semaj83/ctmatch_classification huggingface dataset:
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Chronic Obstructive Pulmonary Disease, COPD Main Written informed consent Patients with a history of chronic obstructive pulmonary disease for at least 12 months as defined by the GOLD (Global Initiative on Obstructive Lung Diseases) (2003) Age ≥ 40 years FEV1/FVC ratio (post-bronchodilator) ≤ 70% FEV1 (post-bronchodilator) ≤ 65% of predicted FRC (post-bronchodilator) ≤ 120% of predicted Clinically stable COPD within 4 weeks prior to baseline visit (B0) Availability of a chest x-ray dated a maximum of 6 months prior to study baseline visit (B0) or a willingness to have a chest x-ray performed at visit (B0) Main  COPD exacerbation indicated by a treatment with systemic glucocorticosteroids not stopped at least 4 weeks prior to the baseline visit (B0) Non smoker, current smoker or ex-smoker (smoking cessation at least one year ago) with a smoking history of < 10 pack years Suffering from any concomitant disease that might interfere with study procedures or evaluation Lower respiratory tract infection not resolved 4 weeks prior to the baseline visit (B0) Diagnosis of asthma and/or other relevant lung disease (e.g. history of bronchiectasis, cystic fibrosis, bronchiolitis, lung resection, lung cancer, interstitial lung disease [e.g. fibrosis, silicosis, sarcoidosis], and active tuberculosis) Current participation in a pulmonary rehabilitation program or completion of a pulmonary rehabilitation program within 2 months preceding the baseline visit (B0) Known alpha-1-antitrypsin deficiency Need for long term oxygen therapy defined as ≥ 15 hours/day Clinically relevant abnormal laboratory values suggesting an unknown disease and requiring further clinical evaluation (as assessed by the investigator) Known infection with HIV, active hepatitis and/or liver insufficiency
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 0.167-1.0,  Bronchiolitis Any child 2-12 months old seen in the emergency department A clinical bronchiolitis score > 3 by modified Wood's Clinical Bronchiolitis Score (M-WCBS) Diagnostic of bronchiolitis includes tachypnea, cough, prolonged expiratory phase, wheezing, rales, chest retractions, and hyperinflation of lungs on chest radiograph. After consenting a patient to the study, respiratory syncytial virus (RSV) infection will be tested by rapid enzyme-linked immunoabsorbent assay of nasal secretions  No child will be excluded based on race or gender Patients under the age of 2 months or greater than 12 months Patients with cyanotic heart disease Patients with lobar pneumonia, defined by results of chest radiographs The presence of interstitial disease or diffuse patchy marking consistent with atelectasis on chest radiographs will not patients Patients with croup Patients with foreign body aspiration Patients with history of cystic fibrosis, bronchopulmonary dysplasia or other chronic lung disease Patients with liver or renal disease Patients with sickle cell anemia
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 45.0-999.0,  Chronic Obstructive Pulmonary Disease Acute exacerbation of COPD type I or II according to GOLD Ability to perform lung function tests Ability to take oral medication  Pregnant or lactating women, or women of childbearing age not using an acceptable method of contraception Pretreatment ( > 24 hours) with an antibiotic for the present exacerbation Pretreatment with corticosteroids (>30 mg for more than 4 days) for the present exacerbation Progression or new radiographic abnormalities on the chest X-ray Severe exacerbation that required mechanical ventilation History of bronchiectasis Recent or unresolved lung malignancy Other disease likely to require antibiotic therapy Significant gastrointestinal or other conditions that may affect study drug absorption Class III or IV congestive heart failure or stroke
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Asthma Chronic Obstructive Pulmonary Disease Physician-diagnosis of asthma, COPD exacerbation, or undifferentiated asthma/COPD exacerbation Admitted to the inpatient medical service at Johns Hopkins Hospital or Johns Hopkins Bayview Medical Center Evidence of airflow obstruction on spirometry (FEV1/FVC<70%) Age 18 years or older  History of allergy or other contraindication to macrolides (azithromycin, erythromycin, clarithromycin) Treatment with any macrolide in the 4 weeks prior to study entry Elevated AST or ALT (2 or more times the upper limit of normal) on current admission Elevated alkaline phosphatase (>1.25 times the upper limit of normal) on current admission Elevated total serum bilirubin (more than upper limit of normal) on current admission Previous participation in this study Patients prescribed digoxin (azithromycin may increase digoxin levels) Patients prescribed warfarin (azithromycin may increase INR in patients on warfarin) Patients prescribed pimozide (azithromycin may increase risk of arrhythmias) Patient unable to provide consent (e.g., language difficulty or history of dementia)
