Talk:Melanocyte

message: This article was categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 00:43, 13 January 2009 (UTC)
thread_title:  Article categorization 

message: this article should be translated from the corresponding articles - german or spanish - they contain much more scientific information!
:Actually, this article is wrong. Think about it. If keratinocytes made a chemical upon DNA destruction called "thymidine dinucleotide" which caused the pituitary gland to make a hormone which triggers melanocytes to make melanosomes, releasing them along dendrites where they go to the top layer of the skin... What would stop the hormone from triggering an even tan? Nothing. There's something missing from the equation as it were. Otherwise, tan lines would not exist. And they do!
:You see:
:"Nitric Oxide and cGMP production is required for UVB-induced melanogenesis and that cGMP mediated its melanogenic effects mainly through the activation of cGMP-dependent kinase. " is how a tan is made. In laymen's terms what effectively happens is that UV-B triggers NO production which in turn triggers cGMP production which triggers melanocytes to undergo melanogenesis.--I'll bring the food 07:01, 2 January 2007 (UTC)
replies: text: I partiallly fixed it, but it requires much work, I don't have the time either, what a shame.--I'll bring the food 07:46, 2 January 2007 (UTC)

text: My understanding was the the melanocortins are also produced in both a paracrine and autocrine manner (by keratinocytes and melanocytes respectively) in response to UV. This would explain tan lines. Rockpocket 08:20, 2 January 2007 (UTC)
replies: text: Thank you for your contribution to this discussion. If you have a source for that I'll add it to the article. As it is, more will need to be made of the "melanocortins" term in it.--I'll bring the food (Talk - Contribs - My Watchlist) 13:47, 6 January 2007 (UTC)

text: Sorry, didn't factor the 5 to 10% into calculations. That gives your 1000 to 2000. Not being a biologist, the diagram doesn't make it clear that the melanocytes are only the little dark bits that are separated by lots of other cells. Cheers House of Physics (talk) 21:26, 9 February 2012 (UTC)
thread_title: Other comments

message: Where do melanocytes come from? I've heard they are derived from the neural crest - is this true? 91.84.208.36 (talk) 01:55, 22 February 2010 (UTC)
thread_title:  Embryological derivation 

message: Proposed new section of the Melanocyte article explaining the role of melanocytes in the immune system.
Some reviews providing evidence for this section are:
Gasque, P., and M. C. Jaffar-Bandjee. 2015. "The immunology and inflammatory responses of human melanocytes in infectious diseases."  Journal of Infection 71 (4):413-421. doi: 10.1016/j.jinf.2015.06.006.
Plonka, P. M., T. Passeron, M. Brenner, D. J. Tobin, S. Shibahara, A. Thomas, A. Slominski, A. L. Kadekaro, D. Hershkovitz, E. Peters, J. J. Nordlund, Z. Abdel-Malek, K. Takeda, R. Paus, J. P. Ortonne, V. J. Hearing, and K. U. Schallreuter. 2009. "What are melanocytes really doing all day long…?"  Experimental Dermatology 18 (9):799-819. doi: 10.1111/j.1600-0625.2009.00912.x.
Mackintosh, J. A. 2001. "The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin."  J Theor Biol 211 (2):101-13. doi: 10.1006/jtbi.2001.2331.
Tapia, Cecilia V., Maryanne Falconer, Fabian Tempio, Felipe Falcon, Mercedes Lopez, Marisol Fuentes, Claudio Alburquenque, Jose Amaro, Sergio A. Bucarey, and Anna Di Nardo. 2014. "Melanocytes and melanin represent a first line of innate immunity against Candida albicans."  Medical Mycology 52 (5):445-452. doi: 10.1093/mmy/myu026.
Immcarle69 (talk) 03:03, 30 January 2018 (UTC)
thread_title:  Melanocytes as Immune Cells