lflage/wiki-talks huggingface dataset:
Talk:Mercaptopurine

message: Article contains no history of the drug (date of discovery, start of use, etc.)  —Preceding unsigned comment added by 96.244.38.2 (talk) 05:44, 1 April 2008 (UTC)

message: Editing suggested
*At present the entry for Azathioprine, which is the pro-drug of Mercaptopurine, is being edited, and it would be a good idea to ensure the 2 drug entries are reasonably coherent, as they have very little difference in action. The section on adverse effects here is quite good compared to Azathioprine - it emphasises the signs that patients may see if they react to Mercaptopurine. Wikipedia is probably used by patients on drugs as as alternative source of medical advice on side effects, rightly or wrongly, so it is important to get the embedded advice right.
*The sentence; "every woman in the mercaptopurine arm of the study had fetal cardiac activity at follow-up (two weeks later) and was given a suction abortion" seems unnecessary and may be offensive to some readers, and could be deleted without affecting the information.
    - Jad 10 Sep 12  — Preceding unsigned comment added by 203.27.62.92 (talk) 23:46, 9 September 2012 (UTC)
thread_title:  Editing?
Talk:Lenalidomide

message: In relapsed or refractory myeloma, 60% complete or partial response isn't bad. JFW | T@lk 01:50, 29 November 2007 (UTC)
replies: text: Phase 3 trial study of relapsed or refractory multiple myeloma, shows progression-free survival at 12 months of 83.2% when Daratumumab is combined with lenalidomide and dexamethasone, compared to 60.1% in control group of lenalidomide and dexamethasone alone. ATharanee (talk) 22:19, 19 June 2020 (UTC)
thread_title:  Myeloma study 

message: Given that NICE is still reviewing its recommendation (http://www.nice.org.uk/guidance/index.jsp?action=byID&o=11937) I wonder why the Daily Mail would anticipate on the verdict. JFW | T@lk 01:13, 29 December 2008 (UTC)
thread_title:  Daily Mail 

message: Is there a typo in the "Mechanism of Action" paragraph? Is the 2nd use of the term "in vitro" there correct? Should it not read "in vivo"?  —Preceding unsigned comment added by 142.76.1.62 (talk) 17:03, 7 January 2010 (UTC)
thread_title:  Mechanism of Action 

message: Does anyone have sources about the fact that lenalidomide is not teratogenic? Documents published by Celgene (the manufacturer) say otherwise: "Preliminary results of an ongoing study show that lenalidomide is teratogenic in animals and is expected to be teratogenic in humans". PsychoWEU (talk) 16:01, 17 November 2012 (UTC)
thread_title:  Teratogenicity 

message: ,  and now  are repeatedly adding the same sources to the article. They are either laboratory-based primary sources or primary clinical trial studies. Despite pointing out the importance of WP:MEDRS, and my addition of content based on secondary sources, the same sources keep returning.
Guys, this is not a clinical article. It is an encyclopedia article for general use. We use different sources here - the kind of sources you would imagine encyclopedias to use. JFW | T@lk 11:43, 26 January 2014 (UTC)
replies: text: Point well made.  Section revised with only secondary sources.  — Preceding unsigned comment added by 65.175.196.35 (talk) 13:37, 26 January 2014 (UTC)
thread_title:  IPs and primary sources 

message: Did UK NICE or anyone calculate a cost per QALY for any indications ? - Rod57 (talk) 13:22, 12 June 2016 (UTC)
thread_title:  Did NICE or anyone calculate a cost per QALY 

message: US patents expiring in July 2016 : 6,281,230 ; 6,555,554 ; 7,119,106 ; 8,288,415 - Rod57 (talk) 22:22, 11 August 2016 (UTC)
thread_title:  Four lenalidomide patents expiring July 2016 

message: The stereochemistry is wrongly drawn in these structures. I don't have a program here to redraw properly. Both wedges have to be reversed so that the narrow part points towards the stereogenic carbon (IUPAC). Could someone with a good drawing program help with this?
Peonor (talk) 06:35, 17 December 2018 (UTC)
replies: text: User:Vaccinationist fixed it on January 5. Thanks for the report! DMacks (talk) 02:34, 14 March 2019 (UTC)
thread_title:  Problem with structures
Talk:Furazolidone

