Talk:Resveratrol/Archive 1

message: Which wine has the most of Resveratrol? Please Advise!
answer: muscadine-derived wines. 69.87.201.3 21:25, 20 November 2006 (UTC)
thread_title:  Which wine has the most of Resveratrol? 

message: reference needed for Sinclair's claims in Nature being proved false.
62.252.49.53 20:13, 13 October 2005 (UTC)
thread_title: reference needed

message: I've attempted a major edit - whilst trying to keep the current information in it.  Any improvements welcome - this happens to be one of the group of compounds I've been conducting academic and clinical research on for the last 5 years. Daeve 20:33, 19 October 2005 (UTC)
thread_title:  Major Edit 

message: Is reservatrol a misspelling of this compound, or a separate substance? 143.252.80.110 16:02, 3 November 2005 (UTC)
replies: text: *It sure sounds like the same stuff. You will also see it misspelled reversatrol — it is not an easy word to spell or pronounce! Probably any useful and distinct points in the reservatrol article should be folded into this one and then it should be deleted, but I will defer to someone more knowledgeable. Slumberthud 01:41, 5 November 2005 (UTC)
thread_title:  Reservatrol? 

message: Too much POV (and too few references) to say that Sirtis was founded "to capitalize on the hype of resveratrol."  The only mission statement I can find says that they were founded to "pursue treatments for diabetes and other metabolic disorders" and that they are focused on histone deacetylases enzymes.
Also, I don't think that that this belongs under the heading of "Activities & Mechanisms of Action."
dpotter 14:54, 30 December 2005 (UTC)
thread_title:  Sirtris edits needed 

message: Sirtris purportedly received $85 Million in funding and does not directly sell "nutritional supplements". They are developing compounds to treat diabetes, cancer and other diseases (however, if their compounds have the side effect of life-extension and health-extension I am sure their company stands to make a small profit.)  
DestinysDoghouse 04:48, 13 December 2006 (UTC)
thread_title: More Sirtris

message: Anyone know how much resveratrol is in different kinds of foods? The bellman 10:16, 17 March 2006 (UTC)
thread_title:  different foods 

message: This ariticle, which, based on the news coverage of Sinclair's newest results will have a high readership, does not meet WP quality standards. It is full of suggestive asides, references to the supplement indusry position on this or that, and generally confused. It needs to be revised by someone who is both familiar with the research and with the clinical possibilities. A textual cleanup will NOT be sufficient. ww 17:09, 2 November 2006 (UTC)
replies: text: You are totally mistaken regarding the accuracy of the reports under "Activities and mechanisms of action".  Look them up on PubMED.  There could be more citations to in vivo (racine) models, ww has a point.  These references exist to be cited; please get on it!  Regarding CDKs, you are clearly wrong, 149.76.84.26, see seliciclib for a cdk-inhibiting anti-cancer therapeutic. ManVhv 05:04, 17 November 2006 (UTC)
thread_title: a generally unsatisfactory article

message: As I said on the  Muscadine talk page, somebody please verify what exactly the Muscadine article says; in particular, regarding the statement that both red and white muscadine wines have similarly high resveratrol contents (the online abstract doesn't mention different types of muscadine wines at all--it talks about different colored grapes having similar resveratrol content, which is interesting, but a different issue). 
Please also verify the actual numbers and comparision of muscadine to ordinary red wines, as these aren't in the abstract either. On the Muscadine page, it says 5-7 times higher than red wine. The numbers here seem to agree with that, but again, the online abstract doesn't say. --- 4.159.11.221 02:29, 17 November 2006 (UTC)
thread_title: Please verify the Muscadine resveratrol content references

message: "Johan Auwerx (at the Institute of Genetics and Molecular and Cell Biology in Illkirch, France) and coauthors published an online article in the journal CELL in November 2006. Mice fed resveratrol had better treadmill endurance than controls."
Going to the cell.com website, I cannot find any trace of this claimed article, although the news services are full of somewhat vague references to it.  Can anyone prove that it really exists, with a complete exact reference? 69.87.201.3 20:56, 20 November 2006 (UTC)
thread_title: Auwerx CELL article November 2006?

message: This probably is an inappropriate place to ask, but does anyone know of any wholesalers of resveratrol in the US or Canada? I've been trying to do some research around it for a while now but can only find Chinese companies (not that I have anything against Chinese companies, it's simply much more difficult dealing outside of North America). This is a personal interest, not a commercial venture if that matters. Cheers and apologies. -- Krinberry 22:59, 20 November 2006 (UTC)
thread_title: Wholesalers?

