This is a medical question of type : symptoms 
 What are the symptoms of Sickle Cell Disease ? 
 Early Signs and Symptoms
                
If a person has sickle cell disease (SCD), it is present at birth. But most infants do not have any problems from the disease until they are about 5 or 6 months of age. Every state in the United States, the District of Columbia, and the U.S. territories requires that all newborn babies receive screening for SCD. When a child has SCD, parents are notified before the child has symptoms.
                
Some children with SCD will start to have problems early on, and some later. Early symptoms of SCD may include:
                
Painful swelling of the hands and feet, known as dactylitis
                
Fatigue or fussiness from anemia
                
A yellowish color of the skin, known as jaundice, or whites of the eyes, known as icteris, that occurs when a large number of red cells hemolyze
                
The signs and symptoms of SCD will vary from person to person and can change over time. Most of the signs and symptoms of SCD are related to complications of the disease.
                
Major Complications of Sickle Cell Disease
                
Acute Pain (Sickle Cell or Vaso-occlusive) Crisis
                
Pain episodes (crises) can occur without warning when sickle cells block blood flow and decrease oxygen delivery. People describe this pain as sharp, intense, stabbing, or throbbing. Severe crises can be even more uncomfortable than post-surgical pain or childbirth.
                
Pain can strike almost anywhere in the body and in more than one spot at a time. But the pain often occurs in the
                
Lower back
                
Legs
                
Arms
                
Abdomen
                
Chest
                
A crisis can be brought on by
                
Illness
                
Temperature changes
                
Stress
                
Dehydration (not drinking enough)
                
Being at high altitudes
                
But often a person does not know what triggers, or causes, the crisis. (See acute pain management.)
                
Chronic Pain
                
Many adolescents and adults with SCD suffer from chronic pain. This kind of pain has been hard for people to describe, but it is usually different from crisis pain or the pain that results from organ damage.
                
Chronic pain can be severe and can make life difficult. Its cause is not well understood. (See chronic pain management.)
                
Severe Anemia
                
People with SCD usually have mild to moderate anemia. At times, however, they can have severe anemia. Severe anemia can be life threatening. Severe anemia in an infant or child with SCD may be caused by:
                
Splenic sequestration crisis. The spleen is an organ that is located in the upper left side of the belly. The spleen filters germs in the blood, breaks up blood cells, and makes a kind of white blood cell. A splenic sequestration crisis occurs when red blood cells get stuck in the spleen, making it enlarge quickly. Since the red blood cells are trapped in the spleen, there are fewer cells to circulate in the blood. This causes severe anemia.  A big spleen may also cause pain in the left side of the belly. A parent can usuallypalpate or feel the enlarged spleen in the belly of his or her child.
                
A big spleen may also cause pain in the left side of the belly. A parent can usuallypalpate or feel the enlarged spleen in the belly of his or her child.
                
Aplastic crisis. This crisis is usually caused by a parvovirus B19 infection, also called fifth disease or slapped cheek syndrome. Parvovirus B19 is a very common infection, but in SCD it can cause the bone marrow to stop producing new red cells for a while, leading to severe anemia.
                
Splenic sequestration crisis and aplastic crisis most commonly occur in infants and children with SCD. Adults with SCD may also experience episodes of severe anemia, but these usually have other causes.
                
No matter the cause, severe anemia may lead to symptoms that include:
                
Shortness of breath
                
Being very tired
                
Feeling dizzy
                
Having pale skin
                
Babies and infants with severe anemia may feed poorly and seem very sluggish. (See anemia management.)
                
Infections
                
The spleen is important for protection against certain kinds of germs. Sickle cells can damage the spleen and weaken or destroy its function early in life.
                
People with SCD who have damaged spleens are at risk for serious bacterial infections that can be life-threatening. Some of these bacteria include:
                
Pneumococcus
                
Hemophilus influenza type B
                
Meningococcus
                
Salmonella
                
Staphylococcus
                
Chlamydia
                
Mycoplasma pneumoniae
                
Bacteria can cause:
                
Blood infection (septicemia)
                
Lung infection (pneumonia)
                
Infection of the covering of the brain and spinal cord (meningitis)
                
Bone infection (osteomyelitis)
                
(See how to prevent infections and infection management.)
                
Acute Chest Syndrome
                
Sickling in blood vessels of the lungs can deprive a persons lungs of oxygen. When this happens, areas of lung tissue are damaged and cannot exchange oxygen properly. This condition is known as acute chest syndrome. In acute chest syndrome, at least one segment of the lung is damaged.
                
This condition is very serious and should be treated right away at a hospital.
                
Acute chest syndrome often starts a few days after a painful crisis begins. A lung infection may accompany acute chest syndrome.
                
Symptoms may include:
                
Chest pain
                
Fever
                
Shortness of breath
                
Rapid breathing
                
Cough
                
(See acute chest syndrome management.)
                
Brain Complications
                
Clinical Stroke
                
A stroke occurs when blood flow is blocked to a part of the brain. When this happens, brain cells can be damaged or can die. In SCD, a clinical stroke means that a person shows outward signs that something is wrong. The symptoms depend upon what part of the brain is affected. Symptoms of stroke may include:
                
Weakness of an arm or leg on one side of the body
                
Trouble speaking, walking, or understanding
                
Loss of balance
                
Severe headache
                
As many as 24 percent of people with hemoglobin SS and 10 percent of people with hemoglobin SC may suffer a clinical stroke by age 45.
                
