lflage/wiki-talks huggingface dataset:
Talk:Renewer of Society

message: It is my belief that the article as it now exists is specific enough that it can provide some meaningful context, particularly to Lutherans, whether it is widely used elsewhere or not. I also note that the Calendar of Saints at this point contains only the calendars of two specific Lutheran churches. I am hoping to expand it to include information from other Lutheran churches as well, and believe that it is rather likely that additional names will be added to the list as they are found in other calendars. John Carter 16:35, 17 February 2007 (UTC)
thread_title: Removal of deletion template
Talk:Cell-mediated immunity

message: Not sure where T cell immunity should redirect to. - Rod57 (talk) 12:51, 20 April 2015 (UTC)
thread_title:  Is this the same as T cell immunity or does it include T cell immunity 

message: should this page be merged with innate immunity?  Kaixokkiten (talk) 16:57, 16 April 2016 (UTC)
thread_title: Page Merge?

message: This article could be improved. It inspires no confidence whatsoever. Wodorabe (talk) 20:07, 3 July 2016 (UTC)
thread_title:  This article is ropey 

message: — Assignment last updated by Immune2inaccuracy (talk) 20:27, 21 April 2024 (UTC)
thread_title: Wiki Education assignment: Immunology
Talk:Carbohydrase

message: Can you please cite a scientific reference to support this? Carbohydrases are known to have hydrolytic functions not synthetic ones. In breaking up a complex polysaccharide this will produce smaller molecules of dissacharides but they don't synthesize this.  —Preceding unsigned comment added by 119.95.53.142 (talk) 09:58, 27 May 2010 (UTC)
thread_title:  Carbohydrases  capable of synthesis?
Talk:Mongmong-Toto-Maite, Guam

message: Also needs infobox like other Guam villages. -- Beland 23:10, 16 February 2007 (UTC)
thread_title: Untitled
Talk:Dehydrogenase

message: What is the plural? Dehydrogenases? Dehydrogeni? Ahavahisrael (talk) 13:35, 29 September 2014 (UTC)
thread_title:  Whats is the plural? 

message: I am planning on editing the page to add details about oxidoreductases, the use of NAD+/NADP+, more details on specific examples (alcohol dehydrogenase), and how dehydrogenases are used in the TCA cycle. Here are some of the resources I am planning on using:
1) Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. New York: Wiley, 2006. Print.
2) Goodsell, D.S. "Alcohol Dehydrogenase". RCSB Protein Data Bank. doi:10.2210/rcsb_pdb/mom_2001_1.
3) Hurley, J. H.; Dean, A. M.; Koshland, D. E.; Stroud, R. M. (1991-09-03). "Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes". Biochemistry 30 (35): 8671–8678. ISSN 0006-2960. .
4) "What are Oxidoreductases?". www.chem.uwec.edu. Retrieved 2016-02-02.
5)"Pyruvate Dehydrogenase & Krebs Cycle". www.rpi.edu. Retrieved 2016-02-02.
6)  King, Michael W. (7 January 2016). "Pyruvate Dehydrogenase (PDH) and the TCA Cycle (Krebs cycle)". The Medical Biochemistry Page. Retrieved 1 February 2016.
Jessicook (talk) 03:31, 2 February 2016 (UTC)
thread_title:  Proposed Bibliography for edit of page 

message: 1)	define oxidoreductases (using source 4 & 1 from above)
a.	distinguish between a dehydrogenase and a reductase
2)	In depth description of dehydrogenase
a.	Reactions they catalyze
b.	How to identify a dehydrogenase
c.	What the reaction looks like (with a picture)- using chemdraw
3)	Use of cosubstrates (source 1)
a.	NAD+/NADP (source 3 & 1)
b.	FAD (source 1)
c.	When each is used (what type of reactions with examples)
d.	How they work
4)	Detailed example of a dehydrogenase reaction
a.	Either alcohol dehydrogenase or TCA cycle dehydrogenase (source 5,6 or 2)
Jessicook (talk) 17:37, 8 February 2016 (UTC)
thread_title: outline for proposed edit
Talk:Sånta Rita-Sumai, Guam

message: Needs infobox like other Guam villages. -- Beland 23:11, 16 February 2007 (UTC)
thread_title: Untitled
Talk:Bombardier ALP-46

message: Is this article really about the ALP-46? AFAIK the ALP-46 is a derivative of DBAG Class 101 built by Bombardier Transportation.  --81.173.140.255 23:12, 16 February 2007 (UTC)
replies: text: The ALP-46 is a derivative of the 101, but internally is an entirely different locomotive worthy of its own article. I added a citation tag since some information was added since my last edit which cannot be verified. Jimzim66 02:17, 5 March 2007 (UTC)
thread_title: ALP-46?

