Talk:Endothelial progenitor cell

message: I propose endothelial stem cell be merged into endothelial progenitor cell.
Endothelial stem cell is a term that has been used infrequently in literature (strict PubMed search returns <20 results), and in most cases refers to cells that would be better characterized as progenitor cells. 
* http://www.ncbi.nlm.nih.gov/pubmed/?term=%22endothelial+stem+cell%22
On the current ESC page, the majority of citations either talk about developmental cells (angioblasts), highly proliferative EPCs (endothelial colony forming cells or other putative progenitors), or are very far out of date. One citation specifically refers to "stem-like" progenitors, and the other uses the term ESC to refer to the angioblast.
* Lucchinetti E, Zeisberger SM, Baruscotti I, Wacker J, Feng J, Dubey R, Zisch AH, Zaugg M. (2009). "Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevofluorane exposure: preconditioning of angiogenic cells by volatile anesthetics". Anesthesia Analgesia 109 (4): 1117–26. doi:10.1213/ane.0b013e3181b5a277.
* Kubo H, Alitalo K. (2003). "The bloody fate of endothelial stem cells". Genes and Developmental 17: 322–329. doi:10.1101/gad.1071203
Stem cells are not only defined by their proliferative ability, but by potency; the ability to differentiate into multiple cell types. ESCs as defined on the current wikipedia page do not fit this model.
The text on the page in future efforts already uses the term EPCs, and some sections (sources, role in development of the vascular system, role in cancer) don't mention the ESC at all. I don't believe the ESC is a well enough established or proven concept to have its own page, and believe the information would be better added to endothelial progenitor cell, with some perhaps also moved to hemangioblast or angioblast.
Even the most recent papers regarding so called vascular ESCs refer to them as a subset of highly proliferative ECFCs, which are better classified as progenitors due to unipotency.
* http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001407
Thanks for reading.  — Preceding unsigned comment added by DavidOSX (talk • contribs) 17:49, 12 May 2015 (UTC)
replies: text: Closing, given the lack of support over more than 2 year, and the presenence of opposition. Will link with a hatnote to maintain the link between the pages. Klbrain (talk) 21:44, 16 October 2017 (UTC)
thread_title:  Merger proposal 

message: I'm going to update this page significantly in the coming months, starting late Nov/early Dec 2007. Please see the Feb 2007 article in the journal Blood by Yoder and colleagues, and the review in Leukemia by Prater. "EPC" now signifies a very generic term, and is probably not specific enough to cover the many purported EPCs that exist in the literature.Danprater (talk) 19:59, 21 November 2007 (UTC)
thread_title:  initial announcement 

message: I'm writing a report on the application of EPCs for biomedical applications. For background, lining synthetic materials (stents, VADs, tissue engineering scaffolds)  with EPCs may induce formation of an endothelial layer that protects against thrombosis or restenosis.  Here are two reviews if anyone's interested. 
1. Avci-Adali M, Paul A, Ziemer G, Wendel HP. New strategies for in vivo tissue engineering by mimicry of homing factors for self-endothelialisation of blood contacting materials. Biomaterials. 2008;29(29):3936-45. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18640715.
2. Avci-Adali M, Ziemer G, Wendel HP. Induction of EPC homing on biofunctionalized vascular grafts for rapid in vivo self-endothelialization--a review of current strategies. Biotechnology advances. 2010;28(1):119-29. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19879347.  —Preceding unsigned comment added by Ahaque89 (talk • contribs) 15:56, 3 April 2010 (UTC)
thread_title:  Surface coating biomaterials with EPCs 

message: Before any reinsertion, I think the following text needs attention to its issue of being contradictory to later papers that seem to justify the idea of this cell type very well. At least it should mention on what grounds the concept would be questionable:
Recent discoveries in both mice and humans have led scientists and researchers to question the existence of endothelial progenitor cells.
Mikael Häggström (talk) 15:15, 19 August 2011 (UTC)
thread_title:  Papers questioning their existence