Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 18.0-70.0,  Pressure Ulcer Subject has had a spinal cord injury and has bilateral lower limb paralysis. 2. Subject cannot contract his/her gluteus muscle voluntarily. 3. Subject is between 18 and 70 years old. 4. Subject sits in a wheelchair for at least 5 hours per day. 5. Attending physician considers the subject in general good health (other than SCI and PU wound). 6. Subject has one or more PUs of Stage III or IV (according to National Pressure Ulcer Advisory Panel Staging1). 7. Subject is having a musculocutaneous (not cutaneous or fasciocutaneous) gluteal rotation flap surgery for PU treatment in which the inferior gluteal pedicle and sciatic nerve will be exposed but not damaged or sacrificed in any way (for any PU wound(s)). 8. Subject is mentally capable of understanding the goals and the application of therapy. 9. Subject is able to apply the therapy (with or without help) once discharged from Rancho Los Amigos. 10. Subject is willing and capable of giving informed consent. 11. Subject is willing and capable of traveling to testing center at the schedules  Subject has a positive pregnancy test, is nursing / lactating, or is planning on becoming pregnant or is unwilling to not become pregnant in the next 12 months. 2. Subject has an electronic implant (e.g. cardiac pacemaker, etc.). 3. Subject has any condition associated with a wound healing abnormality (e.g.: connective tissue disorder, immune disorder, diabetes, clinical obesity). IDE application: BION Active Seating for Pressure Ulcer Prevention Page 65 4. Subject is malnourished. 5. The attending physician has concerns about the healing of this subject (e.g.: heavy smoking, excessive and/or poorly-managed incontinence). 6. Subject has concurrent concomitant condition affecting the buttock/pelvic area, including other pressure wound not corrected by the flap surgery. 7. Subject suffers from claustrophobia or fear of MRI, or has any contraindication to MRI (e.g. metal implants, pacemaker, etc. not suited to MRI). 8. Subject has damage to the inferior or superior gluteal neurovascular pedicles. 9. Subject is / plans to participate in another investigational study that may affect the healing of PUs or prevent their occurrence/recurrence. 10. Subject is using medications / undergoing procedures that will interfere with NMES effecting muscle contraction (e.g. treatments for spasticity and / or spasms, such as: neurotomies, tenotomies, myotomies, and rhizotomies; as well as tranquilizers and muscle relaxant / paralyzing agents such as Baclofen (Lioresal®), Dantrolene (Dantrium®) and Botulinum Toxin Type A (Botox®)). 11. Subjects whose ulcer extends more than 2.25" deep to the projected surface contour of the buttock when the patient is in a prone position (measured perpendicular to the base of the PU, from the deepest point of the PU to the level of the highest point of the buttock surface, when prone) 12. Subject's wheelchair and the BION system have been tested for interference of either with the other's operation, and either does not operate normally when used together, and this cannot be resolved with an available alternate wheelchair