Talk:Artemisinin

message: The contributions to the biosynthesis of artemsinine are excellent, I find. For my part, my extensions are short and to the point. It is important to create new links to every wikipedia entry. This is done in the spirit of wikipedia. But, I agree, it might appear as too simplistic but yet, usable for those who read it.  —Preceding unsigned comment added by 81.62.47.252 (talk) 01:28, 12 February 2011 (UTC)
thread_title:  Biosynthesis 

message: All those parenthetical numbers are pretty much useless without accompanying structural drawings, but the paragraph was unfortunately written in such a manner as to preclude simply removing them. The section needs a rewrite so that it's no longer dependent on the parentheticals, or it desperately needs a set of structural drawings of the compounds referenced. IMO, this would probably be more useful than the immediately preceding drawing of the biosynthetic (mevalonate) pathway, especially in light of the way the total synthesis is described.64.134.179.130 (talk) 00:19, 29 December 2012 (UTC)
replies: text: PARTLY  I have rewritten the synthesis section, adding secondary citations, and a couple newer primary ones.  It is still in need of a figure, but I am not convinced that the early Schmid design is the best; perhaps two are needed, the first and the best, so at present, it remains without an image (but cum better text, and sans numbers).  Le Prof Leprof 7272 (talk) 09:05, 19 June 2014 (UTC)
thread_title:  Synthesis section 

message: The first two paragraphs of the History were poor when I arrived, and I have tried to improve their readability, and their adherence to WP policies. The two paragraphs were combined, with material from the second ("herb" sentence) placed at an appropriate point in the first paragraph. 
Then, there was a later sentence in the section whose English was unreadable, and whose citations were in a format so as to be unverifiable. That sentence has been corrected, thus:
* "Images of the original scientific papers that record the history of the discovery have been available online since 2006."
and it remains in the article in this edited form.
Next, the citations that appeared with this sentence are unverifiable for various reasons, and are so poorly formatted as to be disruptive to reading. They are therefore moved here to Talk, for the record, and for holding until they can be corrected (REF2) or replaced (REF1 and REF3):
* REF1 http://qinghaosu.blogspot.com/ Qinghaosu Project ]
::Disallowed as a blog posting. Not an acceptable source. Also a bare URL. SOURCE MUST BE REPLACED.
* REF2 (BOOK) Zhang Jianfang (2007) Late Report: Record of Project 523 and the Research and Development of Qinghaosu, Yangcheng Evening News Publisher [Chinese citation: 張劍方 (2007) 遲到的報告五二三項目與青蒿素研發紀實, 羊城晚報出版社]
::May be acceptable, if details can be clarified: Corrections needed are page numbers of information cited, and ISBN or some other unique identifier so book can be sourced. SOURCE MUST BE CORRECTED.
* REF2 http://www.ycwb.com/ycwb/2007-01/05/content_1339932.htm ycwb.com
::Disallowed as a bare URL and as an apparent broken link. Link takes one to an all Chinese page. SOURCE MUST BE REPLACED.
There is a further redacted reference, from the sentence introducing Tu Youyou:
* REF4 http://www.chinavitae.com/biography/Tu_Youyou ChinaVitae: Tu Youyou]
::This is a BLP issue, as this is a curriculum vitae of a living person, based on unspecified Chinese and English web sources, and so it is unclear as to its independence and accuracy. (E.g., sources may include unreliable or self-published information.) Citation also appeared as a Bare URL. SOURCE MUST BE INVESTIGATED FOR PROPRIETY.
Per WP policies, full, standard forms of citations are needed, all the more if the source is rare and/or hard to source. Please do not return these four until the indicated issues are resolved. (Reversion of this edit without change will bring in an administrator.)
Note, REF1 and REF4 are enjoyable and interesting reading, but REF1 is just not a valid source for Wikipedia, and REF4 must be confirmed as reliable, broadly, at WP.  Le Prof Leprof 7272 (talk) 06:33, 19 June 2014 (UTC)
thread_title:  History section opening sentences and overall section tagged for need of citations and some poorly formatted material moved here to Talk 

