Talk:Cadherin

message: From the article "Cadherins within one class will only bind to themselves." I think this is untrue in general. Please see Prakasam et al. (2005) PNAS (doi:10.1073/pnas.0606701103). The authors present bead aggregation and force displacement measurements on C-, E-, and N- cadherin from Xenopus, canine, and chicken, respectively. The different forms bind to each other and heterophillic adhesion strength is not significantly different from homophillic adhesion strength.
I concur with the above concerns, and removed/replaced the offending statement with one with substantially more detail and a few citations.Rritterson (talk) 03:34, 16 December 2008 (UTC)
thread_title: Untitled

message: Should there be something on E-cadherin's significance in breast cancer? See Tan DSP et al. (1999). The biological and prognostic significance of cell polarity and E-cadherin in grade I infiltrating ductal carcinoma of the breast. Journal of Pathology, 189(1), 20-7.  —Preceding unsigned comment added by Bondegezou (talk • contribs) 14:59, 5 September 2007 (UTC)
thread_title: Cancer

message: I added the refimprove and expand tags to the article. Specifically, the article has several papers listed as further reader, but no inline citations, despite the fact there are several unreferenced statements in the article. In addition, several details about cadherin are currently missing, including discussion on the calcium binding requirements, the cadherin lateral and adhesion interfaces as debated between biochemical assays and x-ray crystallography, discussion of cadherin as a signaling molecule (e.g. activation of Rac and PI3-K), as well as the interplay between cell polarity, mature cell-cell contacts and cadherin as architect. It would be helpful to have an expert on the topic expand where he/she can, but in the interim I will attempt to add what I can. Rritterson (talk) 03:34, 16 December 2008 (UTC)
thread_title: Template Tags

message: These biological articles are fascinating, but way to technical for me.  Would it be possible to have a popularized section and bring it down to a laymen's level?  If not, is there a good popularized book that might be placed into the "Further reading" section? I've always wondered how cells group together and know where to locate themselves in the body. Pknkly (talk) 15:28, 2 May 2009 (UTC)
thread_title:  Popularized summary section 

message: I generally would agree with Rritterson within my own area of expertise but -- I usually pride myself on being able to parse just about anything and was aghast to find I could make neither head nor tail of this article. (I got here as I was googling my way through the records relating to a recent hospital visit.) 
Then, just as I was leaving in despair, I found something relating to my question: "used by pathologists to diagnose different kinds of breast cancer. When compared with invasive duct carcinoma, E-cadherin expression is markedly reduced or absent in the great majority of invasive lobular carcinomas when studied by immunohistochemistry.[7]" It's pretty buried and though I can see that it is probably more important to explain what it is than to go into its uses, and that this is probably where the article should start, wow. Is it a protein? hormone? Animal, vegetable or mineral? 
As my contribution to the article I will ask if the sentence cited above cannot without loss of meaning be reworded as: "Pathologists can distinguish invasive duct carcinoma from invasive lobular carcinomas using E-cadherin expression; in lobular carcinomas it's absent or much lower than in invasive duct carcinomas.[7]" If so I believe my version is clearer.  —Preceding unsigned comment added by 12.7.169.9 (talk) 04:29, 26 September 2010 (UTC)
thread_title:  Help help 

message: I removed a recent addition, whereby an author removed a paragraph of text in the article and added a citation to his own work.(Presumed from username similarity to the author of the cited article) In general, I suspect wikipedia frowns upon self-promotion of one's own work, though if I am wrong, someone else may revert my reversion. Also, if the author of the cited review believes it to be important, it might be useful to put a comment on this talk page, so that other, third-party contributors could assess its merits and add a citation to it, if necessary. (Apologies for reverting the edit while not signed in) Rritterson (talk) 08:02, 10 May 2009 (UTC)
thread_title:  Undone edits 

message: Should there be a mention that a genome wide study hints at cadherins being possibly linked with autism?
Wang K et al. (2009). Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature. 459, 528-533
(http://www.nature.com/nature/journal/v459/n7246/full/nature07999.html)  —Preceding unsigned comment added by 159.92.100.162 (talk) 13:55, 18 November 2010 (UTC)
thread_title:  Autism 

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thread_title:  External links modified 

message: Hey, I agree with digging more into breast cancer but cancer in general. I'm going to be working on the relation between cadherins and tumors leading to cancer I just need to find more sources on it.  — Preceding unsigned comment added by AshleyRZ123 (talk • contribs) 06:43, 18 February 2019 (UTC)
thread_title:  Tumors and cancer in general 

message: — Assignment last updated by Liamoconnorfloridatech (talk) 01:04, 4 March 2024 (UTC)
thread_title: Wiki Education assignment: Developmental and Molecular Biology Spring 2024