Talk:Leigh syndrome

message: The paragraph says there's no cure or effective treatment and then almost immediately describes treatments. Why are these things done (the high-fat diet, the vitamins, etc?) Some explanation would be helpful, to clarify an otherwise confusing and contradictory paragraph. 66.26.95.207 (talk) 01:25, 29 September 2011 (UTC)
thread_title: Confused about "treatment"

message: I am almost 100% sure that the cause underlying Leigh`s disease is not a mutation in the mDNA (I also think this must be mtDNA) but that the defect is nuclear encoded. In this case it is autosomal or x-linked recessive inherited.
There are a few types of Leigh's disease. What you're referring to is the X linked Leigh's disease which is not a mutation in the Oxidative Phosphorylation enzymes (which are both on the mtDNA and the nuclear DNA). The X-linked Leigh's disease is a mutation of the gene encoding the E1-alpha subunit of the pyruvate dehydrogenase complex, which is located on the X chomosome. More information on this can be found at OMIM.--Nate 18:54, 18 September 2006 (UTC)
thread_title: Inheritance

message: This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:28, 10 November 2007 (UTC)
thread_title:  WikiProject class rating

message: Hi, just curious if anybody else thinks that the information about Dr. Sanzalone should be removed from this page about "Leigh's disease" and moved to a separate biographical article about her, which doesn't exist at this point as far as I can tell. thanks.  —Preceding unsigned comment added by Fythrion (talk • contribs) 20:13, 3 March 2008 (UTC)
thread_title:  Info on Dr. Marie Sanzalone 

message: OMIM designates it as the latter; maybe because it is caused by so much different mechanisms. --CopperKettle 19:22, 27 January 2010 (UTC)
thread_title: Disease or syndrome?

message: I would like to add these as the references 
https://www.nature.com/articles/ncomms12317?WT.feed_name=subjects_cell-biology
https://www.jstage.jst.go.jp/article/internalmedicine/43/5/43_5_427/_pdf/-char/en Canyouguessmyname (talk) 16:50, 3 December 2017 (UTC)
replies: text: Please, see Wikipedia:Citing sources. Ruslik_Zero 19:58, 3 December 2017 (UTC)
thread_title:  I need to add these links as a citation for what I just added on the treatment section 

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thread_title:  External links modified 

message: "Hypertrichosis is seen in Leigh syndrome caused by mutations in the nuclear gene SURF1.[6]"
Surely this should be Hypertrophic cardiomyopathy a heart condition with links to SURF1 deficiencies not Hypertrichosis excessive hair growth.  — Preceding unsigned comment added by 193.1.229.2 (talk) 11:27, 29 January 2020 (UTC)
thread_title:  Hypertrichosis 

message: My son was diagnosed with Leigh’s at a year old he is now 14 years old and still growing strong he is an amazing and determined wonderful young man the doctors don’t know how he’s lived so long as he was given to the ages of 3 to live he’s my little miracle 2A02:C7E:3A4E:9A00:10B:3852:1F65:575D (talk) 08:26, 28 June 2023 (UTC)
thread_title:  Survival