Talk:Chloramphenicol

message: The relationship between chloramphenicol reactions and benzene-based preservatives seems quite important.  I almost missed this knowledge except for my curiosity of coming to the talk page and noticing that that part had been removed.  I wonder if the original author would please considering restoring this text with required citations.  I know this would take a bit of work, but I found this bit extremely valuable and I think others might as well.  Thanks.  Ssaydjari (talk) 04:03, 16 August 2012 (UTC)
thread_title:  Benzene-Based Preservatives 

message: I have attempted some clarification (i.e. addition of "molecule") and spelling fixes for the "Mechanism and resistance" section.  However, the beginning section is slightly confusing to me, as it may be interpreted to suggest that peptidyl transferase inhibits ribosome activity:
:Chloramphenicol stops bacterial growth by inhibiting the enzyme peptidyl transferase, which inhibits ribosomal activity and protein synthesis.
However, I am guessing that peptidyl transferase does not inhibit ribosome activity...should it be reworded to clarify, perhaps to something like the following?:
:Chloramphenicol stops bacterial growth by inhibiting the enzyme peptidyl transferase; the inhibition of this enzyme results in inhibited ribosomal activity, which leads to inhibited protein synthesis.
--GregRM 04:45, 23 March 2006 (UTC)
thread_title:  Mechanism and resistance 

message: Is Chloramphenicol used in the treatment of animals? —The preceding unsigned comment was added by Frederickwolf (talk • contribs) 19:07, 15 December 2006 (UTC)
thread_title:  Animal use 

message: I've heard that Chlorsig can be an effective treatment to minimise the appearance of scars when applied during the healing process - this was confirmed by a plastic surgeon after a recent procedure. I can't find any reference to this anywhere on the internet however. Has anyone else heard of this use, or have any information about its accuracy? -Orpheus82 03:02, 20 February 2007 (UTC)
thread_title:  Use on scars 

message: Thiamphenicol is not only for use in animal.
In Italy Thiamphenicol is sold under the commercial name Glitisol for human use.
I do not know in other European countries, but is not used only in China.
Try to see the follow link : http://www.torrinomedica.it/studio/schedefarmaci/GLITISOL.htm
--Scayn 20:08, 12 March 2007 (UTC)
replies: text: Thanks, added to the article, and to thiamphenicol as well. Fvasconcellos (t·c) 17:46, 11 May 2007 (UTC)
thread_title:  Considerations on the Thiamphenicol 

message: I wanted to know if someone was treated with Chloramphenicol and did not develop the ailment, does that mean they can be treated again and be safe?  Jokem (talk) 02:25, 21 June 2010 (UTC)
thread_title:  Aplastic Anemia 

message: Removed link to website that is itself unreferenced. Chopped text below:
:Note http://www.patient.co.uk/showdoc/40025037/ suggests the link between chloramphenicol eye drops and aplastic anemia is "not well founded". 
--Gak (talk) 11:20, 29 August 2011 (UTC)
thread_title:  Eye drops don't cause apalstic anaemia 

message: Chloramphenicol is not used first line for staphylococcal brain abscesses.  Cloxacillin (for methicillin sensitive) (or cefazolin) or Vancomycin/Septra/Clindamycin/Linezolid for MRSA  — Preceding unsigned comment added by 99.230.239.72 (talk) 22:52, 19 September 2011 (UTC)
thread_title:  Staphylococcal brain abscesses 

message: The phrase «frequently found as a drug of choice in the third world» primarily, because of the non-neutral term «third world», secundarily, because the sentence lacks any documental references.  — Preceding unsigned comment added by Zigisz (talk • contribs) 00:24, 18 December 2011 (UTC)
replies: text: Third World is the title of a Wikipedia article. If you object to the term, please discuss this at Talk:Third world. Lack of references has nothing to do with neutrality; this is covered by the  tag. --ἀνυπόδητος (talk) 17:35, 28 March 2012 (UTC)
thread_title:  Neutrality disputed 

message: I think some information about the use for treatment of ear infection is necessary as it (antibi otic ear drops) was prescribed to me in Thailand (Chiang Mai) by a pharmacist in 2014. Each drop contains 10 mg of chloramphenicol. 2 to 3 drops three times a day was prescribed.Pierrejcd (talk) 08:10, 28 May 2014 (UTC)
thread_title:  Ear infection addition 

message: Latest mengitis epidemic management guidelines for Africa for N. Mengitidis have a warning box stating that the WHO no longer recommends oily chloramphenicol for bacterial meningitis. I think the page should be updated to reflect this. 
Source: 
http://www.who.int/csr/resources/publications/HSE_GAR_ERI_2010_4/en/
Page 23
NB. This publication has been revised for 2015 despite saying 2010
Ed2975 (talk) 00:11, 1 March 2016 (UTC)
thread_title:  WHO no longer recommends oily chloramphenicol  

message: Substituted at 11:34, 29 April 2016 (UTC)
thread_title: Assessment comment

message: The following is unsourced and was moved here per WP:PRESERVE.  Per WP:BURDEN please do not restore without finding independent, reliable sources, checking the content against them, and citing them, and ensuring that this content has appropriate WP:WEIGHT in the article overall.
Chloramphenicol was originally derived from the bacterium Streptomyces venezuelae, isolated by Paul R. Burkholder from a soil sample collected in a mulched field near Caracas, Venezuela. Dr. Burkholder and collaborators (John ehrlich, Quentin R. Bartz, Robert M. Smith, and Dwight A. Joslyn from the Research Laboratories, Parke, Davis & Company, Detroit) publish the first description of the mold in October 1947, in Science. The title of the paper was: Chloromycetin, a new antibiotic from a soil actinomycete. Dr. David Gottlieb, obtained a similar antibiotic from an actinomycete isolated from a compost soil on the horticultural farm of the Illinois agricultural Experiment Station at Urbana, but investigation of this antibiotic was discontinued on learning of the advanced stage of the research at the Park and Davis Laboratories. Both groups published a paper in J. Bacteriol in July 1948, with the title: Streptomyces venezuelae, n. sp., the source of Chloromycetin.  
This antibiotic was introduced into clinical practice in 1949, under the trade name Chloromycetin. It was the first antibiotic to be manufactured synthetically on a large scale.
-- Jytdog (talk) 04:11, 21 June 2017 (UTC)
thread_title:  Unsourced 

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thread_title:  External links modified 

message: How is this drug produced? I am reading a time-travel novel and this drug was one whipped up from early-modern ingredients and techniques. How can it be done? Paul, in Saudi (talk) 07:44, 25 June 2018 (UTC)
thread_title: Production?

message: The first few lines in the resistance section is a little confusing to read. I'm not sure if there is a typo in there, but it seems like a word or two are possibly missing. ---- Paul K. | MechE | MSY-2 | Chemist | Let's talk 21:47, 19 September 2019 (UTC)
thread_title:  Resistance... 

message: Thought I would post this to compare it with thiamphenicol - https://www.drugs.com/price-guide/chloramphenicol Jokem (talk) 02:06, 18 July 2022 (UTC)
thread_title:  Price of the drug