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Asthma Chronic Obstructive Pulmonary Disease (COPD) Undifferentiated Asthma/COPD Age 18 years and older Admission to the inpatient medical service Physician-diagnosed asthma or asthma/COPD or COPD exacerbation Evidence of airflow obstruction on spirometry  More than 24 hours since admission to the inpatient medical service Admission to an intensive care unit Hospital discharge planned within the next 24 hours Other chronic respiratory disease (e.g., sarcoidosis, idiopathic pulmonary fibrosis) Chest wall abnormalities (e.g., severe kyphoscoliosis) that precludes using the vest Chest wall or abdominal trauma/surgery in the past 6 weeks that precludes using the vest Physician declines to provide consent Patient unable (e.g., history of cognitive impairment, unable to understand English) or declines to provide consent Previous participant in this study Corticosteroid therapy (prednisone >0 mg/d equivalent) for >1 week prior to admission
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Chronic Obstructive Lung Disease (COLD) Patients included are those with documented or suspected COLD, exclusive of other bronchial or lung disease, and admitted for acute exacerbation, in the absence of overt sepsis or broncho-pneumonia, and having no other organ  Patients recently hospitalised, having received antibiotics since more than 24h, or on long-term steroids will not be included
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  COPD clinical COPD smoking age > 40 years  age < 40 years use of antibiotics, corticosteroids or beta-agonists
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  COPD Acute Exacerbation COPD patients who were admitted to our pulmonary department for an acute exacerbation were prospectively enrolled in the study  COPD patients hospitalized with specific reasons like pneumonia, pulmonary emboli, congestive heart failure, pneumothorax etc. as the cause of acute exacerbation, or patients with risk of imminent respiratory failure requiring mechanical ventilation or direct admission to the ICU were excluded
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Chronic Obstructive Pulmonary Disease Smoker or ex smoker of at least 10 pack years Age 40 or above Prior and current use of inhaled corticosteroids for at least 6 months duration (Used for at least 75% of time on direct questioning) FEV1 <80% of predicted, FEV1/FVC ratio <70% Less than 15% change and <200 mls change in FEV1 20 minutes after 5 mg nebulised salbutamol patients to be included in trial of which 196 must have had a precious exacerbation of COPD in the last year  Clear history of asthma, bronchiectasis, carcinoma of bronchus or other significant respiratory disease Inability to give informed consent (severe mental illness, mental handicap or brain damage) Recorded exacerbation within last month that has required antibiotics or steroids (delayed randomisation) Classification as a never smoker Strongly positive skin allergy result (>10mm skin weal greater then negative control) to house dust mite, grass, tree, aspergillus, cat, dog or weed (irrespective of asthma/atopy status)
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 6.0-12.0,  Attention Deficit Disorder With Hyperactivity Tourette Syndrome Diagnosis of ADHD or ADHD plus Tourette syndrome  Determined to be dangerous to self or others Scores less than 70 on an IQ test Any seizure disorder, major organic brain dysfunction, major medical illness, major mood disorder, psychosis, pervasive developmental disorder, or peripheral sensory loss Any condition that may make use of methylphenidate unsafe
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 0.167-4.917,  Severe Pneumonia Age: 2 to 59 months Sex: Both boys and girls Severe pneumonia according to WHO (Severe pneumonia is defined as cough or difficult breathing with lower chest wall in drawing with or without fast breathing which is defined as the respiratory rate ≥ 50 breaths per minute for children aged 2-11 months and ≥ 40 breaths per minute for children aged 12-59 months) Attend the Radda Clinic and ICHSH between 8:00 am to 4:00 pm (Sunday through Saturday) Written informed consent by respective parents/guardians  Very severe and non-severe pneumonia Nosocomial pneumonia History of taking antibiotics for pneumonia within 48 hour prior to enrollment Chronic illnesses like tuberculosis, cystic fibrosis Congenital deformities/anomalies e.g. Down's Syndrome, congenital heart disease Immunodeficiency Trauma/burn Bronchiolitis Bronchial asthma Lives far away from the Radda Clinic and ICHSH (outside 5 km radius from the respective study site)
