Talk:Omeprazole

message: This section is actually describing clinical pharmacokinetics. Needs to describe mechanism of the drug, e.g. proton pump inhibitor. Receptor binding, etc. Times to onset, duration, peak effect are kinetic parameters. 121.75.48.151 (talk) 18:51, 18 March 2016 (UTC)
thread_title:  Pharmacodynamics 

message: "Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver. Identified metabolites are the sulfone, the sulfide, and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 80% of an orally given dose is excreted as metabolites in the urine, and the remainder is found in the feces, primarily originating from bile secretion."
This should be more specific. And a source is missing!
"CYP2C19 is the principal enzyme that metabolizes omeprazole to inactive metabolites."
source: https://www.ncbi.nlm.nih.gov/books/NBK100895/
--85.176.29.147 (talk) 19:55, 28 March 2018 (UTC)
thread_title:  Cytochrome P450 system 

message: In 'Pharmacology' a CH3 group is added to the pyridine structure.
Is this (unmentioned) CYP-Metabolisation or an error?  —Preceding unsigned comment added by 88.68.176.11 (talk) 20:01, 14 November 2010 (UTC)
replies: text: I agree: the extra methyl group on the pyridine looks very dodgy to me: it either needs to be commented on in the text and on the arrow (eg action of P450) or removed, but the source diagram has no attribution. 2001:630:206:FFFF:0:0:3128:A (talk) 17:07, 10 April 2013 (UTC)
replies: text: Confirming from patent EP 1603537 A2 Figure 1 ( http://www.google.com/patents/EP1603537A2?cl=en ) the lack of additional methylation at the 6- position in vivo. The diagram needs to be fixed  81.141.92.246 (talk) 20:06, 10 April 2013 (UTC)
replies: text: I have now fixed the image.  -- Ed (Edgar181) 13:36, 15 April 2013 (UTC)
thread_title:  CH3-Group added? 

message: In the article it mentions that Omeprazole is available in countries over the counter, yet no references, or names of countries where this is the case are provided.62.31.151.148 (talk) 16:48, 31 May 2009 (UTC)
thread_title: References

message: Should there really be like 100 brand names? I would assume the original brand name should be in the article, but not a gigantic list of every countrys' name for it.  —Preceding unsigned comment added by 69.205.97.220 (talk) 07:13, 28 January 2009 (UTC)
thread_title: Ridiculous brand names

message: I removed the comment about Salmonella, because it doesn't usually infect the upper gastrointestinal tract does it? Also, PPIs don't completely stop gastric acid secretion. Techelf 11:55, 27 Jun 2004 (UTC)
thread_title: Older entries

message: Does anyone know of any side effects? --204.49.34.2 12:41, 15 June 2007 (UTC)
replies: text: Will add to the article. Fvasconcellos (t·c) 13:26, 15 June 2007 (UTC)
replies: text: Added. Fvasconcellos (t·c) 01:36, 17 June 2007 (UTC)
thread_title: Side effects

message: Would it be unethical to mention in this article how good this drug is at treating the common alcohol 'hangover'? One of these the night before and then another in the morning and I'm right as rain. 81.106.138.53 (talk) 22:10, 1 January 2008 (UTC)
thread_title:  Hangover 

message: I have noticed that Omeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. In fact, these other pages make reference to the fact that using Omeprazole with these drugs can lead to heightened serum levels due to their shared hepatic clearance mechanisms. I think this information should be included in this article. Please include with a primary source. --1000Faces (talk) 16:18, 1 December 2009 (UTC)
replies: text: Done. Don't forget that secondary sources are preferred over primary sources. Fvasconcellos (t·c) 18:53, 1 December 2009 (UTC)
thread_title:  Interactions? 

message: http://img440.imageshack.us/img440/7695/scan033w.jpg  —Preceding unsigned comment added by Muleattack (talk • contribs) 01:00, 10 October 2010 (UTC)
thread_title:  scan of instructions provided with drug 

message: Has anybody heard of constipation being a side effect for this drug?Chocom (talk) 14:18, 17 January 2011 (UTC)
thread_title:  Constipation as a side effect? 

message: In Bangladesh Apex Pharma Limited also marketed omeprazole under the brand name "Aspra" which is a very good medicine
190.212.31.1 (talk) 05:10, 15 June 2011 (UTC)
replies: text: I removed the "which is a very good medicine" part.  -- Ed (Edgar181) 11:07, 15 June 2011 (UTC)
thread_title:  This shouldn't belong in here, right? 

message: Which works better, omeprazole or zantac?  — Preceding unsigned comment added by 67.58.92.76 (talk) 21:56, 6 June 2013 (UTC)
thread_title:  Which works better? 

message: Could someone more experienced than me edit the Interactions section for this medication? It has SERIOUS grammatical issues, but I don't want to change anything, because I'm not sure if the information is correct, either. Help!  — Preceding unsigned comment added by 69.169.139.88 (talk) 17:53, 9 November 2013 (UTC)
thread_title:  Interactions 

message: Anecdotal - Lucky me!  I ended up in the emergency room with severe abdominal pain, dehydration, uncontrollable nausea and retching after being prescribed with this med. Initially, I was simply uncomfortable and thought it was a stomach bug. But five weeks later and 15 pounds lighter I figured out that my problems began three days after taking this med.  The package insert states that these side effects are more common in those who take the drug when compared with placebo.  Two days after I stopped taking this med, my symptoms disappeared.
bpage (talk) 23:43, 29 March 2014 (UTC)
thread_title:  More About Side Effects 

message: It has been verified that Warfarine is metabolized partly or fully by the enzyme CYP3A4. Roshu Bangal (talk) 18:41, 23 August 2015 (UTC)
thread_title:  Warfarine and CYP3A4 

message: The structures on the right side of the "chemistry" sections have phenyl instead of pyrimidine groups  — Preceding unsigned comment added by 66.243.219.231 (talk) 15:47, 12 September 2017 (UTC)
replies: text: I have removed the image for now.  I'll create a replacement shortly. -- Ed (Edgar181) 15:44, 17 July 2018 (UTC)
thread_title:  Structure Error 

message: "Microscopic Colitis Associated With Omeprazole and Esomeprazole Exposure"
Wilcox, Gilbert M. MD*; Mattia, Anthony R. MD†
Journal of Clinical Gastroenterology 43(6):p 551-553, July 2009. | DOI: 10.1097/MCG.0b013e31817d3fa1
https://journals.lww.com/jcge/Abstract/2009/07000/Microscopic_Colitis_Associated_With_Omeprazole_and.8.aspx
Thank you for your time, Wordreader (talk) 21:57, 17 June 2023 (UTC)
thread_title:  Another possible side effect = Microscopic Colitis.