Talk:Acetylcysteine

message: Apologies for adding this to the "talk" page, but I can't seem to make edits.  Citation number 42 is currently a broken link, should be redirected to: http://www.wjgnet.com/1007-9327/9/125.pdf
--Quickfastgoninja (talk) 21:26, 22 April 2012 (UTC)
replies: text: Change made and unmade -- PMID ref working now. -- Jo3sampl (talk) 22:28, 15 May 2012 (UTC)
thread_title: Broken Link okay now

message: It is my understanding that this is no longer investigational. At least where I come from use is indicated in patients with COPD, recurring exacerbations and chronic bronchitis (productive cough at least three months/year). Reference no 22 is a RCT with clear results and no obvious weakness, or am I missing something?
--GustenNyberg (talk) 13:28, 7 January 2010 (UTC)
thread_title: Use in patients with COPD

message: The article states that NAC helps boost the immune system.  I contest this statement.  I'm taking it out now.  If someone wants to add it back, please give a reference. 
:I provided reference from two RCTs showing that it increases immunity in AIDS. I invite you (or other contributors) to put back a similar statement (to "NAC helps boost the immune system") at the same place it was. You might wish to limit the sentence to AIDS. In the meantime, I'll try and find other research and trials on immunity at large (but you may want to check it out yourself). Pierre-Alain Gouanvic 17:01, 12 March 2007 (UTC)
thread_title: Contesting boost of immune system

message: I added a couple references.  If someone wants to really expand this article, these should be a good jump-off point. :-) Ksheka 23:48, May 9, 2004 (UTC)
:Ah, yes, the references. I could make head nor tails of the 30 references of all stripes and colours... I felt the sensible thing to do was to slash them all and start again. I've also expanded the drugbox. JFW | T@lk 21:32, 28 Nov 2004 (UTC)
replies: text: I wonder if this paper - "Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review." would be a good candidate to address the "[medical citation needed]" in the first paragraph? Smartial arts (talk) 00:36, 22 May 2015 (UTC)
thread_title: More references

message: In accordance with Wikipedia:WikiProject_Drugs naming policy, I propose we move this page to the INN acetylcysteine. If you have any concern with this proposal, please discuss it on this page. Matt 23:07, 21 Dec 2004 (UTC)
thread_title: Move to acetylcysteine

message: The content in Mucomyst is essentially duplicated in acetylcysteine.  Andrew73 02:16, 23 October 2005 (UTC)
replies: text: I just happened by here by accident, but I think this is a good candidate for a merge. Kit 19:13, 10 November 2005 (UTC)
replies: text: Done. JFW | T@lk 13:26, 11 November 2005 (UTC)
replies: text: Looks good to me! Kit 19:01, 11 November 2005 (UTC)
thread_title:  Merging Mucomyst into acetylcysteine 

message: I've been told several times by our local liver unit to use NAc even in liver failure of non-paracetamol etiology.  already mentions this (small series in 8 patients).  disagrees. It's being trialled for acute liver failure. JFW | T@lk 19:37, 20 September 2006 (UTC)
thread_title:  Liver failure 

message: i use this stuff in my eyes for the mucus. perhaps someone with more knowledge than i could add something--Mongreilf (talk) 08:58, 25 May 2009 (UTC)
thread_title:  Ocular use 

message: I don'd understand the fetish that the average person editing this page has with IV acetylcysteine.  The reality is there are major complications that can be completely avoided by giving the oral furmulation.  If you mix it with cola of the patients choice, put it on ice, and make patients drink it out of a straw from a cap with a lid, you will get over 90% of patients to take their entire dose by mouth which avoids all of the nasty potential complications with IV.  —Preceding unsigned comment added by 144.30.70.85 (talk) 19:53, 23 June 2010 (UTC)
thread_title:  Oral versus Parenteral 

message: does anybody know what it does to the SAR?  —Preceding unsigned comment added by 41.34.29.84 (talk) 02:54, 11 January 2011 (UTC)
thread_title:  the use of the acetyl moeity 

message: Im wondering if there is a body enzyme system that produces N acetyl cysteine at the body.  If theres cysteine certainly there are acetylation enzymes  I just wondered if there was a biochemical path that actually made N acetylcysteine at the body
The idea is that genetic variants of that enzymes genes might go with greater longevity as well as less disease  — Preceding unsigned comment added by 163.41.136.51 (talk) 20:00, 9 June 2011 (UTC)
thread_title:  Is there a naturally occuring acetylcysteine at the body 

