Talk:Cisplatin

message: The previous version contained lots of POV verbage, most of it due to bias or in an attempt to sound like a popular science journalist. Cisplatin "saving lives" is a bit dramatic. JFW | T@lk 15:12, 14 Apr 2005 (UTC)
thread_title:  POV verbiage? 

message: If you click through on this drug, it describes the mechanism of action: disturbance of microtubule dynamics. Suggesting, this latter sentence to be removed removed, which is referenced with article [14]:
"The drug paclitaxel may be useful in the treatment of cisplatin-resistant cancer; the mechanism for this activity is unknown.[14]  — Preceding unsigned comment added by Ansjovis86 (talk • contribs) 14:02, 6 July 2015 (UTC)
thread_title:  Paclitaxel action unknown? 

message: According to this article, Cisplatin causes less resitance among Black women.
http://www.sciam.com/article.cfm?id=cervical-cancer-chemo-eas
A note of caution:
A recent paper on Nature Genetics (Ross et al.2009, Genetic variants in TPMT and COMT are associated with
hearing loss in children receiving cisplatin chemotherapy) shows that there is a race-related difference in the frequency of occurrence of a SNP increasing susceptibility to ototoxicity (and they cite another study regarding nephrotoxicity). Africans seem to be, as a population, more subject to these side effects than Caucasians or Asians.
Perin Paola (talk) 13:06, 24 February 2010 (UTC)
thread_title:  Cervical cancer chemo easier on black women? 

message: says "the c-MYC oncoprotein decreases production of BIN1, a c-MYC inhibitor. BIN1 usually suppresses an enzyme essential for DNA repair. Thus the sensitivity of cancer cells to cisplatin depends upon BIN1 abundance". Rod57 (talk) 15:14, 26 March 2011 (UTC)
thread_title:  BIN1 and c-MYC involved in resistance 

message: I admit that plenty of genuinely reputable sources use the double "M" for the full chemical name.  However, it is unquestionable that "Amine" in any usage, is always used with 1 "m."  perhaps there should be a note about this.  The other names, which are more specific to the use of this chemical as a drug, are not at issue.  The issue is the proper chemical name, which is technically incorrect, though there are journals with it spelled this way.  Any chemist, IUPAC, or other wielder of correct chemical naming conventions will agree 100%.  Doctors (MD) may disagree, but this is SPECIFICALLY a question of the CHEMICAL (as opposed to its "Drug" name) name.  I suggest either a correction or at the very least a note mentioning the discrepancy to alleviate the vast hordes of undergraduates learning about isomerism (this is probably the most widely non-organic pedagogical example of the example of complex isomerism).68.6.76.31 (talk) 06:52, 6 April 2011 (UTC)
replies: text: Well actually, when an amine is a ligand it becomes an ammine; see Ammine complex, and this is the IUPAC recommendation from Nomenclature_of_Inorganic_Chemistry. Just like when water is a ligand it becomes aquo. The names change, although in this case it is slightly confusing because it is so similar to amine. Chris (talk) 10:15, 6 April 2011 (UTC)
thread_title:  Naming 

message: Hello, I have been looking up different references for the side effects. I was wondering how is it possible to get someone to remove the banner regaurding the not cited work under side effects? thank youBeckejac (talk) 17:07, 19 April 2012 (UTC)
thread_title:  Side effect references 

message: My sister is taking Cisplatin right now.  Early on she developed a rather severe problem with something I can only describe as tinitus.  After talking with her doctor she was told that the Cisplatin will cause that in a small percentage of people. highwayman65251 (talk) 16:10, 10 May 2012 (UTC)
thread_title:   Side Effects 

message: The new Platinum-based anticancer drugs from Wikipedia:Wiki Ed/UCLA/Chem 171 Winter 2016 (Winter 2016) should be looked at and if needed merged or ........
--Stone (talk) 20:36, 14 March 2016 (UTC)
thread_title:  Platinum-based anticancer drugs 

message: My name is Florian Schaub at Merck KGaA. My aim is to make some little changes in this article. From our point of view squamous cell carcinoma of the head and neck should be added to the passage "Medical Use". Ormaplatin and Zeniplatin can also be added to "See also". Please let me know if anyone has concerns. 
--Florian Schaub at Merck KGaA (talk) 18:00, 31 May 2016 (UTC)
replies: text: Thanks for the note and the disclosure of your potential COI.  We would only have a Ormaplatin and Zeniplatin under "see also" if we actually had articles to see.  You are welcome to start them if you think that they are notable.  I encourage you to make the changes about the other aspect.  Happy editing.--Smokefoot (talk) 17:34, 31 May 2016 (UTC)
thread_title:   Announce changes 

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thread_title:  External links modified 

message: This is a planar, specifically square-planar molecule, is it not? If it is, why is it shown with (unnecessary) above-plane and below-plane stereochemistry?HowardJWilk (talk) 20:49, 7 May 2017 (UTC)
replies: text: The molecule as a whole is not planar as the hydrogen atoms cannot be arranged symmetrically above and below the plane defined by the chlorine and nitrogen atoms. Petergans (talk) 09:22, 27 February 2018 (UTC)
thread_title:  Structure 

message: The hydrolysis of cis-Pt(NH3)2Cl2) is an equilibrium process, with the following equilibrium constants. Reference  B Kankia,T Funck,L Marky; J.Solution Chem., 28,1249 (1999)
: Pt(NH3)2 Cl2 + H2O</sub>  [Pt(NH3)2(H2O) Cl]++ Cl- ;  logK1=2.60
:[Pt(NH3)2(H2O) Cl]+ + H2O</sub>  [Pt(NH3)2(H2O)2]2+ + Cl- ; logK2=4.52  
Therefore, it is incorrect to say that cis-platin is converted into the di-aqua complex on passing into a cell. What happens is that the uncharged molecule passes through the cell membrane more easily than the charged species. Then, as the chloride concentration is lower inside the cell, the equilibria are shifted to the right, increasing the proportions present of both the mono-aqua complex and di-aqua complex relative to the di-chloro complex, compared to the concentrations present when the platinum complexes are outside the cell. 
In view of the aggressive reactions to my previous edits, I will not make the required changes myself. Petergans (talk) 09:18, 5 March 2018 (UTC)
thread_title:  Equilibrium concentrations 

message: Under Side Effects -> Nephrotoxicity, we have this  sentence: "The dose should be reduced when the person's kidney function."  This is obviously incomplete. Can someone knowledgeable please complete it?  — Preceding unsigned comment added by 58.167.145.28 (talk) 09:07, 8 March 2019 (UTC)
replies: text: Good catch.  Added "impaired" from citation.  Sandcherry (talk) 20:57, 8 March 2019 (UTC)
thread_title:  An obviously unfinished sentence.