Talk:Long QT syndrome

message: Genetic testing was discussed in JAMA on 21 Dec 05. JFW | T@lk 21:55, 22 December 2005 (UTC)
thread_title:  Genetic Testing 

message: Side effect of anti-psychotics based on PI sheets for Haldol and Geodon. John Elder 02:17, 28 March 2006 (UTC)
thread_title:  Side effect of anti-psychotics 

message: Left Cardiac Sympathetic Denervation is absent from the article.   — C M B J   22:44, 17 December 2008 (UTC)
thread_title:  Left Cardiac Sympathetic Denervation 

message: I have removed a long list (unsourced) with conditions and states in which the QTc interval may be prolonged. They don't belong in this article, because they are not "syndromal". They need to be discussed in another article, either about QTc prolongation or TDP.
More common than the various congenital causes of long QT syndrome are acquired causes. They can be divided into two main categories - those due to disturbances in blood electrolytes and those due to various drugs:
*electrolyte disorders
**hypokalemia
**hypomagnesemia
**hypocalcemia
*drug-induced
**Antiarrhythmic drugs
***Quinidine
***Amiodarone 
***Sotalol  
***Procainamide
***Ranolazine
**Antihistamines
***terfenadine
***astemizole 
**Antibiotics
***Macrolide 
****Erythromycin
*** Certain Fluoroquinolone antibiotics
****Moxifloxacin 
**Major tranquilizers (i.e. antipsychotics)
***Chlorpromazine
***Haloperidol
**Tricyclic antidepressants
**Gastrointestinal Motility agents
***Cisapride
***Domperidone
**Antipsychotic drugs
***Haloperidol 
***Quetiapine
***Thioridazine 
***Droperidol 
**Analgesics
***Methadone
***LAAM''
Just as with the congenital causes of the Long QT syndrome, the acquired causes may also lead to the potentially lethal arrythmia known as Torsade de Pointes. Treatment is straightforward - replace any deficient electrolytes if present and stop any culprit drugs if the patient is using one (or more). 
Given its relatively high frequency of use, its tendency for drug-drug interaction, and its inherent ability to prolong the QT interval, the macrolide antibiotic erythromycin is probably the most prevalent cause of acquired long QT syndrome. Indeed, use of erythromycin is associated with a rate of death more than double that of use of other antibiotics
In addition to the two major categories listed above, it should be noted that there are also some miscellaneous causes of QT prolongation such as anorexia nervosa, hypothyroidism, HIV infection, and myocardial infarction.
Hope this is OK. 
-- JFW | T@lk 14:59, 14 February 2010 (UTC)
replies: text: QT interval sounds like the right place. JFW | T@lk 15:15, 14 February 2010 (UTC)
thread_title:  Non-genetic causes 

message: NEJM covered this in 2008  JFW | T@lk 12:53, 6 March 2011 (UTC)
thread_title:  NEJM 2008 

message: could there be added a comparison picture of what a LQT looks like  —Preceding unsigned comment added by 71.112.216.33 (talk) 17:08, 23 March 2011 (UTC)
thread_title:  Comparison Picture 

message: What about using primidone as a treatment. It is mentioned in the primidone article that it has been used for this purpose.
AriaNo11 (talk) 18:11, 28 April 2011 (UTC)
replies: text: Have a source for that? JFW | T@lk 20:18, 28 April 2011 (UTC)
thread_title:  treatment 

message: It states that the use of potassium as a potential treatment is not evidence-based - I can understand this, but doesn't reference even an anecdotal reports of long QT going into remission after potassium supplementation, and/or in vitro studies of the effect of K supplementation on the functions of the various ion channels.  I find it hard to believe there isn't *any* evidence whatsoever.  — Preceding unsigned comment added by 98.223.232.121 (talk) 18:16, 30 January 2012 (UTC)
thread_title:  Potassium supplementation as a treatment - *no* evidence? 

message: Hi Editors,
Checked on citation #13, Challenges of Diagnosis of Long-QT Syndrome in Children, this article does not support the claim made, nor is the claim cited within the article, appears to be a mistaken citation.  — Preceding unsigned comment added by 152.132.10.133 (talk) 18:41, 4 September 2015 (UTC)
thread_title:  Inappropriate citation 

message: The language here is fairly technical and given without context, and I believe it should be marked.learnergenius (talk) 03:58, 2 February 2017 (UTC)
thread_title:  Too technical? 

message: The link in reference #2 is broken. Here's a link that works, but I don't know how to update it in the article. http://www.mdedge.com/ccjm/article/94949/cardiology/congenital-long-qt-syndrome-considerations-primary-care-physicians  — Preceding unsigned comment added by Trogyssy (talk • contribs) 16:21, 15 February 2017 (UTC)
replies: text: fixed Jytdog (talk) 21:08, 15 February 2017 (UTC)
thread_title:  Broken reference 

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thread_title:  External links modified 

message: There is a review on the topic and we summarize it already as "Mental stress or physical exertion may trigger arrhythmia in some people with LQTS."
No need for all the primary sources. Just to repeat what the review has said. Doc James (talk · contribs · email) 10:54, 24 December 2018 (UTC)
thread_title: Stress

message: The causes section as it stands is a bit of a mess.  Causes is currently divided into Acquired and Genetics, with genetics being split into 16 subheadings of LQT1 through LQT16, all of which is pretty intimidating and difficult to read.  Some of this could be condensed with "Main Article:" links to the relevant subtypes. 
How about this for a proposed re-organisation:
*Acquired
*Congenital
*Initial description of main genetic forms with the current genetics table followed by subheadings of
:*Romano ward syndrome (Focus on LQT1-3 with mention of other forms, detail could be shunted to Romano-Ward article)
:*Jervell-Lange-Nielsen syndrome
:*Andersen-Tawil syndrome
:*Timothy syndrome
If there are no dissenting views I'll aim to do this (at some point). PeaBrainC (talk) 16:02, 16 June 2019 (UTC)
replies: text: Sounds great. I do wonder how to best communicate the interaction between congenital and acquired causes. JFW | T@lk 16:27, 16 June 2019 (UTC)
thread_title:  Organisation of causes section