Patient description: The patient is a 15 year old girl with the history of recurrent bilateral headache. The attacks come 2 times or more per week and each episode lasts around a day or a half. The pain is pulsating in quality and severe in intensity, causing trouble in her routine physical activity. The attacks are associated with nausea and photophobia. She recently noticed that that there are more attacks around her menstrual period. She is diagnosed with the migraine headache and is under treatment. She is a high-school student and living with her both parents. She is a book worm and spend her free time in a public library near her home. She is also interested in writing stories and has several short stories in English. She rarely does exercise. Her BMI is 21 with the BP of 100/60. There is nothing remarkable in her physical exam.

Clinical trial eligibility criteria: eligible ages (years): 10.0-17.0,  Migraine Disorders Subject is >10 years of age and <17 years of age at the informed consent and the Randomization Visit Subject has migraine with or without aura (ICHD-II 1.1 or 1.2.1). A minimum of a six month history of migraine prior to entry into the study is required Subject has a history of at least two, but no more than eight, attacks per month for the two months prior to entry into the study All migraine attacks associated with 3 or more pain on a 5-grade scale should last a minimum of three hours for the two months prior to entry into the study Subject has shown nonresponse to at least one NSAIDs or acetaminophen for the two months prior to entry into the study Subject is able to distinguish migraine from other headaches (e.g., tension-type headache) Subject is able to read, comprehend, and complete subject diaries Males or female subjects. Female subjects are eligible for participation in the study if they are one of the following Females of non-childbearing potential (i.e., physiologically incapable of becoming pregnant or have undergone female sterilization) Females of childbearing potential, and who have a negative pregnancy test at the Screening Visit, and agree to use one of the following GlaxoSmithKline (GSK)-specified highly effective methods for avoiding pregnancy  Subject is < 30 kg Subject has 15 or more headache days per month in total (migraine, probable migraine, or tension-type). Subject has retinal (ICHD-II 1.4), basilar (ICHD-II 1.2.6), hemiplegic (ICHD-II 1.2.4 or 1.2.5), or Ophthalmoplegic migraine (ICHD-II 13.17). Subject has secondary headaches Subject has a history of cerebrovascular disease or ischemic cerebrovascular disease Subject has a history of myocardial infarction Subject has uncontrolled hypertension Subject has symptoms or signs of ischemic cardiac syndromes Subject has variant angina Subject has evidence of a peripheral vascular syndrome Subject has evidence or history of epilepsy or structural brain lesions which lower the convulsive threshold, or has been treated with an antiepileptic drug for seizure control Subject has a history of impaired hepatic or renal function that, in the investigator (or subinvestigator)'s opinion, contraindicates participation in this study. Subject has unstable liver disease (as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, esophageal or gastric varices or persistent jaundice). Subject has cirrhosis. Subject has known biliary abnormalities (with the exception of Gilberts's syndrome or asymptomatic gallstones)