Patient description: The patient is a 15 year old girl with the history of recurrent bilateral headache. The attacks come 2 times or more per week and each episode lasts around a day or a half. The pain is pulsating in quality and severe in intensity, causing trouble in her routine physical activity. The attacks are associated with nausea and photophobia. She recently noticed that that there are more attacks around her menstrual period. She is diagnosed with the migraine headache and is under treatment. She is a high-school student and living with her both parents. She is a book worm and spend her free time in a public library near her home. She is also interested in writing stories and has several short stories in English. She rarely does exercise. Her BMI is 21 with the BP of 100/60. There is nothing remarkable in her physical exam.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Migraine With Aura Male or female migraineurs with aura between 18 and 65 years old, inclusive 2. Meets the following for migraine headache with aura Diagnosed with a history of migraine with aura Aura consisting of at least one of the following, but no muscle weakness or paralysis Fully reversible visual symptoms (e.g. flickering lights, spots, lines, loss of vision) Fully reversible sensory symptoms (e.g. pins and needles, numbness) Fully reversible dysphasia (speech disturbance) Aura has at least two of the following characteristics Visual symptoms affecting just one side of the field of vision and/or sensory symptoms affecting just one side of the body At least one aura symptom develops gradually over more than 5 minutes and/or different aura symptoms occur one after the other over more than 5 minutes Each symptom lasts from 5-60 minutes 3. At least one migraine headache with aura every 8-weeks and resulting in moderate to severe pain (on a 4-point categorical scale) within 2 hours of the onset of aura. 4. Migraine pain following aura in at least 75% of occurrences 5. The subject has a body mass index (BMI) within the range of 18 to 32 6. The subject is in general good health as determined by the medical history, physical exam, clinical laboratory tests, vital signs [heart rate (HR) and blood pressure (BP; after a 3-minute sitting period)] and ECG • ALT cannot be above 1.5x upper limit of normal; creatinine and urea must be within normal limits 7. The subject must be able to speak, read, and understand Danish sufficiently to understand the nature of the study, to provide written informed consent, and complete all study assessments 8. The subject is willing and able to comply with all testing requirements defined in the protocol 9. All females will avoid pregnancy at least 10 days before Visit 1, during the study and up until 3 months after Visit 2 10. Women of childbearing potential must be using a reliable form of contraception. A reliable form of contraception is defined as follows  Presence of any clinically significant condition that would preclude study participation, as evaluated by the investigator 2. Are pregnant or lactating 3. History of significant neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, rheumatologic, autoimmune, or metabolic disease 4. Receiving any medication that, in the opinion of the Investigator or designee, may pose a risk of compromising tolerance or compliance 5. Are known to or suspected to be currently abusing alcohol or drugs, or have a history (within the past 12 months) of active alcohol or drug abuse 6. Participation in another drug or biologic study within 30 days preceding randomization into this study or during participation in this study 7. Subjects who are unable or unwilling, in the opinion of the Investigator, to comply with all study procedures and cooperate fully with study center staff