Talk:Hydroxyzine

message: The summary panel lists a very long half life (20+ hours), while further down the article the half life is listed as about 3 hours. That seems to be cited, but which is correct?!? 76.17.113.99 (talk) 12:13, 22 August 2017 (UTC)
thread_title:  Half Life? 

message: should be mentioned.  — Preceding unsigned comment added by 92.37.96.108 (talk) 09:00, 26 March 2016 (UTC)
thread_title:  QT interval prolongation 

message: “The effect of hydroxyzine has also been tested on the ability of humans in the registration and storage of memory, and was used in comparison with relatively safe drugs, such as hydroxyzine, to illustrate the effects of benzodiazepines, which are thought to have adverse effects on the capacity of memory storage.”
This sentence makes a comparison to hydroxyzine using the drug in question as the comparable, I think it’s just a simple typo. 99.238.210.144 (talk) 16:56, 13 June 2012 (UTC)
thread_title: Illogical comparison

message: This reads like a piece from a drug label insert from the late 1970s.  It seriously underestimates the incidence of major side effects from this drug.  First of all, like many first-generation antihistamines, Hydroxyzine has significant anticholinergic effects.  It is a potent delirogenic drug in the elderly, particularly in the elderly in cognitive decline (suffering from diagnosed, or in many cases undiagnosed, Alzheimer's disease.)  It is not a safe drug for this reason, particularly in combination with opiates in an elderly patient, where the incidence of resulting delirium is very high.  It is no longer given routinely in combination with opiates for this reason.  The discussion of the drug's side effect prpfile (that confusional states only happen in overdoses or very high doses) is just plain inaccurate and misleading.  Whoever wrote this drug review probably didn't have very much experience with it clinically, particularly in a more vulnerable elderly population.  This article has a long way to go (using terminology from the 1970's like psychoneurosis?).  207.180.129.233 (talk) 21:28, 17 February 2010 (UTC)
thread_title: Major Issues

message: The start of this article isn't very readable. Even educated people will have trouble deciphering it. Perhaps that is deliberate, since this drug can be used to treat anxiety disorder, or it could just be badly written. 
Also, could we add a list of medicines containing this drug? So people know this is the drug in say Vistaril, or Hydarax, or whatever. Carl Kenner 10:17, 29 August 2007 (UTC)
thread_title: Readability

message: I removed the GA tag since this article has not formally gone through the GAC process that all articles must go through to reach GA. Editors who contribute significantly to articles cannot determine GA status themselves. Good work on the article, but please nominate it properly to be reviewed by another editor. Let me know if you have any questions. --Nehrams2020 17:28, 13 February 2007 (UTC)
thread_title: GA removed

message: First and foremostly, i refuse to add this information on moral grounds; i found him a morally reprehensible man, and one of the worst human beings to ever live, with general atrocities to humanity that make me feel physically ill. Regardless, my live and let live attitude prevails, and i have no problems with people adding information related to him or other cultural references, with the following proviso; ANY UNREFERENCED INFORMATION WILL BE REMOVED; this will not become an article with a huge list of cultural references with minutial information, such as "X celebrity took hydroxyzine once". James.Spudeman 18:33, 11 March 2007 (UTC)
replies: text: This information does need to be in the L Ron Hubbard article however, due to his staunch opposition to drugs such as these, it is highly relevant to that article. It is however irrelevant to this article. Unfortunately scientologists will always delete anything that doesn't make L Ron Hubbard out to be a saint, so people here should visit that article from time to time to add the fact that he was on this drug. But it is out of place on this page. Carl Kenner 10:05, 29 August 2007 (UTC)
thread_title:  Note to those wishing to add [[L Ron Hubbard]] and "in popular fiction" information to this article 

