lflage/wiki-talks huggingface dataset:
Talk:Filgrastim

message: I notice a flag for citation needed under the contraindications section. I don't really know how to do references, but my nursing textbook says the same thing; that peoplw sensitive to e-coli derived proteins should not take filgrastim. Eyknough (talk) 04:50, 27 October 2009 (UTC)
thread_title: citation needed

message: eg When FDA and EU approved - Rod57 (talk) 14:06, 10 November 2015 (UTC)
thread_title:  Need info on clinical trials and approved indications 

message: How are the different brands (and the biosimilar) made ? Are the the various brands made in the same factory or with the exact same recombinant eColi strain, and purified the same ? How does the biosimilar Zerxio differ in structure and manufacture ? - Rod57 (talk) 15:09, 15 June 2016 (UTC)
thread_title:  How are the different brands and the biosimilar made 
Talk:Darbepoetin alfa

message: Moleculer weight = 37 kDa  —Preceding unsigned comment added by 125.16.17.1 (talk) 06:34, 10 November 2009 (UTC)
thread_title: Untitled
Talk:21-Hydroxylase

message: Fixed it - I think.
Dr. BeingObjective (talk) 18:41, 27 November 2023 (UTC)
replies: text: I think that you didn't mess anything. It is just Wikipedia formats text that way. Maxim Masiutin (talk) 19:14, 27 November 2023 (UTC)
thread_title:  Pseudogenes 

message: There is a lot in this section - and to me - is leans to CLOP - 
It contains an evolutionary conserved core of a four α-helix bundle, two additional alpha helices, two sets of β-sheets, and a heme cofactor binding loop. 
Each subunit in the human enzyme consists of a total of 13 α-helices and 9 β-strands that folds into a triangular prism-like tertiary structure. The iron(III) heme group that defines the active site resides in the center of each subunit. 
The human enzyme binds one substrate at a time. In contrast, the well-characterized bovine enzyme can bind two substrates. The human and bovine enzyme share 80% amino acid sequence identity, but are structurally different, particularly in loop regions, and also evident in secondary structure elements. BeingObjective (talk) 19:51, 27 November 2023 (UTC)
replies: text: I have no idea on how it passed GA with that text. If I knew how to write this text simpler, I would have done that. I agree that the audience is not a wide audience. Maxim Masiutin (talk) 20:14, 27 November 2023 (UTC)
thread_title:  This section - if you want to expand - clarify make accessible - needs to think of the target audience.  

message: According to Wikipedia:Manual_of_Style/Dates_and_numbers, the editors should refrain from altering the style of elements such as date format, units, and so on, within an article unless there is a significant reason that is not merely a preference for a different style. Engaging in revert-wars over optional styles is not acceptable. If a consensus cannot be reached through discussion regarding the style to be used in an article, the style established by the first major contributor should be respected. My understanding is that this rule also applies to reference formats. Maxim Masiutin (talk) 21:38, 3 December 2023 (UTC)
thread_title:  Reference style
Talk:8-Hydroxyquinoline

message: :I support the proposed merge. --Arcadian 23:34, 25 August 2007 (UTC)
replies: text: I went ahead and merged the bit of content from oxyquinoline. --Ed (Edgar181) 13:27, 27 August 2007 (UTC)
thread_title: Untitled

message: So I got this stuff at the store, New Skin Liquid Bandage. it basically is a spray that it says to not use on wounds, burns, etc...kinda making its applications limited. And you cant use it on areas that are sensitive since it needs a secodn application to get off. It smells like acetone and says nail polish remover will deactivate it.
So um. Yeah, I have no idea, just that this is its main ingrediant. And it smells bad and is painful and doesnt do what it should. And cost me $8. 74.128.56.194 (talk) 00:35, 16 December 2010 (UTC)
replies: text: What does it say you CAN use it on?  The smell is most likely from the solvent part, I would guess, not the 8-hydroxyquinoline, which is relatively involatile. Walkerma (talk) 22:22, 30 December 2010 (UTC)
thread_title:  "new skin" 
Talk:CYP2C19

message: Potentially it's dangerous misinformation stating that carbamazepine is an inducer of the enzyme. It's true that the given source calls it an inducer, but that source (https://en.wikipedia.org/wiki/CYP2C19#cite_note-Flockhart-16) doesn't cite its source for that information (it does for most other things) and everything I'm finding is that if anything it is an *inhibitor* of the enzyme: Graatch (talk) 13:22, 30 August 2019 (UTC)
thread_title:  Dubious
Talk:List of majority-Hispanic or Latino counties in the United States

