Talk:Cytochrome P450

message: Although I have no text books available to confirm this, my lecturer (and my lecture notes) seem to suggest there are in fact 21 families?
There are a great many more than 21 CYP families. At last count (Oct 2006) there were 6422 known sequences in 708 families (99 in animals). Jed 21:43, 14 November 2006 (UTC)
thread_title:  Only 18 families? 

message: This page needs serious work in order to remove some plain falsities and add valuable information that is now known about the enzyme family.  I'll work on this article after I finish my thesis...on computational study of P450s.  ju66l3r 20:00, 9 November 2006 (UTC)
replies: text: Agreed.  I removed some of the blatantly weird additions (like BM3 under human p450s?) at the time.  I figured if something that wrong was in there, then it's quite possible I missed even more in my haste.  There are quite a few things this article could use, including comments on some of the latest research as well.  ju66l3r 06:15, 15 November 2006 (UTC)
thread_title:  Serious work needed 

message: I'm trying to keep the nomenclature consitent, with the official name (CYP#letter#) first and the common name following in parentheses. As the sequences proliferate it becomes useful to try to keep the nomenclature consistent. Contact David Nelson, the P450 nomenclature guy, if you have comments on the specifics of the nomenclature. Jed 21:53, 14 November 2006 (UTC)
thread_title:  Nomenclature 

message: Colleagues, does anybody know why on earth this article is titled "Cytochrome P450 oxidase"? The widely accepted, if not quite correct, name of this superfamily is "cytochrome P450" (CYP for short); many people nowadays prefer to call it simply "P450" (in contrast to cytochromes, which are purely electron-transfer proteins, P450s are enzymes). It seems that this article started as "P450", then was renamed "Cytochrome P450 oxidase". It is unfortunate name, since (by analogy with cytochrome c oxidase) one can think this is the enzyme that... oxidizes cytochrome P450! Moreover, "oxidase" cannot be applied to all P450s since some of them are not classified as oxidoreductases at all. (See P450-containing systems). I suggest renaming this article back to "P450". Metalloid 01:10, 9 February 2007 (UTC)
replies: text: I believe P450 may be too short of a title, but I do agree that oxidase is not reasonable because not all P450s are oxidases and more importantly the article is not about oxidases of cytochrome P450s as correctly pointed out.  I would suggest Cytochrome P450 as a better title than just P450 or the current title.  ju66l3r 18:49, 9 February 2007 (UTC)

text: I've moved the article as requested.  I actually merged the histories of the article and the redirect that was previously at Cytochrome P450 - the first three edits in the history contain content that was merged to the article Cytochrome P450 oxidase in the fifth edit. -GTBacchus(talk) 02:32, 15 February 2007 (UTC)
replies: text: Thanks, GTBacchus.  ju66l3r 07:42, 15 February 2007 (UTC)
thread_title:  Title 450 

message: I don't think that the "main" reaction carried out by P450's should be listed in the introductory paragraph. Many important reactions carried out do not have that stoichiometry, and while it's perhaps useful to have it listed, I feel that it should be further down the page. I'm commenting here rather than making the edits to gather opinions. Jed 15:05, 26 February 2007 (UTC)
replies: text: The formula itself might be better placed in the article body and not the WP:LEAD but can you suggest alternative text that would summarize the fact that this enzyme is very notable because of the interesting chemistry performed by most of the members of the family?  I wouldn't remove it without something to replace it that would still explain the highly interesting biochemistry for which P450s are known.  ju66l3r 19:17, 26 February 2007 (UTC)
thread_title:  Introduction needs work 

