lflage/wiki-talks huggingface dataset:
Talk:Golimumab

message: EULAR: IV Golimumab Succeeds in AS 2017  says intravenous injection also approved for RA, and being trialled for AS. (The IV dosing is 2mg/kg every 8 weeks (vs 50mg/month for subcutaneous) so maybe there are adverse reactions to subcutaneous injections.) - Rod57 (talk) 07:21, 22 June 2017 (UTC)
thread_title:  IV also approved and being trialled 

message: This Wikipedia entry states that:
"National Institutes for Health and Care Excellence (NICE) stated that treatment with golimumab is not recommended for RA patients who have failed prior TNFi treatment"
However, upon checking the quoted reference (doi:10.1007/s40273-013-0052-7), its last sentece states:
"The Appraisal Committee concluded that golimumab should be recommended in combination with methotrexate as an option for patients with severe active RA who have failed on conventional DMARDs, or who have failed on a TNF-α inhibitor and are contraindicated to or withdrawn from rituximab."
''
[both emphases added]
So while Wikpedia recommends against using this kind of TNFi when other failed, the NICE meta-analysis states that it's a fair try in combination with MTX.
I have a PhD in biochemistry so I think I am able to read the abstract of a scientific paper and understand it (I don't have full access to the paper and am not willing to shell $50 to read it in full). Am I missing something, or should the entry be revised?
79.243.58.106 (talk) 07:05, 19 October 2018 (UTC)
thread_title:  Recommended or not for patients who failed other TNFi treatments?
Talk:Griseofulvin

message: 1. For fungal infections of nails
2. For fungal infections of hairy areas, such as scalp, axilla, groin
3. When topical antifungals fail, then for fungal infections of non-hairy areas of skin
Sbelknap (talk) 02:49, 25 November 2018 (UTC)
replies: text: Simplified some. Doc James (talk · contribs · email) 13:47, 25 November 2018 (UTC)
replies: text: Hi, this is not clear. References of drug for Onychomycosis please. According to https://www.dermnetnz.org/topics/griseofulvin/: "For many fungal infections, especially of the nail (tinea unguium), newer drugs work better than griseofulvin. Griseofulvin may still be preferable for tinea capitis, especially when due to Microsporum canis infection, and is generally well tolerated in children." KR 17387349L8764 (talk) 19:41, 10 May 2021 (UTC)
thread_title:  Indications where evidence supports use of Griseofulvin
Talk:Guggulsterone

message: That the statement "Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone" is wrong can be seen from the reference below, but I do not have enough information to make a correction. In http://www.herbalprovider.com/guggul.html?src=ggl&w=guggulsterone-sale&gclid=CO7juK7M0a8CFYe5KgodpBDwGw under supplement facts I read "Guggul Gold™ Standardized Extract Commiphora mukul [gum resin] standardized to contain 10% total Guggulsterones (50 mg) and 2.5% Guggulsterones Z & E (12.5 mg)" so only 25% of the guggulsterone is if type Z or E. 128.210.124.27 (talk) 05:59, 26 April 2012 (UTC)
thread_title:  Error in description
Talk:Halazepam

message: The drug is no longer marketed in the United States, and a 25 year old reference as a source that the drug is effective in the treatment of anxiety seem to contradict each other. What's the story? User:Fred Bauder Talk 23:13, 10 December 2014 (UTC)
thread_title: Contradictions

message: The drug was available in Spain but seems to no longer be available http://www.doctoralia.es/medicamento/alapryl-3585/foro/dejar-alapryl-por-uno-equivalente-31087 the other name was used in Portugal. User:Fred Bauder Talk 15:11, 11 December 2014 (UTC)
thread_title: Availability
Talk:Jyongri

message: edited to conform to Wikipedia:Manual of Style (Japan-related articles) Brettr 09:41, 27 May 2007 (UTC)
thread_title:  caps 