message: The article is all in units of mg.  But some sources use units of micromoles per litre.  This seems to be how wine will be labelled, whenever they are allowed to.  What is the conversion factor? 69.87.201.3 00:07, 21 November 2006 (UTC)
thread_title: moles

message: I just noticed that the section "chemical and physical properties" has a "citation needed" flag on the note that the trans form can isomerize to the cis form. This requires no citation. Why? Because even pretty lame organic chemists will know that stilbenes will photochemically isomerize. This is on the level of "general knowledge of the field", not something you would need a citation for. It is nice to mention it for the benefit of people with no knowledge of organic chemistry, of course.
(As an aside, if you expose stilbene (trans or cis) to UV, add a stoichometric quantity of Iodine and enough propylene oxide to quench it, and you get a Katz photocyclization to phenanthrene. Any good organic chemist would know that offhand.) --Pmetzger 22:27, 22 November 2006 (UTC)
thread_title:  No "citation needed" needed on stilbene isomerization. 

message: This article is about important chemicals, which are members of a class known as the stilbenes.  But this wiki has no article on that subject -- please write one!  And please track down some good external links and add them to this article. 69.87.204.14 18:56, 24 November 2006 (UTC)
thread_title:  Stilbenes 

message: One might take exception to the link to BIOFLU which is I believe Link #17 under the Supplement Sub Category. They claim to be an FDA Inspected Pharmaceutical Company? They appear to be from Austria and in attempting to research their website and Company I cannot come up with much that would give warrant to purchasing or buying from them. They appear to be "resellers" or packagers of resveratrol with unsubstantied claims regarding their product. 
Unfortunatley with the above mentioned FDA Ruling, Resveratrol is sold in the U.S.A ONLY as a dietary supplment (although it is a naturally occurring food substance)thus ANY supplement packaging must state that it is Red Wine Extract or Japanese Knotweed Extract and I believe it cannot state the exact amounts of Resvertrol - CIS or Trans for that matter. The scientific studies are based on TRANS-Resveratrol which is usually a percentage of total resveratrol.  
More information on the issue of Resveratrol being Glucuronidated in the Human Liver and the important issue of MG/KG of body weight in humans with metabolism being different than mice is important. The issue of adding Querctin or other Flavonids to help aid in the Bioavailabilty of Resveratrol after human oral dosing is important. 
As is the degradation of Resveratrol due to exposure to light, heat, shelf life etc. I am not a big fan of Longevinex or any other Resveratrol dietary supplement per se, since the dosage required to elicit the bodily response to mimic caloric restriction is (apparently) MUCH greater than can be obtained through regular Longevinex. This is subject to debate. Also with any of the supplements the issue of BIOAVAILABILTY in the bloodstream is very important. 
This is a great link in regards to bioavailabilty:
http://cebp.aacrjournals.org/cgi/content/full/12/10/953
An Excerpt:
"The conundrum is summarized by the following three statements: (a) resveratrol at doses as low as 200 µg/kg to 2 mg/kg elicits chemopreventive efficacy in some rat models; (b) such efficacy is supposed to be mediated via mechanisms which in vitro are engaged by agent concentrations of 5–100 µM; and (c) in light of the avid biotransformation of resveratrol, its bioavailibility in vivo is likely to be grossly insufficient to furnish agent levels compatible with those which modulate carcinogenesis in vitro." 
The LSU article is very good. However the WP article states that Pinot Noir has a higher Resveratrol content than Muscadine Wines? 
DestinysDoghouse 04:40, 13 December 2006 (UTC)
thread_title:  Links to BioFlu etc. 

message: The Linus Pauling Institute at Oregaon State University provides a superior resource for Resveratrol information. I urge anyone editing the page or with interest in researching Resveratrol to read through it. This may help with the content of the Resveratrol pages in Wiki.   
http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/
DestinysDoghouse 17:25, 14 December 2006 (UTC)
thread_title:  Great Link To Add - Superior Resource for Resveratrol Information 

message: This is a link to a PDF file which is a denial for a specific Brand of a dietary supplement which contains or appears to be labeled as Trans-Resveratrol. This ruling addresses health concerns regarding trans-resveratrol, including breast cancer cell proliferation, the saftey risk to persons taking blood thinners or anti-coagulants, potential to block the effects of prescribed medication by way of prohibiting the metabolism of prescribed drugs, supression of of angiogenesis (healing after a wound). This ruling is evidence that the FDA considers Trans-Resveratrol or resveratrol as an Investigational New Drug and not necessarily a dietary supplement. More current information may be available and the denial of application was for just this one particular "brand" of resveratrol.     
http://www.fda.gov/ohrms/dockets/dailys/02...02/80022b41.pdf 
This article also contains information.
http://www.fda.gov/ohrms/dockets/dailys/01/Mar01/030901/rpt0085.pdf
DestinysDoghouse 22:45, 20 December 2006 (UTC)
thread_title: An FDA Ruling on A TRANS-Resveratrol Labeled Dietary Supplement 2001

message: The rotating rendering of the molecule is of the cis form; the description is of the trans form. Harold f 20:35, 25 January 2007 (UTC)
thread_title: Wrong image: should be trans, not cis

