semaj83/ctmatch_classification huggingface dataset:
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 25.0-45.0,  Bipolar Disorder No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening  Participation in a clinicl trial within 30 days prior to study initiation Positive test for HIV, Hepatitis B, or Hepatitis C Treatment with known enzyme altering drugs
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-38.0,  Bipolar Disorder No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening  Positive test for HIV, Hepatitis B, or Hepatitis C Treatment with known enzyme altering drugs History of allergic or adverse response to lithium, or any comparable or similar product
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Bipolar Disorder Depression Meets DSM-IV for Axis I bipolar II disorder Meets DSM-IV for Axis I major depressive episode Score of 16 on 17-item HAM-D rating scale Not taking monoamine oxidase inhibitors (MAOI) for more than 2 weeks prior to study entry Willing to use an effective form of birth control throughout the study  History of mania Current primary Axis I diagnosis other than bipolar II disorder Alcohol or drug dependence within 3 months prior to study entry Contraindication to treatment with venlafaxine or lithium Unstable medical condition (e.g., thyroid disease, hypertension, or angina pectoris) Pregnant or breastfeeding Experiencing suicidal thoughts Requires hospitalization Requires concurrent neuroleptic or MS therapy Requires concurrent AD therapy
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-35.0,  Weight Gain Age 18-35 Body mass index between 23 and 30 Interested in preventing weight gain  BMI outside of range specified Age outside of range specified History of or current eating disorder or substance abuse Recent weight loss greater than 5% of weight Currently in another research study that would interfere
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 12.0-35.0,  Depression, Bipolar Depressed bipolar patients (N=100; 15-20 patients/year) Patients will meet DSM-IV for type I bipolar disorder, depressed, as determined by structured interview and best-estimate diagnostic procedures.138 Patient has experienced a maximum of three documented affective episodes Patient has been off medications for one week prior to study enrollment Patient has a Hamilton Depression Rating Scale (HDRS) total score ≥20 Patient is between the ages of 12 and 35 years  All subjects will be excluded from participation for the following reasons Any chemical use disorder within 3 months Any history of significant suicidality that would place the patient at risk to participate in this protocol Current score ≥3 on item 3 of the HDRS-17 (Suicide Item) Any medical or neurological disorder that could influence fMRI results A history of mental retardation or an estimated IQ total score <85 An MRI scan is contraindicated in the subject for any reason The patient lives >100 miles from the University of Cincinnati or cannot attend follow-up visits Meets DSM-IV for a bipolar mixed episode
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-64.0,  Sleep Initiation and Maintenance Disorders Diagnosis of primary insomnia based on Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Depression DSM-IV diagnosis of major depressive disorder (MDD) Drug naive from prior psychotropic medication for more than 6 months before study entry Hamilton-Depression (HAM-D) 17 score greater than or equal to 16 Woman of childbearing age with a negative pregnancy test within 48 hours of scanning  DSM-IV Axis I diagnosis other than MDD Use of psychotropic medication within 6 months of study entry History of bipolar disorder Current alcohol or drug abuse/dependence within 6 months of study entry History of sensitivity or intolerance to s-citalopram Medical contraindication to the use of s-citalopram Unstable medical condition (e.g., angina pectoris, untreated hypertension) Pregnant or nursing Woman of childbearing potential not using a medically acceptable form of birth control Actively suicidal or requiring hospitalization
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Healthy Therapeutic Equivalency Sex: Male or Female; similar proportions of each preferred Age: At least 18 years Weight: must be 15% of ideal weight for height and frame Subjects must be in good health and physical condition as determined by medical history Subjects must read and sign the Consent Form  history of treatment for alcoholism, substance abuse, or drug abuse within past 24 months history of malignancy, stroke, diabetes, cardiac, renal or liver disease history of GERD, malabsorption syndrome, colon cancer, or chronic colitis, including Crohn's disease history of treatment for asthma within the past five (5) years history of mental depression, pulmonary disease, sleep apnea females who are pregnant or lactating history of hypersensitivity to zolpidem tartrate, or any hypnotic or sedative conditions upon screening which might contraindicate or require that caution be used in the administration of zolpidem tartrate, including sitting systolic blood pressure below 90 mm Hg, or diastolic pressure below 50 mm Hg; heart rate less than 50 beats per minute after a 5-minute rest in a seated position inability to read and/or sign the consent form treatment with any other investigation drug during the four (4) weeks prior to the initial dosing for this study
