Talk:Κ-opioid receptor

message: What's with the capitalization on the O?
Miserlou 03:43, 6 November 2007 (UTC)
thread_title:  Capitalization 

message: I'm not sure it's correct at all that kappa agonists don't induce dysphoria. I can find numerous papers by respected authors in the field within the last year that refer to kappa-induced dysphoria. Either the anonymous wikipedia editor is correct and the experts are under a misconception, or this page needs a serious rewrite. 160.62.4.10 (talk) 11:56, 7 April 2008 (UTC)
replies: text: Try to track down papers that describe how the dysphoria has been measured. If you find animal studies, take into account that dysphoria is a genuinely human term and that avoidance in animals can have other meanings. Сасусlе 12:45, 7 April 2008 (UTC)
thread_title:  Dysphoria 

message: Literally one out of every four sentences in this article talks about salvinorin A. This article is not entitled "salvinorin A", but "kappa opioid receptor". There's very little information about the kappa opioid receptor in the article, which was apparently written by someone who thinks the most noteworthy thing about this topic is whatever erowid says about it.
And the "Further Reading" section is longer than the actual article. --76.224.65.89 (talk) 01:52, 17 May 2008 (UTC)
replies: text:  Go ahead, it's a wiki :-) Cacycle (talk) 02:32, 17 May 2008 (UTC)
thread_title:  This article needs to be rewritten. 

message: I removed the uncited suggestion that Naloxone is effective at counteracting the effects of kappa agonists; on the Naloxone page it was suggest that the drug is effective at counteracting, specifically, salvia (ie: as a way to bring someone back from a hallucinogenic state), which seems a stretch, especially since the literature is mixed on whether or not it is effective in animal tests and other experiments, and ESPECIALLY when the drug itself is neither recommended, prescribed, or otherwise suggested to be used in such situations. SiberioS (talk) 04:10, 21 May 2008 (UTC)
thread_title:  Suggestion that naloxone... 

message: Just some of my thoughts...
2nd paragraph, reference to 44: must include short-term/long-term effect. Assuming long term (long term administration of a kappa agonist). Also, this isn't the point of the article referenced here. The writer should have picked a better reference - I thought it was funny.
4th paragraph: "although seemingly paradoxical" needs to be removed. It's rather subjective and that whole sentence is actually unnecessary.
Last paragraph: "The longer effects of kappa opioid agonism..." should be taken out as it doesn't flow with the topic sentence. Personally, I would take this whole paragraph out, since it's somewhat redundant and half of the paragraph lacks any reference.
It might be better organized if the article makes a clear distinction between the short term effect of kappa receptor agonism and the long term effect (leading to upregulation of mu receptors, etc.).
Opq4i (talk) 03:36, 13 October 2009 (UTC)
thread_title:  Treatment in Drug Addiction 

message: The article is listing some k-opioid agonists and antagonists incorectly. For example buprenorphine is listed as an agonist, when it's action is kinda mixed but mostly antagonistic. http://www.jneurosci.org/content/29/22/7341.full - " It [buprenoprhine] has mixed but primarily antagonistic actions on κ-opioid (KORs) and δ-opioid (DORs) receptors (Sadée et al., 1982; Richards and Sadée, 1985; Kajiwara et al., 1986; Leander, 1987; Zhu et al., 1997; Huang et al., 2001)." 
I would really appreciate if someone had the time to check all the other agonists/antagonists and make sure they're listed correctly.  — Preceding unsigned comment added by 84.248.161.232 (talk) 12:59, 8 March 2013 (UTC)
replies: text: That's been bothering me too. Yes, time. --Tryptofish (talk) 23:54, 8 March 2013 (UTC)
thread_title:  Incorrectly listed agonists/antagonists