Talk:Dapsone

message: you haven't very well explained how it helps in bullous skin disorders. please describe the mechinsm. ta.  —Preceding unsigned comment added by 129.215.5.254 (talk) 20:25, 20 May 2009 (UTC)
thread_title: mechanism

message: I have mentioned that Dapsone is used in combination with rifampicin and Clofazimine as part of MDT for leprosy, as it is should never be used as monotherapy, due to wudespread resistance of m.leprae.--WHO Leprosy 15:52, 24 March 2007 (UTC)
thread_title:  Dapsone 

message: This was added, then deleted by KeepBusy:
: Dapsone has profound anti-inflammatory effects, which are the basis for clinical work in Alzheimer disease  http://www.ncbi.nlm.nih.gov/pubmed/11161635   http://www.alzforum.org/dis/tre/drc/detail.asp?id=40 . Dapsone is a potent blocker of myeloperoxidase (many references available)  http://www3.interscience.wiley.com/journal/119522127/  http://cat.inist.fr/?aModele=afficheN&cpsidt=4858960  and MPO inhibition is indeed the mechanism proposed for dapsone's protective effect on nerve tissue.http://www.ncbi.nlm.nih.gov/pubmed/18615706 
Currently, editors of Dapsone have done a very poor job of representing the known mechanisms of dapsone, and my entry was a start.  Dapsone's effects on MPO are profound, well documented for many years (back to 1978 or earlier), un-contested in the literature, and critical to dapsone's actions in treating pemphigus, DH, and other skin diseases, and experimentally in stroke, Alzheimer disease, and COPD. You are encouraged to edit constructively and improve my entries on wikipedia KeepBusy, not vandalize them. Thanks.--Infinitesimus (talk) 18:08, 17 December 2009 (UTC)
thread_title:  Mechanism of Dapsone 

message: Does anyone have any knowledge of the use of Dapsone in treating SLE? I see that one of the citations mentions SLE, but there is no mention of it in the body of this article.Ian Glenn (talk) 22:57, 21 March 2010 (UTC)
thread_title: Systemic Lupus Erythematosus

message: Unlike other articles, the first line (and indeed the whole article) fails to categorize or type the drug.  Compare to "Rifampicin ... is a bactericidal antibiotic drug of the rifamycin group"  or "Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy."  or even "Aspirin ... is a salicylate drug, often used as an analgesic..."
Unfortunately, I don't what this stuff is, and my quick research online was not fruitful.  The article implies it is a dye.  Is there a category there?  It's a sulfone, but that's more just a description of the chemical structure and not a true category, right?  
Maybe this is related to our ignorance of the mechanism.  
Or maybe there is no category or type.  Shouldn't the first line then state that it is a unique or one of a kind drug?  Anyway, somebody who knows could vastly improve the article with just a few minor edits.TjoeC (talk) 18:01, 12 February 2011 (UTC)
replies: text: +1 Riventree (talk) 07:08, 31 May 2018 (UTC)
thread_title:  Type or category? What is this stuff?? 

message: It may be worth moving to newer references following MEDRS where appropriate, and remove the perhaps overreferencing on some statements where a current review article covers it.
Subject to checking by a domain expert the following may be a candidate.
*
review[pt] dapsone on Pubmed gives 697 results.
Similarly the following ref may be appropriate to include
*
RDBrown (talk) 11:32, 31 January 2015 (UTC)
thread_title:  Older references, too many in places 

message: Hello fellow Wikipedians,
I have just added archive links to  on Dapsone. Please take a moment to review my edit. You may add  after the link to keep me from modifying it, if I keep adding bad data, but formatting bugs should be reported instead. Alternatively, you can add  to keep me off the page altogether, but should be used as a last resort. I made the following changes:
*Attempted to fix sourcing for http://www.medscape.com/viewarticle/440403_5
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—cyberbot IITalk to my owner:Online 12:51, 28 March 2016 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified  on Dapsone. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20090212094516/http://www.itg.be:80/itg/DistanceLearning/LectureNotesVandenEndenE/22_Leprosyp14.htm to http://www.itg.be/itg/DistanceLearning/LectureNotesVandenEndenE/22_Leprosyp14.htm
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—InternetArchiveBot (Report bug) 18:49, 6 December 2016 (UTC)
thread_title:  External links modified 

message: Claims to start from 4,4-thiodianiline, but those are nitrate groups not amine groups. The chromium oxidation might (?) convert the amines to nitrates, but it should still show The Right Thing to start with.
Riventree (talk) 07:08, 31 May 2018 (UTC)
thread_title:  Synthesis diagram (historical) seems wrong