Talk:Porphyria

message: Is this article showing a bug in MidiaWiki?
The link to George III shows red when looking at the article, but when doing a diff or a preview it looks right.
--KayEss 16:15, 16 Oct 2004 (UTC)
thread_title:  older entries 

message: Someone added Frederick William II of Prussia as a porphyria sufferer. Google had virtually nothing compared to George III, so I've removed this as distant speculation. JFW | T@lk 06:50, 4 August 2005 (UTC)
thread_title:  Frederick William II of Prussia 

message: The article could still do with some epidemiology, prognosis and complications. I've been expanding piecemeal but am a bit hesitant to continue, as I have nil clinical experience with this condition. Does anyone else have experience with this? JFW | T@lk 19:58, 26 September 2005 (UTC)
thread_title:  Request for expansion 

message: Out of the 8 enzymes listed in the Heme biosynthetic pathway, it is stated that the first and last 3 are in the mitochondria and the remaining 4 (????) are in the cytosol... Does anybody know what the truth is? I will research it, but if someone knows offhand please correct at will...
Cheers
:See diagram on Porphyrin#In_brief. JFW | T@lk 08:32, 6 November 2005 (UTC)
thread_title:  Enzyme location 

message: I know people with this disease.. they drink blood, then want and as they say, they "need" blood... they cannot be on sun for long time and they are allergic for gold. This people are from Prague.
I think you know vampire-wanna-bes, not real sufferers of the illness.
:Are you a vampire troll? JFW | T@lk 08:19, 3 September 2006 (UTC)
thread_title:  I know... 

message: This study again confirms that hemin is good in acute porphyria. JFW | T@lk 08:19, 3 September 2006 (UTC)
thread_title: Lipids

message: I have been informed that Google does not return any results as Porphyric Haemophilia being another term for Porphyria. While this is true, we can also say that Google is not infallible. In the 1950's, Porphyria (especially Hepatic Porphyria) was sometimes referred to as "Porphyric Haemophilia", based on the way that blood injections were occasionally used to temporarily stabilize the afflicted person. While the diesease is not in reality a Haemophilia at all, this term was used in error for lack of understanding of the disease, especially in a book I have a copy of, "An Encyclopaedia of Obscure Medicine" by Joness Denver, Published by University Books, Inc., 1959. 
This, because of the use of this term in Morrowind, is why I added the Disambig at the top. Thank you for your time. ~  Porphyric Hemophiliac § 00:38, 8 September 2006 (UTC)
thread_title: In reference to my edit 

message: I've finally managed to weed out the piles of anecdotal crud once inserted by a porphyrophiliac anonymous editor. What it is now is all that I know about this condition; I will try to reread the Kauppinen review and update the article accordingly.
This article apparently sheds some light (no pun intended) on the history of porphyria. I'll need to locate fulltext with the help of our nice librarians. JFW | T@lk 21:45, 18 October 2006 (UTC)
thread_title:  Working 

message: Apparently, someone vandalized the Porphyria page by erasing the entire page, and putting "I LOVE PIE!!!!" and a bunch of non-Latin symbols. I undid the changes and I would like to cite the last user for vandalism. They were logged in. Someone please check the history for me. 
Geosultan4 02:52, 6 March 2007 (UTC)
thread_title:  Recent Vandalism 

message: I agree that the case for vampirism being explained by a porphyria does not stack up because drinking blood would not correct the associated anaemia as previously mentioned .. in fact it could conceivably lead to iron overload.
The werewolf legends do fit better ....consider for example persons with Congenital erythropoetic porphyria which goes untreated ....this could lead to 
a)loss of mental competence(possibly leading to odd behaviour and vocalisations)
b)hypertrichosis
c)Severe photosensitivity so sufferers would only come out at night and may have developed an otherwise odd appearance due to light evoked scarring.
d)Fluorescent red/brown teeth ( presumably best seen at night under a full moon!)
One can envisage a situation in isolated communities in densly forrested areas where consanguinity has increased the likelihood of this autosomal recessive condition occuring.
all speculative of course but certainly worth consideration ...
Doctorpete 11:06, 24 May 2007 (UTC)
replies: text: 206.217.11.124 (talk) 12:17, 26 October 2009 (UTC)
thread_title:  Werewolf Legends 

