Talk:Serotonin–norepinephrine reuptake inhibitor

message: I have had (an admittedly cursory) look at the sources, and nowhere do I see any mention that SNRIs in general have milder sexual side effects than SSRIs. As for elevated norepinephrine levels causing anxiety, well perhaps but so could elevated serotonin levels. The implication that this is an expected, routine side effect of the NRI effect along with elevated pulse BP etc is at odds with the fact that SNRIs and indeed NRIs are approved for panic disorder and a wide range of other anxiety disorders 2A00:23C5:628C:A000:6D27:589E:A951:D3B4 (talk) 20:39, 7 July 2017 (UTC)
thread_title:  Side effects 

message: I have read, although not from any reliable source, that the pain medication Tramadol (Ultram, Ultracet) is also a slight SNRI. If anyone knows more about this medicine it might be useful to add this drug to this page. I've heard of people taking Tramadol with other SSRIs and SNRIs and getting serotonin syndrome, because some doctors don't even know about Tramadol's anti-depressive effect. Icculusioso 00:42, 3 May 2007 (UTC)
thread_title:  Other possible SNRIs? 

message: ...er- although I have not graduated yet and am far from an expert I am well aware of selective norepinephrine re-uptake inhibitor (SNRI) antidepressants, but have never heard of the same abbreviation referring to "Serotonin-norepinephrine re-uptake inhibitor" type antidepressant drugs.  I believe this may be a misunderstanding on the part of the author and hope a kind professional/academic might find the time to either authenticate, edit, merge or delete this article accordingly.
SNRI is a valid acronym but if one wants an all-inclusive acronym, go with SSNDRI . It should be used along with a needed discussion of dopaminergic re-uptake inhibitors (SDRIs). Buccleugh (talk) 19:42, 20 June 2013 (UTC)
replies: text: Per MEDMOS, I'm not certain if that change would be appropriate. A PubMed search for "SSNRI" yields only 4 results, and only 2 of these are in English. (This is compared to 2546 for "SSRI" and 184 for "SNRI".)  --Arcadian (talk) 02:46, 22 May 2008 (UTC)
thread_title:  SERATONIN or SELECTIVE? 

message: The text currently says that a blood test every six months is sufficient for the prevention of liver failure with nefazadone, but I don't think that's correct. I think the liver failure tends to occur very rapidly. There is extensive damage in the abscence of a prodrome of gradually increasing serum liver enzymes. Psydzl (talk) 18:15, 11 February 2008 (UTC)
thread_title:  Nefazadone liver failure 

message: It would be nice with a history section, telling when the drug was developed, tested, taken into use, etc. And how widespread it's use is. Is it e.g. taking over the role of SSRI? 84.238.87.77 (talk) 09:32, 15 February 2009 (UTC)
thread_title:  When and how used? 

message: This is not my area of expertise, but it's confusing to say Tramadol is an SNRI, by including it in the list of SNRIs, and then to say, in Contradindications, that Tramadol is contraindicated with SNRIs. If Tramadol is contraindicated with other SNRIs, it would be more clear to just say that. Hananekosan (talk) 02:01, 13 August 2009 (UTC
Tramadol has other pharmacological issues that need an extended discussion:  tramadol's primary metabolite binds to selective opiod receptors in the brain. I recommend mention of tramadol on this page, with link to the separate tramadol page for discussion. There, explain the SRI interaction in more detail. Better, use two acronyms: SRI and NRI on this page to eliminate any confusion. Buccleugh (talk) 19:29, 20 June 2013 (UTC)
thread_title:  Tramadol information confusing/needs clarification 

message: I propose merging Discovery and development of dual serotonin and norepinephrine reuptake inhibitors into this article, since it is well written and far more comprehensive than this article. Any objections? SmartSE (talk) 00:02, 12 November 2010 (UTC)
replies: text: Wikipedia is not a place to post assignments… Yes, they are contributing great material, but they can just as easily refer their professor to the previous version of the D&D article before it was merged. All that information is retained in the edit history. I read through the discussion you linked and it seemed the main point against merging is producing undue weight on the D&D of the drug in the merged article, which I think is a valid concern, but I'd still rather see it merged. If nothing else, Discovery and development of dual serotonin and norepinephrine reuptake inhibitors can be moved to Development of serotonin-norepinephrine reuptake inhibitors, given a small blurb in this article with a "for more on this topic" link to the development article. ~rezecib (talk) 18:15, 18 November 2010 (UTC)
thread_title:  Merger proposal 

message: Made word, punctuation, and grammar changes to improve clarity and emphasis.
Victorsteelballs (talk) 11:44, 25 May 2012 (UTC)
thread_title:  Second paragraph 

message: Strattera was listed as an SNRI in the last paragraph with Wellbutrin but it is just an NRI so I took it out. Also, I took out the comma after "studies done" in that same paragraph because I didn't think it was needed (but I could be wrong).
Dmitri12 (talk) 07:19, 8 November 2012 (UTC)
thread_title:  8. Edit 

message: The hatnore referring to the SNRI thinktank is a broken link, and I am not sure if I should remove it or change it to a new name if one exists. Rarkenin (talk) 20:26, 3 January 2013 (UTC)
thread_title:  Hatnote 

message: It has been almost 9 months since it was agreed to merge this article with the discovery and development article and nothing has been done. When is the merger going to take place?
* Finally done on 2014-03-05, but an expert will need to review it. -- P 1 9 9  ✉ 14:30, 5 March 2014 (UTC)
thread_title:  When is the merger going to happen? 

message: * Change the header "Types" to something more specific such as "Pharmacotherapies" or "Medications" 
* Combine the drugs listed under "Types" into one table to help with continuity when reading. Right now the beginning portion is paragraph form and the later portion is a table. 
* Update the "Medical Issues" column with additional FDA indications for each medications and consider changing the title "Medical Issues" to "Indications" to make it more specific and clear.  
* Add more information on stigma and public perception of using drugs such as SNRIs 
Kendallkehr (talk) 22:22, 16 October 2019 (UTC)
thread_title:  CP133 2019 Group 22 proposed edits 

message: Part 1
The group's edit did improve the article. The goal of editing is to 1) provide updated information 2) ensure the article is organized so that specific information can be easily found and understood. 
The group did update information which included updating medication indications (addition of social phobia) and the number of FDA approved SNRI’s. They also supplemented information regarding side effects (bleeding and serotonin syndrome) and placed them under helpful subheadings so they were easier to find. Further, they edited the table under "Medications" to include notes originally listed elsewhere in the article. This helped streamline the information.
I believe the group had achieved the goal of editing.
Part 2
There were no signs of obvious plagiarism. No phrases sounded awkward or inconsistent to the authors' manner of writing. 
Celiahoang (talk) 05:46, 4 November 2019 (UTC)
thread_title:  Group 22 Peer Reviews