Patient description: The patient is a 55 year old man visiting his primary care physician for lower urinary tract symptoms including frequency, urgency, weak stream, incomplete emptying and intermittent flow for the past 9 months. Further evaluation revealed: IPSS score : 15 Post-void residual: 70 mL Prostate volume (TRUS): 60 mL Prostate-specific antigen (PSA) level: 3.2 ng/mL 10 mL/sec of maximum flow rate when urine volume was 130 mL He is otherwise healthy only using Vit D 1000 units daily. His recent blood chemistry (3 days ago) was normal: Hgb: 13.5 g/dl WBC: 135000 /mm3 Plt: 350000 /ml PT: 11 second PTT: 35 second INR: 0.9 Creatinine: 0.5 mg/dl BUN: 10 mg/dl U/A: Color: yellow Appearance: cloudy PH: 5.3 Specific gravity: 1.010 Glc: 100 Nitrite: negative Ketone: none Leukocyte esterase: negative RBC: negative WBC: 2 WBCs/hpf U/C: negative

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Left-Sided Ulcerative Colitis Proctosigmoiditis Outpatient males and females between 18 and 75 years. 2. Females of child bearing potential must have a negative serum pregnancy test (beta-human chorionic gonadotropin) at screening and must be sexually inactive (abstinent) for 3 months prior to dosing and throughout the study or be using one of the following acceptable methods of contraception barrier methods (condom, diaphragm with spermicide) Intrauterine device (IUD) in place for at least 3 months surgical sterilization of the partner (vasectomy for at least 6 months); or hormonal contraceptives for at least 3 months prior to dosing. [Female subjects of childbearing potential must be advised to remain sexually inactive or maintain the same method of contraception for ≥7 days following the end of dosing of study treatment] 3. Patients newly diagnosed or with ongoing active distal ulcerative colitis of >3 months duration, confirmed by flexible sigmoidoscopy during screening, and extending 5 to 50 cm from the anal margin. Sigmoidoscopy must be conducted within not more than 3 +/ days before the Baseline (Day 0) Visit. 4. Patients with ongoing active distal ulcerative colitis of ≥3 months duration must be on a stable dose of oral mesalamine (5-ASA) for ≥2 months before the Baseline (Day 0) Visit. 5. Modified Mayo Score (Disease Activity Index) of ≥5 to ≤10 at Baseline, including a sigmoidoscopic inflammation grade score of ≥2 and a rectal bleeding score ≥2. 6. Negative stool test at screening to rule out parasites, bacterial pathogens and Clostridium difficile. 7. Able and willing to fill in (maintain) daily diary cards from Day -7 to Day 21 of the study. 8. Able to provide voluntary written informed consent prior to initiation of screening, must be capable of following the verbal and written study instructions, and be able to commit to the return visits during the entire period of the study  History or presence of clinically significant cardiovascular, pulmonary, hepatic, renal, hematological, gastrointestinal, endocrine, immunologic, dermatological, neurological, or psychiatric disease, that could compromise patient's ability to participate in the study, and/or interfere with absorption of the study drug or the interpretation of the study data. 2. Patients with a diagnosis of Crohn's disease. 3. Patients with a modified Mayo score of ≥11 at the Screening (Day -7 & Day -3) Visits. 4. Patients at immediate or significant risk of toxic megacolon; those with bowel stricture, colonic dysplasia, adenoma or carcinoma. 5. Use of botanical treatments and supplements for ulcerative colitis within 14 days prior to the Baseline Visit. 6. Patients with any enteric pathogens, ova or parasites, or Clostridium difficile toxin in stool. 7. Female patients with a positive pregnancy test or lactating at the Screening/Baseline Visits. 8. History of allergic reaction or hypersensitivity to spinach, spinach tablet, spinach powder or spinach extract; and to latex, molds and mushrooms. 9. History of gout, pseudogout or hyperuricemia, or kidney stones. 10. History of pseudoallergic hypersensitivity to the food color additives, tartrazine (E102), sunset yellow (E110) and FD & C Blue No.1 (Brilliant blue FCF; E133), allergic asthma, aspirin intolerance, and severe or multiple allergies. 11. Past medical history of significant gastrointestinal surgery including but not limited to colostomy, ileostomy, or previous colonic surgery other than appendectomy. 12. Patients with anatomical abnormalities of the colon, e.g., short bowel or other abnormalities. 13. Patients with any current infectious, ischemic, or immunologic disease with gastrointestinal involvement. 14. Patients with a history of failure to retain enemas. 15. Use of antibiotics for reasons related to the primary diagnosis or for other gastrointestinal-related conditions within 14 days of Baseline Visit. 16. Patients who used non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, within 14 days prior to Baseline Visit. Except aspirin ≤325 mg/day for cardiovascular prophylaxis. 17. Patients who used the following medications used for treating ulcerative colitis from the times indicated below to the end of Week 3 (Visit 6) Topical intrarectal corticosteroids or topical intrarectal mesalamine within 14 days of Baseline Visit Systemic corticosteroids (oral or injectable, including adrenocorticotropic hormone [ACTH]) within 30 days of Baseline Visit Immunosuppressant therapy (methotrexate, azathioprine, 6-mercatopurine or cyclosporine) within 60 days of Baseline Visit; and Biologic therapy (tumor necrosis factor-α inhibitors, monoclonal antibodies, etc.) within 90 days of Baseline Visit. 18. Patients with a history of active malignancy within the past 5 years except for squamous cell or basal cell cancers of the skin. 19. History of any clinical laboratory abnormality deemed significant by the Principal Investigator. 20. History of significant alcohol or drug abuse within one year prior to the Screening Visit. 21. Patients who tested positive at Screening for human immunodeficiency virus (HIV), hepatitis B surface antigen (HbsAg) or hepatitis C virus (HCV). 22. Exposure to any investigational or non-registered drug within 30 days prior to administration of study drug