Talk:Synaptic plasticity

message: The section "Biochemical mechanisms" starts - once again - with praise to Eric Kandel. Granted, he has contributed a lot and won a Nobel price for the field, but studying synaptic plasticity is - like almost all science - still a group effort. This is demonstrated e.g. by the fact that the cited paper doesn't even list him as a co-author! (Btw. he also has only one and not several "laboratories" as implied in the text). Many neuroscience related articles on Wikipeadia sound like he invented the field - which he didn't. I sometimes wonder what the other 39999 members of the Society for Neuroscience do all day long and can't help but wonder WHY his name comes up so frequently.  —Preceding unsigned comment added by 146.203.21.90 (talk) 21:02, 18 October 2010 (UTC)
replies: text: Please feel free to edit the article to fix the problem.  If there is any way I can be helpful, please say so. Looie496 (talk) 03:01, 10 November 2011 (UTC)
thread_title: One more Kandel praise page

message: This summary is aweful. Misses the key points and focuses individual achievements that
are irrelevant such as changes in ion channels. Even that is not explained well. Sure
LTP protocols *can* result in more than just LTP of the synaptic strength, called 
EPSP-to-spike potentiation (an increase in the probability that a spike will be triggered
for the same input strength). That indeed relies on ion channel plasticity amongst other
things. 
Please someone, fix this!
I agree. This article seems overly technical. JohnJohn 18:56, 23 January 2006 (UTC)
replies: text: This article is very basic: Brain Basics Synaptic Plasticity Synaptic transmission is plastic SriMesh | talk 02:08, 26 December 2008 (UTC)
thread_title: Too technical

message: I think this article also got exocytosis and endocytosis swapped.  According to what I read on the endocytosis and exocytosis articles on wikipedia, exocytosis is the process of a cell removing contents out from itself, whereas endocytosis is absorbing contents into itself.
:As far as I know, the article is currently factual. AMDARs are taken to the cell membrane by EXOcytosis (to move out from the cell body) and are reabsorbed back into the cell body by ENDOcytosis. They never actually leave the cell. SamuelRiv (talk) 08:40, 21 November 2007 (UTC)
replies: text: Regardless of that, the use of exocytosis (used almost exclusively to describe vesicle fusion with membrane and neurotransmitter difusion across synaptic cleft) and endocytosis (vesicle recycling after exocytosis) is very misleading. I have never seen either used in the context of plasticity. Paskari (talk) 17:37, 2 July 2008 (UTC)
thread_title: Exo vs endo

message: Well I will be coming back shortly to rewrite this section, just too busy at the moment. But so far I think there should be 5 parameters used when describing synaptic strength
# number of vesicles (N)
# probability of vesicle release (p) 
# postsynaptic response (q)
# synaptic delay (which corresponds to total axonal delay)
# synaptic duration (which corresponds to the time the receptor remains in the open state, see Neuroscience Purves et. al. 2007, p131)
Did I miss anything? Paskari (talk) 18:23, 2 September 2008 (UTC)
thread_title:  Properties of synapses 

message: The theoretical mechanisms section is a little misleading. It should list 
#the probability of neurotransmitter release (p)
#the number of vesicles of neurotransmitters (N)
#the postsynaptic sensitivity to released neurotransmitters (q)
furthermore, the equation only seems to deal with q Paskari (talk) 17:02, 2 February 2009 (UTC)
replies: text: That whole section should perhaps be removed.  As you say, it doesn't even deal with LTP/LTD correctly, and there are many other types of synaptic plasticity that work in completely different ways. Looie496 (talk) 03:50, 3 February 2009 (UTC)
thread_title:  Theoretical mechanisms 

message: Hello fellow Wikipedians,
I have just added archive links to  on Synaptic plasticity. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive http://web.archive.org/web/20060829084511/http://www.psychiatry.wustl.edu/zorumski/journal%20club/Perez-Otano%20and%20Ehlers%209_23.pdf to http://www.psychiatry.wustl.edu/zorumski/journal%20club/Perez-Otano%20and%20Ehlers%209_23.pdf
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—cyberbot IITalk to my owner:Online 09:54, 28 February 2016 (UTC)
thread_title:  External links modified