lflage/wiki-talks huggingface dataset:
Talk:Fasoracetam

message: These following primary sources were trimmed and left the page looking @ deletion.
If any 2ndary sources could be found referencing these, please add them, they were:
*"Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer."
*"Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment."
*"A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture."
_Nagelfar (talk) 22:01, 13 March 2016 (UTC)
replies: text: I think that "http://adisinsight.springer.com/drugs/800003134" and the trials linked, are convincing and reliable sources. Redyaco (talk) 22:42, 20 March 2016 (UTC)
replies: text: That is a very thin reed to hang a lot of stuff on.  Where else is NFC-1 reliably identified as fasoracetam? Jytdog (talk) 00:29, 21 March 2016 (UTC)
replies: text:  At this webpage: https://clinicaltrials.gov/ct2/show/NCT02286817
 http://fdasis.nlm.nih.gov/srs/ProxyServlet?mergeData=true&objectHandle=DBMaint&APPLICATION_NAME=fdasrs&actionHandle=default&nextPage=jsp/srs/ResultScreen.jsp&TXTSUPERLISTID=42O8UF5CJB&QV1=42O8UF5CJB Redyaco (talk) 00:45, 21 March 2016 (UTC)
thread_title:  "Primary" sources 

message: User:Buddhafinder -- about:
* this 03:48, 27 May 2017 
* this 06:47, 1 June 2017
* this 04:41, 3 June 2017 
Please do read and follow WP:MEDRS. If you don't understand it, or understand why it has broad and deep consensus in the community, please ask. Thanks. Jytdog (talk) 06:00, 3 June 2017 (UTC)
replies: text: None of these sources are OK per MEDRS.  Again, please read MEDRS, and if you don't understand it, please ask. Thanks. Jytdog (talk) 19:15, 4 June 2017 (UTC)

text: Please don't generate content giving so much WEIGHT to primary source, and please avoid providing blow-by-blow WP:NOTNEWS content; we are an encyclopedia.  Thanks. Jytdog (talk) 23:10, 10 June 2017 (UTC)
replies: text: Good point about the blow-by-blow. I may want to put something back, but overall, I think you greatly improved the contribution. It is much less cluttered and more to the point.Buddhafinder (talk) 23:40, 10 June 2017 (UTC)
replies: text: Glad you find it acceptable. Jytdog (talk) 00:41, 11 June 2017 (UTC)
thread_title:  Clinical trial results
Talk:Hping

message: What is a "de facto tool" as used in the first part? Seems wrong to me. Volker Siegel (talk) 10:32, 18 June 2014 (UTC)
replies: text: In this case, I believe it means the tool has essentially become a reference implementation of a certain attacks.  Even if an argument were to be made that hping is obsolete now that nmap has more or less the same functionality, it's still of historical significance.  It's also referenced as the de facto tool by some CEH v9 prep material I've read, though I don't know how official that is.  —Zenexer [talk] 15:35, 27 May 2017 (UTC)
thread_title: Untitled
Talk:Fenfluramine

message: Is it correct to say increased 5HT 'depresses' CNS function? Increased seritonergic activity would not normally constitute a 'depressed' state. While 'depression' is a vague term, one usually associates it with reduced electrical or increased inhibitory neuron activity.
-Agreed, while the general result of serotonin release, or more specifically, activation of 5HT receptors is to reduce neuron firing, the word is far too vague and implies a sort of GABAnergic action that does not occur. —Preceding unsigned comment added by 81.129.111.90 (talk • contribs) 
I'm removing the brief clause that relate the two enantiomers of the molecule.  It doesn't communicate much and confuses a topic that is covered well under the chirality or enantiomer pages.  —Preceding unsigned comment added by 129.133.126.189 (talk) 01:52, 30 October 2007 (UTC)
thread_title: Section
Talk:Fine chemical

message: See User:PeterRPollak. --vuo (talk) 20:55, 11 December 2011 (UTC)
thread_title:  On the copypasted text 

message: Since this entire article is unsubstantiated assertions and is in places demonstrably license-violating copied text, I think we should consider deleting it altogether and let someone start from scratch if the article is truly needed, rather than trying to patch the existing skeleton into something defensible as an "encyclopedic" entry.
What do you think?
Riventree (talk) 14:14, 7 July 2021 (UTC)
thread_title: Delete article?

