semaj83/ctmatch_classification huggingface dataset:
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 40.0-80.0,  Macular Degeneration for subjects will be a clear diagnosis of Age-related Macular Degeneration (AMD) for controls will be less than five small (< 63 um) hard drusen At least a 20/40 view of the fundus The ability to provide a blood sample, and the absence of  listed We will individuals with ocular diseases that might simulate Age-related Macular Dengeration (AMD) or preclude its diagnosis Those might prior laser photocoagulation, cryopexy, media opacity, and inflammatory diseases It is important for potential control subjects not to exhibit media opacity (e.g., cataract), which will prevent visualization of the macula Also, subjects will be excluded if they exhibit diseases that phenotypically overlap with Age-related Macular Degeneration (AMD) such as drusen or pigmentary disturbance of the retinal pigment epithelium (RPE), or that provided insufficient evidence to diagnose Age-related Macular Degeneration (AMD) In addition, subjects with pattern dystrophies, toxoplasmosis, histoplasmosis, degenerative myopia, central serous chorioretinopathy, or any disease or treatment that would diminish the ability to recognize drusen such as laser photocoagulation, prior retinal detachment surgery, posterior uveitis, and trauma will be excluded
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 35.0-60.0,  Hypothyroidism Recently diagnosed hypothyroid subject (either during the period, or within the 6 previous months) for whom, data related to the diagnosis is available if the diagnosis was not carried out initially by the investigating doctor Subject, who has given his/her oral consent for participation  Subject included in clinical trial or having participated in a clinical trial during the last 3 months Subject presenting a major and objectifiable risk of not being able to follow-up until the next TSH level (moving, problems encountered during another study, pathology affecting the vital prognosis in the short-term) All contraindications to Lévothyrox
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.538-0.712,  Nursing Care Preterm Infant were included according with the Official Mexican Norm -007-SSA2-1993 (1995)  Preterm Infant were not included in case of malformations that involved lost of the cutaneous integrity or in case of severe cardiac congenital disease
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-49.0,  Phase 1 Safety Study of GelVac™ Nasal Powder H5N1 Influenza Vaccine. able to read and sign Informed Consent Form (ICF) male or female > 18 and < 49 years of age at the time the ICF is signed generally healthy, as determined by medical history and clinical assessment able to attend all scheduled visits and to comply with all trial procedures if female of child-bearing potential, use of an acceptable method of contraception or abstinence for at least 4 weeks prior to the first vaccination through at least four weeks after the second vaccination. Acceptable methods are hormonal birth control or a barrier method with spermicide if female, post menopausal (no menstrual period within the last 12 months), surgically sterile (hysterectomy or tubal ligation), or have a negative urine pregnancy test within 24 hours prior to the time of vaccination  has a known allergy to fruits (e.g., apples, oranges) or pectin and/or pectin by-products (including jams or jellies) has a known allergy to dairy/milk products/lactose is breast-feeding or pregnant or planning on becoming pregnant within 1 month of vaccination has a history of a chronic viral infection (i.e.; Shingles, Herpes Zoster, HIV) has a history of severe allergic reaction following influenza vaccination, systemic hypersensitivity to any of the vaccine components, or history of a life-threatening reaction to a vaccine containing the same substances has a history of demyelinating disease (esp. Guillian-Barre Syndrome) history of Bell's Palsy immunosuppression as a result of underlying illness or treatment use of oral steroids, parenteral steroids, or high-dose inhaled steroids (>800 µg/day of beclomethasone dipropionate or equivalent) within 1 month prior to vaccination use of other immunosuppressive or cytotoxic drugs or radiation therapy within six months prior to vaccination
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.0-5.0,  Hypothyroxinemia Gestational age < 32 WG FT4 (5, 6 or 7 days of life) ≤ 0.8 ng/dL TSH (5, 6 or 7 days of life) < 20 mIU/L Written consent from the parents  Maternal thyroid disease FT4 (5, 6 or 7 days of life) > 0.8 ng/dL TSH (5, 6 or 7 days of life) > 20 mIU/L Grade III or IV intracerebral hemorrhage
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Dyslipidemia Patients >18 years old With Subclinical hypothyroidism defined as serum TSH concentration above 5.0 IU/mL when serum FT4 level is within the reference range With OSA defined as mild OSA: AHI 5 to 15/h; moderate OSA:AHI 15 to 30/h; and severe OSA: AHI greater than 30/h (30) will be enrolled With confirmed sustained subclinical hypothyroidism, thus excluding patients with a temporary condition such as that in recovery from a non-thyroidal illness, measurement of TSH and FT4 will be conducted within four weeks before randomization  Current treatment with Levothyroxine and lipid lowering medications or within two months before randomization Conditions known to cause dyslipidemia e.g. uncontrolled diabetes mellitus (HbA1c >9), alcoholism and some medication use e.g. Estrogens. Glucocorticoids, Retinoids or Interferons Conditions indicating levothyroxine treatment (34); including TSH levels more than 10 mU/l, clear symptoms or signs associated with thyroid failure and not related to OSA . e.g. goiter State of pregnancy, Breast feeding or allergy to levothyroxine
