lflage/wiki-talks huggingface dataset:
Talk:Outwood Academy Hasland Hall

message: Victuallers 22:41, 21 March 2007 (UTC)

message: I used to vandalise this page, and would often leave very unpleasant, abusive messages. I now realise that what I did was very wrong, and sincerly promise not to vandalise thhis page, nor any other, again. I am sorry.  —Preceding unsigned comment added by 90.219.51.225 (talk) 11:28, 15 February 2010 (UTC)
thread_title: Sorry

message: Due to recent vandalism on this page, this page is now Semi-protected. This will stop unregistered people from vandalising this page again. I have now reverted the vandalism, and reported it in the relevent way.
Thank you, Kiano 20:06, 15 February 2007 (UTC)
thread_title:  Recent Vandalism Of This Page. 

message: I've corrected this info, as it says that all of the classrooms in the new building have interactive whiteboards. Although rooms 26, 27, 28 and 30 have them, room 29 doesn't.
Ted Ted 18:45, 20 February 2007 (UTC)
thread_title:  21st Century - interactive whiteboards 

message: We have had more vandalism to the Hasland Hall Community School page. This time from 3 different IP Addresses. These people probably were (from the comments they left) Hope, Krystal, and Jack J. 
Thank you for your co-operation, if you have any comments please leave them below. Kiano 18:14, 9 March 2007 (UTC)
thread_title:  More Vandalism 

message: It is about time that this page became semi-protected forever. Novalis and I have just spent ages reverting vandalism from an IP address. It is about time that there was a stop to this and I will be telling Wikipedia to protect the page once again. Also, a user called DAHACKER4008 had deleted the External Links, why?! I have just reverted back his changes (sorry about the small mix up with which version to revert!).
Thank you once again for your co-operation and for other Wikipedians helping with restoring the artile, if you have any comments please leave them below. Kiano 19:56, 22 March 2007 (UTC)
thread_title:  Yet Again - More Vandalism 

message: Could someone remove all the external links, as none of the web pages exist any more. I can't edit it becuase someone's loked the page.
81.129.201.10 (talk) 22:13, 20 June 2008 (UTC)
replies: text: Thanks for pointing this out. I have removed the links & corrected the OFSTED link to point to the correct place. Keith D (talk) 09:00, 23 June 2008 (UTC)
thread_title:  Important tidy up.
Talk:Business overhead expense disability insurance

message: I suggest this article be renamed Business overhead expense insurance or BOE insurance, so that it's not confused with business overhead expenses themselves. SueHay 20:06, 15 February 2007 (UTC)
thread_title: Rename?

message: When I cleaned up this article, I removed the following references because they did not add any text to the article. However, they do support the use of business overhead expense disability insurance in the U.S.  --SueHay 00:24, 1 April 2007 (UTC)
thread_title: Unlisted references

message: Please mention all indirect expenses in petroleum industry special in the field area.
Mahmoud Gaber, Egypt
e-mail: Gabermah@yahoo.com  —Preceding unsigned comment added by 41.196.20.72 (talk) 07:54, 18 January 2009 (UTC)
thread_title:  indirect expenses in petroleum intdustry
Talk:Biodistribution

message: OK, have at it. Bring questions here. Cheers, Casliber (talk · contribs) 20:27, 16 September 2008 (UTC)
thread_title:  Interesting article 

message: * http://www.fda.gov/ohrms/dockets/ac/02/briefing/3916B1_02_K-FDA%20%20-%20Biodistribution%20and%20Dosimetry.htm  —Preceding unsigned comment added by Dondevoy01 (talk • contribs) 13:28, 25 September 2008 (UTC)
thread_title:  References
Talk:Biological target

