Talk:Metabolic syndrome

message: I am very much inclined to move this article to metabolic syndrome, which seems to be accepted nomenclature (see J Clin Endocrinol Metab of June 2004). Any views or comments?? JFW | T@lk 10:47, 8 Jun 2004 (UTC)
replies: text: You are completely right. I have no idea who inserted that. Thanks. JFW | T@lk 12:51, 31 October 2005 (UTC)

text: I have not heard the term "cardiometabolic syndrome". It may not be notable enough to be mentioned in the article. JFW | T@lk 20:34, 14 February 2006 (UTC)
replies: text: Heh. It was coined by Sanofi-Aventis to push rimonabant. I hear it in active use all the time now :-). JFW | T@lk 12:47, 12 May 2008 (UTC)
thread_title: I

message: Apparently the AHA and ADA differed in how the metabolic syndrome should be addressed. They have now agreed on some things. Do we include this?. JFW | T@lk 10:42, 21 August 2006 (UTC)
thread_title:  War is over 

message: Someone who knows how should supply mg/dL figures to supplement the mmol/L figures in this article.Rocky143 05:18, 4 January 2007 (UTC)
thread_title:  mmol/L and mg/dL 

message: The article about treatment is misleading, it says that the treatment of insulin resistance by Metformin is not FDA approved, but if you go to the article on Metformin it says that it is FDA approved.  So which is it?
--> Metformin is approved for treatment of type 2 diabetes, not metabolic syndrome  —Preceding unsigned comment added by 68.45.246.66 (talk) 12:53, 1 September 2007 (UTC)
thread_title:  Metformin 

message: I removed the symptoms in the first section because they were duplicated in the diagnosis section.  I also added the citation for Grundy.  Rhetth 00:20, 14 July 2007 (UTC)
thread_title:  I changed some stuff. 

message: This reference was left on the userpage:
:Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359, 2002
It looks useful, but it had no content associated with it. JFW | T@lk 21:16, 16 January 2008 (UTC)
thread_title:  Added 

message: In the Cardiovascular Health Study, diagnosis of metabolic syndrome by either WHO or IDF criteria made little difference in mortality compared to simply diagnosing and treating hypertension and elevated fasting glucose (EFG). Food for thought, and probably part of a trend against the use of metabolic syndrome as a bona fide diagnosis. JFW | T@lk 12:45, 12 May 2008 (UTC)
replies: text: Arch Intern Med 2008;168:969-978 JFW | T@lk 12:53, 12 May 2008 (UTC)
thread_title:  Ouch 

message: Isn't this syndrome basically obesity, caused by the usual factors attributed to obesity, such as diet, lack of exercise, etc.? Everyone knows obesity greatly increases one's risks of things like cardiovascular disease and diabetes, the same things mentioned here. I live in Japan and it's commonly said when a person's waist goes beyond a certain number of centimetres, they have metabo (i.e. metabolic syndrome). I always thought this was a bit silly, thinking 'No, they're just getting fat.' Are the two not really one and the same--i.e. the same symptoms and risk factors? Just seems to me like this is a politically correct trend word. 122.102.237.156 (talk) 03:23, 17 May 2009 (UTC)
replies: text: Not if the syndrome leads to obesity - as in the case of insulin resistance.  — Preceding unsigned comment added by 114.111.151.37 (talk) 02:00, 29 June 2011 (UTC)
replies: text: I think you've got that backwards. The weight gain causes insulin resistance. JFW | T@lk 06:26, 29 June 2011 (UTC)
thread_title:  Simply new terminology? 

message: Just a stupid question. I read the list of risk factors and am somewhat puzzled.
I just do not understand why overeating is not listed there.
Isn't this the primary cause?
Obesity is uncommon in free animals. Their instinct makes them stop eating when they had what they need.
Free animals need to be quick for survival and not fat and clumsy. So they do not overeat.
Would be nice if an expert can explain me what I got wrong or why overeating is not mentioned in the list.
Thank you. 178.25.132.88 (talk) 22:02, 6 August 2010 (UTC)
replies: text: Seems to me that overeating would be listed on the risk factors on the obesity page, but here, obesity is listed as the risk factor. Over eating is just a part of the definition of obesity. If you are over eating, but not obese, it may not be a risk factor. Of course, it may not be over eating if you are not obese.72.187.199.192 (talk) 16:42, 24 April 2011 (UTC)
thread_title:  Overeating no risk factor? 

