lflage/wiki-talks huggingface dataset:
Talk:Cathepsin

message: I think this article is a little confusing as to what a cathepsin is, which in turn seems to be compounded by the information in the pfam box.
If my understanding is correct, they're a quite general grouping of proteolytic enzymes that catalyze the hydrolysis of proteins into polypeptides ((http://www.thefreedictionary.com/cathepsin)) and not a family in their own right as implied by the article.
If I've understood correctly, we need to make it clear that this general term covers members of several different families and that the members themselves are not by implication evolutionarily related or directly similar in the modes of action - merely by the product of their activity.
I hope that makes sense, I have a tendency to ramble when trying to make a point :s
Abergabe (talk) 10:20, 10 August 2010 (UTC)
thread_title: Cathepsin Overview
Talk:Cell-penetrating peptide

message: https://www.cell.com/cell/fulltext/S0092-8674(18)30958-9
Maybe information about this could be included? English is not my native language and I could not keep the standard of the current article otherwise I would add it myself.  — Preceding unsigned comment added by 24.63.171.80 (talk) 23:57, 10 September 2018 (UTC)
replies: text: Just a note to let you know this article was expanded as part of a graduate level biomembranes assignment at the University of Florida. You can see the project page here. As a result, the student responsible for the expansion may not respond quickly now that the assignment is over. I have encouraged the students to see the articles through GA, but alas...the spring semester is drawing to a close. We shall see. --Moni3 (talk) 21:54, 28 April 2009 (UTC)

text: Good assignment concept and good work on the part of the students! JonMoulton (talk) 16:56, 8 May 2009 (UTC)
thread_title: Untitled

message: "Current use is limited by a lack of cell specificity in CPP mediated cargo delivery"
What do you mean by lack of cell specificity ? Happenened to read this:
"The enhancing effect of the tested CPPs was more obvious in the normal tissue and in some specimens we detected a striking selectivity of CPP-ABG complexes for the normal tissue"
http://www.mdpi.com/1424-8247/3/3/621/
--Bstard12 (talk) 12:37, 21 July 2010 (UTC)
thread_title:  lack of cell specificity
Talk:Cellulin

message: The "Research" section seems to cite only primary source articles. For descriptions of both cellulin's role in corneal repair and insulin production, the content is based on only one source each instead of an amalgamation of sources or on reviews. --Hildegard Mascarpone (talk) 05:15, 22 April 2024 (UTC)

message: — Assignment last updated by Lorna Moo (talk) 15:00, 1 December 2022 (UTC)
thread_title: Wiki Education assignment: CHEM 378 - Biochemistry Lab

message: — Assignment last updated by Bubbstar (talk) 20:11, 15 May 2023 (UTC)
thread_title: Wiki Education assignment: CHEM 378 - Biochemistry Lab - spring 2023
Talk:Chemical specificity

message: Test  — Preceding unsigned comment added by Davidho3 (talk • contribs) 06:10, 5 May 2016 (UTC)
thread_title: Untitled

message: Hello Wikipedia users,
I plan to develop the chemical specificity page with the following edits in the near future and would appreciate any feedback or concerns.
The primary changes entail:
1)  A section regarding the sources responsible for chemical specificity. This includes a description of how electrostatic and hydrophobic effects often play an integral role in how attraction occurs between two molecules. Shape complementarity is also crucial for chemical specificity. Text on how these attractive forces along with shape complementary combine to tremendously affect chemical specificity will be discussed.
2) The different types of categorizations that fit under the general umbrella of chemical specificity.
* absolute specificity
* group specificity
* linkage specificity
* stereochemical specificity
3) The importance of chemical specificity 
There are various areas in which chemical specificity is necessary.
I am planning to split these section off until two sections: its importance in relation to biological function processes such as hemoglobin and its importance in releasing oxygen throughout the body, as well as importance in relation to research techniques and advances such as immunostaining.  — Preceding unsigned comment added by Davidho3 (talk • contribs) 06:37, 5 May 2016 (UTC)
thread_title:  Proposed edits of this page 

message: A differentiation between specificity and selectivity would be helpful. Unfortunately I coudn't find any good sources for that yet, it seems like those two terms are mostly used interchangeably.
Anataban (talk) 19:41, 26 December 2017 (UTC)
thread_title:  Specificity - Selectivity
Talk:Preservation Resource Center

