Talk:Aryl hydrocarbon receptor

message: Hey so some of the information on this page may be outdated, it says that the identity of the endogenous ligand to this receptor is currently not known. I know of one such ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). Here's the article that describes its discovery: http://www.pnas.org/content/early/2010/11/09/1009201107
Here's another article talking about it's use in Nanoparticles: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396465/
Hopefully someone can go about fixing this issue, I would do it myself but I'm currently doing a project, so I don't have the time. I also don't really wanna go about fixing it and doing it incorrectly.  Quite honestly, I really just don't have time to do the citations, but here's the abstract for the first article:
An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) participates in the differentiation of FoxP3+ Treg, Tr1 cells, and IL-17–producing T cells (Th17). Most of our understanding on the role of AHR on the FoxP3+ Treg compartment results from studies using the toxic synthetic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin. Thus, the physiological relevance of AHR signaling on FoxP3+ Treg in vivo is unclear. We studied mice that carry a GFP reporter in the endogenous foxp3 locus and a mutated AHR protein with reduced affinity for its ligands, and found that AHR signaling participates in the differentiation of FoxP3+ Treg in vivo. Moreover, we found that treatment with the endogenous AHR ligand 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) given parenterally or orally induces FoxP3+ Treg that suppress experimental autoimmune encephalomyelitis. ITE acts not only on T cells, but also directly on dendritic cells to induce tolerogenic dendritic cells that support FoxP3+ Treg differentiation in a retinoic acid-dependent manner. Thus, our work demonstrates that the endogenous AHR ligand ITE promotes the induction of active immunologic tolerance by direct effects on dendritic and T cells, and identifies nontoxic endogenous AHR ligands as potential unique compounds for the treatment of autoimmune disorders.   — Preceding unsigned comment added by 98.118.113.138 (talk) 00:05, 7 April 2013 (UTC)
thread_title:  Ligand Updating 

message: I'm sorry, I have no information, I just seriously could not understand a word of that. And I'm pretty good at Chemistry... and Biology. — riana_dzasta wreak havoc|damage report  06:00, 14 September 2006 (UTC)
replies: text: That's fine. Can you give us some more information on what it is that is confusing? Do you understand the basics of transcription factors (see the linked TF article)? I realize there is a lot of jargon in the article, so maybe that turned you off. But recognize that it is a farily specific protein that is studied only by a few people, so I am not sure how non-techncial the article needs to be. What brought you to the article? Biomedeng 01:27, 30 September 2006 (UTC)
replies: text:  Wow, you know what, this is embarrassing, but I think I tagged the article very late at night when my brain was able to process very little information. As for what brought me here, I think I was removing links to a disambiguation page, and looked at this article and couldn't understand a word. I totally understand now, it's hard to baby these down too much without losing information. My apologies if that was bothering you - I'm removing the tag now :) riana_dzasta 05:14, 26 November 2006 (UTC)
thread_title:  Initial Comments 

message: Will get started on it shortly. Demantos 17:44, 11 May 2007 (UTC)
replies: text:  UB. Worked on the Protein Structure Section. Will work on others later. Demantos 18:32, 11 May 2007 (UTC)
replies: text:  Have potential subcategories defined. Demantos 19:28, 11 May 2007 (UTC)

text:  Still working on image copyrights. Demantos 19:28, 11 May 2007 (UTC)

text: Thanks for your hard work and dilligent referencing on the article. This is a tremendous improvement and I think the article may be getting close to B status. I can probably add a fair amount to the ligands section, in particular for endogenous ligands. One concern I have is that the new images on the article are from copyrighted journal articles. Are you an author of either of these articles? If not how did you go about getting permission? Biomedeng 00:59, 18 May 2007 (UTC)
replies: text:  UB. I am working on getting the Permissions now. I have permission from Annual Reviews for Image #2 and am waiting to hear back for image #1. I am not sure how to classify the images so that may need to be changed by someone who knows more. To obtain permissions, I have contacted the copyright office of each journal. Demantos 11:40, 29 May 2007 (UTC)
thread_title:  Major Editing Needed 

message: UB. All permissions have been obtained for the two images currently displayed. Written permission was obtained from the journals copyright administrator with the understanding that permission would be expressed within the figure legend. Demantos 18:38, 29 May 2007 (UTC)
thread_title:  Image Permissions 

