Talk:Werner syndrome

message: Comments from Akhan50699:
*The information in the "Characteristics" section (just before the "Diagnosis and Clinical symptoms" part) has a lot of information in common with the "Diagnosis and Clinical symptoms" part, so you might consider combining those sections, or deleting repeated information. 
* Inmy opinion, it makes more chronological sense to put the "History" section first, before the "Characteristics" section, so you might consider moving it up. Done
*It might be interesting to add some information in the History section about how Otto Werner discovered Werner Syndrome. Done
*Expand the two-sentence paragraph at the end of the "causes section," or combine it with a previous paragraph because it seems to be randomly placed there.  
*Expand "Treatment" section if possible--what other treatments are there aside from Vitamin C? Done
*Is the "Popular Culture" section necessary? The instances of Werner Syndrome in these examples of culture seem rather vague--many people may not be familiar with these cultural references. 
::The "popular culture" section should not be deleted. Although references are often obscure, this is a standard section in many medical articles. Biolprof (talk) 04:23, 13 April 2014 (UTC)
thread_title: Untitled

message: This source has a lot of information that could be used in expanding the History section http://sageke.sciencemag.org/cgi/content/full/2002/13/re2 RegOH (talk) 00:44, 11 April 2014 (UTC)
thread_title: History

message: This article is being reviewed as a part of this project
A lot of the stuff I edited/am suggesting is grammatical/syntax-related. The content, overall is fine, I just have some suggestions on how to better word it.
===Lead===
*Third paragraph: "there have been 1,300 reported cases." - Does this mean there have been only 1,300 reported cases ever? Within the last 50 years? Maybe i'm just overthinking this but I think this could be better clarified.
**This was written by someone else, but I reviewed their source and it seems as though there have been only 1,300 cases of Werner Syndrome reported in the literature as of 2006 (when the source was published). I will add this clarification to the lead. Emileemagnusen (talk) 15:51, 8 May 2014 (UTC)
thread_title:  Comments from Estephe9 

message: *Third paragraph: "there have been 1,300 reported cases." - Does this mean there have been only 1,300 reported cases ever? Within the last 50 years? Maybe i'm just overthinking this but I think this could be better clarified.
**This was written by someone else, but I reviewed their source and it seems as though there have been only 1,300 cases of Werner Syndrome reported in the literature as of 2006 (when the source was published). I will add this clarification to the lead. Emileemagnusen (talk) 15:51, 8 May 2014 (UTC)
thread_title: Lead

message: *I split the first paragraph into two because it was long and seemed disjoint.
**I think you could either take out some of the information about the coining of the term "Werner Syndrome" and the disease's link to cancer, or even better, rearrange that information into another portion of this section
*** I liked the sentence about coining the term; could go either way on the cancer sentence. Biolprof (talk) 16:22, 27 April 2014 (UTC)
thread_title: Background and History

message: *I feel as though your first sentence is unnecessary; I think that if you just list the phenotypic symptoms of the syndrome, people will be able to infer that patents' appearances are "abnormal."
**Fixed Emileemagnusen (talk) 15:19, 8 May 2014 (UTC)
thread_title: Characteristics

message: *This could be combined with characteristics — it seems a bit repetitive. 
*In the first paragraph, you both begin and conclude by saying that graying and loss of hair is the most common symptom (repetitive)
**Will restructure to make it less repetitive Emileemagnusen (talk) 15:26, 8 May 2014 (UTC)
thread_title: Diagnosis and Clinical Symptoms

message: *Give a definition or add a link to "eponymous gene."
**Removed the word "eponymous" because it was unnecessary. Emileemagnusen (talk) 15:47, 8 May 2014 (UTC)
thread_title: Causes

message: *Add link to skin graft?
**Done. Emileemagnusen (talk) 15:57, 8 May 2014 (UTC)
thread_title: Treatment

message: *In the first paragraph of treatment, "Like other progeria diseases, there is no cure for Werner's Syndrome." and "Diabetes, cancer, and cataracts are controlled much in the same way as normal cases." are both very similar sentences to the original source.  You might want to rephrase them.
**Done, thank you.   — Preceding unsigned comment added by RegOH (talk • contribs) 14:36, 10 May 2014 (UTC)
thread_title:  Comments from Mjurgens369 

