This is a medical question of type : symptoms 
 What are the symptoms of Tumor necrosis factor receptor-associated periodic syndrome ? 
 What are the signs and symptoms of Tumor necrosis factor receptor-associated periodic syndrome? The characteristic feature of TRAPS is recurrent episodes of fever. Episodes may begin at any age, but most often begin in early childhood. Fevers usually last around 3 weeks but can last from days to months. The time between episodes can vary considerably from weeks to years. Fevers are often associated with other symptoms, which may include muscle, joint, and/or abdominal pain; a spreading rash; puffiness and/or swelling around the eyes; and/or inflammation in various other areas of the body including the heart muscle, joints, throat, or mucous membranes. About 25% of people with TRAPS develop amyloidosis, which can lead to kidney or liver failure. The Human Phenotype Ontology provides the following list of signs and symptoms for Tumor necrosis factor receptor-associated periodic syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Erysipelas 90% Hypermelanotic macule 90% Skin rash 90% Abdominal pain 50% Abnormality of the pericardium 50% Abnormality of the pleura 50% Arthralgia 50% Arthritis 50% Chest pain 50% Constipation 50% Intestinal obstruction 50% Leukocytosis 50% Myalgia 50% Nausea and vomiting 50% Orchitis 50% Periorbital edema 50% Abnormality of the myocardium 7.5% Abnormality of the oral cavity 7.5% Abnormality of the sacroiliac joint 7.5% Alopecia 7.5% Behavioral abnormality 7.5% Bruising susceptibility 7.5% Cellulitis 7.5% Coronary artery disease 7.5% Cranial nerve paralysis 7.5% Diarrhea 7.5% Elevated hepatic transaminases 7.5% Fasciitis 7.5% Hepatomegaly 7.5% Inflammatory abnormality of the eye 7.5% Migraine 7.5% Myositis 7.5% Nephropathy 7.5% Paresthesia 7.5% Peritonitis 7.5% Recurrent pharyngitis 7.5% Splenomegaly 7.5% Vasculitis 7.5% Vertigo 7.5% Visual impairment 7.5% Amyloidosis - Autosomal dominant inheritance - Edema - Elevated erythrocyte sedimentation rate - Episodic fever - Hepatic amyloidosis - Muscle stiffness - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.