message: Added tag. Article has few references, almost all from 2009-2011. Most aren't online resources. I don't have the knowledge or energy to attempt improving it, but it seems to need a bit of work. Reads like it was written by one person and hasn't been changed much for about ten years.  — Preceding unsigned comment added by Champlax (talk • contribs) 12:24, 16 October 2021 (UTC)
thread_title:  Refimprove tag
Talk:First pass effect

message: Alternative routes of administration like suppository, intravenous, intramuscular, and sublingual avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.
How would a suppository bypass the hepatic portal? The inferior mesenteric vein serves the rectum. --70.131.113.133 (talk) 04:33, 24 September 2008 (UTC)
thread_title:  Oh Really? 

message: Also bypasses the FPE and goes into systemic circulation. Eg. oxybutinin patches, where conventional tablets cause significantly more adverse effects than the patches do.  — Preceding unsigned comment added by 220.239.41.11 (talk) 14:36, 4 May 2013 (UTC)
thread_title:  Transdermal route
Talk:Flibanserin

message: This article seems to be missing some info, since the adverse effects, especially when combined with alcohol, have been discussed as a serious concern about the drug.  I don't want to be too involved in this (conflict of interest) but there's more to be said about the adverse effects than the article currently includes.  166.176.187.184 (talk) 21:34, 21 August 2015 (UTC)
thread_title: Adverse effects

message: ... finds the evidence of low quality. doi:10.1001/jamainternmed.2015.8565 JFW | T@lk 08:59, 1 March 2016 (UTC)
thread_title:  Systematic review and meta-analysis 

message: I noticed above that in the last couple sentences of the first paragraph under "Activity Profile" (subsection of "Mechanism of Action" section), the article states that the norepinephrine-dopamine disinhibitor (NDDI) activity of flibanserin is the result of its activation of the 5HT1A receptor subtype. My own reading over time has seemed to indicate that the NDDI activity result from activity at 5HT2C. I'm wondering if this is just the result of a misreading of literature. It's also possible that the pharmacological understanding of the serotonin receptors has changed over the years to clarify these receptor differences.  — Preceding unsigned comment added by 173.18.57.162 (talk) 22:22, 30 October 2016 (UTC)
thread_title:  Identification of 5-HT<sub>1A</sub> receptor source of NDDI activity 

message: https://www.bbc.co.uk/news/world-middle-east-46877038
The notable parts for me are:
* Locally produced.
* Over the counter.
* Culture - men are in the main part the purchasers and are happy to do so even after being warned of side effects. "Murad Sadiq, who runs a pharmacy in northern Cairo, says he always explains the side effects to customers but that "they still insist on buying it". "About 10 people a day come in to buy the drug. Most of them are men. Women are too shy to ask for it." — Preceding unsigned comment added by 128.40.214.250 (talk) 10:15, 18 January 2019 (UTC)
thread_title:  BBC News article on this in Egypt
Talk:Fludiazepam

message: I have no sources to prove it but my gut feeling is the dosage is wrong. 
a) 1,4 benzodiazepines stronger than 1mg ~ 10mg diazepam
b) the replacing the r2' hydrogen with chlorine or fluorine and the r7 Chlorine with a nitro group or bromine and the n-1 hydrogen with a methyl group tends to give the strongest compounds but even these are only about 10x the potency of diazepam (flunitrazepam, n-methyl clonazepam, n-methyl phenazepam)
c) this one claims to be 40x as strong as diazepam which would make it one of the strongest benzodiazepines (which are all triazolobenzodiazepines)
d) norflurazepam (or n-desmethylfludiazepam) is available on the grey market and is only around 2x the potency of diazepam
e) I would guess fludiazepam is about 2.5mg ~ 10mg diazepam
f) does anyone have any other sources confirming that 0.25mg ~ 10mg diazepam?  — Preceding unsigned comment added by 2A00:EE2:600:900:4906:E8D4:8B47:F397 (talk) 00:11, 23 March 2016 (UTC)
Talk:Flumazenil

message: This stuff probably causes brutal anxiety in many people. Benzo withdrawal itself causes nightmarish anxiety, with episodes of panic, which can persist for months. I suspect Flumazenil would make it worse in many cases. A benzo-induced coma is not a good thing, certainly. Waking up from a coma into an all-out panic attack would be really bad, and would present patient management problems of its own.
Years ago, I read of some kind of benzo antagonist being used by Soviet authorities on political dissidents, in psychiatric hospitals, as a torture method. Ugly.
There's plenty of medical evidence for this problem. Just google "Flumazenil (anxiety OR panic)" without the quotes.
This article should mention some of these issues. 69.110.107.45 (talk) 00:50, 11 October 2013 (UTC)
thread_title:  Anxiety 