message: It would be nice if some newspaper articles and non-PRCNO sources could be added to this article.  A brief update on what PRCNO is doing today would also be helpful.  PRCNO is now one of many local organizations, including the St. Bernard Project, Operation Helping Hands from Catholic Charities, and Beacon of Hope in Lakeview and Gentilly that are now actively involved in rebuilding the city and attract thousands of out-of-state volunteers each year.  That information should also be added to the woefully inaccurate and out of date Recovery of New Orleans article.  winstonho0805 (talk) 20:19, 23 March 2010 (UTC)
thread_title: Untitled
Talk:Marquis reagent

message: In the second paragraph, methadone is listed as an opiate that can be tested with Marquis.  Marquis can be used to test methadone, but methadone is not at all an opiate, and should not be listed as such.  It has opiate-like effects on people, but it is not structurally related to any opiates and therefore would not react with Marquis in the same fashion as, say, heroin. 206.194.127.112 (talk) 22:43, 6 April 2009 (UTC)
thread_title:  Opiates 

message: There are three significant Alloys in the List, which have almost no explanory power at all:
- Dristan is an Alloy of Acetaminophen, Phenylephrine and Chlorpheniramine.
- Excedrin enthält Paracetamol, ASA and caffeine
- Mace contains as a grinded pit of a fruit a lot of different Alkaloides
I would delete all of them because each of these "test scores" is a mixture of colors which leads to no concrete inference. --78.52.194.180 (talk) 15:16, 6 August 2010 (UTC)
thread_title:  Alloys 

message: Marquis, Mecke, Mandelin, Simon and even Robadope... Everyone knows these reagents, but who were they named after? 91.85.166.51 (talk) 18:00, 19 March 2012 (UTC)
thread_title: Who were they?
Talk:Cholesteryl ester

message: Article questions
*Is it really necessary to open with "A cholesteryl ester is, as its name would imply, an ester of cholesterol" ?
*Is cholesteryl ester really synonymous with cholesterol ester?  Vokesk (talk) 22:54, 30 April 2012 (UTC)
thread_title: Untitled

message: — Assignment last updated by Tobeornottobe1 (talk) 21:09, 4 May 2024 (UTC)
thread_title: Wiki Education assignment: CHEM 378
Talk:Jacob Golomb

message: Despite the fact that half a dozen people weighted to say "keep" in the deletion discussion, not a single one of them actually edited the article in any way-- it still fails to state any reason why the subject is notable, and thus the article still meets the written criteria for speedy delete (A7: "article does not indicate why its subject is important or significant.")
I am frankly puzzled as to why people are thrilled to weigh in on the deletion discussion, but don't have any interest in making even a cursory edit on the article itself, not even to add the links that they went to the trouble of finding to post to the deletion discussion.
So I edited the article to incorporate the links posted by Eastmain and Mind meal in the deletion discussion-- now there's at least a hint of some explanation of notability.
While I was at it, I also deleted the statement of which languages this guy speaks.  Speaking three languages does not make you notable. Geoffrey.landis (talk) 14:48, 27 February 2008 (UTC)
thread_title:  Still no indication of notability
Talk:Chromosome combing

message: The Wiki should perhaps be changed to molecular combing, with chromosome combing described as the original development of the technique, as molecular combing is now used for more than chromosomes: Stretching desmin filaments with receding meniscus reveals large axial tensile strength. Balázs Kiss ⇑, Miklós S.Z. Kellermayer. Journal of Structural Biology. 2104 e-pub radcen (talk) 21:21, 14 May 2014 (UTC)
thread_title: Untitled

message: How do we study DNA replication timing and origin location on chromosomes removed from cells and splayed out in non-physiological arrangements?
173.25.54.191 (talk) 20:16, 6 June 2014 (UTC)
thread_title:  Needs explanation 
Talk:Coding region

message: Shouldn't this article be merged with exome ? As far as my understanding goes they are one and the same, and given exome sequencing is becoming an increasingly popular technique, it seems more logical the article should be called 'exome'. Harveyjamesm (talk) 21:45, 10 May 2018 (UTC)
thread_title: Untitled

message: What is the rest of the gene called? Explaining this contrast would give the context that would make the article much more informative. -Pgan002 (talk) 02:10, 26 March 2011 (UTC)
thread_title:  What about non-coding regions? 

