Talk:2-Butoxyethanol

message: Is kt/a = kilotons/annum (kilotons/year) ?  Also, are those metric tons or 2000 lbs tons ? 
H Padleckas 13:13, 20 July 2005 (UTC)
thread_title: Is '''kt/a''' = kilotons/annum (kilotons/year) ?  Also, are those metric tons or 2000 lbs tons ? 

message: The text in the section "Medical effects" comes directly word-for-word from the page listed as the first external link . This text should be rewritten in order that it might not be an exact copy. Using the information in that article is acceptable, but just copying it is not (see Wikipedia:Copyrights). I am not sure if somehow Wikipedia has permission to reproduce that page and if so, please reply here; otherwise, rewrite that section. If there is no response here and no change to the article after 1 week, I will delete that section. KHenriksson 07:00, 9 July 2006 (UTC)
thread_title:  Text Copied Verbatim from ToxFAQs 

message: Just a note to all that copying text directly from http://www.atsdr.cdc.gov/tfacts118.html or any other external website without permission constitutes copyright violation. I will continue to delete any copyrighted information unless it is rewritten and cited.VandalCruncher (talk) 15:26, 20 December 2007 (UTC)
thread_title: Copyrighted Text

message: I delinked the following link to ethylene glycol because I think it gives people the impression that this compound is identical to ethylene glycol:
OtherNames = butyl cellosolvebutyl glycolethylene glycol monobutyl ether 
--Rifleman 82 (talk) 05:14, 31 December 2007 (UTC)
thread_title:  Delinked 

message: I just came across the name referring to both compounds on Google, I had a WFT moment. Ok, I'll run with this...hmm.. I had to call poison control cause a buddy did something stupid, they listed that compound with all the other ethylene.  If I come across any ref that clarify the issue I'll make the changes and post the 411 here.Lyta79 (talk) 07:38, 31 December 2007 (UTC)
thread_title:  RFC RE: 2-Butoxyethanol vs. Ethylene_glycol 

message: During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!
* http://ia331209.us.archive.org/0/items/AirFoamHdMaterialDataSafetySheetmsds/
** In 2-Butoxyethanol on 2011-05-25 06:55:18, Socket Error: 'getaddrinfo failed'
** In 2-Butoxyethanol on 2011-06-10 04:43:16, Socket Error: 'getaddrinfo failed'
--JeffGBot (talk) 04:43, 10 June 2011 (UTC)
thread_title:  Dead link 

message: During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!
* http://www.eastman.com/Product_Information/ProductHome.asp?Product=71000130
** In 2-Butoxyethanol on 2011-05-25 06:55:21, 404 NOT FOUND
** In 2-Butoxyethanol on 2011-06-10 04:43:18, 404 NOT FOUND
--JeffGBot (talk) 04:43, 10 June 2011 (UTC)
thread_title:  Dead link 2 

message: "Butyl Cellosolve" is much better know and more searched than the chemical name.  Findable. 
"Butyl Celosolve" is a common misspelling, which should also redirect here.
*.  I have created redirects for those terms.  -- Ed (Edgar181) 12:39, 26 June 2012 (UTC)
thread_title: Butyl Cellosolve ubiquitous trade name, should redirect to this article 

message: Please refer to page 7 of this attachment of the congressional report on "CHEMICALS USED IN HYDRAULIC FRACTURING". http://democrats.energycommerce.house.gov/sites/default/files/documents/Hydraulic-Fracturing-Chemicals-2011-4-18.pdf  — Preceding unsigned comment added by 24.187.208.114 (talk) 10:31, 25 September 2013 (UTC)
thread_title:  2-Butoxyethanol use in Hydraulic Fracturing 

message: For the 2-butoxyethanol page, we would like to begin by expanding on production and uses. In particular, we would like to include more information on the involvement on 2-butoxyethanol in fracking.  We would like to clarify the conflicting reports on the carcinogenic properties of 2-butoxyethanol, in addition to supplying more general health information.  We would like to expand on the effects that it has on humans and other animals.  The environment effects section is currently minimal, so we would like to expand on how it moves through the environment.  In particular, its solubility in water, air, and soil and how that affects where it exists.  Comparison of different measurements of 2-butoxyethanol in the environment will also be included.  Our plan is to keep the general format and content of the article, and to simply expand upon relevant information. Blairwal (talk) 20:21, 17 February 2014 (UTC)
thread_title: Plan for updating article

