Talk:Lysine

message: "As an essential amino acid, lysine is not synthesized in animals,"
except when we goto Dietary sources:
Catfish, channel, farmed, raw: 9.19% of the protein is lysine.[13]
Chicken, roasting, meat and skin, cooked, roasted: 8.11% of the protein is lysine.[14]
Beef, ground, 90% lean/10% fat, cooked: 8.31% of the protein is lysine.[15]
My biology is fuzzy, but aren't those animals? --Jeff  — Preceding unsigned comment added by 199.43.48.131 (talk) 15:58, 23 October 2012 (UTC)
replies: text: Lysine is essential for all vertebrates ( http://jn.nutrition.org/content/137/6/1626S.full ). The examples you mention above are animals which have in turn consumed lysine in their diet. I will add the proper citations and clarifications later. Abergabe (talk) 12:01, 24 February 2015 (UTC)

text: Thanks for the note 71.125.9.209, one of the editors made a typo an year ago. I have corect it back. I'm not sure if "Plant" is correct, as that would mean the whole plant, not just the seeds, the leaves, the roots or whatever, and in that case there is no need for the "in Plant". -- Boris 19:24, 18 September 2006 (UTC)

text: I agree, there are many instances of these Claims.. Perhaps make a new sections entitled Claims for these "home remedy" types of things.  Another example is in there below: "...beneficial for those with herpes simplex infections"  Rage italic 17:38, 12 February 2007 (UTC)
thread_title:  Sources of lysine 

message: This topic needs a comment and link to the topic on Quality Maize.  High lysine
(and tryptophan) corn is an important technological achievement.  —Preceding unsigned comment added by 129.171.150.154 (talk) 19:22, 7 January 2010 (UTC)
thread_title: Maize

message: All I ever read about is how lysine pills protect you from, and help you get over colds and flu faster.  Shocked to find nothing about that here.
W@ntonsoup (talk) 23:00, 3 June 2008 (UTC)
replies: text: Wikipedia doesn't mention these pills because they don't do anything for you.  Lysine pills are like any "dietary supplement" product, just a scam to get your money.
Following that theme, I don't think the reference to Pauling about lysine and
ascorbic acid is useful.  —Preceding unsigned comment added by 129.171.150.154 (talk) 19:18, 7 January 2010 (UTC)
thread_title:  Nothing on the widely-touted immune effects? 

message: See http://pathway.yeastgenome.org/YEAST/new-image?type=PATHWAY&object=LYSINE-AMINOAD-PWY&detail-level=2. Woodlore (talk)  —Preceding undated comment was added at 14:30, 16 February 2009 (UTC)
thread_title:  Nothing on fungal biosynthetic pathway via alpha-aminoadipate? 

message: There are several references to "Helena Kloosterman; USDA National Nutrient Database for Standard Reference. Essential Amino Acids Search, …" that link to a website named "bitter poison" that apparently has nothing to do with the USDA. Either the label or the link is wrong.  —Preceding unsigned comment added by 98.217.172.71 (talk) 12:36, 1 March 2011 (UTC)
replies: text: All refs removed. HK and USDA were the correct sources, but no idea why that info had been copied into 'bitter poison' and then ref'd there. For the moment, no refs at all, but I intend to ref it as one ref to a USDA site. David notMD (talk) 13:07, 12 June 2017 (UTC)
thread_title:  Mislabeled references 

message: The infobox suggests that an alternative name for Lysine is 3,6-Triaminohexanoic acid, but that can't be right can it, since Lysine has only two amino groups. Surely 3,6-diaminohexanoic acid would be right? Francis Davey (talk) 07:35, 9 February 2015 (UTC)
replies: text: The entry for Beta-Lysine suggests this is a beta form of the amino acid and that "di-" is correct. I don't know what the convention is for biochemical infoboxes and therefore don't know whether that is appropriate. Structurally the two amino acids are different (if one is 2 and the other 3 aminated). "tri-" still wrong though surely? Francis Davey (talk) 07:38, 9 February 2015 (UTC)
thread_title:  3,6-Triaminohexanoic acid 