message: This has two Starr counties, and it seems to be missing Medina county Ngfsmg (talk) 14:17, 5 December 2021 (UTC)
replies: text: Thank you, I have fixed the errors now -- Abbasi786786 (talk) 03:50, 12 December 2021 (UTC)
thread_title:  Texas counties
Talk:Hemerythrin

message: Haemerythrin should redirect here or the page should be renamed if haemerythrin is the international spelling (it's certainly the spelling used by the people who made up the English language i.e. the English). I don't have an account so I can't create the re-direct page.  —Preceding unsigned comment added by 94.193.93.76 (talk) 14:47, 28 April 2009 (UTC)
thread_title:  Haemerythrin
Talk:Nalewka

message: I went throught and added links to all the pages for types of nalewka listed but most have not pages (only three do).  If someone knows more about this please create pages for the rest.  To make this easy just click on any of the links that are red.
Among the common main ingredients are haw (głogówka),  Cornus mas (dereniówka), juniper (jałowcówka)Technically gin is also a nalewka , ginger (imbirówka), green Persian walnut (orzechówka), cherries (wiśniówka), wormwood (piołunówka), anise (anyżówka), apricots (morelówka) and many more. Among the nalewkas are also mixtures of alcohol with other liquids, such as honey-based krupnik, coffee-based kawówka, and porterówka made of Porter beer.
Scaper8 19:39, 26 April 2007 (UTC)
thread_title:  We Need to Create Pages
Talk:Evening

message: There's been some backing and forthing with recent edits. I see that some of the recent edits have been supported by cites to reference.com, but that's a third-party source that supposedly derives its information from other sources (sort of what WP does) and it's written in a fairly informal and non-authoritative-seeming way. Are other editors happy with citing reference.com? — jmcgnh(talk) (contribs) 09:40, 1 January 2018 (UTC)
replies: text: I would get rid of the reference.com refs but keep the Oxford ref. Here is one more:  but as it stands the article could be a candidate for deletion per WP:DICDEF. Your thoughts? --NeilN talk to me 18:29, 1 January 2018 (UTC)
replies: text: I've restored some refs, but excluded reference.com.  If editors are going to continue to argue over the timings (as they've been doing for ten years), then perhaps it would be best deleted.  Is there much more we can say about the subject?  It's hardly more than a stub at present.  Dbfirs 18:40, 1 January 2018 (UTC)
replies: text:  Whatever timings appear in the article are fine by me as long as they're sourced. I felt that Teletabi's deletions were not accompanied by valid/understandable reasons so that's why I reverted. Perhaps we could pattern the article based on Morning? --NeilN talk to me 18:49, 1 January 2018 (UTC)
replies: text: Yes, the article on morning is worth keeping.  Would you like to make the improvements to this article?  Dbfirs 18:58, 1 January 2018 (UTC)

text: As has already been explained to you, no law is required for articles on the English Wikipedia.  We rely on what the best references say.  This article certainly needs improving, but not by removing referenced facts.  Oxford online is usually considered a good source for the meaning of words in English, and it states 6 p.m. as a possible approximate starting time.  I'd be happy to remove the 7 p.m. and clarify that no exact time is implied. The English article already says "There is no precise definition in terms of clock time."  Dbfirs 16:49, 3 January 2018 (UTC)
thread_title:  Reference.com as source? 

message: A conventional expression used at meeting or parting in the evening. --Backinstadiums (talk) 16:03, 9 May 2021 (UTC)
thread_title:  good evening 

message: Can we all just agree 5pm is the answer for start time
Collins is a great source 99.234.150.50 (talk) 21:38, 12 December 2021 (UTC)
replies: text: you make a great point. 5pm is the start of evening 66.244.218.226 (talk) 03:35, 26 August 2023 (UTC)
thread_title:  5pm 

message: Google say "the period of time at the end of the day, usually from about 6 p.m. to bedtime." It says it's from Oxford Languages, which seems reliable, but there doesn't seem to be a link to the specific dictionary page. Benjamin (talk) 17:55, 18 October 2023 (UTC)
thread_title:  Definition
Talk:Montrain

message: The CN division certainly seems notable, but although I'm not completely familiar with the application of WP:WEB, I would be surprised to see that the discussion group is. I suggest that the section about the discussion group be removed, so that the article will be about the CN division only. //74.56.91.108 19:41, 26 April 2007 (UTC)
thread_title: Notability

message: Is Montrain still running the show? AMT purchases Deux-Montagnes rail line from CN for $92 million. Peter Horn User talk 15:10, 16 April 2014 (UTC)
thread_title:   Update needed
Talk:List of Record of Lodoss War characters

