Talk:Methemoglobinemia

message: Pictures of people infected with the disease would be a nice addition. Maybe just their hands. Randomfrenchie 01:10, 9 February 2007 (UTC)
replies: text: here is a picture that might work:
http://www.healthsystem.virginia.edu/internet/medtox/images/methemoglobinemia.jpg
Patient with Chemical-Induced Methemoglobinemia
1:31, 31 March 2007 —The preceding unsigned comment was added by 128.192.206.19 (talk) 05:31, 31 March 2007 (UTC)
thread_title: Pictures?

message: Official enzyme name: NADH-cytochrome b5 reductase, symbol: CYB5R3 (link to:  http://en.wikipedia.org/wiki/CYB5R3) 
The name Diaphorase was used previously, but it is not consider the official name anymore.  —Preceding unsigned comment added by 134.60.112.134 (talk) 14:40, 15 December 2009 (UTC)
thread_title: Congenital Methemoglobinemia

message: Suggested addition:  A very well-known series of cases was among the Moon Family of Eastern Kentucky/Western Virginia area.  It carried on through several generations, due to a high amount of intermarriage in the area.  This might be an informative addition to the article
: Added, but I saw it was among the Fugate family, per my cited reference. -- Irixman (t) (m) 23:36, 4 June 2006 (UTC)
replies: text: I disagree.  Do not merge this entry with the entry on the Blue Fugates of Appalachia - continue to  provide links and cross-references between the two articles.  The Blue Fugate entry has the potential to be expanded as a family history, with many details outside the scope of a general overview of methemoglobinemia.  See FloraCalifornia's note above for an example.  If more information about the Fugate family is  posted to Wikipedia, it would simply clutter up a combined entry, and result in the entries being split apart anyway.  -- 71.162.11.76 04:30, 23 November 2006 (UTC)

text: I googled 'Blue Fugates' hoping *specifically* to find a Wikipedia entry on them.  Since I wrote the above^^^ comment, you have removed all but the most basic information about the Blue Fugates - now there is NO room for the type of biographical information I was looking for, and the Fugates are reduced to a one-paragraph example of symptoms.  Can you please explain this decision?  -- 71.162.11.76 19:37, 25 November 2006 (UTC)
replies: text: I reverted Blue Fugates back to its state before redirect.  I couldn't find any record of this merger reaching consensus--the only comments on it seem to be the ones above, which go against it.  (I'd second that vote). Torc2 23:09, 5 October 2007 (UTC)
replies: text: I am for a merge because the Methemoglobinemia article has all of the information that this article has.  As for the argument that the addition of more information about the blue fugates would clutter the methemoglobinemia article... no content additions have been made to the blue fugates article since its december 2005 creation... almost two years ago.  I seriously doubt a content addition is coming.  Also, a number of merger attempts have been made and reverted (including my own), demonstrating that support exists for a merger even if not in the form of 'offical' votes on the discussion page. --Nanobri 01:53, 8 October 2007 (UTC)
thread_title: Appalachian Blue People (merger debate)

message: How do you say this word?   or ? --  Denelson83  04:27, 5 April 2007 (UTC)
replies: text: * It's the first one. Chaldor (talk) 19:30, 13 September 2008 (UTC)
thread_title: Pronunciation

message: Kville105125 03:20, 14 October 2007 (UTC)
replies: text: Why?  There hasn't been consensus yet, has there?  Torc2 04:17, 14 October 2007 (UTC)
thread_title: Merged content from Blue Fugates

message: This series edits by an anon IP editor on 21 August would seem to be a copyvio, given the use from nowhere of numbered footnotes (the article does not use the cite.php system, and certainly not from number 24). As such I have removed the material on sight, (as shown below):
It has been reported (Heard & Ashworth 1968 apud Basrani et al. 2007) that, when placed in an aqueous solution, Chlorhexidine Gluconate (antiseptic) slowly hydrolyzes and forms para-chloroaniline (4-Chloroaniline, p-Chloroaniline or PCA) (24). Para-chloroaniline (PCA) has been shown to be toxic (28, 29). As an aromatic amine, the primary toxic effect is methemogloblin formation (28). Toxicological studies in rats and mice have shown that the hemopoietc system is the major target for PCA (28). In 1990, Chhabra et al (28) conducted a 90-day study (with p-chloroaniline) and found that methaemoglobin formation and accompanying haemolytic anaemia, extra-medullary haematopoiesis, and splenomegaly were indicative of erythrocyte toxicity and regenerative anemia.
Basrani BR, Manek S, Sodhi RNS, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod, 33(8): 966 –969, August, 2007. "doi:10.1016/j.joen.2007.04.001"
24. Heard DD, Ashworth RW. The colloidal properties of chlorhexidine and its integration with some macromolecules. J Pharm Pharmac 1968;20;505–12.
28. Chhabra RS, Huff JE, Haseman JK, Elwell MR, Peters AC. Carcinogenicity of p-chloroaniline in rats and mice. Food Chem Toxicol 1991;29:119 –24.
29. Burkhardt-Holm P, Oulmi Y, Schroeder A, Storch V, Braunbeck T. Toxicity of 4-chloraniline in early life stages of Zebrafish (Danio rerio): II. Cytopathology and regeneration of liver and gills after prolonged exposure to waterborne 4 chloraniline. Arch Environ Contam Toxicol 1999;37:85–102.
30. Hazardous Substances Data Bank (HSDB). A database of the National Library of Medicines TOXNET System, http://toxnet. nlm.nih.gov; last accessed Feb 2007.
Could editors with knowledge of the topic consider if the points that the paragraph covers are notable, and if so include in a fresh manner. David Ruben  Talk  01:27, 23 December 2007 (UTC)
thread_title: Removal of probable copyvio material

message: So, I thought the statement at the end of the Treatment section that said "Also vitamin C cures this condition" seemed kind of dubious.  I found vitamine C talked about at http://www.emedicine.com/MED/topic1466.htm and replaced the statement with what it says there.  I don't know how to properly reference the website though.  Can someone help me? Nanobri (talk) 00:08, 23 February 2008 (UTC)
thread_title: Help citing source on vitamin C

message: Why not use a Punnett Square instead of the stick people, especially since you have a red person representing the "blue" person? Pnoble805 (talk) 18:08, 13 March 2010 (UTC)
thread_title:  Punnet Square 

message: Methemoglobin does not have a higher affinity for oxygen than hemoglobin, it does not carry oxygen at all, hence it's blue colour.  —Preceding unsigned comment added by 188.222.176.177 (talk) 20:31, 24 April 2011 (UTC)
thread_title:  Methemoglobin 

message: The intro doesn't do a very good job of explaining what it is.  Especially the sentence: "Methemoglobin is an oxidized form of hemoglobin that has a decreased affinity for oxygen, resulting in an increased affinity of oxygen to other heme sites and overall reduced ability to release oxygen to tissues."  It's not clear why this would result in an increased affinity of oxygen elsewhere, and what it means by other heme sites.
CrocodilesAreForWimps (talk) 14:49, 12 March 2012 (UTC)
thread_title:  Intro unclear 

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thread_title:  External links modified 

message: That looks like the effect ingesting silver has on your skin.  Not related??Longinus876 (talk) 21:06, 17 November 2021 (UTC)
thread_title:  Silver??