Patient description: The patient is a 34-year-old obese woman who comes to the clinic with weight concerns. She is 165 cm tall, and her weight is 113 kg (BMI: 41.5). In the past, she unsuccessfully used antiobesity agents and appetite suppressants. She is complaining of sleep apnea, PCO and dissatisfaction with her body shape. She is a high-school teacher. She is married for 5 years. She doesn't use any contraceptive methods for the past 4 months and she had no prior pregnancies. She rarely exercises and movement seems to be hard for her. She is not able to complete the four-square step test in less than 15 seconds. She does not smoke or use any drugs. Her BP: 130/80, HR: 195/min and her BMI is: 41.54. Her lab results: FBS: 98 mg/dl TG: 150 mg/dl Cholesterol: 180 mg/dl LDL: 90 mg/dl HDL: 35 mg/dl She is considering a laparoscopic gastric bypass.

Clinical trial eligibility criteria: eligible ages (years): 19.0-45.0,  Rhinitis, Allergic, Perennial Healthy male in the age of 19-45 2. Body weight ≥ 50kg, BMI 18~29 kg/m2 3. Subject who sign on an informed consent form willingly  Subject with serious active cardiovascular, respiratory, hepatologic, renal, hematologic, gastrointestinal, immunologic, dermal, neurologic, or psychological disease or history of such disease 2. Subject with acute disease within 28 days prior to study medication dosing 3. Subject with known for history of disease which affect on the absorption, distribution, metabolism, excretion of drug 4. Subject with clinically significant chronic disease 5. Positive on the test of HBs Ag, anti-HCV Ab, anti-HIV Ab, VDRL 6. Use of any prescription medication within 14 days prior to study medication dosing 7. Use of any medication such as over-the-counter medication including oriental medication within 7 days prior to study medication dosing 8. Subject with clinically significant allergic disease 9. Subject with known for hypersensitivity reaction to bepotastine 10. Subject with any of the following conditions in laboratory test AST/ALT > UNL (upper normal limit) x 2 Total bilirubin > UNL x 2 Renal failure with CLcr < 50mL/min calculated on Cockcroft-Gault [Cockcroft-Gault GFR = (140-age) * (Wt in kg) / (72 *Cr)] SBP<100mmHg or ≥160mmHg, DBP<60mmHg or ≥100mmHg QTc>440msec on ECG Serum potassium < 3.5 mEq/L or > 5.5 mEq/L 11. Immunological incompetence, immune deficiency or taking immunosuppressants 12. Subject who cannot take standard meal 13. Subject with whole blood donation within 60days, component blood donation within 20days prior to study medication dosing 14. Subject with blood transfusion within 30days prior to study medication dosing 15. Participation in any clinical investigation within 90days prior to study medication dosing 16. Continued excessive use of caffeine (caffeine >five cups/day), alcohol(alcohol>30g/day) and severe heavy smoker(cigarette >10 cigarettes per day) 17. Subject with decision of nonparticipation through investigator's review due to laboratory test results or other excuse such as non-responding to request or instruction by investigator 18. Subject taking inducer or inhibitor of drug metabolism enzyme such as barbital within 30days prior to study medication dosing 19. Subject who are not using adequate means of contraception 20. Subject with genetic problems such as galactose intolerance, Lapp Lactase Deficiency or glucose-galactose malabsorption 21. Subject with history of drug abuse or drug addiction