message: When was it discovered, and when were its approvals for clinical indications ? - Rod57 (talk) 12:39, 13 March 2013 (UTC)
thread_title:  When approved 
Talk:Desonide

message: What is desonide and what condition is treated with this product?  —Preceding unsigned comment added by 71.250.250.118 (talk) 20:46, 19 September 2008 (UTC)
Talk:Bupivacaine

message: Where in the world do they refer to local anesthesia as "freezing tissue"? I have never heard that term before (I'm in the US). Sbreheny (talk) 09:32, 14 December 2015 (UTC)
replies: text: In Canada. Have changed it to "decreased feeling". Doc James (talk · contribs · email) 13:35, 14 December 2015 (UTC)
thread_title:  Freezing 

message: I don't think that "local anesthesia" is that much of an advanced medical term. The first paragraph of the lede reads like a Simple English article. —Hexafluoride Ping me if you need help, or post on my talk 14:57, 4 February 2017 (UTC)
replies: text: Per WP:MEDMOS we use easier language in the lead, so the current wording is perfectly fine. Doc James (talk · contribs · email) 08:33, 6 February 2017 (UTC)
thread_title:  "Decrease feeling"? 

message: Bupivacaine is a common active ingredient in euthanasia cocktails used in countries that have legalized this.  Usually in combination with sedatives and analgesics. 2601:600:9080:22A0:B8FF:764E:BC09:8D61 (talk) 00:59, 19 July 2023 (UTC)
thread_title:  Euthanasia
Talk:Ceftazidime

message: The IUPAC Name should be: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}--ChemSpiderMan (talk) 03:19, 26 May 2008 (UTC)
thread_title:  IUPAC Name 
Talk:Abada (rhinoceros)

message: Oh, you fiend.  How could I ignore this? 
You really need Clarke's The Rhinoceros from Dürer to Stubbs: 1515–1799  - if I remember correctly, Chapter 2 is about this rhinoceros and its depictions.  See also  and  -- ALoan (Talk) 17:56, 18 July 2007 (UTC)
replies: text: ALoan back for a fleeting moment....Blnguyen  (bananabucket) 06:22, 23 July 2007 (UTC)

text: Ha! I'll see if I can get a copy. There are plenty more rhinos at fr:Rhinocéros célèbres en Europe which I promise to stay away from if you come back (it's either that or I put Mary Seacole up at FAC ;)) Yomanganitalk 22:38, 18 July 2007 (UTC)
Talk:Councillor

message: Hi,
In Poland there is "radny miasta" (member of city counsil), "radny gminy" (member of the council of the gmina), "radny powiatu" (... powiat) and "radny sejmiku województwa" (... województwo). Shall I make a interwiki-link between Polish radny and herewith councillor?
Rozek19 17:58, 18 July 2007 (UTC)
thread_title: [Untitled]

message: I was hoping for a reference to a legal source for the statement that the title "councillor" should only apply to city, district or borough councillors. Debrett, for all that it is a well-established style guide, is not a legal reference book and the question of whether the title is valid or not is a legal, not stylistic one. MarkSG (talk) 19:33, 26 January 2012 (UTC)
thread_title: "Councillor" as a title.

message: This page not only deals more or less singularly with the UK, it only really has an English perspective within that. Tartan Nutter (talk) 16:29, 25 January 2008 (UTC)
thread_title: Worldwide view, or lack thereof
Talk:Vigabatrin

message: 2 and 3 in the mechanism diagram have the allyl on the wrong C
17:55, 4 October 2014 (UTC)
thread_title:  Mechanism diagram 

message: My name is Julia Simonsen, and I work for H Lundbeck A/S as Medical Information Specialist. My intent is to provide referenced and accurate information to the editors of Wikipedia for their use in Lundbeck related articles in order to help ensure that Wikipedia has the correct and latest information. Please see my user page JuliaSimonsen for information regarding my intentions for engagement on Wikipedia in alignment with their conflict of interest. Thank you.
I have noticed errors Adverse Events (central nervous system & sensory)) and Drug Interactions sections on the Vigibatrin wikipedia page
Please find correct, up-to-date information for: Adverse Events (central nervous system & sensory)) and Drug Interactions, in the  
Sabril prescribing information  — Preceding unsigned comment added by JuliaSimonsen (talk • contribs) 10:50, 16 November 2015 (UTC)
thread_title:  Flag errors on Vigabatrin page. 
Talk:Isocarboxazid

