semaj83/ctmatch_classification huggingface dataset:
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Thyroid Nodule Goiter Thyroiditis Graves Disease The patient must have given his/her informed and signed consent The patient must be insured or beneficiary of a health insurance plan The patient is available for 12 months of follow-up The patient is a candidate for total thyroidectomy because of a nodular pathology, a diffuse goiter, thyroiditis, or Basedow's disease Patient has calcitoninemia < 9 ng/pl Patient has normal calcemia Patient has PTH level between 5 ng/l and 75 ng/l The subject has a normal laryngeal mobility  The patient is participating in another study The patient is in an period determined by a previous study The patient is under judicial protection, under tutorship or curatorship The patient refuses to sign the consent It is impossible to correctly inform the patient The patient is pregnant The patient is breastfeeding The patient is not available for 12 months of follow-up Subject has a preoperative diagnosis of cancer on fine needle aspiration biopsy of the thyroid or cervical lymph node Lymph node metastasis strongly suspected clinically and/or sonographically
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Graves Ophthalmopathy Clinical diagnosis of Graves Orbitopathy Clinical activity score higher than 2 Must be able to swallow tablets  sight-threatening Graves Orbitopathy Diplopia in primary gaze Macrolide allergy or intolerance
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 2.0-16.0,  Paediatric Thyrotoxicosis All patients with thyrotoxicosis aged between 2 and 16 years at the time of diagnosis. Thyrotoxicosis will be diagnosed by the paediatrician on the basis of the clinical picture and the biochemistry (suppressed TSH with high thyroid hormone levels) Child has consented/assented or consent via parent/guardian has been gained prior to any study specific procedures  Known toxic adenoma / toxic hyperplasia (germline activating TSHR mutation) McCune Albright Syndrome Previous episodes of Thyrotoxicosis Known allergic response to any of the study medication or ingredients as per SmPC Previous participation in this study
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 23.0-45.0,  Pregnancy Complicated by Hyperthyroidism Hypothyroidism in Pregnancy Autoimmune hyper or hypothyroidism, diagnosed by an endocrinologist, treated, based on clinical and laboratory tests and ultrasound thyroid examination Patients were included if they were seen by gynecologist at Clinic for Gynecology up until 20th week of gestation and not later healthy pregnant women in control group were directed for cordocentesis due to age  Any other chronic diseases
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Papillary Thyroid Carcinoma Histologically confirmed papillary thyroid carcinoma, including its variants, such as tall cell PTC or poorly differentiated thyroid carcinoma, that is metastatic or unresectable AND harbors a BRAF V600E mutation Evaluable disease, as defined by at least one lesion that can be accurately measured in at least one dimension on CT scan or ultrasound, if present in the neck Radioiodine-refractory disease Life expectancy > 6 months Able to swallow and retain oral medication Normal organ and marrow function  Pregnant or breastfeeding Previous treatment with a specific BRAF or MEK inhibitor Receiving any other study agents Known brain metastases History of allergic reactions attributed to compounds of similar chemical or biologic composition to GSK2118436, bovine TSH, mannitol or iodine Active gastrointestinal disease or other condition that will interfere significantly with the absorption of drugs History of known glucose-6-phosphate dehyrogenase (G6PD) deficiency Corrected QT interval >/= 480 msecs; history of acute coronary syndromes (including unstable angina), coronary angioplasty, or stenting within the past 24 weeks; Class II, III, or IV heart failure, abnormal cardiac valve morphology; or history of known cardiac arrhythmias Taking herbal remedies Subjects with significant symptoms from their thyroid cancer, or have a large burden of rapidly progressive iodine-refractory PTC who are in need of other systemic therapy, as judged by their treating physician
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-37.0,  Infertility Obesity Indication for IVF/ICSI for the couple Woman's age >18< 38 years at randomization First, second or third IVF/ICSI treatment BMI > or = 30.0 <35.0 kg/m2 Willing to participate and to sign informed consent  Diabetes mellitus treated with insulin Oocyte or sperm donation planned Preimplantation genetic diagnosis (PGD) treatment planned Azoospermia known at randomization Patient not having adequate knowledge of Swedish (to understand patient information and questionnaires) QEWP-R questionnaire indicating binge eating disorder for the woman Previous participation in the study
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Lacrimal Apparatus Disease Thyroid carcinoma Previous thyroidectomy  Potential causes of dry eye (autoimmune diseases, contact lens wearers or drugs that alter tear production, such as antihistamines and psychotropic) Use of other anti-neoplastic, such as 5-fluorouracil and docetaxel, which can cause epiphora and OVL Lacrimal gland / ocular trauma Radiation therapy for other diseases or radiotherapy of head and neck Patients with diseases that alter the neural control of tear secretion, hormone therapies, pterygium, Graves' disease with or without ophthalmopathy, blepharitis and other conditions that may reduce tear production or result in rapid evaporation