message: I don't really have all the information to make a good edit, but it seems that the list could use some work. Characters like Etoh and Woodchuck are definitely NOT main characters. Spark, one of the most major characters involved in the entire storyline, isn't even listed at all! 74.32.123.90 (talk) 10:44, 21 February 2009 (UTC)
thread_title: Minor characters
Talk:Debden tube station

message: Is the bit about the loop correct? I was there today and watched the operation of trains that were being turned back to London because of signal failure onward to Epping. I think the correct term is 'turnback siding'. A loop would imply that the trains can run round the  loop without reversing which I don't believe is the case here. Sangwine 19:43, 26 April 2007 (UTC)
thread_title: Loop

message: I have corrected the location to show that "Debden Station" is in Loughton. This information is correct as confirmed by the station's address. Please do not alter this with incorrect misinformation.(Spymo (talk) 17:47, 20 March 2013 (UTC)
thread_title: Location
Talk:Calcium-activated potassium channel

message: I think this page could be benefited by further explanation of why certain channels are still grouped in the Calcium activated Potassium channel family when they are activated by other ligands, such as pH or Sodium as the article states. I also think it would be beneficial to have some information on the mechanism behind the opening of these channels. Linde8 (talk) 03:29, 9 October 2015 (UTC)
thread_title: Untitled
Talk:L-type calcium channel

message: Hello,
I have begun some editing on this page. Changes I've made:
# Added 'Structure' heading and wrote a sentence detailing the alpha subunit of the Calcium channel 
# Added some definitions: specefically, I added that L-type is "part of the high-voltage activated Calcium channel family"
# Made some revisions detailing L-type channel's involvement in the cardiac action potential and EC coupling  — Preceding unsigned comment added by Val damme (talk • contribs) 05:41, 30 November 2014 (UTC)
thread_title:  Major Edits Underway 

message: Hey,
I will be working on this page for the next month or so. A lot of the editing will be done in my sandbox, but I will start moving over the changes towards the end of the next month. Let me know if there is anything that we think we should add and I will study it to add it in.
ItnosoyI (talk) 17:29, 15 October 2019 (UTC)
thread_title:  More Edits to Come
Talk:Chloride channel

message: This page says that Chloride channels also conduct Bicarbonate Ions. I was wondering if these are the channels that exchange Chloride ions for Bicarbonate ions in red blood cells, or if they are related to these channels. It might be good to like those if they are related.Linde8 (talk) 03:48, 9 October 2015 (UTC)
thread_title: Untitled
Talk:B3

message: ----
The members of the boygroup B3 were from New York City. So I don't think you can call it a German band.. --Tintenherz12 19:48, 26 April 2007 (UTC)

message: B3: big booty becky
B. BA:badest bitches alive
BBBFG:big black friendly giant
BBC: Champa semau (talk) 21:06, 20 October 2017 (UTC)
thread_title:  support
Talk:Grand Aire Express

message: What about the Nov. 30, 2004 crash of their HFB-320 Hansa Jet at the Spirit of St. Louis Airport, Saint Louis, MO, killing the company president, who was at the controls of the plane? See: http://aviation-safety.net/database/record.php?id=20041130-1. This is not listed under Accidents and Incidents. Not being an editor myself, I thought I'd mention it here and let someone who is determine whether it merits including. It wasn't necessarily the pilot's fault, just for the record.  — Preceding unsigned comment added by 172.248.51.75 (talk) 23:37, 25 February 2015 (UTC)
thread_title:  Untitled 

message: The Safety and FAA oversight section was removed.  This improved the article and was well sourced.  
Reviewing the accidents and incidents section a pattern of unsafe behavior can be seen.  The safety and oversight section explains some the factors that created an environment capable of causing that many accidents and incidents.  
JimBob2u (talk) 04:30, 21 April 2020 (UTC)
thread_title:  Safety and FAA Oversight Section
Wikipedia talk:Requests for adminship/Retiono Virginian

message: Retionio Virginian's edit count is below
*Category: 15  
Help: 1  
Image talk: 2  
Image: 32  
Mainspace 953  
Portal: 6  
Talk: 45  
Template talk: 2  
Template: 37  
User talk: 756  
User: 274  
Wikipedia talk: 6  
Wikipedia: 278  
avg edits per page 1.61  
earliest 17:17, 24 January 2007  
number of unique pages 1498  
total 2407  
2007/1  328   
2007/2  499   
2007/3  955   
2007/4  625 
Fetched from Interiot's "Wannabe Kate" 
Simply south 19:51, 26 April 2007 (UTC)
Talk:Take Heart (Juice Newton album)

