Talk:Bupropion

message: Many of the refs are old. Some of the conclusions appear a little too positive. Needs updating and removal of primary sources. Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:04, 23 January 2014 (UTC)
replies: text: At least one named reference, "Dwoskin2014", is forwardly-defined, i.e. used as a refname before the reference has been defined.  While Wikipedia permits this, the potential result is that adding a new use of the refname disrupts the reference numbering, spawning unnecessary changes. D A Patriarche, BSc 08:36, 24 March 2017 (UTC)
thread_title: Article needs work

message: The section on contraindications needs to be corrected on the subject of alcohol and benzodiazepines. It is correct that conditions and drugs that lower the seizure threshold would be contraindications to taking buprioprion because buproprion also lowers the seizure threshold.
I would suggest an edit to the beginning of the contraindication section along the lines of:
"GlaxoSmithKline advises that bupropion should not be prescribed to individuals with epilepsy or other conditions that lower the seizure threshold, such as anorexia nervosa, bulimia nervosa, active brain tumors, or withdrawal from alcohol or benzodiazepines."
Use of alcohol or benzodiazepines while taking buproprion does not lower the seizure threshold. Abrupt withdrawal from these drugs lowers the seizure threshold.
Low to moderate alcohol intake while taking buprioprion, such that stopping for a while would not precipitate withdrawal, is not contraindicated while taking buproprion. It's still not adivsable when taking buproprion for depression, of course, because alcohol is a CNS depressant. It would tend to undermine the effects of buproprion. Buproprion can also decrease one's alcohol tolerance (so one would be impaired with less alcohol).
Heavier drinkers (and those already in withdrawal) shouldn't take buproprion because 1) heavy drinking with buproprion can increase side effects, and 2) if they decrease their intake substantially (or start to abstain), alcohol withdrawal puts them at higher risk for seizure (lowers their seizure threshold).
Benzodiazepines lower the seizure threshold. So much so, that they are first-line medications for interrupting seizures. IV lorazepam (Ativan) is typically the first med given for seizures. It is also what is given as needed for patients going through alcohol withdrawal - partly because it decreases their withdrawal symptoms (because many of the pharmacologic effects are similar to alcohol), and because it decreases their risk of seizure. Abrupt withdrawal from regular benzodiazepine usage, however, does lower the seizure threshold - similar to alchol.
1) Wellbutrin tablet package insert: http://us.gsk.com/products/assets/us_wellbutrin_tablets.pdf 
2) https://en.wikipedia.org/wiki/Alcohol_withdrawal#Treatment 
3) https://en.wikipedia.org/wiki/Benzodiazepine#Seizures 
(Wikipedia entries aren't the most authoritative, but they're more accessible than pharmacology texts for the average reader - and are sourced in the reference section).  — Preceding unsigned comment added by Gnirps05 (talk • contribs) 13:58, 7 March 2014 (UTC)
thread_title:  Contraindications - Alcohol and Benzodiazepines 

message: This article in the British Columbia Medical Journal "Bupropion toxicity with unintentional exposure or abuse: More common than you think" may be worth mentioning in this article. This is a television news article about the study. Eastmain (talk • contribs)  04:33, 20 November 2014 (UTC)
replies: text: Typically we try to use secondary sources and major textbooks rather than primary sources for content. Doc James (talk · contribs · email) 23:24, 22 November 2014 (UTC)
thread_title:  Bupropion toxicity study in British Columbia 

message: Hi, I've noticed that the lead has picked up some erroneous naming info. Bupropion is the INN and BAN (according to Martindale) while bupropion hydrochloride is the USAN for this salt specifically (no USAN for freebase bupropion is mentioned, in this source). Amfepramone was the former INN. I felt I should raise this issue here, instead of just editing the article accordingly off the bat because I felt anyone that made these changes must have had a decent reason which should be heard. Brenton (contribs · email · talk · uploads) 06:50, 30 April 2015 (UTC)
thread_title:  Source of naming info 

message: I would suggest adding the following sentence at the end of Pharmacokinetics paragraph: 
"However, a 2011 study found that therapeutic use of bupropion could and did appear to cause false positives for amphetamines."
Here's the reference: 
Casey, E.R.; Scott, M.G.; Tang, S.; Mullins, M.E. (2011) "Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay." J Med Toxicol 7:105–108 DOI 10.1007/s13181-010-0131-5  — Preceding unsigned comment added by Domineditor (talk • contribs) 01:36, 11 December 2015 (UTC)
replies: text: Edited the statement and added the ref. Seppi333 (Insert 2¢) 06:19, 16 December 2015 (UTC)
thread_title:  New(er) Research on Bupropion and False-Positives for Amphetamines 

