lflage/wiki-talks huggingface dataset:
Talk:Sex hormone-binding globulin

message: What does the abbreviation CBG stand for?  — Preceding unsigned comment added by RChase (talk • contribs) 19:07, 16 December 2020 (UTC)
thread_title: Affinity and Binding chart

message: Does SHBG have higher affinity for testosterone or estradiol? /Eribro (talk) 20:10, 30 December 2007 (UTC)
thread_title: Affinity

message: This article appears to be about the protein.  Now, every protein has its gene, but the protein is of more interest biochemically (and the gene, well genetically).
Secondly, is it unique to humans?  Well, a quick BLAST search shows human sex hormone-binding globulin is homologous to mouse hormone-binding globulin (this is not surprising evolutionarily -- if it had been unique to humans it would have been of more interest). I am not a dog (talk) 16:39, 17 April 2008 (UTC)
thread_title:  human gene? wtf? 

message: How the hell SHBG is the same as SHGB? The acronym works only in the 1st case, I see. The same thing, I noticed, is for the HBG/HGB meaning Hemoglobin.Vinne2 (talk) 06:08, 17 May 2010 (UTC)
thread_title:  acronym 

message: Isoform; high overlap. Artoria2e5 🌉 14:24, 18 January 2022 (UTC)
replies: text: Klbrain (talk) 06:26, 14 August 2022 (UTC)
thread_title:  Proposed merge of [[Androgen-binding protein]] into [[Sex hormone-binding globulin]]
Talk:Flippase

message: Now that there is a shorter article on flippase on Wikipedia, I plan to improve on the following three points, representing from top to bottom high to low priority.
1.     This article doesn't cover the different domains of flippase and what its different domains do. I will add an introduction to the different domains and an image of the flippase domain with text.
2.     There is only a textual description of the flippase mechanism, which will be difficult for the reader to understand. I will add a schematic diagram to make it easier for readers to compare the graphic and text, which is more convenient for readers to understand.
3.     The article is vague about the classification of flippase. I will reorganize and rewrite the section on categorization so that can reduce the ambiguity. -- Ray1590 (talk) 22:04, 11 March 2024 (UTC)
thread_title:  advice to change this article 

message: — Assignment last updated by UBC24 AT (talk) 04:21, 1 April 2024 (UTC)
thread_title: Wiki Education assignment: CHEM 300
Talk:Jean-Marie-Rodrigue Villeneuve

message: His role in controversial part of Canadian History:
From Official archives, of Canada: 
Archdiocese of Quebec, The Chancellery
Quebec, 27 June, 1940
Dear Sir:
His Eminence the Cardinal would be happy if you would draw the attention of the Right Honorable Mr. Ernest Lapointe, Minister of Justice, to the enclosed leading editorial of Quebec, concerning the publications of the Watch Tower or Jehovah’s Witnesses.
Certain books and pamphlets again recently addressed through the mail, and in particular the periodical Consolation, are all that which is the most demoralizing and most destructive of the spiritual strength of the country.
Thanking you in advance, dear Sir, for your kind attention to this letter, I remain
Yours very truly,
Paul Bernier, Chancellor
To: The Private Secretary
of the Rt. Hon. Ernest Lapointe
Minister of Justice
OTTAWA, Ontario
The foregoing letter was, in reality, a demand from the cardinal that Lapointe have Jehovah’s Witnesses declared illegal. Lapointe knew his power depended on the cardinal and was quick to respond. The next feature in this drama of secrecy and intrigue is the following letter (translated from French), sent one week later by Lapointe’s private secretary to Cardinal Villeneuve’s chancellor:
PERSONAL
July 4, 1940
Monsignor Paul Bernier
Chancellor of the Archdiocese
Palace of the Cardinal
QUEBEC
Mr. Chancellor:
Upon receipt of your letter of June 27, I took it upon myself to fulfill His Eminence the Cardinal’s desire to direct the attention of the Minister to your representations as well as to the editorial published by L’Action Catholique with regard to the Watch Tower, Jehovah’s Witnesses and Consolation.
Mr. Lapointe gave me permission to let you know by telephone the confidential information that the said organization of Jehovah’s Witnesses would be declared illegal as of today, with the request that His Eminence, the Cardinal, be informed of this.
This letter is to confirm that which I just told you over the telephone.
I understand that His Eminence the Cardinal will be duly informed of the departmental order regarding Jehovah’s Witnesses.
Please accept, Mr. Chancellor, my expression of thanks and my warmest regards.
The letter was signed by Lapointe’s private secretary. From the time of the cardinal’s demand, it had taken just seven days to get the ban imposed. There was great rejoicing in the cardinal’s palace. His chancellor wrote to Lapointe’s private secretary on July 8, 1940. As translated from French, that letter stated:
I am most obliged by your eagerness to draw the attention of the Right Honorable Mr. Lapointe to the subject of my letter of June 27.
I have no need to add,—since His Eminence will have already written to Mr. Lapointe to state his satisfaction over the departmental order in question,—just how much such a prompt and happy solution deserves our commendation and thanks.
Please accept a renewed expression of my gratitude and of my deepest regards.
Paul Bernier, priest. - Thank-you!--Anaccuratesource (talk) 04:53, 23 April 2009 (UTC)
thread_title: Untitled
Talk:Fucosyltransferase

