Talk:Cystic fibrosis transmembrane conductance regulator

message: The online book Genes and Disease has it right. In most tissues, transport of chloride ions by the CFTR is followed by movement of sodium ions in the same direction. --JWSchmidt 02:22, 2 October 2006 (UTC)
replies: text: Thank you - sounds good to me. --Arcadian 03:00, 2 October 2006 (UTC)
thread_title: Untitled

message: I've been trying to determine this for quite a while. This article indicates, without citation, that through moving Cl- it produces a concentration gradient for Na and Water. This implies that it is able to move Cl against its concentration gradient, but I have not found evidence of this. There is a new article (http://www.pnas.org/content/107/3/959.short) called 'break a pump, make a channel' that has a great description of the channel in relation to its ABC ancestry. This article NEEDS to be summarized into this wiki, however I am still unable to answer the question of whether it is an active pump or just a channel. While it comes from a family of pumps, I think it is acting only as a channel.   —Preceding unsigned comment added by UberMD (talk • contribs) 10:49, 28 February 2010 (UTC)
thread_title:  Is CFTR a pump or simply a channel??? 

message: Hello, an anonymous user changed the text so that it says that magnesium ions are also conveyed through cell membranes, thanks to this protein, as seen in this diff.
I've fixed the formatting of the added link, but I don't know whether or not the content is accurate. Does anybody else know? Thanks, --Kyoko 21:35, 13 April 2007 (UTC)
replies: text: Thanks for fixing that. --Kyoko 23:09, 6 May 2007 (UTC)
thread_title:  does CFTR transport [[Magnesium|Mg]] as well as [[Chloride|Cl]]? 

message: The article mentions that sodium ions traverse the paracellular pathway in order to balance the electrical gradient.  Is it possible there is one (or more) outwardly-rectifying sodium channels located on the apical membrane?
Ktsharp (talk) 04:52, 13 July 2010 (UTC)
thread_title:  paracellular sodium current 

message: I think it should be more obvious that only for the first nucleotide binding domain (268 of the 1480) a crystal structure is known and that therefor the  structure image should not be in the box. Yak90 (talk) 10:51, 10 December 2013 (UTC)
thread_title:  Structure 

message: Is it possible to measure (in living humans) the physiology of cell functions attributable to the Cystic fibrosis transmembrane conductance regulator (CFTR) gene? 
The CFTR gene codes for a protein that conducts chloride and thiocyanate ions across epithelial cell membranes. Humans with two Delta F 508 mutations of this gene suffer from Cystic Fibrosis. I am interested in the physiology of heterozygous CF carriers who have one copy of the Delta F508 mutation. Do such people suffer any symptoms or diminished functions, perhaps as subtle symptoms of Cystic Fibrosis?
Are there laboratory tests available today that can evaluate the physiology of humans how have one copy of the Delta F508 mutation? Thanks! --Lbeaumont (talk) 13:07, 7 March 2015 (UTC)
thread_title:  Is it possible to measure (in living humans) the physiology of cell functions attributable to the CFTR gene?  

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