Talk:Androstenone

message: "Depending upon who is doing the smelling, it is reported to be an unpleasant, sweaty, urinous smell, a woody smell, or even a pleasant floral  smell."
I see these products sold on eBay but they have negative scents? Sorry, but I am extra interested in seeing sources that back up the description. Did I put up too many tags or are they fine? For such a pheromone, which happens to be a product that sellers sell hundreds of on eBay, to have such negative smells is rather astonishing. --24.255.155.100 05:37, 17 August 2006 (UTC)
replies: text: For questions about the effectiveness of a supposed product, please ask the reference desk. The goal of an article is to provide comprehensive information without bias and therefore without endorsement. --76.214.201.26 06:24, 25 September 2007 (UTC)
thread_title:  Androstenone pheromone smell(s) 

message: Androstenone is growing in popularity applied as a perfume. It is highly effective at having the wearer get sexual attention from women. It inspires lust or disgust depending on the sex, age, sexual orientation, sexual maturity and self-confidence of the person it comes into contact with. It has a smell resembling to urine. Many men who wear androstenone hide its unpleasant smell with a light perfume even though most men can’t smell androstenone. If it is not covered, women may say that the wearer smells ghastly. It may be suggested that androstenone be applied in quantities ranging from 2.5mcg to 7.5mcg depending on the intensity of the desired effect and the type of liquid used to make the pheromone volatile. The quantities may need to be tweaked depending on the “targeted” individual’s reaction to the pheromone. Androstenone gives a strong physical presence, a strong sexual presence, the sexual signal that it is the time to have children and finally, it helps melt away refusal for penetration. Applying much larger doses than may be normally found on highly sexed males may cause fear in some individuals thus making them avoid the wearer of the androstenone perfume. Some males may become jealous towards male’s wearing androstenone because they feel that the wearer is attracting all sexual partners for himself.
User:thomaslavoie
:If you would like to include a section about its commericial use, please use references. Wikipedia discourages original research and that's probably why that was removed. --76.214.201.26 06:21, 25 September 2007 (UTC)
thread_title:  Androstenone as a pheromone perfume 

message: This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 07:51, 10 November 2007 (UTC)
thread_title:  WikiProject class rating

message: As far as I can tell, the best evidence about perception of androstenone is from the following reference, which isn't mentioned anywhere on this site:  
Genetic variation in a human odorant receptor alters odour perception.
Andreas Keller1*, Hanyi Zhuang2*, Qiuyi Chi2, Leslie B. Vosshall1 & Hiroaki Matsunami2,3
Vol 449|27 September 2007| doi:10.1038/nature06162
Here's the abstract:
Human olfactory perception differs enormously between individuals,
with large reported perceptual variations in the intensity
and pleasantness of a given odour. For instance, androstenone
(5a-androst-16-en-3-one), an odorous steroid derived from testosterone,
is variously perceived by different individuals as offensive
(‘‘sweaty, urinous’’), pleasant (‘‘sweet, floral’’) or odourless1–3.
Similar variation in odour perception has been observed for several
other odours4–6. The mechanistic basis of variation in odour perception
between individuals is unknown. We investigated whether
genetic variation in human odorant receptor genes accounts in part
for variation in odour perception between individuals7,8. Here we
show that a human odorant receptor, OR7D4, is selectively activated
in vitro by androstenone and the related odorous steroid
androstadienone (androsta-4,16-dien-3-one) and does not respond
to a panel of 64 other odours and two solvents.Acommon variant of
this receptor (OR7D4 WM) contains two non-synonymous single
nucleotide polymorphisms (SNPs), resulting in two amino acid
substitutions (R88W, T133M; hence ‘RT’) that severely impair
function in vitro. Human subjects with RT/WMorWM/WMgenotypes
as a group were less sensitive to androstenone and androstadienone
and found both odours less unpleasant than the RT/RT
group. Genotypic variation in OR7D4 accounts for a significant
proportion of the valence (pleasantness or unpleasantness) and
intensity variance in perception of these steroidal odours. Our
results demonstrate the first link between the function of a human
odorant receptor in vitro and odour perception.  —Preceding unsigned comment added by 69.38.231.2 (talk) 21:32, 4 January 2010 (UTC)
thread_title:  Crucial missing info.... 

message: Hello fellow Wikipedians,
I have just modified  on Androstenone. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Corrected formatting/usage for http://www.reuters.com/article/2007/09/16/us-genes-odor-idUSN1522717720070916
*Added archive https://web.archive.org/web/20101017224156/http://newswire.rockefeller.edu:80/?page=engine&id=660 to http://newswire.rockefeller.edu/?id=660&page=engine
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—InternetArchiveBot (Report bug) 12:24, 13 October 2016 (UTC)
thread_title:  External links modified 

message: I'm not sure what's going on in the previous talk sections; seems like 2000s pseudoscience to me.
Anyway...
Certain human sexual scents are processed in the hypothalamus rather than in the olfactory cortex.
The cited source was from 1980 (!) and since then there's been quite a lot of research about this.
For instance:
https://www.ncbi.nlm.nih.gov/books/NBK200984/
https://pubmed.ncbi.nlm.nih.gov/34266600/
So the statements which I marked in the article could be potentially misleading.
RadioactiveBoulevardier (talk) 04:15, 10 February 2023 (UTC)
thread_title:  Human pheromone detection