message: I've looked for her name in kanji but can't find it. Perhaps she isn't Japanese but zainichi Korean? I can't find anything that mentions this either way. Brettr 10:47, 24 June 2007 (UTC)
thread_title:  name 
Talk:Khong Island

message: 55,000 inhabitans? In the whole district, but not only on the island...  — Preceding unsigned comment added by 101.78.10.1 (talk) 17:29, 6 March 2014 (UTC)

message: One of the two photos talks about Don Khon (that's another island) and the other one is almost sure also not Don Khong. It is also not a village on the photos.  — Preceding unsigned comment added by 103.1.31.106 (talk) 10:09, 12 July 2020 (UTC)
replies: text: The first picture was Don Khon. Second image removed too. Thanks -- Basile Morin (talk) 13:33, 30 July 2020 (UTC)
thread_title:  Photos wrong
Talk:Heptaminol

message: Why? Looks much more like a vasoconstricor. --FK1954 (talk) 16:48, 5 February 2011 (UTC)
replies: text: No, it's a coronary vasodilator. The error is that it's not used to treat hypotension but hypertension and it's mainly for veterinary use.  — Preceding unsigned comment added by Usermarco (talk • contribs) 08:45, 16 May 2013 (UTC)
thread_title:  Vasodilator
Talk:Homatropine

message: Homatropine methyl bromide is a separate entity. It is a quaternary ammonium salt, does not cross blood-brain barrier, has no central effect and has different indication from homatropine hydrobromide, the teriary compound.
The drugbox links to the wrong picture namely the homatropine methylbromide, not the hydrobromide which is named in the drugbox.
The quaternary compound needs a separate entry in Wikipedia. The situation is like with scopolamine butylbromide alias butylscopolamine bromide (Buscopan) which is also completely separate entity from scopolamine, has no central action and has different indications than scopolamine. This needs to be fixed.
70.137.149.219 (talk) 01:51, 3 July 2011 (UTC)
thread_title: Homatropine methyl bromide
Talk:Moses Horowitz

message: According to :
Moyshe Hurvits (Moses Hurwitz) is mentioned in Nahma Sandrow's history of the Yiddish theater, "Vagabond Stars," and in David Lifson's book, "The Yiddish Theater in America."  There is quite an extensive entry on him in the "Leksikon fun yidishn teater" (Lexicon of the Yiddish theatre), by Zalmen Zilbertsvayg (Zylbercweig; vol. 1, cols. 591-606).
That last "extensive" source would presumably be in Yiddish, if anyone can hack that.
- Jmabel | Talk 19:43, 1 March 2007 (UTC)
thread_title: Possible sources
Talk:John Hallett

message: Converted from a redirect to a human name disambiguation page. Clarityfiend (talk) 06:02, 8 May 2021 (UTC)
thread_title:  Update 

message: John Hallett was believed to have been born in 1772, which would have made him fifteen when he signed on the Bounty, and seventeen at the time of the mutiny, the same as Midshipman Peter Heywood, who was also fifteen at signing and seventeen at the time of the mutiny. James Galloway (talk) 23:53, 13 November 2012 (UTC)
thread_title:  Age
Talk:Francis Bridgeman (Royal Navy officer)

message: Thanks for the move back to the old Dab'g sufx: "Royal Navy officer", while it presumably applies better to the whole of his career, is unnecessarily wordy. And even if there is only one Royal Navy left, it's abusive to expect users to know which one is intended.--Jerzy•t 17:39, 3 March 2007 (UTC)
thread_title:  Title 
Talk:John Kerans

message: *Is this the John Kerans who proposed "mercy killing" the kids disabled by thalidomide? Dysmorodrepanis 17:18, 5 September 2007 (UTC)
thread_title:  Thalidomide scandal? 
Talk:4-Hydroxyamphetamine

message: There are a few compounds that could be called hydroxyamphetamine. How about moving to 4-Hydroxyamphetamine or p-Hydroxyamphetamine?--Eloil 12:04, 6 April 2007 (UTC)
thread_title:  Rename? 

