lflage/wiki-talks huggingface dataset:
Talk:Crigler–Najjar syndrome

message: This seems to me as way too few... is this sentence regarding the whole world or a specific country? (I will throw a shot in the dark and say this is regarding the USA only). Anyways, its always cool to know one's uniqueness... I was diagnosed CNS type II about 10 years ago. NeoGenPT (talk) 16:15, 27 January 2010 (UTC)
thread_title:  "only a few hundred cases of CNS are known to exist."
Talk:Crouzon syndrome

message: If anyone wants to add information about how intelligence is effected, the Genetic and Rare Diseases Information Center's 'Crouzon Syndrome' page states:
:"Intelligence is usually normal, but intellectual disability may be present." - https://rarediseases.info.nih.gov/diseases/6206/crouzon-syndrome
Thank you for your time, Wordreader (talk) 00:52, 1 October 2022 (UTC)
thread_title:  Intelligence effect.
Talk:Cystinosis

message: In nephropathic cystinosis, oral cysteamine therapy improved outcomes: http://www.annals.org/cgi/content/abstract/147/4/242 JFW | T@lk 23:57, 20 August 2007 (UTC)
thread_title: Oral cysteamine in NC

message: Citation 4: http://link.springer.com/article/10.1007/s12038-010-0004-8 is a load of junk. It does not have any data, and the hypothesis presented seems implausible. The citation and associated statement about disrupting metabolism should be removed. 173.100.77.23 (talk) 18:57, 7 January 2015 (UTC)
thread_title: Futile Cycle Paper?
Talk:Dentinogenesis imperfecta

message: This section seems to be missing a lot of info. I have this condition, and I know that part of it is that it gives you really short roots to your teeth. (Both a blessing and a curse--trips to the dentist don't terrify me because the dentist's tools don't hurt as much as they would a normal person.) Also, I don't think braces and whatnot are always a problem? I got braces without a problem... Also, another treatment for this is getting your teeth capped--I had my front six teeth capped. But, of course, I'm not sure how I would edit this page with this info as I do not have a source for them other than my own experience.  —Preceding unsigned comment added by 71.227.20.42 (talk) 15:34, 11 January 2011 (UTC)
thread_title: note
Talk:Diamond–Blackfan anemia

message: It seems that the style in which the article is written it confusing, not exactly written in layman's terms.  I think it would be great if someone with a medical background could go through the article and make sure it is easy to follow. Vikingviolinist 16:46, 8 December 2006 (UTC)
thread_title: Language level

message: An article on Dailymail.co.uk (Boy with baffling illness so rare it does not have a name is cured by his PARENTS) was published today, regarding a boy with a DBA-like illness that is being treated with amino acid therapy. As the article appeared on Digg, it is likely that folks will be showing up to take a look here. I'm going to include a link to the article in the "Clinical Management and Treatments" section, along with a reference to a peer-reviewed article from the journal Haematologica that provides a second piece of evidence supporting the amino acids.Martian bob (talk) 21:31, 10 February 2009 (UTC)
thread_title:  Dailymail article 
Talk:Ellis–Van Creveld syndrome

message: The phrase "The term, however, has been found offensive by some... For this reason, 6-fingered dwarfism has been removed as an alternative name for this entry." implies censorship. Thoughts? KarikaSlayer (talk) 18:14, 1 August 2011 (UTC)
thread_title:  Censorship? 

message: The final section states "This leaves Ellis–van Creveld syndrome with its felicitous abbreviation, EVC, as the only satisfactory designation." It's not clear what is "felicitous" about this abbreviation. I'd appreciate it if someone with that information would edit this sentence to clarify.  — Preceding unsigned comment added by Untorqued (talk • contribs) 01:14, 21 August 2014 (UTC)
thread_title:  "felicitous"? 
Talk:The Gold Range

message: There's a mountain range in BC by this name, in the Monashee Mountains; its article (not yet written) and won't need the definite article but posting this here as a reminder this page will need a dab ref at its top once it does.Skookum1 20:38, 2 January 2007 (UTC)
thread_title: sep article for the mountain range

