Talk:Progesterone

message: I apparently just did this simple procedure incorrectly, either way, I have been editing on here for a long time and it has been as of only recently that I have to go through these barriers to get my requests approved.  In any event, as I mentioned previously, I am conducting research independent-from any university although I have my neuroscience professor supervising me and I wanted to publish some of the findings about progesterone's effectiveness in treating traumatic brain injury.  It was recently approved for phase III of clinical trials, and I plan to point this fact out first before offering any definitive conclusions about the results.  However, TBI, (traumatic brain injury) look up how common it is, according to the CDC "TBI is a contributing factor in 30.5% of all injury-related deaths in the United States and responsible for a mind blowing estimated $76.5 billion in the United States in 2000" and recent statistics find that the injury rate is upwards of 3 million a year.  Mind you this includes people with concussions, however, this is also to say that people with these "simple" brain injuries could have access to better health care options. This is not your typical, media makes a big announcement about a potential break through and a person makes a run with it and then everyone is interested.  In fact, so far the opposite. 
In a attempt to reinforce why I should be allowed t post and edit at will, one because I am far more scared to post anything slightly irrefutable than anyone else I am about to publish my first real article and I am still only an undergraduate.  Point is that this treatment saves lives, and those who are injured and receive treatment are in better positions to heal and regain function faster.  The fact is, whether you (whoever in the hell edits these things, its wikipedia for Christs sake) will sadly or have known someone to fall down their stairs and hit their head, have a son or daughter get a concussion in school sports, or god forbid receive a head injury from a road side bomb while serving in Iraq or Afghanistan.  Guess I will attempt to make an impression here and add a quote and a reference, not in the specified manor but for credibility safe, -According to Representative Bill Pascrell (Democrat, NJ), TBI is "the signature injury of the wars in Iraq and Afghanistan." And, according to The Pentagon "Congress [Is] Studying Brain-Damage Therapy". ProPublica. Retrieved 2011-01-23. "Brave Americans who risked everything for their country and sustained traumatic brain injuries -- the signature injury of the wars in Iraq and Afghanistan -- deserve cognitive rehabilitation therapy to help them secure the best futures possible. It is unacceptable that the United States has been at war for nearly a decade and there is still no plan to treat these soldiers."
If I even now decided to stay up longer and go into the results of the findings, you would be so blown away, you would most likely contact me or the lead research directly.  The fact is, 1) if you go on pubmed there are some 214 articles published on the entire matter I believe, 2) these articles do not come close to displaying the results that I have independently confirmed in my own studies, and 3, we are at the vanguard of a medical treatment that for over the last 20 years has been static.  The most disappointing thing for me is that instead of being presented by wikipedia the time and opportunity to collectively get my ideas, thoughts, and arguments down in a manner that is persuasive yet unbiasis, educational yet straight forward, and cost effective.  I just wasted all my time writing this hopefully persuasive cover letter to allow me to avoid such time onsuming restrictions and post my finishing points starting over spring break in a cohesive and summarizing manor, that I am still able to conclude my research and work to publish my results.  Ill get started on typing up the actual research when it seems to be.  
Sam
Srut07 (talk) 07:48, 1 March 2012 (UTC)
replies: text: We can not publish preliminary findings from research that has not been published yet. What you can do is to summarize everything that has been published so far and mention the phase III trial that is in progress. Try to create a draft in your userspace so we can get an idea. Richiez (talk) 10:42, 1 March 2012 (UTC)
thread_title:  Edit request on 1 March 2012 

message: Seems the distinction could be clearer. Progestins are so diverse that trying to cover their effects in this article will bring only confusion. Richiez (talk) 21:56, 5 March 2012 (UTC)
thread_title:  Cleanup progesteron vs progestin effects/adverse effects 