message: I notice that the "Total production" stat in the infobox says "30", but both the numbering and the text of the article only make mention of 29. Is the infobox stat wrong (likely), or is there a mysterious unit unaccounted for (an undelivered prototype, perhaps)? —LrdChaos (talk) 03:58, 18 June 2007 (UTC)
thread_title:  "Total production" stat 

message: It’s almost been 20 years Since the ALP 46 Locomotives have been in service so now what’s the future for them? Will they get a midlife overhaul or get replaced by Additional ALP 45DPs completely or new locomotives in the next 5 to 10 years? 2601:8C:417F:B80:7D3E:E8F:33FD:51A2 (talk) 23:57, 6 January 2023 (UTC)
thread_title:  Future of NJ Transit Alp 46 Locomotives?
Talk:Sinajana, Guam

message: Needs infobox like other Guam villages. -- Beland 23:12, 16 February 2007 (UTC)
thread_title: Untitled
Talk:Talo'fo'fo, Guam

message: Needs infobox like other Guam villages. -- Beland 23:12, 16 February 2007 (UTC)
thread_title: Untitled
Talk:Tamuning, Guam

message: Needs infobox like other Guam villages. -- Beland 23:12, 16 February 2007 (UTC)
thread_title: Untitled
Talk:Cellulosome

message: It's not a genus or anything, so it should just display normally. Equinox (talk) 19:43, 10 September 2015 (UTC)
thread_title:  Why does the page title show up in italics? 
Talk:Yona, Guam

message: Needs infobox like other Guam villages.
===Does anyone have photos of the Japanese tanks in the area near the Segua river?===
I think they would be a good addition to this page, as long as the photos are copyright free. Sprinkler21 (talk) 05:41, 10 June 2011 (UTC)
thread_title: Untitled

message: I think they would be a good addition to this page, as long as the photos are copyright free. Sprinkler21 (talk) 05:41, 10 June 2011 (UTC)
thread_title: Does anyone have photos of the Japanese tanks in the area near the Segua river?
Talk:Lancashire Landing Cemetery

message: Article reassessed and graded as stub. --dashiellx (talk) 18:20, 13 June 2008 (UTC)
thread_title:  WikiProject Military history/Assessment/Tag & Assess 2008 
Talk:Indefeasible rights of use

message: I marked the word inrefusiable with a  in this article because I don't think it is a real word, but I don't know what it was supposed to be.  I can't find this in any dictionary, and it shows up in a Google search only for this article.  Can someone fix this?  CosineKitty (talk) 23:55, 28 June 2008 (UTC)
thread_title: Inrefusiable?

message: ğğğğğğğğhpjpocpogvoıx,kykkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkk  —Preceding unsigned comment added by 92.63.8.196 (talk) 20:00, 2 October 2008 (UTC)
thread_title:  ,iiiiiiiiiiiiiiiiiiiiiiiiiii,,,,,,, 

message: The accounting of IRU is using operating lease rather then fincial(capital)lease, the main reason is the IRU holder has the right of use ONLY but never own the assets during or at the end of the least period.  58.27.115.117 (talk) 12:25, 25 November 2008 (UTC)
thread_title: IRU Accounting
Talk:Collagenase

message: Clostridium. They are an exotoxin (a virulence factor)and help to facilitate the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs. 
added this to the article 
source Tortora, Gerard J. Microbiology: an introduction. Gerard J. Tortora, Berdell R funke, Cristine L. Case- 9th ed. 2007 Pearson Benjamin Cummings. J1j2j3 (talk) 19:50, 12 December 2007 (UTC)
thread_title: Untitled
Talk:STS-89

message: This page was written before STS-89, a very long time ago, and never updated.  It is in serious need of an update.  --Cromwellt 17:18, 16 Feb 2007 (UTC)

message: I believe STS-89 was the first mission to fly with a Block-IIA SSME, using the Large Throat Main Combustion Chamber design. If so, that is highly notable and should be mentioned prominently in this article. Could someone double-check that? My source is "Wings in Orbit", page 163. 50.46.147.214 (talk) 19:48, 12 May 2014 (UTC)
thread_title:  First Block-IIA SSME?
Talk:Glycogen debranching enzyme

message: I changed the article to state debranching enzymes instead of enzyme.  There are cases where one enzyme does both functions, and cases where it is two separate enzymes.  If someone with more knowledge can re-write the article to distinguish these two cases, it would be appreciated.  Hichris (talk)  —Preceding undated comment was added at 16:09, 26 September 2008 (UTC)
thread_title: Untitled
Talk:Dehydratase

