Talk:Management of Parkinson's disease

message: What about gene therapy for parkinson's disease?
75.16.79.22 00:32, 30 June 2007 (UTC)
thread_title: Comment

message: I have done a major revamping of the article copying info from the main article, since in general it was more complete and referenced. 
The section on nutrients was really poor, with unbalanced, unreferenced content. Nevertheless since some items could be of use in the future if properly sourced and balanced with secondary sources I move the whole section here:
:Nutrients have been used in clinical studies and are widely used by people with Parkinson's disease in order to partially treat Parkinson's disease or slow down its deterioration.  The L-dopa precursor L-tyrosine was shown to relieve an average of 70% of symptoms. Ferrous iron, the essential cofactor for L-dopa biosynthesis was shown to relieve between 10% and 60% of symptoms in 110 out of 110 patients.  More limited efficacy has been obtained with the use of THFA, NADH, and pyridoxine—coenzymes and coenzyme precursors involved in dopamine biosynthesis. They now constitute largely experimental methods and former treatments rather than common medical practice. Vitamin C and vitamin E in large doses are commonly used by patients in order to theoretically lessen the cell damage that occurs in Parkinson's disease. This is because the enzymes superoxide dismutase and catalase require these vitamins in order to nullify the superoxide anion, a toxin commonly produced in damaged cells. However, in the randomized controlled trial, DATATOP of patients with early PD, no beneficial effect for vitamin E compared to placebo was seen Coenzyme Q10 has more recently been used for similar reasons. MitoQ is a newly developed synthetic substance that is similar in structure and function to coenzyme Q10. However, proof of benefit has not been demonstrated yet.
--Garrondo (talk) 20:03, 5 January 2011 (UTC)
thread_title: Major revamping

message: The second to last paragraph here is copied directly from a 1989 paper's abstract - "the on off phenomenon" found  here . This doesn't provide the reader with much useful information and is likely out of date. Can a specialist provide any more useful (pathogenesis etc.) information? Medi1101 (talk) 17:46, 23 May 2012 (UTC)
thread_title:  Levodopa paragraph 

message: in this dif away back in 2011 the ref name "Nice-pharma" got trashed by providing two different versions of the citations under the same name.   This dif, changed just one of the already-existing multiple citations.   Both the versions of the citation in 2011 used this URL: http://guidance.nice.org.uk/CG35/Guidance/pdf/English which now redirects to something different, namely https://www.nice.org.uk/guidance/CG35.   The original URL is archived at the internet archive at https://web.archive.org/web/20110807071956/http://guidance.nice.org.uk/CG35/Guidance/pdf/English -- it is a landing page where you can find the full pdf.   The current similar page at the NICE site is here: https://www.nice.org.uk/guidance/cg35/evidence - the link to the full pdf is there.   
The recent dif attempted to replace the URL with https://www.ncbi.nlm.nih.gov/books/NBK48513.   The full pdf is what is cited in the ref, and is here at the NICE site; there is no reason not to use that URL.  I have done that, and add a note that it was reviewed in 2011 and that it is in the process of being updated.  This is a really old ref per WP:MEDDATE...  Jytdog (talk) 19:35, 30 November 2016 (UTC)
thread_title:  ref names 

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thread_title:  External links modified 

message: I would very carefully like to introduce a section on alternative medicine, strictly limited to review articles and meta analyses as it is quite a rabbit hole. Has this been attempted already or is there a reason it hasn't been done already? I enjoy sandwiches (talk)  00:41, 17 February 2019 (UTC)
thread_title: Alternative medicine

message: Perhaps there should be a section on external devices which reduce tremors or reduce the impact of tremors as per these?  Aoziwe (talk) 08:46, 5 March 2019 (UTC)
thread_title:  External devices