id
stringlengths 7
11
| context
stringlengths 24
527
| is_mult_event
bool 2
classes | annotations
list |
|---|---|---|---|
8071504_8 | There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[42]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"ocular toxicity\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ethambutol\"]], \"start\": [[47]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ethambutol\"]], \"start\": [[47]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
6329575_1 | k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[36]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"lithium\", \"at therapeutic serum lithium levels\"]], \"start\": [[55, 86]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"k bipolar manic-depressive\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[55]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"k bipolar manic-depressive patient\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"bucco-linguo-masticatory dyskinesia\", \"akathisia\"]], \"start\": [[139, 76]], \"entity_id\": [\"T1\"]}}"
}
]
}
] |
11712064_2 | We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"develop\"]], \"start\": [[78]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[12]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"systemic allergic contact dermatitis to 8-MOP\"]], \"start\": [[32]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"PUVA\"]], \"start\": [[114]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"psoriasis\"]], \"start\": [[133]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"PUVA\"]], \"start\": [[114]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
3677571_8 | Seizures were treated with diazepam. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[14]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"diazepam\"]], \"start\": [[27]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"Seizures\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"diazepam\"]], \"start\": [[27]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
10487084_2 | Paradoxical seizures in phenytoin toxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"seizures\"]], \"start\": [[12]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Paradoxical seizures\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"phenytoin toxicity\"]], \"start\": [[24]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"phenytoin\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
1477441_1 | CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[105]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"fixed drug eruption of the scrotum\"]], \"start\": [[115]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"Two children with attention deficit disorder\"]], \"start\": [[14]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"Two\"]], \"start\": [[14]], \"entity_id\": [\"T5\"]}, \"Age\": {\"text\": [[\"children\"]], \"start\": [[18]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"methylphenidate as a simple drug\"]], \"start\": [[72]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"methylphenidate\"]], \"start\": [[72]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"attention deficit disorder\"]], \"start\": [[32]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
24477376_5 | While the patient was receiving both drugs, platelet aggregation studies revealed less platelet inhibition than would be expected in a patient not taking a concomitant inducer of ticagrelor metabolism. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"revealed\"]], \"start\": [[73]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"less platelet inhibition than would be expected\"]], \"start\": [[82]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[133]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"taking a concomitant inducer of ticagrelor metabolism.\"]], \"start\": [[147]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"ticagrelor\"], [\"inducer of ticagrelor metabolism\"]], \"start\": [[179], [168]], \"entity_id\": [\"T10\", \"T12\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"concomitant\"]], \"start\": [[156]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"inducer of ticagrelor metabolism\"], [\"ticagrelor\"]], \"start\": [[168], [179]], \"entity_id\": [\"T12\", \"T10\"]}}]}}"
}
]
}
] |
17667216_2 | Metformin-associated lactic acidosis precipitated by diarrhea. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[10]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Metformin\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Metformin\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lactic acidosis\"]], \"start\": [[21]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
9846036_6 | To date, only 1 death attributable to risperidone overdose has been reported. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"attributable\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"death\"]], \"start\": [[16]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"risperidone overdose\"]], \"start\": [[38]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"risperidone\"]], \"start\": [[38]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"overdose\"]], \"start\": [[50]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"1\"]], \"start\": [[14]], \"entity_id\": [\"T7\"], \"Population\": {\"text\": [[\"1\"]], \"start\": [[14]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
11712064_1 | Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[37]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"8-methoxypsoralen (8-MOP)\"]], \"start\": [[40]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"8-methoxypsoralen\"]], \"start\": [[40]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Systemic allergic contact dermatitis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
3301251_1 | A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[74]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"a 21-year-old woman\"]], \"start\": [[10]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"21-year-old\"]], \"start\": [[12]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[24]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"mild hepatotoxicity\"]], \"start\": [[48]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"choline magnesium trisalicylate\"]], \"start\": [[84]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"choline magnesium trisalicylate\"]], \"start\": [[84]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
9407188_1 | Early ritonavir-induced maculopapular eruption. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[16]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"ritonavir\"]], \"start\": [[6]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ritonavir\"]], \"start\": [[6]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"maculopapular eruption\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
14632592_4 | In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[115]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"therapeutic doses of colchicine for FMF\"]], \"start\": [[57]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"colchicine\"]], \"start\": [[78]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"FMF\"]], \"start\": [[93]], \"entity_id\": [\"T11\"]}, \"Dosage\": {\"text\": [[\"therapeutic doses\"]], \"start\": [[57]], \"entity_id\": [\"T1\"]}}, \"Subject\": {\"text\": [[\"our patient\", \"his renal and hepatic function were normal\"]], \"start\": [[3, 146]], \"entity_id\": [\"T5\"], \"Gender\": {\"text\": [[\"his\"]], \"start\": [[146]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"myopathy\"]], \"start\": [[124]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
