Talk:Antihistamine

message: Many of the drugs cites are actually used to treat psychosis etc. except loratadine (= claritine) and fexofenadine (=telfast which I added). Are there no other antihistamines in the classical sense, treating allergies? Sikkema (talk) 20:08, 1 June 2008 (UTC)
replies: text: Yes, of course; they're listed at H1 antagonist. Fvasconcellos (t·c) 22:30, 1 June 2008 (UTC)
thread_title:  Unclear 

message: This is a very complicated article, that the average person researching would have no idea. It would be nice to have things explained a bit more in laymans terms.  —Preceding unsigned comment added by 124.186.190.119 (talk) 06:34, 31 July 2008 (UTC)
replies: text: It has now been six years since the initial comment in this section asking for a less-technical explanation of what antihistamines are, and so far nothing has been done about it.  I am going to take this as encouragement to rewrite the intro, at least, and put it in terms that are much less technical and less medical, saving that stuff for later on in the piece.  If anyone decides to undo this action, please make sure you read this talk page entry first and justify your actions.  Thanks. KDS4444Talk 19:15, 31 January 2015 (UTC)
thread_title:  Audience 

message: "Large doses of vitamin C are known to alleviate shock by inhibiting deaminizing proteins that release histamine.[4]"
Source: http://www.seanet.com/~alexs/ascorbate/197x/klenner-fr-j_appl_nutr-1971-v23-n3&4-p61.htm
I question this (and just removed it), as the only source listed smells of a lone kook, though maybe there's a body of research supporting this I'm unaware of. I suggest if it goes back in that stronger sources be used. 74.230.169.130 (talk) 02:26, 18 October 2011 (UTC)
thread_title: Vitamin C

message: Does anybody know? I'd like such information to be part of the article. I think it's a fair guess that they do, since receptors usually increase or decrease in amount to compensate for artificial intervention. But I don't know. Again, would like to. Firrtree (talk) 06:36, 1 November 2012 (UTC)
thread_title: Do antihistamines lose effectiveness as sleep regulators over time?

message: The standard 10 mg dose of cetirizine knocks me out. Church and Church, "Phermacology of Antihistamines," suggest "levocetirizine may cause somnolence in susceptible individuals," implying that it doesn't in others, and that this depends on patient susceptibility rather than just the dose. 173.66.5.216 (talk) 23:52, 28 May 2017 (UTC)
thread_title:  Dose vs. Patient Susceptibility 

message: Because other popular sources of information focus on antihistamines for allergic rhinitis, the primary article on antihistamines in Wikipedia should also have that focus.
There two main meanings for the term "antihistamine".
*scientific perspective - an antihistamine is any of the class of drugs which oppose the activity of histamine receptors
*layman perspective - an antihistamine is a drug which treats allergies, specifically allergic rhinitis
The current version of this article emphasizes the scientific perspective rather than the common meaning of the term. There are comments on this talk page that this article is unclear and that it is not appropriately written for its audience. Most people use the term "antihistamine" irrespective of drug class to talk about the common experience of having allergies from springtime, or dust, or animal sensitivity. Here are some popular sources of information which use the term "antihistamine" in the sense of an allergic rhinitis treatment. MedlinePlus, for example, sidesteps the issue by calling their article "antihistamines for allergies", 
*
*
*Antihistamines at Mayo Clinic
As supporting evidence that this article is getting mostly layman readers and not sciences, consider the 2016 traffic which was 637,750 pageviews. This ranks around English Wikipedia's #15,000 article by popularity, or within the top 0.3%. Anything over 260,000 views is among the top 1%. Articles which do not have popular interest never have this many pageviews, and because of this, I feel that this is an article with layman readers who expect to find the layman use of the term used here. Perhaps another article, Antihistamine (drug class), could contain information about all the varied types of antihistamines and their uses beyond treating common allergies.
For now, I am going to add content to this article to promote the layman use of the term. I am going to make other experimental changes and discuss those here on the talk page. I would appreciate other comments about the direction of development for this article.  Blue Rasberry (talk) 18:49, 29 June 2017 (UTC)
thread_title:  "Antihistamine" article should be about treatments for allergic rhinitis 

message: As I described above, I am advocating for a perspective shift for this article to be about "antihistamines for allergic rhinitis" rather than "antihistamines as drugs which have a certain mechanism of action".
I just added sections titled "history", "society and culture", "special populations", and "research". At MEDMOS, our manual of style for medicine, we recommend that articles have these sections. When I added these sections, I focused on "antihistamines for allergic rhinitis". There could be other stories told for other sorts of antihistamines.
Thoughts from anyone?  Blue Rasberry (talk) 19:03, 29 June 2017 (UTC)
thread_title: Social issues around antihistamines for allergic rhinitis

message: I just changed the lead of the article. I would appreciate comments. In my version, I introduced the concept as "drugs for allergic rhinitis".
Antihistamines do more than this. I do not think that this article should cover every sense of the term. I also do not want it to be too narrow.
Thoughts from anyone?  Blue Rasberry (talk) 19:18, 29 June 2017 (UTC)
thread_title:  Change of lead - comments requested 

message: The article is now very negative of long-time use of antihistamines. This also might have benefits, not only risks.
"A study published in the September 2010 issue of “Gut” demonstrated that Ketotifen, a mast cell-stabilizing antihistamine, decreased symptoms and improved quality-of-life measurements in 60 patients with IBS". 
https://www.livestrong.com/article/532033-can-taking-an-antihistamine-help-ibs/
ee1518 (talk) 16:30, 29 January 2018 (UTC)
thread_title:  Long-time use for allergies, and for Irritable bowel syndrome, or IBS. 

message: H1 antagonists
Examples of H1 antagonists include:
...
Cetirizine (Zyrtec)
...
H1 inverse agonists
The H1 receptor inverse agonists include:
...
Cetirizine (does not cross the blood–brain barrier)
-----
If it is indeed both, noting that there would be helpful.  — Preceding unsigned comment added by 70.51.240.103 (talk) 03:42, 1 July 2018 (UTC)
thread_title:  Cetirizine listed as both H1 antagonists and H1 inverse agonists. Huh? 

message: The article previously stated most antihistamines are antagonists, but the medical research does not reflect this.
https://www.nature.com/articles/s41467-023-44477-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666185/
https://pubmed.ncbi.nlm.nih.gov/11972592/ 2600:6C65:7C7F:F0DF:34D2:6EFF:FE66:DDAB (talk) 04:51, 4 June 2024 (UTC)
thread_title:  Medical research labels most antihistamines as inverse agonists, yet article says otherwise