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| embedding_all-mpnet-base-v2
sequence | embedding_multi-qa-mpnet-base-dot-v1
sequence | embedding_all-MiniLM-L12-v2
sequence |
|---|---|---|---|---|---|---|---|
24736628 | 4results
| The safety profile was comparable between the two groups and lobeglitazone was well tolerated . | 9 | 175,500 | [
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24736628 | 1conclusions
| Lobeglitazone @ mg showed a favorable balance in the efficacy and safety profile . | 10 | 175,501 | [
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24736628 | 1conclusions
| The results support a potential role of lobeglitazone in treating type @ diabetes . | 11 | 175,502 | [
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25919263 | 0background
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25919263 | 0background
| This study examined whether pulsed electromagnetic field therapy could produce similar results in patients undergoing unilateral transverse rectus abdominis myocutaneous ( TRAM ) flap breast reconstruction , a significantly more complex and painful surgical procedure . | 1 | 175,504 | [
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25919263 | 2methods
| In this double-blind , placebo-controlled , randomized study , @ patients undergoing unilateral TRAM flap breast reconstruction received active or sham pulsed electromagnetic field therapy . | 2 | 175,505 | [
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] |
25919263 | 2methods
| Pain levels were measured by using a visual analogue scale ; narcotic use and wound exudate volume were recorded starting @ hour postoperatively . | 3 | 175,506 | [
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25919263 | 2methods
| Wound exudates were analyzed for interleukin-@ . | 4 | 175,507 | [
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] |
25919263 | 4results
| Mean visual analogue scale pain scores were @-fold higher in the sham cohort at @ hours and @-fold higher at @ hours ( p < @ ) , along with a concomitant @-fold increase in narcotic use in sham patients ( p < @ ) . | 5 | 175,508 | [
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] |
25919263 | 4results
| Wound exudate volume was @-fold higher in the sham cohort at @ hours ( p < @ ) , and mean interleukin-@ concentration in wound exudates of sham patients was @-fold higher at @ hours ( p < @ ) . | 6 | 175,509 | [
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25919263 | 1conclusions
| Pulsed electromagnetic field therapy significantly reduced postoperative pain , inflammation , and narcotic use following TRAM flap breast reconstruction , paralleling its effect in breast reduction patients . | 7 | 175,510 | [
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25919263 | 1conclusions
| Both studies also report a significant reduction of interleukin-@ in the wound exudate , supporting a mechanism involving a pulsed electromagnetic field effect on nitric oxide/cyclic guanosine monophosphate signaling , which modulates the body 's antiinflammatory pathways . | 8 | 175,511 | [
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25919263 | 1conclusions
| Adjunctive pulsed electromagnetic field therapy could impact the speed and quality of wound repair in many surgical procedures . | 9 | 175,512 | [
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25919263 | 2methods
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25160013 | 3objective
| The objective of this study was to investigate the hypouricemic effects of green tea extract ( GTE ) in healthy individuals . | 0 | 175,514 | [
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25160013 | 2methods
| This study comprised @-week control , @-week interventional , and @-week follow-up periods . | 1 | 175,515 | [
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25160013 | 2methods
| Participants were assigned randomly at the interventional period to consume GTE at @ ( GTE@ ) , @ ( GTE@ ) , or @ ( GTE@ ) g/d . | 2 | 175,516 | [
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] |
25160013 | 2methods
| Levels of serum uric acid ( SUA ) , uric acid clearance , and serum antioxidant power ( using trolox equivalent antioxidant capacity assay ) were measured at both ends of each study period . | 3 | 175,517 | [
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25160013 | 4results
| After @ weeks of consumption , the mean SUA level tended to decrease in all groups , with no statistical significance . | 5 | 175,519 | [
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25160013 | 4results
