id
stringlengths 7
11
| context
stringlengths 24
527
| is_mult_event
bool 2
classes | annotations
list |
|---|---|---|---|
14632592_5 | OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[42]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"myopathy\"]], \"start\": [[50]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"a teenager with familial Mediterranean fever (FMF)\"]], \"start\": [[62]], \"entity_id\": [\"T5\"], \"Age\": {\"text\": [[\"teenager\"]], \"start\": [[64]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"colchicine\"]], \"start\": [[31]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"familial Mediterranean fever\"]], \"start\": [[78]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"colchicine\"]], \"start\": [[31]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
11414270_14 | We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[87]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"succinylcholine\"]], \"start\": [[111]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"succinylcholine\"]], \"start\": [[111]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"fatal hyperkalemia\"]], \"start\": [[68]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"mucositis\"]], \"start\": [[16]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"mucositis\"]], \"start\": [[16]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"fatal\"]], \"start\": [[68]], \"entity_id\": [\"T10\"], \"value\": \"High\"}}"
}
]
}
] |
10928688_1 | Our experience supports hemodialysis for ESRF patients with atenolol toxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"for\"]], \"start\": [[37]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"ESRF patients with atenolol toxicity\"]], \"start\": [[41]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"ESRF\"]], \"start\": [[41]], \"entity_id\": [\"T4\"]}}, \"Treatment\": {\"text\": [[\"hemodialysis\"]], \"start\": [[24]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"hemodialysis\"]], \"start\": [[24]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"atenolol toxicity\"]], \"start\": [[60]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
14679124_1 | Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently versus sequentially: randomized phase III trial in postmenopausal node-positive breast cancer patients. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"administered\"]], \"start\": [[65]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"tamoxifen\"], [\"Epirubicin-cyclophosphamide\"]], \"start\": [[55], [0]], \"entity_id\": [\"T13\", \"T15\"]}, \"Disorder\": {\"text\": [[\"node-positive breast cancer\"]], \"start\": [[157]], \"entity_id\": [\"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"plus\"]], \"start\": [[50]], \"entity_id\": [\"T14\"]}, \"Drug\": {\"text\": [[\"tamoxifen\"], [\"Epirubicin-cyclophosphamide\"]], \"start\": [[55], [0]], \"entity_id\": [\"T13\", \"T15\"]}}]}, \"Subject\": {\"text\": [[\"postmenopausal node-positive breast cancer patients\"]], \"start\": [[142]], \"entity_id\": [\"T10\"]}}"
}
]
}
] |
3628148_1 | Rupture of a cerebral aneurysm associated with nifedipine treatment. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[31]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"nifedipine\"]], \"start\": [[47]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"nifedipine\"]], \"start\": [[47]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"Rupture of a cerebral aneurysm\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
15157248_1 | An immediate hemolytic reaction induced by repeated administration of oxaliplatin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[32]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"immediate hemolytic reaction\"]], \"start\": [[3]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"repeated administration of oxaliplatin\"]], \"start\": [[43]], \"entity_id\": [\"T5\"], \"Freq\": {\"text\": [[\"repeated\"]], \"start\": [[43]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"oxaliplatin\"]], \"start\": [[70]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
15494638_8 | Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[10]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"Patient B\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"perioral and upper extremity paresthesias\"]], \"start\": [[20]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"the fourth cycle of CAP alone (2500 mg/m2)\"]], \"start\": [[69]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"CAP\"]], \"start\": [[89]], \"entity_id\": [\"T9\"]}, \"Freq\": {\"text\": [[\"the fourth cycle\"]], \"start\": [[69]], \"entity_id\": [\"T10\"]}, \"Dosage\": {\"text\": [[\"2500 mg/m2\"]], \"start\": [[100]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
8749646_4 | We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[49]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ofloxacin\"]], \"start\": [[59]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"ofloxacin\"]], \"start\": [[59]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"seizures\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"four patients\"]], \"start\": [[12]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"four\"]], \"start\": [[12]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
14607011_2 | The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"involving\"]], \"start\": [[66]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"pseudoephedrine, brompheniramine, and dextromethorphan\"]], \"start\": [[76]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"pseudoephedrine\"], [\"brompheniramine\"], [\"dextromethorphan\"]], \"start\": [[76], [93], [114]], \"entity_id\": [\"T10\", \"T11\", \"T12\"]}}, \"Effect\": {\"text\": [[\"infant fatality\"]], \"start\": [[50]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"an infant\"]], \"start\": [[47]], \"entity_id\": [\"T13\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[50]], \"entity_id\": [\"T14\"]}}}"
}
]
}
] |
9701106_1 | A drug interaction between zafirlukast and theophylline. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"between\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"drug interaction\"]], \"start\": [[2]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"zafirlukast and theophylline\"]], \"start\": [[27]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"zafirlukast\"], [\"theophylline\"]], \"start\": [[27], [43]], \"entity_id\": [\"T7\", \"T8\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"zafirlukast\"], [\"theophylline\"]], \"start\": [[27], [43]], \"entity_id\": [\"T7\", \"T8\"]}}]}}"
}
]
}
] |
16503727_1 | Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"association\"]], \"start\": [[154]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"agranulocytosis\"]], \"start\": [[171]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Dipyrone, also known as metamizole\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Dipyrone\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
990658_1 | A fatal case of pancytopenia due to levomepromazine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[29]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"pancytopenia\"]], \"start\": [[16]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"levomepromazine\"]], \"start\": [[36]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"levomepromazine\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"A fatal case\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
20130478_2 | Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[25]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Reversible heart failure\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[28]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"etanercept\"]], \"start\": [[48]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"etanercept\"]], \"start\": [[48]], \"entity_id\": [\"T6\"]}, \"Disorder\": {\"text\": [[\"ankylosing spondylitis\"]], \"start\": [[63]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
