semaj83/ctmatch_classification huggingface dataset:
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Sickle Cell Disease Sickle Cell Anemia SCD Patients must have one of the following inherited hemoglobin gene disorders Hemoglobin SS Hemoglobin SC Hemoglobin S-Beta-zero-Thalassemia or Hemoglobin S-Beta-plus Thalassemia Disease Morbidity For matched sibling donor grafts (low-risk e.g., matched sibling donor), patients must have evidence for morbid disease that has failed conventional therapy 2 or more painful episode/year (requiring Emergency Department or inpatient care) x 3 years or 2 or more diagnoses of Acute Chest Syndrome within 5 years, or 2-year mortality 5-10%  eGFR <50 ml/min ≥2.0 liter-per-minute pm home oxygen requirement An estimated Left Ventricular Ejection Fraction ≤40% (echo or MUGA) Hepatic cirrhosis (Biopsy Proven) HIV positive, ineligible because of the increased risk of lethal infections when treated with marrow suppressive therapy. Appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated Red cell alloimmunization to a degree that precludes extended transfusion Patients with uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements Pregnant or breastfeeding women are excluded from this study because the immunomodulatory treatment, preparative regimen, and anti-GVH therapy contain agents with the potential for teratogenic or abortifacient effects. Further, this treatment, if indicated, is for a chronic condition, and can be delayed until the pregnancy has been successfully concluded. Because there is an unknown, but potential risk for adverse events in nursing infants secondary to treatment of the mother with, breastfeeding should be discontinued if the mother is treated with these agents. These potential risks may also apply to other agents used in this study Subjects must not have evidence for impaired liver function due to iron overload, +/ hepatitis. Patients will be evaluated by hepatology if ferritin >1500, if history of hepatitis, or ALT/ALP are >1.5 X ULN
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 0.0-0.014,  Heart Murmurs Mitral Valve Prolapse Systolic Murmurs any premature baby or newborn parental approval for study participation
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 16.0-999.0,  Autoimmune Hemolytic Anemia Patients diagnosed with primary warm Autoimmune Hemolytic Anemia Secondary Autoimmune Hemolytic Anemia (infections, hemopathy, systemic diseases) Naive to any treatment for hemolytic anemia or in relapse Older than 16 years of age Able to understand written and spoken French who have provided written informed consent • for Persons without an auto-immune disease, or cancer or an active infection Older than 16 years of age Able to understand written and spoken French  Cold agglutinin disease Pregnant women Persons not covered by national health insurance Non-Inclusion controls Persons treated with corticoids or immunosuppressants Pregnant women Persons not covered by national health insurance
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 0.654-0.788,  Anemia Iron Deficiency Neonatal Jaundice Late preterm or term pregnancy (gestational age 34 to 41 weeks) Vaginal delivery  Serious congenital malformation, syndrome or other congenital disease that can affect the outcome measures
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Anemia Critical Illness Hospitalized for 5 Days or More Hospitalized man/woman in reanimation unit for at least 5 days Age ≥ 18 years old Patient having an anaemia such as defined by the WHO (World Health Organization) (for man: Hemoglobin < 13 g/dl, for woman: Hemoglobin < 12 g/dl) Signed inform consent by the patient or a close person Subject affiliated to a national health insurance  Known iron metabolism pathology (such as primitive or secondary hemochromatosis, …) Chronic anaemia (Hemoglobin ≤ 10 g/dl for more than 3 months) Current chemotherapy Patient having an organ transplant Expected survival < 28 days post Intensive Care Unit discharge Pregnancy Patient deprived of freedom, by judicial or administrative order Major protected by the law Contra-indication to the injectable iron treatment (allergy to ferric carboxymaltose, infection derivates (bacteriamy < 48 hours) untreated) Non speaking French patient, or patient unable to answer a questionnaire because of any neurologic disorder (stroke, brain trauma….)
