Talk:Sulfamethoxazole

message: -- Can someone take a look at the external link to the BrianDeer site?  looks a little spammy and kind of controversial in it's slant, is that site authoritative enough for this type of page?  —Preceding unsigned comment added by 72.25.192.4 (talk) 02:46, 31 December 2007 (UTC)

message: :Gone. Fvasconcellos (t·c) 14:14, 23 August 2007 (UTC)
thread_title: Untitled

message: The Structure differs from what I found during a brief research. It seems improbable having a C involved in two double bonds and one single bonds--84.148.117.73 13:51, 26 January 2006 (UTC)
replies: text: New structure uploaded. --Shaddack 21:41, 26 January 2006 (UTC)
thread_title:  Structure wrong? 

message: Does this medication have sulfer in it? Because I am allergic to sulfer medication.  —Preceding unsigned comment added by 64.138.210.141 (talk) 01:28, 24 July 2009 (UTC)
thread_title:  Question about this medication 

message: 1) verify the authenticity of information provided in the original article on sulfamethazole, specifically the introduction, side effects, and mechanism of action
2) clarify that sulfamethazole is discontinued as a drug
3) provide a more relevant overview of the drug given it is discontinued as a single drug but still being marketed and used as part of a combination drug product but without overlapping too much on the wiki entry on the combination drug Bactrim
4) provide the above information based on what intel that could be reliably found given the prescribing information for sulfamethazole us no longer attainable from the manufacturer or the FDA since it is a discontinued drug and given that paid tertiary resources like Lexi-comp and Micromedex were not acceptable for this assignment. Futhermore, we understood that compendia like Lexi-comp and Micromedex, were not original sources of drug information (since they derive much of their information usually by reinterpreting the PI) and therefore would not be the best source of information on this drug. We felt a package insert (PI) on the drug or even deriving information on the sulfamethazole API (active pharmaceutical ingredient) from the combination drug Bactrim's PI would be better since it is a primary resource or rather an original source of information. We also referenced NIH sponsored websites such as Toxnet which containing well referenced primary research and Pubchem. We also used information from a Canadian government sponsored drug database named drugbank and also double-checked if the FDA website had any additional information on sulfamethazole.
5) add a pharmacokinetics (PK) overview to the drug since PK is an important aspect of all drugs and this section was missing  — Preceding unsigned comment added by ElenaChan4 (talk • contribs) 02:01, 7 November 2015 (UTC)
thread_title:  11/4/15 The intended focus of the edits was to 

message: Here are some things to consider:
-Typo under side effects-missing an “e” in “therefore”
-Under mechanism of action, explain what bacteriostatic means? Also explain further that sulfonamides are selective for bacteria because humans don’t synthesis folate but rather absorb folate from our foods.
-Under absorption, may help to put % absorbed/bioavailability?
-Under distribution explain tmax
Hkay03 (talk) 21:28, 7 November 2015 (UTC)
thread_title:  Peer Review 

message: Thank you for you feedback. 
For the PK section:
* The term "Tmax" has updated accordingly. It is now defined as "time to reach maximum drug concentration in plasma." 
* Bioavailability data, however, has not been incorporated into this article since bioavailblity data (F) has not been found for sulfamethoxazole as a single API (active pharmaceutical agent). Although bioavailbility of sulfamethoxazole CO-FORMULATED with trimethoprim does exist as Bactrim's F, we felt using Bactrim's bioavaility data would be inaccurate for sulfamethoxazole.  — Preceding unsigned comment added by ElenaChan4 (talk • contribs) 07:35, 9 November 2015 (UTC)
thread_title:  Response to Peer Review 

message: There's a new study out in Nature Communications today that details how Streptococcus is able to develop antibiotic resistance to sulfamaethoxazole. Surprisingly, it seems that it steals the inhibited folate compounds from its host! SilverserenC 01:03, 1 December 2022 (UTC)
thread_title:  New study on resistance mechanisms 

message: 174.235.82.127 (talk) 18:03, 15 March 2024 (UTC)
thread_title:  Is it helpful with bacteria infection in your body such as endocarditis endocarditis