Patient description: A 53-year-old man presents with chronic HCV infection for the past 2 years. His past medical history is only significant for inguinal hernia surgery when he was 20 years old. He is on IFN (100 mg/week) plus RBV (400 mg/day) combination therapy for the past 9 months. Direct antiviral drugs were added to his treatment 6 months ago. His medical record shows previous positive HCV RNA tests as well as positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  HIV Infections HCV Age greater than or equal to 18 years. 2. Documentation of HIV-1 infection by licensed ELISA test and confirmed by a Western Blot. 3. Documentation of hepatitis C infection by demonstration of a positive test for hepatitis C antibody and HCV RNA level of 2000 copies/mL or greater. 4. Histopathologic features consistent with chronic hepatitis C at the time of enrollment. A liver biopsy done for a subject within 24 months prior to his or her participation may be used as the baseline biopsy. 5. Patients infected with genotype 1. 6. Patients with CD4+ cell counts greater than 100 cells/mm(3). 7. Ability to sign the Informed Consent document, and willingness to comply with the study requirements and clinic policies. 8. Neutrophil count greater than 1000 cells/mm(3). 9. Platelets greater than 75,000/mm(3). 10. Hemoglobin greater than 10.5 g/dL. 11. ALT less than 7 times the NIH upper limit of normal. 12. Serum lipase less than 1.5 times the NIH upper limit of normal. 13. Not pregnant or breast-feeding. 14. If the patient is able to become pregnant, then she must use two effective methods of contraception during the study. Effective contraceptive methods abstinence, surgical sterilization of either partner, barrier methods such as diaphragm, condom, cap, or sponge, or use of hormonal contraception with an anti-HIV regimen that will not alter metabolism of hormonal contraception. This is advised on the basis of using ribavirin, which may have a potential teratogenic effect on the fetus in pregnant women. 15. Willingness to not become pregnant until 7 months after completion of ribavirin therapy. 16. Male subjects who are not documented to be sterile agree to either abstain from intercourse or consistently and correctly use a condom while their female partner (if applicable) agrees to use one of the appropriate medically accepted methods of birth control listed above from the date of screening until 7 months after their last dose of ribavirin. 17. Patients with a documented addiction are currently in an addiction-free period for at least 6 months and in the clinical judgment of the investigator are not at risk of relapse. 18. Opioid-dependent patients are in a supervised methadone treatment program. 19. Need to have a primary doctor outside of OP8 or as part of the OP8 training clinic who will be taking care of the patients for their HIV infection and liver disease. 20. Willing to designate a person for durable power of attorney on the NIH form for medical research and medical care purposes at the NIH Clinical Center. 21. Able to learn to safely inject medication Alb-IFN subcutaneously or be able to find another person or a clinic to inject the medication for him/her. 22. Willingness to abstain from alcohol use during the trial. 23. Willingness to allow stored blood or tissue samples to be used in the future for studying HIV disease and immune function. 24. Willingness to permit HLA typing to be performed  Patient cannot be on other experimental therapies (including expanded access/compassionate use of antiretrovirals) during his/her participation in this protocol. 2. Patients cannot have used interferon or peginterferon previously for the treatment of hepatitis C. 3. Mixed genotypes (e.g., 1/2, 1/4). Mixed genotype 1a/1b will be enrolled. 4. Liver histology which, in the opinion of Clinical Center pathologist, is consistent with any other co-existent cause of chronic liver disease as defined as: chronic hepatitis B with positive HBsAg autoimmune hepatitis with a positive ANA greater than 1 unit or positive anti mitochondrial antibody greater than 1 unit; cholestatic disease with persistent elevation of alkaline phosphatase; primary biliary cirrhosis or sclerosing cholangitis; Wilson's disease; alpha-1-antitrypsin deficiency; steatohepatitis (alcoholic or non alcoholic) with marked steatosis, many Mallory bodies, or extensive zone 3 periportal fibrosis. 