Patient description: The patient is a 15 year old girl with the history of recurrent bilateral headache. The attacks come 2 times or more per week and each episode lasts around a day or a half. The pain is pulsating in quality and severe in intensity, causing trouble in her routine physical activity. The attacks are associated with nausea and photophobia. She recently noticed that that there are more attacks around her menstrual period. She is diagnosed with the migraine headache and is under treatment. She is a high-school student and living with her both parents. She is a book worm and spend her free time in a public library near her home. She is also interested in writing stories and has several short stories in English. She rarely does exercise. Her BMI is 21 with the BP of 100/60. There is nothing remarkable in her physical exam.

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Migraine Pain Nausea Vomiting Aura Able to understand and willing to give written informed consent and authorize the Health Insurance Portability and Accountability Act (HIPAA) prior to entering the study. 2. Men and women with episodic migraine who meet the of the International Headache Society's Headache Classification Committee for migraine with or without aura. 3. Between the ages of 18 and 75 years of age, inclusive. 4. A history of episodic migraine for at least 1 year. 5. Maximal frequency of 8 migraine attacks per month; minimum frequency of 2 migraine attacks per month; at least 48 hours of headache-free time between migraine attacks. 6. Maximum total headache days of 14 per month. 7. History of migraine headache with nausea ≥ 50% of the time. 8. Able and willing to complete an electronic diary (eDiary) to record the details of a migraine attack treated with investigational treatment. 9. Able to swallow a capsule whole. 10. Report headache on the Headache Pain Scale at Baseline before treatment. 11. Report the presence of nausea on the Nausea Scale at Baseline before treatment. 12. Women of childbearing potential (WOCBP) must practice an acceptable method of birth control (acceptable methods of birth control in this study surgical sterilization, intrauterine device, oral contraceptive, contraceptive patch, long-acting injectable contraceptive, partner's vasectomy, or a double-barrier method [condom or diaphragm with spermicide]). Use of intrauterine devices and hormonal contraceptives must begin at least 8 weeks prior to Screening. 13. Willing and able to comply with the protocol requirements for the duration of the study  A clinically significant or unstable medical or surgical condition that would preclude safe and complete study participation. Such conditions may cardiac, respiratory, hepatic, renal or metabolic diseases, peripheral vascular disease, any systemic disease, acute infection, or neurological disease (including Parkinson's Disease or other condition associated with a movement disorder), current malignancy or recent history (within 5 years) of malignancy (other than squamous cell or basal cell carcinoma) or any medical condition that, in the opinion of the Investigator, makes the subject unsuitable for participation in the study. 2. A positive saliva screen for alcohol or a positive urine drug screen for cocaine, narcotics, benzodiazepines, opioids, tetrahydrocannabinol (THC), barbiturates, amphetamines, or any prescription drugs unless such a positive result can be explained by stated concomitant medications. 3. Regularly smoke cigarettes or use opiate analgesic drugs, benzodiazepines, ergot containing drugs, alcohol, THC, or other drugs of abuse that, at the discretion of the Investigator, may interfere with the evaluation of the endpoints in the trial. 4. Unstable use of prophylactic migraine medication (eg, change of dose or type of medication) during the 30 days prior to Screening Visit. 5. Subjects using monoamine oxidase-A (MAO-A) inhibitors and who cannot be washed out. 6. Subjects using selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, THC, or systemic corticosteroids over the past month prior to the Screening Visit. 7. Daily use of antipsychotics at least 15 days prior to randomization. 8. Medication overuse: 1. Opioids for headache ≥ 10 days during the 90 days prior to Screening Visit; 2. Combination medications that contain an opioid and/or barbiturate (eg, Fiorinal®) ≥ 10 days during the 90 days prior to Screening Visit. 3. Nonsteroidal anti-inflammatory drugs (NSAIDs) or other simple medications ˃ 14 days a month during the 90 days prior to Screening Visit. 4. Triptans or ergots ≥ 10 days a month during the 90 days prior to Screening Visit. 9. Use of mini prophylaxis for menstrual migraine. 10. History of allergic reaction or drug sensitivity to any triptans. 11. History of allergic reaction or drug sensitivity to promethazine. 12. History of allergic reaction or drug sensitivity to acetaminophen. 13. History of extrapyramidal reaction (eg, akathisia or dystonia) to neuroleptic treatments. 14. Subjects who are pregnant (positive urine hCG: Human chorionic gonadotropin test at Screening Visit) or breastfeeding. 15. Use of experimental or investigational treatments and/or participation in drug clinical studies within the 6 months before the Screening Visit. 16. Subjects who are employees of the Sponsor. 17. Relatives of, or staff directly reporting to, the Investigator