Talk:Nabiximols

message: From the article: "Sativex Is basically a Liquid form of Marijuana with one exception, it cannot get you high"
Is this true? I would imagine that the only difference from marijuana is the delivery method, i.e., smoked vs. mucous membrane absorption/ingestion; if the THC and cannibidiol weren't affecting the central nervous system, how would they relieve pain?. Can anyone verify this? It seems a rather unsubstantiated and unscientific claim, but I'll leave it alone til some perspective is gained. — Preceding unsigned comment added by 67.10.68.139 (talk • contribs) 20:25, 29 September 2005 (UTC)
replies: text: I removed this unsupported assertion. If taken in sufficient amounts, Sativex will produce a high similar to smoking a spliff. JFW | T@lk 21:55, 29 September 2005 (UTC)
replies: text:  Not only that, but the instructions for the medication -specifically- state that 'intoxication' is a common side effect, especially when starting off. They also say that if intoxication occurs, one should taper back usage of the medication until it no longer is a problem. - Pacula 14:04, 10 May 2007 (UTC)
replies: text: I agree.  I actually have used this medicine and it can get you extremely high.  To get high from it, I've noticed that I had to do about three to four doses (sprays) at once, although I have taken as many as 10-15 sprays at once.  The effects, in my opinion, are slightly distinguishable from smoking cannabis though.  It's kind of like a cannabis-high with less of the feelings of mental euphoria but with more of the physical "body high" effects.  Keep in mind this is a cannabis high that comes through ingestion rather than smoking, so be prepared to be quite high for a long period of time, with the high "spiking" upwards during digestion.  I have been so stoned off Sativex at times, after dinner, I felt like I was losing my mind and could no longer comprehend or remember movies or television that I was watching.  Often I would simply lose conciousness when getting that high.  I would definately not recommend going out in public after doing more than two doses of this stuff.  Torkmann (talk) 05:28, 30 July 2009 (UTC)
thread_title:  Sativex 

message: "(Sativex will remain a Schedule 1 controlled drug in the UK)"
The UK doesn't use the Schedule system that America does. It uses a system of drug classes (Class A, B, C). Do they mean it's Class C (the same as cannabis atm) or what? Haddock420 01:43, 26 December 2005 (UTC)
replies: text: That came straight from the GW Pharmaceuticals press release dated 2005/11/15. Anarchist42 23:23, 26 December 2005 (UTC)
thread_title: Incorrect information

message: Lucky she didn't die. The Real Walrus 23:08, 1 June 2006 (UTC)
replies: text: From the Merck Index, 12th edition. 9349. The LD50 was measured in rats at 1270mg/kg (males) and 730mg/kg(females) given as an oral suspension in oil. It was 40mg/kg in male and female rats by IV.  The value for inhalation in rats (corrected for particulate losses etc) was 42mg/kg. The values are reported for the Δ9-THC isomer. Jeff Dahl 22:36, 3 September 2007 (UTC)
thread_title: A woman didnt suffered a fatality

message: This paragraph reads like an advertisement or promotional material from the company (bold text added to point out what I see as unencyclopedic, non-neutral text)
'"In February 2007, GW and Otsuka Pharmaceutical announced an exclusive agreement for Otsuka to develop and market Sativex in the United States. Otsuka is a major global pharmaceutical company, best known for its antipsychotic blockbuster medication, Abilify. Sativex has received permission from the US regulatory authority, the FDA, to enter directly into late stage Phase III trials in the US. The first large scale US trial in the US for cancer patients is expected to start in summer 2007.  The 300-patient, double-blind, randomized, placebo-controlled study will evaluate the effect of Sativex in relieving average daily pain, reducing the use of breakthrough opioid medications, improving the quality of sleep and relevant aspects of quality of life among other outcome measures."'
Particularly the last part: it seems predictive rather than narrative.  Also "expected to start in summer 2007" -- it is now 2008, so wherever this came from (no citation either) it needs to be updated.  I don't have the resources to correct this paragraph without damaging the good parts. User:Pedant (talk) 07:57, 5 January 2008 (UTC)
thread_title:  This  paragraph 

message: I'm a wiki newbie, and would like to rewrite to break out the position on availability by country. In particular the UK situation, where although the medicine is approved, the funding decisions of many health authorities make it impossible to actually obtain it. This is well attested in various news articles. I would submit that (UK wise) this is a very important fact, as the existence of SativeX has repeated been used in attempts to short circuit the wider issue of UK drug laws, and the medicinal values of cannabis.  — Preceding unsigned comment added by TheNoBrainer (talk • contribs) 18:10, 7 June 2011 (UTC)
thread_title: More details for availability

message: 'Schedules' in the UK are of the Misuse of Drugs Regulations 2001 (MDRs), and nabiximols may be schedule 1, which includes cannabis
I have yet to find any government statement, however, that nabiximols is cannabis for purposes of either the Misuse of Drugs Act 1971 (MDA), where cannabis is class B, or the MDRs, and government departments seem reluctant to respond to freedom of information requests on the issue
Generally, G W Pharma and the UK government are creating the impression that nabiximols is not cannabis, but for MDA and MDR purposes there seems to be nothing else it can be
See also Which ‘Controlled Drug’ is Sativex? at http://www.whatdotheyknow.com/request/which_controlled_drug_is_sativex, Is Sativex cannabis? at http://www.whatdotheyknow.com/request/is_sativex_cannabis and Sativex ingredients at http://www.whatdotheyknow.com/request/sativex_ingredients_2
Laurel Bush (talk) 10:57, 17 February 2012 (UTC)
thread_title: Nabiximols (Sativex): is it cannabis in UK law?

message: As the Dylan song, Union Sundown goes "I can see the day coming when even your home garden is gonna be against the law"  — Preceding unsigned comment added by 89.234.70.92 (talk) 19:55, 12 April 2012 (UTC)
replies: text: FYI, opium has been legal for decades, in the form of morphine ;-) --ἀνυπόδητος (talk) 20:47, 12 April 2012 (UTC)

text: So tired of stoner conspiracy theories. Plenty of people and groups make money off of tobacco, opium, etc. (all things you can grow on your damn own really easy, opium is like a weed.) Also, claiming a 1:1 THC/CBD combination product is medicinal cannabis is stretching the definition of cannabis. Considering that cannabis spp. has a much higher ratio of THC to CBD and other alkaloids, this isn't remotely like cannabis. Just like you wouldn't call cocaine a coca plant or morphine opium. C6541 (Talk ↔ Contribs) 19:44, 23 June 2013 (UTC)
thread_title:  I always said cannabis would be legalised when the drug companies( plus the medical profession ) could make money off it. Of course its still illegal to grow your own!  

message: The entire section is unbalanced, biased, it is written poorly and many of the claims are unsourced and do not have citations. Someone needs to sort it out or it should be deleted--Allthestrongbowintheworld (talk) 16:50, 18 February 2013 (UTC)
thread_title:  Controversy 

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thread_title:  External links modified (February 2018)