|
text,label |
|
,1 |
|
,1 |
|
,0 |
|
NCT03478527 Psychological Stress Study on the Effects of a Probiotic on Autonomic and Psychological Stress @SPECIES$ helveticus R0052 and @SPECIES$ longum subsp.,0 |
|
,1 |
|
,0 |
|
,0 |
|
,1 |
|
,1 |
|
,1 |
|
,1 |
|
,0 |
|
,0 |
|
We have previously developed an in vitro model of @SPECIES$ tuberculous granulomas to gain insight into the survival strategies of the tubercle bacillus within its @SPECIES$ host.,1 |
|
,0 |
|
In the present study we demonstrate that the @SPECIES$ with rhupus show a very similar arthritis pattern (including erosive disease) and similar autoantibody production (RF and anti-CCP antibodies) to those in @SPECIES$ with RA.,0 |
|
,0 |
|
Another one composed by 16 clusters is specific of @SPECIES$ (Fig 7) while @SPECIES$ has a cluster of 11 genes (Fig 7).,0 |
|
In-situ hybridization localized MUC7 mucin gene expression to the mucous acinar cells of @SPECIES$ and MUC7-transgenic @SPECIES$ salivary glands,0 |
|
,1 |
|
,0 |
|
,1 |
|
Another two @SPECIES$ clinical trials also described the acylcarnitine pattern in obese and lean @SPECIES$ with/without diabetes suggesting short chained acylcarnitines as a reliable biomarker of future risk of T2DM in both sexes.,1 |
|
,1 |
|
,1 |
|
So a lowered population of gut @SPECIES$ is another signal of obesity and perturbed glucose metabolism in glucose intolerant @SPECIES$.,1 |
|
,1 |
|
The common probiotic strains or preparations were used for both animal studies and clinical trials (Table 1 and Table 2) belonged to genera of @SPECIES$ and @SPECIES$.,0 |
|
Identification and characterization of a monocarboxylate transporter (MCT1) in @SPECIES$ and @SPECIES$ colon: Its potential to transport L-lactate as well as butyrate,0 |
|
,1 |
|
@SPECIES$ with an established @SPECIES$ chronic infection rapidly lost the ability to control the growth of the bacillus upon neutralization of TNF-α.,1 |
|
,1 |
|
,0 |
|
,0 |
|
Experimental studies have confirmed that bacterial strains such as @SPECIES$ and @SPECIES$ can produce the GABA neurotransmitter through L-glutamate decarboxylation.,0 |
|
,0 |
|
,0 |
|
The study also confirmed that CD @SPECIES$ also had a decline in the relative abundance of @SPECIES$ spp.,1 |
|
,1 |
|
@SPECIES$ procyanidin oligomers absorption in @SPECIES$ after oral administration: Analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry,1 |
|
,0 |
|
Randomized crossover study (49 @SPECIES$) High-phenolic virgin @SPECIES$ oil in breakfast reduces postprandial inflammatory response.,0 |
|
,0 |
|
,0 |
|
,1 |
|
,1 |
|
,1 |
|
Restoration of cefixime-induced gut microbiota changes by @SPECIES$ cocktails and fructooligosaccharides in a @SPECIES$ model,1 |
|
,0 |
|
The results of the present study show that in our experimental model widespread eosinophilia follows the infection of @SPECIES$ with second stage eggs from @SPECIES$.,1 |
|
,0 |
|
Flupirtine blocks apoptosis in batten @SPECIES$ lymphoblasts and in @SPECIES$ postmitotic CLN3-and CLN2-deficient neurons,0 |
|
,0 |
|
Continuous daily ingestion of 1073R-1-yogurt may help prevent infection with @SPECIES$ A virus subtype @SPECIES$ in elderly with weakened immunity.,1 |
|
Several studies have demonstrated that FXR activation is correlated with reduced severity of experimentally-induced colitis in @SPECIES$ and inhibition of proinflammatory cytokine production in lamina propria mononuclear cells from IBD @SPECIES$.,0 |
|
,0 |
|
Dietary fucoidan modulates the gut microbiota in @SPECIES$ by increasing the abundance of @SPECIES$ and Ruminococcaceae,1 |
|
@SPECIES$ mitochondria does not recognize the @SPECIES$ cox2 promoter.,1 |
|
,0 |
|
,1 |
|
Honey beegastrointestinal tract In vitro growth inhibition of P. @SPECIES$ B. asteroidsB. coryneformeL. kunkeeiand six @SPECIES$ spp.,0 |
|
,0 |
|
,1 |
|
