Talk:Ergine

message: Article LSA listed on Wikipedia:Votes for deletion Apr 27 to May 3 2004, consensus was not reached.  Discussion:
Page exists due to a persistent myth that LSA is the active hallucinogen in seeds of certain Convolvulaceae species. Actually the active agent of these seeds has not been determined, and it is probably not LSA, but one or more of the related ergolines (see that entry for discussion). Since the topic covers multiple chemicals and multiple plant species, it should live either in the chemical family entry (ergolines) or the plant family entry (Convolvulaceae). I opted for the former, made the page with general info including info on the hallucinogenic seeds, and ended up not copying over any text from the LSA entry because it is mostly not worth keeping. For example, sentence 1 is false (see ergoline). Sentence 3 talks about species of a species (???) and fails to note that Heavenly Blues etc are varieties of I. tricolor, or that many other species are known to contain ergolines. Sentence 4 is irrelavant and untrue (isolating it from all the other stuff is complicated). Sentence 5 is false. Sentence 6 is irrelevant and will potentially attract criticism of wikipedia for inciting illegal activities. That leaves sentence 2 which is neither here nor there after considering the fact that LSA is probably not of interest anyway. So I vote deleting all the text and replacing the page with a redirect to ergoline. -- Rkundalini 13:28, 27 Apr 2004 (UTC)
thread_title: Untitled

message: Meaning the constriction of veins. I read somewhere that ergine can cause this, mkaing your balls turn brown, and your lips turn blue. Anyone can confirm this?  —Preceding unsigned comment added by 86.83.121.172 (talk) 13:16, 12 November 2007 (UTC)
thread_title: VasoConstricion

message: I moved the page to ergine, since this is the name most frequently used in literature. I could be wrong but I think the term LSA was cooked up somewhere along the line in internet / amateur literature since it sounds like "LSD".  The name used by Sandoz (who named LSD) was LA-111, not LAA. The name ergine was switched to when it was first found in nature. Rkundalini 12:12, 4 May 2004 (UTC)
thread_title: Page Moved

message: I suggest you read "Practical LSD Manufacture" by Uncle Fester. Also, take a look in the Erowid Vaults under LSA. I believe that it would be impossible for it to be a myth, since crystalline LSA can be (and has been) obtained from said seeds, and used for hallucinogenic purposes. If it were really another chemical (What's your mystery chemical?), it surely would have been discovered. All of the scientific information says that LSA is a hallucinogen, refer to "Psychedelic Chemistry, Third Expanded Edition" by Peter Stafford. If you still have your doubts, I suggest you follow simple extraction methods (tried and true) to get crystalline LSA, and dose yourself.
(Above stuff apparently by "Ddhix 2002")
* Regarding your statement that ergine can and has been obtained from the seeds and used for hallucinogenic purposes, and your suggestion that I (break the law and) follow simple extraction methods to get crystalline LSA, and dose myself: both of these statements are perfect illustrations of the correlation implies causation logical fallacy pointed out by Wiwaxia above. Yes, an alkaloid extract of the seeds will be predominantly composed of ergine, yes the extract will be impressively psychedelic. This does not imply that ergine is impressively psychedelic. The fact that numerous articles, especially ones on the web (e.g. the ones in the Erowid LSA vault), say that this is true, does not make it true. Only human trials of doses of pure ergine can prove or disprove the claim, and of all the trials I know of, which are all listed in part 2 of the article Mixing the kykeon are pretty unimpressive and tend to indicate that strong somatic and soporific effects are accompanied by at best a weak psychedelic action. Unless those books provide any information on further human trials of pure ergine, they have nothing to say about the matter. If they do, could you provide us with an excerpt? The idea that ergine isn't necessarily the active agent is not some thing I have made up myself. If you need to hear it from some big names, check out chapter 17 and entry 26 of TiHKAL, and part 2 of the article Mixing the kykeon. Regarding your question of what is "my mystery chemical", it could be any of the quite a few other ergolines that have been found in the seeds in lesser amounts, or it could be a result of synergies between the various ergolines present. Or it could be, after all, that ergine really does produce impressive psychedelic effects and that the previous results were unrepresentative due to e.g. the individual response of the handful of people involved, or due to the clinical setting of the experiment (this is Peter Webster's opinion on the matter), but this is yet to be proven either way. Rkundalini 12:25, 11 May 2004 (UTC)
thread_title:  A myth? Please! 

message: While I am looking at the original article by Smith and Timmis from 1932, here's a few physical characteristics: 
: Ergine is sparingly soluble in methyl alcohol and is conveniently separated from more soluble impurities by this solvent. It crystallises in colourless prisms which decompose with frothing at about 135C; blackening with evolution of gas occurs at about 230C. The crystals contain one molecular proportion of methyl alcohol, which is retained with remarkable tenacity and is not completely removed by many hours' heating at 90C in a vacuum. Ergine is readily soluble in acetone, soluble in chloroform and ethyl acetate, sparingly soluble in methyl and ethyl alcohols, ether, benzene, and almost insoluble in light petroleum and water. It crystallises very readily from aqueuous acetone in long colourlesss plates which decompose with frothing at 115C and on further heating blacken and undergo further decomposition at about 230C. This form is a dihydrate which is stable in air but completely loses its water when kept over sulphuric acid in a vacuum desiccator.
Do what you want with it, quoting verbatim is probably a copyright violation (although, it's from year 1932 - I don't really know). Cubbi 21:53, 4 April 2007 (UTC)
thread_title: Physical properties

message: Ergine is a DEA schedule 3 drug in the United States.  What does that mean?  Widsith 10:31, 19 June 2007 (UTC)
thread_title:  legal status 

message: does it have any legal status in the UK, AUS, Canada? and is it illegal to possess the seeds containing Ergine? ~april 08  —Preceding unsigned comment added by 86.151.141.155 (talk) 14:09, 16 April 2008 (UTC)
thread_title:  legal status in other countries? 

