Talk:Caffeine/Archive 2

message: At the present time (see sig), the information on toxicity seems rather inconsistant. We have the following statements:
* Intravenous LD50 > 32 g
* Oral LD50 is 13-19 g
* Oral LD50 is 150-200 mg/kg, or 7.5-10 g for a 50-kg person
The big question here is, how can intravenous LD50 be greater than oral LD50? Vectro 04:31, 8 May 2006 (UTC)
thread_title: Toxicity

message: According to some sources, Espresso is the form of coffee with the least amount of caffeine, the explanation being that when making an Espresso, the water comes into contact with the coffee powder only a very short time.
For example, The Economist (admittedly no scientific publication) writes:
:(...) it [Espresso] contains less caffeine than almost any other form of prepared coffee.
See Espresso coffee (The Economist)
* I agree with the anon above. The National Geographic  article on caffeine stated that espresso has around 40mg per ounce, not 100mg. I am going off of memory as I do not have a subscription, but it seems what whomever posted the espresso content was making things up. Espresso is a darker bean, roasted longer (which reduced caffeine content) and it contains less water, which reduces caffeine content due to the fact that it is barely water soluble (which is why we need to heat our water for coffee and tea). 
* Also, I am skeptical of most of these caffeine content figures, there are no sources cited.
Reid 20:34, 7 February 2006 (UTC)
replies: text:  The article cites robusta. This variety has more caffeine than the most common variety used for taste: arabica. Thus, the amount given might be OK. Jclerman 22:00, 7 February 2006 (UTC)
thread_title:  Caffeine content of Espresso vs. regular coffee 

message: I don't know where this fact belongs, and I don't have a reliable reference, but as I understand it, in Canada there are restrictions on what drinks can contain caffeine - you can't add it to clear pops or juices, only colas.  Canadian Mountain Dew has no caffeine.  This is being circumvented by adding guarana... --Andrew 15:41, Apr 24, 2005 (UTC)
Of course, Guarana actually CONTAINS caffeine itself, but via loopholes in both Canada and the U.S., it doesn't need to be labeled as caffeine per se because it's within the guarana, a natural substance, as opposed to being in the form of pure caffeine powder, which is what's normally added to soft drinks. So guarana Mountain Dew will actually have caffeine, but consumers won't be told this.
* In fact, Mountain Dew Energy, sold in Canada, contains caffeine as a medical ingrediant, listed as such - the regulartions about this sort of thing are a little looser than they used to be. WilyD 22:37, 1 March 2006 (UTC)
thread_title:  Caffeine regulation in Canada 

message: The article mentions, However, this is impossible; caffeine is an achiral molecule with no chiral centers, and therefore has no stereoisomers.. If I understand the phrasing correctly that caffeine is achiral because it has no chiral centers, then that's contradicted by the article on chirality which states, It is also possible for a molecule to be chiral without any specific chiral centers in the molecule. The articles on axial_chirality and planar_chirality support that notion, as well. Can someone verify the article's assertion from scientific sources like a peer-reviewed journal article or review on caffeine? - Gyan 02:36:10, 2005-09-04 (UTC)
:Take a look at the caffeine molecule. It's obvious that there are no chiral centers  - all tetravalent atoms (i.e. carbon atoms) have at least one double bond or two identical neighbors. There are no chiral axes either: The only potential chiral axis is between the two central carbon atoms which share a double bond. The ligands of those carbon atoms, however, cannot be inverted without altering the molecule's connectivity. As for potential planar chirality - the caffeine molecule is pretty much planar, so that makes no sense at all. If the achirality of this simple molecule is still disputed, however, I challenge people to come up with a depiction of an actual stereoisomer (e.g. "mateine" or "guaranine"), then we can discuss whether that's actually structurally identical and exhibits a different configuration -- there's simply a limit on how much the burden of proof should be allowed to shift in this debate. Aragorn2 20:14, 18 December 2005 (UTC)
replies: text: Nitrogen can be a stereocenter if it's locked in one tetrahedral geometry (3 single bonds + 1 lone pair; a high energy barrier to inversion). However, that is not the case in caffeine. The lone pair on each of the nitrogen that is written with three single bonds is involved in resonance with the adjacent carbonyl. This makes the bond between N and C somewhat like a double bond: the nitrogen is sp2 hybridized, and is therefore planar not stereogenic. Even in molecules where the nitrogen lone pair is not involved in resonance, the barrier to inversion of the tetrahedron is very low, so that one has a rapidly interconverting mixture and cannot handle each enantiomer separately. Therefore, although there is technically a stereocenter at N, one doesn't usually consider such molecules as "chiral" in a practical sense for ordinary organic chemistry. DMacks 07:51, 24 March 2006 (UTC)
thread_title:  Stereochemistry of Caffeine 