message: This super-stub on marplan/isocarboxazid reflects mostly 'lore' long accepted but not supported by evidence (i.e. the unsupported assertion that other medications are 'safer'; one could easily find a citation independently asserting it, but said outside citation simply be an assertion. As it happens, the latest 200 patient study regarding tyramine reactions found none with isocarboxazid, and clinicians still familiar with it...never actually heard one mention it; it's long been known that the 'cheese reaction' is very prominently associated not with hydrazine MAOi antidepressants but with mechanistically similar (but not structurally) MAOi 'parnate'--which does contain substantial dietary risks (again, decades of experience have lead to a much-reduced list of dietary restrictions even there).
Further, and also unsubstantiated, this article mentions drug reactions, whereas (Bodkin, Cole 2006) note that in fact all tricyclic antidepressants but clomipramine appear safe in combination with isocarboxazid and its cousins, notwithstanding exactly one documented case involving a dose of parenteral trimipramine. There's also literature and a wealth of clinical evidence substantiating the proper use of stimulants in combination as well, to enhance the already superior AD effect of isocarboxazid, parnate, or phenelzine if at all adequately dosed, and as the second-line treatment to combat their primary side-effect of moderate orthostatic hypertension (after NaCL): 2.5-5mg d-amphetamine, increasing until normal diastolic BP is maintained.
In short, this stub is perhaps 35 years out of date, not reflecting the experience demonstrating the many ways clinicians familiar with the medications are well aware previous dangers were greatly exaggerated; the article is further remiss in not mentioning superior efficacy data, nor in adequately warning of isocarboxazid's rather more serious danger to the human liver. In short, heavy rewriting is needed by someone who knows the medication and is not given to throwing around loose 'conventional wisdom' which is, at the very least, undemonstrated, if not entirely false. Who wrote this article, then, and why are there so many incorrect AND unsubstantiated assertions? Why is are the actual medical concerns (hepatic) inadequately mentioned? This sort of writing can help no one, and is fundamentally disinformative and unacceptable here.2604:2000:6B15:C300:14A0:AD26:555A:AB25 (talk) 03:05, 23 September 2016 (UTC)
Talk:Caucasian origin of the Azerbaijanis

message: This line:
It should also be noted that citizens of the Republic of Azerbaijan, may have different origins than the Azaris of Iran, most likely Caucasian, with Iranian Azaris being of Indo-Iranian (i.e. 'Aryan') descent. 
is original research and you cannot find such claims in any reliable source. --Grandmaster 10:13, 23 July 2007 (UTC)
replies: text: Not OR, supported by Genetic tests. Infact, it shouldnt even say "may" because its fact.Hajji Piruz 03:21, 24 July 2007 (UTC)
replies: text:  It is your personal interpretation of tests, which is not allowed. If you can find such an interpretation made by an authoritative scholar, you can add it to the article, but you cannot make any interpretations yourself, it is OR. --Grandmaster 04:49, 24 July 2007 (UTC)
replies: text: I simply added the genetic tests. Also, I removed Parishans interpretation, as the quotes taken always point to a particular origin.Hajji Piruz 16:09, 24 July 2007 (UTC)
thread_title:  OR 

message: Hello the source never say that they are not Turkic I checked so until it can please tell me here. --Isfaner 23:58, 18 September 2007 (UTC)
thread_title:  Turkic
Talk:Vinorelbine

message: Hi everyone,
As I am currently working with vinorelbine, I couldn't help noticing that the structure you have posted in Wikipedia is not correct. Please have a look below at the sites from Sigma and NZ Medicines and Medical Devices and Safety Authority whether you agree with me:
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/V2264
http://www.medsafe.govt.nz/profs/datasheet/v/VinorelbineEbeweinj.htm
Thanks in advance,
Christoph  —Preceding unsigned comment added by Cmschultes (talk • contribs) 14:35, 16 October 2008 (UTC)
thread_title:  Vinorelbine structure
Talk:Herbert L. Pratt

message: Much of the article was copied without attribution from Passportland.com. I've cited the website, but it is not a reliable site (RS), as it gives no sources for its facts.Parkwells (talk) 17:02, 25 February 2012 (UTC)
thread_title: Copyright vio and lack of RS
Talk:Naringenin

