Talk:Hemocyanin

message: Incorrect citation regarding prostate cancer. So removed this.   — Preceding unsigned comment added by Mke.sala (talk • contribs) 01:18, 6 September 2014 (UTC)
thread_title: Citation re: Immunotherapeutic effect of Concholepas hemocyanin in bladder cancer

message: This article states that hemocyanins differ from hemoglobins in that they do not bind oxygen co-operatively. On the contrary, many hemocyanins are extremely co-operative, in fact, many are much more co-operative than most hemoglobins. Some are the most co-operative binding proteins known. The conformation changes that accompany the increased (and sometimes decreased!) oxygen affinity as oxygen binds to these very large multisubunit proteins is  at least partially known for some hemocyanins. Also hemocyanins may respond to other allosteric effectors in addition to oxygen 
Also the statement that hemocyanins bind oxygen with one-fourth the effeciency of hemoglobin is misleading. A single polypeptide subunit of hemocyanin binds one molecule of oxygen, as does one polypeptide subunit of hemoglobin. Vertebrate hemoglobins are made of 4 polypeptides; arthropod hemocyanins are made of at least 6 polypeptides and can have up to 48. Thus a single arthropod hemocyanin can carry 6 to 48 molecules of oxygen since they have 6-48 subunits, 1.5 - 12 times the number of oxygen molecules carried by a typical vertebrate hemoglobin. 
(See van Holde, K.E., and K.I. Miller, 1995, Hemocyanin, Academic Press, NY.)
--67.84.174.97 21:21, 15 August 2005 (UTC)
thread_title: August 2005

message: A suggestion.
There will be a nice story linking Hb with haemocyanin, I expect, but don't know the details.  Can anyone remark on it here or in a general article on them, or link appropriately? Midgley
:I don't think these two oxygen carriers are related, its likely as case of Parallel_evolution or  Convergent_evolution, as multiple celled organism grow larger they needed as means to transport oxygen. --BerserkerBen 14:45, 29 January 2006 (UTC)
thread_title:  Evolution of metalloprotein Oxygen carriers 

message: Would it be at all relevant to mention anywhere that Vulcans are stated to have copper-based blood? 65.185.124.35 (talk) 21:47, 1 April 2012 (UTC)
thread_title:  Pop culture 

message: I would be interested to see references on where haemocyanins occur, as clues about how it evolved. I will say what I know.
First of all, molluscan and arthropod haemocyanins are distinct proteins; a common origin is possible but not conclusive.
Haemoglobin is found in the clam Arca pexata; the distribution of haemoglobin is quite widespread.
Haemocyanins and haemoglobins both occur among arthropods. Haemocyanins are found mainly among arachnids and the subclass Malacostraca of the 
Crustacea. The arachnids include the horseshoe crub and tarantulas of the genus Eurypelma. The latter haemocyanins have been extensively 
investigated. Crustaceans include many crabs and losters; their proteins are homologous to those of the arachnids but there is a characteristic 
difference. I do not know how extensively haemocyanins occur among spiders in general, or about scorpions.
I do not know of haemocyanins in the insects, but I think haemoglobins do occur. Scott Tillinghast, Houston TX (talk) 09:10, 15 February 2013 (UTC)
thread_title:  Occurence of haemocyanins vs haemoglobins in arthropods and molluscs 

message: One could easily say that the haemocyanins are in competition with haemoglobin. Also that haemoglobin generally has the upper hand.
The 2 types of haemocyanin seem to occur in one phylum each: Arthropoda and Mollusca. Haemoglobin is found in several phyla: Chordata, Arthropoda, Mollusca, and Annelida (such as earthworms). Scott Tillinghast, Houston TX (talk) 03:37, 16 February 2013 (UTC)
thread_title:  Competition 

message: I moved the sentences about animals having these proteins into a second paragraph, and that enabled me to bring up the difference between molluscan and arthropod hemocyanins.
As you can see, my interest is primarily in arthropod hemocyanins. Someone who is interested in molluscan hemocyanins could add something to the second paragraph, maybe even split it into 2 new paragraphs. Scott Tillinghast, Houston TX (talk) 00:27, 11 March 2013 (UTC)
replies: text: Your edits look quite good to me, and seem to have improved the clarity of the article.  Thanks for being bold and making them.  Cheers.  N2e (talk) 15:14, 11 March 2013 (UTC)
thread_title:  Revised opening section 

message: My citation for Svedberg's discovery of hemocyanin is on p. 1 in the review in 'Advances in Protein Chemistry.'
Why include the abbreviated title if you give the full title? Scott Tillinghast, Houston TX (talk) 20:24, 13 March 2013 (UTC)
thread_title:  Citation 

message: Molluscan hemocyanins have clearly been found among cephalopods, gastropods, bivalves, and chitons. I would be interested to see references for 
the smaller classes Solenogastres, Monoplacophora, and Scaphopoda.
I am curious about the gastropod family Pleurotomariidae. Could it antedate the divergence of Prosobranchia, Opisthobranchia, and Pulmonata? Scott Tillinghast, Houston TX (talk) 20:50, 14 March 2013 (UTC)
thread_title:  Molluscan classes 

message: It is asserted than hemocyanins are found primarily in cold-water crustaceans and a source is cited. On the other hand they are often found in land arthropods, especially spiders and scorpions. Many of the latter are semi-tropical or tropical. This issue should be reconciled. Scott Tillinghast, Houston TX (talk) 23:36, 31 March 2013 (UTC)
thread_title:  Structure and mechanism 

message: This article should indicate if this substance was ever used as a fabric dye.  — Preceding unsigned comment added by 24.76.231.228 (talk) 19:16, 2 April 2017 (UTC)
thread_title:  Use as dye? 

message: “Mice primed with C. concholepas before implantation of bladder tumor (MBT-2) cells. Mice treated with C. concholepas hemocyanin showed antitumor effects: prolonged survival, “
The first part doesn’t convey any meaning for me.  Is this the remains of a previous edit?  I’m on mobile in safari, so maybe it’s a caption for something that’s not showing?  Not certain. Elgordon (talk) 03:20, 3 December 2018 (UTC)
thread_title:  “Mice primed with” Typo?