Talk:Homocysteine

message: It's more precisely descriptive to use scientific language when discussing chemical structure and actions.Lynxx2 (talk) 15:44, 4 June 2016 (UTC)
thread_title:  This page is indeciferable. Please add some plain english. 

message: The page Hyperhomocysteinemia already exists and has some overlapping information with this page.
It may be more appropriate to move anything related to elevated homocysteine to the Hyperhomocysteinemia page. Manfred Bartz (talk) 12:19, 9 January 2013 (UTC)
thread_title:  Proposal to move disease related info to Hyperhomocysteinemia 

message: Could be most cases are sub-clinical Hypothyroidism?   —Preceding unsigned comment added by 63.245.153.165 (talk) 03:19, 29 November 2009 (UTC)
thread_title:  Hypothyroid causes high homocysteine levels 

message: ===not helpful===
 inserted the news item that taking B vitamins was not helpful. This has not been published yet - it was an abstract at the European Society of Cardiology, presented on 5/9/2005 by Bonaa KH et al  . I think we should scan the literature in a few months to see which large journal will be publishing this finding. JFW | T@lk 16:58, 6 September 2005 (UTC)
thread_title: Vitamin B

message: inserted the news item that taking B vitamins was not helpful. This has not been published yet - it was an abstract at the European Society of Cardiology, presented on 5/9/2005 by Bonaa KH et al  . I think we should scan the literature in a few months to see which large journal will be publishing this finding. JFW | T@lk 16:58, 6 September 2005 (UTC)
thread_title: not helpful

message: This is incomprehensible:
As B12 is inefficiently absorbed from food by elderly persons they could gain a greater benefit from taking vitamin supplements. 
Greater than from what? Which of the mentioned vitamins? --Espoo 20:11, 20 June 2006 (UTC)
thread_title: absorption and supplementation

message: "Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics." by Saibeni S, Lecchi A, Meucci G, Cattaneo M, Tagliabue L, Rondonotti E, Formenti S, De Franchis R, Vecchi M.; Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Maggiore Hospital and University of Milan, Milan, Italy.
* BACKGROUND & AIMS: Hyperhomocysteinemia, a risk factor for thrombosis, recurrent miscarriages, and osteoporosis, might derive from acquired folate and vitamin B 12 deficiencies and from a C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) gene. Undiagnosed gluten-sensitive enteropathy (GSE) is associated with vitamin deficiencies, osteoporosis, and recurrent miscarriages. We evaluated the prevalence and the risk factors for hyperhomocysteinemia in patients with newly diagnosed GSE. 
* METHODS: In this prospective study performed in a tertiary care setting, 40 consecutive subjects with newly diagnosed GSE were evaluated for homocysteine, folate, and vitamin B 12 levels and for C677T polymorphism. One hundred twenty sex- and age-matched healthy control subjects were studied. Nonparametric tests and multiple regression analysis were used to evaluate the risk factors in inducing hyperhomocysteinemia in the GSE population. 
* RESULTS: Hyperhomocysteinemia was more frequent in GSE patients than in control subjects (8/40, 20.0% vs 7/120, 5.8%) (relative risk, 3.4; 95% confidence interval, 1.3-8.9), as well as folate deficiency (17/40, 42.5% vs 10/120, 8.3%) (relative risk, 5.1; 95% confidence interval, 2.5-10.2). Multiple regression analysis showed that folate and B 12 levels were independently and inversely associated with homocysteine levels, whereas homozygosity for the MTHFR thermolabile variant was not. The prevalence of MTHFR variant in GSE population was not different from that reported in racially comparable control groups. Gluten-free diet was able to normalize folate, vitamin B 12 , and homocysteine levels. 
* CONCLUSIONS: Hyperhomocysteinemia is frequent in newly diagnosed GSE. Vitamin deficiencies caused by malabsorption are the most important determinants of this condition. Hyperhomocysteinemia might contribute to the occurrence of common complications of undiagnosed GSE.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15952099&dopt=Abstract
PMID: 15952099 [PubMed - indexed for MEDLINE]
--Renice 05:11, 24 March 2007 (UTC)
thread_title: gluten sensitivity complications

message: Connection with dementia and other neurodegenerative diseases?
 "Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency" by Jonathan D Picker, MBChB, PhD; Harvey L Levy, MD 
*Characteristics:
**developmental delay/mental retardation
**ectopia lentis and/or severe myopia by age 8
**skeletal abnormalities (excessive height and length of the limbs) [i.e., may look like Marfan's syndrome], prone to osteoporosis
**thromboembolism (major cause of early death and morbidity)
*Other features that may occur:
**seizures
**psychiatric problems
**extrapyramidal signs such as dystonia
**hypopigmentation
**pancreatitis
**malar flush
**livedo reticularis
*Two phenotypic variants recognized:
#B6-non-responsive homocystinuria
#B6-responsive homocystinuria (typically milder expression)
[just holding this here until someone can incorporate relevant bits]
--Renice 05:58, 24 March 2007 (UTC)
thread_title: Cystathionine Beta-Synthase Deficiency

