Talk:Dissociative

message: The following text was erroneously added to the psychedelic drug page:
Salvia divinorum produces two potent dissociative drugs: The Salvinorins A and B.
^^  Why would you remove that?  I'd edit it.  Salvinorin A is commonly classed as a dissociative, as it really should be. This section is on dissociatives- drugs that dissociate mind from body.  Kappa agonists definitely accomplish this.
The problem with that statement, though, is that Salvinorin B isn't a kappa agonist, isn't an NMDA antagonist and isn't even ACTIVE according to anything I've seen- though as far as I know, no ones' ever looked to see if it has affinity for non-opioid receptors (It'd be interesting to know if it has sigma affinity)
66.188.254.66 (talk) 01:03, 15 July 2008 (UTC)
thread_title:  Text removed from [[Psychedelic drug]] page, to be edited and added to this page 

message: From the page Effects of nitrous oxide on the body, "It (N2O) inhibits the NMDA receptor at partial pressures similar to those used in general anaesthesia (Jevtovic-Todorovic et al., 1998; Mennerick et al., 1998; Yamakura & Harris, 2000)." Therefore, I think that N2O should not be classified as an inhalant (which merely discribes its method of intake) and move it under NMDA Receptor Antagonists. I'll move this but I'm open to discussion if anyone believes otherwise.
Also, this opens the possibility of N2O causing Olney's Lesions. However, it is possible that it does not cause cellular vacuolization because of its effect on the GABA receptor (and inhibiting the GABA receptor helps prevent vacuolization.) Either way, I'd like someone more qualified than me to verify both my changing of its classification and the possibility of Olney's Lesions. Jolb 23:25, 16 January 2007 (UTC)
thread_title:  Nitrous Oxide 

message: Paragraph cites no sources and seems based entirely on the subjective experience of the person who wrote it.  I recommend it either be removed or find sources to support the claims.  —Preceding unsigned comment added by PhishHeadSCI (talk • contribs) 03:04, 23 October 2008 (UTC)
thread_title:  First paragraph of introduction 

message: In the first line of Deliriant article it says "The deliriants (or anticholinergics) are a special class of acetylcholine-inhibitor dissociatives." So are deliriants a sort of subclass of dissociatives and if they are should they be mentioned in this article? --Ahabvihrea (talk) 18:40, 27 November 2008 (UTC)
replies: text: Yes, they should be mentioned with a See deliriants link.  They have their own article because while they are a sort of dissociative, they are in a class of their own.  --Thoric (talk) 16:52, 10 February 2009 (UTC)
replies: text: How are deliriants dissociative? I've never heard of or experienced dissociative effects(sensory deprivation for example) from deliriants. Just delirium. YVNP (talk) 03:04, 5 November 2009 (UTC)
thread_title:  Acetylcholine-inhibitor dissociatives 

message: Is Dextromethorphan an uncompetitive channel blockers?  —Preceding unsigned comment added by 77.98.23.196 (talk) 13:26, 10 February 2009 (UTC)
replies: text: Yes.  All of the most common NMDA antagonists are uncompetitive, though this is a mater for the NMDA antagonist article. 98.71.213.91 (talk) 16:21, 8 October 2009 (UTC)
thread_title:  DXM 

message: "Hallucinations from these dissociatives are generally only experienced in dark rooms or with eyes closed, unless at very high doses above what is normally consumed recreationally"
I've taken DXM at doses of 300(which is quite a rather low recreational dose) and experienced CEVs and visual distortion(everything turned choppy and colors were much brighter). I've also read on Erowid and it seems DXM does indeed have visual effects. This statement seems to be suggesting dissociatives are not "real" drugs and therefore can't possibly make you hallucinate. removed YVNP (talk) 03:02, 5 November 2009 (UTC)
thread_title:  Dissociatives aren't hallucinogens? 

message: I think most people would agree that Ketamine (a NMDA receptor antagonist) and Salvia Divinorum (a κ-opioid receptor agonist) have quite different psychological effects. Wouldn't it be better to put κ-opioid receptor agonists into a group called dysphoriants?Zanthius (talk) 16:40, 1 March 2015 (UTC)
thread_title:  Wouldn't it be better to put κ-opioid receptor agonists in a different group? 

message: The content below is almost entirely unsourced and has degenerated into an indiscriminate list of compounds that fall into various categories.    
I moved it here per WP:PRESERVE.  Per WP:BURDEN please do not restore without finding independent, reliable sources, checking the content against them, and citing them, and ensuring that this content has appropriate WP:WEIGHT in the article overall.  Not at all sure that this list cluster belongs anywhere tho. 
;Classes  
;NMDA receptor antagonists
; Adamantanes
* Amantadine
* Memantine
* Rimantadine
; Arylcyclohexylamines
* 2-Fluorodeschloroketamine (2-F-2'-Oxo-PCM, fluoroketamine, 2-FDCK)
* Deschloroketamine (O-pcm, 2'-Oxo-PCM, DCK)
* Dieticyclidine
* Esketamine
* Eticyclidine
* Gacyclidine
* Ketamine
* Metaphit
* Methoxetamine (3-MeO-2'Oxo-PCE)
* Methoxmetamine (3-MeO-2'Oxo-PCM)
* Phencyclidine 
*  Phenylhexylcyclopyrrolidine
* Rolicyclidine
* Tenocyclidine
* Tiletamine
* Methoxydine (4-MeO-PCP)
* 3-MeO-PCP
* 3-MeO-PCE
* O-PCE (2'-Oxo-PCE)
* 2-TFMDCK (2-Trifluoromethyldeschloroketamine)
; Morphinans
* Dextromethorphan
* Dextrorphan
* Methorphan
* Morphanol
; Diarylethylamines
* Diphenidine
* Ephenidine
* Fluorolintane
* Methoxphenidine
* Remacemide
; Others
* 2-MDP
* 8A-PDHQ
* Aptiganel
* Chloroform
* Dexoxadrol
* Diethyl ether
* Dizocilpine
* Etoxadrol
* Ibogaine (found in Tabernanthe iboga)
* Midafotel
* NEFA
* Nitrous oxide
* Neramexane
* Noribogaine
* PD-137889 (P-89)
* Perzinfotel
* Selfotel
* Xenon
; Naturally occurring
* Rhynchophylline
;κ-opioid receptor agonists 
* 2-EMSB
* 2-MMSB
* Alazocine
* Bremazocine
* Butorphanol
* Cyclazocine
* Cyprenorphine
* Dezocine
* Enadoline
* Herkinorin
* HZ-2
* Ibogaine
* Ketazocine
* Metazocine
* Nalbuphine
* Nalfurafine
* Nalorphine
* Noribogaine
* Phenazocine
* Pentazocine
* Salvinorin A (found in Salvia divinorum)
* Spiradoline
* Tifluadom
* U-50488
;GABAergics 
* Muscimol
* Zolpidem
* Zaleplon
* Zopiclone
-- Jytdog (talk) 00:52, 31 July 2017 (UTC)
thread_title:  Unsourced, [[WP:NOTCATALOG]]