Talk:Endorphins

message: (I added the properties section and mechanism of action section to replace the action section. I deleted the depersonalization section due to poor references. I added to the types section and moved the history section above types.)--Nsaunder (talk) 14:34, 7 March 2019 (UTC)

message: The text below seems to have been written by a person who speaks some other language than English as a first language:
:How endorphins/enkephalins work in human body.
:Endorphins are a type of inhibitory nerve that reduces the cell voltage of the excitory nerve, causing the signal to weaken.  It is a type of presynaptic inhibition.  How it works is that it acts as a secondary nerve that changes the calcium influx of another nerve, therefore reducing the signal.  Endorphins work to lessen the pain in humans.
:Several types of drugs that is related to endorphins that acts as an inhibitory nerve are morphine, heroin, and codeine.
Can anyone fact-check this and convert it into grammatical English?
I don't think the person is foreign, I just think they either can't write well, or don't know the proper term. Maybe they mean "never inhibitor" instead of "inhibitory nerve."?
The discussion above has been pretty much rendered moot by subsequent changes to the page. --Dcfleck 15:17, 2005 May 30 (UTC)
This and most other articles describing hormones, neuro-transmitters, etc. are written using medical jargon that is vague and confusing to the average reader. Can't these articles be written so that they use or at least explain in normal terms what is being said? If the subject was thermodynamics someone would complain that it was too technical but biology seems to get a pass on clarity. RDXelectric (talk) 00:45, 15 July 2017 (UTC)
thread_title:  Grammar 

message: There are many chemicles in the bloodstream that contribute to runners high, including adrenaline,noradrenalin dopamine, serotonin and more, so I think this is not relevant.
Therefore I'm removing, if someone's going to add something on runner's high, make a new page for it and make sure you know ALL the chemicles involved.
--92.6.232.214 (talk) 15:29, 16 May 2009 (UTC)
thread_title: Endophines are just some of the many chemicals that contribute to the runner's high 

message: :" their research possibly demonstrating the high comes from completing a challenge rather than as a result of exertion"
Is this widely considered to be a possibility, and should it be in the article? I don't know much about this, but I often experience this 'runner's high' after exercise without having any feeling of accomplishment... and when I do feel accomplishment, it isn't nearly enough to explain the feeling for me personally. So from an outsider's view, this comment in the article quickly made me wonder how many scientists "some scientists" was supposed to mean, and how widely agreed apon the various explanations are... as this article might give the impression that the view of "runner's high" = "accomplishment" is a widely agreed scientific fact. Peoplesunionpro 00:37, July 25, 2005 (UTC)
Runner's high is also the object of various other stray items in this discussion page: Mechanism demystified, Disambiguation needed, Talk:Endorphin#Evidence indicating endocannabinoid causes runners high is weak., This can't be right can it?.
It's not a good idea that "Runner's high" redirects to "Endorphin", since 1° that makes up too great a part of the article, 2° the role of endorphins in that phenomenon is still controversial (are they the main factor or not?). Ideally, "Runner's high" should be a separate article, and the discussion items named above should be moved to the discussion page of that article.
By the way, in its current state the section on Runner's high is more a bit of a patchwork of different scientific opinions that are not clearly differenciated or organized (not to speak of synthetized, which might be premature).
--Zxly (talk) 14:35, 13 February 2010 (UTC)
thread_title:  So-called "runner's high" 

message: "Research has also shown that video game playing can release endorphins." This assertion needs a reference to back it up. Karl Stas 22:22, 14 November 2005 (UTC)
thread_title: Video games

message: Are you not interested in making the strong dependency between (hamster) sexual behaviour and hypophyseal ß-endorphin incretions into the brain vessels obvious? vk
I'd like to remind you to sign your posts and please don't write in all-caps.
Thank you for your understanding.
Regards,
DarkestMoonlight (talk) 13:45, 2 April 2008 (UTC)
thread_title: COPULATION ELEVATES PLASMA ß-ENDORPHIN IN THE MALE HAMSTER

message: Karl Stas took out a bunch of the unreferenced sex claims over a month ago, and no one has produced a citation, so I'm taking out the one remaining quantitative sentence, and leaving only the general statement that some claim sex involves endorphins.  It's equally unreferenced, but it's gotta be true.  --Allen 04:56, 21 February 2006 (UTC)
thread_title:  removing more sex claims 

message: The [Endorphin#Activity|Activity section] is still listed as needing references, but it certainly seems like there are plenty there (although I'd say the citations need to be cleaned up).  Is there any reason this is still there?  Can anyone offer any specifics as to why it was first added?  Andrewski 17:37, 13 June 2006 (UTC)
thread_title:  References still needed? 