20367573_3 | Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Thrombocytosis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"enoxaparin\"]], \"start\": [[26]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"enoxaparin\"]], \"start\": [[26]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
3493797_1 | A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[135]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"a B-cell lymphoma of the lip\"]], \"start\": [[145]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"4 1/2 years of treatment with razoxane\"]], \"start\": [[184]], \"entity_id\": [\"T6\"], \"Duration\": {\"text\": [[\"following 4 1/2 years\"]], \"start\": [[174]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"razoxane\"]], \"start\": [[214]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs\"]], \"start\": [[34]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
9177620_3 | The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"precipitating\"]], \"start\": [[170]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"overdose of CBZ\"]], \"start\": [[127]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"CBZ\"]], \"start\": [[41]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"acute pancreatitis\"]], \"start\": [[202]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
19904536_3 | In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[48]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[36]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"gallbladder metastatic adenocarcinoma\"]], \"start\": [[93]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[36]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"pulmonary toxicity\"]], \"start\": [[56]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"a patient with gallbladder metastatic adenocarcinoma\"]], \"start\": [[78]], \"entity_id\": [\"T9\"]}, \"Severity\": {\"text\": [[\"fatal\"]], \"start\": [[30]], \"entity_id\": [\"T1\"], \"value\": \"High\"}}"
}
]
}
] |
736591_2 | Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[69]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Progressive interstitial fibrosis with roentgenographic honeycombing\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a psoriatic patient\"]], \"start\": [[94]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"a regimen of methotrexate for 18 years\"]], \"start\": [[130]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[143]], \"entity_id\": [\"T8\"]}, \"Duration\": {\"text\": [[\"18 years\"]], \"start\": [[160]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"psoriatic\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
9512187_2 | In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[32]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"one patient\"]], \"start\": [[16]], \"entity_id\": [\"T9\"], \"Population\": {\"text\": [[\"one\"]], \"start\": [[16]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"gangrene\"]], \"start\": [[42]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"bleomycin and vincristine/vinblastine\"]], \"start\": [[57]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"bleomycin\"], [\"vincristine\"], [\"vinblastine\"]], \"start\": [[57], [71], [83]], \"entity_id\": [\"T14\", \"T15\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[67]], \"entity_id\": [\"T18\"]}, \"Drug\": {\"text\": [[\"bleomycin\"], [\"vincristine\"], [\"vinblastine\"]], \"start\": [[57], [71], [83]], \"entity_id\": [\"T14\", \"T15\", \"T16\"]}}]}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[201]], \"entity_id\": [\"T17\"], \"value\": \"High\"}}"
}
]
}
] |
8438851_4 | These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"lead\"]], \"start\": [[44]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"rhabdomyolysis\"]], \"start\": [[52]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"patients\"]], \"start\": [[84]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"vasopressin\"]], \"start\": [[103]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"vasopressin\"]], \"start\": [[103]], \"entity_id\": [\"T7\"]}, \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[115]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
20412003_3 | Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reaction\"]], \"start\": [[147]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"children\"]], \"start\": [[40]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"children\"]], \"start\": [[40]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"TMP-SMX\"]], \"start\": [[29]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"TMP-SMX\"]], \"start\": [[29]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"life-threatening, immunemediated hypersensitivity\"]], \"start\": [[97]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[85]], \"entity_id\": [\"T5\"], \"value\": true}, \"Severity\": {\"text\": [[\"life-threatening\"]], \"start\": [[97]], \"entity_id\": [\"T10\"], \"value\": \"High\"}}"
}
]
}
] |
19789166_1 | Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"caused\"]], \"start\": [[235]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"toxic liver damage\"]], \"start\": [[216]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"nitrofurantoin\"]], \"start\": [[245]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"nitrofurantoin\"]], \"start\": [[245]], \"entity_id\": [\"T6\"]}}, \"Speculated\": {\"text\": [[\"probably\"]], \"start\": [[195]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
8597009_3 | Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"develop\"]], \"start\": [[90]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"phenytoin\", \"together with antituberculosis\"]], \"start\": [[135, 178]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"antituberculosis\"], [\"phenytoin\"]], \"start\": [[192], [135]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"together\"]], \"start\": [[178]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"phenytoin\"], [\"antituberculosis\"]], \"start\": [[135], [192]], \"entity_id\": [\"T11\", \"T10\"]}}]}, \"Subject\": {\"text\": [[\"Slow acetylators\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"Slow acetylators\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"clinical and biochemical features of phenytoin toxicity\"]], \"start\": [[98]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"likely\"]], \"start\": [[80]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
12235444_3 | Therefore there is the potential for significant concentration-related adverse effects when phenytoin is coadministered with other CYP2C9 substrates. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"potentia\"]], \"start\": [[23]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"significant concentration-related adverse effects\"]], \"start\": [[37]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"phenytoin\", \"other CYP2C9 substrates\"]], \"start\": [[92, 125]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"phenytoin\"], [\"other CYP2C9 substrates\"]], \"start\": [[92], [125]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"coadministered\"]], \"start\": [[105]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"phenytoin\"], [\"other CYP2C9 substrates\"]], \"start\": [[92], [125]], \"entity_id\": [\"T10\", \"T11\"]}}]}}"
}
]
}
] |