| Serum uric acid reduction was greatest in GTE@ ( from @ @ mg/dL to @ @ mg/dL , @ % ) . | 6 | 175,520 | [
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25160013 | 4results
| Uric acid clearance decreased significantly in GTE@ ( from @ @ mL/min per @ m to @ @ mL/min per @ m , @ % , P < @ ) and GTE@ ( from @ @ mL/min per @ m to @ @ mL/min per @ m , @ % , P < @ ) . | 7 | 175,521 | [
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25160013 | 4results
| Serum antioxidant capacity ( TEAC ) increased significantly in GTE@ ( from @ @ mg/mL to @ @ mg/mL , @ % , P < @ ) . | 8 | 175,522 | [
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] |
25160013 | 4results
| There was no significant change in creatinine clearance . | 9 | 175,523 | [
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25160013 | 4results
| Gastrointestinal adverse events were common , but usually mild , with no medical treatment required . | 10 | 175,524 | [
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25160013 | 1conclusions
| Green tea extract may modestly lower SUA level and decreases uric acid clearance . | 11 | 175,525 | [
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25160013 | 1conclusions
| Green tea extract also significantly elevated serum antioxidant capacity with a positive dosage effect . | 12 | 175,526 | [
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25160013 | 1conclusions
| The effect of GTE on SUA in healthy individuals was short term . | 13 | 175,527 | [
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25160013 | 1conclusions
| The effects of GTE on urate handling in patients with hyperuricemia or gout need to be determined . | 14 | 175,528 | [
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25613721 | 0background
| An intradermal ( ID ) trivalent split-virion influenza vaccine ( IIV@-ID ) ( Fluzone ( ) Intradermal , Sanofi Pasteur , Swiftwater , PA ) has been available in the US since the @/@ influenza season for adults aged @-@ years . | 0 | 175,529 | [
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25613721 | 0background
| This study examined whether adding a second B-lineage strain affects immunogenicity and safety . | 1 | 175,530 | [
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25613721 | 2methods
| This randomized , double-blind , multicentre trial evaluated the immunogenicity and safety of an intradermal quadrivalent split-virion influenza vaccine ( IIV@-ID ) in adults @-@ years of age in the US during the @-@ influenza season . | 2 | 175,531 | [
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25613721 | 2methods
| Participants were randomized @:@:@ to receive a single injection of IIV@-ID , licensed IIV@-ID , or an investigational IIV@-ID containing the alternate B-lineage strain . | 3 | 175,532 | [
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25613721 | 2methods
| Haemagglutination inhibition antibody titres were assessed in two-thirds of participants before vaccination and @ days after vaccination . | 4 | 175,533 | [
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25613721 | 4results
| @ participants were vaccinated with IIV@-ID , @ with licensed IIV@-ID , and @ with an investigational IIV@-ID . | 5 | 175,534 | [
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] |
25613721 | 4results
| For all four vaccine strains , antibody responses to IIV@-ID were statistically non-inferior to the response to the IIV@-ID vaccines containing the matched strains . | 6 | 175,535 | [
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25613721 | 4results
| For both B strains , post-vaccination antibody responses to IIV@-ID were statistically superior to the responses to IIV@-ID lacking the corresponding B strain . | 7 | 175,536 | [
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25613721 | 4results
| Adverse events were similar for IIV@-ID and IIV@-ID . | 8 | 175,537 | [
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25613721 | 4results
| The most commonly reported solicited reactions were pain , pruritus , myalgia , headache , and malaise ; and most were grade @ or @ and appeared and resolved within @ days of vaccination . | 9 | 175,538 | [
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] |
25613721 | 4results
| IIV@-ID was statistically non-inferior to the two pooled IIV@-ID vaccines for the proportions of participants with at least one grade @ or @ systemic reaction . | 10 | 175,539 | [
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25613721 | 1conclusions
| Antibody responses to the IIV@-ID were non-inferior to IIV@-ID for the A and matched B strains and superior for the unmatched B strains . | 11 | 175,540 | [
