Talk:Theralizumab

message: Shouldn't there be  a brief mention of the drug trial incident in the opener, seeing as that's why the drug is particularly notable? Amo 18:04, 17 May 2006 (UTC)
replies: text: I agree. Added. Carcharoth 11:12, 23 May 2006 (UTC)
thread_title: Introduction

message: This is terrible:
http://www.mirror.co.uk/news/topstories/tm_objectid=17292803%26method=full%26siteid=94762-name_page.html%22 —Preceding unsigned comment added by 195.70.32.136 (talk • contribs) 
:http://news.bbc.co.uk/1/hi/health/5121824.stm says parts of three fingers - not all his fingers. Secretlondon 18:09, 27 June 2006 (UTC)
thread_title:  "Elephant man" to loose all fingers on hands and feet 

message: Other than direct dosing....
Could a virus or a bacteria be developed to spread this?
I don't want this or even suggest that this be pursued. I don't know enough medical technology to know the implications...
Reminds me of some SCI-FI literature "Andromeda Strain" http://www.crichton-official.com/strain/index.html
and one of Stephen King's book "The Stand" I think...
Signed curious. —Preceding unsigned comment added by 70.29.188.133 (talk • contribs) 
:I'm sure there are more efficent ways to kill people than by inducing a cytokine storm.  Issue here is that everybody knew this drug was likely dangerous but they did the tests quickly, makes you wonder if learning something 'else' about the immune system from the tests wasn't the real goal. —Preceding unsigned comment added by 134.214.102.33 (talk • contribs) 
Its useful as a weapon since a cytokine storm leaves many peeople requiring healthcare.  Americans might, for example, choose to use sucha weapon while fighting an Islamic countr, such as Iran, since producing thousands of cripple soldiers wouldn't have the same religious impact, i.e. no martyers, big visible costs for fighting, etc. —Preceding unsigned comment added by 69.61.125.42 (talk • contribs) 
Conspiracy theories are great fun - if an organisation claims that they were tests for non-lethal weapons or something then we can add that to the article - but quoting them. Ie - "Political party X stated that it believes that the tests were funded by the United Nations secret anti-Christian warfare department [ref]" Secretlondon 18:32, 1 August 2006 (UTC)
replies: text:  Isn't all of this mildly ghoulish? 82.44.64.173
When bacteria are transfected with the genetic sequences for antibody construction (no mean feat, the different chains are coded on separate chunks of disparate chromosomes in their native hosts), bacteria can indeed synthesize these proteins- but their folding and glycosylation mechanisms usually fail to make a functional mammalian-type molecule. NS/0 is a tenable hybridoma parent; CHO is readily transfected and with its mammalian folding and glycosylation propensities is far more likely to produce a functional protein. 70.16.187.30 00:59, 30 August 2007 (UTC)
thread_title:  Could this be misused? In a bigger way? 

message: The dose given to the men, was just 1/500th the dose that exhibited observable effects in Animals. It is an important point to include in the article.
Diamond Dave 14/08/2006 14:05
As has been pointed out before, the dose given to the human volunteers (1/500th of the lowest dose showing effects in animals) contained enough antibody molecules to bind every T cell in the bloodstream ten times over. Neither a mouse nor a monkey is a man; a response (or absence of a response) in animals is no guarantee of the same in humans. 198.140.178.11
Not true - the dose would have activated around 45-80% CD28 occupancy (Waibler). Even so, such large scale activation can have dramatic effects.  — Preceding unsigned comment added by 78.105.76.223 (talk) 23:58, 9 January 2012 (UTC)
thread_title:  Dose 

message: The Expert Scientific Group has issued it's final report.  I'm very much a newbie at the whole wikipedia thing so I'm going to let someone more adept do the page edit.  Information on the report available here:
Of interest is the dificulty involved in simulating the cytokine storm in vitro.
Austringer 17:00, 11 December 2006 (UTC)
thread_title:  ESG's Final Report 