message: I reverted some content in this dif b/c it is from a primary source and  just reverted in this this dif with edit note, "bindingdb isn't a primary source; it's a Ki database".
All of WP's policies and guidelines point us to using secondary sources for WP content - the reasons for this are many.   A big one, in my view, is that our goal here is to provide meaningful information to readers. We are not a technical manual nor an indiscriminate collection of factoids.  Secondary sources provide context and weight.   
I've been removing contribs from  which has led me into a lot of chemistry-based articles, and I keep finding random collections of facts, without context.  I don't understand the ethos/culture of the editing community on these articles.   So this seems a good time to ask - why does it matter  that this drug is "an agonist of human TAAR1"? (real question - and please don't answer with a general hand-wavy thing like "knowing activities of drugs is a good thing!  I know that)  Really importantly, it is not like the article is currently attempting to give a complete binding profile for this drug.  The implication here is that that TAAR1 is the only protein affected by this drug, which is not true ( as far as I know).  This is one random association. 
So, per not a technical manual nor an indiscriminate collection of factoids and the sourcing (and I hold that a database is a primary source!) this content shouldn't be in WP.  Interested to hear responses! Jytdog (talk) 12:27, 12 November 2014 (UTC)
replies: text: Uhm...I'm not exactly sure what kind of answer you're looking for, but I'll just give you the functional one.  Every substituted amphetamine that effectively produces neurotransmitter efflux has, at bare minimum, two properties in common: it binds to vesicular monoamine transporter 2 and functions as a TAAR1 agonist.  That receptor's activation completely changes the dynamics of neurotransmitter release in the axon terminal of monoamine neurons.  TAAR1 activation is the defining feature of trace amines and most substituted amphetamines.  The significance of that sentence is self-apparent to those who know about the receptor's function in the CNS. Seppi333 (Insert 2¢ | Maintained) 12:44, 12 November 2014 (UTC)

text: thanks for talking. your answer shows part of the problem.   we don't include content based on "the significance is apparent to those who know" right?  again this is the problem with using WP:PRIMARY sources.  i'll look for sources to improve this article - i'm just bitching.   Jytdog (talk) 14:34, 12 November 2014 (UTC)
thread_title:  secondary sources
Talk:Hydroxychloroquine

message: 17.000 deaths in just 6 countries attributable to hydroxychloroquine: https://www.sciencedirect.com/science/article/pii/S075333222301853X
See also https://www.sudouest.fr/sante/coronavirus/covid-19-selon-une-etude-l-hydroxychloroquine-serait-responsable-de-pres-de-17-000-morts-dont-199-en-france-18011353.php (in French). --Randykitty (talk) 09:37, 6 January 2024 (UTC)
thread_title:  17.000 killed 

message: Change "Neither drug prevents SARS-CoV-2 infection." to "Neither drug has been useful to prevent or treat SARS-CoV-2 infection."
Add reference to Cochrane review: Singh B, Ryan H, Kredo T, Chaplin M, Fletcher T. Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19. Cochrane Database of Systematic Reviews 2021, Issue 2. Art. No.: CD013587. DOI: 10.1002/14651858.CD013587.pub2. Tkesteman (talk) 03:54, 27 February 2024 (UTC)
replies: text: ARandomName123 (talk)Ping me!  16:13, 27 February 2024 (UTC)
thread_title:  Extended-confirmed-protected edit request on 27 February 2024
Talk:Hydroxytropacocaine

message: Besides E. coca, 1-hydroxytropacocaine I've heard on respectable authority to be found in E. Novogranatense as you can cf. N.B. (source) Nagelfar (talk) 17:45, 23 July 2017 (UTC)
thread_title:  also an alkloid in ''E. Novogranatense''(?)
Talk:Paws & Tales