In children, clinical stroke occurs most commonly between the ages of 2 and 9, but recent prevention strategies have lowered the risk. (See Transcranial Doppler (TCD) Ultrasound Screening) and Red Blood Cell Transfusions.)
                
When people with SCD show symptoms of stroke, their families or friends should call 9-1-1 right away. (See clinical stroke management.)
                
Silent Stroke and Thinking Problems
                
Brain imaging and tests of thinking (cognitive studies) have shown that children and adults with hemoglobin SS and hemoglobin S0 thalassemia often have signs of silent brain injury, also called silent stroke. Silent brain injury is damage to the brain without showing outward signs of stroke.
                
This injury is common. Silent brain injury can lead to learning problems or trouble making decisions or holding down a job. (See Cognitive Screening and silent stroke management.)
                
Eye Problems
                
Sickle cell disease can injure blood vessels in the eye.
                
The most common site of damage is the retina, where blood vessels can overgrow, get blocked, or bleed. The retina is the light-sensitive layer of tissue that lines the inside of the eye and sends visual messages through the optic nerve to the brain.
                
Detachment of the retina can occur. When the retina detaches, it is lifted or pulled from its normal position. These problems can cause visual impairment or loss. (See Eye Examinations.)
                
Heart Disease
                
People with SCD can have problems with blood vessels in the heart and with heart function. The heart can become enlarged. People can also develop pulmonary hypertension.
                
People with SCD who have received frequent blood transfusions may also have heart damage from iron overload. (See transfusion management.)
                
Pulmonary Hypertension
                
In adolescents and adults, injury to blood vessels in the lungs can make it hard for the heart to pump blood through them. This causes the pressure in lung blood vessels to rise. High pressure in these blood vessels is called pulmonary hypertension. Symptoms may include shortness of breath and fatigue.
                
When this condition is severe, it has been associated with a higher risk of death. (See screening for pulmonary hypertension.)
                
Kidney Problems
                
The kidneys are sensitive to the effects of red blood cell sickling.
                
SCD causes the kidneys to have trouble making the urine as concentrated as it should be. This may lead to a need to urinate often and to have bedwetting or uncontrolled urination during the night (nocturnal enuresis). This often starts in childhood. Other problems may include:
                
Blood in the urine
                
Decreased kidney function
                
Kidney disease
                
Protein loss in the urine
                
Priapism
                
Males with SCD can have unwanted, sometimes prolonged, painful erections. This condition is called priapism.
                
Priapism happens when blood flow out of the erect penis is blocked by sickled cells. If it goes on for a long period of time, priapism can cause permanent damage to the penis and lead to impotence.
                
If priapism lasts for more than 4 hours, emergency medical care should be sought to avoid complications. (See priapism management.)
                
Gallstones
                
When red cells hemolyze, they release hemoglobin. Hemoglobin gets broken down into a substance called bilirubin. Bilirubin can form stones that get stuck in the gallbladder. The gallbladder is a small, sac-shaped organ beneath the liver that helps with digestion. Gallstones are a common problem in SCD.
                
Gallstones may be formed early on but may not produce symptoms for years. When symptoms develop, they may include:
                
Right-sided upper belly pain
                
Nausea
                
Vomiting
                
If problems continue or recur, a person may need surgery to remove the gallbladder.
                
Liver Complications
                
There are a number of ways in which the liver may be injured in SCD.
                
Sickle cell intrahepatic cholestasis is an uncommon, but severe, form of liver damage that occurs when sickled red cells block blood vessels in the liver. This blockage prevents enough oxygen from reaching liver tissue.
                
These episodes are usually sudden and may recur. Children often recover, but some adults may have chronic problems that lead to liver failure.
                
People with SCD who have received frequent blood transfusions may develop liver damage from iron overload.
                
Leg Ulcers
                
Sickle cell ulcers are sores that usually start small and then get larger and larger.
                
The number of ulcers can vary from one to many. Some ulcers will heal quickly, but others may not heal and may last for long periods of time. Some ulcers come back after healing.
                
People with SCD usually dont get ulcers until after the age of 10.
                
Joint Complications
                
Sickling in the bones of the hip and, less commonly, the shoulder joints, knees, and ankles, can decrease oxygen flow and result in severe damage. This damage is a condition called avascular or aseptic necrosis. This disease is usually found in adolescents and adults.
                
Symptoms include pain and problems with walking and joint movement. A person may need pain medicines, surgery, or joint replacement if symptoms persist.
                
Delayed Growth and Puberty
                
Children with SCD may grow and develop more slowly than their peers because of anemia. They will reach full sexual maturity, but this may be delayed.
                
Pregnancy
                
Pregnancies in women with SCD can be risky for both the mother and the baby.
                
Mothers may have medical complications including:
                
Infections
                
Blood clots
                
High blood pressure
                
Increased pain episodes
                
They are also at higher risk for:
                
Miscarriages
                
Premature births
                
Small-for-dates babies or underweight babies
                
(See pregnancy management.)
                
Mental Health
                
As in other chronic diseases, people with SCD may feel sad and frustrated at times. The limitations that SCD can impose on a persons daily activities may cause them to feel isolated from others. Sometimes they become depressed.
                
People with SCD may also have trouble coping with pain and fatigue, as well as with frequent medical visits and hospitalizations. (See living with emotional issues.)