message: http://www.newton.dep.anl.gov/askasci/mole00/mole00772.htm
http://www.sciencedirect.com/science/article/pii/S0378111902005061  — Preceding unsigned comment added by 129.67.45.61 (talk) 15:30, 8 May 2012 (UTC)
thread_title:  CDS acronym 

message: While the point was brought up that the exome page and the coding region page could be merged, we updated the article to make a distinction between these two terms since they are not interchangeable. We also added additional relevant section and removed sections that felt as "after-thoughts." We also added images to the coding region page since the pack lacked such illustrations that have the potential to increase reader understanding of relevant concepts. These edits were made by students of Nils Walters Nucleic Acids Class during the Fall 2019 semester. 
Pragpats (talk) 20:21, 19 November 2019 (UTC)
thread_title:  Updated Coding Region Page
Talk:Paul Guyer

message: Entry does not come across as subjective. Several claims without backup. Guyer's work is heavily disputed within Kant scholarship.  —Preceding unsigned comment added by 87.84.29.22 (talk) 21:38, 19 April 2011 (UTC)
thread_title: Untitled

message: I don't understand: who is Jonathan Nelson?  — Preceding unsigned comment added by 79.177.217.91 (talk) 12:33, 23 October 2020 (UTC)
thread_title: Jonathan Nelson
Talk:Caroline Walker Bynum

message: Prof. Bynum is known by her full name, Caroline Walker Bynum.  That should be the title of this article.  I would make the change myself but I don't know how.
This article says nothing about the substance of Prof. Bynum's work.  Hopefully someone knowledgable about her work will contribute.
The article title has now been changed! I've tried to locate a photo to add to CWB's page, but can't find a non-copywrite image. It would be amazing if this could be changed. Cpotter419 (talk)
I have also added in several citations and hence removed the header at the top which suggested more citations. Cpotter419 (talk)  —Preceding undated comment added 14:22, 28 March 2018 (UTC)
thread_title: Ongoing improvements
Talk:White Latin Americans

message: The Welsh were pioneers of the opening up of Argentine Patagonia in the 19th century and there are still Welsh speakers there today. This is not mentioned in this article even though there is a separate wikipage about it.
https://www.google.com/search?q=welsh+patagonia&oq=welsh+patagonia&aqs=chrome..69i57j0l7.5253j0j7&sourceid=chrome&ie=UTF-8
— Preceding unsigned comment added by 84.93.72.220 (talk) 6:07, 20 April 2020 (UTC)
thread_title:  Argentina - no mention of the Welsh in Patagonia 

message: The one drop rule establishes that even if one grand-grand parent was Amerindian, the person is considered Amerindian, regardless of the other seven grand-grand parents being pure white.
Similarly, if one grand-grand parent was black, the person is black or mestizo, even when they may look striklingly European.
People must have full European ancestry to be regarded as white in the forementioned studies.  — Preceding unsigned comment added by 2800:40:28:1155:31E3:7264:B813:41D1 (talk) 03:03, 13 August 2023 (UTC)
thread_title:  One Drop rule in Argentina studies 

message: There is no such thing as a White Dominican, the actual White Dominicans makeup 2% of the population and they are all old people that have a little bit of time left to live, what they call White in the Dominican Republic are lighter skin biracial, with nappy kinky hair 4c hair, with strong African features, and no European features, and most of the time they don’t even have light skin, they have natural brown skin, not tan, like actual brown skin, most White Dominicans would be seen as brown or black in other Latin countries Salina828 (talk) 03:30, 27 November 2022 (UTC)
thread_title:  White Dominicans 

message: Since most latin americans are mixed race, only a blood ancestry study or an AI analyzing images could determine a reasonable number. If you ask people if they feel white, some complexes could appear on the answer since for some countries (being white gives you socialstatus). Some errors are that, in Brazil most people do not view themselves as black (since this gives you a low  social status) and only 7% answer that they feel black, however accourding to some analytic and blood studies, the black population should double that number.  Other was if ask if you feel white, more chileans said in proportion that they feel white than argentineans, which is completly mistaken, since analytic and blood studies suggest way more euroean bloodline on Argentina than in Chile. 
I recommend checking again those numbers on the table with more reliable information, rather than just polls  asking people how they feel. 93.240.150.37 (talk) 16:19, 21 July 2023 (UTC)
replies: text: The article documents both self-identity and genetic makeup. Neither is "wrong", even if the percentages are seem contradictory. Dhtwiki (talk) 03:44, 22 July 2023 (UTC)
thread_title:  White Latin Americans: Hard to quantify
Talk:Lauren Myracle

message: lauren myracle`s books ROCK!  —Preceding unsigned comment added by 99.144.193.171 (talk) 20:19, 13 March 2010 (UTC)
thread_title: Untitled

message: Is this her real name or her pen name? If it's a pen name, her real name should be mentioned. If it's real, maybe that should be mentioned somehow; opinions?  —Preceding unsigned comment added by 89.134.183.57 (talk) 11:02, 6 October 2010 (UTC)
thread_title:  Real name? 
Talk:Polish Catholic Church