message: # Melting point: 238 °C
# Boiling point: 178 °C (sublimes)
Isnt it meant to be the other way round ? When i did Chem things normally melted and then boiled? --2mcmGespräch 20:10, 26 October 2005 (UTC)
replies: text: Boiling/sublimation point is highly dependent on pressure, whereas melting point is much less sensitive to pressure. If you were to operate at a pressure where sublimation does not occur, you would see an ordinary solid-liquid transition. That is, as you raise the pressure, the sublimation point goes up (as usual: higher P leads to higher bp). Eventually, the sublimation point will be higher than the mp: you'll have a span of temperatures "above mp but below bp"--a distinct liquid phase. Visit Phase diagram for more info. DMacks 20:02, 22 March 2006 (UTC)
thread_title:  Melting / boiling points ? 

message: How is caffeine used as a pain relief enhancer in medicines like Exedrine? 153.104.16.114 01:50, 11 November 2005 (UTC)
replies: text: It might be related to the action of caffeine on the adenosine receptors which mediate(s) antinociception, thus helping with the analgesia of muscle and bone. Hence, it might work alone, without aspirin or acetaminophen (paracetamol) in the formulation. Don't consider this medical advice, just my unproven hypothesis. Jclerman 03:10, 11 November 2005 (UTC)
replies: text:  I have read that caffeine has no documented enhancing effects when used with pain relievers. However, this article states ""There is no evidence that caffeine relieves pain, but it can enhance the effects of aspirin, possibly by lifting a person's mood," says Michael Weintraub, M.D., director of FDA's Office of OTC Drug Evaluation." PrometheusX303 13:39, 15 January 2006 (UTC)

text:  It is also useful to consider that caffeine withdrawl is a very common cause of headaches, so to add it to pain relief pills is a fair method of covering bases. Of course, that's speculation, and is not appropriate for the article proper. – ClockworkSoul 16:22, 16 January 2006 (UTC)
thread_title:  Usage in Pain Relief Pills 

message: As an organic chemistry student, I'm finding the drug page on caffeine to be inadequate. Is someone willing to write an organic compound article, following that format (see dichloromethane)? I don't do much of this sort of thing, but if someone were to write Caffeine_(chemistry) or whatever the standard would be, I think it would be helpful. --horsedreamer 18:36, 16 November 2005 (UTC)
replies: text: Well, with your credentials you should certainly be able to make a start! JFW | T@lk 20:46, 16 November 2005 (UTC)

text: Check the page how: how's that look? – ClockworkSoul 19:30, 2 January 2006 (UTC)
thread_title:  Caffeine Chemistry 

message: I'm doing a biology project on drugged spiders' web patterns. This article has only one sentence about it and actually the resources are limited. I was just asking if you could add some more about that, or advice me a source, etc. Thanks for your time. --Quinlan Vos 19:58, 27 November 2005 (UTC)
replies: text: Will this message ever get attention? I really need some info from chem students. Thank you for your time again. --Quinlan Vos 01:46, 18 January 2006 (UTC)
thread_title:  A little bit help with spiders 

