Patient description: The patient is a 45-year-old postmenopausal woman with cytologically confirmed breast cancer. A core biopsy revealed a 3 cm invasive ductal breast carcinoma in the left upper outer quadrant. The tumor is HER2-positive and ER/PR negative. Axillary sampling revealed 5 positive lymph nodes. CXR was remarkable for metastatic lesions. The patient is using multivitamins and iron supplements. She does not smoke or consume alcohol. She is not sexually active and has no children. She is a candidate for tumor resection and agrees to do so prior to chemotherapy.

Clinical trial eligibility criteria: eligible ages (years): 22.0-75.0,  Essential Tremor Subjects who: 1. previously underwent Exablate thalamotomy for their essential tremor in a clinical study or in a commercial procedure at least 9 months prior to enrolling in this study for contralateral Exablate thalamotomy 2. Subjects who would benefit from a bilateral treatment for their essential tremor and would want to undergo a staged bilateral thalamotomy 2. All subjects must have a complete baseline CRST prior from first Exablate thalamotomy 3. Men and women age 22 years to 75 years of age. 4. Minimum score of 24 on MoCA or 20 on MMSE 5. Subjects who are able and willing to give consent and able to attend all study visits 6. Postural or intention tremor severity score of greater than or equal to 2 in the both upper extremities as measured by the CRST rating scale while on stable medication 7. Thalamus can be targeted by the Exablate device. The region must be apparent on MRI such that targeting can be performed. 8. Able to communicate sensations during the Exablate Thalamotomy treatment 9. Original (before first Exablate procedure) CRST score of 2 or above in any one of the items 16-23 from the Disability subsection of the CRST: speaking, feeding other than liquids, bringing liquids to mouth, hygiene, dressing, writing, working, and social activities. 10. Subjects on antidepressant medications must be stable for at least 3 months prior to procedure(i.e., no change in medication drug or dosage for 3 months based on historical medical records). 11. Remains eligible for Exablate treatment with no changes to medical history that would affect Exablate treatment (e.g., bleeding/coagulation requirements, or new pathology such as infarct, tumor, etc)  Subjects with unstable cardiac status 2. Subjects exhibiting any behavior(s) consistent with ethanol or substance abuse as defined by the outlined in the DSM-IV as manifested by one (or more) of the following occurring within a 12 month period: 3. Subjects with uncontrollable blood pressure (hypertensive with diastolic BP > 100 on medication) 4. History of abnormal bleeding and/or coagulopathy, i.e. subjects with risk factors for intraoperative or postoperative bleeding as indicated by: platelet count less than 100,000 per cubic millimeter, a documented clinical coagulopathy, or INR coagulation studies exceeding the institution's laboratory standard 5. Receiving anticoagulant (e.g. warfarin) or antiplatelet (e.g. aspirin) therapy within one week of focused ultrasound procedure or drugs known to increase risk or hemorrhage (e.g. Avastin) within one month of focused ultrasound procedure 6. Active or suspected acute or chronic uncontrolled infection 7. Individuals who are not able or willing to tolerate the required prolonged stationary supine position during treatment (can be up to 4 hrs of total table time.) 8. Subjects with life-threatening systemic disease that but not limited to the following will be excluded from the study participation: HIV, Liver Failure, blood dyscrasias, etc... 9. Any clinically significant moderate to severe sensory deficit lasting greater than 30 days after the first Exablate thalamotomy NOTE: Subjects with clinically significant moderate to severe sensory deficit following first Exablate thalamatomy should be excluded even if event resolves within a few months of treatment. This may cause new first thalamotomy subjects to be ineligible for the bilaterally staged treatment. 10. Moderate to severe cerebellar disturbance (imbalance or ataxia) or presence of moderate or severe hemiparesis NOTE: Subjects with moderate to severe cerebellar disturbance (imbalance or ataxia) or presence of moderate or severe hemiparesis following first Exablate thalamatomy should be excluded even if event resolves within a few months of treatment. This may cause new first thalamotomy subjects to be ineligible for the bilaterally staged treatment. 11. Any persistent dysphasia/dysarthria, language impairment following first Exablate thalamotomy. NOTE: Subjects with significant impairment following first Exablate thalamotomy should be excluded even if event resolves within a few months of treatment. This may cause new first thalamotomy subjects to be ineligible for the bilaterally staged treatment. 12. Significant reduction in cognitive function since the first thalamotomy. NOTE: Subjects with significant reduction in cognitive function following first Exablate thalamatomy should also be excluded even if event resolves within a few months of treatment. This may cause new first thalamotomy subjects to be not eligible for the bilaterally staged treatment. 13. Subject is pregnant or breastfeeding. 14. Subjects who have an overall Skull Density Ratio of less than 0.40 as calculated at screening