Talk:Erythropoietin

message: As a class of drug EPO is an Erythropoietin Stimulating Agent (ESA).
Does anybody else see a problem with this statement? lol Leondegrance (talk) 20:48, 11 July 2008 (UTC)
thread_title: Recursion

message: could increased haemoglobin (as a result of lung disease i.e increased producfion of 'erythropoietin' by bone  marrow, be a cause of high blood pressure?.
No.GiollaUidir 11:23, 23 March 2006 (UTC)
replies: text: Indeed no, but the hematocrit gets higher and hyperviscosity may develop in extreme cases (rare). JFW | T@lk 16:57, 23 March 2006 (UTC)
thread_title: could

message: I'm really not sure about the pronunciation given here - although it may be the US form. I'm adding a British version. Wee Jimmy (talk) 12:15, 26 September 2014 (UTC)
thread_title:  Pronunciation 

message: I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
replies: text: Indeed no, but the hematocrit gets higher and hyperviscosity may develop in extreme cases (rare). JFW | T@lk 16:57, 23 March 2006 (UTC)
thread_title: Veterinary use

message: The pronunciation as I added was exactly according to Wikipedia style guide. The current revision isn't. Your statement that it's "more common IPA representation style" may be correct, but let's follow Wikipedia style guide, OK? MrTroy 11:28, 15 April 2006 (UTC)
thread_title:  Pronunciation 

message: I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
thread_title: Veterinary Use

message: 13.0 g/ml seems to low a number here.  I don't have full text access to the article, but the abstract would seem to indicate normal is 13.0 - 15.0 g/dl.  Anyone care to expand or correct?
Ganesha 04:42, 11 April 2007 (UTC)
replies: text: EPO is a reasonably safe way to increase hgb from "very low" to the bottom end of the normal range.  Trying to reach the middle of the normal range is unsafe.  The goal should normally be somewhere between 10 and 12 g/dL.  (Remember that you're just trying to avoid a need for a blood transfusion with this.  It doesn't really "make you feel better" or "give you more energy.")  WhatamIdoing (talk) 01:08, 18 February 2008 (UTC)
thread_title: Adverse Affect

message: How long does a change in altitude take to cause EPO to restore oxygen availability?
: You may also wish to try  Wikipedia's Reference desk for questions such as this.  Best wishes. Marycontrary 13:56, 25 July 2007 (UTC)
thread_title:  time to take effect 

message: I am not scientifically qualified to make edits on this page, but I am knowledgeable enough to know that EPO and recombinant EPO are not the same.  The main EPO page discusses blood doping as if the natural hormone EPO is what's being abused, when in reality, it is the artificial hormone found in drugs such as epogen.  I think people use the term "EPO" too generically and confuse naturally occuring EPO with the rEPO drugs which are widely abused by endurance athletes.  The page should refer people interested in the topic of blood doping to a page on recombinant EPO.
:I think the second paragraph of the article identifies the difference and the proper nomenclature: ESA.BillpSea (talk) 21:25, 2 August 2008 (UTC)
replies: text: No, the second paragraph does not make a distinction.  It actually encourages the confusion with the following statement: "This substance was finally purified and confirmed as erythropoietin, opening doors to therapeutic uses for Epo in diseases like anemia."  Because it does not discuss the development of recombinant EPO versus naturally occuring EPO.  This shortcoming of the article helps propogate the misconception that "EPO" is a drug.  Recombinant EPO is a drug, but EPO itself is a naturally occuring hormone.
I think the article is very poorly written, and uses nomenclature in a very simplistic way.  —Preceding unsigned comment added by 205.241.11.6 (talk) 20:36, 15 August 2008 (UTC)
thread_title:  Erythropoietin and blood doping 

message: The article didn't really go into the process of how EPO is made and used in the lab. I'm trying to find some sites, but nothing seems to be coming up. 99.230.7.159 (talk) 17:58, 2 April 2009 (UTC)
thread_title:  Genetic Engineering 

message: First paragraph: "...it is produced by the peritubular capillary endothelial cells in the kidney..."  Several USMLE review books that I've seen say this same thing, but it looks like they're actually produced by fibroblasts in the cortical interstitium.  See http://www.ncbi.nlm.nih.gov/pubmed/9402140 and http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18575881 
Can anyone find evidence to dispute this? Sirmky (talk) 06:46, 28 September 2009 (UTC)
thread_title:  Location of production 

message: This article currently is very confusing because it mixes information about the endogenously produced erythropoietin hormone and recombinantly manufactured erythropoetin that is administered as a drug.  Hence I propose that this article focus on the erythropoietin gene/protein and the drug specific parts be move to Epoetin alfa (analogous to the insulin and insulin therapy articles).  Furthermore this article should conform to WP:MCBMOS while the drug specific article should conform to WP:PHARMMOS. Boghog (talk) 05:45, 12 April 2012 (UTC)
replies: text: Since no one has objected to the above suggestion, I have gone ahead and moved thhe drug specific material from Erythropoietin to Epoetin alfa and reorganized both articles a bit. Boghog (talk) 06:14, 21 July 2012 (UTC)
thread_title:  Proposal to move portions of this article to [[Epoetin alfa]] 