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 45.0-70.0,  Quality of Life Exercise Moderate COPD (GOLD classification) , AGE 45-70, both sexes Treated with inhaled steroids and long acting beta agonists  Active ischemic heart disease, heart failure, orthopedic problems that preclude ergometric bicycle activity
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Asthma COPD Male or female (medically or surgically postmenopausal or practicing an accepted form of barrier or hormonal contraception) subjects between 18 years Any severity of exacerbation of obstructive airway disease attending the outpatient clinic History of at least two exacerbations in the past 12 months prior to recruitment that required a course of prednisone or antibiotic or long acting bronchodilator or inhaled corticosteroid, in addition to the daily maintenance therapy Signed written informed consent to participate in the protocol and ability to return to the outpatient clinic for repeated clinic visits  If the exacerbation is severe enough to warrant hospitalization Active malignancy Significant gastrointestinal, hematological, cardiovascular or cerebrovascular disorder that would affect compliance with follow up visits Recent (within the past 2 months) or planned (within the study period) lung surgery Psychosis, alcoholism, active substance abuse or any personality disorder that would make compliance with the follow up visits problematic Pregnant or nursing females, as this could affect the compliance during the trial Any other medical or social condition, which in the opinion of the investigator could confound the interpretation of the data derived from this study
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Asthma Pulmonary Disease, Chronic Obstructive No change from the MIA and LEUKO trials  No change from the MIA and LEUKO trials
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  COPD Patients admitted with COPD exacerbation
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 35.0-999.0,  Chronic Obstructive Pulmonary Disease (COPD) A software program using Anatomical Therapeutical Chemical (ATC) prescription codes and International Classification of Primary Care (ICPC) diagnosis codes selected potential patients with COPD. age >35 years and a diagnosis recorded as COPD or as ICPC code R95/96, or a prescription of at least three times of bronchodilators (ATC code R03a/bc) and/or prescription of at least two times of inhaled anti-inflammatory medication in the past year (ATC code R03). General practitioners (GPs) had to confirm the diagnosis of the selection. Patients were eligible to participate if they met the following Current smoking Suffering from COPD according to the GP's diagnosis In command of the Dutch language  Too ill Under control of a chest physician Serious physical or psychological comorbidity
Patient description: A 63-year-old man presents with cough and shortness of breath. His past medical history is notable for heavy smoking, spinal stenosis, diabetes, hypothyroidism and mild psoriasis. He also has a family history of early onset dementia. His symptoms began about a week prior to his admission, with productive cough, purulent sputum and difficulty breathing, requiring him to use his home oxygen for the past 24 hours. He denies fever. On examination he is cyanotic, tachypneic, with a barrel shaped chest and diffuse rales over his lungs. A chest x-ray is notable for hyperinflation with no consolidation.

Clinical trial eligibility criteria: eligible ages (years): 40.0-80.0,  Chronic Obstructive Pulmonary Disease Phase 1 & Gene Expression: --Current hospitalization for COPD exacerbation Phase 1 & 2: COPD & ONE of the following History of hospitalization for COPD exacerbation, OR Currently on supplemental oxygen, OR History of evaluation for lung transplant or LVRS, OR >/= 6 months post-LVRS Phase 1 or 2 Current or former smoker, >/= 20 pack-yr. smoking history FEV1 </= 70%; FEV1/FVC </= 70% Life expectancy of > 6 months  < 20 pack-yr. smoking history Diagnosis of pulmonary fibrosis, bronchiectasis, mediastinal mass, or presence of a pulmonary mass Asthma FEV1 > 70% or FEV1/FVC >70%