semaj83/ctmatch_classification huggingface dataset:
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Foot Ulcer, Diabetic Is the subject 18 years of age or older? Does the subject have a chronic full thickness diabetic foot ulcer (DFU) inferior to the malleolus that has been present for a minimum of four (4) weeks? Does the diabetic foot ulcer measure greater than 1.0 cm2 and less than 25.0 cm2 after the wound is debrided? Does the subject show evidence of neuropathy? Is the subject's wound free of tunneling and showing no exposed periosteum or bone and free of clinical infection defined as the presence of local signs and symptoms including purulence, warmth, tenderness, pain, induration, cellulitis, bullae, crepitus, abscess, fasciitis and osteomyelitis? Is the study wound able to be off loaded or achieve pressure relief and permit daily dressing changes? Is the subject willing to have three (3) wound biopsies taken (Visit 0, 4 and 8)? Is the subject willing to have photos taken of their wound and permit use of the photos in publications? Has the subject or their legally authorized representative signed an Institutional Review Board approved informed consent document and authorized the use and disclosure of protected health information? Does the subject have adequate circulation to the foot as evidenced by an Ankle Brachial Index (ABI) of 0.8  Is the subject pregnant or breast feeding or have they given birth within the 3 weeks preceding the screening visit? Has the subject been diagnosed with a malignant disease and received chemotherapy or treatment for a malignancy within the past 1 year? Does the subject have an infection requiring systemic antibiotic treatment? Has the subject ever received radiation therapy or other local therapy for malignancy at the extremity where the wound is located (from patient history)? Is the subject currently using systemic steroids, or have they used systemic steroids within the previous 2 weeks, or are they projected to require systemic steroid use during the study as evidenced by a history of chronic systemic steroid use? (Topical steroids (except on the study extremity) and steroid inhalants will be allowed in the study.) Does the subject have Lupus or Crohn's disease? Does the subject have an oxygen dependency? Has the subject received hyperbaric oxygen therapy within the previous 90 days? Has the subject had vascular surgery relating to the wound within 30 days prior to the Screening Visit? Does the subject have an active Charcot foot deformity of the foot presenting the ulcer?
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Diabetes Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Healthy FOR TRIAL PART 1, THE Gender: male Age: 18-55 years BMI (body mass index): 18-28 kg/m2 Study participants considered to be healthy FOR TRIAL PART 2, THE Gender: male or female of no childbearing potential Age: 18-65 years Type 1 diabetes: BMI (body mass index): 18-28 kg/m2 Type 2 diabetes: BMI (body mass index): 22-35 kg/m2  Known or suspected allergy to the trial product or related products Presence of illness or infection that may confound the results of the study or pose a risk to the study participant by dosing NN1952, as judged by the Investigator Presence of acute gastrointestinal symptoms (for example nausea, vomiting, heartburn or diarrhoea)
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 21.0-999.0,  Hypercholesterolemia Adults with diabetes LDL greater than or equal to 100 Cholesterol-lowering drug therapy for > 6 months A working telephone At least 2 primary care visits in the past 1.5 years  Poor short-term survival (< 1 year) Inability to understand English Recent major surgery (< 3 months) Patients temporarily in the area Inability to provide consent
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 30.0-70.0,  Type 1 Diabetes Type 2 Diabetes Adult with type 1 or 2 diabetes with or without neuropathy  Pathology affecting bone metabolism abnormalities of phosphate metabolism proved biologically hepatic chronic alcoholism renal insufficiency (creatinine clearance < 60 ml / min) hyperthyroidism intoxication active smoking occlusive arteritis of lower limbs (IPS > IPS 1.2 or < 0.9) Treatment affecting bone metabolism (corticosteroids or glitazones for over 3 months in the year or bisphosphonates within 6 months) Known HIV positive serology Progressive, inflammatory disease (rheumatoid arthritis, ankylosing spondylitis, bowel inflammatory)
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Diabetic Foot Ulcer Patient is 18 years of age or older Patient has type I or II diabetes Foot ulcer has been present for a minimum of 2 weeks under the current investigator's care Foot ulcer is on the plantar surface of the forefoot or heel Ulcer size is >/=1.0 cm2 at Day 0 (day of randomization) Ulcer extends through the dermis and into subcutaneous tissue but without exposure of muscle, tendon, bone, or joint capsule Ulcer is free of necrotic debris, exhibits no signs of clinical infection, and appears to be made up of healthy vascularized tissue Patient's Ankle-Arm Index by Doppler is >/=0.7 Patient has adequate circulation to the foot as evidenced by a palpable pulse Female patients of child bearing potential must not be pregnant and must use accepted means of birth control  There is clinical evidence of gangrene on any part of the affected foot The study ulcer is over a Charcot deformity The study ulcer is due to a nondiabetic etiology The ulcer has tunnels or sinus tracts that cannot be completely debrided The ulcer is >20 cm2 (longest dimension cannot be greater than 5 cm) The ulcer has increased or decreased in size by 50% or more during the screening period Presence of medical condition(s) that in the Investigator's opinion makes the patient an inappropriate candidate for this study Presence of a malignant disease not in remission for 5 years or more Evidence of severe malnutrition, based on a serum albumin level <2.0 Presence of patient having known alcohol or drug abuse
