Talk:Macrophage

message: This isn't coherent at all. - Cymydog Naakka 11:22, 5 Jan 2005 (UTC)
thread_title: Cleanup!

message: Is each macrophage a white blood cell? -- postglock 15:52, 31 August 2005 (UTC)
thread_title:  But what are they? 

message: What is the proper pronunciation of "macrophage"? I have heard it pronounced as "macro-phayge" as well as "macro-phawge". Is the difference regional, or simply in error?
:The former is the most common by far. JFW | T@lk 00:27, 10 March 2006 (UTC)
thread_title:  Pronunciation? 

message: I don't know much about the projection of macrophages, but is that macrophage actually trying to get two particles in one go? The directions of the "arms" looks more like it is focussing on the one "straight in front". // habj 10:40, 9 October 2006 (UTC)
thread_title:  Image caption 

message: -There is not enough information about the maturation process from monocyte to macrophage. —The preceding unsigned comment was added by Owz182 (talk • contribs) 15:36, 2 January 2007 (UTC)
thread_title:  "A Series of changes" 

message: Isn't there a couple accepted abbreviations for macrophages? like M(then a greek letter?).  What are they? —The preceding unsigned comment was added by 207.151.241.4 (talk) 01:18, 3 February 2007 (UTC)
thread_title: need abbreviations that professors use for macrophages

message: There appears to be a bug (reported) in the Wikimedia Player that returns an error when "Watch in browser" is attempted from the link in the article. However, the Watch-in-browser (Play-in-browser) feature does appear to work from the link provided on the image description page (i.e. the "(file info)" link).--DO11.10 18:37, 21 June 2007 (UTC)
thread_title:  A note about the videos 

message: My IRC nickname (or one of them, at least) is ANGRY_MACROPHAGE. I keep having to explain what an Angry macrophage is. Could someone please add a section to this article explaining it so I don't have to? Raul654 23:46, 1 July 2007 (UTC)
thread_title: Request

message: The page for "giant cells" redirects to the page for "macrophage". I don't think this is a good idea. There are other "giant" cells in the body. Some multi-nucleate cells form as a result of disease, some form during implantation of the blastula during pregnancy; muscle cells could be considered "giant" (so could neurons). The "giant cells" page should probably be a disambiguation page instead.
ajp (talk) 19:03, 8 February 2008 (UTC)
thread_title:  Redirection from giant cells 

message: Does anyone know where
"Macrophages can digest more than 100 bacteria before they finally die due to their own digestive compounds."
came from?
Shoko Seike  —Preceding unsigned comment added by Timtamholic (talk • contribs) 01:07, 22 August 2008 (UTC)
thread_title:  Reference? 

message: The 24 July 2008 edition of Nature, which has a whole section on inflammation, includes the following (p. 433)
Tissue-resident macrophages constitute 10-15% of most tissues, and their functions extend beyond host defence and the removal of apoptotic cells. Examples are control of the turnover of epithelial cells, regulation of metabolic activity of adipocytes and remodelling of bone (which is carried out by osteoclasts).
Unless I am misunderstand -- and my understanding is only that of an interested amateur -- the Wikipedia article does not mention those functions, though it hints at related functions. However, I lack the expertise to add them to the article. Perhaps someone else can assist ...  —Preceding unsigned comment added by 66.92.53.49 (talk) 23:12, 7 September 2008 (UTC)
thread_title:  functions of macrophages 

message: I can't help but point out that the very first thing you spot in the article is the word NEURON on the right side on top of the photo. I think this is very misleading. although they DO have some function in close proximity with PNS neurons, they are by far not as closely associated with neurons and neuroanatomy as it is being convayed. Immunity would be a more suitable word...Andrei A A (talk) 12:28, 29 May 2009 (UTC)
replies: text: Resolved. Thank you--DO11.10 (talk) 18:56, 29 May 2009 (UTC)
thread_title:  '''Neuron?''' 

message: I found the sentence below in the lead. As the lead is there to give an accessible overview of the subject, this seems a bit too specific to me. I'd like to hear some input from others before doing anything with it.
"They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining."
--JorisvS (talk) 19:57, 9 January 2010 (UTC)
thread_title:  Lead section 

message: While this section is interesting and provides useful information, much of it reads like an abstract.  In particular, the material following
:A study conducted in 2006 showcased macrophage influences on muscle repair of soleus muscle on mice [11]...
could be condensed to one or two sentences since details of a single experiment are irrelevant within the scope of the article.  I'm not qualified to make such changes and will leave it to someone familiar with the material.
-- Jimmy Hers (talk) 00:49, 3 October 2012 (UTC)
thread_title:  Muscle Regeneration 

message: I check pages listed in :Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of :Macrophage's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "Santoro":
From Wound healing: 
From Isothermal microcalorimetry: 
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 06:11, 5 October 2013 (UTC)
replies: text: Fixed ? - No Santoro ref any longer - Rod57 (talk) 11:38, 5 August 2017 (UTC)
thread_title:  Orphaned references in [[:Macrophage]] 

message: Substituted at 22:45, 29 April 2016 (UTC)
thread_title: Assessment comment

