abstract_id
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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
25267532
2methods
Two researchers coded data blind , using thematic analysis .
6
700
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25267532
4results
( i ) Caregivers and patients express a need for post-discharge support .
7
701
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25267532
4results
( ii ) Patients identify helpful and unhelpful support strategies , useful for developing future interventions .
8
702
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25267532
4results
( iii ) Patients could identify positive caregiver behaviour changes targeted in intervention .
9
703
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25267532
4results
( iv ) Guided self-help may benefit caregiver and sufferer , post-discharge .
10
704
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25267532
1conclusions
Caregiver interventions can be a useful tool that will improve the cost effectiveness of inpatient treatment by enhancing the well-being of caregivers and patients .
11
705
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24799513
0background
Cardiac mortality and electrophysiological dysfunction both increase with age .
0
706
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24799513
0background
Heart rate variability ( HRV ) provides indices of autonomic function and electrophysiology that are associated with cardiac risk .
1
707
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24799513
0background
How habitual physical activity among older adults prospectively relates to HRV , including nonlinear indices of erratic sinus patterns , is not established .
2
708
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24799513
0background
We hypothesized that increasing the levels of both total leisure-time activity and walking would be prospectively associated with more favorable time-domain , frequency-domain , and nonlinear HRV measures in older adults .
3
709
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24799513
4results
We evaluated serial longitudinal measures of both physical activity and @-hour Holter HRV over @ years among @ older US adults in the community-based Cardiovascular Health Study .
4
710
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24799513
4results
After multivariable adjustment , greater total leisure-time activity , walking distance , and walking pace were each prospectively associated with specific , more favorable HRV indices , including higher @-hour standard deviation of all normal-to-normal intervals ( Ptrend = @ , @ , @ , respectively ) and ultralow-frequency power ( Ptrend = @ , @ , @ , respectively ) .
5
711
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24799513
4results
Greater walking pace was also associated with a higher short-term fractal scaling exponent ( Ptrend = @ ) and lower Poincar ratio ( Ptrend = @ ) , markers of less erratic sinus patterns .
6
712
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24799513
1conclusions
Greater total leisure-time activity , and walking alone , as well , were prospectively associated with more favorable and specific indices of autonomic function in older adults , including several suggestive of more normal circadian fluctuations and less erratic sinoatrial firing .
7
713
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24799513
1conclusions
Our results suggest potential mechanisms that might contribute to lower cardiovascular mortality with habitual physical activity later in life .
8
714
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24573358
3objective
Our aim was to compare anatomical and functional outcome between vaginal colposuspension and transvaginal mesh .
0
715
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24573358
2methods
This was a prospective randomized controlled trial in a teaching hospital .
1
716
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24573358
2methods
Sixty-eight women with stage @ anterior vaginal wall prolapse according to the Pelvic Organ Prolapse Quantification ( POP-Q ) system were assessed , randomized , and analyzed .
2
717
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24573358
2methods
Patients were randomized to anterior colporrhaphy with vaginal colposuspension ( n = @ ) or transvaginal mesh ( n = @ ) .
3
718
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24573358
2methods
Primary outcome was objective cure rate of the anterior vaginal wall , defined as POP-Q @ at @years .
4
719
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24573358
2methods
Secondary outcomes were functional results , quality-of-life ( QoL ) scores , mesh-related morbidity , and onset of urinary incontinence .
5
720
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24573358
4results
The anatomical result for point Ba was significantly better at @years in the mesh group ( -@ cm ) than in the colposuspension group ( -@ cm ) ( p = @ ) .
6
721
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24573358
4results
Concerning POP-Q stages , the anatomical success rate at @years was @ % for colposuspension and @ % for mesh ( p = @ ) .
7
722
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24573358
4results
There were @ anatomic recurrences ( @ % ) in the colposuspension group .
8
723
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24573358
4results
The erosion rate was @ % ( n = @ ) .
9
724
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24573358
4results
No significant difference was noted regarding minor complications .
10
725
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24573358
4results
Analysis of QoL questionnaires showed overall improvement in both groups , with no significant difference between them .
11
726
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24573358
1conclusions
The vaginal colposuspension technique of anterior vaginal wall prolapse repair gave good anatomical and functional results at @years .
