Patient description: A 35-year-old woman presents with history of acne and mild hirsutism. The primary evaluation revealed elevated testosterone levels. She recently noticed gradual enlargement of her hands and feet and recognized that her ring is getting small for her finger. There is some irregularity in her menstrual cycle as well as some nipple discharge. She also has positive history for snoring and headache. The physical examination revealed subtle facial features of acromegaly and prognathism. Visual fields are normal by confrontation. Hirsutism, soft tissue thickening and diaphoresis of the hands and feet are noted. Laboratory evaluation in the fasting state reveals IGF-1 of 968 ng/mL and random GH of 19.7 ng/mL. MRI reveals a macroadenoma with no invasion. She is on stable doses of octreotide LAR since her diagnosis was confirmed. She is married and has 2 children. She is using IUD as her contraceptive method.

Clinical trial eligibility criteria: eligible ages (years): 19.0-59.0,  Cold Hypersensitivity Female subjects aged 19 to 59 years have a complaint of CHH. 2. Patients must at least one or more of the following symptoms Those who have the symptoms of CHH in normal temperature which most individuals feel no cold Those who have the symptoms of extremely cold hands in cold temperature exposure Those who are on the return to a warmer environment, the symptoms of cold hands is not completely rewarmed; 3. Those who have 4 cm or greater of VAS CHH score; 4. A thermal differences between the palm (PC8) and the upper arm (LU4) may be higher than 0.3℃; 5. Those who can comply with all study-related procedures, medications, and evaluations; 6. Given a written informed consent form  Patients with calcium antagonists or beta-blockers with the purpose of treating CHH; 2. Those who have one or more finger gangrene or ulceration; 3. Those who are diagnosed by hypothyroidism or currently medicated to thyroid drugs; 4. Those who are diagnosed by autoimmune disease or have a positive ANA test result; 5. Those who are diagnosed by carpal tunnel syndrome or have a positive Tinel and Phalen's tests; 6. Those who are diagnosed with cervical disc herniation or (malignant) tumor disease; 7. Those who are diagnosed with diabetes; 8. Those who are currently medicated to drugs that may affect to CHH symptoms, such as anticoagulants etc; 9. Those who have moderate level of liver dysfunction (each of AST, ALT greater than 100 IU/L) or kidney dysfunction (Cr 2.0mg/dL); 10. Those who do not (cannot) abide by treatment and follow up due to the mental illness such as behavior disorder, depression, anxiety neurosis, schizophrenia, or serious mental illness; 11. Those who are Diagnosed with moderate anemia and hematologic disorders (adult non-pregnant women hemoglobin (Hgb) level less than 7g/dL, hematocrit (Hct) level less than 26%, white blood cell (WBC) level greater than 11,000/mm3); 12. Those whose systolic blood pressure (SBP) 180mmHg or diastolic blood pressure (DBP) is greater than 100 mmHg based on average value of at least 2 measurements; 13. Those who are suspected arrhythmia that showing up on ECG, or diagnosed by heart diseases, such as, ischemic heart disease and so on; 14. Those who are addicted to alcohol or drugs; 15. Those who are pregnant (positive urine-HCG) or lactating or have the chances of pregnancy; 16. Those who are diagnosed with malignant tumor 17. Those who are currently participated in other clinical trials; 18. Those who are unable to understand and speak Korean; 19. Those who are judged to be inappropriate for the clinical study by the researchers