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 3.0-17.0,  Pediatric Solid Organ Transplant Patients Pediatric SOT patients (kidney, liver, heart, lungs, intestine, and/or multi-visceral) Must be at least 6 months after transplant 17 years of age, inclusive Available for duration of study Parent or guardian able to be reached by phone  History of hypersensitivity to previous influenza vaccination or severe hypersensitivity to eggs/egg protein History of Guillian-Barre syndrome Receipt of rituximab within the past one year Rejection treatment with intravenous steroid bolus within 30 days Rejection treatment with monoclonal antibody or antilymphocyte preparation (e.g. Alemtuzumab, Muromonab-CD3, etc.) within 90 days Have any condition that would, in the opinion of the site investigator, place them at an unacceptable risk of injury or render them unable to meet the requirements of the protocol Have any condition that the investigator believes may interfere with successful completion of the study History of received 2011-2012 influenza vaccine Pregnant female History of proven influenza disease after September 1, 2011
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Hypopituitarism All patients with pituitary hypopituitarism  Unavailability of data
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.5-1.5,  Down Syndrome patient with a karyotype demonstrating homogeneous, free or Robertsonian translocation trisomy 21 patient having undergone a cardiac ultrasound not demonstrating any severe heart disease patient aged 6 to 18 months at  congenital hypothyroidism hypothyroidism demonstrated by laboratory tests presenting or having presented hyperthyroidism presenting or having presented leukaemia presenting or having presented West syndrome or any other form of epilepsy or unstable neurological disease presenting or having presented signs of central nervous system distress: stroke, postoperative hypoxia, meningitis) presenting severe heart disease on cardiac ultrasound, with haemodynamic effects presenting non-controlled cardiac arrhythmia Apgar < 7 to 5 min at birth Gestational age < 245 days (35 weeks)
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Group B Streptococcal Infection pregnant women with positive GBS screening culture at 35-37 weeks of gestation singleton gestation subjects with agreement to abstain from the use of any systemic or intravaginal antibiotic, anti-fungal agents, or any other intravaginal product (i.e., contraceptive creams, gels, foams, sponges, lubricants, douches, etc) throughout the trial period  multiple gestations subjects with impaired immunity , diabetes or other significant disease or acute illness that in the investigator's assessment could complicate the evaluation vaginal or systemic antibiotics or antifungal therapy within 2 weeks of the screening visit
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 80.0-999.0,  Hypothyroidism Males and Females aged 80 years or older Diagnosed with hypothyroidism and treated with Levothyroxine for at least 6 months Living independently in the community All TSH results within the range 0.4 U/L in the 3 months before commencing the study Participant has provided written informed consent for participation in the study, prior to any study-specific procedures  Established dementia and therefore deemed incapable of providing informed consent Other medical conditions which, inthe opinion of the Chief Investigator, would prevent them from participating in the study (for example, end stage cancer, severe chronic health conditions where the patient is housebound) Nursing Homes or Residential Care Home residents Individuals with thyroid cancer: since they require high doses of LT4 to suppress their serum TSH Individuals on 25 mcg dailty of LT4: dose reduction will mean that they stop thyroid replacement treatment Non english speaking individuals Participation in any other investigational trials within the last 3 months Participants prescribed medications that can affect thyroid function (amiodarone, lithium, carbimazole or propylthiouracil) Known or suspected lactose intolerance (this would have implications for the proposed over-encapsulated IMP)
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Acute Mountain Sickness Healthy adults  History of serious illness Current smoker or Hemoglobin >15.5gm/dL Uncontrolled hypertension
