Patient description: A 53-year-old man presents with chronic HCV infection for the past 2 years. His past medical history is only significant for inguinal hernia surgery when he was 20 years old. He is on IFN (100 mg/week) plus RBV (400 mg/day) combination therapy for the past 9 months. Direct antiviral drugs were added to his treatment 6 months ago. His medical record shows previous positive HCV RNA tests as well as positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hepatitis HIV/AIDS To be eligible for participation on this protocol, a participant must satisfy all of the following conditions: 1. Be greater than or equal to18 years old and have an identifiable primary care provider. 2. Have documented chronic HCV infection by demonstration of a positive test for hepatitis C antibody and HCV RNA of 2,000 IU/mL or greater. 3. Infected with HCV GT-1 virus. 4. If coinfected, have either documentation of HIV-1 infection by licensed enzyme-linked immunosorbent assay (ELISA) confirmed by a Western Blot or history of HIV RNA of 1,000 copies/mL or greater. 5. If coinfected, must meet one of the following prior to enrollment: 1. If on a stable non-NNRTI or non-PI antiretroviral regimen that HAS NOT changed within the past 6 months, must have an HIV-1 VL of less than 400 copies/mL for at least 3 months; or 2. If on a current antiretroviral regimen that HAS changed within the past 6 months, have an HIV-1 VL of less than 50 copies/mL for at least 3 months; or 3. Be a long-term nonprogressor as documented in the medica record. 6. Have histopathologic features consistent with chronic HCV infection at the time of enrollment. A liver biopsy within 3 years (36 calendar months) prior to screening may be used as the baseline biopsy. Participants can opt out of a liver biopsy if they had one more than 3 years prior and have a contraindication, such as receipt of chronic anticoagulation therapy. Participants with decompensated liver disease are excluded from the study. 7. Are na(SqrRoot) ve to prior IFN-based treatment for HCV. 8. Have CD4 cell counts greater than or equal to 100 cells/mm(3). 9. Willing to have genetic testing. 10. Not pregnant or breastfeeding. Serum pregnancy test must be negative at screening for female participants. 11. Agree not to become pregnant if a female of childbearing potential while on the study and for at least 6 months after stopping RBV. Because of the potential teratogenic effects of RBV treatment, subjects and their partners must remain abstinent or use two methods of birth control, which may be selected from the following list (oral contraceptive concentrations are decreased, and may not be effective when used during BOC treatment and, therefore, are not included in this list): Surgical sterilization of either partner Intrauterine device Male or female condoms with or without a spermicide Diaphragm, cervical cap, or sponge 12. Male participants who are not documented to be sterile must agree to either abstain from intercourse or consistently use a condom while their female partner (if applicable) agrees to use one of the appropriate medically accepted methods of birth control listed above from the date of screening until 6 months after the last dose of RBV. 13. Be able and willing to either learn to safely inject medication or find another person to inject the medication for him/her. 14. Be willing to allow storage of blood or tissue samples for future research. Co-enrollment Guidelines: Participants may be enrolled in other NIH protocols as long as the amount of research blood drawn does not exceed the acceptable NIH guidelines and the protocol does not other experimental therapies (including expanded access/compassionate use of HIV antiretrovirals)  A participant will be ineligible to participate on this study if any of the following are met: 1. Use of other experimental therapies (including expanded access/compassionate use of HIV antiretrovirals) within 30 days or 5 half-lives (whichever is longer), prior to enrollment. 2. Current use of an efavirenz-based (or other NNRTI) or protease inhibitor HIV antiretroviral regimen. 