Talk:Peptic ulcer disease

message: Can we get some accessible, plain language on this page for the layperson please? I'm interested in learning about stomach ulcers but am overwhelmed by all the specific medical terminology.  — Preceding unsigned comment added by 203.41.217.162 (talk) 00:55, 5 December 2011 (UTC)
thread_title: Plain English

message: In the section regarding stress and the pathophyHIHIHIHsiology of ulcers, there is a sentence asserting that H. pylori thrive in an acidic environment. This is contrary to other reliable sources in the article on H. pylori itself, and in fact the citation for this claim does not seem to substantiate it (I only have access to the abstract).
In describing the development of gastric ulcer in patients with high levels of gastric acidity, the H. pylori article indicates that the bacteria colonize the pylorus because it is more alkaline than the corpus of the stomach. The citation for this is even more clear; under Gastric Helicobacter species:
[quote]Urease is thought to allow short-term survival in the highly acidic gastric lumen, whereas motility is thought to allow rapid movement toward the more neutral pH of the gastric mucosa; this may explain why both factors are prerequisites for colonization of the gastric mucosa (450, 550, 551). Upon entry, gastric Helicobacter species display urea- and bicarbonate-mediated chemotactic motility toward the mucus layer (710). The spiral morphology and flagellar motility then assist in penetration into the viscous mucus layer, where the more pH-neutral conditions allow growth of the gastric Helicobacter species.[/quote]
I have not edited the article itself because I don't know how to do so without disrupting the entire section. If somebody experienced in editing could address what appears to be a patent error in this article, I would greatly appreciate it.
16:54, 27 July 2011 (UTC)
thread_title: H. pylori pH

message: Anti-acid treatments such as Zanitidine...
: Shouldn't this be Ranitidine instead? (Fhimpe 15:30 2 Jun 2003 (UTC))
:: Maybe it should also be noted that doctors will not always choose antacids as this reduces the amount of acid in the stomach which reduces the stomach's ability to protect itself and the body from bacteria, viruses, parasites etc. Many complications can arise from a lack of the protective acidic environment in the stomach including pneumonia, parasitic infections, H. Pylori2 infections etc.   —Preceding unsigned comment added by 61.68.50.65 (talk) 13:56, 18 July 2008 (UTC)
replies: text: Also Ranitidine, although I suppose "anti-acid" should not be confused for an antacid - ranitidine is an H2 receptor antagonist. PGRandom (talk) 23:08, 24 February 2014 (UTC)

text: You're right, I forgot to stick that in (I'll do it later if I've got a chance). There's probably exceedingly little point in measuring anti-HP IgM in a chronic infection! TMN (to my knowledge) it's still controversial to treat HP "blind" without biopsy, but I've seen it happen.  JFW | T@lk 07:55, 29 Apr 2004 (UTC)

text: Wouldn't the levels of antibody be an idicator whether there is a current infection? Kadhumia flo (talk) 21:39, 1 June 2010 (UTC)
thread_title: Anti-acid

message: Old intro said:
:By far most instances are now known to be due to Helicobacter pylori, a spiral-shaped bacterium that lives in the acid environment of the stomach.
This wording was not really true, as the linked article states, ~70% of H. pylori infections are asymptomatic, and ~2/3 of world population is infected.  So while H. pylori is only one causative factor, in most case requiring some other factors (whether genetic or environmental) to trigger ulceration. NTK 23:27, 30 January 2006 (UTC)
thread_title:  edit 

message: I have heard the issue described in black and white terms:
*Ulcers are caused by stress alone, i.e., no physical cause whatsoever
*Ulcers are caused by Helicobacter pylori, i.e., stress is not a factor in the slightest
Isn't it somewhere in the middle of these extremes? --Wing Nut 19:01, 5 July 2006 (UTC)
thread_title:  Stress and ulcers 

message: It is possible for a CLO test to be negative yet to have positive urease breath test results. It seems helicobacter can colonise the duodenum and be the cause for so-called "idiopathic" duodenal ulcers:  JFW | T@lk 08:58, 6 January 2008 (UTC)
thread_title:  H Pylori in the duodenum 

message: What can be done to subside the ulcer naturally?  —Preceding unsigned comment added by Mary Jewel (talk • contribs) 16:25, 2 February 2008 (UTC)
thread_title:  Preventative Treatment 

message: I removed a paragraph in the 'Stress and Ulcers' section that was copied directly from the source it cited. One reason it raised suspicion was that it included POV statements ("this is dichotomised thinking") and didn't flow well with the rest of the section, repeating some info from the paragraph above. Here is the reference in case anyone wants to rework any info that may be relevant to include in this section: http://www.bmj.com/cgi/content/full/316/7130/538 202.3.37.235 Orangeblossomspecial (talk) 11:12, 22 September 2008 (UTC)
thread_title:  Plagiarism 

message: Isn't the presence of ulcers a possible indication that a patient suffers from these diseases?  —Preceding unsigned comment added by 67.182.219.132 (talk) 18:16, 26 November 2008 (UTC)
thread_title:  Chron's disease, Ulcerative Colitis 