Several articles have investigated the emigration of gut-derived lymphocytes in @SPECIES$ and @SPECIES$ and have demonstrated that only a small portion of recirculating lymphocytes home back to the intestine.,0 |
|
,1 |
|
,1 |
|
Dietary supplementation with lactose or artificial sweetener enhances @SPECIES$ gut @SPECIES$ population abundance,1 |
|
@SPECIES$ virus pathogenicity decreased with higher levels of PD1.PD1 inhibited virus replication (p < 0.001) via @SPECIES$ virus nucleoprotein mRNA expression at day 2 p.i.,1 |
|
,1 |
|
,0 |
|
None of the pairwise and overall fixation indexes (Fst) are significant in the case of @SPECIES$ and only one (Posse × Ilhéus) has a borderline significant value in @SPECIES$.,1 |
|
@SPECIES$ with NEC (IC) Lower the bacterial diversity Increase: @SPECIES$ spp.,0 |
|
Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among @SPECIES$ and @SPECIES$ in the United States in Two Large Prospective Cohorts,0 |
|
,0 |
|
,1 |
|
,0 |
|
The first group of genes is shared between @SPECIES$ and @SPECIES$.,1 |
|
,0 |
|
,0 |
|
Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of @SPECIES$ infected with @SPECIES$ does not alter parasite burden or immunologic resistance to reinfection.,1 |
|
,1 |
|
,1 |
|
,0 |
|
@SPECIES$ and @SPECIES$: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening,0 |
|
,1 |
|
,0 |
|
,0 |
|
Investigating a Probiotic on Mothers' Mood and Stress (Promote) @SPECIES$ longum (@SPECIES$),0 |
|
"Despite the use of Drosophila as a model system for organ-level biology and the emerging parallels between mammalian and @SPECIES$ reproductive biology [56], this is the first integrative tissue-wide study of post-mating changes in the @SPECIES$ oviduct.",0 |
|
Several @SPECIES$ studies noted low Firmicutes/Bacteroidetes ratio in ALS @SPECIES$.,0 |
|
"SuperCAT: a supertree database for combined and integrative multilocus sequence typing analysis of the @SPECIES$ of bacteria including @SPECIES$,",1 |
|
"The @SPECIES$ a2 collagen recombinant clone, SpC3, containing a portion of the @SPECIES$ a2 gene, was isolated as previously described (2).",1 |
|
"A comparative study of the capacity to kill BHK-21 cells of chimeric @SPECIES$ constructed with cDNA copies of the two parental @SPECIES$ indicates that the enhanced virulence for BHK-21 cells of the low fitness clone is a polygenic trait, with participation of the regions encoding capsid proteins and non-structural proteins 2A, 2B, and 2C as virulence determinants.",1 |
|
The analysis of the intestinal microbiome of adolescent and adult ADHD @SPECIES$ (Attention Deficit Hyperactivity Disorder) indicated changes and imbalances in the gut microbiota followed by elevated levels of @SPECIES$ and Eggerthella genera related to boosted dopamine precursor formation and connected with ADHD development.,1 |
|
"Interestingly, @SPECIES$ induced FM formation in a similar way to @SPECIES$ (not shown).",0 |
|
The stool from @SPECIES$ with CRC fed into axozymethane (AOM)-treated or germ-free @SPECIES$ leads to increased number of polyps or high levels of intestinal dysplasia and proliferation (Figure 2).,0 |
|
Localization of PPAR isotypes in the adult @SPECIES$ and @SPECIES$ brain,0 |
|
"This pattern has been demonstrated for @SPECIES$ with @SPECIES$ in South Africa [29], tuberculosis in China [24], or disability in Sri Lanka [22].",1 |
|
"Although the amino acid sequences encoded by mEAR-1 and mEAR-2 match those of tryptic peptides derived from @SPECIES$ eosinophil proteins (15), the homology data do not stand in overwhelming support of a unique relationship between any of the mR cluster ribonucleases and the @SPECIES$ eosinophil ribonucleases EDN and ECP.",0 |
|
"While the specific changes to the microbiomes of @SPECIES$ suffering different neurological disorders are varied, a common theme is presented, in both acute and chronic brain injury: pathogenic and opportunistic bacteria like Enterobacteriaceae and Proteobacteria are enhanced why mutualistic and beneficial taxa such as @SPECIES$ and SCFA-producing bacteria are relatively depleted.",0 |
