Talk:Histamine

message: Where in the name of all the is holy did this information come from?!  There is not a single source cited in this entire article.  I have flagged this and will be looking for sources.  It would be nice if some emails were sent out to some professors requesting some help with a rewrite.
Foolishben 18:32, 27 November 2006 (UTC)
thread_title: sources

message: I can find absolutely no reference to histapenia or histadelia and the effects listed in any reputable medical sourcebook or database. None of the pharmacists I've worked with have heard of it, either, though I haven't spoken with my physician about it. What are the primary sources for this information? Archmage Brian 14:45, 9 October 2006 (UTC)
thread_title:  Imbalances 

message: What is H substance? The article says it is "held to be similar to histamine; or possibly to be histamine itself" - is this a misconception or a mistake? In other articles it appears to be a synonym for Substance H, which redirects to Hh antigen system. --apers0n 09:16, 7 November 2006 (UTC)
thread_title:  H substance 

message: On the Histamine antagonist page there is mention that Histamine promotes angiogenesis. but there is no mention on this page. So I will add it in along with this reference. http://www.ncbi.nlm.nih.gov/pubmed/7540412  — Preceding unsigned comment added by Haaaa (talk • contribs) 09:22, 8 May 2013 (UTC)
thread_title:  Angiogenesis 

message: Your skin is irritated, the mast cells release histamine, you itch, you scratch.  But how long does it take for the histamine to inactivate?  What modifies this time?  Does scratching inactivate the histamine, or otherwise reduce the itch?-69.87.200.131 00:43, 9 May 2007 (UTC)
thread_title:  Histamine inactivation 

message: Shown to have a role in white blood cell chemotaxis?  I gotta read about this - hook a curious brother up.  —Preceding unsigned comment added by 128.119.168.188 (talk) 07:50, 12 December 2008 (UTC)
thread_title:  chemotaxis 

message: For the TODO list: numerous people are selling "histamine pills", containing DAO as a treatment for food sensitivity.  The claim/trend needs to be documented, along with any supporting/contradicting evidence -- likely on the page on DAO but there should be mention/crosslink here. Also perhaps worth mentioning foods with high histamine content. (71.192.212.78 (talk) 17:48, 14 November 2009 (UTC)
thread_title:  Gastronintestinal and metabolization 

message: I've learned that histamine is a hormone, but the word "hormone" isn't even mentioned in this article. Am I wrong?
--193.157.225.219 (talk) 09:37, 4 June 2010 (UTC)
thread_title:  A hormone? 

message: Worth mentioning that histamine is an active component in various venoms?  Off hand, I can think of stinging nettles and giant centipedes..  —Preceding unsigned comment added by 81.152.255.106 (talk) 20:04, 17 July 2010 (UTC)
thread_title:  Venom 

message: This was added by 
The reference is a website (link) that is rather light on scientific information and is mostly built on the conclusions of  (Am J Clin Nutr 2007). The concept, however, gets only <20 PubMed hits. Most of the literature is from Germany and focuses on a purposed deficiency of diamine oxidase. I have the feeling that this is not a concept that we should introduce without proper discussion, possibly supported with better proof. JFW | T@lk 16:41, 31 October 2011 (UTC)
thread_title:  Histamine intolerance 

message: The Properties section starts off with "Histamine forms color hygroscopic crystals that melt at 84°C". The way the word "color" is used in the sentence does not make grammatical sense. If this is a typographical error, such as omitting the past participle suffix "ed" from "colored", it needs to be changed to "Histamine forms colored hygroscopic crystals that melt at 84°C". If it is not a typo, then whatever variety of hygroscopic crystal a "color hygroscopic crystal" is needs to be explained. Linstrum (talk) 19:57, 23 November 2013 (UTC)
replies: text: This article isn't getting written the right way.  We have reams of unsourced data, and then people go back to fix "bad grammar" without checking....   so far as I know, histamine is white - the salts are white - but I so far haven't seen a citation you can even crystallize the base let alone what color it is.  I used some ad hoc references but really much more needs to be done here to put this into proper order.  Otherwise it's a game of telephone. Wnt (talk) 15:52, 4 January 2015 (UTC)
thread_title:  Properties section 

message: "While histamine has stimulatory effects upon neurons, it also has suppressive ones that protect against the susceptibility to convulsion, drug sensitization, denervation supersensitivity, ischemic lesions and stress.[10] It has also been suggested that histamine controls the mechanisms by which memories and learning are forgotten.[11]"
After reading that, "suppressive effects" didn't seem to be a fitting title, and while I view "protective effects" as better, I don't think it adequately encompassses the last sentence. Thoughts? Erebusthedark (talk) 01:24, 13 March 2014 (UTC)
thread_title:  Suppressive effects --> Protective effects 

message: And I think it would be great if someone proficient in this field could add some data to the article... Ben-Natan (talk) 06:36, 3 January 2015 (UTC)
replies: text: Not prepared to take this on just now, but let me leave a pointer to  as a good source. Looie496 (talk) 15:35, 3 January 2015 (UTC)
replies: text: People? Ben-Yeudith (talk) 15:55, 1 May 2015 (UTC)
thread_title:  I know nothing about Histamine&Appetite regulation 

message: A few sentences would seem warranted about the role histamine plays in eczema-related skin conditions, such as neuro-dermatitis or atopic-dermatitis. Release of histamine upon scratching (pruritis) and so forth.  — Preceding unsigned comment added by 218.102.230.155 (talk) 15:09, 30 April 2016 (UTC)
thread_title:  Atopic Dermatitis 

message: How can the same H1 type receptors cause both smooth cell constriction (bonchoconstriction) and smooth cell relaxation (vasodilatation)? Ca2+ signalling cause constriction.
I think the vasodilatation is caused by the H2 receptors, so the vasodilatation should be removed from the H1 part of the table under 'Mechanism of action' part
193.6.168.249 (talk) 14:13, 16 December 2016 (UTC)
thread_title:  H1 receptor discrepancy 

message: Binding of histamine to endothelium causes contraction of the endothelial cells, leading to increased interendothelial spaces, increased vascular permeability, and leakage of plasma into the tissues. Histamine also stimulates endothelial cells to synthesize vascular smooth muscle cell relaxants, such as prostacyclin (PGI2) and nitric oxide, which cause vasodilation [...] (Abbas et al (2018). Cellular and molecular immunology p.447)
So it seems that histamin primarely increases vascular permeability via endothelial cells contraction and induces Vasodilation via smooth muscle relaxation.
Also In this article we can read that histamine strongly increases vascular permeability via disrupting endothelial barrier 
--Vardos (talk) 16:30, 18 June 2019 (UTC)
thread_title:  Vasodilation 

message: Where do scientists discover and creating histamine? 72.69.243.12 (talk) 06:27, 21 November 2021 (UTC)
thread_title:  Histamine science 

message: It's absurd to see that this section mentions sexual dysfunction in only males. The amounts of certain tissues always varies among individuals, but erectile tissues are usually present in all individuals since birth.
Examples of female erectile tissues include the clitoris and vestibular bulbs.
Input from reliable sources is needed. I found a paper with relevant discussion:
:Histamine receptors in the female reproductive system. Part II. The role of histamine in the placenta, histamine receptors and the uterus contractility
— CrafterNova [ TALK ] [ CONT ] 13:44, 3 October 2023 (UTC)
thread_title:  Missing information about [[female sexual dysfunction]] in the section [[Histamine#Erection_and_sexual_function|Erection and sexual function]]