Patient description: The patient is a 24-year-old man who has had type 1 diabetes for 11 years. He presents to the emergency room with hyperglycemia and concern for possible diabetic ketoacidosis after not taking his insulin for 3 days. The patient reports that he is currently homeless and has lost his supply of insulin, syringes, glucometer, and glucose testing supplies. The patient states that at the time of his initial diagnosis with type 1 diabetes he was hospitalized with a glucose value >1000 mg/dL. At the time, he was experiencing polyuria, polydipsia, and polyphagia. He reports that he has been on insulin since the time of his diagnosis, and he has never been prescribed oral agents for diabetes management. Most recently, he has been using insulin glargine 55 units once daily, and insulin aspart sliding scale 3 times daily. The patient has had previous episodes of diabetic ketoacidosis, for which he was hospitalized. With this episode of hyperglycemia, he is not experiencing any nausea, vomiting, or abdominal discomfort, and he appears well. His lab studies showed: A1c: 11.3% Creatinine: 0.9 mg/dL with eGFR >60 mL/min Aspartate aminotransferase (AST): 17 U/L Alanine aminotransferase (ALT): 14 U/L Beta-hydroxybutyrate: 0.1 mmol/L Bicarbonate: 25 mEq/L Anion

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Type 1 Diabetes Male and female subjects age 18 to 70 years of age. 2. Subjects who are able to provide written informed consent and to comply with study procedures. 3. Clinical history compatible with Type 1 diabetes (onset < 40 yrs old and insulin dependent for > 5 yrs at enrollment, c-peptide negative). 4. Recipients should have absent stimulated c-peptide (< 0.3 ng/mL) in response to a (Boost® 6 mL/kg BW to a maximum of 360 mL; another equivalent product), measured at 60 and 90 min after start of consumption. 5. Subjects who are > 6 months post-renal transplant or >6 months post-liver transplant who are taking appropriate calcineurin inhibitor (CNI) based maintenance immunosuppression ([tacrolimus alone or in conjunction with sirolimus, mycophenolate mofetil, myfortic, or azathioprine; or cyclosporine in conjunction with sirolimus, mycophenolate mofetil, or myfortic ± Prednisone ≤ 10 mg/day). 6. Stable renal function as defined by a creatinine of no more than one third greater than the average creatinine determination performed in the 6 previous months prior to islet transplant, as well as absence of a rejection episode in the 6 months prior to islet transplant 7. Stable liver function tests as defined by: SGOT (AST), SGPT (ALT), alkaline phosphatase values < 1.5, or total bilirubin < 1.5 times normal upper limits at time of study entry, as well as absence of a rejection episode in the 6 months prior to islet transplant  Presence of donor specific anti-HLA antibodies detected by Luminex Single Antigen/specificity bead assay including weakly reactive antibodies that would not be detected by a flow cross match 2. Insulin requirement of >1.0 IU/kg/day 3. Weight more than 100 kg or body mass index (BMI) > 30 kg/m2. 4. Primary hyperparathyroidism OR secondary hyperparathyroidism 5. Untreated or unstable proliferative diabetic retinopathy. 6. Blood Pressure: SBP > 180 mmHg or DBP >100 mmHg despite treatment with antihypertensive agents. 7. Calculated GFR of ≤ 40 mL/min/1.73 m2 using the subject's measured serum creatinine and the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation, as well as presence of a rejection episode in the 6 months prior to islet transplant 8. Elevated liver function tests as defined by: SGOT (AST), SGPT (ALT), alkaline phosphatase values > 1.5, or total bilirubin >1.5 times normal upper limits at time of study entry, as well as presence of a rejection episode in the 6 months prior to islet transplant 9. Proteinuria (albumin/creatinine ratio or ACr > 300mg/g) of new onset since kidney transplantation. 10. For female subjects: Positive pregnancy test, presently breast-feeding, or unwillingness to use effective contraceptive measures for the duration of the study and 4 months after discontinuation. For male subjects: intent to procreate during the duration of the study or within 4 months after discontinuation or unwillingness to use effective measures of contraception. Oral contraceptives, Norplant®, Depo Provera®, and barrier devices with spermicide are acceptable contraceptive methods; condoms used alone are not acceptable. 11. Active infection including hepatitis B, hepatitis C, HIV, or TB. A positive skin test (PPD) in itself is not an and will be followed up by a Quantiferon gold assay. 12. Negative screen for EBV IgG. 13. Invasive aspergillus, histoplasmosis, and coccidioidomycosis infection within 1 year prior to study entry. 14. Any history of malignancy following receiving either the kidney or liver transplant, except for completely resected squamous or basal cell carcinoma of the skin 15. Known active alcohol or substance abuse. 16. Severe co-existing cardiac disease, characterized by any one of these conditions: 1. Recent MI (within past 6 months), 2. Evidence of ischemia on functional cardiac exam within the last year, 3. Left ventricular ejection fraction < 30%, 4. Valvular disease requiring replacement with prosthetic valve. 17. Active infections (except mild skin and nail fungal infections). 18. Active peptic ulcer disease or gastritis, symptomatic gallstones, or portal hypertension. 19. Use of any investigational agents within 4 weeks of enrollment. 20. Administration of live attenuated vaccine(s) within 2 months of enrollment. 21. Any medical condition that, in the opinion of the investigator, will interfere with safe study completion. 22. Positive screen for BK viremia at time of screening. 23. Untreated hyperlipidemia TC > 200 mg/dL, TGC > 200 mg/dL, LDL > 130 mg/dL