Talk:Pyelonephritis

message: Trimethoprim is NOT a suitable treatment for pyelonephritis.  Although it works very well for cystitis when the causative bacterium is susceptible, it cannot work when the kidney is infected in cases of pyelonephritis.  This is because it acts to block folic acid synthesis in bacteria.  The bloodstream, which supplies the kidney, is a rich source of folic acid.  Any bacteria that are present in the kidney are supplied with folic acid, overcomimg the block imposed by trimethoprim.  The same is true for the combination of trimethoprim and a sulphonamide (co-trimoxazole): sulphonamides also act to block bactieral folic acid synthesis.
Micjh
: Still according to  it is an acceptable alternative to fluoroquinolone for susceptible organisms. --WS 20:23, 8 January 2006 (UTC)
thread_title: Trimethoprim

message: The article suggested that PBC was a predisposing state for pyelonephritis. Searching PubMed I can only find some Japanese case reports that suggest the coliforms cause PBC through molecular mimicry, but nothing on an increase of UTIs. It bears noting that PBC is often treated with immunosuppression, and that this independently increases the risk for UTIs. JFW | T@lk 20:52, 25 July 2007 (UTC)
thread_title:  PBC 

message: http://journals.lww.com/greenjournal/Citation/2008/03000/ACOG_Practice_Bulletin_No__91__Treatment_of.37.aspx
ACOG have issued a guideline for UTI/pyelonephritis in non-pregnant patients. Sadly, the document is not free (which is a bit silly, given that guidelines are meant to be disseminated). JFW | T@lk 22:03, 29 December 2008 (UTC)
thread_title:  Guideline 

message: Pyelonephritis is a description of inflammation of the renal pelvis and kidney. It is a consequence of an ascending urinary tract infection, not the infection itself. Pyelonephritis can be caused by a number of things.  —Preceding unsigned comment added by 159.92.232.193 (talk) 16:16, 2 May 2011 (UTC)
replies: text: It's not a symptom, but one could call it a syndrome. At the same time, it is usually caused by infection so it is not wrong to refer to it as an infection. JFW | T@lk 15:21, 5 June 2011 (UTC)
thread_title:  Pyelonephritis is a SYMPTOM, not an infection.  

message: This reference entered the article after the merge with xanthogranulomatous pyelonephritis, and  reinserted it after I took it out. I cannot see a precedent for using this as a source in any other medical articles. Occasionally we make specific references to Dorland's, but only when a definition is required and no other sources are available (e.g. in hypopituitarism). JFW | T@lk 15:21, 5 June 2011 (UTC)
thread_title: A short course in medical terminology

message: I was looking for a secondary source to replace Czaja2007, and stumbled upon the 2010 IDSA guidelines (doi:10.1093/cid/ciq257). This is an absolutely perfect source, and it can probably replace quite a few primary research studies that we are currently using. I'll be reading this over the next day or two, and hopefully do something useful with it. JFW | T@lk 06:22, 6 June 2011 (UTC)
replies: text: Thanks for finding this excellent, up-to-date source which reflects a global approach to the subject. I have just finished reading it, and I see this source as being useful in replacing the inline citations for paragraph #1 of the ==Management== section. I would like to add though that IMHO the pyelonephritis article goes into far too much detail with respect to the dosing of antibiotics, coming dangerously close to giving medical advice. Seems to me it should be more general, simply stating which antibiotics are most useful under which set of circumstances. For example, we might include a statement such as:  What are your thoughts? DiverDave (talk) 01:53, 10 June 2011 (UTC)
thread_title:  Hey, Dave! 

message: Eh? How can πήληξ, pḗlēx, become "pyelum"?  — Preceding unsigned comment added by 83.226.139.228 (talk) 20:01, 1 January 2014 (UTC)
thread_title:  πήληξ – pyelum 

message: doi:10.1056/NEJMcp1702758 JFW | T@lk 13:03, 4 January 2018 (UTC)
thread_title:  NEJM review 

message: https://www.nice.org.uk/guidance/NG111 JFW | T@lk 21:44, 11 June 2019 (UTC)
thread_title:  NICE about antibiotics