semaj83/ctmatch_classification huggingface dataset:
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Post Menopausal Osteoporosis women who have been newly diagnosed with post-menopausal osteoporosis, requiring treatment naive to bisphosphonate treatment,or had bisphosphonate treatment for a maximum of 3 months, at least 5 years before screening  patients on HRT within the last 3 months patients on other osteoporosis medication within the last 3 months sCTX below lower limit, or above 3 times the upper limit, of normal premenopausal level hypersensitivity to any component of ibandronate contraindication for calcium or vitamin D therapy history of major gastrointestinal upset malignant disease diagnosed within the previous 10 years (except resected basal cell cancer)
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Vitamin D Deficiency Healthy African-American and Caucasian adults aged 18-65 years  Subjects who are not either African-American or Caucasian. The investigators plan to examine racial differences in response to oral vitamin D dosing and, therefore, have chosen the most affected (African-American) and the least affected (Caucasian) racial groups. Including other racial/ethnic groups may confound the results unless they are studied as separate groups Any chronic medical illness including diabetes mellitus, history of myocardial infarction or heart failure, malignancy, hypertension (systolic blood pressure [SBP] > 140), obesity (body mass index [BMI] > 35 kg/m2), history of anemia, leukemia, or other hematologic abnormalities, lupus, rheumatoid arthritis, or other rheumatologic disease, or kidney disease of any kind as determined by history and physical examination Subjects with osteoporosis or taking medications for osteoporosis such as bisphosphonates Pregnancy Use of medication that influences bone metabolism (i.e. anticonvulsant medications, steroids, diuretics) Significant deviation from normal in either history, physical examination, or laboratory tests, as evaluated by the primary investigator Patients with a history of hypercalciuria, hypercalcemia, nephrolithiasis, and active sarcoidosis Participation in another investigational trial in the past 30 days prior to the screening evaluation Unexplained weight loss of > 15% during the previous year or history of anorexia nervosa Medications that interfere with vitamin D metabolism. Oral contraceptive use will be allowed, but will be appropriately documented
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 40.0-999.0,  Osteoporosis Postmenopausal women and men over the age of 40 who are starting therapy with teriparatide  Patients with diabetes mellitus current smokers patients with a history of organ transplantation Patients currently of previously on glucocorticoid therapy within the past year Patients with serum creatinine above 1.5 mg/dl, patients with uncontrolled hypertension (BP 140/90 or greater) Patients ineligible for teriparatide therapy: History of metabolic bone disease other than osteoporosis History of radiation therapy Patients pregnant or nursing History of bone metastasis or skeletal malignancies History of hypercalcemia
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 0.0-59.0,  Osteoporosis Postmenopausal, asthmatic outpatients under 60 years of age on long-term oral or inhaled glucocorticoid treatment for at least one year  Hysterectomy, history of breast or endometrial cancer, undiagnosed pelvic or breast mass, untreated hypertension
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 45.0-80.0,  Healthy 55 or 70-80 years old History of natural menopause defined by the absence of menses for at least 12 months (or history of surgical menopause defined as bilateral oophorectomy) and a FSH level >26 IU/L On no hormonal medication or herbal supplements and/or over the counter menopause therapy for a minimum of 2 months prior to study Normal TSH, PRL, factor V, and CBC Normal BUN and Creatinine (< 2 times the upper limit of normal) BMI ≤ 30 Non-smokers or smoke less than 10 cigarettes/day  Absolute contraindications to the use of physiologic replacement doses of estrogen, including a negative screening mammogram within the past 24 months History of coronary artery disease On medications thought to act centrally on the GnRH pulse generator Past history of hypersensitivity or allergy to narcotics, vancomycin, muscle relaxants, aspirin, and/or anaphylactic reaction(s) to other drugs Prior history of breast cancer and/or blood clots
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Osteoporosis osteoporosis (DXA T-score < -2.5 in hip and/or vertebrae) able to walk at least 15 minutes without an helping device years or older community dwelling at least one fall in the prior year  severe cardiac, pulmonary or musculoskeletal disorders pathologies associated with increased fall risks (i.e. stroke or Parkinson's disease) use of psychotropic drugs
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Schizophrenia Alcohol Abuse DSM-IV diagnosis of schizophrenia Onset of illness more than 5 years  No severe Medical and endocrinological disorder
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Post-Menopausal Osteoporosis post-menopausal women >=3 months daily or weekly alendronate or risedronate for treatment or prevention of post-menopausal osteoporosis  inability to stand or sit in an upright position for at least 60 minutes hypersensitivity to bisphosphonates treatment with other drugs affecting bone metabolism abnormalities of the oesophagus, which delay oesophageal emptying
