Talk:Cyclobenzaprine

message: crime of possession of prescription drug without prescription see Florida statutes 499.03(1)
Interesting Reading - While the Florida statue does appear to prohibit possession of "Habit forming" prescription drugs, Federal Law does not require a "prescription" to possess a drug - only to possess controlled substances.  Most likely in this case Federal Law would supersede State law in any appeals of a conviction.  So unless Florida plans on adding Cyclobenzaprine to it's CSA schedule, I cannot foresee this statue as being enforceable.
That's not how laws work, anonymous/unsigned person just above this. Florida can charge you with a state crime that differs from similar federal crimes and it's not an issue so long as the state crime is not prevented by a federal law/regulation/constitution. Reallypablo (talk) 21:06, 30 April 2014 (UTC)
thread_title:  legality 

message: Is this drug a benzo such as valium?
:Assuming you mean "benzo" as the short form of benzodiazepine then no. Cyclobenzaprine is more closely related to tricyclic antidepressants <3 horsedreamer 06:13, 27 February 2008 (UTC)
thread_title:  ??? 

message: One of the side effects listed is vision damage. Can someone further research that and explain it a bit more? I'm currently taking cyclobenzaprine for muscle spasms in my jaw which I dislocated last month, and I noticed that my vision is sometimes blurry or not very clear. Is that a sign that it is damaging my vision? Any further research on this side effect will be appreciated.
It could be related/caused by IOP (Increased Ocular Pressure) which is why they have warnings for people who have IOP or glaucoma.
I added a "citation needed" for that statement.  The worst I've been able to find is "blurred vision" which resolves with discontinuation of the drug... hardly "vision damage".  If it was, long term use of all the tricyclic antidepressants would have the same warning.
ૉ
I have previously read reports that state that long term Flexeril use (over 3 weeks) causes vision damage in some persons as a resultant of its CNS depressant effects and the vision damage is caused by "migrainous visual disturbances." Causing what some describe as "dirty vision", translucent geometric hallucinations or bright flashes of light. After cessation of SMR drugs the effects may decrease after 7 years or last indefinitely. It's not caused by IOP, but by its effects on the visual cortex. 
See the subspecialty- Neuroophthalmology for more information. I will find the sources for this info and restore it. 
76.23.15.109 (talk) 17:40, 15 December 2011 (UTC)
thread_title:  Side effects 

message: Please include substrate info especially for CYP2D6 substrates due to the significant portion of the population that are poor metabolizers and can experience severe side effect and unintentional overdoses. Cyclobenzaprine is a substrate of CYP1A2 (major), 2D6 (minor), 3A4 (minor) Clairidge 01:43, 6 November 2007 (UTC)
thread_title:  Include substrate info 

message: The link under "References" is for a commercial product that is not exactly the same as this drug.  I'll find a better one.  --AndyFinkenstadt (talk) 18:23, 1 February 2008 (UTC)
thread_title:  Possibly PROD "references" link 

message: At the beginning:
Cyclobenzaprine doesn't seem to be particularly popular in recreational drug-using communities, despite having an arguably high potential for abuse.
At the end:
It is important to note that cyclobenzaprine is not the only muscle relaxant with increased intensity of abuse. Soma, or carisoprodol, is a muscle relaxant that carries increased abuse potential.  A handful of states such as Georgia have classified the drug as a Schedule IV controlled substance.  This classification includes the majority of benzodiazepines, non-benzodiazapine sleep agents, and dextro-propoxyphene (a mild narcotic analgesic).
These are plainly in conflict, as the latter implies that cycloenzaprine is a popular recreational drug and the first one says it's not.  Moreover, the second one makes it sound as though its increased abuse has already been mentioned, which it has not up to that point.  —Preceding unsigned comment added by 76.21.104.5 (talk) 08:28, 3 May 2008 (UTC)
thread_title:  Incoherency in Abuse section 

message: Amrix, Celphalon's new time-released version of cyclobenzaprine costs over $500 USD per month.  The same amount (mg/day) of generic cyclobenzaprine is about $20 USD per month.  A script for this new time-released version of cyclobenzaprine cannot be filled generically because the dosing amounts / periods cannot be translated by the pharmacists.  —Preceding unsigned comment added by 68.195.34.150 (talk) 19:24, 24 May 2008 (UTC)
thread_title:  Pricing Scandal? 

message: The statement that cyclobenzaprine should not be taken with SSRIs is not entirely correct. The cited source (Keegan et al, 2006) indicates hyperserotonemia with an M.A.O.I (phenelzine). This fits the contraindication profile of M.A.O.I. drugs in general. Keegan et al also found some risk between cyclobenzaprine and a relatively new SSNRI, duloxetine. They later mention complications with bupropion (which does not have a serotoninergic effect, but rather effects norepinephrine and dopamine http://www.drugs.com/pro/bupropion.html).  Cyclobenzaprine focuses mainly on norepinephrine (which may explain why there were complications with bupropion and duloxetine). Neither of these drugs are SSRIs, but they both affect norepinephrine. Since Keegan et al have not been cited by any other peers, regular caution might be warranted when taken with seratoninergics including SSRIs. Of course, since Wikipedia is not a primary source for medical advice, perhaps we should avoid advice about when or when not to take the medication. Perhaps the article should state:
Cyclobenzaprine has major contraindications with monoamine oxidase inhibitors (MAOIs). Some studies have also found increased risk of hyperserotonemia, or seratonin syndrome, when cyclobenzaprine was taken with duloxetine, an SSNRI.Keegan MT, Brown DR & Rabinstein AA (2006). Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. Anesth Analg. 103: 1466-1468.  —Preceding unsigned comment added by General Ludd (talk • contribs) 01:34, 4 March 2009 (UTC)
thread_title:  SSRI contraindications 