message: "The report contained affidavits from numerous riders on the team including Frankie Andreu, Tyler Hamilton, George Hincapie, Floyd Landis, Levi Leipheimer, and several others describing wide spread EPO use during the Tour de France and other bicycling races around the turn of the century. They also implicated Lance Armstrong."
USADAs report is not focused on widespread EPO use in the peleton. Its primary focus is this: that Lance Armstrong: (i) cheated, and (ii) the necessary corollary: that Lance Armstrong is a liar. They did not "implicate" Armstrong. USADA and USADAs witnesses, who have testified on pain of perjury state openly and clearly that Armstrong is a drug cheat. No "implication". No innuendo. it's not as if his name was mentioned in passing and he was 'implicated' in the event, but he's clearly innocent. no no no. Given the evidence and Armstrong's lack of testimony, he has effectively entered a guilty plea as far as USADA and the UCI are concerned.
It is patently obvious that Armstrong's PR machine (guys you can't win the editing war - you are paid whereas wiki users are not. we'll be here forever reverting the changes) or the few supporters he has are making these pro-armstrong edits despite the overwhelming evidence to the contrary. nearly the whole US Postal and Discovery channel have admitted to using performance enhancing substances - lance armstrong is the only one, according to his story, who is clean.
guys, USADA is very clear on this point: Armstrong is a cheat. Fact. Period. 
Captainandrewwiggins (talk) 22:48, 7 November 2012 (UTC)
thread_title:  Armstrong afficiandos creating biased POV 

message: ...suggests that EPO may not work as a performance-enhancing drug: http://www.eurekalert.org/pub_releases/2012-12/w-edi120412.php
Probably worth mentioning on this page? ed g2s • talk 17:21, 16 January 2013 (UTC)
thread_title:  Recent evidence 

message: There really needs to be actual chemical structure or name, including the specific amino acid sequence, the genes involved, and the types/locations of glycoslyations (the terms alfa, beta, etc. are virtually meaningless, with no explanations given even on their respective pages). The synthesis and regulation section only talks about regulation, not the actual synthesis or process for different glycosylations. The PDB structure is colorized but does not indicate the various atoms or even which parts are protein and which are glycans. Lakshwadeep (talk) 21:58, 23 April 2013 (UTC)
thread_title:  Structure and Chemistry Lacking 

message: There seem to have been no objections to merge a page for an EPO brand (Dynepo) into this generic page since it was proposed in June 2014. It seems like a good idea to me, as there is little specific on that page.Klbrain (talk) 19:27, 31 August 2015 (UTC)
thread_title:  Merge Dynepo in 

message: The article currently states 
'Synthetic EPO is believed to have come into use in cycling about 1990'
In the book 'Het laatste geel', former professional Mathieu Hermans admits to using EPO during the 1989 Tour de France. He adds that he did nothing illegal, as it was not yet on the banned substances list yet.  — Preceding unsigned comment added by 195.22.11.246 (talk) 13:05, 2 October 2015 (UTC)
thread_title:  Beginning of EPO use in cycling 

message: Hello fellow Wikipedians,
I have just added archive links to  on Erythropoietin. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20121016045710/http://www.bbc.co.uk:80/programmes/b01ngqxd to http://www.bbc.co.uk/programmes/b01ngqxd+
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
Cheers. —cyberbot IITalk to my owner:Online 09:56, 17 October 2015 (UTC)
thread_title:  External links modified 

message: Not everyone is going to like my attempt to detach the physiological role of erythropoietin and its pharmacological use, but I think it is needed. The content about pharmacological use and misuse is now on Erythropoiesis-stimulating agent (taken from ). Happy to be shot down, but I think it is helpful. JFW | T@lk 11:41, 17 February 2016 (UTC)
thread_title:  Stuff moved to [[Erythropoiesis-stimulating agent]] 

message: User:IiKkEe this article should follow WP:MCBMOS in its structure. Jytdog (talk) 20:37, 8 September 2017 (UTC)
replies: text: (talk) If I have inadvertently done something wrong, please fix it with an edit.      Regards IiKkEe (talk) 20:49, 8 September 2017 (UTC)
replies: text: (talk) I have reviewed my edits: I have not changed the structure of this Article - all my edits were within Sections. I plead "not guilty". Are you seeing something that I am missing? Regards IiKkEe (talk) 23:44, 13 September 2017 (UTC)
thread_title:  Sections 

message: I fail to see any need for this unrelated 
LINK to Jehovah's Witness and Blood Transfusions  — Preceding unsigned comment added by 137.118.161.59 (talk) 14:33, 20 February 2022 (UTC)
thread_title:  LINK to Jehovah's Witness and Blood Transfusions