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thread_title:  External links modified 

message: It would be great if the Lifecycle section could be updated/expanded to mention the M1 & M2 phenotypes &/or the circulating? macrophages and the tissue resident subtypes. eg do M1 and M2 arise from different cell types or from different activations (clarify) of a single cell type ? - Rod57 (talk) 11:17, 5 August 2017 (UTC)
thread_title:  Lifecycle section could be expanded 

message: Signal-regulatory protein alpha says that CD47 binding to the SIRP-a on some/all macrophages inhibits their phagocytic behaviour. Could mention somewhere here ? - Rod57 (talk) 12:44, 5 August 2017 (UTC)
thread_title:  Should mention inhibition via Signal-regulatory protein alpha 

message: Hello fellow Wikipedians,
I have just modified 3 external links on Macrophage. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20051031002654/http://recon.stanford.edu/Articles/LorenzWH.pdf to http://recon.stanford.edu/Articles/LorenzWH.pdf
*Added archive https://archive.is/20130112235506/http://fedde.org/hiv-mac to http://fedde.org/hiv-mac
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thread_title:  External links modified 

message: This section seems like an afterthought with many holes after a list of related diseases was incorporated.  It could use additional information on each disease or simply the removal of some if further information is not available.Immcarle53 (talk) 03:03, 16 January 2018 (UTC)
thread_title: Disease

message: What follows is a list of potential sources and information to add to this page.  If anyone has any suggestions or concerns about these articles then please feel free to reply.
Bibliography
Ali, R. A., Wuescher, L. M., Dona, K. R., & Worth, R. G. (2017). Platelets Mediate Host Defense against Staphylococcus aureus through Direct Bactericidal Activity and by Enhancing Macrophage Activities. J Immunol, 198(1), 344-351. doi:10.4049/jimmunol.1601178
Goldberg, E. L., Smithey, M. J., Lutes, L. K., Uhrlaub, J. L., & Nikolich-Zugich, J. (2014). Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol, 193(2), 757-763. doi:10.4049/jimmunol.1400188
Grimm, M. J., Vethanayagam, R. R., Almyroudis, N. G., Dennis, C. G., Khan, A. N., D'Auria, A. C., . . . Segal, B. H. (2013). Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol, 190(8), 4175-4184. doi:10.4049/jimmunol.1202800
Hansen, F. C., Stromdahl, A. C., Morgelin, M., Schmidtchen, A., & van der Plas, M. J. A. (2017). Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria. Front Immunol, 8, 843. doi:10.3389/fimmu.2017.00843
Kim, J. H., Lee, J., Bae, S. J., Kim, Y., Park, B. J., Choi, J. W., . . . Yuk, J. M. (2017). NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection. Sci Rep, 7(1), 6361. doi:10.1038/s41598-017-06610-4
Leopold Wager, C. M., & Wormley, F. L., Jr. (2014). Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol, 7(5), 1023-1035. doi:10.1038/mi.2014.65
Verma, A., Kroetz, D. N., Tweedle, J. L., & Deepe, G. S., Jr. (2015). Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal Immunol, 8(2), 380-389. doi:10.1038/mi.2014.75
Weiss, G., & Schaible, U. E. (2015). Macrophage defense mechanisms against intracellular bacteria. Immunol Rev, 264(1), 182-203. doi:10.1111/imr.12266
Immcarle53 (talk) 20:02, 28 January 2018 (UTC)
replies: text: I can in no way speak to any of the technical aspects but you absolutely have the right idea. Please go ahead and be bold and if their are any issues I'm sure they will be easily handled. Thanks for working on the wiki! Gabriel syme (talk) 07:55, 29 January 2018 (UTC)
thread_title: Bibliography

message: — Assignment last updated by Immcarle198 (talk) 16:48, 28 January 2023 (UTC)
thread_title: Wiki Education assignment: Immunology 2023

message: Should the second paragraph start with “these phages” or just “macrophages” instead of “these larges?” It looks like autocorrect failure. James.d.carlson (talk) 12:34, 16 February 2023 (UTC)
replies: text: Just go ahead an correct it. Looks weird to everyone.  Jonnyboy5 (talk) 08:38, 22 February 2023 (UTC)
thread_title:  what are “larges?” 

message: I am sympathetic to the need to present different measurement systems, but in science even in the US, the inch is not used and is not very useful as a unit of measurement when compared to microns. I would suggest removing the reference to inches, since it doesn't really add anything to the article. Jonnyboy5 (talk) 08:40, 22 February 2023 (UTC)
thread_title:  Inches 

message: The article is lacking discussion of macrophage expression of galectins, such as galectin-3 and the role in disease.  There are many research studies that implicate macrophages in disease via the galectin-3 pathway. 107.194.133.235 (talk) 02:55, 29 November 2023 (UTC)
thread_title:  Expression of galectins 

message: — Assignment last updated by JJ,1of1, AUS (talk) 18:04, 14 March 2024 (UTC)
thread_title: Wiki Education assignment: Academic Writing II