Talk:Tryptophan

message: If it's so plentiful in normal foods like eggs and meat why does supplementation with L-Tryptophan help with all of these different conditions. I don't know enough about chemistry so if someone could help me understand this I would love it.  —Preceding unsigned comment added by 70.102.163.132 (talk) 04:42, 31 January 2008 (UTC)
replies: text: Amino acids behave differently when they are ingested alone vs. when they are competing with other amino acids. Pocopocopocopoco (talk) 05:28, 31 January 2008 (UTC)
thread_title:  Why Supplementation? 

message: I unfortunately don't have a source for this, but I believe it is accurate physiologically speaking... (if you can say that...)
What _does_ happen when you eat a large meal of turkey (or any other large meal), is that your stomach fills up (of course) and this decreases the amount of space left in your abdominal and chest cavities for where the lungs normally expand into. Therefore you're actually decreasing the amount of air actually getting to your brain-- not to any amount critical of worry, but your body decides to save some energy, activate components of your parasympathetic nervous system, (rest and digest) and get drowsy. It's basic physiology, any B.Sc knows that... Someone should add it to the article, I'd be happy to if someone can ensure me it's not going to get instantly deleted for lack of sources. Let the health science graduates who know the science have a say. purpleidea (talk) 17:20, 5 June 2008 (UTC)
replies: text: If what you say is true (referenced or not), I still can't see a reason for it it to be added to this article.  As there is no reason for turkey meat specifically as opposed to any other meat, or indeed any other food, to cause this effect.  If this is the mechanism by which eating large amounts of food causes drowsiness or fatigue, it'll probably be mentioned somewhere else on wikipedia, and a simple sentence with a link, rather than the long-winded explanation should suffice! Alex (talk) 20:39, 7 June 2008 (UTC)
thread_title:  Turkey meat and drowsiness 

message: Why banana is claimed to have plenty of tryptophan, when it actually has almost none? Sure the t/p-ratio is nice, but not only it has nothing to do with the actual t-content of bananas, there is also little or no explanation what this ratio actually does.
--80.222.42.200 (talk) 15:32, 6 August 2008 (UTC)
thread_title:  Tryptophan and Bananas - an urban myth 

message: This article has a POV template from October 2008, but there is no discussion on the talk page about potential POV since August. If these issues have been resolved the POV template should be removed. If there are other issues, please raise them here on the talk page and resolve them. Tamino (talk) 08:52, 18 October 2008 (UTC)
replies: text: The justification for adding the  template in this edit was "Tagged article as biased in anticipation of reverse edits" which in my opinion is not sufficient justification.  This template should only be used for alert readers to biases which may exist in the current version of the article.  If the bias has been removed, then the template should be removed. Furthermore the template should not be used in anticipation of possible future biases.  Adding a template to warn users of bias when in fact none exists only serves to confuse readers.  Therefore I have removed the template. Cheers. Boghog2 (talk) 09:12, 18 October 2008 (UTC)
thread_title:  Why the POV template? 

message: There is a new study which claimed to indicate that tryptophan deprivation lowered seratonin levels and reduced bone loss. 
http://www.nytimes.com/2008/11/27/health/research/27bone.html?  —Preceding unsigned comment added by 75.171.36.132 (talk) 15:59, 27 November 2008 (UTC)
thread_title:  tryptophan relation to seratonin levels and osteoporosis 

message: The many technical details about Fluorescence were removed from this article and sent to the article where fluorescence is treated in metrology, namely the article on Fluorescence spectroscopy#Tryptophan_Fluorescence. In other words, the information will be more appreciated there where fluorescence is the topic rather than the protein. I like to saw logs! (talk) 03:51, 4 January 2010 (UTC)
thread_title:  Fluorescence 

message: The section saying that 5-HTP creates a risk of heart valve disease should say that it may have a risk, as the citations relate to direct administration of serotonin.  So although this is a fairly logical conclusion, it shouldn't be written as absolute truth.174.3.107.124 (talk) 05:41, 7 March 2010 (UTC)
thread_title:  5-HTP Heart Risk 

message: in the figure, the 3rd step involves n-(5'-phosphoribosyl)-anthranilate, the steps are alright but it's structure is inaccurate. The N of anthanilate should be directly bonded to the ribose ring, yet the figure shown has a kink, which indicates the presence of another C before connecting to the ribose ring, and is wrong.
I have also checked the Lehninge. plx replace the fig.  — Preceding unsigned comment added by 203.188.72.157 (talk) 10:25, 11 September 2011 (UTC)
replies: text: Yes, there does appear to be an error in the image.  I have asked the creator of the image to have a look and fix it.  Thanks for catching the error and reporting it here.  -- Ed (Edgar181) 11:47, 11 September 2011 (UTC)
replies: text: Thanks for spotting the error.  The figure has now been corrected.  Boghog (talk) 12:17, 11 September 2011 (UTC)
thread_title:  Wrong figure in Trp biosynthesis from chorismate 

message: It is an essential amino acid as demonstrated by its growth effects on rats.
this could use citation  — Preceding unsigned comment added by 69.146.244.19 (talk) 11:06, 22 October 2012 (UTC)
thread_title:  citation? 