message: Personally I'm not sure how to handle the edit for this since I have infact read such criticisms elsewhere and in books.
The article states "The theory also operates on a highly-flawed premise: mainly in regards to a perceived harmful effect sunlight had on vampires. But this is a much more recent innovation in vampire "lore": its origin is from 1922, with the release of vampire movie, Nosferatu, eine Symphonie des Grauens."
However, in Bram Stoker's original Dracula novel published in 1897, the vampire, Dracula, was infact affected by sunlight. His powers were much weaker and he was very vulnerable in sunlight. It didn't kill him, but it was in a sense his kryptonite. Also, there's a prevailing tradition that vampires only come out at night extending as far back as a time when vampires were thought to be merely evil spirits the possess both animate and inanimate things. Anything from a rabid dog to a rusty door latch could be seen as a vampire at one point.
If need be, I can dig out my books from storage to provide citations for this, but it'll take some time. Still, the statement is obviously flawed as anyone who's read Bram Stoker's Dracula will know, 1922 wasn't the start of sunlight being harmful. If anything, it's "Nosferatu" started the sunlight is lethal bit. Even then, historically speaking, Nosferatu and Vampires were two entirely different things.  —Preceding unsigned comment added by 24.254.163.150 (talk) 19:33, 24 July 2008 (UTC)
replies: text: You are correct. If people would just use their heads. In the original Vampire legends, FAR before Bram wrote his book, They would dig up the recently buried corpse of a person to see if they were a Vampire. This had to do with them looking for the body to be bloated with blood around the mouth. Their belief was that the "Vampire" was only active AT NIGHT, and would FEED on sleeping people. Last time I checked, people sleep at night and in order to be in a defenseless state, you either have to be drugged/drunk or asleep. Again the majority of the population slept at night. They dug them up during the day time, then put a stake in them to hold them down. Again, I would like to point out that I have this stupid illness, and I in no way, so far, have had ANY urge to drink blood in ANY way. TheСyndicate 18:46, 2 November 2008 (UTC)
thread_title:  False statement. 

message: The following book would appear to be a suitable source for the speculation that members of the Royal family had porphyria. I've only read the reviews, which indicate it specifies several names that are currently unsourced in this article, and the reviews seem to regard it as a serious work. Colin°Talk 10:11, 1 February 2009 (UTC)
thread_title:  Royal family 

message: I would like to suggest possible treatment for ALAD porphyria. I was thinking that Lead poisoning causes the same symptoms and probably has had alot more research. I looked up how to treat lead poisoning and it's suggested chelation therapy and vitamin C. I mean, that's something to think about. We really need more research of ALAD and other porphyrias too. Interestedperson (talk) 02:57, 9 February 2009 (UTC)
thread_title: ALAD porphyria

message: On July 15 2008, the article stated that Mary QoS was George III's "grandmother six times removed" – a phrase I do not understand. I looked up the relationship, and edited this to read "first cousin nine times removed". Recently, someone changed this to "great great great great great grandmother", and someone else changed it back.
Today I checked the relationship, and found that "great great great great great grandmother" is in fact correct. I do not know why I got it wrong first time – I guess I followed a different line of relationship. The direct one goes through Sophia of Hanover, great granddaughter of Mary and great great grandmother of George III. I have corrected the article. I offer my apologies to those whom I misled. Maproom (talk) 19:09, 11 March 2009 (UTC)
thread_title: Relationship between Mary Queen of Scots and George III

message: Just for the record I do not know of any person with Variegate Porphyria with developmental delay and I should know we have 24 sufferers in our family and absolutely no one has any form of developmental delay as a matter of fact they all are highly intelligent from an early age.  There is serious problems with this article maybe some one who is a porphyria specialist should edit this page fully. 
Thank you  —Preceding unsigned comment added by 69.176.161.35 (talk) 06:45, 26 March 2009 (UTC)
thread_title:  Serious errors 

message: Sincerely I cannot find this book/article anywhere, not even in official David Dolphin's bibiography.  —Preceding unsigned comment added by 81.186.232.30 (talk) 19:10, 30 March 2009 (UTC)
thread_title:  Porphyria, Vampires, and Werewolves: The Aetiology of European Metamorphosis Legends 