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thread_title:  External links modified 

message: A randomized placebo-controlled double-blind crossover study of the subjective effects produced by bupropion (given at a clinical dose, i.e., in its slow-relase form, 150 mg twice daily) vs caffeine in male smokers found subjective effects, i.e.,  pronounced self-rating of "high" in 6% of the tested subjects (total sample size = 50) suggesting that bupropion, like caffeine, might be of some abuse liability in about 6% of the smokers (PMID: 15001822). I think that this is important information with respect to estimating the abuse liability of bupropion. That bupropion may be of some abuse liability for some patients/users is supported by an ever-increasing number of case reports reporting abuse (some of which are cited on the Bupropion page in wiki). Anecdotally, some intravenous drug users also do abuse bupropion, although I have no data on that.
Therefore, I would like to add that information and the reference to the bupropion page.
I did and Doc James removed my text  (I already have contacted Doc James and asked him why, he seems to be on vacation).
I am a new user, so please advise what I have to do to get that information stably inserted into the bupropion page. Thank you very much!
Stoopormundi, April 5, 2016
Stoopormundi (talk) 15:49, 5 April 2016 (UTC)
replies: text: Hi . Welcome to the editing side of Wikipedia! I hope we haven't damped your enthusiasm. Most articles on Wikipedia require reliable sources for their content, as you are probably aware (WP:RS). For medical and health related content the standard for a reliable source is higher (WP:MEDRS has the details). Essentially, we prefer meta-analyses and review articles to individual studies. The reason being that individuals studies often have conflicting conclusions. Hope this helps! Sizeofint (talk) 18:02, 5 April 2016 (UTC)

text: We can wait for this to be discussed in a review.  If it is important in the field, it will be; there are lots of reviews on smoking cessation and if this is really a significant side effect and it will be addressed.  There is WP:NODEADLINE here and high quality sourcing is important to maintain. 06:06, 9 April 2016 (UTC)
replies: text: Editors aren't always aware of MEDRS so lower quality sources can sneak in. WP:Other stuff exists talks about this a bit. We should judge content on its own merits and not based on the existence of similar content. Actually, if you could point out the references we can try to replace them with better sources if necessary. Sizeofint (talk) 07:16, 9 April 2016 (UTC)
replies: text: I looked through this and got rid of most of the primary sources.  The only one that i found and couldn't get rid of was the 2002 case report of withdrawal-symptoms. I was tempted to delete that per UNDUE (2 case reports in zillions of uses is really nothing - and i found no reviews talking about this.  it is also hard to find reviews b/c the search is messed up by the nicotine dependence use...). Jytdog (talk) 12:07, 9 April 2016 (UTC)
thread_title:  Clinical trial suggesting abuse liability of bupropion in 6% of smokers 

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thread_title:  External links modified 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: I have a problem with the summary where it says: 
"However, bupropion does not appear to have significant dopaminergic actions in humans under normal clinical circumstances."
I had a look in reference [13] it says no such thing. Actually the opposite, so this sentence should be removed.
--ADDextron (talk) 13:25, 5 January 2018 (UTC)
replies: text:  I revised the lead and rewrote the entire "Dopaminergic activity" section in this edit. Seppi333 (Insert 2¢) 04:39, 6 January 2018 (UTC)
thread_title:  The references support the dopaminergic action in humans. 

message: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916165/ Kindly update the page if you are a moderator with the following research outcome. I oppose the use of the word 'weak' as it is not referenced in any of the articles you have referenced and creates a presumption which is not based on any correlational nor cause and effect methodology. Kindly stick to science, as well expand the matter due to the number of related deaths being claimed in the USA in specific jurisdictions being that this is a point of reference for many, additionally consider updating the https://en.wikipedia.org/wiki/Methamphetamine page concurrently noting it does not reference what is referenced here. Additionally this page should be frequently updated with regular updates on all science and medical journal publications related to the same (both the medications and the article in reference to the substance.  — Preceding unsigned comment added by WM324AHI (talk • contribs) 07:41, 24 January 2021 (UTC)
thread_title:  The use of Bupropion in Methamphetamine dependence and or recovery  

message: Package insert  doesn't  say it's an antidepressant anymore,  some insurance  won't pay for it now
Weird I wonder what country you live it its still covered in the United States by my insurance  — Preceding unsigned comment added by 64.222.180.90 (talk) 19:17, 7 February 2022 (UTC)
replies: text: Certain generics are considered generic Zyban while others are considered generic wellbutrin. I’ve noticed 150mg SR being zyban and 200mg SR being wellbutrin. It’s likely just manufacturer/insurance oddities. 73.194.66.37 (talk) 00:37, 17 April 2023 (UTC)
thread_title:  Still  an antidepressant? 

message: Is true that bupropion causes a higher risk of seizures compared to other antidepressants? A reference would be good if that is the case: I see some sources saying that is a myth. 95.127.161.43 (talk) 06:44, 21 December 2021 (UTC)
replies: text: If suddenly stopped there is a risk of seizures 50.110.102.54 (talk) 02:37, 25 July 2023 (UTC)
thread_title:  Higher risk of seizures? 

message: Are bupropion and methylphenidate TAAR-active? Requesting binding profile. --0dorkmann (talk) 08:15, 11 February 2023 (UTC)
thread_title:  TAAR-activity 

message: If the half life is 10-19 hours, which several studies attest to, then why in the figure in the "History" section does it look like the half-life is only ~4-5 hours for the immediate/instant release formulation? Is it two-compartment kinetics? What is more clinically meaningful, the blood level, or the level in tissue? I'm confused... By the way, I have taken immediate release, and the chief effects seem to diminish after a few hours.. Danski14(talk) 12:12, 26 March 2023 (UTC)
thread_title:  Confused about half life figure