message: Intro:
* I don’t really get a sense of what the chemical does until the last sentence of the intro, so add that it’s a solvent in the first sentence. Maybe also mention some of the main things it’s used in, which would definitely generate interest for the rest of the article. I would also add something about it being a carcinogen
Production:
* change “the main routes” to something like “to yield/produce 2-butoxyethanol”…or maybe switch sentence to make butanol and ethylene oxide the subjects. 
Uses:
* I like the background on glycol ethers. Is 2-buto in the E series or P series? 
* It seems like the second paragraph that begins with “In 2006” would fit better under the production heading
* I’m unsure as to what an indirect food additive is…either wikilink or explain this 
* “When liquid is pumped into the well, 2-Butoxyethanol is used to stabilize the fracturing fluids that are being pumped under extreme pressure by lowering the surface tension and to facilitate release of the oil by preventing congealing” this sentence is too long and complex, and needs verb agreement between “lowering” and “to facilitate” 
* It might be useful to split this up into subheadings by industry
Safety:
*you should combine “environmental fate” with “disposal and degradation,” as they convey the same message
*I would put regulation after animal studies, because human exposure and animal studies are more logically linked
Intro:
* This paragraph seems contradictory in saying that it’s not a carcinogen in humans and is not reported as such, but should be handled with extreme caution
* Most of this info would fit better under animal studies. Perhaps the first paragraph should just convey that it is a possible carcinogen, and has been tested in rats and humans.
Human Exposure:
* the phrase “odor threshold” is confusing. Does this mean that if you can smell it, you are definitely above the threshold for exposure?
regulation in Canada:
*“these products are not required..” these doesn’t have an antecedent 
* what point of dilution is needed to be legally unreported?
* “The safety of the products as normally used” – confusing. Does this mean these groups defend its use, and oppose the concerns of the CEPA?
Animal Studies:
* I don’t know what Fischer 344 rats are. Is this detail significant in the study?
*This is a really clear paragraph that flows well
Overall:
*make sure to use either 2-butoxyethanol or simply butoxyethanol the entire time, because the switching in the middle of the article gave me the impression you were talking about different molecules
*I am still left with some questions: what specific level are you using to designate high, moderate, and low levels? As a consumer using many of these products, is the level of exposure on a daily basis possibly damaging? 
*consolidate your references by using < ref name= “author”/ >  to eliminate redundancies
* A really well written article! The writing was very clear and it was packed with information. Great job! My corrections were knit-picky and a matter of opinion, so change things as you think…you’re the experts. ☺
Dehringb (talk) 21:34, 2 April 2014 (UTC)
thread_title: Peer Reviews

message: This article contains a lot of information about what 2-Butoxyethanol is used in and regulations put in place to limit the amount of the chemical in the environment.  It is well organized but it feels like it's missing some information.  The introduction doesn't really explain what the chemical does, just what it is.  In order to have a better idea about how it is harmful to humans/the environment there might want to be some mention of what the role 2-Butoxyethanol plays in the products in which it is found.  There is also not a lot of information about the effects that it has on humans.  While it is difficult to find studies about human exposure to chemicals, it would be interesting to hear if there is any crossover between what happens to animals and humans when they are exposed to the chemical.  It is clear that there are high levels of exposure found in industrial settings and that exposure does cause respiratory issues among other things, but how does the chemical cause those problems? 
Aukere (talk) 00:49, 3 February 2015 (UTC)
thread_title: Peer Review 3

message: Laboratory tests by the U. S. National Toxicology Program have shown that only sustained exposure to high concentrations (100-500 ppm) of 2-butoxyethanol can cause adrenal tumors in animals. Butoxyethanol has a low acute toxicity, with  of 2.5 g/kg in rats.Siegfried Rebsdat, Dieter Mayer "Ethylene Oxide" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005..   American Conference of Governmental Industrial Hygienists (ACGIH) reports that 2-butoxyethanol is carcinogenic in animals. However, due to the fact that cancer was primarily found in the forestomach which is absent in humans, these rodent tests may not translate directly to carcinogenicity in human beings.   OSHA does not regulate 2-butoxyethanol as a carcinogen. 
===Disposal and degradation===
2-Butoxyethanol can be eliminated by incineration. While it usually decomposes in the presence of air within a few days when reacting with oxygen radicals Hullar, T.; Anastasio, C. Yields of hydrogen peroxide from the reaction of hydroxyl radical with organic compounds in solution and ice. Atmospheric Chemistry and Physics, 11, 7209. , disposal occurs faster in the presence of semiconductor particles.  As there is no evidence to suggest it as a major environmental contaminant, nor is it known to bio-accumulate, it seems to be fairly manageable. Agency for Toxic Substances and Disease Registry ToxFAQs
===Human exposure===
Moderate respiratory exposure to 2-butoxyethanol often results in irritation of mucous membranes of the eyes, nose and throat. Heavy exposure via respiratory, dermal or oral routes can lead to hypotension, metabolic acidosis, hemolysis, pulmonary edema and coma.  The current ACGIH threshold limit value (TLV) for worker exposure is 20 ppm in the industrial atmosphere, which is well above the odor threshold of 0.4 ppm. 2-Butoxyethanol is metabolized in animals by the enzyme alcohol dehydrogenase. Blood or urine concentrations of 2-butoxyethanol or its major toxic metabolite, 2-butoxyacetic acid, can be detected using chromatographic techniques to monitor worker exposure and diagnose levels of toxicity in hospitalized patients. A biological exposure index of 200 mg 2-butoxyacetic acid per gram creatinine has been established in an end-of-shift urine specimen for exposed U.S. employees.2009 TLVs and BEIs, American Conference of Industrial Hygienists, Cincinnati, Ohio, 2009, p.101. 2-Butoxyethanol and its metabolites fall to undetectable levels in urine after about 30 hours.
===Regulation in Canada===
After considerable scrutiny, the Environment and Health Canada recommended that 2-Butoxyethanol be added to Schedule 1 of the Canadian Environmental Protection Act (CEPA).   These products are not required to list it on the label when diluted to a certain point. The safety of the products as normally used is defended by the American Chemistry Council and the Soap and Detergent Association, industry trade groups.
===Regulation in U.S.===
U.S. Employers are required to inform employees working with 2-Butoxyethanol.
Butoxyethanol is listed in the U.S. state of California as a hazardous substance, though it was removed from the U.S. Environmental Protection Agency's list of hazardous air pollutants in 1994.
===Animal studies===
Potentially harmful effects have been observed in animals exposed to high levels of 2-butoxyethanol. One study exposing pregnant Fischer 344 rats and New Zealand white rabbits to varying doses of 2-butoxyethanol revealed lasting developmental effects  A statistically significant increases in skeletal defects were detected in litters treated with  100 ppm (483 mg/m3) and 200 ppm (966 mg/m3).  Additionally, 2-butoxyethanol was associated with a significant decrease in maternal body weight, uterine weight, and number of total implants.<ref>Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf></ref>
Neurological effects were identified in one study involving 344 rats tested with 2-butoxyethanol at concentrations of 523 ppm and 867 ppm.  Both female and male rats experienced decreased coordination after exposure. Similarly male rabbits in another study exhibited a loss of coordination and equilibrium when given a dose of 400 ppm 2-butoxyethanol for 2 days.United States of America. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate. By Olivia Harris, Sharon Wilbur, Julia George, and Carol Eisenmann. Atlanta: n.p., 1998. Agency for Toxic Substances and Disease Registry. Web. <http://www.atsdr.cdc.gov/toxprofiles/tp118.pdf>
Both F344/N rats and B63F1 mice showed negative effects after 2-butoxyethanol in their drinking water.  The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day.  Decreased body weight and water consumption were seen for both species. Rats had reduced red blood cell counts and thymus weights, as well as lesions in the liver, spleen, and bone marrow.Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf>.
Some modifications that I made throughout the page include:
•	Replacing sentences that begin with “It”
•	Combining short sentences
•	Eliminating repetition
•	Keep in mind to use an active voice, not a passive voice. Clearer and to the point in some cases. Passive voice with controversial points.
Uses:
•	18% for metals production or a metal cleaner?
•	Facilities for sterilizing and cleaning=sterilizing and cleaning facilities or = used to sterilize and clean at facilities?
Safety
•	Observed “mechanism” (right word?/slightly confusing)
•	OSHA does not regulate 2-butoxyethanol as a carcinogen.[citation needed]
Disposal
•	Semiconductor particles-link
Human Exposure
•	Odor threshold of 0.4ppm, what is that?
Regulation in Canada
•	What is schedule 1?
•	What list of products are you referring to?
•	Are butoxyethanol and 2-Butoxyethanol the same thing?
Animal Studies
•	Study by Ty et al. or Dodd et al seems very strange, would not make sense to the normal reader. Who is he/are they?
•	Some of the smaller paragraphs have a few sentences with one reference at the end of the paragraph. Was that one reference a citation for 
each sentence, if so, make sure that is the proper format as I was not sure
•	What exactly is meant by range of exposure? Amount of chemical retained afterwards?
Environmental Fate: REPEAT of information from disposal section/not needed
•	butoxyethanol degrades in air within a few days or weeks.  It has not been identified as a major environmental contaminant, nor is it known to bio-accumulate.- wikilink with first reference in article as this is the second time and do not need to create link if already done so, even if a specific word or phrase is mentioned again
I read through your article and found that it was well done. I made edits throughout in this version where I thought that they could prove helpful although you are free to take or leave any input here. I tried to be as constructive as possible in my criticism. I would find another way to mention the example studies instead of by author as the average reader would care less about what some random scientist says.  If he or she has a specific title, then mention it; if not, then make it more general: “A study or one study.” That draws more attention to the study rather than unknown researchers. There was a good overall flow and it was relatively clear although there were some parts where I was a littler uncertain as to what was being referenced.  The citations seem to be in check, aside from one or two spots where it was shown to be needed already.  (Wess, J.; Ahlers, H.; Dobson, S. (1998). Concise International Chemical Assessment Document 10: 2-Butoxyethanol. Geneva: World Health Organization.) was cited 2 or 3 times in the reference section. Find a way so that your multiple in-text citations for the same source refer to the same one in your reference list. This article appears to be pretty neutral as far as just stating the facts but the end seems to favor the side that it is harmful. Show evidence from both sides of the studies or at least take a more passive stance when revealing conclusions. You have a lot of great headings, but look to make your leading sentence more interesting.  It seemed a little repetitive at first and it could have been worded better. Add some more general information Looks to have a fair amount of information added though, so good work! I especially like the USES section. Maybe work to expand the global opinions on this chemical, since only Canada and the US are mentioned. Make it more international. Overall, again well done and I hope some of this was helpful. 
WlfSprtd23--WlfSprtd23 (talk) 11:02, 11 April 2014 (UTC)
replies: text: Dear WlfSprtd23: What qualifies you to state "I read through your article and found that it was well done." ? Do you publish in this area?--Smokefoot (talk) 14:30, 11 April 2014 (UTC)
thread_title: Safety