message: Until Tonight song credit
The 2000 EMI Music Special Markets album, Angel, which I own, lists McClintock and Parker as the songwriters for Until Tonight.  I found Steven McClintock pretty quickly, but I am less sure of Parker's identity.  My current guess is that it's Jim (James Ervan) Parker (he's worked the Alabama-Nashville TN scene during the right period), but I can't be sure.
Then I found this wiki page, which lists Tim James as co-writer -- another person entirely.  I did a quick search for the album Take Heart in an attempt to confirm songwriter credits for the song, "Until Tonight."  Sometimes an image of the album credits can be found.  EMI could have made a mistake; more and more the covers are done outside the US and spellcheck is not even always a priority. I am suspicious of the wiki credit, though, as all the credits on the wiki page for Tim James show credits from around the year 2000 onward, and this song came out about 20 years earlier. 
I've spent two days trying to find info on this song to verify lyrics and songwriting credit for my own library, to no avail. Does anyone have the original vinyl album Take Heart and can verify at least the last name on the songwriter credit? Thanks in advance. DTavona (talk) 22:09, 25 January 2014 (UTC)
thread_title:  Songwriter credits
Talk:Grand Canyon Airlines

message: This should be merged with Grand Canyon Scenic Airlines.Mirza Ahmed (talk) 02:58, 10 June 2019 (UTC)
replies: text: Yes MilborneOne (talk) 16:34, 10 June 2019 (UTC)
thread_title:  Merge proposal
Talk:Area codes 816 and 975

message: Kansas city has not had 7 digit dialing since the 90's. Probably before the 660 split. Kansas and Missouri can call each other as if they were in the sane LATA/RATE CENTER dispite being in different stares. Hence 816/913 is a psudo overlay separated by a state line. This is part of the reason the city itself hasn't needed an overlay within the rate center. Patrick (talk) 02:35, 21 March 2020 (UTC)
thread_title:  7 digit dialing
Talk:Lamprocles

message: Why is this a page? I thought bios had to be about people of note or interest. The only source we have about lamprocles says he was not notable. Delete?  — Preceding unsigned comment added by 2602:304:B1B8:6740:FD90:FCA4:CCBB:880A (talk) 05:16, 14 February 2015 (UTC)
Talk:IBC Airways

message: RE: Fleet size notations - Dear IP editor 74.166.134.114 and IBC Airways employee, 
::If you want to publish the fleet size and type specifics for IBC Airways, I suggest you use a 3rd party reference where the data are actually shown, such as American Airlines does.  http://en.wikipedia.org/wiki/American_airlines . (See notion number 86) You have simply set a notation to show another wikipedia article for "Flight International" as your reference. This construes the wikipedia definition of O.R. All we are privy too from the article is a magazine cover. Any further reversions will begin an Editing War and lock the IBC Airways article at the fleet size of 2. --XB70Valyrie (talk) 04:30, 10 May 2011 (UTC)
thread_title: Untitled
Talk:William H. Steele (United States Army officer)

message: Article edited. The sources do not indicate charges of a sexual relationship with the Iraqi woman. The charges are fraternization. The military definition of fraternization is not synonymous with sexual relations, and it is used as a catch-all to include all inappropriate relationships, sexual or otherwise.HealthySkepticism 14:48, 6 May 2007 (UTC)
thread_title: Untitled

message: A temporary subpage at User:Polbot/fjc/William H. Steele was automatically created by a perl script, based on this article at the Biographical Directory of Federal Judges. The subpage should either be merged into this article, or moved and disambiguated. Polbot (talk) 21:39, 5 March 2009 (UTC)
thread_title: Bot-created subpage
Talk:List of minor characters from The Mighty Boosh (live shows)

message: As part of the cleanup needed across all the mighty boosh pages, the information on this page needs to moved somewhere else. It should be on a page specifically about The Mighty Boosh live, I reckon. One thing this page isn't is a list. Tbone762 20:12, 26 April 2007 (UTC)
thread_title: Clean up
Talk:Μ-opioid receptor

message: There's a lack of info on this page. What type of receptor is this? What is the structure of this receptor? How does it signal downstream? What's the relationship/difference/importance between the subtypes?   —Preceding unsigned comment added by 137.43.95.210 (talk) 19:01, 4 February 2009 (UTC)
thread_title: lack of content

