Patient description: The patients is a 25-year-old G1 P1 pregnant woman who is 24W3D gestational old who developed a sudden unset of fever and chills, accompany with nausea and vomiting. She also complains of dysuria, urgency and frequency. She also reports some severe pain in the flank. Her vital signs are: T = 39.7ºC, P = 117, R = 20, and BP = 113/74 mm Hg. Physical examination reveals tenderness on palpation of both costovertebral angles. She has no history of recurrent UTI prior to her pregnancy or any other underlying disease. The urine culture showed Gram-negative rod-shaped bacterial cells, leukocytes, and leukocyte casts. The blood culture is negative. A CBC shows Hb 12.9 g/dL, Hct 39%, MCV 76 fL, WBC count 14,120/µL.

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Healthy Volunteers Men and non-pregnant/lactating women between the ages of 18 and 45. 2. Self reported African American or Caucasian racial-ethnic background. 3. Body Mass Index (BMI) of ≥ 18 and ≤ 30. 4. Participants who are able to give written informed consent and willing to comply with all study-related procedures  Known clinically manifest atherosclerotic cardiovascular disease, including coronary disease, cerebrovascular disease, or peripheral vascular disease. 2. History of diabetes mellitus. 3. Fasting glucose > 126 mg/dL. 4. History of a non-skin malignancy within the previous 5 years. 5. Renal insufficiency as defined by creatinine > 1.5 mg/dl at Screening Visit. 6. History of liver disease or abnormal liver function tests (LFTs) (AST, ALT, Alk. Phos., GGT > 1.5x upper limit of normal (ULN); bilirubin > 2x ULN) at Screening Visit. 7. Men who are unwilling to limit alcohol consumption to <14 alcoholic drinks per week or < 4 alcoholic drinks per occasion (AMA / NIAAA for "at risk" usage levels) while participating in the study. 8. Women who are unwilling to limit alcohol consumption to < 7 alcoholic drinks per week or < 3 alcoholic drinks per occasion (AMA / NIAAA for "at risk" usage levels) while participating in the study. 9. Total white blood cell count less than or equal to 3.0 THO/uL. 10. Hemoglobin below 11.0 g/dL. 11. Any major active rheumatologic, pulmonary, or dermatologic disease or inflammatory condition or minor active infection. 12. History of HIV positive. 13. First degree family history of premature cardiovascular disease event (father or brother if diagnosed at before 55 years of age; mother or sister if diagnosed before 65 years of age). 14. Patients who have undergone any organ transplant. 15. Individuals who currently use tobacco products or have done so in the previous 30 days. 16. Treatment with aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, steroids or any immunomodulatory therapy 2 weeks prior to the Screening Visit. 17. Treatment with statins, fibrates or niacin 4 weeks prior to the Screening Visit. 18. Current daily use of Vitamin C > 1000 mg, Beta carotene > 1000 IU, vitamin A > 5000 IU, vitamin E > 400 IU, and selenium > 200 mcg. 19. Positive urine pregnancy at the Screening Visit. 20. Participation in another clinical trial within the previous 6 weeks prior to the Screening Visit. 21. Poorly controlled blood pressure (BP > 160/110) or on any anti-hypertensive medications. 22. A diagnosis of metabolic syndrome using updated 2004 NCEP criteria. 23. A history of severe lactose intolerance (e.g., intolerance of any milk intake). 24. Any medical condition or abnormal laboratory value that is judged clinically significant by an investigator