Talk:Hepatocellular carcinoma

message: In hepatocellular carcinoma , there is high level of serum copper and copper to zinc ratio as the serum zinc level is low.Is this interesting to measure the serum copper and zinc level?
:Firstly, what is your source. Secondly, what would the cause be. Thirdly, are you now going to give penicillamine or zinc if there is otherwise no clinical need (e.g. neurological symptoms) to do so? JFW | T@lk 07:21, 7 August 2007 (UTC)
thread_title: Copper

message: Since liver cancer is not synonym for hepatocellular carcinoma, I turned liver cancer, which was previously a redirect to here, to a disambiguation page. --Steven Fruitsmaak 12:50, 22 May 2006 (UTC)
thread_title: Liver cancer

message: >(an alternative name may be hepatoma)
This was originally mentioned after the name. However, hepatomas are generally benign and harmless, which cannot be said about HCC Jfdwolff 00:05, 27 Feb 2004 (UTC)
replies: text: So hepatoma should be a disambiguation. JFW | T@lk 21:00, 3 Jan 2005 (UTC)

text: Eh? With respect, I think that you made a mistake. Hepatoma = hepatocellular carcinoma. Axl 12:14, 5 Jan 2005 (UTC)

text: I call them benign liver tumours/cysts/adenomas. Axl 09:54, 6 Jan 2005 (UTC)

text: Hehe! :-) It is exactly this sort of confusion that caused the word (hepatoma) to fall into disuse. It doesn't comply with the general rule that solid epithelium-derived cancers should be designated 'carcinoma'. Axl 21:28, 6 Jan 2005 (UTC)
thread_title: Hepatoma

message: Is Aspergillus responsible for a "unique" type of HCC ? I wasn't aware of there being a big difference between the two forms, and also leaves us with the problem of what to do with those who have both Hep B and Aflatoxin (e.g. in West Africa) MattW 12:35, 26 July, 2005
:Aflatoxin is a carcinogen; as the liver filters out most toxins, it has a habit of building up in the liver. As it still affects hepatocytes, I don't think there should be much of a difference between a HCC caused by aflatoxin, Hep B, alcohol or simply bad luck.Serrin 11:06, 10 May 2007 (UTC)
thread_title: Some Questions

message: Does anyone object against this article (Franca AV, Elias Junior J, Lima BL, Martinelli AL, Carrilho FJ. Diagnosis, staging and treatment of hepatocellular carcinoma. Braz J Med Biol Res 2004;37:1689-705. ) as a background review? JFW | T@lk 15:50, 16 May 2005 (UTC)
thread_title: Background review

message: I found a lot of content removed in this edit, by an anon with one edit. I've restored the lost content, but there have been some minor changes made since then that are now lost. I think this is the proper action, but if anyone disagrees, let me know. --Arcadian 01:51, 29 January 2006 (UTC)
thread_title: Restoration of content

message: Incidence in Europe and USA  JFW | T@lk 07:21, 7 August 2007 (UTC)
replies: text: MRI is the best for diagnosis:  JFW | T@lk 11:30, 19 October 2007 (UTC)
replies: text: Comparison of staging systems:  JFW | T@lk 01:00, 4 November 2007 (UTC)
thread_title: Epidemiology

message: Anybody who does not know that hepatoma is the same as hepatocellular carcinoma should NOT contribute to this article !!!81.244.197.160 (talk) 20:44, 28 March 2008 (UTC)
replies: text: Can you expand, I am a bit confused, I certainly don't know the difference and am a contributor to this article but we want a really good article so clarifying your comment would be really helpful. Thankis SqueakBox 20:47, 28 March 2008 (UTC)

text: This relates to my above message from 2004. At that time I had undergone most of my training in a country where the term "hepatoma" is not routinely used, and I therefore acted on the understanding that anything called "-oma" must be benign. I stand corrected. I'm unsure why 81.244.197.160 seems to be so upset with me about this. The user has no other edits, and I can't remember ruffling any feathers in that IP range. JFW | T@lk 11:21, 21 May 2008 (UTC)
thread_title: JfdWolff

message: Study that lacks solid conclusions (from abstract at least) about HCC in the USA. Risk is higher in particular ethnic groups, which probably reflects the fact that they have risk factors. 
 JFW | T@lk 11:21, 21 May 2008 (UTC)
thread_title: Epidemiology

