Talk:Wnt signaling pathway

message: Signaling or signalling? I believe that "signaling" is the more universally accepted spelling. Mr.Bip 20:45, 29 July 2005 (UTC)
replies: text: Signalling is British spelling, Signaling is American spelling. Neither is more "universal" - it depends entirely on the Journal you are publishing in and the consensus reached by Wikipedians for a particular article. Biochemza, 22:16, 25 November 2007 (UTC)
thread_title:  Title spelling 

message: Wnt signaling occurs by diffents pathways, but only the canonical pathway seems to be illustrated here. What about que non-canonical pathways such as PCP and Ca2+?
I have a textbook that says that disheveld's involvement is unknown and GSK3 and CK1 phosphorylate lrp to recruit axin to the membrane for the complex inactivation. is that right?  —Preceding unsigned comment added by Greeny12m (talk • contribs) 11:47, 26 April 2009 (UTC)
replies: text: Dishevelled and Wnt signaling: is the nucleus the final frontier? seems to indicate that some  knowledge is there "Yet, when the basic conclusion of a nuclear localization and function of Dsh is accepted, several questions remain. If Dsh function is required in the nucleus for canonical Wnt signaling, why is no hyperactivation of the pathway observed by targeting Dsh to the nucleus?" Rich Farmbrough, 14:55, 18 May 2011 (UTC)

text: In the long term - and especially from a researcher's point of view - I suspect this is likely to be true. But WP needs to reflect that language that is used in the field by experts at the current time. Biolprof (talk) 16:36, 4 September 2013 (UTC)
thread_title:  Wnt pathways 

message: First name added based on http://www.bio.pku.edu.cn/userfiles/File/lifm//Roeland%20nusse/_CVNussesept2008short.pdf
-- Jo3sampl (talk) 01:05, 16 June 2011 (UTC)
thread_title:  Nusse, Roeland 

message: I'm not an expert here, but I saw this MIT lecture by Ed Scolnick: http://mitworld.mit.edu/video/687 In it, he claims this bio-chemical pathway (the Wnt signaling pathway) is emerging as important in the pathogenesis of psychiatric illness. It's where lithium is known to work, and three genes found in association with mental illness are related to different steps in the pathway. There seems to be no mention of psychiatry or mental illness currently in the article so I wanted to point it out for those working on the article. —Pengo 02:38, 30 August 2011 (UTC)
thread_title:  Schizophrenia 

message: The study is neither recent (2007) nor is the reference to the actual peer journal article but instead to the press release. I will change this so it is more objective unless someone has other opinions? Jazzvibes (talk) 02:54, 18 April 2012 (UTC)
thread_title:  Advertising/Not relevant reference to Stanford school of medicine 

message: The different pathways,canonical and non-canonical, would be better understood if they were both under the mechanism section of this article.  Both pathways are mechanisms and placing them in the same section would allow for a better cross comparison of the two.
Also, for the genes and proteins under the members section, it might be useful to give a brief description alongside each in order to guide users to more specific information.  I hope these are useful suggestions. Gpruett2 (talk) 02:41, 4 February 2013 (UTC)
replies: text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Added citation Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing checking Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Feel free to do so Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Reworded with additions Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Added a lovely table with multiple species.  Add to it if you wish Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * I'm going to incorporate this under mechanism at a later time Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Added some lovely images Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Thanks for the suggestions and good luck to you as well Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * I added more figures.  Do they solve this issue? Gpruett2 (talk) 05:17, 16 April 2013 (UTC)
thread_title: Organization/Additional Information

message: These comments are intended for Gpruett2 as part of our course assignment.
First of all: excellent job with the writing of your new sections. You have successfully conveyed some very dense information into a format appropriate for this encyclopedia, which is no mean feat! Now, onto the suggestions: most of them are for sections that you didn't write, which naturally need a bit more work. I've tried to keep them in the order of the article layout and include the relevant section name, but there may be some mistakes and omissions.
====Minor edit suggestions====
* Make the Wnt/WNT name consistent throughout the article, and italicize gene names (see last bullet point in this section).
:* Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)
replies: text: * Added citation Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing checking Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Feel free to do so Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Reworded with additions Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Added a lovely table with multiple species.  Add to it if you wish Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * I'm going to incorporate this under mechanism at a later time Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Added some lovely images Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Thanks for the suggestions and good luck to you as well Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * I added more figures.  Do they solve this issue? Gpruett2 (talk) 05:17, 16 April 2013 (UTC)
thread_title:  Comments from Jnims 

