Talk:Alpha-1 antitrypsin deficiency

message: Alpha 1-antitrypsin deficiency is not due to amyloid (as stated in this article).
The proteins deposited within liver Cells do not have the characteristics of amyloid.
:Correct. It is, however, accumulated protein. I'll change the article to fit this. PS Get a username and put your knowledge to use!! We'd love to have you! JFW | T@lk 19:14, 24 May 2004 (UTC)
thread_title:  Amyloid 

message: The information in this article (Alpha 1-Antitrypsin Deficiency) contains significant misinformation.  The section towards the end includes the medical recommendation that individuals with this condition take paracetamol (aka acetaminophen or Tylenol) at the least provocation because it will reduce the accumulation of protein within the liver.  There is absolutely no evidence to support this and, in fact, there is growing concern that even recommended doses of acetaminophen or paracetamol can be toxic to the liver.  I have edited this section of the article on several occasions and each time, within hours of the edit a program or person named Smackbot re-edits it back to the original version.  I can only assume this is a misinformed patient or, worse, a manufacturer of paracetamol behind this potentially dangerous misinformation.
Added comment: I am pleased to see that this misleading information has finally been removed from this article.  Thank you.
Robert Sandhaus, MD, PhD
Clinical Director, Alpha-1 Foundation
Professor of Medicine
National Jewish Health  —Preceding unsigned comment added by Ssandhaus (talk • contribs) 18:00, 13 June 2009 (UTC)
thread_title:  Incorrect information in this article 

message: Dr Sandhaus recently published an excellent review article in the New England Journal of Medicine on Alpha 1-Antitrypsin Deficiency that should be incorporated into the article.  Let's be diligent about citing appropriate sources and deleting unreferenced statements.  If certain users continue to re-insert unreferenced claims, perhaps administrative action can be taken.  
Dr Sandhaus's article:
http://content.nejm.org/cgi/content/full/360/26/2749
Wawot1 (talk) 03:00, 9 July 2009 (UTC)
thread_title:  Dr Sandhaus's Excellent New England Journal Review Article 

message: Can we confirm the mechanism of inheritance. OHCM 7 says it is auto rec. Snellios (talk) 21:58, 21 July 2010 (UTC)
replies: text: yep, i  'd it.  it's technically dominant, but doesn't express fully unless both copies are present.  can someone with absolutely cast-iron credentials please call this one?Andrewjlockley (talk) 14:50, 28 December 2010 (UTC)
thread_title:  Inheritance 

message: Our current article generally spells it "Alpha-1 antitrypsin", with just one inconsistent appearance of "Alpha 1-antitrypsin" in the text, and two captions saying "Alpha-1-antitrypsin". Nevertheless, our current title is "Alpha 1-antitrypsin", which none of our references use. Should it be changed to "Alpha-1 antitrypsin"? —173.68.139.31 (talk) 23:31, 26 July 2019 (UTC)
replies: text: Seems it was wrongly redirected some time ago - have put in a page move request. Thanks. Iztwoz (talk) 06:10, 27 July 2019 (UTC)
replies: text: Appreciate the quick fix. Is it possible to do something similar for the misspelled Commons category, too, in the External Links section? —173.68.139.31 (talk) 03:54, 28 July 2019 (UTC)
thread_title:  Misspelled title? Change "Alpha 1-antitrypsin" to "Alpha-1 antitrypsin"? 

message: This has been published a while ago but we make no reference to it: doi:10.15326/jcopdf.3.3.2015.0182 JFW | T@lk 10:28, 9 August 2019 (UTC)
replies: text: The authorship is entirely American, so the recommendations may not reflect practice in other countries. JFW | T@lk 10:28, 9 August 2019 (UTC)
thread_title:  Consensus guidelines 

message: https://www.ersbookshop.com/alpha-1-antitrypsin-deficiency-424-p.asp JFW | T@lk 11:17, 18 September 2019 (UTC)
thread_title:  ERS monograph