Talk:Acetylcholine receptor

message: The paragraph about the mAChR claims that "The alpha subunit of the G-protein activates guanylate cyclase (inhibiting the effects of intracellular cAMP) [...]".
This is in contradiction to basically all textbooks and the common understanding of GPCRs. Gs- or Gi-coupled GPCRs act on adenylate cyclase to increase or inhibit cAMP-production, respectively. Direct activation of guanylate cyclases should not be possible, given that GCs are ligand-activated enzymes (directly binding extracellular peptides or NO). The article about the muscarinic receptors does not even mention cGMP.
If this statement was actually true (which would come as a surprise to me), it would need a citation.  — Preceding unsigned comment added by MosesMaWo (talk • contribs) 06:04, 17 May 2023 (UTC)
thread_title: Contradiction to textbooks and article about muscarinic acetylcholine receptors

message: I believe nicotinic receptor slows the heart rate when ach binds to the receptor and it contradicts your description about acetylcholine receptor.  Please check and make corrections if neccessary.
Thank you,
yoko onishi
Hi Yoko - what is the specific contradiction? Acetylcholine receptors can be both excitatory or inhibitory depending on the subtype.
Someone should probably add a passing mention of the role these receptors play in the autonomic nervous system. 128.42.167.200 22:28, 20 February 2006 (UTC)
thread_title: Untitled

message: The picture was changed to the one used in acetylcholine because the old does not meet the criteria for chemical formulas.
-- Panoramix303 18:07, 8 November 2007 (UTC)
thread_title: Minor change

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thread_title:  External links modified 

message: The symbols '-' and '+', which probably denote agonist/antagonist action in the table, need to be explained in a legend. vkehayas 15:17, 26 May 2017 (UTC)
thread_title:  Table legend 

message: I feel like in this paragraph, the information bookending the sentence on Myasthenia Gravis is confusing, "Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at the neuromuscular junction is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine."
Because the first sentence is about nicotinic receptors and the last is about muscarinic receptors, but there is no mention or clarification of how either of these relate to Myasthenia Gravis.  I was trying to further understand the disease, but this section led to more confusion. Mangofirst (talk) 22:05, 3 February 2019 (UTC)
thread_title:  Wonky paragraph