Talk:Psilocin

message: Manna is teonanactl, they are one and the same. I view serotonin to be more of a hallucinogen than psilocin, because with serotonin one is tricked into believing that the world is a much simpler place than it really is ;) Seek manna, God Bless.
This is a simplistic understanding of the serotonin system.  Serotonin receptors' primary roles in the body are not psychoactive at all.  Serotonin regulates a number of bodily functions, from breathing to smooth muscle contraction in the intestines.  Serotonin also remains active at 5HT2a receptors while experiencing a psychedelic; psilocin does not 'replace' serotonin while it's active, it merely shares a receptor site.  The only psychoactive experience I can think of that is linked directly to increased serotonin activity is MDMA, a psychedelic in its own right that certainly doesn't "trick [us] into believing that the world is a much simpler place than it really is."
With all due respect, I think it's your ungrounded approach to psychedelic research that makes the world seem like a simpler place than it really is.  Psilocin isn't some magical spirit compound; it's one of hundreds of known distinct 5HT2a partial agonists, each with wonderful and unique effects.  By deciding you've learned all there is to learn about this subject without even looking to the empirical evidence, you've done yourself a disservice.  Don't confuse science with empirical reductionism; it's perfectly possible to believe psychedelics are an important 'gateway to the soul' with much to teach us as individuals and as a species, while remaining fully grounded in empirical evidence.  In fact, it's an amazingly exciting field.  Do some reading - the truth is far more weird and wonderful than your simple mythology.  —Preceding unsigned comment added by 99.129.135.10 (talk) 22:39, 31 August 2010 (UTC)
thread_title: My personal belief

message: Although everyone spells it Psilocin technically there was a movement in the scientific community in the '70s to homoginize the naming structure of thes indoles (which are amines/alkaloid) by having an "e" at the end. I know this really is trivial as it essentially did not work we still spell it without the added "e" but in the science world is should officially be "psilocine" and "psiloybine"... I think we just don't like the way it looks though, I know I don'! (Compare mescaline, dimethyltryptamine these are amine <-- see the e?) I don't know it's all lame names for something much cooler.
"Technically" that movement failed.  Look in any reputable medical text that addresses the topic and you'll see psilocin, not psilocine.  The common name is of little concern to science, anyway; any serious scientific study into the compound would most likely refer to it by its IUPAC name: 4-Hydroxy-N,N-dimethyl-tryptamine.  Anything else is glorified drug slang, really.  —Preceding unsigned comment added by 99.129.135.10 (talk) 22:47, 31 August 2010 (UTC)
thread_title: Minor Correction

message: Does anyone know the chemical action of psilocin once in the brain?  Specifically which parts it affects (stimulation, inactivation, etc.) Sequoyah 07:12, 27 February 2006 (UTC)
thread_title:  neurochemistry? 

message: It says that psilocin is an agonist for certain hydroxytryptamine receptors in one part of the article with a citation, but then says citation needed when it says it mimicks serotonin.  The first citation covers this, an agonist activates a receptor.  It is admittadly a redundant comment added in by someone with a limited understanding though.24.65.42.159 (talk) 22:19, 24 October 2008 (UTC)
thread_title: Citation Needed?

message: Is it just me or doesn't it seem like the 3d model of the psylocin compound doesn't contain or show the hydroxyl group attached to the benzene ring. Did someone mistakenly posted a DMT picture instead of psilocin?--Deus911 17:14, 22 April 2011 (UTC)
thread_title: 3d model of psylocin

message: Psilocybin is rapidly dephosphorylated in the body to psilocin which acts as a 5-HT2A, 5-HT2C and 5-HT1A agonist or partial agonist. Psilocin exhibits functional selectivity in that it activates phospholipase A2 instead of activating phospholipase C as the endogenous ligand serotonin does.
There is this statement followed by a citation. The citation is a paper on "functional selectivity" and doesn't mention psilocin at all. So this is a wrong citation and I am going to remove it.
This is the paper that was cited: Functional Selectivity and Classical Concepts of Quantitative
Pharmacology  — Preceding unsigned comment added by 130.226.104.3 (talk) 15:42, 12 January 2017 (UTC)
thread_title:  Psilocin pharmacology 

message: I have been using clozapine for several months now (200mg daily), and have learned that it diminishes the psychoactive effect of psilocybin. I have failed to gather data on how long i should cease clozapine in order to have a magic mushrooms trip..? --Namaste@? 13:52, 24 January 2019 (UTC)
thread_title:  psilocybin and clozapine  

message: I've encountered a publication (Ray, 2010)  claiming that psilocin binds to D1, D3 more stronger than to 5H2A, 5HT2C.
according to this review,  it would be like that:
5HT2B>5HT1D>D1>5HT1E>5HT1A>5HT5A>5HT7>5HT6>D3>5HT2C>5HT1B>5HT2A.
can somebody take a look Mekatra (talk) 22:01, 4 April 2023 (UTC)
thread_title:  no signifcant effect on dopamine receptors?