lflage/wiki-talks huggingface dataset:
Talk:Pityriasis lichenoides chronica

message: This article was categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 02:54, 15 January 2009 (UTC)
thread_title:  Article categorization 
Talk:Michelle McManus (politician)

message: The phrase "internet hunting" needs to be explained
I added the definition of internet hunting, by the way you should always sing your posts by using four tildes. --Karrade 23:41, 13 March 2007 (UTC)
thread_title: Internet hunting?

message: Are official congressional photos public?
If so, this is a link to hers.
http://www.senate.michigan.gov/gop/senators_headshots/McManus.jpg
I'm not really sure where they fall.
Thanks.
Good Tidings - Navarro (talk) 00:55, 12 June 2008 (UTC)
thread_title: Photo

message: Michelle is no longer in the Michigan Senate.  The page needs to be updated.
This is the current incumbent for the 35th District:
http://www.misenategop.com/senators/Booher.asp?District=35
108.207.63.130 (talk) 05:08, 6 March 2012 (UTC)
replies: text: Done! --Bejnar (talk) 16:49, 4 July 2014 (UTC)
thread_title: Office Period

message: This article relies too heavily on her Senate biography (now archived) prepared by her office and published by the Senate Republicans. This is not an independent source.  Additionally it shades the truth when its "facts" are compared to those same facts as reported in The New York Times.  Two examples: Her senate bio says over half-a-million signatures, while the NYT reports approx. 400,000 signatures.  The bio says "overturned the Governor's veto", when in fact the governor was bypassed by using a different process, initiative. No veto was overurned. See the NYT article. Based upon these imperfections in the source, it would be appropriate to replace citations to the Senate bio with those from independent reliable sources. --Bejnar (talk) 16:48, 4 July 2014 (UTC)
thread_title:  Over-reliance on one non-independent source 
Talk:Linear epitope

message: From the 2nd paragraph of the intro: "The linear sequence of amino acids that compose a protein is called its primary structure, which does not exist in nature".  I'm pretty sure what the editor meant to write was that 'the primary structure [of a fully-formed, native protein] is not presented to antibodies as such...'.  I'm not sure if that's what they meant, but either way, two objections:
1) Unless I'm mistaken, there are instances (in general, for normal protein interactions) were the primary structure (at least parts of it) DO exist in nature, meaning that uninterrupted stretches of primary sequence are part of the exposed outer architecture of a protein.
2) At the very least, can we rephrase the "does not exist in nature" to be less absolute, or at least be less suggestive to mean that the primary structure is some imaginary thing?  Maybe I'm being too literal, but certainly the primary structure exists as proteins form, before they are folded, and even after: even if its a tangled knot, one does not say the string itself doesn't exist, right?23.24.214.46 (talk) 00:48, 21 November 2017 (UTC)
Talk:Beta-2 microglobulin

message: Beta2microglobulin is used to stage multiple myeloma, so recently diagnosed multiple myeloma patients coming across the statement that for levels > 4 mg/L median survival is "only 12 months" get quite a shock. I certainly did. The reference given is dated 2011, and while it may be historically accurate, I believe this number is significantly out of date due to big advances in treatment of multiple myeloma in the last decade.
I'm an engineer not a doctor so I can't give another reference, but 12 month median survival doesn't correspond to lifetimes I see widely quoted in the literature, nor with the expected survival time I was given by two doctors (several years), nor with my experience, and my beta2microglobulin at diagnosis was 6.9 mg/L, significantly higher than the 4 mg/L threshold.      — Preceding unsigned comment added by 98.217.200.163 (talk) 16:13, 2 October 2015 (UTC)
thread_title:  Isn't 12 month median survival for multiple myeloma out of date? 

message: This article might be useful in an encyclopedia directed to medical and/or biological professionals.  Without further explanations of its jargon it is useless to non-specialists. I came here from the article on multiple myloma, which I had gone to because I wanted to learn more about the disease afflicing a good friend.  So far, the only thing I have learned is that doctors don't want to talk to non-MDs, but I knew that already. 
So, it's mainly a waste of bandwidth - just static.   Too Old (talk) 06:18, 10 June 2008 (UTC)
thread_title:  Over-Specialized 

message: According to FL stats serum levels of it is one of the 5 factors or parameters in the FLIP2 criteria. What is the upper limit of normal ? - Rod57 (talk) 17:31, 8 April 2016 (UTC)
thread_title:  Also a prognostic factor for follicular lymphoma 

