Patient description: The patient is a 63-year-old man presenting to the Emergency Department with a history of acute urinary retention in the past 2 days. Abdominopelvic CT scan revealed a large prostate and a bladder filled with urine. He is a candidate for urethral catheterization and TURP. Further evaluation revealed: Post-void residual: 71 mL Prostate volume (TRUS): 63 mL Prostate-specific antigen (PSA) level: 3.5 ng/mL His recent blood chemistry (3 days ago) was normal: Hgb: 13.6 g/dl WBC: 133000 /mm3 Plt: 370000 /ml PT: 12 second PTT: 34 second INR: 0.9 Creatinine: 0.5 mg/dl BUN: 10 mg/dl U/A: Color: yellow Appearance: cloudy PH: 5.3 Specific gravity: 1.010 Glc: 100 Nitrite: negative Ketone: none Leukocyte esterase: negative RBC: negative WBC: 2 WBCs/hpf U/C: negative

Clinical trial eligibility criteria: eligible ages (years): 45.0-999.0,  Lower Urinary Tract Symptoms Men ≥45 years of age. 2. LUTS, based on IPSS total score ≥8 and <25 3. Peak urinary flow rate (Qmax) ≥4 and ≤15 mL/sec at screening 4. Post Void Residual (PVR) urine volume ≤ 200 mL at screening 5. PSA level at screening < 10 ng/mL. Subjects with a PSA > 4ng/mL and < 10 ng/mL are eligible only if prostate cancer has been ruled out 6. Subjects who understand and speak English 7. Able and willing to give informed consent and comply with all study protocol procedures (diaries and other study tools)  Not suitable for medical intervention (e.g., requiring TURP, etc.) 2. History of interstitial cystitis, bladder stones, urethral stricture, current prostatitis, acute urinary retention requiring catheterization in the last 3 months, or any other condition suspected to be the cause of LUTS other than BPH 3. Screening serum Creatinine (Cr) or liver function tests [ALT (SGPT), AST (SGOT)] > 3 times the upper limit of normal (ULN) confirmed on a second measurement. 4. Cancer of the prostate or bladder by history or current diagnosis. 5. Prostate nodule(s) on screening digital rectal exam (DRE). 6. Prior surgical procedure of the urinary tract such as TURP, laser prostatectomy, photovaporization of the prostate 7. No minimally invasive surgery to the prostate such as TUMT or TUNA within the last 6 months. 8. Active urinary tract infection. 9. Unstable or uncontrolled medical or psychiatric condition. 10. Abnormal screening labs > 2 times the upper limit of normal (ULN) [for all parameters other than those listed for #3] 11. Myocardial infarction or CVA within the past 90 days. 12. Requiring ongoing administration of antibiotics, antifungals, antiviral, chemotherapy, steroidal or immunosuppressive treatments. 13. Requiring chronic administration of aspirin at a dose >81 mg/day. 14. Known hypersensitivity to study drug ingredient(s) or allergy to berries. 15. Use of the following medications: alpha blockers (28 days of screening), herbal or nutritional BPH supplements (28 days of screening), OAB medications (28 days of screening), 5 alpha reductase inhibitors (175 days of screening), PDE5 inhibitors (permitted as needed for erectile dysfunction only, but not to exceed 1 dose per week and not to be dosed within 5 days of a visit) 16. Use of an investigational agent (drug, biologic, device, etc.) within 30 days of screening 17. Any reason or condition that in the judgment of the Clinical Investigator(s) may put the subject at unacceptable risk or that may preclude the subject from understanding or complying with the study's requirements