Talk:Hypericum perforatum

message: In Sweden, and I presume other countries, St John's Wroth is used to flavor "Brännvin", i.e. har liquor, to make a blood-red colored snaps. This page does only discuss it's medicinal use, and it's effect on the ecology of various places. There's a lot of "rules" as how to pick the buds (as, according to the enthusiast only the bugs are good for flavoring), e.g. they shall be picked on a warm dry day, after 6 pm o' clock, one mustn't touch the buds with one's fingers as that will release hypericin (it's supposed to be saved for the liquor), etc. etc. While it may be a niche field, it's certainly the most common use for St John's worth by ordinary people (whom rarely make herbal supplements at home, I guess).  — Preceding unsigned comment added by 155.4.129.166 (talk) 14:51, 25 June 2016 (UTC)
thread_title:  Use as liquor flavoring 

message: Hello Page Owners/Experts,
As a common reader to this page, I wish to highlight some text that appeared to me to be in contradiction with the pages on 3A4/2C9. 
First the quote:
Pharmacokinetic interactions
St John's wort has been shown to cause multiple drug interactions through induction of the cytochrome P450 enzymes CYP3A4 and CYP2C9, and CYP1A2 (females only). This drug-metabolizing enzyme induction results in the increased metabolism of certain drugs, leading to decreased plasma concentration and potential clinical effect.
So, here is my concern:
If I read this quote on its own, my conclusion would be that SJW induces CYP3A4 and CYP2C9https://en.wikipedia.org/wiki/Hypericum_perforatum. i.e. Both. However, if I read on the pages for CYP3A4https://en.wikipedia.org/wiki/CYP3A4 and CYP2C9https://en.wikipedia.org/wiki/CYP2C9, it appears to me that SJW induces 3A4 but inhibits 2C9. i.e. I have noticed an apparent contradiction.
Please take a look, and fix or clarify as appropriate.
Thanks!
Simple in ca (talk) 03:08, 12 November 2015 (UTC)
replies: text: Well, the source given says nothing about CYP2C9, so I removed the reference to this in the article. Peter coxhead (talk) 11:57, 12 November 2015 (UTC)
thread_title:  Pharmacokinetic Interactions 

message: Hello fellow Wikipedians,
I have just modified  on Hypericum perforatum. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive http://web.archive.org/web/20150226011121/http://www.northwestweeds.com.au:80/st_johns_wort.htm to http://www.northwestweeds.com.au/st_johns_wort.htm#effect_on_animals
*Added archive http://web.archive.org/web/20140921033429/http://pubchem.ncbi.nlm.nih.gov:80/summary/summary.cgi? to http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
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*http://web.archive.org/web/20150226011121/http://www.northwestweeds.com.au:80/st_johns_wort.htm
*http://web.archive.org/web/20140921033429/http://pubchem.ncbi.nlm.nih.gov:80/summary/summary.cgi?
Cheers.—InternetArchiveBot (Report bug) 12:10, 21 July 2016 (UTC)
thread_title:  External links modified 

message: I refer to my undo earlier today. My reading of the intent of the sentence was that the problem occurred above 24 degrees at a particular time during the plants annual cycle, ie mid-summer, due to certain biological conditions. The problems would not occur in, say, autumn (even though that would presumably be not relevant because the mid summer temp would presumably also be above 24 degrees if the autumn temp was too. It seemed to me the reference to the southern hempishere was clumsy and the then editor had just copied a reference from a book published in the southern hemisphere. But, i'm no plant expert. I'm better with grammar and sentences. Roger 8 Roger (talk) 18:45, 6 November 2016 (UTC)
thread_title:  Daily Mean Temperature 

