Talk:Brodifacoum

message: I suggest to change the section "Pharmacology" to "Toxicology". Reason: brodifacoum is used only in biocidal (rodenticidal) context, it has no pharmacologic relevance other than its toxicity. Since the only use of it is that of a poison per se, it is appropriate to discuss its dynamics and kinetics in organism as toxodynamics and toxokinetics, forming toxicology of the substance.
I therefore change the name of the section to "Toxicology".
I also add some toxicological values (half-life, LD50 values, LC50 value, estimated fatal dose for a human) from the sources quoted ( http://www.inchem.org/ ).
--84.163.124.102 00:09, 8 October 2006 (UTC)
replies: text: Excellent! Great stuff. I do wonder about this statement though (which I edited for clarity): "Dehydrated bodies also dry out more readily, possibly leaving an odorless, mummified carcass." Does anyone know about this? Is the dehydration caused by brodifacoum really significant enough to affect the manner of decomposition? It would be great to have a reference to back this up. Cheers -- FirstPrinciples 08:54, 18 October 2006 (UTC)
replies: text: Okay, I mailed a producer of a 2nd gen. anticoagulant rodenticide bait (specifically, difethialone baits, not brodifacoum, but difethialone and brodifacoum are very closely akin), that claims the drying-mummification in their product prospects and they mailed me back:
"Rückfragen beim Hersteller haben ergeben, dass die Erkenntnis des schnellen Eintrocknens der Tiere auf Anwendungsbeobachtungen beruht  und abhängig von den äußeren Bedingungen zu sehen ist."
which means
"A query by manufacturer brought, that the knowledge of fast drying of the animals [animal corpses] is based on application observations, and is seen dependant on external conditions".
So there are no real scientific observations/studies of this phenomenon yet, or I found none of the kind. I have thus no objections against removing the claim from the article, if it interferes somehow with the NPOW or objectivity of the article.--Spiperon 18:35, 25 October 2006 (UTC)

text: Well, in fact, most 2nd generation anticoagulants (most pronounced is this mummification by bromadiolone, brodifacoum and difethialone) cause dehydration (which is caused by the hypovolemia and capillary damage, leading to blood/plasma leakage and subsequent intesticial fluid compensation of progressive hypovolemia, and if the rodent doesn't drink water copiously, the dehydration thus obtained is quite significant and progressive; with damaged, leaking capillaries, the whole body becomes "leaking" and fast-drying in dry air) as far as I know, that results to prone drying of the carcass, as long as the surroundings are dry, not moist.
I observed this also in practice, when I used difethialone and brodifacoum baits against rats and mice, I found after some weeks, by cleanup of the area where rodents were active prior to baiting, multiple dry carcasses, with no signs of decay. The bodies were just like dryied in an exsiccator, perfectly conserved. When I first observed this, I was surprised, because the use of zinc phosphide or warfarin resulted often to decaying, badly smelling bodies all over the place.
I think, that an association of an anticoagulant with an antibiotic (sulfaquinoxaline) results also to more likely dry-mummification, because of the reduction of the biggest internal reservoir of the bacteria -- the intestinal microflora.
But I don't have any relevant scientific sources to support this thesis yet. Only claims supporting this I found so far are in descriptions of the rodenticidal products containing 2nd gen. anticoagulants by their manufacturers, in german. In general, claims of manufacturers are not reliable source of objective information in regard to its necessary bias, but my observations support them, so I simply accept it.--Spiperon 13:56, 18 October 2006 (UTC)
thread_title:  Pharmacology 

message: I think it should be mentioned in the article somewhere that Brodifacoum is not regarded as a humane way to kill animals. I didn't put this in myself as I wasn't sure if it had a good enough reference (nor was I sure how to reference it.) I found this paper - The Humaneness of Rodent Pest Control - G Mason, K E Littin - at the following address, which seems to describe anticoagulants as inhumane for rodent pest control.
http://www.helpinganimals.com/pdfs/TheHumanenessOfRodentControlAnimal%20Welfare-2003.pdf 
Jatoo (talk) 11:26, 28 December 2007 (UTC)
replies: text: Anticoagulants are quite consensually considered to be a "humane" method of exterminating vermin. What is a "humane way to kill", anyway?--(84.163.124.2 (talk) 15:51, 15 January 2008 (UTC)
thread_title: Humaneness

