Talk:Catechol-O-methyltransferase

message: Would it not be better to replace Cartoon with either Ribbon OR Richardson diagram and a link to the Wiki Page: https://en.wikipedia.org/wiki/Ribbon_diagram
Not sure how relevant and used Cartoon diagram is.
--SteveClement (talk) 19:04, 13 November 2015 (UTC)
thread_title:  Cartoon diagram 

message: I wonder why [17] ( Robinson S, Goddard L, Dritschel B, Wisley M, Howlin P (2009). "Executive functions in children with autism spectrum disorders". Brain Cogn. 71 (3): 362–368. doi:10.1016/j.bandc.2009.06.007. PMC 3481002. .) is listed as one of the sources supporting the following statement: "The gene variant has been shown to affect cognitive tasks broadly related to executive function, such as set shifting, response inhibition, abstract thought, and the acquisition of rules or task structure." The paper does not seem to mention the COMT gene at all, neither Val158Met polymorphism. 
Suggesting to remove the reference.  — Preceding unsigned comment added by 110.174.70.46 (talk) 15:12, 2 July 2015 (UTC)
thread_title:  Irrelevant source 

message: The first three sentences of this section are unclear and cite contradictory findings. Lachman et al are cited as finding a four-fold difference in overall activity (Met having lower activity). Zhu et al say they find Met overexpression (but agree with Chen et al's finding of an overall 40% decrease in activity). Chen et al say that their 40% difference in activity 
 :"is much lower than the 2–4-fold differences reported by other groups (Weinshilboum and Raymond 1977; Scanlon et al. 1979; Lotta et al. 1995). Heat pretreatment has been used to test the thermostability of Val and Met in many studies, and the remaining COMT activities after heat pretreatment were then used to calculate the differences between these alleles. Since we did not use heat pretreatment to estimate the COMT activity difference in the DLPFC samples, the 40% difference for prefrontal COMT activity may be more representative of the real difference under normal physiological conditions."  
Note that they ascribe the difference to methods (heat treatment) rather than to the effect of differential expression. The "however" in the wiki text "However, the Met variant is overexpressed in the brain,[14] resulting in a 40% decrease" is what confuses me, and I think it should be taken out.
Without delving further, I'd say that it's best to decomplexify, leave out the differential expression, and simply state something like "Protein activity of brain tissue examined in vitro is reduced in the Met allele (anywhere from 40% to four-fold, depending on assay methods)" and cite all three papers.
 
--Ajasen (talk) 02:48, 18 June 2013 (UTC)
thread_title:  The Val158Met polymorphism 

message: It would be helpful to add info on frequencies of occurence for this gene, particularly as the connection to mental illness is very topical lately -SM 04:33, 11 December 2005 (UTC)
thread_title:  Frequency of occurence in human population 

message: This is a good start, but references are needed for some of the statements 155.198.63.112 14:03, 12 April 2006 (UTC)
thread_title:  References needed 

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thread_title: Impact of recent student edits

message: Seems like some of the study information from this http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?pagewanted=all&_r=0 "Why Can Some Kids Handle Pressure While Others Fall Apart?" should be included in the page. This page appears to give very little low level introductory information. Pbhj (talk) 12:48, 10 February 2013 (UTC)
thread_title:  Reactions to presssure situations 

message: Should the name be "Catechol-O-methyltransferase" or "Catechol O-methyltransferase"? It seems that most research papers favor the version with a hyphen on both sides of the O, whereas most gene/protein databases favor the version with no hyphen preceding the O. Natureium (talk) 16:05, 20 March 2018 (UTC)
replies: text: You might propose the way you like by making an estimate of which use is more common, and then trying to add weight to the uses where more humans read and write a term versus less weight for publications which machines more commonly read.  Blue Rasberry (talk) 16:11, 20 March 2018 (UTC)
replies: text:  ,  The other naming question is whether there should be a space between the methyl and the transferase. I found this when I was cleaning up :Category:Pages with disallowed DISPLAYTITLE modifications.Naraht (talk) 16:39, 20 March 2018 (UTC)
replies: text:  The methyltransferase version is far more common (>10x on clinicalkey), but I can't determine what is more correct in terms of hyphenation. Natureium (talk) 22:16, 20 March 2018 (UTC)
thread_title:  Name