Talk:Ciclosporin

message: This is a good page, is there any objection to moving it to the INN ciclosporin and having cyclosporine redirect there?
Let "ciclosporin" redirect to cyclosporine which is the compounds real name. Cacycle 21:13, 21 Dec 2004 (UTC)
replies: text: As for previous point re using a compound's real name, no one is realistically going to move paracetamol across to 4-(Acetylamino)phenol (I trust)? David Ruben  Talk  11:46, 21 March 2006 (UTC)

text: Comment - Not European but Worldwide (as in WHO). INNs generally got rid of 'ph' for 'f' (hence cefalexin vs older cephalexin) and 'y' became 'i' (hence amoxicillin vs amoxycillin, aciclovir vs acyclovir). So Ciclosporin vs Cyclosporin should be apparent. (don't worry we too had great fun in UK learning bendroflumethiazide for bendrofluazide and furosemide for frusemide, but have been spared, for now, ephidrine for adrenaline) David Ruben  Talk  05:35, 22 March 2006 (UTC)

text: Indeed, in line with most other articles on medicines, standardised to INN names and so moved. Separate section on "Naming" is redundant as clearly now describes USAN and former BAN. David Ruben  Talk  00:29, 20 May 2006 (UTC)
thread_title: Cyclosporine to Ciclosporin move

message: Suggest removal of "It has also an effect on mitochondria. Cyclosporine A prevents the mitochondrial PT pore from opening and inhibits thus cytochrome c release, a potent apoptotic stimulation factor. However, this is not the primary mode of action for clinical use but rather an important effect for research on apoptosis." from the "mode of action" section. Reason given in last line of quote. --Username132 (talk) 22:36, 19 May 2006 (UTC)
replies: text: I disagree. I'm using this compound for research not directly related to what it is prescribed for as a drug. That paragraph was helpful. As it is, the article for cyclosporin, the chemical compound, is clearly wrapped up in this article for the drug. As such, this article should reflect more than just the mechanism of action of the drug as prescribed. 130.253.176.109 (talk) 20:04, 30 November 2010 (UTC)
thread_title:  Suggest deletion from mode of action 

message: During the initial investigation of it's possible use, one major issues facing its application was the lack of an effective solvent, that's until the accidental discovery by a Greek medical research student that it'd dissolve in olive oil. I find this most interesting but am uncertain of its encyclopaedic value. Should this be added to the article, and if so, where and how? Oosh (talk) 10:50, 20 January 2009 (UTC)
thread_title:  Olive Oil as a solvent 

message: The most popular drug for Ciclosporin in the United States is Restasis.Mdriver1981 (talk) 04:39, 25 June 2009 (UTC)
thread_title:  Restasis 

message: What the hell is /ɵ/? In which dialect of English is it a phoneme, used in this position?  —Preceding unsigned comment added by 92.124.45.8 (talk) 11:57, 3 August 2009 (UTC)
thread_title:  /ˌsaɪklɵˈspɔərɨn/ 

message: Somewhere in the main part of this article it should be noted that CYCLOSPORINE IS A KNOWN CARCINOGEN IN HUMANS.
http://monographs.iarc.fr/ENG/Classification/crthgr01.php
98.246.50.76 (talk) 01:39, 26 August 2009 (UTC)
thread_title:  IARC Group I Carcinogen 

message: I was about to translate this article into Chinese, but later I found out that it's written terribly...lol. Azathioprine, being also immunosuppressant, consisting of more than half "side effects", yet I only saw a few lines here (without even mentioning it's a IARC Group I Carcinogen). However, in fact cyclosporine has not much less adverse reactions than Azathioprine. Moreover, I don't think cyclosporine is THAT important on treating heart disease. It's only used experimentally so far, isn't it?--Jsjsjs1111 (talk) 12:51, 16 January 2012 (UTC)
thread_title:  Poor quality 

message: Hey everyone,
There's a lot of information about Cyclosporin A located here, if anyone is interested - http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdf - I don't have much time so I only included the bit about prevention and rejection of bone marrow, liver etc... But if anyone wants to add more info, there's a lot here.  --Activism1234 22:32, 10 July 2012 (UTC)
thread_title:  More information located at this link on cyclosporin A 

message: I have a correction and a reference for one of the needed citations in the beginning of the article but I am not firm with Wikipedia editing, so I will post it here: 
:"The cyclosporins were originally discovered in 1970 by workers at Sandoz Ltd. in Switzerland who were attempting to identify new antifungal agents."
Borel, J.F. 1982. The history of cyclo­sporin A and its significance. In Cyclosporin A: Proceedings of an International Conference on Cyclosporin A, ed. D.J.G. White, p. 5. New York: Elsevier Biomedical
  — Preceding unsigned comment added by 88.69.179.107 (talk) 08:19, 17 July 2012 (UTC)
thread_title: History 

