Talk:Bupropion/Archive 1

message: This sentance is a little suspect; "psychic energy"?:
::Because patients with suicidal thoughts suffering from depression may experience a serious increase of psychic energy before remission of depression is encountered, these patients are at high risk of attempting suicide. If one decides to treat these patients with Bupropion, sedative drugs (benzodiazepines or Chlorprothixene) should be given additionally until remission of depressive disorder occurs.
24.31.191.41
:I'll have a look. JFW | T@lk 19:38, 6 November 2005 (UTC)
thread_title: Psychic energy

message: I've been on Wellbutrin XL 300mg for severe depression for over a year now.  It seems to have an altering effect on what happens after I smoke pot.  It enhances the euphoric feeling (described best as "floating") but occasionally gives me a rush of several mixed feelings all at once (happiness, saddness, agitation, the desire for tranquility, and fear [rarely]).  My high also seems to be drawn out longer than smoking when I wasn't on Wellbutrin.
I've also had moments where I would be looking at something (such as a trail in a forest I was walking in) and it would trigger whole dreams to be replayed crystal-clear in my mind.  The "something" also had a significant role in the dream, which is why I think it triggered these relapses. The dreams weren't even from recent times, either. All of the dreams I've had relapses of were from my childhood (like second grade) that had long since been forgotten.  I usually feel overjoyed after remembering this or that dream.
I remember one time I even had auditory hallucinations right after smoking of a cat meowing and a dog barking from far away in my right ear and indoor laughter in my left ear, which lasted for about 10 minutes.  It was strange because I was out at a park and nobody else was in the park aside from the two friends I had been walking with.
The only bad experience I've had has only occured a few times.  It's a barrage of ideas, memories, and feelings all at once for about an hour or two.  This is basically like an overload of my mind, and the only way I've delt with it is just to ride it through until my high is over.
A few people I know who have/had also been on Wellbutrin seem to describe the same types of things, but everything is subjective and varies a little from person to person.
The resulting psychological effect of mixing Wellbutrin with pot is now referred to by myself and my friends as "Wellbutripping."  We hope this will catch on sooner or later :)
I didn't know where I could enter all of this on the article since it's subjective.  Just thought I'd add my two cents to the discussion.
Kokekane9 19:17, 11 January 2006 (UTC)
replies: text: Interesting experience. Perhaps submit to erowid.org ? --Pfh 01:59, 21 January 2006 (UTC)
replies: text: Hookah smoking is much more pleasurable I've found since I've been on this.J. M. 21:04, 5 April 2006 (UTC)
thread_title:  Wellbutrin + Pot 

message: When commenting on the references, please keep commentary to the actual findings reported in the references. In the study on sudden death and bupropion: The conclusion of the general practice case series study states: “bupropion is probably associated with a small increase in seizure rate, which is similar to that seen with most other antidepressants when used to treat depression, but there is no evidence to suggest that the drug is associated with an increased risk of sudden death, and our findings suggest that a hesitancy to use the drug on these grounds is unfounded.” It does not comment on risk of suicide - with a series of 9329 patients it would be notable if any had taken their own life whether using the drug at the time or not. ie The study was not designed to determine risk of suicide - so it cannot say there was an increased risk of suicide (just as it cannot say there was no increase ). Nogwa 13:37, 20 August 2006 (UTC)
thread_title:  Risks in tobacco withdrawal 

message: judging by the other entries, this site is not used as a tool to assist foreign police forces, is this the case, I do not live in a Western nation. will information raised here be treated confidentially.
:No, information here will not be treated confidentially by any stretch of the imagination.
:Zuiram 02:24, 27 October 2006 (UTC)
thread_title:  Methylphenidate Hydrochloride and wellbutrin sr ?????? high usage 

message: Im currently taking Wellbutrin XL 150mg and have been doing so for about 3 months.  Im also taking Lexapro as well and have been on that for about 4 years.  I was wondering what the interactions between these two drugs might be?  I had each one prescribed by a different doctor because I moved off to college last year.
I was wondering where I could find out about the interactions of the two drugs.  I was taking Lexapro for Depression and Anxiety and Wellbutrin seems to cause Anixiety(based on info from this article) so Im not sure its it being used as it should. 
Ok, now for my side effects:
I can vouch for the insomnia.  I am up all night every night.  Even when I am dead tired.  Of course I do have Afternoon classes and wake up at 11am, but Im often up from 2pm til 7am on a regular basis. My sleeping schedule has become very sporatic.  Like today, for example, I was up last night from 9pm until 3pm.  Then I slept until 1am.  And now I am up and it is 3am EST right now. The sweating definitely happens as well.  I occasionally(maybe 3-4 times a week) wake up in the middle of the night with sweats.  And after I wake up my hands become covered with perspiration to the point that it can (and will) actually drip from my hands.  I also have a tendency to feel dizzy and have fainting spells (possibly as a result of Lexapro; its page is not very informative) and I dont know if this is increased by this combination of drugs or not.
I occasionally take Excedrin or Advil for headaches and for the last ten days Ive been taking Sudafed and Amoxiclav for a Sinus/Ear infection.  There have been no other drugs used by myself since starting Wellbutrin XL.
Yes, but I was wondering where I might find information about these two drugs and their relations because I have failed to find it through google and am once again coming to Wikipedia for rescuing.
Thanks,
Lamentingvampire09 08:18, 4 November 2006 (UTC)
thread_title: My experiences with the drug and some questions

