Patient description: The patient is a 47-year-old Asian woman complaining of persistent feelings of sadness. She lost interest in activities she used to enjoy. She states that her mood is mostly depressed for the past 3 weeks. She also lost her appetite , which led to about 5kg weight loss. She complains of loss of energy and feelings of worthlessness nearly every day. She is not using any drugs and she does not smoke. She doesn't drink alcohol. She used to exercise every day for at least 30 min. But she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was recently diagnosed with colon cancer and he is starting his chemotherapy. There is nothing remarkable in her past medical history and her drug history is only positive for Vit D3 1000 units daily. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Depressive Disorder Pregnancy Group 1 (Observational, not-randomized) 1. Planning pregnancy or pregnant < 28 weeks gestation 2. Currently meet for stable remission from MDD, defined as a baseline score of < 10 on the Montgomery-Åsberg Depression Rating Scale (MADRS) 3. Current or recent treatment with an AD 4. Have elected to discontinue AD medication for pregnancy (may have already begun or completed taper) 5. Have a history of a major depressive episode/ Previous Episode of MDD, as verified using the MINI Structured Clinical Interview for DSM-5; have MDD as one of their primary diagnoses 6. Has a treating prescribing clinician for the treatment of MDD  Current major depressive episode, as diagnosed on the MINI mood portion 2. Significant risk for self-harm or harm to others 3. Psychotic symptoms 4. Meeting for a primary diagnosis of schizophrenia, an active eating disorder, dementia, delirium, or other cognitive disorder 5. Presence of an active substance and/or alcohol abuse disorder within six months prior to screening 6. Pernicious anemia or history of gastric bypass surgery 7. Seizure disorder and/or on anticonvulsant medications 8. Allergy to beeswax, soy, fish, nuts, peanuts, egg, wheat, milk, and/or shellfish 9. Non-English speaking Group 2 1. Planning pregnancy or pregnant < 28 weeks gestation 2. Currently experiencing clinically significant depressive symptoms, defined as a baseline score of > 15 on the Montgomery-Åsberg Depression Rating Scale (MADRS) 3. Experiencing a major depressive episode, as verified using the MINI Structured Clinical Interview for DSM-5; have MDD as one of their primary diagnoses 4. Has a treating prescribing clinician for the treatment of MDD Significant risk for self-harm or harm to others 2. Psychotic symptoms 3. Meeting for a primary diagnosis of schizophrenia, an active eating disorder, dementia, delirium, or other cognitive disorder 4. Presence of an active substance and/or alcohol abuse disorder within six months prior to screening 5. Pernicious anemia or history of gastric bypass surgery 6. Seizure disorder and/or on anticonvulsant medications 7. Allergy to beeswax, soy, fish, nuts, peanuts, egg, wheat, milk, and/or shellfish 8. Non-English speaking