message: Some issues with relative resveratrol concentrations in different wines:  
the study of LeBlanc indicates that relative to several grape varities, Pinot Noir had the highest level of *stilbenes* (compounds inlcuding cis and trans resveratrol and 3-beta-glucoside of  resveratrol (piceid)).  The table in this article lists "spanish wines" etc with no indication of what they mean by that - grapes used for example.  The citation for this table is the Pennington Nutrition Series, which looks not to be a very scholarly source, even if written by PhD- no citations etc).  Are the levels of resveratrol in "Spanish wines" really higher than the level of all stilbenes measured in Pinot Noir, which is higher than all the other grape varieties?  (12.5mg/L resveratrol 'Spanish wines" vs 2.0mg/L Pinot Noir vs 9.4 mg/L stilbenes (which includes all known forms of resveratrol) for Pinot Noir from the thesis)
To quote from the LeBlanc thesis (which is essentially summarizing previous work with several references):
"They report that Pinot Noir wines generally have the highest levels of stilbenes 
(9.39 mg/L) followed by Merlot (9.19 mg/L), Grenache (6.37 mg/L), Cabernet Sauvignon (3.23 
mg/L) and Tempranillo (3.43mg/L).  Romero-Perez et al., in a 1996 study of resveratrol and 
piceid isomers in Spanish white wines, reports that isomers of both compounds are present in 
all samples and the levels range from 0.46 to 1.24 mg/L total stilbenes.  This is consistent with 
previous reports of lower levels in white wines.  "''
I think this area on content of resveratrol needs to be improved, in particular, making it clear which forms of the compound are being discussed (as the biological activity and health  benefits of each form are not clear) AND which grapes are used.Type3secretion 02:39, 24 January 2007 (UTC)
thread_title:  cmnt moved to bottom of page 

message: In the very last section, link #4 is
http://www.relentlessimprovement.com/catalog/dual-action-cruciferous-vegetable-extract-with-resveratrol.html
and returns a 404 error.
Misterakko 07:58, 10 February 2007 (UTC)
thread_title: Broken link

message: Is it pronounced rez-VERA-trol, REZ-vair-atrol or REZ-vur-atrol?  --Karuna8 00:39, 11 February 2007 (UTC)
thread_title:  Pronunciation 

message: Under WP:RS this may not be posted to the article, however there is an interesting blog entry about a recent presentation by David Sinclair called: Be fat, the wonder drug will save you.Apparently Sinclair calls his mice on resveratrol the “Lance Armstrong” mice because they have such well-developed muscles, even though some of them are "chunky" according to the blog author. The author also mentions that Sinclair said that human trials on resveratrol, and other drugs developed from it, "were very, very encouraging". Again under WP:RS this information may not be used in the article. Chrisbak 19:43, 3 April 2007 (UTC)
thread_title:  David Sinclair talks about his "Lance Armstrong" mice, and mentions human trials are encouraging 

message: The animated image on this page is of the cis and not the trans version of the molecule. —The preceding unsigned comment was added by 24.199.89.159 (talk) 18:30, 6 April 2007 (UTC)
thread_title:  Animated image is wrong 

message: There have been several complaints posted above about the information on supplements in the article, and therefore I propose to significantly condense the Supplements section and move it to the bottom of the page. Eventually it is likely to be deleted. Information in that section having to do with physiological effects will be moved to that section, along with necessary references. I will also add the following information to beginning of the supplements section: "Upon exposure to light, heat or oxygen, trans-resveratrol may convert to the less stable form - cis-resveratrol."
Also there have been several complaints about the rotating image of cis-reseveratrol - that includes by a reviewer at the top of this page. Therefore I propose to move the rotating image from the article to this page pending deletion.--Chrisbak 15:15, 1 May 2007 (UTC)
thread_title: Proposal to condense and move the "Supplements" section, and delete the rotating image

message: Just wanted to share something I just noticed. There should be more research into similar chemicals, seems they can do so many things and be very beneficial for you. --x1987x(talk) 05:14, 10 May 2007 (UTC)
thread_title:  Molecule similarities?! 

message: Quoting from the article heading titled "Life extension and anti-aging":
"Experiments from the Harvard laboratory of David Sinclair (Biologist) published in 2003 the journal Nature demonstrated that resveratrol significantly extends the lifespan of the yeast Saccharomyces cerevisiae. [45] Dr. Sinclair then founded Sirtris Pharmaceuticals to commercialize resveratrol or related compounds as an anti-aging drug.
".... The authors observed that "[resveratrol's] supplementation with food extends vertebrate lifespan and delays motor and cognitive age-related decline could be of high relevance for the prevention of aging-related diseases in the human population."[47] Later in 2006, a report in the journal Nature by Sinclair's laboratory showed that the compound improves health and survival of mice on a high-calorie diet[48]."
This Wikipedia article is devoid of scientific criticism.  The study reported in Nature (2006) did not see any lifespan improvement in mice fed a standard diet + resveratrol compared with controls fed standard diet alone, and these were wimpy inbred lab mice -- not wild mice.  So the results are not very encouraging for otherwise healthy humans.  That is not to say the results of the study are worthless, just that this compound per se is unlikely to be anything special for human longevity. Speculator 20:10, 14 May 2007 (UTC)
thread_title:  Alleged anti-aging properties 

message: Substituted at 21:59, 3 May 2016 (UTC)
thread_title: Assessment comment