12503933_7 | The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[16]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"liver failure\"]], \"start\": [[25]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"clarithromycin\"]], \"start\": [[71]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"clarithromycin\"]], \"start\": [[71]], \"entity_id\": [\"T8\"]}}, \"Speculated\": {\"text\": [[\"likely\"]], \"start\": [[9]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
15554737_2 | Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[50]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"Localized panniculitis and subsequent lipoatrophy\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"subcutaneous glatiramer acetate (Copaxone) injection\"]], \"start\": [[55]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"glatiramer acetate (Copaxone)\"]], \"start\": [[68]], \"entity_id\": [\"T11\"]}, \"Route\": {\"text\": [[\"injection\"]], \"start\": [[98]], \"entity_id\": [\"T12\"]}, \"Disorder\": {\"text\": [[\"multiple sclerosis\"]], \"start\": [[129]], \"entity_id\": [\"T13\"]}}}"
}
]
}
] |
19224802_6 | glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulting\"]], \"start\": [[40]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"glycopyrrolate (5.0 microg/kg)\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"glycopyrrolate\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}, \"Dosage\": {\"text\": [[\"5.0 microg/kg\"]], \"start\": [[16]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"resolution of bradycardia\", \"an exaggerated increase of arterial blood pressure\"]], \"start\": [[53, 101]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
16511396_3 | This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"hypersensitivity\"]], \"start\": [[72]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"sulfadiazine\"]], \"start\": [[59]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"sulfadiazine\"]], \"start\": [[59]], \"entity_id\": [\"T5\"]}}, \"Effect\": {\"text\": [[\"hypersensitivity\"]], \"start\": [[72]], \"entity_id\": [\"T6\"]}}"
},
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"from\"]], \"start\": [[118]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"immunosuppression\"]], \"start\": [[100]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"corticosteroids\"]], \"start\": [[123]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"corticosteroids\"]], \"start\": [[123]], \"entity_id\": [\"T10\"]}}, \"Speculated\": {\"text\": [[\"potential\"]], \"start\": [[90]], \"entity_id\": [\"T12\"], \"value\": true}}"
}
]
}
] |
10084639_2 | CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treating\"]], \"start\": [[65]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"olanzapine\"]], \"start\": [[37]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"olanzapine\"]], \"start\": [[37]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"without the risk of recurrence of hematologic side effects\"]], \"start\": [[123]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"patients with clozapine-induced granulocytopenia\"]], \"start\": [[74]], \"entity_id\": [\"T5\"]}}"
},
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[98]], \"entity_id\": [\"T12\"]}, \"Treatment\": {\"text\": [[\"clozapine\"]], \"start\": [[88]], \"entity_id\": [\"T13\"], \"Disorder\": {\"text\": [[\"clozapine-induced granulocytopenia\"]], \"start\": [[88]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"clozapine\"]], \"start\": [[88]], \"entity_id\": [\"T15\"]}}, \"Effect\": {\"text\": [[\"granulocytopenia\"]], \"start\": [[106]], \"entity_id\": [\"T14\"]}}"
}
]
}
] |
10452772_1 | CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"resolution\"]], \"start\": [[64]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"standard desensitization\"]], \"start\": [[99]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"Patients with insulin allergy\", \"concomitant protamine allergy\"]], \"start\": [[12, 158]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"insulin allergy\"], [\"protamine allergy\"]], \"start\": [[26], [170]], \"entity_id\": [\"T7\", \"T10\"]}}, \"Negated\": {\"text\": [[\"not\"]], \"start\": [[46]], \"entity_id\": [\"T6\"], \"value\": true}}"
}
]
}
] |
2394154_4 | To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[85]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"fever, pulmonary infiltrates, and pleural effusion\"]], \"start\": [[34]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"acyclovir\"]], \"start\": [[102]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"acyclovir\"]], \"start\": [[102]], \"entity_id\": [\"T11\"]}}, \"Negated\": {\"text\": [[\"not\"]], \"start\": [[116]], \"entity_id\": [\"T10\"], \"value\": true}}"
}
]
}
] |
3485422_2 | We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"of\"]], \"start\": [[68]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"macular lesion\"]], \"start\": [[26]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"gentamicin\"]], \"start\": [[71]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"gentamicin\"]], \"start\": [[71]], \"entity_id\": [\"T7\"]}}, \"Speculated\": {\"text\": [[\"concerned\"]], \"start\": [[7]], \"entity_id\": [\"T6\"], \"value\": true}}"
}
]
}
] |
16791713_1 | Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[28]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"high-dose methylprednisolone therapy\"]], \"start\": [[35]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"methylprednisolone\"]], \"start\": [[45]], \"entity_id\": [\"T6\"]}, \"Disorder\": {\"text\": [[\"Graves' ophthalmopathy\"]], \"start\": [[76]], \"entity_id\": [\"T7\"]}, \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[35]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Acute myocardial infarction\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Severity\": {\"text\": [[\"Acute\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": \"High\"}}"
}
]
}
] |
11881322_8 | With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reported\"]], \"start\": [[68]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"itraconazole\"]], \"start\": [[5]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"itraconazole\"]], \"start\": [[5]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"hepatotoxic\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
17675030_4 | We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[109]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"oxcarbazepine\"]], \"start\": [[124]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"oxcarbazepine\"]], \"start\": [[124]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"angioedema\"]], \"start\": [[91]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a 4(1/2)-year-old boy\"]], \"start\": [[53]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"4(1/2)-year-old\"]], \"start\": [[55]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[71]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
21045170_11 | Caution should be used when coadministering enfuvirtide and niacin to HIV-infected patients. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"used\"]], \"start\": [[18]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"Caution\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"HIV-infected patients\"]], \"start\": [[70]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"coadministering enfuvirtide and niacin\"]], \"start\": [[28]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"enfuvirtide\"], [\"niacin\"]], \"start\": [[44], [60]], \"entity_id\": [\"T13\", \"T14\"]}, \"Disorder\": {\"text\": [[\"HIV\"]], \"start\": [[70]], \"entity_id\": [\"T1\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"coadministering\"]], \"start\": [[28]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"enfuvirtide\"], [\"niacin\"]], \"start\": [[44], [60]], \"entity_id\": [\"T13\", \"T14\"]}}]}}"
