Talk:Cyclodextrin

message: * The info dealing with the topological positioning of the hydroxyl groups within cyclodextrins was removed by a user with ip 137.43.156.123 in the revision of 20:10, 26 October 2005, maybe because such data was somewhat confusing. However I think this information is quite important to understand why cyclodextrins show their particular complexing capacity: for this reason I decided to put it back into the Structure section in what is hopefully a bit more clear fashion. If anyone has suggestions as to how to simplify the concept, modifications are welcome. Berserker79 13:05, 3 November 2005 (UTC)
thread_title:  Cyclodextrin topology 

message: * I'd like to suggest to update the chemical structure to reflect the correct axial and equatorial orientations of the 2-, 3- and 6-hydroxy groups in each glucose unit. I know this probably requires a redraw of the really nice graphic. However, since the inherent chirality of cyclodextrins is of importance as is the stereochemistry of sugars, this update appears to be desirable. Kajjo, 25. Jan 06
* I'll try to redraw the cyclodextrins picture in the next days to include the suggested details: that could also help clarify the statament about the molecule topology. Don't know when it will be ready however. Berserker79 12:46, 27 January 2006 (UTC)
thread_title:  Chemical Structure 

message: * This sentence needs rewording: "Recently, the largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, even at least 150-membered cyclic oligosaccharides are also known."
:That is just one example of many, the quality of the English in this article is quite dire and needs a major overhaul Azo bob (talk) 08:55, 19 May 2008 (UTC)
thread_title:  Sentence needs rewording 

message: * Another sentence that needs rephrasing: "The production of cyclodextrins is relatively simple and involves treatment of ordinary starch with a set of easily available enzymes." I'm unaware that you can just walk into a store and buy the enzymes that are mentioned after this sentence. It sounds like they'd only be available to certain institutions that have the right connections.  — Preceding unsigned comment added by 174.101.198.62 (talk) 04:10, 16 October 2013 (UTC)
thread_title:  "Easily" available to whom? 

message: This page is full of good information but is sadly lacking when it comes to specific references.  M stone 04:05, 2 August 2007 (UTC)
thread_title: References needed

message: Shu, Zeng, Wang, Covey, Zorumski, Mennerick
Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions
Br J Pharmacol. 2007 January; 150(2): 164–175.
Published online 2006 December 11. doi:  10.1038/sj.bjp.0706973
:[C]yclodextrins form inclusion complexes with at least some steroids that are active at the GABA(A) receptor, such as (3alpha,5alpha)-3-hydroxypregnan-20-one (3alpha5alphaP, allopregnanolone). ... gamma-cyclodextrins can be useful, albeit non-specific, tools for terminating the actions of multiple classes of naturally occurring neuroactive steroids.     
  — Preceding unsigned comment added by 99.190.133.143 (talk) 17:59, 22 April 2012 (UTC)
thread_title:  Brain effects 

message: Captisol® is a patent protected, uniquely modified cyclodextrin, whose chemical structure was rationally designed to maximize safety and optimize interaction to improve the solubility, stability, bioavailability or lessen volatility, irritation, smell or taste.
Captisol® is a patent protected, uniquely modified cyclodextrin, whose chemical structure was rationally designed to maximize safety...
Captisol® is a polyanionic beta-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether (SBE). Captisol® is not a single chemical species, but comprised of a multitude of polymeric structures of varying degrees of substitution and positional/regional isomers dictated and controlled to a uniform pattern by a patented manufacturing process consistently practiced and improved to control impurities.
The selection of Captisol® and its desirable safety profile and drug solubilization properties was based upon extensive evaluations of the mono, tetra and hepta-substituted dominated compositions. Captisol® is the trade name for Ligand's modified beta-cyclodextrin technology.
Several hundred of pre-clinical and clinical studies have been performed and indicate that Captisol® is safe when administered parenterally or orally and does not exhibit the nephrotoxicity associated with beta-cyclodextrin. Relative to beta-cyclodextrin, Captisol® provides higher interaction characteristics and superior water solubility in excess of 100 grams/100 ml – a 50-fold improvement.
Could any of the above be added as a specific sub-type cyclodextrin of the beta type. It seems if the above doesn't display the nephrotoxic effects usual to the beta class to which it belongs, that it's particular subtype would be note worthy enough for at least mention in a section of this article page. 71.32.253.184 (talk) 06:09, 28 May 2012 (UTC)
replies: text: That seems too highly promotional to me.  It would have to be rephrased to be added.  -- Ed (Edgar181) 11:11, 3 July 2013 (UTC)
thread_title:  SBE-β-CD / SBE beta  cyclodextrins (e.g. Captisol) 

message: In mice fed high-cholesterol diets, cyclodextrin cleared away plaques and helped prevent more plaques from forming, Latz and his colleagues found. The chemical also activated cholesterol metabolism that boosted clearance of the waxy substance from arteries, plus dampened inflammation responses that spur atherosclerosis.
Using blood vessel tissue from human patients with atherosclerosis, researchers found that cyclodextrin induced the same changes in the human cells as it did in the mice.
The study shows that cyclodextrin is a promising new treatment for atherosclerosis in humans.
Science Translational Medicine, 2015. DOI: 10.1126/scitranslmed.aad6100
 Mike dill (talk) 05:28, 9 April 2016 (UTC)
replies: text: How was the cyclodextrin administered to those atherosclerotic mice: orally? subcutaneously? IV? parenterally? Please add that to the article.
Phantom in ca (talk) 18:59, 10 April 2016 (UTC)
thread_title:  Research: Cyclodextrin clears cholesterol plaques, etc. 

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thread_title:  External links modified