message: It is almost two months since I attempted to have this article WP:PRODed, and still there is no sources (let alone third party sources demonstrating significant coverage), no assertion of notability, and little but unencyclopaedic 'in universe' content. Any reason why I shouldn't AfD it? HrafnTalkStalk(P) 09:11, 1 March 2009 (UTC)
replies: text: Because I'm tired of being the article rescuer. *shrug* I'll get to it tomorrow. You may AFD is you want, but I plan to work on it. TheAE talk/sign 09:18, 1 March 2009 (UTC)

text: *Colonel Warden: no indication of notability, nothing but unencyclopaedic WP:FANCRUFT, so why the hades should I want to make it 'my problem'? You have just demonstrated that you you can find an obscure and rather marginal source for the most trivial and banal statement in the article: "Paws & Tales is a Christian production for children by Insight for Living and Chuck Swindoll" -- that does next to nothing to raise it to wikipedia standards. HrafnTalkStalk(P) 10:23, 1 March 2009 (UTC)

text: Why are we still having this discussion?  There's always room for improvement, but there ARE sources listed, and a lot better than the average Wikipedia article.   The issue of notability has been addressed: 450 outlets plus untold internet listeners is pretty wide coverage, not to mention the animated series, especially considering that Wikipedia maintains articles on single characters, or complete episode lists and synopses out of other story arcs of comparable notability. -Blueguy 65.0.221.140 (talk) 21:24, 26 September 2009 (UTC)
replies: text: (i)We're not "still having this discussion" -- the above is 6 months old. (ii) The sourcing (which only covers the first paragraph) is at best highly marginal -- to the book that it is based on, their producer, a puff piece in the Oklahoma Baptist Messenger, and a couple of bare "announcements" of the videos' existence. HrafnTalkStalk(P) 03:10, 27 September 2009 (UTC)
thread_title:  No sources, no notability, no encyclopaedic content 

message: According to Insight for Living, they do not have the funds to continue the series and therefore there are no plans to do so. 2601:603:401:7230:0:0:0:F43E (talk) 03:58, 19 June 2022 (UTC)
thread_title:  Continuing the Series
Talk:Ibandronic acid

message: How does this cause bone density to increase (as per advertisements in the US)?  —Preceding unsigned comment added by KyNephi (talk • contribs) 18:31, 30 October 2007 (UTC)
replies: text: Have a look at Bisphosphonate#Nitrogenous. Best, Fvasconcellos (t·c) 18:41, 30 October 2007 (UTC)
thread_title:  How does it work? 

message: Is this article being sanitized or astroturfed?  The most prominent brand names and some related links and category information have been disappearing.--Stageivsupporter (talk) 02:03, 9 August 2013 (UTC)
thread_title: bias?

message: This drug has had several national commercials for law firms collecting for clients who have taken Boniva. Why is there no mention about the damage this has done to Sally Field's career, since she was the spokeswoman for the drug in its commercials?Taric25 (talk) 17:25, 21 December 2014 (UTC)
thread_title:  Sally Field
Talk:Ibutilide

message: I am not familiar on how to use the wiki user interface. Hope someone could fix the reference for me.
--Wolingfeng 02:40, 4 October 2007 (UTC)
replies: text: Done :) Wikipedia:Footnotes provides information on Wiki's reference formatting—it's easy, once you get the hang of it. I'd also like to note that Wikipedia doesn't usually provide a separate "Patient information" section; ideally, that information should be integrated into the article, and most of the article (if not the whole article) should be understandable to the average reader. Fvasconcellos (t·c) 03:39, 4 October 2007 (UTC)
Talk:Lawrence E. Knox

message: Grandfather's biography may have been renamed from "Laurence" to "Lawrence", as we have many links to the redirect .
Our cited sources National University of Ireland uses "Laurence E. Knox" .
Both given names may be useful to search in digital sources. --P64 (talk) 01:26, 10 May 2019 (UTC)
thread_title:  Laurence or Lawrence 

