lflage/wiki-talks huggingface dataset:
Talk:Phospholipid scramblase

message: Article says: "PLSCR3 has been proposed to be involved in this translocation from the inner to the outer membrane that is essential for maintaining the mitochondrial architecture, mass, and transmembrane potential." This needs, at a minimum, a citation, but more important would be a plausible mechanism by which translocating a phospholipid from the inner to the outer membrane could possibly alter or maintain the potential across the inner membrane. Rdphair (talk) 06:21, 13 September 2012 (UTC)
replies: text: You can add a citation needed template to highlight this issue.  Please edit the article and add the  tag after the assertion you are questioning. Alexbateman (talk) 11:22, 14 September 2012 (UTC)
thread_title: Untitled

message: This protein doesn't catalyze a reaction. Isn't it more of a channel/transporter than an enzyme, as it is described in the intro?  — Preceding unsigned comment added by 142.157.54.26 (talk) 21:55, 21 October 2012 (UTC)
thread_title:  Enzyme?
Talk:Antiporter

message: A list of examples would be interesting, and whether antiporters are less common than symporters/cotransporters - if this is known.  — Preceding unsigned comment added by Jimw338 (talk • contribs) 04:02, 1 March 2012 (UTC)
thread_title:  Examples? 

message: — Assignment last updated by Nsopala (talk) 01:57, 15 February 2024 (UTC)
thread_title: Wiki Education assignment: BIOL 4610H_6610 Cell Biology
Talk:Catalans Dragons

message: Someone check the wiki link - I suspect it's been directed to the wrong player entirely.--Koncorde 10:45, 26 August 2007 (UTC)
thread_title: Justin Murphy
Talk:Lady Washington

message: The photo says it was taken in 1988, but the replica Lady Washington wasn't built until 1989.  Huh?  —Preceding unsigned comment added by Justi521 (talk • contribs) 18:01, 9 July 2008 (UTC)
replies: text: Sources I've been able to find say she was built "in time for the 1989 centennial."  It's possible she was launched in 1988. -- Brianhe (talk) 22:28, 20 May 2009 (UTC)
replies: text:  All the photos currently in use are from 2008 - one by User:Miso Beno from July 2008 from shore looking at her, and the gallery I took in November 2008 from aboard the ship.  Georgewilliamherbert (talk) 08:05, 21 May 2009 (UTC)
thread_title:  Image 

message: The Lady had a run-in with the Union Pacific Bridge in Pasco in the 90s that broke a mast or two.  There's a song and some articles that I'm unable to locate.  Such information would be relevant to the current Lady Washington. 130.20.71.48 (talk) 17:08, 26 October 2009 (UTC)
replies: text: https://archive.seattletimes.com/archive/?date=19911018&slug=1311762 Wcroth55 (talk) 16:15, 2 June 2023 (UTC)
thread_title: Pasco Union Pacific Railroad Bridge Event?

message: There's enormous confusion all over the web (including Wikipedia) regarding the difference between a brig, a brigantine, and a snow. The root of this confusion is that, like the words "chips" and "pants", the terms "brig" and "brigantine" mean different things depending on if you're using US or UK terminology. A brig(US) could be the same thing as a brigantine(UK), and a brigantine(US) is a hermaphrodite-brig(UK). Further complicating matters is that many people lump the snow in with the brig due to similar appearance. I've added a short clarification paragraph to help people understand what the Lady Washington actually is. See the brig, brigantine, and sail plan pages for more info.  — Preceding unsigned comment added by 72.74.34.8 (talk) 18:43, 29 October 2016 (UTC)
thread_title:  "Brig" vs "Brig" vs "Brigantine" vs "Brigantine" vs "Snow" 
Talk:Urate oxidase

message: "It has also been proposed[who?] that the loss of this UO protein expression has been advantageous to hominids, since uric acid is a powerful antioxidant and scavenger of singlet oxygen and radicals. Its presence provides the body with protection from oxidative damage, thus prolonging life and decreasing age-specific cancer rates."
How is that advantageous?  —Preceding unsigned comment added by 142.167.120.225 (talk) 17:34, 20 July 2009 (UTC)
replies: text: However, this is highly unlikely as proteins are capable of being activated only when concentrations exceed a certain amount. Huh? What is highly unlikely? Which proteins? Concentrations of what? This sentence doesn't make any sense. --Rhombus (talk) 13:01, 14 September 2013 (UTC)
thread_title: Relevance in humans

