semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 12.0-999.0,  Wilson Disease Male or female ≥ 12 years of age at the time written informed consent is provided. 2. Confirmed diagnosis of Wilson disease. 3. Have a documented history of copper chelator (ie, penicillamine, trientine) and/or zinc therapy or be ≥ 1 year post liver transplant with no active associated complications. 4. Willing and able to comply with all study procedures and requirements. If < 18 years of age (or as required by region), have a caregiver who is willing and able to assist with study requirements if needed. 5. Willing and able to provide written informed consent after the study has been explained and before any study-related data are collected or study-related procedures are performed. If < 18 years of age (or as required by region), willing and able to provide written assent and have a legally authorized representative who is willing and able to provide written informed consent after the study has been explained and before any study-related data are collected or study-related procedures are performed  History of liver disease due to a medical condition unrelated to Wilson disease. 2. Liver fibrosis stage F3 or F4. 3. Decompensated hepatic cirrhosis and/or evidence of portal hypertension. 4. Marked neurological disease requiring either nasogastric feeding or intensive inpatient medical care. 5. Female subject who is pregnant or breastfeeding or who plans to become pregnant at any time during the study. 6. Female subject of childbearing potential who has a positive urine pregnancy test on Day 1 or is unwilling to have additional pregnancy tests during the study. 7. Current or previous participation in a gene transfer study. 8. Presence or history of any disease or condition that, in the Investigator's opinion, would interfere with the subject's safety or ability to participate in the study or significantly affect interpretation of study results
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 50.0-75.0,  Parkinson's Disease For early PD patients Clinical diagnosis of "probable PD" by two neurologists specializing in movement disorders according to the International Parkinson and Movement Disorder Society (MDS) Clinical Diagnostic for PD (2015) Age 50-75, disease duration is less than 1 year, and Hoehn & Yahr Stage I the dopamine reuptake transporter (DAT) is significantly reduced in striatum on PET imaging Metabolic brain network detected by fluorine-18-labelled-fluorodeoxyglucose-PET(18F-FDG PET) is consistent with Parkinson's disease-related pattern (PDRP), with FDG hypermetabolism being in basal ganglia and cerebellum Good response to anti-PD medications Ability of completing questionnaires Ability of providing informed consent Willingness of being assessed by neurologists during off-medication state defined as discontinuing anti-PD medications for at least 12 hours before assessment  Secondary parkinsonism (ie. drug induced) Atypical parkinsonisms like MSA or PSP etc Presence of any item in 10 red flags of the MDS Clinical Diagnostic for PD (2015) in the comprehensive assessments during follow-up History of being diagnosed as any cancer within 5 years Presence of any condition risking the procedure of performing lumbar puncture (LP) Pregnancy Inability to comply with study procedures. For early MSA patients Clinical diagnosis of "probable MSA" by two neurologists specializing in movement disorders according to the International Parkinson and Movement Disorder Society (MDS) second consensus for MSA (2019) Age 50-75, and disease duration is less than 1 year Metabolic brain network detected by fluorine-18-labelled-fluorodeoxyglucose-PET(18F-FDG PET) is consistent with MSA related pattern
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Wilson's Disease Main Male or female aged between 18 and 60 years Patient diagnosed with WD, as historically established and documented by Leipzig score ≥ 4, as per the 2012 EASL Clinical Practice Guidelines (EASL, 2012) and genetically confirmed Treated for WD according to international recommendations with no current evidence for inadequate treatment (EASL, 2012; Roberts et al, 2008) Stable WD for ≥ 1 year, defined as: (i) No significant change in neurologic examination and in status of mood disorder,and (ii) stable laboratory parameters used to assess copper metabolism including 24-hour urinary copper, non-ceruloplasmin copper (NCC), as well as liver enzymes, hemoglobin, and white blood cell count Main  ALT level (mean of 2 measurements ≥ 1-week apart) > ULN or either of the 2 measurements > 