Talk:Kawasaki disease

message: Is anyone able to add a pathology section? The disease is explained and discussed but the underlying mechanism isn't mentioned. 
The Treatment is repeated in the Prognosis. Suggest removing the final line from the prognosis section. Kilbosh 14:24, 4 April 2006 (UTC)
thread_title: Previous discussions without headers

message: If I read this wiki entry correctly, only 2% of children die from this.
I'm wondering if in fact Jett died from this , did the fact that his parents are Scientologists (don't adhere to some modern medical treatments) have anything to do with his death.
In other words, was he getting proper treatment?  —Preceding unsigned comment added by 65.184.76.241 (talk) 21:53, 2 January 2009 (UTC)
replies: text: The page may need protection, or a blurb about the boy's death to be left up for, say, a week?sinneed (talk)
Jett Travolta son of John Travolta is hardly "famous", and is probably not even notable. It is certainly not clear that he died from Kawasaki Syndrome. Perhaps this section should be renamed, or deleted? AussieBoy (talk) 06:17, 4 January 2009 (UTC)
thread_title:  [[John Travolta]]'s son had this disease and just died? 

message: Now that Kawasaki disease is in the news, this page will get a lot of hits. It attracts vandalism, but it's also a teachable moment to educate people about Kawasaki disease. 
It's a good educational opportunity, because autoimmune diseases, and specifically vasculitis, is a large class of important diseases with high incidence. Nbauman (talk) 06:24, 6 January 2009 (UTC)
thread_title: Teachable moment

message: A recent international study has identified new genes that appear to affect susceptibility to Kawasaki disease. The study found that genes involved in cardiovascular function and inflammation may be particularly important and some seem to function together. 
Reference: The article is in PLoS Genetics, an open-access journal, and is freely available online at http://www.plosgenetics.org/doi/pgen.1000319. Citation: Burgner D, Davila S, Breunis WB, Ng SB, Li Y, et al. (2009) A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease. PLoS Genet 5(1): e1000319. doi:10.1371/journal.pgen.1000319   PMID: 19132087 Plosgenetics (talk) 16:18, 13 January 2009 (UTC)
thread_title:  Update for 'Causes' section 

message: Whoever is working on this article - check refs 3 and 4 in the Presentation section - I removed some vandalism, but the refs themselves appeared to be valid sources for Kawasaki disease.  I'm just not sure where you want to use them. — Ched ~  (yes?)/© 06:58, 15 March 2009 (UTC)
thread_title:  refs 3 and 4 

message: I categorized this under Category:Virus-related cutaneous conditions under the rational from section Pathogenesis chapter 80:1232-4 from Dermatology Second edition from Bolognia, Jean L. .  Calmer Waters 20:25, 24 December 2009 (UTC)
replies: text: Sounds great! ---kilbad (talk) 20:28, 24 December 2009 (UTC)
replies: text: However, its already under Vascular cutaneous conditions Calmer Waters 20:37, 24 December 2009 (UTC)
replies: text: You can do both if you want.  Your call... ---kilbad (talk) 20:38, 24 December 2009 (UTC)
replies: text: Uggh. That one was killing me. Spent the last hour trying to pin it down only to find out it was already in one. Two it is. Thanks Calmer Waters 20:44, 24 December 2009 (UTC)
thread_title:   Category:Virus-related cutaneous conditions 

message: On the grid of pictures picture G doesn't look like any way of giving BCG that I've seen (could be a Heaf test I suppose). 3x3 grids of needle pricks look like some form of a skin prick (allergy) test to me. Looks like it came from a journal but doesn't necesarily mean the right caption or correct picture made it into the article. Going to be awkward to photoshop it out though. Arfgab (talk) 14:07, 13 April 2010 (UTC)
replies: text: You are right, I took the picture and the caption from the same article that I am citing. I think that this mistake was published in the paper too, if it is a mistake in the first place. But as you said, I ve never seen a smiler BCG vaccination, so what do you think should be done here?? MaenK.A.Talk 15:08, 13 April 2010 (UTC)
replies: text: I guess the only thing would be to e-mail the author for clarification. It is Korean and I've never worked there so they may do things differently. Arfgab (talk) 19:59, 13 April 2010 (UTC)
replies: text: Not sure why there are 2 grids on this picture but take a look at the picture around Bacillus_Calmette-Guérin#Method of administration and see if you think that looks familiar. (Apologies to Dr Kim) Arfgab (talk) 20:03, 13 April 2010 (UTC)
thread_title:  Picture query (picture G) 

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thread_title: File:KAWASAKI1.jpg Nominated for Deletion

message: This line is misleading for the prognosis of kawasaki disease. Though this disease is a type of coronary vasculitis, coronary vasculitis isn't exclusively kawasaki disease. If it is meant to be representative of kawasaki disease then the 2% quoted is most likely a SMR, or standard mortality ratio, that quantifies an increase in mortality relative to the general population. For instance, in "Sudden Death in an Infant Revealing Atypical Kawasaki Disease" the mortality rate caused by KD is 2.8% higher than the general population. Diana MC, Villa G, Gattorno M, Ottonello G, Costabel S, Savioli C, DiPietro P. 2006. Sudden Death in an Infant Revealing Atypical Kawasaki Disease. Ped Emerg Care. 22(1):35-37. The Merck Manual quotes 0.17% mortality rate with adequate therapy in the United States.
  — Preceding unsigned comment added by Kimqcat (talk • contribs) 04:09, 1 July 2013 (UTC)
thread_title:  Overall, about 2% of patients die from complications of coronary vasculitis 

