Talk:Transition state analog

message: Introduction: The first two sentences provide a concise intro to the material.  You should explain the theory behind your statement in sentence 3.  The reference you chose for sentence 3 is not great (does not contain the phrase transition state at all) and the “Transition States, Analogues, and Drug Development” reference would provide a better resource to people wanting more information.  Phrasing in sentence 4 is kind of awkward, consider rewording this.  The last two sentences are not really appropriate for an introduction paragraph.  Consider listing a couple specific transition state analogs and their targets in place of this.  The mechanistic explanation of renin is totally out of place here and I think you should replace the figure too. (Maybe a pymol figure showing a T.S.A. bound in the active site?)
Enzyme Mechanism:  The section about enzymes should be related back to transition state analogs.  The transition state structure section seems to be more in depth than in the actual transition state article so maybe it would be a good addition there; however, it currently doesn’t tie back to transition state analogs.
Examples of Transition State Analogue Design:  I think your figure does a good job at illustrating the design of transition state analogs.  You should try to tie your examples together with an introductory paragraph to this section and make sure each example adds to the narrative.  The examples are informative but are currently just a collection of ideas rather than a story.  
References:  You have a good mix of references.  Make sure to look up formatting for Wikipedia references to eliminate your duplicate references and have a common number each time the reference is used.  
Overall you have added a great deal of information to this article.  You need to work on tying this information together into a more cohesive story about transition state analogs, rather than a collection of ideas.  Some of your paragraphs add knowledge to Wikipedia but do not necessarily fit in this article, at least without developing more narrative first.  
UMMedChemStudent (talk)  —Preceding undated comment added 02:55, 4 November 2013 (UTC)
thread_title: Reviewer Comment #2

message: UMChemProfessor (talk) 01:50, 5 November 2013 (UTC)
thread_title: Additional Comments

message: We change some sentence in the introduction to make it better understand, and we also remove the example in the beginning. To make it more smooth, I also combine the KIE part with QMMM methodology since they are both important for determining the transition state structure which is the main source of reference to design inhibitor. I uses some transmittal  sentence to in link between each section with a short introduction in the last two sections. I also make two figures, to explain the last two examples which shows the enzymatic reaction and the intermediate. I think this is essential background regarding my topic. Therefore, I didn't write too much detain other aspect of the enzyme since the original wikipage has mention a lot. However, I add the disease related to the enzyme which may explain the motivation why we need to design the inhibitor for the enzyme.  — Preceding unsigned comment added by Trcum (talk • contribs) 15:47, 10 November 2013 (UTC)
thread_title: Response to UMChemProfessor

message: Thank you for your suggestions on the overall figure and reference format to make our wiki page looks better. I resized the all figures to 800px to 1000px according to the original figure I made. I set 1000px for the figure in the second example instead of 800px since the resolution looks best in 1000px. We also modified the references according to wiki format. All the duplicated references were also combined to one reference.  — Preceding unsigned comment added by Trcum (talk • contribs) 15:59, 10 November 2013 (UTC)
thread_title: Response to ChemLibrarian