Patient description: A 34 year old man comes to the clinic complaining of dizziness and severe diarrhea since yesterday. He has returned from an international trip few days ago and was living in a camp in Sudan for a month. He developed abdominal pain followed by bloating and nausea as well as loose bowel movements. Soon he was having profuse watery diarrhea without odor. The stool is watery and white but the patient has no fever. Blood pressure is 95/62 lying down and drops to 75/40 standing. The skin turgor has reduced. HR is 110 and he looks ill with dry mucosa. V. cholerae was seen in dark-field microscopy of a fresh stool specimen. The lab study is as bellow: Sodium 137 meq/L Potassium 2 meq/L Chloride 94meq/L CO2 15 meq/L Fecal leukocytes None seen Fecal occult blood Negative

Clinical trial eligibility criteria: eligible ages (years): 18.0-999.0,  Advanced Adult Primary Liver Cancer Anaplastic Thyroid Cancer Bone Metastases Carcinoma of the Appendix Distal Urethral Cancer Fallopian Tube Cancer Gastrinoma Glucagonoma Inflammatory Breast Cancer Insulinoma Liver Metastases Localized Unresectable Adult Primary Liver Cancer Lung Metastases Male Breast Cancer Malignant Pericardial Effusion Malignant Pleural Effusion Metastatic Gastrointestinal Carcinoid Tumor Metastatic Parathyroid Cancer Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter Newly Diagnosed Carcinoma of Unknown Primary Occult Non-small Cell Lung Cancer Pancreatic Polypeptide Tumor Primary Peritoneal Cavity Cancer Proximal Urethral Cancer Pulmonary Carcinoid Tumor Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Adrenocortical Carcinoma Recurrent Adult Primary Liver Cancer Recurrent Anal Cancer Recurrent Bladder Cancer Recurrent Breast Cancer Recurrent Carcinoma of Unknown Primary Recurrent Cervical Cancer Recurrent Colon Cancer Recurrent Endometrial Carcinoma Recurrent Esophageal Cancer Recurrent Extrahepatic Bile Duct Cancer Recurrent Gallbladder Cancer Recurrent Gastric Cancer Recurrent Gastrointestinal Carcinoid Tumor Recurrent Islet Cell Carcinoma Recurrent Malignant Testicular Germ Cell Tumor Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Non-small Cell Lung Cancer Recurrent Ovarian Epithelial Cancer Recurrent Pancreatic Cancer Recurrent Parathyroid Cancer Recurrent Prostate Cancer Recurrent Rectal Cancer Recurrent Renal Cell Cancer Recurrent Salivary Gland Cancer Recurrent Small Intestine Cancer Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Thyroid Cancer Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter Recurrent Urethral Cancer Recurrent Vaginal Cancer Recurrent Vulvar Cancer Skin Metastases Small Intestine Adenocarcinoma Somatostatinoma Stage III Adenoid Cystic Carcinoma of the Oral Cavity Stage III Adrenocortical Carcinoma Stage III Bladder Cancer Stage III Cervical Cancer Stage III Colon Cancer Stage III Endometrial Carcinoma Stage III Esophageal Cancer Stage III Follicular Thyroid Cancer Stage III Gastric Cancer Stage III Malignant Testicular Germ Cell Tumor Stage III Mucoepidermoid Carcinoma of the Oral Cavity Stage III Ovarian Epithelial Cancer Stage III Pancreatic Cancer Stage III Papillary Thyroid Cancer Stage III Prostate Cancer Stage III Rectal Cancer Stage III Renal Cell Cancer Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Vaginal Cancer Stage III Vulvar Cancer Stage IIIA Anal Cancer Stage IIIA Breast Cancer Stage IIIA Non-small Cell Lung Cancer Stage IIIB Anal Cancer Stage IIIB Breast Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Adenoid Cystic Carcinoma of the Oral Cavity Stage IV Adrenocortical Carcinoma Stage IV Anal Cancer Stage IV Bladder Cancer Stage IV Breast Cancer Stage IV Colon Cancer Stage IV Endometrial Carcinoma Stage IV Esophageal Cancer Stage IV Follicular Thyroid Cancer Stage IV Gastric Cancer Stage IV Mucoepidermoid Carcinoma of the Oral Cavity Stage IV Non-small Cell Lung Cancer Stage IV Ovarian Epithelial Cancer Stage IV Pancreatic Cancer Stage IV Papillary Thyroid Cancer Stage IV Prostate Cancer Stage IV Rectal Cancer Stage IV Renal Cell Cancer Stage IV Salivary Gland Cancer Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Oropharynx Stage IVA Cervical Cancer Stage IVA Vaginal Cancer Stage IVB Cervical Cancer Stage IVB Vaginal Cancer Stage IVB Vulvar Cancer Thyroid Gland Medullary Carcinoma Unresectable Extrahepatic Bile Duct Cancer Unresectable Gallbladder Cancer Urethral Cancer Associated With Invasive Bladder Cancer WDHA Syndrome Patients must have a histologically proven Her2 overexpressing malignancy as determined by any standardized assay currently in clinical use Patients must have measurable or evaluable disease The patient must have failed standard curative and/or palliative therapies for their disease Life expectancy of at least 6 months No concurrent malignancy other than non-melanoma skin carcinoma Adequate hematopoietic, cardiac, renal, and hepatic function Calculated creatinine clearance will be used to assess renal function Karnofsky Performance Status index >= 70% Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation; a woman of childbearing potential is defined as a female who is biologically capable of becoming pregnant Normal cardiac ejection fraction by echocardiogram or MUGA (i.e., greater than OSU lower limit of normal)  History of significant peripheral neuropathy or significant central nervous system disease Brain or central nervous system metastasis at entry Active or unstable cardiovascular disease or cardiac disease requiring drug or device intervention; history of coronary artery disease or congestive heart failure Pregnant or nursing women Surgery, radiotherapy, chemotherapy, or hormonal therapy during the three weeks prior to the initiation of therapy Exposure to any investigational drug within three weeks prior to the start of dosing Concurrent use of systemic corticosteroids Known seropositive for hepatitis B surface antigen Known seropositive for HIV antibody Serious concurrent infection requiring intravenous antibiotic therapy