message: I just wanted to chime in, that while I was taking this evil (imho) drug for depression (under the care of a doctor), I experienced extremely psychotic dreams, to the point of shooting, without emotion, 2 of my closest friends in said dreams.
I may also mention, that a friend of mine, taking the same drug at the same time, with the intention of quitting smoking (under a different doctor's care also) did litterally attempt to strangle his wife (fully conscious event).
And then, I ran out of money, 2 months into using this drug, and the co-pay didn't pan out. I was unable to obtain a refill, and thus forced to stop "cold-turkey". The effect of this, for me personally, was EXTREME depression, with suicidal thoughts. To sum up my feelings, it felt like every atom of the universe harbored a strong hatred of me, and wished me to become non-existant. Perhaps this sudden removal is what triggers the suicidal tendencies of other patients, especially in the case of juveniles who fake taking the drug as a rebellious action against authority (I know I did the same with the Obatan Forte (now banned, alike adverse side effects) that was being foisted on me as a child for hyperactivity, some 25-30 years ago). Then again there may be other reasons.
I just hope anyone who is considering using Welbutrin/Bupropion reads this, and considers their lot first, and may ask their doctor for an alternative. And to those of you who are facing sudden withdrawl, or are now worried about withdrawl... well, the vile effects are extreme for the first day, and are gone in three days (at least for me they were). Just hold on, it's not going to be fun, and cling to your logic.
Zaphod
http://zaphodb.dyndns.org —The preceding unsigned comment was added by 69.145.40.116 (talk • contribs).
:Quite honestly, what you've said here sounds no more than trying to scare people into not taking Wellbutrin without realising obvious things like: Not all drugs are for all people. I believe that my HMO generally puts people on Prozac as the first try for anti-depressants if there's no reason not to. Prozac did not work for me, but I'm never going to tell anyone that they shouldn't take it because they "will" have trouble with the side effects I had trouble with (no sex drive, insomnia/horrible sleeping patterns). However, I then learned that my family has a good history with Wellbutrin, although my father had experienced an unacceptable level of feeling cotton-headed and thus no longer takes it, while my grandmother continues to take 300mg daily. I switched to Wellbutrin as soon as I possibly could and I've enjoyed some of the more positive side effects (quitting smoking was damn easy and sexual activity is far more entertaining), as well as working very well for its prescribed usage.
:The suicidal tendencies in the younger set who are prescribed any anti-depressant, not just Wellbutrin, is generally attributed to the fact that the drug "fixes" them enough that they have energy to be active again, but that their way of thinking has not yet changed, thus they now have the energy to carry out suicidal plans.
:Also, again you have spoken without researching: Quitting any anti-depressant cold-turkey is going to screw you over. Anti-depressants affect your brain's chemistry, which is why patients are started at low dosages and moved up to a full dosage and then the same is done in reverse when getting off of the drug. I can entirely relate that Wellbutrin withdrawal isn't fun (I've forgotten to take all of my doses or take it at all) and I'm hoping my refill arrives soon, before I run out, and that I can step back up to my normal dosage.
:Taking any drug without being fully aware of the side effects is stupid and no doctor should prescribe any drug without fully discussing the side effects with the patient, including what to do if some of the drug's nastier side effects are encountered.
:128.153.197.122 03:42, 13 December 2006 (UTC)
replies: text: Forgive me for being devil's advocate, but why are people posting experiences? Isn't wikipedia not experience based?--69.251.145.233 00:23, 2 January 2007 (UTC)
replies: text: The above comment was made by me, i forgot to login.--Neur0tikX .talk 00:24, 2 January 2007 (UTC)
thread_title:  My experience with Welbutrin. 

message: I'm curious where the information on the dosage forms came from, because the Wellbutrin I was prescribed does not fall into any of what is mentioned (my prescription is Wellbutrin SR, 100mg, manufactured by Watson, imprint code WPI-858). Any reference/citation anywhere for that? 128.153.197.122 04:09, 13 December 2006 (UTC)
thread_title:  Dosage? 

message: I have marked that the page Budeprion SR should be merged here and a redirect set. Master shepherd 17:36, 25 December 2006 (UTC)
thread_title: Budeprion SR Merge

message: I tried an average dose of what I knew to be pure MDMA. All my friends "Rolled" But I did not. I take 300mg of Welbutrin XL daily. PErhaps they bind to the same receptor sites. —The preceding unsigned comment was added by 72.94.6.82 (talk) 06:04, 20 December 2006 (UTC)
replies: text: Most likely, no. It's unlikely as Wellbutrin focuses more on the catecholamine reuptake, not serotonin. Although, if you happen to take antipsychotics such as seroquel or rohypnol it's likely that they interfered with your 'roll', so to speak. Of course, the culprit could be something completely nonpharmaceutical, MDMA interacts with the brain in a very specific way, hence, a roll can be offset by a number of things, as well as a trip. The antipsychotics also interfere with most 'trips', I believe some antipsychotics/neuroleptics are even given to persons who experience a bad trip as they interfere with the many receptors that LSD decides to erratically act on.--Neur0tikX .talk 00:29, 2 January 2007 (UTC)
thread_title:  Bupropion and MDMA 

message: http://www.antidepressantsfacts.com/Bupropion-not-prescribed-in-France.htm
Sentence I'm removing: Wellbutrin is also banned or restricted from use in several countries.
This is the only reference I have found to Wellbutrin/Zyban being banned.. anywhere.  And that's not a ban.  That's France recommending it not be prescribed as an anti-smoking agent.  Not only is a reference needed to make that claim, but the only hint of a reference seems to suggest otherwise.  A great many sites -claim- that it is banned, but no reputable sources do, nor can I find a list of countries to suggest such.  Until I see something legal and/or legitimate, I am removing this sentence. AltonBrownFTW 04:35, 10 March 2007 (UTC)
thread_title:  Supposed Banning 

message: I recently started taking bupropion (Wellbutrin XL in fact) and one of the major items listed about it in the documentation I was given by my pharmacist was to avoid the use of alcohol.  There is little about this in the article here however and alcohol isn't even listed in the "Contraindications" section.  Perhaps it should be?
-- UniqueCrash5 17:04, 5 April 2007 (UTC)
thread_title:  Alcohol interactions 

message: In Germany Amphetamines are forbitten, so would Wellbutrin be a possible medication against ADHD? --134.155.99.42 12:40, 9 May 2007 (UTC)
thread_title:  Does it help against [[ADHD]]? 

message: IMHO one of them should be removed, I do not care which.Paul gene 22:12, 9 May 2007 (UTC)
replies: text: Well, the article is quite long, and images help break up the text a bit. If you feel one is redundant to the other I'd suggest keeping the space-filling model in the Drugbox and removing the second one. Fvasconcellos (t·c) 03:59, 10 May 2007 (UTC)
thread_title:  Do we need to have two 3-d pictures? 

message: I'm thinking of trying it for sex dysfunction that I get from from my anti-psychotics. Has anyone else had it work as an augmentation to their other drugs and treat the sex dysfunction from the other drugs at the same time. I couldn't find any other studies that supported these claims, but I'm going to try it based on this. Especially if it makes me give up smoking, gives me energy, and makes me happy all from one pill. Sounds like a bit of a wonder drug. But as I said I"m mainly after it for the female sex dysfunction thing. It's not papproved for any of these uses in my country, not even an nati-depressent but I'll pay I suppose...
Also there was something about it treating schizo-affective dissorder - isn't that really similar to schizophrenia, does anyone know what it's effects are on schizophrenia aside from being recommended for their chronic smoking habits? I'd like to see more info on this and more back up for the sex dysfunction claims - I can't find one other site that supports this claim or says it's any better than the placebo - however I'll let the whole world know witha loud sexy scream if it works on me as I've been tolerating this problem from my anti-psy's for a long time. 
--121.210.90.95 10:41, 20 June 2007 (UTC)
thread_title:  bupropion and sex dysfunction.  