message: Numerous times it mentions 'levels'. - It should clarify if this refers to concentration in blood serum or something else ? - Rod57 (talk) 17:41, 8 April 2016 (UTC)
thread_title:  Clarify if levels refers to levels in blood serum  

message: says "the B2M mutation was found in 6 to 8 percent of lung cancers. Importantly, the B2M mutation was found to be associated with the loss of the HLA-I complex, which is required for immunosurveillance." - Could mention if get RS ? - Rod57 (talk) 15:37, 25 January 2017 (UTC)
thread_title:  Mutations of B2M found in lung cancer 

message: In connection to the "citation needed" parts, this publication shows that loss of b2m leads to immune evasion: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.28338 46.189.36.164 (talk) 20:01, 21 September 2019 (UTC)
thread_title:  Loss of b2m leads to immune evasion 

message: Agtpwp 2409:4063:6C1B:FE74:831F:ABCD:DADB:E5A0 (talk) 04:17, 2 April 2022 (UTC)
thread_title:  JgwttJgAgj
Talk:X-linked severe combined immunodeficiency

message: This article could easily make C-class status with the addition of a very few inline refs.  WhatamIdoing (talk) 21:18, 13 March 2009 (UTC)
thread_title: Refs

message: I just moved X-SCID and its talk page to here, and am preserving the original talk page text below. --David Iberri (talk) 23:03, 8 May 2009 (UTC)
thread_title: Before X-SCID was moved here

message: Edited this section as it only talked about the IL-2 receptor and ignored the other Interleukin receptors that the common gamma chain is involved in, and help contribute to the disease.Philman132 (talk) 14:02, 20 May 2009 (UTC)
thread_title:  Molecular Biology 

message: I changed "acydovir" to "acyclovir" because I assumed it was a typo.
I changed "Although over 10 children have now been cured almost completely of X-SCID, four of the children have gone on to develop leukemia probably as a direct result of the therapy." to "In one particular trial, 10 children were treated at infancy for X-SCID. Nine of the 10 were cured of X-SCID. However, within two years of treatment, two of the children developed T-cell leukemia due to insertion of the IL2RG-containing virus near LMO2 (a known oncogene). A third child of the 10 developed leukemia within two years of that study being published, probably as a direct result of the therapy."
I went ahead and referenced the scholarly article that the news article referred to. There were only 3 children who had developed cancer. I'm not sure why the previous editor wrote four.
Hopefully my English was alright throughout all of that.  — Preceding unsigned comment added by Sakdsfhsl (talk • contribs) 09:36, 27 March 2012 (UTC)
replies: text: I remember there being a British trial and a French trial which caused Leukaemia. In one trial one child developed cancer and in the other three children did, if I remember correctly. That's where the confusion probably came from. However, I don't have the references to hand at the moment to add them in. 94.12.82.85 (talk) 15:50, 16 April 2012 (UTC)
thread_title:  Treatment 

message: "Gene therapy is also available to replace the mutant allele."
It's been tested, but it's not exactly routine. Perhaps rewording would be a good idea? 128.243.253.101 (talk) 17:03, 29 February 2012 (UTC)
thread_title:  Gene therapy available? 

message: xq13.1 is the location of the gene. The gene itself is IL2RG. 94.14.166.194 (talk) 17:14, 9 March 2012 (UTC)
thread_title:  xq13.1 gene? 
Talk:FCER1

message: I reverted the merging of FCER1A with this article for the following reasons:
* Logically, if we merge FCER1A, we would also need to merge MS4A2 into this article.
* Both FCER1A and MS4A2 contain  templates.
* Including two  templates plus one  template in the same article would produce an excessively long article page. (At some point in the future a GNF_Protein_box template for  may also be produced which would make the problem even worse.)
* There are automatic mechanisms for updating GNF_Protein_box content which assume there is only one template per article.  While I am not 100% sure, I believe the automatic update mechanism would break if there are two GNF_Protein_boxes in the same article.
* In contrast with GNF_Protein_box templates, the protein templates are relatively short so that three can be included in the same article without overwhelming the rest of the content.  In addition, the protein templates  provide clear links to the individual gene articles.
* While the individual gene/protein articles do not yet contain a lot of detail, they could in the future include specific information (e.g., mutations, SNPs, disease linkage, etc.) which would be unique to each gene.
Cheers. Boghog2 (talk) 10:20, 28 February 2009 (UTC)
thread_title:  Explanation reverted merge
Talk:Pantomime dame

