Talk:MeNZB

message: Ěthis was an effective immunisation :]  
::yeah it really was.
:::har har. 
219.89.103.84 02:51, 2 September 2007 (UTC)

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thread_title:  External links modified (January 2018) 

message: https://en.wikipedia.org/wiki/Gonorrhea
https://en.wikipedia.org/wiki/MeNZB
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https://pubmed.ncbi.nlm.nih.gov/29048985/
2018 May 4
The recent discovery that meningococcal group B OMVs may protect against the related Neisseria species N.gonorrhoeae. 
There are 2 OMV-containing group B vaccines available, 
the new recombinant protein-based Bexsero® developed by Novartis 
and VA-MENGOC-BC® developed by the Finlay institute in Cuba. 
Also, a third group B vaccine based on two recombinant factor H binding proteins (Trumenba®, Pfizer), has recently been licenced but it does not include OMV. 
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https://www.immunize.org/askexperts/experts_meningococcal_b.asp#recommendations
* Available data indicate that protective antibody levels wane in most recipients within 1–2 years of completion of the primary series.
* Bexsero (MenB-4C, GSK) is a 2-dose series with doses given at least 1 month apart.
* Evidence to date suggests no impact of MenB vaccine on meningococcal B carriage (may protect an individual from invasive disease but is unlikely to impact transmission of the bacteria to others)
* Approved ages 10–25 years in USA.
In Finland approved for all ages including >50 years:
https://laakeinfo.fi/Medicine.aspx?m=17572&i=GLAXOSMITHKLINE_BEXSERO
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https://www.nature.com/articles/s41541-021-00388-3
Title: Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect
29 October 2021
Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization.
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https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00812-4/fulltext
Title: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study
April 12, 2022
Complete MenB-4C vaccination series was 40% (95% CI 23–53) effective against gonorrhoea and partial MenB-4C vaccination series was 26% (12–37) effective.
Complete vaccination = two MenB-4C doses administered 30–180 days apart.
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https://reference.medscape.com/drug/trumenba-bexsero-meningococcal-group-B-vaccine-999974
Bexsero.
0.5 mL IM as a 2-dose series administered at least 1 month apart
ACIP recommendations for at risk adults
Booster dose: Administer 1 year after primary series completed and repeat booster dose every 2-3 yr if risk remains
At risk individuals include e.g. 
Microbiologists routinely exposed to Neisseria meningitidis
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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https://gskpro.com/en-gb/products/bexsero/real-world-evidence/
Study design: 3-year observational study
Bexsero was introduced for all infants in the UK in September 2015.
Infants were administered the vaccine at 2, 4 and 12 months, which resulted in a 75% reduction in meningitis B incidence in all fully eligible children in England. 
incidence rate ratio, 0.25; 95% CI, 0.19 to 0.36).
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https://www.medicines.org.uk/emc/product/5168
Intervals between Primary Doses:
Not less than 1 month or 2 months, depending on age.
There are no data in adults above 50 years of age.
91.159.188.253 (talk) 22:29, 15 June 2022 (UTC)
thread_title:  Bexsero (= 4CMenB = MenB-4C) protects from Gonorrhea