lflage/wiki-talks huggingface dataset:
Talk:Contact inhibition

message: The term "Contact Inhibition" was coined by Prof. Michael Abercrombie in a paper published
in Experimental Cell Research in the early 1950s.  The term refers specifically to the
inhibition of locomotion of cells, not their growth or division. Contact doesn't "arrest"
either cell growth or cell locomotion; what occurs is a slowing or redirection of locomotion.
I wish that oncologists really did use differences in contact inhibition to distinguish
between normal and cancerous cells. If somebody found a way to do that, it would be an
important breakthrough.  It is possible that there really are consistent differences
in the degree to which normal versus cancer cells are inhibited in either their growth
or their invasive locomotion.  This article states a plausible guess as if it were
a known fact.
The paragraph about cells growing in flasks dying out because of contact inhibition
is mistaken.  Some dying-out phenomena actually occur ("Hayflick's Phenomenon") but the
evidence is that these result from non-replacement of telomeres. I suggest this article 
should either be improved (made consistent with the published refereed journals)
or removed.  It is perpetuating some major factual mistakes on an important medical
subject. 
If you want, I can give you a time-lapse video sequence of one cancer cell undergoing
contact inhibition after touching a non-cancerous cell. 152.2.14.111 (talk) 23:31, 29 November 2008 (UTC)
thread_title: Untitled

message: Good Afternoon, I am editing this cell biology stub for a class project for drsusan1968.  — Preceding unsigned comment added by Jchiu2016 (talk • contribs) 19:35, 28 November 2016 (UTC)
thread_title:  Editing This Stub
Talk:Stromal cell

message: Is the last sentence raises more questions than it answers.  I'd fix it if I knew the answer but I don't ... Anyone else?
Here it is as it stands today 9/22/10:
"The loss of these stromal growth factors when the cancer moves throughout the body prevents the cancer from invading other organs."
It seems some information is missing regarding the effect of basal cell carcinomas on stromal cells.  In short this makes basal cell carcinomas non-malignant tumors, not cancer.  I don't think that's true.  It's called "skin cancer".  —Preceding unsigned comment added by Davea0511 (talk • contribs) 03:23, 25 September 2010 (UTC)
replies: text: Basal cell cancers are generally harmless (unlike melanoma). I think this is an interesting observation and would like to see it within the context of a larger discussion of the role of stroma in cancer and ALSO a citation. It makes total sense to me, and I'm assuming it's correct. But it needs a reference and some context.   Eperotao (talk) 20:24, 4 February 2013 (UTC)
thread_title:  eh? 

message: are Stromal cells multipotent? can someone please add this?  —Preceding unsigned comment added by 128.180.4.137 (talk) 09:04, 6 May 2009 (UTC)
thread_title:  multipotent? 

message: Hi everyone,
I noticed that there is another article specifically for MSCs. This article here should probably be more general about stromal cells and then we could just link to the detailed article about MSCs. The part about the immunoregulatory mechanisms of MSCs would also need a lot more editing but we could instead just delete it here and expand it in the MSC article. What do you think? Explorative Alpaca (talk) 09:18, 26 April 2022 (UTC)
thread_title: redundant content with MSC article
Talk:K562 cells

message: I added the last section of the article involving the cell cycle of K562 cells and their regulation. I made this contribution, because I felt as though the cell cycle and cell cycle regulation is an important aspect in understanding cancer cells and cancer cell lines, because malfunctions in the cell cycle are what generally lead to cancer. 
There is still room for improvement on this article, such as rewording and reorganizing the introductory material, as it is rather hard to follow. In addition to this, there is room for more introductory material to be added about K562 cells such as their characteristics and uses. Diagrams and pictures would also help in displaying this information to help visual learners, as well as to break up the amount of text that is present in the article. Aport007 (talk) 22:17, 17 November 2016 (UTC)
thread_title: My Contribution to the Article

message: Hi, I noticed a lot of improvements to this article but one thing that could really help is breaking this information up into paragraphs so that it's easier to read. I also noticed a number of citations following this line "In addition to this method, Chinese medicine using the Eriocaulon seiboldianum plant is being researched and displaying a role in the inhibition of Aurora kinases." But it only gets a brief mention. This article probably doesn't need any more information but it could help expanding on that last line and talking about the experimental research.  — Preceding unsigned comment added by Kabio401 (talk • contribs) 17:51, 17 November 2016 (UTC)
thread_title:  Suggestions? 