message: Revert changes deleting mention of April 8, 2013 council decision to go ahead with "purchase" of the Gold Range? It is obvious from the previous sources posted that the city intends to force the owners to sell. By definition this is expropriation! Let's call a spade a spadeBillturner1983 (talk) 22:55, 9 April 2013 (UTC)
replies: text:  This wiki definately sugar coats this place. And I feel that the article should be changed in a way to more acurately reflect the true nature of this establishment.
1) Mention the towel material permanently stapled to the tables to soak up spilled beer.
2) Mention the hords of the cracked out the frequently hang out front.
3) This is not the kind of "tourist atraction," you would bring your mom/ grandmother... Unless of course they are raging alcoholic sketchbags...
all in all, this article makes it sound too nice. —The preceding unsigned comment was added by 76.9.32.109 (talk) 17:57, 5 May 2007 (UTC)

text: I brought my mother there and it was great -- and we aren't the "raging alcoholic sketchbags" you assume. She lives in Toronto and it was definitely a "new" experience for her!--Agnaramasi 03:32, 20 August 2007 (UTC)
thread_title: Gold Range Expropriation?

message: eighteen years ago in thr winter of 1989-90, I traveled to Yellowknife to play with PaPa Spain and the Stampede Band at the Gold Range Hotel.  What an experience. Thirty and forty below while we were there over the holidays. Pretty good money, about eight hundred a piece a week.  Not bad for some hacks from Portland Oregon.
Found out our singer was a phyco shoplifter criminal and had to fire her the first week there and reform the band. Luckily, a few good players around yellowknife, including Canadian legend Dave Boyer to help out. Sams place could be pretty routy and given its size could be almost overwhelming. We heard Sam could be a rough character, but he was good to us and servered us a good Christmas dinner to make for being away from home. PaPa just passed away at eighty one last week. My heart aches over his loss. One of the best fiddle playing buddies a friend could have and what a one of a kind type character Papa was. He was still playing locally till a stroke took him sudenly. Our trip to Yellowknife was the experience of a lifetime that neither of us ever grew tired of reliving and talking about. Heres to my pal PaPa and Yellowknife. Miss you'
Mike Severin/ Welches Oregon USA
- moved from article, originally posted by User:71.111.30.143. - Trevor MacInnis (Contribs) 19:20, 29 January 2007 (UTC)
thread_title: Remembrance
Talk:Epidermolytic hyperkeratosis

message: Should I mention the poor quality of the writing? This doesn’t read at all like an encyclopedia article, but if anything more like something out of a magazine…
//BrianRecchia (talk) 18:51, 9 June 2018 (UTC)

message: :Moving some unreferenced text from section that can be rewritten. Whispyhistory (talk) 15:39, 19 May 2024 (UTC)
thread_title: Moving some unreferenced text to talk page
Talk:Erythropoietic protoporphyria

message: Hello, 
If somebody wants to translate the german wiki -articel about EPP, you ´ll find it there: 
http://de.wikipedia.org/wiki/Erythropoetische_Protoporphyrie
I am sorry for my english, it´s just not good enough to do the translation by myselfe... 
Greetings from Germany, Mauersegler77
: I think this Google translation would be an excellent starting point.  Barring any objections, I'll work on it when I have the time. Argonel42 (talk) 06:33, 27 August 2009 (UTC)
thread_title:  German Wikipedia page 

message: Paragraph Four is incorrect. EPP has absolutely no symptoms related to pain of the stomach.  some other types of porphyria manifestas pain in the stomach, but not EPP.
http://www.porphyria.uct.ac.za/professional/prof-epp.htm
— Preceding unsigned comment added by Wikiusername1234 (talk • contribs) 00:54, 20 August 2011 (UTC)
thread_title:  Non-cutaneous symptoms not part of EPP 

message: I wonder if this article should be merged with the more general one on 'porphyria'. This would also apply to the article on acute intermittent porphyria.Doctorpete 08:23, 25 May 2007 (UTC)
replies: text: I'd recommend not merging. --Arcadian 14:11, 25 May 2007 (UTC)
thread_title:  ?merge 

message: is specifically about the liver disease in EPP. JFW | T@lk 21:12, 13 June 2007 (UTC)
thread_title:  Liver disease 

message: It was reported today that the Italian Medicines Agency has authorized the usage of the drug melanotan-1 (generic name "afamelanotide") as photoprotective inducing agent to help EPP sufferers tolerate light better. To my knowledge this is the first therapeutic medicine of this type authorized anywhere in treatment of EPP. I think this bears mentioning in this article but I am wondering what the views of other editors might be?
Thanks,
-Scott / Melanotan (talk) 23:31, 17 May 2010 (UTC)
thread_title: New therapeutic drug approval in Italy
Talk:Familial Mediterranean fever

