Patient description: The patient is a 55-year-old man diagnosed with HCV 2 years ago and the recent coinfection with HBV. His past medical history is non-significant. He is on IFN, RBV and direct antiviral drugs for the past 6 months. The patient takes no other medications. His medical records show previous positive HCV RNA tests and a positive enzyme immunoassay for anti-HCV-antibodies. The recent biopsy was negative for hepatocellular carcinoma and was only remarkable for chronic inflammation compatible with a chronic viral hepatitis. There is no evidence of alcoholic liver disease, bleeding from esophageal varices, hemochromatosis, autoimmune hepatitis, or metabolic liver disease. He is an alert male with no acute distress. His BP: 130/75, HR: 90/min and BMI: 27. His abdomen is soft with no ascites or tenderness. The lower extremities are normal with no edema.

Clinical trial eligibility criteria: eligible ages (years): 18.0-60.0,  Hepatitis C, Chronic Has chronic genotype 1 (subtypes 1a or 1b) or genotype 2 or genotype 3 or genotype 4 (as assessed by HCV Genotype assay 2.0 (LiPA); is a registered trademark of the Siemens Healthcare company.) HCV infection documented by at least 1 measurement of serum HCV RNA >=100,000 IU/mL measured during Screening by the COBAS® High Pure/COBAS TaqMan® HCV Test v2.0 (COBAS and TaqMan are registered trademarks of the Roche Molecular Diagnostics company.) and at least one of the following: Documented HCV serology demonstrating the presence of anti-HCV antibodies at least 6 months before screening; or Documented presence of HCV RNA at least 6 months before screening; or Documented evidence of fibrosis on liver biopsy obtained within 3 years (<36 calendar months) prior to the Day 1visit; or FibroSure/FibroTest >0.28 and <=0.58 at screening (Note: subjects with a FibroTest score <=0.28 may be included as long as they meet any 1 of the other CHC above). Note: Cohorts are genotype specific Agrees to IL28B genotyping The subject is able to understand and is capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form and is likely to complete the study as planned Subjects must be treatment-naïve and have not received prior treatment with any interferon, immunomodulatory agent, or DAA for HCV Male or female aged between 18 and 60 years of age, inclusive, at the time of signing the informed consent A female subject is eligible to participate if she is of: Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy [for this definition, "documented" refers to the outcome of the investigator's/designee's review of the subject's medical history for study as obtained via a verbal interview with the subject or from the subject's medical records]; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MIU/ml and estradiol <40 pg/ml (<147 pmol/L) is confirmatory]. Child-bearing potential with negative pregnancy test as determined by serum hCG test (at Screening and Day -1) and urine hCG test on Day 1 and: Agrees to use one of the contraception methods for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until 28 days post last dose. OR has only same-sex partners, when this is her preferred and usual lifestyle Male subjects with female partners of child-bearing potential must agree to use one of the contraception methods. This criterion must be followed from the time of the first dose of study medication until the follow up visit (14 days post last dose) Body weight >50kg (110 lb) for men and >45kg (99 lb) women and a body mass index (BMI) between 18.5-35 kg/m^2 inclusive will be allowed The subject's systolic blood pressure is inside the range of 90-140 mmHg, and diastolic blood pressure is inside the range of 45-90 mmHg. Heart rate is inside the range of 50-100 bpm for female subjects or 45-100 bpm for male subjects Is otherwise healthy as determined by the medical history, physical examination, ECG findings, and clinical laboratory measurements performed at Screening  History of any illness that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject Family history of prolonged QT syndrome (Torsade de Pointes) or sudden cardiac death; first-degree relative with myocardial infarction at premature age (<=45 years for male relative; <=55 years for female relative) History or other clinical evidence of hypertension, significant or unstable cardiac disease (e.g., prolonged QT syndrome [torsade de pointes], angina, congestive heart failure, myocardial infarction, diastolic dysfunction, significant arrhythmia, coronary heart disease, and/or clinically significant ECG abnormalities) Evidence of cirrhosis, as determined by any 1 of the following: FibroSure/FibroTest score >0.58; or Liver biopsy with a fibrosis stage indicative of cirrhosis as classified by a local pathologist (defined as Knodell >3, Metavir >2, Ishak >4, or Batts and Ludwig >2). Both incomplete and transition to cirrhosis (e.g., Metavir score 3) are considered as cirrhosis; or History of ascites, hepatic encephalopathy, or esophagogastric varices Active malignant disease or history of malignant disease within 5 years before screening, with the exception of successfully treated basal cell carcinoma, squamous cell cancer of the skin, and carcinoma of the cervix in situ Any other cause of significant liver disease in addition to hepatitis C, which may but is not limited to malignancy with hepatic involvement, hepatitis B, druginduced or alcohol-related liver disease, autoimmune hepatitis, hemochromatosis, Wilson's disease, nonalcoholic steatohepatitis, or primary biliary cirrhosis Estimated creatinine clearance ≤50 mL/min using the Cockcroft-Gault equation at screening A medical condition that requires frequent or prolonged use of systemic corticosteroids or immunosuppressive drugs (e.g., severe asthma; severe arthritis or autoimmune conditions; organ transplantation; or acute adrenal insufficiency) History of regular alcohol consumption within 1 month of the study defined as: an average weekly intake of >14 drinks for males or >7 drinks for females. One drink is equivalent to 12 g of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits Unwilling to abstain from alcohol for 48 hours prior to the start of dosing until collection of the final pharmacokinetic sample during each treatment period