Patient description: The patient is a 55-year-old man diagnosed with HCV 2 years ago and the recent coinfection with HBV. His past medical history is non-significant. He is on IFN, RBV and direct antiviral drugs for the past 6 months. The patient takes no other medications. His medical records show previous positive HCV RNA tests and a positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis, or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 20.0-999.0,  Cancer of Liver Patients must meet all of the following in order to be entered into the study: A. Both genders of patients age 20 or older. B. Patients diagnosed of liver cancer (MUST meet at least ONE of the following criteria:) 1. Diagnosed via tumor biopsy by Pathologists, and confirmed by on-service physician. 2. High risk patients (Viral hepatitis B or C or cirrhotics) with typical liver cancer image appeared on more than two radiographic examinations (Ultrasound, MRI, CT scan or Angiography). 3. High risk patients (Viral hepatitis B or C cirrhotics) with evidence of enlarging image of liver cancer via more than two follow-up records. C. In intermediate stage by BCLC staging, tumor size under 8 centimeters, with liver function at Child-Pugh class ≤ 8, and is either difficult to accept an operation or reluctant to accept any operation. D. Disease can be treated by transarterial chemoembolization, and can be evaluated by Ultrasound, Magnetic resonance imaging (MRI), or computed tomography (CT). E. Performance status ECOG 2 or less. Patient has a life expectancy of at least 3 months  If patients meet any of the following they may not be entered into the study: A. major branch of portal vein has been invaded already; extrahepatic metastasis or the the other malignant tumors. B. Evidences of decompensation: Total Bilirubin>2, PT prolong>3 seconds, Child-Pugh class>8, refractory ascites, active bleeding, hepatic encephalopathy, and severe infection. C. Tumor size (diameter) larger than 8 centimeters. D. Not on dialysis with Creatinine >2.0 mg/dL. E. Allergic to iodine or other injections. F. Other main organ failure (Heart, Lung, or Kidney). G. WBC<3000, or Platelet Count <50,000 mg/dL. H. Performance status ECOG of 3 or more. I. Pregnant women and breath feeding women. J. Patients whose blood vessel are too difficult to do Taiwan ACE Beads procedure. K. Prominent AV shunt. L. Severe atherosclerosis. M. Vasospasm or possible major vascular injury. N. Arteriovenous shunt patients, diameter larger than the size of microsphere available. O. Collateral vascular exists and may endanger non-targeted area during arterial chemoembolization. P. Contraindications for doxorubicin. Q. Numerous of tumors locate at different lobes, high risk of Hepatic insufficiency. R. Unwilling to sign a written informed consent form. S. Allergic to pharmaceutical excipients related to Microspheres