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Autoimmune Hemolytic Anemia Adults (18 years old) wAHAI defined by the presence of hemolysis and positive coombs test (IgG +/-C3) Absence of infection or other hematologic disease wAHAI not responding to conventional steroids despite a dose over 10 mg No treatment with rituximab for a minimum of 6 months Signed informed consent form  Less than 18 years old Cold AHAI IL2 allergy Chemiotherapy or immunosuppressive treatment Treatment with rituximab for less than 6 months Neoplasia or hematologic malignancy Aplastic anemia Neutropenia ≤ 1000 mm3 Infection Hepatitis B or C
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 0.083-0.25,  Biliary Atresia persistent yellow skin or sclera, pale stool (in severe cases, clay-like), and hepatomegaly increased serum bilirubin (progressively or no decline after increase), increased total bilirubin (TBil) dominated by increased direct bilirubin (DBil) (>60%) elevated liver enzymes ultrasound confirmation of poor gallbladder filling and signs of liver fibrosis with radionuclide imaging confirmation of obstructed biliary excretion  concomitant cardiovascular or abdominal organ malformations
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 0.0-18.0,  Heart Murmurs Mitral Valve Prolapse Systolic Murmurs outpatient parental approval for study participation
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 12.0-17.0,  Cancer Teenagers at the ages 12-17 Four or five (dependent on their overall plan of medical treatment) consecutive courses of chemotherapy administrated at the involved child cancer units and (administered) over a period of minimum 24 hours incl. hydration with assumed moderate to severe nausea and vomiting The specific type of chemotherapy may vary across the four/five consecutive courses but shall one of the following moderate and/or highly emetogenic types of chemotherapy Moderate emetogenic chemotherapy Carboplatin Cyclophosphamide <1500 mg/m2 Cytarabine >1 g/m2 Daunorubicin Doxorubicin Epirubicin  Previous and/or acute psychiatric diagnosis Cognitive and mental deficits or impaired functioning
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Nicotine Dependence Have no known serious medical conditions Are 18-65 years old Smoke an average of at least 10 cigarettes per day Have smoked at least one cumulative year Have an expired air CO reading of at least 10ppm Are able to read and understand English Potential subjects must agree to use acceptable contraception during their participation in this study. Potential subjects must agree to avoid the following during their participation in this study Participation in any other nicotine-related modification strategy outside of this protocol Use of tobacco products other than cigarettes, including pipe tobacco, cigars, snuff, and chewing tobacco Use of e-cigarettes other than the ones provided during the study  Intent to quit smoking with FDA approved pharmaceutical products within the next 90 days Hypertension (systolic >160 mm Hg, diastolic >100 mm Hg. Participants with a history of hypertension may, however, be allowed to participate in the study if the study physician or physician assistant determines that the condition is stable, controlled by medication, and in no way jeopardizes the individual's safety Coronary heart disease Lifetime history of heart attack Clinically significant cardiac rhythm disorder (irregular heart rhythm) Chest pains (unless history, exam, and ECG clearly indicate a non-cardiac source) Clinically significant cardiac (heart) disorder (including but not limited to valvular heart disease, heart murmur, heart failure) Clinically significant liver or kidney disorder (except kidney stones, gallstones) Clinically significant gastrointestinal problems or disease Active ulcer in the past 30 days
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Warm Antibody Autoimmune Hemolytic Anemia Subject must have had a diagnosis of primary or secondary warm antibody AIHA Must have previously received at least 1 prior treatment regimen for AIHA and have evidence of relapse  Subject with cold antibody AIHA, cold agglutinin syndrome, mixed type AIHA, or paroxysmal cold hemoglobinuria Subject with a platelet count of < 100,000/μL Subject has AIHA secondary to autoimmune disease, including systemic lupus erythematosis (SLE), or lymphoid malignancy and the underlying disease is not stable or is not well-controlled on current therapy Subject has uncontrolled or poorly controlled hypertension, defined as systolic blood pressure ≥ 140 mmHg, or diastolic blood pressure ≥ 90 mmHg
Patient description: A 15 yo girl accompanied by her mother is referred for evaluation by the school. The girl has more than expected absences in the last three month, appears to be constantly tired and sleepy in class. Her mother assures the girl is well fed, and getting the proper sleep at night but admits the girls tires easily when they go out on weekend hikes. Physical examination: BP: 90/60. HR 130/min the only remarkable findings are extremely pale skin and mucosae. Grade 3/6 systolic murmur. Lab tests report Hb: 4.2 g/dL, MCV 61.8 fL, serum iron < 1.8 umol/L and ferritin of 2 ng/mL. Fecal occult blood is negative.

