Talk:Hyaluronic acid

message: I saw hyaluronic acid in 20mg capsules available as a dietary supplement at a health food store recently.  However, the label on the bottle made no claims.  What are the purported benefits of oral hyaluronic acid supplementation?  Have any studies been conducted on this?  --LostLeviathan 15:33, 31 August 2005 (UTC)
replies: text: 2 yrs later?? No wonder he couldn't find the publication on Medline in 2006!! It wasnt published until 2 years after his comment... 65.240.135.194 (talk) 01:07, 17 September 2023 (UTC)
thread_title:  Use as a dietary supplement 

message: I noticed that the HTML links were not cited at the end of the article.  I'm fairly new to this and have been using footnotes "ref" -style to cite. I changed to this method from ignorance of how to cite HTML otherwise - sorry if I've offended a previous editor.Lystrablue 05:22, 26 December 2006 (UTC)
thread_title: References

message: The current image of the hyaluronan structure on this page is incorrect. Hyaluronic acid is a repeating disaccharide with the following structure: GlcNAc(beta1-->4)GlcA(beta1-->3) 
The current image of the hyaluronan is not according to this structure. 
Source: Nomenclature of glycoproteins, glycopeptides and peptidoglycans, IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN)
http://www.chem.qmul.ac.uk/iupac/misc/glycp.html
Dabalk 16:07, 8 April 2007 (UTC)
replies: text: You're right. It is wrong. Good catch. --Herb West 03:30, 27 December 2006 (UTC)
replies: text: It's now corrected.  --Ed (Edgar181) 19:55, 19 July 2007 (UTC)
thread_title:  Structure of Hyaluronan 

message: In using HA for horses, I have noticed that there are 2 different types used on the lables.  I am wondering what the differences are, and what the difference might be to how the 2 different types might be utilized by the animal?  One is Hyaluronic acid, and the other is Sodium Haluronate.  63.152.3.34 04:33, 16 March 2007 (UTC)
replies: text: They are essentially the same thing. Sodium hyaluronate is just a salt of hyaluronic acid. The standard preparation for injecting is HY-50 (see the references added to the article). There is another preparation which can be added to the horse's feed. We have ordered this for our horse, as a follow-up to the course of injections, but have not yet received it.AliasMarlowe (talk) 19:54, 1 April 2009 (UTC)
thread_title:  Does anyone know?  

message: In the cosmetic section, the article seems to imply that there are contra-indications for people on 'blood medication'. Does anyone know what this might mean? (It doesn't seem to be specific enough to make sense. E.g., blood thinners, or blood products (e.g., platelets)...?). If no one knows I'll look this up when I have time. bfigura (talk) 05:07, 17 August 2007 (UTC)
replies: text: Removed. I can find no studies confirming this, and neither can the FDA.  Feezo (Talk) 05:48, 17 August 2007 (UTC)
replies: text: It's back again - Dont know how or why. Rod57 (talk) 12:48, 28 August 2008 (UTC)

text: it says "Hyaluronic acid is a common ingredient in skin care products" but does not state what the benefits are supposed to be, or the reasons for using it.  What is it supposed to do when simply washed with? 2.31.164.76 (talk) 17:50, 13 February 2021 (UTC)
thread_title:  Cosmetic Applications 

message: Somewhere I heard that this compound is necessary in large quantity taken orally for a type of hand conditioning called "iron hand". IT was supposedly obtained in sufficient concentration from a diet consisting mainly of Japanese sweet potato, and Mexican wild yam supposedly has it in large amounts also. What truth, if any, is there to these statements? 216.82.142.13 (talk) 22:39, 30 April 2009 (UTC)
replies: text: You've got the wrong idea.  We don't answer questions, we find people with answers and cite them.  You could try the reference desk but you're better off trying google.  Very unlikely you'll find anything but if you do and it is reliable, please cite it.  WLU (t) (c) Wikipedia's rules:simple/complex 00:28, 1 May 2009 (UTC)
replies: text: Try Yahoo Answers.  Fuzbaby (talk) 04:34, 21 June 2009 (UTC)
replies: text: Now that's just cruel. No need to be mean. SCNR --92.202.107.73 (talk) 22:02, 15 December 2010 (UTC)
thread_title:  Martial arts hand conditioning, and presence in certain vegetables? 

message: Where did the word "hyaluron" come from? Who initially isolated & described the substance in the the scientific literature?  —Preceding unsigned comment added by 67.79.10.114 (talk) 21:49, 11 November 2009 (UTC)
thread_title:  Origin 

message: Well I've just gone through and read the page and I have a few bits I don't understand and a few bits I can't find links to for further explanation, so here are some questions.
What 'proteins' could be 'link proteins' in this sentence - are they 'special' in some way ?
* When aggrecan monomers bind to hyaluronan in the presence of link protein, large highly negatively-charged aggregates form.
What is 'petircellular' in this sentence - is it just a typo? for pericellular ??
* endocytosis of HA, which leads to HA catabolism in macrophages; and assembly of petircellular matrices from HA and proteoglycan.
In (for example) the sentence above Hyaluronic acid seems to be abbreviated HA - but that abbreviation is not clarified in the article (but I don't think I've misread that?). Do you think inserting 'and abbreviated HA' into the first line of the article would be a good idea ? So something like this:
*Hyaluronan (also called hyaluronic acid or hyaluronate, and abbreviated HA) is ...
To the layman (me) the whole first half of the section Hyaluronan#Medical_applications looks like and advert for Healon which I guess is a brand name? am I wrong - I'm going to insert a few cite note needed bits in there.
Is the word 'imbibe' correct in the sentence below - it seems 'non scientific' - but what do I know :)
*When aggrecan monomers bind to hyaluronan in the presence of link protein, large highly negatively-charged aggregates form. These aggregates imbibe water and... 
EdwardLane (talk) 16:26, 10 May 2011 (UTC)
thread_title:  Questions 

