Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy
NCT Number: NCT06584695
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Analgesic Efficacy|External Oblique Intercostal Block|Subcostal Transversus Abdominis Plane Block|Open|Nephrectomy
Interventions: DRUG: Transversus abdominis plane block|DRUG: External Oblique Intercostal Plane Block|DRUG: Control group
Sponsor: Cairo University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 63
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-09-10
Completion Date: 2025-02-01
Locations: Cairo University, Cairo, 11796, Egypt

Summary:
To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative analgesia in cancer patients undergoing open nephrectomy.

Primary Outcome Measures: Degree of pain, Degree of pain by Numerical rating scale (NRS)score. NRS (0 pain represents "no pain" while 10 pain represents "the worst pain imaginable"). scores will be registered at rest and movement immediately after surgery and at two, six, 12 and 24 hours after surgery, when the (NRS) was \> 4, IV morphine PCA will be initiated with continuous rate of 1 mg/hr, a patient demand bolus of 1mg and with lockout time of 10 minutes based on the patient weight and gender. the first time to the rescue analgesia needed and the top up doses will be recorded., 24 hours after surgery
Secondary Outcome Measures: Mean arterial pressure, Mean arterial pressure will be recorded intraoperative till the end of surgery., Till the end of surgery (up to 2hours)|Heart rate, Heart rate will be recorded intraoperative till the end of surgery., Till the end of surgery (up to 2hours)|Opioids consumption, Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 pain represents "no pain" while 10 pain represents "the worst pain imaginable"). when the (NRS) was \> 4, IV morphine PCA will be initiated with continuous rate of 1 mg/hr, a patient demand bolus of 1mg and with lockout time of 10 minutes based on the patient weight and gender. the first time to the rescue analgesia needed and the top up doses will be recorded., 24 hours after surgery|Morphine consumption, When the numeric rating scale (NRS) was \>4, IV morphine PCA will be initiated with continuous rate of 1 mg/hr, a patient demand bolus of 1mg and with lockout time of 10 minutes based on the patient weight and gender. the first time to the rescue analgesia needed and the top up doses will be recorded.

Each patient will be instructed about postoperative pain assessment with the NRS score. NRS (0 pain represents "no pain" while 10 pain represents "the worst pain imaginable").NRS will be registered at rest and movement immediately after surgery and at two, six, 12 and 24 hours after surgery., 24 hours after surgery.|Time to rescue analgesia., Time to rescue analgesia will be recorded from the end of surgery till first dose of morphine administrated., 24 hours after surgery|Incidence of complications, Incidence of complications will be recorded such as pneumothorax, local anesthetic systemic toxicity (LAST), bradycardia, hypotension, nausea, vomiting, respiratory depression, or any other complication, 24 hours after surgery