Talk:Inflammation

message: I think this section is far too extensive for this article. Other specific, much more classical, examples of inflammation are not discussed here. I think it should be moved to another article, such as Muscle or Exercise. Ehudzel (talk) 15:30, 6 May 2011 (UTC)
thread_title: Exercise and Inflammation

message: This article needs to be reworked in a lot of different ways including conceptually.  The basic problem is that there is no principled distinction between older/classic regional inflammatory concepts ,which this piece presents reasonably well, and newer and equally important concepts about chronic or systemic inflammation, particularly the destructive disinhibition of inflammation in aging (barely mentioned as an afterthought in relationship to diabetes towards the end of the article).  Specifically, one might consult the work of E Sikora, B Aggerwal, S Bengmark, and the classic paper on this by Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.  This work suggests that aging itself may be both a consequence as well as a driver for progressive auto-inflammatory damage.  These concepts have to be seen as having a huge influence on how we understand aging itself and how we might protect ourselves from the accelerated aging associated with the Western lifestyle and diet, which are strongly pro-inflammatory in a number of ways.  It's a shame that despite previous and explicit suggestions about this, the author has chosen to ignore this entire realm of literature completely.  for this reason I am spelling out my differences with this whole approach more explicitly in this extended comment.
First of all, the evidence is now virtually overwhelming that every disease of aging (Alzheimer's disease, cancer, heart disease, diabetes, arthritis, etc. etc.) is associated with long-term damage done by our own immune systems.  For example, there is now solid evidence that the transition from mild cognitive impairment to dementia in patients with Alzheimer's disease is associated with up regulation of various cytokine systems, although it is not so clear what is driving this. There is also enormous evidence that cancer is associated with long-term inflammatory damage to various cell populations, and that upregulation of inflammatory pathways  particularly the transcription factor nuclear factor kappa b, is critical to cancer pathogenesis.  Heart disease is clearly associated with inflammatory processes on the arterial wall (in the context of oxidized lipids) enabling plaque formation.  Diabetes particularly type II diabetes also has a close relationship with this pro-inflammatory transcription factor being upregulated.   
I don't think that any reasonable treatment of inflammation can fail to emphasize all these basic linkages and still claim to be remotely comprehensive.  Additionally, any treatment of the subject would have to at least link to a page on cytokines, which appear to come in both anti-and pro-inflammatory forms. The treatment here also fails to emphasize the relationship between stress and inflammation, between sleep deprivation and inflammation, and between depression and inflammation, as there is increasing evidence that depression is in part mediated by elevated cytokines.   Additionally, treatment fails to mention numerous diseases that may involve dysregulation of inflammatory pathways and cytokines including particularly IBS, fibromyalgia, and chronic fatigue syndrome.  There is also no principled discussion of anti-inflammatory drugs or anti-inflammatory foods, and there is more and more evidence that omega-3 supplementation is valuable because it reduces systemic inflammation (the omega-3 pathway competes with the omega six pathway for the same enzymes, and the omega six pathway promotes prostaglandins and other pro-inflammatory molecules.)  Clearly there are a lot of things that could be improved here, but I would start with an emphasis on how the immune system cuts both ways, it clearly is essential for our survival, but its chronic overactivity may contribute hugely to diseases of aging and even to aging itself.  This potentially makes the topic a lot richer and a lot more interesting.  
Indeed it looks like one of the critical ways to prevent many of the diseases of aging is to keep the innate immune system under control by ensuring a good nights sleep, regular exercise, and an anti-inflammatory diet (decent amounts of fruits and vegetables and a good amount of omega-3, with not too much omega 6, or processed carbohydrates).  DFWatt Harvard Medical School.  —Preceding unsigned comment added by 67.110.143.19 (talk) 18:41, 24 April 2008 (UTC)
thread_title: General Concerns and Suggestions