message: The article as it is now states that we should call it Kawasaki Syndrome, in the causes section. The reasons given for this are that the cause is not known. However, immediately after this statement, the article resumes calling it Kawasaki Disease. Is this an issue, and if so, is there a way to correct it?  — Preceding unsigned comment added by 174.20.189.191 (talk) 15:02, 18 October 2013 (UTC)
thread_title:  Causes 

message: The first couple of sentences here could be reworded to be clearer. Also the wiki link from "remittent" goes to the article "Fever". I made an attempt at fixing the latter and then realised I'd misinterpreted the sentence. Will try to remember to revisit but writing here in case I don't. Dichohecho (talk) 12:15, 15 September 2016 (UTC)
thread_title:  Structure in "Signs & Symptoms" 

message: doi:10.1161/CIR.0000000000000484 JFW | T@lk 08:28, 25 April 2017 (UTC)
thread_title:  Scientific statement 

message: The following Wikimedia Commons file used on this page or its Wikidata item has been nominated for deletion:
* 
Participate in the deletion discussion at the . —Community Tech bot (talk) 13:22, 3 May 2020 (UTC)
thread_title:  A Commons file used on this page or its Wikidata item has been nominated for deletion 

message: This is the definition provided at the start of the main text of the current AHA guidelines:  Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause that predominantly affects children <5 years of age. I believe we need to go with something along those lines at the start of the lead that highlight the paediatric context – especially for the benefit of casual readers, including ones coming rapidly to this page following current newspaper reports regarding unusual COVID manifestations in some infants. 86.134.212.26 (talk) 14:09, 8 May 2020 (UTC)
replies: text: Okay simplified a bit to "is a disease of unknown cause that results in a fever and mainly affects children under 5 years of age" thoughts? Doc James (talk · contribs · email) 02:23, 9 May 2020 (UTC)
replies: text:  Ok, though I believe the clear-cut 'vasculitis' definition (per PubMed Health ) also needs to be close to the top, as it was before (rather than trailing speculation regarding the mechanism). Will switch that one back . 86.134.212.26 (talk) 12:15, 9 May 2020 (UTC)
replies: text: Sure, moved some of the less common symptoms out of the lead. Doc James (talk · contribs · email) 08:16, 10 May 2020 (UTC)
replies: text:  Agree, and looking good, imo :-) 86.134.212.26 (talk) 09:54, 10 May 2020 (UTC)
thread_title:  Definition 

message: At present we have a summary at the foot of == History == of the ongoing open questions regarding Kawasaki-like presentations. Imo, that's appropriate, whereas (per WP:RECENT, whereas news-style (local/global) updates would not be on this page about a particular clinical entity (example).  Clearly, per WP:MEDRS, it would be premature to insert speculative/primary-sourced content in clinical sections (e.g. == Causes ==). A little like User:KalanK10 (I think) however, I have been wondering whether some brief mention of the issue should be made at the foot of the lead, as that might be what general readers would expect. Personally, I feel something of the sort  may be appropriate.  86.134.212.26 (talk) 10:28, 10 May 2020 (UTC)
thread_title:  COVID-19 

message: We mention PMIS both in the infobox under differential and in the second paragraph. We do not also need a banner at the top of the article. 
Doc James (talk · contribs · email) 05:55, 14 May 2020 (UTC)
replies: text: Didn't see it in the infobox, apologies. Was hoping the hat note would spur editors to update the PIMS page instead of this one and a few others. If you get a chance could you give the multisystem inflammatory syndrome disambiguation a look over to see if it is clear enough? Best, Classicwiki (talk) If you reply here, please ping me. 16:33, 14 May 2020 (UTC)
thread_title: Moving here

message: @User:Doricke: The content added here is sourced to a (possibly still not peer-reviewed) hypothesis-type paper which does not comply with WP:MEDRS:
A novel hypothesis that Kawasaki disease is caused by dysregulated activation of mast cells by Fc receptor-bound pathogen antibodies accounts for much of the pathology of this disease.  Histamine release from mast cells induces contraction of pericyte or effector cells on cardiac capillaries impeding blood flow.  Back pressure from capilaries occulsions induces coronary aneurysms in some patients.  Other Kawasaki disease symptoms can be linked to increased histamine levels. 
 
86.186.155.159 (talk) 08:44, 12 June 2020 (UTC)
thread_title:  moved content 

message: From diff (apparently following on from earlier addition of analagous content by  Doricke, a SPA whose user name virtually coincides with that of the first author of this hypothesis-type paper):
The hypothesis has been put forward that Kawasaki Disease is caused by antibody activation of mast cells.
 86.186.155.159 (talk) 08:38, 24 July 2020 (UTC)
thread_title:  moved content 

message: (some *selected* recent potential medrs etc, as of June 2020; not all actually cited):
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86.186.155.159 (talk) 12:24, 15 June 2020 (UTC)
thread_title:  Some current MEDRS 

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86.186.155.159 (talk) 12:24, 15 June 2020 (UTC)
thread_title:  Reviews 

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86.186.155.159 (talk) 12:24, 15 June 2020 (UTC)
thread_title:  Recent SCIRS for History