Patient description: The patient is a 45-year-old postmenopausal woman with cytologically confirmed breast cancer. A core biopsy revealed a 3 cm invasive ductal breast carcinoma in the left upper outer quadrant. The tumor is HER2-positive and ER/PR negative. Axillary sampling revealed 5 positive lymph nodes. CXR was remarkable for metastatic lesions. The patient is using multivitamins and iron supplements. She does not smoke or consume alcohol. She is not sexually active and has no children. She is a candidate for tumor resection and agrees to do so prior to chemotherapy.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  HER2-positive Breast Cancer Stage I Breast Cancer Female participants who are at least 40 years of age on the day of signing the informed consent form with histologically confirmed diagnosis of breast cancer. 2. A participant is eligible to participate if she is not pregnant, not breastfeeding. 3. The participant (or legally acceptable representative if applicable) provides written informed consent for the trial. 4. Histologically confirmed invasive adenocarcinoma of the breast, with all of the following characteristics HER2-positive status by local determination according to 2018 ASCO/CAP guidelines PAM50 HER2-enriched subtype and ERBB2-high as predefined cutoff as per central determination Unifocal invasive carcinoma: only 1 invasive focus can be observed (the tumor focus containing or not containing an in situ component) Tumor largest diameter ≤2 cm as defined by breast MRI No nodal involvement (i.e. cN0). Any suspicious axillary node by ultrasound must be biopsied. If the biopsy or the FNA is negative of tumor cells, patient is eligible No evidence of distant metastasis (M0) by routine clinical assessment. 5. Patient must have known ER and PR status locally determined prior to study entry. 6. Eligible for taxane therapy. 7. Willingness of the patient to omit surgery if all are met following neoadjuvant therapy. 8. Estimated life expectancy of at least 5 years irrespective of the diagnosis of breast cancer. 9. Breast cancer eligible for primary surgery 10. Have provided archival tumor tissue sample or newly obtained core. Formalin-fixed,paraffin embedded (FFPE) tissue blocks are mandatory. Available pre-treatment FFPE core biopsy evaluable for PAM50 or possibility to obtain one. 11. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. 12. Ability and willingness to comply with study visits, treatment, testing and to comply with the protocol. 13. Have adequate organ function  Has received prior anti-cancer therapy, including investigational agents, or treatment for primary invasive breast cancer. 2. Known hypersensitivity to any of the excipients of trastuzumab, pertuzumab, TDM1 or paclitaxel. 3. Clinical stage II, III or IV. 4. History of radiotherapy in the ipsilateral breast or axilla. 5. History of surgery of the ipsilateral axilla. 6. Bilateral invasive breast cancer. 7. Infiltrating lobular carcinoma. 8. Multicentric or multifocal breast cancer, defined as the presence of two or more foci of cancer in the same or different quadrants of the same breast. 9. Patients who have undergone sentinel lymph node biopsy prior to study treatment. 10. Patient has active cardiac disease or a history of cardiac dysfunction 11. Has an active infection requiring systemic therapy. 13. Patients with a history of previous breast cancer are excluded