lflage/wiki-talks huggingface dataset:
Talk:2-Arachidonoylglycerol

message: The text is a simple copy from http://www.caymanchem.com/app/template/Product.vm/catalog/62160. Someone should change it.  —Preceding unsigned comment added by 82.166.182.11 (talk) 16:35, 3 November 2007 (UTC)
thread_title: Copyright violation?

message: The IUPAC name is for a carboxylate group but the article is for the di-carboxylic acid. is there a reason for this?--ChemSpiderMan (talk) 23:58, 5 January 2008 (UTC)
replies: text: i'm pretty sure the IUPAC name is correct.  the article is about a diol, not a di-carboxylate.  the IUPAC name is (5Z,8Z,11Z,14Z)-1,3-dihydroxypropan-2-yl icosa-5,8,11,14-tetraenoate - the first part is 1,3-dihyroxypropane which is the glycerol-backbone, and the second part is icosa-5,8,11,14-tetraenoate which refers to the arachidonic acid (aka icosatetraenoate).  does that make sense?  Roadnottaken (talk) 02:08, 6 January 2008 (UTC)

text: done.  thanks :) Roadnottaken (talk) 05:01, 6 January 2008 (UTC)
thread_title:  IUPAC Name incorrect 

message: Is paternal bovine different than maternal bovine milk?
Shjacks45 (talk) 10:23, 15 July 2008 (UTC)
thread_title:  milk 

message: Erm... I understand that this chemical is basically a neurotransmitter, but what does it actually do? Would anyone be willing to tell me or point me to a link that explains it in terms a high school C-grade physiology student could understand? EvangelionUnit01 (talk) 22:13, 30 March 2011 (UTC)
replies: text: 2-AG acts upon the CB1 and CB2 receptors in the brain and body. Once you find out what the purpose of those receptors are, you'll have your answer.  - Gunnanmon (talk) 11:33, 11 January 2012 (UTC)
thread_title:  Function
Talk:Hexachloroethane

message: Under WHAT specific conditions does this have a half life of 36 minutes?  "Reductive" is too vague. Walkerma (talk) 03:20, 15 January 2009 (UTC)
thread_title:  Details of half-life 
Talk:Bahnhofstrasse

message: Does anyone else agree with me that there shouldn't be a list of shops in this article? I feel that unless the list of shops if fully complete, it is merely advertising for the shops that are listed. What do you think? Lostvalley 10:57, 12 July 2007 (UTC)
replies: text: The list of buildings at :de:Bahnhofstrasse_(Zürich)#Wichtige_Bauten might be more suitable.  -- User:Docu
Afaik, Bahnhofstrasse starts at Bürkliplatz and ends at Hauptbahnhof. House numbers are higher, the closer to the trainstation.  — Preceding unsigned comment added by 31.10.148.25 (talk) 14:02, 14 July 2016 (UTC)
thread_title:  List of Shops 
Talk:Propionyl-CoA

message: Planning to expand this page and add more information. Outline has been included below. Any suggestions or constructive criticism would be greatly appreciated. 
Outline for addition
1. Add reaction with Propionyl-CoA carboxylase
include picture and short description
Link: https://www.sciencedirect.com/science/article/pii/S1096719217305322
Metabolic intermediates
Link: https://www.sciencedirect.com/science/article/pii/S1096719217305322
2. Expand on production through beta-oxidation of odd chain fatty acids
add reaction
include figures
link: https://www.ncbi.nlm.nih.gov/books/NBK22387/
3. Expand on production by alpha-ketobutyric acid
add reaction
link: https://pubs.acs.org/doi/abs/10.1021/jf00058a012
4. Expand on production by metabolism of isoleucine and valine
link: http://www.jbc.org/content/189/1/277.long
5. Expand on production from conversion of cholesterol to bile acids
link: http://www.eurekaselect.com/58839/article
All these changes would include figures and the metabolic pathway.
6. Possible expansion of metabolism in plants and insects if more information is needed
Biochem153aj (talk) 04:18, 5 May 2019 (UTC)
thread_title: Untitled
Talk:Société Nautique de Genève

