Patient description: The patient is a 55-year-old man diagnosed with HCV 2 years ago and the recent coinfection with HBV. His past medical history is non-significant. He is on IFN, RBV and direct antiviral drugs for the past 6 months. The patient takes no other medications. His medical records show previous positive HCV RNA tests and a positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis, or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-85.0,  Hepatitis C Signed informed consent 2. Clalit insured patients 3. Female and male over the age of 18 4. Capacity to provide written informed consent 5. HCV RNA Viral Load (VL) larger than 105 IU/mL at screening and on at least one other occasion 6 months or more prior to the most recent HCV RNA test result. 6. HCV genotypes 1a, 1b, 2, 3 or 4 7. Liver fibrosis stage 0-4 as determined by one of the following methods performed within 2 years prior to the screening visit: 1. Fibrotest 2. Transient elastography 3. Liver biopsy using the scoring system. 8. Patients must have the following laboratory parameters within 3 months of screening 1. ALT and AST ≤ x10 the upper limit of normal (ULN) 2. Direct bilirubin ≤ 1.5 the ULN 3. Platelet count ≥70,000 4. Hemoglobin ≥10 mg/dL 5. Albumin ≥3 mg/dL 6. INR ≤ 1.5 x ULN 7. eGFR ≥ 60 mL/min as calculated by the Cockroft-Gault equation. 9. Abdominal ultrasound, C.T or MRI scan showing no evidence of a focal lesion suspicious of hepatocellular carcinoma within 6 months of enrollment. 10. A female patient will be eligible to enter the study if it is confirmed that she is: 1. Not pregnant or nursing 2. Of non-childbearing potential (following hysterectomy, bilateral oophorectomy or post-menopausal) 3. Women of childbearing potential must have a negative urine pregnancy test at baseline and willing to use an accepted mechanical, medical or surgical birth control method from the day of screening until 90 days from the last dose of study drug. 11. All male participants in the study must agree to consistently and correctly use a condom, while their female partner agrees to use one of the above-mentioned birth control methods from the day of screening until 90 days after the last dose of study drug. 12. Patient must be able to comply with the dosing instructions for the study drug administration and able to complete the study schedule of assessments including all required post-treatment visits  Clinical, serologic or histopathological evidence supporting the presence of chronic liver disease other than HCV (Including but not limited to: HBV, HDV or HIV coinfection, non-alcoholic steatohepatitis, alcoholic liver disease, Wilson's disease, A1AT deficiency and Celiac disease). Workup performed within 6 months of recruitment will be considered sufficient to the above-mentioned conditions (except for A1AT deficiency and Wilson's disease for which at any time point qualifies). 2. Current or past history of any of the following: 1. Clinically significant illness (other than HCV) or any other medical disorder that may interfere with patient's assessment, treatment or compliance with the protocol. Examples congestive heart disease with moderate to severe left ventricular function and chronic obstructive pulmonary disease requiring chronic corticosteroid therapy. 2. Clinical evidence of decompensated liver disease (e.g. ascites, bleeding esophageal varices, spontaneous bacterial peritonitis, encephalopathy or hepatorenal syndrome.) 3. Child Pugh score higher than 6 4. Gastrointestinal disorder or post-operative condition that may interfere with the absorption of the study drug. 5. Solid organ transplantation 6. Malignancy within 5 years prior to screening with the exception of specific cancers that are entirely cured by surgical resection (basal cell skin cancer etc.) Patients under the evaluation for possible malignancy are not eligible. 3. Any prior treatment with a DAA (protease inhibitors, NS5A inhibitors, NS5B polymerase inhibitors/non-nucleoside polymerase inhibitors) 4. Use of anti-viral medications within 30 days of screening. 5. Chronic use of systemically administered immunosuppressive/immune modulating medications 6. Clinically relevant substance abuse within 6 months of enrollment. Patient with prior history of drug addiction who are currently maintained on a stable dose of opiate substitutes (naloxone) will be allowed to participate in the study if they can provide documentation of repeated negative toxicology screens from the 6 months prior to screening. 7. Participating in clinical trial 30 days before screening