Talk:Regulatory T cell

message: ==Wiki Education Foundation-supported course assignment==
 This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immacarle14. Peer reviewers: Immcarle15.
==Untitled==
This is a really neat article, but we need some references...PLEASE! doctorwolfie (talk) 15:40, 6 June 2012 (UTC)
thread_title: Need References

message: This is a really neat article, but we need some references...PLEASE! doctorwolfie (talk) 15:40, 6 June 2012 (UTC)
thread_title: Untitled

message: This is an addition for the functions section. It describes what is known about cross regulation between CD4+ T helper cells and CD8+ T suppressor cells from human subjects with a history of infection with Leishmania chagasi. I think it is particulary current given recent findings about the role of CD8+ T suppressor cells in diseases other than leishmaniasis. Putative cytokines secreted by leishmania specific CD4+ T helper cells have been shown to inhibit and kill CD8+ T suppressor cells but not CD4+ T helper cells. These soluble factors have not yet been isolated or identified. This is my first time contributing to Wikipedia.
Studies of human subjects with a history of leishmania infection suggest that modulation of CD8+ suppressor T cells is, at least partly, mediated by cytokines. Leishmania specific CD4+ helper T cells predominate in adults with strong protective immunity (skin-test positive with no history of clinical infection). When added to autologous leishmania infected macrophages these T cells cause parasite death and secretion of large amounts of interferon-gamma and lymphotoxin. CD8+ T suppressor cells predominate in patients with no protective immunity (visceral leishmaniasis patients). When added to autologous peripheral blood mononuclear cells isolated after successful treatment, these T cells inhibit interferon-gamma secretion and proliferation and increase interleukin-6 and interleukin-10 secretion. A soluble factor(s) generated by antigen or phytohemagglutinin stimulation of leishmania-specific CD4+ helper T cells from skin-test positive adults killed CD8+ T cells but not CD4+ helper T cells when added to culture media. Soluble factors generated by antigen stimulation of peripheral blood mononuclear cells from skin-test positive adults prevented CD8+ suppressor T cell mediated increases in interleukin-10 secretion. These findings suggest that antigen stimulation of CD4+ helper T cells results in production of cytokines that kill or down regulate CD8+ T suppressor cells. Once the leishmania infection has been eliminated and leishmania antigens are gone, CD8+ T suppressor cells down-regulate CD4+ T helper cells. Isolation of cytokines that inhibit and kill CD8+ T suppressor cells might be useful in treating diseases that involve immune suppression such as leishmaniasis, AIDS, and certain cancers.
  
References
Holaday B, Pompeu M, Jeronimo S, Texeira M, Sousa A, Vasconcelos W, Pearson R, Abrams J, Locksley R (1993). “Potential Role for Interleukin-10 in Immunosuppression Associated with Kala Azar”. Journal of Clinical Investigation 92: 2626-2632. 
Holaday B (1999). “Immunotherapy for Visceral Leishm,aniasis: Ability of Factors Produced during Anti_leishmania Responses of Skin Test Positive Adults to Inhibit Peripheral Blood Mononuclear Cell Activities Associated with Visceral Leishmaniasis”. Memorias do Instituto Oswaldo Cruz 94: 55-66. PMID: 10029912
Holaday B, Pompeu M, Jeronimo S, Texeira M, Sousa A, Vasconcelos W, Pearson R, Abrams J, Locksley R (1993). “Potential Role for Interleukin-10 in Immunosuppression Associated with Kala Azar”. Journal of Clinical Investigation 92: 2626-2632. 
Holaday B (1999). “Immunotherapy for Visceral Leishm,aniasis: Ability of Factors Produced during Anti_leishmania Responses of Skin Test Positive Adults to Inhibit Peripheral Blood Mononuclear Cell Activities Associated with Visceral Leishmaniasis”. Memorias do Instituto Oswaldo Cruz 94: 55-66. PMID: 10029912BettieHoladay (talk) 22:26, 11 July 2011 (UTC)
thread_title: Leishmaniasis

message: Written in article: "Neonatal thymectomy  at three days of age in mice results in autoimmunity, suggesting that the thymus has an important role in the generation of Treg cells."
That sentence makes no sense. Of course the thymus plays an important role in the generation of Tregs, like in all T cells. However, in the very first line: Neonatal thymectomy results in autoimmunity due to the lack of negative selection of non-selfreactive T cells. This is not Treg cell specific but T cell specific in general. I would suggest to just leave that sentence out since it does not contribute to the "development" chapter or begin with a sentence like: "All T cells mature in the thymus." No thymus, no T cells.  —Preceding unsigned comment added by 92.76.181.77 (talk) 16:04, 10 June 2010 (UTC)
thread_title:  Development 

message: There are environmental factors involved here too. See Hygiene Hypothesis.
- While Hygiene (capital H) continues to be a favored explanation of the contribution of environment to autoimmunity, this falls outside the scope of this article. The contribution of Tregs to control of autoimmunity need not be in any way exclusive with that of environment factors. Try appending it to Autoimmunity, in the way Allergy invokes it. Jbarin 09:44, 30 April 2007 (UTC)
thread_title:  "The critical role regulatory T cells play within the immune system is evidenced by the severe autoimmune syndrome that results from a genetic deficiency in regulatory T cells." 

