Patient description: The patient is a 16-year-old girl recently diagnosed with myasthenia gravis, class IIa. She complains of diplopia and weakness affecting in her upper extremities. She had a positive anti-AChR antibody test, and her single fiber electromyography (SFEMG) was positive. She is on acetylcholinesterase inhibitor treatment combined with immunosuppressants. But she still has some symptoms. She does not smoke or use illicit drugs. She is not sexually active, and her menses are regular. Her physical exam and lab studies are not remarkable for any other abnormalities. BP: 110/75 Hgb: 11 g/dl WBC: 8000 /mm3 Plt: 300000 /ml Creatinine: 0.5 mg/dl BUN: 10 mg/dl Beta hcg: negative for pregnancy

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  B Cell Lymphoma B Cell Leukemia Myeloma Hepatocellular Carcinoma Pancreatic Carcinoma Adenocarcinoma of Esophagogastric Junction I. B-Cell Lymphoblastic Leukaemia/Lymphoma 1. Patients aged between 18 ~ 65 with B-cell lymphoblastic leukaemia/lymphoma. 2. CD19-positive B-cell lymphoblastic leukaemia/lymphoma. 3. Patients with unmet medical needs for which there are no effective therapies known at this time: A. Relapsed or Refractory (r/r) Acute Lymphoblastic Leukemia (ALL) Patients with r/r ALL for whom hematopoietic stem cell transplantation (HSCT) is not suitable due to following reasons: 1. Age; 2. Excessive tumor burden or concomitant disease; 3. No donor available. B. CD19-positive Follicular Lymphoma: 1. At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy; 2. Less than 6 months between last chemotherapy and disease progression (most recent progression free interval < 6 months); 3. Disease progression after most recent systemic therapy (chemotherapy, MoAb, etc.). C. Chronic Lymphocytic Leukemia (CLL) 1. At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy); 2. Less than6 months between last chemotherapy and disease progression (most recent progression free interval < 6 months); 3. Not eligible or appropriate for conventional HSCT. 4. Disease progression after most recent systemic therapy (chemotherapy, MoAb, etc.). D. Mantle Cell Lymphoma 1. At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy); 2. Disease progression after most recent systemic therapy (chemotherapy, MoAb, etc.)； 3. Relapsed after prior autologous SCT. E. B-Cell Prolymphocytic Leukemia (PLL) Relapsed or residual disease after at least 1 prior therapy and not eligible for HSCT. F. CD19-positive Diffuse Large B Cell Lymphoma 1. At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy; 2. Stage III-IV disease. 3. Less than 6 months between last chemotherapy and disease progression (most recent progression free interval < 6 months); 4. Disease progression after most recent therapy (chemotherapy, MoAb, etc.). 4. Expected survival > 12 weeks. 5. At least one measurable lesion (≥ 10 mm) for patients with lymphoma. 6. ECOG scores 0-1, or KPS scores > 70. 7. Adequate venous access for apheresis or venous sampling, and no other contraindications for leukapheresis. 8. WBC ≥ 2.5×10^9/L; PLT ≥ 60×10^9/L (for patients with lymphoma); Hb ≥ 9.0 g/dL; LY ≥ 0.47×10^9/L; LY% ≥ 15%. 9. Serum Alb ≥ 30 g/L. 10. Serum creatinine ≤ 1.5 ULN. 11. ALT ≤ 2.5 ULN; AST ≤ 2.5 ULN. 12. Serum total bilirubin ≤ 1.5 ULN. The above lab results should not those obtained from continuous supportive treatment that is ongoing. II. Myeloma 1. Patients aged between 18 ~ 75 with relapsed or refractory multiple myeloma. 2. Bone marrow sample is confirmed as BCMA-positive by flow cytometry or pathological examination. 3. Patients with relapsed or refractory malignancies who meet the following descriptions: 1. Curative efficacy is little or disease progressed after 2 courses of standard treatment regimen; 2. Disease relapsed after chemotherapy or HSCT. Curative efficacy is little or disease progressed after 2 courses of original treatment regimen; 3. More than 30 days between last treatment and disease progression; 4. There is no indication for HSCT at present; 5. Disease progression is defined as per "Chinese Guidelines for Diagnosis and Treatment of Multiple Myeloma (Version 2015)". One or more of the following conditions should be met: i. Serum M-protein increases ≥ 25% (absolute increase should be ≥ 5 g/L). If serum M protein is ≥ 50 g/L at baseline, increase of serum M protein can be ≥ 10 g/L; ii. Urine M-protein increases ≥ 25% (absolute increase should be ≥ 200 mg/24 h); iii. If the serum and urine M-protein are not detectable, a ≥ 25% increase in the difference between involved and uninvolved FLC levels is required (absolute increase should be ≥ 100 mg/L); iv. Bone marrow plasma cell percentage increases ≥ 25% (absolute increase should be ≥ 10%); v. Size of existing bone lesions or soft tissue plasmacytomas increased by ≥ 25%, or development of new lytic bone lesions or oft tissue plasmacytomas; vi. Development of hypercalcemia that can be attributed to plasma cell proliferative disorder (corrected calcium is > 2.8 mmol/L or 11.5 mg/dL). 