9554064_2 | Putaminal infarct in methanol intoxication: case report and role of brain imaging studies. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"intoxication\"]], \"start\": [[30]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"methanol\"]], \"start\": [[21]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methanol\"]], \"start\": [[21]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Putaminal infarct in methanol intoxication\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
736591_3 | Progressive interstitial lung disease from prolonged methotrexate therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"from\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Progressive interstitial lung disease\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"prolonged methotrexate therapy\"]], \"start\": [[43]], \"entity_id\": [\"T4\"], \"Duration\": {\"text\": [[\"prolonged\"]], \"start\": [[43]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[53]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
16044093_2 | The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[126]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"a large dose of intravenous iron sucrose\"]], \"start\": [[43]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"iron sucrose\"]], \"start\": [[71]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"16 mg/kg\"]], \"start\": [[85]], \"entity_id\": [\"T9\"]}, \"Duration\": {\"text\": [[\"3 hours\"]], \"start\": [[100]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"systemic iron toxicity\"]], \"start\": [[148]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a child\"]], \"start\": [[29]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"child\"]], \"start\": [[31]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
11292139_1 | We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[123]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin\"]], \"start\": [[10]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"exposed to subsequent chemotherapy with oxaliplatin\"]], \"start\": [[192]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"advanced colonic carcinoma\"]], \"start\": [[25]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"concomitant chemoirradiation\"], [\"oxaliplatin\"], [\"oxaliplatin\"]], \"start\": [[73], [107], [232]], \"entity_id\": [\"T9\", \"T10\", \"T11\"]}}, \"Effect\": {\"text\": [[\"a peculiar dermnatitis in the irradiated field\"]], \"start\": [[133]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
1751354_2 | Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"trigger\"]], \"start\": [[158]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Recombinant human interferon-alpha\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Recombinant human interferon-alpha\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"cancers\"]], \"start\": [[77]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"exacerbate psoriasis\"]], \"start\": [[134]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[130]], \"entity_id\": [\"T10\"], \"value\": true}}"
}
]
}
] |
17034541_3 | This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurring\"]], \"start\": [[43]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"HBV reactivation\"]], \"start\": [[26]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"the year following rituximab monotherapy in the absence of any other immunosuppressive factor\"]], \"start\": [[60]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"rituximab\"]], \"start\": [[79]], \"entity_id\": [\"T6\"]}, \"Time_elapsed\": {\"text\": [[\"year following\"]], \"start\": [[64]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
6958210_2 | Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[29]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Systemic lupus erythematosus\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"penicillamine therapy\"]], \"start\": [[36]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"penicillamine\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"rheumatoid arthritis.\"]], \"start\": [[62]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
7538828_7 | In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[70]], \"entity_id\": [\"T14\"]}, \"Effect\": {\"text\": [[\"dermatologic toxicity\", \"an 'allergic' or acute hypersensitivity reaction\"]], \"start\": [[48, 119]], \"entity_id\": [\"T13\"]}, \"Treatment\": {\"text\": [[\"a single low dose of the drug\", \"MTX\"]], \"start\": [[80, 171]], \"entity_id\": [\"T15\"], \"Drug\": {\"text\": [[\"MTX\"]], \"start\": [[171]], \"entity_id\": [\"T17\"]}, \"Dosage\": {\"text\": [[\"single low dose\"]], \"start\": [[82]], \"entity_id\": [\"T19\"]}}, \"Subject\": {\"text\": [[\"this patient\"]], \"start\": [[178]], \"entity_id\": [\"T16\"]}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[41]], \"entity_id\": [\"T20\"], \"value\": \"High\"}}"
}
]
}
] |
3346128_2 | Erosion of psoriatic plaques after chronic methotrexate administration. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[29]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Erosion of psoriatic plaques\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\": [[43]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[43]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
3982906_1 | Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"infants with supraventricular tachycardia\"]], \"start\": [[54]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"infants\"]], \"start\": [[54]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Cardiac decompensation\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"verapamil therapy\"]], \"start\": [[33]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"supraventricular tachycardia\"]], \"start\": [[67]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"verapamil\"]], \"start\": [[33]], \"entity_id\": [\"T1\"]}}}"
}
]
}
] |
19183077_3 | We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[39]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"tenofovir (TDF)\"]], \"start\": [[23]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"tenofovir\"]], \"start\": [[23]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"HIV\"]], \"start\": [[80]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"nephrotoxicity\"]], \"start\": [[50]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"perinatally HIV-infected adolescents\"]], \"start\": [[68]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"adolescents\"]], \"start\": [[93]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
12324937_6 | RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[71]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[59]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[59]], \"entity_id\": [\"T3\"]}}, \"Effect\": {\"text\": [[\"HUS\"]], \"start\": [[82]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
17260498_5 | Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[106]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"docetaxel\"]], \"start\": [[96]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"docetaxel\"]], \"start\": [[96]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"pulmonary toxicity\", \"respiratory symptoms\"]], \"start\": [[114, 218]], \"entity_id\": [\"T8\"]}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[89]], \"entity_id\": [\"T11\"], \"value\": \"Medium\"}}"
}
]
}
] |