}
]
}
] |
448845_3 | Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reports\"]], \"start\": [[13]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"aplastic anemia\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"acetazolamide\"]], \"start\": [[52]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"acetazolamide\"]], \"start\": [[52]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"Several case\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"Population\": {\"text\": [[\"Several\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
17381671_7 | SSRIs and fentanyl are commonly co-administered, especially in the setting of chronic or malignant pain, as underlying depression may contribute to the pathogenesis of pain. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[60]], \"entity_id\": [\"T13\"]}, \"Treatment\": {\"text\": [[\"SSRIs and fentanyl are commonly co-administered\"]], \"start\": [[0]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"chronic or malignant pain\", \"underlying depression\"]], \"start\": [[78, 108]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"SSRIs\"], [\"fentanyl\"]], \"start\": [[0], [10]], \"entity_id\": [\"T14\", \"T15\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[6]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"SSRIs\"], [\"fentanyl\"]], \"start\": [[0], [10]], \"entity_id\": [\"T14\", \"T15\"]}}]}}"
}
]
}
] |
1420650_2 | In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"triggered\"]], \"start\": [[122]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"four patients\"]], \"start\": [[26]], \"entity_id\": [\"T4\"], \"Population\": {\"text\": [[\"four\"]], \"start\": [[26]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"asterixis\"]], \"start\": [[108]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"carbamazepine\"]], \"start\": [[149]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"carbamazepine\"]], \"start\": [[149]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
458006_1 | Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[60]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[73]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[73]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"Squamous-cell carcinoma arising\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
8313300_2 | The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"on\"]], \"start\": [[90]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[93]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[93]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"bipolar\"]], \"start\": [[14]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"The case of a bipolar patient\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"thyrotoxicosis with severe exophthalmos\"]], \"start\": [[44]], \"entity_id\": [\"T11\"]}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[64]], \"entity_id\": [\"T13\"], \"value\": \"High\"}}"
}
]
}
] |
1267457_2 | The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[90]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"ophthalmic sulfonamide, and it was used for one day\"]], \"start\": [[30]], \"entity_id\": [\"T3\"], \"Route\": {\"text\": [[\"ophthalmic\"]], \"start\": [[30]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"sulfonamide\"]], \"start\": [[41]], \"entity_id\": [\"T9\"]}, \"Duration\": {\"text\": [[\"one day\"]], \"start\": [[74]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"The patient\", \"he\"]], \"start\": [[0, 87]], \"entity_id\": [\"T4\"], \"Gender\": {\"text\": [[\"he\"]], \"start\": [[87]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Stevens-Johnson syndrome\"]], \"start\": [[100]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
11545487_3 | Papillary necrosis associated with the HIV protease inhibitor indinavir. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"indinavir\"]], \"start\": [[62]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"indinavir\"]], \"start\": [[62]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"HIV\"]], \"start\": [[39]], \"entity_id\": [\"T1\"]}}, \"Effect\": {\"text\": [[\"Papillary necrosis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
8360712_1 | A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[108]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a 40 year old woman\"]], \"start\": [[22]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"40 year old\"]], \"start\": [[24]], \"entity_id\": [\"T8\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[36]], \"entity_id\": [\"T9\"]}}, \"Treatment\": {\"text\": [[\"intraventricular IL-2\"]], \"start\": [[55]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"leptomeningeal disease\"]], \"start\": [[81]], \"entity_id\": [\"T4\"]}, \"Drug\": {\"text\": [[\"IL-2\"]], \"start\": [[72]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"intraventricular\"]], \"start\": [[55]], \"entity_id\": [\"T1\"]}}, \"Effect\": {\"text\": [[\"progressive cognitive dysfunction\"]], \"start\": [[118]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
15289139_3 | We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[23]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"extensive choroidal detachment\"]], \"start\": [[41]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"dorzolamide therapy\"]], \"start\": [[92]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dorzolamide\"]], \"start\": [[92]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"surgically untreated eye with primary open-angle glaucoma\"]], \"start\": [[117]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"surgically untreated eye with primary open-angle glaucoma\"]], \"start\": [[117]], \"entity_id\": [\"T6\"]}, \"Severity\": {\"text\": [[\"abrupt\"], [\"extensive\"]], \"start\": [[16], [41]], \"entity_id\": [\"T8\", \"T11\"], \"value\": \"High\"}}"
}
]
}
] |
19226083_1 | Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"consequence\"]], \"start\": [[24]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Serotonin toxicity\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"linezolid use in revision hip arthroplasty\", \"Serotonin\"]], \"start\": [[39, 0]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Serotonin\"], [\"linezolid\"]], \"start\": [[0], [39]], \"entity_id\": [\"T7\", \"T8\"]}}}"
}
]
}
] |
11788010_2 | Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"side effects of\"]], \"start\": [[38]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Gallstones and bile sludge\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"octreotide therapy\"]], \"start\": [[54]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"octreotide\"]], \"start\": [[54]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
14557583_3 | The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[45]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"some patients with Parkinson's disease\"]], \"start\": [[73]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"daytime somnolence\"]], \"start\": [[51]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"L-dopa\"]], \"start\": [[34]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"L-dopa\"]], \"start\": [[34]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"Parkinson's disease\"]], \"start\": [[92]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
