Talk:Spike-timing-dependent plasticity

message: Have you seen the article cited on the page? One by Senn, Markram, Tsodyks? Are you sure you know what you are talking about? Out of the three only Markram is wet biologist. The other two are predominantly computer people. --Gene s 09:26, 31 Dec 2004 (UTC)
thread_title: Have

message: the entire introductory paragraph has been copied from answers.com, which I don't have a problem with, except that it is not very easy to read.  I included the section indicating its differences from hebbian theory, but I am not too experienced with this topic. Paskari 18:54, 30 November 2006 (UTC)
replies: text: my bad then since it isn't plagarised, however, I still think it's difficult to read. I will try to clear it up
Kostasl: Hello, I am writing a report related to STPD and I have to say that Markram is not in there, it is considered that Zhang et al. 1998 launched the area by pointing out the critical window. Debanne 1994 linked LTP to LTD which was very important aswell.
Quoting myself: "The connection between LTP (Long term potentiation) and LTD (Long term depot..)was uknown until a later historically important experiment revealed the connection between LTP-LTD and pre-post spike interactions which was conducted by Debanne et al. in 1994 \cite{debanne1994apa}. It showed that the sign of the change in synaptic strength is a function of the relative timing of pre- and postsynaptic action potentials. Detailed studies of this timing dependence using single pre-postsynaptic spikes soon followed that led to spike timing dependent plasticity and they will be introduced after we look at a model that attempted to capture the LTP-LTD curve observations." The model is Bienenstock-Cooper-Munro.
Then follows Zhang on critical window.
 
Computetional Neuroscience is very much related to the biological aspect of things and it is not strictly AI. The experimental observations are used to develop biologicaly feasible models to derive how the real bio-system work. The biological and computation side of neuroscience go hand in hand.
--62.6.161.161 02:29, 20 May 2007 (UTC)
thread_title: Plagirism

message: Obviously this is a very important article, and while a good start it needs improvement. There's a good, but of course much longer and more technical article at Scholarpedia.
In the section "Mechanisms" it's correctly stated that the Ca signal in largest, ON AVERAGE, when the pre-spike suitably precedes the post-spike. However the best results on this (papers by Koester and Sakmann and Nevian and Sakmann) also show that this "supralinear" signal is only about 50-70% bigger (on average) than the signal expected from the linear sum of the pre=alone and post-alone cases. The actual signals, on a trial-to-trial basis, are rather variable, because of various stochastic effects, and so it's not true that there is always a supralinear signal, and never true that it's "large", as the article says in the next sentence. Presumably what's happening is that trial to trial fluctuations are smoothed out by the integrative action of CaMKinase, which acts as a temporary register of the individual calcium pulses.
The spirit of the section is correct, but it's a little bit too sunny: this issue is the crux not only of STDP but probably the whole of learning and intelligence, and it's rather misleading to give the impression that it's been worked out.
The "History" section is not bad, in some ways better than the Scholarpedia article, which mentions the early Levy work, but mispells Steward's name, and does not properly cite their work. 
In the last section, it's suggested that the original Hebb formulation needs "tweaking". But the timing aspect is already implicit in the original version: the only way the pre-spike can cause the post-spike is if it precedes it.  — Preceding unsigned comment added by 24.188.39.29 (talk) 01:10, 10 November 2012 (UTC)
thread_title:  some additional comments 

message: I find it unclear (after only having read the text before the first section) how this article relates to synapses and synaptic plasticity. The article later mentions synapses, but does not mention synaptic plasticity at all. These two terms should be mentioned in the first paragraph, as this article at least seems to (by judging from the name of it) be very closely related to both of them. —Kri (talk) 20:41, 12 February 2014 (UTC)
thread_title:  Connection to synapses and synaptic plasticity? 

message: I do not see the logic for the mechanism of STDP and NMDA receptors. The backpropagating AP from the postsynaptic neuron is facilitating the opening of NMDA receptors as there is release of Glu from the presynapse. But then first activating the postsynaptic and then the presynaptic neuron should facilitate STDP because activation of the postsynaptic neuron causes the backpropagating AP.
But it is vice versa.
Do you see my point?
LuxMaryn (talk) 12:09, 29 May 2016 (UTC)
thread_title:  Mechanisms