Talk:Hereditary nonpolyposis colorectal cancer

message: I'd like to create a faq comprised of links to different institutions that offer genetic counseling and specialized medical attention via registries, but I am unsure on the proper format (under external links or appropriate for its own section?)
71.242.244.186 02:34, 9 January 2007 (UTC)
thread_title: HNPCC Registries

message: The previous person to edit this article or maybe even originally write this article had a few style errors in regards to article format (too many bold usages, etc.). I fixed this, and added some relevant academic sources. I also added some interesting information. I don't have time now, but someone should definitely fix the diagnosis and genetics sections of this article. Removal of genetic criteria from the diagnosis section, as well as elaboration of the genetics in the appropriate section, would really make this article worth while. Cheers! WiiAlbanyGirl 08:10, 6 February 2007 (UTC)
thread_title: Housekeeping of the HNPCC Article

message: http://ww5.komen.org/KomenNewsArticle.aspx?id=19327354187  — Preceding unsigned comment added by 78.133.27.31 (talk) 15:36, 1 February 2013 (UTC)
thread_title:  Adding breast and pancreas to list? 

message: I assume these are the same thing. This source suggests so, http://www.ncbi.nlm.nih.gov/pubmed/22782591 but it's a primary source so it's no good to use.
If HNPCC = Hereditary non-polyposis colorectal cancer syndrome then do we need a redirect here?
Also, I offer this content if/where appropriate:
Oral Fordyce spots are more obvious in people with HNPCC, and the most common site is the lower gingiva (gums) and vestibular mucosa.
Lesion (talk) 19:46, 24 August 2013 (UTC)
thread_title:  HNPCC = Hereditary non-polyposis colorectal cancer syndrome ? 

message: This section seems to be quite outdated. There is no mention of (Revised) Bethesda guidelines which are meant to identify candidates for screening by MSI testing (or equivalently IHC). Furthermore Amsterdam Criteria should not be used as screening criteria - they were designed to give a diagnosis when mutation testing was not available so that trials could have some uniformity of inclusion criteria; Amsterdam criteria are not sensitive enough to identify Lynch syndrome. Several countries now screen for Lynch syndrome in colorectal cancer patients (all patients in Denmark; patients aged under 70 in Norway and the Netherlands) and screening has been shown to be cost-effective in these populations in a number of analyses in Europe and America.Ts4079 (talk) 13:37, 1 October 2014 (UTC)
thread_title:  Screening 

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thread_title:  External links modified 

message: Hi guys, would there be consensus to split this into 2 articles? HNPCC and Lynch syndrome are 2 different things. Their only connection is that one increases the risk of the other. What we have now is basically the same as merging "lung cancer" and "smoking" into a single article. Dr. Vogel (talk) 09:42, 29 January 2020 (UTC)
thread_title:  split HNPCC and Lynch syndrome 

message: Hello, we are a group of medical students from Queen’s University (different from the earlier group of students). We are working to improve this article over the next two weeks and will be posting our planned changes on this talk page soon. We look forward to working with the existing Wikipedia medical editing community to improve this article and share evidence. We welcome feedback and suggestions as we learn to edit. Thank you. 
===1. Signs and symptoms===
We propose to insert the following content into the Signs and symptoms#Risk of cancer section: “[Two-thirds of colon cancers occur in the proximal colon], and common signs and symptoms include blood in the stool, diarrhea or constipation, and unintended weight loss … The most common symptom of endometrial cancer is abnormal vaginal bleeding.” Hurriedmammal (talk) 17:50, 3 December 2020 (UTC)
thread_title:  Queen’s University Student Editing Initiative 

message: We propose to insert the following content into the Signs and symptoms#Risk of cancer section: “[Two-thirds of colon cancers occur in the proximal colon], and common signs and symptoms include blood in the stool, diarrhea or constipation, and unintended weight loss … The most common symptom of endometrial cancer is abnormal vaginal bleeding.” Hurriedmammal (talk) 17:50, 3 December 2020 (UTC)
thread_title: 1. Signs and symptoms

message: We propose to make the addition of the following content to the Prevention#Screening section: "For women with Lynch Syndrome, CA-125 biomarker tests can be used as a tool to detect endometrial or ovarian cancer. This test should be done once per year."  19djg3 (talk) 19:41, 2 December 2020 (UTC)
thread_title: 2. Prevention

message: We propose to insert the following content into the Treatment section: "[Surgery remains the front-line therapy for HNPCC], with either a partial colectomy or total colectomy with ileorectal anastomosis. Due to increased risk of colorectal cancer following partial colectomy and similar quality of life after both surgeries, a total colectomy may be a preferred treatment for HNPCC, especially in younger patients."Stjepanovic N, Moreira L, Carneiro F, Balaguer F, Cervantes A, Balmaña J, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 2019 Oct 1;30(10):1558-1571. doi: 10.1093/annonc/mdz233. PMID: 31378807.
Wikithewalrus (talk) 18:29, 3 December 2020 (UTC)
thread_title: 3. Treatment

message: We propose replacing the sentence in the Epidemiology section: “In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2 percent to 7 percent of all diagnosed cases of colorectal cancer.” with the following sentences: “Though the exact prevalence of Lynch Syndrome-causing mutations in the general population remain unknown, recent studies estimate the prevalence to be 1 in 279 individuals, or 0.35%. Certain populations are known to have a higher prevalence of founder mutations, including, but not limited to, French Canadians, Icelanders, African Americans, and Ashkenazi Jews.” We also propose adding the following sentence: “Lynch Syndrome-causing mutations are found in approximately 3% of all diagnosed colorectal cancers, and 1.8% of all diagnosed endometrial cancers.” CMForster (talk) 19:33, 3 December 2020 (UTC)
thread_title: 4. Epidemiology