Talk:Immunoglobulin E

message: Can someone, not necessarily an expert, please rewrite this run on sentence;
"IgE that can specifically recognise an "allergen" (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis."
Thanks very much 220.101.92.34 (talk).  —Preceding undated comment added 07:50, 11 May 2011 (UTC)
thread_title: Request for rewriting run-on sentence

message: i added a citation needed label to the value that's already in the article. 
i spent a long time googling and haven't found any quotes of "normal" levels (neither with nor without a description of how many standard deviations "normal" actually means!).
If somebody can find this, then we could add one or both of the following refs and also give the value in IU/mL (or kIU/L, which is the same thing). The conversion according to these two references is: 1 IU/mL = 1kIU/L = 2.44 ng/mL. The polish reference gives 2.44, the US one 2.4, so presumably the polish one just goes to higher precision and the US one is a rougher approximation.
* http://www.mp.pl/artykuly/index.php?aid=24925
* http://www.aruplab.com/guides/ug/tests/0050345.jsp
These would put 75 ng/mL = 30.7 kIU/L or 31 kIU/L to keep about the same level of precision.
However, until we get a reference, i don't see much point in adding the kIU/L value.
Boud (talk) 19:32, 7 August 2008 (UTC)
thread_title:  What's the normal adult and/or children's level of IgE? 

message: This hardly seems relevant - when its there with out further introduction? 
"In 1975, Robert N. Hamburger, M.D. published "Peptide Inhibition of the P-K Reaction" based on blocking up to 89% of the IgE receptors on mast cells by the pentapeptide representing amino acids 320 to 324 on the epsilon chain of IgE.[13] Confirming the IgE binding site, in 1979 he published in Immunology "Inhibition of IgE binding to tissue culture cells and leucocytes by pentapeptide" (ref).
I'll remove unless someone objects?  — Preceding unsigned comment added by Radicularia (talk • contribs) 21:25, 4 March 2012 (UTC)
thread_title:  Irrelevant/unexplained? 

message: This article is full of technical terms, explained only by links to other pages, which themselves are full of other technical terms.  This page may (?) be well written for biologists and doctors.  Someone please make it accessible by the average parent who is looking up information for their hyperallergic children.  I do *NOT* mean to "dum it down". Make it as comprehensive as possible. Just leave some of it within reach of non-experts. 69.247.14.176 17:17, 5 February 2015 (UTC)
replies: text: Came here to say exactly the same thing. Take the third sentence of the article as an example: "Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4)."Faff296 (talk) 06:52, 11 September 2017 (UTC)

text: Is spelling dumb as 'dum' an example of dumbing down?Andrew ranfurly (talk) 07:54, 18 May 2018 (UTC)
thread_title: Needs to be comprehensible to the intelligent layman

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thread_title:  External links modified 

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message: I don't see in the article any meaningful explanation of the production of IgEs. There's a graphic and a few allusions to the fact that they are specific to specific antigens, and I'd be curious to have more information about how that comes to be. Unfortunately I don't have the knowledge to add this myself, but if someone else would be able to add it would be appreciated! zplizzi (talk) 16:30, 14 September 2022 (UTC)
thread_title:  Explanation of where / how IgEs are produced?