lflage/wiki-talks huggingface dataset:
Talk:Tigecycline

message: I would suggest to expand on the issue of mortality, such as increased of mortality was due to what? Without such specification it's unclear and vague.
About black box, I would suggest to add what the black box actually says. Dmatteng (talk) 15:59, 31 March 2015 (UTC)
replies: text: Its an unusual drug as almost nothing is resistant to it in vitro, but higher mortality is seen specifically in the case os severe infections, suggesting some non-resistance related issue with clinical efficacy. There are some details in the US pkg insert.Formerly 98 talk|contribs|COI statement  16:55, 31 March 2015 (UTC)
replies: text: brilacidin Might be even more promising, would nice if editors would improve that article. Regarding the mortality of this drug: Is the mortality rate due to side-effects? Or due to overgrowth of non-susceptible bacteria? Or due to it's inability effectively treat the susceptible bacteria? Dmatteng (talk) 05:24, 1 April 2015 (UTC)
thread_title:  Mortality and black box by USFDA 

message: We felt that the group did a good job keeping a neutral point of view and using reliable sources. Some of our suggestions are to include the drug class in the lead section. We also felt that abbreviations such as cSSTI and cIAI may not be necessary if they're fully written out. For the susceptibility section, we wonder if this data is meaningful for the general population, especially since susceptibilities can vary from location to location. For the dosing section, it may be helpful to combine the information with the kidney and liver problems to make the section look a little more clean. Finally for the DDI section, it may be useful to give a basic explanation of the mechanism behind the interactions. There is also a sentence at the bottom of the section that seems out of place. 
LDP02 (talk) 18:08, 9 November 2015 (UTC)
thread_title:  Peer review for 3 icecreamcones' edits 

message: I have marked for missing citations obviously incorrect names containing amino(hydroxy)methylidene or even "amino-hydroxy-methylidene" groups not present in the structure (however not totally wrong, these would be presumed minor tautomeric forms), wondering if these names came from some authoritative sources. INN definition publication has correct "carboxamide" in name, however this name is also not absolutely correct – has three adjacent opening square brackets. —Mykhal (talk) 17:59, 13 September 2017 (UTC)
replies: text: Pubchem illustrates this chemical as an alternate tautomer, and the name in our infobox generally agrees with that form. Drugbank and Chemspider have the tautomer illustrated in our article and names that look correct for it. DMacks (talk) 12:54, 14 September 2017 (UTC)
thread_title:  Wrong IUPAC names
Talk:Space Lords

message: I did my best to describe the game accurately.  It's a shame that there is no documentation on the game out there that gives the amount of detail I shot for.  One thing, though.  I cannot, for the life of me, remember the name of one of the races.  They look just like the Troids, but are blue instead of orange and are tougher, too.  As I recall, they appear 6th, between the Raptors and the Krystar.  Granted, it's been about 15-20 years since I played Space Lords.
Oh, and I *will* own this game some day.  Oh yes.  It will be mine.  :-)
Deejaye6 (talk) 03:14, 22 October 2008 (UTC)
replies: text: very nice, however;  :-) LOL! Just kidding! --Steve, Sm8900 (talk) 16:26, 12 February 2010 (UTC)
replies: text: Ohhh, if only I could have had a friend videotape it back then!  :-)  A friend who was active on the Atari BBS back then posted a maneuver I invented and he named it after me.  I would fly just fast enough to stay out of the enemy guns' range, but slow enough that they would continue to pursue.  I would turn this way and that to get them to collect together in a small cloud of bad guys.  Then I would slam the ship into reverse (holding the rear-view button to see where I was going) and hit the Cloak and Hyperspace buttons to get the invisible boost.  As I passed through the cloud, I'd release the rear-view button (now watching them in front of me as I continue backwards) and nuke them, point-blank!  With the speed boost, I'd still be going back fast enough to avoid the blast, and the bad guys with Hyperspace could not react in time to avoid it.  OutRAGEous!!  :-D Deejaye6 (talk) 21:15, 18 October 2013 (UTC)
thread_title: Inaccuracies Fixed

message: About three weeks ago or so, I added a table listing all eight alien races in Space Lords with the specific attributes associated with each. They are in order: Troid, Hydrus, Raptor, Octon, Noptera (my personal favorite since they were so difficult to hunt down), Naqar, Krystar, and Xyclops. I received a message thanking me for adding the table and to answer your question, no I do not own a Space Lords console. I simply remembered the characteristics from memory since I played it so often while at university.
Lomnoir (talk) 06:04, 19 January 2009 (UTC)
thread_title: All Alien Races Added (with Attributes)
Talk:Hydralazine