8597009_2 | Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"had\"]], \"start\": [[153]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"blood levels in the toxic range\"]], \"start\": [[157]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"phenytoin\"]], \"start\": [[124]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"phenytoin\"]], \"start\": [[124]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"epileptogenic\"]], \"start\": [[39]], \"entity_id\": [\"T12\"]}}, \"Subject\": {\"text\": [[\"Seventy-four per cent of patients with epileptogenic disorders\", \"11.6% of these\"]], \"start\": [[0, 138]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"Seventy-four per cent\"], [\"11.6%\"]], \"start\": [[0], [138]], \"entity_id\": [\"T7\", \"T9\"]}}}"
}
]
}
] |
16284443_1 | Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[67]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"insulin\"]], \"start\": [[59]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"insulin\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lipohypertrophy\"]], \"start\": [[75]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
16637972_2 | An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[66]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"spontaneous sub-conjunctival haematoma\"]], \"start\": [[27]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[69]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"warfarin\"]], \"start\": [[89]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"warfarin\"]], \"start\": [[89]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
19782276_4 | He developed congestive heart failure 5 days after administration of cyclophosphamide. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[3]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"congestive heart failure\"]], \"start\": [[13]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"5 days after administration of cyclophosphamide\"]], \"start\": [[38]], \"entity_id\": [\"T6\"], \"Time_elapsed\": {\"text\": [[\"5 days\"]], \"start\": [[38]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"cyclophosphamide\"]], \"start\": [[69]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
12503933_5 | Fulminant liver failure associated with clarithromycin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[24]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Fulminant liver failure\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"clarithromycin\"]], \"start\": [[40]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"clarithromycin\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
2979256_3 | Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induce, or aggravate\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Nifedipine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Nifedipine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"gastro-oesophageal reflux\"]], \"start\": [[51]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
2728526_1 | Rifampin-associated thrombocytopenia secondary to poor compliance. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[9]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Rifampin\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Rifampin\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"thrombocytopenia secondary to poor compliance\"]], \"start\": [[20]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
8672829_2 | CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"relationship\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"onset of nonconvulsive status epilepticus\"]], \"start\": [[59]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"initiation of ifosfamide infusion\"]], \"start\": [[105]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ifosfamide\"]], \"start\": [[119]], \"entity_id\": [\"T7\"]}, \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[130]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
16109609_1 | Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[12]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Gemcitabine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Gemcitabine\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"unblocked cardiac irradiation\"]], \"start\": [[61]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"pericardial effusion and tamponade\"]], \"start\": [[20]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
7416268_3 | Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[90]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"disulfiram\"]], \"start\": [[57]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"disulfiram\"]], \"start\": [[57]], \"entity_id\": [\"T11\"]}, \"Disorder\": {\"text\": [[\"chronic alcoholism\"]], \"start\": [[37]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"a wide spectrum of side effects and untoward medical sequelae, which now include catatonia\"]], \"start\": [[106]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
19567656_2 | DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"relationship\"]], \"start\": [[63]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"sertraline\"]], \"start\": [[84]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"sertraline\"]], \"start\": [[84]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"rhabdomyolysis\"]], \"start\": [[122]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"probable\"]], \"start\": [[54]], \"entity_id\": [\"T3\"], \"value\": true}}"
}
]
}
] |
14677199_1 | Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[28]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Raynaud's phenomenon\"]], \"start\": [[7]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"yohimbine\"]], \"start\": [[33]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"yohimbine\"]], \"start\": [[33]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"erectile dysfunction\"]], \"start\": [[55]], \"entity_id\": [\"T8\"]}}, \"Severity\": {\"text\": [[\"Severe\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": \"High\"}}"
}
]
}
] |
10323129_1 | Possible theophylline toxicity during anesthesia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[31]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"anesthesia\"]], \"start\": [[38]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"anesthesia\"]], \"start\": [[38]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"theophylline toxicity\"]], \"start\": [[9]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"Possible\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
3124393_2 | Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[55]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Calcification and ossification of the spinal arachnoid\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"intrathecal administration of Depo-Medrol\"]], \"start\": [[61]], \"entity_id\": [\"T7\"], \"Route\": {\"text\": [[\"intrathecal\"]], \"start\": [[61]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"Depo-Medrol\"]], \"start\": [[91]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
921427_2 | Circulating anticoagulant in the procainamide-induced lupus syndrome. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[46]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"procainamide\"]], \"start\": [[33]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"procainamide\"]], \"start\": [[33]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lupus syndrome\"]], \"start\": [[54]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
16405935_3 | This report describes a case of bilateral ptosis induced by chloroquine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[22]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"bilateral ptosis\"]], \"start\": [[32]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"chloroquine\"]], \"start\": [[60]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"chloroquine\"]], \"start\": [[60]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