message: This page states (in the introduction) that Flumazenil is an antagonist of the GABAa receptor.  This is technically incorrect.  An antagonist of the GABAa receptor would prevent GABA from activating the receptor, while Flumazenil has no effect on GABA binding or activity.  
I think the most accurate classification for Flumazenil is a silent allosteric modulator of the GABAa receptor, as it only affects the binding of compounds to the BZD site without affecting activity otherwise.  — Preceding unsigned comment added by 141.214.17.201 (talk) 20:57, 13 October 2013 (UTC)
thread_title: Silent Allosteric Modulator

message: Hey,
shouldn't the IUPAC name be Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate? --PolynomialHelix (talk) 02:42, 4 November 2014 (UTC)
thread_title:  IUPAC Name 

message: The article would be better understood if the reader was provided a link that explains what up and down regulation mean.  — Preceding unsigned comment added by 172.78.76.206 (talk) 02:42, 27 April 2016 (UTC)
thread_title:  There should be a link to the "Downregulation and upregulation"

message: Hi!
I suspect that this edit might be a sneaky bit of vandalism. What are your thoughts? Is otic flumazenil administration really a thing?
Regards, TealHill (talk) 07:28, 21 July 2020 (UTC)
thread_title:  Possible sneaky vandalism
Talk:List of American Solheim Cup golfers

message: Howdy - I am working on compiling the data for all the Solheim Cups; once done, I should be able to semi-automatically generate tables for this page and for the individual players.  If anyone is doing anything similar, please let me know so there's not a lot of duplicated effort :) So far it will take the results from each individual's events and compile an array with their name, their win/loss/half for each event, their total, total points, and overall percentage.  DukeEGR93 22:23, 23 August 2009 (UTC)
thread_title:  Data Set Additions 
Talk:Flurbiprofen

message: Attention! The structure of flurbiprofen on this page is incorrect! Position of fluorine in aromatic ring is wrong! If you can rewrite the image, make it, please...  —Preceding unsigned comment added by 195.91.144.210 (talk) 20:51, 12 November 2007 (UTC)
replies: text: The image appear to be correct now.  -- Ed (Edgar181) 15:49, 27 January 2008 (UTC)
thread_title: structure

message: According to this, melting point of flurbiprofen is 117 °C. If it's correct, put it in article--CERminator (talk) 10:28, 20 June 2008 (UTC)
thread_title: Melting point

message: — Assignment last updated by JustinxLane (talk) 19:04, 2 June 2023 (UTC)
thread_title: Wiki Education assignment: PHMD 2040 Service - Learning Spring 2023
Talk:Fortisip

message: This article reads more like an advertisement than an encyclopedia article e.g. in the first sentence the word "palatable" jumps off the page - a subjective judgement, surely? Also there are no references to external 3rd party sources. IMO this article is a candidate for deletion - if I could remember how, I'd tag it as such! Perhaps someone else can help. Thanks. --TraceyR (talk) 21:07, 14 March 2008 (UTC)
replies: text: I have added 'fact' tags to two statement which are lifted directly from the product label/pdf data sheet without external verification. --TraceyR (talk) 09:09, 15 March 2008 (UTC)
thread_title:  Advertising blurb? 

message: I have removed this article from WikiProject Pharmacology. "Nutritional supplements" != "Pharmaceuticals". Dr. Cash (talk) 21:31, 14 March 2008 (UTC)
thread_title: Removal from [[WP:PHARM]]

message: The article (and the company literature, from which much of it has been copied) state that "Fortisip is suitable for use as the sole source of nutrition (my emphasis) for most people over 6 years of age." I have raised the need for citation(s) supporting this statement, but is there any way in which this could be true? The company presumably takes legal advice about the claims it makes for the product, but it sounds way over the top to me. It could even be seen as dangerous advice for the general public and might cause Wikipedia problems - just imagine what would happen if comeone took this seriously. Any comments? --TraceyR (talk) 11:44, 16 March 2008 (UTC)
replies: text: I can only add a personal anecdote to this - whilst my uncle was suffering from terminal stomach cancer, this was basically all that was keeping him alive, as his system couldn't handle much more than two or three of these a day and some water. So yes. As it's a doctor-prescribed item in such cases, one hopes their claims are truthful. The relevant health authorities (particularly in my country) wouldn't allow its use otherwise. 77.102.101.220 (talk) 22:20, 8 August 2010 (UTC)
thread_title:  "Suitable as the sole source of nutrition" - OTT? 

