Talk:Xylazine

message: Hello fellow Wikipedians,
I have just modified  on Xylazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added  tag to http://www.omafra.gov.on.ca/english/livestock/horses/facts/00-063.html.
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Cheers.—InternetArchiveBot (Report bug) 17:31, 13 July 2016 (UTC)
replies: text: Fixed link in article. DferDaisy (talk) 02:41, 31 January 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified  on Xylazine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive http://web.archive.org/web/20150407160416/http://www.merckmanuals.com:80/404.html to http://www.merckmanuals.com/404.html
*Added archive http://web.archive.org/web/20070302155131/http://www.rompun.com:80/ to http://www.rompun.com/.
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thread_title:  External links modified 

message: I was interested in learning more about the following claim from the article: 
 
Xylazine has varying affinities for cholinergic, serotonergic, dopaminergic, α1 adrenergic, H2-histaminergic and opiate receptors.[4]
 
Unfortunately I wasn't able to verify this from the citation. It seems the claim has been repeated almost verbatim in a series of papers, all ultimately relying on a source from 1982 which I was unable to locate.
 
The wiki citation (Ruiz-Colón et al, 2014) mentions these receptors only once in the introduction:
 
Its actions may also involve cholinergic, serotonergic, dopaminergic, α-1-adrenergic, histaminergic, or opiate mechanisms [3].
 
The citation here is Hoffmann et al, 2001 which almost identically states:
 
Xylazine actions may also involve cholinergic, serotonergic, dopaminergic, α1-adrenergic, histaminergic, or opiate mechanisms (12).
 
Which leads to the citation I wasn't able to find:
 
J.V. Kitzman, N.H. Booth, and R.C. Hatch. Antagonism of xylazine sedation by 4-aminopyridine and yohimbine in cattle. Am. J. Vet. Res. 43:2165-2169 (1982)
 
 
I also searched pubchem which has 2,275 bioassays for xylazine. Despite this I found only:
* Inactive at Serotonin 1A, 2A, 5A
* Inactive at Dopamine D1, D2, D3
* Inactive at α1 adrenergic
No conclusion can be drawn about the original claim's veracity, but given the context and general lack of information I wonder if:
* The primary source may have demonstrated partial reversal of xylazine's effects, and speculated that the remaining effects are due to an unknown mechanism (perhaps cholinergic, serotonergic, dopaminergic, etc).
* This was misquoted by a citing author as evidence of a secondary mechanism, and this misquote was cited by all subsequent papers.
::There is also repetitive language, and childish usage in the "quotes" that makes this part of the article a load of nonsense.  — Preceding unsigned comment added by 2600:1700:6AE5:2510:0:0:0:24 (talk) 01:33, 11 September 2023 (UTC)
replies: text: Since it's been over a year now I went ahead and removed this line from the article. I'd still be interested if anyone has access to the 1982 Kitzman et al paper. Jamedeus (talk) 00:09, 3 February 2024 (UTC)
thread_title:  Unreliable citation in Pharmacodynamics? 

message: Ref name=Xiao is to an animal study, strictly confined to monkeys, of hyperglycemia following xylazine injection. Other properties, uses and side effects are mentioned, but this paper is not itself a review of the drug in general, or a review of human use. Xylazine in street drugs is much in the news currently, so most users reading this article are likely interested in human (ab)use, rather than legitimate veterinary usage. This cite should be replaced in most cases by a more appropriate one, or state clearly that it is only an animal study.
There are half a dozen references to this source scattered through the article; the first cite is in section History just after the lead and explicitly ties it to humans, so that one definitely needs to be fixed. It looks a bit complicated to review them all, find a better reference, and redact. I will do the clean-up if another editor doesn't jump in first, but I'll have to postpone it. D Anthony Patriarche (talk) 16:15, 31 March 2023 (UTC)
thread_title:  Inappropriate reference to animal study  

message: Two things I'd like to address:
Firstly, it is important that everyone who views this article knows about the issue of xylazine's use as a recreational drug—both on its own or in combination with fentanyl, but especially with the latter in the USA. The seriousness of this issue cannot be understated. Thus, I strongly believe that the second paragraph in the top section of the page should be swapped with the third. Furthermore, a short and concise description of xylazine's use as a fentanyl augmentation should be mentioned at the beginning of that paragraph. 
Secondly, use of the term "tranq" has become cloudy among both users and health professionals, just as many slang terms for drugs tend to do. The term can mean a number of things, but in the USA it generally refers to any fentanyl that has been mixed with either xylazine or novel benzodiazepines, or occasionally both. Unlike in Puerto Rico many years ago, xylazine is very rarely used on its own in the USA, and this should also be made clear to the reader (again, in a concise manner). 
Finally, the NIH / PubMed paper cited about xylazine abuse in Puerto Rico was published more than twelve years ago, therefore it's my belief that the focus of the header paragraphs should be on the basics of the drug itself and its current use as a combination drug with fentanyl, now known as "tranq" (among other names). Normally I'd simply edit the article myself, but this one is written very well—as many scientific, medical, etc. articles tend to be—so I thought it would be nice to talk about it first.  Bveracka (talk) 11:32, 14 June 2023 (UTC)
thread_title:  Suggestion and Offer to Edit Important Info 

message: As a veterinary clinician, it's extremely pertinent that you carry yohimbine with you if you are to administer xylazine in any capacity for the sole reason that it rapidly reverses sedation in the event of accidental administration. In much the same way naloxone is to be carried with etorphine, you can never be sure that you won't accidentally jab yourself when dealing with large, unpredictable animals, and so bring a specific antidote at all times. Much is this article is hysteria ridden with way over the top descriptions (Ranitidine, aka Zantac, as part of treatments used?) and is far too informed by its newly designated status as a drug of concern while being under-informed on the true place and usage of such drugs. I'll work on it here and there, but this page has multiplied since I read it first about 10 years ago, with some information being a great addition (ex. it's testing in the 60's for humans, and subsequent rejection due to bradycardia, which I had to find on my own back then), and some being I'm sure well meaning, but detrimental to it's adequate widespread understanding. Additivefreesb (talk) 19:53, 28 July 2023 (UTC)
thread_title:  Xylazine does have a specific antidote..