Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-999.0,  Parkinson's Disease Diagnosis of Parkinson's Disease consistent with UK Brain Bank 2. Age at least 30 years old at time of consent 3. Male and Female participants (Women of child-bearing potential (WOCB) are eligible for participation if they are not pregnant or breastfeeding and agree to follow the contraceptive guidance in Appendix 3 during the treatment period and for at least 30 days after the last dose of study treatment) 4. Suitable for oral retainer wear 5. A good response to Levodopa, as assessed by the Investigator 6. At least 2 hours of wearing OFF time per day, as reported by the participant 7. Predictable early morning OFF periods, in the judgement of the participant and the Investigator 8. Taking 400-1,200 mg of LD/CD per day in at least 4 doses, with stable dosing for the last 28 days prior to screening. 9. A modified Hoehn and Yahr of ≤ 3 in the ON state at screening 10. A stable regimen of anti-PD medications for the last 28 days prior to Screening 11. A Mini-Mental State Examination (MMSE) Score ≥26 12. Capable of giving signed informed consent 13. Approved for entry into the study by the Enrollment Authorization Committee (EAC)  Atypical or secondary Parkinson's Disease 2. Severe Dyskinesia that might interfere with study performance in the judgement of Investigator 3. Clinically significant dysphagia or sialorrhea that might interfere with administration of study intervention in the judgement of the Investigator 4. Use of extended release levodopa within 28 days prior to screening 5. Any clinically significant medical, surgical, or psychiatric condition; laboratory value or ECG result which, in the opinion of the Investigator, makes the participant unsuitable for study entry or potentially unable to complete all aspects of the study. 6. Presence of clinically significant orthostatic hypotension at screening, in the opinion of Investigator or the EAC 7. Suicidal ideation within 1 year prior to the Screening Visit as evidenced by answering "yes" to Questions 4 or 5 on the suicidal ideation portion of the Columbia Suicide Severity Rating Scale (C-SSRS) or attempted suicide within the last 5 years. 8. History of psychosis or hallucinations in the past six months 9. Any malignancy in the past 5 years (excluding basal cell carcinoma of the skin or cervical carcinoma in situ that have been successfully treated.) 10. Current or previous diagnosis of malignant melanoma or the presence of any suspicious skin lesion based on physical exam findings 11. Unable to give blood required for the study 12. History of allergic reaction to plastics 13. LD infusion therapy (i.e. Duodopa); current or previous continuous apomorphine infusion treatment. 14. Participation in any other clinical trial <30 days prior to screening visit. 15. Presence of two third molars ("wisdom teeth") on the upper dentition 16. Participants who, for any reason, are judged by the Investigator or the EAC to be inappropriate for this study, including participants who are unable to communicate or cooperate with the Investigator or who have/had a clinically significant illness or abnormal physical examination that may compromise safety of the participant during the trial or affect ability of the participant to adhere to study procedures. 17. Participants taking non-selective monoamine oxidase (MAO) inhibitors 18. Participants with known hypersensitivity to the active ingredients (levodopa, carbidopa) or excipients (Benzoic Acid, Disodium Edetate, Medium Chain Triglycerides, Poloxamer 188) of the drug paste 19. Participants with narrow-angle glaucoma