Talk:Α-Methyltryptamine

message: I removed a purely speculative statement, which said that AMT acts as a stimulant because of "similarities in chemical structure to amphetamine". First of all, it is not that similar; amphetamine is a phenethylamine, and AMT is a tryptamine. Second of all, this drug is an MAOI, which means that it inhibits ALL monoamines to some extent. Third, levels of serotonin (which tryptamines primarily affect) have been shown to have some control over dopamine levels. Lastly, I would just like to say that the edits to this article have unfortunately been dominated by recreational drug users, rather than anyone who knows the first thing about what these drugs do in terms of biochemistry. I'll keep an eye on this article.
Fuzzform 02:33, 9 February 2007 (UTC)
replies: text: Hi Fuzzform, I for one welcome our biochemist overlords. 8-P No, but seriously, I added a quasi-minor edit which I would like checked by someone with deeper knowledge. It used to read Like many other tryptamines, at sufficient dosages α-MT a psychedelic hallucinogen. I turned it into "α-MT acts as a psychedelic hallucinogen". The most trivial edit would have been to add "is" rather than "acts a"; yet, naively, it seems to me that a substance belongs or not to a certain class regardless of the dosage at which it shows the relevant effects. What do you think? If it should read differently, please make it so. Apwith (talk) 14:47, 14 September 2009 (UTC)
thread_title: Some comments about effects

message: αMT is reported to be a schedule 8 controlled drug in Australia, though this is unconfirmed. What the hell is this sentence supposed to mean? It can't be too difficult to find what the law says.--90.179.235.249 (talk) 21:12, 23 June 2012 (UTC)
thread_title:  unconfirmed?? 

message: It would be appreciated if somebody could offer some insight if they have knowledge of how this drug is metabolised and how it might interact with, not only other drugs, but also every day foodstuffs, particularly such that involves the P450 system.
The article currently states the following...
It acts as a very weak, non-selective and reversible inhibitor of the enzyme monoamine oxidase (MAO), but...
:::this is unlikely to be very significant if at all with typical doses.''
A 'typical dose' is extremely subjective unless it has been tested in appropriate conditions. I'm not going to provide for a basis of my assumptions because any source would likely be of a commercial nature (as there is little proper research to source from), and this kind of subject would do well to avoid linking to potential vendors, but I have come to assume that a moderate oral dose is given as being between 24 and 32 milligrams. This, as a matter of opinion, is actually significant when it comes to drug metabolism, particularly when the P450 system is relevant.
Given that uninformed or ill-informed persons might encounter this drug on the street, I feel it prudent to provide factual information about the dangers one might face should they consume this compound. Suggesting that the MAO activity is not concerning requires reasoning. I am more inclined to suggest that the inhibition of MAO and other enzymes is indeed significant but I can't back that up, hence my bringing the matter to the table.
:This paper appears relevant. Is there a german speaker with access who could give a translation?Testem (talk) 08:23, 7 October 2013 (UTC)
replies: text: I have removed the "expert attention" tag for the time being. This section needs a lot of improvement but it needn't all be delivered by an "expert", if there really is such a thing for a drug with so little contemporary study. This article is top of my list for improvement - it is entirely likely that it will still need expert attention afterwards but we will cross that bridge when we come to it. Testem (talk) 15:33, 8 October 2013 (UTC)

text: Mere Mortal (talk) 02:17, 30 October 2012 (UTC)
thread_title:  Metabolism 

message: I appreciate that drug-related community forums can provide for some rather interesting information and vantage points, but is it really appropriate to link to them on an article such as this? When it comes to pharmacology, should relevant information be valid then it would serve best within the article itself than to be externally linked. Mere Mortal (talk) 16:57, 21 August 2012 (UTC)
replies: text: Sometimes such sources are the only sources of information, especially when it comes to novel drugs. Where little is known or where forum discussion is inherently important as a source I think it does have value. Outside of these cases WP:MEDRS should be used. Testem (talk) 15:37, 8 October 2013 (UTC)
thread_title:  Links to Forums 

