Talk:Rosiglitazone

message: It might be worthwhile to critique the Nissen study here for its questionable methodology, as well as include more recent study information re increased CV risk. Also, might be worth to mention of Rosiglitazone's effect of LDL metabolism (see Thiazolidinediones review by Hannele Yki-Järvineni, 2004; figure 4). --Xris0 (talk) 18:33, 13 March 2008 (UTC)
thread_title:  Initial comments 

message: A generic version of this drug is available outside of the US. It is manufactured by Cipla Ltd. (India) and is called Senzia. InsultComicDog (talk) 00:54, 4 May 2010 (UTC)
thread_title: Not sure whether it's worth mentioning

message: -- John Broughton   (♫♫) 01:26, 10 July 2010 (UTC)
replies: text: And here from the NYT:  
http://www.nytimes.com/2010/07/10/health/10diabetes.html?src=me&ref=health  Gandydancer (talk) 11:13, 11 July 2010 (UTC)
thread_title:  July 9, 2010 article 

message: They've done an updated meta-analysis. OR was 1.3 for MI but no change in cardiovascular death - http://archinte.ama-assn.org/cgi/content/abstract/170/14/1191. Probably citable after the recent raft of additions. JFW | T@lk 10:39, 27 July 2010 (UTC)
thread_title:  Nissen/Wolski 

message: I deleted the following unsourced sentence from the Controversy and response section: "In Nov 2011, in a unique case, all sales of rosiglitazone were directed by the U.S. Department of Health and Human Services to go through Liberty Medical in Port St. Lucie, Florida. As a result of this action, the price of the drug immediately more than doubled, and in some cases, increased 250%.[citation needed]."
It may be true that the Centers for Medicare and Medicaid Services, an agency with HHS, has restricted federal reimbursement for the drug and it's possible that the price increased as a result, but an unverified statement to that effect violates Wiki standards. Lahaun (talk) 02:37, 17 March 2013 (UTC)
thread_title:  US Federal restrictions on purchasing 

message: I added an explanation of the 43% statistic reported by Nissen & Wolski, to follow good practice in interpreting effects on the original scale rather than just reporting them on the ratio scale. I also corrected the statement that said N&W found a higher risk of death from CV causes, compared to the risk of heart attack: it was the increase (on the ratio scale) that was higher (1.64 compared to 1.43), rather than the risk itself. Peterwlane (talk) 06:45, 4 June 2013 (UTC)
thread_title:  Quoted statistics 

message: I lack the necessary skills to write up new information - perhaps someone more qualified can update the article?
A recent paper suggests that long term exposure to Rosiglitazone can induce "browning" of white adipose tissue, leading to weight loss.
The reference is: A. Loft, I. Forss, M. S. Siersbaek, S. F. Schmidt, A.-S. B. Larsen, J. G. S. Madsen, D. F. Pisani, R. Nielsen, M. M. Aagaard, A. Mathison, M. J. Neville, R. Urrutia, F. Karpe, E.-Z. Amri, S. Mandrup. Browning of human adipocytes requires KLF11 and reprogramming of PPAR  superenhancers. Genes & Development, 2014; DOI: 10.1101/gad.250829.114
A link is: http://genesdev.cshlp.org/content/early/2014/12/10/gad.250829.114
The abstract says:
Long-term exposure to peroxisome proliferator-activated receptor γ (PPARγ) agonists such as rosiglitazone induces browning of rodent and human adipocytes; however, the transcriptional mechanisms governing this phenotypic switch in adipocytes are largely unknown. Here we show that rosiglitazone-induced browning of human adipocytes activates a comprehensive gene program that leads to increased mitochondrial oxidative capacity. Once induced, this gene program and oxidative capacity are maintained independently of rosiglitazone, suggesting that additional browning factors are activated. Browning triggers reprogramming of PPARγ binding, leading to the formation of PPARγ “superenhancers” that are selective for brown-in-white (brite) adipocytes. These are highly associated with key brite-selective genes. Based on such an association, we identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning, including the increase in mitochondrial oxidative capacity. KLF11 is directly induced by PPARγ and appears to cooperate with PPARγ in a feed-forward manner to activate and maintain the brite-selective gene program.  AncientBrit (talk) 05:48, 19 December 2014 (UTC)
replies: text: Thanks for posting, but we don't add content about health based on animal or in vitro studies - please see WP:MEDRS.  Jytdog (talk) 12:05, 19 December 2014 (UTC)
thread_title:  Treatment of obesity? 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: The book Bad Pharma notes that a large percentage of trials were not published. www.alltrials.net has details. Should Wiki work with Alltrials to point out the suppression of trials and include data on how many trials were unpublished or terminated early if the results would not reflect well. People rely on Wiki for information and we CAN provide more information than the PDF, BNF and similar references used by doctors. It's a big step but if we take it, we will become the BEST source for doctors and patients.  — Preceding unsigned comment added by 81.99.74.135 (talk) 22:55, 1 January 2017 (UTC)
thread_title:  Bad Pharma 

message: I guess that the trials and approvals are all of Rosiglitazone maleate but it would be nice to have the article say for sure. - Rod57 (talk) 12:35, 18 August 2017 (UTC)
thread_title:  Is this article only about the maleate form 

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thread_title:  External links modified 

message: Seriously, you're going to write this whole article on something essentially called 'rosy glitter zone' and never say a word about etymology?  What is it supposed to mean?  Correctrix (talk) 04:09, 23 October 2017 (UTC)
replies: text: The "-glitazone" part means it is a peroxisome proliferator activating receptor-γ (PPAR-γ) agonist and thiazolidinedione derivative per the INN.  Not sure where the Rosi- comes from.  Thiazolidinedione is linked in the first sentence and if you look at that article you can see other members of the class, named with the same suffix.  Most drug names are goofy this way.  But this is really reference desk stuff.  Jytdog (talk) 04:33, 23 October 2017 (UTC)
thread_title:  Name