Talk:Buspirone

message: The buspirone page and much of the talk about it is anecdotal, personal, and include many passages with
non-grammatical words that undermine the apparent intent.  It does not appear to have been written by a person or
persons with medical training and clinical experience, often sounding more like the experiences of someone who has
tried BuSpar at a rave.  I object to the use of personal experience in what is should be an objective compendium.
Statements are made that betray a lack of understanding of GAD and what constitutes effectiveness in pharmacologic
treatment.  I would gladly contribute to this work when I have the time to provide thorough analyses.  I have been
treating patients with buspirone since its US release and will attempt to bring balance to this important section
of the Wikipedia.  One area is in the discussion of grapefruit juice.  Only juices of certain fruit have an
appreciable effect and, even then, only in larger volume than most people consume.  More importantly, using daily
dosages as high as 90 mg/day, and treating hundreds of patients with this medication, I have yet to meet a patient
who describes euphoria resulting from buspirone.  I've also never known a patient to "mix" buspirone in any liquid.
If "Resulting so would be in euphoria" is an accurate quote, nothing is gained by using it since it doesn't make
sense.  Mark Henigan (talk) 08:30, 2 July 2010 (UTC)
thread_title: Untitled

message: = http://www.nature.com/clpt/journal/v64/n6/abs/clpt1998166a.html
Wikipedia hasn't got more user-friendly during the last years; how can one edit this new link under point 5 ??!
190.10.21.230 (talk) 08:07, 13 September 2009 (UTC)
thread_title: Grapefruit juice substantially increases plasma concentrations of buspirone'

message: I have moderate GAD. I started taking Buspar 2.5 years ago. I am amazed at how well this drug works. It makes me dizzy about 30 minutes after I take it. The feeling lasts only for about an hour. I get very sleepy from the drug. I take my first dose early in the morning and fall back to sleep. I take my second dose before I fall asleep in the night. Thank the good Lord that this drug works!
buspar didnt make me sleepy and really hasn't done anything with by general anxiety disorder. i also take zoloft but nothing seems to help. Can someone relate.
I just started taking Buspar today.  I also take Cymbalta and Clonazepam, both at max dosage levels and still have anxiety problems. The psychiatrist told me that the Buspar can help to increase the effectiveness of the other anxiety and depression meds I am on as well as provide some extra kick.  Remember everyone, I have been through the worst and back with this disease, it is a constant excercise in trial and error to find the right mix of medications that work for you.  Keep trying, and keep talking to your doctor.  Constantly reporting changes in your symptoms really helps the doctor and increases your chances of finding the right combination of drugs for your condition.
I have been taking Buspar for one month. It has not helped my general anxiety as I had hoped, if at all, but I like it for other reasons. 1) it helps with social anxiety. I tend to be shy and get anxious in social situations and now this is not as much as a problem for me. 2) it gives me an energy boost each day. I am more productive at work and less tired. Sometimes it causes me to be too hyper and manic and I can't get to sleep and am bouncing off the walls, but this is improving with time. It certainly does not cause me to be sleepy or sedated. 3) it helps me stick on task and get projects done I was formerly unable to. It seems to increase my ability to concentrate. 4) it seems to improve/lighten my mood. 5) it enhances my senses of smell and taste. This is decreasing with time on the drug, but the first week, this was very pronounced and I really liked it. Now I experience this usually just within the first hour or so of a dose. 6) it seems to enhance my pleasure when doing things that are normally pleasurable. Now they are more so. 7) in the first few days on the drug, I became a very reckless driver. Completely unlike me. So beware. Now this effect is gone. Overall, with time, a number of these effects are decreasing. The main ones that remain for me are decreased social anxiety, increased energy, and lightening of mood.
This paragraph is from another user.  I found this drug worked immediately and very well for anxiety, but in me it also produced profound insomnia (I did not sleep for 48 hours) and so I discontinued it pretty quickly.  It also enhanced my sense of smell, which I enjoyed.  Although I was unable to continue with the drug, I think it gets an undeserved bad rap as "useless for anxiety" - that was definitely not my experience.  24.58.172.158 (talk) 02:55, 7 January 2008 (UTC)
replies: text: Buspar is not chemically similar to Xanax. Utaninja (talk) 09:32, 28 November 2023 (UTC)
thread_title:  Buspar 

message: it may be misleading to compare this drug to valium or any other benzo.  it obviously does not function in the same way, since dependency would result if it did.  thus the experience induced by buspirone is going to differ from that of valium.  perhaps this is why there is no citation for the comparison.
(i have a lot of experience with both substances and other anti-anxiety drugs). —The preceding unsigned comment was added by Harlequence (talk • contribs) 06:17, 17 January 2007 (UTC)
thread_title:  comparison to diazepam 

message: "Its sales have been on the decline in recent years due to its unpleasant side effects."
This claim sounds strange to me. Other sources consider it to be a drug with exceptionally low side effects!
Are sales really declining? If so, what are the reasons? Ineffectiveness? lack of incentive to promote it because of patent expiration? Definitely !
: For the record I've just been informed that Buspirone has been discontinued here in Australia. 121.91.167.195 (talk) 13:00, 24 May 2013 (UTC)
thread_title:  Decline? 