22791547_3 | In this article, the authors report a 7-year-old male patient who presented with orofacial and limb dyskinesia after his first dose of methylphenidate treatment for a diagnosis of attention-deficit/hyperactivity disorder; he was also receiving sodium valproate treatment for epilepsy. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[111]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"a 7-year-old male patient\"]], \"start\": [[36]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"7-year-old\"]], \"start\": [[38]], \"entity_id\": [\"T14\"]}, \"Gender\": {\"text\": [[\"male\"]], \"start\": [[49]], \"entity_id\": [\"T15\"]}}, \"Effect\": {\"text\": [[\"orofacial and limb dyskinesia\"]], \"start\": [[81]], \"entity_id\": [\"T13\"]}, \"Treatment\": {\"text\": [[\"first dose of methylphenidate\"]], \"start\": [[121]], \"entity_id\": [\"T11\"], \"Disorder\": {\"text\": [[\"attention-deficit/hyperactivity disorder\"]], \"start\": [[180]], \"entity_id\": [\"T12\"]}, \"Time_elapsed\": {\"text\": [[\"first dose\"]], \"start\": [[121]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"methylphenidate\"]], \"start\": [[135]], \"entity_id\": [\"T17\"]}}}"
},
{
"event_id": "E2",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[234]], \"entity_id\": [\"T22\"]}, \"Subject\": {\"text\": [[\"a 7-year-old male patient\"]], \"start\": [[36]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"7-year-old\"]], \"start\": [[38]], \"entity_id\": [\"T14\"]}, \"Gender\": {\"text\": [[\"male\"]], \"start\": [[49]], \"entity_id\": [\"T15\"]}}, \"Treatment\": {\"text\": [[\"sodium valproate\"]], \"start\": [[244]], \"entity_id\": [\"T20\"], \"Disorder\": {\"text\": [[\"epilepsy\"]], \"start\": [[275]], \"entity_id\": [\"T19\"]}, \"Drug\": {\"text\": [[\"sodium valproate\"]], \"start\": [[244]], \"entity_id\": [\"T21\"]}}}"
}
]
}
] |
12221670_1 | The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[46]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"70-year-old man\"]], \"start\": [[26]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"70-year-old\"]], \"start\": [[26]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[38]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"severe aplastic anemia\"]], \"start\": [[56]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"7 weeks after treatment with 500 mg of ticlopidine daily\"]], \"start\": [[79]], \"entity_id\": [\"T5\"], \"Time_elapsed\": {\"text\": [[\"7 weeks\"]], \"start\": [[79]], \"entity_id\": [\"T10\"]}, \"Dosage\": {\"text\": [[\"500 mg\"]], \"start\": [[108]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"ticlopidine\"]], \"start\": [[118]], \"entity_id\": [\"T12\"]}, \"Freq\": {\"text\": [[\"daily\"]], \"start\": [[130]], \"entity_id\": [\"T13\"]}}}"
}
]
}
] |
17931455_1 | CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[77]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"A six-year-old boy with transfusion-dependent beta-thalassaemia\"]], \"start\": [[13]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"six-year-old\"]], \"start\": [[15]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"a unilateral hearing loss\"]], \"start\": [[87]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"commencing desferrioxamine therapy\"]], \"start\": [[127]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"transfusion-dependent beta-thalassaemia\"]], \"start\": [[37]], \"entity_id\": [\"T9\"]}, \"Time_elapsed\": {\"text\": [[\"shortly after\"]], \"start\": [[113]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"desferrioxamine\"]], \"start\": [[138]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
9796135_4 | Syncope in a 65-year-old woman after nitrate ingestion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[31]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Syncope\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a 65-year-old woman\"]], \"start\": [[11]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"65-year-old\"]], \"start\": [[13]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[25]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"nitrate ingestion\"]], \"start\": [[37]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"nitrate\"]], \"start\": [[37]], \"entity_id\": [\"T9\"]}, \"Route\": {\"text\": [[\"ingestion\"]], \"start\": [[45]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
18691992_3 | Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"appeared\"]], \"start\": [[71]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"longitudinal melanonychia and the multiple skin cancers\"]], \"start\": [[9]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"approximately 6 months of hydroxyurea treatment\"]], \"start\": [[86]], \"entity_id\": [\"T7\"], \"Duration\": {\"text\": [[\"6 months\"]], \"start\": [[100]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"hydroxyurea\"]], \"start\": [[112]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
7854541_2 | Multifocal inflammatory leukoencephalopathy associated with levamisole therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated with\"]], \"start\": [[44]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Multifocal inflammatory leukoencephalopathy\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"levamisole therapy\"]], \"start\": [[60]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"levamisole\"]], \"start\": [[60]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
9247841_5 | The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"cutaneous vasculitis\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"propylthiouracil\"]], \"start\": [[65]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"propylthiouracil\"]], \"start\": [[65]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
16109609_3 | Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[73]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[61]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[61]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"radiation recall reaction resulting in hemodynamically significant pericardial effusion\"]], \"start\": [[81]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
18648015_3 | OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[43]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"cefazolin\"]], \"start\": [[33]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"cefazolin\"]], \"start\": [[33]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"leukopenia\"]], \"start\": [[51]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a critically ill patient\"]], \"start\": [[65]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"critically ill\"]], \"start\": [[67]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
6149250_4 | The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"controlled\"]], \"start\": [[64]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"The second patient suffered from high blood pressure\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"beta-blocker drugs\"]], \"start\": [[80]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"high blood pressure\"]], \"start\": [[33]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"beta-blocker drugs\"]], \"start\": [[80]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
