Talk:Cephalosporin

message: Hi , i am 6th year medical student and i have problem identifying the proper antibiotic for specific infection according to the causative organism (which is best for gram positive , nigative ...) ... any help ???
: Pick up a copy of the Sanford Guide to Antimicrobial Therapy?  It's a standard resource for such things. http://www.sanfordguide.com/
Anybody got any idea how this antibiotic (Cephalosporin) is related to immunosuppressant?
:No, but there is a immunosuppressant called cyclosporin. Daevatgl 09:56, 25 September 2005 (UTC)
replies: text: Bro 18 years ago, wtf 223.123.0.80 (talk) 07:09, 9 May 2024 (UTC)
thread_title:  Hi 

message: The classes of Cephalosporins are complicated. 
* Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD; beginning at pp83
This article does a superb job of elucidating the structural activity relationships.  It utilizes a different grouping than the traditional generations, that should also be reflected in the article, though the generations should be retained.  Farseer 07:46, 24 December 2005 (UTC)
thread_title: Help needed

message: It may be that classification into generations depends on the spectrum that each member displays.  Given the large variation in member properties, there is an equally large diversity in the antibiotic spectrum.
Then lastly, the antipseudomonal designation seems to change rapidly as resistance develops in use.  Individual members that were considered antipseudomonal a few years ago, are no longer of much use in that regard and in many sources are no longer considered to by antipseudomonal.  
So how should these be designated and grouped?
Farseer 21:20, 19 December 2005 (UTC)
thread_title: Other issues

message: Peptidoglycan is important for the structural integrity of both Gram-positive and Gram-negative bacteria.  The difference in susceptibility of Gram-positive and Gram-negative bacteria to beta-lactam antibiotics is due to the inability of certain beta-lactams to cross the outer membrane of Gram-negative bacteria  and to differences in the peptidoglycan synthesis machinery .  Siegele (talk) 20:27, 9 December 2007 (UTC)
thread_title: Comments on text

message: would be useful - it is in most pharm textbooks.  —Preceding unsigned comment added by 207.151.253.234 (talk) 01:20, 5 November 2008 (UTC)
replies: text: bar chart would be useful to see how much gram + and - coverage there is.  —Preceding unsigned comment added by 163.40.12.37 (talk) 14:17, 11 March 2009 (UTC)

text: IMHO, not useful to show such info, and also WP:NOT#NOTTEXTBOOK - is gram status of usefulness with respect to antibiotic sensitivities (OK helps distinguish one bacteria from another, but not per se which antibiotic to empirically use in a given clinical situation, and anyway, by time have microbiological result also have precise antibiotic sensitivities). See my comment at WT:MED (settling myself up to be ridiculed, or at least educated to the contrary) David Ruben  Talk  01:18, 12 March 2009 (UTC)
thread_title:  please add graph showing generation activity with what organsims 

message: To my knowledge Rocephin is the drug used for IV dosing for Lyme Disease that does not respond to earlier oral dosing.  —Preceding unsigned comment added by 151.191.175.205 (talk) 16:19, 16 September 2009 (UTC)
replies: text: Yes indeed, although it's an off-label use if memory serves. Cefotaxime or benzylpenicillin can be used as well. Fvasconcellos (t·c) 17:05, 16 September 2009 (UTC)
thread_title:  Rocephin for Lyme Disease 

message: The article currently states that Giuseppe Brotzu took cultures of cephalosporium acremonium in 1948 - this is the year that his paper announcing the discovery was published, inside which he gives the date of taking the culture as 1945   http://pacs.unica.it/brotzu/brotzuen.pdf  — Preceding unsigned comment added by 92.235.204.100 (talk) 17:08, 9 June 2011 (UTC)
thread_title:  compound isolation year incorrect 

message: To the best of my knowledge does Cefatrizine belong to the second and not the first generation. Its spectrum includes accordingly many Gram negative bacteria. --MedMan (talk) 17:36, 25 March 2014 (UTC)
thread_title:  A neglectably little issue about Cefatrizine. 

message: I removed mention of "Ceftamere" from the list because I can find no mention of it apart from websites that appear to get their info from this page.  Whether it's a typo or some other type of error, it needs to be confirmed in a reliable source that predates Wikipedia (or is clearly not dependent on the Wikipedia article) before being included in the list.  -- Ed (Edgar181) 17:52, 13 August 2019 (UTC)
thread_title:  Ceftamere 

message: I have drafted a new overview table from the existing one. My work is here: User:Lukelahood/sandbox#Overview_table. I plan on putting it on this article page soon. I believe it is better organized, with the most used medications towards the top, and the experimental ones towards the bottom.
Any objections?
Lukelahood (talk) 20:51, 28 December 2021 (UTC)
thread_title:  New table proposal 

message: The image used for the core structure of cephalosporins is incorrect. The R1 and R2 groups should be switched. I'm not sure how to update the image. Any help would be greatly appreciated! Koneha (talk) 19:19, 18 March 2023 (UTC)
thread_title:  Cephalosporin Core Structure  

message: Hello! I'm not sure what to say here or how to edit, but I thought I would put here that the link for source 19 is faulty. It doesn't load up any relevant info and is an empty search page. 
Thanks! 204.111.224.88 (talk) 01:49, 1 September 2023 (UTC)
thread_title:  Faulty Link