Patient description: The patient is a 55-year-old man diagnosed with HCV 2 years ago and the recent coinfection with HBV. His past medical history is non-significant. He is on IFN, RBV and direct antiviral drugs for the past 6 months. The patient takes no other medications. His medical records show previous positive HCV RNA tests and a positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis, or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Pharmacokinetic and Tolerability of Finafloxacin Healthy adult male and/or female, 18 to 35 years of age (inclusive), or 65 years or over(≥ 65 years) Body mass index (BMI) ≥ 18 and ≤ 30 kg/m2 No clinically significant abnormal findings, as judged by the Principal Investigator (PI), on the physical examination, ECG, medical history, or clinical laboratory results during screening Negative screen for human immunodeficiency virus (HIV), hepatitis B, C and/or positive hepatitis B surface antigen (HBsAg), and anti-Hepatitis C virus (HCV) antibodies Females of childbearing potential were either sexually inactive (abstinent) for 14 days prior to the first dose and throughout the study or were using one of the following acceptable birth control methods: 1. Surgically sterile (bilateral tubal ligation, hysterectomy, bilateral oophorectomy) for a minimum of 6 months. 2. Intrauterine device (IUD) in place for at least 3 months. 3. Barrier methods (condom and diaphragm) plus spermicide for at least 14 days prior to the first dose and throughout the study. 4. Surgical sterilization of the partner (vasectomy for 6 months minimum). 5. Hormonal contraceptives for at least 3 months prior to the first dose of the study and throughout the study Females of non-childbearing potential were either postmenopausal for at least 2 consecutive years prior to Day 1, with a follicle-stimulating hormone (FSH) level > 40 IU/mL or had undergone one of the following sterilization procedures at least 6 months prior to Day 1: 1. Bilateral tubal ligation. 2. Hysterectomy. 3. Hysterectomy with unilateral or bilateral oophorectomy. 4. Bilateral oophorectomy Male subjects were either sexually inactive (abstinent) or using a barrier method for 14 days prior to the first dose and throughout the study In addition, male subjects and female subjects of childbearing potential were advised to remain sexually inactive or to keep the same birth control method for at least 30 days in the case of females and 90 days in the case of males, following the last dose. Male subjects were additionally advised not to donate sperm for 90 days following the last dose Was able to understand and willing to sign an ICF  Subject with psychiatric, neurological, or behavioral disorders that may have interfered with the conduct or interpretation of the study Subject with a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, or hematological disorders that were capable of significantly altering the absorption, metabolism, or elimination of drugs, or were considered a risk with the study medication or could have interfered with the interpretation of data Subject who had an abnormality in the 12-lead ECG that, in the opinion of the PI, increased the risks associated with participating in the study Subject with clinically relevant abnormal laboratory data or vital signs at screening, or any abnormal laboratory value which, in the opinion of the PI, could have interfered with the assessment of safety Subject with exposure to any investigational drug within 30 days prior to screening Subject with a known hypersensitivity or other contraindication to the use of fluoroquinolones Subject with a history of tendon rupture or tendonitis Subject who received corticosteroid therapy in the 4 weeks prior to study drug administration Subject with prior participation in a finafloxacin investigational study Subject who had current diagnosis or known history of drug and/or alcohol abuse