Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Onychomycosis Subjects must meet all of the following to be included in the study: 2. Witnessed, signed informed consent approved by Ethics Committee. 3. Male or female subjects of any race at least 18 years of age but not older than 65 years of age at the time of screening. 4. For Cohorts 1 and 2, subjects with a diagnosis of onychomycosis of at least one great toenail and with a positive KOH wet mount from that nail. For Cohort 3, subjects must have a diagnosis of onychomycosis of at least one great toenail and a positive KOH wet mount AND fungal culture from that nail. 5. Onychomycosis involving 20-60% of the affected great toenail as determined by visual inspection after the nail has been trimmed. 6. The combined thickness of the distal nail plate and the associated hyperkeratotic nail bed <3 mm. 7. Affected great toenail to be treated is capable of re-growth as documented by history or recent observation of at least 2 mm of growth. 8. Normal or not clinically significant screening safety labs  Females of childbearing potential not using a highly effective method of birth control (e.g. implants, injectables, combined oral contraceptives, some intrauterine contraceptive devices) during the study. 2. Diabetes mellitus requiring treatment other than diet and exercise. 3. Subjects with chronic moccasin type of T. pedis. 4. Subjects with a history of having failed any previous topical antifungal therapy for their onychomycosis. 5. Subjects unwilling to refrain from the use of nail cosmetics such as clear and or colored nail lacquers from the screening visit until the end of the study. 6. Subjects that have not undergone the specified washout period(s) for the following topical preparations or subjects who require the concurrent use of any of the following topical medications Topical antifungal applied to the feet (does not antifungals for treatment of T. pedis during the study): 4 weeks Anti-inflammatories, corticosteroids, topical immunomodulators: 2 weeks 7. Subjects that have not undergone the specified washout period(s) for the following systemic medications or subjects who require the concurrent use of any of the following systemic medications Corticosteroids (including intramuscular injections): 2 weeks Antifungals for treatment of onychomycosis or any systemic antifungal with known activity against dermatophytes: 24 weeks Systemic immunomodulators: 4 weeks 8. Treatment of any type for cancer within the last 6 months. 9. History of any significant internal disease. 10. Subjects with a medical history of current or past psoriasis of the skin and/or nails. 11. Concurrent lichen planus. 12. Subjects who are known to be allergic to any of the test product(s) or any components in the test product(s) or history of hypersensitivity or allergic reactions to any of the study preparations as described in the Investigator's Brochure. 13. Nail or anatomic abnormalities of the toe, e.g., genetic nail disorders, primentary disorders, onychogryphosis, trauma to the nail(s) to be treated. 14. AIDS or AIDS related complex. 15. History of street drug or alcohol abuse. 16. Any subject not able to meet the study attendance requirements. 17. Subjects who have participated in any other trial of an investigational drug or device within 60 days prior to enrollment or participation in a research study concurrent with this study