message: I dunno...for some reason using an exam review book as source seems strange, maybe because it's a secondary/tertiary source already and it's leaves out so many things.  -- Bubbachuck (talk) 00:59, 31 March 2009 (UTC)
thread_title:  First Aid for Step 1 used as a source 

message: Apart from the web site it's linked to which does not give any source itself, I could not find any evidence in the literature that hydralazine is an NO donor. The closest I found for a mechanism is this paper: Knowles HJ, Tian YM, Mole DR, Harris AL (2004) Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ. Res. 95(2):162-9. However, this paper proclaims a mechanism altering protein expression which would not explain if it can cause relaxation of blood vessels in an organ bath (not that I ever investigated, might be an interesting student experiment!). -- 134.225.154.77 (talk) 14:44, 27 April 2009 (UTC)
thread_title:  Hydralazine as an NO donor 

message: --75.142.159.240 (talk) 15:35, 6 June 2010 (UTC)
thread_title:  Hydralazine and it's effect of limiting B6 in the human body would seem to be an important subject that is not addressed.   

message: What does hydralzine look like? What is stamped on the pill? 209.169.222.202 (talk) 02:51, 6 May 2024 (UTC)
thread_title:  Picture
Talk:Domiziana Giordano

message: She is a very notable actress. The fact that she apparently has edited the page herself doesn't mean that the page has to be deleted. Well, just google. Colchicum 18:13, 18 July 2007 (UTC)
replies: text: At least five articles point here, she participated in a number of very notable films (Nostalghia etc.), and she has received at least one award at an international film festival.Colchicum 18:29, 18 July 2007 (UTC)
replies: text: Sorry about the tag - should have looked more carefully. Sander Säde 19:09, 18 July 2007 (UTC)
thread_title: Untitled
Talk:Tobramycin

message: i wanted to know these are the drops used for ear infections when there are tubes installed?  —Preceding unsigned comment added by 69.145.204.11 (talk) 05:35, 8 March 2008 (UTC)

message: Can we put this in 8 day old bby eyes 2600:387:F:812:0:0:0:9 (talk) 17:28, 30 December 2021 (UTC)
thread_title:  ?
Talk:Black Storks (Mujahideen)

message: This article seems to exclusively site unreliable sources. The 9th Company is a highly fictionalised film based loosely on events of the Soviet-Afghan War and the Russian-Chechen War, it is not a historical document and cannot be treated as such. As for the claim that an entire 3000-strong Brigade was annihiliated in one battle in Afghanistan, I doubt that very much, since the Soviets only took 14,500 combatant fatalities during the entire course of the war.  —Preceding unsigned comment added by 81.129.179.119 (talk) 18:55, 14 February 2008 (UTC)
thread_title:  Poor Quality
Talk:Pyrazinamide

message: Under Medical Uses, it states that "Pyrazinamide in conjunction with rifampin is a preferred treatment for latent tuberculosis.[3]" Yet since 2004, the regimen is now widely avoided after being associated with severe and fatal cases of hepatotoxicity. This needs to be updated. 129.78.32.21 (talk) 03:14, 10 February 2013 (UTC)
thread_title:  Pyrazinamide + Rifampicin is NOT recommended
Talk:Spiny-cheeked honeyeater

message: Hello! This is to let editors know that :File:Spiny-cheeked Honeyeater 3434 - Patchewollock Conservation Reserve.jpg, a featured picture used in this article, has been selected as the English Wikipedia's picture of the day (POTD) for September 12, 2022. A preview of the POTD is displayed below and can be edited at Template:POTD/2022-09-12. For the greater benefit of readers, any potential improvements or maintenance that could benefit the quality of this article should be done before its scheduled appearance on the Main Page.  If you have any concerns, please place a message at Wikipedia talk:Picture of the day. Thank you! Adam Cuerden (talk)Has about 7.9% of all FPs 16:43, 31 May 2022 (UTC)
thread_title:  Featured picture scheduled for POTD
Talk:Risedronic acid

message: Risedronate Sodium is also manufactured by Cipla Ltd. in India. I know this because I bought some from a Canadian pharmacia and received tablets in packaging that identified them as the manufacturer.
Does that count as "original research", which isn't permitted?
SConnecticut (talk) 16:02, 10 March 2008 (UTC)
thread_title:  India 

message: Optinate, is available from Sanofi Aventis as 35mg risedronato sodico (Risedronic Acid)- information from package leaflet no0472G161. Also availabe on line are tablets called OptiNate which are a vitamin supplement for pre/post natal women.  — Preceding unsigned comment added by 178.22.249.230 (talk) 08:18, 31 December 2011 (UTC)
thread_title:  Alternative name 
Talk:Nialamide