message: Well I got hold of some bupropion. And almost immediately it does indeed seem to be curing my sex dysfunction which is caused by the haloperidol I'm taking. For the first time in almost four years I am having physical sexual sensations again. It also gives me a little lift in spirits and wakefulness I think which is also good for cancelling out side effects from haloperidol. I've got my fingers crossed I can remain on it and it can pose the long term solution as I have a necessity to take the haloperidol really. Other anti psychotics are just as bad or worse than haloparediol in terms of side effects and out of all of them it's most suited, but the sex dysfunction was the bain of my existence. Currently thinking bupropion is the next best thing since sliced bread and will update this in a few weeks to say whether it seems to be still having the positive effects and that it hasn't posed heart problems skin rashes or any other side effects that prevent me being able to have it. It's $75.00 per month but I'm worth it! I mean it's a shame to have to take psychiatric drugs at all but as far as they go I am pretty tolerant of bupropion so far. Sex functioning is just a little pleasure even alone in private, which you don't want to give up when you're already having a hard time with health issues, and to me may well mean the difference between seeking out a bf in life or being almost completely socially isolated and lonely. I had really serious impotence and it's like having a whole other dimension of experience back again. I don't mean to sound like an advert but more women and possibly men with sex dysfunction need to try this drug to test if it can help them too. This drug has been around the whole time I've had this problem and I wish I'd known about it before. As it was I found the answer on here and had to suggest to my sex physician to prescribe it to me. In a few weeks once I can base it upon a fair trial I'm going to tell her the good news and perhaps she can help more people with it too. As I may be the first person whose tried it for this purpose in Australia I think. Thumbs up so far so good. Looking forward to more good news about this drug hopefully. Thank you for the info wikipedia. Still wanting more info on it's effects on schizophrenia, as I noticed it is being researched for schizo affective disorder which is pretty similar isn't it to schizophrenia, it'd be great if it even became the one drug I needed to take for all my problems as it's just more pleasant than the anti-psy's. 
Purrin
--121.210.91.91 01:32, 12 July 2007 (UTC)
thread_title:  bupropion and sex dysfunction #2 

message: It would be great if someone with access to the full text of  and  could have a read. The first, particularly, appears to be a landmark article regarding the incidence of seizures with bupropion treatment and how it relates to dosage, and both could be used to cite the History section. Fvasconcellos (t·c) 15:58, 18 August 2007 (UTC)
replies: text: OK, thanks. Fvasconcellos (t·c) 00:33, 19 August 2007 (UTC)
thread_title: Request

message: The intro of this article says:
"marketed as Wellbutrin, Zyban, Voxra, Budeprion, Prexaton or Aplenzin;"
Why is there no mention of "Elontril" considering that there is a big market in Germany, whereas "Voxra" (Finland and Sweden) is included here?  — Preceding unsigned comment added by 84.58.239.29 (talk) 11:47, 16 September 2012 (UTC)
thread_title: Why just these brand names?

message: The unnecessary inclusion of dosage, adverse effects and availability information overloads the lead part. It also repeats the corresponding parts of the article. I suggest removing the following from the lead:
"In the United Kingdom and Australia, it is only licenced to assist in its cessation of smoking function. The regular dose for treatment and maintenance therapy in clinical depression is 300 mg daily, though doses of up to 450 mg daily may be prescribed by a physician. 150 mg is the daily dose used in the treatment of nicotine dependence.
Common adverse effects include dry mouth, nausea, insomnia, tremor, excessive sweating and tinnitus. Rarer but more serious is the potential for seizures as bupropion lowers seizure threshold and thus caution is advised in situations where they are more likely to occur. Bupropion is not considered dependence-forming, nor is there evidence of increased suicidal behaviour occurring with its use."Paul gene 18:35, 18 August 2007 (UTC)
replies: text: Paul - the reason I put it in is that the lead is supposed to summarise the salient points of the article - i.e. you could have a quick squiz at the lead and see all you needed to know of high importance at a glance. Most articles at FAC have this approach and I fear that if shortened again there will be a cry for a longer one. I've not been on this article long but it is a tricky one to fingure what should go where in places :) cheers,  Casliber (talk · contribs) 22:27, 18 August 2007 (UTC)
replies: text: I don't have strong opinions on it either way really so we'll see how it flies..cheers,  Casliber (talk · contribs) 13:07, 19 August 2007 (UTC)
thread_title:  Make the lead part shorter 

message: I suggest removing the Australia part from the following sentence in the History: "In the United Kingdom, bupropion was approved as a smoking cessation aid in 2000, but has not been approved for the treatment of depression;[7] a similar situation exists in Australia." Until somebody finds the reference.Paul gene 18:37, 18 August 2007 (UTC)
replies: text: I am sorry I didn't get the ref right off but it was late and I was tired. Also I am busy off-keyboard for alot of today. I left it there as there needs to be some global summary of how it is used elsewhere - thus mention of use of other countries will need to be reffed and included prior to FAC being successful  - otherwise the article is USA-centric. I'll put a fact tag on it until thencheers,  Casliber (talk · contribs) 22:30, 18 August 2007 (UTC)
thread_title:  Indications for Australia 

message: I've boldly shifted the sections around for better compliance with WP:MEDMOS. As a guideline, MEDMOS is not set in stone, but I do think the article flows better now. If anyone wishes to revert and discuss, please do! Fvasconcellos (t·c) 01:06, 19 August 2007 (UTC)
replies: text: I moved the 'abuse liability' section down to the bottom, as I feel that there are other sections, like 'mechanism of action' and 'pharmacokinetics', are more important. I also moved the 'overdose' information out of its own section and back into the 'dosage and forms' section, as it really falls under that section. There's no reason for it to be separate. Plus, having several sections in between 'dosage' and 'overdose' really doesn't make sense at all. Yes, I am aware that there is an 'overdose' section in the medical MOS, but I feel that that is an error; (a) there's no section there called 'dosage' or 'dose', just overdose; (b) I think that the order of the sections that they are suggesting for drug articles could be improved. I'll look at this more later, but I would suggest revising the manual of style, at a minimum, to change 'overdose' to 'dose' or 'dosage'. Dr. Cash 07:25, 19 August 2007 (UTC)
replies: text: Agree with both above. cheers,  Casliber (talk · contribs) 07:49, 19 August 2007 (UTC)
replies: text: Well, there has been some discussion re. not allowing dosage information to be included at all, as it is easily subject to uninformed good-faith edits; MEDMOS currently discourages adding such information altogether. I agree that may be excessive, but this should probably be taken up at the guideline Talk page. Fvasconcellos (t·c) 13:34, 19 August 2007 (UTC)
thread_title:  [[WP:MEDMOS]] 