message: This article appears to have been brought over and machine translated from the polish version of the wiki page. It's mostly incoherant and definately needs the help of a polish speaker to jump over to the polish page, then come back here and make sense of things.  As it stands the text is too incoherant to make much sense of, aside from a bare gist of what it's trying to convey. --Lendorien 20:39, 15 February 2007 (UTC)
replies: text: A Polish wikipedian helped out here on February 25th, 2007 and did some translation. He did not do all of the text, but a significant part was taken care of.  Some additional translation of the portions near the end after the fall of communism would be useful to round out the article.  Has there been any fallout with the PLC regarding affairs with the communist government?  Other church organizations in Eastern Europe have had to deal with this. --Lendorien 22:56, 1 March 2007 (UTC)
thread_title: Translation Issues

message: Copy-edited the (English) article today for grammar and clarity. ThisIsAce 19:14, 13 June 2007 (UTC)
thread_title: Copy-editing

message: The article could use some more smoothing-out as far as grammar and syntax are concerned. I'm putting up a tag as a reminder. Noble-savage (talk) 05:56, 24 July 2009 (UTC)
replies: text: I tried my best, but a second pair of eyes couldn't hurt. -Pax85 (talk) 04:35, 7 March 2011 (UTC)
thread_title:  More copyediting needed 

message: Apart from the Traditional Anglican Communion, the article should really consider verifying whether groups within the Polish Catholic Church have ever sought a similar canonical structure to the proposed personal ordinariates. ADM (talk) 05:35, 3 December 2009 (UTC)
replies: text: extremely unlikely - there is simply no desire, the members are members for a reason i.e. they have family history with the Polish Catholic Church or with recent "converts" either have sincere disbelief in papal authority or more likely have an axe to grind with the Catholic Church. If they ever wanted to leave the Utrecht Union they would probably do so by entering communion with the mother church in America.Zantorzi (talk) 03:33, 9 December 2009 (UTC)
thread_title: Talk:Personal Ordinariate
Talk:Yanggakdo Stadium

message: https://www.google.co.uk/maps/place/Yanggakdo+Stadium/@38.9915601,125.7424961,439m/data=!3m1!1e3!4m14!1m7!3m6!1s0x357e026222e2a80f:0x9f3bf0dd563f43e4!2sEmbassy+of+the+Islamic+Republic+of+Iran!8m2!3d39.035975!4d125.7858887!16s%2Fg%2F11gjp4th4b!3m5!1s0x357e035582940285:0x443b963a7de96b1b!8m2!3d38.9916101!4d125.7435797!16zL20vMGJkdm54 Xophe84 (talk) 23:05, 11 February 2023 (UTC)
thread_title:  Appears to be derelict as of 2023
Wikipedia talk:Articles for deletion/Kal K. Korff

message: Angr,
WHY don't you contact Kal Korff directly and do some fact checking?
:For a couple of reasons. First, it's the responsibility of the people writing the article to get their facts straight; it's not my job to do their work for them. Second, Wikipedia content has to be verifiable on the basis of independent (i.e. not authored by him or people close to him), secondary, reliable sources. Information that comes directly from Kal Korff but that hasn't been published anywhere can't be used here. Third, I'm not questioning the accuracy of the claims made here; I'm questioning the neutrality of how they're presented. —Angr 05:18, 16 February 2007 (UTC)
Talk:Crick, Brenner et al. experiment

message: Was this the same paper that established the genetic code was degenerate (not a one-to-one mapping of codons to amino acids)? I don't have a library handy.
69.254.70.84 03:19, 19 July 2007 (UTC)
thread_title: Untitled

message: :I think that this article would benefit from being reorganized. I might divide the information into different sections (importance, the experiment, etc.). There are also lots of improvements that could be made content-wise. More citations are needed, and the experiment itself is cited in this article, which (I may be incorrect) I believe to be bad practice. Overall, this article reads more like a direct summary of the original scientific paper, and does not provide any new information on how the study has been influential in modern research. 
:I plan to organize the article into separate sections, and add more sources. I will use a review article by Charles Yanofsky on the experiment as a starting point, as well as other articles that have built off of this experiment. 
:I am working on this article for a class, and I would appreciate any suggestions!
Avevanduz (talk) 06:05, 23 March 2017 (UTC)
replies: text: Does anyone have suggestions for additional sources or literature that could provide further insight into the implications and influence of the Crick, Brenner et al. experiment on modern research? I'm particularly interested in exploring how subsequent studies have built upon or diverged from the findings of this landmark experiment._Risaislam (talk) 16:53, 12 April 2024 (UTC)
thread_title:  More Information and Organization Needed 

