Talk:Andrew Fire

message: There seems to be a deliberate policy of linking the article about any Nobelist to all the other nobelists from the same time period. All WP really needs is a chronological table, which WP has, in several versions. I assume the links are done programmatically from the templates?  Can  someone explain any possible use of this?DGG 01:29, 3 October 2006 (UTC)
thread_title:  what links here 

message: I have removed the following text that had been recently added by Xuanwu, since it is an inappropriate and subjective editorialization in this article on Prof. Mello's achievement:
"Mello and Fire's research was directly based on the work of a team lead by two Indian scientists, Dr. Utpal Bhadra and Manika Pal Bhadra. Together with a third researcher, Dr. Jim Birchler, they described gene silencing in animals in a Cell article published in 1997, a year before Fire and Mello's landmark paper.[3] According to Dr. Bhadra, "The work of Andrew and Craig is based on the research of my team from University of Missouri." [4]"
The Bhadra et al. 1997 Cell paper makes an interesting demonstration in an animal system (Drosophila) of the phenomenon of cosuppression, as it was known at the time, albeit without providing much mechanistic insight into the process responsible. This phenomenon had previously been observed only in plants and fungi, but although Bhadra et al. showed that it existed in animals, the phenomenon remained puzzling and unexplained.
The real breakthrough in this field was provided by Fire and Mello in their 1998 Nature paper. Working in C. elegans, they made the crucial demonstrations that (1) gene silencing depended on duplex RNA containing sense and antisense strands homologous to the target mRNA; (2) gene silencing mediated by dsRNA was specific and could be used as a general tool for gene silencing; (3) dsRNA-mediated gene silencing appeared to be catalytic, suggesting the existence of an endogenous enzymatic mechanism for this process.
The work of Fire and Mello was performed in an entirely different system from that of Bhadra et al. and was really entirely unrelated, other than the fact that the effect described by Bhadra et al. may have had a similar basis. In fact, the Fire and Mello paper was a direct extension of several earleir papers on RNA-mediated gene silncing from Fire's group. If the Bhadra et al. observations were indeed a manifestation of RNAi, their data suggesting a dependence on polycomb group proteins is curious, since their is no known role for this protein family in RNAi.
Ve ri tas 06:15, 5 October 2006 (UTC)
thread_title:  Removal of inappropriate addition 

message: This biography of Andrew Fire should be improved. I have add {{Infobox Scientist and other information. More information should be included. Masterpiece2000 (talk) 13:23, 12 December 2007 (UTC)
thread_title:  Improvement 

message: Hello fellow Wikipedians,
I have just modified  on Andrew Fire. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20061102223642/http://www.umassmed.edu:80/administration/uploads/Fire_and_Mello_Nature_1998.pdf to http://www.umassmed.edu/administration/uploads/Fire_and_Mello_Nature_1998.pdf
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thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 3 external links on Andrew Fire. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20061206221430/http://www.umassmed.edu/pap/news/MelloPrize.aspx to http://www.umassmed.edu/pap/news/MelloPrize.aspx
*Added archive https://web.archive.org/web/20061010025712/http://mednews.stanford.edu/releases/2006/october/nobel.html to http://mednews.stanford.edu/releases/2006/october/nobel.html
*Corrected formatting/usage for http://www.umassmed.edu/administration/uploads/Fire_and_Mello_Nature_1998.pdf
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thread_title:  External links modified