Talk:Homologous chromosome

message: I am considering developing this page further as part of an educational assignment in Fall of 2013. If someone else is also working on this, please send me a message and let me know
soon, so we donʼt duplicate initial efforts in page development. Josemags (talk) 23:17, 6 October 2013 (UTC)
thread_title:  Untitled 

message: There seems to be a lot missing in terms of the origin of homologous chromosomes as well as their normal function. This is more like an expanded definition with out any application.
I would advise to add in more sections outlining homologous chromosomes' effects during different portions of the life cycle. Such as including portions of this article http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594255/ that describes Homologous Chromosomes movement and action during G0 phase in human cells. Josemags (talk) 00:15, 7 October 2013 (UTC)
thread_title:  Suggestions for Improvement 

message: This article will focus on defining homologous chromosomes and how they relate to a variety of biological processes. In particular, there will be sections focusing on the structure of homologous chromosomes, their chromosomal ends, centromeres, and interactive components. A following section will relate its structure to its function thereby describing uses of homologous chromosomes in a physiological setting. Topics of discussion for use are: homologous chromosome pairing, recombination, and inheritance. Our last section will cover other uses of homologous chromosomes, namely their involvement in repair of double-stranded breaks. Quigend (talk) 00:40, 23 October 2013 (UTC)
thread_title:  Summary of plan for development of page 

message: Here is a bibliography of relevant research to the topic of homologous chromosomes that will be used to help create this Wikipedia page:
Bibliography:
Alberts, Bruce, and A. Lewis. Molecular Biology of the Cell. 4th ed. New York: Garland Science, 
2002. Print.
Gerton, Jennifer L., and R. S. Hawley. "Homologous Chromosome Interactions in Meiosis: 
Diversity amidst Conservation." Nature Reviews Genetics (2005): 477-87. Web. 
<http://www.nature.com/nrg/journal/v6/n6/abs/nrg1614.html>.
Gilbert, Scott F. Developmental Biology. 6th ed. Sunderland, MA: Sinauer Associates, 2000. Print.
Klug, William S. Concepts of Genetics. Boston, Mass.: Pearson, 2012. Print.
Moulton, Glen E. The Complete Idiot's Guide to Biology. Indianapolis, IN: Alpha, 2004. Print.
Sargent R. G., Brenneman M.A., Wilson J.H. (1997) Repair of site-specific double-bond breaks in a 
mammalian chromosome by homologous and illegitimate recombination. Mol. Cell Bio., 
17(1):267.
Tissot, Robert, and Elliot Kaufman. "Chromosomal Inheritance." Human Genetics. University of Illinois 
at Chicago, n.d. Web. 14 Oct. 2013. <http://www.uic.edu/classes/bms/bms655/lesson9.html>.
Zickler D. and Kleckner N (1999) Meiotic Chromosomes: Integrating Structure and Function. 
Annual Review of Genetics, 33: 603-754. 
Austin, TX: Landes Bioscience, 2000. Madame Curie Bioscience Database. Web. 8 Oct. 2013.
"Homologous Chromosomes." - Glossary Entry. U.S. National Library of Medicine, 23 Sept. 2013. Web. 14 Oct. 2013. <http://ghr.nlm.nih.gov/glossary%3Dhomologouschromosomes>.
More sources will be added as references as the article is being written.
Stack0711 (talk) 23:45, 14 October 2013 (UTC)
thread_title:  Working Bibliography 

message: The lead sentence of the article is:Homologous chromosomes are pairs of chromosomes which contain a paternal and maternal copy. These copies have the same genes in the same locations, or loci, as one another. 
WP:SINGULAR says:Use the singular form: Article titles are generally singular in form, e.g. Horse, not Horses. Exceptions include nouns that are always in a plural form in English (e.g. scissors or trousers) and the names of classes of objects (e.g. Arabic numerals or Bantu languages). For more guidance, see Naming conventions (plurals).
WP:PLURAL says:In general only create page titles that are in the singular, unless that term is always in a plural form in English (such as scissors) or is among the exceptions such as those listed below.
So, the lead sentence defines this as a concept that only occurs in the plural (pairs), as in scissors.  Is the term homologous chromosome ever used in the singular?  If not, this article needs to be moved to the plural.  SandyGeorgia (Talk) 16:56, 16 November 2013 (UTC)
replies: text: Yes.  "Homologous chromosomes" is used more often, but "homologous chromosome" is also sometimes used.  Compare http://scholar.google.com/scholar?hl=en&q=%22homologous+chromosome%22, http://scholar.google.com/scholar?hl=en&q=%22homologous+chromosomes%22.  (As a side note, the "class" exception for WP:SINGULAR seems rather imprecise.  Protein and amino acid are certainly classes of things, but those articles' titles use the singular form.) Emw (talk) 20:45, 16 November 2013 (UTC)
thread_title:  Article title, singular or plural 