message: It seems to have an anti-caffeine agenda to me. Yes, technically it is a neutral fact, but IMO it is obviously meant to imply that caffeine has analogous adverse effects on the human mind. For this, it is actually a very weak argument, because a spiders nervous system is clearly very different from a humans (and they were probably given extremely high doses anyway). Yet, the picture seem quite convincing at first glance and some casual readers will probably consider it good "evidence" for the above-mentioned conclusion (people like analogies).
Thus, I find the picture highly misleading and vote for its removal (or maybe move it to a page about spiders or differences of drug effects between species, where it would be more on-topic than here). If you want to argue that caffeine has negative effects on human cognition, fine, but please do so explicitly and not in such an unfair way.
Sorry for the rant, maybe I'm overreacting. I guess that I'm just a little tired of this kind of "reasoning".
Comment: I agree that the picture should in no way be used as evidence for the argument that caffeine is highly dangerous and/or destructive. However, I think it is a rather interesting bit of information and should remain. I've seen two other similar pictures, where the spiders were on LSD and marijuana (not both at the same time). The LSD web was even more geometrically perfect than the average spider web, and the marijuana web was loosely constructed and unfinished. It would be foolish to speculate from these pictures that caffeine is destructive to thought and organizational thinking or that LSD enhances performance. Here is one of many links that has pictures of various drug-induced webs: http://www.trinity.edu/jdunn/spiderdrugs.htm
: There is no claim or insinuation that caffeine is highly dangerous, and considering that plant caffeine serves as an insect deterrant, the reason for its effect on arthropods is clear. The article makes no such claims about humans, however. – ClockworkSoul 15:12, 26 January 2006 (UTC)
replies: text:  There is one point about the spider drug testing.  Caffiene is actually more toxic than many of the other drugs tested (such as marijuana) in terms of the amount in mg per kg of bodyweight that needs to be consumed.  If we consider that the spiders used probably only weighed about 0.1g at best, then even the very small amounts of caffiene given to them are bound to be more toxic.  Mostly Zen 17:15, 10 May 2006 (UTC)
thread_title:  The spider web picture 

message: This is in response to this edit, with the comment "No caffeine, http://www.mrkland.com/fun/xocoatl/caffeine.htm". Your post prompted me to do a detailed search on the claim (I want everything to be accurate as possible), and I found the following results:
* The cited web page has a "science page", which cites "Biochemist, Apr/May 1993, p 15. copyright of Royal Society of Chemistry website 2000" as its source. However, no such journal as "Biochemist" exists. 
* I found a few journals with similar names, though: Biochemistry, Bioconjugate Chemistry, and Biomacromolecules. Searching the entire year of 1993 turns up two articles that mentioned caffeine in the article body, and none that mentioned both caffeine and chocolate.
* A quick PubMed search however, finds quite a number of articles that mention finding caffeine in both cocao and chocolate in the small quantities mentioned in the caffeine article.     
* Other sources confim this, including the International Cocoa Organization and the International Food Information Council.
ClockworkSoul 23:14, 3 January 2006 (UTC)
thread_title:  Re: "No caffeine, http://www.mrkland.com/fun/xocoatl/caffeine.htm" 

message: The article currently contains the following sentence:
"In addition, Arabica coffee, which is widely regarded as the highest quality of commercially produced coffee, contains less caffeine content than the Robusta variety, which is normally used in instant coffee or is combined with arabica to produce a flavorful yet highly energizing coffee drink"
It seems to claim special "energizing" qualities for a drink made from both arabica and robusta. This sounds rather like quack science. I can think of two possibilities:
1) the article previously contained a brand name of some energy drink containing both types of coffee bean, and that the brand name has been removed to leave a rather misleading sentence.
or
2) someone genuinely believes that a mixture of the two coffees has this special property... for which there seems to be no evidence whatsoever.
Either way, I think the phrase "yet highly energizing" has got to go.
I'll wait for a second opinion before going ahead, but if anyone else agrees please go ahead and make the change.
* I'm with you. At the very least, it's POV.  I'm removing it now. – ClockworkSoul 22:25, 21 January 2006 (UTC)
thread_title:  Claim about an "energizing drink" 