12
727
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24573358
1conclusions
Transobturator vaginal mesh gave better @-year anatomical results than vaginal colposuspension , with overall improvement in QoL in both groups .
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25249651
3objective
Clinical studies evaluating the effects of medications on - cell function in type @ diabetes ( T@DM ) are compromised by an inability to determine the actual baseline degree of - cell dysfunction independent of the reversible dysfunction induced by hyperglycemia ( glucotoxicity ) .
0
729
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25249651
3objective
Short-term intensive insulin therapy ( IIT ) is a strategy for eliminating glucotoxicity before randomization .
1
730
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25249651
3objective
This study determined whether liraglutide can preserve - cell function over @ weeks in early T@DM following initial elimination of glucotoxicity with IIT .
2
731
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25249651
2methods
In this double-blind , randomized , placebo-controlled trial , @ patients with T@DM of @ @ years ' duration and an A@C of @ @ % ( @ @ mmol/mol ) completed @ weeks of IIT before randomization to daily subcutaneous liraglutide or placebo injection , with serial assessment of - cell function by Insulin Secretion-Sensitivity Index-@ ( ISSI-@ ) on oral glucose tolerance test performed every @ weeks .
3
732
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25249651
4results
The primary outcome of baseline-adjusted ISSI-@ at @ weeks was higher in the liraglutide group than in the placebo group ( @ @ vs. @ @ , P = @ ) .
4
733
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25249651
4results
Baseline-adjusted HbA@c at @ weeks was lower in the liraglutide group ( @ @ % vs. @ @ % , P = @ ) ( @ @ vs. @ @ mmol/mol ) .
5
734
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25249651
4results
At each quarterly assessment , > @ % of participants on liraglutide had an HbA@c @ % ( @ mmol/mol ) and glucose tolerance in the nondiabetic range .
6
735
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25249651
4results
Despite this level of glycemic control , no difference was found in the incidence of hypoglycemia between the liraglutide and placebo groups ( P = @ ) .
7
736
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25249651
4results
Two weeks after stopping treatment , however , the beneficial effect on ISSI-@ of liraglutide versus placebo was entirely lost ( @ @ vs. @ @ , P = @ ) .
8
737
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25249651
1conclusions
Liraglutide provides robust enhancement of - cell function that is sustained over @ weeks in early T@DM but lost upon cessation of therapy .
9
738
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25110443
3objective
To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography ( ERCP ) pancreatitis and hyperamylasaemia in a multicentre study .
0
739
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25110443
2methods
A prospective , randomised , placebo-controlled multicentre study in five endoscopic units was conducted on @ patients randomised to receive a suppository containing @ mg indomethacin , or an inert placebo , @-@ min before ERCP .
1
740
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25110443
2methods
Post-ERCP pancreatitis and hyperamylasaemia were evaluated @ h following the procedure on the basis of clinical signs and laboratory parameters , and computed tomography/magnetic resonance imaging findings if required .
2
741
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25110443
4results
Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation .
3
742
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25110443
4results
The results of @ investigations were evaluated : @ in the indomethacin group and @ in the placebo group .
4
743
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25110443
4results
The distributions of the risk factors in the two groups did not differ significantly .
5
744
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25110443
4results
Pancreatitis developed in @ patients ( @ % ) : it was mild in @ ( @ % ) and severe in eight ( @ % ) cases .
6
745
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25110443
4results
Hyperamylaesemia occurred in @ patients ( @ % ) .
7
746
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25110443
4results
There was no significant difference between the indomethacin and placebo groups in the incidence of either post-ERCP pancreatitis ( @ % vs @ % ) or hyperamylasaemia ( @ % vs @ % ) .
8
747
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25110443
4results
Similarly , subgroup analysis did not reveal any significant differences between the two groups .
9
748
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25110443
1conclusions
@ mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis .
10
749
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24249722
0background
We sought to determine the incidence of newly diagnosed diabetes in treated elderly hypertensive patients and the prognostic impact of diabetes on long-term survival .
