Talk:Apolipoprotein E

message: The positions to determine E2/E3/E4 were listed as 112 and 158, but dbSNP had the positions in the reference paper as 130 and 176, I changed the page accordingly, not sure where this discordance came from...  —Preceding unsigned comment added by 140.247.90.36 (talk) 22:21, 21 February 2011 (UTC)
thread_title: SNP Positions

message: - meta-analysis of coronary risk. JFW | T@lk 07:37, 23 September 2007 (UTC)
thread_title:  Cardiac risk 

message: The article states that E2 is associated with hyperlipoproteinemia. According to Stearns & Koelle "Evolution in health and disease" p. 306 "only a small fraction (<5%) of E2 homozygotes develops a rare lipoprotein disorder (type III HLP), which involves elevated plasma cholesterol and TAGs...." --Padder333 (talk) 16:47, 3 March 2010 (UTC)
thread_title:  E2 allele 

message: The statement "Some ApoE4 homozygotes never develop the disease." might be a little misleading.  As I understand it, this population is vanishingly rare among homozygotes who survive to old age.  — Preceding unsigned comment added by 128.163.7.131 (talk) 20:03, 19 July 2012 (UTC)
thread_title: Suggested removals

message: There's a lot of information here:
http://apoe4.info/
But I'm not sure whether it qualifies as sufficiently scientific for inclusion. Can someone more experienced make that call?
Samuel Webster (talk) 10:34, 3 April 2014 (UTC)
replies: text: I'd say so. --76.7.54.71 (talk) 17:29, 10 September 2015 (UTC)
thread_title:  Suggested external link 

message: There is some evidence that statins are protective against dementia. Alzheimers is not listed as a side effect for the two statins I checked. Can the claim that AD is an adverse effect of statins really be supported?BiologicalMe (talk) 15:07, 27 August 2014 (UTC)
replies: text: None of the references supported the claim, and the material was deleted.BiologicalMe (talk) 12:25, 15 September 2014 (UTC)
thread_title:  Statins and Alzheimer disease 

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thread_title:  External links modified 

message: I can't find word WOMEN in Wikipedia article so I suppose sex differences are not discussed.
"Women are more likely to develop AD=Alzheimer disease than men across most ages and APOE genotypes.
Women with the APOE ε3/ε4 genotype are at approximately 4-fold increased risk.
Men with it show little to no increased risk". 
http://www.jneurosci.org/content/32/24/8254
ee1518 (talk) 15:20, 17 November 2017 (UTC)
thread_title:  Women vs. men? 

message: The claim is made in this article (in the disputed section) that APOE ε4 is associated with shortened telomere length or accelerated telomere shortening, and that the shortened telomeres are pathogenic (the article cited is a single study with novel presumptions and findings, and never replicated). This is a highly misleading claim the way it is stated, as it generalizes from very specific issue and population (older women on hormone therapy). You can't take one very narrow unreplicated study and apply it to everyone. If you want to discuss the narrow implications of how hormone therapy might mitigate telomere characteristic, fine. But do it in a separate article, not a general article on APOE. There are many other studies that show that APOE ε4 is associated with longer telomere length, with the longer telomere also being pathogenic, such as this article: Wikgren M, Karlsson T, Nilbrink T, Nordfjäll K, Hultdin J, Sleegers K, Van Broeckhoven C, Nyberg L, Roos G, Nilsson LG, Adolfsson R, Norrback KF. APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory. Neurobiol Aging. 2012 Feb;33(2):335-44. doi: 10.1016/j.neurobiolaging.2010.03.004. Epub 2010 Apr 14. PMID: 20395015.
:First, I would say calm down, and remember WP:Assume good faith. It seems like you're right, and I've updated the article accordingly, and removed the disputed content banner. Please sign your comments in the future. --  SoloBear89 20:24, 29 June 2022 (UTC)
thread_title:  APOE ε4 and telomere length