Talk:Opiate

message: Actually, the broadest term is "opioid", which is any substance, natural or synthetic, that behaves like morphine in the body. The term "opiate" is generally understood to mean only those opioids that occur naturally, or are derived from them. Examples of opioids that would not be opiates are the synthetics fentanyl and methadone.
This would be a fairly major revision, so what do others think about making it?
--Phil Karn
:Go for it. Only opioids in my opinion are really a class of chemical compounds that show affinity to opioid receptors. Kpjas
I know that opiates are much more readily available from the seed pod and other parts of the straw than they are from the seed.  I would recommend changing the text to reflect this by replacing "seed" with "seed-pod" in the article. -- Morelos
jejje
::Opiate is a drug which comes from opium or poppy straw. Opioid is a drug which acts on the opioid receptor (mu, kappa, etc.).  Most opiates are opioids, but not all (Papaverine, for example is an opiate with no opioid effects).  The two terms mean different and non-overlapping things.  They get confused and confounded all the time, and I am changing the introduction sentence to clarify that.  -- Kevin  — Preceding unsigned comment added by DrKC MD (talk • contribs) 23:26, 11 November 2023 (UTC)
replies: text: Papaverine on the page.  W;ChangingUsername (talk) 19:31, 1 June 2024 (UTC)
thread_title: Untitled

message: While thebaine is indeed a minor component of opium, this compound is not primarily obtained from opium but from 
P. bracteatum or more recently from special cultivars of P. somniferum for legal extraction directly from plant biomass. I needed to clarify this, since thebaine does not participate in the narcotic effect of opium, and is not a main constituent thereof. Since, these are potent pharmacological agents under international control, correct statements are imperative to avoid confusion and misinterpretations.  — Preceding unsigned comment added by Osterluzei (talk • contribs) 02:03, 13 February 2011 (UTC)
thread_title: Clarification with regard to thebaine

message: Thebaine is one of the alkaloids present in opium.  The relative amount, or usual commercial source, is irrelevant.  It is, has been, and always be an opiate.  — Preceding unsigned comment added by 75.73.1.89 (talk) 06:18, 23 April 2013 (UTC)
thread_title: Clairification

message: This article was tagged for copy-paste concerns. Evaluation shows that content entered in May 2007 duplicates content from poppies.org which is, unfortunately, not compatibly licensed with Wikipedia (see their terms of service). Other content added by this contributor may need to be checked for copying. Any assistance in rewriting the article to remove this material by interested editors would be much appreciated, since otherwise it may simply need to be excised. --Moonriddengirl (talk) 00:42, 11 March 2012 (UTC)
thread_title: Copyright problems

message: This article is in sorry shape.  The article does not even mention the cardinal effects of opiates (euphoria, analgesia, sedation, resp. depression etc.); the bulk of the content is contained in the section about individual alkaloids and is often not even relevant, eg. the first thing noted about morphine is that it does not cause pulmonary edema as often as heroin.  This is true but hardly the first thing worth noting abour morphine ("Morphine is the principle active in opium, and is the gold standard by which all other narcotics are measured" would be a good one, etc.).
This is a fairly important article given the crucial importance of opiates in medicine; by comparison, look at Morphine! That article arguably has more information about opiates in general in it than this article does itself!  IforgotAboutSemiProtection (talk) 00:48, 30 June 2012 (UTC)
replies: text: Opioid is pretty thorough. Maybe that's what you're looking for?CrocodilesAreForWimps (talk) 04:37, 13 February 2013 (UTC)
thread_title:  Article could use a major overhaul 

message: It appears that you folks are aware of the conflicting definitions of opioid here and in the opioid article. Here opioids include opiates; there opioids are exclusive of opiates. Here morphine is an opioid; there morphine isn't an opioid. Both definitions exist as do editors' opinions. Neither definition is wrong. However Wikipedia needs to settle on a consistent definition. I learned the inclusive definition but the exclusive definition might reduce ambiguity. Nonetheless I believe the most common accepted use needs to be considered.
I sense the editors here and there may be as different as the definitions. This central issue needs to be discussed and here and at the opioid article talk page and resolved by a common consensus. To use a bad pun, you need to get on the same page. Box73 (talk) 11:26, 4 October 2015 (UTC)
replies: text: I address this under the Heroin section of this Talk page. I think it worthwhile to repeat CITE YOUR SOURCES! Right here on the Talk page. The common accepted use isn't really an issue to discuss at this point, because editors are bickering over these definitions with no references here. If we have conflicting definitions that are cited, we can then debate which source is more authoritative. And this doesn't include arguing that one definition is more "scientific". That's a moot point if you don't have a citation. Cuvtixo (talk) 15:08, 1 April 2017 (UTC)