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 50.0-999.0,  Osteoporosis Presented to Modbury Hospital's Accident and Emergency Department with a new bone fracture  Residence in nursing home Fracture sustained in motor bike, push bike or motor vehicle accident Fracture sustained due to high trauma, such as fall from roof or ladder Dementia Inability to participate in group settings Inability to understand spoken English Inability to provide informed consent Pathological fracture Usual place of residence outside South Australia
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 50.0-90.0,  Osteoporosis Bone Loss, Age Related Postmenopausal Bone Loss Postmenopausal Osteoporosis Female, post-menopausal women aged 50 to 90 Have a bone mineral density (BMD) evaluation resulting in a T-Score of <-1.0 Have a follow-up appointment with a provider in the areas of Family Medicine (FM), Primary Care Internal Medicine (PCIM), or POM Have no major barriers (i.e., severe hearing impairment, dementia, require interpreter, etc.) to participation in shared decision-making (per provider's assessment) Enrollment is open to females of diverse racial backgrounds  Currently taking a bisphosphonate Not available for 6 month follow-up phone call
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Osteoporosis Rheumatoid Arthritis Meet American College of Rheumatology for rheumatoid arthritis Taking an oral glucocorticoid equivalent to 5 mg/day of prednisone for at least one month prior to study entry Age 18 or older  Existing osteoporosis Pregnancy Breast feeding History of breast cancer Physician recommendation to limit calcium intake Class IV rheumatoid arthritis
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 45.0-55.0,  Osteoporosis Female Age 45 (inclusive) to 55 years (inclusive) Race: Caucasian Non-smokers / Smokers up to 10 cigarettes/day Postmenopausal hormone status: 1-3 years since the last spontaneous menstrual bleeding and a follicle-stimulating hormone concentration (FSH) >75 IU/ml and 17-estradiol (E2) of < 20 ng/L Years since menopause between 1-3 years Natural menopause or total hysterectomy with bilateral salpingo-oophorectomy Subjects with E2 results within the range will be assessed on an individual basis if FSH level is less than 75 IU/ml Assessed as age-related healthy, based on a pre-study examination including medical history, physical examination, ECG, vital signs and clinical laboratory. The examination will be performed by a MD at the study site within 1-2 months prior planned study start for the individual subject Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements  T-score < -2.5 at total hip and spine (either or both) Suspect lack of compliance BMI > 30 or < 21 Use of HRT within the previous 6 months Use of any drug which might interfere with bone-metabolism (bisphosphate, estrogen receptor modulators, calcitonin) within the previous 12 months Systematic practice of high intensity exercise Vegetarian nutrition or any other extreme dietary habits Use of dietary supplements while on study, except multi vitamin. No "wash out" period for supplements must stop before run-in period and refrain until the end of the study Participant in any other study or donation of blood during the last 30 days before start of each dosing phase (T0)
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 55.0-75.0,  Osteoporosis Postmenopausal female, 55-75 years old History of Type II diabetes, as defined by the American Diabetes Association for more than 5 years that is either insulin requiring or treated with oral therapies such as sulfonylureas and metformin Body mass index (BMI) of 19-35 Able to move without walkers and without a history of long periods (>3 months) of inactivity Additional for fracture participants Fractures of the proximal humerus and femur as well as the ankle and foot should have occurred after the onset of diabetes and should have been caused by a low energy trauma such as falling from standing height. All fractures will be verified by radiographs  Severe neuropathic disease such as neurogenic osteoarthropathies (i.e., Charcot joints) of the foot Steroid users or have disease conditions that could play a significant role in the development of osteoporosis such as idiopathic osteoporosis, immobilization, hyperparathyroidism, or hyperthyroidism Diseases that may affect bone metabolism: alcoholism, chronic drug use, chronic gastrointestinal disease, renal or hepatic impairment Chronic treatment with antacids, estrogen, adrenal or anabolic steroids, anticonvulsants, anticoagulants, or pharmacologic doses of Vitamin A supplements 6 months prior Diabetic patients on rosiglitazone or pioglitazone medications high energy trauma, e.g., due to motor vehicle accidents Pathological fractures of other origin, i.e., tumor, tumor-like lesions as well as focal demineralization visualized on radiographs History of fluoride, bisphosphonate, calcitonin or tamoxifen use History of unstable cardiovascular disease or uncontrolled hypertension MRI contraindications
