Talk:Paternal age effect

message: Is there any part of the paternal age effect that belongs in Wikipedia? —Preceding unsigned comment added by Anniepema (talk • contribs) 
:It really needs to be peer-reviewed research which has been published in a reputable scientific journal. See Wikipedia:No original research. -Fsotrain09 17:31, 27 December 2006 (UTC)
thread_title:  Paternal Age 

message: as far as i can tell, hemophilia is a genetic disorder that's inherited through two recessive genes.  How the age of the father affects this, i don't know.  How would his age affect a gene he had in his DNA from birth?  —Preceding unsigned comment added by 167.7.17.3 (talk) 19:55, 27 August 2008 (UTC)
thread_title:  hemophilia 

message: The  tone of this article is strange for a medical article. Something like this "If my son or daughter was to ask..." isn't very scientific. Bhny (talk) 20:26, 24 December 2013 (UTC)
thread_title:  Neutral tone 

message: Definition
:MedicineNet.com lists two types of paternal age effects. The two types are autosomalmutations and an indirect paternal age effect from mutations on the X chromosome.  Definition of advanced paternal age.  Autism Risk Across Generations.  
Clinical implications
:MedicineNet.com also states that there is no universal definition of advanced paternal age, but does suggest that in the realm of genetic counseling, all men 40 yrs and older at the time of conception meet the criterion. 
Pathophysiology
:Commenting on the study of 78 Icelandic families,  Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K (2012). "Rate of de novo mutations and the importance of father's age to disease risk". Nature 488 (7412): 471–5. doi:10.1038/nature11396. PMC 3548427. .  Harry Fisch, MD,  clinical professor of urology and reproductive medicine at Weill Cornell Medical College of Cornell University, suggests that now men too have a reference point in decisions of advanced paternal age and risk for genetic defects. Father's Age Linked to Autism.The article cites that for women the age of 35 is a benchmark in determining the age of increasing escalation of genetic defect risks and that now men can assume a doubling of the mutation rate every 16 years.
Wilson.3308 (talk) 04:07, 30 September 2014 (UTC)
replies: text: I agree that Autism Spectrum Disorder and Bipolar Disorder are missing links to the Wiki pages in the Notable Conditions and Diseases section. Is a free full text available for your citation on the aneuploidy study? And caution, the word performed is not spelled correctly in your edit change. Wilson.3308 (talk) 04:01, 5 October 2014 (UTC)

text: I Thank you for the feedback. I've gone and corrected the error. I'm still trying to find the full text for the article.    — Preceding unsigned comment added by Collins.1128 (talk • contribs) 02:44, 15 October 2014 (UTC)
thread_title:  Suggestions 

message: :I would like to add the following image to the article to help portray the meaning and improve upon the page.Wilson.3308 (talk) 02:57, 11 October 2014 (UTC)
thread_title: Image

message: :As per my assignment, I have edited the previous "other conditions" section. It is now labeled (PAE) Disorders, mechanism, and other conditions. This edit lists the disorders collectively known as (PAE) disorders and briefly mentions the "Selfish Selection" mechanism as outlined by Goriely A, and Wilkie AOM (2013). Also, so as to not have the disorders listed twice, I have removed these (PAE) disorders from the long list of other conditions that follow. Wilson.3308 (talk) 00:49, 20 November 2014 (UTC)
thread_title: Edit

message: Refs need to be improved per WP:MEDRS. Doc James (talk · contribs · email) 06:16, 12 December 2014 (UTC)
thread_title: Article is poor

message: The two subsections on "Paternal mortality before adulthood of child" and "Fertility" are not really paternal age effects, in the sense that these two effects relate primarily to the father, not to the offspring. Delete or move to some other more appropriate Wiki article? Suggestions?  — Preceding unsigned comment added by 86.137.100.88 (talk) 09:55, 3 May 2015 (UTC)
thread_title:  Remove sections "Paternal mortality" and "Fertility"? 

message: May 2015  Doc James (talk · contribs · email) 16:20, 30 May 2015 (UTC)
thread_title: Recent review

message: might want to try this reference , its a Diabetes mellitus type 1 reference under Paternal age and outcome of offspring section  (should you have difficulty  use CTRL+f for word find) --Ozzie10aaaa (talk) 18:20, 1 June 2015 (UTC)
thread_title:  review /2010 / 

message: Hello fellow Wikipedians,
I have just added archive links to  on Paternal age effect. Please take a moment to review my edit. You may add  after the link to keep me from modifying it, if I keep adding bad data, but formatting bugs should be reported instead. Alternatively, you can add  to keep me off the page altogether, but should be used as a last resort. I made the following changes:
*Attempted to fix sourcing for http://ender.bu.edu/~tgardner/be209/lectures/12/articles/Crow.JF_NatRevGen_00.pdf
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—cyberbot IITalk to my owner:Online 13:27, 31 March 2016 (UTC)
thread_title:  External links modified 

message: The wholescale removal of primary research citations has been counterproductive here, at least where the basic mechanisms are concerned. WPMED requirements (i.e. review/textbook requirements) should apply only to medical research, not to biological mechanisms. The latter  research field (paternal age effect mechanisms, not medical outcomes) is too young and too small to have generated meaningful reviews let alone meta-analyses or textbooks.
The simplistic view implied here is that aging men accumulate DNA mutations as a result of DNA replication errors. And that these errors cause medical outcomes in the offspring.
The reality is that we are only just beginning to understand how many paternal DNA mutations are caused by environmental mutagens (and are thus not primarily related to age but to lifestyle etc.), and how many mutations are indeed introduced inevitably during cellular replication (and are thus a true aging hallmark).
The only case where we can distinguish this paternal aging effect from environmental effects is repetitive DNA mutations (telomers, minisatellites, microsatellites) and other insertion/deletion events (duplication leding to copy number variation, deletions), as these mutations can arise ONLY during replication. (The references for this simple fact have been deleted, presumably because they were not reviews).
The Goldmann et al. 2016 Nature paper for example has made this comparison, with revealing results. But again, it is not a review and presumably therefore was deleted.
Please go through the deleted sections and salvage material where appropriate, to make these points clear. Thanks. 65.153.177.214 (talk) 14:49, 22 August 2017 (UTC)
thread_title:  Fundamental misunderstanding: DNA replication errors versus DNA mutagens 

message: Hello fellow Wikipedians,
I have just modified one external link on Paternal age effect. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20100109185819/http://www.schizophreniaforum.org/for/curr/Malaspina/default.asp to http://www.schizophreniaforum.org/for/curr/Malaspina/default.asp
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 20:48, 20 September 2017 (UTC)
thread_title:  External links modified 

message: The whole article is full of weasel-words. Its sounds like something important is described but its not. Words like "low" have no meaning outside of the experts that know what is normal. One of the few (only?) exception is this sentence "odds ratio for low birthweight was approximately 1.1 at a paternal age of 20 and approximately 1.2 at a paternal age of 50". That is useful information. But statement such as: (regarding mental illness) "a twofold risk for younger fathers and a threefold risk for fathers >50 years old.". It means absolutely nothing if the base risk is not stated. Is it 3 times 0,00001% or 3 times 10% ?  — Preceding unsigned comment added by 2403:6200:8810:6239:942A:BD72:8D84:E6E1 (talk) 09:24, 22 October 2020 (UTC)
thread_title:  Weasel words 

message: I don't have time to integrate this at the time, but I think this is a good secondary source for the article: -Pengortm (talk) 22:18, 31 December 2020 (UTC)
thread_title:  Good secondary source to integrate