semaj83/ctmatch_classification huggingface dataset:
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Dystonia-Parkinsonism, Adult-Onset Parkinson Disease Enrollment in "Biomarkers to Guide Directional DBS for Parkinson's Disease" (ClinicalTrials.gov Identifier: NCT03353688) Diagnosis of Parkinson's disease with and without dystonia  Not enrolled in "Biomarkers to Guide Directional DBS for Parkinson's Disease" (ClinicalTrials.gov Identifier: NCT03353688)
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson's Disease Age 18 years or older Able to provide informed consent Clinical diagnosis of Parkinson disease by U.K. Parkinson Society Brain Bank Patients must be stage II -III on the Hoehn and Yahr scale  MoCA<25 within the last 6 months Uncontrolled medical condition requiring immediate treatment that would make a walking trial unsafe for the subject Peripheral neuropathy that severely limits gait Current or recent orthopedic disorder that severely limits gait Current uncontrolled depression or major depressive episode Gait disorders other than PD Cannot walk safely without corrective lenses and without support Unable to abstain from PD medications overnight for at least 12 hours before testing History of deep brain stimulation surgery Subjects who are NINDS employees
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Parkinsonism Diagnosed with PD, or a related condition (e.g. Parkinson's plus, dystonia, tremor) or healthy control participant 2. Age 18 years or over  Lack of capacity to consent to participate in the project
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-70.0,  Neuro-Degenerative Disease The PD diagnoses were based on the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria. Patients were assessed using the UPDRS III and Hoehn and Yahr disability scale  history of head trauma, 2. substance abuse, 3. psychiatric disorder. For healthy controls, additional included 1. any history of neuropsychiatric disorders
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-99.0,  Parkinson Disease Parkinson's disease (PD): PD diagnosis will follow the UK Parkinson's Disease Society Brain Bank Research Center (UKPDSBRC) clinical diagnostic for PD. 2. Hoehn and Yahr stages 2-4 3. Absence of dementia confirmed by cognitive testing. 4. Abnormal 11C-Dihydrotetrabenazine ([11C]-DTBZ) PET study to demonstrate nigrostriatal dopaminergic denervation  PD with Dementia (PDD) or dementia with Lewy bodies (DLB). 2. Other disorders which may resemble PD, such as vascular dementia, normal pressure hydrocephalus, multiple system atrophy, corticobasal ganglionic degeneration, or toxic causes of parkinsonism. Prototypical cases have distinctive clinical profiles, like early and severe dysautonomia or appendicular apraxia, which may differentiate them from idiopathic PD. The use of the clinical diagnostic for PD will mitigate the of subjects with atypical parkinsonism. 3. Subjects on benzodiazepine, GABA-ergic medications (baclofen, tizanidine), neuroleptic, anticholinergic (trihexyphenidyl, benztropine), or cholinesterase inhibitor drugs. 4. Evidence of a mass lesion on structural brain imaging (MRI). 5. Participants in whom MRI is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, chest, or cochlear implant. 6. Severe claustrophobia precluding MR or PET imaging. 7. Subjects limited by participation in research procedures involving ionizing radiation. 8. Pregnancy (urine or serum pregnancy test within 48 hours of each PET session) or breastfeeding. 9. History of seizures 10. Significant anxiety or history of panic disorder. 11. History of recent suicide attempt or overdose of tricyclic antidepressants or other medications 12. Any other medical history determined by investigators to preclude safe participation. 13. Allergy to flumazenil 14. Significant liver disease 15. History of alcohol or other substance abuse within past two years. 16. History of regular benzodiazepine use within past year
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-80.0,  Alzheimer Disease For the 3 groups of patients : colonoscopy planned by a gastroenterologist in the context ot the usual medical follow-up of the patient For patients with Alzheimer's disease  Patient with early to moderate Alzheimer disease (continuum of patients with mild cognitive impairment due to Alzheimer's disease and patients diagnosed with probable Alzheimer's disease) according to the National Institute of Aging-Alzheimer's Association (NIA AA) Mini-Mental State Examination (MMSE) score ≥18 Has one informant or care partner No parkinsonian syndrome No sign of lewy Body dementia For patients with Parkinson's disease patients with Parkinson Disease according to the United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) No dementia sign or cognitive deficit associated to Alzheimer's disease For patients without neurodegenerative disease No history or current neurological/degenerative condition (e.g, lewy body dementia, Parkinson's disease, Parkinsonian syndrome, Alzheimer's disease,…) No memory complaint with a Mac Nair score ≤15  For the 3 groups of patients :  History of colonic disorder ((e.g inflammatory condition, adenocarcinoma) contra-indications to colonoscopy For patients with Alzheimer's disease and for patients with Parkinson's disease Any neurological/neurodegenerative condition different from the group to which it belongs (e.g other than Alzheimer's disease for Alzheimer's disease group or other than Parkinson's disease for Parkinson's disease group….) For patients without neurodegenerative disease Any neurological/neurodegenerative condition (e.g lewy body dementia, Parkinsonian syndrome, Parkinson's disease, Alzheimer's disease..) functional colopathy
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Parkinson Disease Diagnosis of idiopathic PD according to the UK BRAIN BANK criteria Age between 18 and 80 years Able to walk 25 meters without help or with minimal assistance and sufficient strength to remain standing for at least 20 minutes without assistance for patient report; Stability of drug therapy for Parkinson's disease for at least 4 weeks before the start of the study Mini-Mental State Examination> 25/30 HAM-D (Hamilton Depression Scale) <17  comorbidity with other neurological disorders heart or orthopedic problems Chronic alcohol abuse
