Talk:DNA repair

message: Ideas welcome!
prometheus1 12:47, 10 Aug 2004 (UTC)
replies: text: Delighted to have your assistance. prometheus1 07:40, 15 Aug 2004 (UTC)
thread_title: older entries

message: I think there are a couple of things that could be clarified here.
#I get the sense that 'molecular lesion' as a more precise meaning than given in either the earlier link to lesion or the link to molecule here. A link to a stub on 'molecular lesion' would be a good idea.
#* good idea prometheus1 23:18, 24 Aug 2004 (UTC)
thread_title:  DNA damage 

message: I'm kinda thinking that the caloric restriction section should be either 
# taken out 
# moved to it's own entry, or 
# it's relation to DNA repair should be explained more explicitly.
I say this because its connection to DNA repair as it stands seems really sketchy and the caloric restriction section seems kinda thrown in.
But, I'm hesitant to take out an entire section. Any feedback?
: Harvestgalaxy 05:44, 15 Sep 2004 (UTC)
thread_title: Caloric restriction increases DNA repair

message: There are some inaccuracies in the articles about damage and repair. I have made a change to the double strand damage section renaming it "double strand breaks" since damage such as oxidized bases opposite each other are not in themsleves repaired by recombination but must first be turned into a double strand breaks. This creates some incompatibility with the picture provided showing base damage on both strands which appears to have been added to distinguish single versus double strand damage, and I am not sure what to do about it. I believe it will require further editing to distinguish damage which results in chemical changes to the DNA without breaking it, and strand breaks. 
Single strand breaks are incredibley numerous and are rapidly repaired in the cell by religation dependant on XRCC1. This probably requires a mention seperate from the other single strand damage repair mechanisms mentioned.
Also perhaps deserving a seperate mention is trancription coupled NER.
Finally, there is a statement that replicating cells have an additional repair pathway dependant on polymerases. This is misleading. DNA replication of damage creates mutations and repairs nothing. They only allow tolerance of the damage. Repair polymerases are used as part of all the DNA damage repair mechanisms mentioned in the article and are not dependant on the cells dividing and so I believe this statement should be removed entirely.
--Harrison35 04:40, 3 Feb 2005 (UTC)
thread_title:  double strand damage and dna repair 

message: Here is the quote that I have a question about:  "the so-called "junk DNA", this mutagenic repair is less likely to be harmful to a cell than homologous recombination with sequences other than the sister chromatid."
Based on the most recent evidence on how the so called junk DNA is actually useful for putting together various segments of RNA to make proteins, can this sentence still be maintained on the page?  Can someone knowledgeable comment on this please?
--PiKeeper 14:36, 26 October 2005 (UTC)
thread_title: Junk DNA

message: Hi there, I recently found and uploaded a fantastic image :Image:DNA Repair.jpg (see also caption) illustrating of actions DNA ligase in repairing DNA damage. I was going to add it in here, but I notice that DNA ligase is not mentioned in this article(?!). This makes placement of this image a bit difficult. Do you have any objections to me adding in a section on this (very important) repair enzyme?--DO11.10 04:33, 27 January 2007 (UTC)
replies: text: Added at least a wikilink under NHEJ, though that may not help with the image-placement problem. (It is an excellent image though, and definitely belongs here.) In general, this article still has odd omissions in combination with unnecessary specificity elsewhere; I did a fair amount of work on it last summer, but a lot of it was referencing existing text, and it's been subject to edit creep since. Opabinia regalis 05:45, 27 January 2007 (UTC)
replies: text: Thanks for your speedy response. I have just added the image to that section, which seems like a perfectly reasonable spot, but please feel free to change the caption or location as you see fit. Thanks again--DO11.10 19:33, 29 January 2007 (UTC)
thread_title:  Lovely image, but where to put it? 

message: I was thinking that a much more in-depth article could be written on the subject of DNA-Repair evolution, and was considering launching into this article this summer. Assuming that I will do a good job, would this be a useful contribution to wikipedia?  —Preceding unsigned comment added by 75.41.187.29 (talk) 21:43, 30 January 2009 (UTC)
replies: text: sounds like a great idea!
prometheus1 (talk) 04:44, 13 February 2009 (UTC)
thread_title:  Split off DNA-Repair Evolution? 

message: I just have some short remarks and as I don't have time to write properly, I'll post it here... 
One subpathway of BER is the single-strand break repair (SSBR) pathway and even though it does not require the excision of a DNA base, it utilizes the same proteins as BER for DNA resynthesis and ligation. In general, the unique part of SSBR is the need for SSB-processing enzymes like PNKP. It is, as always, more complicated than that, but the repair of single-strand breaks is usually classified as repaired by BER. Nowadays SSBR is becoming more of a concept and the repair is referred to as BER/SSBR, but it might be to detailed information for this section. When I have more time I'll update the BER article with more mammalian details and the known subpathways.
Maybe it should be emphazised that damage caused by ionizing radiation result indirectly from reactive oxygen species formed in the aqueous environment of the cell and consist mainly of single-strand breaks, base damages and some double-strand breaks. All of this information can be found in Friedberg, et al. 2nd ed.
Perhaps 3-methyladenine should be mentioned before 1-methyladenine as it is a much more common type of alkylation? (Newbold, et al. 1980)
Sniffe35 (talk) 15:55, 28 April 2009 (UTC)
thread_title:  Smaller comments 

message: The section of single stranded repair is lacking a lot of information that I plan on expanding with proper sourcing. I plan to expand the three repair mechanisms listed and merge information from excision repair Ideas welcome  DaveJones2 (talk) 16:06, 9 December 2014 (UTC)
thread_title: single-stranded breaks

message: I suggest merging the stub article DNA damage checkpoint into the DNA repair#DNA damage checkpoints section of this article.
Maybe later, if that section ever grows large enough, then we could split it back out into an independent article.
--DavidCary (talk) 23:22, 12 December 2015 (UTC)
thread_title:  merge 

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thread_title:  External links modified 

message: The graphic in DNA repair#Frequencies of epimutations in DNA repair genes is a no-no according to MOS:TEXTASIMAGES. The use of colour to convey information is also an accessibility problem. Can someone tackle converting this to textual form?
LeadSongDog come howl! 19:33, 21 July 2017 (UTC)
thread_title:  Text as images 

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thread_title:  External links modified 

message: I think a section on Mitochondrial DNA Repair would be beneficial. I am planning on submitting a section on Mitochondrial DNA repair as part of my Advanced Molecular Class Wiki Assignment on Thursday 12/7/2017.
--IshDatta (talk) 17:41, 7 December 2017 (UTC)
thread_title:  Content Edit