message: if homocysteine is not obtained from diet as the article claims and homocysteine forms methionine, how can methionine be an essential amino acid? -- Bubbachuck (talk) 09:14, 13 January 2008 (UTC)
replies: text: homocysteine forms cysteine, not methionine. methionine is what it's formed from.  —Preceding unsigned comment added by 79.71.77.24 (talk) 10:27, 23 July 2008 (UTC)
thread_title:  not obtained from diet? 

message: I am a 40 year male (Indian - Punjab) and last week experienced a stroke. I felt serious numbness in my right limbs and lost control of the right side of my mouth. I could not talk properly and rushed immediately to the hospital. I was lucky and recovered.
The Docs say there was a very small clot in the brain (the report says - MRI done showed, old infract in the left cerebellar hemisphere with subtle hyper intensity seen inthe left frontal region...).
On testing found everything within limits except for HOmocysteine - which recorder at 74.15 umol / L.
Could this be the reason for the clot in my head?
I work out at the gym 2 hours daily, could heavy exercise give rise to higher levels of homocysteine? I dont want to leave going to the gym.
I would appreciate all who can advice me on further course of action.
Thank you
Parminder.B.Singh
parminderbsingh@yahoo.co.in  —Preceding unsigned comment added by 121.245.79.251 (talk) 16:55, 9 July 2009 (UTC)
thread_title:  Effect of Homocysteine regarding strokes 

message: Try to lower HCy, get cancer risk increase instead http://jama.ama-assn.org/cgi/content/abstract/302/19/2111 JFW | T@lk 22:59, 17 November 2009 (UTC)
thread_title:  Cancer 

message: The list of references needs a good copy-edit. Some refs have inadequate information as well as inconsistent formatting. And the rest of the article could do with updating. Tony (talk) 12:45, 28 May 2010 (UTC)
thread_title:  Clean up 

message: The opening sentence declares that homocysteine is a non-protein amino acid. Reading this I'm not sure what it means. Is it that this amino acid (one of "the building blocks of protein") doesn't occur in proteins, doesn't occur in the usual proteins (whatever that set may be) or cannot occur in proteins? Does it mean something else, perhaps that homocysteine has a "non-protein role" in the body? Could someone who knows expand the shorthand "non-protein" to say exactly what is meant? 78.144.77.146 (talk) 11:23, 31 July 2013 (UTC)
replies: text: Proteins are chains of amino acids. Some AAs are made in the body. Some are not, and must be obtained from food. In addition, there are amino acids that are not incorporated into proteins. See the Wikipedia entry on non-proteinogenic amino acids.David notMD (talk) 11:44, 26 February 2017 (UTC)
thread_title:  Non-protein amino acid 

message: "A high level of homocysteine makes a person more prone to endothelial injury, which leads to vascular inflammation, which in turn may lead to atherogenesis... "
should that really say atherogenesis, or are we referring to atherosclerosis?24.21.86.182 (talk) 18:44, 1 September 2013 (UTC)
thread_title:  intro 

message: Section added since Homocystine redirects here and is not in fact the same chemical.  This is s 'stop gap' to avoid misinformation.  A better reference is needed as is mention of homocystinuria.  Homocystine probably is not important enough to warrant it's own page.  Leopardtail (talk) 18:35, 27 May 2014 (UTC)
thread_title:  Homocystine 

message: I noticed there was a request for documentation or citation on normal homocystine levels.
I couldn't find anything from the Framingham study that discussed this straight out, despite being implied.
But the numbers seem correct.
I think this might be a valuable link
http://www.emedicinehealth.com/homocysteine/page4_em.htm
If so you can add the citation and adjust the test.
Hope this helps  — Preceding unsigned comment added by Cdmphy (talk • contribs) 22:46, 7 April 2016 (UTC)
thread_title:  Normal Levels 

message: Substituted at 18:12, 29 April 2016 (UTC)
thread_title: Assessment comment

message: HomocystIne redicts to this page, and one part refers to HomocystIne as if it were an alternative spelling.
HomocystIne is however a compound formed of two HomocystEIne molecules with a disuplhide bond.  This page either needs  section covering Homocystine (not ideal) or the page for that molecule needs to be restored.
--Leopardtail (talk) 13:48, 21 May 2017 (UTC)
thread_title:  Confusion of Amino Acids 

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