Talk:Thujone

message: I am concerned by the implications of this page. There is a great deal of literature from France in the 1990's describing the effects of Absinthe but this article simply tries to pawn them off as imagination. I hope that someone will address this article's bias. The lack of science on such an obscure drug should not outweigh decades of writings on the experiences of users. 71.139.160.177 02:40, 28 January 2007 (UTC)
replies: text: What literature would that be?  What if the literature is inaccurate as many previous writings have been shown to be?  What experience by what 'users'? -- Ari 02:49, 28 January 2007 (UTC)

text: Can you explain this bias and provide evidence it is biased?  -- Ari 15:58, 16 November 2007 (UTC)

text: What are these stories?  The Oscar wilde example is a great example of how absinthe's "effects" have grown over the years.  The tale was never actually said by Wilde himself but occurs in a 1949 book.  You can read more here, http://www.oxygenee.com/absinthe-effect/secondaries.html  Every effects story I've read so far seems to be misinterpreted over the years to create the "effect."    Not to mention as pointed out an effect means little about thujone. -- Ari (talk) 03:31, 14 November 2008 (UTC)

text: Hi Discordance, toxic CNS effects are likely different from the psychedelic effect on the brain, and the two should not be conflated.  In Dettling's study, study participants were given 0.28 mg/kg and 0.028 mg/kg, with the former showing attention effects, and the latter showing no effect.  So for a 70 kg human, that would be 20mg, or 1/5th of a bottle of the 100 mg thujone that's available.  Also, since only two levels were tested, thujone might actually be active in humans at doses 2-4 mg, requiring only a shot of pre-ban average 25 mg/L absinthe.  It certainly appears plausible that the amount of thujone in absinthe could affect human brains.  I've restored the "may or may not" portion of the article. Pro crast in a tor (talk) 05:02, 10 January 2013 (UTC)
thread_title: Articles bias

message: The article includes this passage":
"GC-MS testing is important in this capacity, because gas chromatography alone may record an abnormally high reading of thujone because of other chemicals present.[8] Through these tests it has become evident absinthe contains very little thujone."
Is "abnormally" what is meant, or is it rather "erroneously" ?   I suspect it is the latter. This seemingly careless wording radically changes the meaning of this crucial passage.Daqu 02:18, 13 November 2007 (UTC)
replies: text: While it could be abnormal, it is most certainly erroneous (the word that should be used) good catch. -- Ari 03:06, 13 November 2007 (UTC)
thread_title: "abnormally" or "erroneously" ???

message: I wouldn't consider a trip report a valid report, nor does it specifically isolate thujone. -- Ari (talk) 06:52, 5 December 2007 (UTC)
replies: text: This isn't the wormwood page. Without controls they remain interesting but anecdotal reports, wormwood extract is sometimes combined with other substances in those reports as well.  "The only one known to produce pharmacological effects" because many of the other compounds have never been tested.  Sure it does cause effects, I just wouldn't accept erowid trip reports as evidence of said effects. -- Ari (talk) 07:05, 5 December 2007 (UTC)

text: I like that add, thujone rarely gets any interest or study outside wormwood it seems. -- Ari (talk) 07:21, 5 December 2007 (UTC)
thread_title:  Recent Erowid add 

message: Li'l help? Thu-ho-ne? Thuge-own?  —Preceding unsigned comment added by 64.122.63.142 (talk) 17:43, 13 March 2008 (UTC)
thread_title:  Pronunciation 

message: I find it odd that the European Union's maximum allowed levels of thujone are so low. Assuming that the mean lethal dose/body weight in humans is the same as that in mice, you would need to drink 85% of your own body weight in "bitters" or eat 120% of your body weight in "food prepared with sage" in order to get to the 0% fatality level that was confirmed in the study.
That would mean if you weigh 75 kg, and you ate 90 kg of sage-containing foods, you'd still be at the 0% fatality level (and so would not die) even if the food contained the maximum levels the EU will allow. You'd probably die of stomach rupture long before you even come close to dying of thujone.
Weird.  —Preceding unsigned comment added by 70.99.104.234 (talk) 01:51, 23 December 2008 (UTC)
thread_title:  Weird Regulations 

message: As seen in the following gallery, there are more isomers than just α- and β-thujone:
File:Alpha-(+)-Thujon.svg|α-(+)-thujone
File:(-)-alpha-Thujon.svg|α-(−)-thujone
File:Beta-(+)-Thujon.svg|β-(+)-thujone
File:Beta-(-)-Thujon.svg|β-(−)-thujone
This fact is currently not represented in the article. --Leyo 18:17, 2 December 2010 (UTC)
thread_title:  Not just α- and β-thujone 

message: Since toxicity was/is an issue, there should be at least a reference if not a brief mention of the metabolic degradation pathway(s) as well as half-life.  LD100 at 60 ppm (mice) and standard is 35 ppm ?!?  Whats going on here?71.31.147.72 (talk) 21:54, 31 January 2012 (UTC)
replies: text: LD100 is not 60 ppm but 60 mg per kg (of body weight), and EU-maximum is 35 mg per kg (of spirits). In order to consume 60 mg/kg of thujone (means 3600 mg if you weigh 60 kg), you have to drink 102 litres of a hard liqueur containing 35 mg/kg thujone. In one sitting:) – Phoney (talk) 19:43, 1 February 2012 (UTC)
thread_title:  Metabolism 

message: Research from 2016 published in the Journal of Agricultural and Food Chemistry proves that the two other isomers of thujone are present in the essential oil of Sage. These previously unreported enantiomers have not been found in any of the other common thujone containing essential oils to date. 
Williams, J. D.; Yazarians, J. A.; Almeyda, C. C.; Anderson, K. A.; Boyce, G. R. “Detection of the Previously Unobserved Stereoisomers of Thujone in the Essential Oil and Consumable Products of Sage” J. Agric. Food Chem., 2016, 64, 4319-4326.
Thank you for your consideration of this addition.  — Preceding unsigned comment added by 2601:6C0:8100:AEF0:3D8F:FD36:4EA6:97A7 (talk) 00:09, 8 May 2017 (UTC)
replies: text: Supported by http://www.eurekaselect.com/article/99820 — Invasive Spices (talk) 19:08, 3 June 2023 (UTC)
thread_title:  +-alpha and (-)-B have been found in the essential oil of Sage.