message: First section, catamarans developed specifically for some unspecified lake ;-)  
I think it says the link the quote is from is dead... almost certainly has to be Lake of Geneva...?
thundt (talk) 16:08, 27 August 2012 (UTC)
replies: text: The article says "the lake", so I think that it is clear that it refers to Lake Geneva.  Thanks for spotting the dead link, I have fixed it.--Gautier lebon (talk) 07:51, 28 August 2012 (UTC)
thread_title:  Which lake?  Lake of Geneva, right? 
Talk:Protoporphyrin IX

message: The protoporphyrin IX structure is wrong. This structure is the HEM B without the iron atom !!!!  — Preceding unsigned comment added by Cianitomas (talk • contribs) 14:23, 20 July 2012 (UTC)
thread_title:  Wrong image 

message: The synthesis presumably also takes some oxidizing compound as input (?), and yields some byproducts ?)  For the benefit of non-specialist readers, those should be shown. I could add them to image, if someone told me what they are. --Jorge Stolfi (talk) 01:01, 9 March 2019 (UTC)
replies: text: Even specialist readers would benefit.  I revised all of the porphyrin articles a couple of years ago, but apparently I overlooked the stoichiometry.  It was not easy to find good sources. I will look again. --Smokefoot (talk) 01:29, 9 March 2019 (UTC)
thread_title:  Reactants and byproducts of synthesis 
Talk:Sphingosine-1-phosphate

message: In Firefox 3.5, :File:Sphingosine 1-phosphate.svg, especially as displayed in the article, is unreadable since the letters denoting atom types overlap with each other. -- Beland (talk) 21:53, 20 July 2009 (UTC)
thread_title:  Image rendering problems 

message: The link to sonepcizumab in this article redirects to itself. Since this is an independent chemical entity, it deserves its own page. Aglo123 (talk) 23:40, 31 January 2017 (UTC)
thread_title:  Sonepcizumab needs its own page 

message: says idronoxil is an S1P inhibitor (and might help immuno-oncology) - Need RS. - Rod57 (talk) 09:54, 28 July 2020 (UTC)
thread_title:  Another S1P inhibitor 

message: This passage is not supported by a citation: "A research team, led by a scientist at Weill Cornell Medical College, has discovered that red blood cells perform a second vital function: angiogenesis. Given its role in creating new blood vessels, scientists recognize S1P as vital to human health — and a player in some diseases, such as cancer. And although S1P is known to be blood borne, no one realized until this study that S1P is supplied by red blood cells to control blood vessel growth." This reads as if it were added by one of the authors on the study and is worded confusingly. The paper should be cited and the text revised to something like "A study found red blood cells to be sources of S1P that contributes to angiogenesis." 75.164.131.65 (talk) 21:11, 6 February 2024 (UTC)
thread_title:  unsupported claims on this page
Talk:Phenyl salicylate

message: This article originally attributed the first synthesis of phenyl salicylate to the Polish chemist and doctor Merceli Nencki (1847–1901), who supposedly discovered this compound circa 1883.  A number of sources claim this, but none of them cite their original source for this information.  There are also sources that claim that Nencki synthesized phenyl salicylate in 1885, but, again, there's no documentation to substantiate that claim.
However, there is documentation that the German chemist Richard Siefert (1861–1919) synthesized it in 1885, and he claimed to have been the first person to have synthesized it.
However, the U.S. patent of 1886 for the preparation Salol — which was a commercial name for phenyl salicylate and which is supposedly a contraction of "SALicylate of phenOL" — includes both Nencki and Siefert.  The inclusion of both investigators in the patent suggests that they both had a legitimate claim on Salol.  
On the basis of the available evidence, I surmise that Nencki synthesized phenyl salicylate, realized (and investigated) its potential pharmaceutical applications, and therefore didn't publicize his discovery; whereas Seifert didn't realize phenyl salicylate's potential applications — as evidenced by the fact that his 1885 paper devotes little attention to the new compound — and therefore did publish his findings.
I'm making many edits to this article as I unravel the story of this compound.
VexorAbVikipædia (talk) 11:52, 25 April 2020 (UTC)
thread_title:  Sorry for the many edits to this article
Talk:River crossing puzzle