message: A new paper is accepted an 'in press' with Archives of Medical Science under the above title
We have developed a new hypothesis regarding MetS as a
consequence of a high intake in carbohydrates and food with high glycemic index,
particularly fructose, and relatively low intake in cholesterol and saturated fat. We support
our arguments through animal studies which have shown that exposure of the liver to
increased quantities of fructose leads to rapid stimulation of lipogenesis and accumulation of
tryglicerides. The adipocytes store triglycerides in lipid droplets, leading to adipocyte
hypertrophy. Adipocyte hypertrophy is associated with macrophage accumulation in adipose
tissue. An important modulator of obesity-associated macrophage responses in white
adipose tissue is the death of adipocytes. Excess exposure to fructose intake determines the
liver to metabolize high doses of fructose, producing increased levels of fructose end
products, like glyceraldehyde and dihydroxyacetone phosphate, that can converge with the
glycolitic pathway. Fructose also leads to increased levels of advanced glycation end
products. The macrophages exposed to advanced glycation end products become
dysfunctional and, on entry into the artery wall, contribute to plaque formation and
thrombosis. More about this soon.Glynwiki (talk) 16:43, 28 October 2010 (UTC)
replies: text: You ought to provide a reference or a DOI so we can evaluate the paper here. JFW | T@lk 12:42, 29 October 2010 (UTC)

text: https://doi.org/10.5114/aoms.2011.20598. Shootquinn (talk) 00:31, 6 November 2021 (UTC)
thread_title:  Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet? 

message: "However, one study stated that these potentially beneficial measures are effective in only a minority of people, primarily due to a lack of compliance with lifestyle and diet changes." 
I'm still a wikipedia newbie, but this statement took me by surprise when I read it. A lack of compliance with lifestyle and diet changes does not prove the measures were ineffective. The participants who failed to comply fully with lifestyle and diet changes were ineffective. I think more clarification is needed on how the study reached the conclusion that the measures are effective in only a minority of people. 
Henachoko No Samurai (talk) 16:35, 28 February 2011 (UTC)
replies: text: This is tricky. If they used an intention to treat analysis, they need to look at the "real world" applicability. If a doctor advises a certain lifestyle regimen, a proportion of people will be unable to comply. That means that the overall benefit to the entire group is diluted, but it is more "real-world" than if you selected on compliance. JFW | T@lk 20:31, 28 February 2011 (UTC)
thread_title:  Measures effective in only a minority of people 

message: I haven't been part of this discussion or development of this page, so am reluctant to edit the page without some consensus (been hammered pretty bad doing that).  I have found many resources that support fructose being the primary cause of metabolic syndrome.  Fat consumption seems to be a minor issue regarding met syndrome, but the Gov't's Dietary Guidelines are incorrect in recommending high carbohydrate, low fat and low cholesterol diets.  I have purchased the two most definitive papers that I have found and have posted them in my Dropbox, online.  If you want to read the full articles, send me a message/email with your email address. I can't post them here due to the copyright issues, but I see no reason to not share them with a few interested parties.  Summaries are online, linked below. 
The citations, in sloppy format, are:
1)the role of fructose in the pathogenesis of naFlD and the metabolic syndrome, Lim et al, Nature, April 2010 doi:10.1038/nrgastro.2010.41
2) Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol, Lustig, J Am Diet Assoc. 2010;110:1307-1321 doi: 10.1016/j.jada.2010.06.008
Jwanderson (talk) 07:22, 21 July 2011 (UTC)
replies: text: Sloppy indeed. The first citation is not from Nature but from Nature Rev Gastroenterol Hepatol. There is certainly data to support this assertion, but there is insufficient consensus to label this as WP:TRUTH. You are probably correct that replacing fat with carbohydrate may be harmful, and I am sure these guidelines will soon be amended. JFW | T@lk 11:28, 21 July 2011 (UTC)
thread_title:  Fructose pretty clearly seems to be the cause of met s 

message: citation - Circulation. 2009 Oct 20;120(16):1640-5. Epub 2009 Oct 5.
Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.
Link - http://circ.ahajournals.org/content/120/16/1640.long
This article represents the outcome of a meeting between several major organizations in an attempt to unify criteria. It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool. Three abnormal findings out of 5 would qualify a person for the metabolic syndrome
Joint Scientific Statement
Harmonizing the Metabolic Syndrome
Table 1. Criteria for Clinical Diagnosis of the Metabolic Syndrome
Elevated waist circumference* Population- and country-specific definitions 
Elevated triglycerides (drug treatment for elevated triglycerides is an alternate indicator†)  ≥150 mg/dL (1.7 mmol/L) 
Reduced HDL-C (drug treatment for reduced HDL-C is an alternate indicator†)  <40 mg/dL (1.0 mmol/L) in males; <50 mg/dL (1.3 mmol/L) in females 
Elevated blood pressure (antihypertensive drug treatment in a patient with a history of hypertension is an alternate indicator) Systolic ≥130 and/or diastolic ≥85 mm Hg 
Elevated fasting glucose‡ (drug treatment of elevated glucose is an alternate indicator)  ≥100 mg/dL (5.6 mmol/L) 
HDL-C indicates high-density lipoprotein cholesterol. 
*It is recommended that the IDF cut points be used for non-Europeans and either the IDF or AHA/NHLBI cut points used for people of European origin until more data are available.  
†The most commonly used drugs for elevated triglycerides and reduced HDL-C are fibrates and nicotinic acid. A patient taking 1 of these drugs can be presumed to have high triglycerides and low HDL-C. High-dose ω-3 fatty acids presumes high triglycerides.  
‡Most patients with type 2 diabetes mellitus will have the metabolic syndrome by the proposed criteria  — Preceding unsigned comment added by 81.155.49.164 (talk) 17:40, 19 November 2012 (UTC)
thread_title:  2009 Harmonizing the metabolic syndrome: a joint interim statement on the definition of the metabolic syndrome 

message: This is not a great citation for information on diabetes, hence the reversion. A little suspicious too.
[[[http://www.simpletropicalsmoothie.com/2015/08/diabetes-mellitus-symptoms.html ~ juanTamad (talk) 07:32, 27 August 2015 (UTC)
thread_title: simpletropicalsmoothie?

