semaj83/ctmatch_classification huggingface dataset:
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Parkinson Disease Clinical diagnosis of Parkinson's disease, and either family history of Parkinson's disease (first or second degree family member affected by Parkinson's disease) AND/OR Clinical diagnosis of Parkinson's disease and their parents are close relatives(First or second degree family member of an Index Case, affected or unaffected by Parkinson's disease)  Lack of capacity to consent to participate in the project
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Diagnosis of idiopathic, typical Parkinson disease according to the UK Brain Bank Criteria; 2. Hoehn & Yahr stages 1-3 (mild to moderate disease severity); 3. Stable on all PD medications for at least 2 weeks prior to study entry; 4. Willing and able to provide informed consent  < 18 years of age; 2. Pregnant; 3. diagnosis of atypical Parkinsonism; 4. Hoehn & Yahr stages 4-5 5. a score of > 2 on item 7 of the new freezing of gait questionnaire (moderately or significantly disturbing freezing episodes during daily walking); 6. significant cognitive impairment; 7. unstable medical or concomitant illnesses or psychiatric conditions, which in the opinion of the investigators would preclude successful participation; 8. cardiac problems that interfere with ability to safely exercise 9. orthopedic problems in the lower extremities or spine that may limit walking distance; 10. unable to walk for 10 continuous minutes independently; 11. live in an institution or medical facility (i.e. not in the community)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Parkinson Disease Patients diagnosed with PD by the United Kingdom Parkinson's Disease Society Brain Bank clinical diagnostic or other standard criteria; PD patients detected with GBA gene variants
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Primary Osteoarthritis of Knee Nos Age 18 or older 2. Diagnosed with primary osteoarthritis and cleared to undergo total knee arthroplasty at the Virtua JRI 3. Willing to provide informed consent, participate in study, and comply with study protocol  Pregnant or contemplating pregnancy prior to surgery; 2. Worker's compensation or personal injury related to knee (clinical outcomes have been shown to be less predictable and often poorer in this patient group; there may also exist potential issues with reimbursement) 3. Post-traumatic arthropathy (clinical outcomes have been shown to be less predictable; pre-operative deformity and risk factors are greater and difficult to propensity-match between groups) 4. Self-pay patients or patients whose insurance are known to typically decline reimbursement for preoperative CT scans
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease for Parkinson's patients and "related diseases" controls Parkinsonian patients meeting the Gelb Patients with other neurodegenerative disease (such as other Parkinson syndrome or synucleopathies) meeting the set out in Appendix 2 (Lewy Bodies dementia, Parkinson's disease with dementia, MultiSystem atrophy, Progressive Supranuclear Paralysis) , Amyotrophic Lateral Sclerosis, Restless Legs Syndrome, Alzheimer's Disease) Woman of childbearing age having an effective means of contraception Informed consent signed by the subject or his legal representative For demented subjects coming for consultation or day hospitalization with an accompanying person, signature of the legal representative. for of non-ill controls Absence of rest trembling, bradykinesia and stiffness MMSE (Mini Mental State Examination) greater than 25 Woman of childbearing age having an effective means of contraception subject having signed the informed consent  for non-inclusion of patients Clinical for of the diseases described Participation in another therapeutic trial or in the period of a previous clinical trial. for non-inclusion of non-ill controls Functional discomfort in daily life of unknown cause MMSE less than 25 Participation in another therapeutic trial or in the period of a previous clinical trial
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Patient Involvement Medication Errors Self Administration Medication Adherence Patient Satisfaction Health Economics Patients admitted to the department "Medicinsk sengeafsnit 1", at Randers Regional Hospital Monday to Friday from 8.00 am to 6.00 pm Patients who are self-administering own drugs at home  Patients under 18 years old Patients who are not able to self-administer own drugs during hospital stay Patients who do not speak Danish Patients who can not or will not give informed consent
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 34.0-74.0,  Prostate Cancer Localized prostate cancer undergoing radical prostatectomy Patient has to understand and be able to write and read Finnish language No prior head injury, dementia or Parkinson's disease No concomitant malignant illness Life expectancy of at least 10 years 74 years of age  Locally advanced prostate cancer (T4) Suspicion or documented metastases (M1) Serum PSA > 20 ng/ml Prior laparoscopic hernia surgery employing non resorbable mesh Prior pelvic irradiation or major surgery Prior malignant disease within prior 5 years excluding skin cancer (non-melanoma)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-80.0,  Parkinson's Disease Mpulse Control Disorders Patients with PD according to MDS (movement disorders society) for at least one year Patients with ICD with a QUIP-RS score ≥10 and/or at least one of the sub-scores in the following range: Pathological gambling between >6 and 12; Pathological gambling between >8 and 12; Hypersexuality between > 8 and 12; Eating between > 7 and 12. The use of "lower" margins will guarantee that patients will present behavioral disturbances severe enough to justify clonidine treatment. On the other hand, the use of "upper" margins will guarantee that the patients included in the trial will not suffer from ICD too severe to ethically participate to a placebo controlled study Weight between 40 and 95kg Stable antiparkinsonian medication since at least 2 months before randomization and medication supposed to remain stable during the study ICD onset after Parkinson's disease onset and after initiation of dopaminergic drugs No signs of dementia (Montreal Cognitive Assessment, MOCA >20) No lactose intolerance which may