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 45.0-85.0,  Osteoporosis Healthy women aged 45 and above who have been menopausal at least 1 year (absence of menstrual period for a period of 12 months or more)  Any chronic medical illness including uncontrolled diabetes mellitus, recent history of myocardial infarction, or heart failure, malignancy, uncontrolled hypertension, obesity (BMI>35 kg/m2), history of anemia, leukemia, or other hematologic abnormalities, lupus, rheumatoid arthritis, or other rheumatologic disease, or kidney disease of any kind as determined by history and physical examination Subjects with osteoporosis of the hip (total hip T-score equal or less than -2.5) or taking medications for osteoporosis such as bisphosphonates will be excluded Pregnancy Use of medication that influences bone metabolism (i.e. anticonvulsant medications, chronic use of steroids and high dose diuretics) Significant deviation from normal in medical history, physical examination, or laboratory tests as evaluated by the primary investigator Patients with a history of hypercalciuria, hypercalcemia, nephrolithiasis, and active sarcoidosis will also be excluded Participation in another investigational trial in the past 30 days prior to the screening evaluation Unexplained weight loss of >15% during the previous year or history of anorexia nervosa Medications that interfere with vitamin D metabolism Patients with a habitual dietary calcium intake that exceeds 800 mg/day
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 18.0-55.0,  Osteoporosis Women between the age of 18-55, pre-menopausal by history (regular spontaneous menstrual bleeding every 21-35 days) or documented FSH <10, no current estrogen therapy, undergoing hysterectomy with (ovx) or without ovariectomy (control group) for benign gynecologic disease (fibroid uterus, endometriosis, dysfunctional uterine bleeding, chronic pelvic pain) or for prophylaxis against ovarian cancer (BRCA positive)  History of an active cancer including breast and uterine cancer, treatment with chemotherapy or glucocorticoids History of an immune deficiency syndrome including HIV infection History of severe anemia with hematocrit < 25
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 21.0-70.0,  Risk Drinking,Diabetes, Hypertension, Osteoporosis, Infertility has diabetes, hypertension, osteoporosis, or infertility 2. Not currently receiving treatment for alcohol or drug problems or substance related medical illness 3. Not currently experiencing physical dependence on alcohol, requiring medically supervised detoxification 4. Not currently abusing or physically dependent on opiates, cocaine, or other illicit drugs 5. Not currently pregnant. Subjects with infertility may become pregnant during the course of the study Not currently nursing. 7. Able to complete study measures  Alcohol screen negative or drinks within NIAAA sensible drinking limits for women Does not agree to randomization and study terms
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 40.0-60.0,  Osteoporosis All patients meet the Patients with informed consent Breast Cancer inform possible danger Physical and mental health Menopausal transition meet the Age between 40 ~ 55 years old Women with Menopause syndrome or menstrual disorders The second to fourth lumbar spine bone mineral density to normal Early postmenopause meet the Age between 45 ~ 60 years old  Tobacco or alcohol abuser History of various malignant diseases Women with Serious chronic diseases, such as liver and kidney dysfunction Women Suffering from endocrine diseases, such as Thyroid disease, Parathyroid disease,Adrenal disease and Osteomalacia Women with Long-term application of drugs, such as Antiepileptic drug, Adrenocorticotropic hormone, Diuretics and Heparin Women had used estrogen or calcitonin in the past 6 months Women has added higher than the physiological requirements VitD Who had taken bisphosphonates or sodium fluoride in the past 1 year Women had been taking Chinese medicines or other unregistered food in past 3 months Women with one of the following medical history or disease: Thrombophlebitis, estrogen-related thrombosis or thromboembolism, Cerebrovascular accident, with known or suspected estrogen-dependent tumor, undiagnosed vaginal bleeding, Cervical Pap smear graded at 3 or more, Serious uterine disorders, Serious breast disorders, Serious gallbladder disease, Severe hypertension and Hypercholesterolemia
Patient description: A 51-year-old woman is seen in clinic for advice on osteoporosis. She has a past medical history of significant hypertension and diet-controlled diabetes mellitus. She currently smokes 1 pack of cigarettes per day. She was documented by previous LH and FSH levels to be in menopause within the last year. She is concerned about breaking her hip as she gets older and is seeking advice on osteoporosis prevention.

Clinical trial eligibility criteria: eligible ages (years): 65.0-999.0,  Type 2 Diabetes Mellitus female >= 65 years old postmenopausal for > 5 years (WHO definition of menopause)  currently taking osteoporosis related medication (HRT, SERM, bisphosphonate, PTH, calcitonin, fluoride) had cancer in past 10 years, likely to metastasize to bone (ie: breast, lung) have intrinsic bone disease (ie: Paget's Disease, Cushings syndrome) have untreated malabsorption syndrome (ie: Celiac Disease) renal insufficiency (CrCl <30ml/min) hyperparathyroidism, hypoparathyroidism chronic systemic glucocorticosteroid use > 3mos, dose>2.5mg daily