Talk:Trazodone

message: This page is a mess. Information is scattered everywhere and is not grouped together properly. For example, information about interactions is also under the precautions section. Sections 4, 5 and 6 also all belong in one large section with subdivisions. I'll clean it up eventually. Fuzzform 04:43, 11 May 2006 (UTC)
thread_title: note

message: The article currently states trazodone is a 5-HT2C antagonist, but this source (http://jpet.aspetjournals.org/content/285/3/983.abstract) explicitly says trazadone is a potent 5-HT2C agonist. The current reference on Wikipedia says the opposite. What gives? Can anyone with biomedical training and access to medical databases balance out the hypotheses about 5-HT2C interactions? 
From what can be gathered from the brazilian and american PI sheets (virtually identical),  some people experience a decrease in sex drive (which would be compatible with 5-HT2C agonism, if Wikipedia is to be trusted at all), while other, more rarely, experience an increase (which would be compatible with 5-HT2C antagonism.
This needs fixing! --Dnavarro (talk) 13:38, 5 March 2010 (UTC)
thread_title:  5-HT2C interactions 

message: Apparently this is a rare side effect that requires some sort of operation to correct, but it doesn't seem to be mentioned in this article. --Mista-X 21:30, 9 July 2007 (UTC)
replies: text: Indeed, it's mentioned on the paient information here "Some men have reported long-lasting and painful erections with trazodone hydrochloride.  If this happens to you, it is important that you stop taking trazodone hydrochloride and tell your doctor immediately."  from the patient info from a Winthrop packet, ref MPE 67991 --SirXaph 04:53, 3 November 2007 (UTC)
thread_title: Permanent Erection

message: From my psychopharmacology notes I have nefazodone and trazodone listed as SARIs = serotonergic antagonists and reuptake inhibitors. Is there more than that single citation to support the argument that they do not possess SRI activity? ("Trazodone is not a serotonin reuptake inhibitor"). If there is not significant corroboration, I will change this part to reflect controversy rather than simply stating it's not an SRI.--Xris0 (talk) 14:58, 1 May 2008 (UTC)
thread_title: mechanism of action - SRI?

message: That a Trazodone metabolite (mCPP at a miniscule percentage) is an SRI doesn't seem to me to qualify Trazodone as an SRI, nor does it to experts in this field.  Everyone around here (Wikipedia) likes quoting textbooks and op-ed articles.  Search JOURNAL ARTICLES and find out what laboratory studies of these drugs have uncovered.  Trazodone is, among other things, a 5HT-2A inhibitor at about 20 nM, making it, quite to the contrary, a good antidote to Serotonin Toxicity.  Mirtazapine, its fellow weakling as an anti-depressant, was used in the Netherlands to reverse ST on this very basis.   It takes not just run-of-the-mill overdoses, but rather mega doses of Trazodone to induce mild ST in rats (the symptoms in rats vary distinctly and in degree from those in humans).  Case studies here and in not-particularly-well-refereed journals keep being cited about drugs including triptans and 1A-mediators causing ST, and everyone keeps accepting these assertions by non-experts (usually ER doctors or non-experts in ST) without batting an eye, and we end up wondering why we get: "Wikipedia entries on the costliest medical conditions contradicted the latest medical research 90% of the time" in a study in 2014.    — Preceding unsigned comment added by Constantin Constantius (talk • contribs) 04:44, 25 May 2018 (UTC)
thread_title: Trazodone Not an SRI

message: "Although such warnings may be included in printed materials supplied with the drug, physicians prescribing Trazodone, particularly those who are not psychiatrists, might not give oral warnings."
This is conjecture and needs to be cited or removed. For consistency, if this sentence is deemed acceptable, then similar phrasing should be added to every article about a prescription drug; surely any physician who is or is not a psychiatrist may make the mistake of not giving oral warnings for any drug.  —Preceding unsigned comment added by 76.209.223.215 (talk) 05:33, 11 September 2008 (UTC)
thread_title:  Physicians failing to give oral warnings 

message: Nausea/vomiting are listed both as "most common" and under "rare - gastrointestinal." Neither are cited. Which is it?  —Preceding unsigned comment added by 76.226.203.88 (talk) 20:38, 20 July 2010 (UTC)
thread_title:  Rare or common? 

message: How can "Drowsiness, fatigue, lethargy," be side effects of a sleeping pill? Quadzilla99 (talk) 10:21, 11 September 2010 (UTC)
replies: text: And even if you ARE taking it for sleep, those effects last well into the following day, which is highly undesirable. Captain Quirk (talk) 22:01, 27 May 2014 (UTC)
thread_title:  Side effects 

message: how long does trazadone useually stay in your system?  — Preceding unsigned comment added by 24.63.38.137 (talk) 18:22, 18 October 2011 (UTC)
thread_title:  re:how long  

message: In the section describing half-life: "if trazodone is taken at night..."
 What precisely constitutes night?  9pm? 3am?  And would the described symptoms still be present the following day in both of these cases?  — Preceding unsigned comment added by 99.246.101.22 (talk) 02:00, 16 February 2012 (UTC)
thread_title:  Confusing and misleading phrasing 

message: We need reliable secondary sources.  The BBC and a primary source are not OK.  This is discussed in WP:MEDREV. Jytdog (talk) 17:36, 21 April 2017 (UTC)
thread_title:  Alzheimers 

message: The prices for UK and US are listed as e.g. '10 GBP per month'. Obviously it's not 10 pounds per month for the whole NHS, so this should be corrected to 10 GBP per patient, or £10M GBP per month, etc. I can't view the source otherwise would do it.  — Preceding unsigned comment added by Mozboz (talk • contribs) 11:03, 12 March 2018 (UTC)
thread_title:  Price incorrect / clarification? 

message: "	Trazodone IR: 7 hours[4]
Trazodone ER: 10 hours[4]"
"Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013"
https://en.wikipedia.org/wiki/Trazodone#cite_note-DrugPoint-4
I have not been able to access "Truven Health Analytics, Inc. DrugPoint System" via search.--Disoff (talk) 15:13, 21 February 2020 (UTC)
thread_title:  Why has the half life source failed verification? 

message: Clinical depression encompasses a wide range of different emotional disorders. 
I recommend that a note be made that Trazadone only is effective for treating a sub-type of depression in which the patient sleeps less than 8 hours per night, or the patient has recently found themselves sleeping more than two hours less than the patient slept in the last two months, and the patient normally sleeps more than 8 hours.  
Trazadone helps emotionally depressed patients only when the sub-type of depression includes sleep-loss or unusually small amounts of sleep, such as less than 8 hours of sleep in a 24-hour period of time. Muldoonsamuel55 (talk) 11:23, 1 February 2024 (UTC)
thread_title:  Suggestion : Accentuate Effectiveness for Increasing Sleep and Downplay Effectiveness as Anti-Depressant