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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
25227656
1conclusions
Efficacy and safety profiles for pazopanib in this extension study of patients with RCC previously treated with placebo were very similar to those observed for pazopanib-treated patients in the pivotal phase III study .
11
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24831979
0background
An established multivariate serum protein test can be used to classify patients according to whether they are likely to have a good or poor outcome after treatment with EGFR tyrosine-kinase inhibitors .
0
901
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24831979
0background
We assessed the predictive power of this test in the comparison of erlotinib and chemotherapy in patients with non-small-cell lung cancer .
1
902
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24831979
2methods
From Feb @ , @ , to April @ , @ , patients ( aged @ years ) with histologically or cytologically confirmed , second-line , stage IIIB or IV non-small-cell lung cancer were enrolled in @ centres in Italy .
2
903
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24831979
2methods
Patients were stratified according to a minimisation algorithm by Eastern Cooperative Oncology Group performance status , smoking history , centre , and masked pretreatment serum protein test classification , and randomly assigned centrally in a @:@ ratio to receive erlotinib ( @ mg/day , orally ) or chemotherapy ( pemetrexed @ mg/m ( @ ) , intravenously , every @ days , or docetaxel @ mg/m ( @ ) , intravenously , every @ days ) .
3
904
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24831979
2methods
The proteomic test classification was masked for patients and investigators who gave treatments , and treatment allocation was masked for investigators who generated the proteomic classification .
4
905
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24831979
2methods
The primary endpoint was overall survival and the primary hypothesis was the existence of a significant interaction between the serum protein test classification and treatment .
5
906
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24831979
2methods
Analyses were done on the per-protocol population .
6
907
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24831979
2methods
This trial is registered with ClinicalTrials.gov , number NCT@ .
7
908
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24831979
4results
@ patients were randomly assigned to chemotherapy and @ to erlotinib , and @ ( @ % ) and @ ( @ % ) , respectively , were included in the per-protocol analysis .
8
909
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24831979
4results
@ ( @ % ) patients in the chemotherapy group and @ ( @ % ) in the erlotinib group had a proteomic test classification of good .
9
910
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24831979
4results
Median overall survival was @ months ( @ % CI @-@ ) in the chemotherapy group and @ months ( @-@ ) in the erlotinib group .
10
911
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24831979
4results
We noted a significant interaction between treatment and proteomic classification ( pinteraction = @ when adjusted for stratification factors ; pinteraction = @ when unadjusted for stratification factors ) .
11
912
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24831979
4results
Patients with a proteomic test classification of poor had worse survival on erlotinib than on chemotherapy ( hazard ratio @ -LSB- @ % CI @-@ -RSB- , p = @ ) .
12
913
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24831979
4results
There was no significant difference in overall survival between treatments for patients with a proteomic test classification of good ( adjusted HR @ -LSB- @-@ -RSB- , p = @ ) .
13
914
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24831979
4results
In the group of patients who received chemotherapy , the most common grade @ or @ toxic effect was neutropenia ( @ -LSB- @ % -RSB- vs one -LSB- < @ % -RSB- in the erlotinib group ) , whereas skin toxicity ( one -LSB- < @ % -RSB- vs @ -LSB- @ % -RSB- ) was the most frequent in the erlotinib group .
14
915
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24831979
1conclusions
Our findings indicate that serum protein test status is predictive of differential benefit in overall survival for erlotinib versus chemotherapy in the second-line setting .
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24831979
1conclusions
Patients classified as likely to have a poor outcome have better outcomes on chemotherapy than on erlotinib .
16
917
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25137430
3objective
This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure ( IOP ) in patients undergoing robot-assisted laparoscopic radical prostatectomy ( RALRP ) in the steep Trendelenburg ( ST ) .
0
918
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25137430
2methods
Sixty-eight patients were randomly divided into two groups .
1
919
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25137430
2methods
The dexmedetomidine group ( Group D , n = @ ) received a continuous infusion of dexmedetomidine at a rate of @ g kg ( -@ ) hour ( -@ ) from the induction of anesthesia until the end of the ST position , while the control group ( Group C , n = @ ) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil .
2
920
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25137430
2methods
IOP was measured at @ predefined time points for all patients .
3
921
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25137430
4results
Significant differences in IOP were detected between the two groups by a linear mixed model analysis ( p < @ ) .
4
922
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25137430
4results
The highest mean IOP was @ mm Hg in Group D and @ mm Hg in Group C ; both were measured @ minutes after the patients had been placed in the ST position .
5
923
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25137430
4results
No significant between-group differences in ocular perfusion pressure , mean blood pressure , or heart rate were observed between the two groups .
6
924
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25137430
4results
No ocular or other complications were noted .
7
925
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25137430
1conclusions
Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position .
8
926
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25514543
3objective
Disruptive or challenging behavior problems pose a threat to children and adolescents with intellectual disabilities and their caregivers .
0
927
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25514543
3objective
Psychopharmacological treatment is mostly studied with new-generation antipsychotics and has been criticized for adverse side effects .
1
928
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25514543
3objective
This study examined the effect of the classic antipsychotic zuclopenthixol .
2
929
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25514543
2methods
A total of @ boys ( ages @-@ @ years ) with learning disabilities were included and examined for a response to zuclopenthixol during a @ week period of open label treatment .
3
930
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25514543
2methods
Doses started low and were adapted individually .
4
931
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25514543
2methods
From responders , zuclopenthixol was randomly withdrawn for @ weeks .
5
932
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25514543
2methods
Responses to withdrawal were observed by external raters using the Modified Overt Aggression Scale .
6
933
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25514543
4results
Of all patients included into the study , @ were not randomized because of insufficient therapeutic effect , adverse event , or noncompliance .
7
934
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25514543
4results
Kaplan-Meier estimations showed less aggressive behavior problems for the continuing subgroup ( n = @ ) than in the placebo group ( n = @ ) .
8
935
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25514543
4results
Individual doses stayed < @mg/day .
9
936
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25514543
1conclusions
Zuclopenthixol proved to be effective in reducing challenging behavior in boys even at low doses .
10
937
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25925990
3objective
The purpose of this multicenter , open label , randomized phase III study was to determine whether ixabepilone resulted in improved overall survival ( OS ) compared with commonly used single-agent chemotherapy ( doxorubicin or paclitaxel ) in women with locally advanced , recurrent , or metastatic endometrial cancer with at least one failed prior platinum-based chemotherapeutic regimen .
0
938
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25925990
2methods
Patients were randomized @:@ to ixabepilone ( @mg/m ( @ ) ) , or either paclitaxel ( @mg/m ( @ ) ) or doxorubicin ( @mg/m ( @ ) ) , every @days .
1
939
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25925990
2methods
Patients that had previously received an anthracycline were randomized to ixabepilone or paclitaxel ; all other patients were randomized to ixabepilone or doxorubicin .
2
940
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25925990
2methods
An interim analysis of futility for OS was planned .
3
941
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25925990
4results
At the time of database lock , @ patients were randomized to receive ixabepilone ( n = @ ) or control ( n = @ ) ; nine patients in the control arm were not treated .
4
942
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25925990
4results
The interim analysis of futility for OS ( @ events ) favored the control chemotherapy arm ( hazard ratio = @ -LSB- @ % confidence interval : @-@ @ -RSB- , stratified log rank test P = @ ) , indicating that the study would not meet its primary objective .
5
943
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25925990
4results
The study was discontinued based on the interim OS results .
6
944
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25925990
4results
The frequency of adverse events was comparable between the treatment arms .
7
945
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25925990
1conclusions
The study did not meet its primary objective of improving OS in the ixabepilone arm compared to the control chemotherapy arm .
8
946
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25925990
1conclusions
A favorable risk/benefit ratio was not observed for ixabepilone versus control at the time of the interim analysis .
9
947
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25925990
1conclusions
The safety results were consistent with the known safety profiles of ixabepilone and control .
10
948
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25252480
3objective
To determine the impact of calcium and phosphorus on radiological and biochemical characteristics of osteopenia in premature infants .
0
949
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25252480
2methods
The randomised clinical trial study was conducted at Valie-e-Asr Hospital of Zanjan city , Iran , from December @ to June @ .