message: In the textbook Pathophysiology: Concepts of altered health states (7th edition) by Porth it says that the 5th cardinal sign "loss of function" was added by Galen in the 2nd century AD, not in the 19th century by Ahmed Abou Samra. Google searches containing one name and the term "loss of function" or the latin "functio laesa" seem to indicate that porth was correct. It also says that Celsus termed the first four signs in the 1st century AD if that helps anyone at all.58.170.163.218 (talk) 12:21, 9 April 2008 (UTC)
thread_title: Fifth cardinal sign

message: The bit about systemic inflammation is intrigueing, twood be nice to have a page on it! Wblakesx 19:11, 18 March 2007 (UTC)
thread_title: Systemic inflammation 

message: I removed a bit of advertising text that seems to have been maliciously inserted.  The text was "See www.softecare.com for information on anti-inflammation Soft-E-Lotion" Jwinget 18:37, 5 September 2006 (UTC)
thread_title: Advertisment

message: I would keep acute and chronic together, with specifics on chronic inflammatory disease issues in the relevent articles, give a chance for contrasting acute and Chronic in the same article.  Steve Kd4ttc 14:46, 6 Jun 2004 (UTC)
thread_title: Chronic inflammation merge

message: WHICH CHEMICAL CAUSE INFLAMMATION?
Hope this will answer your question:
NSAIDs are COX inhibitors that inhibit the enzyme cyclooxygenase from transforming arachidonic acid (a derivative of cell membrane phospholipids) to prostaglandins. The prostaglandin family contributes to an inflammatory response mainly by increasing vasodilatation and vascular permeability. If the formation of the different arachidonic acid metabolites in the prostaglandin family is inhibited, some of the cardinal signs of inflammation might be decreased. Use of COX inhibitors, such as aspirin, will also decrease the ability of platelets to adhese and form a primary clot (see hemostasis and coagulation for more info on the formation of a blood clot) This is because COX inhibitors inhibit the formation of thromboxane (TXA2) in platelets. When used excessively, most NSAIDs might predispose to gastric ulceration by inhibiting COX-1. Some of the prostaglandins produced in the cyclooxygenase pathway are essencial for the protection against acid induced damage of the gastric mucosa and by inhibiting COX-1, the production of these metabolites is decreased. Recently, selective COX-2 inhibitors have been developped, obliterating the harmful effects of the COX-1 inhibitors on the gastric mucosa. However recent studies have shown that these drugs might lead to acute coronary artery disease.
Yours Sincerely
Helge-André Flakk 
Norwegian Dentist
  —Preceding unsigned comment added by 194.54.110.98 (talk) 21:47, 24 April 2008 (UTC)
thread_title: question

message: So, here is the real issue: a lay reader is not going to be expecting this page to include depictions of the pathology anywhere near that graphic. I'm not sure why wikipedia doesn't have a standardized graphic-images warning, because this seems to be a textbook case where one would be important - at least for managing expectations and preparing oneself. Most viewers of this page will NOT be specialists. Many will be newly diagnosed with an inflammatory condition and looking for help. Clearly the images are important and should remain, but I found the images traumatic to view and would have been prepared for them with a simple warning.
it is very hard to watch them.. do something... GOER 11:52, 21 July 2007 (UTC)
thread_title:  extremely graphic images 

message: I have started a new page called inflammatory diseases of unknown etiology and would like some help  answering these questions: What are the inflammatory diseases of unknown etiology? How many of them are there? What are the most common inflammatory diseases of unknown etiology? What kind of inflammation is associated with inflammatory diseases of unknown etiology? And how many kinds of inflammation patterns are there in inflammatory diseases of unknown etiology? If anyone has the time to contribute it would be appreciated. ReasonableLogicalMan(Talk 20:32, 18 November 2007 (UTC)
thread_title: Need Help

message: Shouldn't this page include a section on treatment options to be of service to those who suffer from chronic inflammatory conditions? FQ1513 (talk) 23:25, 22 December 2007 (UTC)
replies: text: Not necessarily.  Inflammation is a perfectly normal process.  It doesn't necessarily need to be treated at all, and even when it does, the best treatment depends on the actual cause.  A treatment section would basically boil down to "Inflammation normally goes away by itself, and when it doesn't, then you need to figure out the cause and treat the cause."  A list of all possible treatments for all kinds of inflammation would be a mile long and basically useless.  WhatamIdoing (talk) 19:45, 23 January 2008 (UTC)
thread_title:  treatment options? 