message: * Make the Wnt/WNT name consistent throughout the article, and italicize gene names (see last bullet point in this section).
:* Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)
replies: text: * Added citation Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Done Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing checking Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:12, 16 April 2013 (UTC)

text: * Feel free to do so Gpruett2 (talk) 05:12, 16 April 2013 (UTC)
thread_title: Minor edit suggestions

message: * The "Discovery" section is hard to follow. The information about MMTV and murine breast cancer and its relationship to wingless is presented in a somewhat disjointed fashion, and I found myself having to read the first paragraph multiple times to keep everything straight. Does Wnt have characteristics of both Wg and Int, since it's a portmanteau of the two words? Also, is it necessary to mention the names of the scientists who discovered the various Wnt players? (I know you didn't write the section originally, but those are some things to consider.)
:* Reworded with additions Gpruett2 (talk) 05:14, 16 April 2013 (UTC)
replies: text: * Added a lovely table with multiple species.  Add to it if you wish Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * I'm going to incorporate this under mechanism at a later time Gpruett2 (talk) 05:14, 16 April 2013 (UTC)

text: * Added some lovely images Gpruett2 (talk) 05:14, 16 April 2013 (UTC)
thread_title: Bigger edit suggestions

message: * Citations 1 and 7 are the same article (but cited slightly differently, hence their going undetected).
:* Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)
replies: text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Ongoing Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Fixed Gpruett2 (talk) 05:15, 16 April 2013 (UTC)

text: * Thanks for the suggestions and good luck to you as well Gpruett2 (talk) 05:15, 16 April 2013 (UTC)
thread_title: Citation edits

message: *Consider moving the figure at the top down to the"Foundations of Wnt signaling section"
*I agree with Julia that the article seems text heavy, but if you can make the first figure much larger, you may not need more figures.
Biolprof (talk) 02:02, 14 April 2013 (UTC)
replies: text: * I added more figures.  Do they solve this issue? Gpruett2 (talk) 05:17, 16 April 2013 (UTC)
thread_title: comments from Biolprof

message: *Looks really good, super informative
:* Thanks.
*Could be a little more concise in the history section. I'm not sure if you should but there are a lot of thus and therefore type of words that could just be deleted 
:* I have deleted the words you suggested if they were not necessary.  I also removed some unnecessary sentences from the History section and left everything that I believe is necessary.
*Good images, makes the text easier to understand 
:* Thanks.
BreCaitlin (talk) 21:20, 29 April 2013 (UTC)
replies: text: * Thank you for your suggestions.  I hope you continue to enjoy the article. Gpruett2 (talk) 20:50, 7 May 2013 (UTC)
thread_title:  Peer Review: BreCaitlin 

message: *The figure at the beginning of the article next to the leading section seems a bit out of place. Perhaps you should move it down to the section that talks about the pathways?
:*I deleted this figure since it was a repeat of the other figures.
*Went through and made minor grammar/spelling changes.
:* Thanks!
*As stated before, the article seems very text heavy and dense. I think that the figures you use in describing the Wnt Pathway are insightful, but they seem too close together and make the section way too busy. I'm not crazy about the "tunneling" of text between your images. Having pictures on both the left, right, top, and bottom is really overwhelming. Is it at all possible to move this or try and space it out a little without destroying the message you're trying to make?
:* I removed the tunneling and made them staggered.  I hope you find it less overwhelming and still informative.
*I'm not sure the prose fits "encyclopedic" status. For example, you use a lot of: thus, consequently, aforementioned, etc. I went through and tried to delete the ones I thought were the most obvious, but you could double check and polish that up a bit.
:* Thank you for the prose edits.
*The section "neural tube patterning" seems a bit lengthy. I would suggest breaking this down into a couple subcategories, such as "early neuronal development," "transcription factors and their effects," and "bone morphogenetic proteins" or something like that.
:* This section has been removed and integrated into the section Axis patterning.
*I have the same criticism for the Stem cell differentiation section. Try and break it up into a couple more subcategories. Less is more!
:* This section has been removed and integrated into the section Cell fate specification.
*I noticed you have a section for Type II Diabetes but don't have anything under it. If you're going to add information, that's great! But if not, I would delete that heading until a contribution is made.
:* I will be adding this information promptly.
*Very impressive contribution. You did a great job! MChapman5 (talk) 05:28, 30 April 2013 (UTC)
replies: text: * Thank you for your lovely comments. Gpruett2 (talk) 20:47, 7 May 2013 (UTC)
thread_title:  Peer Review comments from MChapman5 

