Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Onychomycosis A witnessed, signed informed consent approved by Institutional Review Board Male or female of any race at least 18 years of age but not older than 65 years of age at the time of screening Body Mass Index between 18.5 and 35, inclusive Onychomycosis involving > 80% of both great toenails, as determined by visual inspection after the nail has been trimmed Each great toenail possess a combined thickness of the nail plate and nail bed > 3 mm At least six additional toenails with clinical diagnosis of onychomycosis A positive KOH wet mount for at least one great toenail If subject is a female of childbearing potential, must be using a highly effective method of birth control (e.g. implants, injectables, combined oral contraceptives, some intrauterine contraceptive devices) during the study Considered reliable and capable of understanding his/her responsibility and role in the study  History of allergy to any of the test product(s) or any components in the test product(s) or history of hypersensitivity or allergic reactions to any of the study preparations as described in the Investigator's Brochure Clinically significant laboratory abnormalities that would interfere with the conduct or interpretation of the study or jeopardize his/her safety Diabetes mellitus requiring treatment other than diet and exercise Unwilling to refrain from the use of nail cosmetics such as clear and or colored nail lacquers from the screening visit until the end of the study Nursing, pregnant or planning to become pregnant during the study Has not undergone the specified washout period(s) for the following topical preparations or does the subject require the concurrent use of any of the following topical medications: 1. Topical antifungal applied to the feet (does not antifungals for treatment of T. pedis during the study: 4 weeks 2. Anti-inflammatories, corticosteroids, topical immunomodulators: 2 weeks Has not undergone the specified washout period(s) for the following systemic medications or does the subject require the concurrent use of any of the following systemic medications: 1. Corticosteroids (including intramuscular injections): 2 weeks 2. Antifungals for treatment of onychomycosis or any systemic antifungal with known activity against dermatophyte: 24 weeks 3. Systemic immunomodulators: 4 weeks Received treatment of any type for cancer within the last 6 months History of any significant internal disease Nail or anatomic abnormalities of the toe, e.g., genetic nail disorders, primentary disorders, onychogryphosis, trauma to the nail(s) to be treated