Talk:Metabolomics

message: Metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" (This definition is ridiculous, I think these people have been watching too much CSI! Chemical fingerprint Horatio?)  —Preceding unsigned comment added by 155.198.149.176 (talk) 17:50, 29 July 2009 (UTC)
replies: text: I think perhaps a better definition to start with might be from Oliver Fiehn, i.e. "a comprehensive analysis in which all the metabolites of a biological system are identified and quantified" (Plant Mol Biol (2002) 48:155-71).Amaher (talk) 03:53, 5 January 2010 (UTC)

text: Full ack. Compare to proteomics ("Proteomics is the large-scale study of proteins.", and that is that) and genomics Wikipedia articles. OMICS means "all at the same time". The first three sentences are hideous. --2001:638:1558:9418:A40F:8592:DBDC:EF48 (talk) 12:06, 16 July 2021 (UTC)

text: The additions that you've made look really good. The only other things I think could be added are about matching experimental data to compund libraries, and the statistic and bioinformatic analysis of results. Oliver Fiehn's group at the Max-Planck-Institut has a good list of publications, I can't tell if they're they're fee for public access since I'm on a university network .--nixie 21:32, 16 Oct 2004 (UTC)
replies: text: "Matching experimental data to compound libraries" -- fully agree with you, but it's a big job! Also think your suggestion about data analysis is a good one, I might add some bits in a day or two and let some more experienced biostatisticians correct where necessary. Do you feel like adding some external links, starting with the MPI one (or even just that for now)?? many thanks ... --jake b 21:46, 17 Oct 2004 (UTC)
replies: text: I can quiz a girl in my lab, she's just started her PhD on a metabolomics project, the details are mind boggling- but a basic outline of an experiment would be good.--nixie 01:44, 18 Oct 2004 (UTC)
replies: text: I'm going to add some things on databases, please feel free to add and remove as necessary. Also I'm putting everything in alphabetical order as to not step on peoples toes. FYI I removed a link about proteomics soc as it has very little to do with metabolomics/metabonomics. --Hpbenton (talk) 00:54, 11 January 2009 (UTC)

text: There are now (many many) publications using 1H NMR as a profiling tool -- typically, you obtain a spectrum of a complex mixture, and then use some kind of multivariate data analysis to detect which spectral regions vary (according to e.g. experimental treatment). You can then (try to) relate these back to specific metabolites. HPLC-NMR isn't really close to being a standard technique for metabolomics; main problems are that (a) sensitivity is an even bigger problem, and (b) RPHPLC is poor for highly polar metabolites, i.e. most of them. jake b 10:08, 19 December 2005 (UTC)
thread_title: Untitled