message: *Nice vocabulary with the portmanteau.
** Thanks
*Easy to read introduction and discovery sections.
** Thanks
*I feel that the first paragraph under the “canonical and noncanonical pathways” was a little wordy and could be cut down.
** Done
*Excellent pictures, an inspiration for the ones that I made.
** Thanks
*I am unsure of the reason for making some words bolded, but I am sure there was a method to this.
** I removed unnecessary bolding, but left pathway names bolded.  Specifically, I bolded Wnt signaling pathway, canonical Wnt pathway, noncanonical planar cell polarity pathway, and noncanonical Wnt/calcium pathway.
*Having more than just two sources to describe the three major Wnt pathways may be nice. I am sure there is a lot of literature that describes the pathways and it shouldn’t be hard to find more sources.
** Added more sources
*There is a lot going on in the “Other pathways” as well as the “regulation” sections. Maybe having more sources here could be good.
** Added more sources
*Perhaps introductory paragraphs under the “Wnt-induced cell responses” and “clinical implications” could be good.
*I was a little unsure as to how reactive oxygen species tied in with diabetes, but that might be my fault.
** Added further source-backed clarification
*I enjoyed the clarity of the entire piece.
** Thanks
Flemingrjf (talk) 03:41, 8 May 2013 (UTC)
thread_title: Flemingrjf Comments

message: *Do you think you should include what cells are releasing Wnt proteins?
** I could not find specific cells that produce Wnt, which may mean that any cell can.  I don't want to list this unless I can find a source.  Any suggestions?
*With all the domains in the proteins, I find it a little distracting that you include all the proteins that they stand for, e.g. DIX and auxin, which isn't even related to Wnt.
** Removed all the protein names.
*I think you should define canonical and non-canonical before you bring up the three types.
** I think it is more important to establish why those terms are associated with Wnt signaling first and then define them, as it currently is in the paragraph under Canonical and noncanonical pathways.
*does casein kinase have a wikipedia page?
** Added a wiki link
*Other pathways is not justified to the left because of the picture. 
** Fixed
*Par6 and LGI don't have links
** Done
*How does palmitoylation enhance secretion? wouldn't it cause it to get stuck in the membrane?
** Explained
*You describe just a few functions of Wnt but don't even name any others.
** I describe the basic overarching embryonic function categories and the specific functions are listed within those sections.  If you think it would be better to list the extensive functions of Wnt, which would be very long, let me know.  I condensed them into those paragraphs for the sake of brevity.
*could you be more descriptive as to how it mediates insulin resistance. You talk about insulin pathways which is going to be distinct from Wnt.
** Insulin resistance is discussed under the type II diabetes section.
*You don't talk about cyclins, I feel like those are really important in cancer biology.
** I believe that cyclins has its own page where it can talk about cancer biology, so there is no point in describing its specifics in this article.  I did, however, mention it under cell proliferation
*link out to ROS
** Added
*It seems like a stretch that DNA or protein damage causes problems with insulin sensitivity specifically, was there any other evidence for this link or is it just speculation?
** Added further clarification
Altogether really great work Maximus155 (talk) 17:34, 8 May 2013 (UTC)
thread_title: Peer review by Maximus155