message: Just curious, but why haven't epidermal growth factors been mentioned in this article? I recently read an article in JAMA (DOI 10.1001/jama.2007.65) of relationship between a single nucleotide polymorphism on the EGF gene and the risk for developing HCC in patients with cirrhosis. Another article (PMID 7862454) from 1995 determined that the overexpression of secreted EGF fusion protein led to the development of HCC in transgenic mice. I think this new research is worth mentioning in the "Future directions" section of the article. Nishkid64 (Make articles, not wikidrama) 20:46, 17 September 2008 (UTC)
thread_title:  Epidermal growth factors 

message: Needs extensive work to add inline references and reorganization to fulfill GA criteria.  The treatment section is currently just a bunch of bullet points.  Needs to be wikified.  No verification for the people who had this condition.  Could also do with a expanded classification section.--Doc James (talk · contribs · email) 03:20, 31 May 2009 (UTC)
thread_title: GA review

message: Considering that this page is likely to be read by patients and their families trying to understand hepatoma and how it can be treated, the section on treatment needs considerable work to update it and correct a number of errors. For example, the article states that cryosurgery is "a new technique" - when in fact it has existed for decades and has been widely used to treat hepatoma since the 1980s. In the case of hepatoma it is also associated with high-risk to patients from shock, which can arise as a result of hormone and enzyme cascades triggered by the therapy. On the other hand, radiofrequency ablation as a treatment for hepatoma is relatively new (in widepsread use less than 7 years) and considered favorable to cryosurgery as it is minimally invasive, less risky and easier to perform (negligible risk of harmful biochemical response). The discussion of TACE is also incorrect - it states that TACE is not suitable for treatment of large tumors >8cm; this figure should be revised to >15cm, as it is now commonly used and frequently succeeds for tumors up to that size, without concurrent PEI or other treatments.
Anyway, some update is certainly needed. Mudpuddles1418 (talk) 22:46, 23 June 2009 (UTC)
replies: text: Those points are still in the article - perhaps because we need RS for changes ? - Rod57 (talk) 13:23, 7 July 2017 (UTC)
thread_title: Treatment

message: i suggest merging hepatocellular carcinoma into the liver cancer article for two reasons:1 this article does not cite any refrences,needs updating,wikification,and cleanup.and 2 hcc is the main type of liver cancer.24.97.164.250 (talk) 16:47, 9 December 2009 (UTC)
replies: text: Liver tumor and Liver cancer should be merged, but Hepatocellular carcinoma should be kept separate. There are many other types of liver tumors. --Arcadian (talk) 12:04, 16 February 2010 (UTC)
replies: text: Hepatocellular carcinoma should be summarized in a section in liver cancer and I agree liver cancer and tumor should be merged.Doc James (talk · contribs · email) 14:20, 17 February 2010 (UTC)
thread_title:  merge into liver cancer. 

message: * Talk:Liver cancer#The disease and its dietary concern....--124.78.212.48 (talk) 08:18, 19 January 2010 (UTC)
thread_title:  The disease and its dietary concern...see... 

message: ==Society and culture==
=== Awareness ===
The Jade Ribbon Campaign is used for awareness of liver cancer and hepatitis B in the Pacific Islands, where such illnesses are more widespread than elsewhere.
===Famous people===
*Johannes Brahms famous late Romantic German composer. Died April 3, 1897 of liver cancer.
*Morihei Ueshiba founder of the Japanese martial art of aikido. Died in 1969 of hepatocellular carcinoma.
*John Coltrane Jazz musician. Died in 1967 from liver cancer.
*Jim Hutton Died in 1979 from liver cancer.
*Mickey Mantle Hall of Fame Baseball player with the New York Yankees.
*Chris LeDoux Country Music Hall of Fame legend, and former Pro Rodeo rider.
*Munetaka Higuchi Drummer for Japanese heavy metal band Loudness, died in 2008 of hepatocellular carcinoma.
*Mick Ronson British Rock'n'Roll guitarist who died in 1993 of hepatocellular carcinoma.
*Erich Honecker former leader of East Germany who died in 1994 in exile.
*Ray Charles famous recording soulful music artist, Rock And Roll Hall of Fame, died on June 10, 2004.
*Sun Yat-sen Father of the Nation in mainland China and in Taiwan
*Édith Piaf French singer and cultural icon who "is almost universally regarded as France's greatest popular singer.", died on 10 or 11 October 1963.
*Gregory Hines Professional dancer, film actor, and choreographer. Died in August 2003 of liver cancer.
*Dave Thomas Founder of Wendys, died in 2002 of liver cancer.
*Joan Finney Governor of Kansas (1991–1995) died of liver cancer in 2001
*Robin Gibb Musician, member of the Bee Gees. Died of liver cancer in 2012http://www.reuters.com/article/entertainment-us-robingibb-death-idUSBRE84J0CN20120521
Doc James (talk · contribs · email) 01:19, 23 December 2011 (UTC)
thread_title: Needs refs

