Patient description: The patient is a 34-year-old African American man with the known history of Sickle cell disease comes to the clinic with severe bone pain. The patient had severe pain in his lower back that radiated to both thighs scored 9 out of 10. The patient has had positive history of sickle cell crises since childhood. He also had the same symptoms in past two weeks treated with oxycodone which was not beneficial to his pain. His PCP sent him to the emergency department to receive intra venous pain modulators. The patient is afebrile within the normal blood pressure. No splenomegaly was detected in the physical exam. He has no positive history of drug allergy. He won't smoke or uses any illicit drugs. The lab study is as bellow: Hgb: 8 g/dl WBC: 10000 /mm3 Plt: 300000 /ml MCV: 106 fL Hemoglobine electrophoresis: 91% HbS 6%HbF 3%HbA2 AST: 22 U/L ALT: 43 U/L Alk P: 53 U/L Ferritin: 1200 ng/ml

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Non-Small Cell Lung Cancer Brain Metastasis Histological or cytological documented stage IV NSCLC. Sputum cytology alone is excluded 2. Extracerebral lesions show stable disease after first line chemotherapy. Patient has recovered from CTCAE grade 3/4 toxicity. Patients who had never received EGFR-TKI or EGFR monoclonal antibody. 3. Patients must be at least 18 years. 4. ECOG Performance Status 0, 1 or 2. 5. Life expectancy of at least 12 weeks. 6. Appraisable disease, the presence of at least three lesions if longest diameter <10 mm by brain MRI. 7. Haemoglobin ³ 10.0 g/dl, Absolute neutrophil count (ANC) ³1.5 x 109/L, platelets ³ 100 x 109/L. 8. Total bilirubin £ 1.5 x upper limit of normal (ULN) 9. ALT and AST < 2.5 x ULN in the absence of liver metastases, or < 5 x ULN in case of liver metastases. 10. Creatinine clearance ³ 60ml/min (calculated according to Cockcroft-gault formula).11. PT-INR/PTT < 1.2 x ULN. 12. Written informed consent.13. Able to comply with study and follow-up procedures  Mixed small cell and non-small cell lung cancer histology. 2. Any unresolved toxicity>CTCAE grade 2 from previous anti-cancer therapy. 3. Patients with exposure to biotherapy, immunotherapy within 4 weeks of study entry. 4. Other concurrent anticancer therapy. 5. Patients with exposure to investigational drug therapy outside of this trial. 6. Lack of physical integrity of the upper gastrointestinal tract, or malabsorption syndrome, or inability to take oral medication, or have active peptic ulcer disease. 7. Any unstable systemic disease (including active infection, hepatic, renal, metabolic disease or seizure disorder requiring medication). 8. Significant cardiovascular event: congestive heart failure >NYHA class 2; unstable angina, active CAD (myocardial infarction more than 1 year prior to study entry is allowed); serious cardiac arrhythmia requiring anti-arrhythmic therapy ( beta blockers or digoxin are permitted) or uncontrolled hypertension. 9. Brain metastases or spinal cord compression, if treated before the start of study treatment, and have any symptoms. Symptoms signs of increased intracranial pressure ,headache,nausea and vomiting,cognitive or affective disturbances,seizures,and focal neurologic symptoms. 10. History of another malignancy within the last 5 years except cured carcinoma in-situ of uterine cervix, cured basal cell carcinoma of skin and superficial bladder tumors [Ta, Tis & T1]. 11. Pregnant or breast-feeding women. 12. Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results. 13. Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study