semaj83/ctmatch_classification huggingface dataset:
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 21.0-80.0,  Dystonia Tremor for Dystonia and/or tremor Diagnosis of Dystonia and/or tremor according to the Consensus Statement of the Movement Disorders Society  Dystonia and/or tremor Pregnancy Active seizure disorder Presence of a metallic object such as a pacemaker, implants, metal rods, and hearing aid History of stroke for Healthy controls There is no history of any neurological disorders for Healthy controls Pregnancy Any neurological disorders Presence of a metallic body in their brain
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-70.0,  Constipation healthy male and female volunteers aged 50-70 years with ≥1 and ≤3 bowel movements per week in the month before the selection visit and in the two weeks before the enrolment visit at least one in four bowel movements had to involve hard faeces or separate lumps of faeces (Bristol scale class 1) in the three months before enrolment  subjects who, in the 30 days before the selection visit or at the time of the visit, had taken drugs, dietary supplements or any foodstuff enhanced in or containing substances, bacteria or yeasts and that might have an effect on the gut and more specifically on intestinal transit, digestive comfort, production of gas, or the occurrence of abdominal pain. Such products were also prohibited throughout the study. The same applied to subjects on a particular diet (vegetarian, vegan, hyper-protein, etc.), a low-calorie diet or under medical treatment which in the investigator's view might interfere with the evaluation of the study (antibiotics, corticoids, anticholinergics, antidepressants, antiemetics, diuretics, calcium channel blockers, antiparkinson drugs, antipsychotics, antacids, analgesics, H2 receptor antagonists, hypnotics, sedatives, iron supplements, opioids and narcotics, laxatives, anti-diarrhoeal drugs, anti-reflux drugs, etc.) subjects who drink more than three glasses of wine a day or two 25 cl glasses of beer a day, or one glass of spirits per day and those who drink more than five cups of coffee per day subjects with a body mass index (BMI) of more than 30 subjects with type I or II diabetes subjects with constipation attributable to an organic or anatomical cause subjects with a history of chronic or inflammatory gastro-intestinal disease subjects with a history of digestive tract operation and especially bariatric surgery subjects with a fibre intake exceeding the recommended levels (more than six portions of fruit and vegetables per day according to the PNNS national nutrition and health programme questionnaire) or engaging in intense sport for more than 10 hours per week
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Vascular Parkinsonism Parkinson's Disease Patients diagnosed with PD or VP, and healthy controls will be included in the study PD diagnosis will be based on the Queen Square Brain Bank for Neurological Disorders clinical and MDS criteria The VP patients will be included if they fulfill the following (Zijlman's diagnostic criteria)Parkinsonism presentation (at least two of the cardinal features: tremors, bradykinesia, rigidity and postural instability). Cerebrovascular disease, defined as evidence of relevant cerebrovascular disease by brain imaging or the presence of focal signs or symptoms consistent with stroke. A relationship between (1) and (2): acute or delayed progressive onset of parkinsonism. Based on the above two forms of VP are suggested: one with acute onset, and another one with insidious progression. The diagnosis will be confirmed by assigning a vascular score. Two points or more are essential to diagnose VP. The points will be assigned as follows Two points: Pathologically or angiographically proven diffuse vascular disease One point: Onset of parkinsonism within 1 month of clinical stroke One point: History of two or more strokes One point: Neuroimaging evidence of vascular disease in two or more vascular territories One point: History of two or more risk factors for stroke (hypertension, smoking, diabetes mellitus, hyperlipidaemia, presence of heart disease associated with stroke [coronary artery disease, atrial fibrillation, congestive heart failure, valvular heart disease, mitral valve prolapse, and other arrhythmias], family history of stroke, history of gout, and peripheral vascular disease)  PD patients with age at onset less than 40 years Any alternative cause that significantly impair gait Inability of the patient to undergo neuroimaging Patients couldn't perform the test or severely demented Atypical and other secondary parkinsonism as patients who had a history of toxin exposure.or antipsychotic drugs treatment by history ,neurological examination and brain MRI  Family or patient's refusal to give written consent