message: Thank you for your suggestion. When I originally typed the entry, it was in paragraphs, however, when I put the work into wiki it made it all one big paragraph and I could not figure out how to correct that. Perhaps I could check with someone to learn how to fix that. Second, I could definitely try to add more to that research to expand on it a little to prevent the feeling of an abrupt ending, however, I could keep going and going on that information. I will try to elaborate and find a good place to stop. Thank you again fro your feed back Aport007 (talk) 22:12, 17 November 2016 (UTC)
thread_title: Thank You

message: I was able to separate the entry into paragraphs as it was intended to be. I hope this helps the flow of the article as you were saying. Aport007 (talk) 00:31, 18 November 2016 (UTC)
thread_title: Update
Talk:Chondroblast

message: "Once [chondroblasts] embed themselves into the cartilage matrix, they grow the cartilage matrix by growing more cartilage extracellular matrix rather than by dividing further."
What about interstitial cartillage growth? Does that not happen precisely by chondrocytes dividing further inside the matrix? 128.214.138.144 (talk) 12:19, 3 November 2022 (UTC)
thread_title:  Interstitial growth
Talk:Gastrodermis

message: This seemes like it could be a very good article, if only it was longer. swat671 (talk) 06:47, 9 December 2007 (UTC)
replies: text: Yes, I wasn't planning on adding additional information, just removing invalid stuff. It does need further work. Yirch (talk) 04:51, 21 September 2023 (UTC)
thread_title:  Too short 

message: Compliments to Yirch for the new page rewrite. Article is sweet. Voidlighthouse (talk) 04:02, 21 September 2023 (UTC)
thread_title:  Rewrite September 2023
Talk:Hemocyte (invertebrate immune system cell)

message: Altered the reference to Matheson's novel "I Am Legend" to the entry for the film, as the word does not appear in the novel or its wiki entry. Bustter (talk) 03:24, 4 May 2008 (UTC)
thread_title:  Matheson had no "hemocytes" 

message: The article only has information on the Fruit fly & Mosquito hemocytes, it should add more info on what it does in other animals, if this will be what is in the article. General info on hemocytes is limited & should be increased, as the info on hemocytes across animals is limited to a single paragraph stretching just one line & 3 sentences. This article is a stub, so it should be lengthened. --Wiki43215 (talk) 02:36, 29 June 2021 (UTC)
thread_title:  Article lacks content
Talk:Ion channel linked receptors

message: These are exactly the same things as Ligand-gated ion channels. I think that it would be uncontroversial for me to merge this page into that one (and there is useful content here that actually should be merged). Does anyone object? --Tryptofish (talk) 19:05, 8 January 2017 (UTC)
replies: text: with this edit: . --Tryptofish (talk) 23:10, 21 March 2017 (UTC)
thread_title:  Merge
Talk:Art critic

message: It's already too long..The key word is Famous art critics; not just a list of art critics..Maybe a list of art critics can be created as a separate linked article, but not here...Red ink names do not belong until there are articles about those particular critics...Modernist (talk) 18:05, 8 April 2009 (UTC)
thread_title: The list

message: It says "often because their art was in a style not yet understood or favored.". I think that could be worded better. The work in that case was understood as having no significance at the time.SunRiddled (talk) 12:02, 24 March 2011 (UTC)
thread_title: Not sure about this

message: Should it be mentioned that art critics in the past relied on print publications whereas today notable critics, such as Jerry Saltz, are doing more work online than in traditional print?SunRiddled (talk) 14:08, 8 April 2011 (UTC)
thread_title: Differences in distribution
Talk:Repeat induced point-mutation

message: * RIP - is not N.crassa specific. Found in Fusarium, Magnaporthe, Aspergillus
* Citations would include 
** Cambareri et al Description of RIP
** Selker 1990 Review
** Dean at al 2005 Magnaporthe has RIP
** Cuomo et al 2007 Fusarium has RIP
** Braumann et al 2008 Aspergillus and Penicillium (Eurotiales) may have RIP
Jason_Stajich (talk) 07:29, 1 June 2009 (UTC)
thread_title: Untitled
Talk:TRAIL

message: * Which cells produce TRAIL, and under what circumstances? 
* Does TRAIL act on the receptors of the cell that produced it, or on some other cell? 
* Is TRAIL a transmembrane protein, or is it released into the extracellular fluid? (The article states that it has "characteristics of a transmembrane protein".) 
AxelBoldt (talk) 04:01, 8 February 2013 (UTC)
replies: text: Identification and characterization of a new member of the TNF family that induces apoptosis. says " TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate." - Rod57 (talk) 14:27, 17 February 2016 (UTC)
thread_title: Questions
Talk:Canfield, Ohio