message: Metabolism
Both the Metabolism and Synthesis sections are small but important. Something to mention under Metabolism is the Saccharopine dehydrogenase enzyme and its role in degradation of lysine. Some articles also mentioned that lysine degradative enzymes are not correlated with an animal's diet but saccharopine oxidoreductase is correlated to an animal's diet.
Lysine Supplementation:
 There are also articles published about lysine supplementation and the reduction of cold sore outbreaks and reduction in healing time. Recent research does show some correlation between supplementation and reduction of cold sore outbreaks or healing time (Arzo12 (talk) 23:49, 23 September 2016 (UTC)
thread_title:  Recommendations for Lysine Page 

message: Text revised to statement that it might help (supported by review in supplement industry supported journal) and statement that evidence is not sufficient to support a benefit claim (supported by Cochrane Reviews review). Cochrane considered authoritative. David notMD (talk) 11:38, 12 June 2017 (UTC)
replies: text: Hi, what was your point again? I cannot fully agree with the "Disupted", because several research papers are available which show some evidence despite the unknown correlations, mechanisms, etc. Tankersley writes "...the lack of arginine or histidine, and possibly the presence of lysine, would interfere markedly with virus synthesis", but concludes that "no ready explanation is available for any of these observations". Medlineplus.gov mentions that "Herpes: There is a concern that L-arginine might make herpes worse. There is some evidence that L-arginine is needed for the herpes virus to multiply.", something, unless not reviewed for a while, seems not "disputed". KR  17387349L8764 (talk) 21:54, 27 May 2021 (UTC)
replies: text: Further study by Mailoo et al. conclude that "In the absence of such research, on the balance of possible risk to benefit, clinicians could consider advising patients that there is a theoretical role of lysine supplementation in the prevention of herpes simplex sores but the research evidence is insufficient to back this. Patients with cardiovascular or gallbladder disease should be cautioned and warned of the theoretical risks." KR  17387349L8764 (talk) 21:59, 27 May 2021 (UTC)
thread_title:  Herpes simplex cold sores lit 

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thread_title:  External links modified 

message: In the Disputed Roles section, this reference...  
Milman N, Scheibel J, Jessen O (1980). "Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study". Acta Dermato-Venereologica. 60 (1): 85–7. PMID 6153847
seems to contradict what is written in the Disputed Roles section of this article - if I am reading and understanding them correctly.
"On the whole, lysine prophylaxis had no effect on the recurrence rate of herpes simplex. However, significantly more patients were recurrence-free during lysine than during placebo treatment (p = 0.05), suggesting that certain patients may benefit from prophylactic lysine administration. In the herpes lesions described, lysine had no effect on the rate of healing or on the appearance of the lesions at their worst."
I understand that the reference used mentions that more patients were recurrence-free during treatment with lysine, however, they also mention that lysine had no effect on the rate of healing or on the appearance of the lesions caused by the virus.
:The finding was that lysine had no effect on the course of an outbreak, but decreased the frequency of outbreaks. It's a primary study which would fail WP:MEDRS. Out-of-date reviews suggested that there might have been something to it prior to the introduction of specific antivirals. The latest Cochrane review (2015) found nothing to it for HSV1. AAFP listed lysine as a possible alternate treatment with limited supporting data in 2005, but didn't mention it in 2016. A little more digging might create a good historical context. BiologicalMe (talk) 14:36, 17 July 2018 (UTC)
thread_title:  Reference 80 seems to contradict the text it is attached to 

message: I was reading the articles of other amino acids on wikipedia and they seem to have a separate section for history/naming. However, in this article it is just a paragraph in the introduction? How about adding a history section for this article?66.44.94.193 (talk) 05:30, 10 October 2021 (UTC)
thread_title:  history section for lysine 

message: The JSmol model for zwitterionic lysine is wrong! The molecule should be protonated on the epsilon amino group!  — Preceding unsigned comment added by 37.221.242.34 (talk) 10:52, 16 May 2022 (UTC)
replies: text: @IP user. Please see discussion at WT:WikiProject_Chemistry#JSmol model for zwitterionic lysine is wrong for attempts to reach a consensus on this. Please make comments there, with reliable sources, if you have them. Mike Turnbull (talk) 11:25, 18 May 2022 (UTC)
thread_title:  Wrong 3D model