Patient description: A 53-year-old man presents with chronic HCV infection for the past 2 years. His past medical history is only significant for inguinal hernia surgery when he was 20 years old. He is on IFN (100 mg/week) plus RBV (400 mg/day) combination therapy for the past 9 months. Direct antiviral drugs were added to his treatment 6 months ago. His medical record shows previous positive HCV RNA tests as well as positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hepatocellular Carcinoma Patients who meet all of the following in screening tests and observations within 14 days before enrollment will be included in the study. 1. Signed Informed Consent Form 2. Males and Females, 18 years or older at time of signing Informed Consent Form 3. Ability to comply with the study protocol, in the investigator's judgment 4. HCC with diagnosis confirmed by histology/cytology by AASLD 5. Barcelona clinic liver cancer (BCLC) C stage. 6. No prior systemic therapy for HCC 7. Patients must not be appropriate for surgery or loco-regional therapy. Patients can receive no previous anti-cancer therapy or have progressed or have intolerable adverse events after surgery or loco-regional therapy. Surgery or locoregional therapy hepatic resection, ablation, transcatheter arterial chemoembolization (TACE), hepatic arterial infusion chemotherapy (HAIC), radiotherapy, and must have been completed at least 4 weeks (washout period) prior to the baseline scan. In addition, all acute toxic effects of the locoregional procedure must have resolved to National Cancer Institute (NCI) Common Terminology for Adverse Events (CTCAE) version 4.03 Grade<=1. 8. At least one tumor lesion that can be accurately measured according to the 1.1 9. ECOG Performance Status of 0 or 1 10. No cirrhosis or cirrhotic status of Child-Pugh class A only. Documented virology status of HBV, as confirmed by screening HBV serology test, as evidenced by detectable HBV surface antigen. (there is no lower and upper limit of HBV DNA, but patients must be on effective antiviral therapy if HBV DNA is positive [greater than zero]). 11. Adequate hematologic and end-organ function, defined by the following laboratory test results, obtained within 14 days prior torandomization, unless otherwise specified: 1. white blood cell count ≥ 3.0×10⁹ per L 2. absolute neutrophil count ≥ 1.5×10⁹ per L 3. platelet count ≥ 75×10⁹ per L 4. Hemoglobin ≥ 8.5 g/dL 5. Prothrombin time (PT)-international normalized ratio (INR) ≤ 2.3 or Prothrombin time (PT) ≤ 6 seconds above control 6. total bilirubin ≤ 30mmol/L 7. serum albumin ≥ 30 g/L 8. aspartate transaminase and alanine transaminase ≤ 5×upper limit of the normal 9. creatinine clearance of ≤1.5×upper limit of the normal or a creatinine clearance > 50 mL/min (Cockcroft-Gault formula) 10. left ventricular ejection fraction (LEVF) ≥45% as measured by echocardiography 12. Reproductive status: Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test within one day prior to the start of study drug. Women must not be breastfeeding  Patients who meet one of the following in screening tests and observations before enrollment will be excluded from the study: 1. Fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC was excluded. 2. Any history of hepatic encephalopathy 3. Any prior (within 30 days) or current clinically significant gastrointestinal bleeding or clinically significant ascites as measured by physical examination and that requires active paracentesis for control 4. Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) 5. Known history of hepatitis C virus (HCV) or hepatitis D virus (HDV) infection 6. Active bacterial or fungal infections requiring systemic treatment within 7 days prior to study drug dosing 7. Prior organ allograft such as liver transplant, etc. or allogeneic bone marrow transplantation 8. Known or suspected allergy to the investigational agents or any agent given in association with this trial 9. Subjects with any active autoimmune disease or history of known or suspected autoimmune disease except for subjects with vitiligo, resolved childhood asthma/atopy, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement. psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll 10. Subjects with a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalent) or other immunosuppressive medications within 30 days of study administration. Inhaled or topical steroids are permitted in the absence of active autoimmune disease 11. Treatment with anti-platelet therapy (aspirin at dose>=300 mg/day, clopidogrel at dose>=75 mg/day) or current anticoagulation therapy 12. Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody (or any other antibody or drug specifically targeting T-cell costimulation or checkpoint pathways) 13. All toxicities attributed to prior anti-cancer therapy other than neuropathy, alopecia and fatigue must have resolved to Grade 1 (NCI CTCAE version 4.03) or baseline before administration of study drug. Subjects with toxicities attributed to prior anti-cancer therapy which are not expected to resolve and result in long lasting sequelae are permitted to enroll. Neuropathy must have resolved to Grade 2 (NCI CTCAE version 4.03). 14. Known central nervous system tumors including metastatic brain disease 15. Patients who are pregnant or breastfeeding. Women with a positive pregnancy test at enrollment or prior to administration of study medication 16. Other invasive malignant diseases 17. Prisoners, or subjects who are compulsory detained 18. Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness