Talk:Pyruvate dehydrogenase complex

message: It would probably be better if we didn't merge in unrelated articles like the reviewer suggested.  —Preceding unsigned comment added by 71.195.51.123 (talk) 19:46, 2 December 2007 (UTC)
thread_title: Untitled

message: In the article, it is stated that "pyruvate cannot diffuse passively because it carries a negative charge".  In the preceding sentence, the article then offers, without further clarification, that pyruvate transport is "active" and "requires energy".  I don't know the veracity of the fragment regarding its transport being active, although pyruvate is negatively charged.  What I'm not sure about is if the editor was fallaciously drawing a connection between the two clauses - just because passive diffusion is impossible does NOT mean active transport, requiring energy, is the only alternative.  Pyruvate could also be facilitated in its transport.  On the other hand, if pyruvate is moving against its concentration, or an electrical, gradient, its transport would indeed need energy.  In summary, the section on pyruvate's transport needs review by someone who knows whether it is active or not, and the details of its transport regardless.  - DrLight11  —Preceding unsigned comment added by 70.179.126.6 (talk) 02:50, 13 September 2010 (UTC)
replies: text: If it helps I remember reading somewhere about the net ATP gain of glucose metabolism, that the transport requires ATP. Sorry no source, maybe I will double check later when I have time.158.132.137.233 (talk) 06:11, 17 April 2014 (UTC)
thread_title:  Pyruvate transport 

message: The part about regulation mentions starvation causes LDC inhibition, thus reducing the amount of pyruvate converted to Acetyl-CoA. It is not explicitly mentioned if pyruvate production(glycolysis) is also lowered, though if not then pyruvate would build up? It is also implied that after LDC inhibition fat metabolism will be promoted rather than fermentation, I guess because increased fermentation would decrease glucose stores faster. I think the regulation pathways could be better defined, as it is not clear how inhibition of LDC is substituted by other energy synthesis pathways (or apoptosis).158.132.137.233 (talk) 06:36, 17 April 2014 (UTC)
replies: text: Of I meant PDC instead of LDC, of course. Mistake.158.132.137.233 (talk) 08:20, 17 April 2014 (UTC)
thread_title:  Unclear link between LDC inhibition and lower glucose metabolism 

message: Substituted at 03:35, 30 April 2016 (UTC)
thread_title: Assessment comment

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