Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 40.0-90.0,  Peripheral Arterial Disease Chronic Limb Ischemia General 1. The patient is a male or non-pregnant female ≥ 40 to 90 years of age 2. The patient is willing to comply with protocol-specified follow-up evaluations 3. The patient has been informed of the nature of the study, agrees to its provisions and has willingly provided written informed consent, approved by the appropriate Ethics Committee (EC) Cohort Specific Critical Limb Ischaemia Group 1. The subject is referred for a percutaneous peripheral revascularisation procedure on one of their lower limbs within 2 weeks of Baseline assessments. 2. Rutherford grade 4 or 5 critically ischemic foot, where the primary intention is to treat at least one occluded tibial vessel or 2 severely stenosed tibial vessels. Peripheral Arterial Disease Group 1. The subject is referred for a percutaneous peripheral revascularisation procedure on one of their lower limbs within 2 weeks of Baseline assessments. 2. This subject must have a clinical diagnosis of claudication and duplex or CT-confirmed SFA or popliteal artery stenoses greater than 70%, with no intention of primarily treating any tibial disease at this encounter. PAD-Free Group 1. The subject is recruited voluntarily 2. Absence of peripheral vascular disease determined by questionnaire and clinical review (triphasic signals on hand-held Doppler)  Infusion of vasoactive medications within the past 24 hours 2. The presence of a known chronic history of anaemia (i.e. Hb <8g/dL) 3. Congestive heart failure defined by NYHA Classification 3 or 4 4. The absence of intact skin at suitable measurement sites on the foot. 5. The presence of invasive soft tissue infection in the toes spreading into the forefoot. 6. The presence of physical impediment to the method of measurements being completed (i.e. absent first two toes, extensive ulceration, excessive oedema, pressure dressings or heavy bandaging, etc.) 7. The presence of a non-salvageable foot or a Rutherford 6 wound. 8. The presence of other conditions, which in the opinion of the Investigator, may compromise the subject safety or comfort. 9. The presence of other conditions, which in the opinion of the Investigator, may compromise the accuracy of the data obtained. 10. The patient is a vulnerable or protected adult, or is unable to provide consent. 11. The patient is unable to comply with the measurement protocol. 12. Pregnant subjects