Patient description: 19 yo Hispanic female G1P1 at 32+ 6 weeks of gestational age presented to the OB clinic for routine follow up complaining of mild headache and leg swelling. Primary evaluation revealed BP of 146/99 and urine dipstick with 3+ proteins. Her BP and U/A were normal in previous visit. Repeat BP a few hours later is 150/100 mmHg. Laboratory studies showed a normal hematocrit, platelet count, and liver transaminase levels. She is complaining of fatigue but no fever or chills. She is also suffering of headaches with no vision changes. No shortness of breath, cough, chest pain, orthopnea and palpitations or skin rash were observed. Her physical exam was negative for abdominal pain, change in bowel habits, nausea, vomiting, dysuria, frequency, hematuria or frothy urine. Leg swelling was observed with no arthralgia or back pain. She has no specific past medical issues and only uses prenatal vitamins. Her family history is positive for DM type 2 and HTN. She is a social alcohol consumer with the negative history of smoking or drug use. She is only have one partner in past 2 years and didn't have any contraceptive methods since 2 years ago. Her BMI was 24 at the first

Clinical trial eligibility criteria: eligible ages (years): 18.0-35.0,  Schizophrenia Males or females between 18 and 35 years old (History) 2. Absence of current (i.e. last six months) psychiatric conditions (including alcohol and drug abuse). Subjects with a history of a non-psychotic psychiatric disorder who have been asymptomatic and not taking medication for the past 6 months may be eligible. (History, SCID-NP (non-patient version)) 3. A negative urine toxicology with the exception of cannabis; in the case of a positive urine cannabis test a salivary cannabis test will be administered on the day of the PET scans to ensure subjects have not used within 24 hours. (Urine toxicology) 4. Medically Healthy (History, EKG, physical, labs (detailed labs are listed under screening procedures)) 5. Weight between 44 and 115 kg (physical exam) 6. Baseline systolic BP of < 150 and > 100, diastolic BP < 90 and >60 and baseline HR less than 90 (Physical exam) WITH (Assessment) 1. Males or females between 18 and 35 years old (History) 2. Fulfill DSM-V for schizophrenic illness, schizophreniform or schizoaffective disorder (History, SCID) 3. A negative urine toxicology with the exception of cannabis; in the case of a positive urine cannabis test a salivary cannabis test will be administered on the day of the PET scans to ensure subjects have not used within 24 hours. (Urine toxicology) 4. Medically Healthy (History, EKG, physical, labs (detailed labs are listed in screening procedures)) 5. Clinical Global Impression-Severity scale (CGI-S) less than or equal to 4 (moderately ill). 6. Off all medications for at least 1 week, does not wish to restart medications immediately and clinically stable while off medications. With the exception of lorazepam at a maximal dose of 2 mg QD, up to 24 h prior to the scans, and absence of injection of depot medication within the last 6 months (Interview and discussion with treating clinician) 7. Weight between 44 and 115 kg (Physical exam) 8. Baseline systolic BP of < 150 and > 100, diastolic BP < 90 and >60 and baseline HR less than 90 (Physical exam)  Pregnancy or lactation, lack of effective birth control during 15 days before the scans* (Blood or Urine pregnancy test, history) 2. Presence or positive history of serious medical or neurological illness, including low hemoglobin and seizure history. (Medical and neurological history, EKG, blood tests) 3. Any current use (within past month) of amphetamines, opiates, cocaine, sedative-hypnotics, ecstasy PCP. (History, urine toxicology) 4. Any use of cannabis beyond occasional use (i.e. more than 2 times per month) (History, saliva cannabis test) 5. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan (but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant. Dental fillings do not present a risk for MRI), as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by neuroradiologists: "Guide to MR procedures and metallic objects" Shellock, PhD, Lippincott Williams and Wilkins, NY 2001. If there is any doubt, subjects will be excluded. (Interview and history) 6. Lifetime exposure to radiation in the workplace; or participation in research protocols involving exposure to radiation within the previous year such that the total cumulative annual radiation dose (i.e., from participation in the previous research studies and this study) would exceed the radiation dose limits specified in the FDA regulations at 21 CFR 361.1, Radioactive Drugs Considered Generally Safe and Effective (i.e. annual cumulative radiation dose limit = 5 rems to gonads, blood-forming organs, lens of eye, whole body; 15 rems to other organs). (Interview and history) 7. Medical history of chronic obstructive pulmonary disease or other chronic respiratory disorders (Medical history) 8. More than one risk factor for coronary artery disease (smoking, cholesterol > 240 mg/dl, sedentary lifestyle) baseline SBP > 140 of DBP> 90) (History, physical examination and blood chemistry) 9. Positive Allen Test indicating lack of collateral flow to hand (Physical Exam) 10. Subjects with family history of a psychotic disorder, drug and alcohol Abuse/Dependence in first-degree relatives. (History) WITH (Assessment) 1. DSM-V disorder other than schizophrenia, schizophreniform or schizoaffective disorder (History, SCID) 2. Any current use (within past month) of amphetamines, opiates, cocaine, sedative-hypnotics, ecstasy PCP. (History, urine toxicology) 3. Any use of cannabis beyond occasional use (i.e. more than 2 times per month) (History, saliva cannabis test) 4. Antipsychotic medications in the last 3 weeks (6 months for depot medications) prior to the first PET scanning session. (History) 5. Pregnancy or lactation, lack of effective birth control OCP are allowed. (Pregnancy test, history) 6. Presence or positive history of severe medical or neurological illness or any cardiovascular disease, low hemoglobin, and seizure history. (Medical and neurological history, neurological exam, EKG, blood chemistry) 7. Lack of capacity to give informed consent (Interview) 8. History of significant violent or suicidal behavior (Interview and review of records) 9. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan (but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant. Dental fillings do not present a risk for MRI), as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by neuroradiologists: "Guide to MR procedures and metallic objects" Shellock, PhD, Lippincott Williams and Wilkins, NY 2001. If there is any doubt, subjects will be excluded. (Interview and history) 10. Lifetime exposure to radiation in the workplace; or participation in research protocols involving exposure to radiation within the previous year such that the total cumulative annual radiation dose (i.e., from participation in the previous research studies and this study) would exceed the radiation dose limits specified in the FDA regulations at 21 CFR 361.1, Radioactive Drugs Considered Generally Safe and Effective (i.e. annual cumulative radiation dose limit = 5 rems to gonads, blood-forming organs, lens of eye, whole body; 15 rems to other organs). (Interview and history) 11. Medical history of chronic obstructive pulmonary disease or other chronic respiratory disorders (Medical history) 12. More than one risk factor for coronary artery disease (smoking, cholesterol > 240 mg/dl, sedentary lifestyle) baseline SBP > 140 of DBP> 90) (History, physical examination and blood chemistry)