message: Would anyone object to the "Trade names" section being renamed "Availability" so we can expand a bit with licensing/history information from other countries? Fvasconcellos (t·c) 13:49, 19 August 2007 (UTC)
replies: text: Hmm, on having second thoughts of the dosage/overdose issue which I reverted, I started thinking about the dose issue per WP:MEDMOS. One of the possibilities I thought of myself was renaming the section to something like 'availability' (merging 'dosage and forms' and 'trade names'), so as to primarily cover the different forms and brands covered and such. Then, the 'overdose' information could be moved into its own section. Dr. Cash 19:53, 19 August 2007 (UTC)
replies: text: I've just moved this content, merged with 'trade names', and re-created the 'overdose' section. Still uncertain specifically where to put 'overdose' -- for now, I put it after 'adverse effects', but I'm open to suggestions here. Dr. Cash 20:08, 19 August 2007 (UTC)
replies: text: Looks good. I'll move some of the "History" content into "Availability" and see if I can get some more international information. Fvasconcellos (t·c) 20:09, 19 August 2007 (UTC)
thread_title:  Trade names 

message: I've removed the following two links from the external links section of the article:
* http://www.quitsmoking-review.com/
* Quit Smoking Pills
They're largely redundant, and talk more about quitting smoking than bupropion itself. Plus, it really borders on linkspam. This article is about the drug bupropion, which does have one effect of lowering the urge to smoke, but it's still not about 'quitting smoking', so these links are irrelevant. Dr. Cash 16:48, 21 August 2007 (UTC)
replies: text: Agreed. Fvasconcellos (t·c) 16:52, 21 August 2007 (UTC)

text: I'm sorry, but I have seen these specific two links (saw them back in August as well) and I really don't think they are helpful; that is, I don't think they add anything to the article. Besides, they provide links to objectionable commercial websites (online pharmacies). Fvasconcellos (t·c) 01:15, 22 December 2007 (UTC)
thread_title: external links

message: I suggest removing the paragraph about bupropion possibly causing the tics in children with ADHD and Tourette's and adding the ref that bupropion is not efficacious for ADHD. The paragraph in question contains information which pertains to the cases which are very unlikely to happen for the following reasons:
Tics have been reported only in children treated with bupropion for ADHD, not in adults. Bupropion should not be used in children. Since 2004, it is not simply an off-label use, it is the use of the drug in a population where it is contraindicated. While it is possible that a very small number of psychiatrists would still use bupropion in children with depression as a drug of the last resort, it is inconceivable and highly improbable that anyone would use it for ADHD in children, since bupropion’s efficacy in children with ADHD has not been demonstrated. (In the largest double-blind study conducted bupropion was not better than placebo, for the review see ). Thus, bupropion for ADHD in children is in no way a common off-label use, and the issue of tics in children is moot, and just takes room and distracts the reader.Paul gene 01:50, 27 August 2007 (UTC)
replies: text: The cited article (2007, not the 1993 case series) claims that bupropion is a third-line agent in the treatment of ADHD, and (perhaps in Europe) should not be ruled out as therapy for ADHD in children when other approaches have failed. Maybe outside the U.S. this is indeed simply off-label use? Should it be included in some other article? Fvasconcellos (t·c) 02:05, 27 August 2007 (UTC)
replies: text: Do you mean - Poncin Y, Sukhodolsky DG, McGuire J, Scahill L (2007). "Drug and non-drug treatments of children with ADHD and tic disorders"? No, those guys are Americans; did not you notice that, at least judging by the slow approvals of bupropion, Europeans are much more skeptical about it. The fact that bupropion makes teenagers with ADHD to take on smoking makes its use in them even more inconceivable. Can you imagine a child psychiatrist, who knows all of the above, in his right mind prescribing something clearly contraindicated for a disorder that is not critical for the health and wellbeing? Think lost malpractice lawsuit if the patient starts smoking. My guess would be that the authors used some older pre-2004 review or guidelines. Are you sure that the paper said third-line treatment for ADHD in children? Because in adults with ADHD bupropion is legit. Unfortunately, I have access to that journal with the 12-month delay. Do you care to drop an extended citation on my user page? When you ask, Should it be included in some other article? - do you mean the paragraph about bupropion possibly causing the tics in children with ADHD and Tourette's? Maybe to Tourette's... But will moving it make it more relevant? It will still be informational junk.Paul gene 02:44, 27 August 2007 (UTC)
replies: text: FVasconcellos gave me the quote from the above reference: "In the absence of placebo-controlled data to confirm the attribution of tics to bupropion exposure, the use of bupropion with appropriate monitoring in children with ADHD and tics deserves consideration if other approaches have not been successful." So it looks like I was wrong - psychiatrists are willing to consider bupropion as the drug of last resort for the ADHD in children.Paul gene 00:33, 30 August 2007 (UTC)
thread_title:  Remove tics in children with ADHD add not efficacious for children with ADHD 

message: Wellbutrin XL is available in the US as a generic formulation, for example, as Buproprion XL. See any pharmacy store, or drugstore.com onlinePaul gene 00:43, 30 August 2007 (UTC)
replies: text: Nice catch. Fvasconcellos (t·c) 00:44, 30 August 2007 (UTC)
thread_title:  Wellbutrin XL is available in the US as a generic formulation 

message: Why doesn't the article summary on the main page make any reference to the trade name Wellbutrin? People would be much more likely to read the article if it was clear that bupropion was the chemical name of Wellbutrin. Fuzzform (talk) 01:02, 21 December 2007 (UTC)
replies: text: The problem with such a suggestion is that it appears the name Wellbutrin is not universal with different names such as Zyban being used by GSK in different countries. Furthermore it appears that bupropion has been out long enough that patent protection is no longer available and there are therefore numerous generics. Also, unlike say for example prozac where the drug became so popular that it is generally recognised under its tradename and not that of any of its generics it's not clear this is the case for bupropion. We will at the very least have to give the names  "Wellbutrin, Zyban, Buproprion and Buproban" as in the article but even that may not be enough IMHO. Nil Einne (talk) 04:39, 21 December 2007 (UTC)
replies: text: I asked on the Wikipedia:Main Page/Errors to put the two most widely known (Wellbutrin, Zyban) tradenames back into the summary. Please support me. Paul gene (talk) 11:17, 21 December 2007 (UTC)
thread_title:  Mainpage article 