message: Ann Intern Med this week - Anakinra helps if colchicine fails or is poorly tolerated. JFW | T@lk 22:37, 4 June 2007 (UTC)
replies: text: Or rilonacept doi:10.7326/0003-4819-157-8-201210160-00003. Same journal incidentally. JFW | T@lk 23:20, 17 February 2014 (UTC)
thread_title:  Anakinra 

message: - Br J Haematol JFW | T@lk 19:40, 12 August 2009 (UTC)
thread_title:  Review 

message: This was added:
:Some research has been done to investigate the connection of amyloidosis and Familial Mediterranean Fever, and studies have found that an important variation in this particular complication arises from the Met694Val and Val726Ala mutations. More specifically, individuals who are homozygous for Val726Ala seem to be protected from developing amyloidosis, while those who are homozygous for Met694Val or compound heterozygous for Val726Ala are susceptible. However, there is evidence to suggest that those who are heterozygous for Val726Ala may respond well to regular treatment with colchicine, thus preventing them from developing renal amyloidosis.Yalçinkaya, F., MD, Akar, N., M.D., & Misirliolu, M. (1998). Familial mediterranean fever--amyloidosis and the Val726Ala mutation [letter]. The New England Journal of Medicine, 338(14), 993-994.
This needs a secondary source. JFW | T@lk 10:58, 6 December 2020 (UTC)
thread_title:  Added 

message: I recently removed some unsourced information added by a Wikipedia user who personally experiences familial Mediterranean fever. I was unable to find any external source to substantiate their experiences, but have added a message to their talk page to prompt for further information. If anyone feels this should be reinstated, just let me know so we can avoid a removal war! Guidance is available on which sources are appropriate. --AlexVojProc (talk) 22:55, 19 May 2022 (UTC)
thread_title:  Unsourced anecdotal symptoms 

message: The redirect Epidemiology of Familial Mediterranean fever in the United States of America has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  Fram (talk) 08:46, 6 November 2023 (UTC)
thread_title:  "[[:Epidemiology of Familial Mediterranean fever in the United States of America]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]]
Talk:Fanconi anemia

message: Suggestion: to change the article's name to "Fanconi's Anemia", which is how it's called in ICD-10  —Preceding unsigned comment added by Alice.odin (talk • contribs) 01:34, 24 June 2010 (UTC)

message: What are the odds of two brothers (boy and girl) having this disease?  — Preceding unsigned comment added by 64.64.76.40 (talk) 19:23, 30 November 2011 (UTC)
thread_title:  what are the odds? 

message: This article should include more history than the single sentence it currently has. Chris857 (talk) 22:22, 31 March 2013 (UTC)
thread_title:  History 

message: Recommendations from panel doi:10.1210/jc.2014-4357 JFW | T@lk 08:42, 11 January 2015 (UTC)
thread_title:  Endocrine disorders
Talk:GAPO syndrome

message: I will be continuing to update this page in the near future, as part of the requirements for my Advanced Genetics class at Western University. I plan to remove the information about autosomal recessive inheritance, as I believe this should be contained to its own page. I will add sections addressing common signs and symptoms, the genetics behind it, screening and diagnosis, among others. I intend to structure the general framework of the article using the very well constructed Down Syndrome page as a general template
Nwerry (talk) 18:14, 10 October 2015 (UTC)
thread_title: Untitled

message: It reads: 
"While not a defining feature, most sufferers of GAPO syndrome have coarse facial features, and abnormal structure of the middle portion of their faces, typically coupled with a large forehead.[2] Individuals with the disease tend to have depressed nose bridges, protruding ears, and abnormally thick lips, though these symptoms are not unique to this disorder"
Maybe stick another photo on the wikipage showing the 'coarse effect' nearer to the phenotype that can be seen in the GAPO syndrome photos on the internet?  — Preceding unsigned comment added by 2A02:C7D:411:1600:226:8FF:FEDC:FD74 (talk) 14:20, 7 May 2016 (UTC)
thread_title:  coarse facial features image
Talk:GM2-gangliosidosis, AB variant

message: A disease variant that is a footnote, and nothing more. No new studies have been reported in Online Mendelian Inheritance in Man in the last ten years. There is nothing more to do here ... it would be a waste of time. Metzenberg (talk) 10:32, 22 April 2009 (UTC)
thread_title:  Done 
Talk:Gitelman syndrome

message: Article relies almost entirely on discipline-specific jargon that is not accessible to a general audience, the subject symptoms are described through a simile to another esoteric subject instead of through explication, and almost all descriptive terms are also jargon. I will come back and do what I can when I am less pissed off at the complete disconnect between medical writing and accessible vocabulary.
— Preceding unsigned comment added by 99.232.0.210 (talk • contribs) 02:03, 24 March 2010 (UTC)
thread_title: Untitled
Talk:Glycogen storage disease type I