message: Hey, 
I'm a new user and I just noticed that the puzzle could be edited a little. I changed the word goose to chicken because that was the way my logic teacher had explained at my University. However, it was deleted. I was just thinking we should provide both versions of the puzzle - fox, goose, and beans as well as fox, chicken, and grains. 
Thanks!
--Kwells1989 (talk) 20:12, 24 May 2011 (UTC)
replies: text: It's not actually a different puzzle, so I don't think it merits being listed as a separate entry in the list of puzzles. Our Fox, goose and bag of beans puzzle article mentions your variation, but "we should change it to match the way my local instructor presented it" seems to me a pretty unconvincing reason: lots of people are likely to have seen the puzzle presented in lots of different ways (to me, the wolf/goat/cabbage variation is more familiar). But maybe we can at least state here, in a single entry, that other variations are known. —David Eppstein (talk) 21:35, 24 May 2011 (UTC)
thread_title:  Suggest change to logic problem 

message: I suppose more complex types of these puzzles could benefit from graph-theoretic methods, dynamic programming, or integer programming, as you say. But such versions as the fox, goose and bag of beans as stated have a forced solution, that is, once you start to outline a solution, you have no options other than to solve it. There are simply no other moves allowed by the rules…you literally cannot fail.
For example, the rules tell us that if two things are left together, it must be the fox and the beans. So there is no other first step but to take the goose across. Then what? If you next take the fox across, you must bring the goose back…or if you take the beans across, you must also bring the goose back. Either way, the goose comes back…there is no other way to do it. And the rest of the solution follows in like manner.
And what is like manner?  Well, suppose you take the fox over as the second step…you have no choice but to take the goose back. Then what? You just brought the goose back, it makes no sense to bring it over again, so you bring the beans over. The beans can safely stay with the fox, so you can now bring the goose back over and you’re done. True, the second step had two options, but both had the same result, bringing the goose back. At each step, you couldn’t not solve it if you tried!
The true key is the realization that you must temporarily undo something that you previously did. This is a tactic also used in solving square 15 puzzles.  71.162.113.226 (talk) 00:16, 31 January 2021 (UTC)
thread_title:  forced solutions
Talk:Phosphorylethanolamine

message: Add : more properties (solubility, melting point ...), how it is made, any natural sources, industrial or other uses. - Rod57 (talk) 16:25, 2 April 2016 (UTC)
thread_title: To do

message: Article could at least mention : Brazil bill would legalize renegade cancer pill. Summary
"A showdown over a controversial cancer therapy has intensified, pitting Brazil's scientists against its congress. Last week, responding to a clamor from politicians and desperate patients, the congress voted to legalize the production and distribution of synthetic phosphoethanolamine, even though the putative cancer drug has not been clinically tested or registered with the Brazilian Health Surveillance Agency. Scientists blast the legislation as a travesty. Apart from patient testimonials and a few preliminary studies in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the "cancer pill" or "fosfo." Several thousand patients are estimated to have taken it. Brazilian President Dilma Rousseff has until 13 April to decide whether to sign the bill into law." - Rod57 (talk) 16:05, 2 April 2016 (UTC)
thread_title:  Controversy in Brazil 

message: I've notified Wikipedia:Fringe_theories/Noticeboard#Brazilian_cancer_pill. fgnievinski (talk) 16:12, 9 April 2016 (UTC)
thread_title:  Fringe theory 
Talk:Titanium isopropoxide

message: Are 22 alternate names really necessary (see bottom of article)? Not even the pages for more well-known, complex substances have so many alternate names. To me it seems like the names were put there to make up for lack of content, but really, only a few are needed, as the rest are basically variations. I'd feel at odds choosing which to keep, so instead, I'll just piss and moan about it here.. Mr0t1633 (talk) 04:36, 3 September 2009 (UTC)