message: The Undruggable protein article stub should be merged into Biological target, as a sub-section within the "Drug targets" section. First, it's awkward to have an article based on a negative concept since it lacks the good context that would be provided by the main concept page. Second, undruggability is not a stable concept, but is more of an opinion or result based on previous and current drug development efforts. Some scientists believe nothing is undruggable (see this interview with Gerard Evan, for example). New techniques can be invented that provide an approach to druggability (see this). So it's better to think in terms of some targets being currently difficult to drug rather than as inherently undruggable. 
Other thoughts: It may be useful to have a category to classify articles about genes/proteins that have so far been difficult to target with drugs, though they would need to be re-classified if/when they become easily druggable. Regarding the article's name, 'Undruggable protein': it's better to think in terms of undruggable targets (not just proteins) in order to include biomolecules such as small RNAs that are difficult to target. SteveChervitzTrutane (talk) 22:03, 15 May 2012 (UTC)
replies: text: As state here, I think druggability is a better destination for the proposed merger. Boghog (talk) 03:33, 16 May 2012 (UTC)
replies: text:  I have been bold and merged undruggable protein into Druggability#Undruggable_targets. Boghog (talk) 10:35, 17 May 2012 (UTC)
thread_title: Merge undruggable protein

message: It would be helpful if noncovalent was defined in the article, rather than having the definition linked. Reebok532 (talk) 15:29, 27 November 2013 (UTC)
replies: text: in this edit.  Cheers.  Boghog (talk) 16:38, 27 November 2013 (UTC)
thread_title:  Definition of noncovalent
Talk:Biometal (biology)

message: Added History of Biometals heading, more sources are needed to clarify certain details. DMinorsGoodluck (talk) 02:25, 11 February 2022 (UTC)
thread_title:  Added History of Biometals 

message: Listed specific metals and their presence in the body, from their uses to their innate nature in life. DMinorsGoodluck (talk) 22:21, 4 April 2022 (UTC)
thread_title:  Added Specialized Biometals in Naturally Occurring Biometals 

message: Removed External Link heading along with the link beneath it due to it being a dead link and replaced it with a See also section in order to go over more complex structures that may not be covered in this article. DMinorsGoodluck (talk) 03:16, 20 April 2022 (UTC)
thread_title:  External Links Removal and Replacement 

message: Ioline is not a metal element. Does Ioline belong to Biometal? 27.247.162.14 (talk) 22:10, 28 July 2022 (UTC)
replies: text: Good point, thanks for catching that. I'll remove it then DMinorsGoodluck (talk) 22:23, 18 September 2022 (UTC)
thread_title:  Iodine 

message: — Assignment last updated by DMinorsGoodluck (talk) 17:02, 11 September 2022 (UTC)
thread_title: Wiki Education assignment: Molecular Genetics

message: Check your zinc homeostasis sentence. Macdonald-ross (talk) 13:01, 14 September 2022 (UTC)
replies: text: I can redo the sentence for better clarity and easier understanding. If that isn't the issue, reply so that I can attempt to fix it. DMinorsGoodluck (talk) 22:25, 18 September 2022 (UTC)
thread_title:  Check
Talk:Computer-implemented inventions under the European Patent Convention

message: Why this article should not be calles "Computer-implemented inventions under the European Patent Convention":
:* All the other wikipedia articles on this topic are called "software patents in <jurisdiction x>"
:* Almost universally, people talk about software patents rather than computer-implemented invention patents.  For example, during the debate about what was (officially) supposed to be known as the CII directive, the name Commission internal market group called it in internal discussions was "the SoftPat directive"; the UK patent office's focus group was called the "Software patent focus group"; and the term "software patent directive" was universally used by politicians and the media.
:* Interestingly, even lobbyists in Brussels supporting wider and more certain patentability now avoid the term "computer implemented invention".  The idea which the term encouraged, that there was a significant difference between a software patent and a computer-implemented invention patent, is now seen as a notable public relations failure; something that particularly encouraged MEPs towards amendments to reduce software patentability.
:* UK judgements don't use the term "computer-implemented inventions" either.  Typically the term used has been "software-related patents". It should be remembered that this article is about the law under the EPC across the whole of Europe, not specially software patents at the EPO.
:* An important topic the article discusses is potential software patents which are not granted.  An important ground for not granting them is if they are "not considered to be inventions".  Renaming the article computer-implemented inventions forecloses that discussion.
:* Finally, for many people "computer implemented invention" is seen as a POV slanted term, a piece of purpose-made Newspeak, precisely because it seems to shut down the Article 52 discussion.   (Some would go further, and identify it as an attempted piece of spin, which failed; and which, like much failed spin, is now seen as an embarassment by both sides).
:* The defining aspect of the potential patents, in regard to the legal questions they raise, is that they relate to software.
Jheald 20:13, 15 February 2007 (UTC)
Talk:Brevetoxin