message: The Irish Times has published in the 21st century at least one other article on its founder, beside the one we cite, which is a version of his Dictionary of Irish Biography entry (2009). Namely:
* Peter Murtagh, 02 Jan 2010: B6, "An Irishman's diary from Crimea: The daily routines of the Crimean War are brought to life with the discovery this year of a Victorian-era diary that belonged to Lawrence Knox, soldier and founder of The Irish Times"
By the way, it reports that he signed the front piece of his diary "LE Knox". --P64 (talk) 01:35, 10 May 2019 (UTC)
thread_title:  ''An Irishman's diary from Crimea''
Talk:Imiglucerase

message: Removed unhelpful reference to cost-per-mg. Reasons: (i) Dosage is in IU, not mg. Cost per IU might have been useful; cost per mg is not. (ii) As a general indicator of expense, we already have a far-more-informative statement about the typical cost per patient per year. (iii) Source of this information not cited; format of stated cost ("for a 40kg patient, $3m per mg of enzyme") indicates that this may have been reverse-calculated from the typical cost per year, a hypothesised patient mass, and the molecular weight of the drug, and hence is not a reliable figure. (Cost per mg of enzyme does not exhibit any dependence on patient weight!)
Action: Removed spurious sentence. Added link to article "orphan drug" to provide background on government incentives for the development of unprofitable, but life-changing, medications for rare diseases.
R. Pfeifer, 58.96.54.100 (talk) 11:02, 4 March 2011 (UTC)
thread_title: Untitled
Talk:Antyradio

message: PL: dopiszcie jeszcze co sie da :)
Może nie powinno w artykule być polskich znaków? A nazwy miast - mają być "angielskie"?  —Preceding unsigned comment added by 83.7.191.172 (talk) 21:11, 16 February 2008 (UTC)
thread_title: Untitled
Talk:Amos Kloner

message: From Wikipedia:Notability (academics)'s criteria for notability:
"1.An academic who has published a book or books of general interest, a widely used textbook, or non-academic articles in periodicals with significant readership is likely to be notable as an author (see WP:BIO), regardless of their academic achievements. Similarly, an academic involved in significant current events is likely to be notable as a person under the general WP:BIO guidelines.
"2.	An academic repeatedly quoted in newspapers or newsmagazines may be considered to meet criterion 1. A small number of quotations, especially in local newsmedia, is not unexpected for academics and so falls short of this mark."
Amos Kloner is being quoted like mad in national newspapers in connection with his work with the Talpiot Tomb. I'll add some references as soon as I have a chance. Ecto 19:52, 1 March 2007 (UTC)
thread_title: Untitled
Talk:Literacy test

message: This article is currently exclusively about the United States, so could use a bit more global perspective.  I know other countries have had literacy test requirements for voting; we should have some information on which ones, why, and when (if) they were abolished.  Likewise for immigration; I believe many countries still require literacy in the local language as a condition of immigration, and certainly of naturalization. Or if people feel that the U.S. context is sufficiently different to require its own article, then this should be moved to literacy test (United States), and a more general article created. --Delirium 19:53, 1 March 2007 (UTC)
thread_title: Untitled

message: In the article, it indicates that the tests were applied in an unfair manner, disenfranchising literate African Americans. A description of how the application of the tests prevented literate persons from passing would be helpful.  —Preceding unsigned comment added by 216.36.186.2 (talk) 13:38, 23 October 2007 (UTC)
replies: text: In the context of the history of the United States, this is incorrect.  What were referred to as "literacy" tests were rigged for failure, and Whites were exempt from taking them.  Read the sourced content already in the article. TricksterWolf (talk) 00:46, 12 December 2013 (UTC)
thread_title:  Explanation of Application 

message: "Examples of questions asked of Blacks in Alabama included: naming all sixty-seven county judges in the state, naming the date on which Oklahoma was admitted to the Union, and declaring how many bubbles are in a bar of soap."
:This last question sounds like the sort of thing that Google would ask at a job interview. --ABehrens (talk) 22:30, 28 October 2014 (UTC)
replies: text: Google did ask this sort of question for the first six months, then stopped when it was shown that they didn't have any value at selecting good candidates.  That was 21 years ago, but the myth that Google asks these questions remains strong. (Source: I've been an interviewer at Google for 13 years.) NeilFraser (talk) 22:51, 19 July 2020 (UTC)