message: This is a relatively comprehensive article, especially the sections applying to meiosis. I especially found interesting the section on homologous chromosome functionality in DNA repair. There are a number of ways I think this article could be improved:
*"Intro": A clearer outline of the article's structure would be helpful to let readers know what is to come. Also, adding details regarding homologous chromosome activity throughout the cell cycle would be good. Adding some kind of interesting hook would help to compel readers to continue reading the rest of the article. In general, the intro should be fleshed out a little more.
*"Structure": If you can find one, I would suggest adding a picture depicting the centromere locations you mentioned to help clarify the different positions. 
*"In humans": In order to rid the article of any kind of bias, the words "our" and "we" ought to be discarded from the last part of the section.
*"In meiosis": remove duplicate reference to Creighton and McClintock's work with corn chromosomes.
*"Prophase I": There seems to be too much information about the synaptoneural complex, which itself might be more applicable to the anaphase section of the article. Clearer sentences describing the steps of this process would help the section be more understandable to the average reader. Again, removing the unnecessary duplicate reference to Creighton and McClintock's work would improve the section. 
*"Anaphase I": Remove the duplicate reference.
*"Nondisjunction": Trisomy and monosomy are not defined as the presence of either three or one chromosome(s) in the zygote, as if the zygote only has three or one chromosome(s). Instead, trisomy and monosomy refer to an additional two chromosomes or one less chromosome in the zygote compared to the normal zygote.
*"Embryonic death": Including this section in the Nondisjunction section would be appropriate given the overlap of information.
*"Other uses": I found this to be the most intriguing section of the article. The paragraph could be written more clearly though, especially regarding the steps involved in homologous chromosome repair of DNA.
In addition to these improvements, balancing the heavily meiosis-detailed information in the article with other material concerning mitosis would be good. Furthermore, if there is any current research going on involving homologous chromosomes that could illuminate possible discoveries, adding those experiments to the article would be beneficial.
Slj758 (talk) 00:39, 23 November 2013 (UTC)
thread_title:  Article Review 

message: First of all, nice job on the article overall! I think the introduction provides a good general idea into the topic and adding a karyogram picture was a good idea. However, it will be better if a little more detail on Gregor Mendel’s law is added (even though it’s provided in structure section- so that readers don’t have to scroll all the way down). In the overview section, it would provide the readers with more clear understanding if some details on how chromosomes interact (crossing over, etc), not just a description that says it can be affected by crossing over. History section can be improved if some background info on how the studies were done is added (or perhaps some pictures showing experiment results). For structure section, it will provide the readers with better understanding if picture/description on four different centromere placement arrangements is added (metacentric, submetacentric, telocentric, or acrocentric – how their structure differs from each other). This is just a suggestion- for functions/ problems part, it may be great if some information on how genetic mutations can affect the segregation of homologous chromosomes during meiosis/mitosis and/or pairing of homologous chromosomes prior to separation. In addition, it would be better if more details on how homologous chromosomes work in mitosis- article is heavily based on meiosis. This is minor but- for other uses section, readers will get more clear understanding if a picture or more clear descriptions on how chromosome repair process works (such as what kind of proteins involved, etc). Great job guys, the article in general provides good details and information on homologous chromosomes. Kohw 12:04, 23 November 2013 (UTC)
thread_title:  Peer Article Review 

message: Nice job on the article! I think that the layout is logical and that there is a good flow of material. I especially liked the Functions sections, which I thought provided great detail on the role of chromosomes in Meiosis. I do have some suggestions: 
	The article introduction seems brief. I think it would be appropriate to generalize some of the topics you cover later in the page, such as history of discovery of homologous chromosomes and problems (ie. nondisjuction.) The Overview paragraph is a little redundant and could be consolidated into the introduction. I also noticed that there are inline citations in the introductory paragraph. Now I’m not sure if this is an official Wikipedia rule or not, but in general article introductions do not have inline citations in their first paragraph. I think that the specific material that you cite in the introduction is general enough that you do not need to cite it. That might be something to ask Keilana or our professor about. 
	I think it would also be helpful to write a little more on the distinction between sister chromatids and homologous chromosomes in the structure paragraph. Some molecular biology is relevant here as well too. It is not explicitly stated that chromosomes are condensed DNA. While some of this material may overlap with the chromosome Wikipedia page I think it is helpful in understanding the concepts in this page as well. Perhaps also talk about karyograms and being able to visualize condensed chromatin (homologous chromosomes) in cells. One last small comment, but for the in humans subsection, I don’t think you should use the personal plural subject (we/our) in this sentence: “So humans have two homologous chromosome sets in each of our cells, meaning we are diploid organisms.” I didn't see other personal pronouns in the article but I would avoid their usage.
Overall I thought the page was appropriate in style and content to other Wikipedia articles, and I also appreciated the pictures that were included. NJSfour (talk) 23:41, 22 November 2013 (UTC)
thread_title: Peer article review

message: Is the reference to mitosis in the introductory paragraph correct? Should it refer to meiosis?  — Preceding unsigned comment added by EBT111 (talk • contribs) 21:03, 14 February 2015 (UTC)
thread_title:  First paragraph possible error 

message: Substituted at 18:12, 29 April 2016 (UTC)
thread_title: Assessment comment