message: This business about an ulcer needing to be "equal to or greater than 0.5 cm" is not widely accepted or useful. Ulcers and erosions are mucosal defects; the difference betwee the two is that an ulcer involves the "full thickness" of the mucosa (ie. right down to the base of muscularis propria) and an erosion involves partial thickness (it not as far as the muscularis propria) Erosions TEND TO be smaller than ulcers but it is not helpful or pathologically correct to use a size criterion. 
Isn't the presence of ulcers a possible indication that a patient suffers from these diseases?  —Preceding unsigned comment added by 67.182.219.132 (talk) 18:16, 26 November 2008 (UTC)
thread_title:  Definition of an ulcer 

message: The Epidemiology Section infographic is very unclear. No units are specified. I have no idea what it means.--Jp07 (talk) 20:23, 1 August 2011 (UTC)
thread_title:  Epidemiology infographic 

message: I'm sure that picture of a "Deep gastric ulcer" is wonderfully illustrative to someone with the appropriate background, but it doesn't help me at all.  How about a side by side, showing normal tissue versus ulcerated tissue?  'Cause I don't see anything wrong in that picture, and neither do most readers. 98.82.84.209 (talk) 19:01, 29 May 2012 (UTC)
replies: text: I second your view.  Brendon is here 06:01, 5 June 2012 (UTC)
thread_title:  Picture 

message: The current treatment section seems to underplay the importance of surgical interventions in treatment of peptic ulcers. For example it makes the unsourced and, I believe, false claim that the introduction of PPI's has rendered surgical treatment by vagotomy "obsolete". Here is a medical textbook source  
To quote that source:
"What operations are used to treat duodenal ulcers?
* Truncal vagotomy and pyloroplasty (V and P) or gastrojejunostomy
* Truncal vagotomy and antrectomy with Billroth I or II anastomosis
* Subtotal gastrectomy with Billroth I or II anastomosis
* Selective vagotomy (just the vagal branches to the parietal cells in the stomach)
* Total gastrectomy"
===Reference===
PGRandom (talk) 23:01, 24 February 2014 (UTC)
thread_title:  Surgical treatment 

message: PGRandom (talk) 23:01, 24 February 2014 (UTC)
thread_title: Reference

message: ... in high-risk ulcers may be equivalent. doi:10.1001/jamainternmed.2014.4056 JFW | T@lk 11:40, 7 November 2014 (UTC)
thread_title:  PPI infusion vs boluses 

message: In the leader, it states that,
::"Diet does not play an important role in either causing or preventing ulcers."
while in the body it says,
::"Studies in the varying occurrence of ulcers in third world countries despite high H. pylori colonization rates suggest dietary factors play a role in the pathogenesis of the disease."
Somebody more knowledgeable than me should take a look at this. -Xanthis (talk) 21:14, 22 March 2015 (UTC)
replies: text: Trimmed the poorly sourced one. Doc James (talk · contribs · email) 02:30, 23 March 2015 (UTC)
thread_title:  Diet: contradiction in article 

message: Hello fellow Wikipedians,
I have just added archive links to  on Peptic ulcer. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20110618102000/http://www3.interscience.wiley.com:80/journal/120151138/abstract?CRETRY=1&SRETRY=0 to http://www3.interscience.wiley.com/journal/120151138/abstract?CRETRY=1&SRETRY=0
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
Cheers. —cyberbot IITalk to my owner:Online 18:36, 28 August 2015 (UTC)
thread_title:  External links modified 

message: Wikipedia says:
"Transmission is by food, contaminated groundwater, and through human saliva (such as from kissing or sharing food utensils)".
I did not find the word "kiss" or "kissing" in the reference.
How risky is it to kiss someone who has H.pylori? H.Pylori may require antibiotics, so it is better to avoid it!
Any other tips to avoid h.pylori?
ee1518 (talk) 12:30, 25 September 2015 (UTC)
thread_title:  Avoiding kissing and other means to avoid H.pylori in Western World (Western Europe) 

message: doi:10.1016/S0140-6736(16)32404-7 JFW | T@lk 20:07, 6 August 2017 (UTC)
thread_title:  Lancet 

message: " An ulcer in the stomach is called a gastric ulcer, while that in the first part of the intestines is a duodenal ulcer."
"Termed" is not needed. Doc James (talk · contribs · email) 04:49, 27 February 2019 (UTC)
thread_title: Wording

message: The use of C14-labelled urea is outdated. The tracer now used is the much cheaper and non-hazardous C13-labelled urea. C13 can be measured on a bench top instrument "While you wait." It is probably also worth mentioning that the breath test  has a somewhat better performance than the stool antigen test - on the basis of percentage false positives and false negatives, as well as ease of administration. 2407:7000:8222:6100:8434:9C60:1F25:99F9 (talk) 07:13, 2 July 2022 (UTC)
thread_title:  Diagnostic breath test 

message: https://pubmed.ncbi.nlm.nih.gov/8189011/
Japan: 105,000 USA: 103,000
Per year. I only read the first line, and the death rate Wikipedia quotes: 3,000 
Another source (I think government) said 1,000 new cases per year. 
I'm not going to edit anything because I know peptic ulcers aren't usually fatal, but I want to edit the simple.wikipedia article. So the death rates in the USA are good to use (I don't think UK/Scot NHS website covers deaths). China will probably hide their statistics and could be different to the US/UK
Maybe I'll find a reference for https://simple.m.wikipedia.org/wiki/Peptic_ulcer but not change the en.wikipedia article. Hopefully that isn't a mistake  W;ChangingUsername (talk) 13:09, 22 May 2024 (UTC)
thread_title:  Deaths