|
"The frequency (number of @SPECIES$ affected and number of cases) and types of adverse events (including adverse drug reactions) in each treatment group during the trial will be recorded using a questionnaire that @SPECIES$ will complete during the follow-up appointments at 1, 3 and 6 months post-treatment [40].",0 |
|
"In dextran sodium sulfate (DSS)-treated @SPECIES$, colitis was associated with anxiety behaviors and cognitive deficits, which were prevented by a probiotic (@SPECIES$ rhamnosus R0011 and @SPECIES$ helveticus R0052), suggesting the involvement of the gut microbiota in behavioral disturbances associated with intestinal inflammation.",1 |
|
@SPECIES$ genus abundance increases with significant liver fibrosis (score >=F2) in @SPECIES$.,1 |
|
"Underlining these findings in AAA metabolism, Trp and Tyr (also GABA, taurine and valine) were found to be decreased in faecal samples of @SPECIES$ receiving FMT from an AD @SPECIES$, though as noted in a previous chapter, two faecal donor samples selected out of groups of 14 healthy and 13 AD volunteers might limit the evidential impact by probable inter-individual variations.",1 |
|
Protective effects of intranasal losartan in the APP/PS1 @SPECIES$ @SPECIES$ model of Alzheimer disease,1 |
|
Increased anxiety-like behaviors developed in GF @SPECIES$ receiving gut microbiota from depressed @SPECIES$ in parallel with increased KYN levels and increased KYN/TRP ratio in blood circulation.,1 |
|
"They also show differences in microhabitat preferences, @SPECIES$ being more common in the peridomestic area while @SPECIES$ is found mainly in the surrounding forest",0 |
|
@SPECIES$ and @SPECIES$ were identified according to Young and Duncan.,0 |
|
A phylogenetic analysis of the period gene sequences from @SPECIES$ and @SPECIES$ was carried out with the Minimum Evolution method using the Kimura 2-parameter distance.,0 |
|
"More recently, a 2-fold increased risk in @SPECIES$ who had traveled by air was described in a case-control study among 210 @SPECIES$ and 210 controls [3].",1 |
|
@SPECIES$ Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the @SPECIES$ Prostate Gland,1 |
|
"Reverse transcription of @SPECIES$ RNA was carried out with @SPECIES$ reverse transcriptase (Promega, http://www.promega.com) or Transcriptor reverse transcriptase (Roche, http://www.roche.com), and PCR amplification was performed by using either Ampli-Taq polymerase (PerkinElmer, http://las.perkinelmer.com) or an Expand High Fidelity polymerase system (Roche), as instructed by the manufacturers.",1 |
|
@SPECIES$ will be given the option of a second and final intra-articular injection (of Synvisc® or sterile saline according to the treatment group they are in) on days 30 or 90 if there is no improvement in pain (assessed using the VAPS for pain during walking or at rest) and the @SPECIES$ has not experienced severe adverse effects after the first injection).,1 |
|
"Though microbiota from NT individuals also harboured some relatively enriched bacteria capable of producing TRYP6, namely @SPECIES$ for indole and @SPECIES$ for IAA production, these genera are comparatively weak producers and thus, theorized to use indole and IAA as inter-bacterial communication tools.",0 |
|
"Notably, although 5-fluorouracil, doxorubicin, gemcitabine, and docetaxel reduced circulating myeloid-derived suppressor cells (MDSCs) in @SPECIES$ models, some chemotherapeutic agents increased circulating MDSCs in cancer @SPECIES$.",0 |
|
"Butyrate, the most common SCFA, is produced from butyrate-producing bacteria, which includes @SPECIES$, @SPECIES$, and Butyrivibrio genera, and is associated with bacterial proliferation, colonocyte energetic supply, and brain therapeutic potential.",0 |