message: This article holds some useful information, but has major problems in terms of structure, focus and relevance. I've detailed my assessment on each of the good article criteria below.
1. Well written: The first concern I have about this article is its structure. There are two main headings, "Prescription and use" and "clinical description." I'm not sure what they mean - the first seems to contain a mixture of indications and basic research of dubious or unexplianed relevance to the drug's use in humans. The subhead "treatment of learned helplessness" begins by suggesting that hydroxyzine "shown slight possibilities for use in other species, such as dogs." It then goes on to describe, in detail, experiments on learned helplessness in mice, but fails to explain what the significance of these experiments is. If I remember correctly, LH is typically used as a model for depression, yet depression is not mentioned in this section, and I have no idea how this relates to 'use in dogs.'
The structure of the subheads under the second main heading, "Metabolism and pharmacokinetics," "contraindications," and "adverse reactions" are more logical, although each of theses sections still contains a few non-sequitors, e.g. contrasting 'reports of hallucinogenic properties' with 'clinical data trials' which 'have described its overall calming effect on the formatio reticularis.' I have an undergraduate degree in neuroscience, and I have no idea what this is supposed to mean - I can't imagine what someone without a background in neuroscience would make of many of these details.
Overall, I would advise the authors to shorten the article and reorganise its sections using the headings from other GA - rated pharmaceutical articles, such as metformin. I have noticed that a similar structure was used for this article when it was originally nominated, but it has since been changed.
2. Factual accuracy and verifiability:
There are many in-line references, but oddly, the footnotes do not link directly to the online sources. I would combine the three subheadings under "references" into a single footnotes section embedded in the text. Also, as stated above, I question whether some of these sources are properly understood by the author.
3. Broad in its coverage:
In its current form, the article fails to clearly and succinctly describe the mechanism of action and uses of this drug. Instead, it spends way too much time on basic research of questionable relevance.
4. NPOV: I found no NPOV issues with this article.
5. Stability: This may be the root problem with this article - for reasons I am not familiar with, it appears to be a controversial topic, and has been significantly altered since being GA nominated by ErKURITA on 7 March 2007. Many of my concerns are specific to changes made since then, and I would seriously reccommend reverting to the following version, which predates much of the gibberish: Revision as of 06:25, 10 March 2007 by Alison.
6. Images: The article contains appropriate images for the topic.
I feel obligated to review this article in its current form, and by those criteria, it fails. However, it could potentially be GA quality if it were reverted to a previous form (with a few of the minor issues addressed) & remained stable in that form
#: Rustavo 23:31, 14 March 2007 (UTC)
thread_title: Good Article Review

message: :Moved from article by Fvasconcellos 13:28, 24 March 2007 (UTC)
thread_title:  Adverse effects 

message: I am trying to get off oxycontin that I have been on for severe arthritis pain. My doctor perscribed this and clonidine to help with the withdrawls. I am trying to gather information about these before going off cold turkey so if anyone has any experience with this or anything else that may help the withdrawn symptoms please reply. Diannamo (talk) 01:09, 21 April 2008 (UTC)
thread_title:  should I use this to come off oxycontin? 

message: "However, in doses of 50-100mg,it produces a weak to maderate tranquilizing effect, similar to a 15mg of Oxycodone."
Complete bull.  Hydroxyzine doesn't act on u-opioid receptors, and the vast majority of anecdotal subjective information (pretty much the only avaliable information on how recreational drugs feel) indicates that hydroxyzine is not "fun" and does not feel like an opiate or even a GABA agonist (benzodiazepine, barbituate, ethanol, meprobamate, carisoprodol, etc) type downer.  One person's subjective experience with a drug, especially if it's very out of line with the widespread consensus, does not belong in an encyclopedia article (IMO). 72.84.19.19 (talk) 22:52, 23 July 2008 (UTC)
thread_title:  Removed a sentence 

message: Is this article an appropriate place for describing a cocktail of this drug, paracetamol, codeine, antiinflamatories, caffeine, diphenhydramine and caffeine as a common theraputic intervention, all without any supporting references?  —Preceding unsigned comment added by 121.209.49.58 (talk) 12:34, 18 October 2009 (UTC)
thread_title:  Analgesic cocktails 

message: I am unable to locate the referenced publications which state the studies to find that Hydroxyzine can cause Tardive Dyskinesia. The links at the bottom of the article either go to a "Paid service" requiring money (possibly whoever referenced it is getting a referral fee off it) and another link to a blank article on pub med. I have attempted to track down the referenced names but was unable to find these people. There is as of yet no solid evidence that I can find that it causes TD. Please point me in the right direction if I am mistaken.  — Preceding unsigned comment added by 50.47.153.143 (talk) 02:25, 17 June 2011 (UTC)
thread_title:  Tardive Dyskinesia 

message: This article suggests that hydroxyzine is just as effective as benzodiazepines for GAD. Somehow I highly doubt this; can we get more sources than one study?
66.219.8.229 (talk) 06:08, 4 December 2011 (UTC)
thread_title:  Versus benzos 

message: Does anyone know the standard doses, toxic dose, and half life? Trent (talk) 13:25, 6 January 2012 (UTC)
thread_title:  Dosage 

message: This article invokes a bizarre usage of , placed after content which cites references. The intention is quite opaque to me. DavidLeighEllis (talk) 23:11, 15 August 2013 (UTC)
thread_title:  Reading the tea leaves... 

