lflage/wiki-talks huggingface dataset:
Talk:Second messenger system

message: Are the gases (NO and CO)really considered second messengers? It seems that in order for something to be a second messenger there needs to be a first messenger. --Dbrouse (talk) 06:33, 26 July 2008 (UTC)
thread_title: Untitled

message: Hi all,
Many of the references for this page are not found anymore. Providing better references may also improve the content via expanding on the provided examples.
The following articles and reviews seem to encompass a majority of the provided information and much more:
* 
The above reference gives more information about the cAMP pathway that is used as an example. It is also a source that is published as an article, which "reviews" the pathway in general.
I would also like to talk about the epinephrine pathway. It is a good pathway that helps people understand how and where secondary messengers play a role, and it utilizes the stated examples.
Here is a paper that talks about the Inositol signaling pathway and how the other second messengers such as Ca2+ and DAG play a role, along with the end goal.
* 
And lastly, the last example which involves the Histimine Pathway, the following paper helps understand the contribution of the second messenger.
* 
The papers also provide descriptions of how each secondary messenger plays its role and provides a better understanding of a second messenger in general.
Now, I understand this may be stepping foot into other wiki pages, so I will try my best to cite other pages if need be, along with utilizing the information provided in these reviews and articles.
Please let me know what you think about the idea, the papers I plan on utilizing, and any ideas that come to mind that can support this endeavor. Ayun2 (talk) 22:37, 10 October 2018 (UTC)
replies: text: Thanks for your suggestions.  As these are all secondary source, review articles, and relevant to this article, I support their addition. Boghog (talk) 09:16, 3 December 2018 (UTC)
thread_title:  Reference and Example Section Improvements 

message: Mechanism second messenger 197.231.201.204 (talk) 11:45, 10 January 2022 (UTC)
thread_title:  Biology
Talk:Signal recognition particle

message: Using 'endoplasmic reticulum' over and over is tedious and makes the wording unwieldy and unclear. We should change some to 'ER', as is custom even in scientific papers, but I am unfamiliar with the wikipedia abbreviation rules.  —Preceding unsigned comment added by 128.54.50.47 (talk) 20:17, 29 October 2007 (UTC)
thread_title:  Could abbreviate ER 

message: The introduction says "specific" proteins, but later it sounds like all new/nascent proteins have the n-terminal that SRPs bind to. Can we clarify please. - Rod57 (talk) 09:51, 15 May 2022 (UTC)
thread_title:  Does this apply to all new proteins or which ones 

message: How does the release of the protein into the ER allow the ribosome to make more protein ? Is there one SRP per ribosome ? - Rod57 (talk) 09:55, 15 May 2022 (UTC)
thread_title:  How is the protein synthesis enabled
Talk:Sister chromatids

message: What do people think about this page being merged into chromatid? Seems both stub articles are directed at precisely the same topic. Cesiumfrog (talk) 23:34, 10 November 2011 (UTC)
replies: text: Seems like a good idea to me. --JonathonSimister (talk) 07:56, 19 December 2011 (UTC)
thread_title: Untitled

message: This page needs an etymology section. Firestar464 (talk) 01:25, 17 March 2021 (UTC)
thread_title:  Etymology
Talk:Calendar of saints (Armenian Apostolic Church)

message: This article reflects the correspondence between the Calendar of Saints of the Armenian Church for the year 2007 only. It would be logical to use in this article the dates as they are used in the Armenian Church. Debresser (talk) 11:03, 23 March 2011 (UTC)
replies: text: It would be, as someone has titled it "2016".  What is the real calendar used? --Richardson mcphillips (talk) 16:13, 15 February 2017 (UTC)
thread_title:  Out of date
Talk:Spermatogonium

message: Another photo with higher magnification, showing germ cells should be added.
194.27.138.2 (talk) 05:46, 16 May 2012 (UTC)
thread_title:  Histological microphotograph is appropriate for a broad view but not for observing cytological morphology 

