Talk:Prostaglandin E2

message: I deleted:  "t has recently been discovered that, injected directly into the penis, it induces a substantial erection, even for men who have become effectively impotent."  since the prostaglandin used in "trimix" is prostaglandin e1 (Alprostadil).  While e2 may be a vasodilator, in the absence of a confirming citation, is application to erectile dysfunction is uncertain. Tachyon 18:13, 31 January 2011 (UTC)
thread_title:  older entries

message: Maybe this is jumping the gun but PGE2 looks promising as a treatment for tuberculosis. 
"Details subsequently emerged of how IL-1 normally promotes the synthesis of PGE2 by COX2, enabling macrophages to restrict M. tuberculosis growth during infection. ... PGE2 synthesis also increased alongside levels of IL-1 in the absence of type I interferon (IFN) signalling ... increasing PGE2 levels by clinically approved means enhanced the survival of M. tuberculosis-infected mice. These data ultimately provide the proof of concept that tipping the eicosanoid balance in favour of PGE2 constitutes an effective strategy against TB." Mayer-Barber, K. D. et al. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511, 99–103 (2014)  YakbutterT (talk) 19:16, 19 September 2014 (UTC)
thread_title: TB disease modulator

message: Do the group’s edits improve the article as described in the Wikipedia peer review “Guiding framework”?
Yes, this group has made edits that improve the article. They added more citations as a part of their goal, however, certain parts of the paragraph are cited from the same source after every single sentence. This needs to be condensed and represented one time after the entire paragraph if it is from the same citation. --Rmondal, UCSF (talk) 20:56, 3 August 2020 (UTC)
thread_title: Foundations II 2020 Peer Review Edits

message: To , ,   As a member of WP:WikiProject Medicine I have volunteered to watch this article while it is a Wikipedia:Wiki Ed/UCSF/Foundations II (Summer 2020) assignment. I will be creating comments here at Talk. Feel free to ask me questions in those sections or on my Talk page. David notMD (talk) 10:51, 14 August 2020 (UTC)
thread_title:  WikiProject Medicine 

message: There is no need to establish the PGE2 acronym over and over and over again! Also the article needs to be consistent throughout for the "2" in the acronym being subscripted or not. David notMD (talk) 10:24, 14 August 2020 (UTC)
thread_title:  Acronym, also, PGE2 or PGE<sub>2</sub>? 

message: Wikipedia is not supposed to be "How to". The entire Administration section should be reconsidered. David notMD (talk) 10:33, 14 August 2020 (UTC)
thread_title:  Too much "How to" 

message: This entire section should be deleted. "Society and culture" refers to how the topic of an article is mentioned/discussed/referred to outside its field. So, not information on brand names. See Birth control#Society and culture for an example. David notMD (talk) 10:38, 14 August 2020 (UTC)
replies: text: Students did not return to article, so I went ahead and deleted it. David notMD (talk) 10:07, 21 August 2020 (UTC)
thread_title:  Society and culture 

message: This should be limited to the functions of endogenous PGE2. Some drug content has been added. Also, if endogenous is covered in the article before medicinal, then the paragraphs in the Lead should be reordered. David notMD (talk) 10:42, 14 August 2020 (UTC)
thread_title:  Physiological effects section  

message: As already mentioned in the reviewers comments, Wikipedia prefers to not use "patient." David notMD (talk) 11:01, 14 August 2020 (UTC)
thread_title:  People or person, not "patient" 

message: First, kudos for refs being in a proper format. Wikipedia has a guideline on what are considered reliable sources for references for medical topics at WP:MEDRS. This includes not using in vitro or animal lit, or individual clinical trials. I believe that refs 23, 25, 31, 32 and 36 do not quality. Older refs should be replaced with newer if possible (#37). And #38 is just wrong (AGOC about caffeine). David notMD (talk) 11:10, 14 August 2020 (UTC)
replies: text: Text and non-MEDRS refs deleted. David notMD (talk) 15:46, 26 August 2020 (UTC)
thread_title:  References