Talk:Superoxide dismutase

message: I am removing that part about delivery systems.  Reeks of advertisement and unproven claims.  —Preceding unsigned comment added by 24.198.36.244 (talk) 05:45, 6 November 2008 (UTC)
thread_title:  Delivery systems

message: Removed because it's too vague:
:the existence of a motor neuron disease in individuals who have point mutations in SOD and by the finding that the absence of SOD may lead to a form of anemia.
--Quarterduck 02:54, 21 Dec 2004 (UTC)
thread_title:  Vague statement 

message: This statement is unreferenced:
"Mutations in SOD1 can cause familial ALS, by a mechanism that is presently not understood, but not due to loss of enzymatic activity or a decrease in the conformational stability of the SOD1 protein."  Anyone wish to clarify to what this is referring?173.8.220.209 (talk) 23:49, 23 February 2010 (UTC)
thread_title:  SOD mutations in disease 

message: (Using Firefox to view page)
The image above the text "Structure of the active site of human superoxide dismutase 2" is covering part of the page's main text. The Image should be moved. This may be a problem specific to Firefox.
Cs1kh 17:13, 23 July 2007 (UTC)
thread_title:  Page requires reorganising 

message: With all due respect, I placed Pfam boxes to section "Types" where they belong. And do we really need protein boxes here when we have separate articles about individual proteins, clearly linked from this article. That's a content fork, classic. Saying that, I am not going to revert anything. But it does include an excessive number of boxes. Something must be removed.Biophys (talk) 22:55, 18 October 2010 (UTC)
replies: text: OK, I now see that you did place the Pfam boxes in the "Types" section, but when stacked vertically they do extend into other sections. Also to avoid bunching of section editing links, the infoboxes should ideally be placed next to each other separated by fix bunching templates.  Even taking out the  templates, this is awkward because of the number of remaining infoboxes and graphics.  A cleaner solution is to pivot the infoboxes so that they are displayed horizontally. This ensures that no mater what the window width or font size that is displayed, the infoboxes will all ways displayed next to the corresponding text.  Furthermore, placing  that are an abbreviated version of the  is not a content fork but rather a summary of what is contained in the isozyme specific articles.  Finally, considering the length of the text in the article, I do not think there is an excessive number of infoboxes. Boghog (talk) 15:34, 28 November 2010 (UTC)
thread_title: Formatting and boxes

message: Cindy Crawford's widely advertised "meaningful beauty" skin regimine claims'
that SOD via a south of France melon extract does benefit one to remain youthful looking and that this is all proven , e.g. now with her use for 15 years remaining looking 30 vs 45 age.  Can you add this info if accurate ?
ref http://www.meaningfulbeauty.com/ /s flowa o scotland le jeune jr, camp le 69.121.221.97 (talk) 14:13, 28 November 2010 (UTC)
thread_title: Meaningful

message: I fail to see how an unproven commercial statement for a cosmetic product would enhance the article.  Therefore, I would strongly oppose such a statement.  RGK (talk) 01:34, 27 March 2014 (UTC)
thread_title:  Meaningless 

message: Run thru with several text and syntax edits,  plus well-cited new material.  Made a separate section on pharmacological uses of SOD and SOD-mimetics.  There is also a whole separate area of SOD-mimetic agents as drugs that should be considered in more detail.   BTW,  years ago,  I put in the stuff about pharmacological uses of SOD.  But over the years the usual suspects seem to have deleted it.  Arrrg... Bigbuck (talk) 19:54, 16 February 2012 (UTC)
thread_title:  Varius text/syntax edits 

message: The second sentence of the section: Pharmacological activity, read:
"For example, SOD is highly effective in treatment of colonic inflammation in experimental colitis."
The syntax needed editing and as I know of now such thing as "experimental colitis" and as there is no reference to it on the colitis page associated with the phrase I have edited it to:
"For example, SOD is a highly effective experimental treatment of colonic inflammation in colitis."
and added the request thereon for a citation.
fwiw I know what you mean about "the usual suspects", those self-appointed traffic wardens of the information superhighway.
----LookingGlass (talk) 04:15, 23 April 2013 (UTC)
thread_title:  Experimental colitis ? 

