bonito_variation

ncbi_mcqa/ncbi_summary_mcqa.json

@@ -1,10 +1,20 @@
-{"input": "Given this review: \"A1BG, Official Symbol A1BGprovided by HGNC Official Full Name alpha-1-B glycoproteinprovided by HGNC Primary source HGNC:HGNC:5 See related Ensembl:ENSG00000121410 MIM:138670; AllianceGenome:HGNC:5 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1B; ABG; GAB; HYST2477 Summary The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008] Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Maybe"}
+{"input": "Given this review: \"A1BG, Official Symbol A1BGprovided by HGNC Official Full Name alpha-1-B glycoproteinprovided by HGNC Primary source HGNC:HGNC:5 See related Ensembl:ENSG00000121410 MIM:138670; AllianceGenome:HGNC:5 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1B; ABG; GAB; HYST2477 Summary The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008] Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A1BG-AS1, Official Symbol A1BG-AS1provided by HGNC Official Full Name A1BG antisense RNA 1provided by HGNC Primary source HGNC:HGNC:37133 See related Ensembl:ENSG00000268895 AllianceGenome:HGNC:37133 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1BGAS; A1BG-AS; NCRNA00181 Expression Biased expression in liver (RPKM 106.5) and spleen (RPKM 1.9) See more\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A1CF, Official Symbol A1CFprovided by HGNC Official Full Name APOBEC1 complementation factorprovided by HGNC Primary source HGNC:HGNC:24086 See related Ensembl:ENSG00000148584 MIM:618199; AllianceGenome:HGNC:24086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACF; ASP; ACF64; ACF65; APOBEC1CF Summary Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Biased expression in liver (RPKM 31.2), small intestine (RPKM 8.6) and 4 other tissues See more Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
-{"input": "What is the answer for the question: What is the name of the protein that uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases? from the following article ?\n\nA2M, Official Symbol A2Mprovided by HGNC Official Full Name alpha-2-macroglobulinprovided by HGNC Primary source HGNC:HGNC:7 See related Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MD; CPAMD5; FWP007; S863-7 Summary The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] Expression Broad expression in lung (RPKM 732.0), urinary bladder (RPKM 374.7) and 21 other tissues See more Orthologs all", "output": "alpha-2-macroglobulin"}
-{"input": "What is the answer for the question: What is the full name of the gene that has broad expression in the lung and liver? from the following options:\n- A2M-AS1\n - A2M antisense RNA 1\n - A2M antisense RNA 2\n - A2M antisense RNA 3\n - A2M antisense RNA 4\n - A2M antisense RNA 5\n - A2M antisense RNA 6\n - A2M antisense RNA 7", "output": "A2M-AS1"}
+{"input": "What is the answer for the question: What is the name of the protein that is a protease inhibitor and cytokine transporter? from the following article ?\n\nA2M, Official Symbol A2Mprovided by HGNC Official Full Name alpha-2-macroglobulinprovided by HGNC Primary source HGNC:HGNC:7 See related Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MD; CPAMD5; FWP007; S863-7 Summary The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] Expression Broad expression in lung (RPKM 732.0), urinary bladder (RPKM 374.7) and 21 other tissues See more Orthologs all", "output": "alpha-2-macroglobulin"}
+{"input": "What is the answer for the question: What is the official symbol for the gene that has broad expression in lung (RPKM 20.8), liver (RPKM 9.6) and 21 other tissues? from the following options:\n- A2M-AS1\n - A2M antisense RNA 1\n - A2M\n - ENSG00000245105\n - Eukaryota\n - HGNC\n - Homo\n - Euarchontoglires", "output": "A2M-AS1"}
 {"input": "Given this review: \"A2ML1, Official Symbol A2ML1provided by HGNC Official Full Name alpha-2-macroglobulin like 1provided by HGNC Primary source HGNC:HGNC:23336 See related Ensembl:ENSG00000166535 MIM:610627; AllianceGenome:HGNC:23336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OMS; p170; CPAMD9 Summary This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] Expression Restricted expression toward esophagus (RPKM 190.0) See more Orthologs all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A2ML1-AS1, Official Symbol A2ML1-AS1provided by HGNC Official Full Name A2ML1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41022 See related AllianceGenome:HGNC:41022 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A2MP1, Official Symbol A2MP1provided by HGNC Official Full Name alpha-2-macroglobulin pseudogene 1provided by HGNC Primary source HGNC:HGNC:8 See related Ensembl:ENSG00000291190 AllianceGenome:HGNC:8 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MP Expression Biased expression in adrenal (RPKM 1.1), spleen (RPKM 0.5) and 11 other tissues See more\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A3GALT2, Official Symbol A3GALT2provided by HGNC Official Full Name alpha 1,3-galactosyltransferase 2provided by HGNC Primary source HGNC:HGNC:30005 See related Ensembl:ENSG00000184389 MIM:619850; AllianceGenome:HGNC:30005 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGB3S; IGBS3S; A3GALT2P Summary Predicted to enable N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
