Talk:AMPA receptor

message: While the link refers to an interesting paper involving AMPA receptors (actually not even the actual study, just a commentary), PubMed lists about 5,348 published articles on AMPA receptors. It is unfair to highlight one specific one, especially since it is not of a general article or a review.  Thus I removed the link. Nrets 01:34, 10 August 2005 (UTC)
thread_title: Untitled

message: Hello there.  The entire article refers to the subunits as GRIA1-4.  My knowledge and all references I can find indicate that the subunits are GluR1-4 (Hollmann et al., and many others, 1990) or GluRA-D (Keinänen et al., and marginally fewer others, 1990) while the genes from which they are transcribed/translated are GRIA1-4.  A pubmed search for GluR1 yields 1156 results while a search for GRIA1 in the same place yields 10 results.  Consequently, I've changed it all over to GluR1-4, and put in a bit about the coding genes.  Hope that's ok and that I'm not massively wrong.  I'm currently writing my thesis about the beasts, so if I am, please tell me asap!  HilJackson 15:40, 22 May 2006 (UTC)
thread_title:  Genes vs. Proteins 

message: As everyone agrees that these receptors are tetrameric, and we know that each subunit has a binding site for glutamate, I think it's safest to say that AMPA-receptors have four binding sites. It is probable that the receptor can activate with only a couple of these binding sites occupied. I have changed the article to reflect this. Aplested 02:40, 18 August 2006 (UTC)
thread_title:  Two binding sites? 

message: In reference to the GluR2's rectification properties, it stated that "non-GLuR2 containing AMPAR's stop outward flow of ions once depolarized" and not specifically potassium which is the only ion that would make sense in that context so i changed it to that.  perhaps a bit redundant but informative for those who don't know any better or are unsrue of what they know.  maybe i don't know any better... anyone's thoughts? —The preceding unsigned comment was added by 208.127.12.15 (talk) 01:04, 16 April 2007 (UTC)
thread_title:  inwardly rectifying potassium channels 

message: "The conformation of the subunit protein in the plasma membrane caused controversy for some time. While the amino acid sequence of the subunit indicated that there were four transmembrane domains (parts of the protein that pass through the plasma membrane), proteins interacting with the subunit indicated that the N-terminus was extracellular while the C-terminus was intracellular. If each of the four transmembrane domains went all the way through the plasma membrane, then the two termini would have to be on the same side of the membrane"
No reference.  —Preceding unsigned comment added by 208.54.95.199 (talk) 22:56, 16 March 2008 (UTC)
thread_title:  structure and function needs a reference 

message: There are two errors in the "Synaptic Plasticity" section
*NMDARs can only open when a depolarization from the AMPAR activation leads to repulsion of the Mg2+ cation. They can also open when the membrane is depolarized by the neighbouring regions and/or by pairing with a very strong signal.
*Unlike AMPARs, though, NMDARs are permeable to both Na+ and Ca2+. Though not entirely inaccurate, a better way to phrase it would be Although both AMPARs and NMDARs are permeable to Na+, NMDARs are further permeable to Ca2+, whereas the presence of the GluR2 subunit renders the AMPARs impermeable to Ca2+  —Preceding unsigned comment added by Paskari (talk • contribs) 12:02, 8 July 2008 (UTC)
thread_title:  Synaptic Plasticity 

message: In A 38-amino acid sequence found prior to (i.e., towards the C-terminus of) the 4th membranous domain the use of "prior" is against the convention that proteins start at the N-terminus and end at the C-terminus. So I'm not sure whether the author confused something here. Icek (talk) 20:36, 21 July 2010 (UTC)
thread_title:  Strange wording 

message: The section on the AMPA receptor as a molecular target for epilepsy treatment is well done.  A further look at AMPA receptors as targets as well as a comparison between those receptors and others when dealing with epileptic effects is summarized nicely in this article by Michael A. Rogawski "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117497/" Jhenstro (talk) 02:16, 1 October 2015 (UTC)
thread_title:  AMPA receptors' role in epilepsy 

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thread_title:  External links modified 

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