Talk:Generic drug

message: http://www.amsa.org/hp/RandD.cfm
I've read several articles discussing the fact that the "Incredible R&D" costs may incurred by drug companies may not be true, and in many cases it is the government or universities that develop drugs that companies then patent and market.
I have also seen statements that drug companies spend more on marketing then R&D.
Would this type of discussion be appropriate to this article, or should this go somewhere else?
:It would probably fit best into Pharmaceutical company but putting a taste of it here wouldn't be unreasonable.  It could even get its own article.  Justforasecond 05:57, 26 July 2006 (UTC)
thread_title:  Research vs Marketing Costs 

message: Not exactly a complaint with this page, but it would be nice if wikipedia pages regarding specific prescription drugs give a year as to when the patent will/had expire.
:Drug patents last 20 years (roughly 12 years on the market when you factor in research and clinical trials). This page tells you when they go off patent, but you have to subscribe to get all the features http://www.drugpatentwatch.com/premium/preview/.  Justforasecond 05:01, 16 July 2006 (UTC)
thread_title:  When do drug patents expire? 

message: Generic drugs manufactured primarily in India? What? Of all the generic companies I'm familiar with, only one of them has any relation to an Indian company; most of the others are American, and one is Israeli. Can someone get a source for this statement? Otherwise, I think it should be removed. Archmage Brian 03:19, 21 July 2006 (UTC)
replies: text: Try Ranbaxy, Dr Reddy's, Teva.    Justforasecond 07:03, 21 July 2006 (UTC)
replies: text: Teva is the largest worldwide and actually the one from Israel mentioned by Archmage Brian. -- Alfie (talk) 11:10, 15 June 2008 (UTC)
thread_title:  Geography and sources 

message: I think the 800,000,000 dollar figure for the amount to get a drug to market needs a citation.  I have heard a number of different figures that vary massively.
:Yes, I agree. I actually have the article right in front of me now, it's from an article called The price of innovation: new estimates of drug development costs by Joseph A. DiMasi et al. They conclude that the out-of-pocket cost per new drug is $403 million and by capitalizing this cost to the point of market approval at a real discount rate of 11% this yield a total cost of $802 million. I'll add the reference on the main page. Uapan 14:00, 9 January 2007 (UTC)
thread_title:  Citations 

message: Perhaps inadvertently, the article seems to talk around what I would have thought was a key issue: Is a given generic drug by definition the same molecule as its brand-name counterpart?  Does the FDA require this?  The article defines "generic" in terms of bioequivalence and says explicitly, "Bioequivalence, however, does not mean that generic drugs are exactly the same as their innovator product counterparts, as chemical differences do exist."  I guess that answers my question.  But if a difference in chemical composition is allowed, then isn't the generic drug actually a different drug?  Couldn't it be patented and marketed accordingly?  In other words, couldn't the generic-drug maker (or competing brand-name maker) have created the "chemically different" drug before the expiration of the patent of the brand-name counterpart and begun selling it then?  Anyway, I think the quoted sentence on bioequivalence/chemical differences could use some expansion. Tawagoto 02:32, 8 November 2006 (UTC)
replies: text: “[…] as chemical differences do exist.” is a rather confusing expression for the non-expert. Actually the “active moiety” may be identical (then it’s called a “pharmaceutical equivalent”), or a different salt or ester (a “pharmaceutical alternative”). Details are given in 21CFR320.1. http://edocket.access.gpo.gov/cfr_2008/aprqtr/21cfr320.1.htm Actually both salts and esters are cleaved in the stomach and only the base finally enters the systemic circulation. If I remember it correctly there were a couple of innovators filing lawsuits against their competitors from the generic industry, but never succeeded in demonstrating a difference in bioavailabilty (i.e., bioinequivalence). I will try to alter the sentence in the article. -- Alfie (talk) 01:38, 15 June 2008 (UTC)
thread_title:  Same molecule or not? 