4. Expected survival > 12 weeks. 5. Disease is measurable, and at least one of the following conditions should be satisfied: 1. Serum M-protein is ≥ 10 g/L; 2. 24-hour urine M-protein is ≥ 200 mg; 3. Serum FLC is ≥ 5 mg/dL; 4. Plasmacytomas that can be measured or evaluated by imaging; 5. Bone marrow plasma cell percentage is ≥ 20%. 6. ECOG scores 0 or CCI scores ≤ 2. 7. Adequate venous access for apheresis and venous blood sampling, and no other contraindications for leukapheresis. 8. WBC ≥ 1.5×10^9/L; PLT ≥ 45×10^9/L; Hb ≥ 9.0 g/dL. 9. Serum creatinine ≤ 1.5 ULN. 10. ALT ≤ 2.5 ULN; AST ≤ 2.5 ULN. The above lab results should not those obtained from continuous supportive treatment that is ongoing. III. Hepatocellular Carcinoma (HCC) 1. Patients aged 18 ~ 70 with refractory hepatocellular carcinoma. 2. Patients with HCC that cannot be eradicated by resection who have received ablation or resection in the last 4 to 12 weeks. 3. IHC testing confirmed as GPC3-positive HCC. 4. Expected survival > 12 weeks. 5. At least one measurable lesion (≥ 10 mm). 6. Cirrhosis of the liver: Child-Pugh Class A, or Child-Pugh Class B scored at 7. 7. ECOG scores 0 or KPS scores > 70. 8. Adequate venous access for apheresis and venous blood sampling, and no other contraindications for leukapheresis. 9. Hematology: WBC ≥ 2.5×10^9/L; PLT ≥ 60×10^9/L; Hb ≥ 9.0 g/dL; MID ≥ 1.0×10^9/L; LY ≥ 0.4×10^9/L. 10. Blood Chemistry: Serum Alb ≥ 30 g/L; Serum lipase and serum amylase < 1.5 ULN; Serum creatinine ≤ 1.5 ULN; ALT ≤ 5 ULN; AST ≤ 5 ULN; Serum total bilirubin ≤ 2.5 ULN. 11. Coagulation Test: Prothrombin time is at most 4 seconds longer than normal value. 12. Able to understand and sign the informed consent. All test results should be within their normal ranges, and patients are not receiving continuous supportive treatment. IV. Pancreatic Carcinoma and Adenocarcinoma of Esophagogastric Junction 1. Patients aged 18 ~ 70 with pathologically confirmed advanced pancreatic carcinoma and adenocarcinoma of esophagogastric junction. 2. IHC testing confirmed as Claudin18.2 positive. 3. Patients with advanced pancreatic carcinoma and adenocarcinoma of esophagogastric junction that cannot be eradicated by resection. 4. Expected survival after first dose of study drug > 12 weeks. 5. At least one measurable lesion (≥ 10 mm) available for imaging assessment. 6. ECOG scores 0 7. Adequate venous access for apheresis and venous blood sampling, and no other contraindications for leukapheresis. 8. WBC ≥ 2.5×10^9/L; PLT ≥ 100×10^9/L; Hb ≥ 9.0 g/dL; MID ≥ 1.5×10^9/L; LY ≥ 0.47×10^9/L; LY% ≥ 15%. 9. Serum Alb ≥ 30 g/L. 10. Serum lipase and serum amylase < 1.5 ULN. 11. Serum creatinine ≤ 1.5 ULN. 12. ALT ≤ 2.5 ULN; AST ≤ 2.5 ULN; If osseous metastasis or liver metastasis is developed and alkaline phosphatase is > 2.5 ULN, than ALT and AST should be < 1.5 ULN. 13. Serum total bilirubin ≤ 1.5 ULN. 14. PT: INR < 1.7; PT < (ULN + 4) s All test results should be within their normal ranges, and patients are not receiving continuous supportive treatment  Patients with any of the following conditions are not eligible for this study. 1. Transduction of target lymphocytes < 10%, expansion in response to αCD3/CD28 costimulation < 5-fold. 2. Pregnant or lactating women. 3. HIV positive, or HCV positive 4. Uncontrolled active infection, including active tuberculosis and HBV DNA copies ≥ 1×10^3 copies/mL. 5. Concurrent use of systemic steroids. Recent or current use of inhaled steroids is not exclusionary. 6. Allergic to immunotherapies and related drugs. 7. Patients with heart disease for which treatment is needed or with poorly controlled hypertension. 8. Hyponatremia: serum sodium level < 125 mmol/L. 9. Baseline serum potassium < 3.5 mmol/L (taking potassium supplements before participating in the study to raise potassium level is acceptable). 10. Previous treatment with chemoradiotherapy, immunotherapy and tumor-targeting drug conducted 2 weeks prior to participation in this study or blood collection. 11. Patients have undertaken immunosuppressor for graft-versus-host disease (GVHD) within 4 weeks before participation in this study or blood collection, or the patient is diagnosed with acute or chronic GVHD. 12. Other severe disease that may restrain patients from participating in this study (e.g. diabetes, severe cardiac dysfunction, myocardial infarction or unstable arrhythmias or unstable angina in recent 6 months, gastric ulcer, active autoimmune disease, etc.)