Talk:Antigen

message: Dudes.  How about writing this over in English?--149.152.34.80 (talk) 21:55, 17 May 2009 (UTC)
thread_title:  YO! Way To techy 

message: 1st para is incomprehensible to those who don't already know what an antigen is. And then what would be the point of the Wikipedia? Showing off? --189.130.3.218 (talk) 04:28, 26 July 2015 (UTC)
thread_title:  Too technical 

message: This paragraph doesn't match what I'm reading in other articles.
Is this paragraph implying that polyclonal antibodies cannot attack free floating antigens?
:I think you'd be dead very soon and very quick if you only had monoclonal antibodies in your bloodstream. (By their nature monoclonal systems are an artificial construct for research/therapy - did that make sense?) Changing that right now, will come back and do a whole overhaul--ZZ 14:59, 1 Oct 2004 (UTC)
replies: text: Of course it should be. That's the point of the process. If you revise it in a way we don't like, it is always possible to change or revert it. Also remember to sign yourself using four tildes ~~~~ --Eleassar777 11:17, 14 May 2005 (UTC)
thread_title:  Should the header Freefloating Antibodies be Freefloating Antigens? 

message: Source: https://en.wikipedia.org/wiki/Antigen_processing#The_exogenous_pathway
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026165/
All antigens come from outside the body by the most basic definition (foreign substance). There are of course multiple definitions as other users point out here, but classifying exogenous antigens as foreign (outside the body) suggests endogenous antigens are self-antigens (inside the body), which is incorrect. Exogenous versus endogenous antigens refers to where the antigens are located relative to a cell, not the entire body. This has important implications on how antigens are processed and loaded up onto MHC, then displayed to Tc or Th lymphocytes. Endogenous antigens start from within the cytoplasm (infected cells or nucleotide-based vaccines) and are loaded onto MHCI, while exogenous antigens are those engulfed by Antigen Presenting Cells (such as macrophages or activated B cells), they never  enter the cytoplasm, and are loaded onto MHC II. At the very least, it should be mentioned there are multiple definitions of endogenous versus exogenous in the fields of biology, but in immunology there is a special and important set of definitions for these two words. This concept is very important for understanding whether Tc or Th cells are activated (which is a difference in life or death for the cell with an antigen). Laird.sheldahl (talk) 16:45, 10 June 2022 (UTC)
thread_title: definitions of Endogenous versus Exogenous antigens do not match definitions elsewhere on wikipedia (or the literature)

message: An antigen is ANY BODY that stimulates antibody prouction, from the immune system against it.
Source: http://www.nlm.nih.gov/medlineplus/ency/article/002224.htm  --Chazz88 22:08, 11 October 2005 (UTC)
thread_title: Antigen Correction of DEFINITION

message: In my immunology course I was given slightly different definitions for antigen and immunogen. According to what I learned, antigens are substances that can bind to components of the immune system, but not necessarily cause an actual immune response. An immunogen, however, was defined as a substance that can cause an acquired immune response. The definition for antigen given in this article is different. Any thoughts? -Campaigner444 00:46, 4 November 2005 (UTC)
replies: text: I agree, an immunogen is not the same thing as an antigen XApple (talk) 16:13, 7 June 2008 (UTC)

text: I agree as well. An immunogen is a type of antigen, but not all antigens are immunogens. As you have said, immunogens elicit a response from the immune system, but antigens do not always cause a reaction. There should be some differentiation.--Mcoj87 (talk) 19:10, 9 December 2008 (UTC)
thread_title:  Antigen vs. Immunogen 

message: It is widely recognized by medical professionals that menstrual fluid contains a bacteria associated with Daujeszky's Disease, a  antigen in men that has gone unrecognized for many years. Known side effects include stomach cramps, nausea, diarrhea, and severe inflammation of the urethra. If not treated properly it could result in urinary infection lasting for up to several days.
A finding of Dr. Joan Hiniesne, a professor at Cambridge University, suggests that Daujeszky’s Disease occurs primarily in young sexual active men. A case study in Austin, Texas followed a man, “Dave” (hiding actual name under privacy clause), for several months after having intercourse during the menstrual cycle of a female participant. The study concluded that symptoms often arise fairly suddenly and last for any number of days; perhaps even weeks depending on severity. “This is a very common effect of intercourse during the menstrual cycle” Reported by Casey Snyder of the Washington Medical Journal in an article entitled: Presumptions of Safety during Sex.
information by User:Kjsogjs (contributions) over four edits 7 February 2007
removal --ZayZayEM 01:19, 7 February 2007 (UTC)
thread_title:  Removed text 

message: that is the result of vandalism, right? 0.0 --TiagoTiago (talk) 10:14, 20 November 2007 (UTC)
replies: text: I hope it is ok, I reverted the poopy thing--TiagoTiago (talk) 10:24, 20 November 2007 (UTC)
thread_title:  "Origin of poopy", vandalization, right? 

