semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 21.0-999.0,  Essential Tremor patients with a clinical diagnosis of essential tremor will participate in the study. Selection criterion is essential tremor with a history of ethanol responsiveness. Informed consent will be obtained by any of the co-investigators. Patients must be off any medications used to treat essential tremor such as mysoline or propranolol for at least 2 weeks. Patients must withhold ethanol and caffeine 24 hours prior to starting the treatment periods through the end of treatment periods, including alcohol or caffeine containing over the counter medications. Ethanol and caffeine consumption is allowed in the washout period  Patients with abnormalities on neurologic exam other than tremor. Patients with a history of chronic alcohol dependence. Patients with chronic medical conditions such as renal failure, hepatic failure and chronic lung disease. Patients on other medications that cannot be temporarily discontinued for the length of the study. Patients, who, for moral or religious reasons, do not wish to take a potentially intoxicating drug. Patients with abnormalities on their baseline screening laboratory tests. Women who are pregnant or lactating. Patients under the age of 21. Asians and Pacific Islanders
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Granulomatous Disease Chronic   The recipient fulfills by study design the The patient however, would be considered ineligible for the study only If his donor is unable to participate. DONOR Pregnant or lactating Donor unfit to receive G-CSF and undergo apheresis. (Uncontrolled hypertension, history of congestive heart failure or unstable angina, thrombocytopenia) HIV positive
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 21.0-999.0,  Essential Tremor Patients with alcohol-responsive Essential Tremor Limb involvement should be a prominent feature of the Essential tremor Patients must be willing and able to safely stop and remain off any medications used to treat essential tremor for at least 4 half-lives Patients must be willing to abstain from ethanol and caffeine intake for at least 48 hours prior to starting the study hospitalization until study termination Patients must be willing and able to fast for periods of up to 12 hours during the study  Patients with abnormalities other than tremor on neurological exam Patients with active or past alcohol abuse or dependence Patients with acute or chronic severe medical conditions such as renal failure, hepatic failure or lung disease Patients taking primidone Patients on other acute or chronic medications that influence hepatic metabolism or central nervous system (CNS) function and cannot be temporarily discontinued for the length of the study Patients who do not wish to take a potentially intoxicating drug Patients with abnormalities on their baseline screening laboratory tests Women who are pregnant or lactating Patients younger than age 21 The presence of cognitive impairment preventing informed consent or cooperation during the study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 14.0-65.0,  Tourette Syndrome FOR Subjects will be normal volunteers with no history of neurological disorders; they will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have a neurological and physical examination. Subjects will be male or female, in age ranges 14 to 65 years old. FOR Patients ages 14 to 65 with a clinical diagnosis of tourette syndrome or chronic motor tic disorder as defined by DSM-IV-TR and evaluation of tic severity using the Yale Tic Scale (YGTSS). This criterion will be established by preliminary screening in the NINDS Movement Disorders Outpatient Clinic. Structure Clinical Interview for (DSMIV SCID) will be administered to all subjects to ensure that strict DSM-IV for Tourette syndrome have been met and to assess for possible comorbid psychiatric disorders. Patients with at least moderate premonitory urge, as evaluated with the PUTS. Patients with sensory tics, either bilaterally or unilaterally, in the facial region  FOR AND Cardiac pacemaker / cardiac or neural defibrillators. Metal fragments in the eyes. Metal plates, pins, or bolts in the head. Any magnetic implantation / implantations made from iron (ferrous products). Hearing problems. Problems using response devices. Subjects younger than 14 or older than 65 years. Subjects with 1 ) major depression, 2) bipolar disorder, or 3) psychotic disorder. Subjects taking benzodiazepines, anti-depressant or neuroleptic medications. Subjects with major acute or chronic illness, or subjects for whom sitting in a still position for an extended period of time would trigger or exacerbate a preexisting condition or cause any undue harm or discomfort. Pregnant women (steroidal hormones have been shown to influence EEG (Rupprecht et al., 2001). Patients with severe head tics or subjects who are unable to hold their head still in a scanner for at least 70 seconds
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Articular Cartilage Provided written informed consent Documented history of at least one Grade III or Grade IV defect (modified Outerbridge classification) on the medial or lateral femoral condyle or trochlea Failed prior treatment for articular cartilage defects of the knee, e.g. inadequate response to a non ACI surgical procedure to treat the lesion, within past 3 yrs Patient reported overall knee condition of 5 or less on the Modified Cinn Rating System patients must have had a cartilage defect located on the medial or lateral femoral condyle or trochlea which had an inadequate response to a prior arthroscopic or other non-Carticel surgical repair procedure  see above
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Lymphadenitis Kikuchi's disease
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 1.0-999.0,  Wilson's Disease Wilson's disease(adult, infant, pregnant woman)  Acute hepatitis Malignant tumor
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 1.0-999.0,  Wison's Disease Wilson's disease(adult,infant,pregnant woman)  acute hepatitis malignant tumor
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Nasal Polyps Gastroesophageal Reflux Subjects will Be adults with nasal polyposis recruited from the PI's private practice Not be currently taking a PPI Be able and willing to undergo a noninvasive 24 hour pH probe study; and Take a PPI  Patients who Are pregnant Have a history of surgical treatment for reflux disease History of allergic or adverse reaction to Prevacid or adverse reaction to Prevacid during the study period; and Do not meet criteria