message: Is the comment about Dames often being played by actors "well-known for their homosexuality" either relevant or correct? Is the article trying to say the Dame is the preserve of gay actors? (Trevek (talk) 08:01, 29 February 2008 (UTC)
replies: text: This section is poorly written and not at all accurate. There are many heterosexual Dames in pantomimes, this is just stereotyping. I'm going to change this a bit, since only 4 of the linked notable actors on the list state that they are gay.KlickingKarl (talk) 21:12, 6 February 2009 (UTC)
thread_title: noob?
Talk:Antigenic variation

message: I can find no evidence that the categories of antigenic variation listed under viruses (antigenic drift, shift, rift lift, sift, and gift) are called by these names anywhere but here. Does anyone know where this comes from? Logophile59 (talk) 21:05, 12 May 2019 (UTC)
thread_title:  drift, shift, rift, etc 

message: "Antigenic variation" sounds very generic but this term actually is used with a narrow meaning, referring to mutation systems with specific mechanisms that result in enhanced antigenic variability.  Thus it is applied to Trypanosomes, Plasmodium, and Borrelia, for instance, which have elaborate shuffling schemes.  But simply having a high genomic mutation rate is not called "antigenic variaton" in the literature. 
The more general term is "immune evasion" or "immune escape."  When a microbe masks its outer surface, this is a strategy of immune evasion but not a case of antigenic variation.  
So, the current version of this article starts out with antigenic variation, but then diverges into the more general topic of immune evasion.  
Some useful references: 
* Wisniewski-Dye F, Vial L. 2008. Phase and antigenic variation mediated by genome modifications. Antonie Van Leeuwenhoek 94:493-515.
* van der Woude MW, Baumler AJ. 2004. Phase and antigenic variation in bacteria. Clin Microbiol Rev 17:581-611, table of contents.
* Palmer GH, Bankhead T, Seifert HS. 2016. Antigenic Variation in Bacterial Pathogens. Microbiol Spectr 4.
* Horn D. 2014. Antigenic variation in African trypanosomes. Mol Biochem Parasitol 195:123-129.
* Barry JD, Hall JP, Plenderleith L. 2012. Genome hyperevolution and the success of a parasite. Ann N Y Acad Sci 1267:11-17.  
I will try to improve this at a later date, or find someone else to do it. Dabs (talk) 17:18, 29 August 2019 (UTC)
thread_title:  Remove immune evasion topics that are not in the category of antigenic variation
Talk:Papi (The L Word character)

message: AfterEllen points out that "Eva Torres" is the reason Carmen didn't go to her prom. This can't be coincidence; I think it should be mentioned somewhere in the article. ~ Wapiko 06:33, 27 March 2007 (UTC)
thread_title:  Papi's mention in the third season 

message: The Papi page should be restored. It has more information on the character than the merged article.
http://en.wikipedia.org/w/index.php?title=Papi_(The_L_Word_character)&redirect=no
174.22.13.18 (talk) 06:32, 18 September 2014 (UTC)
thread_title:  Papi
Talk:Microfold cell

message: I will be working on editing and updating this article as part of an undergraduate level Immunology class assignment. 
The section of the Microfold cell article I am most interested in the development section, which happens to also be the section with the least information. I would like to fill this section with information regarding what we know about the development of these cells, but with some context or reference to the research or experimentation used to arrive at these conclusions. I am also hoping to create a figure or adapt a figure from a recent review article so that we have some visualization about the position, location, and thus function of these cells. I am welcome to any feedback or collaboration! 
Today, I have drafted a new lead section that incorporates the summary of the proposed changes I have to the development section. I have also summarized some information from other sections of the article that is also reflected in the lead section. Here is a draft of my updated lead section:
Microfold cells (or M cells) are found in the follicle-associated epithelium of the Peyer's patch as well as in bronchus-associated lymphoid tissue (BALT). They transport organisms and particles from the gut lumen to immune cells across the epithelial barrier, and thus are important in stimulating mucosal immunity. Many pathogens including Shigella flexneri, Salmonella typhimurium, and Yersinia pseudotuberculosis, and prions in Bovine spongiform encephalitis enter the gut through the exploitation of M cells. M cells differentiate and mature when they receive signals from the Peyer's patch and these molecular identities of these signals are yet to be uncovered.
Unlike their neighbouring cells, they have the unique ability to take up antigen from the lumen of the small intestine via endocytosis or phagocytosis, and then deliver it via transcytosis to dendritic cells (an antigen presenting cell) and lymphocytes (namely T cells) located in a unique pocket-like structure on their basolateral side.[citation needed]
Immcarl17 (talk) 23:12, 8 February 2016 (UTC)
thread_title: Untitled