message: Should the discovery of the FUT1-gene not be mentioned in particular?
It can be described here http://anthro.palomar.edu/blood/Bombay_pheno.htm and here
http://en.wikipedia.org/wiki/Hh_blood_group <-- the latter is an in-wikipedia 
page, which even mentions the enzyme here but unfortunately does not link
to it. Probably whoever wrote or edited the second link did not know that
the page here exists, or this page here was created afterwards. 84.113.183.242 (talk) 18:53, 6 November 2014 (UTC)
thread_title:  Bombay phenotype
Talk:GTP cyclohydrolase I

message: This is a note from the article:
::"NB: The numbering of the carbons of the pentose sugar is incorrect. The first carbon is the one attaching the purine and the fifth is the one attaching the phosphate. The image needs correction please.
::"
It is way over my head! -- Alan Liefting (talk - contribs) 05:07, 27 October 2012 (UTC)
thread_title:  A note from the article
Talk:Galactokinase

message: GALK2 has EC 2.7.1.157 so is wrong here. --Ayacop (talk) 09:54, 20 December 2008 (UTC)
replies: text: Should the infobox be moved to N-acetylgalactosamine kinase? Fvasconcellos (t·c) 16:03, 20 December 2008 (UTC)
replies: text: Ah yes, I think so. But note the EC. --Ayacop (talk) 17:05, 24 December 2008 (UTC)
thread_title:  GALK2 not here
Talk:Phosphotransferase

message: I added the Phosphotransferasesystem. Maybe it does not directly belong to "Phosphotransferase", but 
i think that its an important piece of knowledge to add nevertheless (as an example), and used a lot 
in bacterias.
Bacteria is plural, bacterium is singular.  —Preceding unsigned comment added by 140.160.11.222 (talk) 22:27, 8 February 2009 (UTC)
thread_title: Untitled
Talk:Basic points unifying Theravāda and Mahāyāna

message: The link to the term ecumenical refers to ecumenism as a Christian movement, while this article is about a Buddhist statement. 
Here are three short paragraphs from the actual statement from the Wikipedia article on ecumenism:
Ecumenism refers to efforts by Christians of different church traditions to develop closer relationships and better understandings. The term is also often used to refer to efforts towards the visible and organic unity of different Christian churches in some form.
The adjective ecumenical can also be applied to any interdenominational initiative that encourages greater cooperation among Christians and their churches, whether or not the specific aim of that effort is full, visible unity.
The terms ecumenism and ecumenical come from the Greek  (oikoumene), which means "the whole inhabited world", and was historically used with specific reference to the Roman Empire."Ecumenical" at dictionary.com The ecumenical vision comprises both the search for the visible unity of the Church (Ephesians 4:3) and the "whole inhabited earth" (Matthew 24:14) as the concern of all Christians.
I suggest that we search for a different term and POSSIBLY (I like this idea) claim that Buddhism 'ecumenism' is parallel to or analogous to Christian 'ecumenism' (which indeed, refers to a one world movement of globalism and religious response to globalism.  It may be possible to refer to:
* post-traditional form of humanism
* post-cultural restatement of a unifying spiritual tradition
* a spiritually unifying tradition that is both ethical and post-religious
IMO, each of these possible directions for developing this article seems problematic and likely to raise further questions about the encyclopedia.   MaynardClark (talk) 12:50, 28 October 2016 (UTC)
thread_title: Buddhist ecumenical statement created in 1967
Talk:Gelatinase

message: — Assignment last updated by Akusen (talk) 05:11, 9 October 2023 (UTC)
thread_title: Wiki Education assignment: Marine Molecular Science Fall 2023
Talk:Farnesyltransferase inhibitor

message: In the section on Alternative Uses of FTIs under Alzheimer's, the abbreviation HD is used thrice without explanation. Human Dementia? Huntington's Disease? The contributor please clarify. The relevant reference #4 is a dead link. — Preceding unsigned comment added by Jmostly (talk • contribs) 11:57, 28 March 2019 (UTC)
thread_title:  Meaning of HD?
Talk:Glucose 6-phosphatase

message: I had a real tough time figuring this out - there are three genes in the glucose 6-phosphatase family of proteins.  The genes are G6PC, G6PC2, and G6PC3.  They are distinct from each other.  What I propose is that G6PC be merged into this article and the article focused more on the G6PC gene product and related diseases, and then links to the articles for the other two genes.  But I am open to other suggestions.   Gccwang (talk) 03:55, 15 August 2014 (UTC)
replies: text: If there was a one to one correspondence between enzyme and gene (e.g., only one gene in the human genome that encodes a particular enzyme reaction), then I would support the merger.  However in this case we have three genes (G6PC, G6PC2, and G6PC3) that encode enzymes with  activity.  Merging only G6PC into this article does not make sense.  Either all four articles should be merge or none.  Furthermore including three protein infoboxes in the same article is not practical, hence I believe the four articles should not be merged.  I would instead propose to edit the present article to include more information on how the three isozymes differ (e.g., tissue distribution, structure, function, etc.).   looks like a good review for this purpose.  I will try to work on this weekend.  Boghog (talk) 05:24, 15 August 2014 (UTC)
replies: text:  Thanks, I agree. Gccwang (talk) 21:27, 16 August 2014 (UTC)
replies: text:  Page edited for clarity and merger proposal withdrawn. Gccwang (talk) 18:17, 21 August 2014 (UTC)
thread_title:  Merger proposal
Talk:Fructose 6-phosphate

message: Check the declared stereo in the name and the stereo on the molecule
The molecule as drawn is 
[(2R,3S,4S,5S)-3,4,5-trihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate--ChemSpiderMan (talk) 19:32, 12 January 2008 (UTC)
thread_title:  Structure and name do not match 

message: The structure as drawn is not consistent with the name…which is right?  —Preceding unsigned comment added by ChemSpiderMan (talk • contribs) 04:16, 13 January 2008 (UTC)
thread_title:  Inconsistencies between name and structure 

message: The structure shows the alpha anomer, and it is inconsistent with the structure shown in the article for fructose 1,6-bisphosphate. Please correct  — Preceding unsigned comment added by 129.194.231.5 (talk) 11:59, 10 July 2020 (UTC)
thread_title:  Wrong structure of beta-D-fructose 1,6-bisphosphate 

message: The Wikipedia article called "Glyceraldehyde_3-phosphate" https://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate shows the same diagram but calls it β-D-fructose 1,6-bisphosphate. Also, searching for α-D-fructose 1,6-bisphosphate came up with very little. Arctic Gazelle (talk) 19:32, 3 September 2021 (UTC)
thread_title:  What is labelled α-D-fructose 1,6-bisphosphate should be labelled β-D-fructose 1,6-bisphosphate?
Talk:Leitrim, County Leitrim

message: I have deleted the reference to Leitrim Station, as there was no such station on the Cavan & Leitrim Railway or on any railway line.
There was a Leitrim railway station, but in County Down on the GNR(I) line between Scarva and Castlewellan.Ewanduffy 18:16, 6 November 2007 (UTC)
Talk:Freilichtmuseum Roscheider Hof

message: I removed most of the content of this article, because it was identical to images and text of the homepage http://www.roscheiderhof.de/home/index.php5. If the content is not written by the editor of this homepage, there has to be a Copyright Violation. --Thw1309 12:07, 5 June 2007 (UTC)
replies: text: Please explain the reason why this should not be a Copyright Violation. Text and pictures are taken from this website. If you can not give a reasonable explaination I will ask for this article to be deleted.--Thw1309 10:24, 7 June 2007 (UTC)
replies: text: This is my own work. I am the volunteer webmaster of this museum. See http://www.roscheiderhof.de/museumsinfo/adresse.php5. I have written this text (in German). It has been translated by a professional translator. --HelgeRieder 14:53, 8 June 2007 (UTC)
thread_title: Suspected Copyright Violation
Talk:S100

message: The Soviet SAM system has no NATO reporting name, because it's not a separate system but a mix of S-50, S-75, "Dal" (), S-125, and, later, S-200 elements to build regional air defense of Leningrad (,   --Yuriy Lapitskiy 23:40, 16 February 2007 (UTC)
thread_title:  S-100 SAM
Talk:Glycogen phosphorylase

message: An expansion of the mechanism by which the enzyme breaks glycogen would be helpful.  —Preceding unsigned comment added by Templemd (talk • contribs) 04:37, 7 November 2007 (UTC)
thread_title: Untitled

message: 109.186.40.245 (talk) 11:15, 24 August 2010 (UTC)
replies: text: I must admit, I wasn't aware that adrenaline acted via α1 and Gq in the liver. With that in mind, perhaps it should also be explained in the article that adrenaline acts via this pathway, if it hasn't already been explained (I haven't read the whole article). I will revert my last edit, since it appears that the current information is not completely accurate and could become confusing, as you suggested. GiftigerWunsch [TALK] 11:47, 24 August 2010 (UTC)
thread_title:  Glucagon vs. Adrenaline in the activation pathway 

message: The section mechanism says: "The protonated oxygen now represents a good leaving group, and the glycogen chain is separated from the terminal glycogen in an SN1 fashion, resulting in the formation of a glucose molecule with a secondary carbocation at the 1 position."
The term glycogen is repeated twice. I wonder if the second glycogen should be glucose instead of glycogen.--Miguelferig (talk) 16:13, 29 August 2012 (UTC)
thread_title: A question

message: The arrows in the mechanism figure are incorrect. In chemical mechanism, one moves electrons with curly arrows, not atomshttp://www.chemguide.co.uk/basicorg/conventions/curlies.html.  If I knew how to upload a png file, I would edit the page directly.  I would like help making these changes. Davidbear61 (talk) 20:33, 8 June 2015 (UTC)
thread_title: A correction needs to be made
Talk:Glutamine synthetase

message: I saw references to bacteria and plants in the text, is this Enzyme Relevant to humans?  — Preceding unsigned comment added by Leopardtail (talk • contribs) 18:58, 29 April 2014 (UTC)
replies: text: I believe so because it says astrocytes... 2A02:1812:1126:5D00:7487:A569:C09A:8ACD (talk) 07:14, 21 September 2023 (UTC)
thread_title:  Relevant to Eukaryotes 

message: 1- I think that the adenylylation reaction miss a word: I suppose you mean:
(Adenylyl transferase and PA reduces GS activity by attaching an AMP unit to GS) instead of saying:
(PA reduces GS activity by attaching an AMP unit to GS).
the reason is what has been already said earlier: 
→ ("Adenylyl transferase" catalyzes the adenylylation and phosphorolysis reactions.[8] 
Adenyl transferase activity is "influenced" by two regulatory proteins: PA and PD)
so the reaction caused by the enzyme & PA only influence it, when mentioned alone it looks as it carry out the reaction alone which contradict the above statement (the arrow)
2- I will try to re-explain this phrase:
(Glutamate is another product of glutamine metabolism; however, glutamate is a substrate for GS inhibiting it to act as a regulator to GS.)
what I got from that line: in glutamine synthetase: not only the product (glutamine) show feedback inhibition, but also the downstream metabolites of this product (the farther away products)
one of them is glutamine (apparently by some other enzyme) so this particular product is an exception (it stimulate the GS) because this metabolism "re-create" the substrate
3- this is a question rather than a remark: you said:
Methionine Sulfoximine is an irreversible, non-covalent inhibition of GS.
(but aren't all irreversible inhibitors covalent? and if it is non-covalent it means reversible? that what I was thinking ??)
Yasir muhammed ali (talk) 07:54, 12 April 2016 (UTC)
thread_title:  few remarks about regulation 
Talk:Glutathione reductase

message: Frankly I don't get what the use is of showing the backbone of the structure of an enzyme - not just here but on many pages, and many books do it, too. What does it do for our understanding of the enzyme's activity? It's like a beauty pageant with X-ray images.  —Preceding unsigned comment added by 129.97.47.64 (talk) 15:15, 24 November 2010 (UTC)
replies: text: The scope of this article is wider than function, it also includes structure. So I think it is figure with the back bone is appropriate to include in the . To attract readers, a little eye candy IMHO is a good thing. I also think the :File:Glutathione_reductase.png figure is better than most Gene Wiki protein graphics  since it at least highlights the substrate and cofactor.  Finally since an Enzyme Commission number represents a reaction catalyzed by an enzyme, not the enzyme itself, therefore I think it would be appropriate if the :File:GSR_Model_Figure.PNG in the  is replaced with a figure that focuses on the active site of the enzyme determined from a crystal structure.   describes a series of very high resolution structures that capture various intermediate states of the reaction.  I will try to produce something better. Boghog (talk) 10:47, 9 September 2014 (UTC)
thread_title:  Protein structure
Talk:Juliana Berners

