Talk:Cytokine storm

message: Although a very interesting site, this is not a medical reference. Please provide a medical journal or textbook. Second, you fail to understand that severe infection also causes a "cytokine storm." Since SIRS is defined as absence of infection how do you differentiate between infection and non-infection related "cytokine storm?" Analogy: apples are fruit, but fruit not necesseraly refers to apples. In short, the assertion is incorrect. Please amend accordingly. Nomen NescioGnothi seauton 09:36, 30 May 2006 (UTC)
replies: text: Like the current version. Explains the concept very good. Thank you. Nomen NescioGnothi seauton 06:56, 31 May 2006 (UTC)
thread_title:  Cytokines & Cells Online Pathfinder Encyclopaedia 

message: BBC story on cytokine role in making H5N1 in humans deadly.— Preceding unsigned comment added by 205.175.225.22 (talk) 21:35, 11 September 2006 (UTC)
replies: text: Just wanted to point out that the cytokine storm concept is not entirely recognized within the field yet... There are some studies done on transgenic mice deficient in various cytokines showing that they have the same mortality as regular mice with H5N1... so cytokine storm is not the whole picture. 70.184.145.25 (talk) 08:44, 3 November 2009 (UTC)
thread_title:  Cytokines and H5N1 

message: Would selective anti-T-cell medications be useful in the treatment of cytokine storm (ex : tacrolimus ?) ?— Preceding unsigned comment added by 129.78.64.100 (talk) 08:37, 20 February 2007 (UTC)
thread_title:  Question 

message: Feline Infectious Peritonitis, formerly a rare disease in cats, is now found in about 1 of 20 purebred cats in 'average' American and European 'catteries'. Though still little understood, veterinarians claim death is rapid in healthy cats if infection is sufficient to trigger a response from the humeral immune system. If this is an example of a cytokine storm, it is, sadly, being experienced by more and more people who have feline family members. It may be useful as an example many people have seen first hand. Geologist (talk) 04:29, 25 May 2008 (UTC)
thread_title:  Can the feline FIP virus be used as an example? 

message: I understood that there were some great successes fighting cytokine storms by utilizing a new type of dialysis.  I read about these a couple of years back.  Currently, I can't find the citations however.  Has this therapy dropped out of vogue?  It seemed to hold a lot of promise, if only for individual patients as opposed to epidemiological uses.  —Preceding unsigned comment added by 206.109.195.126 (talk) 06:05, 10 November 2008 (UTC)
replies: text: Sounds more like plasmapheresis. That said, I can't find a reference for that treatment ever being attempted, hence, effectiveness is unknown.Wzrd1 (talk) 19:18, 3 February 2012 (UTC)
thread_title:  Dialysis / blood purification 

message: I think it is probably worth noting that at least one study (http://www.ncbi.nlm.nih.gov/pubmed/3112984) suggests that (at least in pigs) three commonly available OTC drugs can significantly reduce the most fatal effect of cytokine storms (ARDS) when used in combination.  Specifically, the drugs in question were Benadryl (an H1 blocker), Tagamet/cimetidine (an H2 blocker), and Ibuprofen (an antiinflammatory drug).  The funny part of that is that most people have at least two and possibly all three of the medications in question in their homes.
It might also be worth noting that some studies suggest Curcumin blocks TNF, so if TNF-alpha inhibitors prove effective, there is at least some possibility of a low-side-effect (mostly heartburn) treatment....
Dgatwood (talk) 05:20, 27 April 2009 (UTC)
thread_title:  Cytokine storms and Cimetidine (Tagamet), Curcumin 

message: Is there a difference between a "cytokine storm" and "endotoxic shock"? --GentlemanGhost (talk) 23:17, 27 April 2009 (UTC)
replies: text: Yes, there is a significant difference. In endotoxic shock, there is no cytokine storm, only high levels of SOME cytokines.Wzrd1 (talk) 19:20, 3 February 2012 (UTC)
thread_title:  Endotoxic shock 

message: This is one thing I have noticed about the drug industry: when dealing with an immune related disease they usually ignore the question of how anti-histamines affect the disease process. For example when antihistamines became available without a prescription the box labeling warned the product was not to be used by asthmatics, yet in the 1990's the FDA determined that that warning had no basis in fact.
Ribazole (talk) 14:50, 28 April 2009 (UTC)
thread_title:  Nothing Said about Antihistamine Effects 

message: Do alcohol and sugar help against cytokine storm by reducing the immune system? 193.190.253.144 (talk) 09:05, 1 May 2009 (UTC)
replies: text: No:  it's far too little, far too late in the game.  You need serious immunosuppressant pharmaceutical agents.  WhatamIdoing (talk) 00:05, 5 May 2009 (UTC)

