Talk:Oxymorphone

message: if its 6-8x as potent as morphine that means its 3-4x as potent as heroin.  on wiki's heroin & morphine pages it says "extremely high" for dependence liability yet for oxymorphone which is 3-4x and 6-8x as potent, and yet it says only "high" dependence liability.  heroin is legal in most european countries for medical use, and i dont understand how more potent opioids can be said to be less addictive, fentanyl, oxymorphone and hydromorphone are all legal for prescriptions and are all at least 2x if not MUCH more potent than heroin.  are the dependence liability ratings on the wikipedia pages from the FDA or what source?
even in the illict use section of this Oxymorphone wiki page it says: "Until its removal from the United States market in the early 1970s, oxymorphone in the form of Numorphan 10 mg instant-release tablets was one of the most sought-after and well-regarded opioids of the IV drug using community. Known popularly as "blues" for their light blue color, the tablets contained very few insoluble binders — making them easy to inject — and were extremely potent when used intravenously. "Blues" were also considered to be especially euphoric; comparable to or better than heroin"
dependence liability should be extremely high for both or for at least oxymorphone if heroin & morphine are going to have that.
*Not quite - the current version is time-release only, making it virtually impossible to convert to an injectable for drug users. The low efficiency of orally administered opiods (hence, higher cost), further decreased through time-release, makes this drug much less euphoric and desirable for addicts. If anything, the time-release formula makes it more suited for substitution treatment.  —Preceding unsigned comment added by 128.195.186.78 (talk) 11:21, 27 September 2007 (UTC)
replies: text:  I added a CITATIONS NEEDED tag to the end of the line, "It differs from morphine in its effects in that it generates less euphoria, sedation, itching and other histamine effects".  I might remove it eventually because this seems pretty anecdotal. --SlimNm (talk) 01:20, 23 December 2010 (UTC)
thread_title: dependence liability

message: note:the image of oxymorphone is a not right, the single bonded o's hould be OH's, as in dihydroxy. (comment moved from page by Dirk Beetstra T C 08:53, 13 November 2006 (UTC)
thread_title: Image

message: Where did this chemistry info about propenyl and cinnamyl esters come from? I've studied opioids extensively and have never heard of this. I would be hard pressed to find research to back it up. I would think if those groups were known to be potent, there would be research. Furthermore, acetic acid can form an ester with the hydroxy groups, but since cinnamyl and propenyl groups are not carboxylic acids, they cannot form an ester bond. If one were to condense cinnamyl and propenyl alcohols with the 6 and 14 hydroxys, you would have a propenyl ether and cinnamyl ether.-Junky getting a PhD—Preceding unsigned comment added by 144.92.229.97 (talk • contribs) 
:I'm not sure who added the info about the SAR but it's accurate. I have a couple of journal articles about the development and testing of the compounds mentioned in the article and would post them as citations if I could find them but they are currently unavailable due to computer trouble. I will post them as soon as I can find them, unless someone beats me to it. Also, it would be nice to know what's being measured when the article says such and such a derivative is "(x) times more potent than" the parent compound (or morphine? the article's not clear about that either), how exactly it's more potent. As an analgesic? In the rat tail-flick test? The formalin test? In vitro Ki values for opioid receptors? MOR, KOR, DOR, ORL-1? Et cetera.
The figures come from here:
Greiner E, Spetea M, Krassnig R, Schu¨ llner F, Aceto M, Harris LS, Traynor JR, Woods JH,
Coop A, Schmidhammer H (2003) Synthesis and biological evaluation of 14-alkoxymorphi-
nans. 18. N-Substituted 14-phenylpropoxymorphinan-6-ones with unanticipated agonist
properties: extending the scope of common structure-activity relationships. J Med Chem
46:1758–1763  —Preceding unsigned comment added by 90.203.62.197 (talk) 18:32, 17 December 2010 (UTC)
replies: text: As for the 14- derivatives of oxymorphone, I'm pretty sure they are ethers and not esters. Again, I would have to check the referenced (though not cited) articles in order to be certain. Another modification that increases potency that isn't mentioned is the substitution of a phenethyl group for the N-methyl group. As far as I know, no one has synthesized and tested N-phenethyl-3-acetyl-14-cinnamoyloxymorphone yet, so its effects are idle speculation at this point. Porkchopmcmoose 02:40, 31 December 2006 (UTC)
thread_title: Origin of propenyl and cinnamyl ester info

message: :On the other hand oxymorphone can generate a serious narcotic habit rather quickly in those who take it recreationally in that it has powerful euphorigenic (contradiction to first paragraph which says it has less euphorigenic properties than morphine.)properties which some rank as the highest amongst narcotics, many placing it above morphine, heroin, hydromorphone, and dextromoramide.
somebody seems to have edited this and noted that the opening paragraph is inconsistent with this further down in the abuse section. which is it? i've never abused it, so i couldn't comment. :) 76.111.68.88 (talk) 02:48, 24 June 2010 (UTC)
replies: text: So I fixed this and a bunch of other stuff. I'm a long term opiate patient (not a junky) and have been prescribed just about everything under the sun. Right now, I'm taking Opana, so I figured I'd expand that section a little, and clean up the wording I mentioned above. And yeah, it was a slobbery mess. 76.111.68.88 (talk) 10:43, 21 July 2010 (UTC)
thread_title:  so which is it re: euphoria? 

