semaj83/ctmatch_classification huggingface dataset:
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Renal Function Impairment in Healthy Volunteers Informed consent in writing available. 2. Willing and able to comply with all requirements of the study. 3. Male, 18 and 45 years (inclusive). 4. Subject has a body weight between 60 kg and 100 kg, extremes included. 5. BMI 18 to 27 kg/m2. 6. Non-smoker 7. Serum creatinine within reference range (≤1.2 mg/dL) and Cockroft-Gault Clearance > 90 ml/min 8. Good general health as judged by the Investigator, as determined by medical history, physical examination, vital signs (systolic and diastolic blood pressure and pulse rate) and clinical laboratory parameters (clinical chemistry, hematology, and urinalysis)  Clinically significant abnormalities in physical examination, vital signs or clinical laboratory parameters (according to the Investigator's judgment). 2. Serum glutamate oxaloacetate transaminase or glutamate-pyruvate transaminase > 2-times above the upper limit of normal range. 3. Subject with Cockcroft-Gault clearance < 90 ml/min. 4. Clinically significant history of cardiovascular disease or any known present cardiovascular disease. 5. History of clinically significant neurological, gastrointestinal, renal, hepatic, psychological, pulmonary, metabolic, endocrine, hematological, or other major disorders. 6. Office blood pressure at screening higher than 160/100 mmHg, or lower than 95/55 mmHg. 7. Office heart rate at screening after at least 5 minutes outside the range of 50 beats per minute (inclusive). 8. Concomitant use of OTC medication within 1 week prior to dosing, except use of paracetamol (up to 2 g/day). 9. Participation in any other clinical study within 30 days prior to in this -
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-99.0,  Parkinson Disease Dystonia Essential Tremor FOR Patients diagnosed with a tremor syndrome, including, but not limited to Essential tremor (per definition of the Tremor Research Group) Parkinson disease (per UK Brain Bank criteria) Focal tremor such as isolated head tremor, voice tremor Task-specific tremor such as primary writing tremor Orthostatic tremor Patients with other tremor syndromes such as dystonic tremor, intention tremor, etc Age 18 or older Able to give informed consent  FOR Problematic alcohol use, as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT) History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures History of psychotic disorder, Bipolar Disorder or a current depressive episode History or clinical evidence of another neurologic disorder than a tremor syndrome as defined above, which may interfere with the ability to comply with protocol requirements or interpret the obtained results FOR Have abnormal findings of clinical significance on the neurological examination that may affect the scientific integrity of the study Problematic alcohol use, as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT) History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures History of psychotic disorder, Bipolar Disorder or a current depressive episode
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Essential Tremor Cervical Dystonia Focal Dystonia Tremor Subjects Must be 18 years or older Fulfill the diagnostic of essential tremor, pure dystonic tremor and tremor associated dystonia, as defined by the Consensus Statement of the Movement Disorder Society on Tremor, 1998. We will recruit patients displaying hand tremors in each group as the follows Hand tremor patients in ET group Dystonic hand tremor patients in pDT group Cervical dystonia (CD) patients or spasmodic dysphonia and hand tremor without clinical evidence of hand dystonia in TAWD group Ability to give informed consent Ability to comply with all study procedures, based on the judgment by the investigator(s) Agree to not drink caffeine or alcohol for 48 hours before participating in the protocol. Healthy Volunteers Must be 18 years or older  Patients Botulinum toxin treatment < 3 months prior to visit Employees and/or staff of NINDS Has used illegal drugs within the past 6 months based on history. The intent is to those with drug use that may affect study results. Participants who appear to be intoxicated at the time of testing will be rescheduled Has more than 7 alcoholic drinks a week in the case of a woman and 14 alcoholic drinks a week in the case of a man Abnormal findings on neurologic exam (other than tremor and dystonia in patient group) Has had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures Has major depression or any major mental disorders (axis I disorders) Has a neurologic disorder other than tremor or dystonia Has had a head injury where there was a loss of consciousness for more than a few seconds
