Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Knee Osteoarthritis Voluntary signature of the IRB approved Informed Consent 2. Unilateral or bilateral osteoarthritic male or female ages 18-80 3. Pain, swelling, and/or functional disability in the affected knee consistent with osteoarthritis in the knee joint 4. Physical examination consistent with osteoarthritis in knee joint 5. Kellgren-Lawrence grade 2 or 3 knee osteoarthritis and/or diagnostic MRI imaging of the affected knee showing osteoarthritis (i.e. chondral loss, fissuring, defect, bone marrow lesion, meniscus tear, synovial thickening, etc.) 6. Minimum of 3/10 on NPS approximately 3 days per week 7. Is independent, ambulatory, and can comply with all post-operative evaluations and visits  Previously taken the Regenexx Stem Cell Support Formula 9. Receiving active knee treatment or any knee injections of any type within 3 months prior to the study (steroids, biologics, etc) 10. Knee surgery within 6 months prior to the study 11. Currently taking or history of taking products that contain curcuminoid extract within the last 2 weeks 12. Dependent on NSAIDs or acetaminophen for exercise or daily activities 13. Currently taking or previously taken fish oil in the last 2 weeks 14. Currently taking or previously taking MSM or glucosamine in the last 2 weeks 15. Diabetic 16. Inflammatory or auto-immune based joint diseases or other lower extremity pathology (e.g., rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, polymyalgia, polymyositis, gout pseudogout) 17. Quinolone or statin-induced myopathy/tendinopathy 18. Severe neurogenic inflammation of the cutaneous nerves about the knee or thigh 19. Contraindications for MRI 20. Condition represents a worker's compensation case 21. Currently involved in a health-related litigation procedure 22. Is pregnant or breastfeeding 23. Currently taking immunosuppressive medication 24. Allergy or intolerance to study medication 25. Use of chronic opioid 26. Documented history of drug abuse within six months of treatment 27. Blood clotting disorder, taking an anticoagulant or history of cardiovascular disease 28. Has asthma 29. History of prostate cancer 29) Any other condition, that in the opinion of the investigator, that would preclude the patient from enrollment including current supplement use