message: I think the claim for veisalgia attenuating should get some direct sources to support it's claim. The first one is second hand and the other one (Resat Ozaras et al., 2003) doesn't seem to support the direct claim to attenuate veisalgia, mere that "[...] ethanol-
induced liver damage is associated with oxidative stress,
and co-administration of n-acetylcysteine attenuates this
damage effectively in rat model.". 81.232.6.92 (talk) 22:47, 3 November 2011 (UTC)
thread_title:  Sources for veisalgia claim 

message: There used to be an entry related to hangover prevention. Why was it removed? (Personally, I swear by it for preventing hangovers--obviously that doesn't merit inclusion absent a source.)  — Preceding unsigned comment added by 71.163.49.29 (talk) 17:33, 1 September 2012 (UTC)
thread_title: Hangover

message: I see a whole list of "potential" uses for acetylcysteine.  Many are early stage animal experiments.  Given that this is a medical article I suppose that only clinical studies should get a mention. Desoto10 (talk) 05:00, 8 May 2013 (UTC)
thread_title:  Research 

message: As acetylcysteine is primarily used as a medicine I believe we should change the chembox to drugbox. Fuse809 (talk) 04:56, 8 November 2013 (UTC)
thread_title:  DrugBox 

message: Pardon me, but it appears that the 3D-rendered animation used (Acetylcysteine3Dan2.gif) is actually that of ordinary L-cysteine. The stereochemistry's correct, at least. dlainhart (talk) 02:40, 9 December 2013 (UTC)
thread_title:  Incorrect image in description (revolving 3D animated GIF) 

message: The antioxidants caused a 2.8-fold increase in lung tumors, made the tumors more invasive and aggressive, and caused the mice to die twice as quickly - all compared to mice not given antioxidants.
The only article I see about uses both NAC and vitamin E, couldn't it be just vit E's problem? Bowtartar (talk) 12:49, 29 October 2017 (UTC)
thread_title:  bad for you 

message: there is contradictory information on this page stating that research both supports and rejects the drug as a viable treatment for nicotine, both marked with the same citation (as of jul 15, citation 38).
http://news.yahoo.com/antioxidants-including-vitamin-e-promote-lung-cancer-study-190119863--finance.html  — Preceding unsigned comment added by 76.176.108.8 (talk) 12:27, 30 January 2014 (UTC)
thread_title:  contradictory information 

message: I can buy NAC at retailers such as "natural food" stores. I perceive this as a supplement (in terms of regulation), and thus wouldn't the info in the side panel be incorrect? I believe it says rx-only in U.S. right now.
172.58.136.98 (talk) 19:05, 19 December 2015 (UTC)
thread_title:  Non-prescription in U.S. 

message: The article says: "Large doses in a mouse model showed that acetylcysteine could potentially cause damage to the heart and lungs... The dose used by Palmer and colleagues was dramatically higher than that used in humans, the equivalent of about 20 grams per day."  However, Examine.com https://examine.com/supplements/N-Acetylcysteine/ says: "In mice given 10mg/mL N-acetylcysteine (to get a serum level of 16.2+/-4.3μM[70] comparable to a peak concentrations in a human study using thrice daily dosing of 600mg[71])... this is thought to occur at concentrations reasonable close to pharmacological doses of NAC (for cognitive effects)"  What gives?--Clevera (talk) 05:50, 20 March 2017 (UTC)
thread_title:  Human-equivalent dosage for heart/lung damage in mice? 

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thread_title:  External links modified 

message: In this edit
#A pubmed search was added as a reference for a statement I had already referenced with a textbook. Thus unneeded.
#Basically all medications are chemical compounds. It is more useful to state that acetylcysteine is a medication than it is a chemical compound in the first sentence IMO. Expecially as this is one of the worlds most important medications per WHO.Doc James (talk · contribs · email) 02:40, 10 July 2017 (UTC)
replies: text: Seconded. TylerDurden8823 (talk) 06:29, 14 July 2017 (UTC)
replies: text: We should keep the lead in simpler language. Mucolytic is a secondary and less well supported use compared to paracetamol overdose. It basic means "loosens thick mucus". Belong in the body. Doc James (talk · contribs · email) 00:48, 15 July 2017 (UTC)
thread_title: Two issues

