Talk:Heparin

message: reference to slaughtered meat animals is redundant  —Preceding unsigned comment added by 72.248.115.194 (talk) 14:58, 20 February 2009 (UTC)
thread_title:  Meat 

message: I've never heard of heparin referred to by its trade name.  Perhaps delete the brand names?  Andrew73 19:33, 22 September 2005 (UTC)
replies: text: I deleted the brand names...they seem to clutter the article!  Andrew73 16:19, 30 October 2005 (UTC)
replies: text: This was probably a bad idea, trade names are always important when identifying drugs.  —Preceding unsigned comment added by Mrdeath5493 (talk • contribs) 06:58, 9 September 2009 (UTC)
thread_title:  Delete trade names 

message: On PubChem an image is available but it's not clear where the repeat moieties connect to. Perhaps a chemist may be able to help. JFW | T@lk 20:55, 28 December 2005 (UTC)
thread_title:  Image 

message: Please elaborate on fraxiparin, another medicine with function similar to heparin. Thanks borgx (talk) 04:13, 20 February 2006 (UTC)
replies: text: Fraxiparin is one of the low molecular weight heparins.  Andrew73 02:55, 23 February 2006 (UTC)
thread_title:  Fraxiparin 

message: Excellent figures and clear text. However, more references would be an improvement, particularly in the medical sections. TimVickers 16:10, 16 October 2006 (UTC)
thread_title: GA review

message: Heparin has the highest negative charge density of any known biological molecule. This helps it in its very strong electrostatic interaction with thrombin (in association with antithrombin). (Lehninger Principles of Biochemistry, 4th Ed.). Thought it would be worth mentioning in the article.TwoOars 01:01, 14 March 2007 (UTC)
thread_title:  Highest Negative Charge Density 

message: I'm confused about the latest edit. My references say heparin entered clinical trials in 1935, but the latest edit tell us that heparin preparations were toxic until 1937 when connaught started producing non-toxic heparin preparations. What was being used in the clincal trials in 1935 and 1936, toxic heparin !!! K.murphy 11:13, 27 March 2007 (UTC)
replies: text: I've changed the history to make it clear toxic heparin wasn't being used in clinical trials!! K.murphy 19:37, 21 May 2007 (UTC)
thread_title: Toxic heparin

message: And what about acid-based properties of heparin?  —Preceding unsigned comment added by 82.179.135.20 (talk) 06:34, 8 November 2007 (UTC)
replies: text: Like what? K.murphy 22:24, 12 November 2007 (UTC)
thread_title:  Acid-based properties 

message: Theres a section mentioning the uses of heparin in combating DVT and Pulmonary emboli, however it also says "but there is no evidence that they are effective at preventing death," but I have to ask, death from what?  It's an obsurdly vague cited statement that really only confirms that Heparin, like every other medication ever, doesn't make you immortal.170.173.0.16 (talk) 20:07, 27 February 2009 (UTC)
replies: text: I fixed this statement.  It cited an article which I read that compared LMWH to Heparin and found no difference in mortality.  It did NOT show no evidence of benefit from Heparin.  You would be hard pressed to find a recent study that compared Heparin to Placebo since such a study would be turned down by any ethics committee.  I also deleted some line about a Scottish recommendation for DVT prevention being aspirin.  There has been study in this area and aspirin is actually a poor choice for DVT prevention.Mrdeath5493 (talk) 07:05, 9 September 2009 (UTC)
thread_title: Medical uses

message: Just a quick note that the pKa of those sulfate groups is so low that they would never be protonated in water, as shown in the lewis structure on the main page.  Maybe in an organic solvent you could get them as drawn, but not in water.  I'd fix it, but my license for chemdraw just ran out.  —Preceding unsigned comment added by 128.104.119.87 (talk) 20:09, 30 March 2009 (UTC)
thread_title:  Unrealistic protonation state 

message: I work in the Pathology labs of the Midlands NHS and can safely say that all our Lithium Hep. tubes are bright orange, not green topped (those are citrate tubes). Seems a little silly to have a colour top in the article when all companys probably use different colours for their tubes.  —Preceding unsigned comment added by 146.227.1.14 (talk) 07:29, 18 January 2011 (UTC)
thread_title:  Green top tubes? 

message: There is no information regarding the use sodium heparin in topical cold sore medication (ex. lipactin). Gibby is gibby (talk) 16:42, 20 May 2011 (UTC)
thread_title: Use in cold sore medication

message: This edit added information saying excretion was done in urine. Perhaps so, after metabolism. I'm not up on pharmacology but this source says "Second, when used in clinical doses, UFH is not cleared by the kidneys..."  Biosthmors (talk) 17:24, 10 February 2012 (UTC)
thread_title:  Recent edit adding pharmacology information 

message: "Heparin is given parenterally because it is not absorbed from the gut, ..." Surely that should be, "Heparin is not given parenterally ...."  — Preceding unsigned comment added by Will Somers (talk • contribs) 14:14, 29 October 2014 (UTC)
thread_title:  Administration 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: doi:10.1111/jth.13555 JFW | T@lk 11:13, 28 December 2016 (UTC)
thread_title:  Historical review 

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thread_title:  External links modified 

message: Heparin more than anticoagulant doi:10.1111/bjh.14885 JFW | T@lk 12:30, 26 October 2017 (UTC)
thread_title:  Sepsis 

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thread_title:  External links modified 

message: The primary use of the term is for the medication. We have the article on Heparan sulfate. The less common meaning can be introduced latter in the lead. Doc James (talk · contribs · email) 03:02, 5 June 2019 (UTC)
thread_title: Primary use

message: 2016, only 66 pages doi:10.1124/pr.115.011247 JFW | T@lk 21:40, 26 October 2020 (UTC)
thread_title:  Pharmacology of heparin 

message: You can find a bit information with Google search 
enoxaparin OR heparin antiviral OR virus
But I don't know how promising is this for covid-19 and other viruses. 
--46.132.37.34 (talk) 23:19, 8 January 2021 (UTC)
thread_title:  Heparin is antiviral. covid-19 

message: "Since heparins depend on the activity of AT". In the beginning of the article. What is AT? It should be defined and linked. 81.185.172.172 (talk) 11:59, 22 November 2021 (UTC)
thread_title:  AT? 

message: I believe that the figure showing the General Structure of Heparin is erroneous. Namely, the leftmost saccharide (which I believe to be 2-O-sulfo-α-D-glucuronic acid) is not one of the possible saccharides mentioned later in the article (GlcA, IdoA(2S), GlcNAc, GlcNS, GlcNS(6S), or even the rare GlcNS(3S,6S)). The closest "valid" saccharide to the one shown in the figure would be IdoA(2S). The difference being that the COO- and OSO3- groups should be on the same side of the ring. I imagine the error stems from a desire to create a more readable structure, but as far as I can tell, is nonetheless invalid. G.Lazarski (talk) 04:06, 10 May 2023 (UTC)
thread_title:  Regarding the General Structure