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Bipolar Disorder Mania Key Clinical diagnosis of bipolar I disorder mania, manic or mixed episode, with or without psychotic features Current ongoing lithium or valproate treatment with the possibility of benefiting, based on the investigator's clinical judgment, from adjunctive treatment with aripiprazole Therapeutic serum levels of lithium or valproate and a Young Mania Rating Total Score of 16 or higher at screening and baseline Participants taking current lithium or valproate treatment combined with antipsychotic medication other than aripiprazole are acceptable, provided that the other antipsychotic medication is washed out at least 3 days prior to the blood draw for therapeutic plasma levels of lithium and valproate determination. Long-acting antipsychotics must be washed out prior to entering the double-blind treatment Key  Women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 4 weeks after the last dose of investigational product A diagnosis of delirium, dementia, amnesia or other cognitive disorder, or a psychotic disorder Current diagnosis of delirium, dementia, a cognitive disorder (ie, amnesia), or a psychotic disorder (ie, schizophrenia or schizoaffective disorder) Current diagnosis of bipolar II disorder, bipolar disorder not otherwise specified, or any other primary psychiatric disorder other than bipolar I disorder mania Thyroid pathology Demonstrated cocaine abuse or dependence within the past 3 months prior to screening History of neuroleptic malignant syndrome from antipsychotic agents Manic symptoms that investigator considers refractory to treatment Previous nonresponsive (by investigator judgment) to aripiprazole for manic symptoms Significant risk of suicide based on history, mental status exam, or investigator judgment
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Acute Mania in Bipolar Disorder Provision of written informed consent before initiation of any study related procedures. Patients who are deemed incapable of providing informed consent maybe enrolled if written informed consent has been obtained from the patient's Legally Authorized Representative Documented clinical diagnosis meeting the DSM-IV for any of the following 4X Bipolar I Disorder, Most Recent Episode Manic 0X Bipolar I Disorder, Single Manic Episode Have a YMRS score of at least 20 and a score of at least 4 on 2 of the following 4 YMRS items both at enrolment and at randomisation: Irritability, Speech, Content, and Disruptive/Aggressive Behaviour Female patients of childbearing potential must have a negative urine pregnancy test at enrolment and be willing to use a reliable method of birth control, i.e., barrier method, oral contraceptive, implant, dermal contraception, long-term injectable contraceptive, intrauterine device, or tubal ligation, during the study Be able to understand and comply with the requirements of the study, as judged by the investigator  Manic episode judged to be either the direct physiological consequence of a treatment or medical condition other than Bipolar disorder the direct physiological effect of a substance of abuse; intoxication with hallucinogens, inhalants, opioids, or phencyclidine and related substances the direct physiological effect of psychostimulant or antidepressant medication Evidence of clinically severe or active disease, or a clinical finding that is unstable or that, in the opinion of the investigator, would be negatively affected by the study medication or that would affect the study medication History of seizure disorder, except febrile convulsions Hospitalization period of 3 weeks or longer immediately prior to randomization for the index manic episode Known history of intolerance or hypersensitivity to quetiapine or lithium, or to any other component in the tablets/capsules Known lack of response to quetiapine or lithium, as judged by the investigator Use of antipsychotic medication or mood stabilizer other than quetiapine and lithium at the day of randomisation (to be tapered to discontinuation between the enrolment visit and randomisation)