message: In the article, under the illicit use section, it has a kind of slant that it has empathogenic, anti-depressive properties. It seems like the article is glorifying the drug. Now, I for one agree with these things, and do think opioids have these types of uses and should be talked about more. However, it kind of seems ridiculous that the main place for all this info is some random opioid. It seems that they removed that part from the oxycodone article -- I think we should either remove it from here, move it to the opioids article, or put it back in the oxycodone article. For consistency, y'know? 69.142.35.12 (talk) 09:23, 23 May 2011 (UTC)
replies: text: Pain research has shown that chronic pain tends to lead to clinical depression. Alleviate the pain, the depression subsides. That doesn't make an opioid analgesic an anti-depressant, only a treatment for the cause of the clinical depression.Wzrd1 (talk) 02:52, 27 October 2012 (UTC)
thread_title:  "empathogen" 

message: http://www.bluelight.ru/vb/attachment.php?attachmentid=4825&d=1188845386 Nagelfar (talk) 23:32, 3 March 2012 (UTC)
thread_title:  Oxymorphone tautomers 

message: Uncertain if including the information would improve the article. It appears that some of the compounds in the newest formulation may be involved. Uncertain at present if the polyethylene oxide (PEO), polyvinyl alcohol, and talc formulated in to prevent pulverizing the tablet is responsible or not. The URL to the health alert network article is: http://emergency.cdc.gov/HAN/han00331.asp Wzrd1 (talk) 02:56, 27 October 2012 (UTC)
thread_title:  New CDC alert on recreational use and thrombotic thrombocytopenic purpura 

message: Adding information on the HIV outbreak in Indiana due to the injection use of Opana. Tarynng5 (talk) 04:33, 17 October 2018 (UTC)
thread_title:  Opana abuse leads to HIV outbreak 

message: Update the list of side effects to include common side effects of taking the medication. This will also include common DDIs (drug-drug interactions) and Drug-Disease interactions/considerations.
Update "the medical use" section that would go over treatment algorithms and guidelines of the use of this drug. For instance, would it be used 1st line, 2nd line, last line, etc, and in under what particular circumstances would a prescriber start a patient on this opiod medication. Will clean the section into a more reader friendly, and organized format. (Sae Lome lee)  — Preceding unsigned comment added by Saellee (talk • contribs) 04:54, 17 October 2018 (UTC)
thread_title:  UCSF SoP CP 133 Proposed Edits 

message: ====Edit October 17 2018====
Update common dosing forms and amounts, as well as recommended dosages for patient use with their indications based on medical guidelines. The way it currently is on the WikiPage under society and culture only goes into the brand names. I want to maybe make a table, delving more into an easy way to look at the brand name offered (or generic) and know what dosage form the medication comes in, followed by regular dosing practices. MichelleBretschneider (talk) 04:43, 17 October 2018 (UTC)
thread_title: UCSF Student Updates/Edits Log

message: Update common dosing forms and amounts, as well as recommended dosages for patient use with their indications based on medical guidelines. The way it currently is on the WikiPage under society and culture only goes into the brand names. I want to maybe make a table, delving more into an easy way to look at the brand name offered (or generic) and know what dosage form the medication comes in, followed by regular dosing practices. MichelleBretschneider (talk) 04:43, 17 October 2018 (UTC)
thread_title: Edit October 17 2018

message: Added the "Availability" heading with "Brands and Forms" and "Oxymorphone Dosing" subheaddings. Decided not to go into depth on dosages for use as that is more patient and doctor specific. The information I was going to add to "Society and Culture" I instead just added here.
Also added "Indications" table under "Medical Uses" heading for easier/faster information gathering. MichelleBretschneider (talk) 02:51, 2 November 2018 (UTC)
thread_title: Edit Nov 1, 2018

message: Made edits based on feedback from peers. Was unable to link "IR" and "ER" to a page that would describe them, since no such pages on Wikipedia exist. Instead added a sentence on what they mean and how to find out more information on this information at the bottom of the 'Brands and Forms' section. Added links to other wikipedia articles for key words used in 'Brands and Forms.' Updated the sources to remove any lexicomp sources, specifically for the dosing table. Removed table stating indications under 'Medical Uses' as I was unable to find proper citation (readily available outside of lexicomp/closed publication guidelines) for most of the indications stated in the table initially, and removing those un-citable indications left only 2 indications, which were appropriately stated in the paragraph above and served no purpose being re-stated in a table. Removed the sentence in 'oral dosage forms' that duplicated a statement made twice already in the page about the removal of Opana ER from the market in order to prevent redundancy. MichelleBretschneider (talk) 05:30, 20 November 2018 (UTC)
thread_title: Edit Nov 19, 2018

message: Peer Review by Group 14: 
1. Does the draft submission reflect a neutral point of view? If not specify
In my opinion, the draft submission does reflect a neutral point of view. Facts were used and backed up with citations from guidelines on pain management. It showed the benefits and risks of using oxymorphone, which is consistent with the neutral content. 
2. Are the points included verifiable with cited secondary sources that are freely available? If not specify
So far - cited secondary sources are freely available. Oral dosage forms were accessed via Lexi-Comp and may not be freely available to the public. Can consider referencing package insert. Henryhuang24 (talk) 04:22, 8 November 2018 (UTC)
thread_title:  Pharmacy Student Peer Reviews