message: Because acetylcysteine is very reactive with aldehydes to form water soluble compounds and some of the R groups on Brevetoxin are aldehydes I suggest that research be done on the effectiveness of acetylcysteine on decreasing the toxicity of Brevetoxin. Besides improving renal elimination, it might also alter the ability of the toxin to pass the blood brain barrier.
Of course I might be wrong, it would take experimentation to find out.
71.114.183.105 (talk) 06:40, 17 January 2008 (UTC)
thread_title: suggested research topic

message: * http://scholar.google.com/scholar?hl=en&q=brevetoxin+nomenclature&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0 --58.38.42.115 (talk) 07:25, 15 February 2010 (UTC)
thread_title:  Nomenclature? 

message: The two closing sections were interesting additions to the article, and provide a wealth of material for editorial development.  Could someone with an interest in these areas take these long sections to their next stage?  First, each section needs to be condensed. Give the length of the article, there is far too much detail on these subjects, interesting though they are. Second (and not necessarily chronologically second), further sources need to be identified, specifically, secondary sources from review, monograph, and other high quality venues (books, Natural Product Reports, etc.) so that the content from the small set of primary sources currently appearing can be tested for the notability and generality of the content and opinions derived from them. If there are academic readers of this, this end could be achieved via an academic student project executed in sandbox, with placement here after vetting in Talk. In any case, this body of text is a nice starting point for editing, for an individual with interest and some training. Tags are placed to call broader attention to this, to remain until these sections are in proportion to the rest of article, in terms of detail and length.  Cheers.  Le Prof Leprof 7272 (talk) 04:42, 15 July 2014 (UTC)
thread_title:  Nice body of biol text added, now for next step 

message: — Assignment last updated by Sgrimes2021 (talk) 04:22, 13 February 2023 (UTC)
thread_title: Wiki Education assignment: Developmental and Molecular Biology Spring 2023
Talk:Bufotoxin

message: The article starts by saying that bufotoxins are steroid lactones (i.e., bufadienolides), but then counts tryptamine derivatives and other amines (epinephrine, norepinephrine) in as well. A PubMed search seems to support only the first use of the term, but I don't want to delete (more or less) half of the article without further input. --ἀνυπόδητος (talk) 20:21, 11 March 2014 (UTC)
thread_title: Contradiction
Talk:C3 carbon fixation

message: The intro at C4 tells me that there are three mechanisms which to me is a better intro.
C4 carbon fixation is one of three biochemical mechanisms, along with C3 and CAM photosynthesis, functioning in land plants to "fix" carbon dioxide (binding the gaseous molecules to dissolved compounds inside the plant) for sugar production through photosynthesis.
Anybody care to rewrite? 78.146.157.252 (talk) 13:23, 18 July 2009 (UTC)
thread_title:  [[C4]] article has better intro. 

message: I removed the citation need from the paragarph: "C3 plants lose up to 97% of the water..." because the wikipedia article on Photorespiration addresses these things and citations and references can be found there. Linkato1 (talk) 16:20, 28 August 2019 (UTC)
thread_title:   [[Photorespiration]] 
Talk:CAAT box

message: This could certainly be from my sorely incomplete understanding of the topic, but the article on the TATA box states that TATA is ~25 base pairs from the transcription site; this article says the CAAT box is ~70-80 base pairs from the transcription site; but then it goes on to say that the CAAT/GC area is ~150 base pairs from the TATA box (all in the upstream direction).  The math just doesn't seem to work. Glacialfury (talk) 11:36, 29 September 2008 (UTC)
thread_title:  Contradiction in site location 

message: Hi Sfkuo,
Thank you for your addition to this page. Overall it looks good. Please take into account the peer reviews comments above. Additionally, the empty sections are confusing. Will these be filled in? If not it's probably better to delete them. The "Binding" section is also a bit confusing. Maybe take out specific sequences, if possible. Most people reading a Wikipedia article don't care about the sequence, they just want to know what the it does.
Well done! Thank you!
Elizabeth  — Preceding unsigned comment added by ChemStudent24601 (talk • contribs) 14:55, 24 October 2014 (UTC)
thread_title: GSI Comments

