Talk:Causes and origins of Tourette syndrome

message: I have reviewed the 29 October, 2006 nomination for Good Article and have the following feedback before I would recommend this for a good article:
*The pathophysiology paragraph has a duplicated first sentence.  One of them has a citation, the other doesn't.
*The entire pathophysiology section needs to be rewritten in much simpler language to be more understandable.  It reads like a highly technical medical journal.
**Pathophysiology of the brain is a complex subject:  I've wikilinked the terms, but I can't dumb it down; anyone reading about pathophysiology is likely to have an advanced level of involvement with the topic anyway.  Sandy (Talk) 03:47, 20 November 2006 (UTC)
replies: text: Thanks for the input, Neil916, but there's no need to give it time.  As I've explained elsewhere, I did not nominate the article for GA, someone put all the TS daughter articles up for review just as I was traveling and did not have time to finish them, I am the only author, and I don't have time for this polishing/finishing right now.  My preference would be to remove them all from GA, and strike all GA templates from the page:  I'm not a fan of the entire GA process anyway, and would not have submitted these articles:-)  When I have time to polish and finish the article, I will ask for review from the medical project and other copyeditors I know, and not from GA.  I'm sorry you had to go to the trouble; thanks again for the input. I will finish these articles when I have time. Sandy (Talk) 14:12, 18 November 2006 (UTC)
thread_title: GA Review

message: There are several related problems with this article. Most of the references to the genetics refer to CLINICAL studies, and should NOT be used as a basis for discussing cause. The reported incidence of Tourette's is widely variable - indicating a problem with diagnostics and making it futile to discuss "the" pathological mechanism(s) involved. The genetic "basis" for it is becoming LESS clear. No doubt there is a genetic basis; the question is what fraction of the human population is at risk. And we just don't know. We DO know certain genetic signatures are more correlated with the syndrome than others, and that's about it. The number of cases are growing and simple genetic diseases do not do that (on time scales of decades or less). If some children "grow out" of it (what percentage??!) and some do not, if age of onset is highly variable and may be "triggered", then its very unlikely we are looking at the same mechanism. It seems to me that Tourette's is a constellation of symptoms which, so far, it has been useful to treat symptomatically, but which are unlikely to have a single pathological basis. It is safe to say that some families are at higher risk than others, but that is about it, imho. Also, please remove the obfuscatory word "overwhelming" and replace it with referenced statistics 60%?, 80%?, 99%?? what proportion of the cases are (supposedly) "genetic"? (and please use a biochemical/molecular/genetic research paper/review (from THIS century), NOT a clinical review to substantiate your numbers).72.172.11.112 (talk) 20:36, 23 December 2015 (UTC)
thread_title:  Flawed and inconsistent 

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thread_title:  External links modified