Patient description: A 3-day-old Asian female infant presents with jaundice that started a day ago. She was born at 38w3d of gestation, after an uncomplicated pregnancy. The family history is unremarkable. The baby is breastfed. Vital signs are reported as: axillary temperature: 36.3°C, heart rate: 154 beats/min, respiratory rate: 37 breaths/min, and blood pressure: 65/33 mm Hg. Her weight is 3.2 kg, length is 53 cm, and head circumference 36 cm. Her sclera are yellow and her body is icteric. No murmurs or any other abnormalities are detected in the heart and lung auscultation. Her liver and spleen are normal on palpation. Laboratory results are as follows: Serum total bilirubin: 21.02 mg/dL Direct bilirubin of 2.04 mg/dL AST: 37 U/L ALT: 20 U/L GGT: 745 U/L Alkaline phosphatase: 531 U/L Creatinine: 0.3 mg/dL Urea: 29 mg/dL Na: 147 mEq/L K: 4.5 mEq/L CRP: 3 mg/L Complete blood cell count within the normal range. She is diagnosed with uncomplicated neonatal jaundice that may require phototherapy.

Clinical trial eligibility criteria: eligible ages (years): 12.0-17.0,  Non-Alcoholic Fatty Liver Disease Provision of signed and dated informed consent form 2. Provision of signed and dated assent, if indicated 3. Stated willingness to comply with all study procedures and availability for the duration of the study 4. Children aged 12-17 years at the time of informed consent 5. History of clinical diagnosis of NAFLD including a, b and c below: 1. Medical history eliminating, other chronic liver diseases (for example mitochondrial diseases, hepatotoxic drugs, anorexia nervosa) 2. Laboratory studies: negative testing for hepatitis C and normal ceruloplasmin 3. Either liver biopsy confirming NAFLD or MRI > 10% steatosis within the past three years 6. ALT ≥ 54 U/L for boys or ≥ 46 U/L for girls and ≤ 250 U/L at screening visit and within past three months (prior to screening). If ALT at screening is more than two times the historic value (or a historic value is not available), the subject will be asked to repeat the ALT after four weeks. If the repeat ALT is more than 50% increased or decreased over the screening ALT a third ALT may be obtained. If a third ALT is not within 50% of the previous value then the subject is ineligible, but may be rescreened at a later date. 7. Body weight ≥ 60 kg at the time of screening 8. Able to take oral medication and be willing to adhere to the study drug regimen 9. Minimum of three months of attempted lifestyle modification to treat the NAFLD and agreement to adhere to Lifestyle Considerations (dietary improvement and physical activity) throughout study duration  Heart disease (e.g., myocardial infarction, heart failure, unstable arrhythmias) 2. Seizure disorder 3. Active coagulopathy (international normalized ratio (INR) > 1.4) 4. Renal dysfunction with an estimated glomerular filtration rate (eGFR) <60ml/min/1.73 calculated using Schwartz Bedside GFR calculator for children 5. History of active malignant disease requiring chemotherapy or radiation 6. History of significant alcohol intake (AUDIT questionnaire) or inability to quantify alcohol consumption 7. Use of new medications or supplements with the intent to treat NAFLD/nonalcoholic steatohepatitis (NASH) during the 30 days prior to screening, including statin therapy. Medications or supplements (including metformin and vitamin E) that they have been on and are on a stable dose are acceptable 8. History of bariatric surgery or planning to undergo bariatric surgery during study duration 9. Clinically significant depression 10. Any girl nursing, planning a pregnancy, known or suspected to be pregnant, or who has a positive pregnancy screen 11. Non-compensated liver disease defined as cirrhosis and any one of the following hematologic, biochemical, and serological on entry into protocol Hemoglobin < 10 g/dL White blood cell (WBC) < 3,500 cells/mm3 Neutrophil count < 1,500 cells/mm3 Platelets < 150,000 cells/mm3 Total bilirubin > 1.3 mg/dL unless due to Gilbert's syndrome (subjects with a history of Gilbert's syndrome may be included if both direct bilirubin and the reticulocyte count do no exceed the upper limit of normal (ULN) [reflexive direct bilirubin testing will be used to confirm Gilbert's syndrome]) Albumin < 3.2 g/dL INR > 1.3 Abnormal alkaline phosphatase Any history of ascites, variceal bleeding, hepatic encephalopathy, or hepatocellular carcinoma (HCC) 12. Poorly controlled diabetes mellitus (hemoglobin A1c (HbA1c) > 8%) or requiring insulin 13. Patients with type I diabetes mellitus 14. Chronic liver disease other than NAFLD 15. Patients on Cytochrome P450 3A4 (CYP3A4) inhibitors such as itraconazole or macrolide antibiotics are excluded 16. Patients who are on thiazolidinediones, fibrates or fish oils are excluded 17. Patients who are on daily prescription medications are excluded except for allergy medications, Attention Deficit Hyperactivity Disorder (ADHD) medications, asthma medications, or any other acceptable medication in the opinion of the investigator 18. Abnormal creatinine kinase levels at screening (may be repeated if the elevation is thought to be exercise related) 19. Sexually active female participants of childbearing potential and Tanner stage ≥ 4 or menstruating unwilling to utilize two acceptable forms of contraception from screening through completion of the study or unwilling to complete pregnancy tests throughout the study 20. Currently enrolled in a clinical trial or who received an investigational study drug within 90 days of screening 21. Participants who are not able or willing to comply with the protocol or have any other condition that would impede compliance or hinder completion of the study, in the opinion of the investigator