semaj83/ctmatch_classification huggingface dataset:
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 50.0-999.0,  Parkinson's Disease Parkinson's disease Subjects Subjects with a clinical diagnosis of idiopathic Parkinson's disease based on the presence of bradykinesia and one or both of the following: rest tremor and/or rigidity On stable medications for at least 4 weeks prior to entering the study and expected to not need any medication changes for the duration of the study Age ≥50 at the time of entry into the study Age of onset of Parkinson's disease 45 years old Asymmetric onset of PD Progressive motor symptoms of PD Hoehn and Yahr stages 1-4 Ability to walk up and down a single stair step  Parkinson's disease Subjects Atypical features indicative of a Parkinson's Plus disorder (Progressive Supranuclear Palsy, Multiple Systems Atrophy, Corticobasal Degeneration) including cerebellar signs, supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs Neuroleptic treatment at time of onset of Parkinsonism Active treatment with a neuroleptic at time of study entry History of multiple strokes with stepwise progression of Parkinsonism History of multiple head injuries Inability to walk without assistance, including a cane, wheelchair, or walker Cognitive dysfunction that would prevent subject's ability to perform virtual reality simulation, speed of processing training, or complete questionnaire Blindness Any medical condition that, based on discretion of the PI, would prevent the subject's ability to participate in the study Control Subjects
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 10.0-999.0,  Malocclusion Permanent mandibular dentition including incisors, canines, premolars, and first molars (includes subjects treated with the extraction of premolars) Mandibular incisors with sound, non-carious buccal enamel and no pretreatment with chemical agents such as hydrogen peroxide  Mental/emotional/developmental disability Inability to give informed consent Cleft lip and/or palate, craniofacial anomaly, or syndrome Obvious oral hygiene issues such as excessive plaque accumulation, gingivitis, and/or pre-existing white spot lesions Prosthodontic or restored substrate extending on the labial surface of mandibular incisors Deep bite Known allergies to any study materials
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 7.0-10.0,  Hand Strength change Absence of skeletal muscle in the upper limbs neurological disorder Absence Informed Consent signed by the responsible with preserved cognitive consent form signed by the volunteer  Having less than 7 years old Having more than 10 years old To present some compromise skeletal muscle in the upper limbs not take part in the research
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease All participants must be 18 years or older. 2. All enrollees must understand and cooperate with requirements of the study and be able to provide written informed consent 3. Individuals with medically stable mild to moderate Parkinson's disease or healthy controls (as determined by enrolling investigator) 4. All participants must not have taken UDCA for 4 weeks prior to the study. 5. Absence of dementia in all subjects, as determined by pre-scanning cognitive assessment  Inability to undergo MRI scanning without sedation and other MRI counterindications, such as metal in the body. 2. Medically unstable conditions 3. Pregnant or lactating or those women of child-bearing age that are not using acceptable forms of contraception 4. Unable to adhere to study protocol as determined by the PI
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Gait Disorders, Neurologic Clinically confirmed patients with idiopathic Parkinson's disease Hoehn & Yahr stage 2.5 or 3 patients Patients with a Mini-Mental Status Examination (MMSE) score of 24 or higher  Patients with severe dyskinesia or on-off fluctuations due to medication Patients who need to change drugs during the study period Patients with sensory abnormalities of the lower limb Patients with vestibular disease or paroxismal vertigo Patients with other neurological or orthopedic disease involving legs, or severe cardiovascular diseases
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-75.0,  Parkinson Disease Parkinson's disease, stage 1,5 to 4 on the Hoehn & Yahr scale, community dwelling, stable medication, being able to walk at least 10 meters, being able to transport to the intervention facility, being able to follow instructions in Swedish  parkinsonism of other origin, color blindness, severely impaired vision or hearing
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Parkinson Disease Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation Social insurance  No affiliation to the social insurance Patients under guardianship
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-55.0,  Eurythmy Therapy Healthy adults 18-55 Years old, signed informed consent available  Any known diseases of the cardiovascular system, allergic reactions to electrode patches in the past, coffee, alcohol or smoking less than 3 hours prior to the study, insufficient knowledge of the German language
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-50.0,  PostTraumatic Stress Disorder Able to give informed consent Right-handed Age between 18-50 years old Physically and neurologically healthy [confirmed by a comprehensive medical history] Current PTSD diagnosis  clinically significant medical or neurologic condition or neurocognitive dysfunction that would affect function and/or task performance and/or interfere with the study protocol any current (or within past 2 months) medical condition requiring medication that would interact with dronabinol or interfere with the study protocol risk of harm to self or others that requires immediate intervention presence of contraindications, current or past allergic or adverse reaction, or known sensitivity to cannabinoid-like substances (dronabinol/marijuana/cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide) lack of fluency in English positive drug screen or alcohol breathalyzer unwilling/unable to sign informed consent document currently pregnant (positive pregnancy test), planning pregnancy, or lactating (women) under 18 or over 50 years of age traumatic brain injury (as defined by The American Congress of Rehabilitation as a person who has had a traumatically induced physiological disruption of brain function (i.e., the head being struck, the head striking an object, and/or the brain undergoing an acceleration/deceleration movement (i.e., whiplash) without direct external trauma to the head), as manifested by at least one of the following: any loss of consciousness; any loss of memory for events immediately before or after the injury; any alteration in mental status at the time of the incident; or focal neurological deficits that may or may not be transient)