message: The article currently says "Nialamide is sold under Psicodisten, Niaquitil, Nialamid, Niamidal, Niamide, Novazid, Nuredal, Niamid (Italy, Belgium, Netherlands, England, United States),[13] Niazin, Nyazin, Surgex (Italy),[1] Mygal, Delmoneurina, Isalizina (Italy),[1] Espril (Italy),[1] and Nyezin.[14]" However, according to the Martindale reference book, nialamide is no longer on the market in any country... DiamonDie (talk) 11:15, 9 February 2009 (UTC)
replies: text: According to drugs.com, Nialamide is available as Niamid in Luxemburg. I will try to contact a pharmacist in Luxemburg to really verify this, but I guess that won't be a "legitimate" source. Is the mention on drugs.com a legitimate source? Also, where should I put the info that it's still sold in Luxemburg? C.d.rose (talk) 20:44, 18 July 2011 (UTC)
thread_title:  Availability? 

message: The WikiProject classification for Nialamide is Start-class. However, the page has less than 100 words, so it might not meet the grading criteria.   ~ Tom.Reding (talk ⋅dgaf)  20:41, 10 July 2016 (UTC)
thread_title:  Please confirm classification
Talk:Disabled (poem)

message: As with the other poem articles recently created on Owen poems, this article should not contain the text of the poem if it is available on wikisource. Mrathel (talk) 04:33, 18 December 2009 (UTC)
replies: text: This is probably the stupidest "rule" on WP! I'd like to see some proof that such a policy exists. Roger (talk) 08:51, 31 October 2010 (UTC)
thread_title: Poem Text

message: I want to loading this site. Bangabdul69 (talk) 14:24, 10 July 2015 (UTC)
thread_title:  Suggested correction
Talk:Sevelamer

message: http://cjasn.asnjournals.org/content/7/6/934/F1.large.jpg
...
http://cjasn.asnjournals.org/content/7/6/934.full
Could it benefit also prediabetic people who have a normal kidney function? Optimal HbA1c is < 5%.
88.192.242.201 (talk) 14:12, 10 June 2016 (UTC)
replies: text: The authors only speculate within the confines of diabetics with CKD. Biochemistry&Love (talk) 18:28, 12 December 2016 (UTC)
thread_title:  Benefits HbA1c 

message: The brand "Renavel" is not a relevant brand of sevelamer for the English Wikipedia. Frankly, I doubt that any medication brand produced by "Allianze Med Pharma," a Pakistani company, is of relevance to readers in the US/UK. Please see the manual of style for Wikipedia:WikiProject Pharmacology. Biochemistry&Love (talk) 05:27, 28 December 2016 (UTC)
thread_title:  Foreign Brands
Talk:Argatroban

message: I suggest that you reference use for the Thrombosis with Thrombocytopenia Syndrome (TTS) following COVID-19 Vaccination. Mdjkf (talk) 03:51, 8 June 2021 (UTC)
thread_title:  Suggested edit relating to TTS
Talk:Dactinomycin

message: Structure lacks stereochemistry. I believe the structure is here: http://www.chemspider.com/Chemical-Structure.10482167.html --ChemSpiderMan (talk) 17:34, 27 July 2008 (UTC)
replies: text: I have now added a structure with stereochemistry.  -- Ed (Edgar181) 18:19, 23 October 2008 (UTC)
replies: text: Can we have a brief description of the structure ? eg is it two macrolide rings linked with ?? - Rod57 (talk) 02:32, 24 March 2013 (UTC)
thread_title: Structure

message: We may allow a link to a page that adds or verifies information, but should we suffer such arrogant misuse of Wikipedia as the current BioAustralis add here? they give a link not to an useful monograph of theirs, but to their order form ! Lushi (talk) 22:47, 28 September 2008 (UTC)
thread_title: Rude advertisment?

message: --Jsjsjs1111 (talk) 09:52, 14 May 2012 (UTC)
thread_title:  unused image
Talk:Ethambutol

message: Do we have any sources on the mechanism of action? They seem wanting.
(As a note, drugs.com is nonspecific when describing the mechanism of ethambutol's action).
--Spiffulent (talk) 17:30, 21 May 2010 (UTC)
thread_title:  MoA 

message: To this reader who is a least well versed in Chemistry, it would appear that this article is sufficiently sourced. If we still need a source for the mechanism of action, might I suggest this one  Balonlon (talk) 08:17, 27 June 2023 (UTC)
replies: text: Seeing no objections and no new edits since this prior assessment, removing the maintenance template on the article based on silent consensus (See #8).  Balonlon (talk) 09:43, 28 November 2023 (UTC)
thread_title:  RE: additional citations for verification
Talk:Dacarbazine

