Talk:Proteasome

message: Although the proteasome article does include information regarding the ubiquitin proteasome system, it is important to recognize that the proteasome is only the final component of the ubiquitin proteasome system. The ubiquitin proteasome system is extremely extensive and has a high relevance to many areas of biomedical science e.g. cancer. Therefore I believe it is justified for this article exist in it's own right, but in a much more extensive form than at present.
:The above paragraph was copied from the article The Ubiquitin Proteasome System which was merged with this Proeasome article. --Splette  Talk 10:22, 19 October 2006 (UTC)
thread_title:  older entries 

message: Pharmacological information should relate primarily to bortezomib, the proteasome inhibitor used for multiple myeloma. JFW | T@lk 12:32, 1 November 2006 (UTC)
thread_title:  Bortezomib 

message: Motivated by the impressive diagrams of WikipedianProlific I'd like to have a go, too and draw one for the ubiquitin-proteasome-pathway. What steps do you think we should include (maybe starting from ubiquitination...) and do you know any good reviews about the topic? --Splette :) Talk 23:31, 2 November 2006 (UTC)
replies: text: Great idea - could be useful in the ubiquitin article also. There's overview with a very schematic diagram in this paper on the role of the proteasome in autoimmune disease, and a thorough but slightly unorganized review with diagrams in this paper - IMO the structural schematics with the alpha/beta/etc subunits in the second paper would be particularly nice. Opabinia regalis 07:31, 13 November 2006 (UTC)
thread_title:  Pathway diagram 

message: I think that this article is about ready for GA nomination... what do you all think? – ClockworkSoul 15:00, 2 December 2006 (UTC)
replies: text: I've got a bit of text left to add on the immunoproteasome and its products as MHC ligands, and Splette is planning to create a diagram or two soon, so I'd rather wait just a bit. On that general subject, though, have you heard from ShaiM recently at all? I think it would be great for the project if cell nucleus went to FAC, but since he did the balance of the work on that article, I'd hate to nominate it without him. Opabinia regalis 00:57, 3 December 2006 (UTC)
thread_title:  Consider for GA 

message: :copied from User_talk:Serephine
Is it really an organelle? I don't think of it that way, and the closest text I had on hand gives it the next classification down - "molecular machine" - which is not really specific enough to get its own category. Opabinia regalis 03:31, 19 December 2006 (UTC)
replies: text: I wasn't totally sure myself, however, I checked with a Google search (  ) and found the scientific community to largely refer to it as an organelle in addition to machinery. I couldn't find anything disputing its inclusion as an organelle. Also, it is consistent with the definition of an organelle: In cell biology, an organelle is a discrete structure of a cell having specialized functions. -- Serephine ♠ talk - 03:43, 19 December 2006 (UTC)
replies: text: I suppose they can be organelles :) It just sounds wrong to my mind though - like calling the spliceosome an organelle (nobody's tried to do that yet, have they?). Opabinia regalis 07:00, 19 December 2006 (UTC)
replies: text:  Heh heh you've caught me in a categorising mood so maybe I'll try ;) If it makes you feel any better, things like centrioles and ribosomes are included as organelles even though they have similarly non-membranous structures. -- Serephine ♠ talk - 07:21, 19 December 2006 (UTC)
replies: text: Centrioles? Ugh. Organelles are membrane-bound, dammit :) Opabinia regalis 01:59, 20 December 2006 (UTC)
thread_title:  Proteasome category question 

message: Should "ubiquitin proteasome pathway" be hyphenated (i.e., ubiquitin-proteasome pathway)? A quick Google search suggests so; I have also frequently seen it hyphenated in Portuguese. Fvasconcellos 15:04, 3 January 2007 (UTC)
replies: text: Missed this yesterday, but I think you're right. Also made ubiquitin-proteasome system et al. as redirects. Opabinia regalis 01:32, 5 January 2007 (UTC)
replies: text: Thank you. Fvasconcellos 17:39, 5 January 2007 (UTC)
thread_title:  Ubiquitin proteasome pathway 

message: Does anybody know something about him? He discovered it...  — Preceding unsigned comment added by 98.216.105.235 (talk) 03:13, 11 August 2011 (UTC)
thread_title:  Alfred Goldberg 

message: I added a little information on how there are different types of ubiquitin chains, and that only a subset of these chains will target proteins to the proteasome
Maximus155 (talk) 00:43, 3 February 2013 (UTC)
thread_title: Types of Ubiquitin Chains

message: A newer review article talks a lot about the E3 ligases. Not sure if its needs its own page or a least add some of the names mentioned in the article. The article can be found at http://www.ncbi.nlm.nih.gov/pubmed?term=the%20ubiquitin-proteasome%20system%3A%20central%20modifier%20of%20plant%20signalling BreCaitlin (talk) 01:36, 4 February 2013 (UTC)
thread_title:  E3 Ubiquitin Ligases 

message: I'm fairly new to using wikipedia, and until this article, I have not uploaded any images. However, there is a great image in a review article: http://www.ncbi.nlm.nih.gov/pubmed/23029643 that details the several types of proteasomes that exist. Although I realize that there is the potential for a copyright infringement, I uploaded the photo to Commons Wikipedia and inserted it into the article under "Role in the Immune System." Unfortunately, I did not know what copyright tag to use on the photo and so I put it as "fairuse" (which I know is not allowed). I did this hoping that someone would be able to clarify the issue and put the correct tag on it and/or delete it. However, since I found the article online (NCBI) and it is available to the public, I was assuming the copyright permission for redistribution was also allowed. Would someone be willing to respond and tell me what the criteria are for images in scholarly articles?
Also, if it turns out the image I did use is in violation of copyright law and must be removed, I still think that adding an image to show the several types of proteasomes and their components would be ideal. Therefore, maybe someone would be willing to create a diagram or cartoon of this? Thanks! MChapman5 (talk) 02:02, 4 February 2013 (UTC)
thread_title:  Types of Proteasomes 

