Talk:L-DOPA

message: In accordance with Wikipedia:WikiProject_Drugs naming policy, I propose we move this page to the INN levodopa. If you have any concern with this proposal, please discuss it on this page. Matt 18:09, 23 Dec 2004 (UTC)
replies: text: Done. -Techelf 12:33, 27 May 2006 (UTC)
thread_title: INN

message: Under the Therapeutic Use section, I'm pretty sure that this statement is wrong: 
"so it is administered with a peripheral DDC (dopamine decarboxylase) inhibitor such as carbidopa"
I believe that it should be "DOPA decarboxylase" instead of "dopamine decarboxylase"
Could you please address this minor fault.
:You're right, the enzyme involved is aromatic L-amino acid decarboxylase (a.k.a. DOPA decarboxylase). Article updated. -Techelf 12:33, 27 May 2006 (UTC)
thread_title: Dopamine decarboxylase

message: Could someone please include some information on l-dopa in foods? The fava bean, for example, contains a high level of "natural" l-dopa.
The only foods I've heard of containing L-dopa is Fava beans and Mucuna pruriens (also a type of bean in which you can buy in supplement form).  — Preceding unsigned comment added by 24.145.233.62 (talk) 14:14, 20 September 2011 (UTC)
thread_title: L-DOPA in food

message: As is the premise of the latest episode of House. Why is there no mention of this? 
It's use of reviving coma victims originated in south africa, its revival only lasts 4 hours. Very interesting, like temporary revival of the dead, just to ask some questions.
House = Fiction.
QED. Zerocannon 16:28, 16 October 2007 (UTC)
thread_title:  L dopa revives coma victims 

message: There are articles telling of homocysteine increase due to levodopa, and studies showing that folic acid could help with this. Best regards, CopperKettle 10:18, 20 March 2007 (UTC)
thread_title:  Levodopa elevates homocysteine 

message: Needs some work.  — Preceding unsigned comment added by 24.246.236.191 (talk) 03:57, 28 September 2014 (UTC)
thread_title:  Badly written introductory paragraph ;( 

message: Levodopa increases all of the catecholamines, but mostly dopamine. Since dopamine is an adrenergic, you might expect it to cause hypertension, but it is a selective-beta adrenergic receptor agonist with no significant alpha action. 
Whereas alpha receptors constrict blood vessels in intestines and stomach and stuff, beta receptors dilate vessels in skeletal muscle to allow more nutrients to go to the muscles.
The result is that since levodopa mainly increases dopamine, and dopamine works only on beta receptors, blood vessel only dilate and hypotension can occur.  —Preceding unsigned comment added by 76.216.99.188 (talk) 06:45, 14 January 2008 (UTC)
thread_title:  Levodopa and hypotension 

message: I have added some information on cellular and neuronal toxicity induced by Levodopa in the "Adverse Effects" section of the article, and have provided references to medical research journals for the statements. I believe, however, that such a section should be enlarged to include more of these related issues, as the drug is sold over the counter as a dietary supplement and safety information (especially from extracts) is scarce. 
18:03, 8 March 2008 (UTC)
thread_title:  Toxicity issues 

message: This article should be called L-DOPA.  L-DOPA is the common, scientific name for a chemical which exists as a biosynthetic precursor to dopamine and can also be synthesized in the lab.  Levadopa is the INN for synthetic L-DOPA intended for use as a pharmaceutical.  Since this article is about the substance as a chemical (structure, synthesis, etc.), the natural biological properties (synthesis, function, etc.), and its use as a pharmaceutical (role in Parkinsons, dosing, etc.) we should use the most general name, not the pharmaceutical specific one. --Selket Talk 03:34, 25 July 2008 (UTC)
replies: text: Why the uppercase? Shouldn’t this be spelled “L-dopa”? Palpalpalpal (talk) 00:29, 29 October 2012 (UTC)
thread_title:  Article Move 

message: Under side effects it states: "Disturbed respiration, which is not always harmful, and can actually benefit patients with upper airway obstruction"
This is somewhat counter-intuitive and contrary to basic emergency medicine. I would like citation, clarification, or removal. It is possible that this is simply a miscomunication and would benifit from a better explination/clarifiction 
(Croaker260 (talk) 20:22, 27 February 2012 (UTC)
thread_title:  Side Effects: Disturbed respiration 

message: "...lighter people from the drug group did better than the non-light people.[21]"
I don't have access to the reference, so what are "lighter" and "non-light" people?
Lighter body mass? Highly pigmented skin?
EdwardEditor (talk) 01:21, 27 September 2014 (UTC)
thread_title:  As a nootropic 

message: L-Dopa was the mirical drug that was the basis for the book and movie Awakenings. Herogamer (talk) 18:16, 19 March 2012 (UTC)
thread_title:  movie 

message: The following were appended to the references section, but are currently not used to support any specific article content as far as I can tell.  I'm moving them here in case anyone would like to use them to expand the article.  -- Ed (Edgar181) 13:08, 1 May 2012 (UTC)
replies: text:  Unless you are certain there is no content in the article from those sources (which would be quite a feat), they should remain in the article, even though they are not cited with inline citations. It's not ideal to cite this way, but it's still better than not citing at all. I've added them back again. —[AlanM1(talk)]— 00:51, 30 September 2013 (UTC)
replies: text: Looking closely at the article and those references, I moved one inline and removed two as unrelated to any current article content.  I also moved the external link into the article as a reference because it supported article content. -- Ed (Edgar181) 13:02, 30 September 2013 (UTC)
thread_title:  Unused references 

message: Why is the leading "L" in the name small (i.e. L-DOPA)? Should this be worked into the article? —[AlanM1(talk)]— 00:59, 30 September 2013 (UTC)
replies: text: It is a chemical nomenclature convention to use small caps font for D/L nomenclature.  IMHO, this is trivia that is out of the scope of this article.  -- Ed (Edgar181) 13:07, 30 September 2013 (UTC)
thread_title:  Small L in name? 

message: So under the side effects section, possible neurotransmitter depletion was placed there, without a citation.
I found a paper in the literature (5-HTP efficacy and contraindications), but the ideas seem sketchy to me. While competitive inhibition is certainly possible, they repeatedly cite themselves, and many of their previous papers appear to be bordering on what is colloquially called "bro-science" - unsubstantiated and often dramatic claims, or poor quality experiments/studies. Could someone else please take a look at this source and verify its credibility? (Erebusthedark (talk) 23:46, 5 March 2014 (UTC)
thread_title:  Neurotransmitter depletion 

message: is there any knowledge regarding what are the consequences of quitting (withdrawal symptomes of) the L-Dopa, or about it's effects (and if there are any, then how transient/permanent they are) on people/lab animal models without parkinson's disease (or parkinsonian symptomes inflicted by other causes)?176.63.176.112 (talk) 20:50, 28 February 2017 (UTC)
thread_title:  permanent effects/ effect in non parkinsonian people? 

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thread_title:  External links modified