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Alzheimer's Disease Lewy Body Dementia Parkinson's Disease Subjects must meet the standard clinical of the syndromes of interest All subjects must have enough cognitive abilities to complete study procedures, which will be operationally defined as having a Mini Mental State Examination (MMSE) score greater or equal to 10 Subjects must be on stable cognitive and psychoactive medication regimen for the preceding four weeks of enrollment Subjects must have a responsible study partner that either lives with them or is in regular contact with them at least 4 out of 7 days per week Subjects must have visual and auditory acuity adequate for testing  Any other condition (other than the primary diagnosis), which in the opinion of the investigators might contribute to the syndrome of dementia or complicate its assessment active medical disorder that could preclude participation in this protocol Women who are pregnant or are breast feeding severe renal impairment as defined by glomerular filtration rate (GFR) less than 30 (may have increased radiation exposure with the DaTscan) Subjects in whom English is not the 1st language Subjects with educational level less than 12 years Subjects who have ever participated in an experimental study with an amyloid targeting agent unless it can be documented that the subject received only placebo during the course of the trial
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 18.0-99.0,  Parkinson Disease Dystonia Essential Tremor FOR Patients diagnosed with a tremor syndrome, including, but not limited to Essential tremor (per definition of the Tremor Research Group) Parkinson disease (per UK Brain Bank criteria) Focal tremor such as isolated head tremor, voice tremor Task-specific tremor such as primary writing tremor Orthostatic tremor Patients with other tremor syndromes such as dystonic tremor, intention tremor, etc Age 18 or older Able to give informed consent  FOR Problematic alcohol use, as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT) History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures History of psychotic disorder, Bipolar Disorder or a current depressive episode History or clinical evidence of another neurologic disorder than a tremor syndrome as defined above, which may interfere with the ability to comply with protocol requirements or interpret the obtained results FOR Have abnormal findings of clinical significance on the neurological examination that may affect the scientific integrity of the study Problematic alcohol use, as defined by a score of 8 or higher on the WHO Alcohol Use Disorders Identification Test (AUDIT) History of a brain tumor, a stroke, traumatic brain injury, epilepsy or a history of seizures History of psychotic disorder, Bipolar Disorder or a current depressive episode
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 25.0-45.0,  Healthy Subjects Age 25-45 years Caucasian or African American No gender preference (anticipate 50% female) Normotensive (screening blood pressure <140/90 mmHg) No history of hypertension, diabetes, stroke, coronary artery disease, kidney disease, cancer, thyroid disease, preeclampsia, or hospitalizations in 6 months Normal screening laboratory values (CMP, TSH, A1c) Normal ECG BMI <25 kg/m2  Pregnancy Breast feeding Any medication or herbal preparation >6oz alcohol/week Tobacco use Illicit drug use Chronic NSAID use Recent steroid use (injected, inhaled, oral) Decongestant use in the past 2 weeks Known sensitivity to infused Angiotensin II or para-amino hippurate
Patient description: A 57-year old farmer was diagnosed with Parkinson's disease a year ago. He experiences slowness of movement and tremors. His past medical history is significant for hypertension and hypercholesterolemia. He lives with his wife. They have three children. He used to be active with planting and taking care of their farm animals before his diagnosis. The patient complains of shaking and slow movement. He had difficulty entering through a door, as he was frozen and needed guidance to step in. His handwriting is getting smaller. He is on Levodopa and Trihexyphenidyl. He stated his medications help with shaking and slow movement. But he still has difficulty initiating movements, stiffness and slowness in general. He is an alert and cooperative man who doesn't have any signs of dementia. He doesn't smoke or use any illicit drugs.

Clinical trial eligibility criteria: eligible ages (years): 45.0-85.0,  Parkinson Disease Age 45 to 85 Diagnosis of Parkinson's Disease using the UK Brain Bank Fine motor impairments (if available, scores 2 and higher on the UPDRS motor examination part III.23 and 24) Medication stable for at least 30 days  Features suggestive of other causes of parkinsonism, including cerebrovascular disease or history of major head trauma Inability to move fingers or hands Hoehn and Yahr stage 4 and higher Ferrous metal implants which may interfere with the MEG data acquisition and/or be an MRI safety concern Dementia Participants engaged in other research studies involving music therapies Participants whose insurance does not cover Occupational Therapy costs or who have no insurance