1
950
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25252480
2methods
It involved monitoring @ premature neonates over a period of six months .
2
951
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25252480
2methods
The babies , who were fed with breast milk and @ units of vitamin D daily , were randomly divided into two equal groups .
3
952
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25252480
2methods
One group received supplement of calcium and phosphorus .
4
953
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25252480
2methods
Serum calcium , phosphorus and alkaline phosphatase levels as well as growth parameters ( including weight , height , and head circumference ) were measured every two weeks .
5
954
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25252480
2methods
At the end of the study , wrist X-ray was done for evaluation of osteopenia .
6
955
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25252480
2methods
Data was analysed using SPSS @ .
7
956
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25252480
4results
Radiological changes , characteristic of osteopenia , were found in @ ( @ % ) cases and @ ( @ % ) controls ( p < @ ) .
8
957
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25252480
4results
The mean of weight , length and head circumference increased significantly from second to sixth week during follow-up ( p < @ ) .
9
958
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25252480
4results
Phosphorus and alkaline phosphatase activity decreased significantly from second to sixth week of follow-up ( p < @ , p < @ respectively ) .
10
959
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25252480
4results
However , repeated measurement analyses did not show significant effect of intervention in biochemical and growth parameters in the trial group .
11
960
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25252480
1conclusions
The study did n't show significant effect of calcium and phosphorus on prevention of osteopenia and improvement of growth .
12
961
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25252480
1conclusions
Further studies of longer duration and with different doses of supplement are recommended .
13
962
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24720919
3objective
The purpose of this study was to test the efficacy of a @-month course of anti-inflammatory treatment with colchicinein improving functional status of patients with stable chronic heart failure ( CHF ) .
0
963
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24720919
0background
CHF has been shown to be associated with inflammatory activation .
1
964
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24720919
0background
Inflammation has been designated as a therapeutic target in CHF .
2
965
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24720919
2methods
Patients with stable CHF were randomly assigned to colchicine ( @ mg twice daily ) or placebo for @ months .
3
966
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24720919
2methods
Theprimary endpoint was the proportion of patients achieving at least one-grade improvement in New York HeartAssociation class .
4
967
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24720919
4results
Two hundred sixty-seven patients were available for final evaluation of the primary endpoint : its rate was @ % in the control group and @ % in the colchicine group ( odds ratio : @ ; @ % confidence interval : @ to @ ; p = @ ) .
5
968
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24720919
4results
The rate of the composite of death or hospital stay for heart failure was @ % in the control group , compared with @ % in the colchicine group ( p = @ ) .
6
969
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24720919
4results
The changes in treadmill exercise time with treatment were insignificant and similar in the @ groups ( p = @ ) .
7
970
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24720919
4results
C-reactive protein and interleukin-@ were both significantly reduced in the colchicine group ( -@ mg/l and -@ pg/ml , respectively ; p < @ for both , compared with the control group ) .
8
971
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24720919
1conclusions
According to this prospective , randomized study , anti-inflammatory treatment with colchicine in patients with stable CHF , although effective in reducing inflammation biomarker levels , did not affect in any significant way patient functional status ( in terms of New York Heart Association class and objective treadmill exercise tolerance ) or the likelihood of death or hospital stay for heart failure .
9
972
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24500245
3objective
To examine the comparative antidepressant efficacy of S-adenosyl-L-methionine ( SAMe ) and escitalopram in a placebo-controlled , randomized , double-blind clinical trial .
0
973
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24500245
2methods
One hundred eighty-nine outpatients ( @ % female , mean -LSB- SD -RSB- age = @ -LSB- @ -RSB- years ) with DSM-IV-diagnosed major depressive disorder ( MDD ) were recruited from April @ , @ , to December @ , @ , at the Massachusetts General Hospital and at Butler Hospital .
1
974
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24500245
2methods
Patients were randomized for @ weeks to SAMe @,@-@ ,@ mg/d , escitalopram @-@ mg/d , or placebo .
2
975
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24500245
2methods
Doses were escalated at @ weeks in the event of nonresponse .