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Essential Tremor age 18 or older diagnosis of essential tremor tremor present in both hands for at least one year tremor is bothersome in at least one hand, so that reduction of tremor would improve quality of life able to comply with study visits and procedures has voluntarily signed consent form able to abstain from alcohol for 12 hours prior to each visit, and from caffeine on day prior to visit taking no medications or stable doses of anti-tremor medication for 4 weeks prior to the Baseline visit  medical condition likely to cause hospitalization during the study progressive neurological disorder other than essential tremor history of serious psychiatric illness history of drug or alcohol abuse in past year consumes more than two glasses of wine or equivalent per day has received botulinum toxin injection in past 6 months currently using experimental device has taken experimental drug within 5 half lives of its elimination has received deep brain stimulation in past two weeks or has potential need for this therapy during the study thalamotomy within the past 6 months
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Essential Tremor Current symptoms of essential tremor based on the Tremor Investigational Group (TRIG) Dominant upper extremity posture or action intention tremor of 2 (moderate) to 4 (severe) In good health otherwise  Patients with abnormal neurologic signs other than essential tremor Taking more than one anti-tremor medication Taking drugs known to cause tremors With physical damage to the nervous system or Parkinson's disease Known to be abusing drugs or alcohol Women who are pregnant or breast-feeding
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Stroke Between the ages of 18 and 80 years. Substantial unilateral motor impairment, defined by MRC scores less than or equal to 2 At least 12 months post thromboembolic non-hemorrhagic hemispheric or hemorrhagic hemispheric subcortical lesions TBI At least 12 months post mild to moderate traumatic brain injury Between the ages of 18 and 80 years  We will any stroke patient, TBI patient, or healthy volunteer if one of the following applies: History of alcohol or drug abuse. History of epilepsy (TMS and tDCS components only). Pregnancy MRI contraindications. Cardiac pacemakers. Intracardiac lines. Implanted medication pumps. Neural stimulators. Eye, blood vessel, cochlear, or eye implants. Increased intracranial pressure as evaluated. Metal in the cranium except in the mouth. Dental braces. Metal fragments from occupational exposure. Surgical clips in or near the brain. Inability to perform study tasks. Serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 23 or less) that would prevent their ability to give informed consent and/or perform the study tasks. Uncontrolled medical (e.g. cardiovascular disease expressed as uncontrolled arrhythmias, shortness of breath, or overt signs of severe peripheral edema at the initial neurological exam, severe rheumatoid arthritis, arthritic joint deformity, active cancer or renal disease), or psychiatric problems as defined in the DSM IV TBI Post-traumatic seizures (TMS component only). Instability of psychoactive medication in the past 2 months. Pending litigation regarding the trauma. Absent changes in both Glascow Coma Scale and mental status following injury. Outpatients who are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia Cerebellar lesions. More than one stroke in the middle cerebral artery territory. Bilateral motor impairment. Initiation of an exercise or rehabilitation program that could affect experimental results. Outpatients who are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia Inability to make a 12-week commitment
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Osteoarthritis, Knee Rheumatoid Arthritis yrs. or older ACR for KOA or RA Able to speak and read English Able to ambulate at least household distances  Planned total joint replacement surgery in the next 2 years Contraindication to physical activity due to co-morbid condition Unable to perform basic self-care (functional class IV) or walk household distances Planned Relocation away from Chicago area in next two years
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Lymphoma, Non-Hodgkin Histologically confirmed diagnosis of low grade NHL or transformed low-grade NHL (tumor must be CD 20 positive) Prior treatment with at least one chemotherapy regimen and have relapsed or progressed, or failed to achieve an objective response on last chemotherapy regimen Karnofsky performance status of at least 60% and anticipated survival of at least 3 months Absolute granulocyte of >/= 1,500/mm3 Platelet count of >/= 100,000/mm3, and not require sustained support of hematopoietic cytokines, or transfusion of blood products Adequate renal function (i.e., <1.5x Upper Limit of Normal), and hepatic transaminases (AST <5 times ULN) Signed IRB/IEC-approved informed consent  Patients with a mean of >25% of the intratrabecular marrow space involved with lymphoma Patients who received cytotoxic chemotherapy, radiation therapy, immunotherapy, or cytokine treatment within 4 weeks prior to study entry (6 weeks for nitrosurea compounds) or who exhibit persistent clinical evidence of toxicity Patients who have undergone stem cell or bone marrow transplant, active obstructive hydronephrosis, active infection, New York Heart Association Class III or IV heart disease or other serious illness that would preclude evaluation Known HIV infection Pregnant or nursing patients Patients with prior malignancy other than lymphoma, except for adequately-treated skin cancer, in-situ cervical cancer, or cancer for which the patient has been disease-free for 5 years Patients with progressive disease within 1 year of irradiation arising in a field that has been previously irradiated with more than 3500 cGy Patients who received prior radioimmunotherapy, known brain or leptomeningeal metastases, HAMA positivity Patients who are receiving either approved or non-approved (through another protocol) anti-cancer drugs or biologics