Talk:Flecainide

message: Some sections of this document are copied word for word from the product monograph which can be found at: http://products3.3m.com/catalog/us/en001/government/innovative_solutions/node_GSYQ1KL450be/root_GS3RBW6QFVgv/vroot_31S2JJ7584ge/gvel_KJ6SPF8WRSgl/theme_us_innovativesolutions_3_0/command_AbcPageHandler/output_html
specifically the clinical indications section. 85% of the clinical indications section is from this work. If the rest of this article is similarly derived then I don't know if much of this article can be salvaged. I'm not experienced enough, nor do I want to bother, to check through this entire article for copyright violations. Could the original author please clarify these concerns. Matt 16:40, 27 Jul 2004 (UTC)
thread_title: Clarification needed on copyright

message: To Matt: OK.  Will do.  These days I am super busy and I will try to work on it in the following 30 days.  Any help from your part will be more than welcome.  One question:  Is the product information/instructions (whatever comes with the physical product) something considered Public Domain or would you consider it copyrighted? --AAAAA 04:09, 28 Jul 2004 (UTC)
thread_title:  Removing copyrighted/reserved materials 

message: I'm hesitant to simply re-revert the article since that doesn't seem to lead anywhere, I'm posting on WP:RFC in hopes that third party intervention will lead to some agreement between AAAAA and myself. Matt 06:45, 30 Aug 2004 (UTC)
thread_title:  Current steps 

message: I took out the part that you consider rewritten without effort.  I was hoping that after some time you would forget about watching this page, but I guess I was wrong.  I give up. --AAAAA 11:30, 30 Aug 2004 (UTC)
thread_title:  Response from AAAA 

message: *Flecainide been posted before, constant revert war going on, see talk page for details. Matt 03:39, 19 Nov 2004 (UTC)
thread_title:  From [[Wikipedia:Copyright problems]] 

message: The statements:
"For the treatment of life-threatening ventricular arrhythmias (ie: ventricular tachycardia), a starting dose of 100 mg twice a day may be appropriate."
and
"Results of a medical study known as the Cardiac Arrhythmia Suppression Trial (CAST) demonstrated that patients with structural heart disease (such as a history of MI (heart attack), or left ventricular dysfunction) and also patients with ventricular arrhythmias, should not take this drug."
seem to contradict eachother.  I take this drug for ventricular tachycardia - am I risking my life or not?  —Preceding unsigned comment added by 66.29.174.66 (talk) 09:19, 3 October 2007 (UTC)
replies: text: I have marked the statement in the lead about using the drug "to treat . . . ventricular tachycardia" as needing a citation and, in the paragraph about the CAST Trial have put a tag requesting further specification of the statement about not using the drug in patients with "patients with ventricular arrhythmias."  74.96.191.182 (talk) 18:31, 25 September 2014 (UTC)
thread_title:  Apparent Contradiction 

message: I have some concerns that the following phrase from the opening paragraphs of this article is oversimple for such a technical article.
"Flecainide works by regulating the flow of sodium in the heart, thus slowing nerve impulses"
Now there are Sodium channels involved in nerve conduction, very similar or identical to those found in the His-Purkinje system and myocardial cells. But to say that Flecainide slows nerve impulses (it may well for all I know!) seems misleading as the depolarisation of myocardial cells and the propogation of electrical activity across the heart does not involve nerve impulses.
Accordingly, I have changed this phrase.
Feel free to comment guys and gals. In the spirit of Wikiquette, feel free to change it back, or indeed to better and please leave me a comment to explain.  —Preceding unsigned comment added by 163.160.252.16 (talk) 22:44, 29 January 2008 (UTC)
thread_title:  correction 

message: A book written for laymen about the discovery, testing and use of tambocor:
DEADLY MEDICINE: WHY TENS OF THOUSANDS OF HEART PATIENTS DIED IN AMERICA'S WORST DRUG DISASTER, Thomas Moore, Simon and Schuster, 1995, ISBN-10: 0684804174, ISBN-13: 978-0684804170
Brief summary: antiarrythmics were overprescribed and, TO THE SURPRISE OF THE EXPERTS, resulted in "excess deaths" over what you would expect without treatment. AdderUser (talk) 20:30, 8 December 2011 (UTC)
thread_title:  Book about Tambocor / Flecainide 

message: Substituted at 15:15, 29 April 2016 (UTC)
thread_title: Assessment comment

message: This article refers to cloud on the safety of flecainide created by the CAST trial, as follows:
     "Results of a medical study known as the Cardiac Arrhythmia Suppression Trial (CAST) demonstrated that patients with structural heart disease (such as a history of MI (heart attack), or left ventricular dysfunction) and also patients with ventricular arrhythmias, should not take this drug. The results were so significant that the trial was stopped early and preliminary results were published."
Flecainide use has indeed been reduced by this finding.  However, later metanalysis has found this concern created by the CASET  trial t be substantially overstated, partly because specific subgroups within the CAST trial were the ones most adversely affected. As one example, see Debra S. Echt, MD, & Jeremy N. Ruskin, MD, "Use of Flecainide for the Treatment of Atrial Fibrillation," Am J Cardiology 2020;125:1123−1133.
  This newer analysis should be reflected in the article, which otherwise discourages the use of flecainide in many patients who would appear to benefit from it. 216.166.175.72 (talk) 21:53, 4 September 2023 (UTC)
thread_title:  Article does not reflect later re-analysis of CAST trial's findings.