3
976
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24500245
2methods
The main outcome measure was the @-item Hamilton Depression Rating Scale ( HDRS-@ ) .
4
977
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24500245
2methods
Tolerability was assessed by the Systematic Assessment for Treatment of Emergent Events-Specific Inquiry ( SAFTEE-SI ) .
5
978
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24500245
4results
All @ treatment arms demonstrated a significant improvement of about @-@ points in HDRS-@ scores ( P < @ for all ) , and no significant differences were observed between the treatment arms ( P > @ for all ) .
6
979
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24500245
4results
Response rates in the intent-to-treat sample were @ % for SAMe , @ % for escitalopram , and @ % for placebo .
7
980
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24500245
4results
Remission rates were @ % for SAMe , @ % for escitalopram , and @ % for placebo .
8
981
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24500245
4results
No comparisons between treatment groups attained significance ( P > @ for all ) .
9
982
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24500245
4results
Tolerability was good , with gastrointestinal side effects ( @ % for stomach discomfort and @ % for diarrhea ) as the most common in the SAMe arm .
10
983
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24500245
4results
Significant differences were observed between treatment groups for dizziness , anorgasmia , diminished mental acuity , and hot flashes ( P < @ for all ) .
11
984
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24500245
1conclusions
The results fail to support an advantage over placebo for either the investigational treatment SAMe or the standard treatment escitalopram for MDD .
12
985
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25833772
0background
Total weight loss induced by energy restriction is highly variable even under tightly controlled conditions .
0
986
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25833772
0background
Identifying weight-loss discriminants would provide a valuable weight management tool and insights into body weight regulation .
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25833772
3objective
This study characterized responsiveness to energy restriction in adults from variables including the plasma metabolome , endocrine and inflammatory markers , clinical indices , body composition , diet , and physical activity .
2
988
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25833772
2methods
Data were derived from a controlled feeding trial investigating the effect of @-@ dairy product servings in an energy-restricted diet ( @ kJ/d reduction ) over @ wk .
3
989
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25833772
2methods
Partial least squares regression was used to identify weight-loss discriminants in @ overweight and obese adults .
4
990
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25833772
2methods
Linear mixed models were developed to identify discriminant variable differences in high - vs. low-weight-loss responders .
5
991
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25833772
4results
Both pre - and postintervention variables ( n = @ ) were identified as weight-loss discriminants ( root mean squared error of prediction = @ kg ; Q ( @ ) = @ ) .
6
992
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25833772
4results
Compared with low-responders ( LR ) , high-responders ( HR ) had greater decreases in body weight ( LR : @ @ kg ; HR : @ @ kg , P < @ ) , BMI ( in kg/m ( @ ) ; LR : @ @ ; HR : @ @ , P < @ ) , and total fat ( LR : @ @ kg ; HR : @ @ kg , P < @ ) .
7
993
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25833772
4results
Significant group effects unaffected by the intervention were determined for the respiratory exchange ratio ( LR : @ @ ; HR : @ @ , P < @ ) , moderate physical activity ( LR : @ @ min ; HR : @ @ min , P = @ ) , sedentary activity ( LR : @ @ min ; HR : @ @ min , P = @ ) , and plasma stearate -LSB- LR : @,@ @,@ quantifier ion peak height ( QIPH ) ; HR : @,@ @,@ QIPH , P = @ -RSB- .
8
994
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25833772
1conclusions
Overweight and obese individuals highly responsive to energy restriction had accelerated reductions in adiposity , likely supported in part by higher lipid mobilization and combustion .
9
995
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25833772
1conclusions
A novel observation was that person-to-person differences in habitual physical activity and magnitude of weight loss were accompanied by unique blood metabolite signatures .
10
996
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25833772
1conclusions
This trial was registered at clinicaltrials.gov as NCT@ .
11
997
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24846454
0background
Endovascular repair of abdominal aortic aneurysm ( AAA ) has recently been made a class I indication in the treatment of AAA .
0
998
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24846454
0background
In comparison to the conventional open surgical treatment , endovascular AAA repair ( EVAR ) is associated with equivalent long-term morbidity and mortality rates .
1
999
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