Talk:Doxylamine

message: Please create an article for Restavit (Doxylamine is sold under the name Restavit in some countries) that redirects to this article. I had a hard time finding out what Restavit really was and I believe setting up this redirection might help others, thank you.  —Preceding unsigned comment added by 69.120.105.248 (talk) 19:53, 28 July 2008 (UTC)
thread_title:  Restavit 

message: How risky is doxylamine? Is there any risk for dependency? Zellthemedic (talk) 03:53, 14 July 2008 (UTC)
thread_title:  Dependency 

message: of course it is
   I'm not sure about that.
Well, according to http://en.wikipedia.org/wiki/Commonwealth Canada is a Commonwealth nation.
Canada is absolutely in the Commonwealth 149.135.110.235 09:29, 5 December 2006 (UTC)
thread_title:  Canada in the Commonwealth? 

message: The structural formula given in the diagram is false. It is missing an amine group in one of the rings.
Im not at all experienced at Wiki editting, so il ask if somebody else can find a correct structural diagram that includes all the amine groups. 220.233.195.181 12:30, 26 June 2006 (UTC)
thread_title:  Structural diagram 

message: I'm an insomniac, and I've tried this medicine as a sleep aid. I weigh 56 kg (124 lb). It comes in tablets   containing 25 mg. Try half a tablet. A whole tablet makes it very hard to get up the next day. Also, don't take two tablets at once. It made my skin and muscles hypersensitive, so that my blanket and mattress felt itchy, and it made my eyes and nose feel very dry (as one might expect from an antihistamine). Also, chasing half a tablet with a glass of wine is very effective as a "sleeping potion" of sorts. I hope this helps. Also, I don't find the article confusing, so I'm removing the tag. Peace be upon you. 24.95.48.112 09:54, 7 January 2007 (UTC)
replies: text: Consuming alcohol with any hypnotic can be dangerous.  Best to forego the chaser. 206.194.127.112 (talk) 21:55, 28 July 2008 (UTC)
thread_title:  Anecdotal information 

message: ----
This is the brand name used in the USA, I do not see this mentioned.  Maybe that would imply commercial endorsement, but the brand names in other countries is shown. —The preceding unsigned comment was added by Jokem (talk • contribs) 21:45, 25 April 2007 (UTC)
thread_title:  UNISOM 

message: According to the Wikipedia page on pregnancy categories (which appears to agree with the FDA):
Category A: Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Please cite an authoritative source before calling this category A, or adequate and well-controlled studies at least.  I have reason to suspect this is actually category B. Epylar 05:34, 30 April 2007 (UTC)
replies: text: I have not been able to find a single source that says that this drug is category A.  Since that is misleading and potentially harmful information, I am removing that information promptly.  --71.126.174.124 (talk) 19:23, 22 September 2011 (UTC)
thread_title:  Pregnancy Category 

message: How can the recommended dose be 50mg while the LD50 estimate is 50mg-500mg in humans?!
That is a drastic estimate if you ask me, 50mg would be enough to kill someone with a low tolerance to this drug.  —Preceding unsigned comment added by 24.231.241.197 (talk) 00:18, 19 January 2009 (UTC)
replies: text: That's 50–500 mg/kg, which works out to 3.5 to 35 grams for an average  man. Fvasconcellos (t·c) 00:48, 19 January 2009 (UTC)
thread_title:  Question about LD50 and recommended doses 

message: "It is also the most effective over-the-counter sedative available in the United States,[2]"
As there are only two otc sedatives avaliable in the US, this is hardly suprising! (the other is diphenhydramine)
121.209.49.58 (talk) 03:33, 3 November 2009 (UTC)
replies: text: Aside from alcohol (see section on Indications citations), there are herbal supplements sold OTC that have been proven to have sedative effects, although I suspect that none of these were considered by the source that made the claim. Unimaginative Username (talk) 00:56, 28 March 2011 (UTC)
thread_title:  OTC Sedative 

message: I noticed next to bioavailability it states that insufflation gives a 70% bioavailability as opposed to the responsibly dosed 20% by oral. This information may encourage consumers of Unisom® to insufflate the tablet rather than use as directed. This information should not be disseminated. Only the oral bioavailability should be stated as the FDA approved this substance for use ONLY be oral.
Unisom® is a registered trademark of Chattem, Inc.  —Preceding unsigned comment added by 74.140.1.231 (talk) 08:26, 9 November 2010 (UTC)
thread_title:  Encouraging bad behavior? 

message: Added the cites and removed the cite-needed tags. The claims were strong and in some cases counter-intuitive; hence the multiple cite of almost every single claim in the first paragraph. Some sounded almost like advertising hype, but if you check the source cited, it appears to be reliable and without conflict of interest in promoting this product. (However, I'd still wonder about the claim of "most powerful OTC sedative in the US" if alcoholic beverages were included in the comparison. They are sedatives, and they are sold over-the-counter to those of legal age, even though the *intended* use may not be medicinal.) Unimaginative Username (talk) 00:27, 28 March 2011 (UTC)
thread_title:  Indications citations 

message: I clicked on reference 2 expecting to see the study mentioned, but instead found a restatement of the sentence which had the citation.  Is the source of the original study known?  — Preceding unsigned comment added by John1492 (talk • contribs) 22:43, 28 November 2011 (UTC)
thread_title:  Reference 2 

message: The article states that it is one of the most effective pain medications available over the counter in the United States.  But then the reference that follows in a Canadian website...   While visiting the US, I stopped in a Rite Aid.  Not only is it not available, but it does not show-up in their computers, nor have they ever heard of it.  I corrected the article to say it can be ordered online from Canadian pharmacies.Bill C. Riemers (talk)  —Preceding undated comment added 13:05, 3 August 2012 (UTC)
thread_title:  Availability in the United States 

message: :Moved from article. Fvasconcellos (t·c) 21:23, 30 March 2013 (UTC)
thread_title:  Availability in Canada 

message: On looking at the molecular structure I can see that doxylamine has a stereogenic centre. Does anyone know which enantiomer is the pharmalologically active one? Seven of Nine (talk) 01:02, 5 March 2016 (UTC)
thread_title:  Chirality of doxylamine 

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thread_title:  External links modified 

message: This article currently says, "If used for longer periods of time, withdrawal effects are unlikely to be experienced with prolonged use, but mild withdrawal symptoms are likely if taken long-term." What is the difference between "prolonged" and "long-term"? Apparently one is unlikely to have withdrawal effects while the other is likely to have withdrawal effects, but how are they distinguished? 74.71.81.121 (talk) 16:39, 19 October 2019 (UTC)
thread_title:  Withdrawal effects over "longer periods of time"? 

message: "Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with a higher risk of cognitive decline and dementia in older people.[30][31]"
[30] does not mention doxylamine at all. [31] lists it in a table of frequency of use in the class, but both of these studies are about anticholinergics in general. The studies that I've seen that actually differentiate between different anticholinergics suggest that some have a much more significant impact than others and some have virtually no impact on dementia. As far as I can tell, there are no studies that put doxylamine into a category of risk beyond it being in the class of anticholinergic. Which is to say, there's no evidence, that I've been able to find, that it actually has an impact on dementia.  — Preceding unsigned comment added by 2600:1700:83E0:7360:7157:5308:448D:95B0 (talk) 16:06, 24 April 2023 (UTC)
thread_title:  Dementia