message: Why get rid of disambig link at the top for the Transatlantic Trade and Investment Partnership? It helps readers find what they're looking for, and the first thing you see when you google "TTIP" isn't a chemical but rather the proposed trade agreement. Chris (talk) 17:17, 18 September 2013 (UTC)
thread_title: Transatlantic Trade and Investment Partnership (TTIP)
Talk:List of boxing triple champions

message: He is listed belowe where it states when he won the titles, but he is missing from the table.Mahussain06 (talk) 11:23, 8 October 2017 (UTC)
thread_title:  Adrien Broner 

message: I'll be removing a lot of the content in this article at some point. When somebody clicks a link of "...is a world champion in three weight classes", I presume the reader is looking for a simple list of boxers who have won major world titles in three weight classes, not a long list, short list, long list, short list with minor titles included, long list with minor titles included and whatever else is listed within the six different lists in the article. As well as seeming completely unnecessary, the article is far WP:TOOBIG. Almost double the size of the limit recommended for an article that "almost certainly should be divided". – 2.O.Boxing 13:04, 11 January 2021 (UTC)
thread_title: Trimming the article

message: These need to be removed per MOS:BOXING/WEIGHT: 
. – 2.O.Boxing 11:16, 12 January 2021 (UTC)
thread_title: Lineal titles
Talk:Ketazocine

message: The current image (as of 2014-02-12) is the enantiomer which is not active as an opioid. You want the mirror image. The current image also leaves the chirality of one carbon ambiguous, but that is probably fine.Fluoborate (talk) 05:52, 12 February 2014 (UTC)
thread_title:  The image shows the inactive enantiomer
Talk:Isocitric acid

message: The structural formula :File:Threo-Ds-isocitrate_wpmp.png and hence its vector version :File:isocitric acid.svg seem to be disputed. Verify and suggest the correction. --Rubber Duck (☮ • ✍) 18:41, 25 April 2015 (UTC)
thread_title:  Disputed structure 

message: How many stereocentres ? 1 or 2 ?  Presumably most biological isocitric acid is L- ? - Rod57 (talk) 00:55, 22 January 2017 (UTC)
thread_title:  How many stereoisomers
Talk:Oxalosuccinic acid

message: OxaloIsobutyric acid is more coherent with the usage of the oxalo prefix. E.g. like it is used with oxaloacetic acid. Though this molecule does not seem interesting enough to warrant changing the trivial name. And the use of the oxalo prefix is not well documented.158.132.137.226 (talk) 06:13, 12 June 2014 (UTC)
thread_title:  Succinic acid makes no sense
Talk:Heme O

message: The structure of Heme O on Wikipedia matches with a structure on PubChem  but NOT with the structure on ChemSpider .  However, a search of PubChem by the CAS number on Wikipedia exposes another version of Heme O labeled with the Mesh Annotation . I believe THIS is the correct Heme O, not the one shown but consistent with ChemSpider.--ChemSpiderMan (talk) 21:01, 13 January 2008 (UTC)
thread_title:  Wrong structure?
Talk:Heme C

message: The structure shown is wrong. The two SH groups should not be there in the figure and in the formula. The sulphurs in the thioethers are donated by the cysteines in the protein, as stated in the text. The molecular weight is 618.50. See the HEC definition in the protein data bank, showing the heme before being attached to the cysteines by opening of the double bonds . As I am new here, I don't know how to edit the figure.Marcellus Ubbink (talk) 19:45, 3 October 2014 (UTC)
thread_title:  What is the correct structure? 

