Talk:Automated insulin delivery system

message: The following list of research companies studing micro-encalsulation of islet cells was removed from the article as it may encourage link-spamming.  I'm temporarily pasting it back in here so that those sources can be reviewed and pertinant data included in the article.
====Bio-tech companies working on incapsulated islets and islet sheet technology====   
*Novocell, Inc. 
  
*AmCyte, 
   
*Living Cell Technology,
    
*MicroIslet Inc.,   
 
*Islet Technology, Inc.. 
    mbbradford 21:02, 29 December 2006 (UTC)
thread_title:  List of biotech companies 

message: *Novocell, Inc. 
  
*AmCyte, 
   
*Living Cell Technology,
    
*MicroIslet Inc.,   
 
*Islet Technology, Inc.. 
    mbbradford 21:02, 29 December 2006 (UTC)
thread_title: Bio-tech companies working on incapsulated islets and islet sheet technology

message: It is understandable why there is confusion regarding feedback being positive or negative in the last three sentences of the first paragraph of section "Background in endocrine physiology" since two of the three sentences refers to a negative feedback system while the third refers to a positive feedback system.
The sentence, "Glucagon causes the liver to release stored glucose back into the bloodstream" refers to a positive feedback system. The more glucagon, the more glucose released (not regulated between two boundaries).
The sentence, "Notice that increased glucagon will increase blood glucose levels in a positive feedback loop" (now changed) could possibly refer to its previous sentence with respect to feedback-type, but that would be out of context. This sentence must be referring to a glucose regulated system in the blood (a negative feedback system), and not referring to the glucagon/glucose/liver system which is a positive feedback system.
The last sentence, "Together, the three endocrine hormones work as a system to control the blood glucose level between high and low boundaries" (now changed) clearly refers to a negative feedback system since the words imply regulation between boundaries.
The confusion is due to a "reference" signal mix up in control theory: if glucagon causes glucose to be released from the liver and into the bloodstream thereby raising the glucose level in the blood, this action causes a positive error with respect to the reference signal (i.e. feedback signal > reference signal) in a negative feed back system thereby causing a regulation action with the release of insulin from the pancreas to decrease the positive error and lower the glucose level in the blood. In this regulatory negative feedback system, there are two reference signals, an upper maximum glucose level and a lower minimum glucose level which makes the system more complex. Henry Delforn (talk) 18:18, 30 July 2009 (UTC)
thread_title:  Feedback clarified 

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thread_title:  External links modified 

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thread_title:  External links modified 

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thread_title:  External links modified 

message: Is the gene therapy approach listed here actually considered to be an artificial pancreas? Certainly it's a proposed solution for type I diabetes, but I think it might not fit in this topic. Natureium (talk) 05:28, 21 December 2017 (UTC)
thread_title:  Gene therapy 

message: doi:10.1210/er.2018-00174 JFW | T@lk 13:55, 10 December 2019 (UTC)
thread_title:  Review 

message: Given that the term "Artificial Pancreas" (which is a marketing term only used in the medical literature to acknowledge its colloquial use) refers to a number of biomedical technologies, but most commonly to Hybrid Closed Loop (HCL) and Advanced HCL insulin delivery systems, I propose that "Artificial Pancreas" redirect to/be renamed to a new page specific to Automated insulin delivery systems, with an associated Artificial pancreas (disambiguation) page, that contains links to separate pages for the various technologies that may be referenced by the term.
Gwsuperfan (talk) 19:03, 27 August 2020 (UTC)
thread_title:  Make Disambiguation?