12221670_5 | When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"proposed\"]], \"start\": [[166]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"57 patients\"]], \"start\": [[21]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"57\"]], \"start\": [[21]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"cytotoxic effect\"]], \"start\": [[68]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ticlopidine\"]], \"start\": [[88]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ticlopidine\"]], \"start\": [[88]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
17526968_3 | We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[75]], \"entity_id\": [\"T12\"]}, \"Subject\": {\"text\": [[\"a child with yolk sac tumor\"]], \"start\": [[10]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"child\"]], \"start\": [[12]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"localized pigmentation\"]], \"start\": [[52]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin\"]], \"start\": [[81]], \"entity_id\": [\"T11\"], \"Duration\": {\"text\": [[\"the first course\"]], \"start\": [[81]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"cisplatin\"], [\"etoposide\"], [\"bleomycin\"]], \"start\": [[136], [147], [161]], \"entity_id\": [\"T17\", \"T18\", \"T19\"]}, \"Disorder\": {\"text\": [[\"yolk sac tumor\"]], \"start\": [[23]], \"entity_id\": [\"T20\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"included\"]], \"start\": [[127]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"cisplatin\"], [\"etoposide\"], [\"bleomycin\"]], \"start\": [[136], [147], [161]], \"entity_id\": [\"T17\", \"T18\", \"T19\"]}}]}}"
}
]
}
] |
16791713_2 | Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[22]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"hypothyroidism\"]], \"start\": [[7]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"radioiodine treatment (euthyroid under substitutional therapy)\"]], \"start\": [[28]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"radioiodine\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"she\"]], \"start\": [[92]], \"entity_id\": [\"T5\"], \"Gender\": {\"text\": [[\"she\"]], \"start\": [[92]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
17034541_1 | Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[43]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"rituximab\"]], \"start\": [[49]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"low-grade cutaneous B-cell lymphoma\"]], \"start\": [[72]], \"entity_id\": [\"T5\"]}, \"Drug\": {\"text\": [[\"rituximab\"]], \"start\": [[49]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Late lethal hepatitis B virus reactivation\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
15482394_3 | Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[166]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"low dosage of warfarin\"]], \"start\": [[12]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"warfarin\"]], \"start\": [[26]], \"entity_id\": [\"T6\"]}, \"Dosage\": {\"text\": [[\"low dosage\"], [\"1.15\"], [\"11.28\"]], \"start\": [[12], [100], [108]], \"entity_id\": [\"T7\", \"T8\", \"T9\"]}, \"Duration\": {\"text\": [[\"4 days\"]], \"start\": [[123]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"international normalized ratio (INR) was markedly elevated\", \"bleeding symptoms\"]], \"start\": [[36, 135]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
3815268_2 | The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"role\"]], \"start\": [[13]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"this patient\"]], \"start\": [[75]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"interferon beta\"]], \"start\": [[21]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"interferon beta\"]], \"start\": [[21]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"sarcoidosis\"]], \"start\": [[60]], \"entity_id\": [\"T3\"]}, \"Speculated\": {\"text\": [[\"possible\"]], \"start\": [[4]], \"entity_id\": [\"T6\"], \"value\": true}}"
}
]
}
] |
11144696_11 | We hypothesize that a pharmacodynamic or pharmacokinetic drug interaction between venlafaxine and trimipramine involving the CYP2D6 isoenzyme may have played a role in inducing the seizures. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"inducing\"]], \"start\": [[168]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"seizures\"]], \"start\": [[181]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"venlafaxine and trimipramine\"]], \"start\": [[82]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"venlafaxine\"], [\"trimipramine\"]], \"start\": [[82], [98]], \"entity_id\": [\"T13\", \"T14\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[94]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"venlafaxine\"], [\"trimipramine\"]], \"start\": [[82], [98]], \"entity_id\": [\"T13\", \"T14\"]}}]}, \"Speculated\": {\"text\": [[\"may\"], [\"hypothesize\"]], \"start\": [[142], [3]], \"entity_id\": [\"T10\", \"T11\"], \"value\": true}}"
}
]
}
] |
2116935_3 | A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[67]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"severe splenic hemorrhage and rupture\"]], \"start\": [[23]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"3 h after completion of tPA infusion\"]], \"start\": [[77]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"suspected acute myocardial infarction\"]], \"start\": [[118]], \"entity_id\": [\"T10\"]}, \"Time_elapsed\": {\"text\": [[\"3 h\"]], \"start\": [[77]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"tPA\"]], \"start\": [[101]], \"entity_id\": [\"T13\"]}, \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[105]], \"entity_id\": [\"T14\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[23]], \"entity_id\": [\"T11\"], \"value\": \"High\"}}"
}
]
}
] |
15383642_6 | Three weeks later, the decerebrate rigidity and high BP remained, and tizanidine was initiated to see whether the decrease in muscle tone could facilitate hypertension control and motor recovery. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"initiated\"]], \"start\": [[85]], \"entity_id\": [\"T12\"]}, \"Subject\": {\"text\": [[\"decerebrate rigidity and high BP\"]], \"start\": [[23]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"tizanidine\"]], \"start\": [[70]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"tizanidine\"]], \"start\": [[70]], \"entity_id\": [\"T16\"]}, \"Disorder\": {\"text\": [[\"decerebrate rigidity and high BP\"]], \"start\": [[23]], \"entity_id\": [\"T17\"]}}, \"Effect\": {\"text\": [[\"hypertension control and motor recovery\"]], \"start\": [[155]], \"entity_id\": [\"T13\"]}, \"Speculated\": {\"text\": [[\"to see whether\"]], \"start\": [[95]], \"entity_id\": [\"T15\"], \"value\": true}}"
}
]
}
] |
1635565_2 | CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[68]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"prostaglandin E1\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"prostaglandin E1\"]], \"start\": [[35]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"neonates\"]], \"start\": [[55]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"neonates\"]], \"start\": [[55]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"gastric-outlet obstruction due to antral hyperplasia\"]], \"start\": [[74]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
8013261_1 | During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[67]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"IFN therapy\"]], \"start\": [[17]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"IFN therapy\"]], \"start\": [[17]], \"entity_id\": [\"T6\"]}, \"Time_elapsed\": {\"text\": [[\"During and after\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"IDDM as well as other autoimmune diseases\"]], \"start\": [[81]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
