Talk:Complex partial seizure

message: The entire creativity and epilepsy section is troubling. Paul the Apostle retroactively diagnosed as being creative and epileptic? With no citation? --Markkidd 06:55, 22 May 2006 (UTC)
thread_title: POV

message: I thank the contributors to this article.  I post these suggestions for major revisions in accordance with the recommendation "Before engaging in a major edit, a user should consider discussing proposed changes on the article discussion/talk page".  
Suggested revision:  "It is uncertain if complex partial seizures enhance creativity.  Research studies have generated conflicting results."    
Reason:  The statement "Complex partial seizures experienced in some people may be conducive to enhanced creativity" is an opinion of a newspaper reporter.  The two scientific cited research studies described conflicting results.  The suggested revision reflects a neutral point of view and the information from the cited scientific references.
 
Suggested revision: "A complex partial seizure is an epileptic seizure that is limited to one hemisphere and causes an impairment of awareness or responsiveness."  
Reason:  This is the current recognized definition of a complex partial seizure.  Reference: page 748 in Tresher, William H., and Ronald P. Lesser, chapter 71 of Neurology in Clinical Practice. Vol. 2. 3rd ed. Boston, MA: Butterworth-Heinemann, 2000. 2 vols.
Suggested revision:  "Complex partial seizures are commonly preceded by a seizure aura.  The seizure aura is a simple partial seizure."  
Reason:  There are two auras in neurological disease, migraine aura and seizure aura.  This revision clarifies this distinction.  Also precedes more precisely describes the relationship between complex partial and simple partial seizures.
Suggested revision:  "The seizure aura might occur as a feeling of déjà vu or jamais vu, fear, euphoria or depression, or depersonalization.  The seizure aura might occur as a visual disturbance, such as tunnel vision or a change in the size of objects."  
Reason:  This revision substitutes the subject, seizure aura, in place of the pronoun subject.  The reader might be uncertain if the pronoun referred to the aura or complex partial seizure.  This revision clarifies this distinction.
Suggested revision:  "The person might still be able to perform routine tasks such as walking or shopping, witnesses may not recognize anything is wrong."  
Reason:  This is a grammatical correction that makes "person" the subject of these sentences.
Suggested revision:  "Complex partial seizures might arise from any lobe of the brain.  Complex partial seizures most commonly arise from the medial temporal lobe, particularly the amygdala, hippocampus and parahippocampal gyrus."  
Reason:  This is described on page 1750 of Neurology in Clinical Practice and also peer reviewed emedicine article: http://www.emedicine.com/radio/topic443.htm.   
Suggested revision:  "A common associated brain abnormality is mesial temporal sclerosis.  Mesial temporal sclerosis is a specific pattern of hippocampal neuronal loss accompanied by hippocampal gliosis and atrophy."  
Original statement:  "It is often caused by mesia lesions in the brain, which are essentially a ridge of scar-like tissue."   
Reason for revision:  This is a more precise description of mesial temporal sclerosis.  The reference for this item is the emedicine peer reviewed site: http://www.emedicine.com/radio/topic443.htm.
Suggested revision: "Complex partial seizures occur when excessive and synchronous electrical brain activity causes impaired awareness and responsiveness."  
Original statement:  "Like more generalized epilepsy, complex partial seizures are caused by a misfiring of a synapse in the brain, which causes a “storm like” reaction with bursts of electricity that can result in changes in personality and physicality."      
Reason for revision:  The International League Against Epilepsy (ILAE) is the universally recognized organization that provides definitions for epilepsy terms (http://www.ilae-epilepsy.org/ctf/seizure_frame.html).  The revision more closely corresponds to the ILAE definition of epileptic seizure.  Also, partial seizures are not necessarily like the seizures of generalized epilepsy.  For example, the genetic generalized seizures commonly arise from ion channel abnormalities.  One example of many references: Rhodes TH, Vanoye CG, Ohmori I, Ogiwara I, Yamakawa K, George AL Jr.  Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures.  J Physiol. 2005 Dec 1;569(Pt 2):433-45.  
Original statement:  "A partial (focal) seizure may occur at any age, as a single episode or as a repeated, chronic seizure disorder (epilepsy). They are seen less frequently in children than in adults, but still account for about 45% of pediatric seizure disorders."
Suggestion:  I would suggest deleting the following unless you can cite a reference that gives information about the frequency and age related incidence for complex partial seizures.
 
Thank you for considering these revisions.
TMM53 (talk) 06:55, 8 April 2008 (UTC)
replies: text: Many thanks for this. At a glance, you appear to be on the right track and making good suggestions. This article isn't great so it shouldn't be hard to improve it. I'll try to find some more time later, with suggestions for other sources you may find useful. If you need help formatting citations, etc, give me a shout. Cheers, Colin°Talk 09:54, 8 April 2008 (UTC)
thread_title:  Suggested Major Revision