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 21.0-90.0,  Essential Tremor Provide informed consent Patient is over 21 years of age Patient has had a significant disabling, medication-refractory upper extremity tremor with no evidence of non-ET central nervous system disease or injury for at least three (3) months prior to implantation of Activa SC, PC, or RC device Patient receives Vim electrode and Activa SC, PC or RC device implants, and recovers fully after surgery Patient is available for study participation after their clinical programming appointments for six months  Medication related movement disorders Any suspicion of Parkinsonian tremor, including presence of Parkinsonian features such as bradykinesia, rigidity, or postural instability Severe medical co-morbidity including cardiovascular disorder, lung disorder, kidney disease, continuous neurological disease, hematological disease, or frailty that impact tolerability of the surgery as judged by the screening physicians Patient is undergoing a lead revision surgery
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Coronary Artery Disease Clopidogrel, Poor Metabolism of Patients with oral clopidogrel treatment admitted to hospital within 24 hours or long-term follow-up outpatients with oral clopidogrel treatment; 2. The platelet aggregation rate (PAgR) measured with light transmission aggregometry (LTA) is decreased no more than 10% from baseline level, or PAgR is more than 46% and the percentage of inhibition of ADP-induced platelet aggregation measured by thrombelastogram is not more than 30%  Planned use of glycoprotein IIb/IIIa receptor inhibitors, adenosine diphosphate (ADP) receptor antagonists, or anticoagulant therapy during the study period; 2. Platelet count <100g/L; 3. Creatinine clearance rate < 30ml/min; 4. Diagnosed as respiratory or circulatory instability (cardiac shock, severe congestive heart failure NYHA II-IV or left ventricular ejection fraction < 40%); 5. A history of bleeding tendency; 6. Aspirin, ticagrelor or clopidogrel allergies; 7. Severe liver injury
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease for PD group Age > 18 year-old Diagnosis of PD with onset <2 years from enrollment Available DAT SPECT performed in Geneva University Hospitals <6 months before for control group: Age and sex-matched control patients Age > 18 year-old No known neurological condition interfering with motor and cognitive abilities No medication interfering with central nervous system (including antidepressants, antipsychotics, hypnotics)  for both groups Major depressive state (Hospital Anxiety and Depression scale ≥11 for depression score) Cognitive decline (Mini-Mental Score ≤ 22/30) Debilitating tremor (Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III rest, postural and action tremor ≥2/4) Significant akinesia (MDS-UPDRS III hand brady-akinesia score ≥2/4)
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Crohn Disease Ulcerative Colitis Intestinal Helminthiasis The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his in the study was that he was healthy
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Genetic/Metabolic Liver Diseases Patients who were diagnosed or possibly diagnosed with Wilson's disease, hereditary hemochromatosis, hereditary hyperbilirubinemias, inherited cholestatic liver disease or other genetic/metabolic liver diseases  Patients who are unable or unwilling to provide informed consent
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-40.0,  Penile Amputation Male patients 18 years or older with total or partial penile loss as a complication from ritual circumcision, who are willing and able to provide written, informed consent  Immunosuppression (HIV positive, diabetes mellitus or drugs affecting immune response) Active tuberculosis (TB) or a history of TB Previous forearm free flap Disorders of circulation (e.g. peripheral vascular disease, vasculitis) History of prior malignancy Renal failure and not on a renal replacement programme Systemic disease deemed by the investigator serious enough to preclude the use of immunosuppression agents Mental illness Patients who are unwilling, unable or unlikely to comply with immunosuppressive treatment and regular follow-up
