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The was no significant difference in historical surgery, clinical features and paraclinical features between laparoscopic and conversion groups. |
The efficacy of platelet - rich plasma therapy in treatment of primary knee osteoarthritis after 6 months |
Three ethanol extracts (GL, GMQT, GMVP) were extracted from Gnetum latifolium var. |
funiculare Markgr. |
collected in Tay Nguyen province, Gnetum montanum Markgr collected in Quang Tri and Vinh Phuc province. |
Investigating their biological activity showed that all of them can inhibit enzyme xanthine oxidase and anti-inflammatory through the inhibition of NO prodution. |
Of these, the inhibition of NO prodution of three extracts are very good, especially the GMVP extract with IC50 21.33 ± 2.01µg / mL. |
The inhibition of the enzyme xanthine oxidase of GL extract gave the best result with IC50 66.01 ± 3.63µg / mL. |
Detection of a novel mutation on the gene ESCO2 in a pediatric patient with syndactyly |
We conducted the study to evaluate the efficacy and the safety of autologous platelet - rich plasma (RPR) therapy in the treatment of primary knee osteoarthritis. |
The autologous platelet - rich plasma therapy initially shows clinical improvement, degenerated knee joint repairment and the therapy is safe. |
45 patients with 63 osteoarthritis knee joints in grade II and III according to Kellgren and Lawrence classification. |
An intervention study was applied. |
Patients received 2 intra-articular injections of PRP (using Tricell kit) at 4-week intervals. |
After 6 months of treatment, the mean VAS score decreased from 6.06 ± 0.89 to 3.39 ± 1.93; WOMAC score decreased from 47.42 ± 8.02 to 12.19 ± 17.39 with p < 0.05. |
The average thickness of the knee joint cartilage on ultrasound has improved from 2.14 ± 0.32 mm to 2.39 ± 0.39 mm (p < 0.05). |
The rate of knee joint effusion decreased from 55.6% to 17.5%. |
17.5% of cases had increasing pain in the knee postinjection within 24 - 36 hours. |
No cases had joint infection or bleeding. |
Single incision laparoscopic duodeno-duodenostomy for congenital duodenal obstruction |
Syndactyly is a congenital disease caused by the limb formation abnormalities during fetal development. |
In this research, we studied the genetic mutations in a pediatric patient with 3rd and 4th fingers were fused together, symmetrically using the whole exome sequencing techniques based on Next generation sequencing. |
The obtained data revealed a novel mutation located in exon 11 of the gene ESCO2: c.1745A>G: p.582K>R. |
In silico prediction using PredictSNP, PhD-SNP, PROVEAN or Polyphen-2 tools indicated that the mutation was likely to affect the structure and function of Acetyltransferase? (encoded by ESCO2 gene). |
Further studies will be performed to analyze the effect of this mutations on the intracellular protein network associated with syndactyly. |
Clinical-pharmacological treatments for diabetes update |
We present our techniques of single incision laparoscopic duodeno-duodenostomy in a child with congenital duodenal obstruction (CDO). |
There was no significant blood loss, no intra - and post - operative complications. |
The operative duration was 130 minutes. |
At a follow up 9 months the girl was asymptomatic; she was able to eat solid food and gained weight well. |
The postoperative cosmesis was excellent as the patient had no visible scar. |
Conclusions: Our technique of single incision laparoscopic duodeno-duodenostomy for CDO can be feasible, safe with excellent postoperative cosmesis. |
Methods: This is a case report and review of the literature. |
Results: The patient was a 20 month-old girl, admitted to our department for multiple episodes of vomiting with onset very early in the newborn period, inability to eat solid food, malnutrition. |
Based on the clinical presentations and imaging studies, the diagnosis of CDO, probably due to duodenal atresia type I with fenestrated membrane, was made and the patient was indicated for laparoscopic surgical repair. |
A standard 5 mm, 300 laparoscope and conventional straight laparoscopic instruments were used. |
The distal duodenum was incised longitudinally and the proximal duodenum was incised obliquely. |
Beta lactamase isolated at Thai Nguyen central hospital 2018-2020 |