text: Winnner! Just found a good one on the Opioid page. Hemmings, Hugh C.; Egan, Talmage D. (2013). Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application: Expert Consult - Online and Print. Elsevier Health Sciences. p. 253. . "Opiate is the older term classically used in pharmacology to mean a drug derived from opium. Opioid, a more modern term, is used to designate all substances, both natural and synthetic, that bind to opioid receptors (including antagonists). 
Okay, I looked at the Opioid page and judged it to be more authoritative, and newer, citing scientific publications rather than just a definition from an online dictionary. As well changing the introduction I find the former definition differentiating passage here confusing as well as too lecturing or chastising in tone. Note a big problem there, although a scientific book is cited, is that it extensively defines "opioid", when this article is about "opiates", which are simply a subset of opioids, as admitted to in the passage. Several not-opiate opioids are mentioned and linked to articles. Such definitions should be moved to Opioid, rather than reverting here, or included in a new article about Synthetic and/or Semisynthetic Opioids. If it simply defined opiates further there would be no issue.
Cuvtixo (talk) 15:54, 1 April 2017 (UTC)
thread_title:  As above... Conflicting definitions of opioid. 

message: ===Proposed edits===
*I think this article also needs to incorporate more of the history of opiates in its introduction before it starts talking about opiate abuse. Something like "Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD."  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46725/pdf/pnas01469-0022.pdf
*I believe it would be a good idea to briefly touch on what receptors opiates act on and how that relates to the physiological effects. I would add a physiological effect section after the esters of morphine section, including the main opioid receptors: mu (μ), delta (δ), Kappa (κ) and NOP. Mu is involved in the pain and analgesia pathways that opiates are used for and associated with. Other clinically important roles of mu are its involvement in respiratory and cardiovascular functions, gastrointestinal peristalsis, feeding, and mood. I don't think that too much further information is needed as long as we would like to link these to their respective Wikipedia pages.
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=50
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799236/
*It would be helpful to cover opiates and their medical uses today, and its potential for dependence and abuse. I would like to add a section for Opiate Use and Abuse with some statistics such as "In 2016, the World Health Organization reported that 27 million people suffer from opioid abuse disorder. WHO also reported that in 2015, 450,000 people died as a result of drug use, with between a third and a half attributed to opioids." https://www.who.int/substance_abuse/information-sheet/en/
RessoC (talk) 20:03, 16 October 2019 (UTC)
thread_title: CP133 2019 Group 12 proposed edits

message: *I think this article also needs to incorporate more of the history of opiates in its introduction before it starts talking about opiate abuse. Something like "Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD."  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46725/pdf/pnas01469-0022.pdf
*I believe it would be a good idea to briefly touch on what receptors opiates act on and how that relates to the physiological effects. I would add a physiological effect section after the esters of morphine section, including the main opioid receptors: mu (μ), delta (δ), Kappa (κ) and NOP. Mu is involved in the pain and analgesia pathways that opiates are used for and associated with. Other clinically important roles of mu are its involvement in respiratory and cardiovascular functions, gastrointestinal peristalsis, feeding, and mood. I don't think that too much further information is needed as long as we would like to link these to their respective Wikipedia pages.
https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=50
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799236/
*It would be helpful to cover opiates and their medical uses today, and its potential for dependence and abuse. I would like to add a section for Opiate Use and Abuse with some statistics such as "In 2016, the World Health Organization reported that 27 million people suffer from opioid abuse disorder. WHO also reported that in 2015, 450,000 people died as a result of drug use, with between a third and a half attributed to opioids." https://www.who.int/substance_abuse/information-sheet/en/
RessoC (talk) 20:03, 16 October 2019 (UTC)
thread_title: Proposed edits

message: Part 1
* I thought Group 12 did a great job in adding more historical context to opiates stating how long they have been around and their role in pain relief. I think this provides a brief background before diving into the abuse potential of the drug. I also think it was valuable that the group members added a section covering the mechanism of action. I think this is vital to understanding the potential for opioid abuse and current epidemic. Adding the pharmacology information also further explains why side effects of opiates occur and how it may lead to respiratory depression and significant deaths. Julie.dao (talk) 21:42, 6 November 2019 (UTC)
thread_title: Peer Reviews