message: Comment about a paragraph that perhaps needs correction: It is my understanding that one of the reasons that determines which source of caffeine is used (natural -extracted- or artificial -synthesized-) is the respective country regulations, i.e., whether they require to use only natural products in the drinks. Some manufacturers of soft drinks used to obtain "forensic" carbon isotope analysis on batches of caffeine in order to decide whether to use them in their drinks. Jclerman 17:22, 28 January 2006 (UTC)
thread_title: "The caffeine is generally obtained..."

message: Can someone go over to cocoa and write about its chemical composition? it seems the caffeine article has more information on it that its own article. --Fs 11:31, 17 March 2006 (UTC)
thread_title:  the cocoa article 

message: Report by China Central TV
It seemed that in some places in Shanxi, China, people are abusing caffeine in a way not dissimliar to heroin; they even "chase the dragon" and there are illegal labs synthesizing caffeine from theophylline since the former is a controled substance in China yet the latter isn't.
Should it be added to this article? —The preceding unsigned comment was added by Samuel Curtis (talk • contribs) .
* The article is unavailable now, but I'm personally skeptical of articles posted on any tightly-controlled state-operated media, especially when it has do do with a substance that is banned. This smells of propaganda to me, and I would prefer that we wait for a less potentially biased source. – ClockworkSoul 20:51, 19 March 2006 (UTC)
thread_title:  A Strange report of Caffeine Addiction 

message: Guaranine is not any more the mixture that it was for von Martius. For the ChemId Plus, PubChem, and ACS (CAS numbers) databases it is a synonym of caffeine. Same structural formula. When searching in ChemId Plus,  (either Lite or Advanced) look for all names and synonyms. Enter guaranine in the search boxes of the databases linked below and read the findings, the formulas, the code numbers, the references, etc. Similarly, you'll also find that a synonym of caffeine is mateine, which still is believed by many to be different from caffeine. There is no doubt. Since the structural formulas are identical the pure substances are identical. In the respective plants they might bind with different compounds, that's why coffee and tea and mate and guarana drinks are different. But the pure crystaline substances are identical. For an ethnobotanical overview based on von Martius findings and their sequel see the Raintree Tropical Plant Dabase: Guaraná. Another ethnobotanical database is "Dr. Duke's".
The links below take you to the URLs where to initiate searches. 
Just enter guaranine or any other drug name in the search boxes.
*PubChem
*ChemIDplus Lite
*ChemIDplus Advanced
*TOXNET
Jclerman 00:58, 24 March 2006 (UTC)
thread_title:  Databases to verify : guaranine = caffeine 

message: The description on how caffeine works becomes misleading when it states "The result is an increase in the levels of epinephrine or adrenaline and norepinephrine released via the hypothalamic-pituitary-adrenal axis[4]". As far as I understand it, adrenaline is released from the adrenal medulla under stimulation by the sympathetic nervous system. The hypothalamic-pituitary-adrenal axis is involved in the release of corticosteroid hormones such as cortisol, NOT adrenaline. (Castewart 10:17, 14 April 2006 (UTC)
thread_title:  Mechanism of action 

message: Just reviewed this nomination.  This is a very nice article and it seems pretty comprehensive.  The popular culture aspects are covered as well as the metabolism and science.  I think my main criticism would be that the refs really need cleaning up and converting to inline refs. Walkerma 04:06, 19 April 2006 (UTC)
thread_title:  Good article promotion 

