Patient description: The patient is a 55-year-old man diagnosed with HCV 2 years ago and the recent coinfection with HBV. His past medical history is non-significant. He is on IFN, RBV and direct antiviral drugs for the past 6 months. The patient takes no other medications. His medical records show previous positive HCV RNA tests and a positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis, or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hepatocellular Carcinoma Voluntary agreement to provide written informed consent and the willingness and ability to comply with all aspects of the protocol; 2. Males or females, age ≥ 18 years at the time of informed consent; 3. Imaging (by AASLD or Standard for the diagnosis and treatment of primary liver cancer 2017 in China) or histopathologically or cytologically confirmed advanced HCC; 4. BCLC stage B or C, and not suitable for surgical or local therapy, or has progressed following surgical and/or local therapy; 5. No previous systematic treatment for HCC; 6. Have at least one measurable lesion (in accordance with v1.1); the measurable lesion has a long diameter ≥ 10 mm or lymphadenopathy has a short diameter ≥ 15 mm in spiral CT scan; 7. ECOG-PS score 0 or 1 8. Child-Pugh Class: Grade A 9. Life Expectancy of at least 3 months 10. Subjects with HBV infection: HBV DNA<2000 IU/ml or <10^4 copy/mL, and have received anti-HBV therapy for at least 14 days prior to enrollment in the study, subjects with HCV-RNA(+) must receive antiviral therapy; 11. Hematology and organ functions are sufficient based on the following laboratory results within 14 days prior to the treatment of this study: Whole blood cell examination (no blood transfusion within 14 days, no G-CSF use and no drugs use): WBC ≥ 3.0×10^9/L, HB ≥ 85 g/L; Neutrophils ≥ 1.5×10^9/L; PLT≥75×10^9/L; Biochemical examination (no ALB infused within 14 days): ALB ≥ 29 g/L; ALP and ALT and AST < 5×ULN; TBIL≤3×ULN; Adequate renal function: Cr≤1.5×ULN, or CCr>50mL/min; Female: CrCl = ((140 year) x weight (kg) x 0.85)/72x Cr (mg/dL) Male: CrCl = ((140 year) x weight (kg) x 1.00)/72xCr (mg/dL) 12. Agree to abstain from sex (avoid heterosexual intercourse) or use contraceptive methods with an annual contraceptive failure rate of less than 1% during treatment and for at least 6 months after the last administration  Hepatocellular carcinoma patients with any of the following: Suitable for radical surgery; without an assessment lesion after radical surgery; liver transplantation history or ready for liver transplantation; 2. History of hepatic encephalopathy; 3. Known hepatocholangiocarcinoma, sarcomatoid HCC, mixed cell carcinoma and lamellar cell carcinoma; 4. Pregnant women (positive pregnancy test before taking medicine) or lactating women; 5. Known history of serious allergy to any monoclonal antibody or targeted anti-angiogenic drug (or any excipient); 6. Received any topical treatment within 4 weeks prior to the study, including but not limited to surgery, radiotherapy, hepatic artery embolization, TACE, hepatic artery perfusion, radiofrequency ablation, cryoablation or percutaneous ethanol injection; 7. Previous or existing CTCAE 5.0 standard grade 3 or above gastrointestinal fistula or non-gastrointestinal fistula (such as skin); 8. Factors to affect oral administration and absorption (such as inability to swallow, chronic diarrhea and intestinal obstruction); 9. Ascites with clinical symptoms (i.e. ascites with Child-Pugh rating > 2) or cancerous ascites require therapeutic abdominal puncture or drainage. Or uncontrolled malignant ascites (ascites that researchers believe diuretics or puncture cannot control); 10. Major surgical operations (except biopsy) were performed within 4 weeks prior to the first study of drug therapy or the surgical incision was not completely healed; Minor surgery (i.e. simple resection, biopsy, etc.) was performed within 7 days before the first round of research intervention. 11. Cardiovascular and cerebrovascular diseases with significant clinical significance, including but not limited to acute myocardial infarction, severe/unstable angina pectoris, cerebrovascular accident or transient ischemic attack, congestive heart failure occurred within 6 months prior to admission (New York Heart Association Grade ≥2, see Appendix 4); Arrhythmia requiring antiarrhythmic drugs (except β receptor blocker or digoxin); Repeated ECG detection QTcF interval>480 milliseconds (ms). 12. Hepatic and renal insufficiency, such as jaundice, ascites, and/or bilirubin>3×ULN, creatinine ratio>3.5g/24h, or renal failure requiring blood or peritoneal dialysis, etc. And/or urine routine showed proteinuria ≥++or confirmed 24-hour proteinuria>1.0g. 13. Persistent>2 grade (CTC-AE5.0) infection. 14. History of thromboembolism (including stroke and/or transient ischemic attack) in the past 6 months. 15. Hypertension (systolic blood pressure>160mmHg, diastolic blood pressure>100 mmHg) that not be well controlled through antihypertensive drug treatment. 16. History of active autoimmune diseases or autoimmune diseases in the past two years. 17. Known central nervous system metastasis and/or cancerous meningitis. 18. Be ready for or previously received organ or allogenic bone marrow transplantation. 19. Known history of active tuberculosis (Mycobacterium tuberculosis). 20. History of gastrointestinal hemorrhage within 6 months prior to the start of study treatment or clear tendency of gastrointestinal hemorrhage. 21. History of human immunodeficiency virus (HIV)infection. 22. Active hepatitis B virus or C virus infection and not receive regular treatment; 23. Serious non-healing wound, ulcer or fracture. 24. Drug abuse exists; or any medical, psychological or social condition that may affect research, unstable patient compliance or even endanger patient safety. 25. Any>1 grade (CTC-AE 5.0) unresolved toxicity due to previous treatment or operation, except for hair loss, anemia, and hypothyroidism. 26. Previous and current evidence of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-associated pneumonia and severe impairment of lung function. 27. Received a potent CYP3A4 inhibitor treatment within 7 days prior to the study or received a potent CYP3A4 inducer within 12 days prior to the study. 28. With other active malignant tumors except HCC within 5 years or simultaneously. 29. Patients are unsuitable for participation in this research after comprehensive assessment by the researchers. 30. Patients participate in another clinical study at the same time