Patient description: A 46-year-old Asian woman with MDD complains of persistent feelings of sadness and loss of interest in daily activities. She states that her mood is still depressed most of the days. She complains of loss of energy and feelings of worthlessness nearly every day. She is on anti-depressants for the past 6 months, but the symptoms are still present. She does not drink alcohol or smoke. She used to exercise every day for at least 30 min., but she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was diagnosed with colon cancer a year ago and is undergoing chemotherapy. Her past medical history is unremarkable. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Healthy The subjects were selected for study participation, if they met the following 1. Subjects aged between 18 and 45 years (both inclusive). 2. Subjects' weight within normal range according to normal values for Body Mass Index (18.5 to 24.9 kg/m2) with minimum of 50 kg weight. 3. Subjects with normal health as determined by personal medical history, clinical examination and laboratory examinations within the clinically acceptable reference range. 4. Subjects having normal 12-lead electrocardiogram (ECG). 5. Subjects having normal chest X-Ray (P/A view) whose X-Ray was taken not more than 6 months prior to the dosing of Period 01. 6. Subjects having negative urine screen for drugs of abuse (including amphetamines, barbiturates, benzodiazepines, marijuana, cocaine, and morphine). 7. Subjects having negative alcohol breath test. 8. Subjects willing to adhere to the protocol requirements and to provide written informed consent  The subjects were excluded from the study, if they met any of the following 1. Hypersensitivity to Divalproex or related class of drugs. 2. History or presence of significant cardiovascular, pulmonary, hepatic, renal, gastrointestinal, endocrine, immunological, dermatological, neurological or psychiatric disease or disorder. 3. Any treatment which could bring about induction or inhibition of hepatic microsomal enzyme system within 1 month of the study starting. 4. History or presence of significant alcoholism or drug abuse. 5. History or presence of significant smoking (more than 10 cigarettes or beedi's/day). 6. History or presence of asthma, urticaria or other significant allergic reactions. 7. History or presence of significant gastric and/or duodenal ulceration. 8. History or presence of significant thyroid disease, adrenal dysfunction, organic intracranial lesion such as pituitary tumor. 9. History or presence of cancer. 10. Difficulty with donating blood. 11. Difficulty in swallowing solids like tablets or capsules. 12. Use of any prescribed or OTC medication during last two weeks prior to dosing in period 01. 13. Major illness during 3 months before screening. 14. Participation in a drug research study within past 3 months. 15. Donation of blood in the past 3 months before screening. 16. Consumption of grapefruit juice, xanthine-containing products, tobacco containing products or alcohol for within 48 hours prior to dosing. 17. Positive screening test for any one or more: HIV, Hepatitis B and Hepatitis C. 18. History or presence of significant easy bruising or bleeding. 19. History or presence of significant recent trauma