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Healthy Sex: Male or Female; similar proportions of each preferred Age: At least 18 years Weight: must be 15% of ideal weight for height and frame Subjects must be in good health and physical condition as determined by medical history Subjects must read and sign the Consent Form  History of treatment for alcoholism, substance abuse, or drug abuse within past 24 months History of malignancy, stroke, diabetes, cardiac, renal or liver disease, or other serious illness History of GERD, malabsorption syndrome, colon cancer, or chronic colitis, including Crohn's disease History of treatment for asthma within the past five (5) years History of mental depression History of pulmonary disease History of sleep apnea Females who are pregnant or lactating History of hypersensitivity to zolpidem tartrate, or any hypnotic or sedative Treatment with any other investigational drug during the four weeks prior to the initial dosing of the study
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 12.0-39.0,  Schizophrenia Schizoaffective Disorder Schizophreniform; Bipolar I Disorder Bipolar II Bipolar NOS Psychotic Disorder Not Otherwise Specified Autism Children and adolescents ages 12-18 with a diagnosis of Schizophrenia, Schizoaffective Disorder, Schizophreniform, Bipolar I, Bipolar II, Bipolar NOS or Psychotic Disorder NOS Subjects must be on either Olanzapine, Seroquel, Clozapine or Risperdal for less than 6 weeks and have gained at least 2% of the body weight during that time  Subjects who have diabetes, hyper or hypothyroidism or other metabolic abnormalities Females who are pregnant or breast-feeding Diagnosis of asthma or peptic ulcer disease Antihypertensive agents, Metformin, lipid-lowering agents, thyroid r replacement therapy
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-55.0,  Methodology Study Age 18-55 BMI 18-30 kg/m2 body weight > 50 kg  no history of sleep disorder no concurrent medications no alcohol use no medical issues no smoking
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Bipolar Disorder Medically healthy Meets DSM-IV for bipolar disorder of any subtype No more than 32 weeks gestation, dated by last menstrual period  Active suicidality or homicidality Acute psychotic symptoms
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Bipolar I Disorder Male and female adult patients with bipolar 1 disorder and acute agitation  Agitation caused primarily by acute intoxication History of drug or alcohol dependence Treatment with benzodiazepines or other hypnotics within 4 hours prior to study drug administration
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Bipolar Disorder Age 18-65 male or female DSM -IV for bipolar I affective disorder Ability and willingness to sign informed consent for participation in the study  Unwillingness or inability to participate in the study
Patient description: A 26-year-old obese woman with a history of bipolar disorder complains that her recent struggles with her weight and eating have caused her to feel depressed. She states that she has recently had difficulty sleeping and feels excessively anxious and agitated. She also states that she has had thoughts of suicide. She often finds herself fidgety and unable to sit still for extended periods of time. Her family tells her that she is increasingly irritable. Her current medications include lithium carbonate and zolpidem.

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Spinal Cord Injury Subjects of either gender and 18-60 years of age Subjects with chromic spinal cord injury (defined as a history of spinal cord injury for 12 months or longer) Subjects with ASIA classification of A, B, or C for at least 6 months unchanged Spinal cord injury vertebral level should be between C4 and T10 Subjects must be able to read, understand, and complete the VAS Subjects who have voluntarily signed and dated an informed consent form, approved by an IRB/IEC, prior to any study specific procedures  A history of hypersensitivity or other adverse reaction to lithium Significant renal, cardiovascular, hepatic and psychiatric disease Significant medical diseases or infection Addison's disease Debilitation or dehydration Recently taken or are taking diuretics or other drugs with known interaction with lithium, such as tricyclic antidepressants, NSAIDs and tetracyclines A history of alcohol abuse or drug abuse Pregnant or lactating women Female of childbearing potential and are unwilling to use an effective contraceptive method while enrolled in the study Subjects who are currently participating in another investigational study or has been taking any investigational drug within the last 4 weeks prior to screening of this study