Talk:Eicosanoid

message: HI moderator, what the hell is up with the picture? It's completely messed up. A good diagram would succinctly illustrate the synthesis of different eicosanoids, but this really detracts from the page. Thankyou  —Preceding unsigned comment added by 86.13.74.231 (talk) 03:16, 25 July 2009 (UTC)
thread_title: Untitled

message: I think that there is a third way of arachidonic acid metabolism, called epoxygenase.
:Yes, there is, the EETs, via the Cytochrome P450 path. I'd noted it but haven't read enough about it to say anything interesting. I've added a link for it, but there's nothing there yet. I also added a link to a future article on Neuroprotectin D, which is AA derived. Does anybody know more about the EETs? Particularly, does anybody know if they only come from AA, or is there an EPA derived subfamily for them too?David.Throop 15:02, 12 March 2006 (UTC)
thread_title: EETs

message: This page looks good. I've never studied this topic, so there's not much that I can say about it. It might be nice to add some diagrams of molecular structures. I know that Canvas is a good program for this, but I won't be able to draw them any time soon. Do you know anything about the receptors for these hormones? I'm going on a Wiki-vacation, so I won't be available for more input for a while. Keep up the good work! AdamRetchless 08:15, 4 May 2004 (UTC)
replies: text: My source has quite a bit on the receptors, but they are quite specific for leukotrienes, prostacyclin etc. I thought it would be better to include this in the related articles, rather than on eicosanoid proper. <BR>JFW | T@lk 09:28, 4 May 2004 (UTC)
thread_title: General discussion

message: Someone asked for cleanup, because:
This article is a very good piece of work and shows a lot of research.  
But let me offer a correction.  It repeatedly states that all eicosanoids are derived from arachadonic acid. 
This is incorrect.  The series-2 prostaglandins (PG) and thromboxanes (TX) are derived from arachadonic acid.  
The series-1 PG and TX are derived from Gamma-linoleic acid through the DGLA intermediary.  
The series-3 PG and TX are derived from EPA.  I'm not sure about the prostacyclins and the leukotrienes.  
Also, arachadonic acid has other uses in the body besides eicosanoids, e.g. as a substrate for the endocannabinoids.''
:This is not good use of cleanup. Cleanup is when the fact are correct but presented clumsily. If you think the facts are incorrect, fix it! JFW | T@lk 20:51, 26 October 2005 (UTC)
thread_title:  Cleanup 

message: This article seems to be more or less accurate, but it needs to be properly referenced.--Virulent 78 13:49, 4 February 2006 (UTC)
replies: text: I'll find a few, but with M.W. King's site linked I guess we don't need the  template anymore. JFW | T@lk 05:16, 5 February 2006 (UTC)
thread_title: References?

message: There are two diagrams (figures 1 and 2) in 
*  (.pdf format)
that I'd really like to have for the Eicosanoid page.   I've read a lot of eicosanoid papers and these are by fat the best diagrams I've seen.
 They need to be updated a little – some more research has come in since they were published. 
Is anybody listening who is a good graphic artist and would someone like to work with me on this? – David.Throop 23:22, 10 January 2007 (UTC)
thread_title: Request for Help drawing some Pictures

message: I've brought material from Essential fatty acid interactions; it's a better fit here, I think. 
I've put Ciar's pictures into a single figure and added captioning.  I've put the list of receptors in a table, and added another table of eicosanoid medicines.  Introduced a section on eicosanoids in inflammation.
I used the wikitable template, which is mostly good.  But the body text runs right up against the table (in my browser, Firefox.)  If anybody can jiggle the handle on the tables so they don't do that I'd be obliged.David.Throop 15:00, 13 January 2007 (UTC)
thread_title: Major Updates

message: Excellent work. As a note for the future, using the Bookmarklet as detailed on this page makes adding references as easy as cut and paste. It adds into your browser as a button you can click and it pops up a window summarising the PubMed entry you are looking at in the correct format to paste into Wikipedia. TimVickers 18:08, 13 January 2007 (UTC)
thread_title: Hi there

message: Help!  Near the end of the Nomenclature section, I disambiguated "cofactor" to "cofactor (biochemistry)", but we now have the phrase "protein cofactor" linking to a definition which specifically states "non-protein"!  It seems to me that either the Eicosanoid page or the cofactor (biochemistry) page needs to be edited by someone with knowledge of whether cofactors can be protein or not.  (perhaps the cofactor page needs to say "usually non-protein"?) --Coppertwig 17:24, 27 January 2007 (UTC)
replies: text: A quick trip to scholar.google.com showed that most scholarly works were calling FLAP an enzyme or a co-enzyme.  So I made that change. David.Throop 17:55, 27 January 2007 (UTC)
replies: text: Well done. --Coppertwig 01:17, 31 January 2007 (UTC)
thread_title:  protein cofactor? 