message: A heading should be added to the main page with regard to what is refered to as "discontinuation symptoms" which is a phrase used by the unscrupulous prescribers to avoid the implication of the addictive potential of these drugs. These drugs are highly addictive with sever withdrawal symptoms and the general public is not aware this until they choose to discontinue the drug.  —Preceding unsigned comment added by 97.88.205.124 (talk) 17:57, 21 December 2007 (UTC)
replies: text:  No they are not addictive at all let alone highly addictive. You are the kind of person who's ignorance makes wikipedia only good as a jumping off point on a subject but overall a terrible source of actual information if you want it to be correct.  — Preceding unsigned comment added by 68.36.10.247 (talk) 01:01, 10 September 2014 (UTC)
thread_title:  nsri and ssri addiction 

message: At the end of the first paragraph of Adverse Effects it currently reads "The development of mild to moderate skin rashes is associated with sensitivity to dye components within the pill coating. This can often be alleviated simply by prescribing a differently colored pill.[52]". The current (August 2007) version of the Prescribing Information document that the #52 reference points to does not mention this coating alternative. Can anyone provide another reference supporting this statement? Thank you.  2old (talk) 23:03, 9 January 2008 (UTC)
thread_title:  Pill Coating in Adverse Effects section 

message: I just have a little question, if bupropion is used as a smoking cessation aid because it produces the same effects or provides the same feeling as nicotine, stimulates the same receptors - gives the same hit - would that not make it highly addictive? I'm looking at my options for quitting smoking and have found the article and the discussion group very helpful. ~ 20th February 2008  —Preceding unsigned comment added by 146.171.254.66 (talk) 22:16, 19 February 2008 (UTC)
thread_title:  smoking cessation 

message: Re the claim that "Bupropion does not affect any measures of sexual functioning in healthy men":
"In the men, significant improvements over baseline (p < .01) were observed with both doses in overall sexual satisfaction, ability to achieve an erection, and delay in reaching orgasm/ejaculation; significant improvements relative to placebo (p < .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration"
Source:
Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: a pilot study. Modell JG, May RS, Katholi CR.
Department of Psychiatry, University of Alabama at Birmingham, USA. 
jgmodell@uab.edu 
http://www.ncbi.nlm.nih.gov/pubmed/10929571
If you believe the Salon.com account at 
http://archive.salon.com/sex/feature/2000/09/26/wellbutrin/print.html
there is an interesting story behind the lack of publicity concerning the sexual side effects of Bupropion. 
66.217.83.176 (talk) 04:04, 15 September 2008 (UTC)
replies: text: The example you have given pertains to "men with orgasmic dysfunction" not healthy men. The statement in the article :"Bupropion does not affect any measures of sexual functioning in healthy men" Paul Gene (talk) 01:30, 17 September 2008 (UTC)
replies: text:  Every other part of the section talks about sexual dysfunction, and suddenly, right after a passage about sexual dysfunction in women, a statement out of the blue about healthy men is tacked on, giving the distinct impression that it is to be contrasted with the previous material about women.  That's misleading, even if factually true. 66.217.82.160 (talk) 17:20, 1 October 2008 (UTC)
thread_title:  Sexual functioning in men 

message: I went on Zyban last year to stop smoking. Before I went on it people had told me I might get nightmares (including my doctor). I shrugged it off and did not think anything of it. When I went on the drug I did experience some pretty messed up dreams. After talking to others who have taken the drug, it seems that everyone on it experiences crazy nightmares. This aspect should be included in the side-effects section.  —Preceding unsigned comment added by 24.150.147.192 (talk) 05:46, 12 April 2009 (UTC)
thread_title:  Nightmares 

message: The article should not mention bupropion as TNF-alpha inhibitor for the following reasons:
* Bupropion is not a TNF inhibitor. In order to be classed as a TNF-alpha inhibitor the compound should bind to and inhibit TNF-alpha receptors. Bupropion does not do that according to the provided reference (). It decreased TNF synthesis via stimulation of the adrenaline and dopamine pathways.
* The study findings are not relevant to humans. The provided reference is a study in mice. There have been no studies of TNF-related or anti-inflammatory activity of bupropion in humans. Since metabolism of bupropion in humans and mice is very different, the relevance of these findings is questionable.
* Not notable. There are more than 2000 scientific papers on bupropion in PubMed. This single unconfirmed animal study is simply not notable enough to be included.
The Sceptical Chymist (talk) 11:31, 10 May 2009 (UTC)
replies: text: One more example of the problems caused by not following WP:MEDRS.  This article has probably 10 times as many sources as it ought to, because it relies on primary reports rather than review papers.  Once you start admitting primary sources, it's very difficult to draw a line. Looie496 (talk) 16:04, 10 May 2009 (UTC)

text: this isn't a case if a single unconfirmed animal study.Did you even do a google search? There are many articles, on TNF and Buproprion.  I used this reference, because it was the one used in the article TNF inhibitor.  Here are just a few of the others, you can find many more: , ,,, ... MistyWillows talk 17:42, 10 May 2009 (UTC)
replies: text:  RE: Looie496. Who cares about WP:MEDRS. The policy WP:NOR overrules WP:MEDRS, which is a mere guideline. The policy WP:NOR allows primary sources for descriptive claims. The Sceptical Chymist (talk) 21:53, 10 May 2009 (UTC)

text:  RE: Misty Willows. I apologize. Bupropion, indeed, have been used in humans with autoinflammatory diseases. Please go ahead and insert your references. However, although bupropion decreases the level of TNF alpha, it is not TNF-alpha inhibitor. And none of the articles you quoted says so. The Sceptical Chymist (talk) 21:53, 10 May 2009 (UTC)
replies: text: The article  TNF inhibitor lists bupropion, and it was added there by a doctor. ... MistyWillows talk 23:51, 17 May 2009 (UTC)
thread_title:  TNF-alpha inhibition 

message: Hi 
I'm not up to speed on making changes to these pages, but maybe someone else can.
I found another page that should be linked to from this page.  It is
http://en.wikipedia.org/wiki/Buproprion
Thanks
Marty  —Preceding unsigned comment added by 76.21.91.99 (talk) 03:12, 20 June 2009 (UTC)
replies: text: . Fvasconcellos (t·c) 23:34, 26 June 2009 (UTC)
thread_title:  New Link 

message: Okay, this I don't get...Casliber (talk · contribs) 11:22, 26 June 2009 (UTC)
replies: text: WP:CHEM no longer accept FA-Class as part of their assessment schems, which now appears to be focused on the actual chemistry part of articles (e.g. a drug article may be FA, but if it doesn't go into much detail on chemistry, it will be B- or C-Class, etc.). Fvasconcellos (t·c) 23:51, 26 June 2009 (UTC)
thread_title: Rating templates?

