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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24805184
0background
Here , we validate a measure of cumulative viremia to evaluate HAART efficacy .
2
175,400
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24805184
2methods
We accessed HAART efficacy using data from a randomized clinical trial conducted in Mexico .
3
175,401
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24805184
2methods
We compared the proportion of individuals achieving a viral load < @ and < @ copies/mL at week @ , against the cumulative plasma viral load , estimated as the area under the plasma viral load curve ( AUVLC ) .
4
175,402
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24805184
2methods
High AUVLC indicates high cumulative viremia .
5
175,403
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24805184
1conclusions
There was a strong and significant association between the proportion of individuals achieving a viral load < @ and < @ copies/mL at week @ , with individuals suppressed having significant lower cumulative viremia .
6
175,404
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24805184
1conclusions
The median area was @ ( @th-@th percentile -LSB- Q@-Q@ -RSB- @-@ ) if viral load < @ copies/mL and @ ( Q@-Q@ @-@ ) if viral load @ copies/mL ( p-value @ ) .
7
175,405
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24805184
1conclusions
When the analysis was stratified by study arm , individuals on efavirenz had lower cumulative viremia than those on boosted lopinavir .
8
175,406
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24805184
1conclusions
Our findings suggest that cumulative viremia should be explored further as a tool to simultaneously evaluate the individual and public health efficacy of HAART .
9
175,407
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24805184
1conclusions
This is particularly relevant to the implementation and evaluation of the Treatment @ strategy recently proposed by UNAIDS and the WHO , as a means to maximize the individual and public health benefit of HAART .
10
175,408
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25230071
3objective
To determine whether differences could be detected in mobility outcomes during community mobility and home mobility tasks according to type of mobility assistive device .
0
175,409
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25230071
2methods
Randomized , repeated measures .
1
175,410
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25230071
2methods
Community mobility task : traversing @ m between the rehabilitation clinic and hospital entrance ; home mobility task : traversing @m into and out of a patient training bathroom and bedroom .
2
175,411
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25230071
2methods
Community-dwelling , cognitively intact ambulatory veterans ( N = @ ) who used a mobility device within the @ days prior to the study .
3
175,412
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25230071
2methods
Participants tested @ types of mobility assistive devices with wheels : @-wheeled walker ( WW ) , manual wheelchair ( MWC ) , and powered wheelchair ( PWC ) .
4
175,413
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25230071
2methods
The first and last devices used by each participant were randomly assigned as either MWC or WW .
5
175,414
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25230071
2methods
The PWC was always the second device .
6
175,415
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25230071
2methods
Speed ( m/s ) , collisions ( total ) , fatigue ( @-@ Likert scale ) , and pain ( @-@ Likert scale , diagram ) .
7
175,416
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25230071
4results
The community mobility task was performed with all @ devices by @ ( @ % ) veterans , and the home mobility task was performed with all @ devices by @ ( @ % ) participants .
8
175,417
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25230071
4results
In each task , @ participants used the WW and @ participants used the MWC as the final device .
9
175,418
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25230071
4results
In the community mobility task , statistically significant differences ( P < @ ) were seen with @ device comparison for all studied outcomes ( eg , standardized mean difference for the MWC compared with the PWC showed -@ fewer collisions for the MWC ) .
10
175,419
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25230071
4results
In the home mobility task , speed , collisions , and fatigue showed statistically significant ( P < @ ) device-related differences ( eg , standardized mean difference for the WW compared with the MWC showed -@ fewer collisions for the WW ) .
11
175,420
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25230071
1conclusions
We found statistically significant and substantively different effects from @ commonly used mobility assistive devices with wheels on diverse mobility outcomes when used in typical community mobility and home mobility tasks , providing proof of concept support for a research methodology applicable to comparative outcome studies of diverse mobility aids .
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175,421
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24707675
0background
Ramadan fasting is a special model of hunger and particularly affects metabolic processes , including carbohydrate and lipid levels .
0
175,422
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24707675
0background
Endocrine changes induced by Ramadan fasting are not well known .
1
175,423
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24707675
3objective
The aim of this article was to evaluate the changes in hormone levels in women before and after the special Muslim fasting period of Ramadan .
