Talk:Hematopoietic stem cell transplantation

message: The article says research was performed at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s. But the FHCRC did not exist until 1976. E. Donnall Thomas was affiliated with the precursor foundation. According to Wikipedia's own page on FHCRC.
Dandante (talk) 07:43, 29 November 2008 (UTC)
thread_title:  Chronological Error 

message: How does the donor feel after donating? Any side-effects to Donor? Any scars or hints or surgery to donor? Weakness??
Thanks.  —Preceding unsigned comment added by 67.175.105.145 (talk) 23:52, 16 May 2008 (UTC)
thread_title: Risks to donor

message: Older versions of this article (prior to having it's title changed from BMT to HSCT) can be viewed on the old BMT history page.  Mfero 16:31, 1 March 2007 (UTC)
replies: text: Ouch! That is not the preferred way to do it... I'll see if I can get an admin to merge the histories. // habj 09:27, 26 June 2007 (UTC)

text: Page historied merged by AzaToth. // habj 21:18, 26 June 2007 (UTC)
thread_title: BMT article history

message: I've expanded most of the sections on the Bone Marrow Transplant page.  My apologies if I messed anything up.  
I'd like to know if anyone has an opinion about moving the page to "Hematopoietic Stem Cell Transplant"?  "Bone mone marrow transplant" would then be a redirect.  Even though HSCT is more modern and accurate than BMT for the topic it is still a little more awkward.  Also there are a huge number of links to this page and probably many of them should be changed.Mfero
:No, keep it here. Most lay readers will not have a clue what a haematopoeitic stem cell is, and the fine distinctions between BMT and HSCT. Just redirect HSCT here. JFW | T@lk 06:48, 11 July 2005 (UTC)
replies: text: I totally agree with the first guy, that this article really should be titled HSCT, with a redirect from the bone marrow transplant title to HSCT main page.  Very few patients get bone marrow transplants anymore, since peripheral blood stem cell transplants are safer and more effective...I think I'm going to do it tonight, since this doesn't seem like a very active concern--64.166.186.217 23:33, 15 February 2007 (UTC)

text: I just got the SHOCK - I was editting this page yesterday and never noticed the "merge" suggestion, and there it is, the mirror page. I definitely agree that it should be sone, and the re-direct solves any issue of technical correctness or popularity for readers. But have the technical difficulties prevented the merge all these months? I take it that there is no wiki tool to accomplish this. If consensus exists already, I would try maybe at the weekend (if the tax returns dont get in the way) - any volunteers to assist in proofreading?io_editor (talk) 02:05, 9 April 2008 (UTC)
thread_title:  BMT article title

message: This page currently has a large disclaimer stating that it has been suggested to merge it with the article entitled Stem cell transplantation.  The latter article is not a really a new article but is derived from the Bone marrow transplant article that I contributed to several years ago.  The biggest change seems to be the photograph showing bone marrow being aspirated in the operating room.  
IMO the current (HSCT) article is has become messy.  I don't mind the aspiration photo on the SCT page but it should be made clear that this refers to the older method of harvesting marrow under anesthesia as opposed to a peripheral blood stem cell harvest.   I suppose the real question is whether this the name of this article should be renamed from 'Hematopoietic Stem Cell Transplantation' to simply 'Stem Cell Transplantation'.  Even though I think the Stem Cell Transplant version looks better I would argue that the name should not be changed.  The reason is that the term stem cell transplant could, in theory, refer to organs other than the blood and bone marrow and  is not specific enough for this article.   
Thus I would be in favor of the following:
1. Keep Hematopoeitic Stem Cell Transplantation as the primary article.
2. Adopt the text (and photo) from 'Stem Cell Transplant' --or at least clean up the current version of HSCT.
3. Delete the (redundant) 'Stem Cell Transplantation' page.   
4. Make 'Stem Cell Transplantation' redirect here.
Any thoughts?  --Mfero 00:43, 25 October 2007 (UTC)
replies: text: I just got the SHOCK - I was editting this page yesterday and never noticed the "merge" suggestion, and there it is, the mirror page. I definitely agree that it should be sone, and the re-direct solves any issue of technical correctness or popularity for readers. But have the technical difficulties prevented the merge all these months? I take it that there is no wiki tool to accomplish this. If consensus exists already, I would try maybe at the weekend (if the tax returns dont get in the way) - any volunteers to assist in proofreading?io_editor (talk) 02:05, 9 April 2008 (UTC)
thread_title: Merge with 'Stem Cell Transplant'?