 {"input": "Given this review: \"A4GALT, Official Symbol A4GALTprovided by HGNC Official Full Name alpha 1,4-galactosyltransferase (P blood group)provided by HGNC Primary source HGNC:HGNC:18149 See related Ensembl:ENSG00000128274 MIM:607922; AllianceGenome:HGNC:18149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1 Summary The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in kidney (RPKM 6.5), fat (RPKM 5.5) and 22 other tissues See more Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "Given this review: \"A4GNT, Official Symbol A4GNTprovided by HGNC Official Full Name alpha-1,4-N-acetylglucosaminyltransferaseprovided by HGNC Primary source HGNC:HGNC:17968 See related Ensembl:ENSG00000118017 MIM:616709; AllianceGenome:HGNC:17968 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as alpha4GnT Summary This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008] Expression Biased expression in stomach (RPKM 9.5), duodenum (RPKM 0.9) and 1 other tissue See more Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "Given this review: \"AA06, Gene symbol AA06 Gene description uncharacterized LOC100506677 See related Ensembl:ENSG00000265544 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AA02; AA04; AA05 Expression Low expression observed in reference dataset See more\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "AAAS, Official Symbol AAASprovided by HGNC Official Full Name aladin WD repeat nucleoporinprovided by HGNC Primary source HGNC:HGNC:13666 See related Ensembl:ENSG00000094914 MIM:605378; AllianceGenome:HGNC:13666 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AAA; AAASb; GL003; ALADIN; ADRACALA; ADRACALIN Summary The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in testis (RPKM 20.2), adrenal (RPKM 16.0) and 25 other tissues See more Orthologs mouse all\nQuestion: What is the primary source of the information?\nOptions:\n- not enough information \n - HGNC \n - Ensembl \n - AllianceGenome\n===\nThe correct answer is", "output": "HGNC"}
+{"input": "Given this review: \"AACS, Official Symbol AACSprovided by HGNC Official Full Name acetoacetyl-CoA synthetaseprovided by HGNC Primary source HGNC:HGNC:21298 See related Ensembl:ENSG00000081760 MIM:614364; AllianceGenome:HGNC:21298 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACSF1; SUR-5 Summary Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Expression Ubiquitous expression in fat (RPKM 23.3), skin (RPKM 16.5) and 24 other tissues See more Orthologs mouse all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "Given this review: \"AACSP1, Official Symbol AACSP1provided by HGNC Official Full Name acetoacetyl-CoA synthetase pseudogene 1provided by HGNC Primary source HGNC:HGNC:18226 See related Ensembl:ENSG00000291019 AllianceGenome:HGNC:18226 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as AACSL Expression Restricted expression toward testis (RPKM 1.9) See more\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "What is the answer for the question: What is the full name of the gene that competes against the activity of cytosolic arylamine N-acetyltransferase? from the following options:\n- arylacetamide deacetylase\n - HGNC\n - DAC\n - CES5A1\n - Haplorrhini\n - HGNC:17\n - Homo sapiens\n - ENSG00000114771", "output": "arylacetamide deacetylase"}
+{"input": "Given this review: \"AADACL2, Official Symbol AADACL2provided by HGNC Official Full Name arylacetamide deacetylase like 2provided by HGNC Primary source HGNC:HGNC:24427 See related Ensembl:ENSG00000197953 AllianceGenome:HGNC:24427 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Summary Predicted to enable hydrolase activity. Predicted to be located in extracellular region. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Expression Restricted expression toward skin (RPKM 21.5) See more Orthologs all\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "Given this review: \"AADACL2-AS1, Official Symbol AADACL2-AS1provided by HGNC Official Full Name AADACL2 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:50301 See related AllianceGenome:HGNC:50301 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Biased expression in testis (RPKM 1.2), placenta (RPKM 0.2) and 2 other tissues See more\"\nWould you recommend this app to a friend? Not at all, No, Maybe, Yes, or Definitely?", "output": "Definitely"}
+{"input": "What is the answer for the question: What is the name of the group that provides the Official Symbol AADACL3? from the following options:\n- AllianceGenome\n - Alliance of Genome Resources\n - HGNC\n - ENSG00000188984", "output": "Alliance of Genome Resources"}
+{"input": "What is the answer for the question: What is the full name of the gene type protein coding that is VALIDATED? from the following options:\n- AADACL4\n - EADACL4\n - AADACL2\n - AADACL3\n - not enough information\n - AADACL5", "output": "AADACL4"}