message: I drew the diagram of eicosanoid synthesis. If there are adjustments to be made, please let me know. I can also release the sxd file (OpenOffice.Org) for others to fiddle with. JFW | T@lk 20:43, 29 January 2007 (UTC)
thread_title:  Image 

message: Someone mentioned above that arachidonic acid is not the only source of eicosanoids.  The first diagram at the top of the article shows only arachidonic acid, so maybe it needs to be changed (or labelled as being an example).  --Coppertwig 02:45, 30 January 2007 (UTC)
thread_title:  Only arachidonic acid? 

message: Changing the reference style has greatly improved the page.  I have added the following:



To convert from single-column to two-column format (it looks much nicer) but alas this will not display as such in every browser.  (I believe it works in Firefox).  If someone knows how to make it display in two columns in all browsers, please tell me how! Thanks in advance István 17:48, 30 January 2007 (UTC)
thread_title: References format

message: Look at how I reformatted your numbered list.  :-) More detail here.
When I wrote this whole paragraph, it was more or less a direct quote from Fritsche.  Maybe I should just quote him directly.  There's a quotation template that I'm looking around for...
01:01, 2 February 2007 (UTC)
thread_title:  Quoting on eicosanoids and omega-3 

message: In the first paragraph:
:Eicosanoids have a short half-life, ranging from seconds to minutes.  Dietary antioxidants inhibit the generation of some inflammatory eicosanoids, e.g. trans-resveratrol against thromboxane and some leukotrienes. Most eicosanoid receptors are members of the G protein-coupled receptor superfamily; see the Receptors table.
I suggest adding at least one or two sentences between the first and second sentence and at least another one or two between the second and third, if appropriate information can be found, splitting into more than one paragraph if necessary.  This would serve two purposes:  first, to make this part longer than the corresponding part of the introduction which should logically be a mere summary of it;  secondly, to guide the reader in the flow of ideas from one of these sentences to the next.  Each of these sentences seems to me to be a sufficiently different topic from each other than perhaps each should be in a separate paragraph, with some other information added to fill out the paragraphs. --Coppertwig 13:41, 2 February 2007 (UTC)
replies: text: yeah, I know.  Right now, the paragraph is just a catch-all for snippets of text that I didn't know what to do with.   For right now I'm going to leave it alone.  Once we've reworked the Biosynthesis material, it will be clearer what needs to be covered here.  But feel free to take a swipe at it.  You (or anybody else tuning in) might try reading Simopoulos and see if you could summarize what he says.  Alternatively, edit Talk:Eicosanoid/to_do. Make a list of what points should be made in the sub-section and I'll try to come up with the text.  David.Throop 16:07, 2 February 2007 (UTC)
thread_title:  Connect the dots in "function and pharmacology" 

message: Substituted at 14:14, 29 April 2016 (UTC)
thread_title: Assessment comment

message: Preferred IUPAC names are preferred systematic names of specific organic compounds when the systematic IUPAC nomenclature gives several possibilities. The name eicosanoid is a trivial name, not a name constructed according to IUPAC nomenclature (-noid is not part of IUPAC nomenclature), so the IUPAC preference of icosa- over eicosa- as a prefix meaning "twenty" is not relevant here. Therefore, I deleted the information Preferred IUPAC name: icosanoid froim the article.--Biologos (talk) 15:38, 27 June 2016 (UTC)
thread_title:  "Preferred IUPAC name: icosanoid" not true 

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thread_title:  External links modified 

message: What is GPLA? Should it be DGLA (dihomo gamma linoleic acid)? Wisapi (talk) 21:50, 18 January 2018 (UTC)
thread_title:  cPLA2's acts specifically on AA, EPA and GPLA??