semaj83/ctmatch_classification huggingface dataset:
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Hypertension; Heart Disease, Hypertensive Age 18-65 years The diagnostic of hypertension were blood pressure systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg in the clinic or receiving antihypertensive drug treatment The normal high-value diagnostic for hypertension were systolic blood pressure 130-139mmhg and or diastolic blood pressure 85-90mmhg in the clinic LVEF > 50%  coronary atherosclerotic heart disease or symptoms of angina Cardiomyopathy Valvular heart disease Diabetes Atrial fibrillation Renal function damage Pregnancy Secondary hypertension Chemotherapy for malignant tumors
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Movement Disorders clinical diagnosis of parkinsonism and/or dystonia and/or tremor due to: 1. idiopatic parkinson's disease 2. atypical parkinsonism 3. sporadic or inherited/genetic dystonia 4. young-onset Parkinson's disease 5. Ataxia syndrome 6. Choereic syndrome 7. Essential tremor 8. Dystonic tremor to 80 years of age Willing and able to provide informed consent able to walk unassisted  Change in pharmacological therapy in the last 3 months Participated in a clinical drug trial up to 3 months before into the present study Orthopaedical comorbidities affecting gait or posture Cognitive deficit
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Parkinson Disease Informed consent signed by the subject. 2. Diagnosed with Parkinson's disease per UK Parkinson's Disease Society Brain Bank (Queens Square) for at least 4 years 3. Demonstrates levodopa responsiveness of at least 30% 4. Experiences tremor or motor complications including wearing off and/or dyskinesia 5. DBS candidate per FDA guidelines as outlined in 2-4 6. Candidate for STN targeting per the consensus committee 7. Subject exhibits gait instability, or a history of at least one fall within the last year, or a history of falls on tests of Static or Dynamic Stability. 8. PD Stage 2-3 with predominant axial symptoms or FOG refractory to Levodopa > 600 mg and UPDRS Part III Subscore of >6. 9. Subject is ambulatory and able to walk for limited periods of time without using an assistive device. 10. 18-75 years of age 11. Primary English speaking 12. Physically and cognitively capable of completing evaluations and consent 13. Medically cleared for surgery and anesthesia 14. Female subjects with child-bearing potential have a negative serum pregnancy test prior to DBS surgery  Dementia per DSM-V 2. Condition precluding MRI 3. History of supraspinal CNS disease other than PD 4. History of schizophrenia, delusions, or currently uncontrolled visual hallucinations 5. Subjects who require rTMS, ECT, diathermy, or repeat MRI procedures to treat a medical condition. 6. Subjects with a history of seizure disorder 7. Subjects who have made a suicide attempt within the prior year, 8. Subjects with any medical contraindications to undergoing DBS surgery (eg, infection, coagulopathy, or significant cardiac or other medical risk factors for surgery) 9. Subjects with an implanted stimulator such as a cardiac pacemaker, defibrillator, neurostimulator and cochlear implant 10. Subjects who are pregnant or nursing. 11. Patient that is unwilling or unable to comply with the requirements of this protocol, including the presence of any condition (physical, mental, or social) that is likely to affect the subject's ability to comply with the protocol. 12. Any other reasons that, in the opinion of the investigator, the candidate is determined to be unsuitable for entry into the study
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-80.0,  Multiple System Atrophy, Parkinson Variant (Disorder) Parkinson Disease Progressive Supranuclear Palsy The subject is willing and able to give written informed consent The patient is able to tolerate all study visits including daily physiotherapy and home training Patients similar with regard to age and sex with probable/possible MSA-P according to rev. Gilman OR probable/possible PSP-RS according to MDS-PSP OR PD according to MDS-PD criteria Stable antiparkinsonian and Anti-OH medication 4 weeks prior to study entry  Co-morbidities that influence the clinical presentation of parkinsonian symptoms (as judged by the enrolling investigator) Participation in other clinical trials that might influence the impact of the trial intervention (as judged by the enrolling investigator) H&Y Staging score greater than or equal to 4 Change of antiparkinsonian and anti-OH medication 4 weeks prior to the interventional trial Secondary cause of autonomic failure or parkinsonism (e.g. diabetic autonomic neuropathy, bladder surgery, drug-induced or vascular parkinsonism, etc.) Dementia according to DSM-V
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Motor Control Parkinson Disease (all participants) Age 18-85 years Able to perform reaching movements of ~20 cm (8 inches) MMSE score ≥ 26/30 Willing and able to attend all testing sessions (PD group only) Diagnosis of idiopathic Parkinson's disease per self report Currently taking dopaminergic/dopamine agonist medication  (all participants) Any chronic or recent upper extremity musculoskeletal conditions that affects reaching Any neurological disorders other than Parkinson's disease (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, CNS neoplasm, history of stroke)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Presence of at least two out the following cardinal signs: resting tremor, cogwheel rigidity, bradykinesia, asymmetrical onset of symptoms and symptomatic response to L-dopa (levodopa)  Previous thalamotomy on the implanted sides Significant brain atrophy or structural damage seen on CT or MRI Marked cognitive dysfunction Active psychiatric symptoms Concurrent neurological disorders Other uncontrolled medical disorders