message: *Support removing a pubmed search as a reference as it is not appropriate. Doc James (talk · contribs · email) 02:40, 10 July 2017 (UTC)
thread_title: Issue one

message: *Support calling it a medication in the first sentence. Nearly every medication is a chemical compound (maybe all) and thus calling it that is not needed in the first sentence. Doc James (talk · contribs · email) 02:40, 10 July 2017 (UTC)
replies: text: Seconded. TylerDurden8823 (talk) 06:29, 14 July 2017 (UTC)
replies: text: We should keep the lead in simpler language. Mucolytic is a secondary and less well supported use compared to paracetamol overdose. It basic means "loosens thick mucus". Belong in the body. Doc James (talk · contribs · email) 00:48, 15 July 2017 (UTC)
thread_title: Issue two

message: Out of the blue this statement is inserted, without reference. 
"A clinical trial from 2010, however, found that acetylcysteine is ineffective for the prevention of contrast-induced nephropathy."
This needs citation! Otherwise, I suggest to remove.  — Preceding unsigned comment added by 86.88.106.133 (talk) 04:24, 2 August 2017 (UTC)
thread_title:  On Nephroprotective agent 

message: I heard from someone who takes adderall that there's a common idea in the online nootropic crowd that taking NAC supplements with adderall has some sort of desirable interaction? (ie, somehow changing the effect of the adderall (boosting it? mediating it?)
Obviously, I'd guess that there's most likely no evidence for this, but I came here to this article trying to find info on what exactly this supposed effect is (and who believes in it), so... Kayseychow (talk) 03:34, 15 August 2021 (UTC)
replies: text: Posters on various drug harm prevention pages (e.g the Reddit page for MDMA) claim that NAC helps restore the quality of the mdma experience. Everybody got to be somewhere! (talk) 22:57, 3 June 2023 (UTC)
thread_title:  Supposed interaction of NAC supplements with Adderall/(some? )amphetamines? 

message: Does it exist in nature, or is it a synthetic compound ? —Jerome Potts (talk) 16:05, 18 February 2022 (UTC)
replies: text: When people buy it, it's usually synthesized, but the compound does exist in nature as well, for example in onions. -2003:CA:8729:D2B1:D129:85F:66C4:61CF (talk) 14:27, 26 July 2022 (UTC)
thread_title:  Where does it come from ? 

message: I've restored the section on long covid, which was removed despite being well cited.  The preliminary study from Yale has been extensively covered in the media. -2003:CA:870A:8914:40A5:5D26:257B:B4C5 (talk) 20:33, 22 December 2022 (UTC)
replies: text: That doesn't sound like WP:MEDRS to me. Human-medical reporting needs a high threshold. DMacks (talk) 20:43, 22 December 2022 (UTC)
replies: text: I've added three additional sources, so there are now three secondary sources, plus the primary source of the Yale Medical School researchers themselves.  I therefore see no valid reason for excluding this research, which has received quite extensive coverage. -2003:CA:870A:8921:9916:EB50:F1C1:7542 (talk) 18:46, 23 December 2022 (UTC)
replies: text: MEDRS explicitly rejects popular-press reports on primary research as being valid secondary sourcing, even if the study weren't so preliminary as a 12-patient non-blinded one with no control group. MEDRS consider a case study as even below primary sourcing. DMacks (talk) 18:58, 23 December 2022 (UTC)
thread_title:  Long covid. 

message: Well, NAC pushes the concentration of glutathione. But it will react directly with ((NAPQI)) like any other thiol  (glutathione e.g.) does. 
AND NAC scavenges not only radicals, but heavy metals too. --FK1954 (talk) 21:50, 4 July 2023 (UTC)
thread_title:  Broad spectrum antidote 

message: Text is somewhat disorganized.  For example, psychiatric use should really be in subsections under medical use. Acwilson9 (talk) 01:30, 10 April 2024 (UTC)
thread_title:  Text is somewhat disorganized. 

message: Is there any more recent research, than that already cited, regarding use for treating various compulsive disorders?  (My internist/GP just today suggested using it to alleviate compulsive picking of fingernails and townals, stating that a number of his patients report finding it helpful.) Acwilson9 (talk) 01:34, 10 April 2024 (UTC)
thread_title:  Any more recent research on use to alleviate compulsion disorders?