semaj83/ctmatch_classification huggingface dataset:
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Advanced Cancer FOR Able to speak and understand English Over age 18 NEW diagnosis, recurrence, or progression of an advanced stage cancer within days of the date the patient was informed of the diagnosis by his/her oncology clinician Estimated survival of 2 years or less Diagnosed with an advanced stage cancer such as one of the following Lung Cancer: Stage IIIB or IV non-small cell, or extensive stage small cell Breast Cancer: Stage IV with poor prognostic indicators including but not limited to: a) >2 cytotoxic regimens for MBC; b) diagnosis of MBC less then or equal to 12 months since completion of adjuvant or neoadjuvant treatment; c) triple negative disease (ER/PR and Her 2-);d) parenchymal brain mets and/or carcinomatous meningitis Gastrointestinal (GI) Cancers: Unresectable stage III or IV  Dementia or significant confusion (Impaired cognitive status as indicated by a score of 3 or less on the Callahan six-item cognitive screening tool 18) Axis I psychiatric diagnosis of severe mental illness (DSM-IV) (e.g. schizophrenia, bipolar disorder, or active substance use disorder) Patients will not be excluded if they do not identify a caregiver Prior involvement with palliative care service within the last year Minimum predicted survival of less than 12 weeks (3 months) Receiving chronic steroid hormones or unable to schedule specimen collection distant from chemotherapy from steroid pre-medications Unable to come to Norris Cotton Cancer Center (NCCC) for specimen collection times Unwilling to participate in study
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Gait Apraxia Alzheimer Disease Impaired Cognition Diagnosis of Alzheimer's disease (AD) (DSM-IV/NINCDS-ADRDA criteria) Age ≥ 65 years old Mild AD (Mini-Mental State Examination score between 21 and 25), moderate AD (Mini-Mental State Examination score between 10 and 20) and severe AD (Mini-Mental State Examination score between 3 and 9) Able to walk without any aid on 15 meters Near visual acuity ≥ 2 Absence of severe depression (score of the 15-item Geriatric Depression Scale ≤ 10) Written consent form to participate in the study (or trustworthy person or legal representative for severe AD) Being affiliated to a social security regime  Musculoskeletal disorders not related to Alzheimer's disease Near visual acuity < 2 History of cerebrovascular accident or other cerebro-spinal pathology Poor workmanship of the written or oral French language Refusal to be informed on possible hanging bare anomaly during study Score of Mini-Mental State Examination < 3 Presence of severe depression (score of the 15-item Geriatric Depression scale > 10) Use of walking aid Subject suffering from pre-existing impellent disturbances Refusal to participate (or trustworthy person or legal representative)
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 60.0-999.0,  Alzheimer's Disease Clinical diagnosis of Alzheimer's Disease MMSE score of 14-26  Visual impairment Auditory impairment Psychiatric disorders
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 70.0-75.0,  Dementia Alzheimer Disease Vascular Dementia to be resident in Abbiategrasso to be born between 1935 and 1939  to refuse to participate te be not contactable in any way (mail, telephone) to be legally resident, but actually living somewhere else
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Dementia for Veterans with dementia English speaking diagnosed with dementia as above able to participate in at least two activities of daily living ADLs bathing dressing grooming toileting transferring from bed to chair  Non English speaking Non-Veteran No caregiver No diagnosis of dementia
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Mild Cognitive Impairment Clinical diagnosis of Mild Cognitive Impairment  Clinical diagnosis of dementia History of neurological conditions known to impair cognition History of alcohol or drug abuse History of chronic psychiatric illness Current symptoms of moderate to severe depression (Geriatric Depression Scale >19) or anxiety (Beck Anxiety Inventory >15)
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Dementia Surrogate for nursing home resident with advanced dementia, paired with resident with advanced dementia  Non-related legal surrogate without personal knowledge of resident
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Alzheimer's Disease Dementia Family Caregivers to be a family caregiver of an person diagnosed with possible or probable Alzheimer's disease or other advanced stage dementia show interest in participating Sign informed consent Alzheimer's or dementia person to have a probable or possible Alzheimer type dementia or other advanced dementia according to a diagnosis done by a Specialized Evaluation Unit GDS 5-6 and a minimental equal or lower than 12 to preserve a verbal comprehension of basic instructions to preserve the mobility of the arms, as well as the visual and auditive capacities that allow to conduct the activities  Caregivers to have a negative attitude towards the emotional interaction with his/her Alzheimer or dementia family member Unavailability to participate in other socio-educative interventions during the study period Any other situation that makes the caregiver as not suitable according to investigator's Alzheimer's or dementia person Do not have the sensorial or motor capacities needed for the interaction Serious impairment of the verbal comprehension Disabling health conditions
