Patient description: The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Painful Intermetatarsal Neuroma (Morton's Neuroma) Male or female aged >18 years at the time of the Screening Visit. 2. Pain associated with intermetatarsal neuroma (Morton's neuroma) for a minimum of 3 months prior to Screening. 3. Diagnosis of Morton's neuroma, confirmed by evidence of focal tenderness and pain in the distal third intermetatarsal space, AND either Presence of neuroma on ultrasound, or Elicitation of Mulder's sign or a positive Gauthier's test. 4. A mean neuroma foot pain score of 4 or greater during the 7 days prior to dosing (NPRS, 0-10) as rated daily at bedtime (9:00 PM ± 3 hours) for average pain with walking in the last 24-hours. At least 5 of 7 scores during the week prior to dosing must be recorded. 5. Tried conservative treatment with analgesics (acetaminophen or nonsteroidal anti-inflammatory drugs) and non-pharmacologic therapy (such as wide shoes, orthotics, and/or arch supports) without complete success. 6. Female not of childbearing potential, defined as post-menopausal for at least 1 year, or surgically sterile (bilateral tubal ligation, bilateral oophorectomy, or hysterectomy), or practicing one of the following medically acceptable methods of birth control throughout the study period Hormonal methods such as oral, implantable, injectable, or transdermal contraceptives for a minimum of 1 full cycle (based on the subject's usual menstrual cycle period) before investigational product (IP) administration Total abstinence from sexual intercourse since the last menses before IP administration Intrauterine device Double barrier method (condoms, sponge, diaphragm, with spermicidal jellies or cream). 7. Willing and able to understand the study requirements, abide by the study restrictions, complete the study procedures, pain scales, and daily IWRS/IVRS entries, and to communicate meaningfully with the study personnel. 8. Signed an Informed Consent Form approved by the Institutional Review Board. 9. Subject agrees to take only the rescue medications for neuroma foot pain from the time of screening through study completion, and agrees to discontinue all topical medications for neuroma pain after Screening  Clinically significant bursitis in either foot. 2. The subject has more than one painful intermetatarsal neuroma in the affected foot which, in the opinion of the Investigator, would interfere with evaluation of the symptoms and functional limitations that arise from the intermetatarsal neuroma in the affected foot. 3. Radiography within 6 months of the Treatment Visit (Day 1) to musculoskeletal pathology must be performed, to any osseous abnormality such as stress fracture, osteophyte, tumor, or cyst in the bones or toes adjacent to the third inter-metatarsal space or any significant evidence of arthritis in the joints of the 3rd and 4th metatarsal-phalangeal joints or inter-phalangeal joints of the 3rd and 4th toes. 4. Previous neurectomy in the same nerve. 5. Any painful condition or prior surgery on the affected ankle or foot, which, in the judgment of the investigator, might adversely impact the interpretation of study data. 6. Other painful foot pathology (e.g., bunion, hammertoe, plantar fasciitis etc.) or evidence of clinically meaningful ischemia which, in the judgment of the investigator and the medical monitor, would interfere with evaluation of the symptoms and functional limitations that arise from the intermetatarsal neuroma. 7. Other chronic pain anywhere in the body that is greater than or equal to the intensity of foot pain from intermetatarsal neuroma. 8. Signs of arterial insufficiency in the feet, including clinically meaningful edema. 9. Current use of opioids for any condition. 10. Corticosteroid injection in the affected foot within 30 days of Screening. 11. History of clearly documented allergic reaction to local anesthetics or capsaicin. 12. Prior use of injection with a sclerosing agent, such as alcohol or phenol, in the affected foot for Morton's neuroma. 13. Presence of any medical condition or unstable health status that, in the judgment of the investigator, might adversely impact the conduct of the study or resulting data, including chronic conditions that are likely to alter the rate of healing or are likely to result in safety complications unrelated to the study medication, such as uncontrolled diabetes mellitus or vascular disease. 14. Regular use of anticoagulant blood thinners (except low-dose aspirin or Plavix which are allowed). 15. Active cutaneous disease at the anticipated site of study drug injection that would prevent the safe administration of study drug. 16. Ulcer or open wound anywhere on the affected foot. 17. Clinically significant abnormal laboratory result at the Screening Visit (in the opinion of the investigator). 18. Has diabetic neuropathy or other peripheral neuropathy in the affected foot. 19. Use of an investigational medication in the 30 days prior to the current study or scheduled to receive such an agent while participating in the current study. 20. Prior participation in an ALGRX-4975 or CNTX-4975 study. 21. Has a history of substance use disorder within the previous year as defined by the Diagnostic and Statistical Manual for Mental Health Disorders, fifth edition, has current evidence for a substance use disorder, is receiving medicinal treatment for drug abuse, or tests positive upon urine drug screen for a substance of abuse. 22. Has a positive pregnancy test at the Screening or Treatment Visit. 23. Has any condition or is taking any medication that would be contraindicated for study participation