Talk:Benzylpiperazine

message: The aborted study has little scientific data or data subsets. The STANZ report was not intended to study BZP but rather was to study the "MRINZ report".  It does not provide useful, solid information on the drug's toxicity.  —Preceding unsigned comment added by Phaser501 (talk • contribs) 02:18, 7 February 2009 (UTC)
thread_title:  Removed STANZ Aborted Study Section 

message: I have taken this drug a number of times. With two or three pills, there is an initial rush sensation and intensity that last four to six hours after taking them, as stated. Some people count this as the entire experience. But if I take three between six and nine at night, I will unquestionably still be awake the next morning between nine and twelve before I can start falling asleep - it is physically impossible to do so before, you simply lie in bed awake. Like MDMA - the first intense set of sensations are not all this drug produces. The majority of the experience won't be composed of that intensity, and this is good in a way as the intensity is also often accompanied by spontaneous but rapidly disappearing sensations such as nausea, depending on the amount consumed - if you feel sick, a lot of it can just be you convincing yourself you feel sick and ignoring it, changing position or location will make it disappear. MDMA and BZP have definite stages to the experience, the intial intense rush (4 - 6 hours), the longest stage brings a wish to focus on things and understand, and then a falling off which will merge onto the end of the latter. I have taken up to six BZP pills in the space of three or four hours. Overall duration is not a great deal longer and neither is the ultimate intensity, but the first few hours of intensity are longer lasting. This quantity is also much more likely to make you feel sick if not carefully taken and, for me, produced a strong headache the next day, although I would accompany a large part of this to being too interested in what I was doing to drink more than a can of coke in the space of the night. My friend suffered a headache after just three and it became apparent to him after around six to nine hours. Hospital strength cocodamol had little effect in removing this for him - although it is possible a percentage of it was psychologically induced. I have experienced more intense migraines spontaneously appear before I began using drugs than I have with intense BZP use.
Drinking and eating in themselves do not become problems, there is simply no wish to do so. You should purposefully buy some cans of soft drink and sweets before hand and put them somewhere obvious so you'll remember. You won't feel the urge to eat or drink them, but the sensation of doing so can be rewarding. Don't try to eat dry foods - we had a bowl of popcorn last over 12 hours, each piece taking minutes to swallow with a dry mouth. Buy high energy things you normally might not let yourself eat. You won't eat a lot, so it's fine for them to be things like chocolate.
The intense effects may only last 4 to 6 hours, but the remainder will last around 18 before you begin feeling closer to normal.
BZP is unlike MDMA in that it lacks the intense emotional depth. You feel relaxed and more connected with people, but there isn't the same willingness to explain yourselves and feelings to each other.
I have never tried snorting raw BZP, but the party pills containing them are not suitable. They produce an intense peppery, burning sensation. Due to the large amount of binder and other ingredients, they take a lot of effort to snort even one. Having inhaled less than one, I developed a minor nose bleed from rubbing my nose so much.
:I've heard from people that small amounts of pure BZP can be insufflated but produce intense burning and irritation/sneezing. This is all anecdotal. --Bk0 (Talk) 02:16, 21 April 2008 (UTC)
thread_title:  Duration, eating, drinking, empathy and snorting 