message: Citations were a mixture of inline links () and footnote references (<ref>; see WP:FN). I just converted to all footnote refs because it seems to be the Funky New Method in wikipedia. However, now I'm not sure the change is desired: most were of the inline format, and formatting is often just a matter of personal preference (so stick with the initial choice unless compelling reason or consensus). So anyone feel free to revert or to complain and I'll revert and fix the stragglers to inlines. DMacks 18:30, 24 May 2006 (UTC)
thread_title:  Reference formatting 

message: I noticed methyltheobromine listed as an alternate name.  This struck me as an odd name, as the molecule obviously lacks a Bromine.  Is this right? Tyro 09:44, 2 June 2006 (UTC)
replies: text: Yup. Check the second sentence of theobromine to learn the origin of its name. DMacks 15:42, 2 June 2006 (UTC)
replies: text:  Interesting, thanks! Tyro 04:34, 7 June 2006 (UTC)
thread_title: Other name: methyltheobromine

message: What is the purpose/properties of putting/allowing caffeine in soft drinks and other beverages (assuming we're not talking about an Energy Drink or something else promoted as a stimulant)? Does decaffeined soda taste different than its counterpart? What is the justification for not having more decaffeinated beverages?
:a reason may be flavor. caffeine is very bitter - if you would produce coca-cola without caffeine, it would taste totally different. (unless you would find an alternative bitter flavoring)
:also i think many drinks are consumed because of their caffeine content. cola is often consumed because of the effects of caffeine in it. consumers probably wish to have a caffeinated drink that has less caffeine then a energy drink like red bull etc.
:81.221.211.102 23:51, 2 July 2006 (UTC)
thread_title:  Purpose 

message: ...which are incomprehensible to those used to metric units especially when they're used with SI derivative units. I'd propose some unit cleaning & internationalizing for the article, eg. I have no idea what the following means: ~2 shots of espresso from robusta beans (2 floz) (what is floz? what is a shot in this context?)....Remember that the readers are a global crowd. 
:"Floz " is a typo for "fl oz," or "fluid ounce." A British fluid ounce is 28.413 ml (found on http://convert.french-property.co.uk/); American fluid ounces are very slightly different, but I think they are also approximately 28.4 ml.140.247.131.116 20:31, 4 January 2006 (UTC)
replies: text: I don't think the article is anti-coffee; I was actually surprised because I'd read a previous version that was. I hope any positive effects of caffeine have ended up - or will end up - in the article. But it's important to differentiate between the reported or purported health benefits of caffeine and those of coffee and tea. Anchoress 20:45, 20 August 2006 (UTC)
thread_title:  Why the imperial units and anti-coffee bias? 

message: What is USP, mentioned in the image text? United States Pharmacopoeia?
:yes probably is - it might be a good idea to change this to "pure caffeine" because that is probably what it its. (this would be especially good for readers outside of the US) 81.221.211.102 23:53, 2 July 2006 (UTC)
replies: text: What does "pure" mean? DMacks 02:54, 6 July 2006 (UTC)
replies: text: "USP" indeed is an abbreviation for United States Pharmacopoeia (and is the only relevant-sounding meaning in the USP page). In the context of the image text, it is an indicator of the grade (purity and types/amounts of various impurities) of the material. To quote the Pharmacopoeia page, "the initials USP are affixed to materials' names to indicate that they conform to the specifications in the USP". DMacks 03:00, 6 July 2006 (UTC)
thread_title:  USP? 

