Patient description: The patient is a 3-day-old female infant with jaundice that started one day ago. She was born at 34w of gestation and kept in an incubator due to her gestational age. Vital signs were reported as: axillary temperature: 36.3°C, heart rate: 154 beats/min, respiratory rate: 37 breaths/min, and blood pressure: 65/33 mm Hg. Her weight is 2.1 kg, length is 45 cm, and head circumference 32 cm. She presents with yellow sclera and icteric body. Her liver and spleen are normal to palpation. Laboratory results are as follows: Serum total bilirubin: 21.02 mg/dL Direct bilirubin of 2.04 mg/dL AST: 37 U/L ALT: 20 U/L GGT: 745 U/L Alkaline phosphatase: 531 U/L Creatinine: 0.3 mg/dL Urea: 29 mg/dL Na: 147 mEq/L K: 4.5 mEq/L CRP: 3 mg/L Complete blood cell count within the normal range. She is diagnosed with neonatal jaundice that may require phototherapy.

Clinical trial eligibility criteria: eligible ages (years): 18.0-65.0,  Dementia Delirium Healthy adult volunteers (18-65 years old) willing to undergo a general health screen consisting of blood pressure, heart rate, respiratory rate, height, weight, temperature, and electrocardiogram will be identified The below parameters must be met to be consider an adult healthy to volunteer for in this study Blood pressure less than 160/99 mmHg and greater than 105/50 mmHg Heart rate between 50-100 beats per minutes Respiratory rate between 10-30 breaths per minute Temperature between 34 °C and 37.5°F Corrected QT interval of < 470 msec Liver function tests less than 1.5 times the upper limit of normal Estimated creatinine clearance (estimated by Cockcroft Gault formulation) greater than 60 mL/min Female participants will complete a urine pregnancy test that must result in a negative finding 1. Allergy to quetiapine, Lipoderm or polyethylene glycol 2. Currently taking quetiapine 3. Pregnant, planning to become pregnant or breast feeding 4. Over or under 30% of ideal body weight 5. History of or active cardiovascular disease (except hypertension meeting the for blood pressure), severe kidney disease (i.e. needing dialysis), or liver disease 6. History of schizophrenia, bipolar disorder, substance use disorders (but excluding nicotine use disorders and stable unipolar depression (See below)) 7. Unstable unipolar depression, defined as hospitalization for depression within 1 year or changes to an antidepressant regimen within 6 months 8. History of seizure or seizure disorder 9. Parkinson's disease, Huntington's disease, tardive dyskinesia or other diagnosed movement disorder 10. History of/or active hematologic/oncologic illness 11. Dementia 12. Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome 13. History of organ transplant 14. History of gastric bypass 15. Contraindications for suppository administration 16. With Ostomy, chronic diarrhea 17. Diabetes, type 1 or type 2 18. Prolong corrected QT interval (>470 msec) or history of congenital long QT syndrome 19. Open wound(s) or unhealed wound(s) at topical medication application site (anterior forearm) 20. Active or latent tuberculous and currently prescribed pharmacotherapy treatments 21. Currently prescribed or taken with in the last 7 days, medications which have a known interaction with quetiapine or compound the risk of adverse events associated with quetiapine