message: In the chapter "Signs and symptoms" the Porphyria cutanea tarda (PCT) is reported as acute, but is non acute, and the "ALA Dehydratase Deficiency" is missed within the acute types. Also the links acute-->hepatic and cutaneous-->erythropoietic in the preamble and the subsequent division seems wrong (as far as I know the correct subdivision is "acute" and "non acute")
Unfortunately I'm not an expert, therefore I don't feel confortable in modifying this page and I prefer somene else to do it.
Jimmi61 (talk) 09:54, 27 November 2009 (UTC)
thread_title:  Error in porphyria types classification 

message: In the current issue of “The Psychologist” magazine, Peter Garrard, Reader in Neurology the University of Southampton, writes:
:“Thanks to a widely publicised series of articles by psychiatrists Ida MacAlpine and Richard Hunter (1966), it has become widely accepted that King George’s bizarre behaviour was due to acute exacerbations of the inherited metabolic illness porphyria. An exhaustive analysis of historical records, however, has revealed that this claim was based on spurious and selective interpretation of contemporary medical and historical sources (Peters & Wilkinson, in press).”- Garrard, P., (2010), “Literature, history and biology”, The Psychologist, Vol 23, No 3, March 2010, pp 262-263. Martinevans123 (talk) 13:26, 23 March 2010 (UTC)
replies: text: The reference, now published, is this: Peters, Timothy J.; Wilkinson, D. (2010) "King George III and porphyria: a clinical re-examination of the historical evidence", History of Psychiatry 21: 3–19. Martinevans123 (talk) 22:29, 23 March 2010 (UTC)
thread_title:  [[George III]] 

message: Could someone upload an humann image of porphyria showing the skin lesions and perhaps one of discoloured urine. These would add a lot of value to the article - the paintings of kings and queens add little I'm afraid.ROxBo (talk) 05:12, 28 May 2010 (UTC)
thread_title: Images

message: I think there needs to be some purple poo and pee.  —Preceding unsigned comment added by 71.17.167.191 (talk) 10:37, 1 March 2011 (UTC)
thread_title:  pictures needed 

message: doi:10.1016/S0738-081X(97)00199-5 - Goldberg's history 1998, Clin Derm. JFW | T@lk 03:30, 30 May 2011 (UTC)
thread_title:  History 

message: doi:10.1182/blood-2012-05-423186 is a recent review. JFW | T@lk 10:01, 2 December 2012 (UTC)
replies: text: British/Irish national guidelines (http://bipnet.org.uk/index.php/bipnet-clinical-guidelines/management-of-acute-porphyria.html). JFW | T@lk 15:09, 10 January 2013 (UTC)

text: Case series (108 pts) - diagnostic delay can be a decade doi:10.1016/j.amjmed.2014.06.036. Needs a secondary source for backup, but very illustrative... JFW | T@lk 09:05, 4 December 2014 (UTC)
thread_title:  Review in Blood 

message: doi:10.1111/bjh.14459 JFW | T@lk 16:06, 22 February 2017 (UTC)
thread_title:  Updated review 

message: This text was added "The most frequent type of porphyria is porphyria cutanea tarda (PCT), which manifests solely with skin complaints and is usually sporadic."
Ref however says "Most porphyrias are inherited disorders"... "For example, porphyria cutanea tarda is most common in the United States, and variegate porphyria is most common in South America."..."Porphyria cutanea tarda is usually an acquired disorder"
So it is not saying that PCT is the most common globally. Doc James (talk · contribs · email) 20:03, 26 August 2017 (UTC)
replies: text: Sorry, I assumed the refs would be comprehensive, I shouldn't have. Here are three sources that do say it is the most common:
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820519/
* https://www.ncbi.nlm.nih.gov/pubmed/18093456
* https://www.ncbi.nlm.nih.gov/pubmed/28321838
As for hypertension and tachycardia as manifestations of acute attacks here are two sources:
* http://emedicine.medscape.com/article/957604-clinical#showall
* https://www.ncbi.nlm.nih.gov/pubmed/27982422
Fuse809 (contribs · email · talk · uploads) 07:49, 27 August 2017 (UTC)
replies: text: This references looks good https://www.ncbi.nlm.nih.gov/pubmed/?term=27982422 Doc James (talk · contribs · email) 08:06, 27 August 2017 (UTC)
thread_title: Text

message: doi:10.1056/NEJMra1608634 JFW | T@lk 08:51, 31 August 2017 (UTC)
thread_title:  NEJM