Talk:Drosophila embryogenesis

message: I would like to add this information which includes a table, but I don't know how to do it and don't have the time for it right now:
Embryogenesis is commonly divided into 17 stages that are grouped into 7 common stages.(source: FlyMove, Volker Hartenstein and José Campos-Ortega )
Table:
Stage #, time (at 25 degrees C.. RT) onset, process, embryo stage
1-4,, 0-2:10hr, fertilization, cleavage, syncytial blastoderm
5,2:10-2:50, cellularization, cellular blastoderm
6,7, 2:50-3:10, gastrulation, gastrula
8-11, 3:10-7:20, germ band elongation, intercalation and cell shape change, ?
12-13, 7:20-10:20, germ band retraction
14-15, 10:20-13:00 Head involution and dorsal closure 
16-17, 13:00-22:00 Differentiation
Otherwise, I have some other ommissions that are listed here:
*How do we deal with segmentation (biology)? It probably should be a separate article. Morphogenesis has a lot of information on this, which maybe should be split out of that article into a separate article.
*Does drosophila have external fertilization? Is that relevant to it's usefullness as a model organism?
*Need to define a parasegment (or else direct to segmentation article)\
*Polytene chromosomes should be mentioned
*Would like to mention how to screen for developmental mutants.
AdamRetchless 00:04, 8 Apr 2004 (UTC)
thread_title: Untitled

message: This page is linked to from Drosophila_melanogaster#Development_and_embryogenesis. That section contains quite some information that is not here, even though this is supposed to be the "main article". It would be good to copy that information over.
Morphogenesis contains an extensive discussion on the a/p patterning system that might fit better on this page, since it's specific to Drosophila.
--131.243.56.64 02:14, 4 April 2006 (UTC)
thread_title:  related information spread over multiple pages 

message: For starters, define maternal effect and zygotic genes. The actual screening is rather complicated, and depends on whether you're looking for recessive, dominant, modifier, or suppressor mutations. Because of early work by Nüsslein-Volhard (and the hassle), I don't think many are doing screens for recessive maternal effect genes. Instead, they'd look for dominant modifiers or suppressors. I think this is probably beyond the scope of this article.  Kodoz (talk) 21:08, 6 May 2010 (UTC)
thread_title:  Developmental mutants 

message: The organization of this sectioning seems great in terms of transitioning from the top to bottom of the gene hierarchy. However, the majority of this section needs citations (along with other sections as well). (talk) 22:02, 8 May 2019 (UTC)
thread_title:  Anterior-posterior axis patterning in Drosophila 

message: That section is confusing enough to look incorrect. Briefly, there are 3 systems: torpedo-gurken, dorsal group genes, and the zygotic pathways (Twist, snail, all those things). Top/Grk acts in the follicle cells to establish the basic antero-dorsal layout of the embryo (ie, top mutants lack ventral features). Dorsal signaling is a maternal effect protein that acts in the embryo to establish the ventral-dorsal pattern. Twist and company layout the mesoderm and neurectoderm, and there are some complementary proteins that layout the dorsal features (you have them...dpp and zen). 
Top/grk are significant because of their homology to EGF/EGFR. Top/grk probably lays out the expression of pipe, nudel, and windbuetel in the vitelline membrane. In turn, these proteins activate a protease cascade that includes gd, snake, and easter in the perivitelline space. Easter cleaves spatzle, which is the ligand for Toll. Easter, spatzle, and Toll are not expressed in a localized manner, so it's their localized activation on the ventral side that introduces asymmetry to the embryo. Toll activates some signal transduction proteins (tube and pelle) in the cytoplasm, which ultimately dissociate the cactus-dorsal complex. Dorsal is a transcription factor and NFkB homolog; cactus is an iKB homolog. When freed from Cactus, Dorsal enters the nucleus. The actual pattern of Dorsal nuclear translocation is a ventral-dorsal gradient. High dorsal concentration in the nucleus leads to expression of mesoderm-proteins, low concentration leads to expression of amnioserosa proteins. Basically, Dorsal controls expression of zygotic D/V patterning genes. 
Couldn't tell you much about the zygotic genes: look into single minded, twist, snail, and rhomboid. 
One cool thing about drosophila D/V patterning is that it's the opposite of vertebrate D/V patterning. The default state for fruit flies is dorsal, but in xenopus, it's ventral. Easter-Spatzle-Toll set up a ventral Spemann organizer on the ventral side of the fly embryo. 
Kodoz (talk) 21:41, 6 May 2010 (UTC)
thread_title:  Dorsal-ventral pattern formation 

message: There has been a lot of recent work on morphogens that substantially challenges or revises the traditional view of factors such as Bicoid. The April, 2012 Cell commentary by Roth and Lynch provides an overview of these advances (). SpectraValor (talk) 14:09, 27 April 2012 (UTC)
thread_title:  Recent work on morphogens 

message: I find the sentences about research discoveries and nobel prizes in the middle of a section explaining the molecular and genetic aspects of embryogenesis to be distracting (ex: "Addition segmentation gene" section). I recommend sentences of those types that highlight important discoveries should either be done in the beginning of each section OR compile them all in a separate section. (talk) 22:02, 8 May 2019 (UTC)
thread_title:  Research history 

message: I recommend finding primary research articles on the topics and cite them instead of using mostly secondary sources like a textbook since those can possibly be out of date depending on the edition used. (talk) 22:02, 8 May 2019 (UTC)
thread_title:  References