Talk:Sulfasalazine

message: The mode of action of sulfasalazine is through release of a metabolite, 5-amminosalicylic acid (5-ASA), which is an NSAID.
Aspirin (commonly abbreviated as "ASA") is acetylsalicylic acid, whereas 5-ASA is aminosalicylic acid.  This may be your point of confusion.--69.180.214.43 18:57, 21 June 2007 (UTC)
thread_title: NSAID?

message: Just some general mechanism/proposed mechanism info. Sulfasalazine, as discussed, has no inherent anti-inflammatory properties, but its metabolite, 5-ASA, does. Salicylates and other NSAIDS act via prostaglandin synthesis blockage, but aminosalicylates like 5-ASA vary in their inhibition of PG, so this isn't a complete explanation. A widely accepted theory is that 5-ASA attenuates the inflammatory products of the cyclooxygenase and lipoxygenase pathways. Another prominent theory is that 5-ASA appears to inhibit leukotriene and other inflammatory cytokine production, and has been proven to inhibit nuclear fcator kappa B, a primary transcription factor for inflammatory cytokines. Finally, 5-ASA may inibit functions of natural killer cells, mucosal lymphocytes, and macrophages (which release large quantities of inflammatory cytokines), and may scavenge oxygen radicals. These theories make sense in that ulcerative colitis and Crohn's disease are inflammatory diseases, and inflammation is caused by a response by the immune system. That is not to say that these diseases are autoimmune in nature; it's very possible that the disease are caused by an abnormally high production of proinflammatory cells, or that those cells produce abnormally large amounts of cytokines (I'm not putting that in the article because that's my own proposition based on my own research). This would also explain why patients presenting with ulcerative colitis can also have arthritic symptoms (arthritis is an inflammatory joint disorder). It is important to note that sulfasalazine, being a "prodrug" is not an analgesic, as M Dorothy stated, but 5-ASA can exhibit indirect analgesic properties (meaning it does not directly stop pain signals or reduce pain perception, but can decrease inflammation that is causing pain). There's a difference between the two. I hope this information is useful. It was taken primarily (not verbatim) from Basic and Clinical Pharmacology, 10th edition by Bertram G. Katzung, MD, PhD, with the particular chapter written by Kenneth R. McQuaid, MD. Just giving credit where it's due! I'm gonna bust out some randomized trials and then I'll make some edits. If anyone has any good trial info to contribute, that'd be helpful. Thanks! Ohnoitsthefuzz 05:32, 2 October 2007 (UTC)
thread_title:  Mechanism of action 

message: 1. the indication section should be brief and not contain complex trial data. The trial data should be referenced
2. sulfasalazine is considered first line treatment for rheumatoid arthritis. "it is also effective" is a bit weak considering the importance of this drug to rheumatologists.
3. "it is surprising" - surprising is a personal adjective
4. "Most often we find " - who is WE? Articles should be written in third person
5. "Sulfasalazine in rare cases can cause severe depression in young males." - interesting to put this in considering how far down the list this particular side effect is. I do believe even something as random as ataxia is a more common side effect.
6. "but should you wish to become pregnant, you should discuss this with your rheumatologist." and "If however you develop a sore mouth, mouth ulcers, easy bruising, nosebleeds or bleeding gums, your doctor should be notified immediately." and others like these - wikipedia articles are ideally objective, peer reviewed, cited, balanced and third party. They are NOT patient leaflets or advice centres.
Hope these ideas help. PhatRita (talk) 23:24, 24 November 2008 (UTC)
thread_title:  whole thing needs work 

message: As it's an azo compound, 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid, there should be a double bond between the salicylic acid nitrogen and the sulfa moeity. Also, the salicylic acid moeity should have a hydroxy group (not a keto) at carbon 2...
Mike Zinkievich (talk) 20:27, 20 April 2009 (UTC)
replies: text: Changed the name to diazenyl or azo as well. --kupirijo (talk) 10:16, 14 January 2011 (UTC)
thread_title:  Structure 

message: Does that section really need so much information on a possible toxicity?  It looks a bit odd as it is...ChillyMD (talk) 22:50, 3 May 2009 (UTC)
thread_title:  Indications

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thread_title:  Copyright problem removed 

message: My doctors prescribed sulfasalazine when Jacobus Pharmaceutical stopped making sulfapyridine available around January 2011. The doctors prescribed supfasalazine to treat (the symptoms of) dermatitis herpetiformis (DH - an allergy to gluten which causes skin rashes). Doctor reference: Dr. Andrew Scheman, Dr. Todd Johnson (dermatologists) of Northbrook & Chicago IL. (Another drug prescribed for DH was dapsone (used to treat leprosy).) Please incorporate what you want from my input. I'm not a doctor. PReinie (talk) 15:42, 25 January 2011 (UTC)
thread_title:  Also used to treat 

message: The article contradicts itself saying sulfasalazine has no immunosuppressive effect but it can cause agranulocytosis, which seems to be major suppression of the immune system. Which is it?  — Preceding unsigned comment added by 72.24.31.36 (talk) 12:33, 25 December 2011 (UTC)
thread_title:  Immunosuppression or no? 

message: Not mentioned in article. 86.159.197.174 (talk) 19:31, 25 August 2014 (UTC)
thread_title:  Why does "salicylazosulfapyridine" redirect here?