message: A Fictitious Character?
It has been alleged that Dame Juliana was a fictitious person, or perhaps a pseudonym of one or more authors. This is not mentioned in the article so should it be concluded that these claims are false or at best `fringe'?  Barney Bruchstein (talk) 20:27, 9 March 2021 (UTC)
thread_title: Untitled
Talk:Glutathione synthetase

message: Thank you for expanding this article!  A couple of notes:
*  These infoboxes were removed twice without explanation.  These infoboxes useful information about structural domains of this enzyme.  Hence IMHO, they belong in this article and hence I have restored them.
* According to WP:MCBMOS and in particular protein structures, the background of protein crystal structure graphics should be white. In PyMOL, the recommended setting for a white background are:
 bg_color white
 set depth_cue=0
 set ray_trace_fog=0
* Chris Capoccia and I spent a lot of time adding  and  parameters to the  templates which provide useful link for readers of this article.  You should be able to use these as is and not replace them with less functional templates.  Thanks.  Boghog (talk) 20:25, 2 March 2016 (UTC)
thread_title:  Expansion
Talk:Guanylate cyclase

message: After the 7th International Conference on cGMP (2015, Trier, Germany) a committee came together to suggest a uniform name for the guanylate cyclases.
This committee suggested to the scientific society to use "guanylate cyclase" as the official name, not least to follow IUBMB nomenclature and references in FDA approved drugs.
According to IUBMB the accepted name is "guanylate cyclase", the other names are "alternative".
http://enzyme.expasy.org/EC/4.6.1.2
http://www.chem.qmul.ac.uk/iubmb/enzyme/EC4/6/1/2.html
Accordingly the name should be changed throughout the whole document.
Furthermore, the article should be moved to "Guanylate cyclase".
MosesMaWo (talk) 13:36, 20 April 2017 (UTC)
thread_title:  Change to "Guanylate cyclase" (throughout article, including Headline/source)
Talk:Heme oxygenase

message: New Wikipedia user here, not sure if this is the appropriate forum to express this, but I would like to see if someone who knows a bit about this enzyme could add in this article what organelle the degradation of heme occurs in. Kirligross (talk) 23:31, 9 December 2013 (UTC)
thread_title: Untitled

message: I searched haem oxygenase and it did not redirect to this article. Should this be a redirect? --Marshmellis (talk) 13:14, 11 September 2008 (UTC)
replies: text: Created the redirect. --Marshmellis (talk) 13:44, 30 September 2008 (UTC)
thread_title:  Haem oxygenase
Talk:Hexosaminidase

message: OK. Now I clearly understand what the confusion is about.  HEXA is a gene that encodes the alpha subunit while HEXB is a gene that encodes the beta subunit.  In other words, HEXA ≠ β-hexosaminidase A.  Rather the β-hexosaminidase A isozyme is a heterodimer composed of subunits encoded by the HEXA and HEXB genes while β-hexosaminidase B is a homodimer of beta subunits encoded by the HEXB gene.  Since the material that you are adding is about the β-hexosaminidase A isozyme, this material is much more appropriate for the hexosaminidase article which contains information about both subunits that comprise the α/β heterodimer while the HEXA article only contains information about the alpha subunit (and by extension only the α/α homodimeric isozyme "S"). Boghog (talk) 20:51, 11 December 2009 (UTC)
thread_title:  Clarification
Talk:Kate Douglas Wiggin

message: I stated in this article that Kate's house, Quillcote, is now the town library.  I had proper sources for the statement.  Someone twice changed this to "near" the town library.  I asked for a source; one was eventually offered, but the link is dead.  I have contacted the selectmen's office, and the secretary forwarded my inquiry to the librarian, who replied that "Kate Douglas Wiggin founded the Salmon Falls Library in 1911. It's located in a building that was a originally a tea house, then in 1911, the upstairs became a town library while the downstairs remained a tea house used for social gatherings. Eventually the whole building was used as a town library and continues as Hollis Maine's municipal library. Quilcotte was Kate's summer home and is located just around the corner from the Salmon Falls Library."  So the other person knew what he/she was talking about, and my sources were wrong.  J S Ayer (talk) 16:55, 28 October 2010 (UTC)
thread_title:  and the town library 

message: I've come across information about Wiggin's position as an anti-suffragist. I'm planning on adding that to this article.ScoutHarris (talk) 16:22, 27 August 2019 (UTC)
thread_title:  Anti-suffragism