Talk:Monoamine neurotransmitter

message: EerieNight (talk) 21:42, 21 June 2010 (UTC)
thread_title: Not all of the listed compounds are neurotransmitters but all are biogenic amines

message: All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.
What neurotransmitters are derived from thyroid hormones? AlphaHelical (talk) 00:58, 9 May 2013 (UTC)
thread_title:  Thyroid hormones 

message: I would very much appreciate a complete list of Monoamine transmitters, as there's at least no prominent one now! Tom W (talk) 18:18, 1 June 2013 (UTC)
thread_title:  Complete List? 

message: http://twin.sci-hub.tw/8805bd6506fd13a62bd64aa462dd4a59/ng2017.pdf - this is the most recent reference that was added to cite the “fact” that melatonin is a neurotransmitter.  It doesn’t state that; it says it’s a hormone and a neuromodulator.  A neurotransmitter is not the same thing as either of these.  The mere fact that melatonin binds to a class of receptors that are expressed in the brain does not make it a neurotransmitter.  There are countless biomolecules that signal through neurons which don’t satisfy the satisfy the criteria for classification as a neurotransmitter.  That includes melatonin because it’s not released into a synapse.
The older primary source - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939688/ - doesn’t classify melatonin as a neurotransmitter either; it refers to melatonin as a “neurohormone” in the very first sentence of the article. Also, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422380/ doesn’t indicate that N-acetylserotonin is a neurotransmitter.  It’s simply a biologically active metabolic intermediate. In any event, please don’t re-add this unless it’s cited by a reliable source which explicitly explicitly states: “melatonin is a neurotransmitter”. Citing a source which is about melatonin but which doesn’t actually directly support the statement is WP:OR.  Seppi333 (Insert 2¢) 05:37, 22 June 2018 (UTC)
replies: text: The last reference added was this one: https://link.springer.com/referenceworkentry/10.1007%2F978-3-540-68706-1_473 First (2010) and second (2015) edition (https://www.springer.com/la/book/9783642361715). It states "Melatonin is a neurotransmitter that participates in the regulation of the sleep/wake cycle. ". Another reference that states the same can be: Medical physiology : principles for clinical medicine. Rhoades, Rodney., Bell, David R., (4th ed ed.). P. 130-131. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2013. ISBN 9781609134273. Gcastellanos (talk) 19:39, 22 June 2018 (UTC)
replies: text: I wish it was a peer-reviewed academic review article that asserted this since that would've provided more context.  Do either of those textbooks indicate the projection nucleus/nuclei of melatonergic neurons?  If we add melatonin to the list of neurotransmitters here, its projection nucleus and output nuclei should ideally be listed in neurotransmitter systems. Seppi333 (Insert 2¢) 21:11, 23 June 2018 (UTC)
replies: text: There are not peer-reviewed articles. A projection system is not needed to be classified as a neurotransmitter, but apparently the release mechanisms in neurons have not been identified yet. Thank you for the discussion. Gcastellanos (talk) 19:26, 9 July 2018 (UTC)
thread_title:  Melatonin