Talk:Progeria

message: Hi.
I just wondered if people who suffer from Progeria's hormone cycle is the same as people not suffering from it. For example, do progeria girls' menstrual cycles start prematurely?
Jchillerup 21:17, 13 July 2005 (UTC)
replies: text: Progeria in itself is just premature aging and forms a heterogenic group of diseases which can be inherited in different ways. E.g. classic (Hutchinson-Gilford) progeria is autosomal dominant, later onset (werner syndrome) progeria is autosomal recessive. --WS 23:40, 13 February 2006 (UTC)
replies: text:  Btw. it is more complicated than that, for a discussion of the inheritance of H-G progeria see . --WS 23:57, 13 February 2006 (UTC)

text:  But a link 'Progeria' (perhpas on a disambiguation page if 'progeria' can refer to more than just Hutchinson-Gilford progeria) should be maintained, as 'progeria' is the commonly-used lay-term for the syndrome - Jim Witte —The preceding unsigned comment was added by 216.9.143.221 (talk) 17:41, 24 January 2007 (UTC)
thread_title:  Progeria and hormones 

message: I need some pictures for a visual aid... other then people who have the disease. That is all there is on google images and all the sites I've been to.  —Preceding unsigned comment added by 68.37.51.204 (talk) 03:03, 5 April 2006 (UTC)
replies: text: Can you say where these images come from, if you own the copyright and whether you are willing to release the copyright? --apers0n 12:07, 22 September 2006 (UTC)
replies: text: The Progeria Research Foundation might be willing to grant you permission to use appropriate photographs from their collection for this article or to connect you with family members who might. Likewise, it's possible that they may grant use of their charts or graphics. It can't hurt to ask: http://www.progeriaresearch.org/ Best of luck, Wordreader (talk) 03:44, 14 January 2014 (UTC)
thread_title:  Pictures 

message: I added internal Wiki-links for the terms 'CAAX box' and 'C-termius' under the Cause section.  It seems to me that basic terms like this should be defined somewhere, as should other terms for general DNA structures such as 'forkhead box', 'winged helix' - I assume these are general structures (I am not a geneticist)  The referencing articles do not exist yet. - Jim Witte—The preceding unsigned comment was added by 216.9.143.221 (talk) 17:37, 24 January 2007 (UTC)
thread_title:  References 

message: FYI, I removed the first sentence of the symptoms section - i.e. "Symptoms generally begin appearing around 18-24 months of age.".  Progeria diagnosises have actually occurred within the first 5 months of life and certain symptoms can be witnessed at birth or shortly thereafter (i.e. FTT and a specific skin abnormalities).
Want to modify the list to include other common symptoms (i.e. lack of subcutaneous fat causing prominent veins on the head, atrophy of lower legs etc.)
Yelirmac 03:00, 17 June 2007 (UTC)
thread_title:  Symptoms 

message: "Currently, there are 51 known cases in the world."
"Around 100 cases have been identified since then."
Am I missing something?     --68.100.13.86 18:16, 27 July 2007 (UTC)
replies: text: There are around 50 living "progerians" worldwide -- there have been over 100 diagnoses since the disease was first classified. Yelirmac 21:28, 6 August 2007 (UTC)
thread_title:  Inconsistency: Number of Cases  

message: There's a lot of jargon in the overview section, particular the paragraph that starts with "Prelamin A...".  It's unreadable to the layman.  So I've tagged it in hopes of a cleanup or revision.  (Darthveda (talk) 13:19, 6 February 2008 (UTC)
thread_title:  Jargon 

message: The popular culture section seems to attract trivial entries from popular entertainment.  Furthermore, in almost every case, the 'progeria' is not actually progeria; it's an invented syndrome with remarkably little connection to the real thing.  Could we perhaps turn this into a paragraph about the way that progeria is misrepresented in popular culture?  Does anyone know of any sources that we could use to support it?  WhatamIdoing (talk) 01:42, 14 November 2008 (UTC)
replies: text: I agree with WhatamIdoing. I came to the "Talk" page because the "Popular culture" section looks like a list of greatest hits. Some items actually involve progeria, some are merely speculated to do so. The items aren't even in alphabetical or chronological order. Incorporating the information into a cited paragraph will help winnow the chaff. The member's suggestion about misrepresentation of the disorder in popular culture is a good one as long as sources can be found that do so. Otherwise, there might be the temptation to lapse into original research. Thank you, Wordreader (talk) 02:03, 14 January 2014 (UTC)
thread_title:  Popular culture 

message: I'm not sure where this information might go in the article, but Rabbi Harold Kushner's son, Aaron, died of progeria in 1977 at age 14.  Kushner is the author of the book "When Bad Things Happen to Good People". 98.229.226.9 (talk) 04:36, 2 December 2008 (UTC)
replies: text: From what I can tell the S1E2 is nothing related to progeria but may be put under Accelerated aging disease.  As for someone adding something, if you want something added, best way of getting it done is adding it yourself. Kylin13 (talk) 18:09, 2 February 2011 (UTC)
thread_title:  Popular Culture: requests for inclusion 

