Talk:Cyanosis

message: Blood vessels in the eye are red. They are red because there is no significant tissue to change or override the color.
Scattering is not the reason for blue. Perception problems exist in the mind. 
Photographs show that veins in the arm are blue, and veins in the region of the sclera of the eye are red.
The veins in the arm are larger, with thicker walls. Generally, muscles contain myoglobin, even venous muscular walls. What color is deoxygenated myoglobin? If anyone knows of anyone who has some evidence for the color of deoxygenated myoglobin, I would pay you for it.Anothersamespace (talk) 05:12, 18 February 2011 (UTC)
thread_title:  Red blood? 

message: Blood in normal individuals is always a shade of red, light for oxygenated blood and dark for deoxygenated.  The blue color of veins and tissues in cyanosis is due to the light-scattering effects of surrounding tissues.  The same scattering effect also causes the blue color of the sky and large bodies of water.  Blue is more lightly to be scattered while red absorbed.  Deoxygenated blood is prone to this due to its dark color (less red penetrates the tissue).  I have edited the article to reflect this fact, where it previously seemed to say that deoxygenated blood was blue.  Xiphoris (talk) 08:57, 7 February 2008 (UTC)
replies: text: You're correct. JFW | T@lk 15:27, 10 Jun 2005 (UTC)
thread_title:  Blue blood? 

message: I'm not a doctor but I heard certain poisonous agents cause cyanosis.. cyanide? CO2? May be someone better qualified could put these in the article. 86.144.47.154 23:55, 6 May 2006 (UTC)
thread_title: Poisoning

message: Is there a solution/cure for this skin discoloration problem?
In a word "Yes." In 2002 I developed cyanosis in my left arm, the first symptoms were a white hand, grey tinge to the knuckle and base of the nails on my hand. Thinking that I was cold I put a long sleeved top on. That was about 3pm. I was working on writing a scientific paper and didn't pay any attention to my hand, arm etc. I reached a point where I could stop about 6pm, and I noticed my left hand palm was a deep shade of red - similar to burgundy. I was puzzled and it was then that I noticed that the back of my hand was coloured blue. My first thought was my watch strap was too tight, so I removed it, only to discover that the blue colour continued under where my watch strap had been, I pulled my sleeve up my arm and as I did so I noticed that the blue colouring continued up my arm. It finally stopped about 1 inch - 25 mm below my left elbow. I was puzzled and sat for a few moments wondering what was wrong. Out of the recesses of my mind the word "Cyanosis" jumped at me. Now I knew I needed help and fast. I ended up in hospital for a week strapped to a pump which pumped 600 milli-litres of Heparin - a blood thinner into me. I had three times daily blood tests and was eventually put on a blood thinner tablet called "Plavix Clopidogerol" which I will have to take for the rest of my life. No one to this day (2013) can tell me what happened but since childhood if I was cut my blood clotted very quickly - had I been living with "thick" blood all my life, I don't know but what frightened me more was being told that if I hadn't sought help that day I would at best have lost my arm at the shoulder and more likely suffered a massive fatal heart attack. So yes there is a solution - thin blood carries oxygen a lot easier than thick blood, the actual cure is raising the oxygen saturation levels. I should have recognised the symptoms having been aircrew in the RAF where the causes, effects and cure for hypoxia is taught, oh and you can also be affected if you venture in to the the high mountains - mountain sickness are all caused ny hypoxia which results in cyanosis. Trust this helps.The Geologist (talk) 15:19, 9 May 2013 (UTC)
thread_title: Solution/Cure

message: Blood is always red, whether that be dark red or a lighter red. How does blood cause this blue effect, known as Cyanosis, if blood is red?
I can only presume it is the same reason veins appear blue. Tainted Deity 16:02, 9 August 2007 (UTC)
replies: text: Hemoglobin (Hb) is a tetramer (4 protein chains + iron) found within RBC's.  When the Hb is deoxygenated, I believe it is the iron content within the Hb that causes the RBC to adopt a blueish colour (I could be wrong, just going off my memory).
But reason I am here is at the end of the first paragraph it says "When signs of cyanosis first appear, such as on the lips or fingers, intervention should be made within 3–5 minutes because a severe hypoxia or severe circulatory failure has induced the cyanosis."  Should it read hypoxemia rather than hypoxia?  Cyanosis is an artefact of inadequate oxygenation of hemoglobin ie hypoxemia.  Hypoxia, as is seen in anemia will generally result in pallor (paleness) rather than cyanosis (blueness). I am under the impression hypoxemia is classified as some as a form of hypoxia, so technically it may be correct in some cases, but using hypoxia rather than hypoxemia makes it unnecessarily ambiguous... 49.2.10.223 (talk) 06:40, 8 January 2012 (UTC)
thread_title: Blood Colour

message: How about argyria? It is also about blue coloration of skin. --Hartz (talk) 18:50, 2 January 2013 (UTC)
thread_title:  Argyria 

message: This sentence doesn't make sense:
Also, the more blue the color is more difficult to detect on deeply pigmented skin. Pollifax (talk) 18:13, 21 March 2017 (UTC)
replies: text: Hello, I agree with you. I believe we can rephrase it in the following way: The blue discoloration of the skin may be difficult to detect on people with darker skin pigmentation.Joshua Cho28 (talk) 02:49, 28 October 2021 (UTC)
thread_title:  Editing needed 