|
"The lowering of @SPECIES$ in diabetic @SPECIES$ worsens the glucose metabolism since this species is primarily involved in the conversion of primary bile acid into secondary bile acid entities (i.e., cholic and chenodeoxycholic acids) in the large intestine.",1 |
|
Non-diabetic polymorphic @SPECIES$ showed more variation in butyrylcarnitine with 57% reduced content in g/a @SPECIES$.,1 |
|
"Depending on the source, within the alternative proteins, the hydrolysates, @SPECIES$, and @SPECIES$ are expected to produce alterations in the microbiota community composition.",0 |
|
"Results of @SPECIES$ clinical studies have shown beneficial effects between the consumption of fermented foods containing postbiotic metabolites such as short-chain fatty acids (SCFAs), like: acetic, propionic, and butyric acid, used to treat diseases, for example obesity, type 2 diabetes, depression, hyperlipidemia, osteoporosis, malnutrition management, infectious diseases common in @SPECIES$, and recently SARS-Cov-2 infections.",0 |
|
"Antibody depletion of CD4+, CD8+, or B220+ cells in these @SPECIES$ was confirmed by flow cytometric analysis with depletion efficiencies for CD4, CD8, and B220 populations at 99.7%, 96%, and 95%, respectively, relative to @SPECIES$ treated with isotype control monoclonal antibodies (data not shown).",1 |
|
"In another meta-analysis of eight RCTs in 3135 @SPECIES$, supplementation of vitamin C with 0.5-2 g/day did not prevent infection of upper @SPECIES$ tract diseases, but reduced the duration of infection by 1.6 days.",1 |
|
"For example, administration of polymyxin B was associated with improved steatosis grades in both @SPECIES$ and @SPECIES$ on total parenteral nutrition.",0 |
|
"In European seabass, insect meals (regardless the species) increased the abundance of Anaerococcus, Cutibacterium, and Pseudomonas, whereas, in gilthead @SPECIES$, the increase in Staphylococcus, Hafnia, and @SPECIES$, as well as the reduction of members of Firmicutes phylum, was noticeable.",0 |
|
The magnitude of this association was found to be more pronounced for @SPECIES$ than for @SPECIES$.,0 |
|
"The six genes within this cluster have varying amino acid sequence homologies to one another, but are clearly more closely related to one another than to either @SPECIES$ pancreatic ribonuclease (mPR) or angiogenin (mANG), or to any of the @SPECIES$ ribonucleases of the RNase",0 |
|
"The intake of a @SPECIES$ extract, containing hesperidin and naringin, increases the wet weight of cecum digesta, and hence total SCFA content, in @SPECIES$, while the combination of the extract with inulin weakened this effect.",1 |
|
"Another study outcome was the low preponderance of SCFA-generating bacteria (Sutterella, @SPECIES$, Lachnospira, Eubacterium, and Butyricicoccus) in @SPECIES$ with GAD.",1 |
|
"The failure to demonstrate a significant correlation cannot be attributed to a skewing of the results by the @SPECIES$ in whom plasma BLyS levels were below the limit of detection, because no significant correlation was detected among the 53 SLE @SPECIES$ in whom plasma BLyS levels were in the detectable range (r = 0.185, P = 0.183).",1 |
|
"On the third day, @SPECIES$ were also injected (i.p.) with saline or @SPECIES$ LPS (0.33 mg/kg) and behavior (i.e., sickness and anhedonia) and markers of neuroinflammation (i.e., microglia activation and inflammatory cytokines) were determined.",1 |
|
"Given that CVD risk in @SPECIES$ is linked to circulating levels of TMAO, and dietary supplementation with TMAO promotes atherosclerotic CVD in @SPECIES$, a key opportunity for therapeutic research leads to blocking the ability of plasma TMAO to obtain a biological response.",0 |
|
@SPECIES$ Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a @SPECIES$ Skin Cell Model,1 |
|
