Patient description: The patients is a 25-year-old G1 P1 pregnant woman who is 24W3D gestational old who developed a sudden unset of fever and chills, accompany with nausea and vomiting. She also complains of dysuria, urgency and frequency. She also reports some severe pain in the flank. Her vital signs are: T = 39.7ºC, P = 117, R = 20, and BP = 113/74 mm Hg. Physical examination reveals tenderness on palpation of both costovertebral angles. She has no history of recurrent UTI prior to her pregnancy or any other underlying disease. The urine culture showed Gram-negative rod-shaped bacterial cells, leukocytes, and leukocyte casts. The blood culture is negative. A CBC shows Hb 12.9 g/dL, Hct 39%, MCV 76 fL, WBC count 14,120/µL.

Clinical trial eligibility criteria: eligible ages (years): 18.0-90.0,  Bacteremia Bacterial Infection Require renal replacement therapy. 2. Be ≥ 18 years old and ≤ 90 years old 3. Positive blood culture and one of the following: 1. Clinical evidence of a catheter exit site to tunnel infection as evidenced by redness, tenderness or purulence. 2. Bacteremia is proven with two separate blood cultures from independent vein punctures. 3. A blood culture with Staphylococcus aureus where the time to positivity is within 14 hours. 4. Growth from a blood culture taken from the hemodialysis catheter 2 or more hours before the growth of a blood culture drawn peripherally at the same time  Have an arteriovenous polytetrafluoroethylene (PTFE) graft. 2. Lack of a commitment to full aggressive support. 3. Have inability to maintain a minimum mean arterial pressure of ≥ 65 mm Hg despite vasopressor therapy and fluid resuscitation. 4. Have had chest compressions as part of cardiopulmonary resuscitation (CPR) 5. Have had an acute myocardial infarction (MI) within the past 3 months. 6. Have had serious injury within 36 hours of screening. 7. Have uncontrolled hemorrhage. 8. Are not expected to live > 14 days. 9. Have malignancy and are not expected to live 42 days. 10. Have neutropenia (absolute neutrophil count <500 cells/µL). 11. Have Child-Pugh Class C cirrhosis. 12. Have New York Heart Association Class IV Heart Failure or an ejection fraction <30%. 13. Have known Antithrombin III deficiency. 14. Have platelet count <30,000/µL. 15. Cannot have intravenous (IV) supplemental iron halted during trial period. 16. Are currently involved in an investigational drug or device trial. 17. Have been previously enrolled in this clinical trial. 18. Next hemodialysis treatment will not take place for at least 24 hours after enrollment. 19. Serious bleedings and clotting disorders, determined by blood transfusion of > 2 units of packed red blood cells, or, An acute (48 h) hemoglobin decline of at least 2 g/dL, transfusion requirement of >4 units over 48h, objective evidence of bleed, documented by physician. 20. Breast feeding and pregnant women 21. Contraindications for heparin sodium for injection are: 1. Have heparin sensitivity 2. Severe thrombocytopenia. 3. With an uncontrolled active bleeding state, except when this is due to disseminated intravascular coagulation 4. In whom suitable blood coagulation tests, e.g. whole blood clotting time, partial thromboplastin time, etc cannot be performed at appropriate intervals (this contraindication refers to full-dose heparin; there is usually no need to monitor coagulation parameters in patients receiving low-dose heparin)