message: What in chocolate causes endorphines to be released?
 Theobromine is an alkaloid belonging to the methylxanthines.
 The structure of theobromine is similar to that of caffeine.
Chocolate also contains Phenethylamine - a precursor to many
neurotransmitters - this is also thought to increase the release
of acetylcholine, another powerful brain chemical which is r
responsible for improving mood.
Theobromine in chocolate is thought to be a mimic molecule
which lowers the trigger threshold of the pineal gland and
can cause a cascade effect. Initially the mimic action will
cause increased arousal in the pleasure centers, and reaction
begins. It is short lived however. 
104.32.252.213 (talk) 21:03, 28 April 2015 (UTC)
thread_title:  Chocolate 

message: I added  tags at the bottom, as the reference only named three of the examples mentioned. As far as I know, there are alternative ways of getting "well-being" than just the endorphine-based way (dopamine and adrenaline rushes are two examples), so in my opinion every positive stimuli cannot be listed without citation as now. Narssarssuaq 19:31, 27 November 2006 (UTC)
thread_title:  Added citation needed 

message: This is an actual question, and it isn't a druggy one, either (judging from "answers" to similar questions on a question asking website, a lot of people will think that upon reading the above question). Chiss Boy 23:31, 20 February 2007 (UTC)
replies: text: Poppy seeds don't trigger an endorphin release.  They contain small amounts of morphine. —The preceding unsigned comment was added by 69.113.123.1 (talk) 13:11, 8 March 2007 (UTC)
thread_title: How Much Capsaicin, Cocoa, and Poppyseeds does it take to trigger endorphin release?

message: can you get addicted to exercise?The Right Honourable 06:49, 18 March 2007 (UTC)
thread_title:  can you get addicted to exercise 

message: I'm not entirely sure if the edit I reverted was vandalism or not, but punctuation had been removed, the article's structure had been removed...the article appeared to be reformatted into simplified class notes (in particular, before "runner's high"), for lack of better words.
[[User:Shatteredshards|Shatteredshards] ]] 05:16, 30 March 2007 (UTC)
thread_title: Reverted edit

message: could synthetic endorphins be used as drugs?
:I am no expert at all but I think that some drugs are analouges of endorphins. Since these work and are easier to manufacture (and in some cases maybe more potent) than actual synthetic endorphins there is probably little point in producing true synthetic endorphins. That's a layman's 2 cents anyway.
I'm an expert. many many endorphin analogues have been synthesized, and a few tested as drugs. firstly, they don't cross the blood-brain barrier, and secondly, they are rapidly broken down by various proteases. they are not, in fact as good as the other opiods like morphine et al. years ago R guillimen tested some during childbirth in Japan: it actually worked, but they had to be injected with the epidural, and were no better than conventional drugs. Nice idear though  —Preceding unsigned comment added by Saleemsan (talk • contribs) 22:49, 31 January 2008 (UTC)
thread_title:  could synthetic endorphins be used as drugs? 

message: In the introduction it says: "Using drugs may increase the effects of the endorphins". Which drugs? I'm assuming street drugs, but which kind? Opioids?  If you have the info, maybe you should get a source to back it up. It's my first attempted edit so, whatever. --Hecajoda (talk) 09:28, 21 November 2007 (UTC)
thread_title:  Very vague phrase 

message: After reading the article referred to in the New York Times article, (Sparling, P.(2003) "Exercise activates the endocannabinoid system".NeuroReport.14:2209-2211.) I decided to make corrections. The New York Times sometimes can stretch facts or in this case fabricate them.  —Preceding unsigned comment added by 141.195.242.74 (talk) 17:15, 28 November 2007 (UTC)
replies: text: For a better overview of the supporting evidence, look at Dietrich A, McDaniel WF. "Endocannabinoids and exercise." Br J Sports Med. 2004 Oct;38(5):536-41. . I'll try to work it into the article tomorrow. St3vo (talk) 04:53, 29 November 2007 (UTC)
thread_title:  Evidence indicating endocannabinoid causes runners high is weak. 

message: "brought on by pain, danger, or other forms of stress", I could be wrong but it was my understanding that adrenaline could be triggered by fear or danger, but endorphins were released in response to physical catalysts? Max Rebo Band (talk) 08:09, 20 December 2008 (UTC)
thread_title: Danger?

message: here you are
Goldstein A., 1976, Opioid peptides endorphins in pituitary and brain, science 193 (4258): 1081-1086.  —Preceding unsigned comment added by 145.53.96.175 (talk) 14:27, 2 January 2009 (UTC)
thread_title:  "morphine produced naturally in the body".[citation needed]  

message: "and they resemble the opiates in their abilities to produce analgesia and a sense of well-being." 
has this been prooved yet? all the article over, it is said that endorphine causes a feeling of happiness but this has not been prooved yet!!! it is only said by most of the people...
145.53.96.175 (talk) 14:30, 2 January 2009 (UTC)
thread_title:  proove 

message: "They are produced by the pituitary gland and the hypothalamus in vertebrates during strenuous exercise,[1] excitement, and climax,  "
climax, i don't think so..:
Avram Goldstein, MD; Ralph W. Hansteen, PhD 
Arch Gen Psychiatry. 1977;34(10):1179-1180. 
and & 
Author(s): Kruger T, Exton MS, Pawlak C, von zur Muhlen A, Hartmann U, Schedlowski M
Source: PSYCHONEUROENDOCRINOLOGY    Volume: 23    Issue: 4    Pages: 401-411    Published: MAY 1998  
what kind of wikipedia site is this, all untrue facts?
145.53.96.175 (talk) 15:04, 2 January 2009 (UTC)
thread_title:  false?  