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25613721 | 1conclusions
| IIV@-ID was well tolerated without any safety concerns . | 12 | 175,541 | [
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25613721 | 1conclusions
| IIV@-ID may help address an unmet need due to mismatched B strains in previous influenza vaccines . | 13 | 175,542 | [
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25270275 | 0background
| However , the benefits and harms of different hemoglobin thresholds for transfusion have not been established . | 1 | 175,544 | [
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25270275 | 2methods
| In this multicenter , parallel-group trial , we randomly assigned patients in the intensive care unit ( ICU ) who had septic shock and a hemoglobin concentration of @ g per deciliter or less to receive @ unit of leukoreduced red cells when the hemoglobin level was @ g per deciliter or less ( lower threshold ) or when the level was @ g per deciliter or less ( higher threshold ) during the ICU stay . | 2 | 175,545 | [
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] |
25270275 | 2methods
| The primary outcome measure was death by @ days after randomization . | 3 | 175,546 | [
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25270275 | 4results
| We analyzed data from @ of @ patients ( @ % ) who underwent randomization . | 4 | 175,547 | [
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] |
25270275 | 4results
| The two intervention groups had similar baseline characteristics . | 5 | 175,548 | [
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25270275 | 4results
| In the ICU , the lower-threshold group received a median of @ unit of blood ( interquartile range , @ to @ ) and the higher-threshold group received a median of @ units ( interquartile range , @ to @ ) . | 6 | 175,549 | [
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] |
25270275 | 4results
| At @ days after randomization , @ of @ patients ( @ % ) assigned to the lower-threshold group , as compared with @ of @ ( @ % ) assigned to the higher-threshold group , had died ( relative risk , @ ; @ % confidence interval , @ to @ ; P = @ ) . | 7 | 175,550 | [
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25270275 | 4results
| The results were similar in analyses adjusted for risk factors at baseline and in analyses of the per-protocol populations . | 8 | 175,551 | [
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] |
25270275 | 4results
| The numbers of patients who had ischemic events , who had severe adverse reactions , and who required life support were similar in the two intervention groups . | 9 | 175,552 | [
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25270275 | 1conclusions
| Among patients with septic shock , mortality at @ days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion at a lower threshold ; the latter group received fewer transfusions . | 10 | 175,553 | [
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25270275 | 1conclusions
| ( Funded by the Danish Strategic Research Council and others ; TRISS ClinicalTrials.gov number , NCT@ . ) | 11 | 175,554 | [
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26022813 | 0background
| It is uncertain whether triglycerides predict risk after ACS on a background of statin treatment . | 1 | 175,556 | [
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26022813 | 3objective
| This study examined the relationship of fasting triglyceride levels to outcomes after ACS in patients treated with statins . | 2 | 175,557 | [
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26022813 | 2methods
| Long-term and short-term relationships of triglycerides to risk after ACS were examined in the dal-OUTCOMES trial and atorvastatin arm of the MIRACL ( Myocardial Ischemia Reduction with Acute Cholesterol Lowering ) trial , respectively . | 3 | 175,558 | [
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26022813 | 2methods
| Analysis of dal-OUTCOMES included @,@ patients ( @ % statin-treated ) randomly assigned @ to @ weeks after ACS to treatment with dalcetrapib ( a cholesteryl ester transfer protein inhibitor ) or placebo and followed for a median @ months . | 4 | 175,559 | [
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] |
26022813 | 2methods
| Analysis of MIRACL included @,@ patients treated with atorvastatin @ mg daily beginning @ to @ days after ACS and followed for @ weeks . | 5 | 175,560 | [
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26022813 | 2methods