message: I'd like some opinions on the changes in this diff. It's correct that there was a Bodyshock program about an Indian family with five children suffering from progeria - see , but there is also at least the family with two children at . There may be a difference in terminology here, perhaps a confusion between Classical Hutchinson-Gilford Progeria and something else called progeria, such as Werner syndrome. I've read Bruce Korf's paper (reference 2 in the article) and it doesn't discuss families with more than one children suffering from progeria.
The latter link gives the number of living people with progeria as being between 35 and 45, and the anon has given the number as precisely 48 without giving a reference or updating the ref given.
It would appear that the anon's edit is insufficiently referenced, but it is not obviously incorrect. Perhaps it has some information previously missing from the article. I reverted it as being contrary to the sources a few days ago, but now that I've looked at it in more detail, I think perhaps our sources are incomplete.-gadfium 00:58, 21 January 2009 (UTC)
replies: text: Well, if there is a WP:RS, we follow that. I would take the NEJM article as authoritative, but you can't access that without a subscription. Nbauman (talk) 03:51, 21 January 2009 (UTC)
replies: text: I think we can afford to take a pretty hard line with the referencing.  If it's not in the listed ref, it shouldn't be in the article.  WhatamIdoing (talk) 00:17, 22 January 2009 (UTC)
thread_title: Inherited progeria

message: The navigation bar (is that what it is called?) at the bottom of the page classifies progeria as an endocrine disorder, but I can't see the link to hormones in what is essentially a genetic nuclear disorder.
Tanjx (talk) 09:12, 28 September 2009 (UTC)
thread_title:  Progeria  under endocrine pathology? 

message: There is also a 'HINDI' movie based on this diesease by the name PAA (meaning 'father' in English). The lead role in the movie is played by legendary star of Hindi Cinema Amitabh Bachchan and his son Abhishek Bachchan. The female lead in the movie is played by Vidya Balan.  —Preceding unsigned comment added by 202.79.203.43 (talk) 07:28, 13 February 2010 (UTC)
replies: text: The article mentions this. See Progeria#Popular culture, second paragraph. The details of the actors is not relevant here.-gadfium 07:48, 13 February 2010 (UTC)
thread_title:  Media/Awareness 

message: The article contains this referenced statement: "Those born with progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties."  Since I don't have access to these articles, can someone double check them?  In particular I am curious about the upper age limit for progeria survival.  According to: http://www.progeriaresearch.org/about_progeria.html  " Children with Progeria die of atherosclerosis (heart disease) at an average age of thirteen years (with a range of about 8 - 21 years).  * Other progeroid syndromes include Werner's syndrome, also known as "adult progeria" which does not have an onset until the late teen years, with a life span into the 40's and 50's."  Since this is in reference to 'other progeroid syndromes' like Werner's syndrome, the reference to people with progreria reaching their forties may be incorrect.  The only reference I was able to find such a thing was the following article which I think most likely spells out that he had a teen-onset progeroid syndrome, not progeria: [I can't post the url here because it triggers a spam filter, but it's an associated content article that I was only able to see by looking up it's cache on google.] Centerone (talk) 01:28, 11 March 2010 (UTC)
thread_title:  Age / Oldest 

message: A progeria is a disease where the patient experiences some characteristics linked to aging quicker than normal. Hutchinson-Gilford should be a separate article because it is an example of a progeria. We should not confuse a progeria with HGS. This article should link to all the possible progerias: Hutchinson-Gilford Syndrome, Werner's Syndrome, and Downs Syndrome.
Cheers  —Preceding unsigned comment added by 70.27.31.100 (talk) 03:17, 12 November 2010 (UTC)
thread_title:  Separate Article for HGS 

message: I encourage editors to watch out for these erroneous labels. Given that 1) the etiology of aging is unknown and 2) progeria does not fully resemble aging, these labels are very misleading despite their prevalent use.--Xris0 (talk) 21:26, 25 January 2011 (UTC)
thread_title: "accelerated aging" and similar labels

message: In the introduction it says: 
:Those born with progeria typically live to their mid teens and early twenties.[4][5] 
:Further down in the article it states  that children with this condition rarely reach 21, 
:There is also a statement referring to early teens. 
OK! let's get it consistent.  It's important. Kids with this condition read Wikipedia, just like all the rest. This is the article that pops up first if you Google.  So what is the expectancy?  Is it "typically" early 20s or "rarely" 21? 
Amandajm (talk) 15:03, 2 November 2011 (UTC)
thread_title: Would someone who has the reference books please get this right.