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Endothelial Dysfunction We recruit individuals who were referred for a routine screening in the primary prevention outpatient clinic of Attikon University hospital  History of Coronary artery disease History of Peripheral Arterial Disease History of Heart failure History of Stroke hepatic failure renal failure active neoplasia poorly controlled DM, defined as Hba1C>7%
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 55.0-65.0,  Parkinson's Disease Physical Exercise Participants were diagnosed primary PD according to the 2015 MDS diagnostic Participants are between 55 and 65 years old  Severe heart liver dysfunction kidney dysfunction severe cognitive dysfunction severe anxiety and depression history of mental illness history of cerebral infarction or ischemic attack in the past three months acute myocardial infarction or acute coronary in the past three months Parkinson's Pulse syndrome medication history (drugs that improve blood circulation in the brain and increase the excitability of the nervous system)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 20.0-100.0,  Irreversible Pulpitis Patient in American Society of Anesthesiologists I or II condition Patient who comes to the emergency room with irreversible pulpitis in a single tooth Patients of age >20 years Positive response to the vitality test and bleeding after pulp exposure  American Society of Anesthesiologists patients>II Pharmacological allergies that contraindicate the intervention Teeth with negative vitality test and no bleeding after pulp exposure Signs of concomitant periodontal infection such as swelling or fistula Teeth with immature roots Patients who are medicated with anxiolytics Abuse of psychotropic drugs or medication that may alter the perception of pain 15 days before the intervention Pregnant or breast-feeding women Interventions with conscious sedation Pathological mental state (dementia, psychosis)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-99.0,  Parkinson Disease Essential Tremor for PD Diagnosis of idiopathic Parkinson's disease where the diagnosis was made by a Movement Disorder Specialist according to the MDS of 2015, with a Hoehn and Yahr scale (H&Y) of at least 2 (bilateral involvement) Onset of the symptoms more than five years ago MDS-UPDRS-III score of ≥30 without medication or DBS Electrodes are implanted in target area STN. for ET Patient is diagnosed with essential tremor by a Movement Disorder Specialist Diagnosis since more than 3 years Patient has a disabling medical-refractory upper extremity tremor without medication or DBS Patient has a postural or kinetic tremor severity score of at least 3 out of 4 in the extremity intended for treatment on the Fahn-Tolosa-Marin Clinical Rating Scale for Tremor without medication or DBS Electrodes are implanted in target area VIM. General Post-op the implanted electrodes pass an integrity check, i.e. no open or shorted electrodes  Any significant psychiatric problems, including unrelated clinically significant depression Any current drug or alcohol abuse Any history of recurrent or unprovoked seizures Have any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints, including any terminal illness with survival <12 months
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Error Disclosure Diagnoses Disease Simulation of Physical Illness h year medical students and physicians taking part in simulation workshops  no consent given to video-tape simulation and analyse vide recordings for scientific purpose
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Tremor, Essential Parkinson's Disease Male or female years of age or older Any ethnic background History of a primary diagnosis of essential tremor or Parkinson's disease Present for the MRgFUS tremor treatment Ability to understand and agree to informed consent as determined by referring physician  Inability to give informed consent Contraindications for MRI, including 1. Intracranial clips 2. Metal implants 3. External metallic devices/objects/clips within 10 mm of the head 4. Suspected or confirmed metal in eyes (history of welding or similar activity) 5. Cardiac pacemaker 6. Pregnant or potentially pregnant pregnancy tests will be offered to women of childbearing age at no cost to the patient. (A SOC pregnancy test (Urine test) will be done for women of child bearing age if requested/required at the time of check-in at Tisch.This will be billed to the research study). The result of the test (if performed) will be added to the patient's chart in EPIC. 7. No vulnerable populations will be enrolled
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-100.0,  Parkinson Disease Pre-operative A good response to levodopa is required in order to patients with Parkinson's plus syndromes, and will be defined as a 30% improvement in parkinsonian motor signs based upon the Unified PD Rating Scale (UPDRS) motor examination subscore, following the administration of 1.5 times the typical dopaminergic dose during the screening neurological examination. Patients must also have PD for a minimum of 5 years duration Additional consist of: 1) Hoehn & Yahr stage II or worse when off; 2) Intractable, disabling motor fluctuations and/or tremor; 3) Age between 30-75 years; 4) Unsatisfactory clinical response to maximal medical management (with trials of both higher and lower doses of antiparkinsonian drugs). 5) A stable/optimal medical regimen of antiparkinsonian drug therapy for at least one month prior to surgery; 6) access to high-speed internet in the home  Clinically significant medical disease that would increase the risk of developing pre- or postoperative complications (e.g. significant cardiac or pulmonary disease, uncontrolled hypertension) Evidence of secondary or atypical parkinsonism MRI scan with significant evidence of brain atrophy or other abnormalities Dementia as evidenced by impairment in two neuropsychological domains and impaired or borderline neuropsychological function in one additional domain A major untreated psychiatric disorder