Talk:Sulbutiamine

message: Can someone that understands this better look at the 'mechanisms of action' section and fix the wording of this sentence?:
"Sulbutiamine is a thiamine derivative which has two different properties in comparison with vitamin B1 as a result of structural modification of free thiamine, namely opening of the thiazole ring, esterification of the alcohol groups and dimerization, with formation of a disulfide bridge." 209.63.116.205 (talk) 16:51, 2 October 2008 (UTC)
replies: text: I completely reworded that sentence and moved it to the article opening where it makes more sense. The structural characteristics of sulbutiamine should not be included in the "Mechanism of action" section unless a structure-activity relationship (SAR) is being discussed. Firewall62 (talk) 04:59, 23 December 2008 (UTC)
replies: text: I just revised the article again and removed the wordy discussion about the structural characteristics of sulbutiamine. Those characteristics are obvious when comparing the structures of sulbutiamine and thiamine. Pointing them out isn't necessary. In my opinion, the article should focus more on the biochemistry and clinical pharmacology of sulbutiamine--information that can't be obtained simply by looking at the structure. Firewall62 (talk) 20:09, 30 March 2009 (UTC)
thread_title: Sulbutiamine structure

message: Over the past week, I have made numerous content additions and improvements to the article. At this point, practically every published source on sulbutiamine has been incorporated into the article and cited. Compared to other drugs, there is not a lot of information on sulbutiamine, and the length of the article will invariably be limited by the number of reliable sources. However, I believe that the article is currently B quality on the assessment scale, and I would like to see it reach GA quality in the future. Firewall62 (talk) 19:39, 6 April 2009 (UTC)
thread_title: Article development and assessment change

message: The abstract used for source 5 doesn't seem to really support the wording used in the adverse events portion about the bipolar person.  It doesn't seem to mention anything about a prescription being written, and, in fact, speaks of the dangers of over the counter medications.  This section of the article seems to imply more of a medical distinction on sulbatiamine than is warranted by the source cited.  Maybe this is in the full-text, but I doubt it based upon how the abstract is worded (i.e. "his psychiatric care was severely compromised through him defaulting appointments and frequent changes of psychiatrists")
71.2.123.68 (talk) 19:22, 25 August 2009 (UTC)
thread_title: Adverse effects 

message: Is a reference available for the erectile dysfunction and memory claim? Or is it included in the bi-polar article of reference 5? Access to the full article requires a paid subscription. From the abstract it doesn't sound like it would cover erectile dysfunction or memory aspects of Sulbutiamine.  —Preceding unsigned comment added by 184.77.198.218 (talk) 18:17, 15 June 2010 (UTC)
thread_title: Erectile and memory claim 

message: This will require some heavy citation but I feel the mechanism section does not address the fundamental issue of how sulbutiamine is transformed into thiamine. It should be added that the disulfide bond is cleaved in vitro, likely after entering the CNS where the thiol monomers are deprotonated to the thiolate anions leading to an intramolecular attack on the amide carbonyl, which is followed by ring closure and dehydration to the thiazolium cation. Or something like that.Glucuronide (talk) 05:59, 20 March 2015 (UTC)
thread_title: Mechanism

message: The following makes definitive statements in the content about how this drug that people take, works in people.  It is invalid to make blanket statements like this for CNS drugs (cancer is one thing, where we can pull a tumor out of somebody and get a decent idea of what it is doing to human tissue. can't do that with a human brain).  This needs to be way, way toned down and it made clear this is rodent work. 
;Mechanism of action
Sulbutiamine is a lipophilic molecule that crosses the blood–brain barrier more easily than thiamine. Its metabolism in the brain leads to an increase in the levels of thiamine and thiamine phosphate esters. While the exact mechanism of action of sulbutiamine is unknown, it is thought to occur through the upregulation of the reticular activating system, which is the center of arousal and motivation in the brain. The administration of sulbutiamine potentiates glutamatergic activity in the prefrontal cortex through a reduction in the density of kainate glutamate receptors, which may occur in response to a modulation of intrasynaptic glutamate. The facilitation of central glutamatergic transmission is a likely explanation for the ability of sulbutiamine to improve memory. In addition to its action on cholinergic and glutamatergic transmission, the administration of sulbutiamine reduces the release of dopamine in the prefrontal cortex, which increases the density of D1 dopamine receptors through a compensatory mechanism. The modulation of dopaminergic transmission may also contribute to the ability of sulbutiamine to improve memory. A possible explanation for the pharmacodynamics of sulbutiamine is the increased availability of thiamine triphosphate (ThTP). Although the full physiological role of ThTP is unknown, it is an integral component of synaptosomal membranes, participates in the phosphorylation of proteins, and activates chloride channels that have a large unit conductance. The activation of chloride channels by ThTP may be involved in the modulation of receptor binding.
- Jytdog (talk) 10:30, 24 April 2016 (UTC)
thread_title:  Problems with universal statements based on animal studies 

message: This whole page is a commercial for sulbutiamine. Having taken sulbutiamine a while, and gotten really sick from it, as did other people on amazon reviews I can say it does not have thiamine activity. It is chemically similar to thiamine disulfide which is a known thiamine transporter inhibitor in several studies. So it induces thiamine deficiency in the user. How about a section about this. Canyouguessmyname (talk) 23:23, 23 January 2018 (UTC)
thread_title:  scam 

message: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192637/pdf/jphysiol00562-0096.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC235561/pdf/jbacter00304-0307.pdf
I will change the page accordingly to something like "Sulbutiamine is a thiamine transporter inhibitor that is marketed as a nootropic" Canyouguessmyname (talk) 01:08, 27 January 2018 (UTC)
replies: text: These refs are not OK. Please do read WP:MEDRS.  There is link to recent reviews in pubmed in one of the beige boxes at the top of this page. Jytdog (talk) 02:59, 27 January 2018 (UTC)
thread_title:  sulbutiamin is a thiamine transporter inhibitor