Talk:Naproxen

message: The article states:
"Naproxen should not be taken with antidepressants... Naproxen is not contraindicated in the presence of SSRIs, though concomitant use of the medications should be done with caution".
"not contraindicated seems to contradict the other two statements. I'm not a medical professional, but all the definitions of "contraindicated" I dug up, including from the U.S. National Library of Medicine, include either the meaning "use with caution" or "should not use". So, either the article wording needs to be corrected (perhaps distinguishing between relative and absolute contraindication), or the text should reflect disagreement between two sources.  — Preceding unsigned comment added by Atkinson 291 (talk • contribs) 21:47, 15 February 2018 (UTC)
replies: text: You are absolutely correct! The presence of a drug interaction often isn't a contraindication (a situation in which one should not use a medication; the opposite of an indication), though it sometimes can be. I have corrected the text to represent the source.―Biochemistry🙴❤ 00:37, 16 February 2018 (UTC)
thread_title: Drug-drug interactions

message: NSAIDs have some warning about alcohol, and I remember this being mentioned to me in person. Should we include something about alcohol and naproxen in the article? -User:Ick) 06:36, 3 September 2007 (UTC)
replies: text:  Absolutely. I was treated in the emergency room last night and told to take Naproxen. They told me that drinking while on the medication is quite serious and extremely dangerous. Sorry that I do not have an article citation on this; but I could tell my ER doc was quite serious about this. 24.251.84.221 02:05, 18 October 2007 (UTC)

text: Also a non-expert, but I think I've heard that some NSAIDs (Tylenol) have an interaction with ethanol that might lead to liver damage, whereas the others have the (fairly) mild risk of gastric upset (or more serious damage with long term use). None of that is meant to be put in the article, just a suggestion for a direction in which it might be developed, using WP:RS's. DavidOaks (talk) 13:32, 25 August 2010 (UTC)

text: That is not a reliable source for assessing DDIs. Biochemistry&Love (talk) 02:33, 4 May 2017 (UTC)
thread_title: Alcohol

message: I added the trade name 'Naprogesic'. Naprogesic is a Naproxen Sodium variant sold in Australia. Not 100% sure if the trade name should be on that list, ob I don't have access to the others to rtfm. Thoughts? 220.240.227.91 09:11, 6 February 2006 (UTC)
thread_title: Naprogesic

message: problem solved. --84.172.231.31 19:28, 4 March 2007 (UTC)
thread_title: Citations

message: Naproxen tablet thumb|center
CPO792 20:01, 15 May 2007 (UTC)
replies: text: Thank you! I'll add this to the article. ―Biochemistry🙴❤ 21:16, 17 May 2017 (UTC)
thread_title:  Naproxen Sodium tablet photograph 

message: i think it's known that naproxen sodium can cause stevens-johnson syndrome. 
http://en.wikipedia.org/wiki/Stevens-Johnson_syndrome  —Preceding unsigned comment added by 195.112.144.194 (talk) 08:18, 22 November 2007 (UTC)
replies: text: About "addiction": It's worth distinguishing between addiction and physical dependence.Opiates cause chemical dependency in all people who take them long term, but addiction is relatively rare in pain patients who are not already addicts. Addictive behavior includes obsessive thoughts about the drug, taking more of the drug than is needed to control pain--i.e., getting high--and an inability to function well in day to day life because of abusing the drug. Chronic pain patients may cope very well, not abuse the drug (get high), and even forget to take it (as opposed to thinking obsessively about it).Eperotao (talk) 17:24, 23 May 2008 (UTC)
thread_title:  Adverse Effects 

message: Naproxen is an oblong White Pill with the medical imprint code "IP110" following parallel score on the back which is for the patient using the drug can half it.
I think that description should be removed (or ammended), because not all Naproxen tablets look like that, the ones I get are blue, don't have "IP110" nor a score on it. Kyprosサマ (talk) 05:47, 18 January 2009 (UTC)
thread_title: Structure and details

message: I removed the sentence, "Naproxen was designed...while...trying to discover a cure for the common cold" because it wasn't supported by the source cited.  However, if the part of the statement excerpted above is actually true, then it should be re-added with proper sourcing. Bwrs (talk) 16:21, 21 February 2009 (UTC)
thread_title:  Was the discoverer of Naproxen trying to find a cure for the common cold? 

message: While this press release says Aleve isn't available over-the-counter in Quebec, I can assure you that it is available "behind the counter," having bought it here in Montreal several times since mid-July. There is evidently some confusion about the exact meaning of "over-the-counter" here. The article on OTC drugs discusses "restricted OTC substances", which are drugs available without a prescription but stored behind the pharmacy counter and dispensed by the pharmacist. I would say these are still considered OTC drugs, even if they're not on the general pharmacy shelves. "Over-the-counter" is a confusing term anyway. 
Further complicating things is the Aleve website, which reads "Sorry, ALEVE® is not available in BC/NFLD at this time. Coupon not valid in Quebec." Does this mean Aleve isn't available at all in B.C. and Newfoundland-Labrador? Or is it available behind the pharmacy counter? I'll be sending an email to the Bayer representative listed in the press release to ask for clarification. Puck35 (talk) 19:06, 16 August 2009 (UTC)
replies: text: Aleve *is* available OTC in NL.  Perhaps they obtained permission to do so after the original press release referred to in this article.  I can personally confirm but can find nothing official on Bayer.ca or aleve.ca other than the coupon is valid in NL. 174.116.18.211 (talk) 21:58, 16 January 2010 (UTC)
thread_title:  Aleve is available in Quebec 

message: I deleted this section because its bullshit and someone put it back in.
Go read the study in source 5.  Theres no statistical significance.  —Preceding unsigned comment added by 98.209.40.98 (talk) 17:20, 19 November 2009 (UTC)
thread_title:  risk of heart attack and stroke 

message: The article currently concludes with "The National Institutes of Health prematurely terminated a randomized clinical trial[5] of naproxen and celecoxib for prevention of Alzheimer's disease, after preliminary data suggested similar effects to Vioxx, such as heart attack or stroke, in patients taking naproxen."  However, the cited source actually states "For celecoxib, ADAPT data do not show the same level of risk as those of the APC trial. The data for naproxen, although not definitive, are suggestive of increased cardiovascular and cerebrovascular risk." [emphasis added].  It seems that the WP article is over stating the case for naproxen--at least the wp claim doesn't seem to follow from the cited source.  Ann arbor street (talk) 20:33, 9 January 2010 (UTC)
thread_title:  premature? 

