Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 21.0-60.0,  Alcoholism fMRI Rewarding Mediating System (Light Drinkers): 1. In good health as determined by medical history, physical exam, ECG, and lab tests; 2. Between 21 and 60 years of age; 3. Currently consuming on average 1-10 drinks per week for females and on average 1-14 drinks per week for males, (averaging over the 90 days recorded in the Alcohol Timeline Followback); 4. Right handed  (Light Drinkers): 1. Have liver function tests (AST, ALT, GGT, ALP) 3-times the upper limit of normal (ULN); or have Total Bilirubin above 1.5 ULN and Albumin below 3.5 g/dl; 2. Have fulfilled DSM-IV-TR or DSM-5 for alcohol dependence or alcohol use disorder (past or current) at any time, or other current substance dependence or substance use disorder (excluding nicotine); 3. Report having received any medication to treat a psychiatric disorder within the past year, have a past or present diagnosis of a psychotic or bipolar disorder, or have ever had a head injury requiring hospitalization; 4. Weigh over 330 pounds; 5. Are pregnant, as determined by a positive pregnancy test, or breast feeding; Report to have a facial, body, and limb flushing response to the consumption of alcohol, as determined by the Alcohol Flushing Questionnaire; 6. Report to have a "facial flushing" response to the consumption of alcohol 7. Have ferromagnetic objects in their bodies which might be adversely affected by MRI including implanted pacemakers, medication pumps, aneurysm clips; metallic prostheses (including metal pins and rods, heart valves or cochlear implants, shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal works may have any doubt about presence of these objects will result in from this study), or if candidates are uncomfortable in small closed spaces (have claustrophobia), or cannot lie comfortably on their back for up to one hour; 8. Medical illnesses (such as diabetes or stage 2 hypertension systolic blood pressure greater than or equal to 160 mm Hg or diastolic blood pressure greater than or equal to 100 mm Hg) or neurological illnesses (carpal tunnel syndrome; migraine headaches; seizure disorders) likely to interfere with the study; 9. Endorse more than 3 symptoms on the Yale Food Addiction Scale; 10. Have colorblindness. (Heavy Drinkers): 1. In good health as determined by medical history, physical exam, ECG, and lab tests; 2. Between 21 and 60 years of age; 3. Currently consuming on average 15+ drinks per week for females and on average 20+ drinks per week for males, as determined by the 90-day Alcohol Timeline Followback, or fulfilled DSM-IV-TR for current alcohol dependence or DSM-5 for current alcohol use disorder; 4. Right-handed; 5. Clinical Institute Withdrawal Assessment Alcohol Revised (CIWA-AR) score less than 8; 6. Not seeking treatment for their alcohol consumption (Heavy Drinkers): All for Light Drinkers except for Light Drinker criterion number two. For Heavy Drinkers this criterion will read: Have fulfilled DSM-IV-TR or DSM-5 for any current substance dependence or current substance use disorder (excluding alcohol or nicotine)