message: pictures may detract from readability for some readers. --Emesee (talk) 16:08, 25 January 2008 (UTC)
thread_title:  pictures may detract from readability for some readers. 

message: I don't believe the term "polymorphonuclear leukocytes" is used anywhere on the page as it is now. It might add to the page if the term was mentioned where appropriate. ReasonableLogicalMan(Talk 02:44, 26 February 2008 (UTC)
thread_title: polymorphonuclear leukocytes

message: I was given COX-2 inhibitors to get rid of a painful inflammation in my hand that persist for several weeks (I lift weights, was on a month off, pulled a muscle when I came back).
I was surprised to find that muscle strain is not listed as causing inflammation. Indeed, the article implies such inflammation is either an external entity (virus) or autoimmune problem. From other inet sources I've learned that pulled muscles have broken fiber, leading to inflammation which is mostly self-sustained (in a way, an autoimmune problem) hence COX-2 inhibitors treatment resolve the issue. I'd like to see details added here by a professional.  —Preceding unsigned comment added by 79.176.101.39 (talk) 17:25, 6 February 2009 (UTC)
thread_title:  muscle strain inflammation 

message: "Inflammation is the complex biological response of vascular tissues..." Vascular tissue seems to be a term from plant biology. Does this intro' sentence mean "blood vessels" or "tissue infused with blood vessels"? If you know, please clarify. Anthony (talk) 14:35, 7 October 2009 (UTC)
thread_title:  The first sentence

message: Some of the previous posters are correct. Particularly, the first picture detracts from the readability/digestibility of the article. If you (the reader) are in favor of this picture, please try not to take offense at the following remarks, but please try to look at the criticism objectively. The picture needs to be more "diplomatic", and not offensive to 30 to 50 to who-knows-what percentage of the readers. Just because the picture-insert-er and this article's favorite moderators have developed a stomach for such a picture (with extra-articular information such as necrotic tissue and puss in the middle) does not mean that they should show their stamina off to the rest of the population. Again, if you (the reader) are one such as this, please, try not to take offense at the anti-current-picture camp's remarks, but objectively look at the picture, the article's title, and what others have said before me.
This site is not intended to be a comprehensive, professional, medical resource per se, but is a reference for the general population of the world. It should not be forcing it's subscribers to high-tolerance-necessary, professional, overkill photos, just because someone found or created what was to them "the perfect photo" for what belongs to a more specialized topic than "Inflammation", or to a professional medical reference where the subscribers are expected -- by the nature of their career -- to have developed the tolerance/stomach for such images.
In summary, the previous objectors have a point, and it ought not be ignored only because of their potential lack of credentials. At least, the more offensive pictures should be found at the bottom of the article, if not instead as part of a more acute or specialized article on the subject to which "black rings of necrotic tissue surrounding pus" might more readily pertain, particularly as a greeting photo. It can be assumed that when the general population of the world goes looking for an article on "inflammation", they are likely not thinking of "black rings of necrotic tissue, surrounding central areas of pus", both of which are not even a component of "Inflammation". The picture that should be used as the greeting picture, should be one that has as it's prominent feature, the five "cardinal signs" of inflammation (necrotic tissue and pus "not" being members of this list). The current greeting picture clearly should be changed or removed.
Hypocritus (talk) 16:20, 16 June 2010 (UTC)
replies: text: Would  be better? Anthony (talk) 09:40, 20 September 2010 (UTC)
replies: text: . Anthony (talk) 04:30, 27 September 2010 (UTC)
thread_title:  Pictures, Particularly the Greeting Photo 

message: Trying to stick fibrosclerosis into some category, I noticed that eg sarcoidosis does not have the inflammation category either. How to add them into some template/category? Richiez (talk) 08:13, 20 September 2010 (UTC)
thread_title:  New category/template for diseases with significant inflammatory  factor but unknown/diverse etiology? 