message: Potentially harmful effects have been observed in animals exposed to high levels of 2-butoxyethanol. One study exposing pregnant Fischer 344 rats and New Zealand white rabbits to varying doses of 2-butoxyethanol revealed lasting developmental effects  A statistically significant increases in skeletal defects were detected in litters treated with  100 ppm (483 mg/m3) and 200 ppm (966 mg/m3).  Additionally, 2-butoxyethanol was associated with a significant decrease in maternal body weight, uterine weight, and number of total implants.<ref>Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf></ref>
Neurological effects were identified in one study involving 344 rats tested with 2-butoxyethanol at concentrations of 523 ppm and 867 ppm.  Both female and male rats experienced decreased coordination after exposure. Similarly male rabbits in another study exhibited a loss of coordination and equilibrium when given a dose of 400 ppm 2-butoxyethanol for 2 days.United States of America. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate. By Olivia Harris, Sharon Wilbur, Julia George, and Carol Eisenmann. Atlanta: n.p., 1998. Agency for Toxic Substances and Disease Registry. Web. <http://www.atsdr.cdc.gov/toxprofiles/tp118.pdf>
Both F344/N rats and B63F1 mice showed negative effects after 2-butoxyethanol in their drinking water.  The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day.  Decreased body weight and water consumption were seen for both species. Rats had reduced red blood cell counts and thymus weights, as well as lesions in the liver, spleen, and bone marrow.Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf>.
Some modifications that I made throughout the page include:
•	Replacing sentences that begin with “It”
•	Combining short sentences
•	Eliminating repetition
•	Keep in mind to use an active voice, not a passive voice. Clearer and to the point in some cases. Passive voice with controversial points.
Uses:
•	18% for metals production or a metal cleaner?
•	Facilities for sterilizing and cleaning=sterilizing and cleaning facilities or = used to sterilize and clean at facilities?
Safety
•	Observed “mechanism” (right word?/slightly confusing)
•	OSHA does not regulate 2-butoxyethanol as a carcinogen.[citation needed]
Disposal
•	Semiconductor particles-link
Human Exposure
•	Odor threshold of 0.4ppm, what is that?
Regulation in Canada
•	What is schedule 1?
•	What list of products are you referring to?
•	Are butoxyethanol and 2-Butoxyethanol the same thing?
Animal Studies
•	Study by Ty et al. or Dodd et al seems very strange, would not make sense to the normal reader. Who is he/are they?
•	Some of the smaller paragraphs have a few sentences with one reference at the end of the paragraph. Was that one reference a citation for 
each sentence, if so, make sure that is the proper format as I was not sure
•	What exactly is meant by range of exposure? Amount of chemical retained afterwards?
Environmental Fate: REPEAT of information from disposal section/not needed
•	butoxyethanol degrades in air within a few days or weeks.  It has not been identified as a major environmental contaminant, nor is it known to bio-accumulate.- wikilink with first reference in article as this is the second time and do not need to create link if already done so, even if a specific word or phrase is mentioned again
I read through your article and found that it was well done. I made edits throughout in this version where I thought that they could prove helpful although you are free to take or leave any input here. I tried to be as constructive as possible in my criticism. I would find another way to mention the example studies instead of by author as the average reader would care less about what some random scientist says.  If he or she has a specific title, then mention it; if not, then make it more general: “A study or one study.” That draws more attention to the study rather than unknown researchers. There was a good overall flow and it was relatively clear although there were some parts where I was a littler uncertain as to what was being referenced.  The citations seem to be in check, aside from one or two spots where it was shown to be needed already.  (Wess, J.; Ahlers, H.; Dobson, S. (1998). Concise International Chemical Assessment Document 10: 2-Butoxyethanol. Geneva: World Health Organization.) was cited 2 or 3 times in the reference section. Find a way so that your multiple in-text citations for the same source refer to the same one in your reference list. This article appears to be pretty neutral as far as just stating the facts but the end seems to favor the side that it is harmful. Show evidence from both sides of the studies or at least take a more passive stance when revealing conclusions. You have a lot of great headings, but look to make your leading sentence more interesting.  It seemed a little repetitive at first and it could have been worded better. Add some more general information Looks to have a fair amount of information added though, so good work! I especially like the USES section. Maybe work to expand the global opinions on this chemical, since only Canada and the US are mentioned. Make it more international. Overall, again well done and I hope some of this was helpful. 
WlfSprtd23--WlfSprtd23 (talk) 11:02, 11 April 2014 (UTC)
replies: text: Dear WlfSprtd23: What qualifies you to state "I read through your article and found that it was well done." ? Do you publish in this area?--Smokefoot (talk) 14:30, 11 April 2014 (UTC)
thread_title: Animal studies

