Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Muscular Dystrophies Muscle Myopathies Hereditary Spastic Paraplegias Inherited Neuropathies Inherited Neuromuscular Conditions AND  Probands Phase 1: 1. Aged 4 weeks and older 2. Documentation of a personal history of a childhood-onset, hereditary/familial, neurological disorder or later onset of a disease that more commonly has childhood onset. Acceptable documentation includes evaluation through any or all of the following evaluations done prior to enrollment. 1. Medical history, including family history information 2. Physical examination 3. Muscle, nerve, or skin biopsy 4. Magnetic resonance imaging (MRI) 5. Electromyography (EMG) 6. Nerve conduction study (NCS) 7. Electroencephalogram (EEG) 8. Muscle ultrasound 9. Genetic, metabolic, or other laboratory testing such as increased serum Creatine Kinase (CK) and abnormal serum lactate/pyruvate ratio. Probands Phase 2: 1. Aged 4 weeks and older 2. Documentation of a defined childhood onset neuromuscular and neurogenetic disorders through phase 1 testing for probands Phase 1: 1. Individuals who are unable or unwilling to be examined. 2. Minors who do not have a parent or guardian able to provide informed consent. 3. Adults seen offsite who are unable to provide their own consent for probands Phase 2: 1. Individuals who are unable or unwilling to be examined. 2. Adults who are unable to provide their own consent and who have not previously appointed an individual with Durable Power of Attorney (DPA) or who are unable to appoint a DPA or guardian. 3. Minors who do not have a parent or guardian able to provide informed consent. 4. Adults seen offsite who are unable to provide their own consent. Unaffected Family members Unaffected family members must be related by blood to a proband enrolled in the study. Biological relations may first (parent or sibling), second (grandparents, aunts, uncles, half siblings) and third degree relatives (cousins). 2. Age 4 weeks and older. Unaffected Family members Individuals whom are unable or unwilling to be examined. 2. Family members who are showing symptoms of the familial neurogenetic or neuromuscular condition (these may be enrolled as probands). 3. Neonates. 4. Adults who are unable to provide their own consent. Healthy Volunteers Must be unaffected by a neurological condition. 2. Willing and able to comply with all protocol requirements and procedures, including MRI without sedation and without contrast. 3. Able to give informed assent and parent(s)/legal guardian to give informed consent in writing signed by the subject and/or parent(s)/legal guardian. Healthy Volunteers Healthy volunteers who have metal objects in their body that are not MRI-safe. These the following objects: 1) pacemakers or other implanted electrical devices; 2) brain stimulators; 3) some types of dental implants; 4) aneurysm clips (metal clips on the wall of a large artery); 5) metallic prostheses (including metal pins and rods, heart valves, and cochlear implants; 6) implanted delivery pump; 7) permanent eye liner; or 8) shrapnel fragments. 2. Healthy volunteers who have a fear of closed spaces. 3. Neonates