message: Decarbazine was developed by Y. Fulmer Shealy, Phd at Southern Research Institute in Birmingham, Alabama. Development was funded with federal grant monies. Source: Nancy Shealy - Daughter of Developer 
--Ngshealy (talk) 20:34, 26 February 2013 (UTC)
thread_title:  Decarbazine Developer 

message: Some information on efficacy would be good. Response rate, progression free survival and overall survival. Danensis (talk) 11:14, 11 February 2014 (UTC)
thread_title:  Efficacy 
Talk:Phentolamine

message: Hi, sorry if this discussion is in the wrong place, but it is my first time contributing to Wikipedia (hopefully more will come).
I found the wikipedia entry for the google search result for Phentolamine terrible:
Phentolamine - Wikipedia, the free encyclopedia 
en.wikipedia.org/wiki/Phentolamine‎
Phentolamine has recently been introduced in the dental field as a local anesthetic reversal agent. Distributed by Septodont, OraVerse is a Phentolamine ...
I think the entry should mention only a general description (like Phentolamine is a reversible non-selective alpha-adrenergic antagonist.) and without any commercial names. Having commercial names in the google search entry makes it sound like a biased article funded by the company which is advertising. In this case it is specially serious as this is not even the primary use of the drug.
Igorbraz (talk) 11:38, 27 February 2014 (UTC)
thread_title:  Google search results 

message: I see a lot of advertisements for trimix gel. Is this a thing? (See Talk:Trimix (injection)]]. 76.194.214.123 (talk) 09:00, 30 June 2014 (UTC)
thread_title:  Trimix gel?
Talk:Happy Humphrey

message: I am in the process of improving this article with good references, please do not prod or delete it. The Parsnip! 20:26, 18 July 2007 (UTC)
thread_title:  Please do not prod or delete 
Talk:Imipenem

message: Since when is imipenem called Gorill-icillin? We use it everyday and I have never heard of that.  —Preceding unsigned comment added by Maejmk20 (talk • contribs) 17:28, 8 February 2008 (UTC)
replies: text: Sounds like a joke. In my hospital we called it Domestos for its wide antimicrobial spectrum. JFW | T@lk 21:17, 17 February 2008 (UTC)

message: http://jac.oxfordjournals.org/cgi/content/full/58/5/916 - 20 years of imipenem. JFW | T@lk 21:17, 17 February 2008 (UTC)
thread_title: Review
Talk:Antonio Bass

message: Is his name really Antonio Bass or Chad Steven Henne? Please look up in Wikipedia:Naming conventions (people) to determine which one is appropriate.--Janarius 18:28, 18 July 2007 (UTC)
replies: text: I don't know anything about him except what's in or linked from this article, but I reckon the reference to Chad Henne is just a mistake; I notice that the linked ESPN profile for Henne says he's two years older than Bass and born in Pennsylvania. --Paul A 01:40, 15 August 2007 (UTC)

text: Also, I see that there's a separate article for Chad Henne that supports my conclusion. --Paul A 01:44, 15 August 2007 (UTC)
thread_title: His name
Talk:MiPT

message: The previous name of this article (Methylisopropyltryptamine) does not follow most of Wikipedia's top five criteria for article titles:
Recognizability: Methylisopropyltryptamine is not recognizable to those who are not an expert in chemistry or pharmacology. MiPT is what someone would recognize if they arrived at this article from, say, the DiPT article.
Naturalness: aside from MiPT, readers would be mostly likely to search for N-methyl-N-isopropyltryptamine, not Methylisopropyltryptamine).
Consistency: other related articles such as DiPT, DALT and MALT as well as drugs such as MPT, DPT, etc. all use the [Acronym] (psychedelic) format.
In addition, Methylisopropyltryptamine does not follow the WP:COMMONNAME guidelines. 
I will be going through the Cleaning up after a move checklist in the coming days. Thanks! Repylom (talk) 22:05, 28 November 2023 (UTC)
thread_title:  Title change
Talk:Entacapone

message: Does it cross the blood-brain barrier like tolcapone? cyclosarin 04:11, 21 August 2007 (UTC)
thread_title:  Blood-brain barrier 

message: Is the manufacturer only using capitalization "Comtan" now (as on its website), or does the packaging still use "COMTan"?  If the packaging does not still use "COMTan", can we get a current logo?  I have ensured that there are redirects for both, to ease navigation.  Thanks!    — Jeff G. ツ 17:41, 20 March 2010 (UTC)
thread_title:  "Comtan" or "COMTan" capitalization 

