Patient description: The patient is a 3-day-old female infant with jaundice that started one day ago. She was born at 34w of gestation and kept in an incubator due to her gestational age. Vital signs were reported as: axillary temperature: 36.3°C, heart rate: 154 beats/min, respiratory rate: 37 breaths/min, and blood pressure: 65/33 mm Hg. Her weight is 2.1 kg, length is 45 cm, and head circumference 32 cm. She presents with yellow sclera and icteric body. Her liver and spleen are normal to palpation. Laboratory results are as follows: Serum total bilirubin: 21.02 mg/dL Direct bilirubin of 2.04 mg/dL AST: 37 U/L ALT: 20 U/L GGT: 745 U/L Alkaline phosphatase: 531 U/L Creatinine: 0.3 mg/dL Urea: 29 mg/dL Na: 147 mEq/L K: 4.5 mEq/L CRP: 3 mg/L Complete blood cell count within the normal range. She is diagnosed with neonatal jaundice that may require phototherapy.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Hepatitis C Subjects must be willing to give written informed consent for the trial and able to adhere to dose and visit schedules Subjects must be willing to give written informed consent for pharmacogenetic testing, and able to adhere to applicable visit schedules Subjects of either gender and of any race between the ages of 18 and 65 years, inclusive, having a Body Mass Index (BMI) between 18 and 32, inclusive. BMI = weight (kg)/height (m)^2. (Individuals with values outside (or indicate lower or higher) of these ranges may be enrolled if clinically acceptable to the investigator and sponsor.) Subjects' clinical laboratory tests (complete blood count [CBC], blood chemistry, and urinalysis) must be within normal limits or clinically acceptable to the investigator and within an allowed expanded range supplied by sponsor. However, subject's liver function test results (ie, aspartate aminotransferase [AST], alanine aminotransferase [ALT]) must not be elevated above normal limits at Screening and on Day -1. No rescreening of liver function tests will be allowed Subjects must be free of any clinically significant disease that would interfere with the study evaluations The Screening 12 lead electrocardiogram [ECG] conduction intervals must be within gender specific normal range (e.g, ECG QTcB,measure in males ≤430 msec and QTcB measure in females ≤450 msec, PR interval ≤200 msec) Vital sign measurements (taken after ~3 minutes in a sitting position) must be within the following ranges: (Individuals with values outside of these ranges may be enrolled if clinically acceptable to the investigator and sponsor.) 1. oral body temperature, between 35.0°C and 37.5°C 2. systolic blood pressure, 90 to 140 mm Hg 3. diastolic blood pressure, 45 to 90 mm Hg 4. pulse rate, 40 to 100 bpm Female subjects must be: 1. postmenopausal (defined as 12 months with no menses, age > 40 years and with a follicle-stimulating hormone [FSH] level of >40 u/mL, and serum E2 < 73 pmol/L), or 2. surgically sterilized at least 3 months prior to baseline (eg, documented hysterectomy or tubal ligation), or 3. premenopausal and if unsterilized must have used a medically accepted method of contraception for 3 months (or abstained from sexual intercourse) prior to the screening period, and agree to use a medically accepted method of contraception during the trial (including the screening period prior to receiving trial medication) and for 2 months after stopping the trial medication. An acceptable method of contraception includes one of the following: i. stable oral, transdermal, injectable, or sustained-release vaginal hormonal contraceptive regimen without breakthrough uterine bleeding for 3 months prior to Screening; in addition, during study use of condom and/or spermicide (when marketed in the country). ii. intrauterine device (inserted at least 2 months prior to Screening visit); in addition, during study use of condom and/or spermicide (when marketed in the country). iii. condom (male or female) with spermicide (when marketed within the country), iv. diaphragm or cervical cap with spermicide (when marketed within the country) and condom (male) Non-vasectomized men must agree to use a condom with spermicide or abstain from sexual intercourse, during the trial and for 1 month after stopping the medication  Female subjects who are pregnant, intend to become pregnant (within 3 months of ending the study), or are breastfeeding Subjects who, in the opinion of the investigator, will not be able to participate optimally in the study Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of any drug. The investigator should be guided by evidence of any of the following, and be discussed with the sponsor prior to enrollment into the trial: 1. history or presence of inflammatory bowel disease, ulcers, gastrointestinal or rectal bleeding; 2. history of major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection; 3. history of pancreatic injury or pancreatitis; 4. history or presence of liver disease or liver injury; 5. history or presence of impaired renal function as indicated by clinically significant elevation in creatinine, blood urea nitrogen [BUN]/urea, urinary albumin, or clinically significant urinary cellular constituents ; or 6. history of urinary obstruction or difficulty in voiding Subject who has a history of any infectious disease within 4 weeks prior to drug administration that in the opinion of the investigator, affects the subject's ability to participate in the trial Subjects who are positive for hepatitis B surface antigen, hepatitis C antibodies or human immunodeficiency virus [HIV] Subjects who have a positive screen for drugs with a high potential for abuse (during the Screening period or clinical conduct of the trial) Subjects with a history of psychiatric or personality disorders that in the opinion of the investigator and sponsor, affects the subject's ability to participate in the trial Subjects with a history of alcohol or drug abuse in the past 2 years Subjects who have donated blood in the past 60 days Subjects who have previously received boceprevir