message: I have marked this article as unbalanced because it is focusing too much on psychological side-effects rather than those relating to standard pharmacology. Mere Mortal (talk) 18:16, 21 August 2012 (UTC)
thread_title:  
Unbalanced Article
 

message: Please stop using this article as a reference point when discussing with patients their use of this substance. This article is not a valid source for NHS purposes, using it in an official capacity would be extremely unprofessional and potentially dangerous. I personally do not feel that it is appropriate for a patient's medical record to point out that "Wikipedia states aMT is a very weak MAOI", whereas it is actually quite effective at inhibiting this enzyme, and possibly others. If I could cite my own claims then I'd amend the article without hesitation, but I'm afraid that I don't have any such sources to use. Make no mistake, though, that aMT can cause severe problems with regards to metabolism, blood pressure, insulin levels and who knows what else, if mixed with the wrong drugs or foodstuffs. A hypertensive crisis is a very real possibility where aMT is used incorrectly so please maintain extreme caution, particularly if there are intentions to prescribe an SSRI, which would require a cool-off period of at least two weeks, possibly longer. Thank you.
:Mere Mortal (talk) 12:29, 25 July 2013 (UTC)
thread_title:  Note to General Practitioners 

message: This condition becomes apparent as the primary effects wear off after around 36 hours, which can continue for as long as a week after cessation of long-term usage. In severe cases, this can result in fainting. Not recommended whilst using heavy machinery, driving vehicles or indeed any other activity which requires a constant safety check. Any reputable links to this subject would be greatly appreciated.
:Mere Mortal (talk) 04:50, 7 December 2013 (UTC)
thread_title: [[Orthostatic_hypotension#Medication|Orthostatic hypotension]]

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thread_title:  External links modified 

message: I haven't found an appropriate reference but self-experiment has shown that (R)AMT is hallucinogenic while (S)AMT is purely an entactogen. If the isomers are overlayed with the ring-substituted phenethlamines & LSD itself (the 8-nitrogen overlaying the basic amine of the PEAs and indolamines you will see it is true for all). The subjective effects are further quantified in the action of 𝛂,7-dimethyl tryptamine. The (R) isomer is equipotent to (R)AMT (as 5HT2a ligand) while the (S)isomer is equipotent with (S)MDA as VMAT-2- ligand producing and SRI/DRI action. As with MDMA, the mixture has a 'magic' that is better than that of either isomer alone.
 I do not know if the above information is of any scientific or legal import. The latter because the US CsA act would fail since the effect of (S)𝛂,7-dimethyl tryptamine is unlike it's 'parent' i.e. AMT so it would fail to be 'substantially similar to or more potent than <the parent controlled substance>'.  — Preceding unsigned comment added by 81.99.74.135 (talk) 09:41, 31 May 2018 (UTC)
thread_title:  Enantiomers 

message: "A British teenager died after consuming 1 g of αMT in August 2013."
So, depending on what you call an average dose, ~30-50x overdosage?  At least 10x if you're aiming high on what anyone reasonably would take?  So it's still safer than Tylenol...   I really think these articles should quote the reasons used to ban various drugs, rather than just blank statement of laws.  For example, from the US ban paper: 
Emergency designation of AMT as a Schedule I controlled substance by the Drug Enforcement Administration occurred shortly after the Miami-Dade Medical Examiner reported the death of a 22-year old college student who ingested a large amount of AMT (4).  Prior to death, the deceased advised his roommate that he was "taking hallucinating drugs" and as a result had "discovered the secret of the universe". The roommate reported that the deceased was shaking and sweating profusely, waving a knife, and threatening to commit suicide. The roommate tied the deceased to the bed for his own protection and left him to "sleep it off".  Approximately 12 h later, the roommate discovered the deceased lying in bed unresponsive. 
The moral of this story is drugs don't kill people, drugs get banned for killing people after psychopathic roommates tie people to beds and kill people.  At least the roommate faced charges for all this, amirite?  *crickets*  --A Shortfall Of Gravitas (talk) 19:41, 2 February 2021 (UTC)
thread_title:  Cited overdoses and reasons for bans 

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