Talk:Dopamine receptor D4

message: This article still needs some work. In particular, some chasing of the references mentioned at the end of the one WWW reference provided would probably be useful. I didn't cite any of the studies directly since I didn't read them. Should I have? Most of the rest of the stuff you can find on the WWW is a bit sensational and/or pertains to an article in Time Magazine...not the best place for genetics info. Jeeves 02:05, 9 Jun 2005 (UTC)
thread_title: References

message: "cells with an elongated copy of this gene appear to react more strongly to dopamine molecules." Isn't it the other way around?  In The Tangled Wing by Melvin Konnor (2002) New York NY: Henry Holt  p. 87 it says "Repeats make the protein longer, which makes the receptor weaker, so that it binds less dopamine."  This quote from Konnor matches my understanding, which is that novelty-seeking or thrill-seeking is associated with less production of dopamine; fewer or weaker dopamine receptors; and faster breakdown of dopamine (though I might have some of that wrong), so that high stimulation is required in order to generate enough dopamine to have much of an effect. ☺ Coppertwig (talk) 13:38, 4 May 2008 (UTC)
replies: text: Good catch.  I have replaced more strongly with less strongly in the text and included a citation documenting this fact.  Cheers.  Boghog2 (talk) 14:52, 4 May 2008 (UTC)
replies: text: Actually, the various variants have variable affinities for dopamine in heterologous cell expression systems. There's also differences in expression levels in these systems. I'll try to locate the relevant publications this week... — Scientizzle 18:29, 4 May 2008 (UTC)
thread_title: Elongated receptors response to dopamine

message: a study shows this gene correlates with liberal political attitudes when coupled with an active adolescent social life. --Wongba (talk) 21:54, 28 October 2010 (UTC)
thread_title:  liberal gene 

message: I was reading an article for my developmental psychology class and came across this paragraph saying that "parental quality interacts with the 7-repeat allele of the dopamine D4 receptor gene (DRD4) to influence temperament dimensions related to self-regulation."    The article doesn't go much farther to elaborate, but would this information be helpful to include on this page? Linp11 (talk) 15:46, 1 March 2012 (UTC)
replies: text: That addition, phrased that way, would be confusing (though there should be a mention of DRD4's role). Parental quality is undefined, and it doesn't say what the correlation is (positive, negative, etc.). The article does describe a bit more what the correlation is, that better parenting leads to better effortful control(this would be a good psych article to make) for those with the 7-repeat allele of DRD4. I've added in a section for cognitive development. You are welcome to correct/critique my addition. On a side note, I found the study of a "novel toy" to soothe repeatedly distressed infants somewhat sardonic. If you have any questions, feel free to ask.Smallman12q (talk) 21:14, 1 March 2012 (UTC)
replies: text: Thank you, Smallman12q! Linp11 (talk) 17:47, 2 March 2012 (UTC)
thread_title: DRD4 and Early Development (Parenting gene??)

message: I don't want to be the one who adds an "in popular culture" section to this article. They tend to attract trivia, although the subject here is so specific it's unlikely.
The 2020 thriller Fair Warning by Michael Connelly tells a story about an investigative reporter tracking down an incel serial killer who takes advantage of poor government oversight on the commercial genetic sequencing industry to purchase identities of female victims with DRD4 expressed in their genes because DRD4 is linked to risky sexual behavior. ~Anachronist (talk) 02:32, 19 August 2020 (UTC)
thread_title: In popular culture