message: This is an interesting possibility that can be worked into the article if we can find some other citations:
 MeekMark (talk) 14:23, 13 November 2009 (UTC)
thread_title:  Genetic polymorphism 

message: This page was moved from "Mu Opioid receptor" to "M-opioid receptor". I object to this move, because the other opioid receptor subtype pages are not named in this way, and the "M" nomenclature is non-standard. Therefore, I am going to revert the move, to "mu Opioid receptor". Please note that we name delta Opioid receptor and kappa Opioid receptor the same way. --Tryptofish (talk) 21:23, 7 January 2011 (UTC)
thread_title:  Objection to rename 

message: I have added the propiram derivatives because it is only the matter of 2 sentences (including links) but things like nexeridine DID reach the market so does that metic inclusion? I put the viminol derivatives in the READ section and someone else added it to the article. Nexeridine overlays dextropropoxythene (and it's pyridyl derivatives) so it does provide a path for students to follow. Should it have a page?  — Preceding unsigned comment added by 81.99.74.135 (talk) 18:06, 11 September 2018 (UTC)
thread_title:  Inclusions 

message: Compare to δ-opioid receptor and κ-opioid receptor. This article does not have a list of ligands. Kimen8 (talk) 23:20, 10 December 2023 (UTC)
thread_title:  Ligands?
Talk:List of chemical classifications

message: I'm not a chemist, but this topic seems to me to be of enormous interest and importance. I'd personally put it as "top", Subject is a must-have for a print encyclopaedia (see Wikipedia:WikiProject Chemicals/Assessment, there seems to be no separate scale for WikiProject Chemistry). But surely it at least qualifies for "high", Subject contributes a depth of knowledge, rather than "mid", Subject fills in more minor details.
Currently  it's at "low", Subject is mainly of specialist interest. Surely not? Andrewa (talk) 18:51, 4 January 2014 (UTC)
thread_title: Importance
Talk:Sigma receptor

message: "Sigma receptors may induce hallucinogenic effects and also may be responsible for the paradoxical convulsions sometimes seen in opiate overdose."
Not σ-receptors are inducing these effects, their activation by an agonist ligand does; further, in the article, σ-receptors are defined as "non-opioid", yet the image on the right describes it as "sigma opioid receptors".--84.163.87.66 06:56, 28 April 2007 (UTC)
thread_title:  A receptor doesn't cause effects, its interaction with an ligand does. 

message: Wouldn´t it be better to express is like this: " Antidepressive Effects have been concluded."?----  —Preceding unsigned comment added by 91.96.45.250 (talk) 20:14, 9 June 2010 (UTC)
thread_title:  How can antidepressive effects be seen in mice? 

message: "However, pharmacological testing indicated that the σ-receptors were activated by drugs completely unrelated to the opioids, and their function was unrelated to the function of the opioid receptors. For example, phencyclidine(PCP), and the antipsychotic haloperidol may interact with σ-receptors. Neither phencyclidine nor haloperidol have any appreciable chemical similarity to the opioids."
PCP is a relatively strong mu opiate receptor agonist. It also actually does share some structural similarity to morphine and other opioids like pethidine and fentanyl. So does haloperidol. Maybe a good example would be fluoxetine, diphenhydramine, sertraline, or DHEA. (Although truthfully these all have a lot of structural similarity to active opioids.) Also I think the sigma classification is still being disputed. At some point maybe I will find some good examples of the sigma receptors still being referred to as opioid receptors. Mostly the common parlance is orphan receptor. Anyway, this is all minor. :) Good article.  — Preceding unsigned comment added by JasonSims1984 (talk • contribs) 04:42, 21 December 2014 (UTC)
replies: text: I've removed the more direct claims of this here, but the classification section is a poorly written mess filled with similar claims. I'd like to rewrite it but I'm having a hard time getting a good citation about the history of sigma receptors and their ligands and prototypical ligands being benzomorphans (or what the first discovered ligand was). The whole section is a mess and really needs to be rewritten. Towelbin (talk) 06:49, 30 March 2021 (UTC)
thread_title:  Slightly Inaccurate? 

message: It honestly took me over three minutes to understand what the lead sentence meant. Can this text be simplified?PNSMurthy  (talk) 05:54, 1 August 2020 (UTC)
thread_title:  Woah 

message: I think a link to SAS-1121 belongs somewhere in here. (Obviously the fact I'm trying to de-orphan that article is one reason for me thinking so.) It's a tool compound that was used in research on the σ_2 receptor. Musiconeologist (talk) 02:21, 7 March 2024 (UTC)
thread_title:  Tool compound selective for sigma-2 over sigma-1