message: I have upgraded this to a C-class, after the request for reclassification. I have made some minor edits of my own, but the 'Indications' section needs some references. I'll work on getting some, as well as some more info on the missing topics listed at the top of this page. Perspeculum (talk) 14:24, 8 January 2010 (UTC)
thread_title: Quality Scale

message: This drug does nicely with schizophrenia caused ministrokes, or electric neck muscle spasm schizophrenia which has decided to make its attack directed at the central nervous system. It does "though", decrease the effectiveness of zolpidem tartrate if taken together. Sometimes, if you get a good pill that has the chemical proper, you get a total decrease in the electric spasm feeling iin the brain that is mostly thought by me to be microbes ramming headlong into the white matter to increase relationary disorder, or disassociation disorder, "or so it seems". It seems to make some schizobes angry, but they get used to being tired in the high end sedative treated schizophrenia days.  — Preceding unsigned comment added by Vilignoble (talk • contribs) 00:22, 16 June 2011 (UTC)
thread_title:  Cyclobenzaprine and schizobial nanoseizures 

message: could this be use for cramp due to your monthly period  — Preceding unsigned comment added by 71.117.107.45 (talk) 11:28, 20 May 2014 (UTC)
thread_title:  monthly period 

message: Discussed here  Listing all ingrediants some brand name products is too much for a general encyclopdia IMO.Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:11, 21 August 2014 (UTC)
thread_title: Excess detail

message: This entry had contradictory recommendations -- for and against its use in the elderly. The NCQA recommendations against it was kind of buried in the "Side effects" section. 
There was a horrific story about an 88-year-old woman who died as a result of being given cyclobenzaprine: 
http://archinte.jamanetwork.com/article.aspx?articleID=2398403#
Perspective | July 27, 2015 Less Is More
“Mom, You Have to Trust Me” 
Mary K. Brennan-Taylor
Consumers Union Safe Patient Project
JAMA Intern Med. Published online July 27, 2015. doi:10.1001/jamainternmed.2015.3659 
(Mother, 88, active, pain in neck and shoulders, went to ED, dx osteoarthritis, rx muscle relaxant cyclobenzaprine HCl (Flexeril), on Beers Criteria list, should be avoided in older adults, can cause confusion, delerium, cognitive impairment. Pain subsided, never took it. 1 week later, right knee stiff, swollen, painful, problems walking, stairs. PCP suspected gout, referred orthopedic specialist, who recommended hospitalized so fluid could be drawn from knee, questionable. Hospital gave cyclobenzaprine, discharged to rehab for PT. 12 days, lethargic, confused, nauseated, hallucinating. Discontinued cyclobenzaprine, continued to hallucinate. Hospital, tx dehydration and delerium, given drugs for confusion and agitation, delerium worsened. Geriatrician said medications were causing sx, delerium often has prolonged course. But mother died of health care-associated infections.)
That's arguably not a WP:RS, although it's a legitimate peer-reviewed case report and the WP entry has individual case reports right now. The source the author cites is: 
Potentially inappropriate medications for the elderly according to the revised Beers criteria. 2012. Duke Clinical Research Institute website. https://www.dcri.org/trial-participation/the-beers-list/
http://www.americangeriatrics.org/files/documents/beers/2012AGSBeersCriteriaCitations.pdf
I added that, although it should probably be put together with the NCQA reference. --Nbauman (talk) 21:57, 31 July 2015 (UTC)
thread_title:  Strong evidence against use in elderly 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: Since the following statement applies to all Rx drugs, it doesn't seem necessary. Moreover, it suggests that cyclobenzaprine is virtually a controlled substance—such a statement doesn't exist with the other common (non-controlled) muscle relaxants tizanidine, metaxalone and chlorzoxazone. I'm not aware of any jurisdiction or guideline where cyclobenzaprine is a controlled substance.
(This is from the formulations section and likely the topic of "legality" re Florida statutes above.)
I believe this should be cut. Opinions? — βox73 (৳alk) 22:12, 29 April 2018 (UTC)
replies: text: I just took it out. Cyclobenzaprine is not treated differently from other legend drugs under US law, so this is just general information about the prescription drug system. It definitely doesn't belong in an article about a specific drug. — Tartan357  (Talk) 03:17, 17 July 2020 (UTC)
thread_title:  Cut "possession without Rx illegal" sentence? 

message: What are the different milligrams this medication comes in? 172.58.128.182 (talk) 03:45, 13 May 2022 (UTC)
thread_title:  Dose, different strengths 

message: The structure of the compound is wrong. It is missing the exocyclic double bond in the seven-membered ring. 199.204.53.82 (talk) 16:38, 14 April 2023 (UTC)
thread_title:  Structure