Patient description: The patient is a 34-year-old obese woman who comes to the clinic with weight concerns. She is 165 cm tall, and her weight is 113 kg (BMI: 41.5). In the past, she unsuccessfully used antiobesity agents and appetite suppressants. She is complaining of sleep apnea, PCO and dissatisfaction with her body shape. She is a high-school teacher. She is married for 5 years. She doesn't use any contraceptive methods for the past 4 months and she had no prior pregnancies. She rarely exercises and movement seems to be hard for her. She is not able to complete the four-square step test in less than 15 seconds. She does not smoke or use any drugs. Her BP: 130/80, HR: 195/min and her BMI is: 41.54. Her lab results: FBS: 98 mg/dl TG: 150 mg/dl Cholesterol: 180 mg/dl LDL: 90 mg/dl HDL: 35 mg/dl She is considering a laparoscopic gastric bypass.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Obesity Nonsmoking men and postmenopausal women, ages 18 Premenopausal women who would not be expected to have significant fluctuations in estrogen and progesterone levels during the study (e.g. those on continuous monophasic hormonal contraception) may be included in the study at the discretion of the PI or designated study staff. 2. Body mass index (BMI) of at least 27 kg/m2 3. Body weight < 200 kg (the weight limit of the Bod Pod® scale) 4. Evidence of insulin resistance, as suggested by any one of the following Fasting glucose of 100 mg/dL or higher Impaired glucose tolerance, with a glucose concentration of 140 mg/dL or higher, 2 hours after a 75-gram oral glucose challenge A fasting insulin concentration of 9 mIU/L or higher 5. Willingness to consume only study food and drink for the duration of the study 6. Willingness to be randomized to any one of the three study diets 7. If applicable, willingness to maintain consistent intake of coffee and/or tea during the inpatient periods (due to the potential effects of these drinks on inflammatory markers) 8. Willingness to avoid the use of all over-the-counter or prescription vitamins, dietary supplements, and herbal products during the study. At the PI's discretion, other nutritional supplements, such as iron, may also be continued during the study if they are deemed medically necessary and are unlikely to influence study results. 9. If applicable, willingness to continue current antihypertensive medications (especially angiotensin converting enzyme inhibitors and angiotensin receptor blockers, which may affect levels of inflammatory markers) at the same dose and schedule throughout the study,unless a change is advised by the subject's primary care provider or the study investigators 10. Willingness to avoid the use of non-steroidal anti-inflammatory drugs (NSAIDS), including low-dose daily aspirin, throughout the inpatient admission, (due to the potential effects of these agents on inflammatory markers). 11. at least two of the following waist circumference greater than 35" in women or 40" in men blood pressure greater than 120/80 mmHg but less than 150/90 mmHg (on 2 blood pressure medications or less) triglyceride level greater than 150 but less than 500 mg/dL HDL ("good") cholesterol less than 40 mg/dL in men or 50 mg/dL in women  Current tobacco smoking 2. History of a bleeding disorder 3. Known or suspected cardiovascular disease, including angina, myocardial infarction, medical or surgical treatment for atherosclerotic disease, arrhythmia, or congestive heart failure 4. Blood pressure higher than 145/90 after 10 minutes of rest, confirmed on two or more visits, or treatment with three or more antihypertensive agents at any blood pressure. Subjects taking up to two antihypertensive agents may be included in the study if 1) BP is at least 115/75 mmHg but < 145/90 mmHg on these agents and 2) they agree to remain on the same medications (and same dosages) during the study, unless otherwise advised by a primary care provider or study investigators (e.g. the dosage may be reduced or the medication may be stopped if signs or symptoms of hypotension develop during the study) 5. Fasting glucose > 165 mg/dL, glycosylated hemoglobin > 8%, or any treatment with oral hypoglycemic agents, insulin sensitizing agents (e.g. metformin or thiazolidinediones), insulin, incretin mimetics (e.g. exenatide), amylin analogues (e.g. pramlintide), or endocannabinoid receptor antagonists (e.g. rimonabant). Volunteers with type 2 diabetes and a glycosylated hemoglobin level of 7.5% or higher will be encouraged to discuss treatment options (e.g. pharmacotherapy versus study participation) with their primary care providers before enrolling in the study 6. History of chronic glucocorticoid use, oral glucocorticoid use for more than 5 days in the previous year, or anticipated treatment with oral or intravenous glucocorticoids during the study period. Daily, low-dose, inhaled or nasal glucocorticoids may be acceptable in some cases, at the discretion of the Principal Investigator. 7. Current treatment with over-the-counter or prescription weight loss medications, such as orlistat or sibutramine 8. History of bariatric surgery 9. Current treatment with any cholesterol-lowering medications, such as statins, niacin,fibrates, or ezetimibe 10. Hyperthyroidism or untreated hypothyroidism. Subjects with chronic, treated, stable hypothyroidism may be included in the study at the discretion of the Principal Investigator 11. Obstructive sleep apnea, or significant symptoms suggestive of this condition 12. Active gallstone disease 13. Known history of chronic hepatitis, or liver enzymes (AST or ALT) more than 2.5 times the upper limit of normal 14. Known infection with HIV or confirmed positive test for HIV antibody 15. Inflammatory bowel disease, active cancer, or any other medical condition that may cause significant acute weight loss or gain 16. Sustained weight loss > 5% of body weight in the previous two months, or sustained weight loss > 10% of body weight in the previous six months 17. History of kidney stones 18. Chronic or acute renal disease 19. Serum calcium, potassium, or magnesium above the normal limit, confirmed on two screening tests 20. Seizure disorder 21. History of any inpatient psychiatric admission within the past two years 22. History of schizophrenia, psychosis, or bipolar disorder 23. History of anorexia nervosa or bulimia nervosa, as defined in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), or a history of medical or psychological treatment for an eating disorder 24. Severe binge eating disorder, as defined as a Binge Eating Scale score of 27 or more. Individuals with scores of 18-26, which may be indicative of moderate eating disturbances, will be evaluated further to determine whether moderate to severe eating pathology actually exists. This evaluation process will be based on the DSMIVresearch for binge eating disorder. Individuals with scores of 18-26 who meet the DSM-IV research for binge eating disorder will be excluded, whereas those without significant eating pathology may be included in the study. 25. Untreated moderate to severe depression, as evidenced by a Beck Depression Inventory score of 20 or higher at screening. Subjects with a remote history of depression or stable, treated depression may be included in the study at the discretion of the Principal Investigator 26. History of alcohol or drug abuse within the previous two years 27. History, physical, or laboratory findings suggestive of any other medical or psychological condition that would, in the opinion of the principal investigator, make the candidate ineligible for the study. 28. Any social or behavioral condition that, in the opinion of the investigator, would interfere with adherence to study requirements