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Acute-On-Chronic Liver Failure Hepatic Encephalopathy Liver transplant recipients who meet all of the following will be enrolled 1. Pre transplant liver failure: Total bilirubin over 171μmol/L and prothrombin activity (PTA)<40%; 2. Overt hepatic encephalopathy(HE): Grade II or higher HE according West Haven classification; 3. HE associated with acute liver failure (Type A) or cirrhosis complicated with portal hypertension and/or portal systemic shunts (Type C)  Patients with a previous history of kidney-related diseases and glomerular filtration rate <30 millilitre per minute; 2. Patients with acute renal failure need CRRT before transplantation; 3. Patients newly developed acute renal failure need CRRT at the time of randomization; 4. Retransplantation or multiple-organs transplantation; 5. Any ischemic or hemorrhagic stroke co-morbidity; 6. Hemodynamic instability requiring fluid resuscitation or very high dose of vasopressors; 7. Extremely moribund patients with an expected life expectancy of less than 24 hours
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 55.0-999.0,  Cognitive Decline Patients  Man or woman 55 years and over Patient received for the first time in Memory Consultation and not aware of his diagnosis Patient with a Mini-Mental State Assessment score (MMSE) ≥ 20 Patient accompanied by a primary caregiver Patient able to provide consent to participate in research Caregiver The caregiver accompanies the patient and is considered as the main caregiver during the consultation is able to provide consent to participate in research  Patient living in a care homes Patient protected by law (under legal protection, guardianship or trusteeship) Patient with a hearing or visual impairment that does not allow to carry out assessments in Memory Consultation Patient opposing research
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 65.0-75.0,  Elderly Subjects from 65 to 75 years old Healthy subjects Having given their written informed consent  Subject who has fallen during the six months prior to the study Subject who moves with walking aids Subject with severe balance problems or unable to stand up without help Subject who takes sedatives or sleeping pills Subject with neurological disease (dizziness including turning dizziness, multiple sclerosis, Parkinson's, etc.) Subject with history of heart attack Subject who is short of breath when inactive Subject who has pains limiting walking and standing Subject who takes neuroleptics except Anti-depressors if the treatment is long-standing and well-balanced
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-70.0,  Myocardial Infarction, Acute Myocardial Strain Arterial Stiffness Quality of Life Signed Informed Consent Form 2 Presence of documented STEMI or / repeated STEMI or of LV anterior wall confirmed by ECG, troponin I and CPK-MB levels, coronary angiography. 3. Presence of hemodynamically relevant stenosis of LAD or its branches (diagonal, septal) as an infarct-related artery confirmed by CAG  Presence of hemodynamically relevant stenosis exceeding 30% in several coronary arteries confirmed by CAG; 2. A history of primary STEMI or of the LV posterior wall 3. Exogenous hypertriglyceridemia (type 1 hyperchilomicronemia). 4. The development of acute heart failure III-IV prior to randomization 5. Individual intolerance to statins, ezetimibe. 6. Congenital and acquired heart diseases. 7. Severe concomitant diseases in the stage of decompensation. 8. Non-sinus rhythm, established artificial pacemaker. 9. Sinoatrial and atrioventricular blockade of 2-3 degrees. 10. QRS complex exceeding 100 ms. 11. The presence of severe LV hypertrophy according to echocardiography. 12. Uncontrolled hypertension with SBP> 180 mm Hg and DBP> 110 mmHg 13. Diabetes mellitus (DM) type 1 and 2. 14. Current existence of severe anemia (Hb < 100 g/L) 15. Chronic kidney disease (creatinine clearance less than 30 ml / min / 1.73 m2 according to the CKD-EPI). 16. Non-corrected thyroid dysfunction with hyper / hypothyroidism. 17. Body mass index (BMI) ≥35 kg / m2. 18. Pregnancy, lactation. 19. Alcohol abuse, drug addiction. 20. Other serious concomitant diseases that the possibility of study participation. 21. Participation in other clinical trials within the last two months