message: Am I crazy, or is the chlorine atom in the structural diagram in a different position on the phenyl group than it is in the 3-d picture right below it? 67.176.82.104 (talk) 18:51, 30 July 2009 (UTC)
replies: text: The two diagrams are the same structure, but of different conformations. The ring is a regular hexagon that can rotate as a unit relative to the carbonyl. In both structures, the chlorine is attached ortho ("2 positions away", with one hydrogen position between them) relative to where the carbonyl is attached. DMacks (talk) 20:14, 30 July 2009 (UTC)
replies: text: The two diagrams represent the same structure, at least as far as the phenyl ring is concerned. The 3-D representation can only show one enantiomer (the one shown is the (S)-enantiomer), whereas the line diagram represents a mixture of the two. DMacks, I know you know better, the chlorine is attached meta to the carbonyl ("2 positions away", with one hydrogen position between them) in both cases! Physchim62 (talk) 20:55, 30 July 2009 (UTC)
replies: text: Well crap, that's what I get for responding before coffee kicks in. *blush*:( DMacks (talk) 21:06, 30 July 2009 (UTC)
replies: text: Yeah, the chlorine is still meta relative to the carbonyl. My issue with the new structural diagram is it's colored. Why is that? Seemed like someone had too much time on their hands and edited the previous bupropion structure (which I might add, had the chlorine in the other meta position, consistent with the 3D graphic)from a fine black and white representation to some artsy crap. I personally think it should be reverted back to its prior version so that it's #1 consistent with the 3D graphic (to avoid confusion such as the original poster pointed out) and #2 consistent with all other structural diagrams on pharmaceutical and chemical structures. --Novaprospekt (talk) 21:59, 14 August 2009 (UTC)
thread_title:  Structural diagram vs. Image 

message: The last sentence of the opening section that says "In contrast to many psychiatric drugs, including nearly all antidepressants, bupropion does not cause weight gain or sexual dysfunction."-- shouldn't this require a source? I take bupropion and it certainly has made me LOSE weight and actually made me enjoy sex more (in great contrast to the SSRI's I used to be on-- yuck) but this seems like a big claim that should have a source to back it up. What do you guys think? --Novaprospekt (talk) 03:58, 7 August 2009 (UTC)
thread_title: No weight gain/sex dysfunction claim

message: I would like to include an article in Bupropion, that gives the bibliography of Nariman Mehta, the inventor of Bupropion. I made a clumsy effort trying to insert a link to his
website earlier. I am now attempting to follow the guidelines that have been presented to me. A corrected article is located at user:beach4444/sandbox or the
 website, [].
Beach4444 (talk) 04:56, 3 September 2009 (UTC)
thread_title:  REQUEST for review of Bibliography of inventor of Bupropion 

message: Nothing is said about OCD in this article, but these findings seem to be of importance. 78.48.108.115 (talk) 14:09, 26 October 2009 (UTC)
replies: text: What is important about it? An open-label trial on 12 patients showed that bupropion is not effective for OCD... Big deal... The Sceptical Chymist (talk) 10:01, 27 October 2009 (UTC)
thread_title:  OCD 

message: (1)    It acts as a strong norepinephrine and weak dopamine reuptake inhibitor
(2)    It is about twice as potent an inhibitor of dopamine reuptake than of norepinephrine reuptake
both can not be true  —Preceding unsigned comment added by 78.42.4.217 (talk) 16:07, 10 January 2010 (UTC)
thread_title:  what is right? 

message: The percentages are relatively low for this drug, but it should be touched upon.71.134.42.129 (talk) 18:45, 3 March 2010 (UTC)
thread_title:  Discontinuation syndrome 

message: I'm surprised that nobody has yet discovered that Bupropion is indeed a strong aphrodisiac.  It certainly was for me.  The Salon article from 2000 was written a long time ago, but now that Bupropion has been marketed for smoking cessation under the name Zyban, surely many healthy men without depression or sexual dysfunction have had plenty of experience with it and discovered, as I did, a tremendous boost in libido, as well as increased sensitivity in the genitals and stronger erections.  My interest in sex was probably lower than most men's, but on Zyban, I soon started masturbating frequently and without experiencing "refractory" periods after orgasms.  My penis actually grew and developed an area of hypersensitivity and turgor on the right side, which caused it to bend towards the left.  That area became engorged, red, and sensitive when I got an erection, as if it were inflamed, that is, as if it were affected by inflammation.  I noticed that my penis was larger even without an erection.  Now that I've been off it for a long time, everything has gone back to the way it was before, except that (1) I'm a decade older and (2) I've lost my libido completely.  That brings me to another subject, the terminology of "dysfunction", "anhedonia", "sexual problem", etc.  Implied in all these discussions is the notion that people who aren't interested in sex at all have problems, and those who are driven to sexual activity are well.  That's absurd.  It's those with strong sex drives who have problems, and (at least among unmarried people) those who aren't the least bit interested in sex who have no sex problems.  The idea that life is unpleasant without sex is simply baseless, and should be rejected as nonsense. Unfree (talk) 03:09, 5 March 2010 (UTC)
thread_title:  Sex 

message: In the opening paragraph of this article, it states "Bupropion (Wellbutrin, Zyban), previously known as amfebutamone,[1]  is an atypical antidepressant and smoking cessation aid. It is also used to treat anxiety."
I'm pretty sure it is -not- used to treat anxiety, in fact I believe it exacerbates any pre-existing anxiety. Not only do I know this from personal experience taking the drug for 2 years now, but its mechanism of action involving norepinephrine, like other amphetamine-like drugs, can cause increased anxiety and is a hallmark side effect of stimulant medications. Bupropion is used to treat major depressive disorder but I've never seen it advertised to treat anxiety as well. There's no source corroborating this claim either so I think it should be removed unless I am wrong here. In the meantime, I added the fact tag to the initial claim, and when I looked further through the article it seems like somebody else fact-tagged another claim about its supposed usage in treating anxiety. -Novaprospekt (talk) 23:39, 29 May 2010 (UTC)
replies: text: unfortunately, most psychiatrists have no clue about psychopharmacology, and indeed do prescribe it, usually causing more anxiety problems, which is either ignored by the doctors as "beginning side effects that soon will fade away" or "counter-acting" by increasing the dosage, doing even more harm. --Diogenes2000 (talk) 08:47, 13 August 2013 (UTC)
replies: text: This may just be an anecdotal thing, but I am currently taking Wellbutrin for my anxiety, and it has helped very much. I have heard from my doctor, along with several pharmacists about its efficacy. Ducksandwich (talk) 20:49, 26 November 2013 (UTC)
thread_title:  Used to treat anxiety?? 

