Talk:Deoxyribose

message: I think there needs to be more information available, perhaps by a link, about the chemistry and stereochemistry of sugars. It is a very important point that there are a lot of pentoses with the same chemical formula, and that ribose is the name of one particular configuration. Also, the discussion could be improved by giving readers a clue to the numbering conventions, perhaps in the diagram. The 3 and 5 positions are important too. It would even be helpful if a student could learn why and when the nomenclature for the third carbon changes from 3 to 3'.
Sugars form polymers in many ways, it is a fascinating and difficult subject area. The author here, though, seems to have in mind the particular way that ribose sugars are polymerized in nucleic acids. A crucial distinction between nucleic acid polymers and ordinary polysacharides is the 3'-5' phospho linkage. The phosphate deriviatives of ribose are not mentioned.
In discussing ribose there should be room for linkages to related important concepts such as ATP, ADP, AMP, cyclic-AMP, pyrophosphate, GTP, etc. There could also be useful links to its systhesis and metabolism. There are other scientifically important synthetic derivatives, etc.
:We're in the process of simplifying the information in the article.  --G3pro 21:45, 9 Sep 2004 (UTC)
replies: text: I believe that numbering of carbon atoms will assist reader understanding.  Such things are normally included in typical textbooks.  Also, the images presented in this, and related bio-chemistry articles, will also increase reader comprehension, especially if they show the sequence of intermediate conformations.  For instance, it is difficult for non-specialists to see how ribose can assume linear and ring formation, especially if the bonding changes are not well presented.  William R. Buckley (talk) 23:32, 13 November 2009 (UTC)
thread_title: Links needed

message: The article says that
:In contrast, very similar molecules, containing ribose instead of deoxyribose, and known generically as RNA, are only known to form relatively short double helical complementary base paired structures. These are well known, for instance, in ribosomal RNA molecules and in transfer RNA (tRNA), where so called hairpin structures form from palindromic sequences within one molecule.
RNA is certainly capable of forming double helices much longer than those found in tRNAs and rRNAs.  Double-stranded RNA viruses contain double-stranded RNAs that are thousands of basepairs long.  Pehaps there's an issue for much longer things--I don't know much about this--but I think the above is misleading. Josh Cherry 23:23, 30 Jan 2005 (UTC)
thread_title: Long Helices and RNA

message: I don't see the aldehyde (H-C=O) in the picture. Sorry??
#Might need to look at the linear version Adenosine | Talk 08:54, 26 April 2006 (UTC)
replies: text: Deoxyribose, like many sugars, intercoverts rapidly between multiple forms.  See the image labelled "Chemical equilibrium".  The middle structure has an aldehyde functional group.  -- Ed (Edgar181) 22:03, 15 January 2008 (UTC)
thread_title: Aldehyde 

message: Merge quickly, these articles should not be separated any longer! Adenosine | Talk 08:55, 26 April 2006 (UTC)
thread_title: MERGE!

message: This is not a homework question!  (although it might make a good one..  I don't know..)
Is there an accepted explanation of why the C2'-endo ring form is preferred?  I would (wildly) guess that a ring form would be preferred to a linear form because conversion from linear to ring form takes less energy than the reverse - or perhaps is exothermic.  But why it would have to do with is the 5-carbon ring preferred over the 6-carbon ring?  I'd imagine this might have to do with have two lone pairs versus one at the carbon adjacent to the oxygen, but have no idea what.
216.9.142.231 (talk) 16:57, 23 September 2011 (UTC)
thread_title:  Aqueous Solution - why is C2'-endo form preferred? 

message: Substituted at 13:14, 29 April 2016 (UTC)
thread_title: Assessment comment