Patient description: A 3-day-old Asian female infant presents with jaundice that started a day ago. She was born at 38w3d of gestation, after an uncomplicated pregnancy. The family history is unremarkable. The baby is breastfed. Vital signs are reported as: axillary temperature: 36.3°C, heart rate: 154 beats/min, respiratory rate: 37 breaths/min, and blood pressure: 65/33 mm Hg. Her weight is 3.2 kg, length is 53 cm, and head circumference 36 cm. Her sclera are yellow and her body is icteric. No murmurs or any other abnormalities are detected in the heart and lung auscultation. Her liver and spleen are normal on palpation. Laboratory results are as follows: Serum total bilirubin: 21.02 mg/dL Direct bilirubin of 2.04 mg/dL AST: 37 U/L ALT: 20 U/L GGT: 745 U/L Alkaline phosphatase: 531 U/L Creatinine: 0.3 mg/dL Urea: 29 mg/dL Na: 147 mEq/L K: 4.5 mEq/L CRP: 3 mg/L Complete blood cell count within the normal range. She is diagnosed with uncomplicated neonatal jaundice that may require phototherapy.

Clinical trial eligibility criteria: eligible ages (years): 12.0-17.0,  Non-Alcoholic Fatty Liver Disease NAFLD Pediatric NAFLD For clinical referral to screening visit: 1. Age: 12 to <20 years old 2. Diagnosis of Obesity: BMI-percentile ≥95th (using age and sex based Center for Disease Control definitions) or BMI ≥30 kg/m2 3. Elevated alanine aminotransferase (ALT) more than twice the upper limit of normal by gender (≥44 U/L for girls, ≥50 U/L for boys) within 3 months prior to screening (used for historic ALT value) OR diagnosis of NAFLD from ultrasound, MRI, or participants with biopsy-proven NASH within 12 moths of screening 4. History of lifestyle modification to treat obesity or NAFLD To be obtained at screening visit: 1. Confirmation of Obesity 2. Tanner stage 2 3. Normal fasting glucose tolerance (fasting blood glucose <100 mg/dL) 4. If Screening ALT is used as [if > 2x historic ALT value (historical value obtained clinically within 12 months of screening visit), repeated after 4 weeks [unable to randomize until completed]]. If the repeat ALT is more than 50% increased or decreased over the screening ALT, a third ALT should be obtained. If a third ALT is not within 50% of the previous value, then the subject is ineligible but may be screened at a later date. If ALT is not used An ultrasound will be done to diagnose NAFLD if the diagnosis has not previously been made by ultrasound, MRI or biopsy A MRI-derived HFF ≥ 5.5% 5. Willingness to adhere to lifestyle considerations throughout the study  ALT > 250U/L at screening 2. History of significant alcohol intake or current use 3. Impaired fasting glucose (>100 mg/dL) 4. Diabetes (type 1 or 2) 5. Current or recent (<6 months prior to enrollment) use of weight loss medication(s) 6. Vitamin E supplementation 7. Previous bariatric surgery 8. Use of metformin 9. Prior use of empagliflozin 10. Lower limb infection/ulceration within 3 months of screening 11. Metal or magnetic implants, devices or objects inside of or on the body, which are not MRI compatible 12. Structural and functional urogenital abnormalities, that predispose for urogenital infections 13. Recent initiation (<3 months prior to enrollment) of anti-hypertensive or lipid medication(s) 14. Major psychiatric disorder 15. Current pregnancy or plans to become pregnant.Females unwilling to be tested for pregnancy. Females will be tested for pregnancy. Females who are sexually active and not protected by an effective method of birth control (e.g. UID or medication or patch) 16. Tobacco use 17. Significant liver dysfunction (levels >5 times the upper limit of normal (ULN)): ALT (ULN = 50 U/L) AST (ULN = 48 U/L) GGT (ULN = 48 U/L) ALP (ULN = 115 U/L) 18. Platelets < 150,000 cells/mm3 19. Total bilirubin 1.3 mg/dL 20. INR 1.3 21. Albumin <3.2 g/dL 22. Gilbert's Syndrome 23. Any known causes of liver disease (except NAFLD and NASH) 24. Significant renal dysfunction (estimated glomerular filtration rate [eGFR] < 90 mL/min/1.73 m2), 25. Diagnosed monogenic obesity 26. History of cancer 27. Untreated thyroid disorder 28. History of decompensation events (ascites, variceal bleeding, hepatic encephalopathy, or hepatocellular carcinoma) 29. Current or recent (<6 months prior to enrollment) use of medication(s) associated with weight gain (e.g. atypical anti-psychotics)