Patient description: A Pap smear in a 54-year-old woman revealed abnormal cervical squamous intraepithelial/glandular lesion. She tested positive for HPV 16. She is sexually active with her husband and has 4 children. She is menopausal and uses no contraception. She smokes and drinks alcohol frequently. She is otherwise healthy. She was offered conization.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Solid Tumor Diagnosis of locally advanced or systemic metastatic solid tumors with NTRK1/2/3 fusion gene; 2. Subjects who failed or refused to accept the standard treatment; 3. At least one measurable target tumor lesion as accessed by v1.1; 4. Subjects diagnosed with primary CNS tumors should meet the following (1) Received previous treatment, including radiotherapy, chemotherapy, targeted therapy; (2) At least one measurable lesion by two-dimensional measurement (confirmed by MRI and using RANO). At least one measurable lesion in each dimension should be ≥ 1cm and on more than one image; (3) The imaging exam should be completed within 28 days before dosing, and the disease should be in stable; 5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2. 6. Minimum life expectancy of 3 months; 7. Adequate organ function defined per protocol; 8. Coagulation function: international standardized ratio (INR) ≤ 1.5, and partial prothrombin time (PT) or activated partial prothrombin time (APTT) ≤ 1.5 × ULN (Upper limit of normal); 9. For patients enrolled via local molecular testing, an archival or fresh tumor tissue is required to be submitted for independent central molecular testing; 10. Any toxic effect caused by prior therapies must be recovered to CTCAE Grade ≤1 except for alopecia  Current participation in another therapeutic clinical trial within 4 weeks before first dose; 2. Prior treatment with NTRK fusion gene and immune checkpoint inhibitors (including PD-1/PD-L1, etc.); 3. Subjects with symptomatic or unstable brain metastasis (asymptomatic brain metastasis subjects can be selected for) and CNS primary tumor, but need to be in stable for at least 7 days, will be enrolled; 4. Had major surgery or radiotherapy within one month before the first dose, or were expected to need a major surgery during study; 5. Pneumonia caused by interstitial lung disease, interstitial fibrosis, or tyrosine kinase inhibitors; 6. Active and uncontrollable systemic bacterial, viral or fungal infectionsx; 7. Clinically active viral disease with positivity of serum HIV, HBV, HCV testing; 8. Historical immunodeficiency, including acquired, congenital immunodeficiency diseases, or a historical organ transplant; 9. The systematically use of strong CYP3A inhibitors, including ( but not limited to) atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin, voriconazole, grapefruit or grapefruit juice; 10. The systematically use of strong CYP3A inducers, including ( but not limited to) carbamazepine, phenobarbital, phenytoin, rifampicin, rifampicin and St. John's grass; 11. Any other anti-tumor drug use within 14 days before first dose or during the study; 12. Historical, neurological or mental disorders, such as epilepsy or dementia; 13. Historical drug abuse; 14. Spinal cord compression caused by tumor (unless the subject's pain is completely controlled and neurological function is stable or restored),cancerous meningitis or leptomeningeal disease; have risk of cerebral hernia determined by investigator; 15. Active gastrointestinal or other malabsorption disease, such as gastrectomy or enterectomy; 16. With 3 months before first dose, have unstable cardiovascular disease like as, myocardial infarction, severe / unstable angina pectoris, coronary artery / peripheral artery bypass grafting, congestive heart failure (NCICTCAEv5.0 ≥ 3), arrhythmia (NCICTCAEv5.0 ≥ 2), uncontrollable atrial fibrillation (arbitrary grade) or female QTcF > 470ms or male QTcF > 450ms; 17. Cerebrovascular accidents (exclude transient ischemic attacks) occurred within 3 months before first dose; 18. Other malignant tumors, cured non-melanoma skin cancer, cervical cancer in situ and prostatic intraepithelial neoplasia; 19. Other protocol specified accessed by investigator