message: Hydroxyzine has XYZ in order. It's the only word in the Scrabble dictionaries that contains -XYZ- in order. However, I don't think it is appropriate to say it is the only word in the English language with this combination, because it can be arrived at by adding (hydr)oxy- to any chemical name starting with Z. There are not many of those, but they do exist, e.g. hydroxyzeaxanthin. I added a bit to the first paragraph about this. Now, it has nothing to do with the chemical, but it seems like a good DYK candidate. "Did you know... that the name of the drug hydroxyzine contains the last three letters of the Latin alphabet, in alphabetical order?" Roches (talk) 00:57, 14 March 2016 (UTC)
replies: text: DYK is only for featuring new or recently expanded articles. This article would have to undergo rapid massive improvements to be eligible. 0x0077BE (talk · contrib) 15:28, 18 March 2016 (UTC)
thread_title:  hydroXYZine 

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thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Hydroxyzine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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*Added archive https://web.archive.org/web/20070703074852/http://www.pfizer.com/pfizer/download/uspi_vistaril.pdf to http://www.pfizer.com/pfizer/download/uspi_vistaril.pdf
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thread_title:  External links modified 

message: I am removing the below phrase from the Medical Uses section of this article for several reasons.
 however there is insufficient evidence to recommend it as a treatment for generalised anxiety disorder due to the high risk of bias in the reviewed studies.
1. The same paragraph states that hydroxyzine IS prescribed to treat generalized anxiety disorder, and there are several other sources in the same article that favorably compare the efficacy of hydroxyzine in treating GAD to that of anxiolytics such as benzodiazepines. Simply googling "hydroxyzine" returns a plethora of reliable sources stating that it is used to treat anxiety, from the FDA to PubMed Health to WebMD to Medscape.
2. Additionally, this seems to be more an issue with the linked study itself. The text of the abstract on which I assume this phrase was based is "Even though more effective than placebo, due to the high risk of bias of the included studies, the small number of studies and the overall small sample size, it is not possible to recommend hydroxyzine as a reliable first‐line treatment in GAD." This seems to be referencing problems with the data available to the author. 
3. Furthermore, the text I am removing seems to be a bit too WP:CLOP for my tastes.
4. Plain bad grammar, two "however"s in one sentence...
5. If someone wants to pick a bone about whether the text removed really meant that hydroxyzine is prescribed primarily for SYMPTOMATIC relief and not long-term treatment, then that needs to be fleshed out a bit more and properly sourced. Maybe someone with more subject matter expertise can weigh in.
If someone wants to put the text back then I'm happy to discuss. Until then, I've got 5 reasons to remove and I'm going to do so. Ikjbagl (talk) 00:36, 24 August 2018 (UTC)
thread_title:  treatment for generalized anxiety disorder 

message: The hydroxyzine molecule is chiral at the tertiary carbon between the two benzene rings of the TCA backbone (I think of it that way, the two benzene rings and there is also an H substituent and an aliphatic 6-membered ring).
Does anyone have any information on the R- and S- isomers of hydroxyzine? Is the pharmaceutical version enantiopure or racemic? Thanks. 170.223.207.38 (talk) 15:35, 21 June 2021 (UTC)
thread_title:  Hydroxyzine is chiral - Any information on stereoisomers? 

message: , you removed the part calling it a non-barbiturate tranquilizer (specifically removing the word "tranquilizer"). Why did you do so? It is frequently referred to as such. Is it that you think the term is outdated? The papers I added as sources are near when it was invented and introduced (aka, some 50 years old) so as to show that it has been referred to as this for some time now. Its chemical classification and action wouldn't have changed since then, but the implication of the word "tranquilizer" very well may have. I don't see any issue with the word though: it does what it a tranquilizer does, and unless you want to use some restrictive definition of tranquilizer that perhaps only includes gabaergic drugs or typical antipsychotics, I think hydroxyzine fits the definition. Kimen8 (talk) 12:04, 27 March 2024 (UTC)
thread_title:  Non-barbiturate Tranquilizer