11999915_3 | The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[71]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"The female patient\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Gender\": {\"text\": [[\"female\"]], \"start\": [[4]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"agranulocytosis\"]], \"start\": [[79]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"clozapine in a daily dose of 400 mg\", \"after 2 months\"]], \"start\": [[28, 95]], \"entity_id\": [\"T6\"], \"Duration\": {\"text\": [[\"2 months\"]], \"start\": [[101]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"400 mg\"]], \"start\": [[57]], \"entity_id\": [\"T9\"]}, \"Freq\": {\"text\": [[\"daily\"]], \"start\": [[43]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"clozapine\"]], \"start\": [[28]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
11399735_4 | We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[99]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"interstitial pulmonary disease\", \"lymphocytic colitis\"]], \"start\": [[20, 79]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"ticlopidine\"]], \"start\": [[121]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"ticlopidine\"]], \"start\": [[121]], \"entity_id\": [\"T8\"]}}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[10]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
9579301_1 | Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[26]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"venlafaxine\"]], \"start\": [[82]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"venlafaxine\"]], \"start\": [[82]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"Increased ocular pressure\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"two patients with narrow angle glaucoma\"]], \"start\": [[29]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"narrow angle glaucoma\"]], \"start\": [[47]], \"entity_id\": [\"T4\"]}, \"Population\": {\"text\": [[\"two\"]], \"start\": [[29]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
6484655_1 | Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[203]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"seizures\"]], \"start\": [[189]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ampicillin therapy\"]], \"start\": [[218]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"ampicillin\"]], \"start\": [[218]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
2250853_1 | Glaucoma secondary to epithelial downgrowth and 5-fluorouracil. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"secondary\"]], \"start\": [[9]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Glaucoma\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[48]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"5-fluorouracil\"]], \"start\": [[48]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
17319250_1 | Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"at\"]], \"start\": [[77]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"fluctuation of the QT interval\"]], \"start\": [[46]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"this patient\"]], \"start\": [[26]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"a stable dose of methadone\"]], \"start\": [[80]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"methadone\"]], \"start\": [[97]], \"entity_id\": [\"T7\"]}, \"Dosage\": {\"text\": [[\"a stable dose\"]], \"start\": [[80]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
20190474_4 | This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[66]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"zonisamide\"]], \"start\": [[55]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"zonisamide\"]], \"start\": [[55]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"acute kidney injury due to\", \"DRESS/DIHS\"]], \"start\": [[28, 74]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
1393348_2 | Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"considered\"]], \"start\": [[135]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"SLE\"]], \"start\": [[122]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"carbamazepine\"]], \"start\": [[170]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"carbamazepine\"]], \"start\": [[170]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"could\"]], \"start\": [[126]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
10803790_1 | BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induce\"]], \"start\": [[75]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"various degrees of hepatic lesion with ground-glass inclusion bodies\"]], \"start\": [[82]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Cyanamide\"]], \"start\": [[12]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Cyanamide\"]], \"start\": [[12]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
17675030_3 | Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[14]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Oxcarbazepine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Oxcarbazepine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both)\"]], \"start\": [[25]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
16432996_5 | The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"given\"]], \"start\": [[62]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha\"]], \"start\": [[71]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"50-year-old\"]], \"start\": [[73]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"female\"]], \"start\": [[85]], \"entity_id\": [\"T12\"]}}, \"Treatment\": {\"text\": [[\"combination therapy of interferon alpha and ribavirin\"]], \"start\": [[4]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"CHC\"]], \"start\": [[97]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"interferon alpha\"], [\"ribavirin\"]], \"start\": [[27], [48]], \"entity_id\": [\"T15\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"combination\"]], \"start\": [[4]], \"entity_id\": [\"T14\"]}, \"Drug\": {\"text\": [[\"interferon alpha\"], [\"ribavirin\"]], \"start\": [[27], [48]], \"entity_id\": [\"T15\", \"T16\"]}}]}}"
}
]
}
] |
15494638_1 | Peripheral neuropathy associated with capecitabine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Peripheral neuropathy\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"capecitabine.\"]], \"start\": [[38]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"capecitabine\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
16411025_1 | DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"intrathecal\"]], \"start\": [[181]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"MTX\"]], \"start\": [[193]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"MTX\"]], \"start\": [[193]], \"entity_id\": [\"T8\"]}, \"Time_elapsed\": {\"text\": [[\"within days\"]], \"start\": [[166]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"a central neurological syndrome\"]], \"start\": [[134]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"medical records of four patients\"]], \"start\": [[24]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"four\"]], \"start\": [[43]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
9497597_1 | Prothipendylhydrochloride-induced priapism: case report. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Prothipendylhydrochloride\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Prothipendylhydrochloride\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"priapism\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
19897274_2 | Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[32]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"sorafenib treatment:\"]], \"start\": [[48]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"sorafenib\"]], \"start\": [[48]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"Interstitial pneumonia\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"probably\"]], \"start\": [[23]], \"entity_id\": [\"T6\"], \"value\": true}}"
