Patient description: The patient is a 47-year-old Asian woman complaining of persistent feelings of sadness. She lost interest in activities she used to enjoy. She states that her mood is mostly depressed for the past 3 weeks. She also lost her appetite , which led to about 5kg weight loss. She complains of loss of energy and feelings of worthlessness nearly every day. She is not using any drugs and she does not smoke. She doesn't drink alcohol. She used to exercise every day for at least 30 min. But she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was recently diagnosed with colon cancer and he is starting his chemotherapy. There is nothing remarkable in her past medical history and her drug history is only positive for Vit D3 1000 units daily. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Sleep Troubles Associated With Anxiety Woman or man, aged of 18 to 65 years In good general health as evidenced by medical history and physical examination Having at least 3 episodes of sleep disorders per week including one or more of the following: 1. difficulty falling asleep or 2. difficulty staying asleep or 3. poor quality sleep 4. Waking up earlier than desired The insufficient sleep duration and quality is coupled with a feeling of general fatigue Sleep disorder last for more than 1 month Presenting moderate to severe sleep disorder in the past month (ISI ≥ 15) With anxiety resulting in a HAM-A score > 8 and < 25 For women of childbearing age (women of childbearing potential, pre-menopausal or having postmenopausal amenorrhea of less than 12 months, and women who have not undergone surgical sterilization): 1. Negative blood pregnancy test 2. Acceptance to use an effective method of contraception, established for at least 1 month, and throughout the duration of the study Fluent French speaking Provision of signed and dated informed consent form  A score > 10 on the ESS scale (that would correspond to serious hypersomnia) Sleep disorders secondary to another health problem (sleep apnea syndrome, narcolepsy-cataplexy, idiopathic hypersomnia, restless legs syndrome, chronic pain syndrome, ...) or an environmental factor (noise, light ...) or socio-professional (shift work, young child at home, people who are often jet lagged,… ) Severe psychiatric disorder or disease within 6 months before (depression, bipolar disorder, severe anxiety, psychosis, schizophrenic disorders, dementia,…) or a severe neurologic trouble (Alzheimer's, autism, Parkinson's disease, …) Subjects presenting severe gastro-intestinal, hepatic, respiratory, kidney or cardiovascular disorder or severe infection (e.g. HIV, hepatitis, …) Acute or chronic somatic pathologies which can interfere with sleep: kidney cancer, etc Subjects with pre-menstrual syndrome or myasthenia gravis Subjects who drink more than 2 glasses of alcohol per day (> 20g of alcohol per day) or with exaggerated consumption of theine (≥ 1l per day) and caffeine-rich (≥ 800ml per day) beverages and energy drink (≥ 330ml per day) Smoker Subject consuming drugs and/or with historical drug addiction Under psychotropic treatment within the last month before screening (neuroleptic, anxiolytic, antidepressant, hypnotic, sedative, …) or under current medication treatment which may alter the waking state (for example: cortisone, dopamine, amphetamine, antihistamines, beta-blockers, certain cough syrups, .…)