semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 19.0-85.0,  Movement Disorders (Incl Parkinsonism) Tremor Familial Essential, 1 REM Sleep Behavior Disorder Healthy Control • Age 35-85 Parkinson Disease (PD) Age 35-85 Diagnosis of clinically definite PD made by a movement disorders specialist, with evidence of the following features Presence of bradykinesia and 1 or both of the following: 1. Rest tremor 2. Rigidity Asymmetric Onset Progressive motor symptoms Levodopa responsive Duration at least 1 but not more than 10 years Hoehn and Yahr Stage 1-2 Progressive Supranuclear Palsy (PSP) Age 40-85 Diagnosis of clinically definite PSP, with the following features Gradually progressive disorder Onset after age 39 Supranuclear palsy* and postural instability with falls in the first year of disease onset*  Healthy Control Pregnancy First-degree blood relative affected by PD Neurodegenerative disease History of repeated head injury, encephalitis, brain surgery, stroke, dementia, neuroleptic exposure, or serious medical illness that may interfere with participation. Parkinson Disease (PD) Any that would a healthy control patient Atypical features indicative of a Parkinson-Plus disorder Progressive Supranuclear Palsy (PSP) Any that would a healthy control patient
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 17.0-80.0,  Small Bowel Crohn's Disease patients with known SBCD or newly diagnosed SBCD those patients for whom complete CE examination (in which the capsule reached the cecum within the CE test time) was achieved were retained for study  incomplete CE examination infectious enterocolitis symptoms related to perianal penetrating disease gastrointestinal cancer ulcerative colitis indeterminate colitis history of extensive small bowel resection known CD of the upper gastrointestinal tract or colon intake of non-steroidal anti-inflammatory drugs (NSAIDs) (more than two tablets per week) pregnancy
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 20.0-70.0,  Hepatitis C Virus Infection, Response to Therapy of Patients with Chronic Hepatitis C Infection Receiving Interferon Therapy Aged above 18  None
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Multiple Myeloma For the first part of the study  adult patient giving a free, informed and written consent patient having a follow-up in the service for multiple myeloma, whatever the age of diagnosis, the isotype of monoclonal component, stage and disease activity patient hospitalized in the service whatever the reason for hospitalization (related or not with multiple myeloma) proteinuria ≥ 500 mg/24h percentage of albuminuria < 50% on urinary protein electrophoresis presence of immunoglobulin FLC in immunofixation of urine proteins For the second part of the study  adult patient  minor patient proteinuria < 500 mg/24h predominantly glomerular proteinuria with ≥ 50% albumin on urinary protein electrophoresis absence of immunoglobulin FLC in urine proteins immunofixation progressive urinary infection patient with a glomerular nephropathy macroscopic hematuria patient unable to perform a urinary collection for 24 hours patient unable to give a consent pregnant or lactating woman
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-50.0,  Essential Tremor Age ≥ 18 years and < 50 years Important essential tremor (bilateral postural and/or action tremor since more than one year) Normal physical and neurological examination, except for essential tremor Insufficient efficiency of usual essential tremor's treatment No treatment altering the cortical excitability Agreement to use a medically acceptable method of contraception throughout the study for female of childbearing potential  Cervical tremor Current neurological or psychiatric illness other than essential tremor Individual who is on medication which is known to lower seizure threshold Previous history of seizure(s), malaise or current active epilepsy Contraindication for MRI or TMS study Pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide an informed consent Simultaneous participation in another clinical trial Patients who are not enrolled at social security
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 2.0-15.0,  Spinal Muscular Atrophy Children aged 2-15 years having motor weakness, hypotonia and hyporeflexia with onset noticed after 6 months of age Presence of exon7 deletion of SMNT gene. OR Normal/ mildly elevated CPK with electrodiagnostic characteristics suggestive of neurogenic weakness, normal motor and sensory nerve conduction velocities and muscle biopsy showing neurogenic atrophy and /or evidence of reinnervation  SMA type I, onset before 6 months of age. 2. Severely ill and unstable patients requiring life support system. 3. Other causes like cerebral palsy, Down syndrome, connective tissue disorders, metabolic disorders. 4. Pre-existing liver damage, bone marrow depression and coagulation disorders. 5. Use of medications or supplements which interfere with valproic acid and carnitine metabolism within 3 months of study enrollment. 6. Current use of either valproate or levocarnitine. If study subject is taking valproate and carnitine then patient must go through a washout period of 12 weeks before enrollment into the study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Alcoholic Liver Diseases Decompensated Cirrhosis Male or female patients 18-75 years of age Diagnosis of cirrhosis based upon a) Histological confirmation b) Combination of clinical and radiological c) Validated non invasive biomarker Alcohol as the primary aetiology for liver cirrhosis Hospital admission related to decompensated liver disease (e.g. ascites, varices, sepsis, alcoholic hepatitis) Active alcohol drinking prior to index hospital admission  Grade 3 or 4 hepatic encephalopathy Hepatocellular carcinoma Active non hepatic malignancy Known complete portal vein thrombosis Alcohol abstinence at time of index hospital admission Pregnancy Active cardiac devices (e.g. cardiac pacemaker, implantable cardioverter defibrillator)
