Talk:Aminoglycoside

message: azithromycin — what about it? it's a macrolide.
:then it doesn't belong here then does it? 90.207.35.126 (talk) 20:43, 23 February 2008 (UTC)
thread_title: azithromycin question

message: Is the preferred form with a capital or with a lower case letter?  30S or 50s   Thanks.  Mseliw 12:10, 12 June 2007 (UTC)
replies: text: Should be with a capital 'S' for Svedberg, the non-SI unit of ultracentrifugation. -- MarcoTolo 00:58, 13 June 2007 (UTC)
thread_title: ribosomal subunit

message: is this vandalism, or am I missing something? Juhan RSA (talk) 14:26, 23 February 2011 (UTC)
replies: text: Actually no (surprising as it may seem). It provides some references in the section, and I found this article that talks about the use of Aminoglycosides for treatment of genetic diseases. --Wertyu739 (talk) 22:40, 7 May 2014 (UTC)
thread_title: Nonsense suppression

message: Ref. #9 (Pharmamotion by Flavio Guzman) leads to a blog in Spanish with no information on aminoglycoside mode of action. It should be substituted.  — Preceding unsigned comment added by Fassbinder69 (talk • contribs) 12:56, 25 June 2012 (UTC)
replies: text: I have begun this substitution.  Apart from the Spanish language issue (with all due respect to Dr Guzman), it is not an appropriate published, peer-reviewed secondary or primary scientific source. Leprof 7272 (talk) 14:40, 22 February 2014 (UTC)
thread_title:  References to be updated 

message: It would be nice to have all the aminoglycosides drawn the same way, currently various types of representation are used, and different orientations are shown, making comparisons difficult. I'm new here so I don't want to step on any toes, but I do have the ability to make a standard set of aminoglycoside images, if it's appropriate. I suppose I'll look into figuring out how the whole wikimedia business goes and figure out how to go through the proper channels. Scaldwell17 (talk) 07:12, 18 December 2013 (UTC)
replies: text: Concur. The chair seems to be the prevalent form presented, and so I will look to see if some "uniformization" can be done, short of beginning a completely new structure drawing effort.  If another editor is ChemDraw savvy and wishes to create new images, I would be glad to be the structure checker/verifier.  Start from the Evans-Harvard ChemDraw template, please, so that over time the images begin to coverage on a common format. Leprof 7272 (talk) 14:40, 22 February 2014 (UTC)
thread_title: Standard Image Format?

message: In re-ordering the images in the gallery according to sub-class, the following images—which do not appear in the cited Mingeot-Leclercq et al. review—were pulled temporarily, until a citation merging them with the Mingeot-Leclercq list can be found. (I.e., that list, because dated, may not contain all relevant examples, but until a newer/better citation is identified, we have no source assigning these as aminoglycosides, nor can we assign subclass (without doing "original research").
 File:Framycetin.png|Framycetin
 File:Bekanamycin.png|Bekanamycin
 File:Hygromycin b.svg|Hygromycin B
 File:Verdamicin.svg|Verdamicin
 File:Astromicin.png|Astromicin
 File:Spectinomycin.svg|Spectinomycin
Note, spectinomycin is arguably a distinct structural class.  Leprof 7272 (talk) 14:47, 22 February 2014 (UTC)
thread_title:  Temporary removal of some images from gallery... 

message: These non-mechanistic paragraphs are largely unreferenced, and by parsing them according to subject, venues are created that should allow subject matter experts to address the areas that they know best.  Cheers.  Leprof 7272 (talk) 19:18, 22 February 2014 (UTC)
thread_title:  Created subheadings for non-mechanism paragraphs in earlier mechanism section. 

message: Though not perfect, I have completed today's redraft of the mechanism section.  As noted above, non-mechanistic text was separated out into separate subsections, and these remain problematic—they lack citations, have material redundant with other parts of the article (compare Indications with Clinical), and are generally lower in quality of material. (The PK and PD sub-section is particularly unready for encyclopedia readers.)  Note that while the three bullet point structure of the earlier version is gone, the ideas have been integrated. All three points still appear, though with different (unequal weights) as befits presentation of this mechanistic topic by the best sources. Note, in particular, that the "movement of the peptidyl-tRNA from the A- to the P-site" point still appears, despite it having no support in a reliable citation.
The only real redaction—apart from the two paragraphs noted, and appearing above—is the citation:
* ref name=Flavio>Pharmacology Corner --> Protein synthesis inhibitors: aminoglycosides mechanism of action animation. Classification of agents Posted by Flavio Guzmán on 12/08/08
which has appeared with a "self-published" query for three years.  This is a personal set of web pages (with all due respect to Dr Guzmán), and so is not an appropriate repeat source for this article's topic. (See addition editor's questioning of this source, above.)  
So, this section is now ready for some further "heavy hitting" by some other subject matter experts. Please, please, please expert editors—replace the sections of unreliable, unsourced text, with appropriate text worthy of a good article in a good online encyclopedia.  Cheers.  LeProf  Leprof 7272 (talk) 20:42, 22 February 2014 (UTC)
thread_title:  Re-draft of mechanism section complete. 

message: …so that all appearing structures have same chair-boat representation, so that readers do not have to have significant organic chemical expertise to view and compare drawings. (The chair-boat appears to have been settled upon earlier as the standard in this article; the majority of readily available images of aminoglycosides are in chair-boat, rather than line-angle representations, and so this makes sense.)
This image-removal-to-Talk is a stop-gap measure, until a better overall composite image for the various amino glycosides can be designed. (There is mention of such in a Talk section entitled Image Gallery above, that gives a citation to a good amino glycoside figure, and this citation is re-appended here, after the three structures that are being temporarily removed.) 
Note, I searched the German and English wikipedia articles for better images of all of these amino glycosides, and those appearing are the best, most consistent images that could be identified.
Temporarily removed images:
File:Arbekacin.png|Arbekacin
File:Ribostamycin.svg|Ribostamycin
File:Isepamicin.svg|Isepamicin
Good image structure example, with good use of space and good structure conventions:
:M-P Mingeot-Leclercq, Y Glupczynski & PM Tulkens, 1999, Aminoglycosides: Activity and Resistance, Antimicrob. Agents Chemother. 43(4) 727-737.
173.15.74.18 (talk) 16:15, 20 March 2014 (UTC)
thread_title:  Three structures removed to make gallery consistent in format... 

message: Hello fellow Wikipedians,
I have just modified  on Aminoglycoside. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20140301061340/http://www.merckmanuals.com/vet/pharmacology/antibacterial_agents/aminoglycosides.html to http://www.merckmanuals.com/vet/pharmacology/antibacterial_agents/aminoglycosides.html
*Added archive https://web.archive.org/web/20140301061340/http://www.merckmanuals.com/vet/pharmacology/antibacterial_agents/aminoglycosides.html to http://www.merckmanuals.com/vet/pharmacology/antibacterial_agents/aminoglycosides.html
*Added archive https://web.archive.org/web/20070208021556/http://www.nlm.nih.gov:80/medlineplus/druginfo/uspdi/202027.html to https://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202027.html
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—InternetArchiveBot (Report bug) 18:05, 11 October 2016 (UTC)
thread_title:  External links modified