Talk:Valaciclovir

message: The profit from the few Herpes infected people foolish enough to take Valaciclovir with the immediate side effect induced discontinuation cannot cover the cost of the ridiculously numerous commercials in an honest air-time market.
We all know, or should know, everything is commercialized at the Alter of Mammon for profit except in cases of malice. Alphaquad 23:27, 13 March 2007 (UTC)
replies: text: There are probably too many drug commercials on USA television. That doesn't mean Wikipedia is the right place to start analysing this phenomenon.  JFW | T@lk 23:00, 18 March 2007 (UTC)
replies: text: As you wish master control-tripAlphaquad 02:05, 19 March 2007 (UTC)
thread_title:  Financial Logic for Malice 

message: I was wondering what the source is for the statement that valaciclovir is contraindicated in immuno-suppressed patients. I can't find anything on this. In the Netherlands, for example, it does have an indication for treatment in HIV-infected patients.  (in Dutch). It also seems as if it is being used in other countries, for example in this study , where it has been used for the management of the HIV-1 infection itself. Jorishartman 09:07, 18 August 2007 (UTC)
replies: text: I was curious about the use of valaciclovir in immuno-suppressed patients as well. I know for a fact it is commonly used for transplant patients as an antiviral prophylactic  similar to the use of gancyclovir for CMV.  --Skelln1 07:09, 18 September 2007 (UTC)
replies: text: There's has been at least one case of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in an HIV-patient, but this patient was taking an unsual high 8mg QD of valaciclovir. Other than that, I can only find sources that indicates the use of valaciclovir to treat HSV also in immunocompromised patients, and have removed the (unsourced) contraindication from the article. - Meewam (talk) 11:35, 8 May 2010 (UTC)
thread_title:  Valaciclovir and HIV 

message: I removed a mention of "Christine Moraski" as the creator of valaciclovir. I can find no significant mention of that name on Google or in my Pharmacology textbooks (unsurprisingly). The edit was made by IP here wihout citation, so I think it's probably a hoax. Since it's just a simple esterification of a drug created by someone else, I'm sure GSK just set a bunch of staff scientists on trying slight modifications of the drug, and this one panned out...nobody would have been credited as the "creator". - Draeco (talk) 16:33, 14 May 2008 (UTC)
thread_title:  Creator? 

message: Name should be 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate  —Preceding unsigned comment added by ChemSpiderMan (talk • contribs) 00:26, 30 May 2008 (UTC)
thread_title:  IUPAC Name is lacking stereochemistry 

message: The molecular diagram has been spammed by user at 124.180.148.160
Limeyguru (talk) 00:03, 1 July 2009 (UTC)
thread_title:  Molecular diagram spammed 

message: Halford et al. (1997) Virology 238, 53-63 provides indirect evidence that the sentence "It is inactive against latent viruses in nerve ganglia"  is not accurate. That paper demonstrates that Acyclovir (the active ingredient of valaciclovir) blocks cytokine gene expression in trigeminal ganglia latently infected with HSV-1. Therefore, there should be a clarification of what "is inactive" means, or an explanation of why valaciclovir affects, but acyclovir does not affect, latent viruses in sensory ganglia.
:It means that the drug does not eliminate the latent virus from the nerve ganglia. Ruslik_Zero 06:38, 6 May 2014 (UTC)
thread_title:  "It is inactive against latent viruses in nerve ganglia" - citation or clarification needed 

message: looks like GSK won patent cases in court
US http://www.drugs.com/availability/generic-valtrex.html
Canada http://www.drugbank.ca/drugs/DB00577
Canada	expires	2017-01-17 and 2015-10-13
US expires 2016-07-19  — Preceding unsigned comment added by 76.176.108.8 (talk) 18:02, 29 January 2015 (UTC)
replies: text: Neither source directly states that. - SummerPhD (talk) 00:50, 31 January 2015 (UTC)

text: Quotes from forums fall under WP:SPS and cannot be used on Wikipedia. - SummerPhD (talk) 00:50, 31 January 2015 (UTC)
thread_title:  no more generic ? 

message: Add History section.
Separate and update current "Mechanism of Action" section into "Mechanism of Action" and "Pharmacology" (to include Pharmacokinetics and Pharmacodynamics).
Add Drug Interactions section.--Mparagas18 (talk) 21:56, 29 July 2019 (UTC)
replies: text: Please make sure all group members assign themselves to this article before making their individual edits. Thanks. Health policy (talk) 05:33, 31 July 2019 (UTC)
thread_title:  Foundations 2 2019, Group 3b goals 

message: --Inshaqari (talk) 16:22, 6 August 2019 (UTC)
thread_title:  Foundations II Group 3A peer review 

message: https://clinicaltrials.gov/ct2/show/NCT04710030 Ethan hines (talk) 06:48, 22 February 2023 (UTC)
thread_title:  Valacyclovir for Mild Cognitive Impairment (VALMCI) 

message: The first sentence states "Common adverse drug reactions (≥1% of people) associate with...".  Shouldn't that instead be "...(≤1% of people)..."?  If you agree with full confidence render the edit if you like, or I'll do so within a couple of weeks.  Cheers!  H Bruce Campbell (talk) 11:44, 14 February 2024 (UTC)
thread_title:  Adverse effects