message: Hello, I am a student enrolled in course Environmental Disruptors/Development at BC.
As an assignment, we are going around leaving some comments in articles that were worked on in previous courses.
◌For Human Exposure section
I found some related information that could have been included and expand the section.
That most people start to smell the chemical in air at 0.10-0.40 ppm which is 500 times lower than the present standard for worker exposure. http://www.atsdr.cdc.gov/phs/phs.asp?id=345&tid=61
Including that household cleaners like varnishes, lacquers, latex paints as common source of the chemical in this section might help the readers grasp the info that they need quicker. But I am aware that you included such information up on "commercial uses" section.
More information on how it enters and leaves one's body might be useful. That the exposure is less likely through eating or drinking but more from breathing in air (through the lung)-also the fact that wearing protective clothing decreases the entrance through skin. The reaminder of butoxyethanol enters the bloodstream possibly causing being converted into metabolites in the liver. If you want more information visit http://www.atsdr.cdc.gov/phs/phs.asp?id=345&tid=61
Thank you for all your work!
Jukaredaa (talk) 06:24, 3 February 2015 (UTC)
replies: text: Please use good sources: published reviews and textbooks. Avoid Google searching! You are welcome to ask for advice!  This article is a mature one, and it would be surprising if a nonexpert could make major contributions.  Good luck.--Smokefoot (talk) 14:43, 3 February 2015 (UTC)
thread_title: =classmate comment February 2015=

message: The page currently lists the GHS classification of this material as:
H227, H302, H311, H315, H319, H330, H336, H361, H370, H372
This does match the description of the text which claims a "Low acute toxicity" and also does not match the harmonised classification or the ECHA dossier for the material, which classifies it as:
H302, H312, H315, H319, H332, Signal word: WARNING (GHS07)
The classification that is currently used in the page is similar to 2-methoxyethanol and 2-ethoxyethanol, it makes sense that either one of these classifications was used in error or the SDS used to derive the given classification was for a product containing material of a more severe classification.
If people agree with this assessment then I will happily make the modifications to the page.  — Preceding unsigned comment added by 151.249.75.66 (talk) 10:24, 29 August 2017 (UTC)
thread_title:  Hazard classification