semaj83/ctmatch_classification huggingface dataset:
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-75.0,  Parkinson Disease General 1. Age 30-75 years old 2. Signed written informed consent 3. Gender: Both (Male and Female) 4. Pupillary reflex to light. 5. Clear ocular media Patients' Patients with clinical presentations of the neurodegenerative forms of parkinsonism (bradykinesia, extrapyramidal rigidity, tremor, postural instability and gait disturbance) including: idiopathic Parkinson disease (PD), Lewy body disease (LBD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD) and secondary parkinsonisms. Control group Normal eye examination 2. Best-corrected visual acuity (BCVA) of 20/20 3. Normal color vision test (Farnsworth/Lanthon D-15 Test) 4. No present ocular disease 5. No past ocular disease or surgery within last 6 months 6. No use of any topical or systemic medications that could adversely influence efferent pupil movements 7. Normal 24-2 Humphrey visual field and Short duration (≤10 minutes) Minimal fixation losses, False positive errors and False negative errors (less than 30% for each one of reliability indices)  Diagnosis of dementia. 2. Cognitive decline that may impair obtaining informed consent. 3. Tremor or dyskinesia that could interfere with ophthalmic evaluation 4. History of past (last 3 months) or present ocular disease or ocular surgery 5. Use of any topical or systemic medications that could adversely influence pupillary reflex 6. Psychiatric illness, active psychosis. 7. Previous neurosurgical interventions, including stereotactic neurosurgical procedures. 8. Past or current strokes or brain injury and other brain disorders (except PD/parkinsonism for patient group) 9. Anti-dopaminergic drugs. 10. Intolerance to gonioscopy, slit lamp examination, Goldmann applanation tomometry or other schedule study procedure. 11. Visual media opacity including cloudy corneas. 12. Any condition preventing accurate measurement or examination of the pupil
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 40.0-79.0,  Parkinson Disease Age: 40-79 y Idiopathic Parkinson's Disease Diagnosis Disease Stage: Hoehn and Yahr stage 2-3 Patient requires a minimum of 3 doses of levodopa daily Willingness to be videotaped  Dementia or Montreal Cognitive Assessment score <24 Parkinson's Disease psychosis Ear trauma Facial pain Traumatic Brain Injury or clinical history of stroke Metal implants above the shoulders History of myocardial infarction or arrhythmia, bradycardia Active respiratory disorder Alcohol or substance use disorders History of Deep Brain Stimulation (DBS) or other brain surgery
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Hypercholesterolemia Key 1. Body mass index (BMI) between 18.0 and 40.0 2. Stable (>4 weeks prior to the Screening Visit) dose of statin therapy with or without ezetimibe 3. Fasting low-density lipoprotein cholesterol (LDL-C): ≥100 mg/dL for those without cardiovascular disease, or ≥70 mg/dL for those with cardiovascular disease. 4. Fasting triglycerides (TGs) <400 mg/dL Key  Women who are pregnant, nursing or breast feeding 2. Currently prescribed a lipid lowering agent other than a statin or ezetimibe. 3. Clinically significant disorder or laboratory abnormality that could contraindicate the administration of study drug, affect compliance, interfere with study evaluations, or confound the interpretation of study results
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease ≥ 18 years of age Diagnosis of Idiopathic Parkinson's Disease（IPD）based on the Movement Disorder Society clinical diagnostic for Parkinson's Disease Subjective feeling that Motor Symptoms（MS）of Parkinson's Disease （PD） were affected by seasonal variation (i.e., MS were more severe in winter than in summer) and improved after HTB No change in the patient's PD medication regimen during the study  Symptomatic bradycardia, severe postural hypotension, symptomatic coronary insufficiency, severe organic heart damage, severe cerebrovascular disease, and active psychosis Dementia (Mini-Mental State Examination (MMSE) < 24 and Montreal Cognitive Assessment (MOCA) < 26) Failure to cooperate with the study requirements and poor compliance
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 20.0-39.0,  Hand Injuries and Disorders only right-handed individuals male and female have preserved cognitive functions absence of neurological disorder who present minimum grip strength by the Jamar ® dynamometer, in the age group of 20-29 years men 45.08 ± 0.67 kg and women of 27.2 ± 0.46 kg, who present minimum grip strength by the dynamometer Jamar ®, aged 30 to 39 years old men 46.05 ± 0.47 kg and women 28.0 ± 0.39 kg, using the mean minus the standard deviation  Injury to upper limbs such as amputation, recent surgery (6 months), fractures, bruising, pain and musculoskeletal disorders Do not accept to participate in the survey
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Ideopathic Parkinson's Disease Disease in the moderate-severe phase (Hoehn & Yahr ≥ 2 en Off) Motor fluctuations (with at least 2h/day in Off) Agree to participate voluntarily and will sign a written consent form  Incapable of walking independently or H&Y=5 Participating in another clinical trial Patients with acute intercurrent disease Psychiatric or cognitive disorders that prevent collaboration (MMSE <24)
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Parkinson Parkinson disease patients on Hoehn and Yahr 3-4  Mini-Mental State Examination < 24 Fluent aphasic patients Apraxia Neglect major neuropsychiatric disorders
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 20.0-89.0,  Cardiovascular Diseases Ischaemic Heart Disease Clinically suitable for stress echocardiography examination  None