message: Under the heading "Function," lactose intolerance is referred to as a disorder.  This seems an odd way to describe the common conditions of all other mammals and most humans.  Does the entire population of Thailand, for example, suffer from a "disorder" as a result of lacking one of the relevant mutations?  It may rarely occur as a disorder, but it is otherwise the human norm.  A failure to recognize its normality can cause problems in increasingly diverse urban societies.
24.7.237.175 (talk) David Harley 11/23/12  —Preceding undated comment added 17:29, 23 November 2012 (UTC)
thread_title:  Lacose intolerance 

message: Hi, This might be a major undertaking to correct, but, for what it's worth, I would like to set the record straight in pointing out that in the diagram under the header "Biosynthesis and industrial production", the last molecule in the chain has a typo and should, of course, read: "tryptophan". Safetydude (talk) 23:44, 26 November 2012 (UTC)
replies: text: I've asked RicHard-59 to fix it at commons:User_talk:RicHard-59#File:Tryptophan_biosynthesis_.28en.29.svg. --Rifleman 82 (talk) 01:05, 27 November 2012 (UTC)
thread_title:  Minor Correction in diagram for synthezing of tryptophan 

message: The article should mention how tryptophan can be used to make vitamin B3 niacin.  — Preceding unsigned comment added by 75.102.127.173 (talk) 13:44, 31 March 2014 (UTC)
thread_title:  Talk about Tryptophan into Niacin 

message: http://www.nemsn.org/Articles/truth_about_tryptophan.htm
:What is the question? Jytdog (talk) 22:05, 1 June 2014 (UTC)
thread_title:  Article with cites about the Showa Denko impurities.  GMO or no?   

message: I would like to point out that the scope of this article is wider than WP:MED, it also includes WP:MCB.  As long as it is made clear that the studies are in animals, this should be fair game to include a section on tryptophan and aging. A good secondary source that discusses the evidence is here: . Boghog (talk) 14:53, 29 December 2014 (UTC)
replies: text: i really struggle with this boghog.  at the end of the day, nobody cares whether mice live longer. the work in mice, and the reporting of it, only matter because people are trying to understand human health, and, i would guess, longevity freaks would read this and say "oh, i will for sure avoid tryptophan going forward" ugh. Jytdog (talk) 15:22, 29 December 2014 (UTC)
replies: text:  Some people are also interested in basic research. Of course, the reason why this research is funded is that it may eventually be applied to improve human health. The attitude that we should not include such information since it might be misinterpreted by some people amounts to censorship. Boghog (talk) 15:48, 29 December 2014 (UTC)
replies: text: nope, censored is irrelevant to this.  Please see WP:MEDRS and WP:MEDMOS.  We don't provide the public with information about health based on animal studies. Jytdog (talk) 16:48, 29 December 2014 (UTC)
replies: text:  Wikipedia is the sum of all human knowledge.  Animal studies are part of that knowledge. WP:MEDRS only applies to content that is within the scope of WP:MED and as I have stated above, the scope of this article is wider than WP:MED. Boghog (talk) 17:26, 29 December 2014 (UTC)

text:  While we are quoting Wikipedia guidelines, I would suggest that you read the WP:MEDANIMAL section of WP:MEDRS which reads in part   So even MEDRS allows animal studies as long as it is carefully worded.  Boghog (talk) 18:50, 29 December 2014 (UTC)
replies: text: ok, so based on secondary sources, and no UNDUE weight, and properly couched. Jytdog (talk) 20:42, 29 December 2014 (UTC)
thread_title:  Tryptophan and aging 

message: The first structure on the right hand side is wrong with an extra carbon. https://en.wikipedia.org/wiki/Tryptophan#/media/File:L-Tryptophan_physiological_ACS.png The second structure is right.
Why are there 2 pictures of tryptophan, with the second being called ball and stick model while it is clearly not?  — Preceding unsigned comment added by Hieniemic (talk • contribs) 16:00, 23 December 2015 (UTC)
thread_title:  Wrong structure 

message: The article reads:
:Tryptophan affects brain serotonin synthesis when given orally in a purified form and is used to modify serotonin levels for research in psychology.[33]
Unfortunately I do not have access to the source text.  It however appears unlikely to me that psychology was the intended word in this context. 76.10.128.192 (talk) 05:46, 7 January 2016 (UTC)
replies: text: I have simply removed "in psychology", the reference is about pharmacology, neurology, perhaps psychiatry.  PaleoNeonate (talk) 11:29, 15 March 2017 (UTC)
thread_title:  In psychiatry or in neurology? 