message: I have added Bupropion molecule structure image as I think it clarifies the structure of this chemical element, 
but now the page is too heavy..or may be it's OK? (3DRivers (talk) 10:50, 10 June 2010 (UTC)
thread_title:  Adding Bupropion molecule structure image 

message: Seems the half life is listed as three different numbers in three different parts of this article. Creates some confusion... and casts doubt on the validity of this page since they are presented as "facts" in each case - not mentioning that there must be some controversy over the subject...  —Preceding unsigned comment added by SundayDrinker (talk • contribs) 16:41, 25 November 2010 (UTC)
thread_title:  Half-Life 

message: Hi I'm new to all this and am a bit computer illiterate. I saw a case report which has some interesting points about bupropion in over dose: 
Clin Toxicol (Phila). 2010 May;48(4):385-7.
Bupropion toxicokinetic: a case report.
Donnelly K, Walkowiak HB, Donnelly C, Jenkinson E, Rizkalla J, Langford N.
Abstract
CONTEXT: The toxicokinetics of sustained-release bupropion are not well described.
CASE: A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed T(max) was found to be 8.25 h, the calculated alpha half-life 10.9 h (+/-SE of 4.47%), and the calculated beta half-life 19.8 h (+/-SE 12.62%). The alpha half-life and T(max) differ significantly from those seen in therapeutic doses.
DISCUSSION: Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.''
Interesting that overdose changes the kinetics. Could this go in either the overdose or kinetics section?
http://www.ncbi.nlm.nih.gov/pubmed/20230334
Cheers 194.176.105.41 (talk) 21:10, 14 January 2011 (UTC)
thread_title:  Bupropion Toxicokinetics 

message: Dear co-Wikis,
The chem infobox is really great and actually has become a tool I use regularly.
Thanks a lot for setting it up!
It would be great though if references where supplied alongside the values reported.
When the data is inserted it should only cost a couple more seconds, later it's not
easy at all...
Dont know how that would work technically though as they seem to be a different 'thing' than
the rest of the page.
I was trying to reach where the protein binding information was stored, but couldnt find it.
If a database is used (DrugBank, Chembl or ?) it would be great to have that specified.
Thanks again and hope a nice/practical solution can be found.
./Claus 
Posted: 213.243.199.58 (talk) 11:10, 12 July 2011 (UTC)
thread_title:  Chem infobox references 

message: The hyperlink to the article on the FDA web site that is reference number 160 needs to be corrected.  The one on there now doesn't work.  The correct link is: http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm153270.htm  
The name of the article for reference 160 is: Review of Therapeutic Equivalence Generic Bupropion XL 300 mg and Wellbutrin XL 300 mg
If someone could make that change who is familiar with editing these pages, I'd appreciate it!
Thanks.
Srpattee (talk) 03:42, 5 January 2012 (UTC)
replies: text: Fixed, thanks. Materialscientist (talk) 04:46, 5 January 2012 (UTC)
thread_title:  update link to reference number 160 

message: In the "Mechanism of Action" section, the article states that "Chronic treatment with bupropion led to a decrease in locomotor activity. [135]". However, reference [135] (the abstract of an article) doesn't suggest that chronic bupropion treatment reduces locomotor activity, but rather that chronic treatment increases locomotor activity, albeit to a lesser extent than acute treatment. If one looks at the full text, it becomes even more clear that this is what the authors meant. 
While an interesting tidbit, it doesn't actually tell us anything about bupropion's mechanism of action, so I'm thinking that the best course of action would be to just remove the sentence. Nargle25787 (talk) 22:46, 11 May 2012 (UTC)
replies: text: Go for it. Looie496 (talk) 22:48, 11 May 2012 (UTC)
thread_title:  Bad Interpretation of Study 

message: I read in this article that Wellbutrin is "non-abusable".  This is not true-as a drug counsellor I know firsthand that addicts are able to inject these pills-once dissolved in water-producing feelings reported to be similar to that of cocaine use.
Thought I should let you know...  — Preceding unsigned comment added by 76.67.120.64 (talk) 16:17, 20 June 2012 (UTC)
replies: text: As usual, provide reliable sources to back this up and it can be changed.  Also being in a position to know first-hand, I have never heard of bupropion being abused (though I have heard a couple horror stories from people who have attempted to abuse it)...  Addicts can and do inject a lot of crazy stuff, which I'm sure you know; just because an addict reports getting high off it, does not mean that they actually are...  the subjective experience of hardcore polydrug addicts can be a unique thing. 156.98.129.16 (talk) 16:26, 10 July 2012 (UTC)
thread_title:  abuse 

message: This article has a few problems. I see some [citation needed] tags, and an [improper synthesis] tag under "Psychiatric". I find it very strange that this one sentence has ten footnotes, which is certainly  eyebrow raising. Some sections are also short and choppy, including Psychiatric, Interactions, while other sections are underdeveloped (Detection in Biological Fluids, Synthesis, Animal research). Ten Pound Hammer • (What did I screw up now?) 07:26, 22 May 2013 (UTC)
replies: text: There also seems to be a fair bit of primary research within the article so yes I to would support it going to FAR. Doc James (talk · contribs · email) (if I write on your page reply on mine) 09:53, 22 May 2013 (UTC)
replies: text: I just spent a few hours doing quite a massive rewrite -- the article is now half as long and has half as many sources.  Most of the primary sources are now gone.  I like to work from the bottom up when cleaning an article -- the lead and the top two sections are the only ones I haven't yet addressed.  I haven't done anything to check the validity of most of the statements that were already attributed to good secondary sources.  I don't have much experience working with drug articles and certainly don't have any expertise regarding this drug (I still can barely pronounce the name), so anybody who sees a need for changes should step in.  (Boghog has already reformatted a bunch of refs.) Looie496 (talk) 03:59, 28 May 2013 (UTC)
replies: text: Followup:  I've now rewritten the lead and the first two sections, so the slash-and-burn part of fixing the article is basically completed.  There are still a few smaller issues that need addressing, but comments related to what the article needs to survive an FA review would be welcome. Looie496 (talk) 17:13, 28 May 2013 (UTC)
thread_title:  Problems 