message: This site can’t be reached
ppap21.stanford.edu’s server DNS address could not be found.
ERR_NAME_NOT_RESOLVED  — Preceding unsigned comment added by Aseemseth (talk • contribs) 09:12, 19 April 2016 (UTC)
thread_title:  External Link to stanford does not work 

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thread_title:  External links modified (January 2018) 

message: hello wikipedians, I edited then had my edit reverted so I undid it. In the section where I edited "People with schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder with psychotic symptoms, drug-induced psychosis or borderline personality disorder who take antipsychotic medication have higher rates of metabolic syndrome. " the cited research does not support 1) a concept of predisposition (despite how fashionable this may be), 2) exclusion of borderline, or 3) any evidence for higher rates of metabolic syndrome among those not taking antipsychotic medication. The topic is quite controversial given findings that drug manufacturers hid the relation of antipsychotics to diabetes, the neglect of health concerns for people with psychiatric diagnosis, and stereotypes of people as sedentary and poor eaters. I'm open to discussion on this but I just don't see the previous version warranted by the research. The idea that diabetes, which results from metabolic syndrome, is somehow a predisposition genetically of people which schizophrenia diagnosis seems especially egregious for an encyclopedia claiming to be evidence based. thanks.
:Responded on the user's talk page, here. --Zefr (talk) 14:20, 6 August 2018 (UTC)
thread_title:  reversion of my edit concerning research accuracy 

message: Reversion of this edit - and the WP:OR opinion in the content by  - cannot be supported by a WP:MEDRS review. Reverting again and inviting discussion per WP:BRD. --Zefr (talk) 17:49, 18 April 2019 (UTC)
thread_title:  Racial prejudice in diagnosis? 

message: The evidence is not just ample it's overwhelming. I am not going to post it here, as I 'll leave others to do the edits who are more well versed in wiki editing. One google scholar or google search with keywords metabolic syndrome and antipsychotics should suffice. Just as a token, "Metabolic syndrome is a leading cause of morbidity and mortality in patients with schizophrenia, with a prevalence rate double that of nonpsychiatric populations. Given the amount of evidence suggesting a link between atypical antipsychotic medications and metabolic syndrome, several agencies have recommended regular clinical monitoring of weight, symptoms of hyperglycemia, and glucose in chronically medicated patients with schizophrenia."	
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105724/
Please do not delete this entry, If you do I will ask for you to be penalised. It's not a rant, but a valid section that is completely missing from the article, together with research. 
--2A02:587:391E:AC00:BD5A:47FB:6383:5641 (talk) 08:06, 19 April 2020 (UTC)
replies: text: The report provided above is outdated (by 11 years) and published in a low-quality journal, so was and remains unreliable. Google isn't the place to search for information on this topic, but rather the medical review literature provides the answer: This 2018 review of reviews is one among other sources indicating no cause-and-effect relationship between metabolic syndrome and psychotic disorders or drugs: "there is insufficient evidence to clearly answer the questions on the efficacy and potential harms of antipsychotic polypharmacy". Zefr (talk) 15:18, 19 April 2020 (UTC)
replies: text: There is a clear cause and effect relationship between atypical antipsychotics (aaps) and metabolic syndrome. It's widely reported in the psychiatric literature. It should be obvious also due to the adverse metabolic effects of aaps weight gain and diabetic predisposition, these are even mentioned on the leaflets for these types of medicines. The review you posted deals with polypharmacy, and it only points out to the fact that since polypharmacy is not widely practised, there is, obviously, insufficient evidence on it. I am not well versed on wikipedia to continue with edits, or, for that matter, to know the etiquette of talk pages, but I think I am making a contribution for leaving this clearly important information here for editors to pick up on. 2A02:587:390C:DE00:D024:12DB:453:5344 (talk) 01:45, 12 May 2020 (UTC)
replies: text: I am just going to add a link https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Quetiapine-(Seroquel) , to the highly regarded and accurate National Alliance on Mental Illness that delineates some methods to decrease the chances of metabolic syndrome while on antipsychotics, for anyone interested in this and for a future addition to the entry. Wish I could do the edits, but I hope at some point someone will pick up on this. 2A02:587:390C:DE00:E09A:3019:4BE0:D5D6 (talk) 15:07, 6 June 2020 (UTC)
thread_title:  Why is there not mention that antipsychotic drugs cause metabolic syndrome?