Introducción: Identificar grupo etario con riesgo de Dengue Grave (DG) dentro del grupo de lactantes, podría evitar hospitalizaciones innecesarias. Objetivo: Determinar la incidencia de DG en lactantes hospitalizados durante la epidemia 2013. Materiales y Métodos: Diseño de cohorte retrospectivo, se incluyeron todos los niños menores de un año con Fiebre Dengue confirmado por serología. Resultados: De 60 lactantes, 82% fueron menores de 6 meses de edad. 15 (25%) evolucionaron a DG, 3 presentaron shock sin fuga capilar, uno fue diagnosticado de miocarditis y otro hepatitis. Los niños con DG tenían ≤ 6 meses (RR= 1.4 IC 1.2-1.4p = 0.02). Durante el seguimiento 34 (56,6%) desarrollaron signos de alarma, 15 clasificaron como DG, 19 (31,6%) fueron de alta como DSA. Ingresaron en fase febril (DG: 2.6 ±1.3 días versus DNG: 2.1±1.2 p: 0.14). La fuga capilar se produjo entre el día 4-5 de la enfermedad (media 4.6 DS ±0.7). Los niños con DG tuvieron más signos de shock temprano (66.7% versus 18.2% RR= 1.9 IC= 1.1-3.3 p <0.001) y algún signo de alarma (RR=1.8 IC 1.3-2.4 p < 0.001), más plaquetopenia en el día 5° (86.6% versus 33.3% RR= 1.7 IC= 1.2- 2.4 p < 0.001), niveles más elevados de transaminasas (33.3 % versus 2.2 % RR= 1.5 IC= 1-2.2 p = 0.006) e hipoalbuminemia (2.6 ±0.48 versus 3.6 ±0.49 p <0.001). Requirieron más bolos de cristaloides (100% versus 33.3% RR= 2 IC= 1.4-2.8 p <0.001), hidratación parenteral (93.3% versus 46.5% RR= 1.6 IC= 1.2 - 2.1 p= 0.001), soporte vasoactivo y transfusiones con hemoderivados. Conclusiones: Se observa tendencia de mayor riesgo de la enfermedad en menores con edad igual o menor a 6 meses.

Introduction: Identification of infant age groups at risk for severe dengue (SD) could avoid unnecessary hospital admissions. Objective: To determine the incidence of SD in infants hospitalized during the 2013 epidemic. Materials and Methods: We conducted a retrospective cohort study including all children under age 1 year with serologically-confirmed dengue fever. Results: Of 60 infants, 82% were under age 6 months: 15 (25%) developed SD, 3 presented shock with no capillary leakage, 1 was diagnosed with myocarditis, and 1 with hepatitis. Children with SD were aged ≤ 6 months (RR=1.4, CI 1.2-1.4, p=0.02). During follow up 34 (56.6%) developed alarm signs, 15 were classified as having SD, and 19 (31.6%) were discharged as having dengue with warning signs. Fever was reached in SD at 2.6 ±1.3 days, versus NSD at 2.1 ±1.2 days (p=0.14). Capillary leakage occurred at 4-5 days of illness in (mean SD: 4.6 ±0.7). Children with SD had more sign of early-onset shock (66.7% vs. 18.2%, RR: 1.9, CI 1.1-3.3, p<0.001), alarm sign (RR: 1.8, CI 1.3-2.4, p<0.001), thrombocytopenia at day 5 (86.6% vs. 33.3%, RR: 1.7, CI 1.2-2.4, p<0.001), and higher transaminase levels (33.3% vs. 2.2%, RR 1.5, CI 1-2.2, p=0.006) and hypoalbuminemia (2.6 ±0.48 vs. 3.6 ±0.49, p<0.001). They also more frequently required crystalloid boluses (100% vs. 33.3%, RR 2, CI 1.4-2.8, p<0.001), parenteral hydration (93.3% vs. 46.5%, RR 1.6, CI 1.2-2.1, p<0.001), vasoactive agents, and blood product transfusion. Conclusions: A tendency toward more risk of the disease was seen in infants aged ≤6 months.