9754850_1 | In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resolved\"]], \"start\": [[32]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"withdrawal of olanzapine and substitution by a classical\", \"neuroleptic agent\"]], \"start\": [[47, 119]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"olanzapine\"], [\"neuroleptic agent\"]], \"start\": [[61], [119]], \"entity_id\": [\"T6\", \"T7\"]}}, \"Effect\": {\"text\": [[\"akathisia\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"two of these cases\"]], \"start\": [[3]], \"entity_id\": [\"T9\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[3]], \"entity_id\": [\"T10\"]}}}"
},
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resolved\"]], \"start\": [[32]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"akathisia\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"withdrawal of olanzapine and substitution by\", \"an atypical neuroleptic agent\"]], \"start\": [[47, 107]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
3310776_2 | Captopril-related (and -induced?) asthma. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[10]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Captopril\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Captopril\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"asthma\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
15671134_3 | These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[38]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"clozapine\"]], \"start\": [[28]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"clozapine\"]], \"start\": [[28]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"seizures\"]], \"start\": [[46]], \"entity_id\": [\"T5\"]}}"
},
{
"event_id": "E2",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[75]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"gradual dose titration\", \"concomitant use of a suitable mood stabilizer/anti-epileptic medication\"]], \"start\": [[89, 179]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"clozapine-induced seizures\"]], \"start\": [[28]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"the likelihood of further episodes of seizures\", \"improve the outcome of treatment-resistant schizophrenia\"]], \"start\": [[123, 255]], \"entity_id\": [\"T10\"]}}"
}
]
}
] |
18094347_1 | According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[78]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"papular eruption\"]], \"start\": [[48]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\": [[88]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[88]], \"entity_id\": [\"T6\"]}}, \"Speculated\": {\"text\": [[\"probably\"]], \"start\": [[69]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
3688031_3 | The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[29]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"methimazole\"]], \"start\": [[36]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"methimazole\"]], \"start\": [[36]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"teratogenicity\"]], \"start\": [[48]], \"entity_id\": [\"T4\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[22]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
11881322_2 | CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[26]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"Itraconazole\"]], \"start\": [[13]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"Itraconazole\"]], \"start\": [[13]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia\"]], \"start\": [[34]], \"entity_id\": [\"T11\"]}}"
}
]
}
] |
12243603_8 | Rhabdomyolysis resulting from the drug interaction between diltiazem and other HMG-CoA reductase inhibitors has been described in the literature. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulting\"]], \"start\": [[15]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Rhabdomyolysis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"diltiazem and other HMG-CoA reductase inhibitors\"]], \"start\": [[59]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"diltiazem\"], [\"HMG-CoA reductase inhibitors\"]], \"start\": [[59], [79]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interaction\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"diltiazem\"], [\"HMG-CoA reductase inhibitors\"]], \"start\": [[59], [79]], \"entity_id\": [\"T10\", \"T11\"]}}]}}"
}
]
}
] |
23552010_1 | Acute angioedema response to topical 5-fluorouracil therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"response\"]], \"start\": [[17]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"angioedema\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[37]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[37]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
3569037_3 | Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[27]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Hypersensitivity reactions\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"chloramphenicol\"]], \"start\": [[34]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"chloramphenicol\"]], \"start\": [[34]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
18515982_3 | Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[68]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"sclerosing glomerulonephritis\"]], \"start\": [[13]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"patient\"]], \"start\": [[60]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"anastrozole\"]], \"start\": [[75]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"anastrozole\"]], \"start\": [[75]], \"entity_id\": [\"T8\"]}}, \"Speculated\": {\"text\": [[\"suggesting\"]], \"start\": [[92]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
582099_1 | A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated with\"]], \"start\": [[43]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"intrathecally administered amphotericin B\"]], \"start\": [[56]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"coccidioidal meningitis\"]], \"start\": [[15]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"amphotericin B\"]], \"start\": [[83]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"intrathecally\"]], \"start\": [[56]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"an acute toxic delirium with EEG abnormalities\"]], \"start\": [[103]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A patient with coccidioidal meningitis\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
18801826_5 | This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"association\"]], \"start\": [[117]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"non-ketotic, hyperosmolar diabetic coma\", \"hyperglycaemia and hyperthermia\"]], \"start\": [[43, 137]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"antipsychotics\"]], \"start\": [[88]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"antipsychotics\"]], \"start\": [[88]], \"entity_id\": [\"T12\"]}}, \"Speculated\": {\"text\": [[\"possible\"]], \"start\": [[108]], \"entity_id\": [\"T13\"], \"value\": true}}"
}
]
}
] |
10203437_8 | CONCLUSIONS: Reversible lupus-like syndrome appears to be a rare but significant side effect of 5-ASA compounds. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"side effect\"]], \"start\": [[81]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"5-ASA\"]], \"start\": [[96]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"5-ASA\"]], \"start\": [[96]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"Reversible lupus-like syndrome\"]], \"start\": [[13]], \"entity_id\": [\"T8\"]}, \"Speculated\": {\"text\": [[\"appears\"]], \"start\": [[44]], \"entity_id\": [\"T10\"], \"value\": true}}"
}
]
}
] |
267281_1 | A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[79]], \"entity_id\": [\"T12\"]}, \"Subject\": {\"text\": [[\"A patient with chronic myeloid leukaemia\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"busulphan for 4-5 years\"]], \"start\": [[54]], \"entity_id\": [\"T11\"], \"Duration\": {\"text\": [[\"4-5 years\"]], \"start\": [[68]], \"entity_id\": [\"T14\"]}, \"Drug\": {\"text\": [[\"busulphan\"]], \"start\": [[54]], \"entity_id\": [\"T15\"]}, \"Disorder\": {\"text\": [[\"chronic myeloid leukaemia\"]], \"start\": [[15]], \"entity_id\": [\"T16\"]}}, \"Effect\": {\"text\": [[\"busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice\"]], \"start\": [[98]], \"entity_id\": [\"T13\"]}}"
