Patient description: A 42-year-old healthy woman came to the clinic to have her flu shot in early October. She works in a rehab center and has no underlying disease. It's her first time getting the vaccine this year. She is married for 5 years and uses barrier methods of contraception. Her menstrual cycle is irregular. She does not smoke. She is not on any medications. She exercises regularly for 30 minutes a day at least 5 days a week. She has no history of allergies to any food or drugs. Her past surgical history is significant for tonsillectomy and she is otherwise healthy.

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Covid19 Availability of a signed and dated informed consent of the volunteer to participate in a clinical trial, prior to any of the study procedures. 2. Verified diagnosis is "healthy" according to the data of the standard clinical, laboratory and instrumental examination methods. 3. Age from 18 to 60 years old inclusive. 4. Body mass index from 18.5 to 30 kg / m3. 5. Ability to attend all scheduled visits and all planned procedures and examinations. 6. Consent of volunteers to use effective contraceptive methods throughout the study, including the observation period for possible post-vaccination reactions  Contacts with COVID-19 patients for 14 days prior to the start of the clinical trial. 2. Hypersensitivity to any component of the product, allergy to the components of the vaccine. 3. The history of allergic reactions to any vaccination in the past. 4. Serious post-vaccination reactions/complications associated with any vaccination in the past. 5. Pregnancy and breastfeeding. 6. Military personnel on conscription. 7. Persons detained in pre-trial detention facilities and those serving sentences in prison. 8. Children under the age of 18. 9. Symptoms of any disease at the time of in the study or if it has passed less than 4 weeks since recovery. 10. The history of any acute respiratory disease within less than 3 months prior to in the study. 11. The history of acute infectious or non-communicable diseases, exacerbation of chronic diseases within less than 4 weeks before the start of the study. 12. The history of tuberculosis (pulmonary and extrapulmonary), cancer, autoimmune diseases, skin diseases (pemphigus, psoriasis, eczema, atopic dermatitis). 13. Long-term use (more than 14 days) of immunosuppressive drug, systemic glucocorticosteroids or immunomodulatory drugs within 6 months prior to the study. 14. Vaccination with any vaccine within one month prior to vaccination. 15. Taking immunoglobulin drugs or blood products within last 3 months prior to the study. 16. The history of treatment with human immunoglobulin drugs within, less than 6 months since such treatment. 17. Donation (450 ml of blood or plasma and more) within less than 2 months prior to the study. 18. Acute or chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, surgery on the gastrointestinal tract (except appendectomy). 19. The history of participation in other clinical trials within less than 3 months prior to the start of this study. 20. Individuals with alcohol, drug dependence or drug addiction. Taking more than 10 units of alcohol per week (1 unit of alcohol is equivalent to 1/2 litre of beer, 200 ml of wine or 50 ml of alcohol) or anamnestic information about alcoholism, drug addiction, and substance misuse. Individuals with positive results of urine examination for drugs and/or with alcohol findings in the exhaled air during the visits. 21. Mental illness and neurasthenia. 22. Non-compliance with the criteria. 23. Women in the premenopausal period (the last menstruation ≤ 1 year prior to the signing of informed consent) who are not surgically sterile and women who have reproductive potential, but do not use acceptable birth controls or do not plan to use them throughout the study and do not agree to a urine test for pregnancy during the participation in the study. 24. Positive test for HIV, viral hepatitis B and C, lues venerea. 25. Other comorbidities that the researcher believes may interfere with the evaluation of the study's objectives. And: 1. The researcher's decision to the volunteer for the benefit of the volunteer. 2. False (violation of and non-inclusion criteria) or the appearance of non-inclusion during the study. 3. The decision of the researcher or the Customer to the volunteer from the study due to a clinically significant deviation from the protocol/violation of the protocol. 4. Any undesirable phenomenon requiring the appointment of drugs not authorized by the protocol of this study. 5. Refusal of a volunteer to continue to participate in the study or his/her indiscipline. 6. Volunteer's desire to complete the study early for any reason. 7. Volunteer's failure to show up for a scheduled visit without the researcher's warning or loss of communication with the volunteer