semaj83/ctmatch_classification huggingface dataset:
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 20.0-999.0,  Neoplasms, Gastrointestinal Tract Specific Information regarding warnings, precautions, contraindications, adverse events, and other pertinent information on the investigational product that may impact subject is provided in the Investigator's Brochure (IB) Pilot Part Subjects eligible for enrollment in the Pilot Part of the study must meet all of the following Signed informed consent Male or female; ≥ 20 years (at the time of giving consent) Any histologically or cytologically confirmed gastric carcinoma independent of tumor ErbB2 status Subjects who have received one prior regimen for gastric carcinoma and developed disease progression or recurrence. The regimen must have contained 5-fluoropyrimidine and/or cisplatin Left ventricular ejection fraction (LVEF) within institutional range of normal as measured by echocardiogram (ECHO). Multigated acquisition (MUGA) scans will be accepted in cases where an echocardiogram cannot be performed or is inconclusive (LVEF of ≥50% required if normal range of LVEF is not provided by institution) Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 Able to swallow and retain oral medication Women and men with potential to have children must be willing to practice acceptable methods of birth control during the study  Subjects meeting any of the following must not be enrolled in the study Pregnant or lactating female at anytime during the study Planned concurrent anti-cancer therapy (chemotherapy, radiotherapy, immunotherapy, biologic therapy, hormonal therapy) while taking investigational treatment Unresolved or unstable, serious toxicity from prior cancer treatment (any toxicities greater than grade 2) Peripheral neuropathy of Grade 2 or greater Malabsorption syndrome, disease significantly affecting gastrointestinal function. Subjects with ulcerative colitis and Crohn's disease are also excluded History of other malignancy. However, subjects who have been disease-free for 5 years, or subjects with a history of completely resected non-melanoma skin cancer or successfully treated in situ carcinoma, are eligible Concurrent disease or condition that would make the subject inappropriate for study participation or any serious medical disorder that would interfere with the subject's safety Life threatening infection Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Congenital Hypothyroidism Patients with congenital hypothyroidism due to thyroglobulin defective synthesis  Patients with another disease
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hypothyroidism Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis Healthy controls matched regarding sex, age and body mass index  Pregnancy, breastfeeding
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 23.0-73.0,  Iron Deficiency Anemia Subclinical Hypothyroidism Clinical diagnosis and laboratory confirmation of iron deficiency anemia and subclinical hypothyroidism Must be able to swallow tablets  Multifactorial anemia or anemia due to other reasons Iron deficiency anemia requiring urgent intervention cardiac ischemia, severe anemia, GI or GU losses due to malignancy and or acute/subacute big loses by respiratory, Gİ, GU, etc. system Prior thyroid disorder and/or treatment history Presence of any other co-morbid disease like renal insufficiency/ failure, coronary heart disease, hypertension, diabetes mellitus, any endocrine system disease other than subclinical hypothyroidism
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 20.0-90.0,  Thyroid Nodule age between 20 to 90 years old Benign nodular goiter diagnosed with thyroid echo and fine-needle aspiration cytology  Age younger than 20 or older than 90 years old Pregnancy Allergy to eltroxin Taking other drugs which will have drug interaction with eltroxin patients with cardiovascular disease, hypertension, gastrointestinal disease
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 0.0-0.077,  Hypothyroxinemia Birth weight: less than 1500g Gestation: 22 weeks 0 day ≤ Serum free thyroxine level lower than 0.8 ng/dl Serum thyrotropin lower than 10 μU/ml Age of between 2 and 4 weeks after birth Informed consent  any known thyroid disease in mother