message: The drug laws in Europe are very strict, particularly with the Indication "depression" or "insomnia", and L-tryptophan (or melatonin) is available as a prescription drug only. Its use as a dietary supplement in non-approved products is illegal, with a few exceptions in the Netherlands and the UK where non-registered supplements are much more tolerated. I am not necessarily an advocate of strict regulation but it is interesting to see how well-controlled the continental Europeans are approaching this. Osterluzei (talk) 06:57, 16 February 2016 (UTC)
thread_title:  Regulatory

message: I was looking for the crystal structure of pure L-tryptophan to illustrate this article and found that it had only recently been determined: G. M. Day and co-workers, Acta Cryst. (2012). B68, 549-557. That paper notes that the crystal structures of the pure forms all the other standard L-amino acids apart from L-lysine have been determined.
Is there consensus yet on how to show the 3D structures of amino acid molecules? The issue is the zwitterionic forms are more realistic but confusing for some readers, whereas the neutral forms are simpler but do not exist in reality (perhaps with the exception of some strange gas-phase situation). We have a neutral structure, :File:L-Tryptophan - L-Tryptophan.svg, in the Chembox at the moment, but that form is more of a concept than a real structure because one of the acid groups would protonate the amine forming a zwitterion.
Has this dilemma been settled elsewhere?
--Ben (talk) 11:09, 27 April 2016 (UTC)
thread_title:  Crystal structure of <small>L</small>-tryptophan 

message: The value "0,08" (if You calculate  2.34 % from 3.22 g, You get exactly 75 mg) is definitely wrong; searching the USDA database leads to 0,046g =(46 mg). --Cvf-ps (talk) 14:30, 4 December 2016 (UTC)
thread_title:  Tryptophan in milk 

message: Using data from nutritiondata.self.com, ground beef has a tryptophan to protein ratio of approximately 0.5%, rather than the table's listing for beef of 1.12%.  The entry for turkey does seem accurate though, at 1.11%.  I couldn't find any specific data on tryptophan content from the cited USDA database.  — Preceding unsigned comment added by 63.155.229.130 (talk) 17:51, 14 December 2017 (UTC)
thread_title:  Data table inaccuracy 

message: It says that "Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a non-polar aromatic amino acid". The "α-carboxylic acid group" is incorrect, it should be simply "carboxylic acid group" without the"α". The "carboxylic acid group" is the primary functional group and the positions of the other functional groups such as the amino group or the indole side chain are given relative to the carboxylic acid group. The "α-amino group" is correct, because the amino group is in the "α" position relative to the carboxylic acid group. This means that it is attached to the C atom adjacent to the carboxylic acid C atom.
Secondly, making it a non-polar aromatic amino acid" is not correct. It is aromatic, but not completely non-polar. Instead, you could maybe say "making it a fairly non-polar aromatic amino acid" or "making it an aromatic amino acid that is far less polar than most other α-amino acids found in protein". Note that phenylalanine is also an aromatic α-amino acid that should also be fairly non-polar (or have a fairly low polarity).
155.240.161.3 (talk) 08:36, 14 May 2019 (UTC)
thread_title:  Corrections to first paragraph of the article 

message: is L-tryptophan that same as tryptophan? I can't see anything on the page but they seem to be interchangeable terms. please remember people might come here after reading a bottle of supplements or an article and not have chemistry knowledge. 84.67.13.0 (talk) 16:15, 29 March 2023 (UTC)
thread_title:  L- 

message: Chinese, Japanese, and Spanish articles show right structure, though this English article shows wrong pictures in which the under Nitrogen atom is connected to 3 (not 2) Hydrogen atoms and I cannot find Carboxy group around there. In French article there are no 3D pictures.
I am sure these pictures should be copied from other language articles, or just get removed. 240B:C020:4B1:55CC:3D8D:9B28:97D5:C2BC (talk) 13:07, 14 August 2023 (UTC)
thread_title:  Wrong structure 2 

message: g/100 g is probably the wrong unit for tryptophan content. Should probably be mg / 100 g 194.207.180.128 (talk) 19:55, 8 March 2024 (UTC)
replies: text: Don't think so - the values stated are consistent with Tryptophan/protein %, so what makes you think there is a 1000-fold error? Plantsurfer 20:35, 8 March 2024 (UTC)
thread_title:  Inaccurate data table