The aim of type 2 diabetes (T2DM) management is to provide personalized treatment to improve glucemia control efficacy in order to prevent complications and to reduce the side effects of glucoselowering agents. |
This efficacy is evaluated based on a clinical-pharmacological perspective through randomized controlled trials, meta-analyses and observational reallife studies, particularly in patient with high cardiovascular and renal risk. |
The benefitrisk balance of older antidiabetic agent, such as metformin sulfonylureas and glitazones, has been revisited. |
Updates of new glucoselowering medications have demonstrated not only cardiovascular safety but also cardiovascular and renal protection. |
The effectiveness and safety of new combinations and advances in insulin therapy are also discussed. |
Effect of drying temperature and drying methods on phytochemical contents and bioactivites of wild guava leaves (Psidium guajava L.) |
The study used a retrospective study method to evaluate antibiotic resistance of some extended spectrum beta-lactamase-producing gram-negative bacteria (ESBL) isolated at Thai Nguyen central hospital. 2018 - 2020. |
Research results: There were 388/1156 (33.5%) ESBL-producing Gram-negative bacteria strains isolated. |
Among 388 ESBL-producing strains, E coli had the highest ESBL-producing rate 307 (79.1%), K pneumoniae 58 (14.9%), Proteus sp 19 (4.9%). |
The ESBL (+) group of bacteria has a higher rate of antibiotic resistance than the ESBL (-) group, some Cephalosporins have a very high resistance rate such as E coli: Cefuroxime (90.9%), Ceftazidime (81.2%), Ceftriaxone (92.9%), Cefotaxime (95.7%) and Cefepime (76.4%), K peumoniae: Cefuroxime (75.7%), Cefotaxime (90.2%) Ceftriaxone (81, 6%), Ceftazidime (75%), Cefepime (62.1%), Proteus sp: Cefuroxime (100%), Cefotaxime (100%) Ceftriaxone (80%), Ceftazidime (75%). |
In addition, some antibiotics belonging to other antibiotic groups also have high resistance rates > 80% - 100% depending on the species of bacteria such as: Ampicillin, Tetracycline, Piperacillln, Trimethoprime - Sulfamethohazole. |
Determination of adenosine and cordycepin in dietary supplements circulating on the Hanoi market |
Psidium guajava L belongs to the Myrtaceae family and has been used as a medicinal plant to treat diarrhea and diabetes by local people in Dak Lak province. |
Recent publications showed that wild guava leaves possessed hypoglycemia activity in rat models. |
This study aimed to investigate the effects of drying methods including oven drying at different temperatures (50 °C, 60 °C, 70 °C, 80 °C) and traditional sun drying on the antioxidant, a-amylase and a-glucosidase inhibitory activities of wild guava leaves. |
The findings of this study showed that drying temperature has a significant impact on bioactive components as well as the biological activities of wild guava leaves. |
Amongst them, the sun drying method retained the TPC, TFC, TSC, antioxidant and enzyme inhibitory activities in leaves higher than drying at 70 °C, 80 °C. |
The results also indicated that oven drying at 50 °C was the most effective method for drying wild guava leaves in this study. |
A descriptive study of patients with lupus nephritis class V at Children’s hospital 2, Ho Chi Minh city |
High performance liquid chromatography with diode-array detector (HPLC-DAD) has been fully validated according to AOAC requirements for the determination of adenosine and cordycepin in dietary supplements containing Cordyceps. |
Chromatographic conditions using InertSustain C18 (250 mm × 4.6 mm; 5 µm) column, with gradient program composed of methanol and water eluted in 35 min, diode-array detector at 260 nm, flow rate of 1.0 mL / min. |
The study has determined the content of adenosine and cordycepin in 24 dietary supplement samples containing Cordyceps in different dosage forms circulating on the Hanoi market. |
The results showed that the contents of the two substances studied in the samples fluctuated greatly (adenosine from 28.19 - 956.3 µg / g with solid and oily form, from 1.26 - 25.31 µg / mL with the liquid form; cordycepin from 5.25 - 1287 µg / g with solid and oily form, from 1.91 - 32.38 µg / mL with liquid form), especially one sample was detected without both adenosine and cordycepin, one sample did not have adenosine. |
Postpartum depression and associated factors among mothers in O Cho Dua ward, Dong Da District, Ha Noi, 2016 |
The objectives of the paper are to document the rate of mother's postpartum depression and describe associated factors of postpartum depression. |