message: How is is simultaneously a wealthy suburb and a city with a 23% poverty rate?
—Preceding unsigned comment added by 24.150.56.120 (talk • contribs) 23:01, 8 June 2007
: The two aren't mutually exclusive. "Wealthy" is a subjective assessment based, I believe, on comparison to the surrounding communities, while the poverty rate is presumably an objective assessment based on comparison to some explicit standard. But since the first term (and indeed, the entire "Culture" section) cites no sources for its information, I have tagged it as unreferenced. ~ Jeff Q (talk) 23:43, 8 June 2007 (UTC)
thread_title:  Wealth and poverty 
Talk:Coenobium (morphology)

message: If Volvox is an example of a coenobium, then the number of cells must not be fixed; Volvox vary in size & can have up to 50,000 cells.  I deleted "fixed" from the lead to be on the safe side, but maybe we need more nuance here (eg "especially those with a small, fixed number of cells").  Or maybe the examples should be edited instead.  This will need attn from someone who knows more than I do. Gould363 (talk) 17:02, 11 June 2014 (UTC)
thread_title:  Number of cells?
Talk:Mechanotaxis

message: I tried to revise this article by explaining it better but it seems a bit hopeless. From what I understand, the movement indicated here is present in cell groups which move together in a set direction or pattern, such as muscle tissue. This may help anyone trying to adapt this article if what I gathered from the stub is correct.... Carsinmotion 05:34, 11 June 2007 (UTC)
thread_title: Untitled
Talk:Horizontal integration

message: The Gap only appeals to middle-aged folks? Damn. I'm too young to be middle aged! Vorenus 19:39, 14 February 2007 (UTC)
thread_title: The Gap

message: Can someone fix the code at the start of this article? 84.9.147.16 (talk) 16:22, 20 January 2008 (UTC)
thread_title: Lede

message: How is the media section in any way related to the article? I believe it needs mass restructuring and finding the validity of sources.  —Preceding unsigned comment added by Darktsunami (talk • contribs) 08:38, 15 December 2009 (UTC)
thread_title: Mass media

message: Linked image of horz/vert integration contains a label that is likely too regionally specific to be relevant globally and thus is potentially confusing in framing the concept. On the Vertical axis, the term for "Garage Owners" in the US is something like Auto Dealers. Don't know the range of difference from country to country.75.130.209.128 (talk) 21:14, 29 March 2014 (UTC)
replies: text: The image definitely could be improved, at the moment its unclear what the different coloured circles signify.Jonpatterns (talk) 12:29, 5 February 2016 (UTC)
thread_title: Image

message: Difference between horizontal and Vertical 
A horizontal acquisition is when a company acquires another company which is in a direct
or in same industry. For ex. One clothing company acquire another clothing company. 223.17.5.92 (talk) 15:29, 13 May 2022 (UTC)
thread_title:  Difference between horizontal and vertical
Talk:Dictyate

message: "There are a lot of mRNAs that have been transcribed but not translated during dictyate." Should this read, "Many mRNAs are transcribed but not translated during dictyate."?
Also, what is 'a lot of mRNAs'? Does this mean no mRNAs are translated or that a large subset are not translated? The distinction seems relevant.  — Preceding unsigned comment added by 128.84.127.99 (talk) 21:42, 18 February 2019 (UTC)
thread_title:  Translation halt - too vague?
Talk:Girard, Ohio

message: I swear, if another Dylan Breese mention occurs on this page, I will masturbate. --Daysleeper47 15:07, 19 March 2007 (UTC)
thread_title:  Dylan Breese 
Talk:Cohesin

message: The article states:
"It is not clear how the cohesin ring links sister chromatids together. There are two possible scenarios:
# Cohesin subunits bind to each sister chromatid and form a bridge between the two.
# Since cohesin has a ring structure, it is able to encircle both sister chromatids.
Current evidence suggests that the second scenario is the most likely. Proteins that are essential for sister chromatid cohesion, such as Smc3 and Scc1, do not regulate the formation of covalent bonds between cohesin and DNA, indicating that DNA interaction is not sufficient for cohesion.[3] In addition, disturbing the ring structure of cohesin through cleavage of Smc3 or Scc1 triggers premature sister chromatid segregation in vivo.[9] This shows that the ring structure is important for cohesin’s function."
In fact, the Cell paper linked does not discuss the hypothesis that cohesin bind each chromatid and tether them together, and thus the reference does not prove that Smc3 and Scc1 don't bind cohesin to DNA. Additionally, the way this is written suggests that hypothesis #1 means that cohesin covalently bonds to the chromatids, which is both inaccurate and a misunderstanding of how proteins generally bind to DNA through intermolecular interactions, not chemical bonds.
The paper does address the second half of the paragraph. It essentially shows that cleaving Scc1 and Smc3 or disrupting Smc3's coiled coil domain results in cohesin's dissociation from chromatin, but does not interfere with subunit binding. This indicates that the cuts/modifications do not destabilize the complex, but they do break the supposed ring structure and allow the complex to be released. They show that this causes a deficiency in sister chromatid cohesion in vivo, although they don't take that much further.  — Preceding unsigned comment added by 71.192.102.252 (talk) 21:58, 13 July 2019 (UTC)
thread_title:  Interpretation of reference and explanation of findings is fundamentally incorrect
Talk:Protein S

