Talk:Fluticasone

message: Can we please remove the list of clinical trials. This is an encyclopedia, not a meta-analysis. JFW | T@lk 20:24, 10 May 2005 (UTC)
thread_title: Can

message: Where is fluticasone sold as Beconase? At least here in the US, Beconase is beclomethasone.
:—Preceding unsigned comment added by 69.107.0.225 (talk • contribs)  09:40, 22 September 2006
:Agree likewise so in UK. "Beconae" was added in this edit. I have removed it for now. David Ruben  Talk  13:10, 22 September 2006 (UTC)
replies: text: That addition was mine: in Australia, two preparations of Beconase are sold: a "12 hour" version containing beclomethasone dipropionate, and a "24 hour" version with fluticasone propionate. Ben White 00:45, 14 October 2006 (UTC)

text: In Australia, formulated fluticasone propionate is sold as "Beconase allergy". "Beconase" contains only beclomethasone.  —Preceding unsigned comment added by 198.28.69.5 (talk) 05:10, 12 November 2007 (UTC)
thread_title:  Beconase? 

message: If anybody wants to know the mechanism, Please refer to the following article:
J Allergy Clin Immunol. 2004 Aug;114(2):296-301
Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism.
Dao Nguyen X, Robinson DS.
dtzur@ualberta.ca
:—Preceding unsigned comment added by 129.128.246.146 (talk • contribs)  (18:51, 17 October 2006
:Yet note that this only a possible mechanism - as the abstract states "CONCLUSION: Increased suppression by CD4+CD25+ T cells might play a role in anti-inflammatory effects of corticosteroids in asthma and allergic diseases" David Ruben  Talk  22:21, 17 October 2006 (UTC)
thread_title: Mechanism

message: the article states: "It is marketed with the brand name Flixotide and Flixonase by Allen & Hanburys and Flovent and Flonase by GlaxoSmithKline.". But I have a bottle here (New Zealand) called Flixonase  (TM), and it is made by GlaxoSmithKline and even says Flixonase and the logo are are trademarks of GlaxoSmithKline. Did gsk buy out Allen & Hanburys? or is this just wrong? Onco_p53 10:44, 29 November 2006 (UTC)
thread_title:  Branding 

message: I'm not knowledgeable enough about the markup language to do this myself. This page is about "fluticasone" and the structure is correctly depicted.
However, all the drug products mentioned: Flonase, Flixotide, Flixonase, Cutivate, etc. use "fluticasone propionate". Fluticasone and fluticasone propionate are different chemical entities; the latter has the tertiary hydroxyl propiolated.
As far as I know, there are no drug products out there using fluticasone. Quite often "fluticasone propionate" is referred to as "fluticasone" in shorthand, which is where the confusion arises. Now there is also "fluticasone furoate" which has the tertiary hydroxyl furoylated. 198.28.69.5 02:07, 15 November 2007 (UTC)
thread_title:  Urgent correction 

message: I've split this into three different articles for each of the chemicals involved. This should make everything clearer... LSD (talk) 04:03, 14 January 2009 (UTC)
thread_title:  Split 

message: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147057/
Sorry do not have skills to do this myself.  — Preceding unsigned comment added by 92.18.213.92 (talk) 17:16, 22 December 2015 (UTC)
thread_title:  Please read this and update page. 

message: I'm having trouble finding much of a summary, but the dose ends up being the same and mechanism of action is similar.   The only real difference I'm finding (aside from the age group approved for, which has more to do with what the company decided to market) is a 15 hour half life for furoate vs. 10 for propionate...    This is not unlike various salts of something like amphetamine, where the HCl, Phosphate, Succinate, etc have different half-lives but are no different in mechanism.  Vyvanse is different in that it's a novel time release mechanism using a different structure as a prodrug, to continue with that example.  AFAIK a company can't get new drug approval for a slightly different salt of something (although they did pull a fast one with the utterly pointless isomer / salt ratio in adderall, generics don't even bother following the "template")  or patents would go on forever...     I'm wondering if the same rule *isn't* applied in the case of esters, as they may have a different pharmacological profile, and this one was allowed to slide past, because from where I'm standing it just looks like an attempt to keep patenting the same drug repeatedly.   
This page doesn't do anything to explain this, and it seems like "Fluticasone is a corticosteroid, although the name is more commonly encountered as shorthand for either of two esters of fluticasone, the propionate or the furoate, which are marketed seperately as various medications...." then go on to describe why it isn't used as itself (excretion via the friggin' eye, if correct, might be a good start for research) and brief differences between the esters.   As is the lede is just confusing and makes it sound as though the drug most commonly referred to as this (varies by country, but that's what I'll search for in the US if I'm looking for generic fluticasone propionate) is a mixture of two steroids, which it isn't. A Shortfall of Gravitas (other machine) (talk) 09:16, 16 April 2021 (UTC)
thread_title:  Two Steroids -- Actual Difference?