Talk:Angiopoietin

message: Mbeez (talk) 19:54, 7 October 2013 (UTC)

message: I am considering developing this page further as part of an educational assignment in Fall of 
2013. If someone else is also working on this, please send me a message and let me know 
soon, so we donʼt duplicate initial efforts in page development. Choidah (talk) 22:49, 6 October 2013 (UTC)
thread_title: 2013, proposed development

message: Our article has had a substantial amount of new material added. Firstly, we have extended the general introduction of the angiopoietin proteins in terms of its mechanisms and relationships with other proteins and growth factors. We then provided more details on the specific mechanisms of angiopoietin-1 and angiopoietin-2 proteins. We focused on the tyrosine kinase pathway and its importance with the angiopoietin protein family. Specifically, the receptor and ligand interactions and the other factors such as VEGFs, PFGFs, and HSC signaling that influence the downstream effects. We then focused on adding more information on the structure of the proteins. Specific facts including the amino acid number, the molecular weight, and the structural domains were added. Lastly, the clinical relevance paragraph was expanded upon. Consequences of angiopoietin dysregulation were discussed which can lead to diabetes, malaria, sepsis, and pulmonary hypertension. Treatment plans involving angiopoietin proteins were also added such as the method for tumor suppression via angiopoietin manipulation. Overall, the amount of new material explained the function and structure of the protein family and how it is relevant during and after development. Ran21 (talk) 05:46, 15 November 2013 (UTC)
thread_title: Summary of additional material on article

message: From josemags
*wiki linking (things that should have a link to another article, but I'm not including what Vicktory7 already said)
**1st paragraph: Growth factors (in the first paragraph, remove the one in specific mechanisms), Cytokines, microvascular permeability (w/ redirect to vascular permeability), smooth muscle cells.
**Specific mechanisms:Phosphorolation, enzymes, integrin and cadherin, extracellular matrix, osteoblastic cells (redirect to osteoblast), ligands, macrophages, glycoprotein, basal lamina, chemokines, autocrine signaling, paracrine signaling.
**structure: Polypeptide. Include a See also line that links to Heterodimers
**Clinical relevance: Well no one knows what a Tek stands for so I dont know what to link that to unless it stands for something previously mentioned in the article which wasnt made clear., squamus cell carcinoma, cardiovascular disease, dialysis, equilibrium (w/ a redirect to homeostasis), sepsis.
*Readability (I would put the structure paragraph before mechanisms to allow for a better understanding of what carries out the mechanisms)
** Intro
*** According to the wiki rules, the very first word should be the exact same as the article title. So it should not be pluralized (I know dumb rule, but I got called out on it by some wiki pro.)
*** Compared to the rest of the article this is the most straight forward and easiest to read. Remember youre not writing for bio majors, youre writing for the common person too. 
*** Is there not a 3D structure for ang-1 and only a structure for ang-2?
*** I agree that the 3rd paragraph should be under specific mechanisms, but I think the 2nd paragraph is fine in the intro.
** Specific mechanisms
*** That last paragraph seems to work best closer to the top.
*** "They are mostly exclusive..." They isn't really expressed. Just change that to the proper noun. 
*** This is how I would break down the sub headings. 1) Functions (essentially the 3rd paragraph from the intro with a bit of expansion) 2. Tie pathway 2a. Tie-2 3. Ang 2 
**** That is a very rough classification of the paragraphs that I provided, but overall that wall of text is hard to maneuver and understand.
**** Move things talking about ang1 and Tie 2 to sub section 2a.
**Structure
*** The sentences here are extremely dense. Space the sentences out with more explanations of critical ideas like what dimerizing does to the structure, or what the super clustering domain is. 
*** "Structurally, angiopoietins have an N-terminal super clustering domain, a central coiled domain, a linker region, and a C terminal fibrinogen-related domain which is responsible for the binding between the ligand and receptor." This should be towards the top of the paragraph.
*** Increase size of the thumbnail. 
** Clinical relevance
*** Definitely like Vicktory7 said separate into sub headings. Possibly like deregulation, (second paragraph has a bunch of different diseases talked about. maybe under one header that links them together, cancer treatment, and sepsis
*** Maybe include a photo that links to one of the diseases mentioned.
* Overall conclusions
** It's a nice article. It's missing some wiki links and could be a little clearer to read, but comparing to what there was here y'all put in a lot of work to make this article like 100x better. Great job.
Josemags (talk) 19:35, 24 November 2013 (UTC)
thread_title:  Peer Review, 2013 

message: I'd like to take a moment to both thank and respond to all of the reviewers! Your input has been incredibly helpful. Your suggestions will be taken into account soon.Mbeez (talk) 19:55, 4 December 2013 (UTC)
thread_title:  Response to Peer Reviews 

message: Sepsis Antibody Shrinks Tumors and Improves Drug Delivery. Dec 2016 relates to the ANG-2, Tie signalling. Could be useful. - Rod57 (talk) 11:09, 11 February 2017 (UTC)
thread_title:  2016 update