Talk:Gentamicin

message: Gentamicin can also be used topically, but this use is not mentioned in the article. — Preceding unsigned comment added by Niqueco (talk • contribs) 00:33, 21 August 2005 (UTC)
replies: text: It's more likely than not a name, rather than a naming convention for a class of antibiotics. There are other 'mycins' (macrolides for example) out there that aren't aminoglycosides. The only thing in common is that they are all derived from Streptomyces species. --Nikbro (talk) 01:24, 13 November 2008 (UTC)
thread_title: Topical inclusion

message: I've proposed that the page Gentamicin toxicity be merged into the "side effects" section of this page.  Any discussion? Agathman (talk) 22:21, 13 April 2009 (UTC)
thread_title:  Merger proposal 

message: While this page isn't terrible, particularly by general wiki standards, compared to most other medications on here this page is really lacking. The side effects take up more than half of the article! I might be able to make some additions at some point, but it is definately in need of some work.McPat (talk) 13:40, 7 July 2009 (UTC)
thread_title:  Disappointed 

message: The article does mention "ototoxic", but it would be good to use language known to the layman, such as "deaf".  —Preceding unsigned comment added by 134.134.139.72 (talk) 20:06, 20 December 2010 (UTC)
thread_title:  Deafness 

message: The schematic structure given at the top is missing a N-methyl substitution (compare it with the ball and stick model which is correct). The C6-N is a secondary amine. It is the amine to the right in the schematic structure. Would someone be able to fix this? Silasmellor (talk) 11:20, 18 June 2011 (UTC)
replies: text: Someone should fix the structures. But looking up the CAS registry number here, it says that it is actually not a pure substance but a mixture of 3 similar compounds, and that's also mentioned on ChemIDplus. Icek (talk) 12:30, 20 September 2013 (UTC)
thread_title: Wrong structure

message: Apologies if this not the appropriate place to ask this question, but the first paragraph of the side effects section deals extensively with side effects to the inner ear, yet the last sentence reads "these side effects are most common when the drug is administered via drops directly to the eye"; should that not read "these side effects are most common when the drug is administered via drops directly to the ear"?
Oreeric (talk) 02:44, 3 July 2012 (UTC)
thread_title:  Gentamicin inner ear side effects caused by drops to the eye? 

message: Can someone contribute a section on Gentamicin's possible use as a treatment for some variants of Cystic Fibrosis (and one for Duchenne Muscular Dystrophy too)? I lack the knowledge and expertise to do so :(  AncientBrit (talk) 04:19, 22 December 2012 (UTC)
thread_title:  Relevance as a Cystic Fibrosis Treatment? 

message: We focused on adding a contraindications and special populations section to the page. These are important points regarding the medication, and it is good knowledge to know in which people it can be used safely or not. It is also a helpful guide for professionals in the healthcare field to know when not to use gentamicin. Our main focus for this paper included organizing it a little better and providing more information that we deemed useful to the general public. Rg cp133 g12 (talk) 04:15, 5 November 2015 (UTC)
thread_title:  CP133 Focus Edits 

message: Yes, this draft submission reflects a neutral point of view and points included were verifiable with cited published material.
Some areas of improvement include:
* Introduction: Try to include some common side effects along with serious side effects. 
* Side effects: Try adding specific information such as percentages if available regarding how likely the side effects will occur (similar to nephrotoxicity and ototoxicity).  
* Side effect – nephrotoxicity: Listing symptoms of kidney damage that patients can easily distinguish at home would be helpful. 
* Contraindications: List out a few examples of the type of hypersensitivity or the serious toxic reaction to look for.  
Echung11 (talk) 06:05, 9 November 2015 (UTC)
thread_title:  CP133 Peer Review 

message: Hello fellow Wikipedians,
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*Added  tag to http://erc.msh.org/dmpguide/resultsdetail.cfm?language=english&code=GEN10A&s_year=2014&year=2014&str=10%20mg%2Fml&desc=Gentamicin%20Sulfate&pack=new&frm=AMPOULE&rte=INJ&class_code2=06.2.2.&supplement=&class_name=%2806.2.2.%29Other%20antibacterials%3Cbr%3E
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thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Gentamicin. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20160304124731/http://www.baxter.ca/en/downloads/product_information/GENTAMICIN(E)_PM_AUG282012_EN.pdf to http://www.baxter.ca/en/downloads/product_information/GENTAMICIN(E)_PM_AUG282012_EN.pdf
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thread_title:  External links modified (January 2018) 

message: The following statement is incorrect:
:Gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the person going into shock from lipid A endotoxin found in certain Gram-negative organisms). 
Gentamicin has not historically been used because these organisms are intracelluar and gentamicin penetration into cells is very poor. In fact gentamicin has been used successfully to treat drug-resistant gonorrhoea. I therefore propose deleting the bracketed word. Gak (talk) 17:01, 8 May 2018 (UTC)
thread_title: Neisseria and Legionella error

message: I changed the irreversible binding to "irreversible" and it was reverted, but I believe that this was done in error. Aminoglycosides such as Gentamicin don't covalently bind to the ribosome so by the biochemical definition of reversible vs. irreversible inhibitors this would make gentamicin a reversible inhibitor. With that said, the reference in the area is from DrugBank, a very thorough and pretty reputable source, and even there it says irreversible in quotes. This is because while it doesn't covalently link to the ribosome, it's binding is very tight and seems irreversible as it kills bacteria. I'd recommend changing irreversible to reversible inhibitor via this reference which shows NMR structural studies on the binding of gentamicin.
Upon looking at common websites and searches there appears to be a lot of references to "irreversible" binding, but no biochemical studies are referenced, only drug databases. I am inclined to think that these are inaccurate based upon the mechanism of action of other aminoglycosides and also the quotation marks in the DrugBank.ca website. I won't change anything yet due to the conflicts online, but my recommendation would be to change it to reversible.
Therazzz (talk) 14:03, 18 March 2019 (UTC)
thread_title: Irreversible binding

message: Hi! I'm a chemist and I will be adding the biosynthesis of Gentamicin. I plan to discuss the mechanism, the unknown genes associated with the expressed proteins and the similarities to other aminoglycoside antibiotic biosynthesis in order too support the theories behind the unknown bits. I also planned to parse through the information already provided to ensure everything is up to-date in accordance with these sources:
I'm new to editing Wikipedia, So I'll probably post some questions here. 
My first question is, are my sources ok for use on Wikipedia? I know I'm not supposed to use anything that is directly researched by the authors, I have a book and the other two sources are reviews.
Thanks everyone!!
-- Cmlambert (talk) 04:35, 30 May 2021 (UTC)
thread_title: Biosynthesis