Patient description: The patient is a 47-year-old Asian woman complaining of persistent feelings of sadness. She lost interest in activities she used to enjoy. She states that her mood is mostly depressed for the past 3 weeks. She also lost her appetite , which led to about 5kg weight loss. She complains of loss of energy and feelings of worthlessness nearly every day. She is not using any drugs and she does not smoke. She doesn't drink alcohol. She used to exercise every day for at least 30 min. But she doesn't have enough energy to do so for the past 3 weeks. She also has some digestive issues recently. She is married and has 4 children. She is menopausal. Her husband was recently diagnosed with colon cancer and he is starting his chemotherapy. There is nothing remarkable in her past medical history and her drug history is only positive for Vit D3 1000 units daily. Her family history is negative for any psychologic problems. Her HAM-D score is 20.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Traumatic Brain Injury Fatigue Cognitive Impairment mTBI 1. Male or female with a diagnosis of mild TBI. 2. At least 6-month post-injury. 3. Ages 18 to 70 years. 4. Lives in same household as paired control that meets inclusion/   5. Participant is willing and able to give informed consent for participation in the study. mTBI Unable to walk unassisted. 2. Significant heart, liver, kidney, blood or respiratory disease. 3. History of chest pain or coronary heart disease. 4. Uncontrolled Diabetes mellitus. 5. Any history of a recently (12 months) diagnosed cancer other than a skin cancer (excluding melanoma). 6. Recent (within 6 months) treatment with anabolic steroids or corticosteroids. 7. Current alcohol or drug abuse. 8. Premorbid history of psychiatric disorder. 9. Premorbid history of head trauma. 10. Pregnancy or become pregnant during the trial. 11. Coumadin because of the risk of bleeding with daily injections of rhGH. 12. Subjects who are deficient in cortisol or thyroid at screening will be excluded until hormone abnormalities have been corrected. 13. Subjects with chronic pain who are being managed with narcotics will be excluded as the effects of central nervous system depressants may interfere with study test results. 14. Subjects with a history of inflammatory bowel disease, Celiac disease or active diverticular disease. 15. Subjects with a history of oral or IV antibiotics within the past 3 months. Household Control 1. Ages 18 to 70 years. 2. Lives in same household as paired mTBI subject that meets inclusion/exclusion criteria. 3. Participant is willing and able to give informed consent for participation in the study. Household Control Significant heart, liver, kidney, blood or respiratory disease. 2. Uncontrolled Diabetes mellitus. 3. Any history of a recently (12 months) diagnosed cancer other than a skin cancer (excluding melanoma). 4. Recent (within 6 months) treatment with anabolic steroids or corticosteroids. 5. Current alcohol or drug abuse. 6. Premorbid history of psychiatric disorder. 7. Premorbid history of head trauma. 8. Pregnancy or become pregnant during the trial. 9. Subjects who are deficient in thyroid at screening will be excluded until thyroid hormone is replaced. 10. Subjects with a history of inflammatory bowel disease, Celiac disease or active diverticular disease. 11. Subjects with a history of oral or IV antibiotics within the past 3 months