0
750
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24249722
2methods
The Second Australian National Blood Pressure ( ANBP@ ) study randomized @,@ hypertensive patients aged @-@ years to angiotensin-converting enzyme inhibitor ( ACEI ) or thiazide diuretic-based therapy and followed them for a median of @ years .
1
751
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24249722
2methods
Long-term survival was determined in @,@ patients over an additional median of @ years after ANBP@ ( post-trial ) .
2
752
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24249722
4results
After ANBP@ , the cohort was classified into preexisting ( @ % ) , newly diagnosed ( @ % ) , and no diabetes ( @ % ) groups .
3
753
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24249722
4results
A @ % higher incidence of newly diagnosed diabetes was observed in patients randomized to thiazide diuretic compared with ACEI-based treatment .
4
754
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24249722
4results
The other predictors of newly diagnosed diabetes were having a higher body mass index , having a higher random blood glucose , and living in a regional location compared to major cities ( a geographical classification based on accessibility ) at study entry .
5
755
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24249722
4results
After completion of ANBP@ , compared with those with no diabetes , the preexisting diabetes group experienced higher cardiovascular ( hazards ratio ( HR ) = @ ; @ % confidence interval ( CI ) = @-@ @ ) and all-cause mortality ( HR = @ ; @ % CI = @-@ @ ) when adjusted for age , sex , and treatment .
6
756
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24249722
4results
A similar pattern was observed after including the post-trial period for cardiovascular ( HR = @ ; @ % CI = @-@ @ ) and all-cause mortality ( HR = @ ; @ % CI = @-@ @ ) .
7
757
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24249722
4results
However , when the newly diagnosed group was compared with the no diabetes group , no significant difference was observed in cardiovascular ( HR = @ ; @ % CI = @-@ @ ) or all-cause mortality ( HR = @ ; @ % CI = @-@ @ ) either during the ANBP@ trial or including post-trial follow-up ( cardiovascular : HR = @ ; @ % CI = @-@ @ ; all-cause mortality : HR = @ ; @ % CI = @-@ @ ) .
8
758
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24249722
1conclusions
Long-term presence of diabetes reduces survival .
9
759
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24249722
1conclusions
Compared with thiazide diuretics , ACEI-based antihypertensives may delay the development of diabetes in those at risk and thus potentially improve cardiovascular outcome in the elderly .
10
760
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25027286
0background
Obesity is associated with a risk of gastroesophageal reflux disease .
0
761
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25027286
0background
The pharmacodynamic efficacy of proton pump inhibitors has not been specifically evaluated in obese subjects .
1
762
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25027286
0background
The aim of this study was to compare the antisecretory response to a single oral dose of @ mg rabeprazole , @ mg omeprazole and placebo in obese subjects .
2
763
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25027286
2methods
Gastric pH was monitored for @ hours on three separate occasions in eighteen H. pylori-negative , asymptomatic obese subjects .
3
764
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25027286
2methods
Subjects were given omeprazole , rabeprazole or placebo in a randomized order and in a double-blind fashion .
4
765
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25027286
2methods
The main analysis criterion was @-h percent of time post dose with intragastric pH above @ ; secondary criteria were percentage of time above pH @ , median pH , -LSB- H + -RSB- concentrations and nocturnal acid breakthrough ( NAB ) .
5
766
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25027286
2methods
Results were analyzed using linear mixed models and Wilks test comparing variances .
6
767
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25027286
4results
@-h median -LSB- IQ -RSB- percentages of time with gastric pH above @ and @ were higher with rabeprazole than omeprazole ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- % , @ -LSB- @-@ -RSB- % for placebo ) but the differences did not reach statistical significance ( p = @ and @ , respectively ) .
7
768
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25027286
4results
Median acid concentrations were significantly lower with rabeprazole than with omeprazole and placebo ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- and @ -LSB- @-@ -RSB- mmoles/l , p < @ ) for all periods .
8
769
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25027286
4results
The number of NAB was significantly lower with rabeprazole than with omeprazole ( median @ -LSB- @,@ -RSB- vs. @ -LSB- @-@ -RSB- , p = @ ) .
9
770
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25027286
4results
Variances of @-h data ( pH above @ and @ , median pH , -LSB- H + -RSB- concentrations ) were significantly lower with rabeprazole than with omeprazole ( p < @ ) .