message: The basic definition given on this page (i.e. antigen = immunogen) is wrong. There needs to be two separate articles. One is a sub-class of the other.
Immunogens refer to antigens that are able to stimulate a specific adaptive immune response when introduced into the body. Not all antigens are immunogens. To be immunogenic, antigens must fulfil certain criteria, such as i/ being large enough, ii/ chemically complex and iii/ in most of the cases foreign.
For instance a hapten is an antigenic substance but not immunogenic. XApple (talk) 17:24, 8 June 2008 (UTC)
thread_title:  This page contains false information 

message: This article should discuss the chemical composition of antigens. As well as their structure, capabilities...  —Preceding unsigned comment added by 76.106.58.112 (talk) 01:08, 14 May 2009 (UTC)
thread_title: Chemical Composition

message: Why is the article entitled "Antibody generator"? "Antigen" is far more commonly used in the UK. Also, the text of the article uses the term "antigen", not "antibody generator". Axl ¤ [Talk] 10:44, 29 August 2009 (UTC)
replies: text: Agree that "antibody generator" is not a widely used term (although it does make the "antigen" concept explicit). After reading the discussions and the article, I think the title should be "immunogen" and that "antigen" should be a subheading within the article. Immunology is complicated with several overlapping concepts, but to the best of my understanding this is the correct heirarchy Johnfravolda (talk) 14:27, 29 August 2009 (UTC)
replies: text: Agreed. The term simply isn't used, and probably wouldn't be recognized if it was. Similarly, we have a modem article, not a modulator-demodulator article. – ClockworkSoul 02:56, 30 August 2009 (UTC)
replies: text: I doubt that the term "antibody generator" has ever been used. It (and the reference) should be dropped.  —Preceding unsigned comment added by Rstenutz (talk • contribs) 14:27, 15 July 2010 (UTC)
thread_title:  Article title 

message: Here is the current lead paragraph of the article:
:An antigen (from antibody generator) originally defined as any molecule that binds specifically to an antibody, the term now also refers to any molecule or molecular fragment that can be bound by a major histocompatibility complex (MHC) and presented to a T-cell receptor. "Self" antigens are usually tolerated by the immune system; whereas "Non-self" antigens are identified as intruders and attacked by the immune system. Autoimmune disorders arise from the immune system reacting to its own antigens. 
And here is the definition from the MedlinePlus website of the National Institutes of Health:
:"An antigen is any substance that causes your immune system to produce antibodies against it. An antigen may be a foreign substance from the environment such as chemicals, bacteria, viruses, or pollen. An antigen may also be formed within the body, as with bacterial toxins or tissue cells."
Now which one do you think most readers would understand?
This page needs to be seriously reworked by an expert who knows how to write for people who aren't themselves experts already. -- Mwalcoff (talk) 02:02, 10 March 2010 (UTC)
replies: text: Bravo! Go with the NIH definition.108.65.90.133 (talk) 04:07, 28 June 2013 (UTC)
thread_title:  Making this page accessible to most readers 

message: What is the topic sentence even trying to say? To a non-technical reader, this means nothing at all: "In immunology, TCR or BCR or its secreted form antibody." Can someone please either clarify this or remove it? Daemon328 (talk) 16:37, 29 January 2016 (UTC)
replies: text: I came on here to raise the same point. The opening sentence is not a complete sentence. I don't have the scientific knowledge to figure out what's intended, but it would be wonderful if someone who did could fix it. Tigercompanion25 (talk) 18:07, 5 February 2016 (UTC)
replies: text:  and , I just edited the top paragraph and it should now read more clearly. In fact, the first sentence Daemon328 quoted is actually grossly incorrect (BCR is not antigen but antibody, and TCR is a different type of molecule altogether). I had edited this same page not long ago, and so I apologize for not having paid more attention previously; I only noticed this issue after reading your exchange here. themidget17 | babble 21:19, 5 February 2016 (UTC)
replies: text: Thank you , it looks crisp and clear now. :) Tigercompanion25 (talk) 23:48, 5 February 2016 (UTC)
thread_title:  Topic sentence 

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message: Antigen source.  I'm assuming that antigens are trigger proteins that are originally found on viruses and vaccines that are introduced from weakened or dead viruses. These are what antibodies are formed from and reside in the body for future infection reaction? Antigens are not created by the body in response to infection being detected? 2601:187:8080:2310:E08E:5137:1C7A:4BBD (talk) 15:26, 1 January 2022 (UTC)
thread_title:  Antigen source.