message: I don't have a chance to look over it in detail at the moment, but some of the grammer seems awkward if not wrong.
While relatively safe for humans, caffeine is considerably more toxic to some other animals such as dogs, horses and parrots due to a much poorer ability to metabolize this compound. Caffeine has a much more significant effect on spiders, for example, than most other drugs do. 
While I am not compleatly sure if that is wrong, it just sounds akward. I was thinking of changing it to
While relatively safe for humans, caffeine is considerably more toxic to some other animals such as dogs, horses and parrots due to a lesser ability to metabolize this compound. Caffeine has a greater effect on spiders, for example, than most other drugs do.
I'll look over this article when I have time tonight to seem if theres any other examples.
CBush98 20:41, 11 July 2006 (UTC)
replies: text: Perhaps you mean spelling, semantics, syntax, and/or grammar? --69.9.27.14 20:47, 11 July 2006 (UTC)
thread_title:  Grammer 

message: From ChemId @ the NLM full database. You can find the reference in a section of the article guarana with direccions of how to use it.
The synonyms are: mateina (original Spanish) - mateine (English translation, as Cafeina-Caffeine, Purina-Purine, Teina-Teine, etc). Since the putative substance was first "described" by Spanish speakers, ChemId uses "mateina", but there is a huge amount of references centered on whether mateine is or is not caffeine. All English references spell it "mateine". See, among others :
Name of Substance
 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
 Caffeine
 Caffeine [BAN:JAN]
Synonyms
 1,3,7-Trimethyl-2,6-dioxopurine
 1,3,7-Trimethylxanthine
 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
 5-26-13-00558 (Beilstein Handbook Reference)
 AI3-20154
 Alert-pep
 Anhydrous caffeine
 BRN 0017705
 CCRIS 1314
 Cafamil
 Cafecon
 Cafeina
 Caffedrine
 Caffein
 Caffeina [Italian]
 Caffeine
 Caffeine (natural)
 Caffeine, anhydrous
 Caffeine, synthetic
 Caffine
 Cafipel
 Coffein [German]
 Coffeine
 Coffeinum
 Dexitac
 EINECS 200-362-1
 Eldiatric C
 FEMA No. 2224
 Guaranine
 HSDB 36
 Kofein [Czech]
 Koffein
 Koffein [German]
 Mateina
 Methyltheobromide
 Methyltheobromine
 Methylxanthine theophylline
 NCI-C02733
 NO-Doz
 NSC 5036
 Nix Nap
 Nodaca
 Organex
 Quick-Pep
 Refresh'N
 Stim
 Thein
 Theine
 Theobromine, 1-methyl-
 Theophylline, 7-methyl
 Tirend
 Vivarin
 Xanthine, 1,3,7-trimethyl
Systematic Name
 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
 Caffeine
Superlist Name
 Caffeine
Jclerman, can you find a reference that uses the English translation? I can find no such reference in any of the usual chem sources PubMed doesn't even list a single instance of either meteine or mateina (go figure!), and all Google turns up is a MiracleBurn advertisement. – ClockworkSoul 15:34, 16 August 2006 (UTC)
replies: text: Wrong Google. Use Google Scholar . Jclerman 15:43, 16 August 2006 (UTC)
replies: text:  Google scholar returns only 4 English references, still mostly advertisements. I'll still accept the translation, of course. – ClockworkSoul 15:44, 16 August 2006 (UTC)

text: You are correct. See the one reference that seems to be OK . I've been fighting the "advertisers" of mateine as a diff subst from caffeine since 10 yrs ago. However, there is somewhere a reference, in Spanish if I remember well, claiming that there is a species of I. paraguayensis that contains less or none (?) of the stimulant.
Jclerman 15:54, 16 August 2006 (UTC)
thread_title:  synonyms 

message: Here are two less scholarly references than the last one referenced above. The two new ones are:  and .
* You can always rely on Erowid. I've found more excellently references material there than nearly anywhere else. – ClockworkSoul 17:59, 16 August 2006 (UTC)
thread_title: translation