message: Are they the same protein? OMIM says: "S-protein is not to be confused with protein S (176880)". see--Miguelferig (talk) 09:15, 12 September 2018 (UTC)
thread_title:  Protein S / S-protein / vitronectin 

message: doi:10.1111/jth.15025 JFW | T@lk 21:48, 5 September 2020 (UTC)
replies: text: Laboratory testing: SSC recommendations. doi:10.1111/jth.15109 JFW | T@lk 15:02, 22 March 2021 (UTC)
thread_title:  New insights
Talk:Antifreeze protein

message: Including roles of charged amino acid, coil structure and length?  — Preceding unsigned comment added by 130.216.44.28 (talk) 20:14, 27 February 2017 (UTC)
thread_title: Worth adding a section on structural-activity relationship?

message: The section on mechanism and action is a little misleading.  Not all AFPs work like this.  --Phoenix Hacker (talk) 23:21, 23 April 2011 (UTC)
thread_title: Mechanism and Action

message: Suggested file to add to this article. — Cirt (talk) 16:56, 6 October 2015 (UTC)
thread_title:  Antifreeze Proteins by Bill Nye for National Science Foundation 

message: — Assignment last updated by Ahoy6337 (talk) 18:13, 28 November 2022 (UTC)
thread_title: Wiki Education assignment: Advanced Ecology and Evolution

message: How it was discovered? How genes were discovered? please expand. AXONOV (talk) ⚑ 08:25, 26 July 2023 (UTC)
thread_title:  History of discover
Talk:Podsolisation

message: Most of the info for Podsolisation is already in Podsol, perhaps a merge or redirect is needed? Or possibly someone just needs to sift through and seperate the information into the 2 different pages. Namdra 19:47, 14 February 2007 (UTC)
replies: text: Maybe, but this article is poorly written, with parts of it bordering on gibberish. •Jim62sch• 19:23, 26 April 2007 (UTC)
thread_title: Podsolisation and Podsols

message: Why doesn't the link to the German :de:Podsolierung show up in the interlanguage links of the mobile version? Hobbitschuster (talk) 18:30, 5 May 2022 (UTC)
thread_title:  Inter language links
Talk:Inner Loop (Washington, D.C.)

message: I think that this article is overlinked please see Wikipedia:Manual of Style (links)#Overlinking and underlinking: what's the best ratio? --Philip Baird Shearer (talk)  —Preceding comment was added at 10:19, 17 January 2008 (UTC)
thread_title: links

message: Why is I-266 counted as part of the Inner Loop? It was, of course, part of the freeway plan, but it wouldn't make sense to consider it to be part of the Inner Loop proper. Also, come to think of it, the East Leg (295) isn't described on the article, or listed in the infobox. Roadsguy (talk) 00:19, 7 September 2014 (UTC)
thread_title:  266?
Talk:Protein complex

message: Ribosome is not a multiprotein complex, and not an enzyme. Ribosome is an RNA-protein complex (scaffold is mainly rRNA) and due to the catalytic site position, ribosome is a ribozyme. Should this article be moved to "biomolecular complex"? Because then one could include any stable complex determined by computational or structural means and may include DNA (nucleosome=DNA + protein), RNA (ribosome, spliceosome, telomerase,...= RNA + protein), protein, lipid (transmembrane protein complexes usually have some essential lipids bound), sugars (glycosylation of various proteins in complexes),... Kazkaskazkasako (talk) 10:23, 15 October 2013 (UTC)
thread_title: Ribosome in the lead