message: SOD is a critical enzyme to all aerobic organisms, and free radical biology and medicine, while arguably the most important subject matter in biology, is very broad, too broad to support specific uses of SOD in experimental medicine.  An article on colitis might be more appropriate, although I would reserve that statement to a specific example after reviewing it.  — Preceding unsigned comment added by Robert Kavanaugh (talk • contribs) 01:41, 27 March 2014 (UTC)
thread_title:  Reasonable Limitation to Subject Matter 

message: The following opening statement is taken from the abstract to the paper "Antifibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts" by Vozenin-Brotons, Sivan V, Gault N, Renard C, Geffrotin C, Delanian S, Lefaix JL, Martin M: 
 Skin fibrosis is characterized by the proliferation and accumulation of activated
 fibroblasts called myofibroblasts
It appear to indicate that the statement in this article here that: 
"Superoxide dismutase is known to reverse fibrosis, perhaps through reversion of myofibroblasts back to fibroblasts"
and claimed to sourced from the magazine Free Radical Biology & Medicine, is incorrect by definition. I have therefore requested that the citation be improved.
Elsewhere on wiki, where it is stated that: 
"fibrablasts and fibrocytes are two states of the same cells, the former being the activated state, the latter the less active state... Currently, there is a tendency to call both forms fibroblasts."
I assume that in the first paper the term: "activated fibroplasts" is used merely to emphasise the fact that it is actually fibroplasts that define fibrosis rather than fibrocytes, however the quote in the article here still seems wrong, again as stated elsewhere on wiki, as: "myofibroblasts are defined as "between a fibroblast and a smooth muscle cell in differentiation."   It would seem to follow from definition therefore that changing from myofibroblast back to a fibroplast would be to create fibrosis rather than to reverse it.  Can anyone clarify? 
----LookingGlass (talk) 08:30, 23 April 2013 (UTC)
thread_title:  Improved References Needed 

message: I wish to propose a new section to consolidate and summarize current peer review journal articles on the use of phytochemicals, specifically polyphenols,(or even drug candidates) but not limited to those compounds, that are documented agents used for the induction and upregulation of mnSOD, SOD1, and SOD3.  Mostly, I've been following the work Brock University, (Dr. Jeffrey A. Stuart, Ellen Robb et.al) which documents SOD2 induction via ER-beta using genistein, daidzein, trans-resveratrol, and other phytoestrogens; and I'm interested in collaborating with a group to review the literature to clarify the role of induction of SOD via NRF2/Keap1; as well as clarify and establish consensus regardings studies indicating SOD may be upregulated via the Sirtuins.  However, the role of dietary polyphenols and other dietary compounds shown to induce and upregulate SOD may misplaced in an article which tackles plenty in just describing the enzymes themselves.  Thus, first, I'd be interested in opinions regarding my proposal to expand this particular article to include SOD induction.  RGK (talk) 01:25, 27 March 2014 (UTC)
replies: text: My off-the-cuff reaction is that this sounds quite worthwhile, but might work best as a separate article, referred to and with a couple of sentences to explain it, in the main SOD article. I can't easily help with it, tho, since it's not the end I know much about, and I seem to have fallen behind on everything at present. Dcrjsr (talk) 01:45, 27 March 2014 (UTC)
thread_title:  SOD Induction 

message: Not used or explained in article. 86.159.197.174 (talk) 15:58, 22 August 2014 (UTC)
replies: text: Now added to erythrocuprein, as one of the previous names for SOD when its function was unknown. Dcrjsr (talk) 02:12, 6 October 2014 (UTC)
thread_title:  Why does "cytocuprein" redirect here? 

message: I was trying to learn more about manganese in superoxide dismutase and I read this, "Manganese – Chicken liver (and nearly all other) mitochondria," and it is not clear if the manganese SD is in the mitochondria of nearly all livers or just all mitochondria, so it needs to be changed to either, "chicken liver and nearly all other liver mitochondria" or just "nearly all mitochondria," or what was actually meant by the statement, because it isn't clear at all.  Every time I make an edit some edit god comes along and reverses it, so I am not so sure it is worth my time to figure out how to correct it, but it does need to be corrected.  — Preceding unsigned comment added by Dwot (talk • contribs) 13:26, 20 February 2016 (UTC)
thread_title:  grammar is not explicit and is confusing 

message: Is SOD = Superoxide Dismutase significantly more bioavailable for mice, compared to humans?
Could the following research apply to human Maotai liquor consumption?
https://www.hindawi.com/journals/omcl/2022/5397733/
Title: Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction
Abstract: A portion of mice were treated with Maotai liquor (MTL, in short). 
4. Discussion: Published data show that MTL can counterpart oxidative stress in liver cells by increasing SOD production and inhibiting ROS and MDA [6]. MTL also contains SOD (6667 U/100 ml) and manganese (0.022 mg/100 ml); those are important for alleviating the oxidative stress injury
--91.159.188.74 (talk) 22:11, 19 February 2022 (UTC)
thread_title:  Is mice SOD research applicable to humans?