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Chronic Hepatitis C Documented chronic genotype 1a or genotype 1b hepatitis C virus (HCV) infection with HCV ribonucleic acid (RNA) level >100,000 IU/mL at screening Treatment-naive or documented prior relapser to previous treatment regimens and has stopped treatment at least 3 months before screening Liver biopsy within 3 years before the screening visit or elastography results available prior to first study drug dosing Medically stable based on physical examination, medical history, vital signs, and electrocardiogram performed at screening Body mass index of 18.0 to 32.0 kg/m2 and body weight more than 50 kg  Evidence of liver cirrhosis by liver biopsy or the presence of esophageal varices or a transient elastography result of >14.6 kPa within 2 years prior to first dosing Evidence of decompensated liver disease defined as prior history or current evidence of ascites, hepatic encephalopathy, bleeding oesophageal or gastric varices Evidence of any significant liver disease in addition to hepatitis C (including but not limited to hepatitis B, drug or alcohol-related cirrhosis, autoimmune hepatitis, hemochromatosis, Wilson's disease, non-alcoholic steatohepatitis, or primary biliary cirrhosis) Receiving or has received any HCV-specific direct antiviral agent (HCV protease inhibitors, HCV nucleoside polymerase inhibitors, HCV non-nucleoside polymerase inhibitors, HCV NS5a inhibitors or any other HCV inhibitor targeting an HCV protein or a target involved in the HCV replication cycle Co-infected with human immunovirus (HIV)-1 or HIV-2, with non-genotype 1a/1b HCV, or hepatitis A or B virus infection
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 20.0-80.0,  Tremor Age: 20-80 years Patients with tremor (involuntary, rhythmic, oscillatory movement in one or more body part) Subject who signed an informed consent  Pregnant or nursing woman Comorbid neurologic illnesses that impact the ability to perform the study tasks Subjects with medical condition that in the opinion of the investigator would affect his/her ability to participate in this study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Tremor Essential Tremor Parkinson Disease Radiosurgery Quality of Life Must be certified by a neurologist as having essential tremor or Parkinsonian tremor that is insufficiently controlled by medication alone Preference to receive radiation treatment for tremor treatment, rather than surgical DBS implantation or surgical thalamotomy At least 18 years old  Contraindications to cranial radiation (such as prior radiation to the thalamus) Inability to have a MRI of the brain Prior surgical thalamotomy treatment (but contralateral deep brain stimulator [DBS] is permitted) Estimated life expectancy less than 1 year
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-35.0,  Vestibulodynia non pregnant women between 18-35 naïve to HCs or other hormonal medications Patients able to provide Informed Consent and complete questionnaires Patient intends to use HCs for at least one year On exam before initiation of HCs, patient does not have primary PVD, pelvic floor hypertonicity, vaginismus or congenital abnormalities Patient will be available for follow up appointments Patient is willing to undergo gynecologic examination, if dyspareunia develops  Patients with endocrine disturbances (including PCOS), liver diseases and eating disorders Patients who suffer from Hypertension, Migraine with aura or clotting disturbances Patients that experience pain with intercourse or tampon insertion Patients that have other contraindications for HCs use
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 10.0-80.0,  Keratoconus Evidence of corneal thinning by any type of keratometry  Corneal inflammation without evidence of ectasia Retinal disorder subjects excluded
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-0.077,  Hyperbilirubinemia, Neonatal Term or late-preterm newborn infants with GAs of ≥35 weeks and birth weights of ≥2,000 g were included  All sick newborn infants who were admitted to the intensive care unit
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Gastrinoma Glucagonoma Insulinoma Islet Cell Carcinoma Pancreatic Polypeptide Tumor Recurrent Islet Cell Carcinoma Somatostatinoma Patient must have histologically or pathologically confirmed locally unresectable or metastatic low or intermediate grade pancreatic neuroendocrine tumor, excluding small cell carcinoma Patient must have measurable disease by Response Evaluation in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to randomization and must be acquired by multiphasic CT or contrast magnetic resonance imaging (MRI) Date of last documented disease progression must be =< 12 months from date of randomization Patient must not have received prior temozolomide, dacarbazine (DTIC), or capecitabine, or 5-FU (fluorouracil) therapy Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued >= 4 weeks prior to randomization Concurrent somatostatin analogues are allowed provided that patients Have been on stable doses for 8 weeks and Have documented disease progression on that dose Patients may not be receiving any other investigational agents while on study treatment Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed