Patient description: A 54-year-old obese woman admitted to the emergency department with abdominal pain that started 4 days ago with nausea and vomiting. The epigastric pain radiates to the right upper quadrant, getting worse after eating fatty food. The patient experienced similar pain twice in the past year. Her past medical history is remarkable for hypercholesterolemia and 2 NVDs. She has 2 children, and she is menopausal. She does not smoke, drink alcohol, or use illicit drugs. She is mildly febrile. Her BP is 150/85, HR 115, RR 15, T 38.2, SpO2 98% on RA. She is an obese woman with no acute distress. On palpation, she experiences epigastric tenderness and tenderness in the right upper quadrant without rebound. Bowel sounds are normal. Laboratory analysis is remarkable for elevated ESR and leukocytosis with a left shift. The ultrasound revealed several gallstones, biliary sludge and CBD stones. The smallest stone is 14mm.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Biliary Stricture Biliary Anastomotic Stenosis Biliary Obstruction Biliary Disease Age ≥ 18 and ≤ 80 years. 2. Benign biliary stricture with postoperative injury or PSC or anastomotic-stricture; and indicated for ERCP procedure. 3. Restenosis after plain balloon dilation with at least 2 previous balloon dilation sessions and recurrence of biliary obstructive symptoms/signs or being managed with implantable prosthetics (e.g. plastic stents). 4. Greater than 40% stenosis of the biliary tract via ERCP. 5. Total serum bilirubin >2 mg/dL. Alkaline phosphatase level >3 times higher than normal level. *Note: This IC is waved if the patient is being managed with implantable prosthetics. 6. Type I, II, III and IV Benign biliary duct strictures. Dominant stricture being accessible by balloon catheter. 7. Stricture length <4 cm. 8. Not currently listed for liver transplantation. 9. Voluntary participation and provided written informed consent  Pregnancy or breastfeeding or plan to get pregnant in next 12 months. 2. Benign biliary strictures caused by pancreatic pseudocyst compression. 3. Malignant biliary obstruction. 4. Biliary obstruction associated with an attack of acute pancreatitis. 5. Inability to pass guidewire across stricture. 6. Subjects with cholangitis or bile leak or duct fistula. 7. Contraindication for Endoscopic Retrograde Cholangiopancreatography (ERCP) or anesthesia or deep sedation or MRI. 8. Subject with an internal/external biliary drainage catheter. 9. Subjects with surgically altered gastro/duodenal/jejunal anatomy (e.g. Roux-Y-loop, choledochojejunostomy). 10. Subject with symptomatic duodenal stenosis (with gastric stasis) 11. Active systemic infection. 12. Allergy to paclitaxel or any components of the delivery system. 13. Currently undergoing required thoracic or abdominal cavity radiation therapy. 14. Has life expectancy <12 months. 15. Unwilling or unable to comply with the follow-up study requirements. 16. Lacking capacity to provide informed consent. 17. Concurrent medical condition that would affect the investigator's ability to evaluate the patient's condition or could compromise patient safety. 18. Currently participation in another pre-market drug or medical device clinical study