abstract_id
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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24371021
4results
@ ( @ % ) of completers were re-randomized to the double-blinded maintenance of effect phase and @ ( @ % ) of them completed .
7
175,600
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24371021
4results
Improvement from baseline in DSM-IV ADHD RS ( P < @ for all comparisons ) and SDS ( @mg , P = @ ; @mg , P = @ ; @mg , P < @ ) total scores was significantly greater vs. placebo for all MPH-LA doses .
8
175,601
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24371021
4results
Treatment failure rate was significantly lower with MPH-LA ( @ % ) versus placebo ( @ % ) during the @-month maintenance of effect phase .
9
175,602
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24371021
4results
Safety profile was consistent with the profile for MPH-LA in children ; percentage of serious adverse events was comparable between all MPH-LA arms ( @ % ) and placebo ( @ % ) , while percentage of adverse events was higher in MPH-LA arms .
10
175,603
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24371021
1conclusions
MPH-LA provided and maintained significant symptomatic and functional improvement in adult ADHD patients .
11
175,604
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24347765
3objective
To compare the effect of melatonin and gabapentin on anxiety , pain , sedation scores , and satisfaction of surgeon in patients of cataract surgery .
0
175,605
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24347765
2methods
One hundred thirty patients aged between @ and @ years scheduled for cataract surgery were randomly allocated to three study groups to receive melatonin ( @ mg ) , gabapentin ( @ mg ) or placebo @ min before arrival in the operating room .
1
175,606
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24347765
2methods
Pain , anxiety , and sedation scores during block and surgery as well as the surgeon 's satisfaction with the surgery were assessed .
2
175,607
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24347765
4results
Anxiety scores decreased significantly in melatonin and gabapentin groups compared to the placebo group after premedication and extended to early postoperative period .
3
175,608
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24347765
4results
The level of anxiety showed no statistically significant difference between melatonin and gabapentin groups at any time of measurement .
4
175,609
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24347765
4results
There were significant differences between the pain scores during retrobulbar placement in gabapentin versus placebo ( @ % CI @ to @ ; P = @ ) and melatonin ( @ % CI @ to @ ; P = @ ) groups .
5
175,610
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24347765
4results
Also , there were significant differences between the sedation scores during retrobulbar placement in gabapentin and placebo groups ( @ % CI @ to @ ; P = @ ) .
6
175,611
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24347765
4results
The difference in sedation scores during retrobulbar placement in melatonin versus gabapentin and placebo groups was not significant .
7
175,612
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24347765
4results
Neither the intraoperative pain scores nor the postoperative pain scores were different between the three groups .
8
175,613
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24347765
4results
The surgeon reported similar quality of operation conditions during surgery for the three study groups .
9
175,614
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24347765
1conclusions
The level of anxiety was significantly lower with both anxiolytic drugs compared to placebo .
10
175,615
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24347765
1conclusions
Furthermore , gabapentin decreased the pain and improved the sedation scores only during retrobulbar placement compared to the placebo .
11
175,616
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26114906
3objective
To investigate whether a @-week physical and cognitive exercise program can improve cognitive function and brain activation efficiency in community-dwelling older adults .
0
175,617
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26114906
2methods
Randomized controlled trial .
1
175,618
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26114906
2methods
Kyoto , Japan .
2
175,619
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26114906
2methods
Community-dwelling older adults ( N = @ ) were randomized into an exercise group ( n = @ ) and a control group ( n = @ ) .
3
175,620
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26114906
2methods
Exercise group participants received a weekly dual task-based multimodal exercise class in combination with pedometer-based daily walking exercise during the @-week intervention phase .
4
175,621
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26114906
2methods
Control group participants did not receive any intervention and were instructed to spend their time as usual during the intervention phase .
5
175,622
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26114906
2methods
The outcome measures were global cognitive function , memory function , executive function , and brain activation ( measured using functional magnetic resonance imaging ) associated with visual short-term memory .
6
175,623
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26114906
4results
Exercise group participants had significantly greater postintervention improvement in memory and executive functions than the control group ( P < @ ) .
7
175,624
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26114906
4results
In addition , after the intervention , less activation was found in several brain regions associated with visual short-term memory , including the prefrontal cortex , in the exercise group ( P < @ , uncorrected ) .
