Patient description: Fernandez is a 41 year man who is a professional soccer player. He came to the clinic with itchy foot. Physical exam revealed localized scaling and maceration between the third and fourth of his right toe. It became inflamed and sore, with mild fissuring. The dorsum and sole of the foot was unaffected. There is no pus or tearing in the affected area. He didn't use ant topical ointment on the lesion and has no positive history for any underlying disease such as DM. He smokes 15 cigarettes per day and drinks a beer per day. His family history is positive for hyperlipidemia in her mother and MI in her father. He is in relation with several partners and use condom during the intercourse. His physical exam and lab studies were normal otherwise. Tinea pedis infection confirmed as his diagnosis by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Clinical trial eligibility criteria: eligible ages (years): 21.0-75.0,  Onychomycosis Due to Trichophyton Rubrum Onychomycosis Due to Trichophyton Mentagrophytes Subjects who are between 21 to 75 years (inclusive) of age Subjects male or female and of any race Subjects who are in good general health and free from any clinically significant disease that might interfere with the study evaluations Subjects with established clinical diagnosis of distal subungual onychomycosis Subjects with at least one or both big toe nails involved with 20-75% infection Subjects with both positive KOH and culture for onychomycosis dermatophytes in screening of nail samples Subjects whose infection is confirmed to be caused by T. rubrum or T. mentagrophytes Subjects who are willing and able to refrain from employing other (non-study) treatments (traditional or alternative) for his or her toenail onychomycosis throughout study participation Subjects who are willing and able to refrain from the use of nail cosmetics such as clear and/or colored nail lacquers throughout study participation Subjects who are willing and able to give written informed consent and able to adhere to procedures and visit schedules  Subjects with presence of dermatophytoma (defined as demarcated and localized thick masses) of fungal hyphae and necrotic keratin between the nail plate and nail bed) on the target nail Subjects with onychomycosis infection involving lunula of the affected toenail(s) or spikes of disease extending to nail matrix in the affected big toenail(s) Subjects with conditions other than distal subungual onychomycosis known to cause abnormal nail appearance such as psoriasis, severe moccasin-type tinea pedis requiring treatment, symptomatic interdigital tinea pedis, lichen planus, or other abnormalities that could result in a clinically abnormal nail Subjects whose foot is too large (larger than US men's size 13) or too small (smaller than US women's size 3) to properly fit into the plasma treatment device Subjects with a history of multiple repeated failures with previous therapies for onychomycosis Subjects whose affected big toenails cannot become normal in the opinion of the investigator Subjects with abnormality of the affected big toenail(s) that could prevent a normal appearing nail if clearing of infection is achieved Subjects with trauma to the affected big toenail(s) as identified by the study doctor Subjects who received topical antifungal treatment of the nails within 2 weeks before study initiation Subjects who received systemic antifungal treatment within 3 months before study initiation