compromise the tolerance of the placebo Patients with health insurance Patients without judicial protection measure except directly linked to ICD For women of childbearing potential, an effective contraception method for at least 2 months before randomization (as implants or oral oestro-progestative contraceptives), condom use for men during the study. βHCG dosage in urine should be negative at randomization for women  Patients with major depression (BDI >19) Patients with another parkinsonian syndrome (Parkinson "plus" or vascular Parkinsonism) Orthostatic hypotension Patients with swallowing disorders that may prevent oral medication Contraindication to clonidine: Hypersensibility; Severe bradyarythmia due to a cardiac disease Patients receiving a treatment potentially interacting with clonidine Patients with Raynaud's disease or obliterating thromboangiitis Patients With Heart failure or severe coronary artery disease Patients with a drug treatment having a potential interaction with clonidine (see list, appendix 2) Presence of renal failure (Cockcroft-Gault at visit<30 ml/min/1,73m2)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 25.0-90.0,  Parkinson Disease, Essential Tremors and Dystonia Dopa responsiveness 2. Minimum disease duration of 5 years. 3. Diagnosis of idiopathic Parkinsons disease 4. Patients with intractable Essential Tremors. 5. Patients with intractable dystonia  Significant medical health problems. 2. Significant cognitive impairment 3. Bleeding tendencies
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 30.0-999.0,  Parkinson Disease Parkinson's disease Stable on levodopa therapy with fluctuations  Chronic gastrointestinal disease Recent antibiotic or probiotic therapy Pregnant Immunocompromised
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Chest Pain Coronary Artery Disease Acute Coronary Syndrome Ischemic Heart Disease Patients above 18 years of age with ischaemic sounding chest pain prompting visit to the emergency department (suspected ACS). 2. No-ischaemic ECG changes (i.e. no ST-segment elevation or depression 1mm in 2 or more contiguous leads, and/or T-wave inversions). 3. Episode of chest pain within last 12 hours. 4. Initial troponin in the intermediate range (5-50ng/L)  STEMI. 2. Signs and symptoms of acute heart failure and/or haemodynamic instability. 3. Dynamic ischaemic ECG changes. 4. Patient not suitable to undergo CTCA 1. Inability to breath hold for 10 seconds 2. Severe renal impairment (eGFR <30 mL/min) 3. Contraindication to beta-blockers (not relevant for patients with baseline sinus rhythm at rate of <63bpm) 5. Atrial Fibrillation on ECG. 6. Patients with known significant obstructive coronary artery disease (>50% stenosis) on previous invasive or CT coronary angiogram. 7. Patients with previous PCI/CABG revascularisation. 8. Patients with a history of congenital heart disease. 9. Patients with known coronary artery anomalies. 10. Patients who lack capacity to give consent or participate in the study. 11. Previous recruitment to the present study. 12. Known pregnancy or patients who are currently breast feeding. 13. Prisoners. 14. Patients involved in current or a recent (within the last 4 months) CTIMP trial
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-85.0,  Parkinson Disease Dementia Mild Cognitive Impairment Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Cognitive function score >=16 on Montreal Cognitive Assessment (MoCA) Diagnosed with Parkinson's disease, Hoehn and Yahr stage 1 to 4 Able to walk 10 meters without stopping and without human assistance (using assistive devices such as cane or walker if normally used) Waist and leg circumference and lower extremity lengths appropriate for a comfortable and safe fit in the device  Legally blind Treatment with another investigational drug or other intervention within the study period New medications started within last 4 weeks Skin condition that contraindicates use of orthotics or support braces Lower-extremity amputation above or below the knee Uncontrolled orthostatic hypotension Psychiatric disorders such as schizophrenia or bipolar disorder Other diagnosis that impairs gait and balance, such as, but not limited to, chronic obstructive pulmonary disease; peripheral arterial disease; vestibular disorders; cerebellar disease; cerebral palsy; muscular dystrophy; spinal cord injury; stroke or other brain injury; severe degenerative joint disease (osteoarthritis, rheumatoid arthritis, etc.)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Cirrhosis Hepatic Encephalopathy Minimal Hepatic Encephalopathy Covert Hepatic Encephalopathy Age >18 years 2. Cirrhosis defined by any one of the following 1. Cirrhosis on liver biopsy or transient wave elastography 2. Nodular liver on imaging 3. Endoscopic or radiological evidence of varices in a patient with chronic liver disease 4. Platelet count <150,000/mm3 and AST/ALT ratio >1 in a patient with chronic liver disease 5. Patients with frank decompensation (ascites, HE, variceal bleeding, hepato-pulmonary syndrome) 3. Prior HE controlled on standard of care therapy defined as lactulose or rifaximin for at least 2 months prior to enrollment. 4. Serum albumin <4 gm/dl 5. Cognitive impairment on any of the three testing strategies for HE including Psychometric hepatic encephalopathy score (PHES), Stroop test and Critical Flicker Frequency 1. PHES aggregate score <-4SD based on norms published in Allampati et al located at the website www.encephalapp.com 2. Stroop OffTime+OnTime values greater than norms published in Allampati et al located at the website www.encephalapp.com 3. Critical Flicker Frequency value <39 Hz  Unclear diagnosis of cirrhosis (does not meet the outlined above) 2. No prior overt HEepisodes 3. HE uncontrolled on standard of care defined as a mini-mental status exam<25 4. On regular IV albumin infusions due to scheduled paracentesis within the last 3 months 5. Recent alcohol abuse (within 3 months) 6. Unable to give consent 7. Current or recent invasive bacterial or fungal infections (<1 month) 8. Allergic reactions to IV albumin 9. Current or recent congestive heart failure (Systolic ejection fraction <25%) within the last year 10. Pregnancy (positive urine pregnancy test at screening) 11. In the opinion of the PI, those who are unlikely to survive 6 weeks or be able to adhere to the trial activities