message: *Johannes Brahms famous late Romantic German composer. Died April 3, 1897 of liver cancer.
*Morihei Ueshiba founder of the Japanese martial art of aikido. Died in 1969 of hepatocellular carcinoma.
*John Coltrane Jazz musician. Died in 1967 from liver cancer.
*Jim Hutton Died in 1979 from liver cancer.
*Mickey Mantle Hall of Fame Baseball player with the New York Yankees.
*Chris LeDoux Country Music Hall of Fame legend, and former Pro Rodeo rider.
*Munetaka Higuchi Drummer for Japanese heavy metal band Loudness, died in 2008 of hepatocellular carcinoma.
*Mick Ronson British Rock'n'Roll guitarist who died in 1993 of hepatocellular carcinoma.
*Erich Honecker former leader of East Germany who died in 1994 in exile.
*Ray Charles famous recording soulful music artist, Rock And Roll Hall of Fame, died on June 10, 2004.
*Sun Yat-sen Father of the Nation in mainland China and in Taiwan
*Édith Piaf French singer and cultural icon who "is almost universally regarded as France's greatest popular singer.", died on 10 or 11 October 1963.
*Gregory Hines Professional dancer, film actor, and choreographer. Died in August 2003 of liver cancer.
*Dave Thomas Founder of Wendys, died in 2002 of liver cancer.
*Joan Finney Governor of Kansas (1991–1995) died of liver cancer in 2001
*Robin Gibb Musician, member of the Bee Gees. Died of liver cancer in 2012http://www.reuters.com/article/entertainment-us-robingibb-death-idUSBRE84J0CN20120521</blockquote>
Doc James (talk · contribs · email) 01:19, 23 December 2011 (UTC)
thread_title: Famous people

message: In the Diagnosis section of the article it mentions that a biopsy to confirm the diagnosis is not required if certain imaging criteria are met. What are the criteria? Nonagonal Spider (talk) 06:24, 9 January 2012 (UTC)
thread_title:  Diagnosis 

message: Seminar doi:10.1016/S0140-6736(11)61347-0 JFW | T@lk 20:26, 29 April 2012 (UTC)
replies: text: Paywalled. Abstract doesn't promise much. Does it say anything worth putting in the WP article ? - Rod57 (talk) 13:29, 7 July 2017 (UTC)
thread_title:  Lancet 

message: Gut doi:10.1136/gutjnl-2014-307990 JFW | T@lk 14:20, 6 April 2015 (UTC)
replies: text: Current concepts of immune based treatments for patients with HCC: from basic science to novel treatment approaches Greten et al. - sadly paywalled : abstract says it's "... an overview for the rationale of immunotherapy in HCC, summarise ongoing studies and provide a perspective for immune based approaches in patients with HCC." - Could use in Research section ? - Rod57 (talk) 13:11, 7 July 2017 (UTC)
thread_title:  Immune-based therapies 

message: doi:10.7326/M14-2509 - MRI is most sensitive, CT/MRI are better than USS. JFW | T@lk 15:41, 19 May 2015 (UTC)
thread_title:  Imaging review 

message: Hello fellow Wikipedians,
I have just added archive links to  on Hepatocellular carcinoma.  my edit. ... I made the following changes:
*Added archive https://web.archive.org/20140325025254/http://online.wsj.com/article/PR-CO-20130508-915494.html to http://online.wsj.com/article/PR-CO-20130508-915494.html
   archive only shows Title - no content.
  
Cheers. —cyberbot IITalk to my owner:Online 13:46, 17 October 2015 (UTC)
thread_title:  External links modified 

message: doi:10.1053/j.gastro.2015.12.041 JFW | T@lk 10:16, 31 March 2016 (UTC)
replies: text: Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma Bruix et al. - Full text - Looks good. - Rod57 (talk) 13:16, 7 July 2017 (UTC)
thread_title:  Review 

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*Added archive https://web.archive.org/web/20130724080242/http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index5.html to http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index5.html
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thread_title:  External links modified 

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thread_title:  External links modified 

message: Metabolic syndrome and NASH [first mention] are also increasingly recognized as risk factors for HCC.
— MaxEnt 13:09, 22 September 2018 (UTC)
thread_title:  NASH unglossed in lead