Talk:Tetrahydrobiopterin

message: I don't have time to learn how to edit this page right now.
But I noticed the chemical structure of tetrahydrobiopterin is wrong.  There are 5 things bonded to the carbon.  The correct structure is actually back in the history of this article a few edits ago.... with the N in the ring that's double bonded to the carbonele .... should actually be an NH - single bonded to the carbonele (because it's impossible to have it according to the way the curren png picture shows).
: Fixed... it was my careless mistake. Thanks for the notice. solon 11:44, 17 June 2006 (UTC)
thread_title:  Structural formula 

message: I have a genetic disorder on GCH1 which causes a deficiency in BH4 production - I am therefore unfortunately more familiar with BH4 than I'd like to be.  As I am not a biochemist, I merely added "citation needed" at the end of the first sentence instead of fixing it - BH4 is not involved in the production of those neurotransmitters, however.  Instead of changing current content, I opted for adding additional content (added "other clinical issues").  
This entry (and the one about Tetrahydrobiopterin_Deficiency) unfortunately reads like an advertisement for BioMarin and what the FDA has approved Kuvan to be prescribed for; BH4 has many roles that are *exceptionally* more important than treating toxic levels of L-Phenylalanine.  That role isn't really a "role" - it's a byproduct of proper biosynthesis of L-Tyrosine which is directly, not indirectly, needed.   The vast majority of clinical issues resultant from BH4 deficiency happen long before toxic levels of L-Phenylalanine in the blood, which itself can be alternately treated (as it was, until 2007) by simply lowering the intake of that amino acid - but would still leave a patient with dangerously low levels of L-Dopa and would leave all the other conditions (which are all indirectly caused by the low BH4 levels) still completely untreated.  I can avoid L-Phenylalanine in my diet (I don't need to, as my levels aren't high enough to be toxic), but that won't make my dystonia go away.  Note that 99% of PKU is not caused by BH4 deficiency, either (Biomarin's own research); one could have PKU and not have any issues with Dopamine levels.
This isn't meant as a harsh to Kuvan/Biomarin; I'd take it if my physician wasn't hesitant to prescribe it in concert with Sinemet.  Suggesting BH4 is primarily vital for reduction of L-Phenylalanine levels is very misleading however, in my (admittedly not classically trained) opinion.  Taking Kuvan, the drug, is approved primarily for PKU treatment.  The two things are not analogous - the FDA doesn't define the deep medical Truths we hope humanity one day discovers.Brianlamere (talk)
There is paper showing that BH4 is a cofactor for NO synthases "The Three Nitric-oxide Synthases Differ in Their Kinetics of Tetrahydrobiopterin Radical Formation, Heme-Dioxy Reduction, and Arginine Hydroxylation*" by Chin-Chuan Wei et al, published in 2005.  I've seen papers citing the role as cofactors for the enzymes necessary for making neurotransmitter precursors, but I don't have a copy of it on my computer.  I'll post the titles / authors here if I can find them.  —Preceding unsigned comment added by 65.47.29.74 (talk) 21:19, 2 May 2011 (UTC)
thread_title:  Role of BH4 very incomplete, and somewhat inaccurate, as described 

message: :The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion. 
The result of the move request was: no consensus. (closed by non-admin page mover) Vpab15 (talk) 16:50, 18 July 2022 (UTC)
replies: text: Tetrahydrobiopterin →  – Use the INN for the page name per WP:MEDMOS, WP:PHARMMOS Whywhenwhohow (talk) 20:14, 24 June 2022 (UTC)
thread_title:  Requested move 24 June 2022