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 50.0-999.0,  Alzheimer's Disease, Mild to Moderately Severe Stages of AD Community Dwelling Patients With Family Caregiver Quality of Life patient suffering from mild to moderately severe Alzheimer's disease patients (MMSE 11 to 26) in community dwelling with an informal caregiver (person living with the patient or providing care 3 times a week or 8 hours per week) is informed and has given his/her consent whom caregiver is informed and has given his/her consent  patient with other type of dementia living in nursing home or long term care with no caregiver not informed or has not given his/her consent whom caregiver is not informed or has not given his/her consent
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 0.0-69.0,  Frontotemporal Dementia Alzheimer's Disease. Debut of dementia symptoms before the age of 65 years, but age at time of may be up to 70 years FTD (Neary et al 1998 criteria) Primary progressive aphasia (Mesulam 2003 criteria) AD (DSM-IV) Community living, excl. dementia-specific living facilities manned 24/7 Family member with regular contact at least x 1/week  Lack of informed consent No close or appropriate family member Frontal lobe dysfunction due to non-progressive injury, i.e. cerebral infarction Frontal lobe dysfunction due to motor neuron disease (ALS) Other dementia specific condition with frontal lobe dysfunction (Huntington, HIV, Down syndrome, alcoholic dementia) Mental retardation Current substance abuse, incl. excessive alcohol consumption for the past 12 months
Patient description: An 89-year-old man was brought to the emergency department by his wife and son after six months of progressive changes in cognition and personality. He began to have poor memory, difficulty expressing himself, and exhibited unusual behaviors, such as pouring milk onto the table and undressing immediately after getting dressed. He is unable to dress, bathe, use the toilet, or walk independently. On examination the patient's temperature was 36.5C (97.7F), the heart rate 61 bpm in an irregular rhythm, the blood pressure 144/78 mm Hg, and the respiratory rate 18 bpm. The patient was alert and oriented to self and city but not year. He frequently interrupted the examiner. He repeatedly reached out to grab things in front of him, including the examiner's tie and face. He could not spell the word "world" backward, could not follow commands involving multiple steps and was unable to perform simple calculations. His speech was fluent, but he often used similar-sounding word substitutions. He could immediately recall three out of three words but recalled none of them after 5 minutes. Examination of the cranial nerves revealed clinically significant paratonic rigidity. Myoclonic jerks were seen in the arms, with symmetrically brisk reflexes. The reflexes in

Clinical trial eligibility criteria: eligible ages (years): 55.0-999.0,  Family Member Men and women ages 55 years and over English or Spanish speaking Interest in participating in a novel nutritional supplement program Willingness to follow recommendations, including going off of all vitamin-D and calcium containing supplements, multivitamins, or OTC medications (e.g., Tums) 2 weeks before starting the study and during the intervention Scoring 0-2 errors on the Short Portable Mental Status Questionnaire  Less than 55 years of age Currently enrolled in another research trial for vitamin D dietary supplements or other bone disease treatments Unable to consent to the study Living in a skilled or intermediate care level nursing facility Women who are pregnant, during their period, or less than 2 days before or after their period at the time of the assessment Psychiatric diagnosis of schizophrenia, other psychotic disorders, bipolar disorder, major depression with psychotic features, delirium, and alcohol or substance abuse/dependence Bleeding disorders Aphasia or sensory, motor, and/or visual disturbances that could interfere with assessments, including inability to walk 10 feet without a walking aid Gastrointestinal disorders that could lead to uncertain resorption of the study supplements Major conditions such as neurologic, cardiovascular, pulmonary, renal, endocrine, thyroid, hepatic, autoimmune, or bone/joint that could interfere with vitamin D metabolism, psychometric tests, or body composition assessment (especially renal and heart failure)