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-90.0,  Pressure Ulcers patient between 18 and 90 years old patients with a non-healing fibrinous wound ≤ 40cm2 (pressure ulcer or venous ulcers pressure ulcers were less than 2cm-deep limb wounds were venous ulcers with an ankle-brachial pressure (ABP)≥ 0.8 signed informed consent  patients pregnant or lactating patients with neuropathy patients perforant ulcer of the foot patients with dementia
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Diabetic Foot Ulcer of Neuropathic Origin Selection Patients who fulfill all of the following (and none of the  described below) are eligible to enter the placebo run-in phase of the study Provide written informed consent to participate Male or female patients age 18 years or older Type 1 or 2 diabetes A single full-thickness DFU that has been present for at least 2 weeks DFU wound surface area below or equal 34 cm2 on the target foot No exposure of bone in the target DFU Neuropathy confirmed by loss of protective sensation to monofilament test (Semmes-Weinstein 5.07 monofilament) No predominant ischemia requiring further exploration or treatment, and confirmed by either ABPI on the target leg ( >0.9;below or equal 1.3) or if ABPI is >1.3 or is not assessable,TBPI on target foot above or equal 0.7, OR
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Cesarean Section Cicatrix Woman having elective or level III caesarean section. Level III caesarean section is defined as being ordered more than 30 minutes before surgery is started Woman who speak and understand Danish Woman who can give informed consent  Level I or II caesarean section (ordered less than 30 min. before surgery is started) Diabetics (this does not gestational diabetes) Infection Regular treatment with immunosuppressives Alcohol or drug abuse Age under 18 Chronic pain disease eg fibromyalgia, rheumatoid arthritis BMI over 35 Previous abdominal surgery through lower transverse abdominal incision (only applicable to woman having caesarean section for the first time)
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-90.0,  Chronic Skin Ulcers Chronic wound needing debridement >3 cm2 Ulcer history >4mo Adequate arterial blood flow (ABI>0.7) Venous, Inflammatory, Pressure, Diabetic  Bleeding disorder ABI<0.7 Uncontrolled diabetes Taking systemic corticosteroids Chemotherapy Participating in another study Treatment with Apligraft, Dermagraft, or Regranex within 90 days
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 49.0-69.0,  Diabetes Mellitus Clinical diagnosis of Diabetes mellitus Must be obese  Previous radiotherapy to the foot previous trauma to the foot (fracture, rupture of tendon) rheumatic or vascular diseases malign diseases lymphatic edema
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-50.0,  Vitamin Deficiency Male and female between 18 years old Immigrants with background from Middle East, Africa and South Asia  Daily use of vitamin D supplementation and frequently use of artificial UV light exposure Pregnancy Malabsorptive disorders Fracture in the leg /arm within the preceding 6 months. Known osteoporosis Tuberculosis, sarcoidosis, cancer, kidney dysfunction, liver dysfunction and history of kidney stone Regular use of medication that interfere with vitamin D/bone metabolism, such as glucocorticoids, diuretics, lithium, antiepileptics, bisphosphonates Regular use of strong pain killers Medication for diabetes
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-90.0,  Lower Limb Ulcer patient with a lower limb ulcer, regardless of origin (arterial, venous or mixed, diabetic foot ulcer) present for more than 6 months or large in size (> 10 cm²) patients in whom the surgeon has recommended that an Integra® matrix be implanted (even if the patient is not taking part in the study) before the dermo-epidermal graft to obtain a richly vascularised neodermis not eligible for skin flap surgery the patient or patient's representative has agreed to sign the information letter before any investigation required by the research  circumferential wound wound infection immunosuppressed patient known allergy to bovine collagen, bovine glycosaminoglycans or silicone patients under legal guardianship pregnant women patients whose health would compromise follow-up for at least 18 months patients whose mental health would compromise completion of the self-evaluation questionnaires wound located in an area not visible by the patient (as no self-assessment would be possible)
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Moderatley to Highly Exuding Venous Leg Ulcers Subject > 18 years Subject is attending weekly office visits at SW Wound Care Center as an out-patient Subject has a moderately to highly exudative venous leg ulcer that would be indicated for treatment with Drawtex Subject or is informed about the trial, understands its nature of the study and provides written informed consent prior to study enrollment Subject is willing and able to comply with all specified care and visit requirements  Subject has a lesion that does not meet the criteria Subject refuses to participate in the study Subject already participates in the this study with one wound (only one wound per subject is allowed) Subject has known sensitivity to the trial product or any of its compounds Subject is expected to be non-compliant Subject's lesion is a primary skin cancer Subject's lesion is the manifestation of a metastasis Subject is pregnant