message: I re-did the auto review incase anything has changed. Strike out the sections as they are verified or finished. The following suggestions were generated by a semi-automatic javascript program, and may or may not be accurate for the article in question.
*Per WP:CONTEXT and WP:MOSDATE, months and days of the week generally should not be linked. Years, decades, and centuries can be linked if they provide context for the article. All of these come from the cite templates.
*Per WP:MOS, avoid using words/phrases that indicate time periods relative to the current day.  See footnote
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*Please alphabetize the interlanguage links.See footnote
*There are a few occurrences of weasel words in this article- please observe WP:AWT. Certain phrases should specify exactly who supports, considers, believes, etc., such a view.  See footnote 
*Watch for redundancies that make the article too wordy instead of being crisp and concise. (You may wish to try Tony1's redundancy exercises.)
**Vague terms of size often are unnecessary and redundant -  “some”, “a variety/number/majority of”, “several”, “a few”, “many”, “any”, and “all”. For example, “All pigs are pink, so we thought of a number of ways to turn them green.”
*As done in WP:FOOTNOTE, footnotes usually are located right after a punctuation mark (as recommended by the CMS, but not mandatory), such that there is no space inbetween. For example, the sun is larger than the moon [2]. is usually written as the sun is larger than the moon.[2]
*Please ensure that the article has gone through a thorough copyediting so that the it exemplifies some of Wikipedia's best work. See also User:Tony1/How to satisfy Criterion 2a. See footnote
You may wish to browse through User:AndyZ/Suggestions for further ideas. Ravedave 04:08, 20 August 2006 (UTC)
thread_title:  Automate review 

message: *See if possible if there is a free use image that can go on the top right corner of this article.See footnote 
*Per WP:MOSNUM, when doing conversions, please use standard abbreviations: for example, miles -> mi, kilometers squared -> km2, and pounds -> lb.
*Per WP:MOSNUM, please spell out source units of measurements in text; for example, "the Moon is 380,000 kilometres (240,000 mi) from Earth.See footnote
*Per WP:CONTEXT and WP:BTW, years with full dates should be linked; for example, link January 15, 2006, but do not link January 2006.See footnote I am not sure why this si still showing up. I searched for all months and 19 and 200 and came across no stray dates. 
*Watch for redundancies that make the article too wordy instead of being crisp and concise. (You may wish to try Tony1's redundancy exercises.)
**Vague terms of size often are unnecessary and redundant -  “some”, “a variety/number/majority of”, “several”, “a few”, “many”, “any”, and “all”. For example, “All pigs are pink, so we thought of a number of ways to turn them green.”
*Please ensure that the article has gone through a thorough copyediting so that the it exemplifies some of Wikipedia's best work. See also User:Tony1/How to satisfy Criterion 2a. See footnote
You may wish to browse through User:AndyZ/Suggestions for further ideas. Thanks, Ravedave 05:03, 21 August 2006 (UTC)
thread_title: Re-auto-review

message: So far it's very interesting and well-written. Needs a tiny bit of copyediting, notably some punctuation after citations.
: After citations? WP:FOOTNOTE recommends that footnotes be placed immediately after a punctuation mark... – ClockworkSoul 06:50, 20 August 2006 (UTC)
replies: text: Yeah, that's what I mean. There are some instances of the punct after the citations, those need to be fixed. You'll notice about three in the lead paragraph. I don't mind doing them, but I have to be in a particular frame of mind. :-) Anchoress 06:52, 20 August 2006 (UTC)
thread_title: Citations

message: The following statement concerns me, and because the source isn't online I can't check it:
:A Study in the British Journal of Addiction concluded that caffeinism, although infrequently diagnosed, may afflict as many as one person in ten in the general population.
What general population? The world population? The western world? North America? 
:: The exact quote from the paper reads "Although infrequently diagnosed, caffeinism is thought to afflict as many as one person in ten of the population." I added the "general", perhaps as a misguided attempt at clarification. I'll remove to restore the original wording, but I'll have to get the article from my University's paper holdings to get complete context. – ClockworkSoul 06:50, 20 August 2006 (UTC)
replies: text: Hmmm, yeah... that really does concern me - it's waaaay too bad that the original paper is so vague. Maybe you can find another citation with more clarification? Anchoress 06:57, 20 August 2006 (UTC)
thread_title: Citation for caffeinism in the general population