2
175,424
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24707675
2methods
This study was performed in @ healthy women in Obstetrics and Gynecology department during the Ramadan month of@ .
3
175,425
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24707675
2methods
Patients during and after the first menstrual period had menstrual cycles fasting blood samples taken on the same days .
4
175,426
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24707675
2methods
Luteinizing hormone ( LH ) , follicle stimulating hormone ( FSH ) , estradiol ( E@ ) , testosterone , and prolactin ( PRL ) levels were determined .
5
175,427
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24707675
4results
Before and during fasting LH , FSH , E@ , testosterone and PRL levels were not statistically different .
6
175,428
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24707675
1conclusions
Despite the limited available studies on these subjects in women , effect of Ramadan fasting on hormone levels were found to be within the normal limits .
7
175,429
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25487932
3objective
This work intended to observe the effect of injecting botolinum toxin type A ( BTX-A ) for relieving spastic iliopsoas of cerebral palsy on children , and to investigate the improvement of this method for the motor function in these children .
0
175,430
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25487932
2methods
From July @ to August @ , @ children with spastic iliopsoas cerebral palsy were received rehabilitation therapy .
1
175,431
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25487932
2methods
The age ranged from @ to @ years .
2
175,432
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25487932
2methods
The control group were treated by conventional physical therapy ( PY ) .
3
175,433
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25487932
2methods
The experimental group were treated not only by the conventional physical therapy , but also BTX-A injection .
4
175,434
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25487932
2methods
The dose of BTX-A injection was according to the weight of the child and the Modified Ashworth Scale ( MAS ) .
5
175,435
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25487932
2methods
The dose of the injection ranged from @ IU to @ IU with the average dose @ IU .
6
175,436
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25487932
4results
There was no significant difference between two the groups on ages , weight and MAS , GMFM ( Gross Motor Function Measure ) and extension angle of hip joints before treatment .
7
175,437
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25487932
4results
In both groups , the Modified Ashworth Scale decreased , GMFM and extension angle of hip joints increased after eight weeks .
8
175,438
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25487932
4results
In the control group , the GMFM improved significantly .
9
175,439
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25487932
4results
In the experimental group , MAS , GMFM and extension angle of hip joints changed significantly after therapy .
10
175,440
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25487932
4results
There was significant difference between two groups in MAS , GMFM and extension angle of hip joints after two months .
11
175,441
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25487932
1conclusions
The BTX-A injection can relieve iliopsoas spasticity of cerebral palsy on children efficiently .
12
175,442
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25487932
1conclusions
This therapy can help children to correct abnormal gait and to improve their motor function .
13
175,443
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24954573
3objective
This study sought to assess radiation exposure and operator discomfort when using left radial approach ( LRA ) versus right radial approach ( RRA ) for coronary diagnostic and percutaneous interventions .
0
175,444
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24954573
0background
The transradial approach is increasingly being adopted as the preferred vascular access for coronary interventions .
1
175,445
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24954573
0background
Currently , most are performed using an RRA .
2
175,446
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24954573
0background
This is in part due to the perceived increased operator physical discomforts as well increased radiation exposure with an LRA .
3
175,447
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24954573
2methods
One hundred patients were randomized to an LRA or RRA .
4
175,448
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24954573
2methods
Each operator ( n = @ ) had an independent randomization process , and patients were stratified according to obesity status .
5
175,449
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24954573
2methods
Operator radiation was measured using separate sets of radiation dosimeter badges placed externally on the head and thyroid and internally on the sternum .
6
175,450
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24954573
2methods
Operator physical discomfort was surveyed at @ time points : during vascular access and at the end of the procedure .
7
175,451
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24954573
2methods
Moderate to severe physical discomfort was defined as a score of > @ .
8
175,452
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24954573
4results
There were no significant differences in baseline and procedural variables between groups .
9
175,453
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24954573
4results
There was a significant increase in external radiation exposure using the RRA versus LRA ( head : median : @ -LSB- interquartile range ( IQR ) : @ to @ -RSB- mRems vs. median : @ -LSB- IQR : @ to @ -RSB- mRems , p = @ ; thyroid : median : @ -LSB- IQR : @ to @ -RSB- mRems vs. median : @ -LSB- IQR : @ to @ -RSB- mRems , p = @ ) .
