Talk:Aneuploidy

message: Opening paragraph: "Chromosome abnormalities are detected in 1 of 160 live human births." I can't imagine why this wouldn't need a citation.
137.150.101.98 (talk) 21:35, 3 October 2018 (UTC)
thread_title: Citation Needed

message: There is little more than a dicdef here; I propose moving the Haploidy, Diploidy, Haploidisation, Polyploidy, and Aneuploidy pages to Ploidy.  You have to read all those articles to understand ploidy anywho.  I'll be happy to do the merge after approvial.  Lefty 16:02, 2005 Mar 12 (UTC)
:also Haplodiploidy. Lefty 16:09, 2005 Mar 12 (UTC)
*The rationalistation it should go more like this:
*Ploidy + Haploidy + Haploidisation + Diploidy (regular ploidy)
*Aneuploidy + monosomy + trisomy (abnormal number of chromosomes)
*Polyploidy and its variants (doubling of chromosome numbers) --nixie 22:10, 13 Mar 2005 (UTC)
thread_title: Untitled

message: More specifically, in brains, perhaps in human brains.
*Chromosomal variation in neurons of the developing and adult mammalian nervous system
*Constitutional Aneuploidy in the Normal Human Brain
--Extremophile 23:29, 5 September 2006 (UTC)
replies: text: Discussion added. Medical geneticist (talk) 15:59, 6 October 2008 (UTC)
thread_title:  recent findings suggest that aneuploidy may be more common 

message: It says on this page that trisomy 16 is the most common trisomy in humans. The trisomy 18 page, however, says that it is the second most common trisomy after Down Syndrome (trisomy 21).
Trisomy 16 is the most common at conception, but the fetuses spontaneously abort. Trisomy 21 is the most common in live births, followed by trisomy 18, with 16 way down the list because it's almost always very lethal.
:Discussion fixed. Medical geneticist (talk) 16:01, 6 October 2008 (UTC)
replies: text: Yes, that's accurate. If only some of the cells have an extra chromosome 16, the proportion of the cells that are affected correlates with the severity of the symptoms. If all cells are affected, the condition is lethal before birth and the red colour in the table is appropriate. Sminthopsis84 (talk) 14:45, 10 January 2016 (UTC)
thread_title:  Conflicting Information 

message: This article (and the articles on cancer and carcinogenesis) does not appear to discuss the possible causal role of somatic cell aneuploidy in cancer. There's increasing speculation that a key step in the development of full-blown cancer is a chromosomal abnormality in a somatic cell, particularly if it produces chromosomal instability. It is noteworthy that every one of the heritable chromosomal instability disorders linked from that article is associated with elevated cancer risk and cancer in youth. —The preceding unsigned comment was added by 74.104.131.76 (talk) 22:46, 28 April 2007 (UTC)
replies: text: Discussion added. Medical geneticist (talk) 16:05, 6 October 2008 (UTC)
thread_title:  Various 

message: I don't think that Cri du Chat and 1p36 deletion should be in this article.  Aneuploidy is defined as "having or being a chromosome number that is not an exact multiple of the usually haploid number" (http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=aneuploidy).  Deletions are not numerical but structural changes.  While they can result in "partial monosomy", they are not generally thought of as aneuploid.  I think these should be moved to a separate article on structural chromosome changes or chromosome microdeletions, if one exists.Kxw1 (talk) 19:43, 19 December 2007 (UTC)
replies: text: See the Deletion (genetics) article. Avb 18:39, 20 December 2007 (UTC)
replies: text: I added a small section on "Partial aneuploidy" to make this distinction. Medical geneticist (talk) 16:36, 6 October 2008 (UTC)
thread_title:  Deletions are not considered aneuploidy 

message: This is a pretty good treatment of aneuploidy in humans, but that's a very limited view of the topic.  I'd like to work on getting some information on other species in here.  For now, perhaps the best way to do this without disrupting the organization of the page is to simply add a section on "aneuploidy in other organisms"?  Agathman (talk) 17:51, 26 May 2009 (UTC)
replies: text: I think there's been some expansion of this in the ploidy article.  Not sure if you mean something different.  Are there pathogenic situations with aneuploidy in other species? --- Medical geneticist (talk) 23:35, 26 May 2009 (UTC)
replies: text: Yes, and not only pathogenic ones.  Many plant species produce aneuploids with relatively little loss of viability, for instance.  Aneuploids have a long history of use in genetic research in plants, as a means of locating genes on chromosomes.  Inheritance of a gene on a monosomic or trisomic chromosome is different from the inheritance of genes on the normal disomics, so you can tell what genes are on what chromosome.  The technique was used extensively in cotton and corn, among others, and contributed to the genetic maps that are now used in assembling genomic sequence data.  For that matter, much of what we know about aneuploidy came originally from studies on Datura (Jimson weed).  As for animals, Down syndrome is known in chimps -- it's trisomy of the homolog of human chromosome 21, and I imagine there are other examples -- my expertise is more in plants. Agathman (talk) 00:41, 27 May 2009 (UTC)
thread_title:  Other organisms? 

message: It's always been my understanding that multiple sex chromosomes (especially multiple X's) causes mental/cognitive underdevelopment. Has anyone any idea why this might be? Chbse 12:37, 19 June 2010 (UTC)
replies: text: The process of X-inactivation is thought to be the mechanism for dosage compensation between males and females.  However, there are genes such as those in the pseudoautosomal region that escape X-inactivation (and are thus expressed twice as much in females than in males).  The current theory is that overexpression of these genes might be involved in the developmental delay sometimes seen in individuals with multiple X chromosomes.  In general, the more X chromosomes present, the more likely the individual will have cognitive impairment.  However, it should be recognized that there could be significant ascertainment bias in that these conditions were first recognized in people who were institutionalized and therefore more severely affected. --- Medical geneticist (talk) 00:54, 19 July 2011 (UTC)
thread_title:  Multiple sex chromosomes; polyploidy 

message: Substituted at 07:47, 29 April 2016 (UTC)
thread_title: Assessment comment

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thread_title:  External links modified 

message: This section appears to be referenced well and described neutrally. However, as a layman, I'm concerned that "exposure" is used throughout the text in a vague qualitative way. Can someone insert exposure LEVELS noted in the various articles cited? Martindo (talk) 00:42, 31 May 2020 (UTC)
thread_title:  Aneuploidogen exposure levels 

message: I think it's a polysomy with respect to Y, not a normal state. Alfa-ketosav (talk) 16:10, 21 January 2021 (UTC)
thread_title:  About XYY