Talk:CYP2D6

message: I have heard that CYP2D6 is a non-inducible enzyme in human hepatocytes.  This article states otherwise.  Does anyone have any specific references that may indicate one way or the other?
:I've seen some speculation about that too, but here are a few references: ,  -Techelf 11:55, 12 May 2005 (UTC)
thread_title:  Inducible? 

message: This article seems a bit in need of updating to me!  I'm just learning about this stuff, but according to the Genelex website at www.healthanddna.com, there are FOUR types of CYP2D6 metabolizers, not three - the intermediate metabolizer is missing from this article.  In addition, the substrate table is out of date, as it no longer accurately reflects the Flockhart table - for example, on the Flockhart table buproprion is now listed as a strong inhibitor.  Furthermore, CYP2D6 is very important to the metabolism of tamoxifen and that story deserves a paragraph in it's own right.  
However, I'm not a genetecist, just someone who had breast cancer who has been tested for the CYP2D6 metabolism, found to be an intermediate metabolizer, and who is trying to figure out what that means for taking tamoxifen, as there's no sense in taking something I can't metabolize. There are some leads on my cancer blog, www.imaginebrightfutures.wordpress.com, but other than that, I'm still not at the place where I feel comfortable writing this stuff up, I just wanted to note that it needs to be done!
To all who contributed to this article so far, it's a great start!  —Preceding unsigned comment added by Aunt Amanda (talk • contribs) 04:06, 5 January 2008 (UTC)
replies: text: If you look carefully, the article defines an extensive metaboliser as one who has normal or reduced activity. If you're an intermediate metaboliser, I would assume you can metabolize tamoxifen fine. Since tamoxifen is a prodrug and must undergo metabolism before being active, it would be beneficial for a patient taking tamoxifen to be able to metabolize it more readily. A patient taking tamoxifen should avoid taking medications, such as SSRI's, which compete with tamoxifen for CYP2D6 or medications which inhibit CYP2D6 activity. It might also be a good idea for low metabolizers taking tamoxifen to try to induce CYP2D6 activity. With that said, I'm a chemist and not an MD, so don't take my word as medical advice. This isozyme is of particular interest to me. I'll attempt to incorporate your suggestions in any updates I make to the article, however, I think a lot of your questions are answered in the article on tamoxifen. --Jmcclare (talk) 03:44, 10 April 2008 (UTC)
thread_title:  Tamoxifen 

message: I am highly thankfull that there are people that smart to understand the full context of the text written down which is meant as an explenation. But even with my higher education and to my opinion fairly proper knowledge of medication i have a real hard time understanding what the first 15 lines of text are all about, let alone the rest of it.
Is there anyone out there who can explain it in language a 12 year old would understand? Perhaps, i could also get a grasp of what is meant here then too.
I was sent here due to a little in depth information about a drug related to influencing a part of autism. Thanks a lot! Pim 83.81.164.24 (talk) 21:30, 2 October 2010 (UTC)
thread_title:  Gibberish 

message: Revisions by NEMESIS91 on this article look suspicious (the line "Shawn Makuyana expressed the metbolism as a function of drug power {http//:www.uz.ac.zw/biochem{{</ref>pmid=236609}}.", especially when the ref link appears to be broken, and the other wiki page this user has made is for the cited person Shawn Makuyana (which has been nominated for deletion on the grounds of it being about themselves). I would remove the edits here myself, but have no knowledge of this subject so I thought it best to leave it up to those who do. Bananastalktome (talk) 04:19, 11 May 2012 (UTC)
replies: text: Be bold if you see something fishy. -- Richiez (talk) 10:53, 11 May 2012 (UTC)
thread_title:  Suspicious Edit 

message: 91.155.24.127 (talk) 10:53, 20 April 2017 (UTC)
replies: text: Neither UniProt nor HUGO list CYPD2D6 as a synonym of CYP2D6. Hence I think you are right that CYPD2D6 is a (surprisingly common) misspelling. However I am not sure we need to mention this, unless you can find a source that  Boghog (talk) 03:19, 21 April 2017 (UTC)
thread_title:  Is CYP2D6 same ase CYPD2D6? That should be mentioned in the article. 2D6 vs D2D6. 

message: The endogenous cannabinoid anandamide is a substrate for CYP2D6. Source: https://www.ncbi.nlm.nih.gov/pubmed/18698000 Tkadm30 (talk) 15:45, 28 April 2017 (UTC)
thread_title:  Anandamide 

message: Hi there, this page cites this link for Fluvoxamine being a weak CYP2D6 inhibitor meanwhile the page for Fluvoxamine cites this paper (Full text available via scihub.) stating it's a moderate CYP2D6 inhibitor.
Could someone assist in ironing out this discrepancy?
203.54.35.151 (talk) 12:02, 25 December 2020 (UTC)
thread_title:  Contradictory information on the strength of Fluvoxamine's inhibition of CYP2D6 

message: In the info box under molecular function, “oxidoreductase activity” is entered three times with different levels of additional information.  That seems like it was probably an accident.  I suggest that someone who understands this article take a look and fix it. Isomorphic (talk) 12:10, 10 June 2021 (UTC)
thread_title:  Oxidoreductase