Talk:Prodrug

message: Cabamazepine is listed as having no page. I think that there is likely a mispelling. I got to this page from various steps related to Carbamazepine. Based on the content and the other pages I was looking at (which included a drug related to carbamazepine).Especially as it's listed in the section linked to livers, and as I'm taking carbamazepine I need to get regular liver tests. However I'm not a pharmacist so I'm not making the change to the page. Let me know if this ever comes in handy Marcie (talk) 02:33, 16 November 2009 (UTC)
thread_title:  Cabamazepine / Carbamazepine 

message: I simplified the first section.  I used less technical language, and I removed the technical details of specific implementations. I do not believe they are necessary for the introductory/summary section. TheRealJoeWiki (talk) 01:45, 3 September 2012 (UTC)
thread_title:  Tidy-up 

message: I've proposed a merge between Active metabolite because these article appear to be about the same topic, and it would enhance the quality of information on both articles to have it presented in a single place. The articles could be split at a later date if need be. LT910001 (talk) 11:37, 16 October 2013 (UTC)
replies: text: Conceptually, the two terms are related, but I would be careful about saying they are the same topic.  There is a distinction between the two.  The term prodrug is used for a medication that is designed to be metabolized into an active drug.  The prodrug is typically inactive itself - the pharmacological action lies primarily with the metabolite.  With an active metabolite, the parent drug very often is still pharmacologically more important.  A prodrug produces an active metabolite, but an active metabolite doesn't necessary arise from a prodrug.  There is probably a way to handle the two topics in the same article, but it may be easier to keep them separate even if they have some overlapping content.  -- Ed (Edgar181) 11:57, 16 October 2013 (UTC)
thread_title:  Proposed merge 

message: Page needs expanding, with more references.  I suggest adding a discussion of acetylation of salicylic acid as being an inspiration for acetylation of morphine (i.e., heroin, as suggested by others here).  Also recommend referring to The Organic Chemistry of Drug Design and Drug Action by Silverman and discussion of fosphenytoin.  The list of example prodrugs should also be alphabetical.  It's missing a lot of examples (I just added cyclophosphamide).  I'm a new Wiki editor, happy to take the lead.  — Preceding unsigned comment added by PharmaPatentExaminer (talk • contribs) 06:15, 28 January 2014 (UTC)
thread_title:  Suggested points of expansion 

message: This chart lists it as IIA:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978533/table/pharmaceuticals-02-00077-t001/
But this Wikipedia article lists it as IIB. In addition, I've seen a few journal articles that claim the drug is metabolized by red blood cells, which (I believe) would suggest IIB.
Anyone with expertise care to weigh in?  — Preceding unsigned comment added by 98.7.34.119 (talk) 22:22, 22 May 2017 (UTC)
thread_title:  Is lisdexamfetamine type IIA or type IIB? 

message: Тамифлю это пролекарство 89.113.141.133 (talk) 07:49, 11 September 2022 (UTC)
thread_title:  Пролекарство это плохо!?