message: WTF?  This has almost nothing to do with the main article.  I don't think it belongs here. ---Zizanie13 (talk) 01:46, 9 June 2008 (UTC)
replies: text: It has now been removed.  -- Ed (Edgar181) 14:15, 20 October 2008 (UTC)
thread_title: Pit Bull Story

message: This source says c. 25 mg/kg (cat); here LD50 oral (cat) estimated as 25 mg/kg; but in here it is 0.25  mg/kg. This pdf says "Published LD50 values of brodifacoum for cats vary widely, from 25 mg kg-1 (Rammell et al., 1984;Godfrey, 1985) to 0.25 mg kg-1(Haydock and Eason, 1997).". Now what information should be used?--RicHard-59 (talk) 11:12, 12 February 2014 (UTC)
replies: text: Here] is also 25 mg/kg.--RicHard-59 (talk) 11:19, 12 February 2014 (UTC)
replies: text: Changed to: cats (oral) 0,25 mg/kg — 25 mg/kg with appr. refs.--RicHard-59 (talk) 12:14, 12 February 2014 (UTC)
thread_title:  Toxicity in cats 

message: I removed the line about vitamin C being used as an antidote.  While there is a reference given for it in the safety sheet, I'm not aware of vitamin C being used clinically.  Please correct me if is indeed used.  Andrew73 (talk) 18:22, 12 November 2012 (UTC)
replies: text: Wait.  1.  The reference is not a "safety sheet" but the FAO/WHO poison data sheet, that being quite a difference; 2.  the source quoted nor the text in the article did postulate an antidotal use of vitamin C, it is mentioned only as an adjunct to the causal therapy, i.e. vitamin K1 ± coagulation factors concentrate IV; 3.  you are not aware of vitamin C being used clinically?  How often do you treat brodifacoum toxicoses (not meaning overdoses of Coumadin and the like)?  Cheers,--134.3.94.175 (talk) 15:09, 18 October 2013 (UTC)
thread_title:  Vitamin C 

message: Several news organizations report that a lab report confirmed the existence of the rat poison in the inmates' food. Unless counterevidence turns up, we should go with the weight of the sources. HGilbert (talk) 17:39, 30 April 2015 (UTC)
replies: text: I have clarified the text accordingly. HGilbert (talk) 09:45, 3 May 2015 (UTC)
thread_title:  Brodifacoum 

message: IUPAC name - the IUPAC name is inconsistent with the structure shown; the IUPAC name is a different tautomer. This needs an explanation.
Chemical synthesis - it would be better to say brodifacoum is a member rather than derivative of the 4-hydroxycoumarin (no -) group.
Is the commercial product a pure stereoisomer? If so, the structure and name should indicate it. If not, why is a stereospecific synthesis given?
It doesn't make sense to say compound 1 is the starting ester then describe how it is made from another ester. I suggest something like: Compound 1 can be made by a simple Wittig condensation of ethyl chloroacetate with 4'-bromobiphenylcarboxaldehyde.
I recommend "reaction" instead of "then reacted".
"addition of" should be deleted.
Toxicology - Why is "T+" & "N" shown? Is this part of some designation system? If so, explain.
"resorptivity" should presumably be "absorptivity".
Brand names - d-CON (and maybe many of the others) no longer uses brodifacoum. See cen.acs.org/articles/92/i23/Maker-Rat-Poison-d-CON.html.
Treatment for humans - Should "all 3-6 hours" be "every 3-6 hours"?
Poisoning case reports - Should "Contrac" be "Contac"?
References - 12 is missing a space. 13 appears to be missing a g.
Categories - Brodifacoum is not a drug. (from 4-hydroxycoumarins entry: "The second-generation vitamin K antagonist agents, used only in this fashion as poisons (because their duration of action is too long to be used as pharmaceuticals) include..."
69.72.92.1 (talk) 05:05, 16 December 2015 (UTC)
thread_title:  various problems 

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thread_title:  External links modified