Patient description: A 46-year-old Asian woman with MDD complains of persistent feelings of sadness and loss of interest in daily activities. She states that her mood is still depressed most of the days. She complains of loss of energy and feelings of worthlessness nearly every day. She is on anti-depressants for the past 6 months, but the symptoms are still present. She does not drink alcohol or smoke. She used to exercise every day for at least 30 min., but she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was diagnosed with colon cancer a year ago and is undergoing chemotherapy. Her past medical history is unremarkable. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Developmental Articulation Disorder Speech Disorder Stuttering i. Normal Language Development, Hearing and Cognition ii. The following screening tests previously published with norms were found to have a good distribution for determining normal functioning in adolescents and adults as all subjects did not hit ceiling and all had scores greater than or equal to the 80th percentile. These tests are being used to ensure that subjects affected with stuttering or FPPD do not have other disorders such as hearing loss, language delay, or mental retardation. Peabody Picture Vocabulary Test III (PPVT-III) Expressive Vocabulary Test (EVT) Oral Speech Mechanism Screening Examination Revised Token Test; Token test for Children Test of Non verbal intelligence (TONI-2) Digit Span subtest of the WICS-R Audiometric Screening Goldman Fristoe Test of Articulation WUG Test of Morphological Encoding Test of Auditory Comprehension of Language (TACL) Khan-Lewis Phonological Analysis FOR AND The Stuttering Severity Index -3 (Riley, 1981) has been found to be accurate for identifying and assessing the severity of stuttering during conversational speech. For the of a stuttering subject we require: i. A total overall score of 11 or greater between 3 and 17 years, ii. A total overall score of 18 or greater from age 18 and above. FOR FPPD: i. A family history of an autosomal dominant pattern of inheritance of the speech disorder over several generations with persistence into adulthood in some cases, ii. Speech symptoms during conversational speech deletion of final consonants; syllable reduction and syllable deletion; deletion of grammatical markers such as copulas, auxiliaries, prepositions, connectives; poor ability to self-correct; poor awareness of errors; and consonant cluster reduction. iii. Greater than 9% discourse errors during analysis of a sample of 300 syllables. iv. A discrepancy of 30 points (1 and 1/2 Standard Deviations) between receptive (the higher score) and expressive percentile score on the PPVT III and Expressive Vocabulary Test. v. For subjects greater than 7 years of age, a phonological process rating of 3 or more for any phonological process on the Khan-Lewis Phonological Analysis. For subjects less than 7 years of age, a phonological process rating of 3 or more on 2 phonological processes on the Khan-Lewis Phonological Analysis. Finally, any subjects with a non developmental phonological process error will be identified as potentially having FPPD  i. Anyone with a hearing loss will be excluded from participation during the diagnostic testing. ii. Children with delayed language, more than 1 year delay from norms on receptive and expression language testing will be excluded. iii. Language impairment: scores more than 2 standard deviations below the age appropriate score on the standardized language tests listed under the criteria. iv. Cognitive impairment: scores more than 2 standard deviations below the age appropriate score on the standardized cognitive tests listed under the criteria. v. Bilingual non-native English speakers Studies have demonstrated that brain organization for speech and language may differ in bilingual persons. It is hypothesized that this may alter speech motor learning and thus kinematic data from non-native English speakers would differ from native English speakers. Therefore, only native-American English speakers, with only one language spoken in the home, will be included