Talk:Neurotransmission

message: i added a much more detailed user freindly description of synaptic transmission and added a example of neuro impulses such as a heart beat, then some more links and a new reference.
Roy Stanley (talk) 20:57, 13 January 2008 (UTC)
thread_title:  expanding this article 

message: This section is sorely lacking in information. In fact, such a topic might warrant its own article. For now, I moved some relevant info from Dale's principle (now known to be false). I also removed the statement that cotransmission "...functions to multiply effect complexity manifold". This statement isn't too meaningful to the layman, mainly because it needlessly uses the word "manifold". Also, it implies that the purpose (i.e. function) of cotransmission is to multiply the complexity of effects - something that, in the strictest sense, can never be proven. A more accurate statement might be: "Cotransmission allows for more complex postsynaptic effects, and thus more complex communication between neurons." (In fact, I think I'll add that statement.) Fuzzform (talk) 23:44, 29 September 2008 (UTC)
replies: text: According to Gordon Shepherd, Dale's principle is widely misunderstood.  What Dale was trying to say (according to Shepherd; I haven't read Dale) is basically that a neuron does the same thing at all of its synapses, not necessarily that it only releases one transmitter.  Anyway, I think your edits have improved this article -- please continue at will. Looie496 (talk) 01:26, 30 September 2008 (UTC)
replies: text: Can someone add the needs expansion tag? cause this page is really missing information  —Preceding unsigned comment added by 24.203.202.14 (talk) 00:15, 17 February 2010 (UTC)
thread_title:  Cotransmission 

message: This section is far too vague in its ramifications, and far to specific in its machinery.   —Preceding unsigned comment added by 63.112.0.74 (talk) 00:47, 15 February 2011 (UTC)
replies: text: Well, yes, actually the whole page would benefit from expansion. --Tryptofish (talk) 21:33, 15 February 2011 (UTC)
thread_title:  Summation 

message: Question: When summing inputs, does anyone here know how many (or what percentage of) input signals are required to cause a neuron to fire and pass the signal on to other neurons?  
Suggestions: If known, please extend the statement in the 3rd paragraph of the article to read something like, "Each neuron receives as many as 15,000 connections from other neurons, at least ____ of which must be stimulated before causing it to fire." 
Put an example in the Summation section like the following to illustrate this amazing concept to non-professional readers.  I'd do it, but I don't know what numbers to put into the blanks: "When you prick your finger with a pin, instead of the single signal that you might think is transmitted, as many as ____ nerves are stimulated to fire their axons and thus stimulate the dendrites of ____ more neurons, thus initiating a series of signals of the sensation.  Only when more than ____ of the dendrites of one of the receiving neurons are stimulated will it fire its axon and pass the signal on to the neurons that it can reach.  Before the signal of that single pin prick reaches your brain, up to ____ nerve cells may be involved.  The number of neurons then involved in processing the signal inside your brain that causes you to say, "ouch," is incalculably large."
Discussion: I am not an expert and don't even know where to look for answers to this (the cite links 2,3,& 4 didn't work behind my ridiculously strong firewall, but I'm not going to delete them in case it's just me.) I also don't know if "stimulated" or "fire" are the right terms to use. LeeMost (talk) 20:24, 4 November 2011 (UTC)
replies: text: I'm sympathetic to the idea, but in practice it isn't so easy.  Cerebellar Purkinje cells can be fired (several times) by a single input from a climbing fiber; hippocampal CA3 pyramidal cells can be fired by two or three inputs from mossy fibers.  A cortical pyramidal cell requires about 100 excitatory inputs to fire it in the absence of inhibition, but when inhibitory interneurons are active (as they usually are), the number can approach a thousand.  In short, it's very difficult to make meaningful statements in a completely general context. Looie496 (talk) 21:56, 4 November 2011 (UTC)
thread_title:  How many input signals? 

message: Hello fellow Wikipedians,
I have just added archive links to  on Neurotransmission. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20060219105238/http://web.lemoyne.edu:80/~hevern/psy340/graphics/summation.jpg to http://web.lemoyne.edu/~hevern/psy340/graphics/summation.jpg
*Added archive https://web.archive.org/20060913221459/http://www.cameron.edu/~gabrielr/PHYCH4/sld055.htm to http://www.cameron.edu/~gabrielr/PHYCH4/sld055.htm
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
Cheers.—cyberbot IITalk to my owner:Online 07:05, 13 January 2016 (UTC)
thread_title:  External links modified 

message: Isn't there a word & concept for the spreading out of neurotransmitters away from & consequently influencing neurons adjacent to and other than the immediate target neuron? If so, what is that word/phrase, and couldn't this concept be included in this article? (I see the article on neuromodulation, and I'm not sure that's the same thing?)  UnderEducatedGeezer (talk) 22:28, 13 August 2019 (UTC)
replies: text: It's "volume transmission". --Tryptofish (talk) 23:07, 13 August 2019 (UTC)
replies: text: Thank you Tryptofish, I just found that just while you were responding! I was going to say 'never mind, I just found it', in Neuromodulation and make a link to it, as Neuromodulation#Volume_transmission, but you beat me to it! I didn't read far & sufficient enough, sorry. I also didn't realize the article section could be linked so simply as you did.  UnderEducatedGeezer (talk) 23:19, 13 August 2019 (UTC)
thread_title:  "spreading cloud" neurotransmission?