message: The reorganisation and edits to the content of the page both look great! My only feedback is that it seems relevant to link to the experiment itself somewhere in the article, which you mentioned to believe to be bad practice. Perhaps you could add it as a citation to the first sentence of the summary of the page? It would make it easier for future readers to find the experiment in question, in order to learn more. 
392MetabolicEditor (talk) 18:51, 9 May 2017 (UTC)
thread_title:  Feedback on Page Edit 

message: — Assignment last updated by Smfilosa (talk) 00:54, 4 May 2024 (UTC)
thread_title: Wiki Education assignment: CHEM 378
Talk:Cripto

message: It is necessary to understand the literature using the term crypto-1, since both pages Cripto (CFC1B gene) and Teratocarcinoma-derived growth factor 1 (TDGF1 gene) refer to literature using the same term crypto-1. For example link in this article:
Liu Y, Qin Z, Yang K, Liu R, Xu Y (March 2017). "Cripto-1 promotes epithelial-mesenchymal transition in prostate cancer via Wnt/β-catenin signaling". Oncology Reports. 37 (3): 1521–1528. doi:10.3892/or.2017.5378. PMID 28098905   it is about CR-1 (Teratocarcinoma derived growth factor 1)
also in == Clinical significance ==
text is about CFC1B gene, but the link is given to  
Park KS, Raffeld M, Moon YW, Xi L, Bianco C, Pham T, et al. (July 2014). "CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance". The Journal of Clinical Investigation. 124 (7): 3003–15. doi:10.1172/JCI73048. PMC 4071378. PMID 24911146. ("CRIPTO1, also known as teratocarcinoma-derived growth factor 1 (TDGF1)"  Dmitry Dzhagarov (talk) 12:23, 12 September 2021 (UTC)
thread_title: Untitled
Talk:Messiah ben Joseph

message: It says that "Traditional Christians do not believe in the concept of the Messiah ben Joseph or that Jesus Christ was descended from the tribe of Joseph. Instead, the Christian worldview holds that the Messiah ben Joseph is a rabbinic invention, composed in the Talmud centuries after Christ lived and after the New Testament of the Bible was formulated.": As a devout Christian myself (Catholic to be more precise), I would like to suggest a different idea as to how Our Lord Jesus fulfills Messianic Prophecy concerning Messiah ben Joseph: Simply put, let us remember who Our Lord's Guardian was? St. Joseph. --Splashen (talk) 00:04, 7 January 2024 (UTC)
thread_title: Christian Views: Traditional

message: ::The following text was removed from Jewish Messiah but could be helpful here, however, the sources should be checked:
The Messiah Son of Joseph is a personage mentioned in the Talmud and other Jewish sources. It is said that:
*He will be a forerunner of the Messiah Son of David.
*He will gather the Jews to the Land of Israel.
*He will restore the rituals of Temple worship.
*He will be slain in battle by Armilus, a Son of Satan.
*Messiah Son of David will raise him back to life.
*Will be from the Tribe of Ephraim.
Sources in the Talmud:
*Babylonian Talmud (Talmud Bavli), Tractate Sukot 52a.
*Jerusalem Talmud (Talmud Yerushalmi), Tractate Sukot 55b.
*Tractate Sanhedrin 98b.
Famous men who have been proposed as candidates to be identified as the Messiah Son of Joseph:
*Jesus
*Joseph Caro
*Haim Vital
*Joseph Smith Jr.
*Theodor Herzel
*All of the above, and many others. There is a school of thought in Judaism that the prophecies are to be fulfilled not by just one man, but by many - one or two in every generation.
Rwf5 20:45, 15 February 2007 (UTC)
thread_title: Messiah ben Joseph text from Jewish Messiah article

message: Over the years this article became high corrupted with Messianic Jewish and or Christian interpretations. I have been working a while on it and have cleaned it up. But it remains something to watch. Since this article is related to Jewish religious beliefs it is important not to corrupt it again.  
Messianic Jewish interpretations should get their own page and can link here. David C. Mitchell has written extensively on this topic. However, I don’t believe that he is widely accepted outside of Messianic Jewish circles. He takes a classic Christian evangelical approach.
Jonney2000 (talk) 02:10, 7 February 2014 (UTC)
thread_title:  Please do not added Messianic Jewish interpretations here