message: Where is the germinal epithelium? Isn't germinal epithilial cells supposed to be before spermatogonia.  — Preceding unsigned comment added by Behgal.jai (talk • contribs) 15:03, 29 November 2013 (UTC)
thread_title:  Germinal epithilium
Talk:Spermiogenesis

message: "A glycoprotein coat over the acrosome prevents the sperm from fertilizing the egg prior to travelling through the male and female reproductive tracts." 
I think this line needs rewriting, the main factor stopping a sperm fertilising the egg before leaving the testis is obviously that there's no eggs in the testis, not that there's a glycoprotein preventing it.. I assume the line means there's a glycoprotein coat over the acrosome that keeps it dormant until capacitation so it doesn't release the acrosomal enzymes prematurely; but I haven't heard of this glycoprotein before, so I won't rewrite it myself.--KX36 (talk) 15:08, 12 May 2008 (UTC)
thread_title:  Acrosome glycoprotein prevents fertilisation before leaving the testis? I don't think so. 

message: Possibly could link to the orphan article http://en.wikipedia.org/wiki/GAPDHS ? Discordianchao5 (talk) 23:27, 25 March 2011 (UTC)
thread_title:  Link to Orphan Article 

message: Define the term spermiogenesis discuss the conversion of spermatids into sperm? 2409:4042:228C:BF2F:0:0:106A:60AD (talk) 18:10, 15 July 2022 (UTC)
thread_title:  Define the term spermiogenesis discuss the conversion of spermatids into sperm
Talk:Stellate cell

message: Hey, I just did some edits, adding the fact that a "stellate cell" is not always a cerebellar stellate cell, but also cortical ones (and possibly other ones I don't know of). I added a current clamp recording of a cortical spiny stellate cell, which may or may not be useful in other neurosci applications. If anyone has like, a biocytin fill or something nice and anatomical, that would add a lot (I'll try and get a current clamp recording of a cerebellar stellate cell next time I make cerebellar slices Bilz0r 08:06, 6 July 2007 (UTC)
thread_title: Not just in the cerebellum

message: I propose a different Wikipedia page for each type of stellate cell. This page would remain to describe what the term "stellate" means, and to link to the other pages.
198.202.70.227 (talk) 01:25, 11 January 2008 (UTC)
thread_title:  Propose splitting into separate pages
Talk:Suicide gene

message: I am improving the page of the 'suicide gene' for a class project under the supervision of Mr. Travis Bohrer (tbohrer74) at Waynesville High School. I am a Wikipedian and therefore you will be identified as a bona fide. -- user:StevenPablo30 08:27, 18 March 2013 (UTC)
thread_title:  notify 

message: — Assignment last updated by Kulkarni2022 (talk) 21:18, 3 September 2022 (UTC)
thread_title: Wiki Education assignment: Molecular Genetics
Talk:Synaptogenesis

message: I'm not sure this is either correct or useful. Doubtless new synapses form at higher rates in young animals, but many of these rapidly disappear again. I think the total number slowly increases up to the end of puberty. Also, the numbers change at different times in different cortical areas. For example according to http://www.ncbi.nlm.nih.gov/pubmed/3583840
synapses in striate cortex peak at 8 months and then slowly fall by only 40% in the next 10 years, then remain stable. In frontal cortex (http://www.jsmf.org/about/j/neural_connections.htm), the peak density is reached at 3.5 years. Note that though there is a decline in density, the volume of the cortex increases up to 7 years, so the total number may not change much.
There is a rather rapid increase in synapse number during the months before and immediately after birth, but this is not surprising: new cortical neurons are being formed!
Paulhummerman (talk) 20:47, 13 January 2012 (UTC)
replies: text: There is not really anybody actively maintaining this article at the moment, so please feel free to fix any problems that you spot.  If I can be helpful please let me know.  Regards, Looie496 (talk) 04:07, 14 January 2012 (UTC)
thread_title: "Explosion"?
Talk:Miller Place, New York