message: I want to know why this hasn't considered for use with Hashimoto's Thyroiditis where one's own immune system gradually destroys one's thyroid making one dependent upon hormone replacement.  Any replies to this question would be greatly appreciated.Godofredo29 (talk) 01:02, 4 November 2013 (UTC)
replies: text: I would suggest asking at Wikipedia:Reference desk/Science.--Jsjsjs1111 (talk) 17:46, 5 November 2013 (UTC)
thread_title: Use With Hashimoto's Thyroiditis

message: Anyone can find how much Pycnogenol is probably safe (mg)?
All I know pycnogenol does not do much Acutely. Build-up effect is needed for best benefits.
http://examine.com/supplements/Pycnogenol/
http://examine.com/discussion/Pycnogenol/
----
http://www.webmd.com/vitamins-supplements/ingredientmono-1019-pycnogenol.aspx?activeingredientid=1019&activeingredientname=pycnogenol
Copy paste:
Medications that decrease the immune system (Immunosuppressants) interacts with PYCNOGENOL
Pycnogenol seems to increase the immune system. By increasing the immune system pycnogenol might decrease the effectiveness of medications that decrease the immune system.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
ee1518 (talk) 11:07, 18 February 2015 (UTC)
thread_title:  Interactions? For example, Pycnogenol? 

message: Of our 43 references, only two use the spelling 'ciclosporin.'  And one of these is a multi-source reference which include three other references with the spelling cyclosporin.
In fact, our entire reference list is filled with spellings of both cyclosporin and Cyclosporine, and it's not always entirely consistent on the matter of capitalization.  Do a control F for find and type in cyclo- and see what ends up highlighted.
I know we had this discussion before -- like ten years ago! -- but it sure seems like it's an affectation and we're trying to make some purist political point.  FriendlyRiverOtter (talk) 20:25, 7 December 2016 (UTC)
replies: text: Yep this has been discussed pretty much to death.  If you want to start a new move discussion please do so but please don't add further editorializing comments in the article.   Reviewing the discussions above, I don't think there is much likelihood that a move discussion will succeed.   I suggest you review the discussions as well.  Thanks. Jytdog (talk) 20:43, 7 December 2016 (UTC)
replies: text: Yup we go with INN. Similar to how just because the USA uses miles and has the largest publishing houses in the world does not mean the rest of the world cannot agree to go with metric. We are global and therefore use global standards. Doc James (talk · contribs · email) 05:12, 8 December 2016 (UTC)
replies: text: And of course, if we had an article about cyclosporin synthetase, per WP:COMMONAME, we would use the spelling cyclosporin and not ciclosporine. Boghog (talk) 05:43, 8 December 2016 (UTC)
replies: text: If ciclo- is the global standard, I'm all in favor of having it be the title of our article.  I can only say that what was common in our references and what was not, really jumped out at me.  And everyone, thank you and you're very welcome.  Thank you for the nice compliments.  Yes, I did make a good contribution by adding the alternate spelling cyclospirin.  Again, I did this simply by paying attention to our references.  And I'm glad we're all in favor of using common names.  I just hope we're not making it analogous to the Royal Spanish Academy where we might pay lip service to common usage, but then at the end of the day elevate some kind of purist ideal standards.  FriendlyRiverOtter (talk) 19:19, 8 December 2016 (UTC)
thread_title:  Only two of our references use the spelling 'ciclosporin' ? ? ?  

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thread_title:  External links modified 

message: "Restasis’s patents are under attack on two fronts, and moving the rights may shield them on one side. Last year, the drug -- which treats chronic dry eye -- brought in $1.49 billion in sales.
“I would expect it creates a playbook for other cases down the road both for us and for others,” Bob Bailey, Allergan’s chief legal officer, said of the agreement with the tribe."
https://www.bloomberg.com/news/articles/2017-09-09/casinos-aren-t-enough-as-native-tribe-makes-deal-on-drug-patents
--Wikipietime (talk) 15:47, 9 September 2017 (UTC)
thread_title:  Patent Attack and protection through Indian reservation. 

message: I propose that Optimmune be merged into Ciclosporin. There is not much information in the Optimmune, and it would be better explained in the context of the ciclosporin article in the "history" and other "veterinary use" sections. DferDaisy (talk) 20:30, 21 November 2018 (UTC)
replies: text: Yes and done. Doc James (talk · contribs · email) 21:34, 21 November 2018 (UTC)
thread_title:  Merger proposal: from [[Optimmune]]  

message: Also used for dogs with immune modulated hemolytic anemia 2600:1700:4E34:29A0:FD0E:5FE1:7982:98C8 (talk) 16:26, 5 March 2024 (UTC)
thread_title:  Veterinary use of ciclosporin