Patient description: 19 yo Hispanic female G1P1 at 32+ 6 weeks of gestational age presented to the OB clinic for routine follow up complaining of mild headache and leg swelling. Primary evaluation revealed BP of 146/99 and urine dipstick with 3+ proteins. Her BP and U/A were normal in previous visit. Repeat BP a few hours later is 150/100 mmHg. Laboratory studies showed a normal hematocrit, platelet count, and liver transaminase levels. She is complaining of fatigue but no fever or chills. She is also suffering of headaches with no vision changes. No shortness of breath, cough, chest pain, orthopnea and palpitations or skin rash were observed. Her physical exam was negative for abdominal pain, change in bowel habits, nausea, vomiting, dysuria, frequency, hematuria or frothy urine. Leg swelling was observed with no arthralgia or back pain. She has no specific past medical issues and only uses prenatal vitamins. Her family history is positive for DM type 2 and HTN. She is a social alcohol consumer with the negative history of smoking or drug use. She is only have one partner in past 2 years and didn't have any contraceptive methods since 2 years ago. Her BMI was 24 at the first

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Chronic Daily Headache Headache on equal to or more than 15 days per month for at least 6 months; the headaches can be migraine or tension. 2. More than half of the monthly headaches are of moderate or severe intensity on the 4-point categorical pain rating scale and are assessed as 6 or higher on the 11-point numerical pain rating scale. 3. Headaches typically last for at least 4 hours. 4. Subjects are on a stable headache treatment, if any, for at least 2 months  Headache symptoms assessed to be predominately occipital. 2. Allergy to oxytocin. 3. History of addictive behavior (e.g. alcoholism, drug abuse). 4. History of significant psychiatric disorder. 5. History of clinically-significant, functionally-impairing cardiovascular or pulmonary disease. 6. Upper-respiratory tract infection at the time of randomization. 7. Past or current history of any condition that may hinder study procedures or confuse interpretation of data. 8. Nasal obstruction of any cause as determined at screening. 9. Major surgery or trauma within 4 weeks of screening. 10. Women who are pregnant as evidenced by a serum HCG, nursing, or trying to conceive. 11. Use of intranasally administered medications, for example, vasoconstrictors or corticosteroids, within 2 weeks of randomization. 12. Use of an investigational medication or device within 30 days of randomization. 13. Unable or unwilling to adhere to the study-specific procedures and restrictions. 14. Any condition that in the opinion of the investigator would compromise the safety of the subject or the quality of the data. 15. Alanine aminotransaminase (ALT) or aspartate aminotransaminase (AST) equal or greater than 3 times the upper limit of normal (ULN). 16. Serum creatinine of equal or greater than 1.8 mg/dL. Resting, sitting systolic blood pressure equal or greater than 160 mmHg or diastolic blood pressure equal or greater than 100 mmHg at screening. For patients with previously diagnosed hypertension, antihypertensive medications must be stable for at least 30 days prior to screening