Talk:CYP3A4

message: Garlic should be added to the page due to its affect on CYP3A4 per http://copnt13.cop.ufl.edu/fdic5/narratives.php?cat=Garlic&usr=Professional as well as the mention in the paper and references http://www.scipharm.at/download.asp?id=652
Jerryfern (talk) 03:50, 20 July 2012 (UTC)
thread_title:  Garlic 

message: On the table where it list "Ligands, inducers, and inhibitors", St. John's Wort is listed under "inhibitors", while the St. John's Wort page lists it as an inducer.  The Irish Intinian (talk) 06:27, 27 October 2011 (UTC)
thread_title:  St. John's Wort 

message: The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
No links external or internal on this chunk of techno-speak!
And correct me if I am wrong but a protein that catalyze is usually called an enzyme?
Perhaps break it down:-
Start out simple
Proteins -> refer back to DNA
enzyme -> refer back to protiens 
call out technical terms such as metabolism/ize as digest/converts 
Then get technical
monooxygenases -> swaps electron-> puts a piss this out tag on it
The mouth chews
The guts mix it up
The liver sorts out the rubbish
The kidneys make piss; given red wine, fillet steak, semen  and diazepam...This is what happens
The anus should keep up with the mouth
Or else the semen will reduce
Left as it is this article only informs those who already know
80.7.74.46 (talk) 22:36, 3 May 2012 (UTC)
thread_title:  Do not copy and paste 

message: The source for milk thistle, "A Warning about Milk Thistle and Drug Interactions" on the website HVC Advocate (http://www.hcvadvocate.org/hepatitis/hepC/mthistle.html), references a twelve-year old in-vitro study(Venkataramanan R, Ramachandran V, Komoroski BJ, et al. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metabolism and Disposition 2000;28(11):1270-1273). In 2006, however, the paper "Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: Comparison of a milk thistle and black cohosh product to rifampin and clarithromycin" in the Journal of Clinical Pharmacology found that 300 mg, three times daily of a product standardized to contain 80% silymarin did not affect CYPA in vivo.
I do not know the latest findings, but the article is nevertheless outdated on this point.  — Preceding unsigned comment added by 67.169.12.236 (talk) 09:26, 8 November 2012 (UTC)
thread_title:  Milk Thistle 

message: This source
Bakalar, Nicholas. Experts Reveal the Secret Powers of Grapefruit Juice. New York Times. Published: March 21, 2006. Article
does not say grapefruit's interaction with the enzyme has caused several deaths. It says a couple of the drugs it interacts with can, if blood levels are too high (probably during a fairly long time) "lead to a serious and sometimes fatal muscle disorder called rhabdomyolysis." I put a dubious-label on the claim and removed the "source". Really I think the statement should be removed, it's a bold claim with nothing to back it up. --Stighammar (talk) 07:21, 3 April 2014 (UTC)
replies: text: Removed. Anastrophe (talk) 21:27, 24 February 2015 (UTC)
thread_title:  Grapefruit death 

message: Hello fellow Wikipedians,
I have just added archive links to  on CYP3A4. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive http://web.archive.org/web/20110721141830/http://www.aapsj.org/abstracts/AM_2009/AAPS2009-001235.PDF to http://www.aapsj.org/abstracts/AM_2009/AAPS2009-001235.PDF
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Cheers.—cyberbot IITalk to my owner:Online 20:14, 28 February 2016 (UTC)
thread_title:  External links modified 

message: This article has been stable for a while, but I made a few edits.  Still, the first sentence under "Mechanisms" needs some number-agreement work ("Cytochrome P450 enzymes perform ... utilizing its large active site and its ability to bind...")  "enzymes" and "its" don't match.  David10244 (talk) 15:55, 22 July 2023 (UTC)
thread_title:  Number agreement