Talk:Methylene blue

message: Methylene blue is in dry pads that just before use are soaked with normal saline,
applied to a wound area that is resistant to healing it limits bacterial growth while
allowing the moist area to heal.
  Diabetic sores on or near feet in particular.
These pads  by Rx  only  — Preceding unsigned comment added by 71.9.22.214 (talk) 22:12, 10 October 2017 (UTC)
thread_title: Use in pads for wound healing

message: "methanamime" and "methenamine" are not the same, the former is meh590
 the latter is hexamethylenetetramine and is a constituent of Prosed DS. News flash: methylamine (MeNH2) is a corrosive gas at STP so it's unlikely to have been included as an API to say the least.
While either could be used to make methamphetamine (but not quite in the same way... ), and methylamine is certainly regulated, it seems highly unlikely that urised was taken off the market simply b/c it contains hexamethylentretramine. Unless you've got citations to back this up, then that assertion doesn't belong in the article. 
PS see the bottom of the linked page, methenamine hippurate does not have a DEA schedule if this information is accurate (it's a .gov address)
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cc299e8a-cf9a-4dc6-b6e6-972141e59296
Hell, unless methylene blue (the subject of this article) itself was the reason Prosed was taken off the market, then the section on urised/Prosed doesn't add much value here anyway.71.202.140.109 (talk) 11:28, 25 April 2012 (UTC)
thread_title:  discontinuation of urised 

message: At what temperature and/or pressure will it take to oxidize methylene blue?
:It's not a question of temperature or pressure - it depends on the chemical (redox) environment. An oxidant (like oxygen, or potassium permanganate) will oxidize it and turn it blue. A reductant (like 2-mercaptoethanol) will reduce it and turn it colorless. Why the question? Ignoramibus 05:24, 16 August 2006 (UTC)
thread_title:  Methylene Blue 

message: Why is there a prank listed in the article under uses? Firstly, it's topical, generally pointless/useless, and completely uncited content. Secondly, it's somewhat unsettling given the warning note under the medicine uses category. Not to mention that Methylene Blue is a WHMIS class D division 2 compound, and shouldn't be used as a prank on anyone at any volume regardless of it's purification. Whoever added this appears to condone potentially hazardous acts -- plz keep this sort of thing to your blog. Imho, it's really just disrespectful and stupid... even for Biochemist standards :P   --mark
:Well, I've got to agree with you about that "Pranks" section. I never went ahead to remove it because I thought it was just me who thought that stuff sounded stupid/dangerous (I tend to be a little overcautious with anything chemical...). As soon as I find some time I'll check that paragraph again and see if there's anything useful to save, then remove it. BTW, that info you mentioned about the methylene blue absorption sounds useful, you should add it to the article. Berserker79 07:02, 20 September 2006 (UTC)
thread_title:  Pranks? 

message: This warning may actually be quite prescient, but without any indication of the sources it is based on is of limited use or assistance. It is probably something of an over generalisation, and somewhat imprecise. The only circumstance in which methylene blue is likely to be dangerous in patients is when it is infused intravenously in large doses. As far as I am aware this is only done for the purpose of highlighting the parathyroid tissues during thyroidectomy, in order to avoid damaging them. The doses used are in the region of five to 10 milligrams per kilogram body weight, infused just before and during surgery. At such doses it appears Clear that it has various relevant pharmacological effects in humans, although from my research these appear incompletely documented and partially understood. It would appear to be a significant monoamine oxidase inhibitor, and that means it maybe capable of producing serious, and even fatal, serotonin toxicity if combined with any drug that has significant potency as a serotonin reuptake inhibitor.  My publication referred to above
has references relevant to this, and further material is, and/or will be very soon, available on my website.  Assistants in understanding the chemistry of this from those with appropriate knowledge would be most useful because patients may die as a result of imperfect understanding and knowledge concerning this. It may be of interest for others to know that in the brief interval of two weeks since my publication came on line, and since I added a note here, I have received two reports of SerotoninToxicity involving methylene blue. It is beginning to look as though it is significant issue that has hitherto been unrecognised. Wiki people can make a real contribution to patient care and safety, please communicate your information, and try to give original references wherever possible.Ken Gillman 00:40, 27 September 2006 (UTC)
replies: text: Thanks for pointing out the G6PD issue. I looked into it and sorry but I will have to correct you on this as I found that in fact it is people who are G6PD deficient who have issues. Well, maybe it was my mistake but reading what you said ("dangerous to people with the G6PD genetic variant") lead me to believe that having G6DP caused the problem, when in fact G6DP is the "cure" as it is an enzyme that prevents issues with MB. See: http://www.ncbi.nlm.nih.gov/pubmed/11048840 .. Wonder at what doses problems occur. 129.78.233.211 (talk) 06:06, 30 April 2013 (UTC)
thread_title:  Warning 

