Talk:Germ cell tumor

message: These were references for testicular germ cell tumors, not attached to the text. They need to be checked and if useful cited in the article, else discarded. --Una Smith 01:43, 1 July 2007 (UTC)
thread_title: References

message: These pages have text overlapping with this page, and others;  distribute the text among other pages. --Una Smith 19:19, 1 July 2007 (UTC)
thread_title: Overlapping pages

message: moved here pending incorporation into this article, or deletion.  --Una Smith 22:39, 5 July 2007 (UTC)
thread_title:  text from [[germ cell ovarian cancer]] 

message: :Germ-cell tumors are classified as either seminomas or nonseminomas (which may be called teratomas in the UK). Seminomas are slow-growing.  Seminomas, when found, tend to be localized (i.e., only in the testicles), simply because they spread relatively slowly. Nonseminomas, on the other hand, tend to spread more quickly.  Nonseminomas are further classified into four subtypes; embryonal carcinomas, choriocarcinomas, yolk sac tumors, teratomas and mixed tumors. Their appearance under the microscope and also their gene expression is rather distinguished from each other, their rate of spread varies somewhat, but they are nevertheless treated similarly.  When seminomas and nonseminomas are both present (which is not unusual), the cancer is classified as nonseminoma.
:Blood markers for testicular tumors include the beta subunit of human chorionic gonadotropin (βhCG), lactate dehydrogenase (LDH), and alpha-fetoprotein (AFP). Seminomatous tumors never present elevated AFP levels.  Placental alkaline phosphatase and other markers are sometimes used by the pathologist to differentiate between seminoma and nonseminomatous tumors.
Most of the above text from testicular cancer duplicates text already here, but a phrase or two may be of use.  Integrate into the article, or delete. --Una Smith 16:07, 29 July 2007 (UTC)
replies: text: Most germ cell tumors have a chromosome count in the hypo to hyper triploid range (i.e. 60-70 chromosomes per cell nucleus in stead of the normal 46). About 80 % of these tumors also have a specific marker chromosome called isochromosome 12p. This is a chromosome where the shortest "arm" of chromosome 12 (12p) is present on both sides of the same centromer. Among germ cell tumors not having the isochromosome 12p, almost all have increased DNA copy number of 12p through other means. Thus, in tumors with unknown origin, increased DNA copy number of 12p is used as a marker for germ cell origin. The general gene expression patterns are clearly distinguishing the various histological subtypes of germ cell tumors. For example, in embryonal carcinomas, the same genes are overexpressed as are found highly expressed in embryonic stem cells. Further, AFP is a gene specifically expressed from yolk sac tumor, and CGB (encoding HCG) and other "pregnancy related genes" are specifically expressed from choriocarcinomas.
This text from testicular cancer needs to be rewritten (and cite sources!):  it applies primarily to post-pubescent testicular germ cell tumors;  these specific chromosome abnormalities usually do not occur in testicular germ cell tumors of babies and children, nor in post-pubescent germ cell tumors in other locations. --Una Smith 16:31, 29 July 2007 (UTC)
thread_title: cleanup text from [[testicular cancer]]

message: :Most germ cell tumors have a chromosome count in the hypo to hyper triploid range (i.e. 60-70 chromosomes per cell nucleus in stead of the normal 46). About 80 % of these tumors also have a specific marker chromosome called isochromosome 12p. This is a chromosome where the shortest "arm" of chromosome 12 (12p) is present on both sides of the same centromer. Among germ cell tumors not having the isochromosome 12p, almost all have increased DNA copy number of 12p through other means. Thus, in tumors with unknown origin, increased DNA copy number of 12p is used as a marker for germ cell origin. The general gene expression patterns are clearly distinguishing the various histological subtypes of germ cell tumors. For example, in embryonal carcinomas, the same genes are overexpressed as are found highly expressed in embryonic stem cells. Further, AFP is a gene specifically expressed from yolk sac tumor, and CGB (encoding HCG) and other "pregnancy related genes" are specifically expressed from choriocarcinomas.
This text from testicular cancer needs to be rewritten (and cite sources!):  it applies primarily to post-pubescent testicular germ cell tumors;  these specific chromosome abnormalities usually do not occur in testicular germ cell tumors of babies and children, nor in post-pubescent germ cell tumors in other locations. --Una Smith 16:31, 29 July 2007 (UTC)
thread_title: Genetics

message: Study Identifies Molecular Targets in Chemo-Resistant Germ Cell Tumors. Jan 2016 looks interesting but not sure where to mention it in the article. - Rod57 (talk) 14:13, 1 March 2016 (UTC)
thread_title:  Research on chemo-resistant GCT 

message: doi:10.1016/S0140-6736(15)00991-5 JFW | T@lk 13:14, 25 April 2016 (UTC)
thread_title:  Lancet review