Talk:Fluorodeoxyglucose (18F)

message: The formula is not correct (5 carbons only) 5 sep 2006
:It's corrected now. --Ed (Edgar181) 20:01, 5 September 2006 (UTC)
thread_title: Empirical formula

message: Although "fludeoxyglucose" is apparently the official name in the US, "fluoro-" seems to be by far the most common term - the first page of Google results turns up US governmental pages, such as PubMed, giving "fluoro-". I'd say that, for ease of looking-up, we should go with "fluorodeoxyglucose". hollyperidol 07:36, 4 September 2013 (UTC)
thread_title:  Proposed move to 'fluorodeoxyglucose' 

message: In 2005 BTSI said "Most PET users can now purchase FDG for less than $300 per dose, and volume users can negotiate prices closer to $200 per dose. Comparatively, FDG was priced in the range of $600-$700 per dose not too long ago." That is presumably just for the US. - Rod57 (talk) 12:21, 17 July 2014 (UTC)
thread_title:  Cost of FDG for PET 

message: In this passage,"Although in theory all 18F-FDG is metabolized as above with a radioactivity elimination half-life of 110 minutes (the same as that of fluorine-18), clinical studies have shown that the radioactivity of 18F-FDG partitions into two major fractions. About 75% of the fluorine-18 activity remains in tissues and is eliminated with a half-life of 110 minutes, presumably by decaying in place to O-18 to form 18O-glucose-6-phosphate, which is non-radioactive (this molecule can soon be metabolized to carbon dioxide and water, after nuclear transmutation of the fluorine to oxygen ceases to prevent metabolism). Another fraction of 18F-FDG, representing about 20% of the total fluorine-18 activity of an injection, is eliminated renally by two hours after a dose of 18F-FDG, with a rapid half-life of about 16 minutes (this portion makes the renal-collecting system and bladder prominent in a normal PET scan). This short biological half-life indicates that this 20% portion of the total fluorine-18 tracer activity is eliminated pharmacokinetically (through the renal system) much more quickly than the isotope itself can decay. The rapidity also suggests that some of this 18F is no longer attached to glucose, since low concentrations of glucose in the blood are retained by the normal kidney and not passed into the urine. Because of this rapidly excreted urine 18F, the urine of a patient undergoing a PET scan may therefore be especially radioactive for several hours after administration of the isotope.[10]
All radioactivity of 18F-FDG, both the 20% which is rapidly excreted in the first several hours of urine which is made after the exam, and the 80% which remains in the patient, decays with a half-life of 110 minutes (just under 2 hours). Thus, within 24 hours (13 half-lives after the injection), the radioactivity in the patient and in any initially voided urine which may have contaminated bedding or objects after the PET exam, will have decayed to 2−13 = 1/8192 of the initial radioactivity of the dose. In practice, patients who have been injected with 18F-FDG are told to avoid the close vicinity of especially radiation-sensitive persons such as infants, children and pregnant women, for at least 12 hours (7 half-lives, or decay to 1/128th the initial radioactive dose)", the article says 75% for how much is stored in cells, and then it changes its mind to 80%. What is going on, and which one should be kept? 80%, because it and the 20% that get excreted add up to 100%, right? Or is there something I am missing?RafChem (talk) 12:05, 23 April 2016 (UTC)
thread_title:  Percentages don't add up in Mechanism of Action, Metabolic End Products, and Metabolic Rate section 

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