message: The graphic shows two sulfhydryl groups on the heme group. It should be more clear that the sulfur atoms belong to the apoprotein: R1-S-Heme-S-R2
Morten Nedertoft
130.226.87.177 (talk) 12:10, 6 February 2009 (UTC)
thread_title:  Confusing graphic
Talk:Heme B

message: Compare the Wikipedia structure with the PubChem structure and notice the difference in MF. Also, what is the best representation for the structure? WP or PubChem? I'd like to know the consensus to reproduce it in ChemSpider since there are THREE representations in CS  .--ChemSpiderMan (talk) 18:24, 13 January 2008 (UTC)
thread_title:  How should the structure be drawn?
Talk:Heme A

message: PubChem has a different structure listed as [heme a http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5489981]
Is the one on Wikipedia the right one? Notice the saturated versus unsaturated chain. I believe the SATURATED chain is [the correct one since it is marked with the MESH Annotation http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5288529 ] but the unsaturated one isn’t. --ChemSpiderMan (talk) 04:34, 13 January 2008 (UTC)
replies: text: I agree with you regarding the length of the chains too. See my report online regarding this compound here: http://www.chemspider.com/docs/wikipedia/Wikpiedia_Review_project_011208.pdf--ChemSpiderMan (talk) 16:58, 13 January 2008 (UTC)
thread_title:  Is this the right structure??
Talk:Carbonyl cyanide m-chlorophenyl hydrazone

message: Why is the abreviation is so patriotic?))))))
: Really. It should be CCCH. --Renessaince (talk) 07:51, 20 October 2011 (UTC)
thread_title:  Ahahaha! 

message: Are they talking about plants?  — Preceding unsigned comment added by 172.77.225.24 (talk) 04:52, 8 October 2017 (UTC)
thread_title:  "seedling mitochondria" ?

message: CCCP is not an inhibitor of OXPHOS, it is an uncoupler. At high concentration it will act as inhibitor.  — Preceding unsigned comment added by 87.231.255.210 (talk) 19:01, 29 January 2019 (UTC)
thread_title:  "Inhibitor vs uncoupler" ?
Talk:Ribose 5-phosphate

message: There are three different CAS numbers assigned:
*4300-28-1 for D-Ribose 5-phosphate
*3615-55-2 for Ribose 5-phosphoric acid and
*93-87-8 for D-Ribofuranose 5-phosphate
--Cvf-ps (talk) 18:29, 13 March 2012 (UTC)
thread_title:  CAS
Talk:Chlorobutanol

message: The rat abuse section is unsourced and unnecessary. The external link describes toxicity in humans and if necessary that should be sufficient, yes? I intend to delete the rat abuse chronicle. ~ R.T.G 15:40, 9 September 2009 (UTC)
thread_title:  Rat abuse section 

message: The odor is very similar to camphor, not to menthol. --FK1954 (talk) 18:29, 7 October 2015 (UTC)
thread_title:  Odor 
Talk:Tert-Butyl chloride

message: Does anyone else think this sentence is too 'wordy'?
"When tert-butyl chloride is dissolved in water, a polar and protic solvent, the bulky chloride substituent is carried away by it, and isolated from the aliphatic chain, causing an heterolitic rupture of the compound, giving rise to a carbocation which eventually becomes a tertiary alcohol after a water molecule reacts with it, releasing hydrochloric acid as the final product."--Bfesser (talk) 00:19, 30 January 2008 (UTC)
thread_title:  Too 'Wordy' 

message: sorry, would fix, im writing a speech, and doing homework  —Preceding unsigned comment added by 82.31.223.231 (talk) 18:18, 24 February 2009 (UTC)
thread_title:  text goes over into table on right
Talk:Morphine-3-glucuronide

message: The figure represents Morphine-6-glucuronide not Morphine-3-glucuronide.
Compare with figure in Morphine-6-glucuronide page.
194.167.77.1 (talk) 13:37, 11 August 2010 (UTC)
replies: text: It seems to be correct now.  ChemNerd (talk) 17:38, 24 April 2012 (UTC)
Talk:4-Nitrophenol

message: I don't know, with 100% certain, how this 4-nitrophenol is produced, but I thisn using nitric acid and phenol, we could produce 4-nitrophenol:
HNO3 + C6H6O(Phenol) ----> C6H5NO2 (4-nitrophenol) + H2O(water) Agre22 (talk) 22:21, 13 July 2008 (UTC)
thread_title: Untitled