message: *Changed the Pirate House caption. "Eclectic" is not the right word, I believe you are looking for "Eccentric"
**Eccentric can be taken to be an insult.  Eclectic, using a variety of sources was the right word, considering the styles of pirates, vikings, hawaiian dancers, etc.  However, to remove any controversy, I am restructuring that line to be without any adjectives whatsoever.  Iracaz 23:10, 10 March 2007 (UTC)
thread_title:                      
Talk:Codocyte

message: I can see nothing in the first paragraph of the gene therapy section that has anything to do with codocytes in particular.  I believe this part of this section should either be merged into Gene therapy or deleted entirely.
Headzred 16:04, 1 September 2007 (UTC)
thread_title: Relevance of Gene Therapy

message: I moved HbC disease and thalassemia closer to the mention of iron deficiency.  This keeps asplenia from interrupting the idea.  71.234.109.192 08:38, 17 October 2007 (UTC)
thread_title:  Diseases 

message: Omgitsrhys (talk) 15:21, 22 November 2011 (UTC)
thread_title:  autosplenectomy causing anemia 
Talk:Summer of the Seventeenth Doll

message: "The play is almost unanimously considered by scholars of literature to be the most historically significant in Australian theatre history, . . "
Opening paragraph, Wikipedia article:
"Summer of the Seventeenth Doll is a pioneering Australian play written by Ray Lawler and first performed at the Union Theatre in Melbourne, Australia, on 28 November 1955. The play is almost unanimously considered by scholars of literature to be the most historically significant in Australian theatre history, openly and authentically portraying distinctly Australian life and characters. It was one of the first truly naturalistic "Australian" theatre productions."
Where are you going to jump, dear reader?  To the side where you know there is almost unanimity? Or to the side of those few scholars of literature who do NOT consider the play "to be the most historically significant in Australian theatre history."
Who are they . . these few scholars of literature who do NOT consider the play to be the most historically significant in Australian theatre history?
Where are they?
What is their story? Or, better, their critique?
--Laurencebeck (talk) 07:33, 16 August 2012 (UTC)
thread_title:  "almost unanimously"
Wikipedia talk:Requests for adminship/Mehrshad123

message: Edit statistics for Mehrshad123:
Mainspace	81
Talk:	14
User talk:	14
Wikipedia:	4
avg edits per article	2.69
earliest	17:55, 22 April 2005
number of unique articles	42
total	113
2005/4 	8 	
2005/5 	0 	
2005/6 	0 	
2005/7 	2 	
2005/8 	1 	
2005/9 	0 	
2005/10 	9 	
2005/11 	0 	
2005/12 	1 	
2006/1 	1 	
2006/2 	0 	
2006/3 	2 	
2006/4 	4 	
2006/5 	0 	
2006/6 	1 	
2006/7 	2 	
2006/8 	0 	
2006/9 	1 	
2006/10 	8 	
2006/11 	18 	
2006/12 	26 	
2007/1 	9 	
2007/2 	20
Editcount run using Wannabe Kate's tool on 21:55, 14 February 2007 (UTC)
Talk:Necco

message: NECCO makes Canada wintergreen mints too, right?  I am trying to find out what about them is "Canadian"  --134.88.233.232 21:58, 14 February 2007 (UTC)
thread_title: Canada

message: According to the company's logo, the name is Necco, not NECCO.  I wasn't sure how to change the name of the article, but I cahanged all instances of NECCO to Necco in the article. 162.136.192.1 (talk) 14:10, 14 February 2008 (UTC)
thread_title: Name

message: Did Necco manufacture Sweethearts for use by Brach's? They look very similar down to the text being in red. If yes, should this be included in the article? THX1136 (talk) 17:16, 27 December 2023 (UTC)
thread_title:  Sweethearts
Talk:Transition (genetics)