The descriptive and multivariate regression models were used for data analysis. |
Results showed that 30, 2% of mothers suffered from postpartum depression. |
There were 11 factors associated with mother's postpartum depression in bivariate analysis model. |
The study highlighted the need of sharing and support mothers. Besides, it is necessary to promote media programs to reduce the pressure on baby's gender among postpartum mothers. |
Admission blood glucose level and HbA1c and relationship with some parameters in acute stroke patients |
We conducted this study to evaluate the effectiveness of surgical by TLIF O-arm among patients with lumbar spondylolisthesis. |
We also evaluated the outcomes of radiographic imaging. |
Results: There were 47 patients with lumbar spondylolisthesis were recruited for the study. |
Nearly half of the study subjects have waist defects. |
The most common is spondylolisthesis on the L4L5 floor (33 patients, accounting for 70.2%), then on the L5S1 floor (16 patients, accounting for 34%). |
After surgery, VAS scores on the back and legs were lower than before surgery (p-value <0.05). |
Regarding the degree of slip assessed by X-ray, nearly 30 patients with grade 1 slipped before surgery, while grade 3 had the least number of patients at surgery (p-value <0.05). |
Conclusion: Our study has shown the effectiveness of surgery in pain relief. |
Outcomes of arterial switch operation for simple Taussig - Bing anomaly at Vietnam national children’s hospital |
To survey admission blood glucose level, HbA1c and relationship with some clinical and subclinical characteristics in acute stroke patients treated in Trung Vuong Hospital, Ho Chi Minh City. |
Conclusions: Increased blood glucose and HbA1c occurred in acute stroke patients with high rates, in which stress hyperglycemia did not depend on diabetes mellitus before stroke. |
Subjects and methods: The participants comprised 98 patients with acute stroke who were performed glucose and HbA1c tests at the time of admission. |
Increases in blood glucose level and HbA1c in stroke patients with or without diabetes mellitus was determined as glucose > 6 mmol / l; HbA1c ≥ 5.7%. |
Results: elevated blood glucose level and HbA1c accounted for high rates, 84.7% and 89.6%, respectively. |
Rate of alone or combined stress hyperglycemia was 20.4%. |
Female patients had higher rates of increased blood glucose and HbA1c than male patients. |
Blood glucose level had a significantly negative correlation with Glasgow Coma Scale. |
Rate of HbA1c ≥ 6.5% in patients with ischemic stroke was higher than that in those with hemorrhagic stroke. |
Rates of increased blood glucose and HbA1c were not significantly associated with previous diabetes diagnosis. |
Antihypertensive real treatment in hypertensive outpatients according to 2018 esc/esh guidelines |
Outcomes ofarterial switch operation for simple Taussig - Bing anomaly at Children Heart Center, Vietnam National Children's Hospital was evaluated. |
Methods: From January 2010 to December 2018, all patients diagnosed of simple Taussig - Bing anomaly (without aortic arch anomalies) who underwent arterial switch operation at our center was retrospective review. |
Results: There were 36 consecutive patients was enrolled to this study. |
The median age and the median weight at operation was 98 + 69 days [12 - 294], and 4.2 + 0.9 kg [2.8 - 6.7], respectively. |
Therewere 3 early death (8.3%) and 1 late death (2.8%) after arterial switch operation. |
The major complication was nosocomial infection. |
There were 2 patients required reoperation during a mean follow - up time of 47.5 + 33.9 months [1 - 102]: 1 patient with right ventricular outflow tract obstruction and 1 patient have sinus disfunction bradycardia required atrial pacemaker implantation. |
The Kaplan - Meier methods shown the overall survival was 89% at 1 year follow - up and steady maintain at the midterm follow - up. |
Conclusions: Outcomes of arterial switch operation for simple Taussig - Bing anomaly in Vietnam National Children's Hospital was satisfaction, and longer follow - up are essential. |
Assessment risk factors of anastomotic stricture following rectal cancer surgery at K hospital |
Conclusions: Approximately 4 out of 5 patients were prescribed with combination therapy. |
Fixed-dose combinations were used nearly half the population. |