8
175,625
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26114906
1conclusions
A @-week physical and cognitive exercise program can improve the efficiency of brain activation during cognitive tasks in older adults , which is associated with improvements in memory and executive function .
9
175,626
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24480335
3objective
To explore potential predictors of self-reported paretic arm use at baseline and after task-specific training ( TST ) in survivors of stroke .
0
175,627
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24480335
2methods
Data were obtained from a randomized controlled trial of somatosensory stimulation and upper limb TST in chronic stroke .
1
175,628
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24480335
2methods
University laboratory .
2
175,629
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24480335
2methods
Chronic ( @mo ) survivors of stroke ( N = @ ; mean age , @y ; mean stroke duration , @mo ) .
3
175,630
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24480335
2methods
Participants received @ sessions of TST preceded by either active ( n = @ ) or sham ( n = @ ) somatosensory stimulation to all @ peripheral nerves .
4
175,631
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24480335
2methods
Demographic and clinical characteristics were entered stepwise into multiple linear regression analyses to determine the factors that best predict baseline Motor Activity Log ( MAL ) amount of use rating and change @ months after TST .
5
175,632
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24480335
4results
The Action Research Arm Test ( ARAT ) score predicted the amount of use at baseline ( R ( @ ) = @ , P < @ ) ; in using this model , an ARAT score of @ ( maximum of @ ) is required to score @ on the MAL ( use described as between rarely and sometimes ) .
6
175,633
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24480335
4results
After TST the change in the ARAT score predicted the change in the amount of use ( R ( @ ) = @ , P = @ ) .
7
175,634
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24480335
4results
The predictive power of the model for change at @ months increased if the Fugl-Meyer Assessment wrist component score was added ( R ( @ ) = @ , P = @ ) .
8
175,635
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24480335
1conclusions
Utilization of the paretic upper limb in activities of daily living requires high functional ability .
9
175,636
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24480335
1conclusions
The increase in self-reported arm use after TST is dependent on the change in functional ability .
10
175,637
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24480335
1conclusions
These results provide further guidance for rehabilitation decisions .
11
175,638
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24269855
0background
There are limited data comparing ultrafiltration with standard medical therapy as first-line treatment in patients with severe congestive heart failure ( HF ) .
0
175,639
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24269855
0background
We compared ultrafiltration and conventional therapy in patients hospitalized for HF and overt fluid overload .
1
175,640
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24269855
4results
Fifty-six patients with congestive HF were randomized to receive standard medical therapy ( control group ; n = @ ) or ultrafiltration ( ultrafiltration group ; n = @ ) .
2
175,641
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24269855
4results
The primary end point of the study was rehospitalizations for congestive HF during a @-year follow-up .
3
175,642
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24269855
4results
Despite similar body weight reduction at hospital discharge in the @ groups ( @ @ and @ @ kg , respectively ; P = @ ) , a lower incidence of rehospitalizations for HF was observed in the ultrafiltration-treated patients during the following year ( hazard ratio @ , @ % confidence interval @-@ @ ; P = @ ) .
4
175,643
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24269855
4results
Ultrafiltration-induced benefit was associated with a more stable renal function , unchanged furosemide dose , and lower B-type natriuretic peptide levels .
5
175,644
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24269855
4results
At @ year , @ deaths ( @ % ) occurred in the ultrafiltration group and @ ( @ % ) in the control group ( P = @ ) .
6
175,645
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24269855
1conclusions
In HF patients with severe fluid overload , first-line treatment with ultrafiltration is associated with a prolonged clinical stabilization and a greater freedom from rehospitalization for congestive HF .
7
175,646
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24954822
3objective
Pediatric inflammatory bowel disease ( IBD ) is associated with high rates of depression .
0
175,647
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24954822
3objective
This study compared the efficacy of cognitive behavioral therapy ( CBT ) to supportive nondirective therapy ( SNDT ) in treating youth with comorbid IBD and depression .
1
175,648
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24954822
2methods
Youth ( @ % female and @ % male ; age @-@ years , mean age @ years ) with depression and Crohn 's disease ( n = @ ) or ulcerative colitis ( n = @ ) were randomly assigned to a @-month course of CBT or SNDT .
2
175,649
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24954822
2methods
The primary outcome was comparative reduction in depressive symptom severity ; secondary outcomes were depression remission , increase in depression response , and improved health-related adjustment and IBD activity .
