Patient description: A 5 months old male brought to the pediatrics surgery clinic with the complaint of empty scrotum at the right side. The baby boy is a first child who was born at the age of 38 weeks with NVD from a healthy mother. The mother had a normal pregnancy with no complication. The baby boy weighted 3200 gr with the height of 50 cm. He is breast feeding and now weighted as 6.5 kg with the height of 62 cm. He has no developmental delay in the physical assessment. There is a palpable testis is the left scrotum with non-palpable testis in the right scrotum. The penis is normal in shape and size and he is not circumcised. The diagnostic laparoscopy showed an abdominal undescended testis.

Clinical trial eligibility criteria: eligible ages (years): 0.5-20.0,  Refractory Low-grade Gliomas Recurrent Low-grade Gliomas Written informed consent signed by the patient, or parents or legal representative and assent of the minor child. 2. Age: 6 months to < 21 years of age at time of study entry 3. Histologically confirmed low-grade glioma in non-NF1 patients (no further biopsy is needed at study entry). For patients with NF1 and optic pathway glioma, no biopsy is required to confirm the radiological diagnosis of the low grade glioma. 4. Relapse or refractory tumor after at least one first-line therapy, not taking into account surgery only. 5. Evaluable Disease on morphologic MRI 6. Karnofsky performance status score >=70% for patients >12 years of age, or Lansky score >=70% for patients <=12 years of age, including patients with motor paresis due to disease. 7. Administration of stable dose of steroids for at least one week 8. Life expectancy >= 3 months. 9. Adequate organ function Adequate hematopoietic function: neutrophils ³1.0 x 109/L, platelets ³100 x 109/L; hemoglobin ³8 g/dL Adequate renal function: serum creatinine < 1.5 x ULN for age In others cases where serum creatinine >1.5 ULN according to age, Glomerular filtration rate or creatinine clearance has to be >70 mL/min/1.73 m2 or >70% of the expected value Adequate electrolytes levels: potassium, magnesium, phosphor, total calcium Lower Limit of Normal (LLN) Adequate hepatic function: total bilirubin <=1.5 x ULN; AST and ALT <=2.5 x ULN Absence of peripheral neuropathy >= grade 2 (Common Toxicity Adverse Event, NCI CTCAE v4.0) Adequate cardiac function: Shortening Fraction (SF) >= 28% (35% for children <3 years) and Left Ventricular Ejection Fraction (LVEF) >= 50% at baseline, as determined by echocardiography Absence of QTc prolongation (QTc > 450 msec on baseline ECG, using the QTcF formula) or other clinically significant ventricular or atrial arrhythmia 10. Wash-out period of at least weeks in case of preliminary chemotherapy weeks in case of nitrosourea-containing chemotherapy weeks in the case of treatment with vincristine only  Concomitant anti-tumor treatment 2. Not recovered to <Grade 2 from the acute toxic effects of all prior chemotherapy, immunotherapy or radiotherapy 3. Known intolerance or hypersensitivity to Vinblastine 4. Existence of another severe systemic disease 5. Uncontrolled infections not responsive to antibiotics, antiviral medicines, or antifungal medicines, 6. Any concurrent illness which in the opinion of the investigator may interfere with the treatment and evaluation of the patient 7. Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of nilotinib. 8. Simultaneous treatment with strong cytochromes P450 CYP3A4 inhibitors (e.g. antiepileptic drugs, see complete list in the Appendix 5). 9. Simultaneous treatment with antiarrythmic drugs and other drugs known to prolong QT interval (cloroquine, halofantrine, clarithromycin, haloperidol, methadone, moxifloxacin, bepridil, cisapride and pimozide). A list of QT prolonging compounds can be found at http://www.azcert.org/medical-pros/druglists/drug-lists.cfm (Appendix 6) 10. Impaired cardiac function including any one of the following Clinically significant resting brachycardia (<50 beats per minute) QTc > 450 msec on baseline ECG. If QTc >450 msec and electrolytes are not within normal ranges, electrolytes should be corrected and then the patient re-screened for QTc Other clinically significant uncontrolled heart disease (e.g. unstable angina, congestive heart failure or uncontrolled hypertension) History of or presence of clinically significant ventricular or atrial tachyarrhythmias (including congenital long QT syndrome or a known family history of congenital long QT syndrome)