message: I believe that the 5-hydroxyisourate picture in the metabolic pathway at the beginning of the article (Uric acid to 5-hydroxyisourate to allantoin) should be mirrored. Both the uric acid and the allantoin are facing one way but the intermediate metabolite, the 5-hydroxyisourate is facing the other way.
I know there is not scientific relevance whatsoever in displaying the image one way or the other, but it but be much more intuitive and easier to follow/memorize this metabolic pathway if all the images share the most possible visual resemblance.
Diego  — Preceding unsigned comment added by Diego Dabrio (talk • contribs) 07:42, 8 April 2013 (UTC)
thread_title:  5-hydroxyisourate mirror image 

message: This article says: "It was lost in early primate evolution,[3] and so is absent in humans and other higher apes." "Early" doesn't seem right. If it was absent in all simians (monkeys and apes) as well as tarsiers, but present in lemurs and lorises, then "early" would make sense. In this case, something like "recent" would be more accurate. Zyxwv99 (talk) 23:43, 6 May 2016 (UTC)
thread_title:  Early primates?
Talk:CYP2E1

message: In the table, diethyldithiocarbamate and disulfiram are listed as inhibitors.  Disulfiram does not appear to be described as an inhibitor of CYP2E1 in the reference supplied, and, in the reference for diethyldithiocarbamate, yes, it is listed in a table as an inhibitor, but this isn't backed up by any further information or reference there.
Disulfiram is a disabler of the enzyme aldehyde dehydrogenase, and, as such, has been used in "treatment" of alcoholism; diethyldithiocarbamate is a precursor of disulfiram.
I suspect that these two chemicals may have been listed in this article in error, because they are related to alcohol over-consumption, being inhibitors of a different important enzyme involved in alcohol metabolism. 
Inhibitors of CYP2E1 (if any are known) would indeed be important, as it is the action of this induced enzyme that is responsible for some hepatic damage especially in heavy drinkers.
120.18.159.225 (talk) 07:26, 25 October 2013 (UTC)
thread_title: inhibitors

message: This paragraph seems to contradict itself:
:This important enzyme has allowed for the North Americans of Europe to have demonstrably higher alcohol tolerance than their First Nations counterpart. The result of evolution has allowed for a decreased likelihood of developing alcoholism due to their increased exposure to alcohol. Evolution has allowed higher levels of alcohol dehydrogenase in their bodies. CYP2EI regulates how fast people get drunk. People with the gene (10-20% of the Canadian population) are likely to get drunk after only a few drinks – this low tolerance appears to protect them from becoming alcoholics.[3]
If I read this correctly, at first it claims alcoholism is less likely due to higher tolerance leading to greater exposure and hence fewer alcoholics. yet, the ending sentence claims the inability to tolerate alcohol leads to fewer alcoholics due to less exposure. In short, it seems to argue two completely contradictory points. Not to mention that it starts by saying the enzyme allows for greater tolerance, but then starts to refer to "this gene" (without specifying the gene) and reduced tolerance. I assume the gene mentioned is one that prevents the expression of the enzyme, but as it is written this is a supremely confusing and contradictory paragraph.
It is not related to this issue, but there is also a problem with the description "North Americans of Europe", which suggests individuals who migrated from North America to Europe and now reside there, while the reference to Canadians suggests the writer meant "North Americans of European descent" or something similar. I will correct this, though I don't know how to correct the bigger issue, as I have not read the cited article and cannot say whether alcoholism is prevented by increased or decreased tolerance, so can't say which of the two mutually exclusive argument which the paragraph puts forth is correct. 76.111.27.52 (talk) 12:09, 29 May 2015 (UTC)
thread_title: Contradiction
Talk:Jiangmen

message: That whole section seems dubious, far too long with far too many suspect entries. Is it meant to be people born here, or just people who have been here? If the former then many probably don't belong – the Americans for example. If the latter then it’s trivia, not enough to establish a link. Many people have visited, even lived here for a short time, but have no particular association. It's unsourced and is missing all but two links (which is our normal way of establishing notability, having articles to link to). It probably should be removed, unless someone wants to sort it out.--JohnBlackburnewordsdeeds 02:00, 9 May 2015 (UTC)
thread_title:  Notable people? 
Talk:Ornithine transcarbamylase

message: Which one is right: -mylase or -moylase ? Many articles spells out carbamoyl such as carbamoyl phosphate except ornithine transcarbamylase deficiency. --Octra Bond (talk) 06:45, 24 June 2011 (UTC)
thread_title:  Name? 

