Talk:Fetal hemoglobin

message: Hi everyone. I am a final year Life Sciences student who's doing a module called Science Communication. I will be editing the page quite frequently until the 17th of April as part of my assignment (please see above). My aim is to make the topic accessible to someone with a basic scientific knowledge and I will try to address the issues raised on this page to the best of my ability. Please feel free to let me know anything that I could add or change to improve the main article. Thanks! Sciencingabout (talk) 15:11, 5 March 2020 (UTC)
thread_title:  New Edits - educational assignment 

message: fetal hemoglobin is said in the text to be composed of two gamma and two alpha subunits.  the current picture shown in the article seems to show 2 subunits (each 7 alpha helices.)  is this a discrepancy?Wilgamesh 19:10, 1 November 2005 (UTC)
replies: text: I have the hardest time making heads or tails of those 3D ribbon diagrams of proteins, but I think you're right. It doesn't look nearly busy enough to be hemoglobin (compare with the image in the adult hemoglobin article). Could it be a single gamma subunit? (the part that makes fetal unique from adult) Hopefully the original author (or someone else who knows) will come along to clarify. Potatophysics 11:41, 27 January 2006 (UTC)

text: I believe the PDB I used to generate that image contains one alpha and one gamma subunit for a total of two subunits (i.e. one-half of a complete HbF protein). Should there be a PDB that represents the complete (i.e. all four subunits) protein, that one should be used instead. --David Iberri (talk) 12:15, 27 January 2006 (UTC)
replies: text: I have prepared a new image with the correct structure (tetramer) and I have uploaded to Wikimedia Commons as a new version of this. I guess it will be replaced automatically here in some time. --AngelHerraez (talk) 12:43, 10 February 2016 (UTC)
replies: text:  I think it's been rectified already. I will try to just highlight the 4 subunits and heme groups as the current image seems quite crowded. Sciencingabout (talk) 14:50, 5 March 2020 (UTC)
thread_title: fetal

message: # Hemoglobin structure and function
# Hemoglobin F fact sheet
# Fetal hemoglobin [doc]
All these links are dead, is it possible that someone could rectify this? —The preceding unsigned comment was added by Jameshrh (talk • contribs) 16:45, 10 May 2007 (UTC)
thread_title:  Dead Links 

message: Someone needs to seriously clean up structure and genetics.  Pretty sure there are not two genes for the gamma subunit on chrom. 11.(I don't want to change it as I am only 95% sure)   There is one gene for beta and one for gamma.  The alpha subunits however do have two genes per chrom.  I think the confusion is the original writer may have mixed up alpha and gamma?? maybe? Either way I added a sentence that says beta is on 11 too.  —Preceding unsigned comment added by 132.192.12.5 (talk) 01:45, 21 February 2008 (UTC)
thread_title:  Structure and genetics 

message: "and in the newborn until roughly 6 months old"
"fetal hemoglobin is nearly completely replaced by adult hemoglobin by approximately the twelfth week of postnatal life"
These 2 quotations from the first 2 paragraphs seem to contradict each other directly, does anyone know which is correct?  —Preceding unsigned comment added by Murdochious (talk • contribs) 19:36, 26 October 2008 (UTC)
thread_title:  Fetal hemoglobin persistence? 

message: Hello everyone. I was just curious if it was known why we switch from the more efficient fetal hemoglobin to normal hemoglobin. Does the fetal hemoglobin have any disadvantage over the adult variety? It seems odd for us to have this complex switching process for something to get WORSE as we get older, doesn't it? If there are any theories about this, I think it might be a good idea to add them here somewhere. JonathanHopeThisIsUnique (talk) 03:49, 6 February 2015 (UTC)
thread_title:  Possible new info