Patient description: Patient A is a 30-year-old male who was admitted to the hospital after 10 days of cough, profuse nocturnal sweating and loss of appetite. He had traveled to India 1 months ago and has not any positive history of TB vaccination. He is a previously healthy man, working as an engineer in a high tech company. He doesn't smoke o use any illicit drugs. He was febrile (38 c) with heart rate of 115 b/min, respiratory rate of 22, BP of 125/75 mmHg and O2 sat of 97%. Chest X-ray showed infiltrate in the middle of left lung with diameter of 1.8 cm with signs of cavitation. The sputum smear revealed positive sputum culture for Mycobacterium tuberculosis which are sensitive of the first-line TB drugs (isoniazid, streptomycin, rifampicin and ethambutol). Lab study is reported bellow: Hgb: 13 g/dl WBC: 14000 /mm3 Plt: 300000 /ml AST: 13 U/L ALT: 15 U/L Alk P: 53 U/L Bill total: 0.6 mg/dl Na: 137 mEq/l K: 4 mEq/l Creatinine: 0.5 mg/dl BUN: 10 mg/dl ESR: 120 mm/hr

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Mycobacterium Avium-Intracellulare Infection Patients may be enrolled in the study whether or not they are on antimycobacterial treatment for MAC at the time of screening, provided they have bacteriological evidence of active pulmonary MAC infection at screening and provided they meet the following Men or women enrolled in the study must be 18 years of age or older. Patients must have a documented diagnosis of pulmonary MAC disease made in accordance with the ATS for Diagnosis of Pulmonary MAC Infection. Patients must have abnormal HRCT findings at the time of screening consistent with pulmonary MAC infection. Patients with pulmonary MAC disease in whom MAC has been grown only from bronchoalveolar lavage, should undergo sputum induction at Screening and must have a positive Screening AFB smear or a positive Screening culture for MAC. Patients previously treated for at least 6 months but not currently on therapy for pulmonary MAC disease may enroll regardless of severity of disease if they meet the following Patients must have been received at least 6 months of therapy with at least two drugs; Patients must have persistence or recurrence of radiographic abnormalities consistent with pulmonary MAC disease; Patients must have a positive sputum AFB smear at Screening (subsequently confirmed by a positive Screening culture for MAC) OR: A sputum culture at screening positive for MAC OR: After at least 6 months of antimycobacterial therapy, a sputum culture, positive for MAC within 24 weeks prior to, or at the time of screening. Patients receiving antimycobacterial therapy for MAC at the time of screening: Must have completed at least 6 months of treatment with at least two drugs; Must have a sputum culture positive for MAC within 12 weeks prior to study entry and a positive sputum AFB smear at the time of screening (subsequently confirmed by a positive Screening culture for MAC). OR: A sputum culture at Screening positive for MAC OR: Where semi-quantitative culture results are available, at least 1 sputum culture 1 or greater positive for MAC (i.e. greater or equal to 50-100 colonies on solid media) with the previous 12 weeks, persistent or worsening symptoms consistent with MAC pulmonary disease and persistent or worsening radiographic abnormalities. Patients who have never been previously treated for pulmonary MAC or who have received less than 6 months of treatment must have: evidence of moderate or severe pulmonary MAC involvement defined by the presence of one or more of the following on HRCT at screening: cavitary disease; bronchiectasis with either multilobar or upper lobe infiltrates, or nodular disease; AND In addition to cough, at least two of the following symptoms suggestive of clinically significant MAC pulmonary disease: hemoptysis, dyspnea, fatigue, malaise, weight loss, night sweats; AND Positive sputum AFB smear at Screening (subsequently confirmed by a positive Screening culture for MAC) or a sputum culture positive for MAC within 24 weeks prior to or at the time of screening. Patients must not have a history of HIV infection or a positive HIV antibody test by Western Blot. Patients must not have a disseminated or extra-pulmonary MAC infection. Patients must not have had more than one sputum culture positive for nontuberculous mycobacteria other than MAC within the previous 6 months thought by the Principal Investigator to be causing or contributing to the patient's pulmonary infection. Patients must not have pre-treatment MAC isolate resistant to macrolide defined by a MIC greater than 8.0 microgram/mL. Patients must not have active lung cancer, ongoing or previous treatment for lung cancer within the past 2 years, or a lesion suspicious for lung cancer at