message: I cut these unlinked refs. Some could go back, but they should be justified. 
*Pauling, L.C., Robinson, A.B., Teranishi, R., and Cary, P., Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography, Proc. Natl. Acad. Sci. (1971) 68, 2374-2376.
*Teranishi, R. and Mon, T.R. and Robinson, A.B., Cary, P., and Pauling, L.C., Gas Chromatography of Volatiles from Breath and Urine, Analytical Chemistry  44 (1972) pp 18-20.
*Robinson, A.B. and Pauling, L.C., Quantitative Chromatographic Analysis in Orthomolecular Medicine, Orthomolecular Psychiatry, 1973, ed. D. Hawkins, pp 35-53.
*Robinson, A.B., Partridge, D., Turner, M., Teranishi, R., and Pauling, L.C., An Apparatus for the Quantitative Analysis of Volatile Compounds in Urine, J. Chromatography (1973) 85, pp 19-29.
*Matsumoto, K.E., Partridge, D.H., Robinson, A.B., and Pauling, L.C. and Flath, R. A., Mon, T.R., and Teranishi, R., The Identification of Volatile Compounds in Human Urine, J. Chromatography  85 (1973) pp 31-34.
*Pauling, L.C. and Robinson, A.B., Techniques of Orthomolecular Medicine, First Conference on the Analysis of Multicomponent Mixtures and their Application to Health-Related Problems (1973) 1, pp 1-7.
*Robinson, A.B., Cary, P., Dore, B., Keaveny, I., Brenneman, L., Turner, M. and Pauling, L., Orthomolecular Diagnosis of Mental Retardation and Diurnal Variation in Normal Subjects by Low-Resolution Gas-Liquid Chromatography of Urine, Int. Research Comm. Sys. (1973) 70, p 3.
*Robinson, A.B. and Westall, F.C., The Use of Urinary Amine Measurement for Orthomolecular Diagnosis of Multiple Sclerosis, J. Orth. Psych. (1974) 3, pp 1-10.
*Robinson, A.B., Westall, F.C., and Ellison, G.W., Multiple Sclerosis: Urinary Amine Measurement for Orthomolecular Diagnosis, Life Sciences (1974) 14 pp 1747-1753.
*Robinson, A.B. and Pauling, L.C., Techniques of Orthomolecular Diagnosis, Clinical Chemistry (1974) 20 pp 961-965.
*Robinson, A.B., Orthomolecular Medicine – Diagnosis and Therapy, Proc. 8th Annual Conference National Society For Autistic Children (1974) pp 1-8.
*Robinson, A.B., Looking for Optimum Health: A Guided Tour Through the Linus Pauling Institute (1975) Prevention, pp 89-96.
*Robinson, A.B., Weiss, M., Reynolds, W.E., and Robinson, L.R., Use of Mass Spectrometry for Orthomolecular Diagnosis (1975) Proceedings Twenty-Third Annual Conference on Mass Spectrometry and Allied Topics, pp 182-184.
*Rosenberg, R.N., Robinson, A.B., and Partridge, D., Urine Vapor Pattern for Olivopontocerebellar Degeneration (1975) Clinical Biochemistry 8, pp 365-368.
*Dirren, H., Robinson, A.B., and Pauling, L.C., Sex-Related Patterns in the profiles of Human Urinary Amino Acids, Clinical Chemistry (1975) 21, pp 1970-1975.
*Robinson, A.B., Willioughby, R., and Robinson, L.R., Age Dependent Amines, Amides, and Amino Acid Residues in Drosophila Melanogaster, Experimental Gerontology (1976) 11, pp 113-120.
*Robinson, A.B., Dirren, H., and Sheets, A. and Miquel, J. and Lundgren, P.R., Quantitative Aging Pattern in Mouse Urine Vapor as Measured by Gas-Liquid Chromatography, Experimental Gerontology (1976) 11, pp 11-16.
*Robinson, A.B., Pauling, L.C., and Aberth, W., A Controversy: Diagnosis of Infectious Hepatitis (1977) Clinical Chemistry 23, pp 908-910.
*Robinson, A.B., Molecular Clocks, Molecular Profiles, and Optimum Diets: Three Approaches to the Problem of Aging (1979) Mechanisms of Ageing and Development 9, pp 225-236.
*Robinson, A.B. and Robinson, L.R., Quantitative Measurement of Human Physiological Age by Profiling of Body Fluids and Pattern Recognition (1991) Mechanisms of Ageing and Development 59, pp 47-67.
*Tomita M., Nishioka T. (2005), Metabolomics: The Frontier of Systems Biology, Springer,   
*Wolfram Weckwerth W. (2006), Metabolomics: Methods And Protocols (Methods in Molecular Biology), Humana Press, 
*Dunn, W.B. and Ellis, D.I. (2005), Metabolomics: current analytical platforms and methodologies. Trends in Analytical Chemistry 24(4), 285-294.
*Ellis, D.I. and Goodacre, R. (2006) Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy. Analyst 131, 875-885. DOI:10.1039/b602376m
*Wishart, D.S., Tzur, D., Knox, C., Eisner, R., Guo, A.C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., Fung, C., Nikolai, L., Lewis, M., Coutouly, M.-A., Forsythe, I., Tang, P., Shrivastava, S., Jeroncic, K., Stothard, P., Amegbey, G., Block, D., Hau, D.D., Wagner, J., Miniaci, J., Clements, M., Gebremedhin, M., Guo, N., Zhang, Y., Duggan, G.E., Macinnis, G.D., Weljie, A.M., Dowlatabadi, R., Bamforth, F., Clive, D., Greiner, R., Li, L., Marrie, T., Sykes, B.D., Vogel, H.J., Querengesser, L. (2007) HMDB: The Human Metabolome Database. Nucleic Acids Research 35(Database issue), pp D521-6.
PMID: 17202168
*Claudino, W.M., Quatronne, A., Pestrim, M., Biganzoli, L., Bertini and Di Leo, A.(2007) Metabolomics: Available Results, Current Research Projects in Breast Cancer, and Future *Applications. J Clin Oncol May 14; [Epub ahead of print].
http://lab.bcb.iastate.edu/projects/plantmetabolomics/
*Ellis, D.I., Dunn, W.B., Griffin, J.L., Allwood, J.W. and Goodacre, R. (2007) Metabolic Fingerprinting as a Diagnostic Tool. Pharmacogenomics, 8(9), 1243-1266.
--Kkmurray (talk) 21:58, 28 November 2007 (UTC)
thread_title:  References 

message: I don't want to stand on anyone's toes, but I think the section I've removed from the article and pasted below reads like an advert for one company's technologies and has no references so shouldn't be included.  Otherwise the rest of the article seems quite informative. Terri G (talk) 14:58, 21 November 2008 (UTC)
thread_title: Last section

message: I have made a few edits to this page today - there were several instances where the article stated that metabolomics requires "extraction of metabolites" and "separation of analytes". This is a misleading generalisation since NMR-based methods do not require "separation" or "extraction" of any metabolites - just a spot of D2O and away you go. In general the article itself can do with a massive clean up. --Amaher (talk) 23:57, 7 January 2010 (UTC)
thread_title:  Edits regarding separation methods 

message: The history section of this article is mostly original research and as such does not belong in Wikipedia. This article is about Metabolomics, which means that the History section should detail the background to the field with respect to what people have published within the Metabolomics field. I'm going to clean this up very soon to align this section more closely with Wikipedia guidelines contained in WP:OR--Amaher (talk) 01:59, 11 January 2010 (UTC)
replies: text: OK I have made substantial additions to the History section - based on sources that were written by modern day metabolomics people and published in peer-reviewed journals. I have left the Arthur Robinson section in for now but it needs citations (i.e. ones that specifically relate it to modern day metabolomics - rather than the primary sources) as do a few other things in there. Let me know what you think. --Amaher (talk) 03:08, 11 January 2010 (UTC)
replies: text: I've removed a number of the Robinson refs since it was giving undue weight to this group and thus not in alignment with WP guidelines (WP:NPOV). Although I have left some of the info in and cleaned up the ref list by adding an inline citation since some people in the field have acknowledged the contribution of this group. Although it still problably should only have refs from modern players in the field. I'll come back to this soon.--Amaher (talk) 11:09, 17 January 2010 (UTC)
thread_title: History section

message: doi:10.1186/s13054-016-1222-8 JFW | T@lk 06:13, 30 March 2016 (UTC)
thread_title:  Intensive care applications 

message: Hi - I think it makes sense to add a section for commercial labs. Knowledge of metabolomics is not limited to academia; there are many commercial organizations that provide an excellent source of research of the field, and many commercial labs run within academic institutions themselves. I've included as many as I could find, but please add any others you know of.
DrJaneHarrison (talk) 21:13, 8 January 2019 (UTC)
thread_title:  Commercial labs