Talk:DNA polymerase II

message: As part of this class, peer review by three different colleagues was done in order to generate the best article possible. It was suggested by our Chemistry Librarian to add these reviews. 
From NA (student without known username at this time)
Group1 Peer Review
Section1: I think the overall length of is appropriate for wiki page. Some information about pol II does exist in the DNA polymerase page. Group2 does well in expansion of the detail about DNA pol II further. The page include critical information about pol II and are well-categorized. However, you might want to create a link to DNA polymerase site as well as exonuclease and pol III site.   
Section2: Group2 does well to bring up the main concepts about pol II. However, some sections seem to be a bit short and could have been better with some more detail information. Comment on each section will be provided later on. Some sections such as general structure and crystal structure should be combined together unless there is some critically different information to point out. Personally, I’m not entirely sure whether you need to point out the angle and length in crystal structure part. It might be clearer with the figure, but as mention later on about conformational change, I wonder whether this information is important or not. Mechanism part seems a bit too short for me in relative to how important this part should be. The figure included in outline look pretty nice and well-fit to illustrate the explanation.
Section3: Group2 provides well-diverse set of reference including review article and online article. However, I don’t think it’s appropriate to include another wiki page as reference.
Overall comment
Group2 provides important information about pol II in a well-categorized format. The explanation is concise and informative. However, some section could be expanded to make it better while some section could be collapsed. Overall, the work done by group2 provide significant improvement to DNA pol II wiki page. 
Addition comment on each section
1 History
-Do you have reference for rolf knippers?
-You didn’t mention how pol II got the name pol II as plan in the outline. I think you can extend this part in more detail
-You mention about crystallization of pol II by Anderson et al. separately from “myriad of studies during the past few year”. You might want to elaborate on this more if you feel it is a very important step in term of study of pol II.
-Overall, I feel the language is kind of disconnected in this paragraph. This might be automatically fixed when you give some more detail expansion as mention earlier.
2 General structure
2.1 Structure and function
-	In my opinion, I don’t think the last sentence you mention about expression level and comparison to pol III belong to this sub-section.
-	Do you have any reference for the information?
2.2	Crystallography
-	I’m not sure how significant this part is. Can it be combined with general structure? Do you even need to include this section in the first place?
3 Mechanism
-	The information in this part is somewhat lacking. I think you can elaborate more detail here, for example, describing which domain of pol II bind to which location and explain role of each domain of pol II during the mechanism. 
From UMcrc14,
Section 1
The objectives listed in the outline were general, but appropriate for Wikipedia. I did not find much information about DNA polymerase II on other websites besides digging through literature articles—which there was not much there either. After a brief search through SciFinder, I did not even find a review article on this topic. Kudos for picking this topic without much information to go off of! This Wikipedia article will be a good contribution for people who want a quick idea of what DNA pol II is or does because there is not really a site that has the information all in one place. I think the length is appropriate, but some sections should be expanded upon to explain jargon.
Section 2 
Much of the information that I read in the article I felt was repeated throughout at least a couple times (excluding the introduction). I would suggest reading through the entire site as a group and seeing which pieces of information are most pertinent to a section, and if it is pertinent to both, keep it, but if not condense. The only important concept that is missing is the “Health Impacts” section that was listed in your outline, I think this would be something the general audience would be interested in if there is relevant information. There is also a bit of jargon within the text that was not explained, for example, the crystallography section. I would suggest linking “tricky” words to other Wikipedia pages and also not using acronyms unless you have it spelled out somewhere previously on the page. I also noticed quite a few grammatical and some spelling errors, be sure to do a thorough proofread of the site. 
Images
The addition of the crystal structure to the page is a good touch. However, that is the only picture on the page, so far anyways. I really liked the pictures you had in your outline! I think it would be advantageous to add those maybe once you adapt them to be your own. It also might be useful to add pictures explaining the exonuclease activity to perform repair as that seems to be one of DNA pol II’s major functions.
Section 3
There are citations that appear more than once in the references section, so you definitely need to condense that. As I said earlier, I couldn’t find many papers on DNA Pol II, so I think your section has a good mix based on your options to choose from. 
Overall comments
Overall, I think the site provides a better understanding of the role that DNA Pol II has in replication, even though it is still being studied. My major recommendations would be to proofread for small errors (such as capitalizations, italicizations, spelling, etc.), add more images, add links to other pages (either within Wikipedia or to outside cites), and to condense the references section. Also be careful of words that may have an obvious meaning to us as graduate students, but may be foreign to the general reader—definitely use them, but either explain briefly in your text, or link to another page if there is one. 
From jglundgr, 
The goals are clear and appropriate for the first section. There were only a few minor changes I would propose. When E. coli is talked about in the history section the "c" should be lowercase. Replication is misspelled. Maybe a link explaining who Rolf Knippers is would make the sentence a little clearer. In the last sentence the "al" should be lower case. There is a good summary of the history and the general function of DNA Pol II. Had to really try to find something wrong with the first section.  Looks good! 
In the general structure paragraph, the only thing I might change is the wording of the last sentence. The general structure paragraph gives a good overview of the structure of DNA Pol II in a clear and concise way. The first crystallography sentence might be worded more clearly. I would just turn it into two sentences to make the sentence flow better. Also, it isn't clear what the table underneath the crystallography paragraph represents. In the Confirmed Primary Cellular Function section, the first paragraph talks about DNA Pol III being involved with DNA replication, then the next sentence talks about DNA Pol II not being involved with chromosome replication. Perhaps keep it consistent as to avoid possible confusion. The second paragraph needs a comma in the last sentence. In the proposed activity section the first sentence could be worded more clearly. The mechanism is clear  and the cellular function is clear as well. I like how the relationship between DNA Pol II and DNA Pol III and IV is addressed. The regulation paragraph gives good information for how this enzyme is regulated. Overall, not too much to change in this section either. 
As far as the images go, it seems like this group will add some of the pictures later. The pictures in the outline help with the overall understanding of the process of DNA Pol II. Gives a good visual representation of the processes explained in this article. 
The reference seems to be pretty good as well. There is a decent mix of primary literature as well as websites and even other Wikipedia articles. I think the references are diverse and really help explain the information well. 
I really had to go out of my way to find things that I would change for this Wikipedia article. All the changes I would do are very minor. This article is very clear and explains the main points of how DNA Pol II operates. I feel that someone with a small science background could learn easily from this site. It looks like you guys are off to a good start. Overall good job! 
The changes that we have made are reflected in what is now the DNA Pol II page. BiochemEnthusiast (talk) 07:01, 20 February 2015 (UTC)
thread_title: Peer review and responses during the educational assignment in Winter 2015

