Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 12.0-999.0,  Tinea Pedis Athlete's Foot Be at least 12 years of age and of either sex Have a clinical diagnosis of interdigital tinea pedis involving at least2 web spaces in total which extends no more than approximately 1 inch proximal to the web spaces or metatarsophalangeal joints with at least i) moderate scaling and ii) mild erythema defined as a Grade 2 and Grade 1, respectively on the Grading of Signs and Symptoms at baseline Be willing and able to give informed consent/assent or have their parent/guardian do so, if applicable Be willing and able to use the assigned study medication as directed and to commit to all follow-up visits for the duration of the study Have microscopic evidence (positive KOH) of the presence of fungi. Evaluable subjects must have a positive KOH and a fungal culture positive for a dermatophyte in the skin scrapings taken at the Baseline Visit. Subjects with a positive KOH may be entered into the study pending the results of the fungal culture Be in good health and free of any disease or physical condition which might, in the Investigator's opinion, expose the subject to an unacceptable risk by study participation Females must be non-pregnant (confirmed by a negative urine pregnancy test at baseline), non-lactating and not intending to become pregnant during the course of the study  Is pregnant, nursing or planning a pregnancy during the study Has used topical antifungals or topical corticosteroids on the feet within 30 days prior to the start of the study Has received systemic antifungal therapy within 12 weeks prior to the start of the study medication Has used systemic antibacterials or systemic corticosteroids within 30 days prior to the start of the study. Systemic corticosteroids do not intranasal, inhaled, and ophthalmic corticosteroids used for the management of allergies, pulmonary disorders or other conditions Has a history of uncontrolled diabetes mellitus or is immunocompromised (due to disease, e.g., HIV, or medications) Has concurrent tinea infection e.g. tinea versicolor, tinea cruris, moccasin-type tinea pedis, etc. (in the opinion of the Investigator) Onychomycosis, involving ≥ 20% of the area of either great toenail or involvement of more than five toenails in total Has any other skin disease which might interfere with the evaluation of tinea pedis Is currently enrolled in an investigational drug or device study Has received an investigational drug or treatment with an investigational device within 30 days prior to entering this study