message: Good work! As other reviewers, I would suggest deleting the last section with no content there. If you'd like to keep the references there, you can add them as a separate section titled Further Readings like what this page has Ribonuclease_L. 
Thanks for the effort in adding the protein box but I noticed that your figure in the box has been deleted due to lack of copyright statement. If you have got the figure from PDB, you can use it here but you need to acknowledge the image is free of copyright and cite PDB as mentioned by PDB here. Please follow the directions in the video tutorial below to re-upload your image to Wikimedia Commons and link to it. . 
In addition, it would be the best if you can fill in other details of the protein box like how it looks like on this page Ribonuclease_L. 
Hope it helps! Please let me know if you have any questions. ChemLibrarian (talk) 14:13, 27 October 2014 (UTC)
thread_title: Suggestions from ChemLibrarian

message: Thank you for all the suggestions! I will definitely work on 1) filling out the rest of the sections that I had planned originally, 2) working on linking more towards other Wikipedia pages, 3) Taking the specific sequences out of the binding section since this may be confusing and 4) Adding more sources and finding more figures relevant to the topic.  I realize that this template may not be the best option for this page in particular.  Thanks again! 
Sfkuo (talk) 20:02, 1 November 2014 (UTC)
thread_title: Response
Talk:Count Three & Pray

message: Is the album name a reference to the 1955 film? If so what's the significance?
Greg Lovern (talk) 18:06, 3 March 2022 (UTC)
thread_title:  Album Name
Talk:Atrapadas

message: This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage) Earlier text must not be restored, unless it can be verified to be free of infringement. For legal reasons, Wikipedia cannot accept copyrighted text or images borrowed from other web sites or printed material; such additions must be deleted. Contributors may use sources as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously. Moneytrees🌴Talk🌲Help out at CCI!  03:01, 20 April 2020 (UTC)
thread_title:  Possible copyright problem
Talk:CTCF

message: CTCF is now of great importance in cancer research as it has just been shown to shut down angiogenisis at Moffitt Cancer Center
Angiogenisis allows cancer cells to grow their own vascular system, required for continued growth and survival  If this works shows true, CTCF work could result in cancer becoming an easily managed disease.  From Ray Kurzweil's newsletter an excerpt from the article fromo Moffitt Cancer Center:::
Scientists say they now have a better understanding of angiogenesis, or how cancer blood vessels grow and develop, and a possible way to stop that growth, thanks to research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children’s Hospital of Los Angeles. ..............
“At the heart of vascular development is VEGF which, in precise doses, is an important stimulator of normal blood vessel growth,” explained Seto. “However, VEGF — probably the most important stimulator of normal and pathological blood vessel growth — is regulated by a number of factors.”
According to Seto, the study suggests that CTCF can block VEGF from being activated. So targeting CTCF may be an effective way to fine-tune VEGF and control angiogenesis. The potential to manipulate CTCF opens a window to regulate VEGF and subsequently, the potential to manage angiogenesis and cancer.
“The real significance of this work has been apparent in experiments done at the University of Florida and at Harvard University, where our colleagues used mouse models to demonstrate that depletion of CTCF produces excess angiogenesis in animals,” explained Seto. “Like finding a small key piece in a giant puzzle, it’s truly exciting.”
Ref.: Ming Tang, et al., Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation, PNAS, 2011; [DOI: 10.1073/pnas.1104662108]
Link to the story at Moffitt:  http://www.insidemoffitt.com/content.cfm?page_id=392&press_release_id=431  — Preceding unsigned comment added by 71.66.237.28 (talk) 20:52, 30 September 2011 (UTC)
thread_title:  Angiogenesis and CTCF 

message: Concerning this edit, please note that in the previous edit, I have included much of this material in the Discovery and Function sections. Hence re-adding this material is redundant.  Furthermore, I have replaced the in-line author/year citations which are somewhat ambiguous with fully formatted citations that include external PMID and DOI links so that readers may easily find the original publications.   Also per WP:LEAD, the lead section should contain a short summary of what is in the rest of the article.  The added material is too long and detailed for the lead.
And finally what does the following have to do with CTCF?:
Hence I have reverted the re-addition of this redundant and tangental material. Boghog (talk) 04:32, 23 April 2012 (UTC)
thread_title:  Recent edits
Talk:Repressor

