Patient description: The patient is a 47-year-old Asian woman complaining of persistent feelings of sadness. She lost interest in activities she used to enjoy. She states that her mood is mostly depressed for the past 3 weeks. She also lost her appetite , which led to about 5kg weight loss. She complains of loss of energy and feelings of worthlessness nearly every day. She is not using any drugs and she does not smoke. She doesn't drink alcohol. She used to exercise every day for at least 30 min. But she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was recently diagnosed with colon cancer and he is starting his chemotherapy. There is nothing remarkable in her past medical history and her drug history is only positive for Vit D3 1000 units daily. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 30.0-50.0,  Obesity criteria BMI of 30-38 kg/m2 and weight stable over the previous 6 months Satisfied with current weight and not planning to lose weight at the time of enrollment (persons with obesity control group) -or not satisfied with current weight and motivated to lose weight at the time of enrollment (reduced obese groups) No more than 90 min or 3 bouts of planned physical activity/wk Pass a medical and physical screening performed by the study physician Reporting a habitual, regular sleep-wake cycle for the month preceding screening that involved going to bed between 2200 and 0100 h and getting up between 0600 and 0900 h with >7 h and <9.25 h in bed Live or work within 45 minutes of the CU-AMC (reduced obese groups only) (exceptions may be made at the discretion of the Study PI on a case by case basis for highly motivated subjects) Own a smartphone (Android or Apple iOS) For Females   and accept the randomized group assignment (reduced obese groups) Being considered unsafe to participate as determined by the study physician Taking medications affecting weight, triglycerides, or energy intake/energy expenditure in the last 3 months Having abnormal blood chemistry and/or hematology as deemed significant by the study physician Ever having a history of systemic, psychiatric, neurological disease, or drug and alcohol abuse History of cardiovascular disease, diabetes, uncontrolled hypertension, untreated thyroid, renal, hepatic diseases, dyslipidemia or any other medical condition affecting weight or lipid metabolism Score > 18 on Beck Depression Index (BDI) will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study Use of a continuous positive airway pressure (CPAP) device for the treatment of obstructive sleep apnea (OSA). A score of >10 on the Epworth sleepiness scale or >5 on the Pittsburgh Sleep Quality Index will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study Being positive for human immunodeficiency virus or hepatitis B or C History of surgical procedure for weight loss at any time (e.g. gastroplasty, gastric bypass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve)