Talk:Zoledronic acid

message: The article says:
Zoledronate is rapidly processed via the kidneys; consequently its administration is not recommended for patients with reduced renal function or kidney disease.
I'm sure this is true of almost any drugs, but some casual clicking around in Medline and elsewhere didn't turn up anything like this. For example, this article says
tell your doctor if you are being treated wtih radiation therapy and if you have or have ever had heart failure (condition in which the heart cannot pump enough blood to other parts of the body); anemia (condition in which red blood cells cannot bring enought oxygen to the other parts of the body); any condition that stops your blood from clotting normally; problems with your mouth, teeth, or gums; an infection, especially in your mouth; asthma, especially if it is made worse by aspirin; or kidney or liver disease
I'd think almost any drug might stress the kidneys and I'd think any patient ought to tell their doctor about kidney or liver disease before starting any significant course of drug treatment. The article seems to imply that zoledronate has a special risk, requiring a special caution. I have no reason to doubt this, but I'd like to see a citation. Dpbsmith (talk) 15:55, 1 April 2008 (UTC)
replies: text: Renal toxicity is an issue for all bisphosphonates as the non bone-binding drug is rapidly cleared by the kidneys. Thus they all have the standard warning regarding patients with compromised kidney function. Here is a citation for a ZA specific report that shows renal impairment in 23.8% of patients.
Oh WK, Proctor K, Nakabayashi M, Evan C, Tormey LK, Daskivich T, Antràs L, Smith M, Neary MP, Duh MS. The risk of renal impairment in hormone-refractory prostate cancer patients with bone metastases treated with zoledronic acid. Cancer. 2007 Mar 15;109(6):1090-6. PMID: 17311345 Dr Aaron (talk) 13:30, 2 April 2008 (UTC)
thread_title:  Kidney disease? 

message: There is talk of using this drug (and bisphosphonates in general) in the treatment of breast cancer. See: http://www.nytimes.com/2009/02/12/health/research/12bone.html  —Preceding unsigned comment added by 86.219.3.19 (talk) 09:29, 19 December 2009 (UTC)
replies: text: This is mentioned in the Research section. Rod57 (talk) 14:03, 4 May 2011 (UTC)
replies: text: A TED talk by David Agnus mentions this, and a TED talk by Mina Bissel suggests cancer is related to the extra cellular matrix or 'architecture' around the cell becoming damaged and failing to constrict its activity Timpo (talk) 12:53, 29 January 2014 (UTC)

text: thank you but TED talks are not OK sources under WP:MEDRS. Jytdog (talk) 13:50, 29 January 2014 (UTC)
thread_title:  Use in cancer therapy 

message: These links can be found in a number of recent articles in the review part, but I did not find for them the separate (secondary) review. If anyone knows of a secondary link, please give.
Intravenous administration of Zoledronic acid leads to the production of ApppI (a non-hydrolysable ATP analogue), which is cytotoxic, and  inhibits the mitochondrial adenine nucleotide translocase that leads to direct activation of mitochondrial apoptosisHannu Mönkkönen, Seppo Auriola, Petri Lehenkari et al., (2006 January 9). A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol.; 147(4): 437–445.       Dmitry Dzhagarov (talk) 09:11, 25 March 2016 (UTC)
thread_title: Need a secondary link

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thread_title:  External links modified 

message: We could have a History section for rough dates of pivotal trials, and dates of various FDA, EMA etc approvals. (Two FDA approvals seems to have been in August 2001, and March 2003) - Rod57 (talk) 15:50, 22 November 2017 (UTC)
thread_title:  A history section for dates