message: There is a wealth of interesting data to be found in the Duke Phytochem DB here.
Common plants that contain this chemical include: Orange, Grapefruit, Tomato, Oregano, Parsley,  Sour Cherry, Milk Thistle fruit, Thyme
from the above mentioned Duke DB source is this list:
*Citrus sinensis (L.) OSBECK -- Orange; 35,000 - 45,800 ppm in Pericarp;
*Lippia graveolens HBK -- Oregano; 85 ppm in Root; 70 ppm in Shoot;
*Artemisia dracunculus L. -- Tarragon; 44 ppm in Shoot;
*Anacardium occidentale L. -- Cashew; in Seed;
*Camellia sinensis (L.) KUNTZE -- Tea; in Shoot;
*Centaurea calcitrapa L. -- Star-Thistle; in Plant;
*Citrus aurantium L. -- Bitter Orange, Petitgrain; in Plant;
*Citrus paradisi MacFAD. -- Grapefruit; in Fruit;
*Equisetum arvense L. -- Field Horsetail, Horsetail; in Plant;
*Glycine max (L.) MERR. -- Soybean; in Leaf;
*Glycyrrhiza glabra L. -- Commom Licorice, Licorice, Licorice-Root, Smooth Licorice; in Shoot;
*Lycopersicon esculentum MILLER -- Tomato; in Fruit;
*Monarda didyma L. -- Beebalm, Oswego Tea; in Plant HHB;
*Origanum vulgare L. -- Common Turkish Oregano, European Oregano, Oregano, Pot Marjoram, Wild Marjoram, Wild Oregano; in Plant;
*Petroselinum crispum (MILLER) NYMAN EX A. W. HILLL -- Parsley; in Plant;
*Prunus cerasus L. -- Sour Cherry; in Fruit;
*Prunus persica (L.) BATSCH -- Peach; in Plant;
*Silybum marianum (L.) GAERTN. -- Lady's Thistle, Milk Thistle; in Fruit;
*Thymus vulgaris L. -- Common Thyme, Garden Thyme, Thyme; in Plant PAS PCF;
*Vigna radiata (L.) WILCZEK -- Green Gram, Mungbean; in Plant; 
Zarkme (talk) 00:37, 1 November 2011 (UTC)
thread_title:  Duke Phytochem data 

message: This edit was justified to remove the elaborate hyperbolic conjecture about biological and clinical effects of naringenin, as projected from in vitro and early-stage lab and clinical studies. There were no WP:MEDRS reviews used (because they don't exist) for any of these supposed effects. 
As for other flavonoids, the effects of naringenin in vivo may be impossible to study under current research conditions. The main points are that a) the parent molecule is rapidly degraded during digestion into smaller metabolites, which b) have unknown fates in the body, and c) are either bound to blood proteins or excreted into urine within minutes. Zefr (talk) 23:59, 9 May 2024 (UTC)
replies: text: All around just bad sourcing, mostly animal models without any good reviews as you noted. There isn't any good clinical data on this subject currently. It's probably worth checking if any other Wikipedia articles related to flavanoids are citing unreliable content like this. I will take a look. Psychologist Guy (talk) 13:48, 10 May 2024 (UTC)
thread_title:  Removing extensive misinformation
Talk:Fosphenytoin

message: — Assignment last updated by JustinxLane (talk) 19:04, 2 June 2023 (UTC)
thread_title: Wiki Education assignment: PHMD 2040 Service - Learning Spring 2023
Talk:Sitaxentan

message: This article begins with a mention regarding the spelling of sitaxentan. In essence, it says sitaxsentan is incorrectly spelled.
According to the Monograph (from Pfizer) posted on the electronic Compendium of pharmaceuticals and Specialties (CPS, published by the Canadian Pharmacists Association), the spelling sitaxsentan is fine. https://www.e-therapeutics.ca/cps.showMonograph!searchMonographsAction.action?simplePreliminaryFilter=sitaxsentan%2c+sodium+de
 
