Patient description: The patient is a 32-year-old obese woman who came to the clinic with weight concerns. She is 165 cm tall and her weight is 113 kg. She is complaining of sleep apnea, PCO and dissatisfaction with her body shape. She is a high-school teacher married for 5 years. She doesn't use any contraceptive methods for the past 4 months and she had no prior pregnancies. She doesn't smoke or use any drugs. She likes to try diets and exercise to lose weight. She completed the four square step test in 14 seconds. Her BP: 130/80, HR: 195/min and her BMI is: 41.54. Her labs: FBS: 98 mg/dl TG: 150 mg/dl Cholesterol: 180 mg/dl LDL: 90 mg/dl HDL: 35 mg/dl Her cardiac assessment is normal. Her joints and ROM are within normal.

Clinical trial eligibility criteria: eligible ages (years): 18.0-45.0,  Hypercholesterolemia Healthy men or women aged 18 to 45 years old at screening visit; 2. Have the ability to read and understand, volunteer to participate in the study, and signed written informed consent. 3. The body mass index (BMI) at screening visit was in the range of 18 to 30 kg/m2 (inclusive) and the body weight ≥ 50 kg. 4. The sitting blood pressure ≥90/60 mmHg and <140/90 mmHg at screening visit. 5. Serum LDL-C level ≥ 70 mg/dL (1.8 mmol/L) and < 190 mg/dL (4.9 mmol/L) at screening visit. 6. Serum Triglyceride (TG) level < 250 mg/dL (2.8 mmol/L) at screening visit. 7. No fertility [female: documented hysterectomy, bilateral oophorectomy, tubal ligation or other female permanent sterilization, or menopause (menopause for more than one year)], or those with fertility are willing to take, during the entire study period, strict and effective contraceptive measures, in addition, female subjects with fertility should have a negative blood/urine pregnancy test at screening visit  Subjects who meet any of the following will be excluded from the study: 2. Evolocumab and/or Alirocumab, or other targeted drugs to PCSK9, has been used at any time. 3. Any therapeutic or research biological agents has been used during the first 6 months of baseline/random (Day 0). 4. Participated in any clinical study within 3 months prior to baseline/random (Day 0). 5. Any drug or health supplement that affects blood lipids or lipid metabolism during the first 30 days of baseline/random (Day 0), including but not limited to: Probucol, statins (e.g. Atorvastatin, Rosuvastatin, etc.), cholesterol absorption inhibitors (such as Ezetimibe), bile acid sequestrants (such as Cholestyramine), red yeast and hawthorn preparations, fibrates, high-purity fish oil preparations (or omega-fatty acids ≥ 1000 mg / day) and niacin preparation (nicotinic acid ≥ 50 mg), etc. 6. Start a new intense exercise or diet control within 30 days of random (Day 0) or major changes to previous diet and lifestyle (including exercise, smoking and drinking). The following conditions occur before the baseline/random (Day 0) 1 day (ie Day-1) need to be excluded Creatine kinase (CK) ≥ 3 times the upper limit of normal (ULN) (Note: related to exercise), or Urinary cotinine is positive, or Positive alcohol saliva test. 7. Previous or concomitant diseases (such as nephrotic syndrome, liver disease, diabetes, hypothyroidism, etc.) or any clinically significant abnormalities found in physical examinations, laboratory tests, and electrocardiograms, which would make the subject unsuitable for this study. 8. The medical history or clinical evidence indicates that the subject had severe acute or chronic disease (including not limited to: heart, kidney, nerves, endocrine, blood, immunity, infection, metabolic disorders, etc.), and the disease has not been controlled, which may confuse the outcome of the study or put the subject at risk judged by the investigator, The following situations need to be excluded had major surgery in the last 6 months, or has been hospitalized (e.g. infection) in the last 3 months, or donated blood or blood loss ≥500 mL in the past 3 months, or has used any prescription or over-the-counter drugs in the past 1 month. 9. Transplantation History of organs (such as heart, lung, liver, kidney, etc.) Malignant tumors history, except for cervical carcinoma in situ or surgically resected skin cancer (basal cells and squamous epithelial cells) for more than 5 years. 10. Drug abuse or alcohol dependence in the past 1 year. 11. HIV infection, or HIV antibody positive at screening visit. 12. Syphilis infection, or serotonin antibody (TPPA) positive at screening visit. 13. Hepatitis B surface antigen (HBsAg) was positive at screening visit. 14. Hepatitis C virus (HCV) antibody was positive at screening visit. 15. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≥ 2 times the upper limit of normal (ULN); alkaline phosphatase and bilirubin ≥ 1.5 times the upper limit of normal (ULN). 16. Allergy history to mammalian-derived biological agents, including monoclonal antibodies. 17. Women during pregnancy and lactation. 18. Any other investigator believes that the subject is not suitable for the study, such as the subject has potential compliance issues, cannot complete all tests and assessments according to the protocol requirements