message: 1. This article does not have any citations so I don't know where this information came from nor how accurate it is. This also creates the problem of having no leads for other sources with more information on this enzyme.
2. This article also does not have any diagrams of the protein nor any reference to its discovery and history which would be helpful to have since it would put in perspective the information of what we know about this protein. --Kj18vish (talk) 19:09, 22 October 2016 (UTC)
thread_title: Untitled
Talk:Demethylase

message: The current written scheme (see below) is not entirely correct, as only one of the two possible mechanisms includes formation of a hydroxymethyl intermediate. IMHO it should be removed, as now a graphical scheme covering both mechanisms is available. 
:hydroxylation: R2NCH3  +  [O]   →   R2NCH2OH
:loss of formaldehyde: R2NCH2OH   →   R2NH  +  CH2O
--Hbf878 (talk) 08:30, 25 September 2019 (UTC)
thread_title:  general demethylation reaction
Talk:Deoxyribonuclease

message: I floated the idea of the drug 'lab', basically DNase taken internally. Had that been studied at least in isolated neurons? 24.146.226.25 (talk) 00:22, 21 May 2011 (UTC)
thread_title:  'Lab' 

message: — Assignment last updated by Izcabral (talk) 18:50, 13 October 2022 (UTC)
thread_title: Wiki Education assignment: CHEM 455_505 Special Topics in Biochemistry - Nucleic Acids Biochemistry
Talk:Dihydrolipoyl transacetylase

message: The reason I added the  infobox and moved the "Asymmetric unit.jpg" graphic from the  box is that the scope of the former covers all dihydrolipoyl transacetylases from bacteria to humans while the scope of the later is of human only.  It did not make sense to add a graphic of a bacterial protein to a human infobox.  
While I was at it, I also merged in the contents of dihydrolipoyllysine-residue acetyltransferase into this article since both articles concern the same enzyme.  Finally I replaced the  with a more information rich  template that is less anthropomorphic. Cheers.  Boghog (talk) 20:16, 17 May 2010 (UTC)
thread_title:  Infoboxes, etc. 

message: Dear Boghog2,
Thanks so much for working so hard to make Wikipedia's protein and enzyme pages so helpful, accurate, and nicely laid out.  You're really doing the community a huge service.  My students are editing Wikipedia pages as part of a class project, and are being graded based on their efforts.  It will make my work much easier if you could hold up on fixing up their work until after Friday the 21st.  Please let me know if this seems reasonable to you.  Again, I personally greatly appreciate the effort you've obviously put in to helping out the entire biochemical community.
Best,
Alex Dunn
[email redacted, visible via dif]   —Preceding unsigned comment added by 171.66.82.245 (talk) 02:15, 18 May 2010 (UTC)
replies: text: I apologize for complicating your work. As stated in more detail here, I will hold off further edits until this weekend. Please carry on!  Boghog (talk) 04:36, 18 May 2010 (UTC)
thread_title:  Stanford Biochemistry class project 
Talk:Dihydropyrimidine dehydrogenase

message: According to ExPASy, there is only one human isozyme with  activity (DPYD), hence I supporting merging DPYD into this article. Boghog (talk) 11:39, 15 April 2017 (UTC)
replies: text: Klbrain (talk) 20:07, 6 October 2018 (UTC)
thread_title:  Merger
Talk:Bolivian Water Wars of 2000

message: This article covers the same topic as Cochabamba protests of 2000, I made this page because I didn't know there was already an artilce on this topic as there was no links to it at either the Banzer, Morales, or Quispe pages. Also the name of the pre-existing article was odd as under naming conventions it shoould have included the term Water Wars as that was what the media reffered to the event as, when I searched for that name there was nothing so I began the page. It seems most of the information at the pre-existing page is already included here, but that page has more external links. Please review the contents of both pages.--Wowaconia 23:17, 16 February 2007 (UTC)
replies: text: Yes merge, and rename "Cochabamba Water Wars of 2000".  Fredwerner 04:36, 6 April 2007 (UTC)
thread_title: On call to merge

message: As there was another event called Water Wars in Bolivia in 2003 the use of the year here is important to distinguish the two events.--Wowaconia 23:27, 16 February 2007 (UTC)
thread_title:  On use of name in the year 