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 35.0-80.0,  Cerebrovascular Disorders Patients identified as stroke and capable of performing voluntary respiratory maneuvers  Increased intracranial pressure Uncontrolled hypertension Complicated arrhythmia Decompensated heart failure Unstable angina Myocardial infarction in the preceding 3 months Pneumothorax, bullae/blebs or infection
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 45.0-999.0,  Arterial Hypertension patients enrolled in stage I to III of systemic arterial hypertension signing the free and informed consent term  patients who do not agree to participate in the study patients with systolic pressure values greater than 180 mmHg or diastolic pressure above 110 mmHg patients with important comorbidities
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Diagnosis of idiopathic, typical Parkinson disease according to the UK Brain Bank Criteria; 2. Hoehn & Yahr stages 1-3 (mild to moderate disease severity); 3. Stable on all PD medications for at least 2 weeks prior to study entry; 4. Willing and able to provide informed consent  < 18 years of age; 2. Pregnant; 3. diagnosis of atypical Parkinsonism; 4. Hoehn & Yahr stages 4-5 5. a score of > 2 on item 7 of the new freezing of gait questionnaire (moderately or significantly disturbing freezing episodes during daily walking); 6. significant cognitive impairment; 7. unstable medical or concomitant illnesses or psychiatric conditions, which in the opinion of the investigators would preclude successful participation; 8. cardiac problems that interfere with ability to safely exercise 9. orthopedic problems in the lower extremities or spine that may limit walking distance; 10. unable to walk for 10 continuous minutes independently; 11. live in an institution or medical facility (i.e. not in the community)
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Parkinson Disease Patients diagnosed with PD by the United Kingdom Parkinson's Disease Society Brain Bank clinical diagnostic or other standard criteria; PD patients detected with positive LRRK2 variants
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease for Parkinson's patients and "related diseases" controls Parkinsonian patients meeting the Gelb Patients with other neurodegenerative disease (such as other Parkinson syndrome or synucleopathies) meeting the set out in Appendix 2 (Lewy Bodies dementia, Parkinson's disease with dementia, MultiSystem atrophy, Progressive Supranuclear Paralysis) , Amyotrophic Lateral Sclerosis, Restless Legs Syndrome, Alzheimer's Disease) Woman of childbearing age having an effective means of contraception Informed consent signed by the subject or his legal representative For demented subjects coming for consultation or day hospitalization with an accompanying person, signature of the legal representative. for of non-ill controls Absence of rest trembling, bradykinesia and stiffness MMSE (Mini Mental State Examination) greater than 25 Woman of childbearing age having an effective means of contraception subject having signed the informed consent  for non-inclusion of patients Clinical for of the diseases described Participation in another therapeutic trial or in the period of a previous clinical trial. for non-inclusion of non-ill controls Functional discomfort in daily life of unknown cause MMSE less than 25 Participation in another therapeutic trial or in the period of a previous clinical trial
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 34.0-74.0,  Prostate Cancer Localized prostate cancer undergoing radical prostatectomy Patient has to understand and be able to write and read Finnish language No prior head injury, dementia or Parkinson's disease No concomitant malignant illness Life expectancy of at least 10 years 74 years of age  Locally advanced prostate cancer (T4) Suspicion or documented metastases (M1) Serum PSA > 20 ng/ml Prior laparoscopic hernia surgery employing non resorbable mesh Prior pelvic irradiation or major surgery Prior malignant disease within prior 5 years excluding skin cancer (non-melanoma)
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 40.0-80.0,  Parkinson's Disease Age from 40 to 60 years, and no limitation of gender. 2. Diagnosis of primary Parkinson's disease(PD) according to Movement Disorder Society (MDS)-PD established in 2015. 3. Hoehn-Yahr Stages from I to IV stage. 4. Drugs for anti Parkinson's disease have been taken over 28 days before entering the group. 5. MMSE score≥25 6. No antidepressant or antipsychotic drugs were received within 2 weeks. 7. Understanding and willingness to sign a written informed consent document  Patients with PD have to be disqualified from this study if any of the following is applicable. 1. Patients with psychiatric history, but depression. 2. Suicidal tendency or behavior of patients. 3. Patients with severe cognitive impairment, chronic organ failure or malignant tumor. 4. The value of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was 1.5 times higher than that of the normal reference; or leucocyte count<1000/μl. 5. Pregnancy and lactating women. 6. The patient is taking part in other drug tests, or received other research medication within 90 days before entering the group. 7. Patients who had quit our study could not enter it again
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 25.0-90.0,  Parkinson Disease, Essential Tremors and Dystonia Dopa responsiveness 2. Minimum disease duration of 5 years. 3. Diagnosis of idiopathic Parkinsons disease 4. Patients with intractable Essential Tremors. 5. Patients with intractable dystonia  Significant medical health problems. 2. Significant cognitive impairment 3. Bleeding tendencies
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  HIV HIV+ and on ART Has moderate or severe household food insecurity Has detectable viral load (>50 copies) and/or suboptimal adherence to ART  Does not meet above