message: More like Frostipis, am I right? Hahahahaha --89.127.175.172 (talk) 00:24, 15 September 2009 (UTC)
replies: text: nice anagram, but you're a letter over.  —Preceding unsigned comment added by 77.102.101.220 (talk) 22:21, 8 August 2010 (UTC)
thread_title:  Fortisip 

message: The advertisement ("article") makes extraordinary claims, with no evidence at all supporting these claims. Where are the peer-reviewed papers published in a relevant science journal that suggests this malnutrition supplement has any kine of efficacy? Desertphile (talk) 20:29, 24 May 2023 (UTC)
thread_title:  Evidence Required
Talk:Fosamprenavir

message: What configuration does the C which carries the benzyle group have? 131.220.136.195 12:29, 15 March 2007 (UTC)
replies: text: Seems to have been added meanwhile. --ἀνυπόδητος (talk) 08:56, 9 April 2012 (UTC)
thread_title: Stereochemistry

message: Putting the crystal structure of amprenavir instead of fosamprenavir is ill advised.  — Preceding unsigned comment added by CA40102882 (talk • contribs) 11:38, 5 November 2017 (UTC)
replies: text: Why? Fosamprenavir is hydrolyzed to amprenavir, which subsequently binds to HIV protease. --ἀνυπόδητος (talk) 09:51, 13 November 2017 (UTC)
thread_title: Crystal Structure
Talk:Fosfluconazole

message: Is it a phosphonic acid or phosphoric acid? Can someone please clarify? --kupirijo (talk) 09:59, 23 March 2010 (UTC)
replies: text: OK. I see why it is phosphonic. It actually says oxophosphonic = phosphoric. --kupirijo (talk) 11:23, 26 March 2010 (UTC)
thread_title:  phosphonic acid vs phosphoric acid
Talk:Bletchingley

message: I agree with User talk:Pontificake and have also deleted this link  The Caterham Link.  It is just an advert for local services and does not give any encylopedic info.  It was put in non-surprisingly by User talk:Caterhamlink SuzanneKn 19:22, 1 March 2007 (UTC)
thread_title: Caterham link website
Talk:Fulvestrant

message: The patent extension seems to be an issue. 
This isn't a WP:RS, but it has some useful links. http://patentcircle.blogspot.com/2006/11/fulvestrant-expiring-in-december-2007.html --Nbauman (talk) 19:05, 16 January 2012 (UTC)
thread_title:  Patent extension 

message: There seems to be some evidence (such as http://www.ncbi.nlm.nih.gov/pubmed/15764600) that fulvestrant can actually act as an agonist for certain membrane bound estrogen receptors - what are the thoughts on including this in the article?  — Preceding unsigned comment added by Rpzrz (talk • contribs) 12:04, 23 October 2014 (UTC)
thread_title:  Fulvestrant as an estrogen membrane receptor agonist
Talk:Takeshi Honda (animator)

message: References comming up. --GunnarRene 19:23, 1 March 2007 (UTC)
thread_title: Refs coming

message: There are many more credits to be added to the filmography, and there are also video games. --GunnarRene 19:52, 1 March 2007 (UTC)
thread_title:  Expansion 

message: As noted by several published references, sources and resources, the subject is most certainly a highly notable individual, and passes Wikipedia:Notability extremely comfortably; see the Anime News Network entry, the allcinema.net and Hate na Diary entries, for example. The Japanese Wikipedia article is also quite well detailed. ···巌流? · Talk to Ganryuu 23:31, 1 March 2007 (UTC)
thread_title: References
Talk:Gadodiamide

message: Take note that Omniscan is also the name of a proprietary book scanning software program. Thus, an article for this version should be created, and a disambiguation page to go along with it. I'm just not that ambitious. The Google Book Search team uses Omniscan to clean up page scans of books.  —Preceding unsigned comment added by 38.97.70.151 (talk) 06:12, 26 April 2008 (UTC)
Talk:Gadopentetic acid

message: The new structure is fine, but it is not that of gadopentetic acid. Maybe the title need to be changed to "Gadopentate"? The chemical formula C28 ... is that of the dimeglumine salt. I have not checked the other items in the drugbox to see if they refer to the acid or the salt; consistency is needed. Petergans (talk) 13:51, 21 November 2011 (UTC)
thread_title:  Title 

message: The molecular weight was correct as it was before, as 545.56. The pubchem link referenced is not for gadopentetic acid. It is for the dimeglumine salt.
— Preceding unsigned comment added by 170.223.137.116 (talk) 14:26, 31 May 2017 (UTC)
thread_title:  Wrong molecular weight?
Talk:Ilgachuz Range

