Talk:Chitosan

message: Is it just me, or does the section cited by reference 17 reads like an advertisement? The only reference given is a whitepaper from the manufacturer's website. Removing it for now, until it can be rewritten with more encyclopedic language. --Revaaron (talk) 16:36, 3 July 2009 (UTC)
thread_title: Product Claims

message: Elicitation of Natural Defenses Response in Plants:
AgriHouse Inc (Denver, Colorado) has completed over 20 years of agricultural research on chitosan in conjunction with Dr. James Linden, Professor Emeritus, Departments of Chemical and Biological Engineering and of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado and Dr. Ken Knutson, Professor Emeritus, Plant Pathologist, Director Seed Potato Certification, Colorado State University, Fort Collins, Colorado. Richard Stoner, Founder and Pres., is a co-inventor, hold patents and pending patents on the defense elicitation of plants using chitin / chitosan.
DuPont-ConAgra Venture (DCV), Wilmington DE, was granted patents for spraying chitosan on the leaves of plants to elicit natural defense responses by the plants against pathogens and pesticides. AgriHouse has been assigned the DCV patents in 2009.
The EPA and USDA regulate the use of Chitosan on agricultural crops. Chitosan is known to elicit natural disease responses  and boost growth in plant and trees. see YouTube video 
In September of 2008 AgriHouse Inc was granted EPA registration (EPA reg. no. 83729-1) for YEA!® Yield Enhancing Agent, containing an active ingredient of 0.25% chitosan and 99.75%  inert materials.trytuiuiuiuiui
The following articles have been written by inventors:
Linden, J., Stoner, R., Knutson, K. Gardner-Hughes, C.  “Organic Disease Control Elicitors”.  Agro Food Industry Hi-Te (p12-15 Oct 2000)
Linden, J.C. and Stoner R.J.  2005.  Proprietary Elicitor Amends Potato Emergence and Yields.  Potato Grower.  April.  pp. 34-35.
Linden, J.C. and Stoner, R.J. 2005.  Proprietary Elicitor Affects Seed Germination and Delays Fruit Senescence. Journal of Food, Agriculture & Environment (in press).
Stoner, R., Progressive Plant Growing Has Business Blooming, Environmental and Agricultural Resources NASA Spinoff 2006, pp68-71.
Linden, J.C. and Stoner, R.J.  2007.  Pre-harvest application of proprietary elicitor delays fruit senescence.  A. Ramina et al. (eds.). Advances in Plant Ethylene Research: Proceedings of the 7th International Symposium on the Plant Hormone Ethylene. pp 301-302. Springer: Dordrecht, The Netherlands.
These articles and field trials with chitosan elicitors can found at http://www.yeacrops.com
--71.208.51.86 (talk) 18:27, 10 April 2009 (UTC)
thread_title: Agricultural Uses of Chitosan

message: Chitosan is often used in conjunction with Bentonite as a clarifying agent in wine making to remove unwanted cloudiness and hazes in the finished product. Kitsune818 13:44, 30 May 2006 (UTC)
thread_title: Clarifying agent

message: Chiosan will also increase the bioavailability of morphine.
Bioavailability of Morphine: Oral: ~30% Insufflated: 10-20%
Here's the VERY interesting part: Chitosan [a linear polysaccharide that helps absorb drugs better] has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%
Going from 20% TOPS, to over 60% for insufflation methods of ingestion.
here are the references (i wrote about in my diploma thesis):
Illum, L., P. Watts, et al. (2002). "Intranasal delivery of morphine." Journal of Pharmacology and Experimental Therapeutics 301(1): 391-400.
Pavis, H., A. Wilcock, et al. (2002). "Pilot study of nasal morphine-chitosan for the relief of breakthrough pain in patients with cancer." Journal of Pain and Symptom Management 24(6): 598-602.
best regards 130.208.188.119 01:16, 4 June 2007 (UTC)
thread_title: Unreferenced claim

message: If you can, please clarify whether chitosan is ever found in nature, or if ALL chitosan is derived from chitin. ike9898 (talk) 15:15, 25 August 2010 (UTC)
thread_title:  Clarify 

message: Maybe it can be claimed that chitosan doesn't bien important minerales, but it can't be claimed that  "there is no proof of any adverse events, in particular regarding nutrient absorption, in humans" as long as it binds fat, and there are vitamins that ARE fat like vitamin E or vitamin D  — Preceding unsigned comment added by 193.144.79.183 (talk) 13:49, 24 January 2012 (UTC)
thread_title:  SAFETY 

