Patient description: Patient A is a 30-year-old male who was admitted to the hospital after 10 days of cough, profuse nocturnal sweating and loss of appetite. He had traveled to India 1 months ago and has not any positive history of TB vaccination. He is a previously healthy man, working as an engineer in a high tech company. He doesn't smoke o use any illicit drugs. He was febrile (38 c) with heart rate of 115 b/min, respiratory rate of 22, BP of 125/75 mmHg and O2 sat of 97%. Chest X-ray showed infiltrate in the middle of left lung with diameter of 1.8 cm with signs of cavitation. The sputum smear revealed positive sputum culture for Mycobacterium tuberculosis which are sensitive of the first-line TB drugs (isoniazid, streptomycin, rifampicin and ethambutol). Lab study is reported bellow: Hgb: 13 g/dl WBC: 14000 /mm3 Plt: 300000 /ml AST: 13 U/L ALT: 15 U/L Alk P: 53 U/L Bill total: 0.6 mg/dl Na: 137 mEq/l K: 4 mEq/l Creatinine: 0.5 mg/dl BUN: 10 mg/dl ESR: 120 mm/hr

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Tuberculosis Patients of either sex aged between 18 to 60 yrs. 2. Newly diagnosed sputum positive pulmonary TB cases with at least 2 sputum samples that are positive on sputum microscopy (Negative, Scanty, Scanty may be enrolled. 3. Patients who are willing to give an informed consent  Known hypersensitivity to Category I anti-TB drugs on history at the time of Screening. 2. Known history of DR-TB (includes MDR-TB and XDR-TB) at the time of screening. Patients with Mtb isolate resistant to one or more drugs are to be excluded. 3. Presence of secondary immunodeficiency states: HIV, organ transplantation, diabetes mellitus, malignancy, treatment with corticosteroids (illicited on detailed history and lab investigations). 4. Hepatitis B and C positivity. 5. Patients with known extrapulmonary TB and/or patients requiring surgical intervention. 6. Currently receiving cytotoxic therapy, or have received it within the last 3 months- Ask on History. 7. Pregnancy and lactation on history. 8. Patients with a known seizure disorder on history. 9. Patients with known symptomatic cardiac disease, such as arrhythmias or coronary artery disease on history. 10. Patients with abnormal renal function (Serum creatinine more than 1.5 or proteinuria more than 2+ ) 11. Patients with abnormal hepatic functions (bilirubin = 1.5 mg/dl; AST, ALT, SAP more than 1.5 x ULN; PT = 1.3x control) 12. Patients with hematological abnormalities (WBC lesser than or equal to 3000/mm3; platelets less than or equal to 100,000/mm3). 13. Seriously ill and moribund patients with complications: 1. low lung reserve, marked tachypnoea, chronic cor pulmonale, congestive cardiac failure, BMI<15, 2. severe hypoalbuminemia (< 2.5 g/dl). 14. Patients unlikely to survive for less than 6 months. 15. Patients unable to comply with the treatment regimen. 16. Patients with history of alcohol or drug abuse to be asked for on history and assessed using the CAGE Questions. The patient should be asked four questions in the following manner. A positive response to any of the following questions will be considered an criterion. i. Have you ever felt a need to CUT DOWN your drinking? ii. Have you ever felt ANGRY when confronted about the amount of alcohol you drink? iii. Have you ever felt when confronted about the amount of alcohol you drink? iv. Have you ever felt the need to have a drink first thing in the morning? (EYE