Talk:Fexofenadine

message: This article needs to be expanded Jdoelder (talk) 20:19, 21 May 2009 (UTC)
thread_title: Expansion

message: Is there any indication that this will go over-the-counter in the U.S.A like Claritin and Zyrtec? I hope it will be OTC sooon as it seems to be the best and safest of the three.   —Preceding unsigned comment added by 4.224.3.34 (talk) 01:15, 6 July 2008 (UTC)
thread_title: OTC in U.S.A.?

message: does anyone know which enantiomer of the molecule works the best? Or is it exactly equal? Sikkema (talk) 14:27, 4 June 2008 (UTC)
replies: text: works for me. Maybe you mistyped it and didn't notice? Graham 11:42, 6 April 2006 (UTC)

text: The statement clearly concerns terfenadine, an older drug which was replaced by fexofenadine. Further details and links can be found in the terfenadine article. — Jan (158.195.162.8 (talk) 20:33, 29 May 2008 (UTC)
thread_title:  question 

message: Per this email thread?  Thanks, GChriss <always listening><c> 05:22, 8 February 2008 (UTC)
thread_title:  OK to remove specific dosing instructions? 

message: According to the offical allegra website, their dosing instructions state: 
It is recommended that the administration of ALLEGRA-D 12 HOUR with food should be avoided.
Link: http://products.sanofi-aventis.us/allegra_D12/allegra_d12.html#dosage
I would appreciate it if anyone could weigh in on this.  Thanks! monkeynoze (talk) 22:33, 26 May 2008 (UTC)
replies: text:  The intake of food could possibly diminish the effects of the drug, simply because eating adds a lot of material to the intestines, so that the adsorption into the body is not that quick. No harmful interactions are expected. Sikkema (talk) 14:30, 4 June 2008 (UTC)
thread_title:  Dosing Instructions? 

message: SVG file contained has the organolithium compound incorrectly drawn with a cyanide group.  I've quickly switched it over with the GIF version which is correct, but someone with more time on their hands might want to rework the SVG file.  —Preceding unsigned comment added by 86.136.142.224 (talk) 14:14, 16 May 2010 (UTC)
thread_title: SVG file

message: can tb. fexofenadine used during pregnancy?  — Preceding unsigned comment added by 118.102.186.1 (talk) 07:26, 16 July 2011 (UTC)
thread_title:  can tb. fexofenadine used during pregnancy? 

message: The following 3 copy and pastes from the article seem to provide conflicting conclusions, about the way the drug works and also whether it can or cannot cause drowsiness. The intro section says it does not readily cross the blood-brain barrier, so it causes less drowsiness.  The Side Effects section says that drowsiness and sleepiness are two of the most common side effects.  And the Mechanism of Action section says that it cannot cross the blood-brain barrier and therefore does not cause drowsiness.
If the last statement is accurate, that would seem to make an awfully strong selling point for using this drug for allergy relief.  But the other two sections cast doubt on whether that is true or not.  I don't know if this is just a difference of opinion from different article sources, or whether the science is inconclusive.  But this would seem to be a great thing to get clarification/corrections on, for people like me who don't know what to believe after reading this.
Here are the 3 copy and pastes from the article sections:
(from introduction)
Fexofenadine, like other second- and third-generation antihistamines, does not readily cross the blood–brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Side effects
The most common side effects are headache, nausea, dizziness, drowsiness and sleepiness;
Mechanism of action
Fexofenadine cannot cross the blood–brain barrier and therefore does not cause drowsiness.
Vol-Addict  — Preceding unsigned comment added by Vol-Addict (talk • contribs) 08:04, 27 May 2012 (UTC)
thread_title:  Inconsistency Between Intro & Side Effects & Mechanism Of Actions Sections 

message: Persons not well versed in organic synthesis ought not edit subsections of Wikipedia articles dealing with synthesis. The relevant prose found in this article (as of 5/27/2012) is poorly constructed, even atrocious.
FOR SHAME!  — Preceding unsigned comment added by 71.202.140.109 (talk) 08:54, 27 May 2012 (UTC)
thread_title:  Synthesis 

message: Please check this statement ". It works by being an antagonist to the H1 receptor.[3]"  To the best of my knowledge, its mechanism is "reverse agonist"  That is, the receptor exists in multiple states and antihistamines activate the "off" state.
152.133.7.192 (talk) 22:36, 22 November 2013 (UTC)
thread_title:  Mechanism of action: antihistamines 

message: This particular phrase "the half-life of fexofenadine is shorter than cetirizine," doesn't match (there isn't internal consistancy) with the information on Pharmokinetics on these two drugs.
If you look at the Pharmokinetics of Fexofenadine in the sidebar you see "Biological half-life 	14.4 hours"
- https://en.wikipedia.org/wiki/Fexofenadine
If you look at the Pharmokinetics of Cetizirine in the sidebar you see "Biological half-life 	8.3 Hours"
- https://en.wikipedia.org/wiki/Cetirizine
How therefore does fexofenadine have a half life shorter than cetirizine? It seems to be approximately double.  — Preceding unsigned comment added by 146.199.174.57 (talk) 08:38, 11 May 2016 (UTC)
thread_title:  Half Life discrepancy 

message: Please review this article while it's displayed as second-generation antihistamine but here: https://en.wikipedia.org/wiki/H1_antagonist#Second-generation_and_third-generation_.28selective.2C_non-sedating.29 displayed as third-generation antihistamine.
If you know the true than please edit the article.
Thank you  — Preceding unsigned comment added by 188.163.73.118 (talk) 00:48, 20 December 2016 (UTC)
thread_title:  Second-generation antihistamine OR third-generation antihistamine 

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thread_title:  External links modified