message: The first paragraph is poorly worded and confusing. In particular "These cells" should be explicitly identified. What cells? --Ben Best:Talk 14:09, 19 April 2021 (UTC)
thread_title:  First paragraph
Talk:Monoblast

message: This diagram does not clearly separate the common myeloid and common lymphoid lineages of haematopoiesis. This is an important distinction that I feel is important to draw attention to. For instance, in this diagram, it appears to show that platelets and monocytes are more closely related to the lymphocytes and natural killer cells than they are to erythrocytes and granulocytes, which is not the case.  — Preceding unsigned comment added by DocLovely (talk • contribs) 09:26, 1 October 2020 (UTC)
thread_title:  Blood Cell Lineage Diagram
Talk:Immune-mediated disease

message: Just a question,if you don't mind.  is there only one subset with Immune-mediated diseases? I looked up the word subset,but maybe i am not understanding it correctly. Thank You.50.80.57.145 (talk) 04:50, 3 December 2012 (UTC)
replies: text: I don't understand the question.  One subset of what?  WhatamIdoing (talk) 22:04, 6 December 2012 (UTC)
thread_title: Just
Talk:MHC restriction

message: Hi, i will be working on this article and here are some sources I will be using. Please feel free to offer you suggestions! Thank you. :)
** Baker, B. M., et al. "T Cell Receptor Specificity, Cross-Reactivity, and MHC Restriction are Inextricably Linked and Result from Cooperative Engagement of the Composite Peptide/MHC Surface." Biophysical Journal 104(2): 403a.Bjorkman, P. J. (1997). "MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions." Cell 89(2): 167-170.Van Laethem, F., et al. (2012). "MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection."Zinkernagel, R. M. and P. C. Doherty (1997). "The discovery of MHC restriction." Immunology Today 18(1): 14-17.
Immcarle8 (talk) 07:53, 30 January 2016 (UTC)
thread_title: Untitled

message: Hi, I am an Immunology student and i just added body sections to the article page. Please let me know if you have any views or suggestions! I will really appreciate your input. :)
Immcarle8 (talk) 06:30, 15 February 2016 (UTC)
thread_title:  Body section
Talk:Serostatus

message: can you say why you felt this concept should be separate from seroconversion? It seems to me that there are two closely related concepts here which are almost the same, and not much content to differentiate the articles. Which sources are used in either of these articles do you think would be inappropriate for using in discussing the other concept? Previously, serostatus was a redirect to seroconversion, but you wanted to WP:FORK the articles. Why?  Blue Rasberry (talk) 00:24, 6 March 2015 (UTC)
replies: text: The increasing recognition of seronegative autoimmune diseases, along with improving technology that continues to identify new antibodies, has made serostatus a unique area of research. Seroconversion describes the process of getting a disease, not the state of being seronegative or seropositive. This article is about those states, not that process. All of this article's references are uniquely about serostatus and not seroconversion.Nocowardsoulismine (talk) 01:50, 6 March 2015 (UTC)
thread_title:  Was redirect, now own article
Talk:Mimotope

message: Contribution that does not really fit "When antibodies do not follow the protein background, the epitope's characterisation by a subsequence of the target protein is not possible. A synthetic oligopeptide mimicking the binding, or a series of these, then substitutes the original protein to work towards a molecular model of the binding." Anybody feeling stimulated to improve?
 Smoe (talk) 11:35, 16 April 2010 (UTC)
thread_title: Untitled

