Talk:Sjögren syndrome

message: This last story about Omega EFA with Vitamin E is complete BSJfmarchini 02:39, 10 November 2006 (UTC)
thread_title:  Omega EFA with Vitamin E 

message: The sentence " HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients" doesn't make any sense. Greek and Israelis are Caucasian.  — Preceding unsigned comment added by 61.223.2.83 (talk) 13:20, 29 November 2013 (UTC)
thread_title:  research 

message: i think you can get sjogren's symptoms with scleroderma.  we probably should add that somewhere. 207.151.234.103 (talk) 23:28, 7 April 2008 (UTC)
thread_title:  scleroderma 

message: According to http://www.lupusnsw.org.au/sjogrens.html there is often a connection with Lupus... This should be mentioned Vk2tds (talk) 09:50, 23 October 2008 (UTC)
replies: text: what you both fail to realize is that this is a wikipedia talk page. it is for discussion of the article, not discussion of the article's topic.there are,i'm sure, numerous discussion sites for both sjogren's and lupus, and all related issues. this is not the place.Toyokuni3 (talk) 18:41, 24 July 2011 (UTC)
thread_title:  Lupus 

message: Mikulicz disease(MD) should not link to the Sjogren page.  MD is a constellation of clinical findings (bilateral painless swelling of lacrimal, submandibular, parotid glands for greater than 3 months), thought to be a consequence of IgG4-related sclerosing disease.  Sjogren's may occasionally result in something like MD but the terms are not synonymous.
Pwawryko (talk) 15:56, 15 September 2010 (UTC)
thread_title:  Mikulicz disease 

message: An edit earlier today added Venus Williams to the see also section, noting that she has recently been diagnosed with the syndrome. I removed this link as it appears trivial and out of place. I doubt it is common policy to reference celebrities with diagnosed conditions outside their own article. I just wanted to have a record of why I made this edit. IrishStephen (talk) 01:27, 1 September 2011 (UTC)
replies: text: I'm not a *strong* proponent of having it in the article, but it is notable, and it would give a good "visual aid" or real-life example of the condition that people may be familiar with, which could be a good thing. I guess my vote would be in favor of mentioning it, not that we are voting... but only if it can be done in a way that is not awkward and doesn't decrease the readbility of the article. Dr.queso (talk) 22:08, 30 May 2012 (UTC)
thread_title:  Venus Williams 

message: I have both and I have looked online and seen other people with both. I don't believe this statement is true.  — Preceding unsigned comment added by 50.47.115.59 (talk) 00:22, 29 April 2012 (UTC)
thread_title:  SS excluded from people with sarcoidsis? 

message: The current text reads:  "Typical Sjögren's syndrome ANA patterns are SSA/Ro and SSB/La, of which SSB/La is far more specific; SSA/Ro is associated with numerous other autoimmune conditions, but are often present in Sjögren's. However, SSA and SSB tests are frequently not positive in Sjogren's syndrome."
While factually true, the last line is grossly misleading. The informational content of the last sentence can be substantially improved to be genuinely useful and correct for readers, as follows.
Patients who are seronegative for SSA and SSB antibodies require a mandatory positive lip biopsy result to receive a diagnosis of Sjogren's.  One definitive reference for the this comes from Dr. Alan N. Bauer, (2012, The Sjogren's Book, Sjogren's Syndrome Foundation,  Wallace, Daniel J. editor;  Table 18-1 Diagnostic Testing in Sjogren's, pg. 174.  This Sjogren's Foundation-published reference is definitive enough, however, numerous additionally valid and equally specific references are readily available for this common diagnostic, non research, criteria for the routine diagnosis of Sjogren's and are easily found.  
The last line of the cited text (above) is grossly misleading, indicating simply that patients frequently test negative for SSA and SSB antibodies and are still diagnosed with Sjogren's.  
One (obvious) problem is this:  without a positive SSA test, or a positive SSB, or else a positive lip biopsy, then patients simply have nonspecific symptoms of dry eye and/or dry mouth, and/or other nonspecific symptoms.  There has to be some specific diagnostic indicator for Sjogren's: if nonspecific symptoms are the sole diagnositc criteria, then there are no criteria for diagnosis of Sjogren's, anyone who claims to have nonspecific symptoms or "seronegativity" can then have it, and the diagnosis then means nothing.  As the text is currently written, many people who are seronegative for SSA and SSB antibodies have no guidance in what commonly constitutes a valid diagnosis of "serognegative" Sjogren's, and may therefore spend additional years lost in the despair of remaining undiagnosed before discovering that they need for the lip biopsy to establish a seronegative diagnosis.
As is stated in the mandatory criteria for diagnosis of Sjogren's Syndrome by Dr. Baer, a patient must have either positive SSA antibodies, positive SSB antibodies, or in the absence of these, a positive lip biopsy to receive a valid diagnosis of Sjogren's Syndrome.  The last line of the cited text needs to be revised to provide this important and relevant fact.— Preceding unsigned comment added by 208.123.190.37 (talk) 05:16, 4 December 2014 (UTC)
thread_title:  Diagnosis 

message: doi:10.1111/bjh.13192 - BJH review JFW | T@lk 09:21, 22 January 2015 (UTC)
thread_title:  Lymphomas in people with Sjögren's 