message: :Image:BusparAd.png is being used on this article. I notice the image page specifies that the image is being used under fair use but there is no explanation or rationale as to why its use in this Wikipedia article constitutes fair use. In addition to the boilerplate fair use template, you must also write out on the image description page a specific explanation or rationale for why using this image in each article is consistent with fair use.
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BetacommandBot 06:56, 27 October 2007 (UTC)
thread_title: Fair use rationale for Image:BusparAd.png

message: Paresthesia is listed under side-effects, but not "brain zaps," which is similar but clinically different. I know from personal experience that the so-called brain zaps are definitely a side-effect of taking Buspar. Would anyone object to adding "brain zaps" in parentheses following paresthesia in the list of side-effects? Svadhisthana (talk) 18:36, 28 January 2008 (UTC)
thread_title:  "Brain zaps" 

message: It goes on and on how safe and non-addictive it is, and how well it will 'replace' benzodiazepines. It then goes on to bash benzodiazepines(probably fueled by the current public hysteria about them) and proposes that people take buspirone instead(of course).
1. Buspirone is completely unrelated to benzodiapines. It modulates serotonin receptors while benzos modulate GABA receptors. It's like comparing a bicycle to a Mercedes and claim it can replace it easily. In most circumstances, it cannot.
2. Because a medication inevitably produces physical dependence does not mean it should not be prescribed. If that was the case, we would have to stop all prescriptions for insulin because once insulin is administrated, the body becomes insensitive to it, lowers its own production and the patient becomes effectively dependent on it for life. Should we force all diabetics to go 'Cold turkey'? No, it just means the patient must be informed that he/she will become dependent on it and will have to go through a tapering process in order to stop it.
3. There is a major hysteria epidemic going on about benzodiapines, probably as a result of the street popularity they have had for so many years. They are popular with almost any illegal drug user and fetch a moderate price. But does that mean that people with GAD and other diagnoses should be forced to give them up just because some on the street are using them to get stoned?
4. It seems like the current trend is to replace effective drugs with potential for abuse, with less effective drugs with no potential for abuse even if it makes people suffer. Is that progress? We started with barbiturates, then went to potent benzodiapines, then mixed agonist benzodiapines, now it's reduced to feeble serotonin modulators. If the reverse progress continues, the next popular medication prescribed will be a glass of water! Completely free of abuse potential and side effects!
The fact is, buspirone is a petty drug with minor effect, best prescribed as an add-on to another more effective drug. The reason is has not shown potential for physical dependence is probably because the effect both weak and slow. But the industry is pushing it because it's expensive (WTF?  $4 for 60, 10 mg tablets is not expensive, it is a cheap generic now), the doctors are pushing it because takes responsability off their back and the patients just has to live with less and less effective drugs. Welcome to the new century of progress! (FYI I don't take any benzodiazepines myself, I don't have problems with GAD either) -M99 87.59.78.70 (talk)  —Preceding undated comment added 16:12, 12 July 2009 (UTC)
thread_title:  This article is written like an advertisement 

message: I highly doubt it, it depends on the weight of a person. Ive drank beers 2 hours after taking it , Not healthy but it did not interact with me.
Currently looking for sourcing on this. JasonHockeyGuy (talk) 09:25, 27 February 2010 (UTC)
thread_title:  Section on Alcohol interaction 

message: Is this true? I have found no other reference to buspirone interactions with kool-aid.  —Preceding unsigned comment added by Diplodicus1812 (talk • contribs) 02:57, 1 December 2010 (UTC)
replies: text: Probably not, I changed it.--Literaturegeek | T@1k? 05:03, 7 December 2010 (UTC)
thread_title:  buspirone vs kool-aid? 

message: Why is there no section on side effects?  —Preceding unsigned comment added by 98.213.10.57 (talk) 03:02, 22 February 2011 (UTC)
thread_title:  Side effects 

message: This article, as are many other 'scientific' articles in wikipedia has a lot of erroneous research reports that have clear bias intent in the mechanism section.
The use of questionable research publications- Indian publications that are not Internationally well known, the lack of meta-analysis that has been peer reviewed, and citations of minutes from meetings and or use of lay websites is an inappropriate attempt to explain the scientific mechanisms of a drug.  All of these were being used until I was forced to delete them.  It is not appropriate at all.  
Reading them, it was clear that someone had included these citations through simple internet searches with no scientific background or in the case of the Indian publications had suspicious links to the articles themselves- ie were from India and published them etc.  Many of these citations were from obscure journals that had no basis for being included in a general page that clearly does not discuss every single research paper out there about the drug.  Why were those specific facts (facts that have not been agreed upon entirely) included? Why were others excluded? Until this can be clarified such medical information has no place when the research can be questionable. 
Please refrain from posting erroneous or poorly cited works when discussing medical information. 
I am a MS 4 Medical student with extensive history in neuroscientific research (BS Neuroscience, 2 years published history, Medical student, future neurologist).  — Preceding unsigned comment added by Jay238 (talk • contribs) 15:25, 12 July 2014 (UTC)
replies: text: You are correct.  Per WP:MEDRS, any medical claims must be supported by reliable secondary sources. Thanks for removing the questionable text that is only supported by primary sources. Cheers. Boghog (talk) 19:29, 12 July 2014 (UTC)

text: That is the best argument you could possibly make for excluding this stuff. Wikipedia is an encyclopaedia, a tertiary source. We include what reliable independent sources say, and that does not include listing work-in-progress because in drug research the facts show that work in progress usually comes to nothing. Oh, and there are charlatans promoting off-label uses of drugs which are entirely unsupported by valid research, so there's that too. Thus, we wait for MEDRS. Guy (Help!) 21:04, 10 April 2016 (UTC)
thread_title:  Inappropriate use of citations and research 

message: As of 8/27/2014, this article does not appear to be any more technical than any other page about a pharmaceutical, and it is fairly easy to understand. It would be a mistake to further dumb it down. Oceanlab (talk) 16:33, 27 August 2014 (UTC)
replies: text: I concur.  IMHO it appears to be better written and better cited than many of its "to and from" links(explains the 'B' class).  And, it appears to be technically on par with its "to and from"s.  I'm removing the tag. --:- ) Don 00:53, 18 September 2014 (UTC)
thread_title:  Article Too Technical  

message: I am a 60 year old man that has been in Paxcil for some 20 years now. I am seeing a different MD that has suggested that I consider changing to a new med called "Buspirone". He has asked me to also consider , "Bupropion, Quetiapine, and Aripipinzole".(not sure if I spelled it right) That this stage of the game I'm not sure that these med's are better or not. The paxcil seems to be taking care of my anxiety's quite well, but my depression seems to still be apparent to my Dr. and some times to me also. So, if anyone would like to chime in as to these different med's,  please do. Thanks. 68.199.0.67 (talk) 18:40, 10 January 2015 (UTC)
thread_title:  Paxcil (peroxitin) vs. Buspirone 

message: All sources cited under "Adverse effects" show Premature ejaculation as rare or they dont mention it at all https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-03962-3&d=2015052516114622412 http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a3fe0ccd-565f-4d0a-a7ba-2fad7a819358  — Preceding unsigned comment added by 71.58.178.138 (talk) 19:23, 25 May 2015 (UTC)
thread_title:  Premature ejaculation not common 

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thread_title:  External links modified 

message: This article states it doesn't have the risk of withdrawal like other drugs of it's nature, but I, and many many others, strongly beg to differ. Everyone I've spoken to who, came off it, had the same withdrawal symptoms of extreme anxiety, panic attacks, and some issues like I am suffering akathisia. It lasts for months, I just got through the second month of this hell. I've never had a panic attack in my life until this withdrawal. I never had akathisia so bad I can't sleep at night. This is all, absolutely, the withdrawal, and it's a living nightmare. 108.83.177.138 (talk) 17:31, 20 March 2017 (UTC)
thread_title:  Withdrawal 

message: I wrote about the interaction with cannabis. 
It was a mistake. I was supposed to write that under a different medication. I accidentally opened the wrong tab, on my browser, and wrote it here. 
Please remove it, thank you. 2001:56A:F9D7:BD00:ADBC:ACC7:9824:1DC4 (talk) 02:58, 19 November 2022 (UTC)
replies: text: I removed the other section for you. Though you can remove your own comment by clicking undo in the page history (if your edit is the latest version of the page). Tropicalkitty (talk) 03:21, 19 November 2022 (UTC)
thread_title:  I mistakenly added a topic, to this. Please remove it. 

message: , in this edit you changed the wording to say it is currently sold under the name Buspar, and removed the part saying it is marked as discontinued by the FDA. This doesn't seem to be accurate: the FDA still lists Buspar as discontinued from what I can see, and as such it is not most commonly sold under the name Buspar. Can you provide some source for your change? Kimen8 (talk) 22:09, 19 December 2023 (UTC)
thread_title:  Buspar discontinued