message: I almost just pulled "unique", it's such an over-used verb, but the subsequent sentence:
:The range supports a unique grassland ecosystem. This type of grassland has not been seen anywhere else in central and southern British Columbia. 
...promptos me to leave "unique" there for now, and to ask what type of grassland; I've seen such claims about other biomes, particularly the so-called desert at Osoyoos, but also in ref to wet biomes and so on.  So if this is going to be said, thet nature of the grassland has to be specified, and what makes it "more unique" than other "unique" grasslands......Skookum1 (talk) 15:00, 14 September 2008 (UTC)
replies: text: I agree with your suggestions. This article should also mention the shape of the range since it seems to look more like a massif than an actual mountain range. The Itcha Range has a similar appearance as well. Black Tusk (talk) 22:30, 17 October 2008 (UTC)
thread_title:  "Unique" grassland 
Talk:GI cocktail

message: My plan is to improve the article is as follows:
Lead Section: Rework the lead section to define the topic and provide a concise overview of the GI cocktail. This includes adding to the introductory sentence and including a brief description of the article’s major sections (described under “Content”). 
Content: I plan to add up-to-date information regarding conditions for which the GI cocktail has been used, side effects of the GI cocktail, and addressing studies that claim the GI cocktail is no more effective than an antacid alone. 
Tone and Balance: Maintain a neutral point of view while reworking the article and providing additional information regarding the GI cocktail. 
Sources and References: Expand upon sources and references already provided in the article by providing ones that are more current and up-to-date. Additionally, using resources from peer-reviewed articles, medical journals, etc. 
Organization and Writing Quality: Maintain a clear and professional tone throughout while keeping the article concise, clear, and easy to read.
Images and Media: If applicable, provide images and media that enhance understanding of the GI cocktail
Amahaja1 (talk) 01:04, 7 March 2022 (UTC)
thread_title:  Work Plan
Talk:Gidazepam

message: If someone would care to draw up the synthesis, it can be found:
http://www.bioorganica.org.ua/UBAdenovo/pubs_5_1_07/Golovenko_2007_1.pdf  — Preceding unsigned comment added by 86.30.243.179 (talk) 20:47, 3 July 2012 (UTC)
thread_title: Synthesis
Talk:Gliclazide

message: Most articles I've read show it as being a second generation sulfonylurea. However, there is the one reference that shows it as a first generation. Can anybody offer any clarity on the generation of gliclazide? Perhaps there was a change in generation, or it has properties of both generations?- ellusion - (talk) 12:57, 9 November 2009 (UTC)
replies: text: Second gen, see source given in 3 April 2017 Talk entry. Leprof 7272 (talk) 07:50, 3 April 2017 (UTC)
thread_title:  Generational status 

message: Sold as Diamicron and Glyade in Australia (and elsewhere?) 122.107.58.27 (talk) 23:47, 2 April 2010 (UTC)
thread_title:  Other names 

message: …generally or specifically, especially as this is an apparent positive distinctive attribute of this particular second gen compound. For a starting point, see here. Le Prof Leprof 7272 (talk) 07:50, 3 April 2017 (UTC)
thread_title: Why no mention re: the sulfonylurea CV safety issue

message: Should the sentence saying a medication is not sold in the United States be there?  
Firstly, that is a null report. Shouldn't an article say where it is sold, rather than where it isn't? 
Secondly, I suspect it isn't sold in some other countries, but only the United States is mentioned.   If the drug has been explicitly banned by American regulators, that would be a reasonable comment. Humphrey Tribble (talk) 21:14, 8 April 2022 (UTC)
thread_title:  Globalize / undue emphasis? 

message: — Assignment last updated by JustinxLane (talk) 19:04, 2 June 2023 (UTC)
thread_title: Wiki Education assignment: PHMD 2040 Service - Learning Spring 2023
Talk:Glimepiride

message: This article is half gibberish and half broken english. Someone who actually understands this needs to fix it. AeoniosHaplo 19:16, 18 May 2007 (UTC)
thread_title:  What? 

message: What's the biological half-life?  The article says it's 5 hours.  My primary care physician said it's closer to 9-10 hours.  I think the article could be improved with a citation to appropriate research -- especially if 5 hours is wrong.  I understand that the reality could be more complicated than simple exponential decay.  Glimepiride might go through several stages in the body, and the ingested form might have a half-life of 5 hours but half of a subsequent form could still be present 10 hours later.  Thanks, DavidMCEddy (talk) 22:39, 30 September 2015 (UTC)
thread_title:  Half-life
Talk:Glycoconjugate

message: *I have straightened out the relation between glycoconjugates and glycosides, and I have removed the merger suggestion. 
From a biochemical viewpoint the merger suggestion did not make any sense. Drlectin (talk) 23:40, 24 December 2012 (UTC)

message: I would like to put forward the creation of a new category i.e. :Category:Glycoconjugate. --kupirijo (talk) 12:17, 18 November 2020 (UTC)
thread_title:  New category '''Category:Glycoconjugate'''