Talk:Cholinesterase

message: Concerning merge from acetylcholinesterase: I consciously merged the articles in the reverse direction because acetylcholinesterase is fully dealt with on this page. Moreover, as the current page mentions there are two enzymes referred to as cholinesterase. It would thus be erroneous or misleading at least to redirect cholinesterase to the other article. Notice I left the stub status there.
--Phils 17:05, 18 Oct 2004 (UTC)
thread_title: Comment not originally with section title

message: Removed here, if someone could find the documents in question without page forwarding links, it'd be awesome. Otherwise will do later hopefully.
*Study showing magnolia oil as an acetylcholinesterase inhibitor.
*Cholinesterase inhibitors might alleviate methamphetamine-induced delusions, hallucinations and cognitive impairment, while reducing craving and addiction
  —The preceding unsigned comment was added by Tom Meakin (talk • contribs) 09:54, 31 January 2007 (UTC)
thread_title:  External links broken 

message: Revision as of 06:38, 22 August 2005 by 211.30.120.226 stated that
<Blockquote>Cholinesterase inhibitors were discovered by Professor Cardillo of Sydney University, Australia.</Blockquote>
On August 23rd 2005, User:Jfdwolff removed that part and commented:
<Blockquote>Strychnine has been around for much longer</Blockquote>
Although I'm unable to confirm the first statement, I know for sure that the counterargument doesn't stand. Even though the manifestations of a strychnine poisoning resemble that of a cholinesterase inhibitor massive overdose in that both may produce myoclonic or tetanic convulsion, strychnine is not a cholinesterase inhibitor.
Strychnine works by blocking the release of glycine from inhibitory interneurons in the spinal cord. This increases reflex excitability and result in convulsion.
Ref: Rang HP, Dale MM, Ritter JM. Pharmacology 
If someone can ascertain that a Professor Cardillo did discover cholinesterase inhibitor, please add it to the text and state your source.
Benoitduhaime 05:24, 9 October 2005 (UTC)
thread_title:  Cholinesterase inhibitor discoverer 

message: Please do not assign a EC number, examplified in the article, to a class of the enzymes
O...F..F...I...C...I...A...L
definition of EC number...???
--222.64.223.233 (talk) 07:15, 30 July 2009 (UTC)
thread_title:  Confusing topic.... 

message: it seems as though the question of WHY organophosphates inhibit this enzyme is skimmed, skipped, or glossed over (probably intentionally so)... It seems as though no authors are willing to say something as clear cut as:  "the organophosphate inhibitors structurally resemble the activated tetrahedral transition state of enzyme bound acetylcholine, and inclusion of a leaving group that is labile upon reaction of the phosphorous center with the the serine residue results in an irreversibly deactivated enzyme" I have brought this up because this specific example is often used in introductory upper division biochemistry courses to help teach students about host-guest macromolecular chemistry, common enzymatic mechanisms (carbonyl-->tetrahedral Tstate stabilized by His residues for example), etc...   Yet I see no mention of this, even with a big "warning" or "disclaimer" that says:  "this information is not general, and not all classes of inhibitors function in this way"68.6.76.31 (talk) 21:09, 9 February 2011 (UTC)
thread_title: Question Relating to All Topics Related to Acetylcholinesterase

message: The discussion of cholinesterase in pop culture is pretty worthless. Who cares if the word was used in a song title or some random TV show? It's not noteworthy.  — Preceding unsigned comment added by 108.100.181.40 (talk) 16:48, 6 January 2017 (UTC)
thread_title:  Pop culture is silly 

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thread_title:  External links modified 

message: This article: 
The main type for that purpose is acetylcholinesterase (also called choline esterase I or erythrocyte cholinesterase)
Acetylcholinesterase article: 
Acetylcholinesterase (HGNC symbol ACHE), also known as AChE or acetylhydrolase, ...
Biologist, this is chemist. Chemist, this is biologist. From now on, please nod politely as you pass each other in the corridors. — MaxEnt 19:32, 17 March 2018 (UTC)
thread_title:  Other names 

message: Extension.
:User Tom Meakin, - added and improved. "...
Cholinesterase inhibitors may alleviate delusions, hallucinations, and cognitive impairment caused by methamphetamine while reducing cravings and dependence...” In 2007.
      :Symptoms of drug-induced reduction in A.Ch.E. ???
       :Known: nausea, vomiting, diarrhea (diarrhea). Further: drowsiness, sleep (unconsciousness), coma, death.
:Laboratory levels of A.H.E. in blood. Level... A.H.E. , - into symptoms???
      :At what level of A.H.E. , -  nausea? Level
  : A.H.E. , - diarrhea? At what level - unconsciousness and coma?ElvisorNr2 (talk) 11:15, 11 October 2023 (UTC)
thread_title:  Using A.H..E. inhibitors. In medicine, social medicine.