message: I agree that this article doesn't have a neutral point-of-view. It seems to present the debate on the role of generics primarily from the drug developers' POV. I have changed the introduction, but the rest of the article needs work. Especially the section on Reasons for a Cheaper Price.  For instance, just the word cheaper rather than lower reveals an attitude.   Ben 09:58, 17 April 2007 (UTC)
replies: text: I've made extensive changes, and I feel the article now satisfies NPOV. For that reason, I've removed the tag. -RustavoTalk/Contribs 17:43, 19 June 2007 (UTC)
replies: text: The introduction still seems to be drug company POV. E.g. "In some countries, like Brazil, more than 20% of all drug sales are generic." By using a developing nation "like Brazil" as an example, it gives the impression that generics are for who are living in a country "like Brazil". France used "only" 21.5%  and considered itself behind European standards.  "The FDA's use of the word "identical" is very much a legal interpretation, and is not literal." sounds like FUD. I am going to change Brazil to France and {citation needed} to the "FUD". --Timtak (talk) 00:41, 13 April 2015 (UTC)
thread_title:  Tone: NPOV 

message: The following is not true, in my opinion:
:The principal reason for the relatively low price of generic medicines is that these companies incur fewer costs in creating the generic drug, and are therefore able to maintain profitability while offering the drug at a lower cost to consumers.
A company can't manufacture a drug more cheaply just because it didn't invent it. Invention costs should have either been recovered during the life of the patent, or written off. The real reason that generics are cheaper is that they are subject to competition, so monopoly pricing doesn't apply. Horatio 23:15, 21 September 2007 (UTC)
thread_title:  Reason for low price 

message: I added some to the discussion of price competition between generics to include competition between generics and name-brand drugs and linked to step therapy.
Theophan (talk) 17:31, 11 July 2008 (UTC)
thread_title: Added Link near the end of the economics section

message: FDA redesigned their website without automatic redirects (pros at work). Since June 2009 most links are broken. I'm a little short in time, but we have to fix it. Some references to old/new links are given here. -- Alfie±Talk 10:08, 9 July 2009 (UTC)
thread_title:  Broken weblinks in references 

message: 2 things. One, when did generics start appearing? And why not before? Two, tho I can't cite, I've seen news reports of major brands extending patent protection by making claims on the shape & color of the pill. This (in a way I don't understand) locks out the generics while a judge studies the issue... These things need inclusion.  TREKphiler hit me ♠  02:10, 16 October 2009 (UTC)
thread_title:  Patently missing 

message: This article had a minor error suggesting that 80%-125% was a range that had deviation of 45%, I changed it to 25%, since the width of the range is not its deviation from the standard.Fireemblem555 (talk) 06:47, 24 January 2010 (UTC)
thread_title:  Fixed a Math Error 

message: While it may differ by jurisdiction, in the U.S., frex, in some places, pharmacists may be prohibited from subsituting a generic even if a patient specifically requests it. TREKphiler any time you're ready, Uhura  15:41, 10 April 2011 (UTC)
thread_title:  Disallowed 

message: This article is very US-centric. There's no explanation how patents apply on international level, etc. Litawor (talk) 10:15, 14 March 2012 (UTC)
replies: text: I came here with the same complaint. I would love for someone to propose a source which talks about this internationally.  Blue Rasberry (talk) 20:00, 17 April 2013 (UTC)
thread_title:  Outside US? 

message: Is there ANY place/way for this "idea" in this article?
http://management.fortune.cnn.com/2013/01/10/generic-drugs-quality/
Maybe it's already covered under "bioequivalence"...?
I earlier tried adding:
According to CNN, "Consumers are told that generics are just like their name-brand counterparts. More medical professionals are starting to say that's not the case." [5]
but it was reverted... Curious1i (talk) 01:40, 27 March 2013 (UTC)
replies: text: I work for a consumer organization which gives health information and we often publish statements saying that generic drugs are equivalent to branded drugs. Often we get our information from medical specialty professional organizations. I am not sure what the final authority on these matters are, but Fortune magazine is not it even though it may be all right to include in this case. The right source is probably a medical organization and there might even be variation in the quality of generic drugs from country to country; I am not sure. If anyone knows of any international study in equivalency standards of generic drugs to any branded drugs then I would like to see it.  Blue Rasberry (talk) 20:03, 17 April 2013 (UTC)
thread_title:  Are generics really the same as branded drugs? 