}
]
}
] |
8828999_4 | Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[25]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"lithium\", \"\\\"therapeutic\\\" lithium serum levels\"]], \"start\": [[17, 137]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"lithium\"], [\"lithium\"]], \"start\": [[17], [151]], \"entity_id\": [\"T9\", \"T10\"]}}, \"Effect\": {\"text\": [[\"Creutzfeldt-Jakob syndrome\"]], \"start\": [[33]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"elderly patients\"]], \"start\": [[105]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"elderly\"]], \"start\": [[105]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
11206417_3 | There is, however, currently no data on the effect of combined hyperglycaemia and hyperinsulinaemia on the renal and ocular blood flow seen in diabetic patients on insulin therapy. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"on\"]], \"start\": [[161]], \"entity_id\": [\"T11\"]}, \"Effect\": {\"text\": [[\"renal and ocular blood flow\"]], \"start\": [[107]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"combined hyperglycaemia and hyperinsulinaemia\", \"diabetic patients\"]], \"start\": [[54, 143]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"insulin therapy\"]], \"start\": [[164]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"hyperglycaemia\"], [\"hyperinsulinaemia\"]], \"start\": [[63], [82]], \"entity_id\": [\"T14\", \"T15\"]}, \"Disorder\": {\"text\": [[\"diabetic\"]], \"start\": [[143]], \"entity_id\": [\"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"combined\"]], \"start\": [[54]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"hyperglycaemia\"], [\"hyperinsulinaemia\"]], \"start\": [[63], [82]], \"entity_id\": [\"T14\", \"T15\"]}}]}, \"Negated\": {\"text\": [[\"no data\"]], \"start\": [[29]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
8445549_2 | Pemphigus vulgaris precipitated by glibenclamide therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"precipitated\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Pemphigus vulgaris\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"glibenclamide\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"glibenclamide\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
3804181_1 | Methimazole-associated cholestatic liver injury: case report and brief literature review. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[12]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Methimazole\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Methimazole\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"cholestatic liver injury\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
2452936_2 | The most likely cause of such hyponatremic episode is vinblastine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"is\"]], \"start\": [[51]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"vinblastine\"]], \"start\": [[54]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"vinblastine\"]], \"start\": [[54]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"hyponatremic episode\"]], \"start\": [[30]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"most likely\"]], \"start\": [[4]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
15770343_1 | Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[113]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"optic neuritis secondary\"]], \"start\": [[88]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ethambutol\"]], \"start\": [[116]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ethambutol\"]], \"start\": [[116]], \"entity_id\": [\"T3\"]}}}"
}
]
}
] |
21751692_5 | Based on this experience, we suggest that low-dose ketamine added to propofol may be associated with prevention of EA in children with a history of EA with propofol TIVA. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"prevention\"]], \"start\": [[101]], \"entity_id\": [\"T12\"]}, \"Subject\": {\"text\": [[\"children with a history of EA with propofol TIVA\"]], \"start\": [[121]], \"entity_id\": [\"T10\"], \"Disorder\": {\"text\": [[\"EA with propofol TIVA\"]], \"start\": [[148]], \"entity_id\": [\"T14\"]}, \"Age\": {\"text\": [[\"children\"]], \"start\": [[121]], \"entity_id\": [\"T15\"]}}, \"Treatment\": {\"text\": [[\"low-dose ketamine added to propofol\"]], \"start\": [[42]], \"entity_id\": [\"T13\"], \"Disorder\": {\"text\": [[\"EA\"]], \"start\": [[115]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"ketamine\"], [\"propofol\"]], \"start\": [[51], [69]], \"entity_id\": [\"T18\", \"T19\"]}, \"Dosage\": {\"text\": [[\"low-dose\"]], \"start\": [[42]], \"entity_id\": [\"T20\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"added\"]], \"start\": [[60]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"ketamine\"], [\"propofol\"]], \"start\": [[51], [69]], \"entity_id\": [\"T18\", \"T19\"]}}]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[78]], \"entity_id\": [\"T16\"], \"value\": true}}"
}
]
}
] |
8903300_2 | Tetany in a child with AIDS receiving intravenous tobramycin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[7]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Tetany\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a child with AIDS\"]], \"start\": [[10]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"child\"]], \"start\": [[12]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"AIDS\"]], \"start\": [[23]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"intravenous tobramycin\"]], \"start\": [[38]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"tobramycin\"]], \"start\": [[50]], \"entity_id\": [\"T9\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[38]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
15454180_3 | Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[21]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Sideroblastic anemia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"linezolid\"]], \"start\": [[28]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"linezolid\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"left ventricular assist device\"]], \"start\": [[58]], \"entity_id\": [\"T9\"]}}, \"Subject\": {\"text\": [[\"patient with a left ventricular assist device\"]], \"start\": [[43]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
17655376_2 | Oral dapsone has been available for over 60 years and has been used to treat severe acne vulgaris; however, the oral formulation is known to cause dose-dependent haematological reactions and is currently indicated only for diseases such as dermatitis herpetiformis and Hansen's disease. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[141]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"Oral dapsone\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"dapsone\"]], \"start\": [[5]], \"entity_id\": [\"T13\"]}, \"Route\": {\"text\": [[\"Oral\"]], \"start\": [[0]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"dermatitis herpetiformis\"], [\"Hansen's disease\"]], \"start\": [[240], [269]], \"entity_id\": [\"T15\", \"T16\"]}}, \"Effect\": {\"text\": [[\"dose-dependent haematological reactions\"]], \"start\": [[147]], \"entity_id\": [\"T11\"]}}"
}
]
}
] |
1580986_1 | Enalapril-induced anemia in two kidney transplant recipients. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Enalapril\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Enalapril\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"kidney transplant\"]], \"start\": [[32]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"two kidney transplant recipients\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"anemia\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