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-999.0,  Parkinson Disease aged 50 years or older Parkinson Disease Diagnosis Hoehn-Yahr score between 1-3 independently walk at least 3 meters cognitive ability to follow simple commands  Montreal Cognitive Assessment score less than or equal to 22 diagnosis of other severe comorbidities contraindications to physical activity
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-80.0,  Parkinson Disease Key Diagnosis of clinically established or clinically probable PD according to MDS-PD with at least 1 year of PD symptoms Modified Hoehn and Yahr ≤2.5 Have notable motor worsening during off-medication state Clear-cut improvement of motor response to levodopa medications, as assessed by the investigator Must be on stable dopaminergic therapy (e.g., levodopa, dopamine agonists, monoamine oxidase inhibitors, catechol-O-methyl transferase inhibitors, amantadine), for at least 8 weeks prior to enrollment and remain on stable dose during the 12-week treatment period Female subjects must not be pregnant or breastfeeding. Women of childbearing potential (WOCBP) must have a negative pregnancy test at Screening. WOCBP must agree to use highly effective contraception prior to study entry. Male subjects must be willing to use a barrier method of contraception. Key  Secondary or atypical parkinsonian syndromes, for example, patients with parkinsonism from encephalitis, metabolic disorders, vascular parkinsonism, drug-induced parkinsonism, multiple system atrophy, corticobasal ganglia degeneration, progressive supranuclear palsy, Lewy body dementia History of any brain surgery for PD (e.g., pallidotomy, deep brain stimulation, or fetal tissue transplant) Conditions affecting the peripheral or central nervous system, unless related to PD, that would affect the ability to adequately perform the MDS-UPDRS and motor assessments: i.e., severe sensory neuropathy affecting arm or leg function, or stroke affecting motor or gait function Significant alcohol or drug abuse within past 2 years Based on ECG reading, subjects with a risk of QT prolongation. NOTE: Other protocol defined Inclusion/
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Parkinson's Disease Psychosis Veteran Diagnosis of idiopathic PD for 2 or more years Psychosis [with Neuropsychiatric Inventory (NPI) hallucinations (B) or delusions (A) score 4 or greater] Stable dose of PD medications for at least 1 month If on an acetylcholinesterase inhibitor (AChEI) initially prescribed at least 3 months prior and stable dose (no dose or medication change) for past month Informed other must provide informed consent and agree to attend all study visits. The informed other must be at least 18 years of age and have regular in-person contact with the patient (at least 5 days per week, and at least 4 hours per day that is spent with patient) English-speaking  Psychosis symptoms severe enough to preclude enrollment in a clinical trial and require prompt clinical care instead Treatment with an antipsychotic, including pimavanserin in the past year, except quetiapine <50 mg/day which has been discontinued for at least 1 month prior to study enrollment Deep brain stimulation (DBS) surgery occurring within 6 months prior or having unstable stimulator settings in the previous month History of a psychotic disorder prior to PD, including schizophrenia and bipolar disorder Suspected atypical parkinsonian disorder or dementia with Lewy bodies (DLB) Psychosis secondary to other toxic or metabolic disorder Congestive heart failure History of stroke within the last 6 months History of myocardial infarction within the last 6 months History of long QT syndrome or prolonged QTc [>450ms in men, >470ms in women] at screening/baseline (or baseline, if applicable)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-999.0,  Parkinson's Disease (PD) Participants who have Parkinson's Disease and who have successfully completed the parent study M15-741 Participants willing and able to comply with procedures required in the protocol  Participants, if judged by the investigator to be unsuitable candidates to continue to receive ABBV-951 for any reason