Talk:Isoniazid

message: The article has two explanations for hepatotoxicity:
# Hepatotoxicity of INH is by nitrogen group in its chemical structure, as it is metabolized in the liver and gets converted to an ammonium molecule, which causes hepatitis.
and
# Isoniazid is metabolized by the liver mainly by acetylation and dehydrazination. The N-acetylhydrazine metabolite is believed to be responsible for the hepatotoxic effects seen in patients treated with isoniazid.
Both phrases, by the way they are written, give the notion that their mechanism is the only one responsible for hepatotoxicity, they do not allude to other possible mechanisms.
So which one is true? Ericobnn (talk) 20:37, 21 June 2013 (UTC)
thread_title:  Conflicting explanations for hepatotoxicity 

message: 12:04, 30 May 2007 (UTC)
thread_title:  Why is Isoniazid given to people who have arthritis not TB?  What are the risks for this? 

message: The focus on contraceptives in the paragraph discussing Isoniazid's inhibition of P450 enzymes is odd. It's not incorrect, but a large host of drugs will exhibit decreased metabolism as a result of Isoniazid use (Warfarin comes to mind). Similarly, Rifampicin is a universal enhancer of the P450 system, so only mentioning its effects on oral contraceptives is odd given that the effects of the vast majority of drugs that are metabolized in the liver will be affected (perhaps Rifampicin doesn't even need to be mentioned on this page though they are often given together). Perhaps this section can be rewritten to reflect that the effects of many common drugs will be enhanced by Isoniazid (and reduced by Rifampicin) rather than mentioning only contraceptive drugs?  — Preceding unsigned comment added by 24.254.185.40 (talk) 17:20, 23 March 2014 (UTC)
thread_title:  P450 side effects 

message: "The drug was first tested at Many Farms, a Navajo community, ..."
This seems unlikely to be true.  A detailed history of the development the early ant-tuberculosis drugs is given in "Tuberculosis: The Greatest Story Never Told", Frank Ryan, Swift, 1992.  On p350 it is asserted that clinical testing of isoniazid on humans was conducted by Herbert Fox at the Sea View Hospital, New York in May 1951.  On p361, an account of the Navajo trials is dated as the first half of 1952 - i.e. between six months and a year later than Fox's trials. g4oep.  — Preceding unsigned comment added by 77.96.60.31 (talk) 08:22, 2 November 2014 (UTC)
thread_title:  First Human Trials 

message: Article incorrectly mentions that isoniazid is a p450 inducer  — Preceding unsigned comment added by 64.134.222.93 (talk) 00:52, 28 December 2014 (UTC)
thread_title:  incorrect P450 effect 

message: Our goal: improve use of lay language, add citations to unreferenced sections and give a more comprehensive overview of isoniazid use 
Focus: We improved the lead section by expanding the information on use and MOA, organized the side effect section with a new drug-drug interaction subsection, and added a new section on specific populations (pregnancy, children, elderly). 
Gracekim9 (talk) 19:14, 5 November 2015 (UTC)
thread_title:   GraceKim9 edits: 

message: Great job. The article has a neutral position and has good sources. The addition of a special populations section was a good addition. Here are a few areas of improvement:
- The lead section has quite a bit of technical language, especially when talking about side effects
- The side effects section should mention that pyridoxine is vitamin b6 (or in special pop. section when it's first mentioned)
- The special populations section wording could be changed, to "it is recommended" or "can take" rather than "pregnant women should take"
- Not sure if you worked on it, but the MOA section is lacking any citations. Should include a source!
Overall, good job :)  — Preceding unsigned comment added by YykimSOP 8 (talk • contribs) 08:53, 9 November 2015 (UTC)
thread_title:  Peer Review