message: As a biologist who's looking for factual information about chitosan, this article reads in a very unbalanced way. In fact, it reads almost like an advertisement for a product from two people whose patent applications are cited repeatedly in this article. It would be a very good idea for a biologist or biochemist with specialist knowledge of this area to edit the page thoroughly and for claims of biological and agricultural activity to be presented in a more balanced manner. OldSpot61 (talk) 10:18, 5 December 2012 (UTC)
replies: text: Perhaps apply at the Task Force for someone like that to take a look? Guess you mean Linden/Stoner; have merged 2 refs (2007). To be fair, there are over 40 refs to other people's papers; perhaps L&S are just good active researchers in this field. Does need an expert to assess. Chiswick Chap (talk) 10:47, 5 December 2012 (UTC)
thread_title:  Infomercial? 

message: I am having an edit war with an unregistered user who has adopted a Harvard myopic that all credit for "bioinspired" industrial uses of chitosan is awarded to a Harvard lab. The editor uses only Harvard references while there is abundant precedence in the literature for prior art, publications or applications. The section below has been reverted twice, so consider further reversals of what I intended to be a WP:NPOV version with references of varied origin as edit warring,WP:3RR. A fair-minded view, which I have invited to be discussed on this Talk page, would be for the Harvard editor to explain reasons why that bias is valid. --Zefr (talk) 00:57, 26 May 2014 (UTC)
replies: text: Please register or identify your affiliation so we are assured your edits are WP:NPOV and not WP:COI. Also please sign with your signature and timestamp. I suspect you are the author himself or someone in the same lab group, giving a strong bias toward the Harvard lab as having solely established this concept despite evidence in the literature that these concepts have been building toward chitosan consumable products for many years based on the work of others. Citing that literature evidence is part of the purpose for the Article; see WP:CON. --Zefr (talk) 17:12, 26 May 2014 (UTC)

text: It seems unrealistic to assign all responsibility for development of chitosan consumables and even to Shrilk as only a Harvard discovery, given the work of the Houston group. --Zefr (talk) 17:12, 26 May 2014 (UTC)

text: Fair enough, but as a courtesy to my or any editor's work to edit the text and find supportive references possibly helpful to others, it's beneficial to edit the revision rather than reverting it wholescale. --Zefr (talk) 17:12, 26 May 2014 (UTC)

text: There seems abundant evidence that chitosan is biodegradable, non-toxic and safe, indicating my statement was general and reasonable. --Zefr (talk) 17:12, 26 May 2014 (UTC)

text: Please register and sign your comments. This statement is easily edited rather than being wholesale reverted. I will be editing this section again. --Zefr (talk) 17:12, 26 May 2014 (UTC)
thread_title: Harvard myopic? --> Manufacture with chitosan by Zefr: Erroneous explanation of the technology and blatantly false claims. 4 times reverted corrections

message: Your comments above reveal you are too close to the Harvard work to provide Wikipedia with WP:NPOV, establishing you as WP:COI. I suggest you read WP:NOTJOURNAL, WP:! and WP:SOAP. Your edits deriving from conflict of interest deflect from balanced content as intended by Wikipedia, WP:BALANCE. 
--
I don't think this discussion should be here Zerf, since it doesn't have anything to do with actual information about chitosan. I am from the same institution of the people manufacturing the chitosan objects, a fact I have never tried to hide. I don't think I fit in the definition of COI since I don't have any interest on this information and I don't have a personal relation with the authors (and I am not writing about them or our common institution)WP:GF. Be part of the same research institution is as good reason as, for example, be from the same country. Sure Wikipedia could be used to promote points of view and interests from a university or country, but I don’t understand why you assume a biased opinion if there is no personal interest involved.
I believe I did a good and neutral review of a topic I know, and I can't see how I personally can benefit from the text I wrote. Actually I deliberately avoided the inclusion of patents (which are very detailed about the process). I sincerely believe your claim of WP:COI lacks of any solid argument. Also I don't understand what kind of WP:BALANCE provided your edition if you didn't make available any reputable source to support the claims you introduced.
--24.218.80.193 (talk) 00:08, 29 May 2014 (UTC)
thread_title: User 24.218.80.193 and COI

message: The structure shows a fully-deacetylated molecule. If my understanding of chitosan is correct, then this is somewhat misleading, as chitosan is supposed to have both deacetylated and acetylated residues.  — Preceding unsigned comment added by 173.161.140.105 (talk) 17:54, 24 August 2015 (UTC)
thread_title:  Structure 

