Talk:BDORT/Mediation/CorainderStudy

message: Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice. 
J Ethnopharmacol 2001 Oct;77(2-3):203-8 (ISSN: 0378-8741) 
Aga M; Iwaki K; Ueda Y; Ushio S; Masaki N; Fukuda S; Kimoto T; Ikeda M; Kurimoto M 
Hayashibara Biochemical Laboratories, Inc., Fujisaki Institute, 675-1 Fujisaki, Okayama 702-8006, Japan. 
The preventive effect of Coriandrum sativum, Fam. UMBELLIFERAE (Chinese parsley) on lead deposition was investigated in male ICR mice given lead (1000 ppm) as lead acetate trihydrate in drinking water for 32 days. Administration of Chinese parsley to mice by gastric intubation was performed for 25 days from day 7 after the start of lead exposure up to the end of the experiment. The mice were then sacrificed for comparison of lead distribution. The lead reached its highest concentration in the femur but localized lead deposition in the femur was significantly decreased by meso-2,3-dimercaptosuccinic acid (DMSA), a chelating agent used as a positive control to validate this experimental model. Administration of Chinese parsley also significantly decreased lead deposition in the femur and severe lead-induced injury in the kidneys. In addition, urinary excretion of delta-aminolevulinic acid (ALA) which is known to increase with lead intake was significantly decreased after administration of Chinese parsley. The MeOH extract of Chinese parsley also reduced lead-induced inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity in vitro. These results suggest that Chinese parsley has suppressive activity on lead deposition, probably resulting from the chelation of lead by some substances contained in Chinese parsley. 
Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC Numbers 
Coriandrum
Kidney Tubules, Proximal [drug effects]
Lead Poisoning [prevention & control]
Lead [pharmacokinetics]
Phytotherapy
Plant Extracts [therapeutic use]
Kidney Tubules, Proximal [pathology]
Mice, Inbred ICR
Mice
Porphobilinogen Synthase [metabolism]
Tissue Distribution
0 (Plant Extracts)
7439-92-1 (Lead)
EC 4.2.1.24 (Porphobilinogen Synthase)
Indexing Check Tags: Animal; Male 
Language: English 
MEDLINE Indexing Date: 200112 
Publication Type: Status: Completed 
Publication Type: Journal Article Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils [In Process Citation] 
Int J Food Microbiol 2002 Mar 25;74(1-2):101-9 (ISSN: 0168-1605) 
Delaquis PJ; Stanich K; Girard B; Mazza G 
Agriculture and Agri-Food Canada, Pacific Agri-Food Research Centre, Summerland, British Columbia. delaquisp@em.agr.ca. 
Essential oils from dill (Anethum graveolens L.), coriander (seeds of Coriandrum sativum L.), cilantro (leaves of immature C. sativum L.) and eucalyptus (Eucalyptus dives) were separated into heterogeneous mixtures of components by fractional distillation and were analyzed by gas chromatography-mass spectroscopy. Minimum inhibitory concentrations against gram-positive bacteria, gram-negative bacteria and Saccharomyces cerevisiae were determined for the crude oils and their fractions. Essential oil of cilantro was particularly effective against Listeria monocytogenes, likely due to the presence of long chain (C6-C10) alcohols and aldehydes. The strength and spectrum of inhibition for the fractions often exceeded those determined in the crude oils. Mixing of fractions resulted in additive, synergistic or antagonistic effects against individual test microorganisms. 
Language: English 
MEDLINE Indexing Date: 200204 
Publication Type: Status: In-Process 
Publication Type: Journal Article 
PreMedline Identifier: 0011929164 
Unique NLM Identifier: 21926088 
Journal Code: IM 
PreMedline Identifier: 0011535365 
Unique NLM Identifier: 21427012 
Journal Code: IM 
Richardmalter 09:16, 21 August 2006 (UTC)
replies: text: Please excuse my ignorance, but this seems to me to be a paper describing how Chinese parsley was used in mice to apparently reduce toxic effects of lead poisoning or some micro-organisms. I don't see where it mentions BDORT or Omura and how it is relevant to our Omura/BDORT article. Crum375 11:28, 21 August 2006 (UTC)