message: I removed a trivia paragraph about Percy Lavon Julian and a WP:COPYVIO paragraph (about Mexican wild yams no longer being used in 1995 to produce progesterone) added to the Plants section by IP-hopping anonymous editor 71.123.25.175 (aka 141.149.208.54 / 71.123.29.191 / 71.182.123.65 / 71.123.17.215 / 71.182.107.102 / 70.16.52.193 / 70.16.61.75 / 71.182.100.111 /  71.240.244.35 / 71.123.31.25 / 71.240.247.110 / 70.16.49.248 /  71.182.108.43 / 71.182.98.194 / 71.182.111.225):
Upjohn is a pharmaceutical company located in Kalamazoo, Michigan whose main manufacturing</span> businessis making products from the soy sterols stigmasterol and sitosterolwhich come from the unsaponifiable fraction of soybean oil.Upjohn has been doing this since about 1959 when the plant was constructed andis America's only manufacturer of steroids.A small amount of steroids is made by a company in Mexicobut they --do not-- use Mexican wild yams as a raw material any more to extract diosgenin.The supply of wild yams is fairly limited but there is a very large supply of soybeans.It was a problem of both supply and chemistry."The chemistry using the soybean route is superior to that for the yam route."
taken from:
Shurtleff, William; Ayoagi, Akiko (2009). History of soybeans and soyfoods in Mexico and Central America (1877–2009):extensively annotated bibliography and source book . Lafayette, Calif.: Soyinfo Center. , p. 293:1066. Ball, Kenneth. 1995. The Upjohn Company's work with soy sterol products (Interview).SoyaScan Notes. May 11. Conducted by William Shurtleff of Soyfoods Center.
• Summary:Upjohn is a pharmaceutical company whose basic business in Kalamazoois making products from soy sterols,which come from the crude lipid faction of soybean oil.The company has been doing this since about 1959.The division of Upjohn that Ken works for is involved in selling bulk steroid products, all of which comes from soy lipids.Upjohn buys its raw material from Henkel and several other sources.They have sold androstenedione in the past to companies who further processed it chemically to make their own proprietary compounds.Ken is quite sure that no other company in America sells androstenedione or makes products from soy sterols.Upjohnis America's only major manufacturer of steroids.A very small amount of product is made by a company in Mexico,but they don't use Mexican wild yams as a raw material any more to extract diosgenin.The supply of yams is fairly limited but there is a very large supply of soybeans.It was a problem of both supply and chemistry.The chemistry using the soybean route is superior to that for the yam route.
Lynn4 (talk) 19:55, 16 April 2012 (UTC)
thread_title: Percy Lavon Julian trivia paragraph and copyright violation paragraph

message: I'm an undergraduate student studying biomedical engineering at Georgia Tech currently taking a senior level course in neuroscience. As an assignment, we were to edit a Wikipedia article, and I chose Progesterone as a treatment for TBI. I am requesting editing privileges for this article to edit the section on Brain Injury. Below is the included section edits along with their citations and I will add links to other articles after I am permitted to add what I've included:
* Brain damage
Studies as far back as 1987 show that female sex hormones have an effect on the recovery of traumatic brain injury.In these studies, it was first observed that pseudopregnant female rats had reduced edema after traumatic brain injury. Recent clinical trials have shown that among patients that have suffered moderate traumatic brain injury, those that have been treated with progesterone are more likely to have a better outcome than those who have not.
* Proposed Mechanism 
Damage incurred by traumatic brain injury is believed to be caused in part by mass depolarization leading to excitotoxicity. One way in which progesterone helps to alleviate some of this excitotoxicity is by blocking the voltage-dependent calcium channels that trigger neurotransmitter release.Secondary source/review article:   It does so by manipulating the signaling pathways of transcription factors involved in this release. Another method for reducing the excitotoxicity is by up-regulating the inhibitory neurotransmitter receptor, GABAA.
Progesterone has also been shown to prevent apoptosis in neurons, a common consequence of brain injury.  It does so by inhibiting enzymes involved in the apoptosis pathway specifically concerning the mitochondria, such as activated caspase 3 and cytochrome c. 
Not only does progesterone help prevent further damage, it has also been shown to aid in neuroregeneration. One of the serious effects of traumatic brain injury includes edema. Animal studies show that progesterone treatment leads to a decrease in edema levels by increasing the concentration of macrophages and microglia sent to the injured tissue.Secondary source/review article:  This was observed in the form of reduced leakage from the blood brain barrier in secondary recovery in progesterone treated rats. In addition, progesterone was observed to have antioxidant properties, reducing the concentration of oxygen free radicals faster than without. There is also evidence that the addition of progesterone can also help remyelinate damaged axons due to trauma, restoring some lost neural signal conduction. Another way progesterone aids in regeneration includes increasing the circulation of endothelial progenitor cells in the brain.Primary source/animal study:  This helps new vasculature to grow around scar tissue which helps repair the area of insult.
* Combination treatments
Vitamin D and progesterone separately have neuroprotective effects after traumatic brain injury, but when combined their effects are synergistic.  When used at their optimal respective concentrations, the two combined have been shown to reduce cell death more than when alone.  
  
One study looks at a combination of progesterone with estrogen.  Both progesterone and estrogen are known to have antioxidant-like qualities and are shown to reduce edema without injuring the blood-brain barrier. In this study, when the two hormones are administered alone it does reduce edema, but the combination of the two increases the water content, thereby increasing edema.Primary source/animal study: 
 