10
175,454
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24954573
4results
More discomfort was reported with the LRA during access ( LRA : @ % vs. RRA : @ % ; p = @ ) , but not during the procedure ( LRA : @ % vs. RRA : @ % , p = @ ) .
11
175,455
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24954573
4results
This difference was almost entirely noted inobese patients ( LRA : @ % vs. RRA : @ % , p = @ ) .
12
175,456
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24954573
1conclusions
LRA is as effective as RRA , showing a safer profile with decreased radiation exposure to the operator , at the expense of more operator discomfort only during vascular access and limited to obese patients .
13
175,457
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24712568
3objective
To determine dose-dependent effects of T administration on cardiovascular risk markers in women with low T levels .
0
175,458
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24712568
2methods
Seventy-one hysterectomized women with or without oophorectomy with total T < @ ng/dL and/or free T < @ pg/mL received a standardized transdermal estradiol regimen during the @-week run-in period and were then randomized to receive weekly im injections of placebo or @ - , @ - , @ - , or @-mg T enanthate for @ weeks .
1
175,459
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24712568
2methods
Total and free T levels were measured by liquid chromatography-tandem mass spectrometry and equilibrium dialysis , respectively .
2
175,460
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24712568
2methods
Insulin resistance and inflammatory markers were measured at baseline and @ weeks .
3
175,461
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24712568
2methods
In a subset of women , magnetic resonance imaging of the abdomen was performed to quantify abdominal fat volume .
4
175,462
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24712568
4results
Fifty-nine women who completed the @-week intervention were included in the final analysis .
5
175,463
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24712568
4results
The five groups were similar at baseline .
6
175,464
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24712568
4results
Mean on-treatment nadir total T concentrations were @ , @ , @ , @ , and @ ng/dL in the placebo group and the @ - , @ - , @ - , and @-mg groups , respectively .
7
175,465
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24712568
4results
No significant changes in fasting glucose , fasting insulin , homeostatic model assessment of insulin resistance , high sensitivity C-reactive protein , adiponectin , blood pressure , and heart rate were observed at any T dose when compared to placebo .
8
175,466
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24712568
4results
Similarly , no dose - or concentration-dependent changes were observed in abdominal fat on magnetic resonance imaging .
9
175,467
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24712568
1conclusions
Short-term T administration over a wide range of doses for @ weeks in women with low T levels was not associated with worsening of cardiovascular risk markers .
10
175,468
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24973281
0background
The phe@del CFTR mutation causes cystic fibrosis by limiting the amount of CFTR protein that reaches the epithelial cell surface .
0
175,469
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24973281
0background
We tested combination treatment with lumacaftor , an investigational CFTR corrector that increases trafficking of phe@del CFTR to the cell surface , and ivacaftor , a CFTR potentiator that enhances chloride transport of CFTR on the cell surface .
1
175,470
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24973281
2methods
In this phase @ clinical trial , we assessed three successive cohorts , with the results of each cohort informing dose selection for the subsequent cohort .
2
175,471
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24973281
2methods
We recruited patients from @ cystic fibrosis centres in Australia , Belgium , Germany , New Zealand , and the USA .
3
175,472
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24973281
2methods
Eligibility criteria were : confirmed diagnosis of cystic fibrosis , age at least @ years , and a forced expiratory volume in @ s ( FEV@ ) of @ % or more than predicted .
4
175,473
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24973281
2methods
Cohort @ included phe@del CFTR homozygous patients randomly assigned to either lumacaftor @ mg once per day for @ days followed by addition of ivacaftor @ mg or @ mg every @ h for @ days , or @ days of placebo .
5
175,474
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24973281
2methods
Together , cohorts @ and @ included phe@del CFTR homozygous and heterozygous patients , randomly assigned to either @ days of lumacaftor ( cohort @ : @ mg , @ mg , or @ mg once per day , cohort @ : @ mg every @ h ) with ivacaftor @ mg every @ h added after @ days , or @ days of placebo .
6
175,475
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24973281
2methods
The primary outcomes for all cohorts were change in sweat chloride concentration during the combination treatment period in the intention-to-treat population and safety ( laboratory measurements and adverse events ) .