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Metabolic Syndrome Impaired Glucose Tolerance Gestational Diabetes Dark Skin Tone (Von Luschan chromatic skin color > 35) Age greater than or equal to 45 years Age 18 to 44 years and a BMI > 25 kg/m² with one or more of the following diabetes risk factors Habitually physically inactive (less than 30 minutes of moderate physical activity most, if not all, days of the week) Has a first-degree relative with type 2 diabetes African American, Latino, Native American, Asian American, Pacific Islander Has delivered a baby weighing > 9 lb or previously diagnosed with gestational diabetes Hypertension (≥140/≥ 90 mmHg) or being treated for hypertension HDL cholesterol level < 35 mg/dL and/or a fasting triglyceride level ≥ 250 mg/dL or being treated for dyslipidemia with medication Has been previously diagnosed with Polycystic Ovary Syndrome (PCOS)  Prior participation under VeraLight protocols: VL-2710, VL-2711 or VL-2712 Under 18 years of age Receiving investigational treatments in the past 14 days Psychosocial issues that interfere with an ability to follow study procedures Conditions that cause secondary diabetes including Cushing's syndrome, acromegaly, hemochromatosis, pancreatitis, or cystic fibrosis Diagnosed with any type of diabetes, including type 1 or 2 Taking glucose lowering medications Known to be pregnant Receiving dialysis or having known renal compromise Scars, tattoos, rashes or other disruption/discoloration on the left volar forearm
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Pressure Ulcers ED and ICU admission for critical illness and/or major trauma Over 18 years old  Less than 18 years old Suspected or actual spinal injury Pre-existing sacral or heel pressure ulcer Trauma to sacral and/or heel area
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 40.0-75.0,  Diabetes Mellitus Polyneuropathies Arthropathy, Neurogenic Patients with type 2 diabetes with and without polyneuropathy Patients with type 2 diabetes with a history of Charcot's disease Healthy controls Signed informed consent  Peripheral arterial disease: toe pressure < 70 mm Hg and/or transcutaneous oxygen tension < 40 mm Hg and/or claudication Renal insufficiency: MDRD creatinin clearance < 30 ml/min Systemic disease such as vasculitis or rheumatoid arthritis Malignancy (Diabetic) foot ulcer Gout Bacterial infection of an extremity Skin condition of the dorsal aspect of the foot or the medial side of the upper arm Bleeding disorder such as hemophilia Use of medication for asthma
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Venous Ulcer Infection Is 18 years or older; male or female Previous diagnosis of venous insufficiency proven by a positive venous duplex with reflux Has a venous ulcer with a wound area between 5 cm2 cm2 Has an ankle brachial index (ABI) >0.8 Has a venous ulcer with duration less than 24 months Has a venous ulcer which is critically colonized (not infected) based on the Lazareth Study Model. Ulcers are considered to be critically colonized if at least three of the five following signs are present Severe spontaneous pain between two dressing changes,Perilesional erythema,Local edema,Malodour,Heavy Exudation Is currently using Profore as their standard of care Has not received antibiotics for 6 weeks prior to enrollment  Has an allergy to one of the components of the dressings (calcium alginate, hydrocolloid [carboxymethylceullose], silver) Is currently on antibiotics Has a negative venous duplex Is unable to tolerate 4 layer compression Is unable to continue contact with the investigator for a period of at least two weeks Is unwilling or unable to comply with the study protocol
Patient description: 64-year-old obese female with diagnosis of diabetes mellitus and persistently elevated HbA1c. She is reluctant to see a nutritionist and is not compliant with her diabetes medication or exercise. She complains of a painful skin lesion on the left lower leg. She has tried using topical lotions and creams but the lesion has increased in size and is now oozing.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Lower Extremity Diabetic Leg Wounds Lower Extremity Venous Leg Wounds Lower Extremity Mixed Aetiology Leg Wounds Patient has diabetic foot ulceration, venous ulcer, or mixed aetiology ulcer with a surface area <100 cm2 and <10 cm in widest diameter on lower extremity, but larger than 1 cm2 (venous and mixed aetiology ulcers will be defined by clinical exam of treating physician. Diabetic foot ulcers will be defined by clinical exam of the treating physician and as lower extremity ulcers in patients with a diagnosis of diabetes, but without venous stasis disease) Wound present for >30 days Patient has wound in location amenable to creation of airtight seal around wound using TNP dressings Patient is able to comply with study protocol requirements Patient is able to understand and provide written consent  Patient has evidence of wound infection in the opinion of the physician Patient has a thick eschar that persists after wound debridement Patient has an HbA1C >12% Patient has ulcers due to inflammatory conditions such as pyoderma gangrenosum, rheumatoid arthritis, vasculitis, cryoglobulinaemia, necrobiosis lipoidica, panniculitis, lupus erythematosus, scleroderma, or calcinosis Patient has untreated osteomyelitis Patient has any other condition that, in the opinion of the investigator, makes the patient inappropriate to take part in this study Patient is allergic to the wound care device or occlusive dressing Patient has exposed blood vessels Patient is pregnant or pregnancy is suspected Patient is actively participating in other clinical trials that may interfere with their participation in this study