* Clinical trials
The clinical trials for progesterone as a treatment for traumatic brain injury have only recently begun. ProTECT, a phase II trial conducted in Atlanta at Grady Memorial Hospital in 2007, the first to show that progesterone reduces edema in humans. Since then, trials have moved on to phase III. The National Institute of Health began conducting a nationwide phase III trial in 2011.Secondary source/clinical study:  A global phase III initiative called syNAPSe also began conducting phase III trials. SyNAPSe is run by a Belgian/French private pharmaceutical company, BHR Pharma, who are currently conducting their trials in the United States, Argentina, Europe, Israel, and Asia.
E.K.Woodall  (talk) 19:25, 12 July 2012‎ (UTC)
: Hi.  Thanks for your contributions.  Have you read the above section?  Per WP:SECONDARY, secondary sources are strongly preferred. Of the citations that you have selected only #8 () is a secondary source. The others are all primary sources.  If you had chosen citations from this list, things would have been much simpler.  I would appreciate if you would go through your list of citations and substitute primary with secondary sources where ever possible.  Thanks.  Boghog (talk) 19:15, 12 July 2012 (UTC)
replies: text: If you haven't seen this yet, please check out User:Diberri's Wikipedia template filling tool (instructions).  Given a PubMed ID, one can quickly produce a full citation that can be copied and pasted into a Wikipedia article. This tool can save you a lot of work and ensure that the citations are displayed in a consistent manner.  Boghog (talk) 20:39, 12 July 2012 (UTC)

text: Nice work! Thank you for your contribution. Your text has now been added to the article.  There was already a short section on brain damage, so I tried to integrate your text with the previous text.  The section probably needs a bit more editing to remove some redundancy between the previous text and your text, but I think the present version is in reasonably good shape.  Cheers.  Boghog (talk) 06:54, 19 July 2012 (UTC)
thread_title:  Edit Request for Section on Brain Injury 

message: Hello.
Could you provide more information on the possible link between MS and progesterone, and what possible citations there might be for stating that in your article. I am a 36yo male, and I am curious if that link could be proven, not only for females, but males also, given the studies that males and females have the same levels of progesterone in their bodies, and if I read your article right, higher levels during pregnancy. 
Thank you. 
Traumaemt99 (talk) 00:31, 7 June 2013 (UTC)
thread_title:  Progesterone-Multiple Sclerosis Link  

message: Not mentioned in article. Is it a trade name? 86.159.197.174 (talk) 04:33, 22 August 2014 (UTC)
thread_title:  Why does "corporin" redirect here? 

message: Term not used in text. 81.159.93.150 (talk) 17:02, 7 March 2015 (UTC)
replies: text: Same question for "luteohormone", which also redirects here. 81.159.93.150 (talk) 17:04, 7 March 2015 (UTC)
thread_title:  Why does "luteol" redirect here? 

message: Should we split into progesterone and progesterone (medication)? Doc James (talk · contribs · email) 01:30, 20 November 2016 (UTC)
thread_title: Split

message: Can someone explain the meaning of (P4) at the top of this article?
Simon de Danser (talk) 10:22, 23 June 2017 (UTC)
replies: text: Nope, removed. Jytdog (talk) 13:33, 23 June 2017 (UTC)
replies: text:  How about...   P4; Pregn-4-ene-3,20-dione  — Preceding unsigned comment added by 2600:1702:3980:7CC0:0:0:0:2F (talk) 04:19, 20 March 2020 (UTC)
thread_title:  P4 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Progesterone. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20090109072721/http://cclnprod.cc.nih.gov/dlm/testguide.nsf/Index/CB26894E1EB28DEF85256BA5005B000E?OpenDocument to http://cclnprod.cc.nih.gov/dlm/testguide.nsf/Index/CB26894E1EB28DEF85256BA5005B000E?OpenDocument
*Added archive https://web.archive.org/web/20120415001340/http://lipidlibrary.aocs.org/history/Julian/index.htm to http://lipidlibrary.aocs.org/history/Julian/index.htm
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 08:53, 6 December 2017 (UTC)
thread_title:  External links modified 

message: I'm part of a 4 person group studying at UCSF School of Pharmacy. We are planning to edit several sections and below are the articles we plan to reference while doing our edits:
Section 2.2 Reproductive system
Horm Mol Biol Clin Invest, Progesterone in normal and pathological pregnancy, Gian Carlo Di Renzo, et al, 2016
https://pdfs.semanticscholar.org/beba/1f27d28656368ce6f8e8a7b4547178e811b4.pdf
Section 2.3 Breasts
Asi et al. Systematic Reviews, Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis, Noor Asi1, 2016
https://www-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/pmc/articles/PMC4960754/pdf/13643_2016_Article_294.pdf
Section 2.8 Brain damage
Cochrane Libary, Progesterone for acute traumatic brain injury (Review), Ma J, et al, 2016
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463867/pdf/CD008409.pdf
Jdinger123 (talk) 21:19, 30 July 2019 (UTC)
replies: text: Please make sure the remaining group members assign themselves to the article. Also, check instructions for adding citations, like so. Health policy (talk) 05:11, 31 July 2019 (UTC)
thread_title:  Foundation 2 Group 4b: Proposed Section Edits 

message: The section on where progesterone is made/synthesized and/or released from is missing. Hydra Rain (talk) 21:54, 3 August 2023 (UTC)
thread_title:  Not clear where progesterone is produced in humans 

message: Shouldn't be added a paragraph about use in trangender women as a part of cross-sex HRT? Beczky (talk) 22:28, 20 November 2023 (UTC)
thread_title:  Use in transgender women.