Talk:Nifedipine

message: :Nifedipine and other calcium-channel blockers may interfere with the normal development of sperm, potentially reducing the fertility of men who take it.   It has been studied by at least one researcher as a potential reversible male contraceptive,  however, it is not being actively pursued as a contraceptive by any major pharmaceutical companies, possibly because of perceptions that publicizing its contraceptive effects would negatively impact sales as a blood-pressure medication, or because an expired patent and the availability of inexpensive generics makes research into new uses an unappealing financial prospect.
:At least one case of possible Nifedipine-induced infertility has been reported in the literature. .
:Couples who are having difficulty conceiving should consult their doctor if the man is taking nifedipine.
:The apparent contraceptive mechanism is an inhibition of the normal mannose  lectin coating of the spermatozoa's outer membrane; this coating is necessary for correct binding with the egg.  This may be caused when a greater-than-normal amount of cholesterol is integrated into the membrane, stiffening the membrane and preventing normal outward migration of mannose from the interior.Goodwin, LO, NB Leeds, I Hurley, FS Mandel, RG Pergolissi and S Benoff (1997) “Isolation and characterization of the primary structure of testis-specific L-type calcium channel: implications for contraception.” Molecular Human Reproduction 3(3): 255-68.Benoff, S (1998) “Voltage dependent calcium channels in mammalian spermatozoa.” Frontiers in Bioscience 3: D1220-40.
This is completely disproportionate to the rest of the article. One researcher pushing it and one case report on infertility make this too obscure for a general encyclopedia. JFW | T@lk 22:54, 10 October 2006 (UTC)
replies: text: I don't think it was right to remove this. Safety warnings are of the utmost importance. --IO Device (talk) 22:10, 22 March 2009 (UTC)
replies: text: Well, i came here looked specifically for this information...   and despite a passing familiarity with mediawiki, i am not a wikipedian.  To me, at least, this is a highly relevant section.   66.173.237.26 (talk) 03:26, 17 July 2011 (UTC)
thread_title:  Male Contraceptive Effects 

message: Tocolysis for pregnancy is an off-label use, not a dosage.—Preceding unsigned comment added by 63.165.50.227 (talk) 20:47, 20 January 2009 (UTC)
thread_title: [Dosing/off-label]

message: Could someone mention Procardia XL dosage form release mechanism.   Specifically that it is a plastic shell with a small opening that lets the drug out slowly.   This is important since the nifedipine is released later and over a different kinetic time period.   Also the shell can form a pseudobezoar within the patient.   --74.179.121.14 (talk) 16:15, 10 April 2011 (UTC)
thread_title:  procardia xl 

message: Is this drug a cyp3a4 inhibitor? I know it is a substrate, but data on whether or not is inhibits said enzyme is contradictory at best. I know it could THEROTICALLY produce inhibition via competing with other drugs for the limited enzyme, but does this translate to having any useful inhibtion activity, and if so would it be worth taking as a inhibitor???  — Preceding unsigned comment added by 24.98.250.155 (talk) 23:18, 14 September 2011 (UTC)
thread_title:  cyp3a4 inhibitor??? 

message: is a review of the GITS system. 2009. A secondary source. JFW | T@lk 23:51, 17 November 2014 (UTC)
thread_title:  GITS 

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thread_title:  External links modified 

message: Citing "Medical uses" > "High blood pressure" > 2nd paragraph:
:Sublingual administration of nifedipine promotes a hypotensive effect via peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death.
Citing https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552217/ > heading "Discussion" > 2nd paragraph:
:Sublingual nifedipine causes blood-pressure lowering through a peripheral vasodilation. It can cause an uncontrollable decrease in the blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, which include cerebral ischaemia/infarction, myocardial infarction, complete heart block and death.
These passages are virtually identical.  So, who copied who?
:I found this post to dr-bob.org from June 14, 2008.  It cites an article from Medscape.com dated December 02, 2002. -- Mentropane (talk) 06:42, 28 November 2019 (UTC)
thread_title:  Hypertensive emergencies