Patient description: The patient is a 23-year-old man who came to the hospital with high blood pressure (175/95 mmHg) and signs of septicemia. He developed respiratory failure requiring mechanical ventilation and renal failure requiring hemodialysis. His blood smear showed microangiopathic hemolytic anemia and thrombocytopenia. His blood tests revealed elevated lactate dehydrogenase and reduced human complement C3 levels with a normal coagulation profile. He was diagnosed with atypical hemolytic uremic syndrome. He was treated with plasma exchange and corticosteroids. He has been previously vaccinated with meningococcal group ACWY conjugate vaccine and meningococcal group B vaccine. The genetic survey revealed ADAMTS13 >10%.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  HIV/AIDS ESRD Negative HIV antibody testing at screening. 2. For the ESRD requiring HD study group: ESRD requiring chronic hemodialysis for at least 6 months at an established center (not home dialysis). NOTE: The approximate date that hemodialysis was initiated should be reported, if known. For the normal renal function group: Estimated CrCl (using the Cockcroft-Gault equation) at screening >90mL/min. 3. Availability of alternative venous access (not used for dialysis) for the purpose of PK sampling. 4. The following laboratory values obtained within 30 days prior to study entry (obtained either at screening or done as part of routine clinical care) AST (SGOT) and ALT (SGPT) less than or equal to ULN Total bilirubin less than or equal to 1.5 x ULN Hemoglobin greater than or equal to 8.0 mg/dL 5. A negative serum pregnancy test result at screening for all women of reproductive potential who have not reached menopause or undergone hysterectomy, bilateral oophorectomy, or tubal ligation. 6. Males and females, age 18-65 years. 7. Ability and willingness of participant or legal guardian/representative to provide written informed consent  Known allergy or hypersensitivity to either dolutegravir or rilpivirine 2. Use of peritoneal dialysis. 3. Serious illnesses, other than ESRD, requiring systemic treatment and/or hospitalization within 30 days prior to the Screening Visit. 4. Known liver cirrhosis, unstable liver disease (presence of ascites, encephalopathy, coagulopathy, esophageal/gastric varices), Child-Pugh Class A, B, or C, or known biliary abnormalities (except for known Gilbert's syndrome or asymptomatic gallstones). 5. Hepatitis B surface antigen or hepatitis C antibody with detectable RNA at screening. 6. Known gastrointestinal disease that may lead to poor absorption of the study drugs. 7. Known hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption. 8. Any of the following gastrointestinal signs or symptoms of Grade ≥ 2 within 7 days prior to the Screening Visit or during study drug administration prior to the Intensive PK Study Visit nausea vomiting diarrhea abdominal pain 9. Use of any of the following within 30 days of initiating study drug Medications known to appreciably inhibit or induce CYP3A enzymes, P-glycoprotein, or UGT1A1 or UGT1A4 enzymes (e.g., anticonvulsants such as carbamazepine, phenytoin, oxacarbamazepine; antimycobacterials such as rifampin, rifabutin and rifapentine; antifungal agents such as ketoconazole, fluconazole and itraconazole; verapamil, clarithromycin, erythromycin) St. John's Wort, echinacea, grapefruits or grapefruit juice, garlic supplements, ginseng, golden seal, and milk thistle Cancer chemotherapeutic agents Investigational agents Immunomodulators, including systemic steroids greater than or equal to 100 mg/day of prednisone (Note: Topical and inhaled corticosteroids are allowed.)