message: There are quite a number of human P450 families listed here that aren't mentioned by the Human Cytochrome P450 (CYP) Allele Nomenclature Committee.  Are they just listing the ones with known polymorphisms?
This is even more confusing in the light of Dr Nelson's count, which differs from both ours and the Committee's (for example, we don't list 2B7 as a pseudogene, and in fact seem to be pretty spotty in our coverage of pseudogenes, and Dr. Nelson doesn't list 2C11, 2U or 2W at all, among others.).
Of course, Dr. Nelson's page seems to be about 7 years old, so that could account for some of the discrepancies.--Slashme 21:23, 4 March 2007 (UTC)
replies: text: It appears that the Human Cytochrome P450 (CYP) Allele Nomenclature Committee is indeed listing ones with known polymorphisms. For example, they're missing CYP51, probably the most ancient of CYPs, which is essential to the synthesis of cholesterol. I don't believe that there are polymorphisms in CYP51. David has recently updated his human CYP list to include lots of pseudogenes, so I'll link to there. We're not exhaustive - that's his job (well, he doesn't have grants to do it, but he does get paid to be a professor). Jed 22:14, 9 March 2007 (UTC)
thread_title:  How many families, how many genes? 

message: The intro says "found in bacteria, archaea and eukaryotes".  That is all three domains of life (excluding viruses).  This says that CYPs are found generally in all forms of life; are they found specifically in all known species?  That would allow the introduction 71.41.210.146 18:37, 23 June 2007 (UTC)
replies: text: Well, I'm not quite sure.  They have been found in a huge number eukaryotes, some archaea, and most bacteria.  I'm not sure whether all archaea and all bacteria have CYPs, though.  I'd actually be quite surprised.  And even if that were true, by saying it that way you neatly dodge the question of what you call "life", and you also avoid such picky description as "cellular life" or "membrane-bound organisms" or what not. --Slashme 08:13, 25 June 2007 (UTC)
replies: text: Not all organisms have CYPs. This is particularly evident in bacteria and archaea, but there are also eukaryotes that do not have any CYPs (ie Giardia, although that's a case of a parasite presumably discarding unneeded genes). Jed 21:17, 9 July 2007 (UTC)
thread_title:  Are CYPs found in all life? 

message: Placing this here just in case that something is missing in the article.
CYP11A1;   CYP11B1;   CYP11B2;   CYP17A1;   CYP19A1;   CYP1A1;    CYP1A2;    CYP1B1;
CYP20A1;   CYP21;     CYP21A2;   CYP24;     CYP24A1;   CYP26A1;   CYP26B1;   CYP26C1;
CYP27A1;   CYP27B1;   CYP27C1;   CYP2A13;   CYP2A6;    CYP2A6V2;  CYP2A7;    CYP2B;
CYP2B6;    CYP2C18;   CYP2C19;   CYP2C8;    CYP2C9;    CYP2D6;    CYP2D7P1;  CYP2E1;
CYP2F1;    CYP2J2;    CYP2R1;    CYP2S1;    CYP2U1;    CYP2W1;    CYP39A1;   CYP3A3;
CYP3A4;    CYP3A43;   CYP3A5;    CYP3A7;    CYP46A1;   CYP4A11;   CYP4A22;   CYP4B1;
CYP4F11;   CYP4F12;   CYP4F2;    CYP4F22;   CYP4F3;    CYP4F8;    CYP4V2;    CYP4X1;
CYP4Z1;    CYP4Z2P;   CYP51A1;   CYP7A1;    CYP7B1;    CYP8B1;    PTGIS;     TBXAS1;
Biophys (talk) 03:02, 11 December 2007 (UTC)
thread_title: Human P450s

message: With due respect to Biophys, I reverted the 11 December edits, for the following reasons:
while many eukaryotic CYPs are membrane bound, a very significant and important fraction is not, and the roles and functions of eukaryotic P450s are far far more than hydrocarbon oxidation. Jed (talk) 17:41, 8 January 2008 (UTC)
replies: text: I agree and to only comment on hydrocarbon oxidation is a bit too overgeneralized.  ju66l3r (talk) 17:27, 9 January 2008 (UTC)
thread_title: Eukaryotic P450's

message: Is anyone familiar with Protein Box Bot? If so, would they be able to insert this in place of the Template:pfam? Jed (talk) 19:36, 18 March 2008 (UTC)
thread_title: Protein Box Bot

message: Hi,
I have put in a diagram that I drew for my thesis (now already published: Not a commercial work, and author's permission granted ;-) and the accompanying description and references.  I think this could do with a once-over from the P450 experts here. --Slashme (talk) 11:17, 5 July 2008 (UTC)
thread_title:  Catalytic cycle 