text: I think the habitual use of immunosuppressants is not helpful. I have seen research suggesting that D3 deficiency causes it the cytokine storm and as most patients are deficient it might be a good idea to treat with massive D3 dose. There seems to be an attitude of best to close down the body's defences and let the doctors do the job. Even vaccines need a n immune system, they don't kill the virus on therir own, which some appear to think. Many studies round the world have shown the importance of D3 to immunity, and the 'coincidence' of all the deaths are of patients with deficient immune systems. Real scientists of course dismiss ;'supplements' as useless, which is why the UK government emeritus advisors refuse to consider it.  PetePassword (talk) 12:24, 24 January 2021 (UTC)
thread_title:  The question everyone is wondering 

message: There are numerous claims online that vitamin D  regulates cytokine (immunesystem) responses. Do these claims have any scientific research behind them? User:Nunamiut— Preceding unsigned comment added by 84.215.44.195 (talk) 13:24, 8 November 2009 (UTC)
replies: text: There are numerous claims online that Bigfoot exists, flying saucers have landed and taken over the world or even that the same is true, save that we won and that E does NOT equal MC^2. Hence, one must examine studies (non exist in the REAL world, only a few claimed studies that were sponsored by the company seeking a claim of benefit), published articles (none, in peer reviewed publications) and fact. Overall, every part in a system plays a part, but, NONE can play a key, as they're interlocked systems. In this case, it is a cascade of signals causing an overreaction of immune response. No vitamin would relieve it, but stronger drugs MIGHT interrupt the cycle of increasing cascade.Wzrd1 (talk) 05:05, 3 February 2012 (UTC)
replies: text:  Actually there is very strong evidence that vitamin D has a profound influence on the immune system () including regulating the production of some cytokines.  See for example  ,  (\downarrow\!TNF-α), (\uparrow\!TGF beta 1),  (\uparrow\!IL-10), and  (\uparrow\!IL-10). Boghog (talk) 07:51, 3 February 2012 (UTC)

text: There is circumstantial evidence that vitamin D (see ) may reduce the incidence and/or severity of cytokine storm.  Vitamin D boosts the innate immune system while damping the adaptive immune system in part by down regulating the production of pro inflammatory cyctokines.  While there is no direct clinical evidence that vitamin D deficient patients are at greater risk of developing cytokine storm, there is strong mechanistic rationale.  Finally, the name vitamin D is somewhat misleading.  Vitamin D is a steroid derived substance that regulates the expression of thousands of genes (including several cytokine genes) through binding to and activating the nuclear hormone receptor VDR.  Hence vitamin D is more of hormone than a vitamin.  It only become a vitamin (i.e., must be supplied by the diet) if one is not exposed to enough sunlight. Boghog (talk) 16:00, 4 February 2012 (UTC)
thread_title:  Vitamin D claims to regulate cytokine (immune) responses 

message: The literature presented here on the various therapeutic tracks being researched is very old -- little if any beyond 2007, some on apparent major Treatment emphases with literature limited to 2003 (nearly a decade ago).  For this reason, the tone and extent of each subheading under "Treatment" needs serious attention.  Something of potential early drug discovery interest in 2003-2007, without clear further attention in the pharma conference literature at least, is likely of no continuing practical interest. (Pharma ideas and molecules "die on the vine" all the time; to include past possible therapeutic tracks that are only of historic interest is likely not appropriate for an encyclopedic article.)  Moreover, there is reason to think that having little or nothing on therapeutic possibilities that are current, while listing those 5-10 years old, may actually be detrimental to the aims of wikipedia (insofar as dated scientific information can be misinformation, in its  incompleteness and misdirection in relation to current opinion). Bottom lines:  Update all under Treatment, etc., and reduce OX40 IG and ACE inhibitor sections if there is nothing substantial going on in these areas in 2013.  LeProf  — Preceding unsigned comment added by 67.175.245.235 (talk) 03:59, 24 December 2012 (UTC)
thread_title:  Datedness on citations, general thought on overstating therapeutic tracks (subheadings under "Treatment") 

message: A common assertion made in opposition to vaccination has been that vaccines can cause a cytokine storm, leading to adverse events. See Kathleen Stratton, Andrew Ford, Erin Rusch, and Ellen Wright Clayton, eds., Adverse Effects of Vaccines: Evidence and Causality(2011), Chapter 3: Evaluating Biological Mechanisms of Adverse Events, stating that "subtle imbalances of proinflammatory and anti-inflammatory cytokines may occur following immunization against rubella, human papillomavirus, or hepatitis B" and that "it is possible that the unique immunogenetic makeup of an individual might predispose that individual to an exaggerated cytokine imbalance following immune stimulation such as microbial infection or vaccine administration", but concluding that a review of vaccine literature reveals "no evidence that directly or indirectly supports the oversecretion of cytokines as an operative mechanism". I think we should cover this. BD2412 T 01:31, 31 May 2021 (UTC)
thread_title:  Relationship with vaccines