Talk:Chronic granulomatous disease

message: Expanced article...please contact me with any suggestions, questions, or comments.--Jfurr1981 04:14, 16 September 2006 (UTC)
thread_title:  older entries 

message: The following sentence could be reworded for clarity:
* X-linked Chronic Granulomatous disease: defect in membrane NADPH oxidase. Autosomal Recessive Chronic Granulomatous disease: defect in cytoplasmic NADPH oxidase.
In the news article it says that 3 people were recruited to the gene therapy trial, the article says 2. --apers0n 15:22, 16 September 2006 (UTC)
thread_title:  Comments 

message: Reworked the genetics and therapy (specifically gene therapy) sections, added external links and an infobox, and added a reference for the NBT test.  Thanks for the input AspersOn and NCurse.Jfurr1981 13:25, 17 September 2006 (UTC)
thread_title: Re: Suggestions

message: My suggestions:
* "CGD affects about 1 in 200,000 people in the United States, with at least 20 new cases diagnosed each year." (a reference would be useful)
*: Fixed. 
* section Genetics: :Image:X-link dominant father.jpg, :Image:XlinkRecessive.jpg, :Image:Xlink dominant mother.jpg?
*: Added pictures.
* "A low level of NADPH, the cofactor required for superoxide synthesis, can lead to CGD. This has been reported in women who are homozygous for the genetic defect causing glucose-6-phosphate dehydrogenase deficiency (G6PD), which is characterised by reduced NADPH levels." (reference?)
*: Can't find source for the whole cite but both lines are mentioned throughout the literature.
* "Thus, CGD should be considered as a diagnosis in patients with an Aspergillus infection whose cause in unknown." (reference?)
*: Removed.
* a cytochrome C reduction assay reference would be useful too
*: Unnecessary, this part is understandable in its own.
Anyway great article! NCurse  work 17:20, 17 September 2006 (UTC)
replies: text: Thanks for the help. :) NCurse  work 11:31, 28 September 2006 (UTC)
thread_title:  Good article nomination 

message: After re-reviewing the article and adding the necessary stuff requested by NCurse, it compares with the GA criteria by passing all of them. It might not be a long article but it covers the most important topics for now. An expansion would still be of use but it is a good article after all. Lincher 02:29, 28 September 2006 (UTC)
replies: text: Thanks for the help. :) NCurse  work 11:31, 28 September 2006 (UTC)
thread_title: GA awarded

message: Phagocytes (i.e., neutrophils, monocytes, and macrophages) require an enzyme to produce reactive oxygen species to destroy bacteria after they ingest the bacteria in a process called phagocytosis. This enzyme is termed "phagocyte NADPH oxidase" (PHOX)
- I googled a little and find mentions of either NADPH oxidase complex or of phagocyte oxidase (PHOX) subinits of this complex. Maybe there's a little mistake here. Best regards, CopperKettle (talk) 13:54, 14 December 2007 (UTC)
thread_title:  phagocyte NADPH oxidase - or [[NADPH oxidase]] complex containing several PHOX'es? 

message: This figure seemed to clutter the page and confuse the discussion of CGD.  It is enough to have an internal link to the sex linkage page which has the same table (now that I put it there in its entirety).  This leaves room to discuss CGD.  If people want to know about the genetic probabilities of sex linkage, then they can click through to that page.  Mba123 (talk) 20:44, 17 May 2009 (UTC)
thread_title:  X-linkage figure 

message: Not broad enough in scope to be GA.
  
#Needs the section on epidemiology expanded as well as history.  
#As needs a discussion of classification.  
#Uptodate says "Hematopoietic cell transplantation — Successful hematopoietic cell transplantation (HCT) is a definitive cure for CGD. While outcomes may be better in younger patients with less CGD sequelae, HCT may be more useful in patients with recurrent serious infections despite prophylaxis and/or severe, difficult to treat, inflammatory disease."  We do not discuss it yet.
--Doc James (talk · contribs · email) 03:54, 31 May 2009 (UTC)
thread_title: GA

message: This blood smear displays two hypersegmented neutrophils, which are prototypical for defects in DNA replication (vitamin B12 deficiency, folate deficiency, orotic aciduria, methotrexate therapy, etc...).  They are not seen in CGD.  With that in mind, it might be a good idea to employ a picture of regular neutrophils in its place.  — Preceding unsigned comment added by 147.140.127.133 (talk) 17:16, 19 June 2011 (UTC)
thread_title:  Image under "Pathophysiology" heading 

message: I've been approached on Facebook and my talk page by , who wished to discuss certain sources that she had hoped to include. I reverted this addition a while ago, so perhaps we should discuss here whether they are suitable. Opinions appreciated. JFW | T@lk 20:11, 21 November 2015 (UTC)
thread_title:  Sources 

message: Thank you . As a member of the CGD community, I am interested in feedback regarding including a reference to the Immune Deficiency Foundation, which is the largest organization in the the U.S. that represents CGD. It publishes several books on CGD, holds the largest conferences and meetings for the CGD community globally, and works with the leading researchers, doctors, and experts at the National Institutes of Health to publish information regarding CGD, such as: https://primaryimmune.org/wp-content/uploads/2013/06/ClinicalFocus_2013.pdf Also, IDF is listed here, as a reference in this NIH online publication
http://www.ncbi.nlm.nih.gov/books/NBK99496/ 
Also, would like to discuss your thoughts on including the following recent studies and references regarding prognosis:
Recent experience from centers specializing in the care of patients with CGD suggests that the current mortality has fallen to under 3% and 1% respectively.
Source:  Modern Management of Chronic Granulomatous Disease by Reinhard Segar, Division of Immunology/Hematology, University Children’s Hospital of Zurich, Zurich, Switerland
CGD was initially termed "fatal granulomatous disease of childhood" because patients rarely survived past their first decade in the time before routine use of prophylactic antimicrobial agents. The average patient now survives at least 40 years.
Source: http://www.uptodate.com/contents/chronic-granulomatous-disease-treatment-and-prognosis
Look forward to your feedback.  Thanks 
Elliedee (talk) 01:51, 24 November 2015 (UTC)
thread_title:  CGD