Patient description: A 53-year-old man presents with chronic HCV infection for the past 2 years. His past medical history is only significant for inguinal hernia surgery when he was 20 years old. He is on IFN (100 mg/week) plus RBV (400 mg/day) combination therapy for the past 9 months. Direct antiviral drugs were added to his treatment 6 months ago. His medical record shows previous positive HCV RNA tests as well as positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 20.0-65.0,  Hepatitis C Virus enrolled voluntarily, can understand and sign informed consent; 2. More than 18 years and less than 65 years; 3. body mass index (BMI) is at 18 4. anti-HCV antibodies and / or HCV RNA positive, and / or other evidence of chronic hepatitis C; 5. HCV RNA level ≥ 2000IU/ml (or equal to this viral load); 6. Women's urine pregnancy test was negative, and the subjects (male subjects) is willing to have no pregnancy plans at next 18 months. (7) ALT is within 6 times of the upper limit of normal  pregnant women, lactating women or plan to pregnant the next 18 months. 2. mental disorder, including history of mental illness (especially the history of depression or depressive tendencies, epilepsy, etc.); 3. The patient who received interferon therapy within the past six months or had no response at previous interferon therapy. 4. The patient who used a strong immune regulator over two weeks with three months before screening, such as adrenocorticotropic hormone, thymosin of α1, thymus 5 peptide. 5. The patient who used hepatotoxic drugs with 6 months before screening, such as dapsone, erythromycin, fluconazole, ketoconazole, rifampin. 6. co-infection with other viruses (HAV, HBV, HEV, the HIV, EBV, CMV) . 7. patients with a history of hepatocellular carcinoma (HCC), or may had hepatocellular carcinoma evidence, such as imaging of suspicious nodules, or AFP abnormal (AFP> 200ng/mL). FibroScan value greater than or equal to F3 at Screening 8. other causes of liver disease: a chronic alcoholic hepatitis, drug-induced hepatitis, autoimmune liver disease, nonalcoholic steatohepatitis. 9. autoimmune diseases, including psoriasis, systemic lupus erythematosus, thrombocytopenic purpura, and so on. 10. heart and vascular system diseases, a history of myocarditis, hypertension, coronary heart disease, pathological arrhythmia, stroke. 11. endocrine system diseases, including thyroid disease, diabetes, etc. 12. pulmonary diseases, including invasive pulmonary disease, pneumonia, shortness of breath. 13. Eye diseases, including retinopathy, retinopathy. 14. chronic infectious disease history (history of tuberculosis). 15. chronic kidney disease, serum creatinine level> 1.5 times upper limit of normal at screening, renal insufficiency, renal anemia history. 16. anemia (including thalassemia, sickle hemoglobin, anemia), and hemophilia. 17. peptic ulcer not controlled, colitis, pancreatitis and others. 18. malignancies. 19. peripheral blood checking: white blood cell count <3 × 109 / L; neutrophil count <1.5 x 109 / L; platelet count <90 × 109 / L; hemoglobin was less than the normal reference limit. 20. serum total bilirubin> 2 times normal maximum reference value (ULN); serum albumin <35g / L; a history of decompensated cirrhosis evidence. 21. evidence of drug addiction (including excessive alcohol intake, average alcohol consumption: men> 40g / day; women> 20g / day, equivalent to 50 degrees white wine 100ml / day and 50ml / day) within one year before screening. 22. a serious history of drug and food allergy, especially towards the test drug (interferon, ribavirin). 23. plans to accept an organ transplant or have organ transplant. 24. participated other clinical trials before 3 months at screening 25. The researchers judged the patients have other factors which may influence the experiment. ribavirin women Hgb <12g/dl or men Hgb <13gdl at screening. 2. anemia patients (eg, thalassemia, spherocytosis hyperlipidemia, gastrointestinal bleeding history) or suspected anemia patients. 3. patients have a history of coronary artery disease or patients with cerebrovascular disease should not join this study, hemoglobin decline up to 4g/dl (it may be observed in the ribavirin treatment)