3
175,650
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24954822
4results
A total of @ participants ( @ % ) completed the @-month intervention .
4
175,651
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24954822
4results
Both psychotherapies resulted in significant reductions in total Children 's Depression Rating Scale Revised score ( @ % for CBT and @ % for SNDT ) , but the difference between the @ treatments was not significant ( p = @ ) .
5
175,652
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24954822
4results
There were large pre-post effect sizes for each treatment ( d = @ for CBT and d = @ for SNDT ) .
6
175,653
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24954822
4results
More than @ % of youth had a complete remission of depression at @ months , with no difference between CBT and SNDT ( @ % and @ % , respectively ) .
7
175,654
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24954822
4results
Compared to SNDT , CBT was associated with a greater reduction in IBD activity ( p = @ ) but no greater improvement on the Clinical Global Assessment Scale ( p = @ ) and health-related quality of life ( IMPACT-III scale ) ( p = @ ) .
8
175,655
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24954822
1conclusions
This is the first randomized controlled study to suggest improvements in depression severity , global functioning , quality of life , and disease activity in a physically ill pediatric cohort treated with psychotherapy .
9
175,656
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24954822
1conclusions
Clinical trial registration information-Reducing Depressive Symptoms in Physically Ill Youth ; http://clinical trials.gov ; NCT@ .
10
175,657
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24950708
0background
The HIV/AIDS epidemic continues to disproportionately affect African American communities in the US , particularly those located in urban areas .
0
175,658
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24950708
0background
Despite the fact that HIV is often transmitted from one sexual partner to another , most HIV prevention interventions have focused only on individuals , rather than couples .
1
175,659
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24950708
0background
This five-year study investigates community-based implementation , effectiveness , and sustainability of ` Eban II , ' an evidence-based risk reduction intervention for African-American heterosexual , serodiscordant couples .
2
175,660
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24950708
2methods
This hybrid implementation/effectiveness implementation study is guided by organizational change theory as conceptualized in the Texas Christian University Program Change Model ( PCM ) , a model of phased organizational change from exposure to adoption , implementation , and sustainability .
3
175,661
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24950708
2methods
The primary implementation aims are to assist @ community-based organizations ( CBOs ) to implement and sustain Eban II ; specifically , to partner with CBOs to expose providers to the intervention ; facilitate its adoption , implementation and sustainment ; and to evaluate processes and determinants of implementation , effectiveness , fidelity , and sustainment .
4
175,662
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24950708
2methods
The primary effectiveness aim is to evaluate the effect of Eban II on participant ( n = @ couples ) outcomes , specifically incidents of protected sex and proportion of condom use .
5
175,663
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24950708
2methods
We will also determine the cost-effectiveness of implementation , as measured by implementation costs and potential cost savings .
6
175,664
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24950708
2methods
A mixed methods evaluation will examine implementation at the agency level ; staff members from the CBOs will complete baseline measures of organizational context and climate , while key stakeholders will be interviewed periodically throughout implementation .
7
175,665
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24950708
2methods
Effectiveness of Eban II will be assessed using a randomized delayed enrollment ( waitlist ) control design to evaluate the impact of treatment on outcomes at posttest and three-month follow-up .
8
175,666
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24950708
2methods
Multi-level hierarchical modeling with a multi-level nested structure will be used to evaluate the effects of agency - and couples-level characteristics on couples-level outcomes ( e.g. , condom use ) .
9
175,667
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24950708
1conclusions
This study will produce important information regarding the value of the Eban II program and a theory-guided implementation process and tools designed for use in implementing Eban II and other evidence-based programs in demographically diverse , resource-constrained treatment settings .
10
175,668
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24675203
0background
The incidence of community-acquired methicillin-resistant Staphylococcus aureus infections is rising at an alarming pace .
0
175,669
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24675203
0background
Effective treatment has historically involved early dbridement and antibiotic administration .
1
175,670
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24675203
0background
This study was designed to prospectively determine the effectiveness of empiric therapy in treating hand infections .
2
175,671
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24675203
2methods
A prospective randomized trial was conducted at a level I county hospital .
3
175,672
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24675203
2methods
Patients with a hand infection received either empiric intravenous vancomycin at admission or intravenous cefazolin .
4
175,673
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24675203
2methods
Outcomes were tracked using severity of infection , appropriate clinical response , and length of stay .
