Talk:Epsin

message: ==Untitled==
Overall, the information is great. The statements not seem to violate and plagiarism from the cited sources and the sources so far add greatly to the article. Below are some suggestions that should improve the quality of the article:
*Sentence structure and style could be tweaked for clarity in all the sections once formatting is completed. 
- Will work on grammar and read closely for style errors 
*The citations for the sources in the first section should follow the sentences individually rather than lumping them all at the end. In line citations follow Wikipedia's Suggested style guidelines. 
- Fixed it! Good point. 
*The introduction seems lengthy. If possible, trim down the introduction and allocate the information into other subsections. 
- Was trimmed down by another Wiki user. 
*Similarly, the "Structure" section could use some formatting since every citation is the same source. 
- Fixed by other Wiki user
*The phrase "It has also been postulated that..." is potentially unnecessary. Rephrase the information or cite a source so as not to violate articles rules about what is factual and what is not entirely supported.
- Fixed by other Wiki User
*Additional links to other wikipedia articles could be added to integrate the article further. Attempt to link each epsin protein to their own individual article (like  epsin-1) should they exist. Schizophrenia, E. Coli, homologue (sp?), and other important topics necessary for the information to be relevant that may not be understood by the user should probably be hyperlinked, without overlinking.
- Thanks for the comments. They were all super helpful. I will work on adding them for our class project. Lnbond92 (talk) 17:22, 28 April 2015 (UTC)
thread_title: Comments From Cdxaam

message: Overall, the information is great. The statements not seem to violate and plagiarism from the cited sources and the sources so far add greatly to the article. Below are some suggestions that should improve the quality of the article:
*Sentence structure and style could be tweaked for clarity in all the sections once formatting is completed. 
- Will work on grammar and read closely for style errors 
*The citations for the sources in the first section should follow the sentences individually rather than lumping them all at the end. In line citations follow Wikipedia's Suggested style guidelines. 
- Fixed it! Good point. 
*The introduction seems lengthy. If possible, trim down the introduction and allocate the information into other subsections. 
- Was trimmed down by another Wiki user. 
*Similarly, the "Structure" section could use some formatting since every citation is the same source. 
- Fixed by other Wiki user
*The phrase "It has also been postulated that..." is potentially unnecessary. Rephrase the information or cite a source so as not to violate articles rules about what is factual and what is not entirely supported.
- Fixed by other Wiki User
*Additional links to other wikipedia articles could be added to integrate the article further. Attempt to link each epsin protein to their own individual article (like  epsin-1) should they exist. Schizophrenia, E. Coli, homologue (sp?), and other important topics necessary for the information to be relevant that may not be understood by the user should probably be hyperlinked, without overlinking.
- Thanks for the comments. They were all super helpful. I will work on adding them for our class project. Lnbond92 (talk) 17:22, 28 April 2015 (UTC)
thread_title: Untitled

message: The article is coming along, but could use more additions to push it into a Good Article category.
*Consider adding pictures, such as membrane blebbing and clathrin-coated vesicles.
- Added a picture of clathrin coated vesicles and a crystal structure of the ENTH domain since all Epsins contain an ENTH domain  — Preceding unsigned comment added by Lnbond92 (talk • contribs) 20:16, 11 May 2015 (UTC)
thread_title: Comments from Cdeclue7

message: The following section may be correct, but the content looks unreadable even for the most of biologists. I actually do not know how to simplify it properly. Maybe it would be better to get without it:
== Epsin1 ==
Epsin 1 is a brain enriched 94 kDa protein that interacts with ubiquitin via its UIM domains, it interacts with the EH domains of Eps15 and Eps15R via its 3 NPF motifs, it interacts with the alpha appendage domains of AP2 adaptors via DPW motifs and it interacts with clathrin via its clathrin terminal domain binding motifs. This same domain has motifs for clathrin interactions. Given the PtdIns(4,5)P2 specificity of epsin1 and epsin2 they are assumed to be plasma membrane adaptors.
== Epsin3 ==
Epsin 3 is almost exclusively localised to migrating keratinocytes in cutaneous wounds.
== EpsinR ==
Epsin 4/EpsinR/enthoprotin/Clint is thought to be involved in the budding of clathrin-coated vesicles from intracellular compartments. It binds to AP1 adaptors rather than AP2.
pubmed
*Kay BK, Yamabhai M, Wendland B, Emr SD. (1999) Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci. 8, 435-8. pubmed
*Itoh T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S, Takenawa T. (2001) Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science. 291, 1047-51. pubmed
*Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT. (2002) Curvature of clathrin-coated pits driven by epsin. Nature 419, 361-6. pubmed
*Stahelin RV, Long F, Peter BJ, Murray D, De Camilli P, McMahon HT, Cho W.(2003) Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. J. Biol. Chem. Aug 278, 28993-9. pubmed
Audriusa 17:17, 8 April 2007 (UTC)
thread_title:  Removed section 

message: Epsin 4/EpsinR/enthoprotin/Clint is thought to be involved in the budding of clathrin-coated vesicles from intracellular compartments. It binds to AP1 adaptors rather than AP2.
pubmed
*Kay BK, Yamabhai M, Wendland B, Emr SD. (1999) Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci. 8, 435-8. pubmed
*Itoh T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S, Takenawa T. (2001) Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science. 291, 1047-51. pubmed
*Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT. (2002) Curvature of clathrin-coated pits driven by epsin. Nature 419, 361-6. pubmed
*Stahelin RV, Long F, Peter BJ, Murray D, De Camilli P, McMahon HT, Cho W.(2003) Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. J. Biol. Chem. Aug 278, 28993-9. pubmed
Audriusa 17:17, 8 April 2007 (UTC)
thread_title:  EpsinR 

message: Hello, I am talking on this page as part of this assignment and here's a link to my sandbox. This page could use more on Epsin's implication in clathrin coated vesicle formation and how that affects signaling events such as developmental and defense in both mammalian and plants.    — Preceding undated comment added 16:35, 11 February 2015 (UTC)
thread_title:  Developmental Biology Project