Patient description: The patient is a 25-year-old man with type 1 diabetes confirmed with molecular analysis 7 years ago. He presents to the clinic with shortness of breath and fatigue during activities. He claims mild dyspnea after climbing 3 floors, no dyspnea at rest and no angina (New York Heart Association class 2). He is diagnosed with cardiomyopathy that will be treated with ACE inhibitors and Beta blockers. His takes 70/30 Insulin and vitamin D supplements. His past medical history is not significant for any other medical issues. His family history is positive for DM type 1 in his uncle and his grandfather. His lab study is as bellow: FBS: 100 mg/dl HbA1c: 6.5% Cholesterol: 190 mg/dl TG: 140 mg/dl LDL: 125 mg/dl HDL: 40 mg/dl

Clinical trial eligibility criteria: eligible ages (years): 16.0-999.0,  Type 1 Diabetes Mellitus Key 1. Diagnosis of type 1 diabetes, within 12 months of first dosing, confirmed by positive lab result for one or more of the following types of autoantibodies: 1. Glutamic acid decarboxylase (GAD65) 2. Insulinoma associated protein 2 (IA-2, also known as ICA-512) 3. Zinc transporter 8 (ZnT8). 2. Age 16 or older and able to provide informed consent/assent. 3. If a participant is female with reproductive potential, willing to avoid pregnancy through the duration of the trial. 4. Signed and dated written informed consent/assent. Key  Poorly controlled diabetes despite insulin therapy, who in the opinion of the investigator would not be a good candidate for participation in a clinical trial 2. Screening hemoglobin <10.0 g/dL; leukocytes <3,000/uL; neutrophils <1,500/uL; lymphocytes <800/uL; platelets <100,000/uL 3. Screening Urine Albumin Excretion > 300mg/gmCr 4. Screening eGFR < 60 mL/min/1.73m2 5. Screening ALT or AST > 1.5x upper limit of normal (ULN) 6. Screening bilirubin > 2.0 mg / dL, or > 3.0 mg / dL for participants with Gilbert's Syndrome 7. Current use of immunosuppressive or immunomodulatory therapies, including pharmacologic doses of systemic steroids. However, topical steroidal creams and inhaled steroids without large systemic absorption are allowed. 8. Coincident medical condition likely to require immunosuppressive or immunomodulatory therapies. 9. Coincident medical condition likely to limit short term (5 year) life expectancy (malignancy, symptomatic coronary artery disease, recent stroke) 10. Prior radiation therapy, immunotherapy (within 1 year of screening), or chemotherapy 11. Serologic evidence of current HIV-1 or HIV-2 infection 12. Serologic evidence of hepatitis C infection 13. Serologic evidence of acute or chronic active hepatitis B as measured by Core Ab positive and / or Surface Antibody antigen positive 14. Subjects with other autoimmune conditions (except compensated or treated autoimmune thyroid, celiac, alopecia, or vitiligo diseases) 15. Women who are pregnant (pregnancy testing during screening), breastfeeding, or planning pregnancy during the study period 16. Inadequate venous access to support leukapheresis 17. Any condition that in the opinion of the investigator(s) would preclude the subject from participating in a clinical trial. 18. Abnormal screening ECG that in the opinion of the investigator or sponsor would pose a safety risk