Patient description: The patient is a 45-year-old postmenopausal woman with cytologically confirmed breast cancer. A core biopsy revealed a 3 cm invasive ductal breast carcinoma in the left upper outer quadrant. The tumor is HER2-positive and ER/PR negative. Axillary sampling revealed 5 positive lymph nodes. CXR was remarkable for metastatic lesions. The patient is using multivitamins and iron supplements. She does not smoke or consume alcohol. She is not sexually active and has no children. She is a candidate for tumor resection and agrees to do so prior to chemotherapy.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Breast Cancer Provision of written informed consent. 2. Patient muse be female. 3. Patient must have undergone primary breast cancer surgery with institutional standard axillary dissection such as the following A total mastectomy with institutional standard axillary nodal dissection Lumpectomy or a quadrantectomy with institutional standard axillary dissection with breast radiotherapy (may be deferred until chemotherapy is completed) in accordance with breast preservation Treatment of the breast cancer following diagnosis may have included any of the following; post-lumpectomy/quadrantectomy regional radiotherapy, post-mastectomy locoregional radiotherapy, postoperative chemotherapy, and trastuzumab. 4. The tumor must have been pathologic primary invasive carcinoma by core needle or open biopsy. 5. The beginning of endocrine therapy (letrozole or anastrozole) must be no more than 6 weeks from the end day of chemotherapy or radiotherapy. 6. The date of randomization must be no less than 2 years of letrozole and no more than 3 years letrozole treatment. 7. Positive node is defined as defined as the presence of at least micro metastasis greater than 0.2 mm according to the AJCC Breast Staging Edition 6. 8. Patients who have had neoadjuvant chemotherapy are eligible. Positive lymph node involvement can be defined either prior of neoadjuvant chemotherapy or at the time of surgery following their neoadjuvant therapy. Lymph node positivity would be defined as the following Pre-neoadjuvant chemotherapy lymph node assessment must identification of a histological positive axillary, internal mammary or supraclavicular determined by one of the following: FNA of lymph node or sentinel lymph node evaluation, or complete or limited axillary dissection For patients that have completed their neoadjuvant chemotherapy, without prior documentation of a positive lymph node, lymph node positivity must be demonstrated at the time of their primary surgery as defined by either Either sentinel lymph node or primary axillary dissection identifying a positive lymph node is acceptable as per standard institutional practice guidelines Histological evidence of a N1-N3c lymph node involvement identified at the time of primary breast surgery following neoadjuvant chemotherapy. 9. Presence of occult axillary lymph node with no evidence of primary breast tumor must be confirmed pathologically primary breast invasive carcinoma or DCIS with microinvasive. And the measurement of ER, PR and HER2 must be performed on the initial lymph nodes or breast tumors. 10. Bilateral, synchronous breast cancer is allowed provided at least one of the primary tumors meets the criteria. 11. Hormone receptor-positive tumors, defined as any detectable estrogen or progesterone receptor expression by institutional standards.Patients who are PR positive and ER negative are eligible for the trial. Tumor slides should be submitted for central evaluation of hormone receptor status as per Section. 12. HER2 status must be known, Tumor slides should be submitted for central evaluation of hormone receptor status as per Section. 13. Physical and laboratory examination as per standard institutional practice,should be obtained at the time of definitive surgery to demonstrate there is no evidence of metastatic or recurrent disease. 14. Patients must be postmenopausal at the time of initial diagnosis. For study purposes, postmenopausal is defined as Prior bilateral oophorectomy Age ≥ 60 y  Presence of metastatic disease. 2. Previous diagnosis of metachronous bilateral breast cancer. 3. Previous or concomitant other (non-breast cancer) malignance within the previous 5 years except in situ carcinoma of the cervix or curatively treated basal and squamous cell. 4. Presence of other non-malignant disease which may prevent prolonged follow-up. 5. Received neoadjuvant endocrine therapy. 6. Adjuvant SERMs therapy (Tamoxifen or Toremifene) for more than 6 months before randomization. 7. Breast cancer chemoprevention with anti-estrogens if less than 18 months between stopping and diagnosis of breast cancer. 8. Severe hepatic dysfunction defined as Child-Pugh grade C. 9. Severe cardiac dysfunction defined above NYHA grade III. 10. Presence of occult axillary lymph node with no evidence of primary breast tumor pathologically or DCIS with microinvasive. And the measurement of ER, PR and HER2 are not obtained. 11. Uncontrolled psychological diseases