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Neoplasms Patients must have biopsy-confirmed non-hematological malignancy Patients must be scheduled to receive cytotoxic chemotherapy (adjuvant or metastatic setting), excluding immunotherapy Patients must be of age >=18 years Patients must have an absolute lymphocyte count >= 1,000/mcL immediately prior to influenza vaccination Ability of the patient (or legally authorized representative if applicable) to understand and the willingness to sign a written informed consent document  Patients who have already received the influenza vaccine during the season in which they are considered for will be excluded History of allergic reactions attributed to compounds of similar chemical or biologic composition to the influenza vaccine or egg allergies Previous history of Guillian-Barre syndrome within the previous 6 weeks to influenza vaccination Patients must not be receiving chronic steroid therapy, defined as >= 14 days, unless used as part of a chemotherapy regimen Patients must not be on any other agents that can suppress the immune system Planned concurrent therapy with radiation Uncontrolled illness at time of enrollment or influenza vaccination including, but not limited to, ongoing or active febrile illness Psychiatric illness/social situations that would limit compliance with study requirements Known immunosuppression eg. history of organ transplantation or known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because they may not be able to mount an appropriate immune response History of influenza-like illness, defined as a temperature > 37.8 degree C with cough or sore throat starting October 1, 2011 throughout the duration of the study
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-40.0,  Sprain of Lateral Ligament of Ankle Joint age equal or less than 40 years-old, military subject, acute ankle injury, To have completed and signed the informed consent  contraindications to cryotherapy ( cold allergy, cryoglobulinemia, Raynaud's phenomenon, cutaneous sensory abnormalities, and diabetes mellitus), paracetamol allergy, 4th grade sprains according to the Trevino Classification (with bone wrenching), to take analgesic or anti-inflammatory treatment other than paracetamol
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Women at Risk of Neonatal Infections Colonize With GBS (Group B Streptococci). Patient having a positive vaginal swab for GBS at the end of pregnancy (PCR +) Patient aged over 18 years Patient who received information and agreeing to sign informed consent Patient affiliated or beneficiary of an insurance  Patient does not speak and does not understand French
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Primary Hypothyroidism. Patients will be between the ages of 18 to 65 and will have been on levothyroxine for primary hypothyroidism for at least 6 months  Patients will be excluded if they have the following problems: pregnancy, plan for pregnancy in the next 12 months, cardiac disease, especially coronary artery disease, chronic obstructive lung disease, malabsorption disorder, gastrointestinal surgeries, significant renal or liver dysfunction, seizure disorders, thyroid and non-thyroid active cancers, uncontrolled psychosis, psychotropic medication use, steroid use, amiodarone, chemotherapy for cancer, iron supplement more than 325mg per day, carafate/ proton pump inhibitor use, cholestyramine use, and those with recent PCS orders who are expected to move out of the geographic area, age less than 18 years old or older than 65 years old Patients scheduled for deployment will be excluded
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 8.0-20.0,  Down Syndrome Subclinical Hypothyroidism Males and females, ages 8 years Diagnosis of Down syndrome Subclinical hypothyroidism: TSH level between 5 mIU/L, normal T4 Parental/guardian permission (informed consent) and if appropriate, child assent Females who are at least 11 years of age or who are menarchal must have a negative urine/serum pregnancy test Committed to adherence to levothyroxine treatment and study completion  Pregnancy Type 1/Type 2 diabetes Chronic medical conditions or medication use that can affect growth, nutrition, blood glucose, insulin secretion, or thyroid function (such as lithium or certain seizure medications) Current use of levothyroxine or anti-thyroid hormone Cyanotic congenital heart disease, or pulmonary hypertension (as described by last echo report in subjects with CHD), or congenital heart disease considered medically unstable by the study cardiologists
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Thyroid Cancer Differentiated thyroid cancer treated by thyroidectomy and at least 1 ablation with 131-I > 5 months ago TSH < 4 imU/L  Pregnancy Known metastasis
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 40.0-75.0,  Hypothyroidism Thyroid Diseases Endocrine System Diseases 75 years old Diagnosis of overt or subclinical hypothyroidism in two occasions with a minimum interval period of three months  Pregnant or lactating women Severe hepatic or renal dysfunction Psychiatric disabilities, acute cardiovascular and cerebrovascular diseases, chronic respiratory diseases, familiar hypercholesterolemia, malignancy, cholelithiasis, pancreatitis, bowel diseases and other disorders influencing lipid and bile acid metabolism Taking lipid-lowering agents and other drugs influencing thyroid function, lipid and bile acid metabolism Obviously poor compliance
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Subclinical Hypothyroidism Depression Community-dwelling patients aged >= 65 years with subclinical hypothyroidism Written informed consent  Subjects currently on Levothyroxine or antithyroid drugs, amiodarone or lithium Recent thyroid surgery or radio-iodine (within 12 months) Grade IV NYHA heart failure Prior clinical diagnosis of dementia Recent hospitalisation for major illness or elective surgery (within 4 weeks) Terminal illness Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption Subjects who are participating in ongoing RCTs of therapeutic interventions (including CTIMPs) Plan to move out of the region in which the trial is being conducted within the next 2 years (proposed minimum follow-up period)