Talk:Fibrodysplasia ossificans progressiva

message: Suggested template for Orthopaedic Conditions (see Talk:Orthopedic surgery) is 
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Pathology
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Natural History/Untreated Prognosis
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Investigation
Non-Operative Treatment
Risks of Non-Operative Treatment
Prognosis following Non-Operative Treatment
Operative Treatment (Note that each operations should have its own wiki entry)
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--Mylesclough 05:38, 8 October 2005 (UTC)
thread_title: template for Orthopaedic Conditions

message: This site says 2,500 have been reported (1 in 2,000,000) to date.  The most recent date is April 23, 2006.
http://www.usbjd.org/projects/project_op.cfm?dirID=142
Stovetopcookies 08:35, 16 May 2006 (UTC)
thread_title:  Statistics 

message: This disease was features in today's Qwantz would it be appropriate to create a Popular Culture section and mention it?
No.  I came here because of the mention in Qwantz as well, but I don't think that nearly relevantNjerseyguy 20:20, 14 January 2007 (UTC)
thread_title:  Qwantz 

message: Note that the info from Discovery disagrees with the 'Statistics' above. Until someone finds a published source, please stop reverting unconfirmable information you saw on cable. Cable show are not good sources for an encyclopedia. —The preceding unsigned comment was added by Lord Kelvin (talk • contribs) 01:17, 22 June 2006  (UTC)
In the study by Gannon (entitled "Mast Cell involvment in fibrodysplasia ossificans progressiva") formation of lesions in this disease are linked to activation of inflammitory mast cells. This means any injury resulting in inflammation and therefore activation of mast cells can trigger the formation of bone. This disease is not however caused by injury and has usually been found to follow a classical endochondral ossification pathway found in developing embryo. For more info read the article "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva-Like Phenotype" by Lixin Kan.  —Preceding unsigned comment added by 134.50.25.59 (talk) 23:46, 26 September 2007 (UTC)
thread_title: Contradictory info from Discovery Health

message: i have seen this spelled fibrodysplasia ossificans progessiva, 
progessiva instead of progressiva. can anyone verify this?
Jbpanther20 00:00, 29 August 2006 (UTC)
thread_title:  misspelling of title 

message: A haunting picture of Harry Eastwick appears side by side with his skeleton (post mortem) is available here (google image frame. The original page is here.  Anyone with some time might want to add the photo or at least link to it. Njerseyguy
On a side note, I can't spell worth a damn Njerseyguy 20:27, 14 January 2007 (UTC)
thread_title:  Excellent picture. 

message: The "cases" section of this article starts talking about someone named "Mr. Eastlack." The second paragraph starts referring to someone who can only move their lips, but never says their name. The third paragraph mentions a "Mr. Eastlack." Is Mr. Eastlack the person from the second paragraph? Does Mr. Eastlack have a full name? Is he worth mentioning? Please, REWRITE THIS SECTION.
(No, I'm not a real doctor)
Dr. Mordecai 01:48, 23 March 2007 (UTC)
thread_title:  Mr. Eastlack's Case 

message: The entire "Cases" section doesn't have any referrences. I would suggest citing the Mutter museum website, which has a brief description of the specimen and an image, but as I am inexperienced in Wiki formatting I'll leave that to someone else. The part about accounts in the 1800s might need to be removed--there's accounts of human petrification in the Bible, for one thing, and for another without any sources at all this seems irrelevant.  —Preceding unsigned comment added by 66.245.93.148 (talk) 22:02, 29 January 2008 (UTC)
thread_title:  Referrences 

message: "Injuries from falling can provoke the bone growth and should be avoided." Is this really necessary? I think 10 out of 10 doctors recommend not falling, even for those not affected by FOP. -- MacAddct  1984 (talk •  contribs) 15:15, 5 May 2008 (UTC)
replies: text: The important part of the sentence is "Injuries from falling can provoke bone growth".  This is an important statement since the disease affects children in an age range where falls and horseplay is quite common and considered normal behavior.  Children with FOP can not be allowed to 'play' like this as it increases the chance of injuries, which leads to bone growth.   -- ShinmaWa(talk) 14:48, 27 June 2008 (UTC)
thread_title:  Injuries from falling... 

message: I don't understand why doctors can't just take some recombinant rat BMP4, mix it up in an adjuvant, and inject it into these people until they develop an autoimmune response.  Is anyone working on this? Wnt (talk) 01:36, 7 May 2009 (UTC)
thread_title:  Why can't they destroy the BMP? 

message: Please change the following sentence in the "Symptoms" paragraph: "The gene that causes ossification is normally deactivated after a fetus' bones are formed in the nutsack, but in patients with FOP, the gene keeps working." The word "nutsack" should be changed to "uterus."
Cchen91765 (talk) 16:01, 28 March 2010 (UTC)
thread_title:  Edit request 

message: In the "Skeleton Key" documentary it was stated that the white blood cells deposit BMP4 into sites of injury, which promotes conversion of tissue to bone. Seems to me the obvious treatment is to "nuke and pave" by destroying the source of the malfunctioning lymphocytes and replacing it, same as is done for other disorders caused by bad bone marrow. As has been done with leukemia, a method of sorting and culturing marrow cells without the defect would allow an autograft and no need for anti rejection drugs. Once the progression is stopped it woul be possible to do surgery to remove the bone growths. 174.145.244.98 (talk) 11:54, 4 March 2012 (UTC)
thread_title:  Would a bone marrow transplant work? 

message: This article has severe sourcing issues. News articles etc are not suitable. All medical content on wikipedia should be sourced per WP:MEDRS. I will tag the sources that need to go for now. Lesion (talk) 10:58, 26 August 2013 (UTC)
thread_title:  [[WP:MEDRS]] 

message: The IFOPA website has a problem, and I have removed all links to it from Wikipedia until the issue is resolved. See Wikipedia talk:WikiProject Spam/2013 Archive Jan 1#International Fibrodysplasia Ossificans Progressiva Association for details. --Guy Macon (talk) 08:14, 8 November 2015 (UTC)
thread_title:  Do not link to ifopa.org 

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