Patient description: The patient is a 34-year-old obese woman who comes to the clinic with weight concerns. She is 165 cm tall, and her weight is 113 kg (BMI: 41.5). In the past, she unsuccessfully used antiobesity agents and appetite suppressants. She is complaining of sleep apnea, PCO and dissatisfaction with her body shape. She is a high-school teacher. She is married for 5 years. She doesn't use any contraceptive methods for the past 4 months and she had no prior pregnancies. She rarely exercises and movement seems to be hard for her. She is not able to complete the four-square step test in less than 15 seconds. She does not smoke or use any drugs. Her BP: 130/80, HR: 195/min and her BMI is: 41.54. Her lab results: FBS: 98 mg/dl TG: 150 mg/dl Cholesterol: 180 mg/dl LDL: 90 mg/dl HDL: 35 mg/dl She is considering a laparoscopic gastric bypass.

Clinical trial eligibility criteria: eligible ages (years): 30.0-999.0,  Obesity For in the study, patients must fulfill all of the following Subjects must be able to attend all 7 scheduled study visits at the West LA GI clinic at the not including the screening visit Subjects must sign the VA Greater Los Angeles Healthcare System Institutional Review Board approved written informed consent prior to the initiation of any study-related activities or study specific procedures or randomization Subjects must have given written authorization for the release of protected health information in compliance with Health Insurance Portability and Accountability Act (HIPAA) regulations. After the Informed Consent process, these additional will be applied to potential subjects Age 30 years and older at screening BMI of 27 to 40 kg/m2 inclusive Subjects must be in good health as determined by medical history, physical examination performed by the Investigator (Study doctor) at the Screening stage, and screening clinical laboratory tests including chemistry panel and CBC Must have stable smoking habits (or be non-smokers) for at least 6 months prior to screening and agree not to intend to change such habits during the course of the study Subjects requiring the regular use of any prescription medication may be admitted to the study, providing the dose is stable Subjects must be able to communicate and cooperate with the Principal Investigator and the staff and willing to comply with the study instructions  Weight instability: Subjects reporting weight change of greater than 3.0 kg in the month prior to screening Any subject who has been on a very low calorie diet (less than 800 kcal/day) for a period of 4 months or more in the 12 months prior to screening, or who has lost greater than 10 kg in the 6 months prior to screening Any subject who has a history of diabetic gastroparesis or gastric emptying disorder as indicated in the potential subject's medical history and VA's Computer Patient Record System (CPRS) Use of any other investigational drug(s) within 8 weeks prior to screening Subjects should not have received antibiotics within the prior 4 weeks of screening Abnormal laboratory parameters Serum creatinine greater than 1.6 mg/dL Liver function tests, alanine transaminase (ALT), alanine transaminase (AST), Bilirubin results greater than 2.0 times the upper limit of normal Triglycerides greater than 500 mg/dL Total cholesterol greater than 350 mg/dL