1.5 x ULN Total bilirubin > 1.5 x ULN in the absence of proven Gilbert's syndrome; in case of Gilbert's syndrome, direct bilirubin > ULN INR > ULN Any signs of liver cirrhosis decompensation, including gastrointestinal bleed within 6 months (24 weeks) prior to screening/enrolment visit Patient has moderate or severe renal impairment or patient has nephritis or nephrotic syndrome Any history or current evidence of HIV-1, HIV-2, HTLV 1, or HTLV-2 infection Any history or current evidence of hepatitis B infection Any history of hepatitis C infection, unless previous viral RNA assays in two samples, collected at least 6 months apart, are negative Positive QuantiFERON®-TB Gold tuberculosis test result Any concomitant disorder/condition
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Healthy Be at least 18 years old Be able to walk and/or lift heavy objects without pain/discomfort  Have prior back/neck injuries or chronic pain in the last 6 months Have a pacemakers Have breast implants Have removed the axillary lymph nodes Pregnant women Using blood thinning medications Participants must consult a physician prior to participating this study if any of the following occurred before or during use: Inguinal hernia, hernia, knee injury hip/knee prosthesis, hyperextended knee, recent surgery, skin disease/injury, scars, inflammation, skin reddening
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 22.0-99.0,  Movement Disorders Men and women age 22 years or older; 2. A diagnosis of ET and PD as confirmed from clinical history and examination by a neurologist or neurosurgeon specialized in movement disorder; 3. Intolerance to side effects of medication or poor response to medication, severe and disabling tremor; 4. Regarding PD patients, the ratio of mean Unified Parkinson Disease Rating Scale (UPDRS) tremor scores to the mean UPDRS postural instability/gait disorder scores equal or greater than 1.5; 5. Able to communicate sensations during the ExAblate TcMRgFUS treatment; 6. All MRI examination performed according to study protocol; 7. Having complete medical history and clinical follow up; 8. Imaging data can be processed  Subjects with unstable cardiac status; 2. Severe hypertension (diastolic BP > 100 on medication); 3. Subjects with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including cardiac pacemakers, size limitations, etc; 4. Known intolerance or allergies to the MRI contrast agent (e.g. Gadolinium or Magnevist) including advanced kidney disease; 5. Patient with severely impaired renal function; 6. History of abnormal bleeding and/or coagulopathy; 7. History of immunocompromise including those who are HIV positive; 8. History of intracranial hemorrhage; 9. Cerebrovascular disease (multiple CVA or CVA within 6 months); 10. Subjects with uncontrolled symptoms and signs of increased intracranial pressure (e.g., headache, nausea, vomiting, lethargy, papilledema); 11. Individuals who are not able or willing to tolerate the required prolonged stationary supine position during treatment (can be up to 4 hrs of total table time); 12. Significant claustrophobia that cannot be managed with mild medication; 13. Presence of any other neurodegenerative disease such as Parkinson-plus syndromes suspected on neurological examination; 14. Presence of significant cognitive impairment; 15. Subjects with life-threatening systemic disease; 16. Subjects with a history of seizures within the past year; 17. Subjects with presence or history of psychosis. -
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Wilson Disease Diagnosis of WD by Leipzig > 4. 2. Able to reside in the clinical research unit for intensive metabolic monitoring of copper and molybdenum. 3. Participants willing to adhere to copper/molybdenum-controlled diet during the study. 4. Willing and able to follow protocol-specified contraception requirements. 5. Capable of giving signed informed consent  Decompensated cirrhosis or model for end stage liver disease score > 13. 2. Modified Nazer score > 7. 3. Clinically significant gastrointestinal bleed within past 3 months. 4. Alanine aminotransferase > 2 × upper limit of normal. 5. Hemoglobin less than lower limit of the reference range for age and sex. 6. Significant medical history (current or past). 7. Previous treatment with zinc within 30 days prior to the Screening Visit. 8. Participants in renal failure, defined as in end-stage renal disease on dialysis (chronic kidney disease stage 5) or creatinine clearance < 30 milliliters/minute