message: Hi, I have a degree in biochemistry and I know that humans can't make glucose from acetyl-coa, as stated in the article.
:you are right; fixed; thanks and please contribute alteripse 22:25, 18 March 2007 (UTC)
replies: text: It's now mentioned beginning in the Genetics section of the article.  We might want to first mention it earlier. RJFJR (talk) 22:27, 23 December 2017 (UTC)
thread_title: note

message: please answer is needed:
if you read physiology: potassium compete with hydrogen ions for excretion by the kidney.
and I am oriented that acidosis result eventually in hyperkalemia & hyperlalemia result eventually in acidosis.
why he recommended giving KCl in case of acidosis ! ! 
I believe that there was misunderstanding because the example given was repeated vomiting, so the source possibly was talking about the treatment of the vomiting, not the treatment of acidosis episode in GSD 1
yasir al-bayati  — Preceding unsigned comment added by Yasir muhammed ali (talk • contribs) 19:20, 16 March 2018 (UTC)
thread_title:  Why adding  KCl ??
Talk:Glanzmann's thrombasthenia

message: is a recent review.  describes recent efforts of reduced-intensity bone marrow transplant in severely affected children. JFW | T@lk 21:25, 10 February 2008 (UTC)
thread_title:  Sources 

message: should be absent gp 2b 3a fibrinnogen receptors.  it doesn't say receptors, does it?  —Preceding unsigned comment added by 207.151.230.101 (talk) 03:27, 4 April 2008 (UTC)
thread_title:  pretty sure this is wrong 

message: Pathophysiology section poorly detailed and wrong in places. Causes section doesn't even mention cause, just symptoms and random facts.  — Preceding unsigned comment added by 24.154.245.226 (talk) 16:14, 17 August 2013 (UTC)
thread_title:  Needs rewritten badly 

message: I think the different types of this disease needs to be mentioned. Angunnu (talk) 15:33, 4 November 2019 (UTC)
thread_title:  Types
Talk:Glutaric aciduria type 1

message: Subject: Oldest sufferer of GA1
Further to information provided, a recorded case of a female living on the Gold Coast, Australia suffering with GA1, who is now at the age of 37. Currently being treated through Gold Coast University hospital. 
Kelly was diagnosed at the age of 17, and also suffers from Bipolar and Manic Depression. 
Link to article published in the New Zealand Medical journal below. 
https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2015/vol-128-no-1409/6440
Chrisandkelly (talk) 22:50, 22 June 2017 (UTC)
thread_title: note
Talk:Weston Reservoir

message: I'll try to get a photo this weekend LymanSchool 17:57, 12 October 2006 (UTC)
thread_title: Untitled

message: reverted changes made by anonymous because they were not supported by any references. I don't care if you "work there". If there isn't a public document that can be referenced, then the facts don't exist. The latest document I could find, that show the MWRA facilities, is a court order listed in the references. That is what the MWRA overview was based upon. Also, don't substitute [ [MWRA] ] for [ [Massachusetts Water Resources Authority|MWRA] ]. It creates a redirection. LymanSchool 16:08, 24 October 2006 (UTC)
thread_title: MWRA Overview
Talk:Derek Lee Ragin

message: I think this article needs some NPOV work and some citing. Also, I should probably try to figure out if it's actually a copyvio from his publicist. I'll work on it when I get home. Mak (talk) 17:58, 12 October 2006 (UTC)
thread_title: Untitled

message: I removed The only non-blended recording of Ragin on the Farinelli soundtrack is Cara sposa. from the article because I can not find any reliable source to prove the claim.--Caspian blue 04:17, 20 October 2009 (UTC)
thread_title:  Unreferenced sentence 

message: Can his African-American heritage be explicitly specified? Currently, it can only be gauged from the list of categories at the bottom.--Adûnâi (talk) 22:02, 30 June 2018 (UTC)
thread_title:  African-American heritage
Talk:Holt–Oram syndrome

message: And what percentage are sporadic / not-inherited ? - Rod57 (talk) 11:25, 24 April 2013 (UTC)
replies: text: Hi Rod57. According to Gene Review, about 85% of cases are new mutations, not inherited. (I added it to the Genetics section.) IlexOpica (talk) 01:33, 19 April 2018 (UTC)
thread_title:  \what percentage of cases are inherited from a parent
Talk:Hyper-IgD syndrome

