Talk:Hypothalamic–pituitary–adrenal axis

message: This page was merged. If it looks okay to the doctors around, please feel free to remove the cleanup tag. Ste4k 05:40, 14 July 2006 (UTC)
thread_title: Cleanup

message: AS the article stood before I made a few explanatory additions it was short on basics and long on bald statements that are only half-correct. It still needs more work. Essentially the basic nature of the HPA axis needs explaining and some of the finer details need leaving out: this is not after all a medical textbook. Nervous and hormonal inputs to the hypothalamus cause release or not of the releasing hormones that control the pituitary; this is the crucial point and it is not properly made. The pituitary hormones GH, Prolactin (Acidophils) and basophils: FSH, ACTH, LH and TSH are then released and do their thing. The adrenals also need a bit more explaining: basic cortex versus medulla differences and how the secretions (into the bloodstream) then feedback onto the H and the P of the axis. Maybe a few practical considerations also: for example to get proper GH secretion (vital for anti-ageing, healing, body maintenance, etc) you need Phase IV sleep before midnight, etc. Lgh 02:39, 24 July 2006 (UTC)
thread_title:  HPA 

message: The "pituitary adrenal axis" section of the article (which I assume was added during the merge) seems to be a duplicate of the main article, and is very badly written. As far as I can see it doesn't really have any information that isn't included in the main section, so I have removed the section. If anyone has any objections, feel free to discuss it here (or make changes). --Sciencewatcher 23:10, 7 March 2007 (UTC)
replies: text: Well, speaking as a neuroscience professional I can tell you that we really don't understand any aspect of the brain very well at the system level.  The HPA axis is not unusual in that respect. Looie496 (talk) 01:36, 25 April 2010 (UTC)
thread_title:  Pituitary Adrenal 

message: As a lay person reading this article it does provide some useful background. However, I also observe that it essentially lacks citations to reference sources, so it could also be summarising original research or worse a piece of fiction. The overview and anatomy sections have no citations.  The function section cites three references for specific points, but in non-standard format '(MacHale, 1998)', '(Backhaus, 2004)', '(Pruessner, 1999)'.  It is also unclear as to the general source of the function section. Is this reference 2?  However, even if it is, this is a briefing on the British Society for Neuroendocrinology website, rather than a properly peer reviewed paper in a primary medical reference publication. 
This article falls short of a B quality criterion. — TerryE (talk) 11:17, 18 February 2009 (UTC)
replies: text: I agree that this is better described (according to the mid-2008 standards revisions) as a C class article.  However, the refs that you complain about are a standard format:  please read WP:Parenthetical referencing.  WhatamIdoing (talk) 00:41, 22 February 2009 (UTC)
replies: text: I just noticed that there are still a lot of citations missing, especially in the lede. Also there is stuff in the lede that isn't mentioned anywhere in the main article. --sciencewatcher (talk) 19:03, 29 April 2014 (UTC)
thread_title:  Lack of references and Citations 

message: Vasopressin is not transported to the anterior pituitary. It is transported to and released from the posterior pituitary. Hundreds of medical texts substantiate this, but here is one respected source http://www.uptodate.com/patients/content/topic.do?topicKey=~sAx8p4UzDeKUx (http://www.uptodate.com/patients/content/topic.do?topicKey=~sAx8p4UzDeKUx).
There are a number of other factual inaccuracies and half-truths in the article, and as I have time, I'll try to add more to this discussion.
On2flight (talk) 04:17, 9 December 2009 (UTC)
replies: text: This may be a stupid question, but why would vasopressin need transporting to the posterior pituitary if it originates there? Spiral5800 (talk) 18:36, 28 December 2009 (UTC)
replies: text: When a substance is released by the axon terminals of neurons, it can be synthesized at the cell body, and then transported along the axon to the point where it is released.  That's what On2flight says happens here, and the source substantiates it. Looie496 (talk) 19:12, 28 December 2009 (UTC)
replies: text: Ah, as an individual working in the neurosciences I am of course familiar with the process whereby substances are made in the cell bodies of neurons and then transported along the axon to the axon terminals.  Perhaps I didn't read closely enough, as I was thinking on a more macrocellular level; that is, I had in mind active transport between distinct brain areas and between groups of neurons rather than within individual neurons.  Next time I'll check out the source a user is citing; I just thought it couldn't hurt to pose such a succinct simple question ;)  Thanks.  Spiral5800 (talk) 20:19, 29 December 2009 (UTC)
replies: text: On2flight is wrong: Try reading the source he gives.  —Preceding unsigned comment added by 88.104.230.205 (talk) 07:10, 22 December 2010 (UTC)
thread_title:  Disputed 