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 2.0-6.0,  Gram Positive Infection Concurrent Antibiotic Treatment Written parental (or appropriate legal representative) informed consent prior to any study-related procedure not part of normal medical care Male or female between the ages of 2 and 6 years old, inclusive Able to comply with the protocol for the duration of the study Clinically stable with no evidence of hemodynamic instability (defined as a requirement for pharmacological intervention to manage blood pressure) in the 72 hour window prior to enrollment, and no history or evidence of renal or hepatic compromise Suspected or diagnosed Gram-positive infection for which the subject is receiving standard antibiotic therapy A calculated creatinine clearance rate (CLcr) ≥ 80 ml/min/1.73m2 as determined by the Schwartz equation at baseline Creatine phosphokinase (CPK) levels less than 2X ULN (upper limit of normal) at baseline Presence of two patent intravenous lines (or comparable means of venous access) prior to dosing on Study Day 1  Investigational drug use (including daptomycin) or participation in any experimental procedure in the 30 days preceding study entry Known allergy/ hypersensitivity to daptomycin History of clinically significant cardiovascular, renal, hepatic, pulmonary (well-controlled asthma is acceptable), gastrointestinal, endocrine, hematologic, autoimmune disease or primary immune deficiency Pneumonia as sole Gram-positive infection being treated with standard antibiotics Subjects with clinically significant abnormal laboratory test results [including electrocardiograms (ECGs)], as determined by Investigator Administration of rifampin within 7 days of study drug administration Body mass index (BMI) that is outside of the 5th to 95th percentile Subjects in whom collection of the required blood volume would put them at risk of hemodynamic disturbance (at the discretion of Investigator) History of or current clinically significant (at the discretion of the Investigator) muscular disease, nervous system or seizure disorder Administration of intramuscular injection between baseline and study drug administration or expected intramuscular injection within 24 hours following dosing
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-48.0,  Hypothyroidism Premenopausal women with overt primary hypothyroidism (reduced T4 concentration accompanied by increased TSH concentration at the time of initial diagnosis) who did not receive thyroid hormones  Peri and postmenopause Pregnancy Major comorbidity Use of drugs that affect metabolism or bioavailability of thyroid hormones preparations
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 17.0-44.0,  Hypothyroidism TSH value >98th centile in early pregnancy  Women with known hypothyroidism
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Schizophrenia Schizoaffective Disorder Weight Gain non-diabetic schizophrenic or schizoaffective currently prescribed olanzapine or ziprasidone 80 y.o  <18 or >80 years of age diabetic not schizophrenic or schizoaffective not currently prescribed olanzapine or ziprasidone
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Depression Age 18 Written informed consent Current MDD according to the fourth version of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) Recently started to receive or about to start receiving treatment for MDD Quick Inventory of Depressive Symptomatology Clinician-Rated (QIDS-C) and QIDS-IVR scores equal or greater than 10 at baseline visit  Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician. These patients will be immediately referred to appropriate clinical treatment History or current diagnosis of the following DSM-IV psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, patients with substance dependence disorders, other than alcohol, active within the last 12 months History or current diagnosis of dementia Diagnosis or history of hypothyroidism
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Arthroplasty, Replacement, Knee Scheduled for total knee replacement or revision of total knee replacement Agree to have a regional technique including neuraxial analgesia for post-operative analgesia Be 18 to 70 years old Classified as ASA score I-III  Allergic to morphine Allergic to local anesthetics Been on opioids for more than 4 weeks Not willing to be randomized On anticoagulation medications that prevent placement of epidural Sensitive to effects of neuraxial opioids BMI>35 Severe COPD Obstructive sleep apnea (OSA, see below). Each patient will be asked the questions below to determine their risk for OSA (STOP questionnaire). Patients who answer yes to 3 or more of the major of the STOP questionnaire and have one of the minor will be excluded from the study STOP Questionnaire for OSA
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 4.0-18.0,  Chronic Constipation Less than 2 per week defecation Fecal incontinence Retentive behavior Pain at defecation and Hard stools  Medication use (calcium, antacid, diuretic and hematinic) Organic causes (spina bifid, hypothyroidism, hirschusprung disease, developmental delay neuropsychomotor, kidney disease and metabolic diseases)
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 60.0-95.0,  Subclinical Hypothyroidism TSH between 4 and 10 mUI/L inclusive  Known and treatment of thyroideal disease Arrythmia Anticoagulant treatment Dementia Disease leading to dementia (acv, LIVER....)
