Talk:Low-threshold spikes

message: This page is being updated as part of Dr. Burdo's BI481 Introduction to Neuroscience course. It is in the process of being reviewed and will be updated throughout the semester. Financ (talk) 20:57, 5 November 2012 (UTC)
thread_title: Untitled

message: For the improvement of this article, I think a short introductory paragraph of what low-threshold spikes are should be added. The article seems to just dive in to T-type channels without addressing the low threshold spikes: “The T-type calcium channel is found in neurons throughout the brain. These channels produce particularly large currents in thalamic, septal, and sesnory neurons. Due to their activation near the resting membrane potential, as well as their fast recovery from inactivation, they are able to generate low-threshold spikes.” Also, in this section, sesnory should be changed to sensory.  In the history section, I feel you could go more in-depth about the experiment that discovered low-threshold calcium current rather than just briefly mentioning it. 
We added an introductory paragraph so the section on T-type Ca2+ channels should fit better now. Typo was fixed. The history section was incorporated elsewhere into the article - there is not much more to say about the history, as the details pertaining to LTS from the first experiment are built into the entire article.Financ (talk) 19:47, 2 December 2012 (UTC)
thread_title: Peer Review

message: I thought that this article was very informative and personally very interesting.  To improve the article, I think you should include the introduction paragraph in the beginning that summarizes some of the main ideas of low-threshold spikes.  I also noticed that you have some typos as well as few grammar mistakes.  So it would be nice if you should proofread once more.  And there are some paragraphs that do not have citation at the end. (history section for example)  You should go through your article to make sure that they are all cited. 
We consolidated the "history" section with other background info that was in the article and created an introductory paragraph as well as proofreading and adding citations. Thanks!  CorinneMarieClifford (talk) 17:51, 2 December 2012 (UTC)
thread_title: Peer Review

message: Nice job so far. I think you should add an introduction to your article instead of jumping right in discussing T-type calcium channels. As for organization, I think your article may flow better if you move the “T-type calcium channel” section and incorporate it further down in your article. At the beginning of the “Physiology”, “LTS Kinetics”, and “T-type calcium channels” sections, you define LTS. I think you should consolidate your definitions of LTS and place it at the beginning of the article, in the introduction. I have a question about some of the material in the “Physiology” section. Here, you state that spike bursts are caused by hyperpolarization and subsequent calcium channel deactivation, but later on in “LTS Kinetics” it says: “LTS is a large depolarization due to an increase in Ca2+ conductance…” There seems to be a contradiction regarding calcium channel activation versus deactivation. I also suggest that you elaborate on the “History” section of the article. Also, make sure you proofread your article: if you are going to abbreviate low threshold spikes to LTS, be sure to relate the two as “low threshold spikes (LTS)” early on in your article. -Reedich (talk) 22:32, 29 November 2012 (UTC)
thread_title: Review