Patient description: The patient is a 57-year-old man with abdominal pain and vomiting. The pain started gradually about 20 hours ago in the epigastric and periumbilical regions, radiating to his back. He drinks around 60 units of alcohol per week and smokes 22 cigarettes per day. He is healthy with no history of allergies or using any medications. His family history is positive for type 2 diabetes (his father and sister). He lives alone and has no children. The abdomen is tender and soft. His bowel sounds are normal. His heart rate is 115/min and blood pressure 110/75 mmHg. The lab results are remarkable for leukocytosis (19.5), urea of 8.5, high CRP (145), high amylase (1200) and Glc level of 15. Cross-sectional imaging was negative for obstructive pancreatitis.

Clinical trial eligibility criteria: eligible ages (years): 20.0-40.0,  Bioequivalence Healthy Caucasian male subjects aged between 20 and 40 years, 2. Non smokers or smoking maximum 5 cigarettes a day, those who won't smoke or drink coffee during the study period, 3. Negative Covid-19 Rapid Test results and two Negative Covid-19 PCR test results, 4. Negative alcohol breath test results, 5. Normal physical examination at screening visit, 6. Having the Body Mass Index ranged between 18.5-30 kg/m2 (see Appendix I) which is in the desirable range according to the age, 7. Ability to communicate adequately with the investigator himself or his representatives, 8. Ability and agreement to comply with the study requirements, 9. Normal blood pressure and heart rate measured under stabilised conditions at the screening visit after at least 5 minutes of rest under supine position: SBP within 100 to 140 mmHg, DBP within 60 to 90 mmHg and HR within 50 to 90 bpm, 10. Normal/ acceptable 12-lead electrocardiographic results at least after 5 minutes of rest, 11. Laboratory results within normal range or clinically non-significant (CBC, glucose, urea, uric acid, creatinine, estimated GFR (eGFR), total bilirubin, sodium, potassium, calcium, chloride, SGOT (AST), SGPT (ALT), GGT, alkaline phosphatase, total protein and urinalysis), drug addiction scanning in urine results in negative (amphetamine, barbiturate, benzodiazepine, cannabinoid, cocaine, opiate), 12. Understanding of the study and agreement to give a written informed consent according to section 20.3. 13. Volunteer's compliance with isolation rules defined at study protocol  Who have atopic constitution or asthma or known allergy for lopinavir and ritonavir or any other ingredients of the products. 2. Any history or presence of clinical relevance of cardiovascular (myocardial infarction/ ischaemia and/or QT prolongation etc.), neurological, musculoskeletal, haematological, hepatic, gastrointestinal, renal, pulmonary, endocrinological, metabolism or psychiatric disease, any type of porphyria. 3. Baseline ECG should be performed at screening. subjects having a QTc > 440 ms 4. Symptomatic or asymptomatic orthostatic hypotension at screening or before the first drug administration defined by a decrease of SBP more than 20 mmHg or DBD more than 10 mmHg occurs between sitting/supine to standing position subject will be excluded (if it deemed necessary by the investigator), 5. Presence or history of malabsorption or any gastrointestinal surgery except appendectomy or except herniotomy. 6. Subjects who have given more than 400 mL blood within the last two months before the first drug administration and subjects who have participated to any drug research within the last two months before the first drug administration. 7. Subjects suspected to have a high probability of non-compliance to the study procedure and/or completion of the study according to the investigator's judgement. 8. Subjects who used any of prescribed systemic or topical medication (including OTC medication) within 2 weeks (or six elimination half lives of this medication, whichever is longer) before the initiation of the study (except single doses of analgesics which have no drug interaction with study product). 9. Use of any vitamins or herbal products within 7 days prior to the initial dose of the study medication. 10. Subjects who have any chronic disease which might interfere with absorption, distribution, metabolism or excretion of the drug. 11. Subjects who regular consumed of beverages or food containing methylxanthines (e.g. coffee, tea, cola, caffeine, chocolate, sodas,) equivalent to more than 500 mg methylxanthines per day. 12. Subjects who has taken any grapefruit or grapefruit juice during 7 days prior to drug administration, during the study. 13. History of allergic response to heparin. 14. History of drug abuse. 15. History of alcohol abuse and/or regular use of more than 2 units of alcohol per day or 10 units per week and/or positive alcohol breath test results (Note: one unit of alcohol equals 250 mL beer, 125 mL wine or 25 mL spirits). 16. Positive blood test for HBV, HCV and HIV. 17. Who have relationship to the investigator. 18. Who are not suitable to any of criteria. 19. History of difficulty of swallowing. 20. Intake of depot injectable solutions (including study medications) within 6 months before start of the study. 21. Intake of enzyme-inducing, organotoxic or long half-life drugs within 4 weeks before start of the study. 22. Special diet due to any reason, e.g. vegetarian