message: http://globalnews.ca/news/846576/antidepressant-wellbutrin-becomes-poor-mans-cocaine-on-toronto-streets/ people are risking death or serious disfiguration due to the fillers in this medicine.65.93.33.119 (talk) 19:13, 18 September 2013 (UTC)
thread_title:  Cooking and shooting Wellbutrin 

message: An IP editor just added alopecia to the list of side effects in this edit 
I note that there is a long list of references for the side effects, but ideally this needs to be inline citation. See for example Xerostomia#Signs_and_symptoms, where each item in the list is directly sourced. A bit annoying, but only needs to be done once. Future editors are less likely to add unreferenced content, and unreferenced content that is added is more easily identified. Thank you, Lesion (talk) 10:05, 30 October 2013 (UTC)
replies: text: That whole long list of side effects was just added recently, and I personally don't think it belongs, at least beyond the common ones.  In any case I've removed alopecia pending a source for the information. Looie496 (talk) 14:52, 30 October 2013 (UTC)
thread_title: Adverse effects

message: At the moment there is no references to support material in the lead. Fuse809 (talk) 11:22, 9 November 2013 (UTC)
replies: text: Many articles follow the practice of minimizing references in the lead and placing the necessary references in the body of the article, for the sake of readability.  Regarding the changes you made, it is important to realize that this is a very widely read article, with over 1000 page views per day, and surely the great majority of readers are non-scientists who want to get basic information about the properties of the drug that are relevant to somebody who uses it.  It's important that at least the lead give them the information they need, in language as non-technical as possible.  I feel like at least the main factors that distinguish Bupropion from SSRIs belong in the lead. Looie496 (talk) 15:50, 9 November 2013 (UTC)
thread_title: Lead

message: This page violates Wikipedia accesibility standards. See: Wikipedia:Manual_of_Style_(accessibility)#Animations.2C_videos_and_audio   "To be accessible, an animation (GIF – Graphics Interchange Format) should either: not exceed a duration of five seconds (which results in making it a purely decorative element),[6] or be equipped with control functions (stop, pause, play).[7]"  I find that rotating graphic extremely distracting and I know other users do as well. MadScientistX11 (talk) 19:50, 23 December 2013 (UTC)
replies: text: This gif is 3 seconds long, so it doesn't need to be equipped with control functions. The policy doesn't address animations being subjectively distracting. You say that it distracts others... Let them come speak for themselves, then. I, for one, see nothing wrong or distracting with this gif. Attaboy (talk) 01:58, 25 December 2013 (UTC)
replies: text: I don't know what you mean about 3 seconds, it goes on indefinitely on my computer, it doesn't stop animating after 3 seconds or ever as long as I waited. And saying "well I like it anyway" is not a justification for ignoring a standard design policy. When I said "it anoys others" I mean I have talked to other people who find these kinds of animations very unsettling.  I shouldn't need to take a poll, the fact that it clearly violates Wiki accesibility guidelines should be enough. MadScientistX11 (talk) 13:54, 25 December 2013 (UTC)
replies: text: I agree that the animation is distracting and would favor removing it. Looie496 (talk) 16:46, 25 December 2013 (UTC)
replies: text: Go take a look at the file. The gif is 3 seconds long. It does what all gifts do: repeat itself. There's nothing wrong with this. Attaboy (talk) 14:58, 26 December 2013 (UTC)
replies: text: It doesn't matter what it says in the file what matters is what the user sees. I just used the timer on my phone and the gif (for THIS article) kept animating for over a minute. (BTW it didn't stop after that, I don't think it ever stops) If you see something different then that is a technical issue although so far you haven't actually said what you see on the screen you only have said what the file says. So look at the article. Does the image stop animating and when? And if not look at that quote I have up above from the Wikipedia accesibility standards and tell me how that behavior doesn't clearly violate the standard. MadScientistX11 (talk) 15:52, 26 December 2013 (UTC)
replies: text: I see. I don't have the know how to change it the file so it won't repeat. If you can find an alternate image, you can go ahead and change it out. Attaboy (talk) 17:50, 26 December 2013 (UTC)
replies: text: Unfortunately, I don't have the skills to edit it either. I don't think its that easy to do, I can usually figure these things out most of the time and I tried to deal with this issue for another gif and it seemed like the only way to deal with it was to turn it into a video which I have neither the skill nor interest in doing.  I don't know enough about this topic to feel competent making decisions about alternative images, whether to just remove the image, etc. So I'm just whining about the problem but at least the issue is documented. MadScientistX11 (talk) 20:51, 26 December 2013 (UTC)
replies: text: I appreciate these GIF images as they give a great 3D view of the molecular structure. Disabling animation would make them less demonstrative. However I have to admit that they are a bit distracting and also a bit dizzying. Therefore I suggest to slow them down. By the way: Using Firefox, animations can be either turned completely off or prevented from repeating over and over. Enter about:config in the address bar, hit Enter, search for image.animation_mode and change the preference either to none or once. Hope that helps. Cheers. SelfishSeahorse (talk) 10:59, 27 December 2013 (UTC)
replies: text: How distracting this is is a matter of opinion and we will never agree. I find it terribly distracting and the rate of movement has nothing to do with it but I appreciate that other people have different opinions. That is why we have standards. The discussion here shouldn't be on how fast the gif is moving or how much value a moving animation has over a non moving one the starting point should be: WHY DOES THIS PAGE VIOLATE WIKIPEDIA ACCESIBILITY STANDARDS? Is there some really pressing reason that we need an animated picture of the molecule? I haven't heard one and IMO without such a justification the only thing we should be talking about is how to change the page so it DOES NOT VIOLATE WIKIPEDIA ACCESIBILITY STANDARDS. MadScientistX11 (talk) 15:20, 27 December 2013 (UTC)
replies: text: I've created a new version of the file. The animation now stops after one cycle and is half the speed. Hope everyone is lucky now. :) SelfishSeahorse (talk) 21:08, 27 December 2013 (UTC)
replies: text: Great! thanks. MadScientistX11 (talk) 13:54, 28 December 2013 (UTC)
thread_title:  Rotating graphic is TERRIBLE web design 

message: Wellbutrin and psychic energy?  Help me understand.. Freudian1 (talk) 19:44, 26 October 2020 (UTC)
thread_title:  Wellbutrin