message: I have converted the steroidogenic pathway diagram to SVG.  Now it needs proofreading.  Note that for simplicity, I have only shown the stereochemistry of each functional group the first time that it appears in the diagram. --Slashme (talk) 16:28, 3 August 2008 (UTC)
thread_title:  New diagram 

message: You have a list of stuff that inhibits p450 but what enhances or turns it on? Thanks.Interestedperson (talk) 00:47, 3 February 2009 (UTC)
replies: text: As I have time I will work on a CYP induction section. It's very complicated, as there are 59 distinct isoforms, each with its own role and therefor each with its own set of inducers. I can cover the basics, but it might end up being a distinct page. Jed (talk) 17:46, 9 February 2009 (UTC)

text: Because the IUBMB is not the P450 nomenclature committee. Jed (talk) 19:15, 4 May 2010 (UTC)
thread_title: P450 enhancement

message: In the mechanism section it's said that the "peroxide shunt" is from the ferrous iron form to the Fe(v) form "compund 1" (the route titled "S" in the picture). But when I got it right from the literature (e.g. in the cited book [8] on page 183) the Fe(v)-form is formed from the ferric iron form through the peroxide shunt mechanism. Does anybody know it excactly and may change this...  —Preceding unsigned comment added by 82.82.72.130 (talk) 15:56, 21 February 2010 (UTC)
thread_title:  Peroxide shunt 

message: Among a few minor grammatical 'enhancements', I changed the statement under Drug metabolism, that read - All drugs are detoxified... to Most drugs undergo biotransformation..., since All is a word you don't want to use in the biological sciences as well as None, Never, Always etc; plus it's just not true: some drugs are excreted unchanged i.e. eliminated.
The statement under Drug interaction, that inhibition of the CYP causes accumulation of the drug to toxic levels possibly causing an overdose is inaccurate even from the definition in the overdose article itself.  —Preceding unsigned comment added by Edu32 (talk • contribs) 19:11, 14 April 2010 (UTC)
thread_title:  Minor changes 

message: Why is there no information about CYP119?  —Preceding unsigned comment added by 173.180.36.54 (talk) 05:55, 22 March 2011 (UTC)
replies: text: Because no-one had gotten to it. Added now. Jed (talk) 16:09, 9 May 2011 (UTC)
thread_title:  CYP119 

message: Other publications refer to DAF-9 as a cytochrome P450 (found in Caenorhabditis elegans). Should it be mentioned here ? - Rod57 (talk) 02:21, 22 February 2012 (UTC)
replies: text: Yes. Jed (talk) 15:13, 7 May 2012 (UTC)
thread_title:  DAF-9 

message: Have any studies been done on P450 disorders?  — Preceding unsigned comment added by 99.190.133.143 (talk) 18:00, 9 April 2012 (UTC)
replies: text: Here's one reference: . I'm not certain such disorders are directly relevant to the article, but would make an interesting stand-alone article. Cheers, JoeSperrazza (talk) 20:30, 9 April 2012 (UTC)
replies: text:  Yes, disorders in a number of different P450s lead to various diseases, often due to defects in steroid or lipid metabolism. Such include cerebrotendinous xanthomatosis, glaucoma, congenital adrenal hyperplasia, Antley-Bixler Syndrome, and many others. One of these days I'll get to it.... 15:13, 7 May 2012 (UTC)
replies: text: On that subject It could be interesting to check if any studies have been done on the effect of specific anti-P450 used in association with pesticide, and in particular piperonyl butoxide. it seems human share the same process with insects when it comes to Cytochrome. F  — Preceding unsigned comment added by 188.4.116.58 (talk) 15:30, 27 April 2013 (UTC)
thread_title:  What about P450 disorders? 