message: - review of all related conditions. JFW | T@lk 11:44, 29 April 2007 (UTC)
thread_title:  Review 

message: added that lovastatin caused severe crises rather than reducing attack frequency. I could not identify the paper in question (Houten 2003, no full citation provided). However, I suspect  is the main reference; this study is about homozygous MK mutations causing mevalonic aciduria. Despite similarities, I don't think we can generalise results from that condition to HIDS. JFW | T@lk 16:32, 24 January 2008 (UTC)
replies: text: documents benefit from simvastatin 80 mg. JFW | T@lk 19:59, 24 January 2008 (UTC)
thread_title: Statins

message: Only Medicine (Baltimore) seems to carry these case series: . JFW | T@lk 21:20, 14 October 2009 (UTC)
thread_title:  Case series 

message: This article was categorized based on scheme outlined at WP:DERM:CAT. Calmer Waters 12:09, 2 February 2010 (UTC)
thread_title:  Article categorization 

message: Hi... I suggest that the following articles to be merged:
* Hyper-IgD syndrome
* Mevalonate kinase deficiency (HIDS)
* Mevalonate kinase deficiency
--محمود (talk) 23:06, 26 August 2016 (UTC)
replies: text: Yes agree. User:Jfdwolff wrote the original. He might be best to take care of it. Doc James (talk · contribs · email) 01:41, 27 August 2016 (UTC)

text: I would object to merging everything. MKD and HIDS are different disease entities, the former causing much more severe symptomatology while the latter (this article) causes a periodic fever syndrome akin to familial Mediterranean fever and TRAPS. Of course all are rare conditions but they are different. JFW | T@lk 09:14, 29 August 2016 (UTC)
thread_title:  Merge articles 

message: * as those involved in previous discussion. PamD 16:24, 9 July 2018 (UTC)
replies: text: Hmm, I didn't see the talk page discussion above before proposing the merge... but it still seems logical given the two points I made in the merge proposal. PamD 16:17, 9 July 2018 (UTC)
replies: text: If they are not to be merged, then there needs to be more clarity in the lead paragraphs explaining the differences between them, especially given that NHS England appears to consider them to be the same thing. PamD 16:19, 9 July 2018 (UTC)
replies: text: Support merge on the grounds that they are either equivalent or so similar that the differences are best discussed on on page. OMIM does have a separate page for HIDS with the alternative title of PERIODIC FEVER, DUTCH TYPE under 260920. However, they note at the start that . The MVQ OMIM entry has a larger and more detailed secton on Hyper-IgD Syndrome, and lists Hyper-IgD Syndrome as an allelic variant. Hence, as a rare allelic variant it is best discussed on the same page. Klbrain (talk) 08:05, 19 August 2019 (UTC)
replies: text:  Klbrain (talk) 21:03, 25 October 2019 (UTC)
thread_title:  Proposed merge with [[Mevalonate kinase deficiency]]
Talk:Hyperkalemic periodic paralysis

message: This problem seems to be gettihg worse each year. Our doctor's can not place a dx. so we have a tough time getting any kind of money (SSI disability) Some days he is very active , his walk is abnormal and other days his arm or legs give out and he lays on the floor from 5-30 min. The he will need to use his cane.  This has been going on since 2003. I will refer this article to our general Doc. This disease was initially blamed on taking of Mevacor (statins), which he took for at least 5 years, even increased while all the symptoms began, but the Cardiologist, refused that notion.
Not sure this is the right page to write to, but my spouse ,age 53yr. is really concerned.
Thank you (97.125.36.96 (talk) 19:32, 4 August 2011 (UTC)
replies: text: WP can't help you, we just write articles on the topic, best to look for medical web sites and chat boards.  Sorry. Montanabw(talk) 20:12, 4 August 2011 (UTC)
thread_title:  I have concern for my spouse about muscle periodic paralysis and severe weakness 

message: I think it would be clearer for readers if the horse disease and the human disease were on different pages. The disease is more common in horses than humans. However, most (all?) articles about medical conditions which have the same name in humans and in veterinary species seem to have the primary page at the human disease, and use a disambiguator for the animal disease. Therefore, I suggest leaving the human disease at Hyperkalemic periodic paralysis, and moving the horse disease to Hyperkalemic periodic paralysis (equine). What does anyone else think? DferDaisy (talk) 21:23, 13 May 2018 (UTC)
thread_title:  Propose article split