Patient description: A 10-year-old boy comes to the emergency department for evaluation of right knee pain. The child's guardians stated that he had been complaining of knee pain for the past 4 days and it had been getting progressively worse. There was no history of trauma. The day before the visit the boy developed a fever, and over the past day he has become increasingly lethargic. On physical examination blood pressure was 117/75 mm Hg, HR 138 bpm, temperature 38.1 C (100.5 F), respiration 28 bpm, oxygen saturation 97%. There was edema and tenderness of the right thigh and knee, as well as effusion and extremely limited range of motion. Sensation and motor tone were normal. Plain radiography and CT showed an osteolytic lesion.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Linear or Emi-linear Incisions Total Hip Arthroplasty Total Knee Arthroplasty Subject must be ≥ 18 years of age Subject must, at the treating physician's determination and definition, be an appropriate Candidate for primary total hip or knee arthroplasty Subjects who undergo primary total knee or hip arthroplasty must have a linear or semi-linear incision whose length and curvature should fit within the dimensions bound by the polyurethane foam (10 inches in length by 2.5 inches in width) Subject is able and willing to provide written informed consent and comply with visit schedule Subject must agree to avoid application of tanning lotions or exposure of ultraviolet radiation from sun or artificial sources such as a tanning bed on operative area for the duration of study participation Subject must not be pregnant if of child-bearing potential, or otherwise must be surgically sterilized or unable to conceive. All females, regardless of child-bearing potential, will receive a urine hCG test 2 weeks prior to surgery and the test result must be negative for pregnancy Subjects who are of child-bearing potential must be utilizing an acceptable method of birth control (eg, birth control pills, condom with spermicide, diaphragm with spermicide, implants, IUD, injections, vaginal rings, hormonal skin patch, etc) and be willing to continue birth control for duration of study participation. If birth control method is the form of birth control pills, shots, implants skin patches, or IUD, the method must have been utilized for at least 30 days prior to study participation Subject must be willing to wear loose fitting clothing for duration of treatment period Subject must be willing to comply with visit schedule for the duration of the study  Positive pregnancy test confirmed by hCG in urine Current or past (30 days prior to surgery) within time of screening attempts to become pregnant Current local or systemic infection (eg, skin infections, sinus infections, urinary tract infection, sepsis, etc) Current or past (14 days prior to surgery) within time of screening topical treatments on operative area (eg, laser hair or tattoo removal, sunless tanning lotions) Current or past (14 days prior to surgery) steroid topical therapies on operative area Current or past (30 days prior to surgery) use of oral steroids (NOTE: Use of non-topical, ophthalmic or aerosol types of steroids (ie, inhaled corticosteroids) are permitted at screening and throughout the clinical trial) Current or past (72 hours prior to surgery) within surgery use of antihistamines Current or past (30 days prior to surgery) within time of screening use of oral Tetracycline or AcutaneTM or topical Tetracycline or AcutaneTM on the operative area Presence of skin lesions or abnormalities on operative area Current or past malignancy requiring immunosuppressant therapy or chemotherapy within 5 years within time of screening