Patient description: The patient is a 15 year old girl with the history of recurrent bilateral headache. The attacks come 2 times or more per week and each episode lasts around a day or a half. The pain is pulsating in quality and severe in intensity, causing trouble in her routine physical activity. The attacks are associated with nausea and photophobia. She recently noticed that that there are more attacks around her menstrual period. She is diagnosed with the migraine headache and is under treatment. She is a high-school student and living with her both parents. She is a book worm and spend her free time in a public library near her home. She is also interested in writing stories and has several short stories in English. She rarely does exercise. Her BMI is 21 with the BP of 100/60. There is nothing remarkable in her physical exam.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Migraine Disorders Female or male out-patients aged between 18 and 65 years 2. Diagnosis: Headache 1. Tension type headache according to international headache society (IHS) Headache Classification 2.1 (2.1.1 and 2.1.2) and/or 2. Migraine according to IHS Headache Classification 1.1, 1.2.1 or 3. Either a) or b), but cannot be distinctly classified 3. The patient normally treats his/her headache successfully with non-prescription analgesics 4. He/She has been suffering from headache for 12 months at least 5. The headache first occurred before the age of 50 years 6. During the previous three months, the patient has suffered from headache twice a month at least 7. Informed consent according to §§ 40, 41 of the german medicines act and Good Clinical Practice (GCP) 8. The patient seems likely to comply  The patient treats his/her headache with prescription-only analgesics or migraine remedies 2. The patient requires higher single doses of non-prescription analgesics to treat his/her headache than indicated in the patient information leaflet (e.g. more than 2 tablets of Thomapyrin tablets) 3. The patient normally treats his/her headache with non-prescription analgesics in effervescent tablet form 4. The patient normally takes his/her non-prescription analgesics immediately at the onset of the first signs of a headache episode 5. Headache occurs on more than 10 days per month 6. The typical, untreated headache normally lasts less than 4 hours without treatment 7. Women with a close association between the occurrence of headache and menstruation (menstrual migraine) 8. Concomitant treatment with prescription-only and/or non-prescription analgesics 9. Previous or concomitant treatment with antidepressants or antipsychotic medicines (previous treatment = within the previous 4 weeks) 10. Previous or concomitant treatment with anti-rheumatic or anti-inflammatory drugs that may influence the headache symptoms (previous treatment = within the previous 4 days) 11. Treatment of concomitant illnesses with drugs containing ASA (above a daily dose of 100 mg per day), paracetamol or caffeine (e.g. for feverish common cold, etc.) 12. Migraine prophylaxis or administration of drugs, indicated for any other reasons that influence headache symptoms, e.g. Propanolol, Metoprolol, Flunarizine, Cyclandelate, Valproic acid, Serotonin antagonists (pizotifen, methysergide, lisuride), Ergotamine, Dihydroergotamine, Benzodiazepines, Magnesium, Monoamine oxidase inhibitors 13. Concomitant treatments with anti-emetics 14. Drug abuse connected with the headache (defined as the administration of analgesics or other drugs for the treatment of acute headache on more than 10 days per month) 15. Alcohol or drug abuse as defined by diagnostic and statistical manual of mental disorders (DSM-IV) 16. Pregnancy and lactation 17. Gastrointestinal ulcers 18. Pathologically increased bleeding tendency 19. Glucose-6-phosphate dehydrogenase deficiency 20. Hypersensitivity to paracetamol, caffeine, ASA, salicylates, and other anti-inflammatory/anti-rheumatic agents or other allergenic substances that are relevant to the clinical trial 21. Bronchial asthma 22. Concomitant treatment with anticoagulants (e.g. coumarin derivates, heparin) 23. Clinically relevant chronic or recurrent gastrointestinal symptoms 24. Clinically relevant liver disorders 25. Clinically relevant pre-existing renal damage 26. Gilbert's syndrome 27. Not successfully treated hyperthyroidism 28. Simultaneous participation in another clinical trial 29. Participation in another clinical trial within 4 weeks of entering this study