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thread_title:  External links modified 

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thread_title:  External links modified 

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replies: text: Ok. --Zefr (talk) 14:29, 5 August 2017 (UTC)
thread_title:  External links modified 

message: About the content below
;Potential industrial uses
Scientists have developed a polyurethane coating that heals its own scratches when exposed to sunlight. The self-healing coating uses chitosan incorporated into traditional polymer materials, such as those used in coatings on cars to protect paint. When a scratch damages the chemical structure, the chitosan responds to sunshine by forming chemical chains that bond with other materials in the substance, eventually smoothing the scratch. The process can take less than an hour.
The polymer can only repair itself in the same spot once, and would not work after repeated scratches. Whether this technology can be applied to industrial materials, however, depends on a number of factors, such as long-term persistence of the repair, stiffness and heat resistance of the coating.
So scientists from University of Southern Mississippi did some work on incorporating chitosan into paint coatings in a way that "self-healed" when exposed to sunlight.  They got this published in Science in 2009 and it got a lot of hoopla (even the NYT mentioned it).  A lot of "could be" usefuls... and also a lot of "we are not sure how wide the scratch can be" and "we are not sure if it works more than once" and other questions.  
Here we are eight years later; I just looked and there is no evidence this is actually used in products.  I went to the website of the USM technology transfer office (here) and they have an excel document you can download that lists their "technologies available for licensing" and the first entry is this invention  - entry from the excel table is copied here:
:USM Tech ID: 2013.0159	
:Title: Self-repairing cyclic oxide-substituted chitosan polyurethane networks	
:Description: Thermosetting polymeric compositions, such as polyurethane compositions, and related methods are provided. The invention relates to coating and polymer compositions and related methods derived from a biodegradable natural polysaccharide compound such as chitosan, pectin, heparin, and combinations thereof reacted to a cyclic oxide compound, such as an oxetane, oxolane or oxepane compound. The compositions and methods of the present invention exhibit self-repairing properties upon exposure to ultraviolet (UV) light. The compositions and methods of the present invention can be used in many coating applications, such as the transportation, packaging, fashion, and biomedical industries.	
:Patent: 8,658,786
There are zillions of papers out there where academics did something neat that may or may not ever become actual uses.  I doesn't make sense to me to keep this kind of thing around, especially under a label of "Potential industrial uses" Jytdog (talk) 18:00, 9 October 2017 (UTC)
thread_title:  self-healing coatings 

message: The cited study is a 2008 Cochrane review. This was a good meta-analysis, but is now a decade old. There has not been comparably good meta-analyses since, but there have been studies, which tend to show Chitosan being effective for weight loss (such as https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0122-8 ). At what point do more recent studies get included in the article?Wikiditm (talk) 08:08, 6 November 2018 (UTC)
replies: text: We don't edit based on primary sources, but rather reviews.... I just checked pubmed and there is a review from 2016 (PMID 27053066) that has the same conclusion. It cites the cochrane review and an earlier Ernst review, then says  "Given the fact that chitosan is supposed to increase fecal fat excretion, clinical trials have evaluated this effect but have found only a non-significant difference in fecal fat excretion after chitosan administration [81, 82]. Finally, one clinical trial compared the effects of orlistat (a pancreatic lipase inhibitor) vs chitosan on fecal fat excretion, finding that the latter did not inhibit dietary fat absorption [83]. Given the aforementioned results, it may be observed that although chitosan might have an effect on weight loss, that loss is not clinically significant and therefore should be interpreted cautiously."  Will add it. Jytdog (talk) 15:13, 6 November 2018 (UTC)
thread_title:  Weight Loss Studies 

message: This revert was necessary because most of the sources are from lab research too preliminary to use in the encyclopedia. Sources needed are reviews as described in MEDRS. Zefr (talk) 19:40, 8 December 2022 (UTC)
replies: text: These sources are lab research and do not meet MEDRS. Zefr (talk) 19:46, 8 December 2022 (UTC)
thread_title:  Primary research does not meet [[WP:MEDRS]]