Screening. Patients successfully treated for lung cancer more than two years prior to Screening, and who have no evidence of recurrence are eligible for enrollment. Patients must not have an active disease known to cause immunosuppression including hematological malignancy or autoimmune disorder. Patients must not have undergone therapy with chronic oral corticosteroids, cyclophilin binding agents (e.g. cyclosporin), immunosuppressives (e.g. azathioprine), chemotherapeutic agent(s) (such as cyclophosphamide, methotrexate, or cancer chemotherapy) or radiations. Patients must not have undergone investigational therapy for any indication within 28 days prior to treatment. Patients must not have a history of intolerance to both azithromycin and clarithromycin. Patients must not have a history of intolerance to rifampin or ethambutol. Patients must not have undergone treatment with IFN-gamma 1b for nontuberculous mycobacteria for greater than or equal to 4 weeks within the past 2 years. Patient must not have a known intolerance or allergic reaction to IFN-gamma 1b. In patients who have not been previously treated for pulmonary MAC, there must be an absence of parenchymal involvement, cavitary disease or upper lobe nodular disease on HRCT. Patients must not have a confirmed diagnosis of cystic fibrosis. Patients must not have active sarcoidosis. Patients must not have an underlying lung condition necessitating chronic use of more than 5 L of supplemental oxygen in order to maintain an oxygen saturation of greater than or equal to 88%. Patients must not have liver function at Screening above specified limits: total bilirubin greater than or equal to 1.5 x the upper limit of normal (ULN), AST (SGOT), ALT (SGPT) or alkaline phosphatase greater than or equal to twice the ULN. In patients with abnormalities in their liver enzymes felt to be related to alcohol, liver enzymes should be repeated after the patient has abstained from drinking alcohol for 2 weeks. If the values are still abnormal, the patient will be excluded from the study. Patients must not have significant chronic liver disease (e.g. cirrhosis). Patients must not have a hematology at Screening outside of specified limits: total white blood cell count less than or equal to 2,500 cells/mm(3), hematocrit less than 30% or greater than 59%, platelets less than 100,000 cells/mm(3). Patients must not have a serum creatinine greater than 1.5 x ULN. No pregnant or lactating women. No women of childbearing potential who are unwilling to practice abstinence or prevent pregnancy by at least a barrier method of birth control. Women of childbearing age are required to have a negative serum or urine pregnancy test at Screening and Baseline. No one with the inability to give informed consent. Patients must not have Karnofsky performance score less than 60. Patients must not have any condition other than pulmonary MAC disease which, in the opinion of the site Principal Investigator, is likely to result in the death of the patient within the next year. Patients must have no history of unstable or deteriorating cardiac or neurological disease including but not limited to: Myocardial infarction or coronary bypass surgery or angioplasty within the past 6 months; Congestive heart failure requiring hospitalization within the past 6 months; Uncontrolled arrhythmias; CVA or TIA's within the past 6 months. Patients must not have any cardiac or neurological conditions, which, in the opinion of the site Principal Investigator, might be significantly exacerbated by any flu-like syndrome associated with the administration of IFN-gamma 1b. Patients must not have a history of deep venous thrombosis or pulmonary embolism within the past 6 months. Patients must not have a history of CNS disorder, which, in the opinion of the site Principal Investigator, might be exacerbated by any flu-like syndrome, associated with the administration of IFN-gamma 1b. No patients with a history of multiple sclerosis. No patients with a history of seizures within the past 10 years or taking seizure medication. No patients with a history of severe or poorly controlled diabetes mellitus. No patients who in the opinion of the Investigator are not suitable candidates for enrollment or would not comply with the requirements of the trial. Patients must not have the presence of other chronic disease, which, in the opinion of the investigator would adversely affect a patient's ability to participate or complete participation in the study. Patients must not have Screening laboratory values of Grade 3 or 4 toxicity according to the Modified WHO Common Toxicity Criteria. Subjects who fail screening on the basis of abnormal laboratory values may undergo a repeat evaluation at the Investigator's discretion