message: :Category:DNA replication
:Category:EC 2.7.7
:Category:Enzymes
BiochemEnthusiast (talk) 07:10, 20 February 2015 (UTC)
thread_title: References

message: I am working on this article as a part of my educational assignment from January to February, 2015. We plan to expand this stub and add sections such as history, structure and function, mechanisms, and comparisons between the different kinds of polymerases. BiochemEnthusiast (talk) 06:40, 20 February 2015 (UTC)
thread_title: Note to Post

message: Does the ability to reiniate mean, that in contrast to polIII it is possible for polII to start replication without primer?
-- 132.187.246.71 (talk) 08:56, 15 September 2009 (UTC)
thread_title:  Reinitiation 

message: I believe the double-stranded DNA virus family Iridiviridae also has a gene coding for DNA polymerase II.  If my information is correct than the article should indicate that this enzyme appears in both viruses and prokaryotes.  Other than this apparent omission, I found the article quite helpful to an amateur such as myself.Ray Glock-Grueneich (talk) 07:01, 13 January 2014 (UTC)
thread_title: Characterization as a "prokaryotic DNA polymerase"

message: I think the mechanism part is the most important section in the work of poly II, so it is important to add more details such as background for this process.moreover, the article needs to add more images of the mechanism section this will illustrate the process of the DNA Replication. however, the  references that used in the article are good and reliable, also the writer used good writing structure--Albahrani Batool (talk) 21:36, 28 January 2017 (UTC)
thread_title:  about mechanism part