message: Dear Wikipedia:
Hello;  
Concerning the Wikipedia article on Artemisinin - at https://en.wikipedia.org/wiki/Artemisinin
the important FDA approved Malaria herb/drug does not discuss Artemisinin as an anti cancer drug, why ?
( Adding this information my save or prolong the lives millions of persons affected by cancer. )
Please see Artemisinin as a Cancer Smart Bomb, Part I and 2 :
 at http://www.mwt.net/~drbrewer/canart1.htm and http://www.mwt.net/~drbrewer/canart2.htm and http://www.mwt.net/~drbrewer/FreeCanArtimisUpDate.htm
Quote from Link:
Artemisinin  Cancer Smart Bomb, Part I:
An Idea from Ancient Chinese Medicine
this paper and others can be found at:
http://www.mwt.net/~drbrewer/FreeCancerArts.htm
" The anti-cancer activity of artemisinin against 55 cancer cell lines was tested in the N.C.I.'s (National Cancer Institute) Developmental Therapeutic Program. Artemisinin was found to be most active against leukemia and colon cancer cell lines. Most promising was artemisinin's strong activity against drug resistant leukemia lines. Other cancer cell lines tested that indicated some responsiveness to artemisinin's actions were melanoma, breast, ovarian, prostate, renal and central nervous system cancers such as glioblastoma and neuroblastoma. ("The anti-malarial artesunate is also active against cancer," International Journal of Oncology, 18 {2001} 267-773) " 
http://www.mwt.net/~drbrewer/canart1.htm
(c) 2002 Brewer Science Library, All rights reserved
Excerpted from New Horizons, Summer 2002 issue
article attached 
I researched anti worm drugs / agents as  cancer drugs as I have stage 4 colon cancer.
     Please notice most anti worn parasitic medications also have anti cancer properties. see   your article on the antihelmintic drug Mebendazole at: https://en.wikipedia.org/wiki/Mebendazole  see  https://pdfs.semanticscholar.org/0109/c133ae30079fe21948f85e8c12466b10a903.pdf and the shocking before and after 6 wk photos..( still not a cure ) ( article attached  )
Could Wikipedia please update the Article on Artemisinin an FDA approved treatment for Malaria to reflects its anti cancer properties ? — Preceding unsigned comment added by Dizzo2361 (talk • contribs) 20:01, 17 April 2018 (UTC)
replies: text: Thanks but sources about health need to be OK per WP:MEDRS and mwt.net is not OK.  I will look to see if there are reviews on this drug and cancer... Jytdog (talk) 05:51, 18 April 2018 (UTC)

text: There is a decent recent review; I added some content about that here. Jytdog (talk) 06:21, 18 April 2018 (UTC)
thread_title: Cancer

message: " The malaria parasite enters the red blood cells and sequesters iron. The mechanism of action of artemisinin in "zapping" the malaria parasite is through the affinity of artemisinin to iron. The artemisinin compound contains two oxygen atoms hooked together in what is termed an endoperoxide linkage. In the presence of free iron this linkage breaks down, forming very reactive free radicals that cause rapid and extensive damage and death to the parasite. "
Source Artemisinin a Cancer Smart Bomb, Part I:
An Idea from Ancient Chinese Medicine
http://www.mwt.net/~drbrewer/canart1.htm  — Preceding unsigned comment added by Dizzo2361 (talk • contribs) 01:07, 18 April 2018 (UTC)
replies: text: As above, mwt.net is not OK per MEDRS. Jytdog (talk) 06:21, 18 April 2018 (UTC)
thread_title:  Mechanism of action 2 

message: Relating to artemisinin's advantages over other therapeutics. Having looked at the reference, it seems to be a different subject, with no mention of either malaria, plasmodium or artemisinin. If anyone is working on this page and can get to the bottom if it, would be most appreciated, if not, I'll take a look in due course. 
  TobyBrann 17:59, 26 January 2021 (UTC)
thread_title: Reference 6 is incorrect

message: It seems over hyped to claim in the article that she is the first person in the world to discover this compound. She was probably the first person to name it in the modern sense but not the first person to discover or come across the compound and realise its beneficial effects. Ancient Chinese TCM herbalists have already long been using the same low temperature extraction methods for hundreds of years in treatment of Malaria. She merely rediscovered it after following instructions from an ancient TCM book.https://time.com/4061207/nobel-prize-medicine-ancient-chinese-remedy/ To claim she discovered it, is just like claiming Christopher Colombus had discovered America despite obviously native Americans' ancestors beat him to it. Both claims are absurdly ignorant of actual history. Nvtuil (talk) 20:58, 22 October 2021 (UTC)
thread_title:  Did Tu really discover it? 

message: "Modifications at carbon 10 (C10) position": the numbering of the carbon atoms is not shown anywhere on the page. AndreasJS (talk) 12:14, 8 May 2024 (UTC)
thread_title:  Numbering of carbon positions