Talk:Catenin beta-1

message: *Description of function in linking ECM to the actin network
*More focused description of the activities of beta-catenin in the wnt signaling pathway, use concrete examples and genes affected
*Role in cancer transformation, how the signaling pathway is changed
*How beta-catenin mediated signals help to establish body axes and other features in embryos
Bgumbardo (talk) 17:16, 14 March 2013 (UTC)
thread_title:  Possible topics for expansion of the article 

message: β-catenin contributes to early vital events in embryonic formation by determining the dorsal-ventral axis of the developing organism. The induction of this activity is mediated by the wnt pathway and is established during early to mid epiboly. The cells of the future dorsal regions of the embryo express significantly higher levels of β-catenin in both the cytoplasm and the nuclei. Cells with increased wnt signaling degrade β-catenin to a lesser degree and cause increased accumulation in the nucleus. Within the nucleus,β-catenin binds to TCF and enables it to activate transcription of selected genes. The transcriptional regulation activities of β-catenin exist in a separate protein domain from its functions in cell adhesion. The overexpression of wnt and other signaling pathways can cause anchorage-independent growth in mature organisms, leading to cancers. Depalmal (talk) 00:52, 23 March 2013 (UTC)
thread_title:  Work Space for Introduction 

message: Bienz,M. β-Catenin: A Pivot between Cell Adhesion and Wnt Signalling, Current Biology, Volume 15, Issue 2, 26 January 2005, Pages R64-R67, ISSN 0960-9822, 10.1016/j.cub.2004.12.058.
(http://www.sciencedirect.com/science/article/pii/S0960982204010413) Yanchen91 (talk)
Brembeck, F.H., Rosário, M., Birchmeier, W. Balancing cell adhesion and Wnt signaling, the key role of β-catenin, Current Opinion in Genetics & Development, Volume 16, Issue 1, February 2006, Pages 51-59, ISSN 0959-437X, 10.1016/j.gde.2005.12.007.
(http://www.sciencedirect.com/science/article/pii/S0959437X05002236) Yanchen91 (talk)
Gregory M. Kelly, Deniz F. Erezyilmaz, Randall T. Moon Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of β-catenin Mechanisms of Development, Volume 53, Issue 2, October 1995, Pages 261–273
Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, Kemler R."Lack of beta-catenin affects mouse development at gastrulation" (Nov. 1995) Development (11) : 3529-37   — Preceding unsigned comment added by Depalmal (talk • contribs) 17:02, 4 April 2013 (UTC)
thread_title:  Potential Sources 

message: Peer Review
Introduction paragraph
In this introduction paragraph I added a few words which I thought allowed the paragraph to flow smoother. I also think that there could be wikilinks used for CTNNB1, armadillo, and early embryonic development because as a reader who may not be familiar with such terms, trying to get more background information would be beneficial to understanding the article as a whole.
Structure
This paragraph had a good and plentiful use of wikilinks, sufficient and clear information. However, although there was a wikilink for alpha-catenin here, the section preceding this one also included something about alpha-catenin so I  think the wikilink should have been placed in the preceding section rather than in this one.
Role in Cell to Cell Adhesion
While this paragraph is very informative, clear, with smooth transitions from one sentence to the next, it could also use more wikilinks for terms such as gastrulation, mesoderm, transcription factor.
Role in Wnt Signaling
There were no citations used in this paragraph of the article. I replaced a few words in the sentence bolded to allow the ideas to flow smoother because before it had been two very short fragmented sentences.
The rest of the article contained a good number of citations as well as wikilinks. The transition in the paragraphs were also very smooth and easy to follow. The entire article as a whole was great--it shows a great depth of research, use of time, and use of space. One thing I would suggest is to read the article and ask yourself if someone who may not be as familiar with many of the mentioned terms in this article would be able to completely understand all of the terms used. Thinking about this would help you incorporate even more wikilinks. I would also suggest an expansion of the introduction--there is definitely more background information that the reader should know beforehand! External links should also be used--there were none in this article and I believe you need at least six of them! I think the last image used in the article should either be made larger or replaced because it is very difficult to see all of the details unless you click on the actual image.
Sungta (talk) 01:34, 13 April 2013 (UTC)
thread_title:  Peer edit 

message: I will add a new, improved framework to this article. It will take some time: please, do not be impatient. It will incorporate most of the already existing content, but I will change the titles and remove the images to substitute them with newer, more enlightening figures. Though many of the cell biologists may find the new framework not for their taste (with a lot of structural/molecular details), please do not undo these changes. Instead, feel free to add cell biology related content & references. The draft is already on its way. I have put much work to make something nice for you, guys! Bubus (talk) 20:54, 29 June 2013 (UTC)
replies: text: Wow!  WikiDragon sightings are exceptionally rare these days. This is particularly impressive example resulting in huge improvement in this article. Keep up the great work! Cheers. Boghog (talk) 14:05, 30 June 2013 (UTC)
thread_title:  Major update: Upgrade of the article to meet scientific standards 

message: I was initially taught to pronounce catenin as "cat'nin" just like the word adeno (as in adenocarcinoma) is pronounced "ad'no" not "ad-e-no" or "adeeno."  You don't say "adeenocarcinoma" so you also don't say "beta cateenin."  But it seems lots of people pronounce the e in this word (either short or long).  This article did not help clarify this simple yet important point.  Does anyone know the correct pronunciation?   162.82.215.197 (talk) 13:24, 13 August 2013 (UTC)
thread_title:  Pronunciation? 

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thread_title:  External links modified