Talk:Krabbe disease

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I'd like to propose the "Incidence" section be modified. The 1/100,000 incidence estimate can be attributed to the book chapter by Wenger et al. ("Galactosylceramide lipidosis: globoid cell leukodystrophy (Krabbe disease)", in The metabolic and molecular bases of inherited disease, 8th Ed., 2001, Scriver, Beaudet, Sly, Valle, Eds.), but since the units of this estimate is not cases per person-years at risk, it can not be an incidence measure. The authors provide no indication as to how the 1/100,000 statistic was calculated, and furthermore, the lead author (DA Wenger) no longer describes this 1/100,000 estimate as "incidence" in his latest chapter on Krabbe disease ("Krabbe Disease (Globoid Cell Leukodystrophy)", in Leukodystrophies, 2011, Raymond, Eichler, Fatemi, Naidu, Eds.). I propose that this statistic be removed, and replaced with estimates of birth prevalence from some (or all) of 7 epidemiology papers whose bibliographic information I will provide below. The section header will need to be changed from "Incidence" to "Epidemiology." I propose a sentence along the lines of:
 "The birth prevalence of Krabbe disease is estimated to be in the range between
 0.29 to 1.35 per 100,000 births (refs)"
Poupetova, Ledvinova, Berna, et al. 2010. The birth prevalence of lysosomal storage disorders in the Czech Republic: comparison with data in different populations	J Inherit Metab Dis 33(4): 387-396
Ozkara & Topcu 2004. Sphingolipidoses in Turkey	Brain and Development 26(6): 363-366
Poorthuis, Wevers, Kleijer, et al. 1999. The frequency of lysosomal storage diseases in The Netherlands	Hum Genet 105: 151-156
Applegarth, Toone, & Lowry 2000. Incidence of Inborn Errors of Metabolism in British Columbia, 1969-1996	Pediatrics 105(1)
Meikle, Hopwood, Clague et al.	1999. Prevalence of Lysosomal Storage Disorders	JAMA 281(3): 249-254
Pinto, Caseiro, Lemos, et al. 2004. Prevalence of lysosomal storage diseases in Portugal	Eur J Hum Genet 12: 87-92
Heim, Claussen, Hoffmann, et al. 1997. Leukodystrophy Incidence in Germany	Am J Med Genet 71: 475-478
--Afossbio (talk) 16:51, 21 June 2011 (UTC)
thread_title:  Questions about Incidence section

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I have just modified one external link on Krabbe disease. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20110720092707/http://nfrd.unc.edu/krabbe-pep.cfm to http://nfrd.unc.edu/krabbe-pep.cfm
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Cheers.—InternetArchiveBot (Report bug) 17:26, 12 December 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified one external link on Krabbe disease. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20110720092728/http://nfrd.unc.edu/research/krabbe.cfm to http://nfrd.unc.edu/research/krabbe.cfm
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Cheers.—InternetArchiveBot (Report bug) 00:19, 27 December 2017 (UTC)
thread_title:  External links modified