Patient description: The patient is a 55 year old man visiting his primary care physician for lower urinary tract symptoms including frequency, urgency, weak stream, incomplete emptying and intermittent flow for the past 9 months. Further evaluation revealed: IPSS score : 15 Post-void residual: 70 mL Prostate volume (TRUS): 60 mL Prostate-specific antigen (PSA) level: 3.2 ng/mL 10 mL/sec of maximum flow rate when urine volume was 130 mL He is otherwise healthy only using Vit D 1000 units daily. His recent blood chemistry (3 days ago) was normal: Hgb: 13.5 g/dl WBC: 135000 /mm3 Plt: 350000 /ml PT: 11 second PTT: 35 second INR: 0.9 Creatinine: 0.5 mg/dl BUN: 10 mg/dl U/A: Color: yellow Appearance: cloudy PH: 5.3 Specific gravity: 1.010 Glc: 100 Nitrite: negative Ketone: none Leukocyte esterase: negative RBC: negative WBC: 2 WBCs/hpf U/C: negative

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Urethral Stricture Urethral Stricture, Anterior Lower Urinary Tract Symptoms Anterior Urethral Stricture Male subjects ≥ 18 years old 2. Visual confirmation of stricture via cystoscopy or retrograde urethrogram 3. Single lesion bulbar urethral stricture, less than or equal to 3.0 cm 4. Significant symptoms of stricture such as frequency of urination, dysuria, urgency, hematuria, slow flow, feeling of incomplete emptying, recurrent urinary tract infections (UTIs). 5. IPSS score of 13 or higher 6. Lumen diameter <12F by urethrogram 7. Able to complete validated questionnaire independently 8. Qmax <15 ml/sec 9. Guidewire must be able to cross the lesion  Strictures greater than 3.0 cm long 2. Subjects with greater than 1 stricture. 3. Sensitivity to paclitaxel or on medication that may have negative interaction with paclitaxel 4. Previous urethroplasty within the anterior urethra 5. Stricture due to bacterial urethritis 6. Stricture due to untreated gonorrhea 7. Stricture due to Lichen Sclerosus, or balanitis xerotica obliterans (BXO) 8. Stricture dilated or incised within the last 3 months (apart from subjects on self-catheterization) 9. Presence of local adverse factors (e.g. abnormal prostate, urethral false passage or fistula) making catheterization difficult 10. Presence of signs of obstructive voiding symptoms not directly attributable to the stricture at the discretion of the physician 11. Diagnosis of untreated and unresolved severe BPH or bladder neck contracture (BNC), at the discretion of the physician 12. Prior diagnosis of overactive bladder (OAB) 13. Diagnosis of severe stress urinary incontinence (SUI), at the discretion of the physician 14. Previous radical prostatectomy that resulted in either unresolved bladder neck contracture (BNC) and/or unresolved incontinence 15. Previous pelvic radiation 16. Diagnosis of kidney, bladder, urethral or ureteral stones in the last 6 weeks or active stone passage in the past 6 weeks 17. Diagnosed with chronic renal failure, at the discretion of the physician 18. A dependence on Botox (onabotulinumtoxinA) in the urinary system 19. Presence of a penile implant, artificial urinary sphincter, or stent(s) in the urethra or prostate 20. Known neurogenic bladder, sphincter abnormalities, or poor detrusor muscle function 21. Previous hypospadias repair 22. Diagnosis within the last 5 years of carcinoma of the bladder or prostate or suspicion of prostate cancer (e.g. abnormal DRE or high PSA) at the discretion of the physician 23. Any cognitive or psychiatric condition that interferes with or precludes direct and accurate communication with the study investigator regarding the study or affect the ability to complete the study quality of life questionnaires 24. Unwilling to use protected sex for ≥30 days post treatment 25. Unwilling to abstain or use protected sex for 90 days post treatment if sexual partner is of child bearing potential. 26. Inability to provide legally effective Informed Consent Form (ICF) and/or comply with all the required follow-up requirements 27. Active infection in the urinary system 28. History of diabetes not controlled with a hemoglobin A1-C >7.0% 29. Diagnosed or suspected primary neurologic conditions such as multiple sclerosis or Parkinson's disease or other neurological diseases known to affect bladder function, sphincter function or poor detrusor muscle function. 30. Visible hematuria with subject urine sample without known contributing factor