Patient description: The patient is a 32-year-old obese woman who came to the clinic with weight concerns. She is 165 cm tall and her weight is 113 kg. She is complaining of sleep apnea, PCO and dissatisfaction with her body shape. She is a high-school teacher married for 5 years. She doesn't use any contraceptive methods for the past 4 months and she had no prior pregnancies. She doesn't smoke or use any drugs. She likes to try diets and exercise to lose weight. She completed the four square step test in 14 seconds. Her BP: 130/80, HR: 195/min and her BMI is: 41.54. Her labs: FBS: 98 mg/dl TG: 150 mg/dl Cholesterol: 180 mg/dl LDL: 90 mg/dl HDL: 35 mg/dl Her cardiac assessment is normal. Her joints and ROM are within normal.

Clinical trial eligibility criteria: eligible ages (years): 22.0-65.0,  Obesity Male and female patients age ≥ 22 years and < 65 years old with a BMI of ≥ 50 kg/m2. 2. Failure of bariatric surgery (gastric bypass) and subjects who have no endoscopically or surgically correctable causes for failed bariatric surgery. "Failed bariatric surgery" is determined using the modified Reinhold classification as patients who are currently more than 50% over ideal body weight at least 24 months after a technically successful surgery (as confirmed by a esophagogastroduodenoscopy (EGD) within the 6 months prior to ICF). 3. Stable at their present weight (+/ kg) for a 12-month period. 4. Neuropsychiatric evaluation must not reveal any issues that will be an impediment to subject's participation (as listed in  3 and 4). 5. Karnofsky Performance Score >60. 6. Platelet count >125,000 per cubic mm. 7. Prothrombin time (PT) and partial thromboplastin time (PTT) within normal limits Any intracranial abnormality or medical condition that would contraindicate DBS surgery. 2. Have a history that includes a prior suicide attempt. 3. Have any significant psychiatric condition likely to compromise the subject's ability to comply with requirements of the study protocol (e.g. bipolar, schizophrenia, mood disorder with psychotic features, cluster B personality disorders) or have any prior history of schizophrenia or bipolar disorder or active psychotic episodes. 4. Have a current diagnosis of major depressive episode per DSM-IV (Diagnostics and Statistical Manual of Mental Disorders) or has a current BDI-II score ≥ 17. 5. Any current drug or alcohol abuse, per DSM-IV or any history of substance abuse (alcohol or other drug) or dependence during the past 12 months. 6. Any history of recurrent or unprovoked seizures. 7. Any history of hemorrhagic stroke. 8. Any diagnosis of acute myocardial infarction or cardiac arrest within previous 6 months. 9. Any diagnosis of a neurological disorder, such as multiple sclerosis, stroke, Parkinson's disease, severe brain atrophy or the presence of subdural hygromas or subdural hematomas. 10. Any history of hypothyroidism. 11. Any history of demonstrated binge eating. 12. Concurrent use of weight-loss prescription drug therapy or the use of over-the-counter weight loss preparations. 13. Any prior intracranial surgery or device implantation. 14. Any other active implanted devices (e.g., spinal cord stimulator, cochlear implant, pacemaker, vagus nerve stimulator) and /or drug delivery pumps, whether turned on or off. Passive implants (e.g., knee prostheses) would be allowed provided that they would not interfere with the DBS. 15. Any previously implanted Vagus Nerve Stimulation (VNS) patients. 16. A condition requiring or likely to require the use of Magnetic Resonance Imaging (MRI), diathermy or electroconvulsive therapy (ECT). 17. Likely to require the use of monopolar cautery, radio-frequency (RF) procedures, external defibrillation, lithotripsy, radiation therapy or transcranial stimulation. 18. Currently on any anticoagulant medications that cannot be discontinued during perioperative period. 19. Have any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints, (e.g. hepatitis or HIV). 20. Any terminal illness with life expectancy of < 1 year. 21. Any diagnosis of malignancy (except basal cell of skin) within the past five years. 22. Any unresolved infection, a coagulopathy or significant cardiac or other medical risk factor for surgery. 23. Current or future risk of being immunocompromised (due to medications, disease factors, illness, etc.) that might significantly increase risk of infection. 24. Participation in any other clinical trial (e.g. drug, device, or biologics) concurrently or within the preceding 30 days. Participation in any other study will be allowed per investigator/sponsor discretion only. 25. Plan to receive any procedure that involves sudden jerking motions of the head or neck (e.g. certain chiropractic therapies) or massage and manipulation directly over the leads in the scalp, neck or chest, at any time during the study. 26. A female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception. 27. Not able to speak, write and read in English language as determined by the investigator. 28. Overall intellectual abilities below a standard score of 80 based on results from the Wechsler Abbreviated Scale of Intelligence (WASI; Wechsler, 1999) 29. Unable to fit into MRI or CT (Maximum weight limit is 180 kg (396 lb.). 30. Plasma pre-albumin < 14 mg/dL 31. Obesity as part of another medical condition, neurological injury or lesions, related to medication side effect, or as part of a genetic syndrome (i.e. Prader-Willi Syndrome, Leptin deficiency, etc.) 32. Be eligible for bariatric surgery revision including gastric outlet gastrogastric fistula or other reasons that would qualify for a revision of their gastric bypass 33. Unable or unwilling to follow up for scheduled clinic visits