}
]
}
] |
19915794_1 | He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[34]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"hypokalemia (K 2.3 mmol/L)\"]], \"start\": [[7]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy\"]], \"start\": [[45]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"licorice\"], [\"disopyramide\"], [\"bicalutamide\"], [\"silodosin\"]], \"start\": [[45], [76], [105], [143]], \"entity_id\": [\"T6\", \"T7\", \"T8\", \"T9\"]}, \"Disorder\": {\"text\": [[\"prostate hypertrophy\"], [\"prostate cancer\"], [\"arrhythmia\"]], \"start\": [[157], [122], [93]], \"entity_id\": [\"T10\", \"T11\", \"T12\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[54]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"disopyramide\"], [\"bicalutamide\"], [\"silodosin\"], [\"licorice\"]], \"start\": [[76], [105], [143], [45]], \"entity_id\": [\"T7\", \"T8\", \"T9\", \"T6\"]}}]}}"
}
]
}
] |
20412003_5 | Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[128]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"TMP-SMX therapy\"]], \"start\": [[166]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"TMP-SMX\"]], \"start\": [[166]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"hepatotoxicity\"]], \"start\": [[143]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patient's\"]], \"start\": [[118]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"probable\"]], \"start\": [[71]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
24429012_9 | Since its introduction in 2012, vismodegib has been implicated as a possible factor in seven reports of patient deaths. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"implicated\"]], \"start\": [[52]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"vismodegib\"]], \"start\": [[32]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"vismodegib\"]], \"start\": [[32]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"deaths\"]], \"start\": [[112]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"seven reports of patient\"]], \"start\": [[87]], \"entity_id\": [\"T9\"], \"Population\": {\"text\": [[\"seven\"]], \"start\": [[87]], \"entity_id\": [\"T10\"]}}, \"Speculated\": {\"text\": [[\"possible\"]], \"start\": [[68]], \"entity_id\": [\"T12\"], \"value\": true}}"
}
]
}
] |
8461228_2 | Acceleration of ventricular response to atrial flutter after intravenous adenosine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[55]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"intravenous adenosine.\"]], \"start\": [[61]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"adenosine\"]], \"start\": [[73]], \"entity_id\": [\"T6\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[61]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"atrial flutter\"]], \"start\": [[40]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"Acceleration of ventricular response\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
15331204_1 | Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induction\"]], \"start\": [[9]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"diabetes\"]], \"start\": [[22]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"indapamide\"]], \"start\": [[65]], \"entity_id\": [\"T10\"], \"Disorder\": {\"text\": [[\"hypertension\"]], \"start\": [[47]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"indapamide\"]], \"start\": [[65]], \"entity_id\": [\"T12\"]}}, \"Speculated\": {\"text\": [[\"Possible\"]], \"start\": [[0]], \"entity_id\": [\"T11\"], \"value\": true}}"
}
]
}
] |
4036917_1 | Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[52]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"RS\"]], \"start\": [[67]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"children\"]], \"start\": [[76]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"children\"]], \"start\": [[76]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"long-term aspirin therapy\"]], \"start\": [[103]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"systemic inflammatory illnesses\"]], \"start\": [[150]], \"entity_id\": [\"T5\"]}, \"Drug\": {\"text\": [[\"aspirin\"]], \"start\": [[113]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"potential\"]], \"start\": [[34]], \"entity_id\": [\"T10\"], \"value\": true}}"
}
]
}
] |
889156_7 | While a lower systemic steroid dosage may have been the provoking factor, we feel that an adverse reaction to oleic acid, a dispersing agent in the aerosol freon vehicle, is a strong possibility. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[107]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"oleic acid\"]], \"start\": [[110]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"oleic acid\"]], \"start\": [[110]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"adverse reaction\"]], \"start\": [[90]], \"entity_id\": [\"T7\"]}, \"Speculated\": {\"text\": [[\"strong possibility\"]], \"start\": [[176]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
16119501_2 | Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"resulting\"]], \"start\": [[29]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Baclofen withdrawal syndrome\", \"prolonged fever in the intensive care unit\"]], \"start\": [[0, 119]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"underdosing of oral baclofen\"]], \"start\": [[44]], \"entity_id\": [\"T5\"], \"Route\": {\"text\": [[\"oral\"]], \"start\": [[59]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"baclofen\"]], \"start\": [[64]], \"entity_id\": [\"T10\"]}}, \"Speculated\": {\"text\": [[\"potential source\"]], \"start\": [[99]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
7787496_2 | We present a case of sotalol-induced bradycardia reversed by glucagon. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[29]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"sotalol\"]], \"start\": [[21]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"sotalol\"]], \"start\": [[21]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"bradycardia\"]], \"start\": [[37]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[11]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
8192712_2 | Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[39]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Hyperammonemia\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"valproic acid therapy\"]], \"start\": [[55]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"valproic acid\"]], \"start\": [[55]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
19423610_7 | Methylene blue has been found to be a potent inhibitor of monoamine oxidase (MAO), and several cases of serotonin toxicity have been reported recently following its administration. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[151]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"Methylene blue\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Methylene blue\"]], \"start\": [[0]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"serotonin toxicity\"]], \"start\": [[104]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"several cases\"]], \"start\": [[87]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
