Patient description: The patient is a 42 year-old postmenopausal woman who had a screening sonogram which revealed an abnormality in the right breast. She had no palpable masses on breast exam. Core biopsy was done and revealed a 1.8 cm infiltrating ductal breast carcinoma in the left upper outer quadrant. Lumpectomy was done and the surgical margins were clear. The tumor was HER2-positive and ER/PR negative. Axillary sampling revealed 1 positive lymph node out of 12 sampled. CXR was unremarkable. She is using “well women” multivitamins daily and no other medication. She smokes frequently and consumes alcohol occasionally. She is in a relation with only one partner and has a history of 3 pregnancies and live births. She breastfed all three children.

Clinical trial eligibility criteria: eligible ages (years): 18.0-74.0,  Breast Cancer Triple Negative Breast Cancer Subjects must have histologically or cytologically confirmed invasive breast cancer which meets the following 1. Estrogen Receptor (ER) and Progesterone Receptor (PR)-negative as defined by local standard clinical immunohistochemistry (IHC) < 1%. 2. HER2-negative using local standard testing. Negative is defined as IHC 0 or 1+ (if 2+, must reflex to ISH method). If ISH method is used, ratio < 2 is considered negative. 3. Clinical tumor size of at least 2.1 cm (T2) by palpation or imaging, regardless of the ipsilateral regional lymph node status, or any tumor size but with ipsilateral regional lymph nodes involved by the tumor (any T if ipsilateral regional node positive). Subjects with inflammatory breast cancer are eligible. If bilateral breast cancer is present, the subject is eligible if the contralateral tumor is DCIS only (without any invasive disease on biopsy) or another invasive breast cancer of any size that is also ER, PR and HER2 negative. 4. Any radiographic abnormal ipsilateral regional lymph nodes or any clinically concerning ipsilateral regional lymph nodes with the exception of internal mammary nodes should be sampled with percutaneous biopsy, but no sentinel axillary lymph node mapping/biopsy is allowed before chemotherapy. If clinically node negative (cNO), pre-chemotherapy ipsilateral sentinel axillary lymph node mapping/biopsy is not allowed. 2. Candidate for neoadjuvant chemotherapy. 3. Age > 18 years and < 75 years 4. ECOG Performance Status < 1. 5. Left ventricular ejection fraction (LVEF) ≥ LLN (per institutional normal) determined by 6. Adequate organ and marrow function as determined by study protocol 7. Non Pregnant. Women of childbearing potential must have a negative pregnancy test (HCG serum or urine) within 30 days prior to study registration and to be repeated if not done within 7 days of starting chemotherapy. 1. Female subjects must meet one of the following Natural postmenopausal before the screening visit defined as no menses at any time in the preceding 12 consecutive months, or Prior bilateral oophorectomy or bilateral tubal ligation, or If they are of childbearing potential, agree to practice two effective methods of contraception per discussion with the treating physicians from 2. Male subjects, even if surgically sterilized (i.e., status post vasectomy) must agree to one of the following Practice effective barrier contraception during the entire study treatment period and through 90 days after the last study drug dose, or Agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence (e.g., calendar, ovulation, symptothermal, postovulation methods] and withdrawal are not acceptable methods of contraception.) 8. Ability to understand a written informed consent document, and the willingness to sign it  Prior chemotherapy or radiation therapy for invasive breast cancer within 6 months before registration. 2. Prior investigational drugs or interventions for invasive breast cancer within 6 months before registration are not allowed. Prior participation in window-of-opportunity trials without therapeutic intent is allowed if intervention is no more than 3 weeks duration. 3. Stage IV metastatic breast cancer 4. History of allergic reactions attributed to compounds of similar chemical composition to chemotherapy to be used in this study. 5. Breastfeeding women. Cytotoxic chemotherapy is drug with the potential for teratogenic or abortifacient effects. Due to unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with cytotoxic chemotherapy, breastfeeding should be discontinued. 6. Baseline peripheral neuropathy of severity > grade 1 7. Other invasive cancer diagnosis within the past 5 years other than non-melanoma skin cancer. 8. Prior axillary lymph node dissection that preclude patient from surgical evaluation of axillary lymph node status