message: This review has 194 citations and should probably be added. See here and full-text here. --sciencewatcher (talk) 04:18, 19 February 2011 (UTC)
replies: text: You are welcome to edit this article to make it more correct. Looie496 (talk) 23:23, 4 September 2011 (UTC)
thread_title:  Review of HPA axis, stress and disease 

message: In the intro you write "A wide variety of species, from single cellular to multi-cellular organisms including humans, share components of the HPA axis."
Somebody has correctly put the "citation needed" because they doubt that this is correct. I also think that the APH-Axis and corticosteroids are common to vertebrates only. While it is correct to say that insects and other invertebrates have similar systems with similar functions in stress response,they do not have this axis and do not synthesise steroids. See: 
I suggest therefore:
While steroids are produced only by vertebrates, the physiological role of the HPA axis and corticosteroids in stress response is so fundamental that analogous systems can be found in invertebrates and monocellular organisms as well.  — Preceding unsigned comment added by Alpengruebler (talk • contribs) 16:48, 5 January 2013 (UTC)
replies: text: Thanks for your edits.  This article has been rather neglected, and you should feel free to make any edits that seem right to you.  Regards, Looie496 (talk) 18:10, 5 January 2013 (UTC)
thread_title:  Presence of an HPA axis in animals 

message: Perhaps some mention of cortisol awakening response should be added (other than just a link to the article). --sciencewatcher (talk) 04:55, 29 April 2014 (UTC)
thread_title:  CAR 

message: Hello All! I am a student at Carleton College and I would like to expand on the Immune System section of this article for my Immunology course.  Here are six sources that I am looking at:
Let me know what you think about these references and whether or not they will be appropriate to use to add to this section.  All of these articles are reviews and not primary literature. Immcarle24 (talk) 04:33, 21 February 2016 (UTC)
thread_title:  Expanding on Immune system section 

message: Hello there again! 
Here are some information that I would like to add to this section:
1. Discuss how inflammatory cytokines activate the HPA axis
2. Discuss how the HPA negatively regulates inflammatory cytokines released by immune cells (regulate homeostatic state)
3. What happens when a person is a chronically stress- how does HPA affect immune response?
4. Paradoxical responses of sustained HPA activation- in some studies, HPA activation leads to supression of immune response, while other studies show that chronic HPA activation leads to inflammatory diseases
5. discuss different models that explain these paradoxical results
I won't be adding these 5 points separately in the body of this section.  I will be addressing them all together, but I am not sure how I will do that yet.  I might end up writing 3 paragraphs in total.
Immcarle24 (talk) 04:47, 21 February 2016 (UTC)
thread_title:  Proposed Expansion to Immune System Section 

message: So: a side effect of chronic (and maybe acute?) use of fluocinonide -- a corticosteroid, is HPA axis suppression. A short review of what "HPA axis suppression" actually means, in practical terms, would be nice.  I'm also wondering if topical corticosteroids are best applied in the morning, not the evening, to avoid flattening the diurnal cycle.. !? 67.198.37.16 (talk) 03:27, 17 June 2018 (UTC)
thread_title:  HPA axis suppression and corticosteroids