message: Hello again! Thanks for taking my previous suggestions, I hope you found them helpful. Let's start with the things I particularly enjoyed/appreciated:
====Good stuff====
*Lots of informative content
*Good organization
*Clear prose
*Lovely table of proteins
*Excellent images
** Thanks
And here are some suggestions for improvement:
====Suggested improvments====
General: You can remove "has been shown to" in all of its instances, for the sake of brevity. Instead, just say "Wnt is involved in [such and such]."
* Done
Intro
*Consider changing the word "classification" in this sentence to something like "variety" or "type:" "The Wnt signaling pathways are a classification of biological signal transduction pathways that regulate embryonic development and other key biological processes."
** Fixed
*Rewording suggestion: "This pathway is clinically important since mutations in its components can lead to a variety of cancers and diseases such as breast cancer, prostate cancer, glioblastoma, type II diabetes, and several others.
**Suggestion: "The clinical importance of this pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes, and others."
*** Added your suggestion
Discovery
*Although the background about proto-oncogenes is interesting and would be an excellent addition to a paper, I am not sure it fits the encyclopedic framework. In the interest of brevity, perhaps you should merely discuss the direct discovery of Wnt signaling.
** I do not agree.  I believe this section is an appropriate length and that mentioning the discovery of proto-oncogenes, which encouraged the discovery of Int1, is important.
*Make sure all gene (and genus) names are italicized
** Done
*This sentence is a little clunky: "The uncovering of this shared homology was an exciting discovery due to the fact that previous research by Christiane Nüsslein-Volhard and Eric Wieschaus, who would later win the 1995 Nobel Prize in Physiology or Medicine for that research, had already elucidated the function of Wg as a segment polarity gene involved in embryonic development."
** Fixed
Mechanism (especially anything below Canonical and noncanonical pathways)
*This section could use one or two more sources, since much of the information seems to come from #4 (and #8, earlier).
** Added
Wnt-induced cell responses
*This section, especially the first few paragraphs/subsections, could use one or two more sources, since much of the information seems to come from #13.
** Added
*This sentence could be reworded for brevity: "The effect that Wnt signaling has on insulin activity is that it increases a cell's sensitivity to insulin"
**Suggestion: "Wnt signaling increases a cell's sensitivity to insulin."
*** Changed
Best of luck! Jnims (talk) 19:53, 8 May 2013 (UTC)
thread_title:  More comments from Jnims (to Gpruett2) 

message: General: You can remove "has been shown to" in all of its instances, for the sake of brevity. Instead, just say "Wnt is involved in [such and such]."
* Done
Intro
*Consider changing the word "classification" in this sentence to something like "variety" or "type:" "The Wnt signaling pathways are a classification of biological signal transduction pathways that regulate embryonic development and other key biological processes."
** Fixed
*Rewording suggestion: "This pathway is clinically important since mutations in its components can lead to a variety of cancers and diseases such as breast cancer, prostate cancer, glioblastoma, type II diabetes, and several others.
**Suggestion: "The clinical importance of this pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes, and others."
*** Added your suggestion
Discovery
*Although the background about proto-oncogenes is interesting and would be an excellent addition to a paper, I am not sure it fits the encyclopedic framework. In the interest of brevity, perhaps you should merely discuss the direct discovery of Wnt signaling.
** I do not agree.  I believe this section is an appropriate length and that mentioning the discovery of proto-oncogenes, which encouraged the discovery of Int1, is important.
*Make sure all gene (and genus) names are italicized
** Done
*This sentence is a little clunky: "The uncovering of this shared homology was an exciting discovery due to the fact that previous research by Christiane Nüsslein-Volhard and Eric Wieschaus, who would later win the 1995 Nobel Prize in Physiology or Medicine for that research, had already elucidated the function of Wg as a segment polarity gene involved in embryonic development."
** Fixed
Mechanism (especially anything below Canonical and noncanonical pathways)
*This section could use one or two more sources, since much of the information seems to come from #4 (and #8, earlier).
** Added
Wnt-induced cell responses
*This section, especially the first few paragraphs/subsections, could use one or two more sources, since much of the information seems to come from #13.
** Added
*This sentence could be reworded for brevity: "The effect that Wnt signaling has on insulin activity is that it increases a cell's sensitivity to insulin"
**Suggestion: "Wnt signaling increases a cell's sensitivity to insulin."
*** Changed
Best of luck! Jnims (talk) 19:53, 8 May 2013 (UTC)
thread_title: Suggested improvments

message: Right now we have a 2004 source — "Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.". American journal of human genetics 75 (5): 832–43. . — supporting an association. Per WP:Meddate, can we get a more recent review article? The risk factor list I've assembled at DVT#Risk_factors is all cited to more recent review articles, for example. Biosthmors (talk) 23:40, 11 May 2013 (UTC)
thread_title:  Diabetes and medical information 