message: Myelodysplasia is a common indication for allogeneic transplants in adults, second only to AML in terms of frequency.  The risk/benefit ratio depends on the age of the patient, donor availability, features indicating a high risk of transformation to AML, and the expertise level of the transplant center.
Mfero 20:59, 17 September 2005 (UTC)
thread_title:  Conditions treated with BMT 

message: "In the case of a bone marrow transplant (BMT), the HSC are removed from a large bone of the donor, typically the pelvis, through a large needle that reaches the center of the bone. The technique is referred as a bone marrow harvest and is performed with general anesthesia because literally hundreds of insertions of the needle are required to obtain sufficient material."
I thought this was actually done under a local, which would explain why people say that donating bone marrow is extremely painful. Can someone clear this up for me? --El Zilcho 17:18, 22 March 2006 (UTC)
replies: text: Bone marrow harvests are generally done in the operating room under general anesthesia.  On the other hand, a stem cell transplant can be also done through a peripheral blood collection of stem cells (after the bone marrow has been stimulated with medication).  Andrew73 19:32, 22 March 2006 (UTC)
thread_title:  General anesthetic? 

message: Hi. I tried to add an external link to the EBMT website, but it was removed. I would just like to know why it doesn't qualify and where could it be added? Thanks. Melisa —The preceding unsigned comment was added by Mfero (talk • contribs).
:A link to EBMT should be fine. Not sure why it was removed (perhaps an innocent casualty of a mass spam deletion), but go ahead and re-add it. MastCell 17:23, 1 March 2007 (UTC)
replies: text: Is it just me, or is the third external link an advertisement for a company that wants your stem cells? Advertising has to be against some sort of wikipedia policy. If nothing else then for writing the description in the first person. SkaryMonk (talk) 17:26, 27 May 2008 (UTC)
thread_title:  External Links 

message: Just wondering.  The side effects of autologous and allogeneic stem cell transplantation are reasonably different. This is intimated in the paragraph about autologous transplant but I'm wondering if this neds to be clarified, say after the section on allogeneic stem cell complications.. ie. indications, method, outcomes and complications for autologous so that readers don't get them confused?  Markjohndaley 14:43, 14 June 2007 (UTC)
replies: text: I think that's a good suggestion. Feel free to go for it; I've been meaning to work on this page for awhile but not sure when I'll get around to it. MastCell Talk 16:22, 14 June 2007 (UTC)
replies: text: I agree. Autologous SCT has sufficiently different indications, processes and results (side effects etc.) from Allogenic to warrant its own section (if not its own full blown page). Go for it. Lorangriel 16:25, 14 June 2007 (UTC)
thread_title:  Autologous as its own section? 

message: The article lacks a history section. When was the first bone marrow transplant performed, etc. // habj 06:03, 26 June 2007 (UTC)
thread_title:  History 

message: History merge completed! →AzaToth 18:33, 26 June 2007 (UTC)
thread_title:  Historymerge 

message: There could be a section on what conditions are prohibitive in marrow donors. For example, I think the British NHS does not accept donors with rheumatic conditions e.g. lupus, rheumatoid arthritis etc. 212.179.71.70 (talk) 08:48, 31 December 2007 (UTC)
replies: text: While there are some absolute barriers to donation, which vary from organization to organization, most cases are a bit more fluid. The decision about whether to use a donor with certain health conditions may be individualized to take into account the known risks to the donor and recipient as well as the seriousness of the donor's condition and how serious and immediate the need for a transplant is, as well as the availability of alternate donors or stem cell sources. That said, any sourced info you can dig up would be useful to add. MastCell Talk 20:27, 31 December 2007 (UTC)

text: The rules on this issue depend upon the register.  For instance, the Anthony Nolan register in the UK does not impose this bar but instead excludes people if they "are involved in high-risk sexual practices that may increase [their] exposure to sexually-transmitted diseases."  The definition of high-risk sexual practices is left up to the donor's best judgement, since these may vary widely whether the donor is homosexual or heterosexual.  In the USA, there are a number of different registries, and I don't know the rules for all of them, but the largest (the NMDP) excludes men who've had sex with men in the past five years.Procrastinator supreme (talk) 16:40, 30 May 2012 (UTC)
thread_title:  Who can donate?  