message: I know this is not a big deal, but this article was used as a source for a cre.ations.net article on how to make you urine blue. Delta Tango • Talk 23:54, 27 November 2006 (UTC)
thread_title:  This article mentioned 

message: UPDATE! The Prank page has added info. that this is a potentially fatal prank if done to the wrong person due to M-blue acting on Serotonin and some harmful interactions with other conditions. I'm going to go-back and see if this is still in the article, if it is, I'll add the "prank"-warning.  — Preceding unsigned comment added by Housewifehader (talk • contribs) 15:48, 6 June 2013 (UTC)
thread_title:  Pranks - moved from article 

message: The word "sklera" is used in the Medicine section. What does this word mean? A search of Wikipedia itself returns only this one reference and Google recognises it only as a non-English word but suggests it may be a misspelling of "sclera" - the 'white' of the eye. I suspect this is what the original author meant but as I am unsure I don't feel confident to make the change. 83.104.249.240 11:20, 27 March 2007 (UTC)
thread_title:  Sklera? 

message: Isn't the structure that is shown that of leucomethylene blue and not of methylene blue, since that has a cationic sulfur group?Mbdxe (talk) 11:00, 21 January 2008 (UTC)
thread_title:  Correct Structure? 

message: Residual Thiosulfate: All film shall meet the requirements for residual thiosulphate ion concentration as specified in ANSI IT9.1-1989; For Imaging Media (Film) -- Silver-gelatin type- Specifications for Stability, Section 6.4. The maximum allowable thiosulphate ion concentration is .014 grams per square meter. Testing for residual thiosulphate ion concentration shall be done by using the Methylene Blue method in accordance with ANSI/ASC PH4.8-1985; For Photography (Chemicals)-Residual Thiosulphate and Other Chemicals in Films, Plates and Papers- Determination and Measurement, Section 5. This test shall be conducted within two weeks of film processing and may be performed at the processing site or by an independent laboratory. All test results shall be documented.  —Preceding unsigned comment added by 74.70.144.191 (talk) 00:36, 30 July 2008 (UTC)
thread_title:  Methylene Blue test for residual thiosulphate in film processing. 

message: http://www.azcentral.com/news/articles/2008/07/29/20080729alzheimer-drugs0729-ON.html
I don't know how to do this wikipedia stuff. here is an article if anybody wants to do anything with this information.(68.2.134.151 (talk) 00:48, 30 July 2008 (UTC)
replies: text: I believe this calls for the creation of Rember (disambiguation) to distinguish between the two compounds.  Wish there was some information that hinted what type of compound this new 'rember' is. I've done a quick journal search and I can't find anything that clearly describes what it is. Oh well, the various AP news stories are enough to justify a stub for now. --VectorPotential Talk 12:18, 30 July 2008 (UTC)
replies: text: Eh, that's not right.  Rember ǂ Methylene blue, the redirect that took you here is slightly misleading. As best as I can tell Methylene blue is a component of 'rember' so my suggestion of a disambiguation page wouldn't make any sense.--VectorPotential Talk 12:23, 30 July 2008 (UTC)
replies: text: Now I'm not sure anymore, I think I'll wait for a published journal article before I make any more presumptions.--VectorPotential Talk 12:56, 30 July 2008 (UTC)