message: can anyone provide more clues on why transition is more frequent to observe than transversion? surely transition is chemically more likely to take place, but I think that transversion is also more easily recognized and corrected by cell repair machinery, isn't it?  — Preceding unsigned comment added by 193.145.56.241 (talk) 19:52, 13 September 2012 (UTC)
thread_title: transition/transversion rate
Talk:Trypan blue

message: CAS lists this CAS# (72-57-1) and name as the tetrasodium salt, but we have the free acid shown.  Can someone confirm which one is the dye? Walkerma (talk) 05:20, 20 January 2009 (UTC)
thread_title:  Sodium salt or free acid? 

message: PubChem claim that the TB molecular weight is 960.8 g/mol, not 872.88. Please confirm and update. Akokustatal (talk) 08:45, 9 January 2020 (UTC)
replies: text: Check the chemical formula.  The relative molecular mass has to be consistent with that.  —DIV Support good-faith IP editors:  insist that Wikipedia's administrators adhere to Wikipedia's own policies on keeping range-blocks as a last resort, with minimal breadth and duration, in order to reduce adverse collateral effects;  support more precisely targeted restrictions such as protecting only articles themselves, not associated Talk pages, or presenting pages as semi-protected, or blocking only mobile edits when accessed from designated IP ranges.  (1.145.44.122 (talk) 11:03, 2 November 2023 (UTC)
thread_title:  Molecular mass
Talk:Casein kinase 2

message: I am a fourth year student doing a BSc in Genetics and Medical Science. Over the next few week I will be adding to this article in the hopes of expanding it with relevant and useful information. Following are 4 sources I plan on pulling information from, I will update this list as I add more but any feedback on the credibility of these sources or issues with these sources being used would be greatly appreciated. Cheers. 
Litchfield, D.W. (2003). "Protein Kinase CK2: Structure, Regulation, and Role in Cellular Decisions of Life and Death". Biochem, J. 369: 1-15.
Gyenis, L., Litchfield, D.W., and Rabalski, A.J. (2016). "Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells". Clin. Cancer Res. 22(12).
Litchfield, D.W., Nuñez de Villavicencio-Diaz, T., and Rabalski, A.J. (2017). "Protein Kinase CK2: Intricate Relationships Within Regulatory Cellular Networks". Pharmaceuticals. 10(27).
Litchfield, D.W., Gabriel, M., Gloor, G.B., Li, S.S., St.Denis, N., Turowec, J.P., and Gingras, A.C. (2015). "Systemic Investigation of Hierarchical Phosphorylation by Protein Kinase CK2". Journal of Proteomics. 118: 49-62. 
Jarrod Heffernan (talk) 16:20, 19 October 2017 (UTC)
thread_title:  Greetings/Feedback
Talk:Phosphorylase kinase

message: There is a contradiction here. First, it is said that subunits alpha and beta have the phosphorylation sites, affected by PKA. Later, a sigma subunit appears and is said to be the phosphorylation site.
Furthermore, first it is the delta subunit that binds calcium, later it is the beta subunit.
What I've read in the books matches what is said in the introduction rather than what is said under 'Regulation', buut I haven't done a thorough review of the topic.
--AngelHerraez (talk) 20:32, 15 March 2010 (UTC)
thread_title: Untitled
Talk:Derby Lunatic Fringe

message: Please keep in mind that this article is only about the Derby Lunatic Fringe. General information about hooliganism, football hooliganism, hooligan firms or other related topics belong in their own appropriate articles. Spylab 22:06, 14 February 2007 (UTC)
thread_title: Off-topic content

message: I deleted the sections about events from the 2000s, because they were simply collections of copy and pasted news articles, without any references showing where the stories were originally published. Directly pasting articles into Wikipedia violates copyright law, and those particular articles weren't written in encyclopedic style. Spylab 20:25, 19 February 2007 (UTC)
thread_title: Plagarism