message: A good article has the following attributes.
1. It is well written. 
::Mechanism of action section does not explain what CD28 actually is and would benefit from a one or two sentence lead summarizing the section for non-specialist readers.
2. It is factually accurate and verifiable. 
::Has references, however not all refs are in the same format, but this a minor point.
3. It is broad in its coverage.
::It covers the subject well.
4. It follows the neutral point of view policy. 
::I don't think it is biased either for or against the company.
5. It is stable, i.e. it does not change significantly from day to day and is not the subject of ongoing edit wars. 
::it is stable.
6. It contains images, where possible, to illustrate the topic.
::The image Image:T cell activation.jpg might help improve the "Mechanism of action" section.
:::Actioned —The preceding unsigned comment was added by SeanMack (talk • contribs) 16:18, 2 January 2007 (UTC)
replies: text: I still can't work out from reading the article what CD28 does. Passed the 1 week hold limit so it fails. Sorry.TimVickers 17:34, 2 January 2007 (UTC)
thread_title: GA review

message: Reference 4 is wrong. 
Dr Marelli-Berg works on lymphocyte migration not memory B cells. In the article she states that binding (and stimulation) of CD28 could alter lymphocyte migration so they exit the blood stream and enter the tissues. 
Do you have a reference for the memory B cell theory?82.69.51.149 (talk) 22:01, 20 August 2008 (UTC)
thread_title:  References 

message: The final report by the Expert Scientific Group on Clinical trials was published in November 2006
(http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_063117)
Also See http://www.sciencebase.com/science-blog/critical-trials-tgn1412.html  —Preceding unsigned comment added by 192.211.24.142 (talk) 22:11, 14 September 2009 (UTC)
thread_title:  Update needed 

message: ....but don't see anything wrong with it, in terms of grammar, etc.--LeValley 21:11, 6 March 2010 (UTC)
thread_title:  I came here to copy edit the one marked section 

message: I have just completed my undergraduate dissertation exploring this subject in great detail. I think this article is quite old and needs updating as brand new research has been brought to light, and this disaster can now be explained in three main ways: 1) Treg cell activation protects rodents from a CRS 2) Monkeys do not express CD28 on effector memory cells, hence thye tolerated the drug. 3) Human PBMC cells did not respond in vitro in pre-clinical trials because it was found this year that the TCR whilst doesn't need to be engaged for this reaction, it does need to be signalling in a very small way dubbed 'tonic' signalling.
I cannot be bothered to write an article on TGN1412 and change, add everything I have found out on wiki, but Im happy to send a copy of the 6000 words to the person who wrote this so they can make a 'better' article using latest data. If interested just reply with an email.  —Preceding unsigned comment added by 139.184.30.134 (talk) 17:41, 15 March 2011 (UTC)
replies: text:  "The person who wrote this"? This is Wikipedia, where articles are written and changed by anyone. Few articles have a clear author of most of the content. If you don't like the article as-is -- and are willing to back it up with references -- make the changes yourself. You don't have to (and in fact shouldn't) do it all at once. -- tooki (talk) 12:22, 16 April 2011 (UTC)
thread_title: My Dissertation

message: The same drug (named TAB08) is under phase II clinical trials since January 2014 ( http://theramab.ru/en/news/phase_II ). According wikipedia (see TeGenero), Theramab has acquired the assets of TeGenero.79.43.237.29 (talk) 10:56, 18 September 2014 (UTC)
replies: text: Interesting. here is some of what they've been up to.LeadSongDog come howl! 18:38, 18 September 2014 (UTC)
thread_title:  Update 

message: The chemical/physical properties listed the molecular weight as "~148g/mol" which seems highly improbable given that antibodies generally have a mass in the kilodalton range. I removed that molecular weight but didn't look for the real number.  — Preceding unsigned comment added by 204.28.125.102 (talk) 01:17, 17 February 2017 (UTC)
thread_title:  Molar mass reported incorrectly 

message: I came across this article via this.  I don't understand much of it but it looks relevant and doesn't seem to be already cited.  I'd rather someone more literate in the topic than me decide whether to add it.  173.228.123.166 (talk) 14:45, 1 September 2018 (UTC)
thread_title:  possible additional reference