message: In the next few weeks I will be adding information and reorganizing this Wikipedia page. Here is a list of several sources (reviews) I intend to use:
: 1. Favoino E, Prete M, Marzullo A, Millo E, Shoenfeld Y, Perosa F. CD20-Mimotope Peptide Active Immunotherapy in Systemic Lupus Erythematosus and a Reappraisal of Vaccination Strategies in Rheumatic Diseases. Clin Rev Allergy Immunol. 2017;52(2):217-233. doi:10.1007/s12016-016-8551-x
: 2. Huang J, He B, Zhou P. Mimotope-based prediction of B-cell epitopes. Methods Mol Biol. 2014;1184:237-243. doi:10.1007/978-1-4939-1115-8_13
: 3. Slansky JE, Nakayama M. Peptide mimotopes alter T cell function in cancer and autoimmunity. Semin Immunol. 2020;47:101395. doi:10.1016/j.smim.2020.101395
: 4. Luzar J, Štrukelj B, Lunder M. Phage display peptide libraries in molecular allergology: from epitope mapping to mimotope-based immunotherapy. Allergy. 2016;71(11):1526-1532. doi:10.1111/all.12965
: 5. Zhang D, Chen Y, Fan D. MG7 mimotope-based DNA vaccination for gastric cancer. Expert Rev Vaccines. 2006;5(2):223-231. doi:10.1586/14760584.5.2.223
--Immcarle148 (talk) 01:46, 29 January 2021 (UTC)
thread_title:  Will be Updating this Site
Talk:Wigram

message: I'm afraid the fair use images will have to go. Those images all fail criterion #1 (relevant bit highlighted): "No free equivalent. Non-free content is used only where no free equivalent is available, or could be created, that would serve the same encyclopedic purpose." You could just go there and take the photo yourself, hence it's obviously outside the rules. As for the photos taken by drone, well, you could do that, too. Wikipedia's most famous example on how strict the rules are is Kim Jong-un, a head of state for whom Wikipedia had no photo for years. Of course, you couldn't just rock up in North Korea and shove a camera into the man's face. But the same issue still applied; you could theoretically create that photo and hence it's not fair use. Schwede66 21:08, 20 June 2021 (UTC)
thread_title:  Fair use images 

message: Please have a read of MOS:DATEFORMAT. Schwede66 10:13, 22 June 2021 (UTC)
replies: text: Thanks for the advice Schwede66 I have had a read and now know for next time. StraightTalkNZ (talk) 10:53, 22 June 2021 (UTC)
thread_title:  Date format
Talk:Wairoa

message: Please delete "Wairoa is a Mongrel Mob gang stronghold." because this is not true at all! Refer www.wairoadc.govt.nz
Yroaynot2011 (talk) 10:35, 27 September 2011 (UTC)
replies: text: As this appears to be the reason the page was locked in the first place there needs to be more discussion about this here on the talk page.  --Jnorton7558 (talk) 13:56, 27 September 2011 (UTC)

text: The page you mention contains a media release on its front page: "Enquiries will be made into the gang situation in Wairoa", and the detail quotes the mayor as saying "“I explained that the situation with the gangs in Wairoa had reached a crisis point". See . This does not support your statement that Wairoa is not a Mongrel Mob gang stronghold, unless you are claiming that it is more influenced by a different gang. However, recent media reports such as  indicate that the Mongrel Mob is still active in the town.-gadfium 21:04, 27 September 2011 (UTC)
thread_title:  Edit request from Yroaynot2011, 27 September 2011
Talk:Twizel

message: Any information about the origin of the name Twizel?  —Preceding unsigned comment added by 82.39.91.9 (talk) 11:23, 7 August 2009 (UTC)
replies: text: according to this book it was named after the bridge/area near Twizell Castle ( possibly indirectly after the Twizel River ). Not sure if this ref is good enough to include in article. - SimonLyall (talk) 11:25, 10 August 2009 (UTC)
replies: text: Indeed, now have a good ref. - Snori (talk) 04:59, 22 July 2017 (UTC)
thread_title: Name

message: Is there any evidence for the claim that the town was intended to be temporary? Some statements are unlikely, for instance few telephone lines were underground in the 1960's. Also, was there a fight to "save the town itself" in 1983 - I don't recall this.Royalcourtier (talk) 10:17, 14 June 2017 (UTC)
replies: text: Absolutly; did you not read http://www.odt.co.nz/lifestyle/magazine/283500/town-saved-bulldozers ? Snori (talk) 04:57, 22 July 2017 (UTC)
thread_title:  Temporary town? 

message: Hi, I've just reverted the 'fact' of Ruataniwha being the Māori name for Twizel. It might seems logical that it would be, (i.e Ruataniwha Station, and Lake) but I don't believe it is, or every has been, applied to Twizel itself. If you know otherwise, of course feel free to pop it back, along with a ref to Reputable Source. - Snori (talk) 04:57, 22 July 2017 (UTC)
thread_title: Māori name