semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 20.0-65.0,  Non Alcoholic Fatty Liver Disease Sedentary, non smoking, male subjects Alcohol consumption men <21 units/week BMI 27-35. (Lean individuals do not suffer from NAFLD, so are not suitable for this study. Conversely, we are restricted to a maximum BMI of 35 due to the size limitations of the MR scanner.) A clinical diagnosis of NAFLD based upon the following i) of other causes of liver disease i.e. negative Hepatitis B and C serology, a negative auto-immune profile and normal caeruloplasmin concentrations, ii) Ultrasound appearances suggestive of a fatty, echo-bright liver with no evidence of cirrhosis (in some cases, the diagnosis will have been confirmed histologically after liver biopsy Being willing to engage and motivated to follow an exercise program  Prescription of corticosteroids, amiodarone, tamoxifen, methotrexate (drugs known to cause secondary steatohepatitis) or fibrates. Statin is Ok as long as the patients are on stable therapy for a while, if changed then the patient will be excluded Alcohol consumption for men 21 units/week A contraindication to exercise (such as unstable ischaemic heart disease) Type 2 diabetes (type 2 diabetes patients are excluded so that we are examining the involvement of insulin resistance at a reversible stage before β-cell failure has occurred) Patients who are on medications that will interact with GTN (glyceryl trinitrate) will be excluded from the GTN dilatation (endothelial independent NO mediated function) aspect of the study Individuals who suffer from claustrophobia and have metal implants will be excluded from the MRI aspect of the study Patients who smoke will also be excluded from the study Total cholesterol >7
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Parkinson Disease Dementia For all subjects: 1. Age 40 or older. 2. Able to abstain from caffeine and alcohol for 24 hours before each visit. 3. English is the first language. 4. Right handed For PD cohort: 1. Established diagnosis of PD. 2. History compatible with diagnosis of PD 3. Present with at least 3 of the following features: bradykinesia, resting tremor, cogwheel rigidity or postural reflex impairment 4. One of the 3 clinical features is either bradykinesia or resting tremor 5. Currently taking or history of taking dopaminergic therapy with symptomatic response. 6. Is able to give informed consent or, if there is evidence of cognitive decline, able to give assent and able to appoint a durable power of attorney (DPA) who can give informed consent  for all subjects Use of illegal drugs within the past 6 months More than 7 alcoholic drinks a week for females or 14 alcoholic drinks a week for males History of a neurologic disorder such as a brain tumor, stroke, central nervous system infection, multiple sclerosis, a movement disorder, epilepsy or a history of seizures, except PD for PD patients History of any head injury with loss of consciousness Pregnancy or positive pregnancy test before the research procedure due to the risks associated with MRI scans Inability to lie flat on the back for up to 2 hours Claustrophobia or a feeling of discomfort from being in small, enclosed spaces of enough severity to prevent MRI scanning Surgically or traumatically implanted metallic foreign bodies, such as pacemakers, implanted medical pumps, implanted hearing aids, metal plates in the skull or metal implants in the skull or eyes (other than dental fillings) that may be physically hazardous during an MRI, or might distort the images Ablative surgery or implanted electrodes and generator for deep brain stimulation
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 21.0-999.0,  Essential Voice Tremor Vocal Tremor Voice Tremor Essential Tremor of Voice Participants have a diagnosis of essential voice tremor and show signs of tremor during the endoscopy examination (when pictures of the voice box are obtained)during screening appointment Participants show measurable voice tremor from recordings of the voice during screening appointment  Participants have a diagnosis or show signs of Parkinson's Disease or another non-essential tremor movement disorder Participants have a diagnosis or show signs of spasmodic dysphonia (a different neurological voice disorder) Participants have a diagnosis of a severe, non-stable medical condition, such as kidney or liver failure, severe heart disease, severe lung disease, severe metabolic disease, uncontrolled hyperthyroidism, or other life-threatening disease such as active cancer Participants have a diagnosis of diabetes mellitus Participants are unable to suspend/stop a medication that they are currently taking for tremor or voice disorder for 12 weeks to complete this study Participants have a dependence on alcohol or allergy to alcohol Participants are pregnant or lactating Participants have an allergy to soy Participants have Irritable Bowel Syndrome
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 6.0-90.0,  Wilson's Disease Children ≥ 6 years and adult patients 2. Confirmed diagnosis of Wilson's disease by Leipzig-Score >3 (Ferenci et al 2003) 3. Current treatment with trientine dihydrochloride 4. Signed informed consent including parental consent in patients ≤ 18 years 5. Agree to remain in the study site1 for the PK measurements period  Known clinically significant allergy or hypersensitivity to drugs that, in the opinion of the investigator, may affect the patient's safety 2. Have any clinically significant conditions that would interfere with the collection or interpretation of the study results or would compromise the patient's health 3. Women of child bearing potential who do not use contraceptives, breastfeeding, or pregnant women 4. Severe anaemia (haemoglobin <9 mg/dL) 5. In the judgment of the Investigator, is likely to be noncompliant or uncooperative during the study, or unable to cooperate because of a language problem or poor mental development 6. Participation in any interventional clinical study at the same time or within the 4 weeks prior his study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Cirrhosis Hepatic Encephalopathy Ambulatory patient with cirrhosis Able to provide informed consent  History of alcohol abuse within six months Active gastrointestinal bleeding Unable to provide informed consent