message: The first sentence says it all: "The Bolivian economy had been ravaged by greedy generals ever since the Army coup in 1964 overthrew the government. " Why "greedy"? I mean, this isn't only against NPOV policy, although I'm sure you could actually back up this with sources (and I won't be the one to contradict you), but it only makes 6 signs more to the article, one word, and 20 readers less. Go for the facts, simplify, we don't need the whole story about how the kid got killed: knowing a military killed him, and his name, is enough. No cynism, but protests are violent in Bolivia (some 80 killed during the Bolivian Gas War, with military helicopters shooting on El Alto ). There is no need for literature here, the facts are bright (or obscure) enough. Furthermore, I've tried to simplify the sections, they're is just to many of them. Maybe using sub-sections would help - in any cases, having subsections with only two sentences is a bad idea. Despite these remarks concerning lay-out, great job! I do believe however that this should be merged to Cochabamba protests and not the reverse. Tazmaniacs 23:51, 13 March 2007 (UTC)
replies: text: Another note: Army coup of 1964 should lead to History of Bolivia#1960-1970, in order to let place for the creation of History of Bolivia from 1964 to 1982 (for example). Linking directly to presidents and biographies will render the process of creating a more detailed account of Bolivia's history very difficult. If you do find that there is more information on the biographies, why not just copy-paste them to Contemporary history of Bolivia (spanning from 19th century - Colonialism and pre-colonialism takes more than 2/3 of History of Bolivia, so such an article would be justified...). Actually, I'll start it! For you to fill :) Tazmaniacs 23:57, 13 March 2007 (UTC)
thread_title:  Go for the facts
Talk:Exopeptidase

message: ==Untitled==
Angiotension converting enzyme is called an exopeptidase but it is found in lung capillaries according to the wiki article under that name. Someone is wrong about something.
71.127.17.39 (talk)  —Preceding undated comment was added on 04:44, 26 February 2009 (UTC)
thread_title: =Why limit the definition to pancreatic enzymes

message: Angiotension converting enzyme is called an exopeptidase but it is found in lung capillaries according to the wiki article under that name. Someone is wrong about something.
71.127.17.39 (talk)  —Preceding undated comment was added on 04:44, 26 February 2009 (UTC)
thread_title: Untitled
Talk:Enolase

message: The article says human has 5 isozymes of enolase, while it lists only 3. CopperKettle 11:05, 14 May 2007 (UTC)
replies: text: I searched on Google Scholar, and most results talk of 3 isozymes (although they do not say if there are only 3 or if there are more). And this source from 1983 talks about 4 forms: alpha alpha, beta beta, gamma gamma and alpha gamma. Will check some textbooks too. - TwoOars 22:26, 20 August 2007 (UTC)
thread_title:  5 of 3 isozymes? 

message: Enolase and phosphopyruvate hydratase are synonyms (http://brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.11). The enzyme's function is uniquely described by its EC number. Phosphopyruvate hydratase seems to be more universal in scope, while this article is rather human-centric. The two should be combined into one article.134.169.106.141 (talk) 16:01, 1 July 2013 (UTC)
replies: text: Support merger under the name Enolase as that article is more developed. ComfyKem (talk) 17:31, 1 July 2013 (UTC)

text: Done. 134.169.106.133 (talk) 13:40, 20 July 2015 (UTC)
thread_title:  Merge with [[Phosphopyruvate hydratase]] 

message: The references provided do not support the claim that inhibition of enolase is responsible for the cariostatic effects of fluoride. One study source only describes the extent of water fluoridation in the US, and the other only shows in vitro inhibition of the enzyme by fluoride but does not claim that those concentrations would be achieved by consuming fluoridated drinking water. Most of the cariostatic effects of water fluoridation are believed to be through the formation of acid-resistant fluorapatite in enamel.141.209.57.178 (talk) 16:39, 12 July 2019 (UTC)
thread_title:  Fluoride
Talk:Kit-Cat Club

message: I added the cleanup template, the first time in my wiki-life... because the article is structurally a real mess. It has information about the famous toasting in two different places, and many incongruous clashes between chocolate bars and revolutions, etc.  The material that has been gradually added is generally good, but it has been put in any old place. I'll try to be back and re-structure the article myself, if I can find the time. When I edited it in 2004, all the material was  sourced to Kerry Downes... I have no idea where most of the rest comes from, unfortunately. Bishonen | talk 23:25, 16 February 2007 (UTC)
replies: text: Another example is how the introduction gives the origin of the club's name, after which the following paragraph under "Origins" states that "The origin of the name "Kit-Cat Club" is unclear". Joachim 12:29, 11 April 2022 (UTC)

message: This article needs to be reworked (rewritten?) to take into account Ophelia Field's recent book (which I have added to the references). m.e. (talk) 05:15, 24 February 2010 (UTC)
thread_title:  Ophelia Field's book
Talk:Enzyme multiplied immunoassay technique

