Patient description: Patient is a 34-year-old woman from Jordan who comes to clinic with some general and non-specific bones and joints pain. She is married and has 3 children. Her past medical and drug history are unremarkable. Her BMI is 23, BP: 120/75, HR: 75/min. Her laboratory study is remarkable for Vit D: 14ng/ml and otherwise healthy. (Ca: 9.2mg/dl, Phosphorus: 3.2mg/dl, PTH: 28pg/ml)

Clinical trial eligibility criteria: eligible ages (years): 35.0-70.0,  Arthralgia Healthy male or female volunteers >35 to <70 years of age Non-smoker Body Mass Index (BMI) greater than 30 kg/m2 and less than 45 kg/m2 at screening Willing to maintain current background dietary and physical activity pattern throughout study period Knee joint No knee joint discomfort at rest Experience knee joint discomfort with activity or exercise within the last 2 weeks of at least 30 mm out of 100mm on VAS rating for "knee discomfort with activity or exercise at any time over the last 3 weeks" Must achieve a rating of at least 30mm on a 100mm VAS at any point throughout the standardized lower extremity exercise performance screening test (Screening test = 3 sets of 10-12 repetitions on seated knee extension machine + 3-minute walk test at maximal walking velocity) Non-pregnant, non-lactating females who agree to use effective contraceptive methods throughout the course of the study Females of childbearing potential must agree to use one of the following acceptable birth control methods: 1. Surgically sterile (hysterectomy or bilateral oophorectomy); 2. Surgically sterile (bilateral tubal ligation with surgery at least 6 weeks prior to study initiation); 3. Intrauterine device (IUD) in place for at least 3 months; 4. Abstinence (not having sexual intercourse); 5. Barrier method (condom or diaphragm) with spermicide for at least 14 days prior to screening and through study completion; 6. Vasectomized partner  Subjects with an established diagnosis of inflammatory joint disorder or osteoarthritis per ACR (American College of Rheumatology) guidelines Currently taking, or chronic use within 30 days of anti-inflammatory supplements, Boswellia, Curcumin, Omega-3 fatty acids, Glucosamine, Chondroitin, MSM, or Collagen supplements of any type Daily use of NSAIDs (non-steroidal anti-inflammatory drugs); however, daily use of 81 mg of aspirin (not > 81 mg) for cardioprotection is allowed Upon physical screening by the medical staff, any subject with signs of overt nutrient deficiencies or metabolic abnormalities such as anemia. This will also need to be included in the screening assessment Subjects with a history of knee or hip joint replacement surgery, or any hip or back pain which interferes with walking or exercise testing utilized throughout the study Glucocorticoid (Corticosteroid) injection, hyaluronic acid injection, prolotherapy, or PRP (platelet rich plasma) injection, bone marrow or other regenerative injection in affected knee within 6 months prior to enrollment in study Individual has any recent illness or condition (within 6 months of screening) that the Investigator believes would interfere with his or her ability to provide informed consent, comply with the study protocol, or might confound the interpretation of the study results or put the person at undue risk Known or suspected pregnancy, planned pregnancy, or lactation If the subjects has been treated for any psychiatric illness or hospitalized for such within the past year, upon PI discretion, will be excluded from the study History of allergic reaction or known sensitivity to Terminalia chebula or other chemically related botanical/ herbal products or supplements