5
175,674
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24675203
2methods
Cost-effectiveness was calculated using total cost for each patient in both groups .
6
175,675
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24675203
2methods
Statistical analyses were performed .
7
175,676
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24675203
4results
Forty-six patients were enrolled in the study .
8
175,677
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24675203
4results
Twenty-four were randomized to cefazolin ( @ percent ) and @ ( @ percent ) to vancomycin .
9
175,678
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24675203
4results
There was no statistical difference between cost of treatment ( p < @ ) or mean length of stay ( p < @ ) between the groups .
10
175,679
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24675203
4results
Patients randomized to cefazolin had higher mean costs of treatment compared with patients who were randomized to vancomycin ( p < @ ) .
11
175,680
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24675203
4results
Patients with more severe infections had more expensive mean costs of treatment ( p < @ ) and longer mean length of stay ( p = @ ) .
12
175,681
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24675203
4results
Near the end of the study , the incidence of community-acquired methicillin-resistant S. aureus at the authors ' county hospital was discovered to be @ percent , which caused the study to be terminated prematurely by the institutional review board because of the high incidence precluding further randomization .
13
175,682
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24675203
1conclusions
Appropriate early treatment for methicillin-resistant S. aureus has not been definitively established .
14
175,683
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24675203
1conclusions
No difference in outcome using cefazolin versus vancomycin as a first-line agent was identified .
15
175,684
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24991733
0background
Deficient nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction ( HFpEF ) and pulmonary hypertension ( PH ) .
0
175,685
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24991733
0background
The acute hemodynamic effects of riociguat , a novel soluble guanylate cyclase stimulator , were characterized in patients with PH and HFpEF .
1
175,686
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24991733
2methods
Clinically stable patients receiving standard HF therapy with a left ventricular ejection fraction > @ % , mean pulmonary artery pressure ( mPAP ) @ mm Hg , and pulmonary arterial wedge pressure ( PAWP ) > @ mm Hg at rest were randomized to single oral doses of placebo or riociguat ( @ , @ , or @ mg ) .
2
175,687
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24991733
2methods
The primary efficacy variable was the peak decrease in mPAP from baseline up to @ h. Secondary outcomes included hemodynamic and echocardiographic parameters , safety , and pharmacokinetics .
3
175,688
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24991733
4results
There was no significant change in peak decrease in mPAP with riociguat @ mg ( n = @ ) vs placebo ( n = @ , P = @ ) .
4
175,689
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24991733
4results
However , riociguat @ mg significantly increased stroke volume ( +@ mL -LSB- @ % CI , @-@ -RSB- ; P = @ ) and decreased systolic BP ( -@ mm Hg -LSB- @ % CI , -@ to -@ -RSB- ; P = @ ) and right ventricular end-diastolic area ( -@ cm@ -LSB- @ % CI , -@ to -@ -RSB- ; P = @ ) , without significantly changing heart rate , PAWP , transpulmonary pressure gradient , or pulmonary vascular resistance .
5
175,690
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24991733
4results
Riociguat was well tolerated .
6
175,691
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24991733
1conclusions
In patients with HFpEF and PH , riociguat was well tolerated , had no significant effect on mPAP , and improved exploratory hemodynamic and echocardiographic parameters .
7
175,692
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25409287
3objective
Posttraumatic stress disorder ( PTSD ) is prevalent , persistent , and disabling .
0
175,693
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25409287
3objective
Although psychotherapy and pharmacotherapy have proven efficacious in randomized clinical trials , geographic barriers impede rural veterans from engaging in these evidence-based treatments .
1
175,694
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25409287
3objective
To test a telemedicine-based collaborative care model designed to improve engagement in evidence-based treatment of PTSD .
2
175,695
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25409287
2methods
The Telemedicine Outreach for PTSD ( TOP ) study used a pragmatic randomized effectiveness trial design with intention-to-treat analyses .
3
175,696
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25409287
2methods
Outpatients were recruited from @ Department of Veterans Affairs ( VA ) community-based outpatient clinics serving predominantly rural veterans .
4
175,697
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25409287
2methods
Inclusion required meeting diagnostic criteria for current PTSD according to the Clinician-Administered PTSD Scale .
5
175,698
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25409287
2methods
Exclusion criteria included receiving PTSD treatment at a VA medical center or a current diagnosis of schizophrenia , bipolar disorder , or substance dependence .
6
175,699
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