Talk:Cervical intraepithelial neoplasia

message: CIN 4When following the reference for CIN 4, it must be noted that the author of the paper does not talk or make any reference to CIN 4. The author talks about CIN 1 to 3, afterwhich he talks about the next stage of "invasive carcinoma". This "invasive carcinoma" is also called FIGO stage 0, or TNM Category Tis. I did a  literature search and there is no mention about a CIN 4. I would like this seeing deleted. Objections??? Scubafish 15:40, 11 May 2007 (UTC)
replies: text: You're right, it's nonsensical. I deleted it -RustavoTalk/Contribs 19:19, 11 May 2007 (UTC)
thread_title: CIN 4

message: I am a medical doctor specializing in internal medicine.  I thought that the pictures in the Grades section were a bit confusing to those that may not understand CIN.  Thus, I’d like to add the following graphic to help Wikipedians better understand the stages of CIN:
I found this graphic on the following Web site and have obtained permission to post it on Wikipedia: http://www.thehpvtest.com/under-30/HPV-facts-cervical-cancer-faq.html#howlong 
Drsavard (talk) 15:31, 14 March 2008 (UTC)
thread_title: CIN Visual

message: Suggest that Cervical dysplasia be merged into Cervical intraepithelial neoplasia they both say they are the same thing.  Zodon (talk) 05:57, 26 August 2008 (UTC)
replies: text: Agree They are effectively the same and the dysplasia article has nothing much in it. I support moving the content (if any) here and linking dysplasia to CIN. Chaldor (talk) 07:51, 26 August 2008 (UTC)
thread_title:  Merge Cervical dysplasia 

message: Recently the section on LSIL and HSIL was added (copied from Bethesda System).  It needs some work to make the distinction between Pap results (cytology) and biopsy results (histology - CIN, etc.) clear.  It could use some work to summarize the material on histology (no point in just duplicating material.)
The section in question is what was removed in this edit.  (Sorry I didn't reproduce it here - a bit on large side).  Suggestions for how to clearly handle?  (Maintain distinction between cytology and histology (Pap vs. biopsy), and not duplicate material too much.)  Thanks.  Zodon (talk) 08:37, 6 April 2010 (UTC)
thread_title:  Integrating section from Bethesda System article 

message: eg. a cancer vaccine is in Phase II clinical trials for cervical intraepithelial neoplasia.. - Rod57 (talk) 12:46, 18 November 2016 (UTC)
thread_title:  Could have sections on Prevention, Clinical trials, Research 

message: - Article is in START status, would like to expand on article to include most/all components in the Wiki medicine Manual of Style: 
-Signs/symptoms
-Causes and Risk factors 
-Subsection: Genetics
-Pathogenesis / Pathophysiology
-Diagnosis (biopsy findings)
-Screening / Prevention 
-Treatment
-Outcomes/Prognosis 
-Epidemiology
-History
-Research directions
-Special populations (if possible)
-Would appreciate any feedback/questions/comments on proposed changes, thanks! 
Grisreyes (talk) 03:15, 14 March 2018 (UTC)
thread_title:  Proposed Changes  

message: Overall some minor word and stylistic changes could greatly improve this article. I’m not sure which sections you worked on, comments for each section below with section header marked by bullets. General comments:
*Fix capitalisation in section headers throughout (only first word should be capitalised)
*Consider defining or simplifying complex medical terms throughout (ex: squamous lesions of the anogenital tract)
*Define acronyms at first use, use consistent language to refer to the same things
*Clarify difference between HPV infection, CIN, cancer - seems ‘infection’ is used interchangeably with CIN throughout the article when CIN is not an infection, right? 
===Specific section comments===
*Header - Header could be simplified, for example first sentence could be broken up to make it more readable. Terms like “distinct degrees of differentiation” and “squamo-columnar” junction might be confusing to the lay person. Consider moving sentence about New Bethesda System classification to separate section
*Signs and symptoms - HPV - define or link to herpes article (definition appears in “Screening” section currently). Consider explaining link between HPV and CIN (HPV is risk factor for CIN?). Bethesda System sentence from header might fit best here.
*Prevention - Explanation of difference between primary and secondary prevention, or link to wiki articles) would be helpful here
*Causes and risk factors - This section would make sense as the first section (before signs and symptoms) since it explains 
*Pathogenesis/pathophys - “While infection with HPV is needed for development of CIN” >> is this the only way to get CIN? If so, that could be clarified in causes and risk factors section. “anogenital epithelium” term might be confusing to layperson
*Classification - “the location of the infection” >> should ‘infection’ be replaces with ‘lesion’ or some other word? Is this referring to CIN or HPV? HPV-associated >> add dash
*Treatment - “Treatment for higher grade CIN involves removal or destruction of the neoplastic cervical cells” >> consider replacing neoplastic with abnormal, or defining it
*Outcomes and prognosis - “Progression to cancer typically takes 15 (3 to 40) years.” >> clarify that the parentheses are a range
*History - consider adding a citation or two
Cheers and happy editing!
--Drus1a (talk) 01:08, 24 March 2018 (UTC)
thread_title: WikiProject medicine peer review

message: *Header - Header could be simplified, for example first sentence could be broken up to make it more readable. Terms like “distinct degrees of differentiation” and “squamo-columnar” junction might be confusing to the lay person. Consider moving sentence about New Bethesda System classification to separate section
*Signs and symptoms - HPV - define or link to herpes article (definition appears in “Screening” section currently). Consider explaining link between HPV and CIN (HPV is risk factor for CIN?). Bethesda System sentence from header might fit best here.
*Prevention - Explanation of difference between primary and secondary prevention, or link to wiki articles) would be helpful here
*Causes and risk factors - This section would make sense as the first section (before signs and symptoms) since it explains 
*Pathogenesis/pathophys - “While infection with HPV is needed for development of CIN” >> is this the only way to get CIN? If so, that could be clarified in causes and risk factors section. “anogenital epithelium” term might be confusing to layperson
*Classification - “the location of the infection” >> should ‘infection’ be replaces with ‘lesion’ or some other word? Is this referring to CIN or HPV? HPV-associated >> add dash
*Treatment - “Treatment for higher grade CIN involves removal or destruction of the neoplastic cervical cells” >> consider replacing neoplastic with abnormal, or defining it
*Outcomes and prognosis - “Progression to cancer typically takes 15 (3 to 40) years.” >> clarify that the parentheses are a range
*History - consider adding a citation or two
Cheers and happy editing!
--Drus1a (talk) 01:08, 24 March 2018 (UTC)
thread_title: Specific section comments