3. Use of any of the following medications within 6 weeks prior to enrollment. Alfuzosin (Uroxatral ) Alprazolam (Xanax ) Atorvastatin (Lipitor ) AZT or zidovudine (Retrovir ) Carbamazepine (Tegretol ) Cisapride (Propulsid ) Colchicine (Colcrys ) If patient has renal or hepatic impairment. DDI or didanosine (Videx ) d4T or stavudine (Zerit ) Delaviridine (Rescriptor ) Digoxin (Lanoxin ) Dihydroergotamine Drosperinone (Yaz ) Efavirenz (Sustiva ) Ergonovine (Ergotrate ) Ergotamine (Cafergot ) Etravirine (Intelence ) Ganciclovir (Cytovene ) Immunosuppressive therapy (including oral steroids) ---Use of any use of any immunosuppressive therapy, including systemic steroids (prednisone equivalent of greater than 10 mg/day) for a duration of 6 weeks or more within 6 months prior to enrollment. Use of inhaled/nasal steroids should be avoided. Isoniazid or INH (Ingredient in Rifater ) Ketoconazole (Nizoral ) Lovastatin (Mevacor ) Methylergonovine (Methergine ) Midazolam given orally (Versed ) Nevirapine (Viramune ) Phenobarbital (Luminal ) Phenytoin (Dilantin ) Pimozide (Orap ) Pyrazinamide (Ingredient in Rifater ) Rifabutin (Mycobutin ) Rifampin/rifampicin Rilpivirine (Edurant ) Sildenafil (Viagra ) Phosphodiesterase type 5 inhibitors are prohibited when used for pulmonary hypertension Simvistatin (Zocor ) St. Johns s Wort Tadalafil (Cialis ) Phosphodiesterase type 5 inhibitors are prohibited when used for pulmonary hypertension Thalidomide (Thalomid ) Theophylline (Slo-Phylllin ) Triazolam (Halcion ) Vardenafil (Levitra ) Phosphodiesterase type 5 inhibitors are prohibited when used for pulmonary hypertension Warfarin (Coumadin ) Zalcitabine (Hivid ) There may be other brand names for these products listed above. 4. Has ingested silymarin (milk thistle), s-adenosylmethionine (SAM-e), glycyrrhizin, Sho-saiko-to (SST), or other herbal supplements that may be either liver beneficial or toxic, within 28 days prior to enrollment. 5. Mixed HCV genotypes (e.g., 1 & 2, 1 & 3, 1 & 4) (mixed genotype 1a/1b can be included). 6. Has any other known, or clinically suspected, cause of liver disease, including active hepatitis B. 7. For participants with cirrhosis, a Child Turcotte Pugh score greater than 7, or Child s B or C cirrhosis. 8. Certain abnormal hematological and biochemical parameters, including: 1. Neutrophil count less than1000 cells/mm3 2. Hemoglobin less than10g/dL 3. Platelet count less than or equal to 50,000 cells/mm3 4. Estimated glomerular filtration rate less than50 mL/min/1.73 m(2), calculated automatically by the NIH lab using the original MDRD (modification of diet in renal disease) study equation 5. Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) greater than or equal to10 time ULN 6. Prothrombin time International Normalized Ratio (PT-INR) less than2 and/or on chronic anticoagulation medications 7. If total bilirubin is greater than 1.5 mg/dL, then direct bilirubin can be no more than 70% of the total, up to a direct bilirubin of 2.0 mg/dL. 9. Alpha-fetoprotein less than20 ng/mL, unless an ultrasound, computerized tomography scan (CT), or magnetic resonance imaging (MRI) has been performed to rule out hepatoma. 10. Hepatic mass suggestive of hepatocellular carcinoma as detected by ultrasound scan, dual-phase CT, or MRI. 11. History of esophageal or gastric varices. 12. Any neoplastic disease or any nonmetastatic skin, cervical, or anal cancer that has been resected in the past 5 years Kaposi s sarcoma not requiring systemic chemotherapy. 13. Prior organ transplantation other than cornea or hair. 14. Evidence of severe cardiac disease (greater than or equal to Grade 3 congestive cardiac failure, symptomatic coronary artery disease, significant arrhythmias, or uncontrolled hypertension) despite intervention or medical therapy. 15. Evidence of severe chronic pulmonary disease with functional impairment. 16. Severe psychiatric disorder that would interfere with adherence to protocol requirements, and that is not stably treated. 17. Evidence of autoimmune disorders including inflammatory bowel diseases, psoriasis, and optic neuritis. 18. Evidence of an uncontrolled seizure disorder defined as more than 1 episode of generalized seizure within the past year. 19. Chronic pancreatitis based on clinical history. 20. History of severe retinopathy. 21. History of hemophilia. 22. Any hemoglobinopathy (e.g., Thalassemia, sickle cell disease). 23. Active systemic infections other than HCV and HIV-1. 24. Evidence of gastrointestinal malabsorption, chronic nausea, or vomiting. 25. Has any systemic illness that will make it unlikely that the participant will be able to return for the required study visits. 26. Any condition that, in the opinion of the investigator, contraindicates participation in this protocol. of Children: Because there are insufficient data regarding the safety and efficacy of BOC, PEG, or RBV in the pediatric population, children are excluded from this study. of Women: Pregnancy: Pregnant women are excluded from this study because the effects of BOC, PEG, and RBV on the developing human fetus are unknown. Preclinical animal data indicate that the use of RBV treatment during pregnancy is potentially teratogenic. Breastfeeding: Because there is an unknown but potential risk for adverse effects in nursing infants secondary to treatment of the mother with BOC, PEG, or RBV, breastfeeding women are excluded from this study