message: In graft v tumor effect, someone was trying to say something, and it came out wrong: "This lower rate of relapse accounts for the increased success rate of allogeneic transplants compared to transplants from identical twins, and indicates that allogeneic HSCT is a form of immunotherapy." Am referring mainly to fist clause, did they mean HLA-mis-matched v HLA-matched allogeneics? And where is the source?? New to me....io_editor (talk) 02:32, 9 April 2008 (UTC)
replies: text: If you compare syngeneic transplants (that is, from one identical twin to another) with allogeneic transplants (between HLA-matched or mismatched individuals), the allogeneics will have lower relapse rates (of course, they'll also get GVHD). This difference in relapse rates between syngeneic and allogeneic transplants was one of the main pieces of clinical evidence for the existence of an immunologic graft-vs.-tumor effect. Does that make sense? It needs to be written more clearly. This article has been on my list for awhile; hopefully I can help out on it soon. MastCell Talk 04:49, 9 April 2008 (UTC)
replies: text: Well, my brain registered just siblings, not identical twins, when the comparator wasn't autologous. There must be on the order of 100-300 per year of such HSCTs worldwide. Funny ordering of logic (general plus the obscure) but all is correct, so am inclined to leave it. Actually I think this is a great WikiMed page (although it could have a dozen more cites) - simply because it manages to avoid going off-tangent, except for such interesting details.io_editor (talk) 01:03, 12 April 2008 (UTC)
thread_title: Someone was trying to say something

message: It doesnt really work that Indications is up the page, and that this is down the page. Suggestions? Cant think of any, other than to move the list up, even if that means removing some prose. Will leave it alone for now.io_editor (talk) 02:43, 15 April 2008 (UTC)
thread_title: Indications

message: This page currently has a large disclaimer stating that it has been suggested to merge it with the article entitled Stem cell transplantation.  The latter article is not a really a new article but is derived from the Bone marrow transplant article that I contributed to several years ago.  The biggest change seems to be the photograph showing bone marrow being aspirated in the operating room.  
IMO the current (HSCT) article is has become messy.  I don't mind the aspiration photo on the SCT page but it should be made clear that this refers to the older method of harvesting marrow under anesthesia as opposed to a peripheral blood stem cell harvest.   I suppose the real question is whether this the name of this article should be renamed from 'Hematopoietic Stem Cell Transplantation' to simply 'Stem Cell Transplantation'.  Even though I think the Stem Cell Transplant version looks better I would argue that the name should not be changed.  The reason is that the term stem cell transplant could, in theory, refer to organs other than the blood and bone marrow and  is not specific enough for this article.   
Thus I would be in favor of the following:
1. Keep Hematopoeitic Stem Cell Transplantation as the primary article.
2. Adopt the text (and photo) from 'Stem Cell Transplant' --or at least clean up the current version of HSCT.
3. Delete the (redundant) 'Stem Cell Transplantation' page.   
4. Make 'Stem Cell Transplantation' redirect here.
Any thoughts?  --Mfero 00:43, 25 October 2007 (UTC)
replies: text: Many months later, its time to do it, exactly as was suggested above. Step 2 is done, and Steps 1, 3 and 4 can be done now. Bone marrow transplantation would remain separate. I assume an Admin is needed to formalize.io_editor (talk) 16:55, 19 April 2008 (UTC)
thread_title: Merge with 'Stem Cell Transplant'? (''proposal copied from above'')

message: How does the donor feel after donating? Any side-effects to Donor? Any scars or hints or surgery to donor? Weakness??
Thanks.  —Preceding unsigned comment added by 67.175.105.145 (talk) 23:51, 16 May 2008 (UTC)
thread_title:  Risks to donor 

message: Please consider adding Syngeneic Stem Cell Transplant as it is part of a stem cell transplantation type in which a twin sibling is a donor and there is no graft versus host disease.  I don't understand why it was left out.  It is a rare procedure, but it is part of the SCT process for those who are lucky enough to have a twin sibling.
Gina2009 (talk) 23:41, 2 January 2009 (UTC)
replies: text: Good point. I have added it. You are of course welcome to add to or edit what I have written. That's what Wikipedia is about - if you think something is wrong or missing, you can put it right! Rachel Pearce (talk) 15:54, 3 January 2009 (UTC)
thread_title:  Syngeneic Stem Cell Transplant 

message: Can autologous bone marrow transplant and autologous bone marrow be redirected to the sub title autologous in the section graft types. It would get those two links out of the cancer dictionary I am trying to prune of links.  —Preceding unsigned comment added by Seb1l (talk • contribs) 21:51, 7 June 2009 (UTC)
thread_title:  Proposed Redirect 