message: This is interesting stuff but could be true, untrue, or only partly true. Attribution to reliable sources would greatly improve this article. Finetooth 22:29, 14 August 2007 (UTC)
replies: text: Which is why the citation tags were added. ♦Tangerines♦·Talk 01:54, 15 August 2007 (UTC)
thread_title: Attribution
Talk:Angelo Carletti di Chivasso

message: In bibliographic circles the subject is commonly referred to by the Latin form of his name - Angelus de Clavasio.  I have added a sentence to introduce this, also created a redirect from the Latin form to this page..
Supporting evidence comes from the linked edition of his 'Summa'.John M Brear (talk) 18:01, 10 May 2014 (UTC)
thread_title:  Latin form of name 

message: Is there other evidence for a 1476 date for the first edition of the Summa... ?
Does this refer to its production in manuscript?
Searching the British Library Incunabula Short Title Catalogue gives the earliest printed edition as 1486 (printed by de Suico in Chivasso - apparently the only incunabulum printed there).
I have a copyright-free image of a page from the 1486 which I will upload if nobody objects.John M Brear (talk) 18:09, 10 May 2014 (UTC)
thread_title:  First edition of the Summa
Talk:Myosin light-chain kinase

message: Addition to the intro:
Numerous forms of MYLK come from the same original transcript but are then modified postranslation in vivo Thus while there are only 4 different genes for MYLK, post translation modifications account for the major diversity of MYLK amongst different cells.
Add a section about Myosin light chain kinase mutation and diseases that arise as a result of misfunctioning. 
1.Pulmonary disorders: inability of MYLK to function properly in lung cells creates an imbalance in mechanical forces between adjacent Endothelial and lung tissue cells. An imbalance may result in acute respiratory distress syndrome, in which fluid is able to pass into the alveoli.
a.Within the cells, MYLK provides an inward pulling force; cell-cell adhesion via tight and adherens junctions, along with anchoring to Extra Cellular Matrix (ECM) via integrins, and focal adhesion proteins results and outward pulling force. 
b.Myosin light chain pulls the actin stress fiber attached to the cadherin, resisting the force of the adjacent cell’s cadherin. 
Peer review
The structure of this article flows well. It has a logical intro with supporting details in the sections following that make it easy to understand. There are a few areas lacking citations, namely the statement in the introduction about the diversity of MYLK, the entire section about function, and the paragraph under mutations discussing pulmonary disorders.
For improvements to the page, the introduction makes note of a great diversity of MYLK due to post-translational modifications to the four MYLK genes; however, the section about isoforms only lists the four genes, so it is unclear where the diversity is. Additionally, the isoform section could have some clarification as to what differences there are between the isoforms beside tissue specificity if there are any. Other than these edits, the page is very clear and well-written with appropriate information and graphics. Good luck finishing it up! Ssbusse (talk) 19:30, 6 March 2018 (UTC)
Talk:My Dead Girlfriend

message: http://imdb.com/title/tt0808387/  —Preceding unsigned comment added by 87.122.113.222 (talk) 15:20, 6 January 2008 (UTC)
thread_title:  Film with same name 
Talk:P38 mitogen-activated protein kinases

message: I am part of a Developmental Biology Honors & Graduate Course at Saint Louis University, and I have a few suggestions for your article:
Here is a link to an excellent review on the map kinase, p38, as well as activation of p38 that you may want to include in your page: 
http://www.nature.com/nsmb/journal/v4/n4/pdf/nsb0497-311.pdf
One suggestion may be to go more in depth on inhibition of p38. Also, what are the activation sites, and how many? The link goes into greater detail on that. A picture of the crystal structure of this protein is one suggestion of displaying the activation sites neatly. I noted that the summary after the first heading is cut off by the charts. It might benefit to move that up before the chart so viewers can read the entire summary, and also be more pleasing to the eye.
There also has been much research on how axis specification in certain organisms such as the sea urchin and drosophila depend on p38, which I do not see included in this review. Here are links to a couple primary sources on that:
http://www.ncbi.nlm.nih.gov/pubmed/16319119
http://www.ncbi.nlm.nih.gov/pubmed/10364162
Ayebeesung (talk) 15:35, 11 February 2015 (UTC)
thread_title: Untitled
Talk:G protein-coupled receptor kinase 2

