Patient description: A 53-year-old man presents with chronic HCV infection for the past 2 years. His past medical history is only significant for inguinal hernia surgery when he was 20 years old. He is on IFN (100 mg/week) plus RBV (400 mg/day) combination therapy for the past 9 months. Direct antiviral drugs were added to his treatment 6 months ago. His medical record shows previous positive HCV RNA tests as well as positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Hepatitis C Male or female between the ages of 18 and 65 years 2. Chronic hepatitis C virus (HCV) genotype 1 infection 3. HCV RNA level >10,000 IU/mL 4. Chronic HCV infection, defined as Previous documentation of positive HCV serology (HCV antibody or RNA) at least 6 months (24 weeks) previously, or Positive HCV serology (HCV antibody or RNA) with a prior remote (more than 6 months previously) risk factor for acquisition of HCV or Historical biopsy consistent with chronic HCV infection 5. No clinically significant abnormalities in hematology, coagulation, or chemistry variables Hemoglobin >12 g/dL for women; >13 g/dL for men Total white cell count >3000/mm3 and absolute neutrophil count >1500/mm3 Platelets >100,000/mm3 Prothrombin time (PT) and/or international normalized ratio (INR) less than or equal to 1.2 times the local upper limit of normal (ULN) Conjugated (direct) bilirubin less than or equal to 1.5 times the ULN Serum creatinine within normal limits  Previous interferon-based antiviral therapy for chronic HCV infection 2. Previous treatment with known immunogenic drugs 3. Concomitant human immunodeficiency (HIV) or hepatitis B virus (HBV) infection 4. Cause of liver disease other than chronic HCV infection, such as autoimmune or alcoholic liver disease 5. Decompensated clinical liver disease, including a history of encephalopathy, bleeding esophageal or gastric varices, or ascites 6. Recipient of liver or other solid-organ transplantation 7. Evidence of clinically significant bleeding, defined as gross hematuria, hemoptysis, or gastrointestinal bleeding 8. History of bleeding diathesis or coagulopathy (eg, von Willebrand disease or hemophilia) 9. History of thromboembolic events (eg, deep-vein thrombosis [DVT] or pulmonary embolism). Previous central venous catheter-related thrombosis is acceptable if there is resolution recorded at least 12 months before enrollment. 10. Requirement for concurrent treatment with oral or parenteral anticoagulants or hormones (estrogen-containing contraceptives, hormone replacement, antiestrogen agents, progestins) 11. Condition requiring daily therapy with antiplatelet agents (eg, thienopyridines, dipyridamole, cilostazol; cardiovascular prophylaxis with aspirin is allowed) or corticosteroids 12. Investigational therapy within 28 days before the first planned dose of study drug 13. Major surgery within 28 days before the first planned dose of study drug 14. Uncontrolled intercurrent disease (eg, diabetes, hypertension, thyroid disease) 15. Ongoing angina pectoris or other symptoms of coronary artery disease (CAD); history of stroke, or transient ischemic attack (TIA) 16. History of suicidal ideation or attempt 17. Condition requiring treatment (past or current) with coumarin-type agents 18. Cardiac arrhythmia requiring medical therapy 19. Serious nonhealing wound (including wound healing by secondary intention, ulcer, or bone fracture) 20. Cancer, autoimmune disease, or any disease or concurrent therapy known to cause significant alteration in immune function (corticosteroids are allowed before study enrollment and during the study to treat an AE) 21. Female patients and female partners of male patients: pregnancy, lactation, or inability/unwillingness to practice effective contraception