message: I created a red link for pp60(c-src), as I'm not sure what it is. Searching in wikipedia for pp60 I see List_of_MeSH_codes_(D12.776) and List_of_MeSH_codes_(D08) both contain these redlinks Oncogene_protein_pp60(v-src) and proto-oncogene proteins pp60(c-src)
but I don't know enough about Hyaluronan to be bold and change that redlink I made into this redlink proto-oncogene proteins pp60(c-src)
I dont even know what proto-oncogene means, so I'll leave tidying that redlink to someone else, while I go and read that page. Thanks. EdwardLane (talk) 16:22, 10 May 2011 (UTC)
thread_title:  Tidying the link for pp60(c-src) 

message: Hello fellow Wikipedians,
I have just modified  on Hyaluronic acid. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20110607112840/http://www.drugs.com/vet/hy-50-can.html to http://www.drugs.com/vet/hy-50-can.html
*Added archive https://web.archive.org/20080601040624/http://www.genitrix.co.uk:80/2008ProductsHorses-HY502.php to http://www.genitrix.co.uk/2008ProductsHorses-HY502.php
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—InternetArchiveBot (Report bug) 07:24, 21 July 2016 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Hyaluronic acid. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added  tag to http://www3.interscience.wiley.com.iiiprxy.library.miami.edu/cgi-bin/fulltext/119157843/PDFSTART
*Added archive https://web.archive.org/web/20141025043750/http://hyaluronicacidpowder.net/Segura_et_al_Biomat_2004.pdf to http://hyaluronicacidpowder.net/Segura_et_al_Biomat_2004.pdf
*Corrected formatting/usage for http://www.biomateria.com/bio_skin_3.htm
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 04:14, 7 April 2017 (UTC)
thread_title:  External links modified 

message: In addition to being injected as a wrinkle filler, etc., there is also topical use and dietary supplement use. I do not intend to write about because of COI (I have consulting clients with products). David notMD (talk) 16:13, 16 October 2017 (UTC)
thread_title:  Cosmetic uses 

message: I propose the one line "Approval" section be merged with "Medical uses".  I found them to be contradictory.  — Preceding unsigned comment added by Tsunami3 (talk • contribs) 18:40, 20 August 2018 (UTC)
thread_title:  Approval 

message: This is one of the most popular pages in Wikipedia:WikiProject Veterinary medicine's scope.  Very few editors watch WT:VET's pages, which means that questions may not be answered in a timely manner.  If you are an active editor and interested in animals or veterinary medicine, please put WT:VET on your watchlist.  Thank you,  WhatamIdoing (talk) 19:59, 11 January 2021 (UTC)
thread_title:  WP:VET 

message: According to my physiology textbook (Guyton and Hall Textbook of Medical Physiology 14th Edition, See page 23) hyaluronic acid is synthesized in the Golgi apparatus, however, the article states that it is made in the plasma membrane, so which is right?  — Preceding unsigned comment added by 37.239.20.3 (talk) 21:11, 11 May 2021 (UTC)
thread_title:  Site of synthesis? 

message: Having consulted Stern [2009], I am removing a "vague" tag.
I am changing text that used to read: "contributes significantly to cell proliferation and migration and also[vague] may be involved in the progression of ... malignant tumors.[6]".
To follow the cited author more closely, it now reads: "..., and is involved ....".
Stern doesn't really beat around the bush on this topic.
* p.5: "The deposition of HA ... confers motility ... correlating possibly with the movement of metastatic tumor cells." [Ok, fine, his cautious phrasing is slightly weak there.]
* p.6: He cautiously suggests that "... cancer cells emulate that point in the cell cycle when cells synthesize increased levels of HA, round up, detach from their substratum, and leave temporarily the social contract in order to divide. Normal cells then degrade that HA .... Cancer cells have learned to eliminate this step ... to continue to divide endlessly.", and he cites Itano et al. [2002], which I am adding to this wiki article. Skipping a bit, we still find a cautious "may": "In most cases, it may be the failure to remove the HA coat ... that promotes malignant cell growth and the development of cancer."
* p.7: He suggests that "HA developed late in evolution, at a time when stem cells had to move ... some distance ... for growth, proliferation, and differentiation.", a capability that was then "... commandeered by malignant cells."
* p.8: "Clinically, striking increases of HA in the serum of many cancer patients has also been well documented." He cites Manley and Warren [1987], and Wilkinson et al. [1996]
* p.9: "It is now widely recognized that HA is dramatically increased in most malignancies."
* p.12: Stern finishes with: "... the recognition that HA is ... at the core of such interactions in malignancy."
(I love his p.6 remark: "Cancer cells do not do unusual things, but do usual things at unusual times.")
John hanley parc (talk) 18:42, 3 April 2022 (UTC)
thread_title:  removing "vague" tag 

message: Isn't hyalos a Latin word? ὕαλος is the Greek term. 173.88.246.138 (talk) 04:02, 16 October 2022 (UTC)
thread_title:  Etymology