message: Perhaps the title of this section should be changed, content should be added, or the reaction mechanism gif should be elsewhere. Vokesk (talk) 23:39, 11 December 2014 (UTC)
thread_title:  Function
Talk:Fructose 1,6-bisphosphate

message: I think there needs to be a WP:CHEM statement on sugar representations. Also, protonation states ESPECIALLY if InChIKeys are going to be generated…
RNBGYGVWRKECFJ-CERMHHMHBJ is for the charged structure 
RNBGYGVWRKECFJ-GSMOWLIGBO is for the structure in the ChemBox
--ChemSpiderMan (talk) 04:15, 13 January 2008 (UTC)
thread_title:  Charged vs uncharged and linear versus cyclized
Talk:Fructose 2,6-bisphosphate

message: I am by no means an expert and could be dead wrong, but I believe that the most simple definition of fructose 2,6-bisphosphate would have it acting on phosphofructokinase-2 and fructose 2,6-bisphosphatase rather than FBPase-1 and PFK-1.  Lehninger Principles of Biochemistry 5th ed. Nelson, D and Cox, M. W.H. Freeman and Co. New York, NY. 2008 p. 588
Signstomes (talk) 05:25, 17 December 2008 (UTC)
thread_title:  F26BP acts on PFK-2 and FBPase-2.  PFK-1 and FBPase-1 are acted on by fructose 1,6-bisphosphate. 
Talk:Separase

message: Please see this paper which says, " Anaphase is triggered when separase cleaves the Scc1 subunit of cohesin at two specific recognition sequences." It seems that genetics textbooks are actually incorrect. 134.241.58.181 (talk) 20:47, 4 February 2014 (UTC)
thread_title:  Separase during Anaphase, not Metaphase
Talk:Matrix metalloproteinase

message: MMP-8 is also known as collagenase-2. 
Source: https://www.jci.org/articles/view/119316/version/1/pdf/render 
Tristyn⌘ 18:12, 22 June 2016 (UTC)
thread_title: Untitled
Talk:Tich Freeman

message: The article says his name comes from his short stature, but what does 'tich' means?  — Preceding unsigned comment added by 2601:1C0:8600:4390:782F:9C4A:2237:D9C9 (talk) 14:24, 14 November 2021 (UTC)
replies: text: If you're short (or a child perhaps) you're called "tich". I don't know why off the top of my head, but you are. I'll look into it... Blue Square Thing (talk) 14:32, 14 November 2021 (UTC)
thread_title: Untitled
Talk:Lincoln High School (New Jersey)

message: There is nearly enough here for a "start" article, but we would expect more topis. Use of refs is excellent. Any pics? Victuallers 17:19, 26 April 2007 (UTC)
thread_title: Comments
Talk:CTP synthetase

message: Should be moved to CTP synthetase - and this page made a redirect Hichris (talk) 20:23, 18 November 2008 (UTC)
replies: text: Agreed, as it does hydrolyze ATP. I'll move it. P. D. Cook Talk to me! 16:45, 31 January 2013 (UTC)
thread_title: Untitled
Talk:Pyruvate carboxylase

message: "Pyruvate carboxylase was first discovered in 1959 by M. F. Utter and D. B. Keech." I thought Carl Neuberg was the first to discover pyruvate carboxylase in the 1910s? Carstensen (talk) 21:25, 20 September 2011 (UTC)
thread_title: Untitled
Talk:Fixation (histology)

message: All chemical fixation techniques for histology introduce artifacts.  Medical facilities often strictly control processing techniques (or they're set by governing bodies) to account for this.  Good references can probably be found.  A more recent reference on mesosomes was added.  --69.226.108.255 (talk) 03:04, 8 March 2008 (UTC)
thread_title:  Fixation and artifacts 

message: I came across the article Heat fixation, and I think its info should be moved here. It would fit nicely under the Types of fixation section, in my opinion. raven1977 (talk) 14:52, 5 October 2008 (UTC)
thread_title: Merger proposal

message: There are no references provided for the "Factors Affecting Fixation" section (i.e. appropriate pH, responsibility of underfixation for inappropriate results in some assays). There are actually very few references for the article in general, so it would be helpful to add more sources.
Rawkergirl (talk) 19:14, 4 November 2010 (UTC)
thread_title:  References 

message: For article Karnovsky fixative, I added into a "See also" section. If any expert who is more knowledgeable of this topic would like to move to another spot in Fixation article, please do so. This subject is 100-percent out of my wheelhouse. Thanks. JoeNMLC (talk) 00:31, 16 December 2021 (UTC)
thread_title:  Karnovsky fixative
Talk:Troponin T

message: It is remarkable and disturbing that there is no entry in Wikipedia English for Hugo A. Katus, whose contributions are important and widely utilized. Nicmart (talk) 19:23, 28 July 2018 (UTC)
thread_title:  Hugo Katus 