Clinical trial eligibility criteria: eligible ages (years): 18.0-120.0,  Atypical Hemolytic Uremic Syndrome Thrombotic Thrombocytopenic Purpura Microparticles Microangiopathic Hemolytic Anemia Patients with MAHA, TTP, and/or aHUS  Prisoners
Patient description: A previously healthy 8-year-old boy presents with a complaint of right lower extremity pain and fever. He reports limping for the past two days. The parents report no previous trauma, but do remember a tick bite during a summer visit to Maryland several months ago. They do not remember observing erythema migrans. On examination, the right knee is tender and swollen. Peripheral WBC count and SRP are slightly elevated.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Lyme Disease Tick-Borne Diseases Ferry passengers traveling to Nantucket Island  Foreign (non-U.S.) residence
Patient description: A previously healthy 8-year-old boy presents with a complaint of right lower extremity pain and fever. He reports limping for the past two days. The parents report no previous trauma, but do remember a tick bite during a summer visit to Maryland several months ago. They do not remember observing erythema migrans. On examination, the right knee is tender and swollen. Peripheral WBC count and SRP are slightly elevated.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Lyme Disease You may be eligible for this study if you Are between 18 and 65 years of age Are a resident of Long Island or greater NY metropolitan area Are fluent in English Have a history of Lyme Disease Have completed antibiotic treatment for Lyme Disease 6 or more months before starting the study Have severe fatigue Are not pregnant or planning to be pregnant  You will not be eligible for this study if you Have or have had major medical, neurologic, or psychiatric disorder Have had prior chronic pain, fatigue, or recurrent severe headaches before the onset of Lyme Disease Have had Fibromyalgia Syndrome Have a history of sleep apnea, narcolepsy, or other serious sleep disorder Have a learning disability Have had head trauma requiring hospitalization Have symptomatic gallbladder disease Are anemic Abuse alcohol or illicit drugs
Patient description: A previously healthy 8-year-old boy presents with a complaint of right lower extremity pain and fever. He reports limping for the past two days. The parents report no previous trauma, but do remember a tick bite during a summer visit to Maryland several months ago. They do not remember observing erythema migrans. On examination, the right knee is tender and swollen. Peripheral WBC count and SRP are slightly elevated.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Lyme Disease You may be eligible for this study if you Are at least 18 years of age Are seronegative for antibodies against B. burgdorferi antigens by Western Blot at enrollment Have documented history of acute Lyme disease Have had a rash (erythema migrans) that resembles a bullseye. This skin aberration usually occurs after a tick bite in late spring, summer, or early fall and is sometimes accompanied by fatigue, fever, headache, mild stiff neck, arthralgia or myalgia Have had one or more clinical features typical of Lyme disease acquired in the United States (see technical summary) Have had one or more of the following symptoms and conditions that have persisted for at least 6 months (but less than 12 years) and are not attributable to another cause or condition: a) widespread musculoskeletal pain and fatigue that began coincident with or within 6 months following initial infection with B. burgdorferi. b) certain neurologic symptoms including memory impairment and nerve pain, beginning within 6 months following initial infection with B. burgdorferi Have had a physician-documented history of prior antibiotic treatment with a currently recommended antibiotic regimen  You will not be eligible for this study if you Have previously enrolled in this study Are pregnant, lactating, or unable to use birth control measures during the treatment period of this study Are taking chronic medication that could interfere with evaluation of symptoms Are taking or have taken various medications that could interfere with the evaluation of symptoms (see technical summary) Are hypersensitive to ceftriaxone or doxycycline Have active inflammatory synovitis Have another disease that could account for symptoms of acute Lyme disease Have another serious or active infection Are unable to tolerate an IV
Patient description: A previously healthy 8-year-old boy presents with a complaint of right lower extremity pain and fever. He reports limping for the past two days. The parents report no previous trauma, but do remember a tick bite during a summer visit to Maryland several months ago. They do not remember observing erythema migrans. On examination, the right knee is tender and swollen. Peripheral WBC count and SRP are slightly elevated.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Erythema Migrans Lesions Erythema Migrans Patients Age greater than or equal to 18 years Diagnosis of EM an expanding annular lesion, at least 5 cm in diameter on a person with a history of exposure to the disease Exposure is defined as having been (less than or equal to 30 days before onset of EM) in wooded, brushy, or grassy areas (i.e., potential tick habitats) in an area in which Lyme disease is endemic A history of tick bite is not required The area of the erythema migrans lesion is suitable for biopsy. This excludes biopsies on the face, neck, scalp, and over the tibia Not know to be positive for RPR, HIV, HBsAg or HCV Able to give consent Healthy Volunteers  Patients Antibiotic therapy for the current episode of Lyme disease Oral corticosteroids within the past 2 weeks History of severe skin disease (such as psoriasis, atopic dermatitis) in the last year Diagnosis of diabetes, active cancer, or autoimmune diseases Investigational drugs in the past month History of forming large thick scars after skin injuries or surgery History of excessive bleeding after cuts or procedures or on anticoagulation Use of steroid cream/ointment at the rash Healthy Volunteers
Patient description: A previously healthy 8-year-old boy presents with a complaint of right lower extremity pain and fever. He reports limping for the past two days. The parents report no previous trauma, but do remember a tick bite during a summer visit to Maryland several months ago. They do not remember observing erythema migrans. On examination, the right knee is tender and swollen. Peripheral WBC count and SRP are slightly elevated.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Lyme Neuroborreliosis Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled Intrathecal production of borrelia antibodies White cell count in cerebrospinal fluid (CSF) > 5/mm3 Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval Verified acrodermatitis chronica atrophicans  Allergy to the contents in the medication, or earlier type I reaction to penicillin Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days Pregnancy or breastfeeding Age < 18 years