semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Essential Tremor Consenting male and female participants Diagnosis of 'definite essential tremor' in accordance with the TRIG including: ET individuals diagnosed with upper limb tremor in their motor dominant and non-dominant hands Stable ET medication management for the 3 month duration prior to their enrollment in the study Participants who are botulinum toxin naïve for tremor management Patients will be screened for pregnancy by the physician  History of stroke Muscle weakness or any related compartmental muscle syndrome Smoking History of ALS or Myasthenia Gravis Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic agonists (e.g. salbutamol) Persons prescribed zonisamide History of allergic or side effect reaction to botulinum toxin Contraindications per the Xeomin® drug monograph Women reporting that they are pregnant
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Severe Dystonia Wilson's Disease Age > 18 and < 60 years Severe neurological form of Wilson's disease with predominant dystonia and akinetic-rigid syndrome, despite optimized treatment stabilized for at least 6 months Important disability due to abnormal movements (Rankin score=2 to 4) Absence of dementia (MMS > 24 and BREF > 15) Stable psychiatric status and absence of severe depression (BDI <28) Social security coverage Signature of informed consent. (signature of legal guardian for subjects under protection)  Severe hepatopathy with coagulation disorders (Platelet count < 100 G / l; INR > 1.5; V factor deficit; low level of fibrinogen < 1g/dL; increased of fibrin degradation products; low level of antithrombin) Liver transplanted patients < 2 years Patients under immunosupressive drugs and corticoids regimen Participation to another biomedical research involving any drugs Severe and uncontrolled psychosis or depression Major atrophy on brain MRI that could represent a problem for leads implantation Necrosis of the STN/GPi on brain MRI Female subjects who are pregnant or lactating
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Cataract Macular Degeneration Glaucoma Patient at the Atlanta VA Medical Center (VAMC) New Comprehensive eye clinic  Known acute or chronic ocular issues
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 1.0-7.0,  Neurofibromatosis Type 1 Patient must be seen at the St. Louis Children's Hospital NF Clinic Diagnosis of NF1 Between 1 and 7 years of age, inclusive Diagnosed with hypotonia Legally authorized representative/guardian must be able to understand and willing to sign an IRB-approved informed consent document Must have an MRI scan ordered by a treating physician  Normal tone on clinical exam Known allergy to gadolinium or the sedative, propofol, used during MRI Poor kidney function defined as a known renal disease or elevated BUN and creatine Requiring intubation for anesthesia
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Tremor, Limb Patients affected by severe upper limb tremor refractory to medical therapy and who are less than optimal candidate for a deep brain stimulation (DBS) procedure Age ≥ 18 years old Refusal of DBS procedure Written consent  Pregnancy CT/MRI contraindication Illiteracy
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Knee Osteoarthritis Age 18 and up undergoing a total knee replacement with single surgeon. American Society of Anesthesiologists Physical Status Classification Scale (ASA) 1-3  Allergy to local anesthestic, pre-existing peripheral neuropathy, revision surgery
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-2.0,  Adverse Reaction to Drug Allergic Reaction to Contrast Media Any patient under 2 years of age undergoing an MRI exam of the neuraxis or body with or without and with contrast as part of their standard of care Included patients may be scheduled with simultaneous sedation for the MRI Nonsedated patients also qualify for the study  Patients 2 years of age or older Patients receiving an MRI exam without contrast Patients with a GFR <30 Patients with known renal failure or prior gadolinium based contrast agent hypersensitivity reaction Patients who receive an MRI exam using a different gadolinium-based contrast agent Patients who are not accompanied by a parent will not be included Patients who are unable to complete the MRI exam prior to contrast administration will be excluded
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-90.0,  Multiple Sclerosis Men and women, age 18 years and older Patients who are able and willing to give informed consent and able to attend all study visits Patients with a diagnosis of Multiple sclerosis (MS) as confirmed from clinical history and examination by a neurologist The patient must have disabling tremor from MS as indicated by a score of at least 2 on the Tremor Rating Scale (TRS) baseline global assessments by the examiner and the patient. Or Disabling is defined as significant impairment of the normal functions of daily life as indicated by a score of at least 5 on the Clinical Global Impression (CGI)-Severity scale.or ETRS The MS patient must have disabling and medically refractory unilateral or bilateral upper extremity tremor. Patients with associated ipsilateral lower extremity tremor are not excluded The patient must have a history of an unsatisfactory response to medical management. Any patient will need to have tried and failed at least one drug. Alternatively, a patient may also qualify if tremor-suppressing medications are contraindicated due to a coexisting medical condition or drug allergy Patients should be on a stable dose of medications for 30 days prior to study entry  Subjects with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including cardiac pacemakers, size limitations, etc Significant claustrophobia Subjects who are not able or willing to tolerate the required prolonged stationary supine position during treatment Subjects with unstable cardiac status Severe hypertension Current medical condition resulting in abnormal bleeding and/or coagulopathy Receiving anticoagulant (e.g. warfarin) or antiplatelet (e.g. aspirin) therapy within two weeks of focused ultrasound procedure or drugs known to increase risk or hemorrhage History of intracranial hemorrhage History of multiple strokes, or a stroke within past 6 months Subjects with a history of seizures within the past year