text: I've added a link in the article's 'see also' section to Rember. The new drug contains a form of methylene blue, but it is not exactly the same thing, so not exactly applicable to this article. A 'see also' link is probably most applicable at this time. Dr. Cash (talk) 14:48, 30 July 2008 (UTC)
thread_title:  Experimental Alzheimer's drug 

message: I think I'll pitch this one to WT:MCB and see if they think it should be a separate article from Methylene blue.--VectorPotential Talk 12:57, 30 July 2008 (UTC)
replies: text: I've added a link in the article's 'see also' section to Rember. The new drug contains a form of methylene blue, but it is not exactly the same thing, so not exactly applicable to this article. A 'see also' link is probably most applicable at this time. Dr. Cash (talk) 14:48, 30 July 2008 (UTC)
thread_title:  [[rember]] 

message: We have recently started my non-verbal Autistic son on Methylene Blue in hopes of seeing some improvement.  Anyone else out there experimenting as well?  —Preceding unsigned comment added by 76.179.201.217 (talk) 03:30, 1 March 2010 (UTC)
thread_title:  Autism and Methylene blue 

message: The article currently lists the ingestion of broad beans as a cause of Methemoglobinemia, but I cannot find any reference to such in either of the aforementioned articles. That statement could certainly use a source.  —Preceding unsigned comment added by Synetech (talk • contribs) 05:48, 8 June 2010 (UTC)
thread_title:  Broad Beans? 

message: The main page for methylene blue(MB) states that MB does not intercalate with DNA.  If this is so, how does it stain DNA?  Methylene blue is also a planar molecule that is just about the right size to intercalate with DNA.  If no evidence can be put forward to support MB's not intercalating with DNA, then it should be removed from the article.  — Preceding unsigned comment added by 152.79.176.240 (talk) 19:05, 21 September 2011 (UTC)
replies: text: Agreed. I was quite surprised when reading that. Intercalation is thought to be the preferred binding mode. Some references: doi:10.1111/j.1432-1033.1975.tb04137.x, doi:10.1002/bip.360210904, doi:10.1007/s10812-013-9811-7, doi:10.1002/bip.360350502, doi:10.1021/ja992966k, doi:10.1016/j.jphotobiol.2004.03.005, doi:10.1021/bi500068z - Falke000333 (talk) 08:10, 30 May 2017 (UTC)
thread_title:  Interaction with DNA and RNA? 