message: Please use this tool to keep all references standardized.
http://diberri.dyndns.org/wikipedia/templates/ Make sure to check the ADD ref tag box.
Demantos 11:40, 29 May 2007 (UTC)
thread_title:  When adding references 

message: Demantos 18:40, 26 August 2007 (UTC)
thread_title:  Merge content from [[Xenobiotic Response Element]] 

message: Now that I have some more time, I'm still working on the page
UB. Demantos 13:39, 7 November 2007 (UTC)
thread_title:  Still working 

message: A good start: the facts are here and the refs are very thorough. Rewriting (not just punctuation and spelling) will improve the article significantly. 
*The article should put information into context better, so that the average reader can understand what is going on. For example: 
:*"Non-ligand bound Ahr is retained in the cytoplasm as an inactive protein complex consisting of a dimer of Hsp90 " the phrase 'Non-ligand bound' is incomprehensible to the average reader, but if I write: 
:*"When no ligands of the receptor are present, Ahr is retained in the cytoplasm as an inactive protein complex...When a ligand enters the cell and binds to the receptor, this inactive protein complex dissociates, allowing importation of the receptor into the nucleus so that it can interact with the cell's DNA." 
:*This sentence can be the lead of the paragraph or section, after which you can discuss the details. The idea is to tell the big story first so we can understand it in context, and only then can you explain the details.
*This receptor is responsible for activating the body's response to xenobiotics, right? So this should be explained clearly in the lead. 
*The opening sentence is: "The Aryl hydrocarbon receptor (AhR) is a member of the family of basic-helix-loop-helix transcription factors." Is this really the most important thing about this protein, and does it help explain the essence of the receptor to a casual reader? Consider replacing with the suggestion above.
*The lead should summarize all important aspects of the receptor, such as who discovered it and when, what the receptor's purpose is, and why scientists are still researching it. 
*There is a problem with licensing of :Image:AhR.jpg. This has a half-written fair use rationale, but a free version can be made! We can't have fair-use material if free versions can be made. In fact, I will volunteer to make a free version of this, but I'm going to tag the existing version as a copyvio. ("reprinted with permission" where is the documentation? What is the permission given, and who gave it? if permission really has been given, should have an OTRS ticket). As for :Image:AhRSignaling colour.png, I'm not entirely happy since it is almost an exact re-drawing of the original and a free version could easily be made. I'm not quite sure what to do with that one, so I'll leave it alone for now.
****I was given journal permission via email for the images used in the article.  Demantos (talk) 16:01, 3 January 2008 (UTC)
thread_title: Review by Jeff

message: The first paragraph states:
"The Aryl hydrocarbon receptor (AhR or AHR) is a member of the family of basic-helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones."
Is it not true that a transcription factor is a PROTEIN that BINDS to a RECEPTOR? If so, then why is the receptor referred to as BEING the transcription factor? It seems that this must be a mistake. 208.54.94.8 (talk) 17:06, 14 March 2009 (UTC)
thread_title:  Correction needed? - Is a receptor a transcription factor? That seems wrong. 

message: In a study published on early August 2016, AHR's presence in homo sapiens sapiens has provided this branch a much lesser susceptibility to smoke-induced diseases caused by (fireside) smoke — compared to Neanderthals and the Denisova[n] branch, who did not have AHR. This may have given a genetic advantage to what became the modern human. Article in The Guardian here. -Mardus /talk 11:01, 28 September 2016 (UTC)
thread_title:  AHR and smoke 

message: All I did was add a space, because I don't know how to ask the question, "Isn't Wikipedia supposed to be for EVERYONE to use?" Anyone who would understand this entry CLEARLY does not need to read Wikipedia for their information, since they've probably already got a PhD in organic chemistry or something. This reads like a journal article or a graduate school textbook and assumes either a VAST amount of pre-existing knowledge or a really hardcore level of motivation (to go after every linked...) 207.138.216.85
: I copied the aboved comment from this edit as I thought it was very appropriate. I edited the lead to try to make a little bit less technical. I hope this is an improvement. Boghog (talk) 19:18, 5 September 2018 (UTC)
thread_title:  Too technical