message: Any reason that 'Interstitial Cystitis' in the list of inflammatory disorders is not linked to the page with that title? Seems like a no-brainer, to a layman anyway ...  —Preceding unsigned comment added by Foolishearthling (talk • contribs) 15:16, 30 April 2011 (UTC)
thread_title:  Question 

message: * Bronchial asthma and other neurogenic diseases: migraine, trigeminal neuralgia and epilepsy
* Schön and Boehncke, Psoriasis: Neurogenic inflammation and other mechanisms NEJM 352:1899-1912, Number 18, 2005
There may be helpful research for expanding this article in the discussion section, http://en.wikipedia.org/wiki/Talk:Neurogenic_inflammation.
Ocdnctx (talk) 13:03, 1 May 2011 (UTC)
thread_title: External links

message: The study of inflammation is exploding.  
Perhaps sections are needed on role of inflammation in promoting 
Diabetes?  
Inflammation and cancer?  
Inflammation and circulatory/cardiac disease (fairly recent recognution of the role of  "unstable plaques").  
Ocdnctx (talk) 20:05, 1 May 2011 (UTC)
thread_title:  Perhaps a section is needed on role of inflammation in promoting diabetes?  Inflammation and cancer?   

message: The complete section to atherosclerosis is barely a copy of the abstract of the paper by Libby, Ridker and Maseri, "Inflammation and atherosclerosis." published in circulation in 2002.  — Preceding unsigned comment added by 145.100.194.53 (talk) 21:32, 7 November 2011 (UTC)
thread_title:  section atherosclerosis 

message: Can somebody please add the benefit of sufficient and regular sleep for inflammation to this article - it is VERY surprising that, at time of writing, the word "sleep" doesn't even appear in it. --New Thought (talk) 20:00, 5 August 2012 (UTC)
thread_title:  Sleep 

message: Two claims are made: (1) that "negative cognition" causes inflammation and (2) that inflammation causes depression. While the latter is plausible (if not particularly interesting), the former is surprising and calls out for strong evidence. The citation given is a psychology paper about social prejudice and depression, and inflammation is not mentioned in the abstract. Even if the paper does claim thoughts cause inflammation, establishing this seems well beyond its scope. 216.239.45.130 (talk) 00:14, 9 July 2013 (UTC)
thread_title:  Depression 

message: New user here, but anyway: Signal-to-noise section was added by only one user and has a video as source? Although the idea makes sense to me, can this section be considered a "real" information?  — Preceding unsigned comment added by 130.234.128.196 (talk) 21:53, 25 November 2013 (UTC)
thread_title:  Signal-to-noise theory 

message: Substituted at 18:55, 29 April 2016 (UTC)
thread_title: Assessment comment

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thread_title:  External links modified 

message: The following Wikimedia Commons file used on this page has been nominated for deletion:
* Allergy to Antibiotic Cefaclor.JPG
Participate in the deletion discussion at the nomination page. —Community Tech bot (talk) 02:01, 3 November 2018 (UTC)
thread_title:  A Commons file used on this page has been nominated for deletion 

message: In the Leukocyte extravasation section there is an image caption ("Inflammation is a process...") that is garbled in at least two places: "The (phagocytes)White blood cells" and "the body's defense system the immune system triggers". Also, the relevance of the caption to the image (and vice versa) is not obvious, and the content of the caption might be better placed in the body text (if not already covered). Could someone competent please have a butcher's and make any appropriate changes? Thanks. - --Frans Fowler (talk) 07:47, 29 September 2021 (UTC)
thread_title:  Garbled caption