message: So I added a television show reference and it was deleted two times with the remark that WP does not have this kind of info. But the section is here already. Copied here is what it looked like before the untold stories of the ER info. was taken off. Anyone want to discuss this please?
(section blanked in bold)In popular culture
In the 1946 film noir, Decoy, the chemical is portrayed in an entirely different manner - as having resuscitative qualities – in that it is used successfully to bring a criminal back to life after execution by hydrocyanic gas.[48][49]
The tactic of using methylene blue to monitor medication compliance has been noted by authors such as Kurt Vonnegut in the 1968 story "Welcome to the Monkey House".
A 1982 episode of M*A*S*H, "Sons and Bowlers," showed Major Winchester using a dose of methylene blue to take down a rival camp's bowling champion—who had been a high-ranked professional bowler in civilian life—during a contest. The champ panics when his urine turns blue, and listens to Winchester's advice to refrain from all exercise – including bowling, which allows the 4077th to win.
The television show Untold Stories of the ER documented a prank using the chemical, in the episode, Frat Boy Blues.[50] In this story there was a full recovery from the prank, but for certain people the substance could be fatal.TeeVeeed (talk) 13:37, 10 June 2013 (UTC)
replies: text: So the last ref. is deleted twice by another editor. At the risk of edit-warring I am not re-un-doing, but in my opinion if there is a popular culture section, and there is further information, then why not add it?TeeVeeed (talk) 13:39, 10 June 2013 (UTC)
replies: text: None of these listings are worth including in the article.  They are all just trivia.  If methylene blue is central to an important work of literature, it may be worth mentioning, but these are all passing references (being noted in a story, a mention in a single episode or a TV series, etc.)  I particularly object to the Decoy reference which describes something entirely different than methylene blue (entirely fictional properties) which just happens to share a name with it.  -- Ed (Edgar181) 14:17, 10 June 2013 (UTC)
replies: text: I also dont think that TV shows are notable enough for inclusion in this article.  US TV shows, New Zealand TV shows, Burmese TV shows, or any TV shows for that matter.  It is cute information and I respect the motivation for including that information, but I think that the inclusion is misguided.  Trivia detracts from the encyclopedic tone (IMHO) and distracts from core information of those seeking knowledge of this compound.  According to Chemical Abstracts, 21503 technical articles have been written on methylene blue.  We cite a tiny fraction of these articles, why would a US TV show trump some technical article discussing discovery, uses, applications, environmental effects?  Seems like WP:UNDUE. --Smokefoot (talk) 17:22, 10 June 2013 (UTC)

text: As others have mentioned, this sort of random trivia does not belong in encyclopedia articles.  The sources for it were primary sources.  If you can identify secondary sources covering the phenomenon of methylene blue in TV shows like this, great, then it might be worthwhile to have these mentions, but without a secondary source to support, they're just trivial mentions and should not be in the article.  Zad68 19:17, 10 June 2013 (UTC)
replies: text: For an example of why this should be included, on the day that Untold Stories of the ER aired the repeat episode, "Frat Boy Blues", the article saw a spike of about 800 page views compared to the day before. Personally, I do not know exactly why someone would be interested, (wanting info. about the substance, or about the television show), and that really isn't my concern. But by "keeping"-cultural, media references, WP is enhanced by the preservation of these edits because it is easier for the users and readers to find whatever it was they were looking for. Q:What was the substance in that episode of Untold Stories of the ER? (Or, M*A*S*H...)A:Methylene Blue, or Q:What was that television show where they used Methylene Blue? A:...I'm not exactly sure if Untold Stories of the ER is fact or fiction, since in the episode they featured news cameras, supposedly documenting the "incident". A secondary source for that particular edit could be something else altogether, such-as "In the News".TeeVeeed (talk) 19:48, 10 June 2013 (UTC)
replies: text: I don't think the argument you're describing is based in Wikipedia content policy, and if it is I'd like to know which one.  Secondary sources are required to establish how noteworthy something like this is.  Otherwise we end up with this problem. Zad68 19:56, 10 June 2013 (UTC)
replies: text: I don't have a problem with secondary sources, I was asking if that could change the category to "news" for one item. In my opinion, the blanked content is "encyclopaedic Encyclopedia" (copied) "...a type of reference work – a compendium holding a summary of information from either all branches of knowledge or a particular branch of knowledge...." as opposed to a Dictionary which would have the more limited type of information that seems to be wanted here. TeeVeeed (talk) 20:26, 10 June 2013 (UTC)

text: I don't think there is any evidence to say that a TV show airing is responsible for a change in page view statistics.  But even if it were true that people are coming to this page because methylene blue was mentioned on some TV show episode, how is it helpful to them to include in the article a comment that methylene blue was mentioned in that TV episode?  ChemNerd (talk) 20:05, 10 June 2013 (UTC)
replies: text: A;To help someone find the article(s) in the first place based-on a presumable search.TeeVeeed (talk) 20:26, 10 June 2013 (UTC)

