Patient description: 19 yo Hispanic female G1P1 at 32+ 6 weeks of gestational age presented to the OB clinic for routine follow up complaining of mild headache and leg swelling. Primary evaluation revealed BP of 146/99 and urine dipstick with 3+ proteins. Her BP and U/A were normal in previous visit. Repeat BP a few hours later is 150/100 mmHg. Laboratory studies showed a normal hematocrit, platelet count, and liver transaminase levels. She is complaining of fatigue but no fever or chills. She is also suffering of headaches with no vision changes. No shortness of breath, cough, chest pain, orthopnea and palpitations or skin rash were observed. Her physical exam was negative for abdominal pain, change in bowel habits, nausea, vomiting, dysuria, frequency, hematuria or frothy urine. Leg swelling was observed with no arthralgia or back pain. She has no specific past medical issues and only uses prenatal vitamins. Her family history is positive for DM type 2 and HTN. She is a social alcohol consumer with the negative history of smoking or drug use. She is only have one partner in past 2 years and didn't have any contraceptive methods since 2 years ago. Her BMI was 24 at the first

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Cluster Headache Informed and written consent. 2. Male or female, 18-85 years of age 3. Headache attacks fulfilling the International Classification of Headache Disorders (ICHD) III for chronic cluster headache (CCH) 3.1.2. 4. Dominant headache laterality with ≥ 80% of cluster headache attacks on one side. 5. Subject reports ≥ 8 cluster attacks/week on the side of their dominant headache laterality in the 3 months prior to and in the baseline period. 6. The condition is pharmacologically refractory defined as suboptimal effect or intolerable side effects or contraindication for verapamil or lithium or suboccipital steroid injection. 7. Subject agrees to maintain current preventive headache medication regimens (no change in type, frequency, or dose) during the whole study period. 8. Subject is able to differentiate concomitant headaches from cluster headache. 9. In case of women of childbearing potential (WOCBP) they have to be using highly effective contraception in a period of 4 weeks after injection. 10. Ability to understand study procedures and to comply with them for the entire length of the study  Subject has had a change in type, dosage or dose frequency of preventive headache medications < 1 months prior to baseline/screening or 5 half-lives, whichever is longer.1 2. Subject has had a change in type, dosage or dose frequency of preventive headache medications during the baseline period, eg. prior to IMP administration. 3. Non-responder to both oxygen and triptan. 4. Non-responder in regular clinical practice at the discretion of the investigator to ≥4 of the listed preventive medications 1. Verapamil 2. Lithium 3. Topiramate 4. Valproate 5. Greater occipital nerve (GON) block 6. CGRP-antagonist 5. Participation in a clinical study of a new chemical entity or a prescription medicine within 2 months before study drug administration or 5 half-lives, whichever is longer. 6. Subject is currently participating or has participated in the last 3 months in another clinical study in which the subject has, is, or will be exposed to an investigational or non-investigational drug or device. 7. Allergy or hypersensitivity reactions to marcaine, lidocaine, xylocaine, adrenaline, any botulinum toxin or similar substances. 8. Abuse of drugs or alcohol. 9. Use of opioids for ≥10 days per month. 10. Treatment with pharmacological substances that may interact with BTA (aminoglycosides, spectinomycin, neuromuscular blockers, both depolarizing agents (such as succinylcholine) or non-depolarizing (tubocurarine derivates), lincosamides, polymyxins, quinidine, magnesium sulfate or anticholinesterases.). 11. WOCBP that do not adhere to the requirements for HEC, as noted in 9 and outlined in section 3.3. 12. Pregnancy or breastfeeding in the study period 13. Subject has undergone facial surgery in the area of the pterygopalatine fossa or zygomaticomaxillary buttress ipsilateral to the planned injection site that, in the opinion of the Investigator, may lead to an inability to properly conduct the procedure. 14. Facial anomaly or trauma which renders the procedure difficult.2 15. Subject currently has an active oral or dental abscess or a local infection at the site of injection based on present symptoms. 16. Subject has been diagnosed with any major infectious processes such as osteomyelitis, or primary or secondary malignancies involving the face that have been active or required treatment in the past 6 months. 17. Patients exhibiting a high degree of comorbidity and/or frailty associated with reduced life expectancy or high likelihood of hospitalization, at the discretion of the investigator. 18. Patients with comorbid psychiatric disorders with psychotic or other symptoms making compliance with the study protocol difficult, at the discretion of the investigator. 19. Patient with active infectious disease or infections that warrants special infection control measures, such as human immunodeficiency virus, tuberculosis, or chronic hepatitis B or C infection. 20. Patient with disorders that are known contraindication for Botox® treatment, especially neuromuscular disorders such as motorneuron disorders and myasthenic syndromes 21. Subject has had previous radiofrequency ablation, balloon compression, gamma knife, or chemical denervation (e.g. glycerol treatments) of the ipsilateral trigeminal ganglion or any branch of the trigeminal nerve. 22. Subject has had previous radiofrequency ablation (including non-lesional pulsed radiofrequency), balloon compression, gamma knife, or chemical denervation (e.g. glycerol treatments) of the ipsilateral SPG. 23. Subject is currently or has been previously treated with occipital nerve stimulation or deep brain stimulation. 24. Subject has had blocks of short-acting anaesthetics of the ipsilateral SPG in the last 3 months. 25. Subject has undergone onabotulinumtoxinA injections of the head and/or neck or has had an occipital nerve block in the last 3 months. 26. Subject is anticipated to require any excluded medication, device, or procedure during the study. 27. Subject has a history of bleeding disorders and in the opinion of the Investigator, may lead to an inability to properly conduct the procedure. 28. Subject has a history of coagulopathy. 29. Subject is unable to stop antithrombotic medication, eg. anticoagulants and/or antiplatelet therapy, before procedure. 30. The subject has been diagnosed with another trigeminal autonomic cephalalgia or trigeminal neuralgia. 31. The patient cannot participate or successfully complete the study, in the opinion of their healthcare provider or the investigator, for any of the following reasons mentally or legally incapacitated or unable to give consent for any reason in custody due to an administrative or a legal decision, under tutelage, or being admitted to a sanatorium or social institution. 32. The patient is a study centre employee who is directly involved in the study or the relative of such an employee