message: I was wondering if anyone knows the effects of LSA on dogs? MattTheMan (talk) 06:22, 20 May 2008 (UTC)
thread_title:  Effect on Canines? 

message: Tell that to my freind who started feeding an imaginary horse.  —Preceding unsigned comment added by 71.139.192.181 (talk) 06:26, 12 November 2008 (UTC)
replies: text: You can get hallucinations just by wanting them. Drugs make that easier, that doesn't mean they are psychedelic  —Preceding unsigned comment added by 83.134.190.88 (talk) 14:28, 7 September 2010 (UTC)
replies: text: Morning glories are certainly psychedelic, ergine is not. C6541 (T↔C) 15:11, 15 June 2012 (UTC)
replies: text: there is ergine in morning glories, so they are 2A02:F6E:4B03:0:A339:AD1F:BF6D:2E80 (talk) 19:02, 21 March 2023 (UTC)
thread_title:  Not psychedelic?  

message: Anarchist Cookbook is no more reliable than uncyclopedia. Please remove it as source, and find semi-serious sources like erowid.  —Preceding unsigned comment added by 83.134.190.88 (talk) 14:27, 7 September 2010 (UTC)
thread_title:  Anarchist cookbook 

message: It's silly that these two routes of administration are speciffically indicated based on what has been uncovered in the literature. This implys that ergine cannot be injected intravenously, for example, as with codeine, which causes pulmonary edema. Just because you didn't find literature where it was given intravenously, doesn't mean you go and make a fancy profile that says "oral, intramuscular." classic example of Wikipedia being overly technical and overly encompassing.  — Preceding unsigned comment added by 96.232.159.249 (talk) 13:34, 26 November 2012 (UTC)
thread_title:  Routes: Oral, Intramuscular 

message: What the title says.  — Preceding unsigned comment added by PA292 (talk • contribs) 21:24, 12 February 2013 (UTC)
thread_title:  Does anyone have a copy of the Subproject 22 document? 

message: https://www.ncbi.nlm.nih.gov/pubmed/23665164
"
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
The convolvulacea Argyreia nervosa (Burm. f.) is well known as an important medical plant in the traditional Ayurvedic system of medicine and it is used in numerous diseases (e.g. nervousness, bronchitis, tuberculosis, arthritis, and diabetes). Additionally, in the Indian state of Assam and in other regions Argyreia nervosa is part of the traditional tribal medicine (e.g. the Santali people, the Lodhas, and others). In the western hemisphere, Argyreia nervosa has been brought in attention as so called "legal high". In this context, the seeds are used as source of the psychoactive ergotalkaloid lysergic acid amide (LSA), which is considered as the main active ingredient.
AIM OF THE STUDY:
As the chemical structure of LSA is very similar to that of lysergic acid diethylamide (LSD), the seeds of Argyreia nervosa (Burm. f.) are often considered as natural substitute of LSD. In the present study, LSA and LSD have been compared concerning their potential pharmacological profiles based on the receptor binding affinities since our recent human study with four volunteers on p.o. application of Argyreia nervosa seeds has led to some ambiguous effects.
MATERIAL AND METHODS:
In an initial step computer-aided in silico prediction models on receptor binding were employed to screen for serotonin, norepinephrine, dopamine, muscarine, and histamine receptor subtypes as potential targets for LSA. In addition, this screening was extended to accompany ergotalkaloids of Argyreia nervosa (Burm. f.). In a verification step, selected LSA screening results were confirmed by in vitro binding assays with some extensions to LSD.
RESULTS:
In the in silico model LSA exhibited the highest affinity with a pKi of about 8.0 at α1A, and α1B. Clear affinity with pKi>7 was predicted for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT6, 5-HT7, and D2. From these receptors the 5-HT1D subtype exhibited the highest pKi with 7.98 in the prediction model. From the other ergotalkaloids, agroclavine and festuclavine also seemed to be highly affine to the 5-HT1D-receptor with pKi>8. In general, the ergotalkaloids of Argyreia nervosa seem to prefer serotonin and dopamine receptors (pKi>7). However, with exception of ergometrine/ergometrinine only for 5-HT3A, and histamine H2 and H4 no affinities were predicted. Compared to LSD, LSA exhibited lower binding affinities in the in vitro binding assays for all tested receptor subtypes. However, with a pKi of 7.99, 7.56, and 7.21 a clear affinity for 5-HT1A, 5-HT2, and α2 could be demonstrated. For DA receptor subtypes and the α1-receptor the pKi ranged from 6.05 to 6.85.
CONCLUSION:
Since the psychedelic activity of LSA in the recent human study was weak and although LSA from Argyreia nervosa is often considered as natural exchange for LSD, LSA should not be regarded as LSD-like psychedelic drug. However, vegetative side effects and psychotropic effects may be triggered by serotonin or dopamine receptor subtypes.
"
 Iownutopia 10:33, 13 June 2017 (UTC)
thread_title:  Ergine receptor affinities! 

message: How could someone writing the "first description" of ergine preparation in 1941 describe its use back to Aztec times? Wouldn't that require drawing on older written sources? 73.71.251.64 (talk) 07:00, 3 November 2019 (UTC)
thread_title: "First description"