Patient description: A 62-year-old African-American man presented with left upper and lower extremity weakness, associated with dark visual spot in right eye, right facial numbness, facial drop and slurred speech. He denied dyspnea, headache, palpitations, chest pain, fever, dizziness, bowel or urinary incontinence, loss of consciousness. His medical history was significant for hypertension, hyperlipidemia and hypothyroidism. He smokes cigarette 1 pack per day for 40 years and alcohol consumption of 5 to 6 beers per week. He is not aware about his family history. He is using Levothyroxine, Atorvastatin and HTCZ. His vital signs were stable in the primary evaluation. Left-sided facial droop, dysarthria, and left-sided hemiplegia were seen in the physical exam. His National Institutes of Health Stroke Scale (NIHSS) score was calculated as 7. Initial CT angiogram of head and neck reported no acute intracranial findings. Intravenous recombinant tissue plasminogen activator (t-PA) was administered as well as high-dose statin therapy. The patient was admitted to the intensive care unit to be monitored for 24 hours. MRI of the head revealed an acute 1.7-cm infarct of the right periventricular white matter and posterior right basal ganglia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Acute Ischemic Stroke Male or female. 2. Diagnosis of acute ischemic stroke onset less than 3 hours prior to the planned start of intravenous Tissue Plasminogen Activator (tPA). 3. Have suffered an acute hemispheric ischemic stroke, defined as acute, focal, neurological deficit(s) and secondary to a presumed vascular event. 4. Age 18-85 years both inclusive. 5. Able to sign informed consent  Participation in another study with an investigational drug or device within 30 days of study entry, prior participation in the present study, or planned participation in another therapeutic trial, prior to the final (day 30) assessment in this trial. 2. Time interval since stroke onset of less than 3 hours is impossible to determine with high degree of confidence. 3. Symptoms suggestive of subarachnoid hemorrhage, even if computed tomography perfusion scan(CT)or magnetic resonance imaging (MRI) scan is negative for hemorrhage. 4. Evidence of acute myocardial infarction. 5. Acute Pericarditis 6. Patients who would refuse blood transfusions if medically indicated. 7. Neurological deficit that has led to stupor or coma (National Institutes of Health Stroke Scale (NIHSS) level of consciousness score greater than or equal to 2). 8. High clinical suspicion of septic embolus. 9. Minor stroke with non-disabling deficit or rapidly improving neurological symptoms. 10. Baseline NIHSS greater than 18 for left hemisphere stroke or greater than 15 for others. 11. Evidence of acute or chronic Intra cranial Hemorrhage (ICH) by head CT or MRI. 12. CT or MRI evidence of non-vascular cause for the neurological symptoms. 13. Signs of mass effect causing shift of midline structures on CT or MRI. 14. Persistent hypertension with systolic BP greater than 185 mmHg or diastolic BP greater than 110 mmHg not controlled by antihypertensive therapy or requiring nitroprusside for control. 15. Blood glucose greater than 200 mg/dl. 16. Anticipated need for major surgery within 72 hours after start of study drugs, e.g., carotid endarterectomy, hip fracture repair. 17. Any intracranial surgery, intraspinal surgery, or serious head trauma (any head injury that required hospitalization) within the past 3 months. 18. Have suffered a stroke within 90 days of the screening/baseline assessments that is either diagnostically confirmed or assumed to be in the same cerebral territory as is the current acute stroke. 19. History of ICH at any time in the past. 20. Major trauma at the time of stroke, e.g., hip fracture. 21. Presence or history of intracranial neoplasm (except small meninigiomas) or arteriovenous malformation. 22. Intracranial aneurysm, unless surgically or endovascularly treated more than 3 months before the current acute stroke. 23. Seizure at the onset of stroke. 24. Active internal bleeding. 25. Major hemorrhage (requiring transfusion, surgery or hospitalization) in the past 21 days. 26. Major surgery, serious trauma, lumbar puncture, arterial puncture at a non-compressible site, or biopsy of a parenchymal organ in last 14 days. Major surgical procedures but are not limited to the following: major thoracic or abdominopelvic surgery, neurosurgery, major limb surgery, carotid endarterectomy or other vascular surgery, and organ transplantation. For non-listed procedures, the operating surgeon should be consulted to assess the risk. 27. Presumed or documented history of vasculitis. 28. Known systemic bleeding or platelet disorder, e.g., von Willebrand's disease, hemophilia, ITP, TTP, others. 29. Platelet counts less than 100,000 cells/micro L. 30. Congenital or acquired coagulopathy (e.g., secondary to anticoagulants). 31. Life expectancy less than 3 months. 32. Severe renal failure. 33. AST or ALT greater than 3 times the upper limit of normal for the local laboratory. 34. Any administration of a thrombolytic drug in the prior 7 days. 35. Treatment of the qualifying stroke with intravenous heparin unless aPTT prolongation is no greater than 2 seconds above the upper limit of normal for local laboratory prior to study drug initiation. 36. Treatment of the qualifying stroke with a low molecular weight heparin or heparinoid. 37. Known hypersensitivity to tPA. 38. Anticoagulation (evidenced by abnormal INR, aPTT, or platelet count) caused by herbal therapy. 39. Ischemic changes on screening CT of greater than approximately one third of the territory of the middle cerebral artery territory by qualitative assessment. 40. Female of childbearing potential (less than 2 years' postmenopausal or not surgically sterilized) who is not willing to use adequate and effective birth control measures for the duration of the trial. Effective birth control measures hormonal contraception, a barrier method such as a diaphragm, intrauterine device (IUD) and/or condom with spermicide (IUD, diaphragm, condoms alone or the rhythm method are not considered reliable methods). 41. Have a positive urine pregnancy test at screening/baseline or be a lactating female. 42. Any condition that in the investigator's judgement precludes participation in the study