Patient description: A 46-year-old man presents with dizziness and frequent headaches. He has a family history of CAD, but no other cardiovascular risk factors such as smoking, high blood pressure, and diabetes mellitus and is physically active. The patient's LDL-C and HDL-C levels were 545 and 53 mg/dL, respectively. His fasting glucose and triglyceride levels (85 and 158 mg/dL, resp.) were within normal limits. The patient reported no use of lipid-lowering medications. Neck auscultation revealed a systolic murmur 3+/6+ in the neck, radiating to the skull. Ultrasonography of the carotid arteries, revealed severe stenosis in the left internal carotid artery (LICA), as well as moderate stenosis in the right internal carotid artery (RICA) estimated between 40% and 50%. For the LICA, the peak-systolic (PSV) and end-diastolic velocity (EDV) cutoff values were 208.5 cm/s and 54.5 cm/s, respectively; RICA PSV was 91.72 cm/s and RICA EDV was 37.37 cm/s. Plaque was observed in the anterior and posterior walls of the internal carotid artery and common carotid artery, which were characterized as bulky plates extending to the middle third of the internal coronary arteries (ICAs) and as predominantly echogenic and hyperechoic, with less than 50% of the area being echolucent with uneven surfaces.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Coronary Artery Disease The patient must be ≥18 years of age; 2. Patient is an acceptable candidate for PTCA, Stenting, or Emergent CABG; 3. Symptomatic ischemic heart disease (CCS class 1-4 , Braunwald class IB, IC, IIB, IIC,IIIB,IIIC) and/or objective evidence of myocardial ischemia; 4. TIMI (Thrombolysis In Myocardial Infarction) flow grade ≥ 2 ; 5. C.T.O's (Chronic Total Occlusions) and Bifurcation Lesions may also be attempted; 6. Target lesion stenosis is >50% and <100% ; 7. Target lesions are de novo; 8. Target lesions ≤ 35mm in length (by visual estimation) that can be treated (covered) by one single study stent (13 to 40mm in length) 9. Target lesion located in a major epicardial coronary vessel with reference of ≥ 2.5 - ≤ 3.5mm in diameter (by visual estimation) 10. Target lesions which can be covered by one stent, no overlapping allowed (lesion stent ratio of at least 1.5) 11. The patient and/or his legal representative has been informed of the nature of the study and agrees to its provisions and has provided a written informed consent  General Women of childbearing potential; 2. Impaired renal function (creatinine > 2.0 mg/dl or 180 μmol/l); 3. Any patient who has a platelet count < 100,000 cells/mm3 or > 700,000 cells/mm3, a WBC of < 3,000 cells/mm3, or documented or suspected liver disease (including laboratory evidence of Hepatitis; 4. Recipient of an organ (Heart, Kidney, Lung or Liver) transplant; 5. History of CVA or TIA within the last 3 months 6. Patient with a concomitant disease having a life expectancy of less than 12 months; 7. Known allergies or contraindication to mTOR inhibitor class of drugs (Sirolimus), Aspirin, Clopidogrel Bisulphate (Plavix®), Heparin, Cobalt Chromium/Nickel, contrast media; 8. Any significant medical condition which in the investigator's opinion may interfere with the patient's optimal participation in the study such as an active infection or peptic ulcer or upper GI bleeding; 9. Currently participating in an investigational drug or another device study, or subject to in another investigational drug or another device study during follow-up. 10. Clinically relevant contraindication to aspirin, heparin, clopidogrel bisulphate, including thrombocytopenia, neutropenia, or leukopenia 11. Patients with Cardiogenic Shock. Angiographic Left main coronary artery disease with ≥ 50% stenosis, 2. Angiographic evidence of thrombus (thrombus larger than half the diameter of the vessel and/or requiring other adjunctive interventions such as Angiojet, Exciser, Thrombolysis, etc.), 3. Left Ventricular Ejection Fraction ≤30 %, 4. Saphenous Vein Graft Interventions, (S.V.G's) 5. Patients presenting with an ongoing Acute Myocardial Infarction (AMI), 6. Patients having undergone a PCI within 48 hours of an AMI episode