Talk:Metandienone

message: "Methandrostenolone does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects." 
Results reported in:<BR>
"Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study" by B. I. Feldkoren and S. Andersson in J Steroid Biochem Mol Biol. (2005) volume 94 pages 481-487. <BR>
seem to suggest that even if methandrostenolone does not have a high affinity for the androgen receptor, it can still have effects of the androgen receptor. --JWSchmidt 14:00, 11 October 2005 (UTC)
replies: text: Too right, it sucks. --90.240.69.136 (talk) 19:51, 11 October 2008 (UTC)
replies: text: Reads like a dodgy advert to me. Testem (talk) 19:17, 15 March 2014 (UTC)
thread_title: Mechanism of action

message: "The 17α-methylation of the steroid does allow it to pass through the liver without being broken down (hence causing the aforementioned damage to the liver) allowing it to be taken orally"
This sentence is mixing together two ideas. The structure of methandrostenolone makes it less rapidly converted to inactive forms than are some other androgens. However, this does not mean that it is not broken down by the liver. The sentence in the article implies that it it because methandrostenolone is not broken down by the liver that it damages the liver. This is very unlikely. Many of the key articles on this chemical were published in German. Maybe someone who can read German and who has access to a research library can sort this out.--JWSchmidt 21:47, 11 October 2005 (UTC)
thread_title: Metabolism

message: The link to Bob Hoffman is not to the right Bob Hoffman.  —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:01, 19 November 2007 (UTC)
thread_title: Allusions to Sports Figures

message: Hi, I am confused by the information contained in the World Anabolic Review that methandrostenolone "was developed in the mid-forties and experimentally used on returning prisoners of war that had been on very low food intakes." Other sources say that it was synthesized as late as in mid 50's in USA. What is true? Centrum99 (talk) 21:56, 20 July 2008 (UTC)
thread_title: The origin of methandrostenolone

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thread_title:  External links modified 

message: In the first paragraph,it says that Dianabol is used for bulking cycles, and then it says that it's used non-medically. Even though dianabol is not used medically for bulking. It's essentially saying by omission that dianabol is used for medical bulking because the sentence right after describes the non-medical use.  — Preceding unsigned comment added by 81.237.198.75 (talk) 10:48, 7 December 2021 (UTC)
thread_title:  First paragraph redundancy 

message: "...is still quite often used because of its affordability and effectiveness for bulking cycles...It is also used non-medically"
"Bulking cycle" definitely sounds like a non-medical use. Are there any medical uses at all now? 83.252.238.152 (talk) 10:29, 12 December 2021 (UTC)
thread_title:  Medical use?