Talk:Aciclovir

message: iochemically inaccurate - the Aciclo-GTP form is an inhibitor because it is incorporated into nascent DNA resulting in chain termination. SOMETIMES w
hile the residue incorporated will be the GM--68.45.23.238 (talk) 03:44, 24 March 2013 (UTC)
replies: text: Consider it done. JFW | T@lk 20:32, 21 Dec 2004 (UTC)
thread_title: Untitled

message: Needs a proper structure representation rather than just a 3D image--ChemSpiderMan (talk) 17:41, 26 January 2008 (UTC)
replies: text: The image was removed by someone who probably thought "aciclovir" was a misspelling :P Fvasconcellos (t·c) 22:11, 26 January 2008 (UTC)
thread_title:  Needs a structure image 

message: The tautomer depicted in the figures of this article is different from the one listed by CAS. Which one is wrong? --Itub (talk) 14:52, 12 February 2008 (UTC)
thread_title:  Wrong tautomer? 

message: Will short term use of Acyclovir cause positive urine drug screens?--Lndbwn (talk) 17:43, 17 July 2008 (UTC)
thread_title:  ? positive urine drug screens 

message: is acyclovir's inhibitory action through impairment of thymidylate kinase and acts as a competitive inhibitor of normal triphosphate nucleotides thus, can someone clear this up for me?  —Preceding unsigned comment added by 193.1.229.15 (talk) 17:21, 31 May 2009 (UTC)
thread_title:  thymidylate kinase 

message: "Since acyclovir can also be incorporated into cellular DNA, it is a chromosome mutagen, therefore, its use should be avoided during pregnancy". I don't think this is correct. I happen to know that physicians do prescribe aciclovir during pregnancy because an herpes infection can be lethal to the newborn child. Also, aciclovir has a pregnancy category B3 (Au), B (VS) which means it's relatively safe.  —Preceding unsigned comment added by 130.89.139.9 (talk) 15:00, 8 October 2009 (UTC)
replies: text: http://www.ncbi.nlm.nih.gov/pubmed/8308511 http://www.cdc.gov/mmwr/preview/mmwrhtml/00022071.htm http://pregnancyregistry.gsk.com/acyclovir.html - seems to be effectively the case that it's fine if the benefits outweigh the risks and there isn't much (if any) real evidence of risk even in very high doses. Maybe somebody should fix that. --Streaky (talk) 01:08, 8 June 2012 (UTC)
thread_title:  Pregnancy 

message: This chemical was originally synthesized by Gerty Elion. I'm pretty sure it wasn't isolated from a sponge.  — Preceding unsigned comment added by 96.244.146.76 (talk) 01:49, 4 March 2012 (UTC)
thread_title:  Isolated from a sponge? 

message: Did you look at the source in question?  Doc James (talk · contribs · email) 02:24, 8 March 2016 (UTC)
replies: text: But this is the easier to access source "Even with the highest maternal dosages, the dosage of acyclovir in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants" http://www.drugs.com/breastfeeding/acyclovir.html Doc James (talk · contribs · email) 02:27, 8 March 2016 (UTC)
replies: text: thanks that is great.  I don't have acess to that pocket guide not even through a university medical library.  appears very handy tho! Jytdog (talk) 02:41, 8 March 2016 (UTC)
replies: text: Good to have a second source to back these things up and one which is easier for our readers to check. Doc James (talk · contribs · email) 03:14, 8 March 2016 (UTC)
thread_title: Breastfeeding

message: I found an interesting article in The Los Angeles Times that speaks to the distinction between Zovirax cream and Zovirax ointment.  It also speaks to Canadian vs. American pricing.  Something to consider for inclusion.  This is from Newspapers.com and comes in two parts:
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--User:Ceyockey (talk to me) 03:30, 24 June 2018 (UTC)
thread_title:  Cream vs. Ointment - source for consideration