Patient description: A 42-year-old healthy woman came to the clinic to have her flu shot in early October. She works in a rehab center and has no underlying disease. It's her first time getting the vaccine this year. She is married for 5 years and uses barrier methods of contraception. Her menstrual cycle is irregular. She does not smoke. She is not on any medications. She exercises regularly for 30 minutes a day at least 5 days a week. She has no history of allergies to any food or drugs. Her past surgical history is significant for tonsillectomy and she is otherwise healthy.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Influenza Subjects 18 to 59 years of age, or 60 years of age and older, mentally competent, who have signed an informed consent form after having received a detailed explanation of the study protocol; 2. Are in good health or have one or more stable (See footnote) medical conditions, as determined by: 1. Medical history, 2. Physical examination, 3. Clinical judgment of the medical investigator; 3. Are able to understand and comply with all study procedures and to complete study diaries, can be contacted, and will be available for study visits. 4. Subjects who experienced fever (defined as axillary temperature >38oC) within 3 days prior to Visit 1; 5. Subjects who are pregnant or breastfeeding; 6. Females of childbearing potential who refuse to use an acceptable method of birth control for a period of 56 days before and after each vaccination. Adequate contraception is defined as hormonal (e.g., oral, injection, transdermal patch, implant, cervical ring), barrier (e.g., condom with spermicide or diaphragm with spermicide), intrauterine device (e.g., IUD), monogamous relationship with vasectomised partner who has been vasectomised for 6 months or more prior to the subject's study entry, or abstain from heterosexual intercourse (e.g., through sexual orientation or religious or other beliefs about premarital intercourse); 7. Subjects with any serious disease, including: 1. cancer, 2. acute or progressive hepatic disease, 3. acute or progressive renal disease, 4. chronic pulmonary disease requiring home oxygen therapy, 5. active neurological disorder, 6. autoimmune disease (including rheumatoid arthritis); 8. Subjects for whom surgery is planned during the study period; 9. Subjects with a bleeding diathesis; 10. Subjects with hypersensitivity to eggs, chicken protein, chicken feathers, influenza viral protein, neomycin or kanamycin, or any other component of the study vaccine; 11. Subjects with a history of any neurological symptoms and signs, or anaphylactic shock following administration of any vaccine; 12. Subjects with known or suspected impairment/alteration of immune function, for example, resulting from: 1. receipt of oral immunosuppressive therapy (e.g., corticosteroid therapy or cancer chemotherapy) (long-term, inhaled steroids for asthma management is acceptable), 2. receipt of immunostimulants or interferon, 3. receipt of parenteral immunoglobulin preparation, blood products, and/or plasma derivatives within 3 months prior to Visits 1 (Day 1), 2 (Day 22), or 5 (Day 382), or planned during the full length of the study, 4. high risk from developing an immunocompromising disease; 13. Actual or planned receipt of another vaccine during the period 3 weeks before to 3 weeks after vaccination on Days 1, 22, and 382; 14. Subjects with a history of (or current) drug or alcohol abuse (20g/day for females; 30g/day for males) that in the investigator's opinion would interfere with safety of the subject or the evaluation of the study objectives; 15. Subjects who are unable to lead an independent life either physically or mentally; 16. Have participated in a previous study of H5 avian influenza vaccine; 17. Have been previously vaccinated with a vaccine containing MF59 or similar adjuvant; 18. Subjects with any condition, which, in the opinion of the Investigator, might interfere with the evaluation of the study objectives