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Fibromyalgia Female volunteers who have been diagnosed with fibromyalgia by a rheumatologist Overall body pain average score ≥ 4 Age range: 18 to 65 years old You must be on stable doses of anyone of these fibromyalgia-related medications for at least 4 weeks: cyclobenzaprine, tramadol, gabapentin, pregabalin, amitriptyline, nortriptyline, trazodone, sertraline, fluoxetine, paxil, remeron, venlafaxine and duloxetine Willingness to restrict any change (add or switch or change in the dose) of any fibromyalgia-related medication for 12 weeks  Volunteers who have long-standing history of diabetes (> 2 years), or have been diagnosed with any type of peripheral neuropathy Have a prior history of myocardial infarction (heart attack) or unstable angina or other heart arrhythmias Have been diagnosed with multiple sclerosis or any other demyelinating disorder Have planned to undergo an elective surgery over the next 12 weeks Have other major rheumatic conditions (i.e. rheumatoid arthritis, systemic lupus erythematosus, scleroderma and other connective tissue disease) Are currently pregnant or actively trying to become pregnant
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 12.0-65.0,  Vitiligo Any Vitiligo patient (age 12 years and above) with non-segmental Vitiligo Body surface area (BSA) involvement ≥ 3%  Unable to consent Any topical, systemic or phototherapy for Vitiligo in the previous 2 months Pregnancy, breast feeding Liver or kidney disease Epilepsy Bleeding disorder or anticoagulant treatment
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Anemia years or older Diagnosis of low or intermediate-1 risk Myelodysplastic (MDS) with any chromosome karyotype except del 5q[31] Anemia that requires red blood cell transfusions Resistant to erythropoiesis stimulating agents (ESAs) or blood erythropoietin level > 500 mU/mL Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 2 Must agree to follow pregnancy precautions as required by the protocol Must agree to receive counseling related to teratogenic and other risks of lenalidomide Must agree not to donate blood or semen Must be willing to consent to two or more bone marrow aspirate procedures to be completed during study  Subjects previously receiving immunomodulating or immunosuppressive agents, or epigenetic or deoxyribonucleic acid (DNA) modulation agents Allergic reaction to thalidomide Renal insufficiency creatinine clearance (CrC1)<40 mL/min by Cockcroft-Gault method) Prior history of cancer, other than MDS, unless the subject has been free of the disease for ≥ 5 years. (Basal cell carcinoma of the skin, carcinoma in situ of the cervix, or stage Tumor (T) 1a or T1b prostate cancer is allowed) Absolute neutrophil count (ANC) < 500/uL Platelets < 50,000/uL Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3X upper limit of normal Uncontrolled hyperthyroidism or hypothyroidism Significant neuropathy Prior stem cell transplantation
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Neuropathy Men and women, ages of 18 or greater Documented evidence of HIV-1 infection Documented diagnosis of HIV-associated Distal Symmetrical Polyneuropathy (DSP) with subjective sensory symptom of pain Pain starts in the feet  Subject has untreated vitamin B12 deficiency (serum B12 level <200 pg/ml) or if treated B12 deficiency -treatment is less than 6 months of B12 supplementation (injection or intranasal B12) prior to screening Diabetes mellitus requiring regular medical treatment (other than diet and exercise) or HbA1C >6.9 Subjects with peripheral neuropathic pain that is not associated with HIV infection; including subjects with conditions such as: Post Herpetic Neuralgia (PHN), Diabetic Peripheral Neuropathy (DPN), familial neuropathies; compression related neuropathy, radicular pain, other infection related neuropathies (eg, leprosy); neuropathy related to: metabolic abnormalities; nutritional factors; vascular insults; inflammation; autoimmune disease; and malignancy
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 21.0-85.0,  Cerebral Stroke Ischemic or hemorrhagic stroke greater than 3 months prior Residual hemiparetic gait with observable asymmetry in the gait pattern Women or men aged 21 to 85 years Completed all conventional physical therapy Adequate language and neurocognitive function to participate in training, testing, and to give informed consent Minimal ankle flexion in either direction (dorsi or plantar-)  MMSE score < 23 (9th grade education or more) or MMSE score < 17 (8th grade education or less) CES-D score > 16 Clinical history of orthopedic, chronic pain or severe neuromuscular disorders restricting participation in a short term ankle movement training paradigm Severe or global receptive aphasia which confounds reliable testing and training Women of child-bearing potential, if there is any self-reported chance that they may be pregnant
Patient description: A 56-year old Caucasian female complains of being markedly more sensitive to the cold than most people. She also gets tired easily, has decreased appetite, and has recently tried home remedies for her constipation. Physical examination reveals hyporeflexia with delayed relaxation of knee and ankle reflexes, and very dry skin. She moves and talks slowly.

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Acute Myeloid Leukemia Diagnosis of one of the following Newly diagnosed de novo acute myeloid leukemia (AML) AML secondary to myelodysplastic syndromes (MDS) AML secondary to exposure to leukemogenic therapy or agents with primary malignancy in remission for at least 2 years Bone marrow blasts >30% Age ≥ 65 years Easter Cooperative Oncology Group (ECOG) 0-2  Previous cytotoxic or biologic treatment for AML (except hydroxyurea) Previous treatment with azacitidine, decitabine or cytarabine Prior use of targeted therapy agents (e.g., FLT3 inhibitors, other kinase inhibitors) AML French American British subtype (FAB M3) AML associated with inv(16), t(8;21), t(16;16), t(15:17), or t(9;22) karyotypes Prior bone marrow or stem cell transplantation Candidate for allogeneic bone marrow or stem cell transplant Diagnosis of malignant disease within the previous 12 months (excluding base cell carcinoma, "in-situ" carcinoma of the cervix or breast or other local malignancy excised or irradiated with a high probability of cure) Malignant hepatic tumors Uncontrolled systemic infection