message: TnT currently redirects here, but the article is not mentioned at TNT (disambiguation). I would fix that, but the lack of context in the introduction means that I don't understand what this actually is anywhere near well enough to write a useful entry. Thryduulf (talk) 20:47, 27 January 2019 (UTC)
thread_title:  Context, TnT
Talk:Heterotrimeric G protein

message: If there are no objections, I would merge content of this page to G protein and make this page redirect. Biophys (talk) 16:27, 17 June 2011 (UTC)
thread_title: Merger Proposal

message: Gustducin has been shown to act through a  GPCR-Gq/Gβγ-IP3 pathway and a GPCRGs-cAMP pathway (promoting the activity of adenylyl cyclase) in taste transduction.
See here: Gustducin#Gustducin_and_its_second_messengers
There is also some information here: Gustducin#Comparisons_with_transducin
"Similarly, α-gustducin binds the inhibitory units subunits of taste cell camp PDE which also causes a decrease in cAMP levels."
Not sure how we can elucidate all this information.  — Preceding unsigned comment added by HeavyQuark (talk • contribs) 19:54, 11 December 2012 (UTC)
thread_title:  Gustducin 

message: The information shown here about the 4 G protein families is correct. However the pages that show up when you click a link that should lead to a wiki page about the family, they are about only some of the G proteins and not about all family members. For example the page for Gi does not include subunits t1-3 and z. The only page that does include all family members is Gq. 
I think that maybe these pages should be renamed (e.g. Gq alpha subunit → Gq/11 alpha family) and should include all members.
Instability (talk) 15:24, 20 July 2017 (UTC)
thread_title:  G protein families pages 

message: In the image, described as
"This heterotrimeric G protein is illustrated with its theoretical lipid anchors. GDP is black. Alpha chain is yellow. Beta and gamma chains are blue."
The black part is not immediately seen. I'd modify to 
    "GDP is black, wrapped in the yellow alpha chain, at the bottom right side of the picture"
and I'd say at the beginning what is the grey part (because is bigger, that's why I'd say it as first thing), but I don't know what it is so I can't write it.
What do you think? 😃  — Preceding unsigned comment added by 131.181.167.16 (talk) 06:26, 24 February 2020 (UTC)
thread_title:  Image description 

message: "G proteins are made up of alpha (α), beta (β) and gamma (γ) subunits."
This neglects that some G proteins only have subunit.
CaffeineWitcher (talk) 06:58, 9 May 2020 (UTC)
thread_title: sentence incorrect
Talk:Prelamin-A/C

message: I support the proposed merge. --Arcadian (talk) 15:20, 6 February 2008 (UTC)
thread_title:  Proposed Merge 

message: BogHog, thanks for help and Happy New Year, but in Opera 10.10 there is now a huge hiatus below the text and above the image. Best regards, --CopperKettle 12:56, 3 January 2010 (UTC)
replies: text: Likewise  CK, Happy New Year!  i have now moved the figure down which at least reduces the size of the gap.  Unfortunately there does not seem to be an ideal solution.  From a logical standpoint, the figure belongs between the (normal) function and (ab normal) clinical significance section, but as you point out, this produces an large gap (also in Safari and I would assume most other web browsers).  Removing the  template from the article completely removes the gap, but then causes the references to be sandwiched between the graphic and the protein box which looks ugly.  I think the present version is the best compromise that minimizes both the size of the gap and the distance between the figure you just added and the text in the article that is related to the figure.  I hope this is OK.  Of course, please feel free to tweak the formatting further.  Cheers.  Boghog (talk) 14:17, 3 January 2010 (UTC)
replies: text:  Thank you! Best regards, --CopperKettle 17:27, 3 January 2010 (UTC)
thread_title:  Image position 

message: Picture "Biogenesis ..." should be crop at the bottom. Additionally, it is low quality.  — Preceding unsigned comment added by 88.156.226.32 (talk) 19:06, 25 October 2014 (UTC)
thread_title:  Image Position and Quality 

message: I wish there was more explanation about the discovery and the structure of the LMNA gene, or even provide a further reading about it. — Preceding unsigned comment added by Nalharbi2016 (talk • contribs) 20:45, 8 September 2018 (UTC)
thread_title:  discovery and structure  

message: Something should be done to provide interwiki links to the same article in other languages, for instance, :ru:Ламин A/C. --CopperKettle (talk) 00:56, 20 July 2022 (UTC)
thread_title:  Interwiki
Talk:Ladder streets

message: Is it obvious where the name comes from,or should there be a better definition? Ohconfucius 13:19, 3 September 2007 (UTC)
replies: text: I think this article should remain. Even though it may not be notable to foreigners, it is definitely unique to the older parts of HK as well as to tourists. Having this article as a stub with perhaps a little more history into it would definitely make it notable. -Herenthere (Talk) 17:37, 23 March 2008 (UTC)
thread_title: Why?
Talk:Protocadherin

