Talk:Orexin

message: This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)
thread_title:  WikiProject class rating

message: Could someone do a text search in the article for "nympholepsy" and check if the usage is appropriate? or was it intended to be "narcolepsy"? According to a online dictionary, "nymplolepsy" means "an emotional frenzy" 137.92.97.114 (talk) 03:10, 30 December 2007 (UTC)
replies: text: I'm pretty sure that the editor meant narcolepsy. I'll make the change. -- Derek Ross | Talk 03:27, 30 December 2007 (UTC)
thread_title:  Nympholepsy? 

message: Can anyone clarify/confirm/deny the hypocretin effect on thyroid hormones suggested by www.naturalnews.com/025325.html  ? 
"... hypocretins are wired to many different aspects of nerve function. They provide input to the primary department in the hypothalamus gland that controls the production of TRH (thyroid releasing hormone), which has control of the pituitary (which makes TSH), and thus has overall control of thyroid hormone production. The message hypocretins deliver is as follows, "We are in a state of high stress alert wherein our brain must remain hyper-vigilant, however, to conserve fuel so we don't perish, turn down the production of thyroid hormone in the rest of the body (a self preservation strategy, especially during times of famine or infection)."" 
Some data at "Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men " 
but I'm not sure if it's too specific to a disease state.   Rod57 (talk) 11:23, 16 January 2009 (UTC)
replies: text: I looked at either TRH or TSH (can't remember which now) in a few rats after chronic orexin-A administration into the lateral hypothalamus, and I found no effect on whichever of those two I tested. It was in the late 1990s, so my memory is foggy. We didn't pursue it any further. Dcs002 (talk) 07:19, 21 September 2009 (UTC)
thread_title:  Effect on thyroid hormones 

message: I just added discovery of receptors, clarified authorship of Sakurai and colleagues, referenced clone 35 in the 3rd paragraph, and removed "dispute" from 4th paragraph.
Ever since the infancy of this article, the name Masashi Yanagisawa has been featured prominently, and I've wondered if he or someone in his lab had been editing this page to hail him as the sole discoverer of the orexins. The convention is usually that the first author of the paper is the first name credited with the contents of the paper. Many years ago I switched the reference from Masashi Yanagisawa (no "et al" or "and colleagues" at the time, just him) to Sakurai and colleagues, and I added the reference to de Lecea and colleagues, but within a few days my changes were erased and Yanagisawa was again hailed as the sole discoverer. And it's not just his name, it's Masashi Yanagisawa at the University of Texas Southwestern Medical Center at Dallas. No one else's affiliations are named in this article, and I'm not sure how appropriate it is. And until I inserted the reference to Gautvik and clone 35, Yanagisawa's name was always the one that appeared first, though that group's paper was actually the third to be published on these peptides.
I've always thought that Gautvik and colleagues and de Lecea and colleagues (same group really) should get the lion's share for the discovery of these peptides because a) they first identified clone 35, b) their work published in 1998 was a continuation of their earlier published work, which I think establishes them as the pioneering lab group, and c) well, their paper was published before Sakurai and colleagues, albeit only a month (which is really considered to be the same time). Sakurai and colleagues deserve a great deal of credit for the thoroughness of their description of the peptides, getting the exact sequence correct, describing one function (feeding) of these peptides, and most of all for discovering the receptors. (Maybe I'm also driven by what I perceive as the promotional nature this article has historically had in regards to Yanagisawa.)
The reason I removed the word "disputed" from the fourth paragraph is that I believe it connotes a sense of animosity that doesn't exist. Researchers simply publish under whichever name they prefer, being sure to mention the other name, and everyone seems to be waiting too see whether the field decides on one name or the other. That's the attitude I've seen at conferences anyway. Yes there are reasons given on both sides why the name should be one or the others, but these are more like competing proposals than a subject of real dispute. Dcs002 (talk) 07:01, 24 September 2009 (UTC)
replies: text: As you of course know, the last author is frequently the person who designed and managed the work, but I completely agree that the usual way of citing the work would be either "Sakurai et al" or "the laboratory of Masashi Yanagisawa"; just plain "Masashi Yanagisawa" is misleading.  Anyway, it looks like the reference dates back to the very first version of the article in 2003, and probably was based on a press release, since the editor who created the article doesn't seem to focus much on biology of any sort.  Regards, (and remember to sign your talk page messages!) Looie496 (talk) 00:17, 24 September 2009 (UTC)
thread_title: History and nomenclature

message: Why is there a link to CIMIT in this section? Is it here for a purpose other than garnering publicity for the organization? I think it should be removed. Dcs002 (talk) 09:47, 9 October 2009 (UTC)
thread_title: External links

message: The orexin article says:
"Hence obesity in narcoleptic patients may be due to orexin deficiency leading to brown-fat hypo activity and reduced energy expenditure."
This is, however, impossible because adult humans do not have brown fat.  — Preceding unsigned comment added by 141.20.48.39 (talk) 10:01, 5 June 2012 (UTC)
replies: text: That's not actually true. Adult humans have less brown fat than children but they still have some, mostly in their upper chest and neck. See our article on Brown fat for pictures. -- Derek Ross | Talk 22:13, 6 June 2012 (UTC)
thread_title:  Brown fat activation 