message: who needs to assess these pages to change the category of this? Kitra101 17:25, 18 February 2007 (UTC)
replies: text: The real problem is the diagram outlining the pathway. I have reduced its size to remove the white space, but now it is impossible to read.  I think the diagram needs to be redrawn so it is visually useful at a smaller size, say 400px. David D. (Talk) 20:02, 9 December 2007 (UTC)
replies: text: Just made some changes to help it.  But needs more work. David D. (Talk) 20:14, 9 December 2007 (UTC)
thread_title: Untitled
Talk:Ca2+/calmodulin-dependent protein kinase II

message: The entire article right now is almost solely about CaMKII. Changing the title to CaMKII instead of CaMK would make the page less confusing.   —Preceding unsigned comment added by 152.3.68.7 (talk) 03:39, 25 April 2011 (UTC)
replies: text:  I agree with you on that one. I was kind of confused by the tittle too Rincrate (talk) 04:33, 29 September 2015 (UTC)
thread_title: Changing Title to just CaMKII

message: I'm studying for my psychopathology course at the moment, and I'm reading that the effects of CaMKII autophosphorilation contribute to les CaMKII activity through irreversible inactivation of the enzyme and/or less afinity of CaMKII for the Post Synaptic Density (PSD), in this case leading to a reduction in hippocampal plasticity and LTP. I'm not a neuroscientist/biochemist yet, but doesn't this contradict the statement on the wiki-page, claiming higher CaMKII activity after autophosphorilation? My course materials we're compiled and in certain cases written by M. Joëls, professor at the University of Amsterdam, with numerous publications specializing in hippocampal functions.  —Preceding unsigned comment added by 145.116.1.128 (talk) 23:29, 22 April 2008 (UTC)
thread_title:  Decreased activity instead of increased/elongated activity 

message: Confused by some names for MK2:  Is CamKII also known as MK2, and if so, is this the same as MAPKAPK2?  — Preceding unsigned comment added by 148.177.1.211 (talk) 18:47, 18 April 2016 (UTC)
thread_title:  MK2 

message: "CaMK2D[edit]
CaMK2D appears in both neuronal and non-neuronal cell types. It is characterized particularly in many tumor cells, such as a variety of pancreatic, leukemic, breast and other tumor cells.[35] found that CaMK2D is downregulated in human tumor cells."
This is confusing. First, the reference (35) is on CaMK2B(beta), not delta (D)! Second, in the reference (35), there is not really mentioning of CaMK2B being downregulated in tumor cells.  — Preceding unsigned comment added by 155.91.45.236 (talk) 16:53, 7 June 2017 (UTC)
thread_title:  Last part on CaMKII four isoforms alpha to delta
Talk:Didube (Tbilisi Metro)

message: This actually quite useful info about Didube metro station and its surrounding bus station and railway station can be potentially good start for Didube Bus Station and Didube railway station pages. This info, which was here as far as 2004, can be still valuable, but not specifically for the Didube metro station page. In case you disagree, you can revert the changes.  Sakweb () 18:01, 25 February 2024 (UTC)
thread_title:  Didube Bus Station
Talk:Tyrosin-protein kinase Lck

message: I guess this should be renamed back to "Leukocyte-specific protein tyrosine kinase"; see also LCK disambig. page.Biophys 18:53, 11 November 2007 (UTC)
replies: text: I'd support that! ~ Ciar ~ (Talk to me!) 01:54, 12 November 2007 (UTC)
thread_title: Untitled