Talk:SK channel

message: Edits have been created by Bethany Chaves, Matt White, and Ryan Burns as a part of a Wikipedia article project. My group topic is the SK channel at Boston College.  These changes were major, though much of the original information on this page was left 'as is.'  Additional edits and criticism are welcome.  All three group members contributed equally to the new page seen.  The image added was created on Photoshop by Ryan Burns.
Ryburns83 (talk) 23:09, 1 November 2012 (UTC)
thread_title: Untitled

message: We have tweaked the page a bit. We have updated the language in both sections regarding blockers and modulators so as to imply specificity to small SK subtypes.  We have also revised vague and confusing language about NMDA and AMPA receptors in the LTP-related material.  Finally, we added the missing citations to the Parkinson's section and clarified information regarding what TH+ and TH- mean, phenotypically. Ryburns83 (talk) 19:17, 30 November 2012 (UTC)
thread_title: Revised Edition

message: Good article! I have a few suggestions. In the “Blockers” and “Modulators” sections, you often say “all three types of SK channels,” but above you describe four types of SK channels. Is SK4 an SK channel? In the “Synaptic plasticity and long term potentiation” section, you write that: “SK channels are coupled to NMDA receptors, which, in turn, are coupled with AMPA receptors, another ligand-gated channel that permisses cation influx.” I think you should change the wording of this sentence so that it doesn’t seem like you mean that NMDA receptors and AMPA receptors bind each other at the postsynaptic density. Also, you need to include citations in your “Role in Parkinson’s Disease” section; so far there are none. Overall, good job! Reedich (talk) 16:03, 29 November 2012 (UTC)
thread_title: Review

message: *Hi SK Channel group! Great layout of your article overall - it matches many of the other wiki site on proteins to make a cohesive site. The images are also great and impressive considering the process needed to put them up on this site, well done. I think you should think about adding some images in the blockers section, as this would show how structure dictates function in this sense. I also recommend beefing up the function section, especially how Ca-activated potassium channels contribute to repolarization, and how presence can be detected by raising intracellular calcium (info from our book), as well as add in function how they are distinguishable from other Ca-activated K channels. As far as the LTP section, find some sources on details of how SK channels are coupled to NMDA receptors and add a bit more to this section. Also, make sure to tag some of the other “lingo” that has a link to another wiki page (you did a pretty good job of this throughout the article, just don't miss any). Lastly, you have a good amount of sources. Good work! Ritterlb (talk) 21:15, 19 November 2012 (UTC)
thread_title: Peer review

message: Excellent detail and organization overall. However, I feel that some more information regarding the discovery of this channel would be helpful. Was there a particular drug or other chemical compound whose mechanism and/or effects became the impetus for studies on structure and function of the channel, for example?
Also, does the SK channel play a role in long-term depression? (Long-term potentiation is mentioned; if there is a role in long-term depression, it would be interesting to see how the roles of the channel relate.)
Progress looks good!
Marko Tkach (talk) 05:33, 19 November 2012 (UTC)
thread_title:  Peer Review - Marko