Talk:RNA polymerase II

message: I am confused by the elongation part of this article and I see no citations or references that would allow the text to be verifiable.
*Did you read the recent review by one of the experts on transcription regulation: Danny Reinberg? I think this would help the entire article a lot, especially the elongation part could be revised thoroughly.
*I don't understand the classification of elongation promoters?? Even if these are rather factors I don't follow it. Why did you make this division? What means Drug/sequence-dependent arrest affected factors? Why would factors that are affected by drugs be different from the ones that affect the catalytic activity of the RNA polymerase? 
*What is the reference of There is, however, a change in methylation of the polymerase, midway through elongation the phosphorylation location changes slightly under the influence of Ctk1.? What is meant by the phosphorylation location? Do you mean a site on the CTD of the polymerase? --AAM 22:19, 19 February 2006 (UTC)
thread_title:  Confused by the elongation part

message: This article tells me what RNA polymerase II does, but it doesn't say what it is - is it a kind of RNA? An organic chemical? An organelle? Same complaint for RNA polymerase I and RNA polymerase III. This is like writing an article on horse saying that a horse is ridden and used for farm work without ever saying that it is an animal! bd2412 T 18:28, 15 December 2006 (UTC)
replies: text: Please note: hnRNA = heterogeneous nuclear RNA (the unspliced pre-mRNA is of very different size, only found in the nucleus, hence its name; see Alberts et al.) and likewise hnRNP = heterogenous nuclear ribonuclein protein (a protein associated with hnRNA). Wlanger (talk) 10:50, 16 January 2011 (UTC)
thread_title:  So... what ''is'' it? 

message: I think this article would benefit from a picture/diagram of RNAP II. 203.160.122.99 21:26, 19 October 2007 (UTC)
replies: text: We might try "RNA polymerase (1i6h).png" from Wikimedia Commons.  I can look into it further, but I think it's an image of yeast RNA polymerase II.    Forluvoft 21:37, 19 October 2007 (UTC)
thread_title:  Picture? 

message: Shouldn't this article and others related to transcription be re-categorized to a new category, :Category:DNA transcription?  :Category:DNA replication doesn't make sense to me.  —Preceding unsigned comment added by Skoch3 (talk • contribs) 05:59, 11 January 2008 (UTC)
thread_title:  New category to replace DNA Replication category? 

message: I find this article a bit confusing. RNA polymerase II is only a small part of it. Transcription of primarily mRNAs occurs after the RNA polymerase II holoenzyme has been assembled and in place on the promoters. May I suggest replacing the transcription sections with a short discussion of RNA polymerase II holoenzyme, and let the holoenzyme article begin the discussion of transcription.
Also, what do you think of additional sections here about transcription of the subunits of RNAP2? What causes its transcription? How many are made and incorporated into transcription factories?
And, perhaps a bit more on the assembly of RNAP2 would be good: parallel processing, concentration dependency, diffusion, or active diffusion?
How long do the components (subunits) last before the cell has to replace each. How is this done? Is the whole complex destroyed or is there part replacement? Marshallsumter (talk) 00:26, 14 February 2010 (UTC)
thread_title: Possible revision of article

message: I am going to add a history/discovery section: One that talks about the discovery of the enzyme RNA Polymerase II. In this same section I will quickly summarize the other two RNA Polymerases (I,III) and possibly how to distinguish between them experimentally. This addition, not sure in the same section, I will emphasize that the three different polymerases play different roles in transcription. (All the enzymes will be linked to their corresponding wiki page).
In the introduction: I am going to add the specific promoter the enzyme binds to (Class II Promoter), and a brief description of what that is. Also in the introduction I am going to mention the role it plays with other proteins to form the "pre-initiation complex" and what this is in terms of transcription.
Jasper94574 (talk) 06:27, 21 February 2017 (UTC)
thread_title:  Additions to page 

message: The section begins with a general paragraph about how RNA polymerase II is an enzyme and how they are like, but not the values of its K_m, k_\text{cat} or V_\text{max}. Alfa-ketosav (talk) 07:20, 21 April 2024 (UTC)
thread_title:  Kinetics