message: HELP
Hi Kids!
I know maybe it sound ridiculous for all of you that are so clever and so informed about this awful disease, but I am consern about a BIG STUPID ARGUMENT in another knowledge area that maybe can be resolve with clarifying what is Progeria. Let me ask, What do you know about the starchild skull and, can it be a progerian kid skull, as the picture i upload on my website, shows? I want to clarify that is most possible to find a progerian kid skull than an et hibrid skull. Thanks a lot for your really awesome research. (http:tienesmiedoapensar.blogspot.com)  — Preceding unsigned comment added by C (talk • contribs) 06:28, 9 December 2011 (UTC)
replies: text: You might be better addressing this question to the science reference desk. It is not appropriate to talk about supposed alien skulls in the talk page of a medical article.-gadfium 07:48, 9 December 2011 (UTC)

text: the Starchild skull is a very disputed article however and I think Jean wishes for someone more knowledgeable on the topic to provide their insight onto the topic as the "owner" of the topic won't see to reason.  — Preceding unsigned comment added by Judicier (talk • contribs) 02:26, 26 November 2012 (UTC)
thread_title: Starchild skull

message: See http://www.progeriaresearch.org/first-ever-progeria-treatment.html
I appreciate that I could make the changes to the article, but I think it better done by someone with a far greater medical knowledge than myself, or at least by someone more familiar with this article. Consider this a head's up.  fredgandt 21:41, 24 September 2012 (UTC)
thread_title:  A two and a half year study has found an effective treatment 

message: The table at the begining of the "Cause" section states that in a normal cell "Prelamin A is not anchored to the nuclear rim", while in a cell affected by progeria "Progerin is anchored to the nuclear rim". 
At the same time the text that follows the table states exactly the opposite: in a normal cell "...permanently affixes the protein (prelamin A) to the nuclear rim...", while in the affected cell "...abnormal protein, referred to as progerin, cannot be affixed to the nuclear rim..." — Preceding unsigned comment added by Calligrapher (talk • contribs) 17:06, 25 September 2012 (UTC)
thread_title:  Self-contradictory: Cause 

message: The captions, which have already been marked as being too long, are copied wholesale from . This is a clearly copyright violation. I've removed the large image which seems to be based entirely on this research and which will need a new caption, if it is added back to the article. I've trimmed the captions on the other two images. -- Hazhk Talk to me 20:10, 25 November 2012 (UTC)
thread_title:  Copyvio in captions 

message: I have not found "nuclear rim" defined anywhere in Wikipedia. I found a definition at the following website which describes multiple sclerosis.
<http://www.biologyreference.com/Mo-Nu/Nuclear-Transport.html>
A nuclear rim is not the rim of the nucleus, but the inner (nuclear) end of a nuclear pore. I do not know whether it is structurally or compositionally different from the rest of the pore.
The article states that "The farnesyl group allows prelamin A to attach temporarily to the nuclear rim". I have severe doubts about this, but i do not know the relevant literature well enough to adequately research it. It is obvious that a good source needs to be cited.
I suspect that the writer mistook the inside of the nuclear envelope for the nuclear rim. It is also possible that the writer confused the nuclear lamina with the nuclear basket. The latter is attached to the nuclear rim. 76.93.209.228 (talk) 23:39, 26 December 2015 (UTC)
thread_title:  Nuclear rim 

message: So I was reading about an "immortal jellyfish" after I read about progeria, and I was just thinking that for a cure they could just use special hormones or something from the Turritopsis nutricula (the immortal jellyfish). It would kind of make sense in a way… Byu cougs (talk) 05:13, 7 April 2017 (UTC)
replies: text: Jellyfish are very different from humans. Even mouse models very often don't translate well to humans.-gadfium 05:42, 7 April 2017 (UTC)
thread_title:  Cures  

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thread_title:  External links modified 

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thread_title: Copyright cleanup

message: Hello
I was a bit surprised by the sentence "Progeria, also known as "Benjamin Button Disease", and wonder if Progeria is truly refered to as such or of it might be the editor's personal opinion?
After all, the character Benjamin Button was born looking aged but then became younger and younger looking, not older looking, which on the other hand individuals with Progeria do.
Honestly, the only time I had hitherto seen that term (Benjamin Button) is in regards of individuals that appear to not age. For instance the following, who is described as "The Benjamin Button of Korea"; https://www.koreaboo.com/stories/30-year-old-korean-man-rare-condition-makes-look-like-child/
Or this case, where a skincare company is named Benton Inc.; a contraction of Brad Pitt's character Benjamin Button, who the founder described as "a man who ages in reverse", which, as we know, is true about his character.
So, is there truly any support for the claim in question, that Progeria is also known as Benjamin Button Disease?
Thank you. Okama-San (talk) 16:59, 10 September 2019 (UTC)
replies: text: moved to popular culture section. --Akrasia25 (talk) 20:54, 10 November 2020 (UTC)
thread_title:  Benjamin Button? 

message: I believe the YouTuber Justin Tsimbidis (used to be Tsimfuckis) has progeria as well.  He is currently 28 years old. Doris Mae1997 (talk) 04:27, 3 October 2021 (UTC)
thread_title:  Pop culture -- Justin Tsimbidis 

message: The lede says "Patients born with progeria typically live to an age of mid-teens to early twenties" but under Prognosis it says "few people with progeria exceed 13 years of age", and this is in the summary box at the top as well. This doesn't seem consistent.
It also says "Progeroid syndromes are a group of diseases that causes individuals to age faster than usual", but the page on Progeroid syndromes says that they mimic physiological aging, which doesn't seem like quite the same thing.
Can someone comment on this? I have no subject knowledge here. RapturousRatling (talk) 20:13, 28 January 2022 (UTC)
thread_title:  Lede questions