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Graves' Hyperthyroidism Age 18 years or older Active Graves' hyperthyroidism (suppressed TSH (< 0.1) and positive TRAb) measured within the last two months prior to the date Written informed consent  Major co-morbidity, making the participants unlikely to continuously receive trial intervention in the intervention period Previous treatment with radioactive iodine Current ATD treatment having been received for more than two months Treatment with immunomodulatory drugs, such as cyclosporine A, methotrexate, cyclophosphamide Allergy towards the components in the selenium and placebo pills Pregnant or breast-feeding women Intake of selenium supplementation above 70 µg per day (70 µg corresponds to the amount in a multivitamin tablet) Unable to read and understand Danish Lack of informed consent
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Obesity Major Depressive Disorder Dysthymic Disorder Cardiovascular Disease Female and male participants, with a BMI of 27 kg/m2 to 45 kg/m2 Age 18 years old Presence of current major depressive disorder or dysthymic disorder At least 2 CVD risk factors, as characterized by the metabolic syndrome, including Elevated waist circumference (males 40 inches or 102 cm; females 35 inches of 88 cm) Fasting blood glucose 100 mg/dL Blood pressure 130/85 mm Hg Triglycerides 150 mg/dL Reduced HDL cholesterol (males 40 mg/dL; females 50 mg/dL)  Cardiovascular event (e.g., myocardial infarction, stroke) within the past 12 months Use of tricyclic anti-depressants, monoamine oxidase inhibitors or paroxetine, mood stabilizers, or antipsychotic medications. (Note: participants who take SSRI/SNRI may be acceptable, provided they have been on a stable dose of these medications 3 months.) Use of weight-loss medications or any medications known to significantly affect weight (e.g., oral steroids) in past 3 months Weight loss of 5% or more in past 6 months Enrollment in weight reduction program in prior 3 months Treatment in individual psychotherapy for any psychiatric disorder in prior 3 months (Note: participants in couples or family counseling will be allowed.) Severe depression or severe impairment of functioning as judged by the assessor or PI Presence of active suicidal ideation Diabetes Alcohol/drug abuse/dependence
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 21.0-65.0,  Overweight and Obesity age 21 to 65 BMI 25 to 45 sleep 7 hours or less most nights  use of medications affecting sleep sleep apnea shift work
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Hypothyroidism radioiodine therapy after total thyroidectomy in differentiated thyroid cancer age over 18  kidney failure, liver failure, heart failure infection inflammation autoimmune disease other chronic disease
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 6.0-9.0,  Hyperthyroid A-For the child born to hyperthyroid mother during pregnancy  oOld from 6 to 9 years included oAge of gestation between ≥37 and <41 weeks of amenorrhoea oBorn from a mono-foetale pregnancy oEuthyroïd at the time of the entry in the study oProvided education for at the elementary school on a level adapted to its age B-For hyperthyroid mother during pregnancy  oHyperthyroïd during pregnancy (transitory gestation hyperthyroid or disease of Basedow) oEuthyroïd at the time of the entry in the study C-For the child born to euthyroid mother during pregnancy  oOld from 6 to 9 years included oAge of gestation between ≥37 and <41 weeks of amenorrhoea oBorn from a mono-foetale pregnancy oEuthyroïd at the time of the entry in the study oProvided education for at the elementary school on a level adapted to its age D-For euthyroid mother during pregnancy  Euthyroïd at the time of the entry in the study  A-For the child born to hyperthyroid mother during pregnancy  Discovered of a thyroid dysfonction at the time of the entry in the study B-For hyperthyroid mother during pregnancy Discovered of a thyroid dysfonction at the time of the entry in the study C-For the child born to euthyroid mother during pregnancy Discovered of a thyroid dysfonction at the time of the entry in the study D-For euthyroid mother during pregnancy oDiscovered of a thyroid dysfonction at the time of the entry in the study oCarrying anti-TPO antibody at the time of the entry in the study
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Atrial Fibrillation Subclinical Hyperthyroidism Atrial fibrillation or AV-nodal reentry tachycardia Fulfills for ablation (severe arrhythmia symptoms; for atrial fibrillation patients, having tried at least one antiarrhythmic agent with poor effect) Admitted for ablation for the first time Has left blood samples for thyroid status (TSH, free T4, free T3)  Atrial flutter Overt hyperthyroidism