message: This paragraph (at the beginning of 'metabolism' needs to be reworded IMO:
:Caffeine is completely absorbed by the stomach and small intestine within 45 minutes of ingestion. After ingestion, It is widely distributed in total body water and is eliminated by apparent first-order kinetics.
I understand it, but it's awkward. Is 'total body water' a technical term? :-) And why is it 'apparent' first order kinetics? What makes it 'apparent'? 
:: A carryover from a previous version that I failed to catch... I went and tidied it up and reflexively added a reference. – ClockworkSoul 06:50, 20 August 2006 (UTC)
replies: text: Yeah, it's way better. Anchoress 06:57, 20 August 2006 (UTC)
thread_title: 
Reword paragraph at beginning of 'Metabolism'


message: Re: the fact tags; one of them is for the 'added caffeine' claim for pop. I'm almost certain (I can find info if you need it) that in my country, Canada, soda makers are not allowed to add extra caffeine, they can only allow the inclusion of whatever occurs naturally in the flavourings. That's apparently one of the things about the new energy drink craze; there are drinks that contain natural levels of caffeine like 10 times that of pop (I don't need to tell you that, you already know), but since it's natural, it's legal.
: That reference would be very helpful! – ClockworkSoul 06:50, 20 August 2006 (UTC)
replies: text: OK I misremembered the info about Canadian soft drink rules. Here's a link to an article about the topic, which clarifies that it is only clear soft drinks that are covered by this rule. Interesting article tho. Anchoress 06:46, 20 August 2006 (UTC)
thread_title: Fact tags

message: Also, overall: Excellent. I read it a week or so ago and I hated it; it's soooo much better now. Nice to get the drama and scaremongering out of it.
I'll be back to do another read-through. Anchoress 06:30, 20 August 2006 (UTC)
replies: text: I happened across this article a week or two ago and thought it deserved to be made FA. But I see there are already people working hard on it. I'll try tonight to do a manual review of the article. Good job guys! (and when you're done wanna help on Minnesota? :) ) -Ravedave 18:12, 20 August 2006 (UTC)
replies: text:  Maybe I will... but I'm already pretty beat. :) Making something like caffeine into a FA is practically a full time job! – ClockworkSoul 18:39, 20 August 2006 (UTC)

text: Don't give me any compliments, it seems to be all ClockworkSoul. I'm just pitching for the final inning. Anchoress 19:31, 20 August 2006 (UTC)
replies: text:  I took an hour and a half and read the whole article and copy edited as I went. Here is the diff (some of outriggrs changes got in there too) . If you step through and look at my edit comments it should be very clear. No ownership so feel free to revert any changes that you want. -Ravedave 05:07, 21 August 2006 (UTC)
replies: text: They all seem good to me (except one typo, which I fixed). Thanks! Hopefully tonight, when I get home, I'll be able to rewrite that one section about caffeine extration. – ClockworkSoul 15:59, 21 August 2006 (UTC)
thread_title: Overall comments

message: I just completed archiving the old talk from this page (my first archive, YAY!). I removed undated discussions and those whose last entries were before January 2006. I did my best to keep them in order although one or two may be a teensy bit out of order (difficult to tell because most of them are undated). If I moved anything in error my apologies and if there's anything that anyone thinks should be back in the main talk page feel free to move it back. Anchoress 20:36, 20 August 2006 (UTC)
replies: text: Excellent, thanks! The page certainly needed it. – ClockworkSoul 20:13, 21 August 2006 (UTC)
replies: text: The talkpage is still very long; I'd planned to do another archive after the FA (which I was confident would make it, congrats again!). So I'll do that now. Anchoress 06:38, 5 September 2006 (UTC)
thread_title:  [[Talk:Caffeine/Archive01|Caffeine talk archive]]