message: A diagram could help this article, but is beyond my talents.  Ideally, I feel it should convey something similar to the information carried in the top image or two from here: http://www.netterimages.com/images/vpv/000/000/005/5836-0550x0475.jpg
- Demonstrating autologous vs allogeneic transplantation
- Demonstrating that haematopoietic stem cells are infused into the recipient's bloodstream, and then embed themselves in the bone marrow
- Possibly also demonstrating the three possible allogeneic sources (PBSCs, bone marrow aspirate, cord blood stem cells), although this runs the risk of making the image a little crowded.Procrastinator supreme (talk) 20:29, 3 June 2012 (UTC)
thread_title:  Diagram request 

message: Hi.  This is my first time discussing any kind of edit on Wikipedia, so maybe a more experienced editor can help me.  It appears that the section on VOD does not contain updated information with regard to defibrotide.  Defibrotide does reduce the severity of VOD, yes, but it also reduces the incidence of VOD full-stop, among other benefits.  (Corbacioglu, Lancet 2012). Do I just type my suggested edits in the main page?  Thanks.      Emanresuymsti.  Emanresuymsti (talk) 10:26, 11 June 2012 (UTC)
replies: text: By all means, although if you have a reputable citation to give that would back the statement up, it would be ideal if you could include that.  Apologies for the late reply.Procrastinator supreme (talk) 21:45, 19 June 2012 (UTC)
replies: text: You can go ahead and edit the page, by all means. Go ahead and write up a mention in whatever part of our article you think makes sense. To add a citation to the Lancet paper, you can cut-and-paste the following:  where you want the reference to appear. That will generate a footnote and citation. It's not very intuitive, but don't be afraid if it doesn't come out right... someone will come along and help fix it. I'll probably go ahead and add the article myself once I have to time look at it. You may want to make clear that it deals excluively with a pediatric population. MastCell Talk 05:12, 21 June 2012 (UTC)
thread_title:  Updating defibrotide information 

message: doi:10.1182/blood-2014-05-566679 - total of 5 articles JFW | T@lk 12:20, 20 July 2014 (UTC)
thread_title:  Review series in Blood 

message: According to the CDC ( http://www.cdc.gov/ncbddd/dba/stem.html ): "The person’s blood type will actually change to that of the donor."
208.103.112.69 (talk) 13:35, 8 September 2014 (UTC)
replies: text: Unknown which term is used here, when they write about the blood type. Is not specified, it AB0 system. —Fnaq (talk) 09:27, 13 September 2014 (UTC)
thread_title:  Blood type change 

message: "The first physician to perform a successful human bone marrow transplant on a disease other than cancer was Robert A. Good at the University of Minnesota in 1968.[42] In 1975, John Kersey, M.D., also of the University of Minnesota, performed the first successful bone marrow transplant to cure lymphoma. His patient, a 16-year-old-boy, is today the longest-living lymphoma transplant survivor.[43]"
Isn't lymphoma a type of cancer? Am I missing something here?
IAmNitpicking (talk) 18:42, 28 April 2015 (UTC)
thread_title:  History: isn't lymphoma a type of cancer? 

message: The most recent (as I write this) change is to link to the Annual Report of the World Marrow Donors Assocation. Unfortunately it can't be used without logging in. Is that a valid reference for a Wikipedia article? Honest question, I do not know the policy.
IAmNitpicking (talk) 14:59, 18 November 2015 (UTC)
thread_title:  WikiPolicy question: links to members-only sites 

message: Hello fellow Wikipedians,
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thread_title:  External links modified 

message: The Medical uses section already mentions that autoimmune diseases like multiple sclerosis can potentially be treated with HSCT. Could the diseases mentioned later on be added to that bullet point or removed? 2600:1002:B01E:5A8C:0:4C:8EB1:2401 (talk) 08:48, 8 October 2022 (UTC)
thread_title:  Why "Other autoimmune neurological diseases" section? 

message: — Assignment last updated by Sbplr5 (talk) 17:23, 3 November 2023 (UTC)
thread_title: Wiki Education assignment: LLIB 1115 - Intro to Information Research

message: Hey, @Coskunahmet38, would you care to convert that inline link into a reference? IAmNitpicking (talk) 03:08, 14 January 2024 (UTC)
thread_title:  Haploidentical