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Obesity, Morbid volunteers from Central Norway if female: taking oral contraceptives or post-menopausal body mass index 30-45 kg/m2 stable weight (<2kg variation in the last 3 months) not currently dieting to lose weight  Pregnancy breast feeding drug or alcohol abuse within the last two years current medication known to affect appetite or induce weight loss enrollment in another obesity treatment program history of psychological disorders history of eating disorders history of diabetes type 1 or 2 gastrointestinal disorders (particular cholelithiasis) kidney -, liver -, lung
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 21.0-75.0,  Focus of Study: Prevent Pulling Sensation and/or Swallowing Difficulty in Patients Received Total Thyroidectomy. Age 21-75 Histological confirmation of differentiated thyroid cancer requiring surgery, symptomatic goiters, thyroid nodules requiring histological analysis, or thyrotoxicosis poorly controlled by medication Undergoing total thyroidectomy  Previous neck surgery Previous neck radiotherapy Patients with a known history of keloids Patients with a known history of motility disorders in the upper gastrointestinal tract and preexisting swallowing difficulty Patients with metastatic disease; patients with disease that would require postop radiation therapy, radionuclide iodine therapy and any adjuvant therapies Patients with advanced disease that would require radical or modified neck dissection Patients with lobe larger than 10 cm, or nodule larger than 8 cm which require extensive dissection that may confound the study Patients with connective tissue diseases and chronic diseases on long-term medications that may interfere with wound healings such as steroids
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 20.0-45.0,  Healthy Pharmacokinetics of ASP7991 Healthy, as judged by the investigator/sub investigator based on the results of physical examination obtained before study drug administration Body weight: ≥50.0 kg, <80.0 kg BMI: ≥17.6, <26.4 Serum corrected calcium concentration: ≥9.0mg/dL, <10.4 mg/dL  Received any investigational drugs in other clinical or post-marketing studies within 120 days before screening Donated 400 mL of whole blood within 90 days, 200 mL of whole blood within 30 days, or blood components within 14 days before screening Received medication (including marketed drug) within 7 days before hospitalization, vitamin preparation including vitamin D and supplement including calcium or is scheduled to receive medication A deviation from normal range of 12-lead ECG (QT evaluation) A deviation from the normal range in clinical laboratory tests Highly sensitive cardiac troponin T (at screening): ≥0.014 ng/mL History of drug allergies Upper gastrointestinal disease (e.g. nausea, vomiting, stomachache) within 7 days before admission Concurrent or previous hepatic disease (e.g., viral hepatitis, drug-induced liver injury) Concurrent or previous endocrine disorders (e.g., hyperthyroidism, aberration in growth hormone)
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Graves' Disease Out-patients 18 years of age or over, who have given written informed consent to participate in the study Diagnosed with Graves' disease Received radioiodine for treatment of Graves' disease Had a minimum of 12 months follow-up after RI Most recent RI dose 5 years ago or less at the time of enrollment  Patients unable to give informed consent Age 17 years or younger Cause of thyrotoxicosis other than Graves' disease Patients who have had more than one dose of radioiodine can only be included in the study once, using data pertaining to their most recent treatment episode Patients who might not adequately understand verbal explanations or written information given in English, or who have special communication needs
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 45.0-999.0,  Hypertonia Resistant Hypertension > 140 / > 90mmHg age : 45 + Regular monitoring of blood levels considered pre-medication to lower blood pressure for at least 3 weeks before the preliminary investigation consistent Men and Women  derailed diabetes renal impairment , renal creatinine clear <50 ml Non austherapierte cancer / tumor patients Non adjusted thyroid dysfunction BMI> 35 LVEF <limit ( " 35% " ) Peripheral AVK ( ABI measurement ) > Stage II
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 25.0-55.0,  Obesity MRI compatibility 55 yrs old 40 BMI weight stable right handed  MRI incompatibility left handed
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Other Impaired Renal Function Disorder Normal Renal Function  Abnormal Renal Function Renal metastasis
Patient description: A 46-year-old woman presents with a 9 month history of weight loss (20 lb), sweating, insomnia and diarrhea. She reports to have been eating more than normal and that her heart sometimes races for no reason. On physical examination her hands are warm and sweaty, her pulse is irregular at 110bpm and there is hyperreflexia and mild exophthalmia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Hyperthyroidism Hypothyroidism informed consent, female sex, age 20-85 years, indication for treatment of the thyroid disorder  pregnancy, renal insufficiency, known osteoporosis, other disease that may affect bone metabolism, medication which affects bone metabolism, T-score below -3.5, thyroidea ophthalmopathy with indication for steroids