message: I think there's an error in the Epidemiology section of the page. The wikipedia page says that Sjogren's is the third most common autoimmune disease, with SLE being more common than Sjogren's. However, the citation linked to that statement actually specifies Sjogren's as being the second most common autoimmune disease. The SLE page on Wikipedia lists the global prevalence of SLE at approximately 20-70/100,000 people (0.02-0.07%). The Sjogren's page estimates the prevalence of Sjogren's at up to 3% of the population, which makes it several orders of magnitude more common than SLE if the SLE prevalence information is correct. I think the start of this section should say (based on the references given and the prevalence information given) that "Sjogren’s syndrome is the second most common rheumatic autoimmune disorder, behind only rheumatoid arthritis (RA)." i.e. Without the reference to SLE as well. However being a medical page, I didn't want to make the edit without someone more knowledgeable in the field reviewing the changes first. 58.96.87.33 (talk) 13:48, 3 March 2015 (UTC)
replies: text: @58.96.87.33 Should the statement just be deleted? The full statement as it currently exists is inconsistent ("Sjögren's syndrome (SS) is the second-most common rheumatic autoimmune disorder, behind rheumatoid arthritis and systemic lupus erythematosus"), the freely accessible portion of the citation doesn't clarify (it says SS is second, but not what's first), and I'm unable to find such a ranking or comparison elsewhere (some time in particular spent digging through free articles on PubMed). The cited article is also from 2000—not very current. Half-delighted (talk) 05:27, 18 September 2023 (UTC)
thread_title:  Epidemiology 

message: >Though the cause of Sjögren’s syndrome is unknown, it is believed to be under the influence of a combination of genetic, environmental, and several other factors,
Is there a better phrase for "...believed to be under the influence of...."?  "It is controlled by a combination of genetic etc"?  "Influenced by a combination of genetic etc"?  Thank you. Rissa, Guild of Copy Editors  (talk) 03:39, 1 April 2015 (UTC)
thread_title:  Under the influence 

message: Why should the gum for mouth dryness be "preferably sugar free"?--Richardson mcphillips (talk) 20:46, 10 November 2017 (UTC)
replies: text: Sugar free gum is to lessen the possibility of tooth decay, since Sjogren's patients often have dental decay issues due to reduced saliva flow. Also, since Sjogren's patients often have gastrointestinal disturbance issues, especially achlorhydria, sugar free gum will be less likely to upset the stomach. JGKlein 21:39, 10 November 2017 (UTC)

text: The only answer that is relevant here, is "because that is what the source says". This is not the reference desk. Jytdog (talk) 16:35, 11 November 2017 (UTC)
thread_title:  gum (preferably sugar free) 

message: why don't we use estrogen with females?
Higher incidence in females seems to be due to the frequent loss of estrogen.
This is the section where the author mentioned androgen treatment suggestion:
"It has been hypothesized that androgen administration to the ocular surface may serve as an effective therapy for dry eyes."  — Preceding unsigned comment added by Yasir muhammed ali (talk • contribs) 10:10, 27 July 2018 (UTC)
thread_title:  Topical ocular androgen  

message: e.g. https://www.smartpatients.com/conversations/fatigue-surprisingly-little#top  — Preceding unsigned comment added by 5.66.63.86 (talk) 02:52, 1 May 2023 (UTC)
replies: text: This is not WP:MEDRS quality, it's not an WP:RS by any means. — Shibbolethink (♔ ♕) 16:42, 6 May 2023 (UTC)
thread_title: article should refer to fatigue

message: Greetings,
My Nurse Practioner thinks that I may have Sjögren's Syndrome as I seem to have some symptoms. But after reading about the condition on the 'net, it can be horrifying. I am certainly not sick like the descriptions suggest; I do not feel sick at all. 
So, is there a range of severity for this condition - from mild to very severe? The NP gave me an appointment for a rheumatologist, but I hate to waste everyone's time if the condition always manifests as severe and I am sans-SS. 
I am NOT asking for medical advice or a diagnosis, only if there is variation in the level of severity. Thank you for your time, Wordreader (talk) 18:56, 14 November 2023 (UTC)
replies: text: Make that "if there is significant variation in the level of severity". Thanks again, Wordreader (talk) 20:15, 14 November 2023 (UTC)
replies: text: @Wordreader, I believe that, at least in the earlier years, the symptoms are often so mild that the diagnosis is missed entirely.  I don't know if it always becomes severe (I doubt it; variability is typical of autoimmune diseases), but I can tell you that the people who hang out on medical internet forums aren't representative.  It's a bit like everyone else at the gym looking better than you – not because you're worse than average, but because the people you see the most of are the ones who spend all day, every day working out, and the ones you see the least of are the ones who zipped in, did the minimum, and rushed back out. WhatamIdoing (talk) 21:10, 14 November 2023 (UTC)
replies: text: @WhatamIdoing - Thank you so much for your reply. I guess I better keep the rheumatology appointment, then. Bleeech! >_< Wordreader (talk) 21:23, 14 November 2023 (UTC)
thread_title:  Variation in severity? 

message: I believe the experts have changed Sjogrens from a syndrome to a disease. 73.44.92.20 (talk) 12:34, 1 May 2024 (UTC)
thread_title:  Sjogrens