Talk:Equine exertional rhabdomyolysis

message: This is brand new, 2007 Morris Animal Foundation research and needs to be added into the article in a way that is not a copyio:
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Hereditary Disorders 
"Mapping the Recurrent Exertional Rhabdomyolysis Gene in Thoroughbred Horses" 
University of Minnesota, James R. Mickelson, PhD 
Completed: October 2007 
Description: 
A recurrent form of the heritable muscle disorder, tying-up is common in thoroughbred horses. Also called recurrent exertional rhabdomyolysis  (RER), this condition causes painful cramping and muscle damage that occurs after mild to moderate exercise. Although related muscle disorders exist in other species, RER in thoroughbreds appears to be a novel genetic defect. The investigators in this study seek to locate the chromosomal position of the RER gene. Identifying a DNA marker closely associated with the RER gene would allow them to identify the precise genetic alteration that causes tying-up, predict which horses are susceptible and develop specific therapies and treatments for horses affected by this disorder. 
Results: 
Researchers determined that susceptibility to RER is highly heritable in thoroughbred horses and is likely a novel muscle disease that affects the regulation of muscle contraction. Although the specific RER gene and the mutation that causes that disease have not yet been identified, when its location is found, it will allow for a more accurate diagnosis of RER susceptibility. Through this study, researchers learned a great deal about how to design and implement genetic mapping studies in horses, and this knowledge has allowed them to take the leadership role in Morris Animal Foundation's Equine Consortium for Genetic Research. They feel RER will be one of the first diseases mapped using the SNP chip technology that is being developed through the consortium. 
Source:  http://www.thehorse.com/ViewArticle.aspx?ID=10990
------------------------  —Preceding unsigned comment added by 161.7.2.160 (talk) 20:32, 18 December 2007 (UTC)
thread_title: Untitled

message: This article is outdated in the belief that there is one common rhabdomyolysis. Here's an excerpt from the Merck veterinary manual (fetched on April 5, 2008):
"Although exertional rhabdomyolysis was previously considered a single disease described as azoturia, tying-up, or cording up, it is now known to comprise several different myopathies, which, despite similarities in clinical presentation, differ significantly in etiopathology."
http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/91006.htm
This new information about the different categories of rhabdomyolysis needs to be added to this article and the title of the article changed to exhibit this change in the latest knowledge about exertional myopathies in horses.
:Go for it, and please add that source as a footnote.  We would sure appreciate an update! (Lots of us are aware of several articles that are outdated, but no time to fix...)   Montanabw(talk) 03:38, 6 April 2008 (UTC)
thread_title:  Equine Exertional Rhabdomyolysis is not just one disease 

message: Useful material to redo this article.  It needs it.  Montanabw(talk) 21:16, 23 March 2013 (UTC)
thread_title:  More new sources 

message: The part of the article containing information on anaerobic and aerobic metabolism is rudimentary at best and inaccurate at worst.  I did correct that lactate is a fuel ONLY aerobically.  All should be rewritten with CITED information.
Not all horses are male, so I converted all he/him references to it.  As this is marginally/arguably accurate only for geldings, it is still incorrect, but American English seems to use it when gender is unknown, as is the case here.  If only stallions are affected, which I doubt, then I stand corrected.  2603:8080:B203:79BD:4417:4A4D:6D36:A919 (talk) 21:34, 20 August 2021 (UTC)
thread_title:  Biochemistry and gender 

message: This article was lacking proper citation and needed more sources added as well. Research was done and the following sources have been added to this article.
Biles, Amanda L (2015). Horse Health: Tying-Up and Azoturia, a Metabolic Disorder: Typing-Up and Azoturia are Equine Exertional Rhabdomyolysis, the most common muscle problem in horses. Equestrian's Academy: Equestrian's Academy.
"Nutrition Info: Nonstructural Carbohydrates". Integrity Horse Feed. Retrieved 2021-11-11.
"StackPath". www.gardeningknowhow.com. Retrieved 2021-11-18.
"Azoturia | Equimed - Horse Health Matters". EquiMed. Retrieved 2021-11-19.
"Horse Healthcare Information Sheets". Scarsdale Vets. Retrieved 2021-11-20.
"Exertional Myopathies in Horses - Musculoskeletal System". Merck Veterinary Manual. Retrieved 2021-11-20.
The information in this article also was only identifying one type of Equine exertional rhabdomyolysis (ER), and was not identified, additional information based on types has been added to the article in all sections to identify both Sporadic and Chronic differentiations for equine ER.
Due to the original source not being accessible it was removed and all information was resourced from the other sources listed above.
As a note the first source is a source that does need to be purchased to read and view. It is available on Amazon.
--Phantom's Apprentice (talk) 03:22, 20 November 2021 (UTC)
thread_title:  Adding to Equine exertional rhabdomyolysis