message: I am currently taking brand name Vimovo, 500mg/20mg combination of naproxen and esomeprazole.  It was prescribed to me for shoulder tendinitis.  I thought I might find more information about it here on Wikipedia, but it seems to be new to you.  The NSAID-PPI combination drug is apparently supposed to reduce the chance of NSAID-related ulcers.  It appears that Axorid is a similar brand, with different ingredients.  I'd edit this article or the other, but this type of combination drug seems to warrant its own page.  I'll leave it to others to decide what, if anything, to do with this.
24.57.210.141 (talk) 02:08, 30 June 2012 (UTC)
thread_title:  In combination 

message: Why is it called Naproxen Sodium? The chemical formula states that there isn't actually any sodium in it. 2601:8:8900:436:8006:E424:8DA8:635D (talk) 19:30, 23 February 2014 (UTC)
replies: text: This article is not about Aleve, Naprosyn etc which are Naproxen Sodium, a different drug from Naprpoxen which is not water soluable and may not be medically useful. The article is probably wrong that "Naproxen _and_ naproxen sodium are marketed under various brand names ...". Certainly the m.w. and other chemical info is wrong about the drug people actually get. 73.81.150.65 (talk) 07:56, 3 February 2017 (UTC)
thread_title:  Why Sodium? 

message: I can't find this pill in Drugs.com and Lexi-Comp. Does anyone have proof that this is naproxen? Doc James, maybe you have something?
―Biochemistry🙴❤ 21:27, 17 May 2017 (UTC)
replies: text: I can get another picture next time I am at work. As a generic there will be 100s if not 1000s of examples. Doc James (talk · contribs · email) 00:12, 20 May 2017 (UTC)
replies: text: Thanks! (: ―Biochemistry🙴❤ 13:35, 20 May 2017 (UTC)
thread_title:  Picture Authenticity 

message: Teva Naproxen EC 500 (Enteric coating), EC are easier for stomac.
:Thanks!―Biochemistry🙴❤ 02:15, 25 January 2018 (UTC)
thread_title:  EC 

message: This article does not explain the difference between Naproxen and Naproxen Sodium.  In "Sodium Chloride," Sodium and Chlorine are elements. Sodium is metal and with chlorine the sodium chloride salt is produced.  But the name "Naproxen Sodium," is not an analogous name.  I have run across on several site the statement that "220 mg of Naproxen sodium 'has' 200 mg of Naproxen." I would like this article to explain what that means.  Also I would like to know why this drug is sold in 220 mg pills, exclusively over the counter I think; yet it may be prescribed in 500 mg pills. 220 mg does not match with recommended dosages (neither does 440 or 660 mg.)(PeacePeace (talk) 00:39, 7 September 2019 (UTC)
replies: text: It actually does seem to be pretty analogous, in the sense that Naproxen Sodium is the sodium salt form of the drug. Per drugs.com "Naproxen comes in two forms - either as the base naproxen or as the salt form naproxen sodium. Both the base and salt forms work the same way to relieve pain. There is one difference -- naproxen base on a milligram-per-milligram basis is slightly stronger than naproxen sodium. Here’s how it works out -- 220, 275, or 550 mg of naproxen sodium equals 200, 250, and 500 mg of naproxen, respectively. However, you don’t need to worry about any conversion as these slight differences are already taken into account when doses are determined."  And from Dailymed "The sodium salt of naproxen has been developed as a more rapidly absorbed formulation of naproxen for use as an analgesic.... The different dosage forms of naproxen are bioequivalent in terms of extent of absorption (AUC) and peak concentration (Cmax); however, the products do differ in their pattern of absorption.... After administration of naproxen tablets, peak plasma levels are attained in 2 to 4 hours. After oral administration of naproxen sodium, peak plasma levels are attained in 1 to 2 hours. The difference in rates between the two products is due to the increased aqueous solubility of the sodium salt of naproxen used in naproxen sodium." I'm not sure in regards to the status of drugs.com or dailymed are in regards to being WP:MEDRS but even if they aren't I'm sure the same info could be attained from sources that meet the MEDRS criteria and added, doesn't seem to be particularly contentious or anything. AmbivalentUnequivocality (talk) 09:21, 8 September 2019 (UTC)
replies: text: On second look some of this info (about the differing rates of absorption) is already present in the article. AmbivalentUnequivocality (talk) 09:24, 8 September 2019 (UTC)
thread_title:  Naproxen vs Naproxen Sodium 

message: EOx redirects to this page but is not referenced in the article at all. EOx is also used for electrochemical oxidation. The current redirect should be removed since it is not exclusive or expected IMO. Whether it should point to electrochemical oxidation is open to debate but it seems stronger to me than Naproxen.  — Preceding unsigned comment added by 2601:19B:200:D340:94E3:6F16:1AE9:484F (talk) 02:16, 12 April 2023 (UTC)
thread_title:  EOx redirect removal request