8903300_1 | She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"had\"]], \"start\": [[87]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"a 3-week course of intravenous tobramycin\"]], \"start\": [[22]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"tobramycin\"]], \"start\": [[53]], \"entity_id\": [\"T7\"]}, \"Duration\": {\"text\": [[\"3-week course\"]], \"start\": [[24]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[41]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"bronchiectasis\"]], \"start\": [[68]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"elevated serum tobramycin trough level 1 week before the onset of tetany\"]], \"start\": [[94]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
9796135_3 | In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[29]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"administration of isosorbide dinitrate (5 mg)\"]], \"start\": [[35]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"isosorbide dinitrate\"]], \"start\": [[53]], \"entity_id\": [\"T12\"]}, \"Dosage\": {\"text\": [[\"5 mg\"]], \"start\": [[75]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"blood pressure decreased\"], [\"syncope\"], [\"a sudden decrease in pulse rate\"]], \"start\": [[82], [146], [159]], \"entity_id\": [\"T8\", \"T9\", \"T10\"]}}"
}
]
}
] |
19122478_7 | The condition improved slowly after stopping medication and systemic steroids. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"stopping\"]], \"start\": [[36]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"steroids\"]], \"start\": [[69]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"steroids\"]], \"start\": [[69]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"condition improved\"]], \"start\": [[4]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
19995690_2 | Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[50]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"Acetaminophen\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Acetaminophen\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"acute liver failure\"]], \"start\": [[56]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
10203437_9 | Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"experience\"]], \"start\": [[42]], \"entity_id\": [\"T11\"]}, \"Subject\": {\"text\": [[\"Patients\", \"who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease\"]], \"start\": [[0, 38]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"5-ASA compounds\"]], \"start\": [[22]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"5-ASA\"]], \"start\": [[22]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"gastrointestinal disease\"]], \"start\": [[128]], \"entity_id\": [\"T15\"]}}, \"Effect\": {\"text\": [[\"lupus-like reaction\"]], \"start\": [[186]], \"entity_id\": [\"T16\"]}, \"Speculated\": {\"text\": [[\"rule out\"]], \"start\": [[175]], \"entity_id\": [\"T13\"], \"value\": true}}"
}
]
}
] |
10466445_1 | Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[11]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a patient with ATRA-resistant relapse of acute promyelocytic leukemia\"]], \"start\": [[46]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"arsenic trioxide\"]], \"start\": [[26]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"arsenic trioxide\"]], \"start\": [[26]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"ATRA-resistant relapse of acute promyelocytic leukemia\"]], \"start\": [[61]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
19122478_1 | Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[50]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Drug rash with eosinophilia and systemic symptoms\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"chlorambucil\"]], \"start\": [[56]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"chlorambucil\"]], \"start\": [[56]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"chronic lymphocytic leukaemia\"]], \"start\": [[82]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
1688693_3 | She manifested all the clinical symptoms and signs of caffeine toxicity. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"manifested\"]], \"start\": [[4]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Gender\": {\"text\": [[\"She\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}}, \"Treatment\": {\"text\": [[\"caffeine\"]], \"start\": [[54]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"caffeine\"]], \"start\": [[54]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"all the clinical symptoms and signs of caffeine toxicity.\"]], \"start\": [[15]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
2406680_1 | Quinine-induced hearing loss. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[8]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Quinine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Quinine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"hearing loss\"]], \"start\": [[16]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
17458405_1 | Ezetimibe-induced acute pancreatitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Ezetimibe\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Ezetimibe\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"acute pancreatitis\"]], \"start\": [[18]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
1569260_2 | We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[25]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"pemphigus\"]], \"start\": [[33]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"captopril\"]], \"start\": [[97]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"captopril\"]], \"start\": [[97]], \"entity_id\": [\"T7\"]}}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[10]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
10589077_5 | We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"therapy\"]], \"start\": [[29]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"in patients with thalassemia intermedia\"]], \"start\": [[37]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"low-dose HU therapy\"]], \"start\": [[17]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"thalassemia intermedia\"]], \"start\": [[54]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"HU\"]], \"start\": [[26]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"low-dose\"]], \"start\": [[17]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"increase total Hb levels\"]], \"start\": [[81]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[77]], \"entity_id\": [\"T10\"], \"value\": true}}"
}
]
}
] |
1115340_6 | There is the risk of convulsions occurring in susceptible patients following the use of the new anaesthetic agents which are capable of inducing CNS excitability. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurring\"]], \"start\": [[33]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"convulsions\"]], \"start\": [[21]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"susceptible patients\"]], \"start\": [[46]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"the use of the new anaesthetic agents which are capable of inducing CNS excitability\"]], \"start\": [[77]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"anaesthetic\"]], \"start\": [[96]], \"entity_id\": [\"T1\"]}}}"
}
]
}
] |
984862_1 | A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[141]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"postprandial hyperglycemia and glycosuria\"]], \"start\": [[151]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion\"]], \"start\": [[200]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"psoriasis\"]], \"start\": [[15]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"halcinonide\"]], \"start\": [[262]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"cream\"]], \"start\": [[274]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"an abnormal response to the glucose tolerance test without other evidence of diabetes\"]], \"start\": [[46]], \"entity_id\": [\"T1\"]}}}"