text: I'm deleting that comment and the one adjacent to it as the source "Caro" and "Robert Caro" have no links to anything and the statement is so outrageous and biased I'm inclined to believe it's either propaganda to serve a political agenda or out-right vandalism.(7 & 8)Jonny Quick (talk) 05:52, 1 August 2015 (UTC)
thread_title:  Bubbles in a bar of soap 
Talk:Indinavir

message: The alpha benzyl group has the incorrect stereochemistry drawn. The centre alpha to the amide is drawn as S while the structure is defined as R in the name. Not sure how to edit these structures but the dashed bond should be bolded.  — Preceding unsigned comment added by 121.44.47.4 (talk) 11:20, 20 June 2016 (UTC)
thread_title:  Stereochemistry in structure incorrect? 

message: Apart from textual and grammar errors it would be good to reorganize or even split the article in factual description and the controversies that surround a specific introduction. It would make the article easier to understand
83.97.80.89 (talk) 17:28, 27 January 2020 (UTC)
thread_title:  History / Controversy
Talk:Baldwin Wake Walker

message: It seems reasonably clear that the subject of this article was born with the surname "Walker" (his father was plain John Walker), that by the time he received a peerage, he preferred the double surname "Wake Walker", and that his descendants adopted the surname Wake-Walker (e.g. Frederic Wake-Walker) to avoid confusion as explained above. So how should he be referred to in the article? Different historians have taken different views on the matter:
* Walker
** John Francis Beeler, British naval policy in the Gladstone-Disraeli era, 1866–1880
** Alastair Wilson, Joseph F. Callo, Who's who in naval history: from 1550 to the present
* Wake-Walker
** Roger Parkinson, The late Victorian Navy: the pre-dreadnought era and the origins of the First World War
* Wake Walker
** Stanley Bonnett, The price of Admiralty: an indictment of the Royal Navy 1805–1966
Beeler quotes a letter from Disraeli to Lord Derby: “The Admiralty is governed by Sir B Walker who has neither talents, nor science—& as I believe—nor honour” showing that he was plain "Walker" as late as 1858. Gdr 16:06, 17 November 2009 (UTC)
thread_title:  Surname
Talk:Inhalational anesthetic

message: I have merged the contents of Volatile anaesthetic into this page, because the term "inhalational anaesthetic" applies to all of the volatile agents as well as agents such as nitrous oxide and xenon, which exist as gases at STP. DiverDave (talk) 00:10, 9 November 2010 (UTC)
thread_title:  merged contents from [[Volatile anaesthetic]] 

message: Anesthetic hazards doesn't seem to have enough information yet for its own article, but seems to have enough summary information to include in Inhalational anaesthetic. Closeapple (talk) 17:23, 6 April 2016 (UTC)
replies: text: Merge - Agree.  Mlpearc (open channel) 17:45, 6 April 2016 (UTC)
thread_title:  Proposed merge with [[Anesthetic hazards]]
Talk:Testosterone (patch)

message: New to this page but seems to me that Testosterone (medication) is a well developed page that could easily include this one. BakerStMD 15:33, 15 November 2016 (UTC)
replies: text: Support. Doc James (talk · contribs · email) 04:42, 16 November 2016 (UTC)
thread_title:  Merge with Testosterone (medication)
Talk:Tom Harrisson

message: This article covers his early years in great detail, his mid years in summary, and completely runs out of steam in the mid-1960s. What about his time at Cornell, and the University of Sussex in the late 60s and 70s? Does someone feel like expanding this article to balance it? Masato.harada (talk) 16:54, 23 April 2024 (UTC)
thread_title:  Where's the rest of his biography?