message: I added a new image of the lac operon repression mechanism but I could not locate the previous editor to inform them of my changes. Instead I'll post it here and hope they see it.
~YaguchiA
:Hi YaguchiA.  I'm not the one who created the original figure, but I reverted your image because the the promoter region of the lac operon does not contain UP elements.  I recommend that you remove the UP elements and the blue "lollipops" representing the alpha subunit from your image and reinsert the figure.  CatPath (talk) 16:57, 11 October 2012 (UTC)
thread_title: Untitled
Talk:Sukhumi Babushara Airport

message: I think this airport used to be called Sukhumi Dranda Airport in the Soviet days, but is now referred to by the authorities of the Republic of Abkhazia as Sukhum Babushara Airport. What I don't know is whether Dranda and Babushara are two different villages located nearby or whether they are the same village under a different name. Anyone know more about this? sephia karta 20:18, 15 February 2007 (UTC)
replies: text: According to ru:Бабушара (аэропорт) Dranda and Babushara are two different villages located nearby --Ds02006 (talk) 02:41, 15 January 2009 (UTC)
replies: text:  Yes, these are two different villages. The airport itself is in Babushara; Dranda is located nearby and is the biggest village in the vicinity. Alæxis¿question? 06:42, 15 January 2009 (UTC)
replies: text: Thanks for the info! So should we rename the article? sephia karta | di mi 14:05, 17 January 2009 (UTC)
replies: text: I think the renaming will reflect the current name more exact. Ds02006 (talk) 16:54, 17 January 2009 (UTC)
thread_title:  Dranda / Babushara 
Talk:Calf-intestinal alkaline phosphatase

message: As a scientist who has regularly used CIP, I thought I could improve this article. However, all my revisions have immediately been reverted. I'm new to Wikipedia and not sure what I've done wrong. I didn't mean to cause any offense, so would be grateful if it could be explained to me what I should do to edit this page.Jessthecat2610 (talk) 15:27, 29 January 2012 (UTC)
replies: text: What improvement are you trying to make to the article? I notice here that you removed quite a bit of content and all the references. That is why the Bot reverted your edit.--Pontificalibus (talk) 15:40, 29 January 2012 (UTC)
replies: text:  I thought the content was repetitive and unclear and the references not all that useful. I realise now that I shouldn't have taken the references away and see now why it was automatically reverted. However, I then went back to it and wrote some sentences more clearly, added useful wikilinks, more detail and a couple of new references. Then it was immediately reverted back again by DerBorg. I'm not clear if that is a real user or if that is an automatic response.  — Preceding unsigned comment added by Jessthecat2610 (talk • contribs) 22:36, 29 January 2012 (UTC)
replies: text:  DerBorg is a real person, it appears they got a bit carried away after seeing that your initial edits were automatically reverted. I see now you've made further edits without a problem, so please continue to improve the article! --Pontificalibus (talk) 10:32, 30 January 2012 (UTC)
thread_title: Editing this article

message: — Assignment last updated by Bubbstar (talk) 20:11, 15 May 2023 (UTC)
thread_title: Wiki Education assignment: CHEM 378 - Biochemistry Lab - spring 2023
Talk:Carbohydrate catabolism

message: Removed the following sentence which makes no sense (carbohydrates don't have genes!).  If anyone knows what it was trying to say, please fix and reinsert.
The genetic makeup of carbohydrate (s) can be altered with steroids which cause muscle hypertrophy when ingested see Gilbert et al., 1984. 
-- Kw217 (talk) 20:33, 19 April 2011 (UTC)
thread_title: Untitled
Talk:Ernst von Glasersfeld

message: This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage) Earlier text must not be restored, unless it can be verified to be free of infringement. For legal reasons, Wikipedia cannot accept copyrighted text or images borrowed from other web sites or printed material; such additions must be deleted. Contributors may use sources as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously. Justlettersandnumbers (talk) 19:03, 28 April 2014 (UTC)
thread_title:  Possible copyright problem