message: This compound article now has two SMILES parameters (in the Chembox). Is that OK? 
| SMILES1 = c1cc(ccc1[N+](=O)[O-])O
| SMILES = O=[N+]([O-])c1ccc(O)cc1
:-DePiep (talk) 19:20, 15 October 2020 (UTC)
replies: text: I see: JSmol image shows: they are isomers. -DePiep (talk) 20:44, 15 October 2020 (UTC)
thread_title: Two SMILES
Talk:1,3-Dichloropropene

message: "DCP is testable via blood and urine tests, although it is only detectable in the body for 1-2 after exposure. Exposure level estimates are possible with a blood sample."
What unit of time belongs there?  Days? Weeks?  Hours? Years?  —Preceding unsigned comment added by 71.237.19.71 (talk) 00:52, 1 July 2008 (UTC)
thread_title: Untitled
Talk:Acetoacetyl-CoA

message: — Assignment last updated by Abidur.rafi24 (talk) 01:56, 13 November 2022 (UTC)
thread_title: Wiki Education assignment: CHEM 378 - Biochemistry Lab

message: * Hasegawa, Shinya; Noda, Kazuki; Maeda, Akina; Matsuoka, Masaru; Yamasaki, Masahiro; Fukui, Tetsuya (2012-11-01). "Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels". Molecular Genetics and Metabolism.
    -  This is a research paper focused on Acetoacetyl-CoA synthase and can be used as a reliable source for some simple facts within the wikipedia page that may have originally lacked a source.
* Bissonnette, Bruno; Luginbuehl, Igor; Marciniak, Bruno; Dalens, Bernard J. (2006), "Mitochondrial Acetoacetyl-CoA Thiolase (ACAT) Deficiency", Syndromes: Rapid Recognition and Perioperative Implications, New York, NY: The McGraw-Hill Companies
    -  This is a book published by McGraw Hill, so it should be a reliable source. It also covers the topic in some depth, so it's helpful in establishing notability.
* Aledo, Rosa; Zschocke, Johannes; Pié, Juan; Mir, Cecilia; Fiesel, Sonja; Mayatepek, Ertan; Hoffmann, Georg F.; Casals, Núria; Hegardt, Fausto G. (2001-07-01). "Genetic basis of mitochondrial HMG-CoA synthase deficiency". Human Genetics.
    -  This is a research paper dicussing the genetics basis of 3-hydroxy-3-methylglutaryl-CoA synthase and can be used as a source for facts mentioned within the wikipedia page relating to its autosomal recessive disorder.
* Hasegawa, Shinya; Ikeda, Yotaro; Yamasaki, Masahiro; Fukui, Tetsuya (2012). "The role of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, in 3T3-L1 adipocyte differentiation". Biological & Pharmaceutical Bulletin.
    -  This is a journal article on the role of Acetoacetyl-CoA synthetase and can be sued a s a source of simple facts regarding its function and use of Acetoacetyl-CoA.
* Hasegawa, Shinya; Kume, Hiroki; Iinuma, Sayuri; Yamasaki, Masahiro; Takahashi, Noriko; Fukui, Tetsuya (2012-10-19). "Acetoacetyl-CoA synthetase is essential for normal neuronal development". Biochemical and Biophysical Research Communications. 
    -  This is a journal article that discusses the importance of Acetoacetyl-CoA synthetase in neuronal development, thus can be used as a source for validating facts discussed about Acetoacetyl-CoA and Acetoacetyl-CoA synthetase. 
Abidur.rafi24 (talk) 01:04, 8 December 2022 (UTC)
thread_title:  Bibliography
Talk:Tetraethyl orthosilicate

message: I changed the only external link into a general reference, but after looking at the external link, it still needs more citations, particularly in the applications heading, as there isn't any mention of applications on the referenced page. Kaos-pheory (talk) 09:31, 3 July 2008 (UTC)
thread_title:  References 

message: Is there a process that can use this as a starting material for the production of a sealed quartz (silicon oxide) container (envelope, outer sphere, etc) of some type containing either ethanol or ethanol/water mixture? It seems a good route to a nanotech utopia where little bottles of vodka grow on special trees. 70.162.59.114 (talk) 07:53, 18 December 2008 (UTC)
thread_title:  Processes