message: copied the following here per PRESERVE as it is unsourced:
;from lead
First introduced by Syva Company in 1973, it is the first "homogeneous immunoassay" to be widely used commercially.
Homogeneous immunoassays can be carried out using exceptionally simple and rapid mix and read protocols. The most widely used applications for EMIT are for therapeutic drug monitoring (serum) and as a primary screen for abused drugs and their metabolites in (urine). The original US patents covering major aspects of the method, 3,817,837 and 3,875,011, have expired although US patent 6,455,288 that covers a major improvement is still valid. While still sold by Siemens Healthcare under its original trade name, EMIT, assay kits with different names that employ the same technology are supplied by other companies.
Like all immunoassays, EMIT uses antibodies that are specifically designed to bind the molecule(s) of interest (analyte) without binding to other substances in the sample. Its unique feature is the ability to detect this binding without resorting to a cumbersome separation of the bound component. This is accomplished by including (in the mixture of antibodies and sample) an enzyme that is attached to the analyte being tested for.  Antibodies that do not become bound to the sample drug bind instead to this analyte-bound enzyme. The analyte-bound enzyme is designed so that when antibodies bind to its analyte portion, the enzyme is deactivated.  Two general examples are here given:
#If a high amount of sample analyte is present, this sample analyte will bind a large portion of antibodies leaving a large portion of the analyte-bound enzymes free in solution.  Much substrate will be converted by high concentration of free enzyme.
#If a low concentration of sample analyte is present, this small concentration of sample analyte will bind only a small portion of the antibodies, leaving a large portion of the antibodies to bind the analyte-bound enzymes and deactivate them.  In this case, much of the substrate will not be converted.
;Technique
# Combine a sample suspected of containing the drug of interest with a solution containing a known concentration of antibody and the enzyme substrate.
# After a short period (usually less than a minute) to allow binding, add a known concentration of the conjugate.
# Measure the rate of appearance of color or fluorescence.
# Determine the drug concentration by comparing the observed rate to the rates produced by known concentrations of the drug.
-- Jytdog (talk) 03:49, 21 December 2016 (UTC)
thread_title:  unsourced
Talk:Prolyl isomerase

message: I beleive that FKBP and Prolyl isomerase articles are essentially describing the same concept/entity and that a single merged article would be beneficial. Alexbateman (talk) 11:55, 25 July 2010 (UTC)
replies: text: Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin.  Hence I think the prolyl isomerase article should concentrate on the reaction while the FKBP artilce concentrates on the family of sequence and structurally related proteins.  Boghog (talk) 06:33, 15 July 2011 (UTC)
thread_title:  Merger
Talk:Factor XII

message: I changed the Deficiency section to reflect factor XIIa's apparent lack of involvement in thrombin formation.  
Rileypaulw (talk) 22:33, 7 January 2009 (UTC)
thread_title:  Deficiency 

message: Another indication that we've been all wrong about factor XII for decades. The lower the FXII activity, the higher the risk for coronary heart disease  JFW | T@lk 21:22, 22 November 2007 (UTC)
thread_title:  Heart disease 

message: Search word yii redirects to this article. I think it should not be so Ssavilam (talk) 07:09, 5 June 2010 (UTC)
thread_title:  Redirection from  YII 

message: There were found links to FXII and multiples sclerosis wouldnt it be interesting in the wiki article ? Can someone maybe research this with a little more background knowledge ? It would also be interesting to know which substances influence that factor. like infestine-4  — Preceding unsigned comment added by 87.191.19.138 (talk) 16:37, 6 September 2016 (UTC)
thread_title:  link to multiples sclerosis found 

message: Review in Blood about the physiological function of F XII and potential therapeutic implications. doi:10.1182/blood-2012-07-292094 JFW | T@lk 22:41, 25 November 2012 (UTC)
replies: text: Another review discussing the exact function of FXII doi:10.1111/jth.13383 JFW | T@lk 13:11, 20 June 2016 (UTC)
thread_title:  Review
Talk:Protein Z-related protease inhibitor

message: JFW | T@lk 21:35, 26 March 2007 (UTC)
thread_title:  Clinical relevance 

message: At the moment, Protein Z-dependent protease inhibitor redirect to this page. However, Protein Z-dependent protease inhibitor is the real name of this protein. 20 times more hits in Google Sccholar, 15 times in Google. We should swap the pages. NicGambarde (talk) 10:53, 9 December 2021 (UTC)
thread_title:  Move to Protein Z-dependent protease inhibitor