message: Narcolepsy is mentioned several times before it is defined under “wakefulness.” I would suggest to either define it (or describe it) earlier in the article or just hyperlink it for people to read about it themselves.
I also think the last paragraph under “wakefulness” can be categorized under a different heading. It does not directly relate to wakefulness, but is useful because it is talking about the problems that can occur if one does not have orexin-producing neurons.
Under ‘food intake,’ why does orexin increase the craving for food? You could tie this in with the increased obesity rate for those with low levels of orexin.
The ‘energy metabolism’ section could be expanded or even grouped with the ‘food intake’ section.
Overall, the article was very informative and had a lot of good content! Cbruha11 (talk) 15:19, 28 March 2014 (UTC)
replies: text: Well, just a guess but narcoleptics are possibly more prone to depression owing to the difficulty of moving forward with their lives caused by sleeping and cataplexy. It may well be that orexin makes them less depressed than they would otherwise be and yet does not have enough of an effect to cancel out the negative feelings caused by that frustration. -- Derek Ross | Talk 07:49, 11 November 2015 (UTC)
thread_title:  Structure & Content Suggestions 

message: It's been a while since I visited this page, but I just noticed this: "Studies suggest that orexin-A may be of greater biological importance than orexin-B." I know I've been away from orexin research for a long time now, but on its face this statement seems preposterous. First, the fact that orexin-B has been observed as less potent or less effective than orexin-A at anything only means we don't know if its main endogenous function is to do something we haven't thought to test. Orexin-A is clearly more effective at inducing feeding. Does that make it more biologically important? We don't know what we don't know here. We don't know all of the possible functions of these peptides. Second, when I was studying the orexins (which ended in 2006), orexin-A had simply been studied more than orexin-B. We knew more about it, so researchers had a lot more to build on, and therefore a lot more was published, building a clearer picture of its function in the brain. It was more effective at inducing the effects that we were looking for, but we have no idea what all of its effects are. We can't know that for any neuropeptide until we figure out exactly how the human brain works. Third, importance is a vague and dependent statement of a thing's value, and is nearly a meaningless thing to say on a scientific level. Scientists speak in specifics. Important for what? Appetite? Arousal? Memory? Important how? Activation? suppression? Survival under extreme conditions? The fact that orexin-B is preserved across so many species is compelling evidence of its evolutionary importance. We either need to source that claim or get rid of it. Dcs002 (talk) 11:07, 24 May 2014 (UTC)
thread_title:  Orexin A of greater importance? 

message: We should probably add the epidemic (1,300 cases) of narcolepsy in Europe caused by the Pandemrix influenza vaccine, which triggered an autoimmune reaction to hypocretin receptor 2. An exposed region of the influenza nucleoprotein A shared residues with a fragment of the first extracellular domain of hypocretin receptor 2. People with HLA-DQB1*0602 haplotype developed protective immunity to influenza and an autoimmune reaction to hypocretin receptor 2, leading to death of the cells and incurable narcolepsy. There were 1,300 cases out of 30 million doses of Pandemrix, so it's a relatively rare reaction, on the order of the other known, rare risks of influenza vaccines. 
Ahmed SS,Volkmuth W, Duca J, et al. 
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 
http://stm.sciencemag.org/content/7/294/294ra105
Science Translational Medicine. 01 Jul 2015; 7(294):294ra105. DOI: 10.1126/scitranslmed.aab2354
Gretchen Vogel
Why a pandemic flu shot caused narcolepsy
http://news.sciencemag.org/health/2015/07/why-pandemic-flu-shot-caused-narcolepsy
Science. 1 July 2015 DOI: 10.1126/science.aac8792.
And Science calls it hypocretin. Is that the name now? --Nbauman (talk) 03:15, 6 July 2015 (UTC)
replies: text: Both names are still widely used in the literature -- orexin a bit more widely, I think.  Regarding the vaccine, it might be reasonable to add a paragraph on that story. Looie496 (talk) 15:39, 7 September 2015 (UTC)
thread_title:  Influenza vaccine 

message: I'm not a specialist in this area, but it does appear that the clause, "but immunocytochemistry tactics revealed the various projections this area truly had to other parts of the brain. " from the second paragraph of the Discovery section needs some kind of verb.
..had to connect...???
I'm hoping that someone can add the right verb.  — Preceding unsigned comment added by Joel1947 (talk • contribs) 17:11, 29 July 2017 (UTC)
thread_title:  Housekeeping 

message: High plasma triglycerides (from a high fat diet) and low blood sugar (hypoglycemia) increases orexin levels, which increases appetite through orexin-stimulated neuropeptide Y action. A high fat diet more than a high calorie diet has been shown to increase obesity and orexin release.
:The poorly sourced content needs to be re-added with a review.  Not primary sources.  Please with WP:Primary and WP:3RR. Petergstrom (talk) 17:59, 3 February 2018 (UTC)
replies: text: Thanks Boghog - is it ever the case that a 'citation needed' or 'better source needed' tag can be added.--Iztwoz (talk) 18:37, 3 February 2018 (UTC)
replies: text:  The above primary sources are both animal studies and the accompanying text implies that results of these studies may also apply to humans.  This is not acceptable per WP:MEDANIMAL. One would need to modify the text to state that these are animal studies. Boghog (talk) 19:31, 3 February 2018 (UTC)
thread_title:  Edit War 

message: — Assignment last updated by Achait2023 (talk) 17:11, 5 December 2023 (UTC)
thread_title: Wiki Education assignment: Adv Molecular Bio Bass-FSU-Fa23