message: This article is being reviewed for this class.
* Correct the error in the first in-line citation. This appears to be the page number in the cited book and should be inside the citation. If you are not sure how to correct this, check WP:Citation tools or post the question at the Teahouse. Also, the citation is missing a space between the year and the book title.
**done, thanks. RegOH (talk) 15:02, 10 May 2014 (UTC)
thread_title:  Comments from [[User:Biolprof|Biolprof]]  

message: *I would add more wikilinks. I came up with a quick list just jotting down while reading: cancer, ophthalmologist, some big names in the history section, autosomal, recessive. I'm sure that there are more you could add though.
*WRN and chromosome 8 were wikilinked later in the article after they had already been previously mentioned.
*Under Associated Diseases, should it be "myelodysplatic syndrome (MDS)" instead of the acronym and name parenthetically? I'm not sure what the English/Wikipedia rules on this are, just a suggestion.  
Ecapelle (talk) 23:36, 9 May 2014 (UTC)
thread_title: Comments from [[User: Ecapelle]]

message: *This article definitely has enough information to not be considered start class, so you might think about changing the class to whatever you see fit, C-class at least.
*Some paragraphs in the article are very long and do not provide for good reading, you might want to consider shortening them or separating them into more, smaller paragraphs.
*wikilinks can be added to later paragraphs in the article
*a picture of the physical appearence of a person with this syndrome would very much improve this artcle
Jfriend2 (talk) 18:05, 10 May 2014 (UTC)
thread_title:  Comments from [[User: Jfriend2]] 

message: *Could you add pictures of an individual with Werner syndrome?
*You might want to provide a link to the p38 pathway or an explanation of what that is, because I am unfamiliar with that protein. Is it similar to p53?
Iamwillthinnes (talk) 00:48, 11 May 2014 (UTC)
thread_title:  Comments from iamwillthinnes 

message: *Could you add pictures of an individual with Werner syndrome?
*You might want to provide a link to the p38 pathway or an explanation of what that is, because I am unfamiliar with that protein. Is it similar to p53?
Iamwillthinnes (talk) 00:48, 11 May 2014 (UTC)
thread_title:  Comments from iamwillthinnes 

message: (In all quotes below, emphasis has been added.)
~ The last sentence of Causes is "Surprisingly, complete loss of WRN helicase activity does not cause clinical Werner syndrome." This leaves out an important detail from the source for the sentence: "Recombinant R834C-WRN protein isolated from mammalian cells in culture displays markedly diminished (40- to 50-fold) ATPase and helicase activities, with retention of WRN exonuclease activity."
~ Several sources provided the basis for this background review: "In all examined cases of cells derived from WS patients, however, neither the RNA transcript nor the protein is detectable9,10. Reported missense amino acid substitutions, present as compound heterozygous mutations in a small subset of WS patients11,12,13,14, lead to protein instability and loss- the functional equivalent of null alleles. Thus, the development of WS appears to require the loss of the WRN protein and both of its encoded catalytic activities."
~ And this statement based on their results sharpens it: "...WRN helicase activity alone is not rate limiting for WS pathogenesis, and that clinical WS likely results only when both WRN helicase and exonuclease activities are lacking in patient cells."
~ But the Wikipedia reader only sees a Causes section that emphasizes the importance of helicase activity ("loss of function of these helicases has important implications in the development of Werner syndrome"), only mentions exonuclease activity as an afterthought -- and concludes with a sentence that (based on what's led up to it) could give the very-wrong impression of "Since loss of helicase activity doesn't cause Werner syndrome, then surprisingly something besides WRN must be a factor." I think it's an unintentional result of how the Causes section aggregated over time, but it's led to the last sentence being a functional misrepresentation of the source.
~ My suggestion for a replacement, based on the quotes above: "One study focusing on a variant WRN (R834C) that has almost no helicase activity but retains exonuclease activity, found that people with this variant do not show clinical symptoms of Werner syndrome. The authors suggested that Werner syndrome likely results only when both helicase and exonuclease activities are lost."
~ (I also think it would be good to reduce the undue weight of the preceding verbiage, and to add some of the sources this study cited as a basis for stating that no WS patient has had detectable levels of WRN... but that's just my strong impression, and I would hate to jump in and start mucking around with an article I haven't been involved in. That's a quick route to discord, wasted time, and error.)
Thank you for your time and stewardship, 65.132.12.114 (talk) 05:14, 2 March 2021 (UTC)
thread_title:  Last sentence under Causes may unintentionally give wrong impression