message: I can't read these figures: 
* Canonical Wnt pathway
* Noncanonical PCP pathway
* Noncanonical Wnt/calcium pathway
They're too small to read in thumbnails, and when I click on the thumbnails, they're still too small, and the black print on dark blue background is still hard to read. Most illustrations use color for a reason. 
And why did somebody delete the old figures, which I though gave a good explanation for somebody who wanted a synopsis before they read through the text? --Nbauman (talk) 10:02, 12 May 2013 (UTC)
thread_title:  Figures illegible

message: Substituted at 10:49, 30 April 2016 (UTC)
thread_title: Assessment comment - from 2009

message: I looked into the structure of WNT bound to Frizzled and noted that the structure shown is not the one cited:
I prepared my own structure from the data --B.Kleine (talk) 15:03, 19 July 2018 (UTC)
thread_title:  The structure shown is not a correct one 

message: Perhaps I am misunderstanding the chemistry, but I feel this page isn't clear in regards to the post-transcriptional modifications of wnt proteins. The "Proteins" section indicates it is palmitoleoyation ("The lipid modification of all Wnts is palmitoleoylation of a single totally conserved serine residue."). The citation for this statement (Hannoush, 2015), explains that wnts are preferentially palmitoleoyated but that other length fatty acids have been observed, and also claims porcupine does O-palmitolyation of wnts. In the "Regulation" section of this page, it states that wnt proteins are palmitoylated:" "For example, Wnt proteins are palmitoylated." with no citation (that sentence might also benefit from a bit more explanation especially in the context of the previous sentence indicating that regulation happens at different time points in the pathway--when/where does this happen, what is the purpose, etc). Several articles including one by the author who published citation #12 (Hannoush, 2015) indicate that Wnt3a in particular is palmitoylated by PORCN (Gao and Hannoush, 2014) (https://www.nature.com/articles/nchembio.1392), (another  example: https://www.ncbi.nlm.nih.gov/pubmed/12717451?dopt=Abstract) but a news&views article discusses palmitoleoylation of Xenopus Wnt8 (XWnt8) (Nusse, 2016) by citing Janda et al, 2012 (N&V article: Nusse, 2016:;https://web.stanford.edu/group/nusselab/cgi-bin/wnt/sites/default/files/reviews/nature14208.pdf article cited within that article: Janda et al, 2012:.https://www.ncbi.nlm.nih.gov/pubmed/22653731) Even if we are talking about palmitoleoylation as a specific form of palmitoylation (though in looking at the wording and citations in Gao and Hannoush, 2014 and Hannoush, 2015, this does not quite seem to be the case), and while I assume different wnts may have different modifications making the specifics of this subject too complex for this page, I believe clarification of this point would improve the page at least in the discrepancy in wording between the Proteins and Regulation sections. 
Emctro (talk) 20:20, 3 January 2020 (UTC)
thread_title:  Clarification about palmitoylation vs palmitoleoylation 

message: This article looks pretty complete and is out of my area of expertise, so I thought I'd flag this 2020 review article here (open access) in case it could be used to improve or update the article "WNT and β-Catenin in Cancer: Genes and Therapy". Thanks, Elysia (AR) (talk) 16:29, 12 September 2020 (UTC)
thread_title:  2020 review article that might be relevant 

message: The intro ends with "In recent years, researchers reported first successful use of Wnt pathway inhibitors in mouse models of disease.[8]" but this source is not used in the rest of the article, and it's not easy to see if this line is expanded upon anywhere in the article. - Rod57 (talk) 10:42, 7 November 2020 (UTC)
thread_title:  Tantalising lead - is it explained  

message: The WNT16B article mentions the WNT family - Is this article about the WNT family or just the Wnt signalling pathways ? - Rod57 (talk) 10:45, 7 November 2020 (UTC)
thread_title:  WNT family -  

message: This signaling pathway seems to be relevant to the blood-brain barrier, yet the article does not contain any info about that. Could you add some info about how Wnt affects the BBB and maybe also briefly mention (results from) the study "Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders"? It's currently featured in 2022 in science like so:
Neurobiologists demonstrate a Wnt7a-based approach to repair the blood–brain barrier, via GPR124/RECK agonists, as a treatment for diseases of the brain in mice.
I added a section "Protection, recovery and repair" to the article Blood–brain barrier, which seemed to be missing there to date entirely (despite the 4 scientific reviews), including some brief info about the study, but it was fully reverted.
 Prototyperspective (talk) 15:08, 24 March 2022 (UTC)
thread_title:  Please update with: info on relevance to blood-brain barrier