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-80.0,  Action Tremor Min 5-yr duration chronic action tremor of upper limb(s), w/ or w/out tremor of head/neck, trunk, lower limbs, who have insufficient relief from adequate trials of recommended medications. The arm tremor must be so severe that it interferes with the patient's work performance or activities of daily living, such as drinking/eating, dressing/hygiene, and/or writing. Clinical diagnosis (according to defined by the Consensus Statement of the Movement Disorders Society) Essential Tremor, Dystonic Tremor, Cerebellar Tremor idiopathic or secondary (to e.g.MS or SCA), or severe PD tremor (who are not eligible for DBS of the subthalamic nucleus)  Brain MRI showing so marked general atrophy, or supra-tentorial white matter changes, that the safety of the procedure is affected. Co-morbidity of dementia or other severe neuropsychiatric disorder (major depression or anxiety disorder, active/recent psychosis, drug or other substance abuse). Increased risk of bleeding, cancer at advanced/not stabilized stage, other severe co-morbidity (e.g. With chronic pain, short life expectancy,). Other surgical contraindications
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Hepatitis C Age > 18 years, male or female 2. Willing and able to comply with program assessment, including routine tests, attendance for follow up and compliance with medicine taking. 3. Able to provide written agreement (or witnessed in the case of patients who cannot read and write) 4. Have a diagnosis of hepatitis C (based on a hepatitis C point-of-care test and then confirmed by PCR) with or without HIV Additional for PK sub-study 1. HIV well-controlled on current therapy (co-infected patients only) 2. Willing and able to comply with the additional blood sampling in the PK-PD sub-study protocol for the duration of the study  Current pregnancy (pregnancy test to be performed in women of child-bearing age) 2. Previous HCV therapy. 3. HCV PCR negative 4. Patients with significant renal impairment with Cr Cl < 50 ml/min. 5. Known hypersensitivity to any part of the drug regime. 6. Presence of significant comorbidity with life expectancy of less than 12 months. 7. Clinical evidence of decompensated cirrhosis with current or previous episode of ascites, variceal bleed, encephalopathy, and treated hepatocellular cancer (HCC) [Child-Pugh score B or C]. 8. Presence of concomitant medical or social situation that would make it difficult for the patient to comply with program protocol or put the patient at additional risk 9. Concomitant medications that cause unacceptable drug-drug interactions. Additional for PK sub-study 1. Anaemia (Hb <100 mg/L)
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Hypertension,Essential Obstructive Sleep Apnea Left Ventricular Hypertrophy confirmation of resistant hypertension(RAH). RAH was recognized when in spite of the use of at least 3 antihypertensive agents (including a diuretic) in maximum doses, it was impossible to achieve the target values of BP (< 140/90 mmHg) diagnosing of moderate or severe sleep apnea (OSA) on the basis of apnoea-hypopnea index (AHI) in polysomnography. AHI was defined by the total number of apnoea's and hypopneas per hour of sleep. The severity of OSA was determined as: mild (AHI 5-15), moderate (AHI 15 and severe (AHI ≥ 30) signing informed and written consent to participation in the study  secondary hypertension (other than primary hyperaldosteronism) myocardial infarction stroke within 6 months before the study congestive heart failure with New York Heart Association (NYHA) grade III-IV chronic kidney disease (GFR < 30 ml/min) active addiction to alcohol or psychoactive substances active cancer disease
Patient description: A 22-year-old Caucasian man came to the Clinic with a history of tremors since a year ago. The tremor was first in his right hand while holding something. Later the tremor became continuous and extended to both hands and legs and even at rest. The Kayser-Fleischer' ring was detected in the ophthalmologic exam. The physical exam revealed jaundice, hepatosplenomegaly and hypotonia of the upper limbs. He had a constant smile on his face, however, he has aggressive behavior according to his parents' explanation. His laboratory study was significant for a low serum caeruloplasmin (0.05 g/l), and a raised 24 hour urine copper excretion (120 μg/24 h). Wilson disease was confirmed by high liver copper concentration (305 μg/g dry weight of liver).

Clinical trial eligibility criteria: eligible ages (years): 0.0-999.0,  Cardiopulmonary Resuscitation Patients who died in 2013 or 2015 known to the individual hospice team (in-patient unit, day unit or community team) Completed form within the clinical notes which was completed in 2013 or 2015  No completed form within the clinical notes form not completed in 2013 or 2015