Patient description: The patient is a 57-year-old man with abdominal pain and vomiting. The pain started gradually about 20 hours ago in the epigastric and periumbilical regions, radiating to his back. He drinks around 60 units of alcohol per week and smokes 22 cigarettes per day. He is healthy with no history of allergies or using any medications. His family history is positive for type 2 diabetes (his father and sister). He lives alone and has no children. The abdomen is tender and soft. His bowel sounds are normal. His heart rate is 115/min and blood pressure 110/75 mmHg. The lab results are remarkable for leukocytosis (19.5), urea of 8.5, high CRP (145), high amylase (1200) and Glc level of 15. Cross-sectional imaging was negative for obstructive pancreatitis.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Pain for Patients: 1. Patient must be greater than or equal to 18 years of age. 2. Patient must be able to comprehend English. 3. Patient must be able to provide written informed consent. 4. Patient must have had chronic widespread pain for at least one year prior to participation with an average daily intensity at least 4 out of 10. for Healthy Controls: 1. Healthy control must be greater than or equal to 18 years of age 2. Healthy control must be able to comprehend English. 3. Healthy control must be able to provide written informed consent  for patients: 1. Patient is unable to comply with study procedures or follow-up visits 2. Patient smokes more than 10 cigarettes of nicotine per week. 3. Patient uses recreational drugs. 4. Female patient consumes more than 7 half-pint beers, 7 6-oz glasses of wine or 7 1-oz shots of spirits (or equivalent) per week, and male patient consumes 14 such drinks per week. Further, patient consumes more than 5 drinks at one time. 5. Patient is pregnant or breastfeeding. 6. Patient has a major medical condition, such as kidney, liver, cardiovascular, neurological or current psychiatric condition. 7. Patient has currently or has had in the past major depression, bipolar disorder, psychosis or suicide attempts. 8. Patient has metal in his/her body which would make having an MRI scan unsafe, such as pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal workers may have. 9. Patient is uncomfortable in small closed spaces (has claustrophobia) so that he/she would feel uncomfortable in the MRI machine. 10. Patient cannot lie comfortably flat on his/her back for up to 75 minutes in the MRI scanner. 11. Patient has allergies to topical treatment. 12. Patient has a chronic pain condition other than FM. 13. Patient has taken within the last two weeks opioids. Other medications used to treat fibromyalgia at the standard doses in the community can be taken. We will not ask participants to stop any medication to participate in the study. 14. Patient has previously taken opioids for more than one month on a continual basis, within the last 6 months. 15. Patient had seen study information on clinicaltrials.gov prior to September 23, 2013. 16. Patients who decline to be audio and/or videotaped will be excluded from the qualitative interview component of the study for healthy controls: 1. Healthy control is unable to comply with study procedures or follow-up visits 2. Healthy control smokes more than 10 cigarettes of nicotine per week. 3. Healthy control uses recreational drugs. 4. Female healthy control consumes more than 7 half-pint beers, 7 6-oz glasses of wine or 7 1-oz shots of spirits (or equivalent) per week, and male healthy control consumes 14 such drinks per week. Further, healthy control consumes more than 5 drinks at one time. 5. Healthy control is pregnant or breastfeeding. 6. Healthy control has a major medical condition, such as kidney, liver, cardiovascular, neurological or current psychiatric condition. 7. Healthy control has currently or has had in the past major depression, bipolar disorder, psychosis or suicide attempts. 8. Healthy control has metal in his/her body which would make having an MRI scan unsafe, such as pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments