Talk:Cytotoxic T cell

message: I would like to know about the history of a cytotoxic T cell.  I can't find anything on the web!== CD8+ T cells ==
If I remember correctly, CD8+ T cells equals cytotoxic T cells. The article is not clear on this point. / Habj 16:34, 21 December 2005 (UTC)
replies: text: Yes, that is usually correct. I either have, or will make that association. The only problem is (and this is particularly true for CD4+ T cells) that there SOME exceptions to the rule, and this is where service as a general public encyclopedia versus a scientific review comes in. For example, cytotoxic CD4+ T cells do exist, but the incidence of these cells are very rare unless you enter certain disease states. I'm not particularly happy with how this immune page is written; whether that particular page is the best place to place TcR recombination (rather than a dedicated page, since it's a common step for all T cells), and information on how CD8+ T cells actually activate (versus what they do after they activate) is very lacking. The page is also not un-educated person friendly at all. There is no importance mentioned in how helper T cells are essential for their initial activation, or some of the safeguards the immune system has to prevent auto-immunity of cytotoxic T cells (e.g. co-stimulation is absolutely ESSENTIAL aspect in these cells). I could go on. This page was similar to the helper T cell page prior to me almost re-writing the entire page (there are a couple of original fragments, but you'd be lucky to find any more than one). I don't have the energy atm to re-write this page, I'd prefer to reference the helper page before I get stuck into the other immune cell pages.Volantares 12:35, 13 May 2006 (UTC)
thread_title:  History of a cytotoxic T cell 

message: The mention of pathogenesis in various disease states is a good idea, although I feel that perhaps the pathogenesis section just needs a good introduction into the generalised role of cytotoxic T cells (i.e. they kill infected cells, but they have also been implicated in the pathogenesis of various illnesses). Is the discussion of the role of platelets in a Hepatitis B infection beginning to deviate from the purpose of this article? Wouldn't that specific result (especially since it isn't in a review) should remain in the pathogenesis section of Hepatitis B? Volantares 10:49, 6 July 2006 (UTC)
replies: text: I think we're having this problem now between T cell and T helper cell as well.  It may be necessary to coordinate editors for all three pages to come to relevant territorial consensus -- seeing as how it's mostly the same few people. <wink> Jbarin 08:13, 8 May 2007 (UTC)
thread_title:  Discussion of Pathogenesis 

message: I think it is worth noting that this cell (particularly CD8 T Cells) are important in the small, very rare, population of people who have HIV but are immune (or at least very highly protected from) AIDS. —The preceding unsigned comment was added by 68.205.70.254 (talk) 05:15, 29 March 2007 (UTC)
thread_title:  AIDS Immunity 

message: This paragraph only talks about the Instructive Model Pathway for T cell development.
There is another pathway, the Stochastic Pathway, which needs to be added and a statement that there is no general consensus over which one is correct, although most university teach the Instructive pathway. Scubafish 10:48, 29 May 2007 (UTC)
thread_title:  Cytotoxic T cell development 

message: I want to know what is the relationship between Killer T cells and the thymus.  — Preceding unsigned comment added by 96.252.155.69 (talk) 18:07, 6 May 2012 (UTC)
replies: text: That's explained in http://en.wikipedia.org/wiki/Cytotoxic_T_cell#Development but I can understand how that might be unclear to the general reader. I was working on it, and I'll try to make it clearer. --Nbauman (talk) 14:34, 29 June 2012 (UTC)
thread_title:  Killer T cells and the thymus 

message: bruh, the cells r epic  — Preceding unsigned comment added by 76.24.214.142 (talk) 14:56, 28 January 2021 (UTC)
thread_title:  bruh cells 

message: The second paragraph of the activation section currently says:
"The threshold for activation of these cells is very high, and the process can occur via two pathways: thymus-independent (by infected APCs) or thymodependent (by CD4+ T cells). In the thymus-dependent pathway, because the APC is infected, it is highly activated and expresses a large number of co-receptors for coactivation. If APCs are not infected, CD4 cells need to be involved…"
In the second sentence, shouldn’t it say "thymus-independent" instead of "thymus-dependent"? It continues to say “because the APC is infected” and in the first sentence of the paragraph it says "thymus-independent (by infected APCs)". Also, in the third sentence it continues by saying “If APCs are not infected, CD4 cells need to be involved”, implying this is the alternate thymus-independent pathway even though the first sentence says “thymodependent (by CD4+ T cells)”. A bit confusing if you ask me.  — Preceding unsigned comment added by CarlosArceDeza (talk • contribs) 16:36, 26 April 2022 (UTC)
thread_title:  Activation Section Discrepancy