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Rheumatic Heart Disease Valvular Disease ≥ 18 years History of RHD as evidenced by at least one echocardiographic examination No history of cardiac surgery  ≥ 75 or < 18 years old Absence of RHD or RF history Active liver disease Impaired hepatic and renal function, including unexplained elevated levels of alanine transaminase greater than twice the upper limit of normal History of previous statin intolerance or muscle disorders Current pregnancy (by history or lab assessment of beta hCG) or plans for pregnancy in the next 18 months). Current lactation / breast feeding LDL <60
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 50.0-999.0,  Essential Tremor Parkinson Disease Essential Tremor Subjects must be 50 years of age or older Subjects must have been diagnosed with Essential Tremor Subjects must live within 3 hours of UTSW Parkinson's Disease Subjects must be 50 years of age or older Subjects must have been diagnosed with Parkinson's Disease Subjects must live within 3 hours of UTSW Healthy Individuals Healthy individuals living within 3 hours of UTSW  Healthy Individuals Subjects with medical history of neurological conditions Subjects with family history of neurological condition Subjects with spouse diagnosed with Essential Tremor or Parkinson's Disease Essential Tremor Subjects with medical history of another movement disorder such as Parkinson's Disease or dystonia Subjects with head tremor that preceded hand tremor Parkinson's Disease --Subjects with medical history of Essential Tremor Essential Tremor and Parkinson's Disease that does not meet
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Acute Hyperkalemia Oral Potassium Binders Plasma potassium > 5.5 mEq/L Age ≥18 years Patient able to provide written informed consent  Recent bowel surgery Ileus or bowel obstruction Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis Pregnancy Active psychiatric disorder Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option Dialysis session expected within 4 hours after randomization History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Healthy Have regular bowel movements (at least once per day). 2. Adequate venous access in the left or right arm to allow collection of study-required blood samples. 3. Willing and able to adhere to all dietary requirements of the study. 4. Body weight between 50 to 70 kilograms (kg) (inclusive) for female participants, and 65 to 85 kg (inclusive) for male participants, and body mass index within the range 18 to 25 kg/meters squared (inclusive). 5. Willing and able to follow protocol-specified contraception requirements. 6. Capable of giving signed informed consent  Significant medical history (current or past). 2. History or presence of gastrointestinal conditions including chronic constipation and irritable bowel syndrome. 3. Supine blood pressure ≤ 90/60 millimeters of mercury (mmHg) or > 140/90 mmHg. 4. Lymphoma, leukemia, or any malignancy within 3 years. 5. Breast cancer within the past 10 years. 6. Alanine aminotransferase, aspartate aminotransferase, or total bilirubin > upper limit of normal at Screening. 7. Serum copper or serum ceruloplasmin below lower limit of normal on laboratory reference range at Screening. 8. History of anemia or hemoglobin < 130 gram (g)/Liter (L) for men and hemoglobin < 115 g/L for women at Screening. 9. History of benign ethnic neutropenia or absolute neutrophil count < 1500/microliter (uL); lymphocyte count below 1000/uL. 10. QTcF> 450 millisecond (ms) for men and QTcF> 480 ms for women. 11. Current or chronic history of liver disease or known hepatic or biliary abnormalities (except for asymptomatic gallstones)
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Coronary Artery Disease Intestinal Disease Coronary heart disease verified by coronary angiography  Current infection requiring intravenous antibiotics Inflammatory bowel disease Renal failure with creatinine > 200µmol/L Hepatic impairment Pregnancy Previous bariatric surgery Colostomy Active malignant disease
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Gangliosidoses GM1 Gangliosidosis Morquio B Disease Sialidosis Galactosialidosis Gm2-Gangliosidosis, Variant B1 Tay-Sachs Disease Sandhoff Disease GM2 Activator Deficiency Biochemically and/or genetically affirmed diagnosis of a gangliosidosis The patient or respectively the parents or the caregiver (for children or older underage patients) have given written informed consent  The diagnosis of a gangliosidosis has not biochemically or genetically confirmed A written informed consent of the patient or parents/acaregiver does not exist