Talk:Olney's lesions

message: I think this is a significant improvement in the page. I feel that we've created a concise and objective resource about Olney's Lesions. Thanks, Valoem!
np anytime =D Valoem talk 03:04, 15 September 2006 (UTC)
thread_title: Major Improvement

message: Your substitution of "serotonergic" for "psychedelic" isn't correct. For one, according to Psychoactive drug, THC is a psychedelic, and it does NOT act on the Serotonin systems. Secondly, I'm having a debate with Thoric, the creator of the diagram on that page, on Thoric's talk page about whether that the term "psychedelic" includes dissociatives like DXM and ketamine, the very drugs that DO cause Olney's lesions. Therefore, I'll change the title back. Otherwise, I like that edit.Jolb 03:25, 30 January 2007 (UTC)
thread_title:  Psychedelic 

message: Hey, I reverted your edit because that Carliss article is already referenced in the text:
:However, oral administration of dextromethorphan does not cause vacuolization in rats' brains.[5]
More importantly, that study was particularly about ORAL administration of DXM, (making it more relevant for humans since they usually take DXM orally) which you left out of your edit. Jolb 23:45, 26 October 2007 (UTC)
thread_title:  About the Carliss Article 

message: Olney himself is now dying of amyotrophic lateral sclerosis, so whatever he might have been doing in his personal life to avoid neuronal degeneration and death didn't work very well.  —Preceding unsigned comment added by 75.15.137.89 (talk) 17:36, 9 May 2008 (UTC)
replies: text: Whoops, wrong Dr Olney.  My mistake. 75.15.137.89 (talk) 17:39, 9 May 2008 (UTC)
thread_title:  Olney's life 

message: Maybe I just overlooked something, but while the article currently contains a nice amount of information on how and why Olney's lesions develop it seems that it doesn't really explain what effects (on behavior and otherwise) these lesions actually produced in the lab mice. If there are any such effects, other than the increased mortality, it would be nice if someone could include the information in the article. Thanks. --84.186.245.124 (talk) 22:36, 23 October 2008 (UTC)
thread_title:  Effects of the lesions 

message: Now I'm translating this article for the RuWiki. One note to check out: age-dependent change in the structure of NMDAR might underlie the increased mortality in the old rats (there's a "developmental change" in NR subunits composition). --CopperKettle (talk) 20:43, 3 December 2008 (UTC)
replies: text: Another one "William White, a DXM researcher". I have questions: Did he conduct any basic research? PubMed doesn't seem to find any links to the query "White W Dextromethorphan". Did he had any neuroscientific or biological degree? --CopperKettle (talk) 22:00, 3 December 2008 (UTC)
replies: text: How about exchanging the "researcher" title into the less misleading "amateur experimenter" or the "self-taught experimenter", "an experimenter without a degree in biology" etc.? I'll wait a couple of days for the answer and then I'll be bold and change it. --CopperKettle (talk) 12:38, 4 December 2008 (UTC)
replies: text: Here I've found a link to W.White's email, bwhite@oucsace.cs.ohiou.edu - in the .edu domain, a university, but dated back to 1996. Hmm.. --CopperKettle (talk) 12:56, 4 December 2008 (UTC)
replies: text: Maybe he was a student? I'd suggest calling W. White just a writer at this point.Shubi (talk) 17:52, 24 January 2009 (UTC)
replies: text: I would say that he did research because the FAQ itself was an original synthesis of information from peer-reviewed scientific literature and from information on the subjective effects of DXM that he received from numerous (hundreds, I believe) of users.   The last time I had any correspondence with Will White, about 5 years ago, he was continuing to pursue a PhD in neurobiology or some related field (all I know is that it had something to do with modelling neuronal systems with partial differential equations).  I don't think calling him a "DXM researcher" gives him undue credit, but it probably would not be how he described himself.  I think he should just be referred to as the author of the FAQ, because he certainly didn't have a career researching DXM, even though he did spend a lot of time researching DXM for the FAQ. AlkaloidMan (talk) 04:22, 24 October 2010 (UTC)
thread_title: As the translation goes on..

