Talk:Cannabinoid receptor 1

message: Before I began editing, these pages were a jumbled mess of confused science and faux-science that had clearly been compiled by recreational marijuana users with minimal understand of how solid research is conducted or reported. Most of the sections were written independently and did not read cohesively when considered by page; as such much of my efforts were spent cleaning up the inconsistencies, miscitations, and straight up fallacies that littered each topic discussed. In addition, I added more citations from appropriate and current research and reorganized the pages so that they are presented in a more digestable format. 
	In summary, these pages on endocannabinoid receptors were not lacking attention before my edits, but had rather received too much attention from people who just did not know what they were talking about. I have simplified, clarified, and expounded where appropriate with the intention of creating a more cohesive and through product. The extent of these edits are subtle, but were based on eight research pages that I read dealing with the topics I addressed.  — Preceding unsigned comment added by Wyliea (talk • contribs) 01:45, 7 December 2011 (UTC)
thread_title: 12/6/2011 Edits

message: It should be made clear that the 'structure' shown for CB1 is only a 9 amino acid portion of one of the peptides of the full receptor. Unfortunately, there does not appear to be a full structure of the whole receptor on the PDB, but PDB ID 2KOE (Human cannabinoid receptor 1 - helix 7/8 peptide) might be an better choice until a complete structure is published.
--Bhbuehler (talk) 03:48, 6 June 2015 (UTC)
thread_title: Incomplete Protein Structure

message: Studies show CB1 mediated plasticity in Dorsal striatum, Amygdala, Prefrontal cortex, and Ventral tegmental area as well as the BNST, so this section can be updated.   Here is an review by Sidpura and Parsons on the topic  .  I just added a sentence.
OMM93 (talk) 05:12, 1 October 2015 (UTC)
thread_title:  Plasticity 

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thread_title:  External links modified 

message: No mention on the astroglial CB1 receptor? The articles bellow mention it as being associated with the working memory impairments.
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— Arthurfragoso (talk) 04:48, 19 January 2023 (UTC)
thread_title:  Astroglial CB1 receptor 

message: I could not find a direct statement saying Minocycline is a CB1 agonist. At least should not be on top. 103.160.128.19 (talk) 23:49, 9 December 2023 (UTC)
replies: text: Citation for the claim is this study https://academic.oup.com/cercor/article/25/1/35/365149 titled "CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice" by "Ana Belen Lopez-Rodriguez, Eleni Siopi, David P. Finn, Catherine Marchand-Leroux, Luis M. Garcia-Segura, Mehrnaz Jafarian-Tehrani, Maria-Paz Viveros" published in "Cerebral Cortex, Volume 25, Issue 1, January 2015, Pages 35–45".  https://academic.oup.com/cercor/article/25/1/35/365149 which would imply cannabinoid activity but agreed, this doesn't exactly mean it's an agonist Gettinglit (talk) 23:31, 12 December 2023 (UTC)
thread_title:  Minocycline in Agonists 

message: — Assignment last updated by Arianamarievasquez (talk) 04:13, 8 April 2024 (UTC)
thread_title: Wiki Education assignment: Psychology Capstone