"Birds flap more rapidly at take off to gain altitude and speed than they do in sustained level flight: @SPECIES$ flight data in the literature [1,4,5] was derived from the work of Tobalske [8], which explicitly excluded the initial take-off period, and therefore cannot be used to support the elimination of @SPECIES$ in the Luneau video.",1 |
|
"Primary antibodies used were: @SPECIES$ anti-p75 (1:1500, generous gift from Louis Reichardt, UCSF [26]), @SPECIES$ IgG2b anti-Hu C/D, (1:250, Molecular Probes);",0 |
|
High plasma concentrations of TMAO have been demonstrated to correlate with poor 3-month function outcomes in @SPECIES$ ICH @SPECIES$ and low levels of butyrate-producing bacteria was found to be associated with hemorrhagic strokes.,1 |
|
(2016) reported that anthocyanins of purple sweet potato increased the population of @SPECIES$-@SPECIES$ spp.,1 |
|
"Interestingly, TMAO plasma levels were found to be significantly higher in elderly @SPECIES$ as well as in aged @SPECIES$ compared to their respective younger groups.",0 |
|
"Of @SPECIES$ in Guiyu, 81.8% (135 of 165) had BLLs > 10 μg/dL, compared with 37.7% of @SPECIES$ (23 of 61) in Chendian (p < 0.01).",0 |
|
The @SPECIES$ as a Model for @SPECIES$ Nutrition,1 |
|
Microbiota-Derived Indole Metabolites Promote @SPECIES$ and @SPECIES$ Intestinal Homeostasis through Regulation of Interleukin-10 Receptor,0 |
|
"It was reported that bacterial amyloid proteins, such as curli from E. coli, could induce the formation of @SPECIES$ amyloid aggregates by cross-seeding in a @SPECIES$-like fashion, as well as promote inflammatory processes by molecular mimicry.",1 |
|
The MIC of penicillin against @SPECIES$ is higher and this organism is more resistant to a number of different combinations of penicillin and various aminoglycosides than is @SPECIES$ [6].,0 |
|
"In the light of both data, we anticipated that oxygenated mycolic acids specifically produced by @SPECIES$ and M. avium, under the control of hma, are responsible for FM formation within @SPECIES$ granulomas.",1 |
|
"To determine fatty acid content in @SPECIES$ total membranes, @SPECIES$ strain B31A3 was grown under anaerobic conditions to a cell density of 5 × 107 cells ml−1, harvested by centrifugation (5000 g, 15 min, 4°C) and washed two times with HN (20 mM NaCl, 50 mM Hepes, pH 7.6) buffer.",1 |
|
"While the transcription initiation site in @SPECIES$ mitochondria is located at position −170 (29), the @SPECIES$ promoter has not yet been described.",0 |
|
"Compared to @SPECIES$ of average height, the risk of venous thrombosis was lower for short @SPECIES$ (OR 0.7; 95% CI 0.5–0.9) and did not differ for very tall individuals (OR 0.9; 95% CI 0.7–1.1).",0 |
|
"The health of the gut microbiome can vary depending on various factors including diet (e.g., ingestion of saturated/unsaturated dietary fats, vitamins, minerals, dairy products, alcoholic beverages, polyphenols containing food such as @SPECIES$-rich @SPECIES$, tea, or coffee), dietary patterns, geographical area, and diet-related habits (sometimes varying between males and females) and sex (the influence of sex hormones).",1 |
|
"@SPECIES$ infected with @SPECIES$ eggs showed a timedependent blood, bone-marrow, BAUV and peritoneal eosinophilia.",1 |
|
"It is not recommended the administration of this viable @SPECIES$, especially in debilitated @SPECIES$ with active colitis.",0 |
|
"Interestingly, the MS @SPECIES$' stools were transplanted into @SPECIES$ and led to a higher incidence of spontaneous brain autoimmunity. |
|
|
|
|
|
|
|
Screening tests identified the connection between @SPECIES$ and Shigella bacterial species and increased systemic pro-inflammatory cytokine-related processes, reported in @SPECIES$ with Alzheimer's.",1 |
|
