Patient description: A 3-day-old Asian female infant presents with jaundice that started a day ago. She was born at 38w3d of gestation, after an uncomplicated pregnancy. The family history is unremarkable. The baby is breastfed. Vital signs are reported as: axillary temperature: 36.3°C, heart rate: 154 beats/min, respiratory rate: 37 breaths/min, and blood pressure: 65/33 mm Hg. Her weight is 3.2 kg, length is 53 cm, and head circumference 36 cm. Her sclera are yellow and her body is icteric. No murmurs or any other abnormalities are detected in the heart and lung auscultation. Her liver and spleen are normal on palpation. Laboratory results are as follows: Serum total bilirubin: 21.02 mg/dL Direct bilirubin of 2.04 mg/dL AST: 37 U/L ALT: 20 U/L GGT: 745 U/L Alkaline phosphatase: 531 U/L Creatinine: 0.3 mg/dL Urea: 29 mg/dL Na: 147 mEq/L K: 4.5 mEq/L CRP: 3 mg/L Complete blood cell count within the normal range. She is diagnosed with uncomplicated neonatal jaundice that may require phototherapy.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Pre-eclampsia A subject with a diagnosis of severe preeclampsia will be eligible for if she meets the following 1. In the opinion of the investigator delivery is considered to be probably required within a 72 hour time period and, therefore, corticosteroid administration is needed. 2. Meets both American College of Obstetricians (ACOG) for preeclampsia (modified to limit selection to patients with the required severity) A systolic blood pressure of 140 mm Hg or higher or a diastolic blood pressure of 90 mm Hg or higher occurring after 20 weeks of gestation in a woman whose blood pressure has previously been normal Proteinuria, with excretion of 0.3 g or more of protein in a 24-hour urine specimen or a urine dipstick reading of 1+ or more. 3. Meets at least one of the following ACOG for severe preeclampsia (modified to limit selection to patients with the required severity) . Proteinuria of 5 grams or higher in a 24-hour specimen or 3+ or greater on 2 random urine samples collected at least 4 hours apart A systolic blood pressure of 160 mm Hg or higher or a diastolic blood pressure of 110 mm Hg or higher on two occasions six or more hours apart in a pregnant woman who is on bed rest Oliguria, with excretion of less than 500 ml of urine in 24 hours or average of ≤ 25 ml/hour over a 3 hour period Pulmonary edema Impairment of liver function [AST(SGOT) > 72 U/L or ALT(SGPT) > 72 U/L or LDH > 600 U/L or Total Bilirubin >1.2 mg/DL)] Visual or cerebral disturbances Decreased platelet count (≥50,000/mm3 and ≤ 100,000/mm3). 4. Has a fetal gestational age of 23 5/7 to 34 weeks  Is in need of immediate delivery as soon as clinically appropriate 2. Eclampsia 3. Significant antecedent obstetrical problems which may interfere with study assessments or safe participation in the study 4. Evidence of non-reassuring fetal well being 5. Evidence of lethal fetal anomaly 6. Antecedent hypertension (hypertension secondary to preeclampsia, treated or untreated is allowed) 7. Antecedent renal, hepatic, or autoimmune disease 8. Medical or psychiatric disorder which is unstable or which might interfere with study assessments or safe participation in the study 9. Evidence on medical history/evaluation of use of or need for digitalis-like products currently or in the future 10. History of a severe allergic reaction to previous medication, severe asthma, or atopy. (Patients with a history of allergic reactions to antibiotics, papain, chymopapain, or other papaya extracts may be more susceptible to allergic reactions to Digibind®) 11. Prior use of antibodies/FAB fragments from sheep (e.g. Digibind®, DigiFab, CroFab) 12. Serum creatinine ≥ 1.5 mg/dl 13. Platelet count <50,000/mm3 14. Patient intends to breast feed and does not agree to wait for a minimum of seven days after the last Digibind® dose (a breast pump would be used for this seven day period) 15. Inability to understand and provide informed consent