Patient description: A 39-year-old man came to the clinic with cough and shortness of breath that was not relieved by his inhaler. He had these symptoms for 5 days during the past 2 weeks. He doubled his oral corticosteroids in the past week. He is a chef with a history of asthma for 3 years, suffering from frequent cough, wheezing, and shortness of breath and chest tightness. The symptoms become more bothersome within 1-2 hours of starting work every day and worsen throughout the work week. His symptoms improve within 1-2 hours outside the workplace. Spirometry was performed revealing a forced expiratory volume in the first second (FEV1) of 63% of the predicted. His past medical history is significant for seasonal allergic rhinitis in the summer. He doesn't smoke or use illicit drugs. His family history is significant for asthma in his father and sister. He currently uses inhaled corticosteroid (ICS) and fluticasone 500 mcg/salmeterol 50 mcg, one puff twice daily.

Clinical trial eligibility criteria: eligible ages (years): 18.0-64.0,  Atopic Asthma Age 18 to 64 years (inclusive). 2. Male or female. 3. If male, is surgically sterile (vasectomy) or agrees to comply with required contraceptive measures. 4. If female, not pregnant (or lactating), as evidenced by a negative serum pregnancy test, and is either surgically sterile (hysterectomy, bilateral ovariectomy, or bilateral tubal ligation), or if a female of childbearing potential, agrees to comply with required contraceptive measures. 5. History of episodic wheeze and shortness of breath with a prebronchodilator FEV1 ≥70% of predicted at screening. 6. Asthma symptoms treated (if necessary) only with intermittent short-acting ß-agonist therapy by inhalation. 7. Demonstration of a positive wheal reaction on skin prick testing to at least 1 common aeroallergen at screening. 8. Screening inhalational allergen challenge response demonstrating that the subject experiences both an early asthmatic response (EAR) and a late asthmatic response (LAR). 9. Methacholine PC20 ≤16 mg/mL at screening. 10. No history of smoking within 6 months of screening, and with a total pack year history of ≤10 pack years. 11. 12-lead ECG recording without signs of clinically relevant pathology or showing no clinically relevant deviations as judged by the investigator. 12. All values for hematology, clinical chemistry, and urinalysis within the normal range, or if abnormal, are deemed not clinically significant by the investigator with documented agreement from the medical monitor. 13. Is able to give written informed consent  Past or present disease which, as judged by the investigator, may affect the outcome of this study. 2. Respiratory tract infection and/or exacerbation of asthma within 4 weeks prior to the screening period. 3. Symptomatic allergic rhinitis. Those subjects with a history of allergic rhinitis may participate if asymptomatic at screening (and continue to be so at baseline on Day 1 prior to dosing) and if, in the opinion of the investigator, it is unlikely that disease exacerbation will occur during the course of the study. 4. History of life-threatening asthma. 5. Abnormal chest X-ray. 6. Use of oral, injectable, or dermal steroids within 3 months and/or inhaled steroids within 1 month of screening. 7. Use of cromoglycate, nedocromil, leukotriene receptor antagonists (zafirlukast, pranlukast, montelukast), and inhibitors of 5-lipoxygenase (zileuton) within 4 weeks of screening. 8. Use of immunosuppressives, anticoagulants (warfarin or heparin), or any medications that may interact with pharmacodynamic (PD) effects of AXP1275 within 4 weeks of screening. 9. Use of theophylline-containing agents (any type) and long-acting β2-agonists (salmeterol, formoterol) within 4 weeks of screening. 10. Positive screen for drug(s) of abuse (opiates, methadone, cocaine, amphetamines, cannabinoids, barbiturates, or benzodiazepines) or cotinine. 11. Positive for hepatitis B surface antigen, hepatitis C virus, or human immunodeficiency virus (HIV) 1/2. 12. Has participated in a clinical trial and has received an investigational product within 30 days prior to screening, or 5 elimination half lives of the investigational product, whichever is longer. 13. Has had significant blood loss (>500 mL) or donation of blood within 2 months prior to screening visit 1. 14. History of being unable to tolerate or complete methacholine or allergen challenge tests. 15. Subject is undergoing allergen desensitization therapy. 16. History of immunotherapy in the 3 years prior to screening or concurrently undergoing immunotherapy treatment. 17. Professional or ancillary personnel involved in the study. 18. Is not, in the opinion of the investigator, suitable for entry into the study