message: I just looked at the Molecualr characterization section, so I don't know for others, but this one definately need copy editing. I'm not a native English speaker, but sentences like "Regulatory T cells are also identified by their high levels of CD25 and CD4 expression, while also expressing low levels of CD127", or phrases like "response to a pathogens" don't sound correct to me. And besides, high CD4 and CD25 expression in the cells is described in the first paragraph of this section, so why start the next paragraph with "cells are also identified by their high levels of CD25 and CD4"?
Independovirus (talk) 08:41, 6 May 2009 (UTC)
thread_title:  Molecular characterization 

message: Based on the term's meaning and the fact that this article includes one occurrence of the string "T-reg" and another of the string "Treg," I'm guessing that treg is prounounced in two syllables, kinda like "tea bag," rather than in a single syllable, more like "tread." Am I right? I think the lead ought to specify the proununciation for us unwashed: the few among Wikipedia's readership who aren't immunologists. Even given WP:NOT#DICT, such a scrap of lexical assistance could scarce be considered amiss.—PaulTanenbaum (talk) 20:14, 25 September 2014 (UTC)
thread_title:  Pronunciation? 

message: I would like to see citations for a particular section. 
"Regulatory T cells and disease"
Following;
For example, regulatory T cell activity has been reported to increase in several infectious contexts, such as retroviral infections (the most well-known of which is HIV), mycobacterial infections (like tuberculosis), and various parasitic infections including Leishmania and malaria.[?] Capjo001 (talk) 04:38, 8 February 2015 (UTC)
thread_title:  References  

message: We've got some CD4+, some CD(+) and some CD+. If theres anyone that wants to go through and unify them, that'd be great  -- TobyBrann
== Tregs and Implications for Cancer  ==
I think that this page needs to expand on Tregs and the implications they have for cancers and immunotherapy. I am also planning on editing the wikipedia lead section to include recent research about Tregs and cancer. 
Curiel, Tyler J. "Tregs and rethinking cancer immunotherapy." The Journal of clinical investigation 117.5 (2007): 1167-1174.
Curiel, Tyler J. "Regulatory T cells and treatment of cancer." Current opinion in immunology 20.2 (2008): 241-246.
Li, Hui, et al. "Increased prevalence of regulatory T cells in the lung cancer microenvironment: a role of thymic stromal lymphopoietin." Cancer Immunology, Immunotherapy 60.11 (2011): 1587-1596.
Karanikas, Vaios, et al. "Foxp3 expression in human cancer cells." J Transl Med 6.19 (2008): 1-8.
Lin, Wan-Wan, and Michael Karin. "A cytokine-mediated link between innate immunity, inflammation, and cancer." The Journal of clinical investigation 117.5 (2007): 1175-1183.  — Preceding unsigned comment added by Immacarle14 (talk • contribs) 06:00, 4 February 2016 (UTC)
thread_title:  Consistency 

message: I think that this page needs to expand on Tregs and the implications they have for cancers and immunotherapy. I am also planning on editing the wikipedia lead section to include recent research about Tregs and cancer. 
Curiel, Tyler J. "Tregs and rethinking cancer immunotherapy." The Journal of clinical investigation 117.5 (2007): 1167-1174.
Curiel, Tyler J. "Regulatory T cells and treatment of cancer." Current opinion in immunology 20.2 (2008): 241-246.
Li, Hui, et al. "Increased prevalence of regulatory T cells in the lung cancer microenvironment: a role of thymic stromal lymphopoietin." Cancer Immunology, Immunotherapy 60.11 (2011): 1587-1596.
Karanikas, Vaios, et al. "Foxp3 expression in human cancer cells." J Transl Med 6.19 (2008): 1-8.
Lin, Wan-Wan, and Michael Karin. "A cytokine-mediated link between innate immunity, inflammation, and cancer." The Journal of clinical investigation 117.5 (2007): 1175-1183.  — Preceding unsigned comment added by Immacarle14 (talk • contribs) 06:00, 4 February 2016 (UTC)
thread_title:  Tregs and Implications for Cancer  

message: In 2018  A study from Oxford (McDonald-Hyman) in coordination with a consortium of other academic institutions, proved that the distal pole complex , or DPC, of Tregs is made of vimentin.  Inside Tregs,  the DPC is responsible for their switch from inactive to active, functional states, enabling formation of the immune synapse and Tregs immune dampening function.  The authors proved that vimentin modulation could regulate (control) this switch, and could achieve efficacy endpoints in in vivo models of myasthenia Gravis, an autoimmune disease known to be based on an insufficient Treg response.   From these data, the authors concluded that vimentin regulates the status of Tregs,  and that vimentin "is a translational relevant" target for therapeutic intervention to  activate Tregs to treat conditions of immune imbalance such as autoimmune disease.
This structural biology has been validated in multiple studies, and has been visually demonstrated in a new paper (Li 2021), but remains little recognized relative to its important implications as a novel mechanism  in  Autoimmune disease.  One company, Aluda pharmaceuticals, has demonstrated a vimentin  targeting small molecule can ActivateT regs in this manner and published results in a peer reviewed journal. Dbsbd1260 (talk) 04:12, 1 January 2022 (UTC)
thread_title:  vimentinas the mechanical  regulator of Treg activation