Talk:Central tolerance

message: On merge with central tolerance: I don't think so. At the moment it looks attractive simply because both are stubs. But if there was a decent coverage of this topic then immune tolerance would be a massive article (with 30 000 peer-reviewed articles written on it, the topic is huge and varied). I think immune tolerance should basically remain an overview article, with links to the specific forms of immune tolerance, such as central tolerance, negative selection, regulatory T cell conversion, oral tolerance, etc etc). Sad mouse 16:10, 13 December 2006 (UTC)
thread_title: Untitled

message: Seeing as the proposed merger with Immune tolerance failed a while back, this article needs to be expanded to include the intricate detail. Otherwise it will be redundant, duplicating information in the immune tolerance article.
I don't think I have the expertise in this area to do it, I think we need an expert! 
Snellios (talk) 18:21, 18 May 2008 (UTC)
thread_title:  Expansion 

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thread_title:  External links modified 

message: As far as I have understood Thymic Epithelial Cells can express only self antigens (see below), so where would this "immunogenic antigen" come for the positive selection? I guess the idea is that if T cell cannot bind MHC at all (no matter what antigen it presents) it will not be positively selected.
Cheers,
H
Thymic Epithelial Cells
Annual Review of Immunology
Vol. 35:85-118 (Volume publication date April 2017) 
First published online as a Review in Advance on February 10, 2017 
https://doi.org/10.1146/annurev-immunol-051116-052320
Thymic Positive Selection
Following pre-TCR signaling, DN T cell progenitors proliferate and differentiate to generate a large pool of cortex-resident double-positive (DP) thymocytes. These cells have a short, 3- to 4-day lifespan rescued by αβTCR signaling caused by interactions with self-peptide/MHC complexes on cTECs. This process of positive selection generates both MHC class I–restricted CD8+ and MHC class II–restricted CD4+ cells that migrate out of the cortex and enter the medulla (Figure 4a). The properties that enable cTECs to support positive selection are still only partly understood. However, several studies have identified cTEC-expressed genes involved in controlling the processing and presentation of self-antigens, indicating cTEC specialization involves provision of a particular self-peptide array. For example, unlike most other cells, cTECs display constitutive autophagy activity, a process that results in the degradation of intracellular proteins (Figure 4a). In some experimental settings, the intrathymic generation of CD4+ SP thymocytes was altered in Atg5−/− thymus transplants compared to wild-type grafts, suggesting a role for autophagy in cTECs during the intrathymic selection of CD4+ T cells (96). In contrast, although expression of the endocytic receptor CD205 also defines cTECs, thymic selection occurs normally in CD205-deficient Ly75−/− mice (97), indicating that its putative role in the uptake of apoptotic thymocytes as a source of self-antigens is not required.  — Preceding unsigned comment added by 149.203.250.229 (talk) 17:04, 16 April 2018 (UTC)
thread_title:  Positive T cell selection figure incorrect?