message: There is new research  that shows that the immunoproteasome has another function outside of processing proteins for MHC I.  It demonstrates that the immunoproteasome also helps to prevent apoptosis during IFN-induced oxidative stress.  I want to include this information in this article, but I am not sure whether it should be included in the Apoptosis or Response to Cellular Stress section.  Gpruett2 (talk) 04:38, 4 February 2013 (UTC)
thread_title: Recently Discovered Function of Immunoproteasome

message: There are several references made the S26 Proteasome, but none of them out right say that they are only found in Eukaryotes.  I would like to add this in one place based upon the following reference The proteasome: molecular machinery and pathophysiological roles Tanaka K 2012   As I am a new Wikipedian I would like some feedback from more senior members.  — Preceding unsigned comment added by Hakkinen2013 (talk • contribs) 17:32, 4 February 2013 (UTC)
thread_title: S26 Proteasome Distinction

message: I propose that a section be added to explain some of the laboratory uses of ubiquitin.
For example, ubiquitin can be used to create an N-terminal fusion with your Protein of Interest (N-Ub-POI-C).
This fusion protein could be transformed/transfected into a cell for expression (plasmid: 5'-promoter-Shine/Dalgarno-(1)-Ubiquitin-ORF-3').
This would be done because an N-terminal ubiquitin fusion can augment yield of your protein of interest ("Butt et al. 1989. "Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli." Proc. Natl. Acad. Sci. USA. 86(8):2540-2544.)
The ubiquitin can then be cleaved from your protein of interest by any of a number of ubiquitin C-terminal hydrolases (Catherine A. Gilchrist, Douglas A. Gray and Rohan T. Baker. 1997. "A Ubiquitin-specific Protease That Efficiently Cleaves the Ubiquitin-Proline Bond." Journal of Biological Chemistry. 272(51):32280-5.)
 97.77.53.176 (talk) 02:47, 7 May 2013 (UTC)
thread_title: Uses of Ubiquitin

message: #Lead section is too short, doesn't nearly summarize key points of its contents;
#Chapter "Overview", second paragraph with no citation;
#Aaron Ciechanover, Avram Hershko and Irwin Rose receive 2004 Nobel Prize in Chemistry, but after mention it at "overview", it shouldn't immediately repeat at next chapter;
#Chapter "19S regulatory particle", second paragraph needs more citation; also with a lot sections need clear there sources, something like "Many bacteria also possess other homologs of the proteasome and an associated ATPase, most notably ClpP and ClpX. This redundancy explains why the HslUV system is not essential.""Lactacystin covalently modifies the amino-terminal threonine of catalytic β subunits of the proteasome, particularly the β5 subunit responsible for the proteasome's chymotrypsin-like activity. This discovery helped to establish the proteasome as a mechanistically novel class of protease: an amino-terminal threonine protease."--Jarodalien (talk) 14:13, 17 January 2016 (UTC)
thread_title:  Possible FAR 

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*Added archive https://web.archive.org/web/20130618053955/http://biochemie.web.med.uni-muenchen.de/feldmann/proteasome_units.html to http://biochemie.web.med.uni-muenchen.de/feldmann/proteasome_units.html
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thread_title:  External links modified 

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thread_title:  External links modified 

message: Proteasome in Sulfolobus:
* Evolutionary Insight: New Connection Discovered Between Primordial Organisms and Complex Life; on: SciTechDaily;  August 28, 2020; source: Lancaster University
* Gabriel Tarrason Risa, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, Dimitra Papatziamou, Delyan R. Mutavchiev, Catherine Fan, Leticia Meneguello, Andre Arashiro Pulschen, Gautam Dey, Siân Culley, Mairi Kilkenny, Diorge P. Souza, Luca Pellegrini, Robertus A. M. de Bruin, Ricardo Henriques, Ambrosius P. Snijders, Andela Šaric, Ann-Christin Lindås, Nicholas P. Robinson, Buzz Baum: “The proteasome controls ESCRT-III–mediated cell division in an archaeon”; In: Science;  7 August 2020; doi:10.1126/science.aaz2532
Is it worth to add to the article?
--Ernsts (talk) 16:05, 28 August 2020 (UTC)
thread_title:  Sulfolobus 

message: I am reviewing this article as part of WP:URFA/2020, an initiative to review older featured articles to ensure that they still meet the featured article criteria. I have some concerns that this article does not meet the criteria anymore, which I outline below:
*There are many uncited statements, and whole paragraphs without citations.
*The "Clinical significance" section, particularily the last paragraph, uses a lot of sources from the early 2000s that need to be updated with more current medical literature. This will ensure that the information here is accurate and include the most recent discoveries of the protein. 
*"Role in the immune system" could also be updated with more current literature, as the most recent source is from 2010. 
*Other sections could also do with a review to see if the medical literature still supports the statements in the article. 
Is anyone willing to undertake upgrading this article? I struggle with science topics so I can only help with jargon concerns at the end of the process. Z1720 (talk) 17:25, 17 July 2023 (UTC)
thread_title:  [[WP:URFA/2020]]