7
175,476
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24973281
2methods
The study is registered with ClinicalTrials.gov , number NCT@ , and EudraCT , number @-@-@ .
8
175,477
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24973281
4results
Cohort @ included @ participants .
9
175,478
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24973281
4results
Cohort @ and @ combined contained @ phe@del CFTR homozygous patients and @ compound heterozygotes .
10
175,479
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24973281
4results
Treatment with lumacaftor @ mg once daily and ivacaftor @ mg every @ h decreased mean sweat chloride concentration by @ mmol/L ( p < @ ) during the combination treatment period in cohort @ .
11
175,480
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24973281
4results
In cohorts @ and @ , mean sweat chloride concentration did not decrease significantly during combination treatment in any group .
12
175,481
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24973281
4results
Frequency and nature of adverse events were much the same in the treatment and placebo groups during the combination treatment period ; the most commonly reported events were respiratory .
13
175,482
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24973281
4results
@ of @ participants had chest tightness or dyspnoea during treatment with lumacaftor alone .
14
175,483
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24973281
4results
In pre-planned secondary analyses , a significant decrease in sweat chloride concentration occurred in the treatment groups between day @ and day @ ( lumacaftor @ mg once per day group -@ mmol/L , p < @ ; lumacaftor @ mg once per day group -@ mmol/L , p < @ ; lumacaftor @ mg every @ h group -@ mmol/L , p = @ ) .
15
175,484
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24973281
4results
These changes were significantly greater than the change in the placebo group .
16
175,485
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24973281
4results
In cohort @ , the lumacaftor @ mg once per day significantly improved FEV@ from day @ to @ ( difference compared with placebo group : +@ percentage points , p = @ ) , primarily during the combination period .
17
175,486
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24973281
4results
In cohort @ , FEV@ did not change significantly across the entire study period compared with placebo ( difference +@ percentage points , p = @ ) , but did during the combination period ( difference +@ percentage points , p = @ ) .
18
175,487
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24973281
4results
Phe@del CFTR heterozygous patients did not have a significant improvement in FEV@ .
19
175,488
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24973281
1conclusions
We provide evidence that combination lumacaftor and ivacaftor improves FEV@ for patients with cystic fibrosis who are homozygous for phe@del CFTR , with a modest effect on sweat chloride concentration .
20
175,489
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24973281
1conclusions
These results support the further exploration of combination lumacaftor and ivacaftor as a treatment in this setting .
21
175,490
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24736628
3objective
The aim of this study was to assess the glucose-lowering and lipid-modifying effects , and safety profile of lobeglitazone , a novel peroxisome proliferator-activated receptor - agonist , compared to placebo as a monotherapy in patients with type @ diabetes .
0
175,491
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24736628
2methods
In this @-week , multicenter , randomized , double-blind , parallel-group , placebo controlled study , @ patients were randomly assigned ( a @ ratio ) to lobeglitazone @ mg ( n = @ ) or matching placebo ( n = @ ) orally once daily .
1
175,492
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24736628
2methods
The primary endpoint was the change in glycated hemoglobin ( HbA@c ) from baseline to the end of treatment .
2
175,493
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24736628
2methods
The secondary endpoints included various glycemic parameters , lipid parameters and safety profile ( ClinicalTrials.gov number NCT@ ) .
3
175,494
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24736628
4results
At @ weeks , a significant reduction in HbA@c was observed with lobeglitazone versus placebo ( -@ % vs @ % , mean difference -@ % , p < @ ) .
4
175,495
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24736628
4results
The goal of HbA@c < @ % was achieved significantly more in the lobeglitazone group compared to the placebo group ( @ % vs @ % , p < @ ) .
5
175,496
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24736628
4results
Markers of insulin resistance were also improved in the lobeglitazone group .
6
175,497
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24736628
4results
In addition , lobeglitazone treatment significantly improved triglycerides , high density lipoprotein cholesterol , small dense low density lipoprotein cholesterol , free fatty acid , and apolipoprotein-B/CIII compared to placebo ( p < @ , respectively ) .
7
175,498
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24736628
4results
More weight gain was observed in the lobeglitazone group than the placebo group ( @ kg vs - @ kg , mean difference @ kg , p < @ ) .
8
175,499
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