message: An article Protein stoichiometry has been proposed for deletion. The text makes no sense, but I thought that the attached list of measurement methods may contain useful sources, so rescued it here as a backup.
*Absolute Quantification (AQUA)
*Multiple Reaction Monitoring (MRM)
*Fluorescence microscopy
*Step-wise photobleaching of dye-labelled subunits (photobleaching)
*hydrophobic photolabeling (HyPLa)
*peptide-based mass spectrometry
*proteomics-based mass spectrometry
*cell fusion and single molecule imaging
*isotope-coded mass spectrometry
--Wotheina (talk) 05:51, 8 August 2021 (UTC)
thread_title:  List of papers about stoichiometry determination
Talk:ADAMTS13

message: JFW | T@lk 23:15, 2 July 2007 (UTC)
thread_title:  Activity vs antigen level 

message: JFW | T@lk 08:13, 15 July 2007 (UTC)
thread_title:  Podocytes 

message: New research also shows ADAMTS13 deficiency in Hemolytic Uremic Syndrome (PATHOMA.COM) Avkrules (talk) 19:53, 27 February 2012 (UTC)
thread_title:  E. coli O157:H7 

message: doi:10.1111/jth.13953 JFW | T@lk 16:33, 21 January 2018 (UTC)
thread_title:  Role in sepsis coagulopathy 

message: doi:10.1182/blood-2018-02-791533 JFW | T@lk 16:54, 30 August 2018 (UTC)
thread_title:  Testing
Talk:The Barlow Roman Catholic High School

message: In general, no page should be titled using a definite article (Such as "The") please review WP:NC(S). Adam McCormick 18:44, 17 August 2007 (UTC)
replies: text: I understand but "The" has to be included because this is the official name of the institute! Onnaghar  tl | co 15:58, 24 August 2007 (UTC)
replies: text: It's a question of most-used name. Do the vast majority of people use "The" when referring to the school? Adam McCormick 16:05, 24 August 2007 (UTC)
replies: text: Yes, especially in local media. It is referred to as the "The Barlow" in shortened form. Onnaghar  tl | co 14:29, 25 August 2007 (UTC)
thread_title:  Move
Talk:Queen of Cups

message: This should better relate to other articles, tarot, queen of hearts, etc.  Mathiastck 19:52, 14 February 2007 (UTC)
thread_title: Untitled

message: Parsa and myself have been have been placing the NPOV tags on the cards. See the talk page at Talk:The World (Tarot card) Since tarot cards were not designed for the occult, the placement of "occult" stub tags does constitute POV and ignores tarot's gaming heritage. These individual card pages offer nothing more than occult speculations and perhaps should be deletedSmiloid 00:54, 19 March 2007 (UTC)
thread_title:  NPOV 

message: I want this to be added to the article: "The cup, a chalice, that she's holding seems more to be a religion not a cup."
Cup is water element. Consciousness is water that is in a cup. Love consciousness. This is not original research. You pour water from the cup. You pour consciousness.WillBildUnion (talk) 20:18, 13 June 2010 (UTC)
replies: text: No, that is original research until you cite a reliable source.  What you provided just now is nothing but your own interpretation, and Wikipedia does not accept the personal interpretation of any editor.  Ian.thomson (talk) 21:03, 13 June 2010 (UTC)
replies: text: Well I could get a source but this article is not important to me. While it seems it has become important for you to stalk my edits, and seems, to revert my edits if it does not go with your knowledge or opinion. Half of wikipedia would be deleted if every sentence in wikipedia would be demanded to be sourced. What I wrote is not my own interpretation. You just want to be hard for me.WillBildUnion (talk) 21:10, 13 June 2010 (UTC)
replies: text: Properly citing sources is an important aspect of Wikipedia.  As is assuming good faith.  Holding every editor I come across to the guidelines is nothing personal against you.  You are the one that has avoided citing your sources.  Ian.thomson (talk) 21:56, 13 June 2010 (UTC)
thread_title:  Cup / chalice / religion 

message: I am suggesting that the information on the individual card pages for the cups suit would be better placed in Suit of cups pageTetron76 (talk) 17:11, 2 March 2011 (UTC)
thread_title: Merge to
Talk:The Oddities (professional wrestling)

message: If this is the most amount of info on the whole earth about the oddities then shoot me in the head. I think we can do a little better than this people. C'mon, are you kidding me? This is like nothing. I can't be the only one one who KNOWS that there is a TON more info on the oddities and it's members than what is listed here.  —Preceding unsigned comment added by 75.132.0.255 (talk) 08:59, 13 February 2009 (UTC)
thread_title:  MORE EVERYTHING 

message: How can I upload a picture of them that I have? TheYeahYeah (talk) 00:21, 4 July 2022 (UTC)
thread_title:  Needs the picture of em