| Fasting triglycerides at initial random assignment were related to risk of coronary heart disease death , nonfatal myocardial infarction , stroke , and unstable angina in models adjusted for age , sex , hypertension , smoking , diabetes , high-density lipoprotein cholesterol , and body mass index . | 6 | 175,561 | [
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26022813 | 4results
| Fasting triglyceride levels were associated with both long-term and short-term risk after ACS . | 7 | 175,562 | [
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] |
26022813 | 4results
| In dal-OUTCOMES , long-term risk increased across quintiles of baseline triglycerides ( p < @ ) . | 8 | 175,563 | [
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] |
26022813 | 4results
| The hazard ratio in the highest/lowest quintile ( > @/@ mg/dl ) was @ ( @ % confidence interval : @ to @ ) . | 9 | 175,564 | [
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] |
26022813 | 4results
| There was no interaction of triglycerides and treatment assignment on the primary outcome . | 10 | 175,565 | [
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] |
26022813 | 4results
| In the atorvastatin group of MIRACL , short-term risk increased across tertiles of baseline triglycerides ( p = @ ) , with a hazard ratio of @ -LSB- corrected -RSB- ( @ % confidence interval : @ to @ ) in highest/lowest tertiles ( > @/@ mg/dl ) . | 11 | 175,566 | [
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26022813 | 4results
| The relationship of triglycerides to risk was independent of low-density lipoprotein cholesterol in both studies . | 12 | 175,567 | [
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26022813 | 1conclusions
| Among patients with ACS treated effectively with statins , fasting triglycerides predict long-term and short-term cardiovascular risk . | 13 | 175,568 | [
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26022813 | 1conclusions
| Triglyceride-rich lipoproteins may be an important additional target for therapy . | 14 | 175,569 | [
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26022813 | 1conclusions
| ( A Study of RO@ in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome ; NCT@ ) . | 15 | 175,570 | [
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25467560 | 0background
| In a phase @ study we aimed to assess the efficacy and safety of grazoprevir ( MK-@ ; HCV NS@/@A protease inhibitor ) and two doses of elbasvir ( MK-@ ; HCV NS@A inhibitor ) in patients with HCV mono-infection and HIV/HCV co-infection . | 1 | 175,572 | [
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25467560 | 2methods
| The C-WORTHY study is a phase @ , multicentre , randomised controlled trial of grazoprevir plus elbasvir with or without ribavirin in patients with HCV ; here , we report findings for previously untreated ( genotype @ ) patients without cirrhosis who were HCV mono-infected or HIV/HCV co-infected . | 2 | 175,573 | [
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25467560 | 2methods
| Eligible patients were previously untreated adults aged @ years or older with chronic HCV genoype @ infection and HCV RNA at least @ IU/mL in peripheral blood without evidence of cirrhosis , hepatocellular carcinoma , or decompensated liver disease . | 3 | 175,574 | [
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25467560 | 2methods
| In part A of the study we randomly assigned HCV-mono-infected patients to receive @ weeks of grazoprevir ( @ mg ) plus elbasvir ( @ mg or @ mg ) with or without ribavirin ( arms A@-@ ) ; in part B we assigned HCV-mono-infected patients to @ or @ weeks of grazoprevir ( @ mg ) plus elbasvir ( @ mg ) with or without ribavirin ( arms B@-@ ) and HIV/HCV co-infected patients to @ weeks of therapy with or without ribavirin . | 4 | 175,575 | [
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] |
25467560 | 2methods
| The primary endpoint was the proportion of patients achieving HCV RNA less than @ IU/mL @ weeks after end of treatment ( SVR@ ) . | 5 | 175,576 | [
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25467560 | 2methods
| Randomisation was by presence or absence of ribavirin , @ or @ weeks of treatment , and dosage of elbasvir . | 6 | 175,577 | [
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] |
25467560 | 2methods
| Patients were stratified by gentoype @a versus @b . | 7 | 175,578 | [
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25467560 | 2methods
| The patients , investigators , and study site personnel were masked to treatment group assignements but the funder was not . | 8 | 175,579 | [
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25467560 | 2methods