}
]
}
] |
8503421_1 | Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[229]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"t-PA therapy\"]], \"start\": [[239]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"t-PA\"]], \"start\": [[239]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"atheroembolic acute renal failure\"]], \"start\": [[195]], \"entity_id\": [\"T8\"]}}"
},
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[70]], \"entity_id\": [\"T16\"]}, \"Treatment\": {\"text\": [[\"t-PA\"]], \"start\": [[80]], \"entity_id\": [\"T15\"], \"Drug\": {\"text\": [[\"t-PA\"]], \"start\": [[80]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"cholesterol crystal embolization\", \"with only extrarenal manifestations\"]], \"start\": [[37, 93]], \"entity_id\": [\"T13\"]}}"
}
]
}
] |
573779_3 | A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[14]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A young woman\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"young\"]], \"start\": [[2]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[8]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"galactorrhea\"]], \"start\": [[24]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"during treatment with a new dibenzoxazepine antidepressant, amoxapine\"]], \"start\": [[37]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"amoxapine\"]], \"start\": [[97]], \"entity_id\": [\"T13\"]}}}"
}
]
}
] |
7379406_7 | After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"linked to\"]], \"start\": [[81]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"fluorosis\"]], \"start\": [[67]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"the patient's\"]], \"start\": [[53]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"chronic use of niflumic acid\"]], \"start\": [[91]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"niflumic acid\"]], \"start\": [[106]], \"entity_id\": [\"T10\"]}, \"Duration\": {\"text\": [[\"chronic\"]], \"start\": [[91]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
20203465_2 | The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[124]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"acute renal failure\"]], \"start\": [[104]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"IVIG\"]], \"start\": [[130]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"IVIG\"]], \"start\": [[130]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
18504683_3 | We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[109]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"3 cases of children with acute lymphoblastic leukemia\"]], \"start\": [[10]], \"entity_id\": [\"T5\"], \"Population\": {\"text\": [[\"3\"]], \"start\": [[10]], \"entity_id\": [\"T9\"]}, \"Age\": {\"text\": [[\"children\"]], \"start\": [[21]], \"entity_id\": [\"T1\"]}}, \"Effect\": {\"text\": [[\"seizures and altered sensorium\"]], \"start\": [[78]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"L-asparaginase\"]], \"start\": [[115]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"acute lymphoblastic leukemia\"]], \"start\": [[35]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"L-asparaginase\"]], \"start\": [[115]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
8921647_2 | Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[45]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"tolazoline\"]], \"start\": [[34]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"tolazoline\"]], \"start\": [[34]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"upper gastrointestinal bleeding\"]], \"start\": [[53]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
10749332_3 | Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"provide\"]], \"start\": [[69]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"thiazolidinediones\"]], \"start\": [[6]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"thiazolidinediones\"]], \"start\": [[6]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
15840734_2 | OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[68]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"a case of neuroleptic malignant syndrome (NMS)\"]], \"start\": [[21]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"fluphenazine\"]], \"start\": [[84]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"schizophrenic\"]], \"start\": [[102]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"fluphenazine\"]], \"start\": [[84]], \"entity_id\": [\"T12\"]}}, \"Subject\": {\"text\": [[\"schizophrenic patient\"]], \"start\": [[102]], \"entity_id\": [\"T10\"]}}"
}
]
}
] |
9876812_2 | CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"responsible\"]], \"start\": [[110]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"vinorelbine\"]], \"start\": [[80]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"vinorelbine\"]], \"start\": [[80]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"SIADH\"]], \"start\": [[126]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
2940999_1 | Abnormal retinal function associated with isotretinoin therapy for acne. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[26]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"Abnormal retinal function\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"isotretinoin\"]], \"start\": [[42]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"acne\"]], \"start\": [[67]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"isotretinoin\"]], \"start\": [[42]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
2299784_3 | To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[75]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"first reported case\"]], \"start\": [[31]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"first\"]], \"start\": [[31]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"bromide intoxication\"]], \"start\": [[54]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"pyridostigmine bromide\"]], \"start\": [[82]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"pyridostigmine bromide\"]], \"start\": [[82]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
15920338_3 | In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated with\"]], \"start\": [[95]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"tamoxifen\"]], \"start\": [[111]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"x\"], [\"tamoxifen\"], [\"tamoxifen\"]], \"start\": [[19], [111], [15]], \"entity_id\": [\"T10\", \"T11\", \"T12\"]}}, \"Effect\": {\"text\": [[\"potentially life-threatening adverse events\", \"including endometrial adenocarcinoma or uterine sarcoma\"]], \"start\": [[51, 143]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
8891729_4 | We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[141]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a patient with chronic lymphocytic leukemia (CLL)\"]], \"start\": [[22]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"fatal intravascular autoimmune hemolytic anemia (AIHA)\"]], \"start\": [[86]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"fludarabine treatment\"]], \"start\": [[147]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"fludarabine\"]], \"start\": [[147]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"chronic lymphocytic leukemia\"]], \"start\": [[37]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
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