10458196_5 | PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulted\"]], \"start\": [[58]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"topical brimonidine\"]], \"start\": [[38]], \"entity_id\": [\"T3\"], \"Route\": {\"text\": [[\"topical\"]], \"start\": [[38]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"brimonidine\"]], \"start\": [[46]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"apparent central nervous system depression and unresponsiveness\"]], \"start\": [[70]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"an infant\"]], \"start\": [[137]], \"entity_id\": [\"T5\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[140]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
16225183_2 | BACKGROUND: Interferon beta has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS). | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"standard therapy\"]], \"start\": [[39]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"Interferon beta\"]], \"start\": [[12]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Interferon beta\"]], \"start\": [[12]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"relapsing/remitting Multiple Sclerosis\"]], \"start\": [[90]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
14566215_1 | In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"implicated\"]], \"start\": [[140]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[234]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[234]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"Epstein's anomaly\"]], \"start\": [[154]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
21751542_5 | The risk of gastrointestinal bleeding during the treatment with antiagregants and anticoagulants, the risk of bradycardia in beta-blockade, possible interactions with other medications lowering the heart rate are discussed. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[38]], \"entity_id\": [\"T11\"]}, \"Effect\": {\"text\": [[\"gastrointestinal bleeding\"]], \"start\": [[12]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"antiagregants and anticoagulants\"]], \"start\": [[64]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"antiagregants\"], [\"anticoagulants\"]], \"start\": [[64], [82]], \"entity_id\": [\"T15\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[78]], \"entity_id\": [\"T14\"]}, \"Drug\": {\"text\": [[\"antiagregants\"], [\"anticoagulants\"]], \"start\": [[64], [82]], \"entity_id\": [\"T15\", \"T16\"]}}]}, \"Speculated\": {\"text\": [[\"risk\"]], \"start\": [[4]], \"entity_id\": [\"T17\"], \"value\": true}}"
},
{
"event_id": "E3",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E3\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[122]], \"entity_id\": [\"T20\"]}, \"Effect\": {\"text\": [[\"bradycardia\"]], \"start\": [[110]], \"entity_id\": [\"T19\"]}, \"Treatment\": {\"text\": [[\"beta-blockade\"]], \"start\": [[125]], \"entity_id\": [\"T21\"], \"Drug\": {\"text\": [[\"beta-blockade\"]], \"start\": [[125]], \"entity_id\": [\"T22\"]}}, \"Speculated\": {\"text\": [[\"risk\"]], \"start\": [[102]], \"entity_id\": [\"T18\"], \"value\": true}}"
}
]
}
] |
847572_1 | Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"enhanced\"]], \"start\": [[30]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Hepatotoxicity\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"paracetamol\", \"ingestion of alcohol\"]], \"start\": [[18, 42]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"paracetamol\"], [\"alcohol\"]], \"start\": [[18], [55]], \"entity_id\": [\"T8\", \"T10\"]}, \"Route\": {\"text\": [[\"ingestion\"]], \"start\": [[42]], \"entity_id\": [\"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"enhanced\"]], \"start\": [[30]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"alcohol\"], [\"paracetamol\"]], \"start\": [[55], [18]], \"entity_id\": [\"T10\", \"T8\"]}}]}, \"Subject\": {\"text\": [[\"two cases.\"]], \"start\": [[74]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[74]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
10099659_7 | Cancer patients who are receiving 5-FU treatment and are DPD deficient can develop severe side effects. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"develop\"]], \"start\": [[75]], \"entity_id\": [\"T13\"]}, \"Subject\": {\"text\": [[\"Cancer patients\", \"are DPD deficient\"]], \"start\": [[0, 53]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"DPD deficient\"]], \"start\": [[57]], \"entity_id\": [\"T11\"]}}, \"Treatment\": {\"text\": [[\"receiving 5-FU\"]], \"start\": [[24]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"5-FU\"]], \"start\": [[34]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"Cancer\"]], \"start\": [[0]], \"entity_id\": [\"T18\"]}}, \"Effect\": {\"text\": [[\"severe side effects\"]], \"start\": [[83]], \"entity_id\": [\"T12\"]}, \"Speculated\": {\"text\": [[\"can\"]], \"start\": [[71]], \"entity_id\": [\"T15\"], \"value\": true}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[83]], \"entity_id\": [\"T16\"], \"value\": \"Medium\"}}"
}
]
}
] |
876914_1 | A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[27]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"A patient\", \"his rheumatoid arthritis\"]], \"start\": [[0, 110]], \"entity_id\": [\"T3\"], \"Gender\": {\"text\": [[\"his\"]], \"start\": [[110]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"poorly differentiated sarcoma\"]], \"start\": [[39]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"cyclophosphamide\"]], \"start\": [[75]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"cyclophosphamide\"]], \"start\": [[75]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"rheumatoid arthritis\"]], \"start\": [[114]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
18344734_1 | Photo-onycholysis caused by olanzapine and aripiprazole. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[18]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Photo-onycholysis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"olanzapine and aripiprazole\"]], \"start\": [[28]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"olanzapine\"], [\"aripiprazole\"]], \"start\": [[28], [43]], \"entity_id\": [\"T7\", \"T8\"]}}}"
}
]
}
] |
7606071_7 | We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"precipitating\"]], \"start\": [[170]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"high dose-infusion time ratio\", \"cisplatin\"]], \"start\": [[69, 213]], \"entity_id\": [\"T3\"], \"Dosage\": {\"text\": [[\"high dose\"]], \"start\": [[69]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"cisplatin\"]], \"start\": [[213]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"anaphylactoid reactions\"]], \"start\": [[184]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"3 patients\"]], \"start\": [[27]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"3\"]], \"start\": [[27]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
10395123_1 | CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[35]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Fixed drug eruption\"]], \"start\": [[12]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"omeprazole\"]], \"start\": [[101]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"omeprazole\"]], \"start\": [[101]], \"entity_id\": [\"T3\"]}}}"
}
]
}
] |
6460590_1 | One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"association\"]], \"start\": [[114]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"SMON\", \"acrodermatitis enteropathica\"]], \"start\": [[12, 36]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"clioquinol\"]], \"start\": [[149]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"clioquinol\"]], \"start\": [[149]], \"entity_id\": [\"T8\"]}}, \"Speculated\": {\"text\": [[\"a very high frequency\"]], \"start\": [[75]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
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