Talk:Dendritic cell

message: Axel,
"Dendritic cell" looks good to me, though there are 2 places where I wondered a bit:
* The article says "Dendritic cells constantly sample the surroundings for viruses and bacteria": to me, this makes dendritic cells sound 'smarter' than they are. They respond to foreign, or non-self, proteins, they don't know if it's viral or bacterial or anything other than non-self. But this may be more obscure than the way you have it.
* I don't know that I'd call helper T-cells the HIV virus's "true host": HIV infects a lot of cells, though CD-4 cells are a special target and a major means of increasing the level of infection.
As for your specific questions:
* I don't know how motile they are in tissue. I'd BET they move around a bit, but I don't KNOW that this is the case.
* the short answer is they develop from monocytes - they seem to be CD14+ monocytes.  The long answer is that this is an area of active research and the exact understanding of how dendritic cells develop is likely to change as further research is done. But I think the general idea that once a cell is a macrophage it's too late for it to become a dendritic cell is sound.  -- Someone else 22:59 Nov 18, 2002 (UTC)
Mature monocytes can differentiate into dendritic cells.  These monocyte-derived dendritic cells can be generated ex vivo by culture of macrophages with GM-CSF and IL-4.  Incidently, there is no absolute requirement for IL-4 in the generation of monocyte-derived dendritic cells.
Also, it is incorrect to imply that dendritic cells respond only to non-self proteins - they are equally capable of presenting self-epitopes, either MHC class I-restricted or MHC class II-restricted epitopes. --Sarah Morwood 21:06, 9 October 2007 (UTC)
thread_title: Untitled

message: Do you think we should split the article into sections to make it easier to read?? Also, i think we should add in which cytokines activate the dendritic cells to migrate, eg. IL-1 and TNF produced by macrophages when they encounter microbes. (REFRENCE: Basic Immunology Functions & Disorders of the Immune System 2nd Edition 2004
By AK Abbas et al.) --LowLifer 06:29, 15 October 2005 (UTC)
thread_title:  New subtitles to make the article more organized 

message: There appears to be a bug (reported) in the Wikimedia Player that returns an error when "Watch in browser" is attempted from the link in the article. However, the Watch-in-browser (Play-in-browser) feature does appear to work from the link provided on the image description page (i.e. the "(file info)" link).--DO11.10 18:37, 21 June 2007 (UTC)
thread_title:  A note about the videos 

message: Is there an article about IKDCs?  Could we get an item in ==See also== that says "IKDCs, which are not considered dendritic cells"?  WhatamIdoing (talk) 17:42, 26 April 2008 (UTC)
thread_title:  IKDCs 

message: This article is under referenced, many of the paragraphs don't have any citations. Please add citations. Aqua112233 (talk) 11:00, 21 February 2011 (UTC)
thread_title:  References Required 

message: In the whole article there is no explanation if the Plasmacytoid dendritic cells are Lymphoid  DCs. I understand that you list 3 types: mDC, pDC and FDC. If the pDC is not lymphoid DC then that should be cleared too.  — Preceding unsigned comment added by 24.248.198.18 (talk) 19:01, 15 August 2011 (UTC)
thread_title:  Plasmacytoid dendritic cell is lymphoid  dendritic cell?

message: Hello all,
I was reviewing the Dendritic cell subsets in mice and found almost no information regarding them. This is an area in which I am fairly up to date with and was hoping to expand on that section.
===Mouse (Murine)===
Murine DCs can be classified into two primary groups, plasmacytoid dendritic cells (pDCs), and the conventional dendritic cells (cDCs). Murine pDCs, are commonly characterised by the of the expression of bone stromal marker 2 which is binded by the mPDCA-1 antibody. Murine cDCs, are typically defined based off of the tissue which they are found in; lymphoid or non-lymphoid tissue, as the markers used for identification vary depending on the location of the cDCs. cDCs are commonly described by the markers CD11c, however CD11c does not unambiguously define DCs within the mouse, and the subsets can be further defined using, CD8, CD11b, CD103 antibodies.  
Also I noticed that in the page that myeloid vs plasmacytoid DCs was used as the standard demarcation between the two large divisions within dendritic cells, however in most of my readings I find that conventional DCs is much more common, could we change myeloid to conventional?
Ellemrei (talk) 18:29, 14 September 2014 (UTC)
thread_title:  Mice Dendritic Cells Subsets 

message: Murine DCs can be classified into two primary groups, plasmacytoid dendritic cells (pDCs), and the conventional dendritic cells (cDCs). Murine pDCs, are commonly characterised by the of the expression of bone stromal marker 2 which is binded by the mPDCA-1 antibody. Murine cDCs, are typically defined based off of the tissue which they are found in; lymphoid or non-lymphoid tissue, as the markers used for identification vary depending on the location of the cDCs. cDCs are commonly described by the markers CD11c, however CD11c does not unambiguously define DCs within the mouse, and the subsets can be further defined using, CD8, CD11b, CD103 antibodies.  
Also I noticed that in the page that myeloid vs plasmacytoid DCs was used as the standard demarcation between the two large divisions within dendritic cells, however in most of my readings I find that conventional DCs is much more common, could we change myeloid to conventional?
Ellemrei (talk) 18:29, 14 September 2014 (UTC)
thread_title: Mouse (Murine)

message: Substituted at 13:12, 29 April 2016 (UTC)
thread_title: Assessment comment