message: "These vacuoles lead to a concentration of microglia and Heat-Shock Protein 70 (Hsp70), which formed irreversible lesions. The dissociatives also seemed to form antecedents of other forms of brain damage in the test subjects."
The reference given at the end is for Olney et al. (1989).  I have a copy of the paper.  It's only 3 pages long.  It says absolutely NOTHING about Hsp70.  It says absolutely nothing about these neurotoxic changes or vacuolation being irreversible.  To the contrary, the paper makes it clear the the affected cells appear to return to normal after 24 to 48 hours.  Repeated doses with NMDA antagonists did not lead to a cumulative effect, leading the authors to hypothesize that cells became "tolerant" to the effect of repeated NMDA antagonist exposure.  To attribute the statement: "dissociatives also seemed to form antecedents to other forms of brain damage in the test subjects" to Olney et al. (1989) is inaccurate.  It's looks to me like I can be essentially certain that whoever cited Olney et al. (1989) for the last sentence (or the first whole paragraph) has not ever read the paper.  Please make sure that you actually read a paper before citing it as a source of information.  The stuff here is completely inaccurate.
Olney JW, Labruyere J, Price MT. (1989) Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs.  Science.  244: 1360 - 1362. AlkaloidMan (talk) 04:48, 24 October 2010 (UTC)
thread_title:  Please make sure to actually read papers before citing them 

message: This drug will put into a non-coherantstate with super human strenghth. Will cause great depression and suicidal thoughts.Highly addictive.  — Preceding unsigned comment added by 74.99.173.166 (talk) 04:22, 2 October 2012 (UTC)
replies: text: what drug... Precisely what I was fathoming. 2600:1006:B133:1B9E:0:1F:AE9:6801 (talk) 16:30, 6 June 2024 (UTC)
thread_title:  Zombie Effects 

message: I would like to remove the last sentence in the Controversy section for two reasons:
1. William E. White is a dubious person which cannot be related to any expert on the field
2. The statement is outdated, recent research shows evidence for Olney's lesions in humans. See my addition in the history section.
If no one objects for good reason I will remove the sentence "White therefore concluded that based on some fundamental differences between rat biology and human biology and because there have only been very few studies done on the occurrence of Olney's lesions, no connection can currently be proved or disproved" in a few days.
LuxMaryn (talk) 01:25, 28 February 2016 (UTC)
thread_title:  Remove White's opinion 

message: The intro section needs to be completely rewritten to cite actual sources, not provide someone's useless opinion.  — Preceding unsigned comment added by Orangesherbet0 (talk • contribs) 06:44, 5 November 2019 (UTC)
thread_title:  Intro section sites exactly one source and mostly just gives opinion-based non-cited information 

message: I can't find the article "NMDA receptor antagonist neurotoxicity and psychotomimetic activity" anywhere, and the contents seem kinda important for the article, as it's our only source that GABA modulators also get administered with NMDA antagonist anesthetics.  
* PubMed only has the abstract, and I'm not sure if the bibliographic data is right.  
* Google Scholar has 3 versions of the article, but they're all abstracting services like PubMed.  
* It took a little digging, but Wiley has an archive of Anesthesia, an English-language journal published monthly by the Japanese Association for Anesthesiology.  "Masui" [麻酔] is Japanese for Anesthesia, and Googling the original hiragana pulls up the JAA in a Japanese-language page that (via Google Translate) says it's an English-language journal published monthly, so I think this is it.  
* The article doesn't appear in issue 52 of that archive, and in fact there is no article published with that author list anywhere in the journal.  I haven't tried looking for all possible subsets of the authors, but the first author has only published two articles there, and none of the PI's 62 hits seem relevant.  
* The PI's name romanizes to Shingu Koh, and I tried Googling around for his homepage at Kansai Medical University to see if he posted a link to it.  But I'm neither sure if he has a homepage, nor that, if it exists, I could find it without the original katakana.  (I tried guessing with a romanization table, but no luck.)  
* Presumably the IP who added it had access to the article, but they haven't edited under that address since 2007, and it's hard to find an IP user anyways.  
Do you, dear reader, know where to find a copy? Bernanke's Crossbow (talk) 02:46, 19 June 2023 (UTC)
thread_title:  Does the "NMDA receptor antagonist neurotoxicity and psychotomimetic activity" exist?