Talk:Dihydrocodeine

message: How potent is DF-118 when compared to codeine? Codeine article says about 10% of codeine is converted to morphine and this says that DF-118 is 30% potency of morphine. Does that mean that DF-118 is 3x as strong as codeine? —Preceding unsigned comment added by 139.30.17.38 (talk • contribs) 20:49, November 18, 2005
DHC is a more effective anlgesic than codeine for several reasons. From personal experience, it is more euphoric than codeine. Opioid analgesics work in part from their anxiolytic and reality detaching effects,(the psychic component of opioid analgesia). It has a much wider range of use in this respect, as its effective range from mild analgesic to euphoriant, is much wider. It is difficult to put into words, it just has a certain 'zing' to it codeine lacks (analgesically, and euphorically).
Also having ~3x > bioavailability (S.C,I.M,I.V) than codeine, it is even far more effective than codeine by injection, w/w.
It creates a strong dependency, but is a relatively functional opiate, even in large doses, cf.bupreorphine, morphine. It is not exceptionally sedating, in fact it can have a paradoxical stimulating effect.
I estimate it to be 1.5x stronger orally, and 3-4x by injection. Though you could not take inceased levels of codeine to acheive the same effect.Profmad (talk) 11:53, 21 November 2008 (UTC)
thread_title: Potency compared to codeine

message: The end of this article sounds like it was copy-pasted from Erowid or something. Somebody fix it.  —Preceding unsigned comment added by 72.69.86.183 (talk) 18:53, 20 March 2008 (UTC)
replies: text: I'm done with finals in a week, and after that I plan on deleting this whole section and fixing it. I understand someone's good intentions in providing info on safety with recreational use, but a lot of this information is guesswork, inaccurate, or just totally fabricated. The starting dose of hydrocodone in an opioid naive patient is between 5-10 mg, for moderate-severe pain. From my own experience, one Vicodin ES knocked me on my ass the first time I took it for wisdom tooth surgery pain. Another time, I took 17.5 mg of hydrocodone recreationally, and was so obliterated I couldn't type anymore. Another person may not even be affected by these doses. So suggesting doses for recreational use is not appropriate for WP, because recreational use of drugs is an inherently subjective thing, which shouldn't be brought into an objective environment. I'll be back.Ohnoitsthefuzz (talk) 07:28, 5 May 2008 (UTC)
thread_title: Recreational Use

message: The comparison made between DHC/Opioids and MDMA in this article is unfounded. Although most opioids do create a feeling contentment, well being and empathy, their method of action is totally different than MDMA, and comparing the empathy and euphoria of DHC to Heroin is another general statement that has little scientific background. I can see where the author is coming from, but he is basing his conclusions on personal experience, and lacks a knowledge on neurology, endorphins, dopamine and the serotonin system. I will try to fix this article in good time. --78.86.159.199 (talk) 23:20, 31 August 2008 (UTC)
thread_title: MDMA & Heroin

message: Added small note about availibilty in Australia, should I expand on this?
Didymal (talk) 10:20, 1 June 2009 (UTC)
thread_title: Adding something about availability in Australia

message: " First-generation antihistamines such as tripelennamine (Pyrabenzamine), clemastine (Tavist), hydroxyzine (Atarax), diphenhydramine (Benadryl), cyproheptadine (Periactin), brompheniramine (Dimetapp), chlorphenamine (Chlor-Trimeton), doxylamine (NyQuil) and phenyltoloxamine (Percogesic Original Formula) not only combat the histamine-driven side effects, but are analgesic-sparing (potentiating) in various degrees. The antihistamine promethazine (Phenergan) may also have a positive effect on hepatic metabolism of dihydrocodeine as it does with codeine. Higher doses of promethazine may interfere with most other opioids with the exception of the pethidine family (Demerol and the like) by this and/or other unknown mechanisms.
Other side effects include giddiness and a sense of hyperactivity. Many patients and experts have pointed out that many opiates have the effect of generating empathy and improving interpersonal skills in a manner analogous to, but subjectively different from, MDMA, MDA, and many related amphetamine-variant hallucinogens[citation needed][citation needed]. Dihydrocodeine and hydrocodone seem to have this effect somewhat in excess of their theoretical analgesic potency as compared to other opioids[citation needed][citation needed]. SS Bron and other formulations containg ephedrine or to a lesser extent dihydrocodeine analogues of the Tylenol With Codeine series with caffeine will intensify this effect;[citation needed] of course one can always take pure dihydrocodeine along with those ingredients, or other stimulants. Such mixtures are also superior in relieving many kinds of pain."
Surely this could be condensed to read "Antihistamines prleive the histamine mediated side effects of DHC, some may also potentiate its analgesic activity" and "adding caffeine to analgesics often enhances the pain releif afforded"
The stuff about MDMA and DHC being "more potent than it is" seems like gosip, rumor, suposition rather than proven fact.
Any comments?
It's also worth noting that MDMA is an empathogen, not a hallucinogen.   — Preceding unsigned comment added by 67.176.58.81 (talk) 02:26, 28 October 2011 (UTC)
thread_title:  Side Effects, potentiation, MDMA etc 

message: Dihydrocodeine certainly DOES have a dose-ceiling mediated by the CYP-2D6 enzymes O-demethylating it to dihydromorphine. The Ki data for DHC is very similar to that of codeine. This article seems to be geared towards the misuse of this material stating many facts without actual reference.  — Preceding unsigned comment added by 86.30.243.179 (talk) 14:12, 12 October 2011 (UTC)
thread_title: Dose Ceiling & style?