5. Hemochromatosis or secondary iron overload as defined by (1) an elevated serum ferritin or an iron saturation (serum iron/IBC times 100%) of greater than 50%, and (2) presence of 3+ or more stainable iron on liver biopsy according to the study pathologist. Those subjects with, or a history of previous phlebotomy for iron overload will undergo HFE genetic counseling and those with a positive HFE genetic test demonstrating homozygosity for C282Y and H63D are not eligible. Those who have compound heterozygosity to C282Y and H63D are also not eligible. 6. For patients with cirrhosis, a Child Turcotte Pugh score greater than 7. 7. PT-INR greater than 2 or history of hemophilia or known history of Vitamin K deficiency or use of anticoagulants. 8. Organ transplant recipient other than cornea or hair transplant. 9. Estimated Creatinine clearance (eGFR) less than 50 mL/min. 10. A serum alpha-fetoprotein level (greater than 20 ng/mL, unless the subject has a negative ultrasound before enrollment. 11. For patients with history of diabetes mellitus, a HbA1C less than or equal to 7.5% and for those with a fasting blood glucose level of greater than 140mg/dL, a HbA1C of less than or equal to 7.5%. 12. Coexisting neoplastic disease except for Kaposi's sarcoma, any non-metastatic skin cancer that has been resected, or non-metastatic cervical or anal cancer that has been resected. 13. Severe cardiac disease (Grade 3 or more congestive cardiac failure, symptomatic coronary artery disease, significant arrhythmias, uncontrolled hypertension). 14. Severe chronic pulmonary disease with functional impairment or a DLCO less than or equal to 50% at baseline. 15. Severe psychiatric disorder that would interfere with the adherence to protocol requirements. 16. Preexisting autoimmune disorders including inflammatory bowel diseases, psoriasis, and optic neuritis. 17. Preexisting uncontrolled seizure disorder defined as one episode of seizure within the past 2 years. 18. Chronic pancreatitis. 19. Severe retinopathy as determined by the ophthalmologist. 20. Hemoglobinopathy (e.g., Thalassemia, sickle cell disease). 21. Currently taking didanosine or d4T as part of antiretroviral regimen. 22. Direct bilirubin greater than or equal to 0.6 mg/dL. 23. Concurrent use of any immunosuppressive therapy, including systemic steroids (prednisone equivalent of greater than 10 mg/day) for a duration of six weeks or more within six months prior to enrollment. 24. Concurrent use of fluticasone and high dose ritonavir (600mg t.i.d). 25. Chronic viral hepatitis of any other etiology other than hepatitis C. 26. Active systemic infections other than hepatitis C and HIV. 27. Liver disease caused by reasons other than hepatitis C, like HBV, HDV, Wilson's disease, hemochromatosis, autoimmune hepatitis (ANA greater than 1 unit) except history of drug-associated hepatitis with discontinuation of the causative agent. 28. Hepatic mass suggestive of hepatocellular carcinoma as detected by ultrasound scan. 29. Alcohol or substance abuse within the past 6 months that potentially could interfere with patient compliance. 30. Concomitant use of amphetamines, barbiturates, cocaine, ganciclovir, isoniazid, opiates, pyrazinamide, rifabutin, rifampin/rifampicin, thalidomide, and theophylline. 31. History of esophageal varices. 32. Any systemic illness that will make it unlikely that the subject will be able to return to NIH for the required study visits. 33. Evidence of gastrointestinal malabsorption, chronic nausea, or vomiting. 34. Male partners of pregnant women. 35. Pregnant women. 36. Breastfeeding women. 37. Hypersensitivity to interferon products or ribavirin. 38. Received silymarin (milk thistle) or glycyrrhizin within 28 days prior to Day 0. 39. Received Sho-saiko-to (SST) within 28 days prior to Day 0. 40. Received any other experimental agent within 28 days prior to Day 0