message: and some sources for the current content. - Rod57 (talk) 14:52, 16 August 2011 (UTC)
thread_title:  Can we have results from clinical trials 

message: Originally, the article before this course assignment was broken down only by 1) lead section, 2) 'side effects', 3) 'products', and finally  4) 'references'. Thus, we felt there was potential to add significant value to this article, particularly for patients and students learning more about the drug.
Our main goal was to phrase the lead section so entacapone would be easy to understand with simple concepts. We placed tremendous emphasis on using lay language and hyperlinked phrases that were needed for context to understand more about entacapone, levodopa/carbidopa, and the treatment of Parkinson's disease. We reserved more technical information for newly created sections.
These newly created sections included headings 1) 'medical use', 2) 'adverse effects' (renamed from side effects), 3) 'mechanism of action', 4) 'pharmacokinetics', and finally 5) special populations. 
This covers: 
* what entacapone is being used for
* what are its side effects 
* how the drug works in the body 
* what the body does to the drug 
* if special populations such as children/pregnant mothers can use this medication 
We believe these headings to be the most pertinent for the audience of this article.
From the original article, we removed the phrase 'Entacapone is a member of the class of drugs known as nitrocatechols'. This sentence had no supporting reference nor wikipedia page for nitrocatechols. 
Finally, we edited the right-side panel of Clinical/Pharmacokinetic data with spell check (in addition to the complete article) and verified the numerical values listed for accuracy per entacapone package insert (last revision 2014, Novartis). 
Future edits will expand on topics listed here in the Talk section, mechanism of action (picture would be nice), and supporting clinical trials for efficacy in Parkinson's disease.
Ttrannn 11 (talk) 13:30, 5 November 2015 (UTC)
thread_title:  Wiki Education Foundation Course Assignment - Rough Draft 1
Talk:Iloprost

message: when was this drug first formulated and found to be effective? FleetingJoy (talk) 03:46, 10 March 2010 (UTC)

message: Will add some information on IV Iloprost and its use such as for Raynaud's phenomenon.  86.155.184.123 (talk) 00:07, 15 March 2008 (UTC)
thread_title:  IV formulation 

message: The quoted CAS number is wrong. it is 78919-13-8  —Preceding unsigned comment added by 192.36.117.138 (talk) 08:13, 8 July 2008 (UTC)
replies: text: Actually, both resolve to iloprost in eMolecules. I've added 78919-13-8 to the article. Thanks, Fvasconcellos (t·c) 12:34, 8 July 2008 (UTC)
thread_title:  CAS number 

message: Does "The approved dosing regimen ... is 6 to 9 times daily (no more than every 2 hours) during waking hours" mean the interval is to be (2 hours or less) or than that no more doses are to be given within 2 hours ie interval is (2 hours or more)?--SilasW (talk) 08:36, 13 November 2008 (UTC)
thread_title:  Frequency of dosage 
Talk:Methylergometrine

message: Why does Norforms (OTC vaginal deodorant suppository product) redirect here? Ummel (talk) 02:14, 14 July 2011 (UTC)
replies: text: http://www.drugbank.ca/drugs/DB00353 strangely claims that Norform contains methylergometrine. I've changed the redirect to Benzethonium chloride, which seems to be the true active ingredient (). Thanks for pointing this out! --ἀνυπόδητος (talk) 07:03, 14 July 2011 (UTC)

text: While I was looking around I saw that a few sites had listed it as a brand/formulation of methylergonovine, but most of them pointed back to the drugbank.ca link. Micromedex/Martindale's seems to only list the vaginal deodorant (Benzethonium chloride), and not methylergonovine maleate. It must be some sort of error on drugbank.ca's part, unless it is an old or foreign brand name/formulation. Thanks for the quick action! Ummel (talk) 02:35, 22 July 2011 (UTC)
thread_title: Norforms redirect
Talk:Californication

message: Californication is a portmanteau I first saw on bumper stickers in Colorado, to wit "Don't Californicate Colorado."  I don't recall the exact date they appeared, but it was sometime prior to a statewide referendum for support of the 1976 Winter Olympics.  That vote occurred on Nov. 7, 1972, when the voters rejected a 5 million dollar bond issue to fund the Games.
I vividly recall the bumper stickers (and some window placards) because of the titillating aspect of the word, and as an impressionable early teen, it is emblazoned in my memory.  It also introduced me to politics, because the crusader against the games, Dick Lamm, eventually became governor of the state.
More details can be found at http://www.denver-rmn.com/millennium/1012stone.shtml
Schleprock 21:51, 9 August 2007 (UTC)
thread_title: Wiktionary