Patient description: The patients is a 25-year-old G1 P1 pregnant woman who is 24W3D gestational old who developed a sudden unset of fever and chills, accompany with nausea and vomiting. She also complains of dysuria, urgency and frequency. She also reports some severe pain in the flank. Her vital signs are: T = 39.7ºC, P = 117, R = 20, and BP = 113/74 mm Hg. Physical examination reveals tenderness on palpation of both costovertebral angles. She has no history of recurrent UTI prior to her pregnancy or any other underlying disease. The urine culture showed Gram-negative rod-shaped bacterial cells, leukocytes, and leukocyte casts. The blood culture is negative. A CBC shows Hb 12.9 g/dL, Hct 39%, MCV 76 fL, WBC count 14,120/µL.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Complicated Urinary Tract Infections Adults ≥18 years of age with more than 24 hours of urinary symptoms attributable to a UTI 2. Able to provide informed consent 3. Clinically documented pyelonephritis or complicated urinary tract infection: 1. Pyelonephritis with normal anatomy 2. Complicated UTI as defined by one or more of the following factors: i. The presence of an indwelling catheter ii. >100 mL of residual urine after voiding iii. Neurogenic bladder iv. Obstructive uropathy due to nephrolithiasis, tumor or fibrosis v. Azotemia due to intrinsic renal disease vi. Urinary retention in men possibly due to benign prostatic hypertrophy vii. Surgically modified or abnormal urinary tract anatomy 4. At least two of the following signs or symptoms: 1. Rigors, chills or fever/hypothermia 2. Flank pain or pelvic pain 3. Nausea or vomiting 4. Dysuria, urinary frequency or urinary urgency 5. Costovertebral angle tenderness on physical examination 5. A mid-stream urine specimen with: 1. a dipstick analysis positive for nitrite AND 2. evidence of pyuria as defined by either: i. a dipstick analysis positive for leukocyte esterase AND/OR ii. at least 10 white blood cells per cubic millimeter on microscopic analysis of unspun urine AND/OR iii. White blood cell count ≥10 cells/high-powered field in urine sediment  Receipt of effective antibacterial drug therapy for complicated urinary tract infection (cUTI) for a continuous duration of more than 24 hours during the previous 72 hours. Patients who have objective documentation of clinical progression of cUTI while on antibacterial drug therapy, or patients who received antibacterial drugs for surgical prophylaxis and then develop cUTI, may be appropriate for enrollment. 2. Subjects with an organism isolated from the urine within the last year known to be resistant to ertapenem 3. Severe structural or functional urinary tract abnormality responsible for an intractable infection which in the opinion of the investigator would require > 10 days of therapy or post-treatment prophylaxis (eg. patients with chronic vesiculo-ureteral reflux). 4. Uncomplicated UTI 5. Patients with paraplegia/quadriplegia 6. Hypotension with systolic blood pressure < 90 mm Hg 7. Complicated UTI associated with complete obstruction, emphysematous pyelonephritis, known or suspected renal or perinephric abscess or expected to require surgical intervention (not placement of catheters) to achieve cure 8. Patients with a known history of myasthenia gravis 9. Patients who require concomitant administration of tizanidine or valproic acid 10. Patients with a history of allergy to carbapenems or quinolones or amoxicillin-clavulanate or other beta-lactams, or hypersensitivity to probenecid 11. Renal transplantation 12. Patients requiring dialysis 13. Acute or chronic prostatitis 14. High risk for cUTI caused by Pseudomonas sp. (eg,. history of prior UTI due to Pseudomonas species, recent steroid use, others) 15. Chronic indwelling catheters or stents 16. Ileal loops or vesico-urethral reflux 17. Recent trauma to the pelvis or urinary tract within the prior 30 days 18. History of seizures 19. Patients with a history of blood dyscrasias 20. Patients with a history of uric acid kidney stones 21. Patients with acute gouty attack 22. Patients on chronic methotrexate therapy 23. Females of child-bearing potential who are unable to take adequate contraceptive precautions, have a positive pregnancy test result within 24 hours of study entry, are otherwise known to be pregnant, or are currently breastfeeding an infant. 24. Male subjects must agree to use of an effective barrier method of contraception during the study and for 14 days post treatment 25. Patients known to have a history of liver or kidney disease or neutropenia as defined by the following baseline laboratory Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) > 3 X Upper Limit of Normal Total bilirubin > 2 X Upper Limit of Normal Neutropenia (<1000 cells/mm3) 26. Patients participating in any other clinical study that involved the administration of an investigational medication 27. Patient immunocompromised 28. Patients unlikely to comply with the protocol 29. Patients considered unlikely to survive the 4-week study period or has a rapidly progressive or terminal illness