message: Does anybody have any authoritative ref on the psychoactive duration of BZP? Anecdotally it is reported to be 4-8 hours, but I haven't been able to google anything more substantive than that. Pubmed doesn't yield any definitive kinetic studies and even the DEA website doesn't say anything re: duration. --Bk0 (Talk) 18:06, 12 February 2006 (UTC)
replies: text: I have data just need to track it down - I believe from memory it's half life is 4 hours (I've been researching for my new product V12 - will get back to you on this asap Glen Stollery (My contributions) 18:41, 12 February 2006 (UTC)
replies: text: Hope this helps! <BR /><BR />"BZP and TFMPP are central nervous system (CNS) stimulants. For BZP, doses of 20 to 100mgs produce euphoria, wakefulness and increased vigilance. The duration of action is 6 to 8 hours (Erowid, 1997). A combination of BZP and TFMPP is reported to produce effects similar to MDMA (Bedford, 2001), a substance that is sometimes referred to as an “entactogen”, (meaning ‘to touch within), (Nichols, 1996). Dehydration may be associated with BZP therefore risks of over re-hydration may be present. This effect is not discussed in the literature. However, anecdotes from the community suggest that it can be problematic if used in conjunction with alcohol. The duration of action for a 100mg dose is 6 – 8 hours. However, information from one user/distributor suggests that if 500mgs is taken, then wakefulness can last up to 48 hrs, however such a dose is likely to also cause nausea." <BR />THE EXPERT ADVISORY COMMITTEE ON DRUGS (EACD) ADVICE TO THE MINISTER ON: BENZYLPIPERAZINE (BZP) Glen Stollery (My contributions) 22:43, 12 February 2006 (UTC)
replies: text: Thanks, it still circles back to the unsourced Erowid claim, but that's better than what we had before. --Bk0 (Talk) 00:32, 13 February 2006 (UTC)
thread_title:  Duration ref? 

message: It is often claimed that BZP was first synthesised and/or patented as an anthelmintic in 1944. Can anybody find the patent? 
Wellcome's 1944 patent 9828/44 from the London patent office related to a process for making a wide range of piperazines, not just BZP.
Wellcome states that the purpose of the patent was "to create new compounds" as well as "creating a new and novel way of making piperazine derivatives" there is no mention of application. 
Staack RF, Maurer HH. Metabolism of designer drugs of abuse. Curr Drug Metab. 2005;6:259–74 says "BZP was originally synthesized as a potential anthelmintic agent" and provides no reference. Does anybody have other references for the "anthelmintic" rclaim to show that it is not an error? Stargateinternational 08:08, 8 March 2007 (UTC)
thread_title: BZP as a cattle drench

message: BZP Is no longer legal in Canada   —Preceding unsigned comment added by 75.155.52.84 (talk) 08:31, 17 February 2009 (UTC)
thread_title: Legality in the Canada

message: I was wondering if anyone knew anything about other piperazines like "flippiperazine", "paraperazine", and "fluopiperazine". They are in many party pill brands but I can't seem to find anything about them - not even their chemical formulae, let alone details of their pharmacology. These may have to be in separate articles.
:Ironically even tho it appears to be difficult to find out what they are, a lot of people take them without second thought :-P Nil Einne 03:50, 20 December 2006 (UTC)
thread_title:  Can we have some more info on other stuff. 

message: May be useful . I always remember a New Scientist article a while back which should also be useful. Nil Einne 03:50, 20 December 2006 (UTC)
thread_title:  Link 

message: :Over 20 million pills containing BZP have been consumed in New Zealand...
Citation for this please. Requesting in talk page first - hopefully prior to any need for cite tag in the article. Thanks --SallyScot (talk) 11:33, 2 March 2008 (UTC)
replies: text: Placed a cite in the article, the number is provided by the party pill industry rather than any official count (which would probably be impossible to get). Mr Bungle | talk 22:33, 2 March 2008 (UTC)
thread_title: Attributed deaths

message: This article has a noticeable NZ bias to it, probably because of the recently introduced ban. Maybe someone can make this article more "global".  —Preceding unsigned comment added by 130.217.76.77 (talk) 02:33, 7 April 2008 (UTC)
thread_title: New Zealand Bias

message: This substance is on the list of
Ttg53 (talk) 16:38, 25 March 2009 (UTC)
thread_title: Soon to be delegalized in Poland

message: *
This source could be added. SmartSE (talk) 22:05, 17 February 2011 (UTC)
thread_title:  New source 

