Patient description: The patient is a 60 year old man complaining of frequent headaches, generalized bone pain and difficulty chewing that started 6 years ago and is worsening. Examination shows bilateral swellings around the molars. The swellings have increased since his last examination. Several extraoral lesions are detected in the head and face. The swellings are non-tender and attached to the underlying bone. Further evaluation shows increased uptake of radioactive substance as well as an increase in urinary pyridinoline. His serum alkaline phosphatase is 300 IU/L (the normal range is 44- 147 IU/L). His family history is only significant for hypertension in his mother and DM type 2 in his father. The diagnosis of Paget's Disease of Bone was confirmed and Bisphosphonate will be started as first-line therapy.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Tension-Type Headache Patient must be between 18 and 65 years old and report ALL YES under one of the Tension-type Headaches described below: 2.2 Frequent Episodic Tension-type Headaches: Frequent episodes of headache, typically bilateral, pressing or tightening in quality and of mild to moderate intensity, lasting minutes to days. The pain does not worsen with routine physical activity and is not associated with nausea, but photophobia or phonophobia may be present. 1. At least 10 episodes of headache occurring on 1 days per month on average for >3 months (12 and <180 days per year) 2. Headache lasting from 30 minutes to 7 days 3. Patient has headaches that have at least two of the following four characteristics: 1. Bilateral location 2. Pressing or tightening (non-pulsating) quality 3. Mild or moderate intensity 4. Not aggravated by routine physical activity such as walking or climbing stairs 4. Both of the following are true: 1. No nausea or vomiting 2. No more than one of photophobia or phonophobia 2.2.1 Frequent Episodic Tension-type Headache associated with pericranial tenderness 1. Episodes fulfilling for Frequent episodic tension-type headache (See 2.2 above) 2. Increased pericranial tenderness on manual palpation. 2.3 Chronic Tension-type Headaches: A disorder evolving from frequent episodic tension-type headache, with daily or very frequent episodes of headache, typically bilateral, pressing or tightening in quality and of mild to moderate intensity, lasting hours to days, or unremitting. The pain does not worsen with routine physical activity, but may be associated with mild nausea, photophobia or phonophobia. 1. Headache occurring on 15 days per month on average for >3 months (180 days per year) 2. Headache lasting hours to days, or unremitting 3. At least two of the following four characteristics 1. Bilateral location 2. Pressing or tightening (non-pulsating) quality 3. Mild or moderate intensity 4. Not aggravated by routine physical activity such as walking of climbing stairs 4. Both of the following: 1. No more than one of the photophobia, phonophonbia, or mild nausea 2. Neither moderate or severe nausea nor vomiting 2.3.1 Chronic Tension-type Headache associated with pericranial tenderness 1. Headache fulfilling for 2.3 Chronic tension type headache 2. Increased pericranial tenderness on manual palpation  Must all be NO to be eligible 1. Patient presents with other primary and/or secondary headache 2. Patient presents with Medication Overuse Headache defined as: 1. Headache occurring on 15 days per month in a patient with a pre-existing headache disorder 2. Regular overuse for >3 months of one of more drug that can be taken for acute and/or symptomatic treatment of headache 3. Not better accounted for by another headache diagnosis 3. History of head/neck trauma (to whiplash) 4. History of Cervical Stenosis 5. Presence of any of the following atherosclerotic risk factors: hypertension, diabetes, heart disease, stroke, transient ischemic attack, peripheral vascular disease, smoking, hypercholesterolemia or hyperlipidemia 6. Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumors, fracture, metabolic diseases, RA, osteoporosis, history of prolonged steroid use, etc. 7. Bilateral upper extremity symptoms 8. Evidence of CNS involvement, to hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, presence of pathological reflexes (i.e. positive Hoffman's and/or Babinski reflexes). 9. Two or more positive neurologic signs consistent with nerve root compression, including any 2 of the following: 1. Muscle weakness involving a major muscle group of the upper extremity. 2. Diminished UE deep tendon reflex of the biceps, brachioradialis, triceps or superficial flexors 3. Diminished or absent sensation to pinprick in any UE dermatome. 10. Prior surgery to neck of thoracic spine 11. Involvement in litigation or worker's compensation regarding their neck pain and/or headaches 12. Diagnosis of fibromyalgia syndrome 13. Received anesthetic blocks or botulinum toxin within the previous 6 months 14. Received physical treatment in the neck and head the previous 6 months 15. Any condition that might contraindicate spinal manipulative therapy 16. Pregnancy