message: This page needs to be updated to reflect the recent announcement of Protocadherin gene families being identified in Cephalopods.  Currently, there are multiple references to mammals as well as vertebrates.  See http://www.nature.com/nature/journal/v524/n7564/full/nature14668.html for the Nature article that details this finding.  — Preceding unsigned comment added by 15.211.201.81 (talk) 16:53, 14 August 2015 (UTC)
thread_title:  Protocadherin gene families identified in Cephalopods
Talk:Fetuin

message: The introductory paragraph is self-contradictory, and contains no citations. The contradiction is between the statement that fetuin belongs to a group of carrier proteins which includes albumin, and the last sentence of the paragraph which contrasts fetuin abundance with albumin abundance in fetal versus adult bovine serum. The first paragraph is contradicted by the "Family members" section, which puts fetuins in the cystatin superfamily of proteins. But that section seems contradicted by the cystatin entry, which states that cystatins have a similarity to fetuins. -- Ben Best:Talk 15:01, 7 September 2018 (UTC)
thread_title:  Questionable introductory paragraph
Talk:Orders of magnitude (rotational speed)

message: The link http://lsro.epfl.ch/cfmd/ is broken.
:Well spotted, I've fixed the link, thanks. MarašmusïneTalk 07:43, 25 July 2007 (UTC)
thread_title:  Citation link broken 

message: Molecules can spin very fast, Gigahertz to Terahertz kind of rates, should we include these? Graeme Bartlett (talk) 00:29, 3 February 2015 (UTC)
thread_title: Molecules
Talk:Apolipoprotein AI

message: Is the spelling Apolipoprotein A1 (without hyphen) or Apolipoprotein A-1 (with hyphen) or Apolipoprotein A-I (Roman numeral)?
CielProfond (talk) 19:52, 4 November 2011 (UTC)
thread_title:  Spelling/Typography? 
Talk:Apolipoprotein A2

message: This seems to be a duplicate with APOA2 and should likely be merged with this one? Sebotic (talk) 07:43, 31 December 2015 (UTC)
thread_title:  Seems to be a duplicate 

message: No discussion space for merge - suggest straight redirect.--Iztwoz (talk) 11:09, 7 December 2021 (UTC)
replies: text: Klbrain (talk) 08:27, 18 April 2022 (UTC)
thread_title: Redirect
Talk:The D.A. (1971 TV series)

message: This is 2nd time this has happened to me, and I can't see the error.  
Notice the episode guide, the guest stars for the last two shows are not showing up and I formatted them the same as the others.  Can anyone see what I did wrong? 
I'm sure its a small, dumb thing that the boomer can't see, no matter how hard I try!
PB57 (talk) 13:33, 22 May 2020 (UTC)
replies: text: Special:Diff/958209267 – Majavah talk · edits 13:59, 22 May 2020 (UTC)
thread_title:  dumb question, but insanity looms with no reply
Talk:C5-convertase

message: Joszi et. al have discussed (and it seems more likely) that FHR-1 isn't necessary for preventing aHUS so much as it is for developing FH tolerance. 50% of Nigerians lacks FHR3 and FHR1. Also, 21/24 IgG from that paper that are anti-FH will bind FHR1. Thus, it's likely they protect in mechanisms distinct from "Anti C5-convertase activity".  — Preceding unsigned comment added by 129.96.87.45 (talk) 07:46, 6 February 2020 (UTC)
thread_title:  aHUS and FHR-1
Talk:Collagen, type III, alpha 1

message: There should not be a redirect to a gene from its product (to here from Collagen Type III http://en.wikipedia.org/w/index.php?title=Type_III_collagen&redirect=no)  —Preceding unsigned comment added by 81.154.180.123 (talk) 22:10, 5 January 2009 (UTC)
thread_title: Untitled

message: The image file should only include the chains that make up the collagen III proper, not the attached protein as well.  — Preceding unsigned comment added by 96.40.255.186 (talk) 00:40, 29 November 2011 (UTC)
thread_title:  Image
Talk:Fibrillogenesis

message: Hello! I'm Greek and I'm pretty certain that "fibrillo" is derived from Latin. "Genesis", on the other hand, is indeed utterly Greek! Please verify and correct it. Thanx! 155.207.86.164 08:43, 19 June 2007 (UTC)
replies: text: Noted and corrected --kupirijo (talk) 08:12, 3 October 2023 (UTC)
thread_title: Untitled