message: I just arrived here from the article Unspecific monooxygenase. Unfortunately, that article was difficult for me to understand, but it seems that it may be appropriate to merge it into this article. I hope someone with more expertise than me can attend to this issue. If it is decided not to merge it into this article, it would be great if Unspecific monooxygenase could at least be made slightly more understandable to a non-enzymologist.Onefireuser (talk) 17:30, 21 May 2013 (UTC)
thread_title:  Merger proposal 

message: a lot of bodybuilders take liver tablets.  they claim it helps endurance due to the p450, and they cite this study by ershoff:
Proc Soc Exp Biol Med. 1951 Jul;77(3):488-91
'Dr. B. H. Ershoff took three groups of rats and fed them controlled diets for a twelve week period. Group one ate a basic diet fortified with vitamins and minerals. Group two ate as much as they wanted of the same diet plus B vitamins and brewer's yeast. Group three ate the basic diet but had 10% desiccated liver added to their rations.
Then the doctor placed the rats one by one into a drum of water, out of which they could not climb, it was either swim or drown. The group one rats swam an average of 13.2 minutes. Group two, an average of 13.4 minutes. Group three, however, were still swimming at the end of two hours.'  — Preceding unsigned comment added by 108.184.252.247 (talk) 06:36, 25 May 2013 (UTC)
thread_title:  rat swimming endurance study, using liver in diet 

message: "Hydroxylate estrogen" is not a subfamily.
The text is badly garbled.
69.72.92.100 (talk) 23:21, 21 December 2015 (UTC)
replies: text: Agreed, it looks like the paragraph under the list was accidentally damaged by a cut / copy / paste blunder, but unfortunately, I don't understand enough biochem to correct it, however the change log may provide enough context to correct the damage. I will take a look. < time passes > ...I checked into it ( also tried to learn how to use WikiBlame to search within sections, but I am too stupid to figure it out right now ). I eventually discovered that the garbled text was inserted in a single operation ( see https://en.wikipedia.org/w/index.php?title=Cytochrome_P450&type=revision&diff=588826965&oldid=579961603 ) so there's not enough context for me to fix it. :-( 173.238.112.194 (talk) 01:59, 25 December 2015 (UTC)
thread_title:  InterPro subfamilies 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: P450 has many important functions, it has many different genes and it's quite difficult to get a grasp of it at first. 
I was very confused about the nomenclature, I had to look further to understand it better. 
The InterPro has a good basic explanation.
But what can probably most help is the first article about the evolution of this gene and how they named it:
* Evolution of the cytochrome P450 genes. Xenobiotica 19: 1149-1160
Some other related articles:
* Evolution of cytochrome p450 genes from the viewpoint of genome informatics.  
* The evolutionary history of Cytochrome P450 genes in four filamentous Ascomycetes 
* The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s
I'm will leave this here so it may be useful for someone. I also may use it later as a reference in the article.
–Arthurfragoso (talk) 07:07, 26 May 2019 (UTC)
replies: text: Thanks for the refs.  I agree that the lead was not as clear as it could have been.  I have edited and hopefully it is now clearer. Please don't hesitate to jump in and make further edits.  Boghog (talk) 10:26, 26 May 2019 (UTC)
thread_title:  Nomenclature and the evolution of the P450 gene 

message: "Too many to list" is found in some table cells when it is blatantly not the case due to things like formatting that could be used. This should be replaced with a list of pseudogenes, which could be collapsed by default if necessary. Anditres (talk) 23:22, 8 May 2022 (UTC)
thread_title:  CYP families in humans: "too many to list" 

message: The redirect CYP81A has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  Mdewman6 (talk) 22:42, 26 July 2023 (UTC)
thread_title:  "[[:CYP81A]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] 

message: — Assignment last updated by KemiahOwoh (talk) 19:12, 13 February 2024 (UTC)
thread_title: Wiki Education assignment: BMSC 4309 Nutritional Biochemistry and Metabolism

message: This article would benefit from splitting because the topic is massive.  There are many hundreds or thousands of P450s.  The present article is a magnet for citing comments on each of these specialized derivatives.  One idea is to have:
*master article on Cytochrome P450 that describes the enzyme architecture and machinery and mechanism.  
*everything else, lists of individual P450's, occurrence in various species
--Smokefoot (talk) 15:03, 8 March 2024 (UTC)
thread_title: Split proposal