10
771
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25027286
1conclusions
In asymptomatic obese subjects the gastric antisecretory response to a single dose of rabeprazole and omeprazole was strong and not significantly different between drugs despite a significantly more homogeneous response with rabeprazole .
11
772
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25439809
3objective
To study the effect of growth hormone ( GH ) treatment on ovarian and uterine morphology and function in short , prepubertal small-for-gestational-age ( SGA ) girls .
0
773
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25439809
2methods
A multinational , randomized controlled trial on safety and efficacy of GH therapy in short , prepubertal children born SGA .
1
774
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25439809
2methods
Not applicable .
2
775
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25439809
2methods
A subgroup of @ Danish girls born SGA included in North European SGA Study ( NESGAS ) .
3
776
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25439809
2methods
One year of GH treatment ( @ g/kg/day ) followed by @ years of randomized GH treatment ( @ g/kg/day , @ g/kg/day , or IGF-I titrated ) .
4
777
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25439809
2methods
Data on anthropometrics , reproductive hormones , and ultrasonographic examination of the internal genitalia were collected during @ months of GH treatment .
5
778
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25439809
4results
Uterine and ovarian volume increased significantly during @ years of treatment ( @ % and @ % , respectively ) but remained low within normal reference ranges .
6
779
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25439809
4results
Ovarian follicles became visible in @ % after @ year compared with @ % before GH therapy .
7
780
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25439809
4results
Anti-Mllerian hormone increased significantly during the @ years of GH therapy but remained within the normal range .
8
781
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25439809
4results
Precocious puberty was observed in one girl ; another girl developed multicystic ovaries .
9
782
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25439809
1conclusions
GH treatment was associated with statistically significant growth of the internal genitalia , but remained within the normal range .
10
783
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25439809
1conclusions
As altered pubertal development and ovarian morphology were found in @ of @ girls , monitoring of puberty and ovarian function during GH therapy in SGA girls is prudent .
11
784
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25439809
1conclusions
Altogether , the findings are reassuring .
12
785
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25439809
1conclusions
However , long-term effects of GH treatment on adult reproductive function remain unknown .
13
786
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24898858
3objective
To test the hypothesis that a brief , clinic-based , single-session programme will reduce the rate of @ selected condom use errors in a clinical sample of young black men ( YBM ) ages @ through @ years .
0
787
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24898858
2methods
Data were collected in clinics treating patients with sexually transmitted infections ( STI ) in three southern US cities .
1
788
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24898858
2methods
Males @-@years of age who identified as black/African-American , and reported recent ( past @months ) condom use were eligible .
2
789
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24898858
2methods
Only those also reporting condom use in the @months prior to a @-month follow-up assessment ( n = @ ) were included in this secondary analysis of data from a randomised , controlled trial .
3
790
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24898858
2methods
Difference scores were used to capture a GroupTime effect .
4
791
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24898858
4results
YBM reported @ condom use events in the @months preceding study enrolment and @ in the @months preceding the follow-up assessment .
5
792
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24898858
4results
Mean baseline error rates were @ and @ for young men randomised to the intervention and control conditions , respectively .
6
793
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24898858
4results
Follow-up rates were @ and @ for young men randomised to the intervention and control conditions , respectively .
7
794
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24898858
4results
Controlled findings yielded a significant effect for the influence of group assignment on the difference score ( baseline to follow-up ) in the condom use error rate ( = @ ; p = @ ) .
8
795
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24898858
1conclusions
A brief , clinic-based counselling programme produced modest reductions in condom use errors among YBM attending STI clinics in the southern USA Intensified clinic-based intervention that helps YBM improve the quality of their condom use behaviours is warranted .
9
796
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24672940
3objective
To provide evidence for Chinese medical treatment of children with EB virus infection by exploring its clinical efficacy from multiple angles .
0
797
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24672940
2methods
Totally @ children patients were randomly assigned to the treatment group ( @ cases ) and the control group ( @ cases ) .
1
798
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24672940
2methods
Patients in the treatment group took Chinese medical decoction , while those in the control received intravenous dripping of Ganciclovir and oral administration of pidotimod .
2
799
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