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 20.0-75.0,  Freezing of Gait Parkinson Disease Patients' age between 20 and 75 years old 2. Idiopathic PD with cardinal motor impairment (bradykinesia, rigidity, tremor and postural instability 3. Advanced PD as determined by Hoehn and Yahr stage or UPDRS part III motor score 4. Levodopa responsive 5. Disabling Parkinson's symptoms or drug side effects (dyskinesia, motor fluctuation or disabling "off"period) despite the best medical therapy. 6. Willingness and ability to cooperate during conscious operative and experimental procedure. 7. Normal MRI  Non-idiopathic parkinsonism or "Parkinson's plus syndrome" 2. Impaired cognitive dysfunction (MMSE<26) 3. Moderate to severe depression (BDI≧30) 4. Depression (BDI≧30), or psychiatric disorder 5. Structure lesion such as stroke, tumor or severe brain atrophy revealed by MRI 6. Major medical disorders, such as hematological, heart disease or malignancy 7. Significant medical, surgical or neurological co-morbidities contraindicating DBS surgery or stimulation
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Essential Tremor Patients diagnosed with ET by the Consensus Statement on the Classification of Tremors,From the Task Force on Tremor of the International Parkinson and Movement Disorder Society  Lack of capacity to consent to participate in the project
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 60.0-999.0,  Ageing Male or female aged at least 60 years Must be able to provide informed consent Must be able to complete the Cognitive Tests/Questionnaires, Health Questionnaires by themselves and be familiar with using an ipad/tablet  Currently taking part in an interventional study Living with or related to any member of the research team Have a diagnosis of Dementia, Parkinson's Disease, Alzheimer's Disease, Creutzfeldt-Jakob disease (CJD), Picks Disease Bipolar Disorder Obsessive Compulsive Disorder Untreated current clinical depression Have irreversible brain injury Have had a stroke Have epilepsy Take more than a daily dose of probiotics
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 20.0-999.0,  Cardiovascular Diseases Are at least 20 years old 2. Have transportation and are willing to travel to the Hershey Community Garden 3. Have any two health conditions or risk factors for CVD. These but are not limited to: 1. Any history of cardiovascular disease 2. Any family history of premature cardiovascular disease 3. Any history of stroke 4. High cholesterol 5. High blood pressure 6. Overweight/obesity (BMI >=25) 7. Diabetes 8. Current or past Tobacco use  Currently tends a vegetable garden 2. Moving out of the area in the next 4 months 3. Non-English speaking 4. Pregnant women 5. Participation in a past gardening study 6. Medical conditions or medications that limit ability to freely increase dietary intake of fruits and vegetables (e.g., kidney failure, dialysis) 7. A medical condition that precludes safe pursuit of gardening, i.e., recent heart conditions (e.g., heart failure, stroke, heart attack), recent or pending surgery, severe orthopedic conditions, pending hip/knee replacement, paralysis, dementia, blindness, unstable angina or uncontrolled arrhythmias, or uncontrolled asthma or allergies. 8. History of difficulty obtaining blood samples or fear of needles
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson's Disease and Parkinsonism Informed consent is obtained from the participant The participant is clinically diagnosed with Parkinson's disease or the individual is a family member of a participant with LRRK2 parkinsonism or is a member of a high risk population with an early PD onset The participant is equal to or older than 18 years old  Inability to provide informed consent The participant is not suffering from Parkinson's disease or the individual is not a family member of a participant with LRRK2 parkinsonism or is not a member of a high risk population The participant is younger than 18 years old Previously enrolled in the study Participant in custody
Patient description: The patient is a 55-year-old man who was recently diagnosed with Parkinson's disease. He is complaining of slowness of movement and tremors. His disease is ranked as mild, Hoehn-Yahr Stage I. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with gardening before his diagnosis. He complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is offered Levodopa and Trihexyphenidyl. He is an alert and cooperative man who does not have any signs of dementia. He does not smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 40.0-75.0,  Parkinson Disease Confirmed Parkinson's Disease according to movement disorder neurologist with documented of other disorders such as fronto-temporal dementia (FTD)/ frontal gait disorder/normal pressure hydrocephalus (NPH)/progressive supranuclear palsy (PSP) 2. PD stage3 ON medication, with severe gait dysfunction and predominant axial symptoms: Movement Disorder Society-Unified Parkinson's Disease Rating Scale Tremor Dominant (MDS-UPDRS TD), Postural Instability Gait Difficulty (PIGD) ratio ≤ 0.90 and Freezing Of Gait Questionnaire (FOGQ) score > 12. 3. Age 40-75 with good response to Levodopa (defined as greater than 20% improvement in UPDRS score) 4. FOG refractory to mg 5. Insignificant tremor, bradykinesia, and rigidity symptoms, and poor candidate for Sub Thalamic Nucleus (STN) or Globus Pallidus Interna (GPi) DBS 1. Individuals with major executive dysfunction 2. Individuals with dementia, as defined by the Mattis Dementia Rating Scale-2 (DRS-2) score ≤ 130 3. Individuals with other neurocognitive impairments 4. Individuals who have depression, as defined for example by the Beck Depression Inventory II (BDI-II) > 25 5. Presence of major medical co-morbidities and other surgical contra-indications such as coagulopathy 6. Individuals who require diathermy, transcranial magnetic stimulation (TMS), or electroconvulsive therapy (ECT) 7. Individuals with a history of prior intracranial surgery 8. Individuals with a metallic implant in their head that is not MRI compatible (e.g., aneurysm clip, cochlear implant) 9. Individuals with active implantable devices anywhere in the body (e.g. cardiac pacemaker, defibrillator, spinal cord stimulator, implanted medication pump) 10. Individuals who are pregnancy or desire to become pregnant during the study 11. Individuals who are breastfeeding12