Patient description: The patient is a 60 year old man complaining of frequent headaches, generalized bone pain and difficulty chewing that started 6 years ago and is worsening. Examination shows bilateral swellings around the molars. The swellings have increased since his last examination. Several extraoral lesions are detected in the head and face. The swellings are non-tender and attached to the underlying bone. Further evaluation shows increased uptake of radioactive substance as well as an increase in urinary pyridinoline. His serum alkaline phosphatase is 300 IU/L (the normal range is 44- 147 IU/L). His family history is only significant for hypertension in his mother and DM type 2 in his father. The diagnosis of Paget's Disease of Bone was confirmed and Bisphosphonate will be started as first-line therapy.

Clinical trial eligibility criteria: eligible ages (years): 20.0-999.0,  Carcinoma of the Head and Neck The patient has pathologically proven squamous cell carcinoma arising in the oropharynx, hypopharynx, or larynx. 2. The patient has been confirmed Epidermal Growth Factor Receptor expressing in tumor specimen by immunohistochemistry. 3. The patient has stage III or IV disease (Unio Internationalis Contra Cancrum / International Union against Cancer Tumor-Lymph Nodes-Metastases classification) with an expected survival of ≥ 12 months. 4. The patient has at least bi-dimensionally measurable disease. 5. The patient is medically suitable to withstand a course of the definitive radiation therapy. 6. The patient aged ≥ 20 years old at informed consent 7. The patient's Karnofsky performance status is ≥ 60 8. Hemoglobin ≥ 9g/dL 9. Neutrophil ≥ 1500/mm^3 10. Platelet ≥ 100,000/mm^3 11. Total Bilirubin ≤ 1.5 mg/dL 12. Aspartate Aminotransferase ≤ 2 x the upper limit of normal 13. Alanine Aminotransferase ≤ 2 x the upper limit of normal 14. Serum creatinine ≤ 1.5 mg/dL 15. Serum calcium concentration: within normality 16. The patient is eligible if disease free from a previously treated malignancy for greater than three years. 17. The patient agrees to use effective contraception if procreative potential exists. 18. The patient has given signed informed consent 19. The patient who is a Japanese with Japanese citizenship  The patient has evidence of distant metastatic disease. The patient who has any metastatic disease documented by Magnetic Resonance Imaging for the head and neck, and Computed Tomography for the chest and abdomen should be excluded. 2. The patient has squamous cell carcinoma arising in the nasopharynx or oral cavity. 3. The patient has received prior systemic chemotherapy within the last three years. 4. The patient has undergone previous surgery for the tumor under study other than biopsy. 5. The patient has received prior radiation therapy to the head and neck. 6. The patient's radiation therapy is considered to be a part of a postoperative regimen following primary surgical resection. 7. The patient is pregnant or breast feeding. 8. The patient has received prior Cetuximab or murine monoclonal antibody (including chimeric antibody) therapy or a history of severe hypersensitivity to any component of Cetuximab solution for Injection. 9. The patient has a medical or psychological condition that would not permit the patient to complete the study or sign informed consent (including drug abuse). 10. The patient has uncontrolled diabetes mellitus, malignant hypertension, or liver failure. 11. The patient has or has suffered from a pulmonary fibrosis, acute pulmonary disorder, or interstitial pneumonia. 12. The patient has an active infection (infection requiring intravenous anti-bacterial, anti-fungus, or anti-viral agent), or known and declared Human Immunodeficiency Virus infection. 13. The patient has a clinically relevant coronary artery disease or history of myocardial infarction in the last 12 months or high risk of uncontrolled arrhythmia or uncontrolled cardiac insufficiency 14. The patient has a dental disease which requires incision and drainage. 15. The patient has active multiple cancers (excluding skin cancer except for melanoma, and carcinoma in situ of the cervix or the digestive tract) in the last 3 years. 16. The patient has been received some investigational medication within 30 days before study entry