| Analysis was by intention to treat . | 9 | 175,580 | [
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25467560 | 2methods
| This trial is registered at ClinicalTrials.gov , number NCT@ . | 10 | 175,581 | [
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25467560 | 4results
| @ patients with HCV mono-infection ( n = @ ) and HIV/HCV co-infection ( n = @ ) were enrolled . | 11 | 175,582 | [
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25467560 | 4results
| SVR@ for patients treated for @ weeks with or without ribavirin ranged from @-@ % in mono-infected and @-@ % in co-infected patients . | 12 | 175,583 | [
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25467560 | 4results
| SVR@ rates in mono-infected and co-infected patients treated for @ weeks without ribavirin were @ % ( @ % CI @-@ ; @/@ ) and @ % ( @ % CI @-@ ; @/@ ) , respectively , and with ribavirin were @ % ( @ % CI @-@ ; @/@ ) and @ % ( @ % CI @-@ ; @/@ ) , respectively . | 13 | 175,584 | [
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25467560 | 4results
| Among mono-infected patients with genotype @a infection treated for @ weeks , SVR@ was @ % ( @ % CI @-@ ; @/@ ) . | 14 | 175,585 | [
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] |
25467560 | 4results
| Five of six patients who discontinued early for reasons other than virological failure had HCV RNA less than @ IU/mL at their last study visit . | 15 | 175,586 | [
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25467560 | 4results
| Virological failure among patients treated for @ weeks occurred in seven patients ( @/@ , @ % ) and was associated with emergence of resistance-associated variants to one or both drugs . | 16 | 175,587 | [
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25467560 | 4results
| The safety profile of grazoprevir plus elbasvir with or without ribavirin was similar in mono-infected and co-infected patients . | 17 | 175,588 | [
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25467560 | 4results
| No patient discontinued due to an adverse event or laboratory abnormality . | 18 | 175,589 | [
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25467560 | 4results
| The most common adverse events were fatigue ( @ patients , @ % ) , headache ( @ , @ % ) , nausea ( @ , @ % ) , and diarrhoea ( @ , @ % ) . | 19 | 175,590 | [
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25467560 | 1conclusions
| Once-daily grazoprevir plus elbasvir with or without ribavirin for @ weeks in previously untreated HCV-mono-infected and HIV/HCV-co-infected patients without cirrhosis achieved SVR@ rates of @-@ % . | 20 | 175,591 | [
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25467560 | 1conclusions
| These results support the ongoing phase @ development of grazoprevir plus elbasvir . | 21 | 175,592 | [
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24371021 | 0background
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24371021 | 0background
| The study was conducted to confirm the clinically effective and safe dose of methylphenidate hydrochloride modified-release ( MPH-LA ) in adults with ADHD and evaluate the maintenance of effect of MPH-LA . | 1 | 175,594 | [
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24371021 | 2methods
| The study consisted of three treatment phases . | 2 | 175,595 | [
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24371021 | 2methods
| The double-blind dose-confirmation phase : @-week double-blind period ( @-week titration period , @-week fixed dose ) with randomization to MPH-LA @ , @ , or @mg/day or placebo . | 3 | 175,596 | [
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24371021 | 2methods
| The real-life dose-optimization phase : a @-week re-titration period to optimal dose ; and the double-blind maintenance of effect phase , a @-month double-blind randomized placebo-controlled maintenance of effect phase . | 4 | 175,597 | [
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24371021 | 2methods
| The three co-primary endpoints were change in Diagnostic and Statistical Manual of Mental Disorders-IV ADHD Rating Scale ( DSM-IV ADHD RS ) and Sheehan Disability Scale ( SDS ) total scores from baseline to end of @-week confirmation phase and the percentage of treatment failures during the @-month maintenance of effect phase . | 5 | 175,598 | [
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24371021 | 4results
| @ of @ screened patients were randomized to @ ( N = @ ) , @ ( N = @ ) , or @mg ( N = @ ) MPH-LA or placebo ( N = @ ) , and @ ( @ % ) completed . | 6 | 175,599 | [
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