Talk:PANDAS

message: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a clinical diagnosis given to children who experience a rapid, acute onset neuropsychiatric symptoms, including symptoms of obsessions/compulsions and tics  . While it may appear based on the symptomology that the individual has obsessive-compulsive disorder (OCD) or tic disorders, the sudden onset of symptoms separates PANDAS from those other disorders. While the scientific causes of PANDAS is not completely understood yet, symptoms are proposed to be caused by group A streptococcal (GAS), and more specifically, group A beta-hemolytic streptococcal (GABHS) infections.[3] OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post-streptococcal autoimmune process.[4][5][6] The proposed link between infection and these disorders is that an autoimmune reaction to infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations, and this autoimmune response results in a broad range of neuropsychiatric symptoms.[3] Meadows95 (talk) 18:07, 24 December 2023 (UTC)
replies: text: Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Deltaspace42 (talk • contribs) 21:51, 24 December 2023 (UTC)
thread_title:  Semi-protected edit request on 24 December 2023 

message: One reads this article with the impression that there is absolutely no good reason to entertain that PANDAS exists. It speaks to the controversial nature of the subject matter but fails to be neutral. It's obvious the main author thinks the condition is a blanket diagnosis that is overused and has little merit.
The article ends with: "As of 2020, the NIH information pages (which Swedo helped write) do not mention the studies that do not support the PANDAS hypothesis." This line verbatim is used in Dr. Swedo's wikipedia page. 
I think the same charge could be leveled at the principal keeper of this article. 
Using the phrase, "As of 2021, the autoimmune hypothesis of PANDAS is not supported by evidence" Is not an accurate statement. Perhaps, the evidence is not to the level that is needed for definitive proof, or to martial a broad scientific consensus but to imply that there is no evidence or any evidence in general that could suggest a connection to an autoimmune response is flat out wrong and shows the level of bias in this article. 
Here is one recent review that gives a more neutral overview of scholarly conversations, studies , investigations being had: 
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Myth or Reality? The State of the Art on a Controversial Disease
PMID: 37894207
 
PMCID: PMC10609001
 
DOI: 10.3390/microorganisms11102549
Yes, there are conflicting findings, and the studies are of various kinds, but speak to the conflicting evidence. Don't say, "no evidence." Factfinder2024 (talk) 20:33, 7 February 2024 (UTC)
thread_title:  Scientific update needed  -- Article not neutral   

message: Vreeland, A., D. Calaprice, N. Or-Geva, R. E. Frye, D. Agalliu, H. M. Lachman, C. Pittenger, S. Pallanti, K. Williams, M. Ma, M. Thienemann, A. Gagliano, E. Mellins & J. Frankovich (2023). Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder. Developmental Neuroscience 45(6), 361-374. DOI: 10.1159/000534261.
 Gagliano, A., A. Carta, M. G. Tanca & S. Sotgiu (2023). Pediatric Acute-Onset Neuropsychiatric Syndrome: Current Perspectives. Neuropsychiatric Disease and Treatment 19, 1221-1250. DOI: 10.2147/NDT.S362202.
 Franklin, M. E., S. Eken & E. Osterlund (2023). Current Research Updates on PANDAS and PANS. Current Developmental Disorders Reports 10(4), 264-273. DOI: 10.1007/s40474-023-00280-w.
Time for a re-write of this wiki page. Sirdragos (talk) 10:41, 7 March 2024 (UTC)
thread_title:  Additional PANS/PANDAS reviews (i.e. non primary), 2023 update