text: The compound was not just "mentioned" in the examples that were blanked. It was a critical part of the plot in each instance. In the literary reference, Welcome to the Monkey House, I would say even more-so, because although M-blue was referred-to, it was never mentioned by name in the story. If the purpose of WP is to provide encyclopedic information, it would qualify based on that alone. Also, in the film Decoy-the author is on record as stating that he used the compound in his story because of the antidote properties that he inferred due to cyanide and/or carbon monoxide gas from a gas chamber execution.So even-though it would be unlikely, there is a relation to the material.The Untold Stories of the ER, episode was the season premier episode and received more media coverage than usual because of that. That segment of the episode was used for the title. Also Untold Stories of the ER is a "docu-drama", which is that it is re-enactions of "real events". The M*A*S*H episode used it to advance the plot substantially, no "trivia" in any of this.
I'm willing to move all of this with a link to "See Also"-"Methylene Blue Cultural References", or whatever better heading that anyone can suggest. There just wasn't that much extra info. that i thought that it warranted it's own page, but better that than the blanking in my opinion. TeeVeeed (talk) 22:24, 10 June 2013 (UTC)

text: Agreed... at this point, TeeVeeed/Housewifehader is the only one still supporting this mention without any clear backing in content policy; everyone else involved here is bringing up concerns backed by Wikipedia content policies and guidelines including WP:UNDUE (especially due to the lack of secondary sources) and WP:CHEMMOS, and the concerns raised at WP:POPCULTURE.  Consensus is clearly heading against inclusion, but this RFC has only been open one day. Zad68 16:37, 11 June 2013 (UTC)

text: Well I invoke my silent supporters too....  And secondly, if page view count is the criterion for inclusion, more creative ways exist to attract views - dont get me going!!!  No: the criterion for inclusion is relevance to what readers are likely to seek to learn about methylene blue, it is a chemical compound with wide applicability (as I said, >21000 technical citations).  
*We all experience the pleasure of adding content.  But articles do not exist as vehicles to make editors feel good, they exist to address readers seeking information on methylene blue.  
*TV shows and novels probably do not present a credible chemical information.  Chemical compounds for stories are selected for their "buzz-effect" (do the chemical names sound scary, hi-tech, intellectuallizing, etc).  
*Editors of technical articles are careful about maintaining a non-national perspective, whereas this trivia tends to be US-oriented.  A national culture slant de-objectifies articles IMHO.--Smokefoot (talk) 17:50, 12 June 2013 (UTC)

text: I'm sorry, but you can't simply include supporters who aren't bothering to come share their views. You can use statistics to try to prove your point, but it's a fallacy to assume that everyone who learned of Methylene Blue through one of these TV episodes believes that the TV show should be mentioned in the article. Besides, Wikipedia works by consensus, not by majority. You can count random people all you want, but without commenting here, they do not add to the consensus. The whole point of an RFC is to get comments from folks who are otherwise disinterested parties (like myself), and if there's clear consensus one way after an RFC, it's a clear indication of what Wikipedia editors, as a group, think is the best direction. Arathald (talk) 09:20, 15 June 2013 (UTC)
thread_title:  In Popular Culture Section Blanked

message: Hello fellow Wikipedians,
I have just added archive links to  on Methylene blue. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Attempted to fix sourcing for http://archives.chicagotribune.com/2008/jul/30/health/chi-alzheimers-wedjul30
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—cyberbot IITalk to my owner:Online 03:39, 28 February 2016 (UTC)
thread_title:  External links modified 

message: I suggest using chembox, so that hazard and other chemical properties can be added. Punchalee.mon (talk) 15:42, 9 March 2016 (UTC)
replies: text: It is on the WHOs essential medicines list. Therefore a drugbox is good aswell. Doc James (talk · contribs · email) 23:30, 13 March 2016 (UTC)
thread_title:  Using Chembox instead of Drugbox 

message: According to Chemical Abstracts, methylene blue has been discussed in 45,333 publications and reports, 329 reviews have been written since the year 2000.--Smokefoot (talk) 16:33, 7 April 2018 (UTC)
thread_title: Citation report