Talk:Thrombophilia

message: http://bloodjournal.hematologylibrary.org/cgi/content/full/112/1/19 JFW | T@lk 21:00, 10 July 2008 (UTC)
thread_title:  History 

message: Uncomplicated VTE is no indication for thrombophilia testing. In the MEGA study, those who were tested were no less likely to have a recurrence: . JFW | T@lk 19:56, 26 August 2008 (UTC)
replies: text: PMID is wrong, but it was a primary study anyway. JFW | T@lk 00:20, 21 February 2011 (UTC)
thread_title:  No point 

message: I took a clue from , who on the assessment page suggested that the list of causes probably had too many bullet points. I have started to prosaify the content, basing myself on the current references and adding a load more.
This has prompted the realisation that we are probably not discussing the specific acquired scenarios in sufficient detail. For instance, antiphospholid syndrome is (according to the Lancet review) regarded as a strong indication for long-term anticoagulation. I also need to append the relevant epidemiological data to the "epidemiology" section. JFW | T@lk 10:10, 25 February 2011 (UTC)
thread_title:  Causes 

message: doi:10.1111/j.1538-7836.2009.03394.x is a review from two Dutch kings of genetic thrombophilia (Rosendaal and Reitsma). It is fairly short but discusses the utility of genome-wide association studies and the fact that most genetic thrombophilias confer at most a moderate risk of VTE. JFW | T@lk 12:52, 27 February 2011 (UTC)
thread_title:  More genetics! 

message: Kumar4 is used as a source to support the claim that cigarette smoking is linked with venous thromboembolism. It turns out that it very difficult to find a good corrobative secondary source for this claim. doi:10.1002/ajh.21059 is a primary research study, which in turn cites  (Nurses' Health Study, 1997). The topic has not been reviewed independently from OCP use. I am removing it until we can support this with better sources, and I remain open to suggestions. JFW | T@lk 14:18, 27 February 2011 (UTC)
thread_title:  Smoking 

message: This is little question that obesity, apart from by mechanical reasons, also has its associated thrombophilia; this is presumed to be due to PAI-1 hypersecretion by fat cells.  is a review on the topic, but I can't access it currently. It should probably be included. JFW | T@lk 14:25, 27 February 2011 (UTC)
thread_title:  Obesity 

message: Unrelated to GA review:  Do you think that :File:Warfarintablets5-3-1.jpg (shown) might be a better choice for the likely audience than a chemical diagram?  I believe it's famous for its color coding (which seems to vary by country). WhatamIdoing (talk) 18:54, 19 March 2011 (UTC)
replies: text: I have no objection. JFW | T@lk 00:11, 20 March 2011 (UTC)
thread_title:  Image 

message: Isn't malignancy one of the major causes of hypercoagulable states (and yes, I too see this term used much more than thrombophilia, but I digress...)? If so, I don't see much discussion of it.  Am I missing something? Yobol (talk) 04:20, 30 March 2011 (UTC)
replies: text: Some sources don't classify malignancy as a "thrombophilia" sensu strictu, possibly because cancer leads to thrombosis by other mechanisms rather than just rheological ones. For instance, large-volume retroperitoneal deposits cause flow abnormalities in the inferior vena cava and increase thrombosis risk by that mechanism. I see no problem mentioning malignancy, but it would need to have a suitable source. Heit mentions "active cancer" in his list, and so does Rosendaal2005. I will therefore add a few lines. JFW | T@lk 04:25, 30 March 2011 (UTC)
thread_title:  Malignancy 

message: In regards to prothrombin G20210A I was skeptical that the promoter region was the right way to describe it, so I made this edit because that is what was verified, but I was reverted. So I looked up this and this. It's clear the 20210 refers to the position on the sense strand, where position 1 to 3 is ATG for the start codon. 20210 occurs in the 14th and last exon, but in the 3' untranslated region after the 14th exon is done coding. 20210 is also next to/near where the poly-A tail is attached on the pre-mRNA. This can't be part of the promoter region, as far as my knowledge is concerned. It was mentioned in the discussion of the 1996 publication that the polymorphism could contribute to RNA stability/translation efficiency. Biosthmors (talk) 19:58, 1 February 2012 (UTC)
replies: text: I reverted the change only because 3' untranslated region redirects to Three prime untranslated region, and I hadn't given your distinction between 3'UTR and promotor a second thought. My apologies for missing that. I will make the required correction. JFW | T@lk 20:45, 1 February 2012 (UTC)
replies: text: Ah. No problem. My apologies for not using a more detailed edit summary. And I put the research to good use over at the other article. Thanks. Biosthmors (talk) 16:35, 3 February 2012 (UTC)
thread_title:  Promoter region? 

message: Although this article contains reasonable number of references, the reference below can be cited and resources can still be drawn from:
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DiptanshuTalk 08:24, 27 May 2013 (UTC)
replies: text: I don't see how either of these sources would add anything to the current content. The first simply discusses everything we already cover and is from a low-impact journal in Eastern Europe. The second is 27 years old and would qualify as "historical interest" only. JFW | T@lk 17:33, 27 May 2013 (UTC)
thread_title:  Resources 

message: Review by Heit doi:10.1161/CIRCULATIONAHA.113.001943 JFW | T@lk 21:15, 14 January 2014 (UTC)
replies: text: doi:10.1161/CIRCULATIONAHA.113.007664 - further review by Piazza. JFW | T@lk 19:09, 20 July 2014 (UTC)
thread_title:  Circulation 

message: doi: 10.1056/NEJMra1700365 JFW | T@lk 11:41, 24 September 2017 (UTC)
thread_title:  NEJM 

message: CD seems to be a significant risk factor, see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616811/ --2A02:560:4147:A600:D14C:5C05:3258:AA20 (talk) 10:58, 23 March 2019 (UTC)
thread_title:  Celiac Disease