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hepatitis C HIV Male and females ≥18 years Documented HIV infection Evidence of infection with hepatitis C virus (all genotypes): Positive anti-HCV antibody and HCV RNA Absence of advanced liver disease or clinical signs of extra-hepatic disease F0-F2 (< 9,5 kPa) established by transient elastography, and No clinical signs of extra-hepatic disease Not on HCV antiviral treatment  Currently on/or history of hepatitis C treatment Patients with initial fibrosis stage ≥ F3 (≥ 9,5 kPA on transient elastography) Patients not able/willing to adhere to the consultation, laboratory and liver stiffness measurement testing schedule as proposed in this study
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 22.0-999.0,  Essential Tremor 22 years or older 2. A diagnosis of essential tremor as confirmed from clinical history and examination by a movement disorder neurologist 3. Signed informed consent 4. At least one hand exhibiting kinetic tremor ≥ 2 as assessed by the Archimedes spiral task completed during the baseline evaluation, as assessed by the Investigator in-person. 5. Score of 3 or above in any one of the items of the Bain & Findley ADL Scale  Implanted electrical medical device, such as a pacemaker, defibrillator, or deep brain stimulator 2. Previous thalamotomy procedure, including Stereotactic Thalamotomy, Gamma Knife Radiosurgical Thalamotomy, and focused ultrasound, for the treatment of tremor 3. Suspected or diagnosed epilepsy or other seizure disorder 4. Pregnant 5. Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site 6. Peripheral neuropathy affecting the tested upper extremity 7. Alcoholism (score of 4 or higher on DSM-5) 8. Other possible causes of tremor, including Parkinson's disease, drug-induced, enhanced physiological tremor, dystonia 9. Other neurodegenerative disease like Parkinson-plus syndromes suspected on neurological examination. These multisystem atrophy, progressive supranuclear palsy, dementia with Lewy bodies, and cortical basal ganglionic degeneration 10. Changes in medication for tremor within 1 month prior to study enrollment 11. Change in antidepressant medication within 3 months prior to study enrollment 12. Botulinum Toxin injection for hand tremor within 6 months prior to study enrollment 13. Current participation in any other interventional research study 14. Previous participation in any other Cala Health interventional research study 15. Alcohol or caffeine consumption within 12 hours of study enrollment Subjects already taking medications for their essential tremor will remain on their medications during the study with no changes in medication type or dosage levels
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Tremor Adults Individuals who have undergone or are scheduled to undergo Deep Brain Stimulation (DBS) placement  Individuals who have not had or are not scheduled for Deep Brain Stimulation (DBS) placement
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Parkinson's Disease PD individuals diagnosed by UK Brain Bank with stage H&Y2-3 disease PD participants who are naïve to PD medications will be grouped into the "De novo" PD group PD participants stable on a low dose of Levodopa or on their PD medications for at least 3 months prior to their study enrolment will be grouped into the "L-dopa" PD group Participants who are botulinum toxin naïve for tremor management Patients will be screened for pregnancy by the physician Individuals with PD will be eligible for the study only if tremor is their primary and most bothersome symptom as determined by clinical exam and patient report denoting tremor-dominant phenotype Participants must be able to provide informed consent and to complete all study assessment scales and tasks  History of stroke History of ALS or Myasthenia Gravis History of COPD or emphysema Underlying arm muscle weakness or any related compartmental muscle syndrome Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic agonists (e.g. salbutamol) Persons prescribed zonisamide History of allergic or side effect reaction to botulinum toxin Contraindications per the BoNT-A drug monograph Women reporting that they are pregnant
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Essential Tremor Idiopathic Parkinson's Disease as defined by the UK brain bank and history of resting tremor, or Essential Tremor with history of resting tremor. Diagnosis made by a movement disorder specialist Midstage in disease process for Parkinson's disease with history of resting tremor  Dementia as defined by a mini-mental state examination cutoff score of 27 Atypical Parkinsonism Akinesia/ rigidity Parkinson's Disease Movement Disorders Stiff-Person syndrome, choreatic disease, dystonia, progressive supranuclear palsy Motor neuron disease Multiple sclerosis, amyotrophic lateral sclerosis, motor neuritis, progressive bulbar palsy, progressive muscular atrophy, spinal muscular atrophy Significant neurological comorbidities Stroke Brain cancer or brain metastases
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 20.0-29.0,  Flaccid Muscle Tone men 20-29 yrs BMI between 20 and 34.9 Fasting Glucose <110 mg/dL Blood Pressure <160/100mm Hg Non-Diabetic LDL-Cholesterol <160mg/dL Triacylglycerol <400 mg/dL Makers of kidney, liver, and heart functions within 10% of clinical normalcy <1.5hr /wk of habitual aerobic exercise training and no resistance exercise training in the past 6 months  men <20or>29 yrs BMI between <20 and >34.9 Fasting Glucose >110 mg/dL Blood Pressure >160/100mm Hg Non-Diabetic LDL-Cholesterol >160mg/dL Triacylglycerol >400 mg/dL Pre-existing kidney or liver conditions -->1.5hr /wk of habitual aerobic exercise training and no resistance exercise training in the past 6 months Currently taking prescribed blood thinners