message: The article cites New Zealand Med J. 120(1249) "Party on? BZP party pills in New Zealand" as a reference for the metabolism of benzylpiperazine.  This is clearly in error, as the article never mentions metabolism of anything, in any context.  I first became suspicious of the citation because the text states, "[Benzylpiperazine's] metabolism is mainly through the enzymes CYP2D6 and COMT".  Now I don't know about CYP2D6 off the top of my head, but I do know that COMT requires a hydroxyl group in a catechol context to which to transfer a methyl group from SAM.  Benzylpiperazine, of course, has no such hydroxyl group.  Thus, BZP is not a direct substrate of COMT.  Consequently, I am going to delete the entire sentence on BZP metabolism.
Eesnyder (talk) 00:14, 23 March 2011 (UTC)
thread_title:  Metabolism of Benzylpiperazine 

message: Hello fellow Wikipedians,
I have just modified  on Benzylpiperazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20070318042503/http://www.spiritualhigh.co.uk:80/spiritualhigh.co.uk/downloads/Legal-party-pills-in-New-Zealand-report.pdf to http://www.spiritualhigh.co.uk/spiritualhigh.co.uk/downloads/Legal-party-pills-in-New-Zealand-report.pdf
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—InternetArchiveBot (Report bug) 06:18, 31 October 2016 (UTC)
thread_title:  External links modified 

message: Some references have come from sensationalised media reports. The article reads as if the content has been overly influenced by media coverage in New Zealand some time back. This could be moved to a separate section as those references are not scholarly rigorous, and detract from the overall quality of the article.  Dr.khatmando (talk) 04:55, 24 April 2017 (UTC)
thread_title:  Dubious references  

message: Hello fellow Wikipedians,
I have just modified 4 external links on Benzylpiperazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Corrected formatting/usage for http://isomerdesign.com/Cdsa/schedule.php?schedule=3
*Corrected formatting/usage for http://www.spiritualhigh.co.uk/spiritualhigh.co.uk/downloads/Legal-party-pills-in-New-Zealand-report.pdf
*Corrected formatting/usage for http://www.theaustralian.news.com.au/story/0%2C20867%2C20557915-29277%2C00.html
*Added archive https://web.archive.org/web/20131215170432/http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-26.html to http://laws-lois.justice.gc.ca/eng/acts/c-38.8/page-26.html
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 01:50, 21 May 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 7 external links on Benzylpiperazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Corrected formatting/usage for http://isomerdesign.com/Cdsa/schedule.php?schedule=3§ion=2&structure=C
*Added archive https://web.archive.org/web/20071013111558/http://www.nzma.org.nz/journal/120-1249/2422/content.pdf to http://www.nzma.org.nz/journal/120-1249/2422/content.pdf
*Added archive https://web.archive.org/web/20090114182026/http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg1208/mg1208.html to http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg1208/mg1208.html
*Added archive https://web.archive.org/web/20070407080056/http://www.deadiversion.usdoj.gov/drugs_concern/bzp_tmp/bzp_tmp.htm to http://www.deadiversion.usdoj.gov/drugs_concern/bzp_tmp/bzp_tmp.htm
*Added archive https://web.archive.org/web/20081007080620/http://www.nzma.org.nz/journal/118-1227/1784/content.pdf to http://www.nzma.org.nz/journal/118-1227/1784/content.pdf
*Added archive https://web.archive.org/web/20071012221915/http://www.nzma.org.nz/journal/120-1249/2416/content.pdf to http://www.nzma.org.nz/journal/120-1249/2416/content.pdf
*Added archive https://web.archive.org/web/20070928010717/http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON2024549&ssTargetNodeId=389 to http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON2024549&ssTargetNodeId=389
*Added  tag to http://www.homeoffice.gov.uk/documents/cons-2009-bzp/
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 09:11, 18 July 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified one external link on Benzylpiperazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20070716013803/http://www.stanz.org.nz/images/ASSENT81.PDF to http://www.stanz.org.nz/images/ASSENT81.PDF
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 17:32, 9 September 2017 (UTC)
thread_title:  External links modified