Patient description: The patient is a 53-year-old man complaining of frequent headaches, generalized bone pain and difficulty chewing that started 6 years ago and is getting worse. Examination shows bilateral swellings around the molars. The swellings have increased since his last examination. Several extraoral lesions of the head and face are detected. The swellings are non-tender and attached to the underlying bone. Further evaluation shows increased uptake of radioactive substance as well as an increase in urinary pyridinoline. The serum alkaline phosphatase is 300 IU/L (the normal range is 44- 147 IU/L). The patient's sister had the same problems. She was diagnosed with Paget's disease of bone when she was 52 years old. The diagnosis of Paget's Disease of Bone is confirmed and Bisphosphonate will be started as first-line therapy.

Clinical trial eligibility criteria: eligible ages (years): 20.0-80.0,  Lesions of the Liver Patients with a tumorous lesion in the liver observed in diagnostic imaging such as ultrasonography, etc., conducted between 1 and 35 days before administration of the investigational agent, who are scheduled to undergo a dynamic CT examination. 2. Patients between 20 and 80 years old at the time informed consent is obtained. 3. Patients weighing >= 55.6 and < 105.0 kg at the time consent is obtained and when the investigational agent is administered  Issues affecting the safety evaluation of the investigational agent: 1. Patients who will have undergone or are scheduled to undergo an examination using another contrast agent from 7 days before administration of the investigational agent up to the time follow-up examinations are performed on day 8 after administration. 2. Patients for whom there is a strong possibility that a follow-up period, which extends up until examinations are performed on day 8 after administration, would not be possible, (i.e., when it will not be possible to evaluate delayed adverse drug reactions). 3. Patients who have undergone or are scheduled to undergo surgical treatment or a therapy such as percutaneous ethanol injection therapy, percutaneous microwave coagulation therapy, radiofrequency ablation, or transcatheter arterial embolization, etc., from the time diagnostic imaging such as abdominal ultrasonography is performed up until follow-up examinations are conducted on day 8 after administration. 4. Patients who are unable to discontinue taking analgesics during the period from the morning when the investigational agent is administered until CT examinations are completed. 5. Patients who cannot stop taking biguanide antidiabetic drugs, such as metformin hydrochloride and buformin hydrochloride, for three days after study agent administration (including administration day). 6. Patients who are currently participating in another clinical study. 7. Patients who participated in another clinical study within the 6 months prior to providing informed consent to participate in this study. General concerns relating to the safety of the subject: 1. Patients in the acute stage of illness with unstable symptoms, or patients in a life-threatening condition (when it is expected that emergency treatment may be required between the time of registration and the conclusion of the follow-up period, or when the patient is not expected to survive for 3 months following administration of the investigational agent, etc.) 2. Patients with a history of hypersensitivity to iodine or iodinated contrast agents. 3. Patients with serious thyroid disease (goiter, hyperthyroidism, etc.) 4. Patients with serious cardiopathy (New York Heart Association [NYHA] functional class IV heart failure, shock, cyanosis, peripheral circulatory insufficiency, ventricular tachycardia, ventricular fibrillation, or complete atrioventricular block) 5. Patients with serious hepatopathy [symptoms of liver failure (fulminant hepatitis) such as a disturbance of consciousness corresponding to grade 3 in the for Grading Adverse Drug Reactions of Medicinal Products.] 6. Patients with moderate serious nephropathy (acute kidney failure, chronic kidney failure, hydronephrosis, nephrotic syndrome, or uremia with serum creatinine levels of 2.0 mg/dL or more, corresponding to grade 2 or above in the for Grading Adverse Drug Reactions of Medicinal Products.) 7. Patients with bronchial asthma 8. Patients with acute pancreatitis 9. Patients with macroglobulinemia 10. Patients with multiple myeloma 11. Patients with tetany 12. Patients with pheochromocytoma or who are suspected of having pheochromocytoma 13. Pregnant and potentially pregnant women, and nursing mothers 14. Patients with a history of medicine hypersensitivity 15. Patients with serious myasthenia gravis 16. Patients judged by an investigator for any other reason to be ineligible for participation as a subject in this study