Talk:Clonidine

message: Did anyone ever hear of very bad chest and back pain with this medicine?  Taking it four times a day, and my upper back and chest is killing me
Your side effect was probably a rare reaction.  The only side effect I experienced was being extremely tired at first.  
The most popular understated side effect of this medication is, for lack any milder way to put it, catastrophic loss of consciousness. Not so much "put them out like a light", but more like drop them like a punch from Mike Tyson, where they stand.   — Preceding unsigned comment added by 208.127.80.59 (talk) 11:57, 27 September 2011 (UTC)
thread_title:  Side-effects? 

message: This page is a candidate for cleanup. I propose that all of the benzodiazepines be wikified at once. The benzodiazepines are a significant family of drugs, and better information should be available here on Wikipedia, due to their widespread use.
: Clonidine is not a benzodiazepine.
You must be thinking of Klonopin (clonazepam).
[Speaking of which, does clonodine actually treat restless leg syndrome? or is that another klonopin accident? On the Restless legs syndrome wiki, clonidine is not mentioned...]  — Preceding unsigned comment added by 212.179.160.18 (talk) 08:05, 5 June 2018 (UTC)
replies: text: Clonidine can indeed be used in the treatment of RLS. I've cited this statement in the article to clarify the point. Thank you for the notification! ―Biochemistry🙴❤ 23:37, 3 October 2018 (UTC)
thread_title:  Cleanup 

message: Clonidine is often used to treat tics, specifically Tourettes Disorder, due to research by Dr. Richard Ferre, M.D. of University of Utah. I do not have a link to the specific paper, but you can find it on a Google search "Richard Ferre"
Yea, i have Tourettes and i take this. EvilHom3r 18:49, 6 August 2007 (UTC)
thread_title:  Creditation 

message: The muddle with clonazepam (Klonopin) here remains - for a start, one of the most common side effects of clonidine is insomnia (see the British National Formulary entry - probably same info listing in the Physicians Desk Ref too...) and I can hardly see it being rx'd for such. Indeed, its one of the drawbacks of using it for opiate withdrawal as the resultant insomnia can be severe and prolonged even after the acute symptons are over. In the UK, it is usually therefore prescribed for this purpose along with strong benzos such as Rohypnol or with benzo/chlorpromazine combinations to overcome this lack of efficacy. Anyway, someone ought to clear this up some more. If no-one better qualied tries, 'll come back and have a go. Plutonium27 (talk) 02:47, 5 June 2008 (UTC)
thread_title:  Clean-Up (again?) 

message: How is this drug a "α2 adrenergic agonist" AND "inhibits the release of norepinephrine (NE)". Can someone explain?  —Preceding unsigned comment added by 144.126.53.164 (talk) 11:51, 20 October 2009 (UTC)
thread_title:  Adrenergic Agonist AND NE antagonist? 

message: Clonodine is not Klonopin (clonazepam), it is not a benzodiazepine like (Valium, diazepam, Xanax, alprazolam, Ativan, lorazepam). etc... Clonidine is used alone or in combination with other medications to treat high blood pressure. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. It works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000623  —Preceding unsigned comment added by Jodiah (talk • contribs) 20:47, 29 June 2010 (UTC)
thread_title:  Clonodine 

message: I'm no expert, but do the two structure models agree? The 3D model shows both N atoms of the imidazoline ring with H's (implying imidazolidine), whereas the planar model shows N at position 2 with no H (imizazoline). The 3D model shows the N of the amine with no H and the planar model shows it with one.  —Preceding unsigned comment added by 220.244.145.200 (talk) 00:38, 8 December 2010 (UTC)
thread_title:  Structure 

message: There are two "Uses" paragraphs in the article.
Should be restructured.  — Preceding unsigned comment added by Vbond (talk • contribs) 06:25, 3 February 2011 (UTC)
thread_title:  Uses 

message: Clonidine is also given in conjuction with methedone/suboxone to combat excessive persperation. It is rarely given alone to combat the affects of opioid withdrawls. When combined with methedone/suboxone it has shown evidence of improving comfort levels when it comes to exessive persperation. The typical does when combine with methedone is 0.1-0.2 micrograms twice daily.  — Preceding unsigned comment added by 174.115.132.133 (talk) 20:07, 12 October 2011 (UTC)
replies: text: I don't believe that the article claims that clonidine is used as monotherapy for opioid withdrawal, so I don't really see the point of your comment. However, it is not unusual for clonidine to be used alone; opioid substitution therapy isn't necessarily always employed. ―Biochemistry🙴❤ 23:32, 3 October 2018 (UTC)
thread_title:  Clonidine in combination with Methedone or Suboxone 

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thread_title:  External links modified 

message: Does there exist any more-recent paper that supports the citation no.2 - Lowenthal, DT; Matzek, KM; MacGregor, TR (May 1988). "Clinical pharmacokinetics of clonidine.". Clinical Pharmacokinetics. 14 (5): 287–310. . doi:10.2165/00003088-198814050-00002 ?  Thanks! : )  --It's gonna be awesome!✎Talk♬ 16:32, 8 September 2017 (UTC)
thread_title:  Citation update  

message: User:Sbelknap what are your thoughts on this diff? Jytdog (talk) 13:42, 8 August 2018 (UTC)
replies: text: Fixed. Interesting, as there seems to be an error in this low-quality article, so I've removed the citation. The best citation is the Goodman and Gilman one on page 202 of the 13th edition. Its post-synaptic alpha 2 agonism in vascular smooth muscle that gives the transient rise in blood pressure. I notice that John Reid mentions both mechanisms in his articleB. J. clin. Pharmac. (1981), 12, 295-302 THE FOURTH LILLY PRIZE LECTURE, UNIVERSITY OF ABERDEEN, SEPTEMBER 1980 THECLINICALPHARMACOLOGYOFCLONIDINEAND RELATED CENTRAL ANTIHYPERTENSIVE AGENTS JOHN L.REID DepartmentofMateriaMedica, UniversityofGlasgow,Glasgow,Scotland, citing Doxey et al for the alpha 1 mechanism DOXEY, J.C. (1979). Pre and postsynaptic effect of alpha agonists in the anococcygeus muscle of the pithed rat. Eur.J.Pharmac.,54,185-189. and citing Drew and Whiting DREW, G.M. & WHITING, S.B. (1979). Evidence for two distinct types of postsynaptic a-adrenoceptors in vascular smooth muscle in vivo. Br. J. Pharmac., 67, 207-215. for the post-synaptic alpha 2 mechanism. I'll ask Tom Westfall, who wrote the Goodman and Gilman chapter, what he thinks. Sbelknap (talk) 18:12, 11 August 2018 (UTC)
thread_title:  Which receptor? 

message: Stick and ball strucutural formula shows the bridging Nitrogen without a Hydrogen.  It shows both ring Nitrogens with a Hydrogen.
Letter structural formula shows bridge Nitrogen with a Hydrogen and one of the ring Nitrogens without a Hydrogen.
The following, currently reference 1, puts the Hydrogen on the bridging Nitrogen.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7f569dc-6bed-42dc-9bec-940a9e6b090d
2600:387:B:9A2:0:0:0:9 (talk) 08:46, 3 August 2021 (UTC)
thread_title:  Conflicting structural formulae 

message: , you keep changing the "alpha-2 agonist" to "alpha-2a agonist". The issue is the body doesn't support the selectivity for 2a (as it does in the guanfacine article). If you want to keep changing it to alpha-2a, please provide a source that supports clonidine being more selective for alpha-2a than the others.
Kimen8 (talk) 13:33, 22 November 2023 (UTC)
replies: text: My apologies, it does indicate alpha-2a selectivity. Kimen8 (talk) 15:24, 24 November 2023 (UTC)
thread_title:  Selectivity