message: In the section on runner's high there is this phrase: "Anandamide is similar to the active endocannabinoid anandamide."
As a non-expert on this subject this seems to be non-sense, comparing one chemical to itself.--Derek Andrews (talk) 15:14, 30 September 2009 (UTC)
thread_title:  This can't be right can it? 

message: I thought 'high' is defined as being a state of intoxication from consuming mind-alterating substances, 
therefore the sense of joy people get from having sex, eating and other instinctive activities, like exercise, is not defined as 'high'.  — Preceding unsigned comment added by 2.220.208.123 (talk) 11:47, 28 July 2012 (UTC)
thread_title:  definition of 'high'? 

message: Given that this phenomenon is only putatively caused by endorphins and has potential refutations in medical literature, this section really should not be on this page or redirect to this page from Runners High.  Nearly the entire section lacks wp:medrs-quality sources as well.  It really needs attention if anyone is willing to take the time to do a rewrite.Seppi333 (talk) 20:24, 20 August 2013 (UTC)
thread_title:  Runners high 

message: I think this was the first paper that identified the link between acupuncture and endorphin / enkephalin release in humans:
http://www.ncbi.nlm.nih.gov/pubmed/89447  — Preceding unsigned comment added by Drmike001 (talk • contribs) 18:55, 12 January 2014 (UTC)
thread_title:  Acupuncture research history 

message: Source 2 is offline. We might need a new source for this information.  — Preceding unsigned comment added by 195.35.221.218 (talk) 07:55, 19 February 2014 (UTC)
thread_title:  Source 2 

message: Aside from being untrue, having no source, and screwing up the formatting of the text, I can't find this sentence when editing the page, even though it appears in plain text.  — Preceding unsigned comment added by 96.229.38.233 (talk) 20:24, 8 March 2014 (UTC)
thread_title:  "Endorphins make you depressed" 

message: The merge discussion in a prior revision was held at Wikipedia talk:WikiProject Pharmacology#endorphin and beta-endorphin.  I deleted a fair amount of content that failed WP:MEDRS and moved other pieces of this article to beta-endorphin.  This article is about the endorphin class (α-endorphin, β-endorphin, γ-endorphin, α-neo-endorphin, and β-neo-endorphin), so content added here should be relevant to all of them.  Moreover, references in medical articles must satisfy WP:MEDRS; this policy is much stricter than WP:RS, so please familiarize yourself with this policy before adding new material to the article.  Thanks, Seppi333 (Insert 2¢ | Maintained) 00:55, 15 July 2014 (UTC)
thread_title:  Partial deletions and merge to [[beta-endorphin]] completed.  

message: 'Just like morphine itself,  "endorphins has a similar effect, by exercising or laughter.  — Preceding unsigned comment added by 50.64.39.16 (talk) 20:02, 19 August 2016 (UTC)
thread_title:  Addiction effect 

message: This article makes NO mention of the fact that morphine itself IS an endogenous chemical. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC521124/
Please someone correct this? I can, but I don't wanna mess it up.  — Preceding unsigned comment added by 75.128.157.49 (talk) 15:08, 10 July 2017 (UTC)
replies: text: It says that in Endorphins#cite note-2. Seppi333 (Insert 2¢) 15:20, 10 July 2017 (UTC)

text: I have checked that review, but as far as I can see, there is no conclusive evidence that morphine is indeed endogenously produced in the brain. This is a review in an obscure journal that cites 30 year old publications that, at least partially, used inadequate methods (e.g. antibody staining that always shows non-selective cross-reactivity). Unless they provide data from modern methods (e.g. MALDI-TOF, MS/MS) and exclude environmental contamination (e.g. plant metabolites in bovine serum for cell culture), this hypothesis is dead. I will remove it from the article. Cacycle (talk) 14:10, 22 December 2017 (UTC)
replies: text:   I was originally fine with your removal of this note when I first saw the edit; however, while working on the opioid peptide article today, I came across a concrete statement made by IUPHAR about this: " [117]". Since they're the most authoritative source for pharmacology information that I know of, I've restored the note and added this reference. Seppi333 (Insert 2¢) 21:24, 28 December 2017 (UTC)

text:  FWIW, the study they cited used GC–MS/MS. Seppi333 (Insert 2¢) 21:45, 28 December 2017 (UTC)
thread_title:  What about morphine? 

message: Hi! I am a student Wikipedia editor and have expanded on synthesis of endorphins. I have found multiple sources confirming that peptide convertase 1/2 are responsible for cleaving POMC into [beta]-endorphin within budding vesicles from the Golgi apparatus and reflected that here. I saw in a previous Talk page post that the information needs to be relevant to all of the endorphins in this class—and I feel as though this information is relevant to [alpha]- and [gamma]-endorphins as well because they are cleaved from [beta]-endorphin. I have added this information under the first paragraph. Vrwclemson (talk) 22:57, 8 November 2020 (UTC)
thread_title:  Synthesis expansion