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Hemochromatosis Myelodysplastic Syndromes Patients with hemochromatosis, aged > 30 years, C282Y homozygote, with serum-ferritin =/> 1000 µg/L Patients aged > 18 years with verified low-risk or intermediate-1 risk of myelodysplastic syndrome, with normal cytogenetics and serum-ferritin > 1500 µg/L, or with a transfusion history of =/> red blood-cell-transfusions  Previous or current venesection MDS patients eligible for hematopoietic stem cell transplantation Subject complies with one or more of the following standard for MRI examination If the patient has a pacemaker If the patient has a neurostimulator If the patient has a "aneurismeclips" If the patient has a foreign object in the eye. If yes, what object If the patient has a cochlea-/earimplant If the patient has a V/P shunt
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 15.0-65.0,  Schistosomiasis Mansoni Portal Hypertension Upper Gastrointestinal Bleeding age between 15 and 65 years an established diagnosis of hepatosplenic schistosomiasis as the cause of portal hypertension a history of UGIB secondary to rupture of esophageal varices, with at least 20 days having elapsed since the most recent episode of bleeding  Chronic alcoholism, defined as an alcohol intake of ≥60 g/EtOH/day in men and ≥40 g/EtOH/day in women evidence of decompensated liver disease of mixed etiology or of any chronic disease that contraindicated surgery were considered absolute the relative for were altered hemostasis (platelet count < 50×109/L or INR > 1.5) presence of fundal varices on endoscopy
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Essential Tremor Parkinson Disease Able to Sign written informed consent in Hebrew Patient agrees to attend all treatment procedures and follow-up evaluations and is willing and able to comply with all study requirements Patient with a clinical diagnosis of idiopathic PD, or ET for more than 3 years Significant tremor for at least one upper limb causing distress or disability Patient should be stable on anti-Parkinson's disease or anti-tremor medication for at least one month prior to study enrollment  Previous participation in another study with any investigational drug or device within the past 90 days Any active implant (cardiac or other) Current pregnancy or attempting to get pregnant (female patient) Patient has any major illness or medical condition that in the opinion of the physician would interfere with participation in the study Patient with other significant neurological or psychiatric disease other than Parkinson Disease or Essential Tremor Patient has any other condition expect for PD and ET that induce tremor Patient is treated with drug that may induce tremor Patient abuses drugs or alcohol Any previous thalamotomy, pallidotomy or patient who has undergone a DBS procedure Any anticipated need for surgery during the study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson's Disease Tremor Medication-refractory tremor and/or Parkinson's disease as defined by UK Brain Bank with either inadequate control of motor fluctuations or dyskinesia despite optimised medical therapy  Significant cognitive, psychiatric and medical co-morbidities Dementia with mini mental state examination score of less than 25/30 Limited life expectancy due to a co-morbid condition
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 40.0-85.0,  Parkinson's Disease A diagnosis of idiopathic Parkinson's Disease (PD) (UK, PD Brain Bank Criteria) A Hoehn and Yahr stage of 2 Exhibiting Freezing of Gait or another gait abnormality in the ON state An ability to mobilise independently with or without a walker or walking cane for the purpose of research when in the 'ON' state  A serious cognitive impairment (MMSE<24) Pregnant or currently involved in another clinical trial Pacemakers On opioid or neuropathic pain medication
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 7.0-999.0,  Limb Girdle Muscular Dystrophy Type 2D (LGMD2D) Subjects age 7 or older; cohort 1A must be adult and wheelchair-dependent Proven alpha-sarcoglycan deficiency by muscle biopsy or DNA testing Onset of weakness by 5 years age based on history of difficulty running, jumping and climbing stairs Subject enrolled in Cohort 1A must be adult and wheelchair dependent Subjects enrolled in Cohorts 1B or 2 must be able to walk independently, but must exhibit signs of lower extremity weakness (i.e. a Gowers' sign, use a handrail for climbing stairs) and walk ≤ 80% of predicted distance on the 6MWT based on normative data Males and females of any ethnic group will be eligible Ability to cooperate with muscle testing Willingness of sexually active subjects with reproductive capacity to practice reliable method of contraception (If appropriate), during the first six months after gene therapy (females) or until two negative sperm samples are obtained post gene transfer (males)  Active viral infection based on clinical observations The presence of SGCA mutations without weakness or loss of function Symptoms or signs of cardiomyopathy, including Dyspnea on exertion, pedal edema, shortness of breath upon lying flat, or rales at the base of the lungs Echocardiogram with ejection fraction below 40% Serological evidence of HIV infection, or Hepatitis A, B or C infection Diagnosis of (or ongoing treatment for) an autoimmune disease Abnormal laboratory values considered clinically significant (GGT > 3XULN, bilirubin ≥ 3.0 mg/dL , creatinine ≥ 1.8 mg/dL, Hgb < 8 or > 18 g/Dl; WBC > 15,000 per cmm) Concomitant illness or requirement for chronic drug treatment that in the opinion of the PI creates unnecessary risks for gene transfer Pregnancy
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Essential Tremor Diagnosed with essential tremor Currently taking medication to control tremor  Cognitive limitations that prevent comprehension or execution of study protocol
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Wilson Disease Movement Disorders Repetitive Transcranial Magnetic Stimulation Wilson disease with focal right hand dystonia No modification of medical treatment for 6 months No botulinum toxin administration within the past four months Right handed Focal right hand dystonia Cerebral Magnetic Resonance performed the last 6 months with no other lesion than met in Wilson disease Over 18 Insurance policy holder Informed consent  Pregnant woman Guardianship procedure Seizure history Other cerebral lesions on cerebral MRI than met in Wilson Disease Unable to stay quiet for 30 minutes Handwriting impossible Contra-indications to repetitive Transcranial Magnetic Stimulation