message: I have been considering whether Wikipedia articles on various drugs should state whether the drug which is the subject of the article is available in a generic form. The biggest problem with this is that this can happen at different times in different countries, and I am not sure where to look to find out where it is generic. I am often interested in older drugs which could conceivably be off-patent everywhere. Is there such thing as a list of drugs which are available in generic forms worldwide? Has anyone seen any source which lists which drugs are available as generic in various countries?  Blue Rasberry (talk) 20:09, 17 April 2013 (UTC)
replies: text: They should and many do.  Good question.  I'd say one reliable thing to do to get info is to look up the patents.  Because patent holders are sure to lie/mislead about whether stuff is patented.  Patent pending and all.   There are several great, free, complete US patent databases on the 'net,  (optimistic but not sure about the rest of the world, sorry) and thanks (*cough*) to intellectual property treaties like the TPP and others already in effect, availability of generics is becoming more and more uniform.  But there are a handful of countries where, by law or by practice, generics are available even when a medication is still protected by patent in most places.  India is most well-known.  I'm adding some rough relevant content now...  --Elvey(t•c) 05:32, 1 July 2015 (UTC)
thread_title: Opinions on stating whether a drug is available in generic form

message: I just restored this:
Re. "the cited reference does not say anything about manufacturers, wholesalers, and drugstores raising prices in response to patent term restoration" umm... but the cited reference does say stuff about manufacturers, wholesalers, and drugstores raising prices.  So don't remove properly sourced content and make a straw man argument in an attempt to justify it. 
Re. "not true - the largest generic manufacturers like Teva and Mylan are independent are not owned by branded pharma companies (see corresponding articles))"  Umm.  It's fully sourced content from a reliable source.
Re. "it's illegal to do this and has been punished by heavy FTC fines" - well again, It's fully sourced content from a reliable source. And since you admit it has been punished by heavy FTC fines, you're implicitly admitting that it happens.   So don't remove properly sourced content and make a bogus argument in an attempt to justify it. --Elvey(t•c) 05:32, 1 July 2015 (UTC)
thread_title: Sourced content

message: A best way to organize content, after general concepts, is by country. The sales, regulations, etc. are different, and result in very distinct scenarios. --Krauss (talk) 02:49, 29 March 2014 (UTC)
thread_title:  Market and regulation by country? 

message: There was a paragraph in this article about the FDA citizen petition process. I just created an article for that and cut the content here to paste it there. The concept can expand at that article, as this part of United States regulation is WP:UNDUE for expansion in this article about generic drugs in general.  Blue Rasberry (talk) 17:11, 8 March 2017 (UTC)
thread_title:  New article - FDA citizen petition 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Generic drug. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20100528121805/http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/index.htm to http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/index.htm
*Added archive https://web.archive.org/web/20091222220346/http://www.emea.europa.eu/sitemap.htm to http://www.emea.europa.eu/sitemap.htm
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 17:07, 12 October 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Generic drug. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Corrected formatting/usage for http://www.cjcp.ca/pdf/CJCP_04-043_e229.pdf
*Added archive https://web.archive.org/web/20091020094049/https://www.nps.org.au/health_professionals/activities/pharmacy_assistants_kit to http://www.nps.org.au/health_professionals/activities/pharmacy_assistants_kit
*Added  tag to http://recherche-search.gc.ca/s_r?t3mpl1t34d=2&s5t34d=canada&l7c1l3=eng&S_08D4T.1ct57n=search&S_08D4T.s3rv5c3=advanced&S_S20RCH.l1ng91g3=eng&S_S20RCH.p1r1m3tr5cF53lds=department%2Cparamdocyear&S_F8LLT2XT.5gn7r36p3r1t7rs=true&S_F8LLT2XT=generic+drugs&S_F8LLT2XT.t3xt6p3r1t7r=OR&S_d1t3fr7m.f53ld=documentdate&S_d1t3fr7m.d1t36p3r1t7r=gt&S_d1t3fr7m.v1l93=&S_d1t3t7.f53ld=documentdate&S_d1t3t7.d1t36p3r1t7r=lt&S_d1t3t7.v1l93=&S_m5m3typ3.sp3c5f53r=INDEX&S_m5m3typ3.t3xt6p3r1t7r=OR&S_m5m3typ3.v1l93=&S_S20RCH.d7csP3rP1g3=10
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 11:45, 22 December 2017 (UTC)
thread_title:  External links modified 

message: A term 'Branded Generic' can be added in the article along with its meaning. -- Dr. Abhijeet Safai (talk) 06:03, 24 February 2021 (UTC)
thread_title:  Addition of a term - Branded Generic