Talk:Probenecid

message: This is an old drug (1951). I wonder how it was noticed that it delay excretion of therapeutic drugs? Maybe this is some type of purine analogue to help gout sufferers; it helps excrete uric acid.
Note that it has some side effects (kidney,liver) but if it hasn't been yanked yet then it's likely got an OK profile. Interestingly, available in China as the ampicillin/probenecid combo, by Chengdu List Pharmaceutical, listpharma.com. If you have expensive ailment it is cheaper to fly to HK or China, buy the medicine OTC, and have a nice holiday on your savings.
regford 01:30, 13 September 2006 (UTC)
replies: text: Rmv'd "ref" that was actually a footnote, with text: "< ref>This is an obvious anachronism. Influence of probenecid on the excretion of penicillin was not known before 1950 when the first proof was published. </ref >", because, ofc, a ref is not a footnote. And because its uncited, and poorly written, but anyways. If somebody has factual info, they should fix the article. Eaglizard (talk) 17:34, 11 February 2010 (UTC)
thread_title:  Start 

message: I think you have the mechanism wrong. http://tmedweb.tulane.edu/pharmwiki/doku.php/probenecid
109.173.173.218 (talk) 13:41, 19 June 2016 (UTC)
thread_title:  OAT vs. URAT 

message: Wikipedia is not a newspaper Wikipedia:What_Wikipedia_is_not#Wikipedia_is_not_a_newspaper, but a recent study indicates Probenecid may be effective in decreasing opiate withdrawal through a novel mechanism in rodents.  This study and novel pharmacological use is unworthy of the main article at this time, but perhaps this information can contribute to the article when appropriate style and additional sources are available.
* nature.com - Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4281.html
* sciencedaily.com - Researchers identify drug that alleviates opioid withdrawal - Existing drug is effective in preventing withdrawal symptoms in opioid-dependent rodents https://www.sciencedaily.com/releases/2017/01/170130110911.htm
* pharmwiki - http://tmedweb.tulane.edu/pharmwiki/doku.php/probenecid
32.217.47.203 (talk) 04:51, 31 January 2017 (UTC)
thread_title:  Decreasing opiate withdrawal 

message: The only thing here is one, admittedly interesting, historical anecdote of specific use.  Where is all the critical historical information around the development?  Things like: when was it invented, who (company/institution and/or actual researchers) developed it, what was the prompt for the research that lead to its development (i.e. were they trying to make a gout medication, a hyperuricemia medication, a co-drug to reduce excretion of drugs paired with it, some combination there of, or were the developers going for something else all together and these effects were all merely serendipitous?)199.94.1.205 (talk) 15:13, 9 May 2018 (UTC)
thread_title:  History Section 

message: New study's come out that points to this drug as a possible antiviral. Here's the URL where I caught the story: 
https://medicalxpress.com/news/2021-09-medicine-gout-covid-.html
Here's the study: 
https://www.nature.com/articles/s41598-021-97658-w
No time/interest to fight the good fight anymore to update articles these days but if someone else wants to take a crack at it and deal with the ankle biters, feel free TMLutas (talk) 19:32, 11 September 2021 (UTC)
thread_title:  New information