message: There is a general lack in Medicine when it comes to the appearance of certain conditions such as rashes in the skin of individuals with darker skin pigmentation. In this article about "Cyanosis", it behooves us to provide pictures representing the appearance of cyanosis in people with darker skin pigmentation, in order to better educate the public. Depending on whether it is central or peripheral cyanosis, we can look at different locations on the body: oral mucosa/tongue vs. nail beds respectively.
I suggest using pictures found online. However, I do not know if there are any copyright issues. Furthermore, those pictures are the only pictures available online. Joshua Cho28 (talk) 02:45, 28 October 2021 (UTC)
thread_title:  The need for pictures representing cyanosis in people with darker skin pigmentation 

message: I propose the following edits to the headings of this article:
:Definition
:Pathophysiology
:Causes
:Evaluation
:Management
:History
:Society and culture
Joshua Cho28 (talk) 01:55, 29 October 2021 (UTC)
thread_title:  More extensive editing needed: 

message: Good job on the article, Josh! The content is appropriate, up to date, and neutral. Most of the sources are linked correctly and are secondary sources. The content added helped the article to be more complete. Below are some suggestions for improvements.
Lead
* Please consider including an introductory paragraph to briefly summarize the definition and each of the section for readers who just wanted a concise summary of the article.
Pathophysiology
* Why does a high concentration of deoxyhemoglobin cause the blood to appear blue? What makes arterial blood red? Perhaps discuss the different factors that affects oxygen delivery to end organs.
Differential cyanosis
* This section can be difficult to understand from just text and description. It would be helpful if there is an anatomic diagram of the condition. It would help to visualize the PDA’s location relative to the brachiocephalic trunk, left common carotid trunk, and left subclavian trunk.  Also, perhaps it would be wise to explain under what conditions a pressure overload of the right ventricle would occur.
* Citations are missing in this section
Central cyanosis
* Citations are missing in this section.
Peripheral cyanosis
* Citations are missing for some sentences.
* Why is there an increased concentration of deoxyhemoglobin on the venous side of peripheral circulation causing peripheral cyanosis?
* Consider restructuring this sentence to be more readable; lay person may not know what anemia is: “Since cyanosis is dependent on the concentration of deoxyhemoglobin, patients with severe anemia may appear normal despite higher than normal concentrations of deoxyhemoglobin, whereas patients with increased amounts of red blood cells (e.g. polycythemia vera) may appear cyanotic even with lower concentrations of deoxyhemoglobin” 
Evaluation
* Maybe expand a bit by explaining which tests should be used for which conditions.
Management
* This section seems a bit sparse. Please consider talking about different common conditions that can cause cyanosis and discuss management for each condition.
Images
* Some images are situated in the middle of the article instead of to the side, which can be distracting.
Future Sections Suggestions
* Prognosis/Outcome
* Special Population – Cyanosis in children and cyanosis in newborn
Checkoutchek (talk) 19:24, 15 November 2021 (UTC)
replies: text: Hello Checkoutchek! Thank you for your review. I have since made some changes in response to your suggestions:
* Moved images to the right side of the article to improve readability
* Added citations in the "Causes" section
* Added a diagram of the heart anatomy to illustrate the pathophysiology behind the effects of a patent ductus arteriosus
* Modified that long sentence to: "In other words, cyanosis is dependent on the concentration of deoxyhemoglobin. Patients with severe anemia may appear normal despite higher than normal concentrations of deoxyhemoglobin. On the other hand, patients with increased amounts of red blood cells (e.g. polycythemia vera) can appear cyanotic even with lower concentrations of deoxyhemoglobin." However, I did not define anemia as a link to the "Anemia" Wikipedia page was provided.
Thank you very much! Joshua Cho28 (talk) 12:37, 19 November 2021 (UTC)
thread_title:  Peer Review by WikiProject Student 

message: Is the condition of the Blue Fugates, who had methemoglobinemia, an example of cyanosis? I don't feel qualified to write a section about them, but it would be interesting to add such a section to this page. SnappingTurtle (talk) 18:27, 17 August 2022 (UTC)
thread_title:  Blue Fugates 

message: The main edits in the introduction were linking the medical terms to other Wikipedia pages which made it better.
The origin and meaning of the word cyanosis should've been explained within the 1st few sentences.
The addition of the last sentence is good.
The correction of the “vs” to “and” is right.
he article is relatively clear and organised. However, the history section could've been put earlier after the introduction. Also, there are many bullet points that could've been changed to organised schedules. As for the content, it's also very good but maybe the causes could've been explained simpler. Overall, its balanced, yet I find sections like causes or treatment more important to focus on than the pathophysiology as readers tend to be looking for them. The tone is also appropriate.
There was almost no edits on the References part but the mentioned facts were  appropriately supported with good resources.
The article maintains its original organization. The addition of the new reference improved the content's comprehensiveness. However, the vocabulary remains a bit complex, especially in the introduction and the Evaluation sections. The amount of medical language used may not be easy to digest by the reader. It is also recommended to increase the amount of references to further substantiate the topic.
as we mentioned earlier, the new article doesn't differ much from the original one. Only slight minor changes were done. It could be enriched with further information and citations to become more informative. At the same time, all the minor edits that were done are good and succeeded to make it simpler. Mayyasah (talk) 20:36, 25 September 2023 (UTC)
thread_title:  peer Review by wiki project / NMT OMEN Palestine