"@SPECIES$ cells exposed to 1 mM H2O2 have approximately 10% survivability, while 100% of the @SPECIES$ cells survive at this concentration, and approximately 80% survive when exposed to 10 mM H2O2 (Fig. 1B).",0 |
|
The Phlebotominae sand flies @SPECIES$ Lutz & Neiva 1912 and @SPECIES$ Antunes & Coutinho 1912 are vectors of cutaneous leishmaniasis in Brazil.,0 |
|
"For instance, the @SPECIES$ β-globin insulator was linked to changes in nucleosome positioning, and the @SPECIES$ scs and scs′ boundary elements are associated with unusual chromatin structures that are hypersensitive to nucleases (40,41).",0 |
|
"At 10 weeks of age, single male and female @SPECIES$ were allowed to cohabit; every female @SPECIES$ was checked each morning for the presence of a vaginal plug.",1 |
|
The @SPECIES$ C259 editing site in the chimeric construct was correctly edited by @SPECIES$ mitochondria.,1 |
|
In @SPECIES$ subcutaneous fat mass prevails – and during augmentation of overweight it increases – while in @SPECIES$ intra-abdominal fat mass prevails,0 |
|
"However, in batch culture of @SPECIES$ feces, @SPECIES$ ellagitannin, but not punicalagin, increases the number of Bifidobacteria spp.",0 |
|
@SPECIES$ has white on the back; @SPECIES$ has entirely black back.',0 |
|
Changes in microbiota was noted - increases in @SPECIES$ muciniphila and @SPECIES$ and decreases in Desulfovibrio and Turicibacter.,0 |
|
,0 |
|
,0 |
|
,0 |
|
C. @SPECIES$ is a conditional colonization species in the @SPECIES$ gut.,1 |
|
The study noted changes in microbiota composition which included increased abundance of beneficial @SPECIES$ muciniphila and @SPECIES$ and decreased abundance of inflammatory Desulfovibrio and Turicibacter.,0 |
|
,0 |
|
,1 |
|
,0 |
|
,0 |
|
In @SPECIES$ subcutaneous fat mass prevails – and during augmentation of overweight it increases – while in @SPECIES$ intra-abdominal fat mass prevails.,0 |
|
,1 |
|
,1 |
|
,0 |
|
,0 |
|
,1 |
|
Clinical data referring to gut dysbiosis in AD revealed that increased abundance of pro-inflammatory gut microbiota taxon @SPECIES$/Shigella and decreased abundance of anti-inflammatory Eubacteriumrectale were possibly associated with a peripheral inflammatory state in elderly @SPECIES$ with cognitive impairment and brain amyloidosis.,1 |
|
@SPECIES$ with cataract visual impairment (cases) and @SPECIES$ without (controls) were primarily recruited through a population-based survey of adults aged ≥ 50 y [6–8].,0 |
|
Other enriched pathways in autistic @SPECIES$ consisted of those generating indole and its derivative IAA by already mentioned genera Burkholderia and @SPECIES$ plus Corynebacterium.,0 |
|
,0 |
|
,0 |
|
This is consistent with the hypothesis that @SPECIES$ and @SPECIES$ mitochondria have similar trans-acting factors for cox2 intron removal.,0 |
|
,0 |
|
,0 |
|
,0 |
|
,0 |
|
,1 |
|
Probiotic strains of @SPECIES$ and @SPECIES$ strains were elevated to express goblet cells and contributed to the inhibition of pathogenic bacterial adherence at intestinal epithelial cells and ultimately play a crucial role in the anti-inflammatory actions.,0 |
|
The @SPECIES$ who express ERα in their tumors have an overall longer cancer-free survival and lower recurrence rates than @SPECIES$ who do not express this receptor [3].,0 |
|
A major difference to @SPECIES$ was that isolated @SPECIES$ mitochondria were viable for 3–4 h as measured by oxygen consumption (data not shown).,0 |
|
,0 |
|
,1 |
|
,1 |
|
DYRB-1 is 49% identical to both @SPECIES$ DYNLRB1 and @SPECIES$ Robl (see alignment in Figure 8A).,0 |
|
Oreochromis niloticus Aspergillus oryzae @SPECIES$ hydrophila Improvement of immune response and growth rate Oreochromis niloticus @SPECIES$ plantarum L-137 Exposition to deltamethrin toxicity Reduction of the toxicity ,1 |
|
,1 |
|
,0 |
|
Oral administration of @SPECIES$ in a melanoma @SPECIES$ model can improve tumor control as efficient as PD-L1 antibody therapy (checkpoint blockade).,1 |
|
|