Talk:Lambert–Eaton myasthenic syndrome

message: added  to the opening words of the article. This is a review in Japanese, and from the abstract I can't see clearly whether there is any information in that article that definitely needs to be sourced from there and cannot be sourced to any of the other reviews already cited.
:The source confirms the disease acronym at first glance; it in no way distracts the reader, damages the article, nor negates the pending GA review; and the abstract is in english. Rcej (Robert) - talk 09:36, 23 February 2011 (UTC)
replies: text: So does Mareska's article, in English, in the abstract. To be honest, I found it a bit distracting. We don't usually provide sources for nomenclature in medical articles, unless the verifiability is doubtful or disputed. JFW | T@lk 21:40, 23 February 2011 (UTC)

text: This was vaguely useful, but I decided not to cite anything from section 4 ("compensatory mechanisms") because its findings don't seem to have applied to LEMS subjects. JFW | T@lk 23:46, 23 February 2011 (UTC)
thread_title:  More sources 

message: From the lead section, paragraph 2: "The diagnosis is usually confirmed with electromyography and blood tests; these also separate it from myasthenia gravis." From "Diagnosis", paragraph 2: "A similar pattern is witnessed in myasthenia gravis," in reference to CMAP. Does EMG distinguish LEMS from myasthenia gravis? Axl ¤ [Talk] 10:19, 14 March 2011 (UTC)
replies: text: Yes. The characteristic >200% increase in amplitude in exercise is what distinguishes LEMS from MG. Will make it better. JFW | T@lk 10:51, 14 March 2011 (UTC)
replies: text:  So the pattern is similar at rest? Exercise or a "rapid burst of stimuli" allows the distinction? What is "a rapid burst of stimuli" in this context? Axl ¤ [Talk] 09:26, 15 March 2011 (UTC)

text: The source is not very clear as to whether the pattern is similar at rest. Given that myasthaenia gravis is fatiguable, this may well be the case. I will need to verify this with another source (or with Pizzaman). The "rapid burst of stimuli" is as indicated between the brackets (10s of 20Hz electric stimuli). JFW | T@lk 23:36, 15 March 2011 (UTC)
replies: text:  The text does not indicate electrical stimuli. Axl ¤ [Talk] 09:31, 16 March 2011 (UTC)
replies: text:  I have added this. Axl ¤ [Talk] 09:33, 16 March 2011 (UTC)
thread_title:  LEMS vs myasthenia gravis 

message: The section "Signs and symptoms" contains several uses of the word "some" to describe the number of LEMS patients with a given symptom. Any chance of a table showing the percentage of patients who have those symptoms? Axl ¤ [Talk] 10:20, 22 March 2011 (UTC)
replies: text: The sources don't provide hard figures that could be used for this purpose. Mareksa only states 75% have orthostatic hypotension. Suggestions for synonyms of "some" are welcome. JFW | T@lk 20:31, 22 March 2011 (UTC)

text: A characteristic feature of LEMS, both clinically and myographically, is the augmentation of power by exercise. Therefore, reflexes are difficult to elicit at rest, while they may normalise after getting the patient to contract the affected muscles for a while. This is because the calcium channels eventually deliver the required amount of calcium, albeit more slowly, into the muscle after repeated stimulation. Suggestions for clarification would be welcomed. JFW | T@lk 20:31, 22 March 2011 (UTC)
replies: text:  How about "At rest, reflexes are typically reduced. With muscle use, reflex strength increases."? Axl ¤ [Talk] 09:20, 28 March 2011 (UTC)

text: What I meant was that those people with LEMS that have an underlying lung cancer are often asymptomatic otherwise. I will try to rephrase this. JFW | T@lk 20:31, 22 March 2011 (UTC)

text: In a sense, smoking causes LEMS by predisposing to SCLC, and this probably why Verschuuren mentions it so prominently. I have no problem with removing the sentence. JFW | T@lk 20:31, 22 March 2011 (UTC)

text: I have simply changed it to the term used by MESH. JFW | T@lk 20:31, 22 March 2011 (UTC)

text: LEMS and MG are very similar, being the two main acquired myasthenic syndromes. Verschuuren makes a number of observations about MG to allow a parallel or a constrast. I think we ought to say that both diseases have a similar immunological basis. I agree that the mention of thymoma is a bit off-topic. JFW | T@lk 20:31, 22 March 2011 (UTC)
thread_title:  Questions for JFW from Axl