message: Hello fellow Wikipedians,
I have just modified 4 external links on Hypericum perforatum. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Corrected formatting/usage for http://www.bsbi.org.uk/BSBIList2007.xls
*Added archive https://web.archive.org/web/20131005011912/http://www.benthamscience.com/cpd/sample/cpd11-2/0007B.pdf to http://www.benthamscience.com/cpd/sample/cpd11-2/0007B.pdf
*Added archive https://web.archive.org/web/20131216111409/http://lib.kums.ac.ir/documents/10129/71808/334.pdf to http://lib.kums.ac.ir/documents/10129/71808/334.pdf
*Added archive https://web.archive.org/web/20140611050347/http://sites.duke.edu/greesonlab/files/2011/07/Greeson_etal_2001_Psychopharm-St.-Johns-Wort.pdf to http://sites.duke.edu/greesonlab/files/2011/07/Greeson_etal_2001_Psychopharm-St.-Johns-Wort.pdf
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Cheers.—InternetArchiveBot (Report bug) 04:54, 7 December 2017 (UTC)
thread_title:  External links modified 

message: Removed this mess as primary, mostly outdated, in vitro research as WP:PRIMARY, leading to a host of unwarranted speculation about what effects may exist in vivo. Needs WP:MEDRS reviews, which evidently do not exist. --Zefr (talk) 01:00, 22 August 2018 (UTC)
replies: text: Hi, I noticed your similar changeset in Hyperforin and thought it was perhaps a bit overzealous (see the talk page). Any chance some of it could stay? I think it'd be a terrible shame if all of it would have to stay removed. – Erik.Bjareholt (talk) 09:28, 12 September 2018 (UTC)
thread_title:  In vitro research 

message: The answer depends on WP:Engvar. St is correct in British English usage and St. is correct in American English usage. The article adopted St right from the start. Plantsurfer 19:08, 28 November 2019 (UTC)
thread_title: St. or St ?

message: There has been a couple of recent reverts of an edit to replace a small number, and hence inconsistent, uses of ‘St.’ with ‘St’. Reasons the latter should be used:
*’St’ is the recognised abbreviated form, although arguable a contraction. (See )
*‘St’ has always been the dominant usage in the article.
*‘St’ was used in the earliest version of the article (see   — Preceding unsigned comment added by 2A00:23C5:9313:B900:8EC:49AE:48DC:741F (talk) 19:16, 28 November 2019 (UTC)
thread_title:  St not St. 

message: The following Wikimedia Commons file used on this page or its Wikidata item has been nominated for deletion:
* 
Participate in the deletion discussion at the nomination page. —Community Tech bot (talk) 04:45, 13 December 2020 (UTC)
thread_title:  A Commons file used on this page or its Wikidata item has been nominated for deletion 

message: I have figured out where the statement about younger animals being more susceptible than older animals to the toxicity of H. perforatum likely came from. https://archive.org/details/journalamer46ameruoft/page/152  Unfortunately it is in a section about Hypericum triquetrifolium then called Hypericum Crispum. While it is not unreasonable to assume that it may also be true for H. perforatum, I have not yet seen a reliable source stating it. 
Of more relevance the same 1914 article it states that at high doses a preparation of H. perforatum "has a very toxic action on the heart" in an experiment on dogs. I'm not entirely sure if that would be a good fact to add to the article or not. It is a very old experiment. MtBotany (talk) 20:23, 5 August 2023 (UTC)
replies: text: Hmm, possibly a very brief mention of the effect on dogs would be appropriate? But yeah I was also dubious of the claim of its effect on younger animals, that was one of the reasons I tagged the section. My vote would be to cut that claim entirely - it isn't particularly important anyways. Fritzmann (message me) 01:48, 6 August 2023 (UTC)
thread_title:  Greater Effects on Young Animals 

message: The redirect ARIADNE7 has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  Plantdrew (talk) 18:44, 7 November 2023 (UTC)
thread_title:  "[[:ARIADNE7]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] 

message: The redirect ARI7 has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  Plantdrew (talk) 18:44, 7 November 2023 (UTC)
thread_title:  "[[:ARI7]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] 

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message: Unders Distribution, there is a discrepancy between the map and the text, which says that the plant is native to Sudan, for example Spacecow2021 (talk) 12:47, 7 December 2023 (UTC)
replies: text: Thanks for the catch, I've updated the map to reflect the distribution listed at POWO, it should be accurate now. Fritzmann (message me) 13:59, 7 December 2023 (UTC)
thread_title:  Native to which countries