This is what Canadians will read when prescribed this drug.
Actually, typing sitaxentan in the eCPS query field yields no result. 
Moreover, a quick search on Google yielded 20400 results fort sitaxsentan and 25600 for sitaxentan. Both terms seem accepted.
My suggestion is to remove the wording incorrectly from the assertion. 
Myrgag (talk) 19:34, 3 March 2010 (UTC)
replies: text: With active ingredients the WHO's List of Recommended International Non-proprietary Names (INN) should be regarded as the sole authority. In list No. 45 (published in WHO Drug Information, Vol. 15, No. 1, 2001, online at http://whqlibdoc.who.int/druginfo/INN_2001_list45.pdf) it specifies on p. 51 "sitaxentanum / sitaxentan" - clearly making "sitaxsentan" the misspelled version. The s probably slipped in because the other drugs of this class (bosentan, ambrisentan,...) happen to have an s at this place, and so the notion arose that these are the "-sentan" drugs (just as the AT-II antagonists are the "-sartan" class). But the API's INN is very clearly specified without an s by the WHO, and so "sitaxentan" should stand. Glst2 (talk) 18:48, 4 March 2010 (UTC)
thread_title:  spelling of sitaxentan
Talk:List of New England Fifty Finest

message: Sometimes wikipedia editing is good, sometimes not so good. Back in 2013, an anonymous editor added a 51st m0untain that didn't belong. That was removed within a month or two, but all of us failed to notice that the editor had changed the introductory sentence to say that this is a list of 51 peaks. That silly, incredibly obvious error has been there for five years! 
oops. - DavidWBrooks (talk) 17:06, 18 May 2018 (UTC)
replies: text: I wonder if it stayed up there because there are two mountains entered at number 26. Now, since we're talking prominence, only one of them would have the right amount, but we don't know which one. --Ken Gallager (talk) 19:17, 18 May 2018 (UTC)
replies: text: Interesting - of course since No. 26 is an "or" not an "and" there are still only 50 peaks, we just don't know one of them exactly. - DavidWBrooks (talk) 20:45, 18 May 2018 (UTC)
thread_title: A 5-year- error 

message: An editor has pointed out an obvious question: Who draws up this list? Goig online I find it cited many times but no source as to who measured the prominences. - DavidWBrooks (talk) 13:42, 26 March 2023 (UTC)
thread_title:  Who maintains this list?
Talk:Methacholine

message: Quote from the article:
"It is broken down at a relatively slow rate within the body, due to its resistance to acetylcholinesterases.
Methacholine has a β-methyl group which provides selectivity towards M-type receptors as compared to N-type receptors. The quarternary ammonium group is essential for activity. The ester however makes it susceptible to the enzyme acetylcholine esterase.[2]"
These statements are seemingly contradictory. Is it susceptible to AchE? If so, to what degree? Dryphi (talk) 03:35, 2 June 2011 (UTC)
thread_title: Susceptibility to Acetylcholinesterase

message: Reference 2 doesn't link to anything, or exist. 129.78.56.166 (talk) 11:32, 31 August 2018 (UTC)
replies: text: I fixed the link.  Thanks for catching the problem and reporting it here.  -- Ed (Edgar181) 12:15, 31 August 2018 (UTC)
thread_title: Dead link
Talk:Etoposide

message: There is a recent article about a U.S. Navy aircraft squadron called VP-16, which at this moment is named VP-16 (U.S. Navy). It is one of about 20 articles on squadrons named "VP-nn", and the only one that isn't named just "VP-nn". I would love to be able to rename the Navy article as plain "VP-16", and include in it a disambiguation link to Etoposide. Right now, VP-16 is a disambiguation link to Etoposide, which has a disambiguation link to VP-16 (U.S. Navy). I think that doing it the other way would be what's best for all concerned, but I don't know if Etoposide people would agree. Lou Sander (talk) 03:36, 7 March 2014 (UTC)
thread_title:  Need your input on "VP-16"
Talk:Valganciclovir

message: 1. Mechanism of Action 
2. Toxicity
3. Drug Interaction 
4. Clinical Use  
We will use PubMed to update this section.
(Glori Wai, Brandon Salce, Sarita Wanichpan, Stephanie Roman)
PEER REVIEW FROM GROUP 30:
STUDENT 1 – Does the draft submission reflect a neutral point of view? If not, specify…
: I believe most of the statements themselves are written neutrally, but question the neutrality of the Research section in that it is quoting only one trial's results about a controversial syndrome in itself (chronic fatigue). Although not the focus of my class assignment question, I will also point out the pharmacokinetics are all already available in the right-hand side's chembox so I'm not sure if it should be an article section. Stevenwsamuels (talk) 08:11, 15 November 2016 (UTC)
replies: text: The titles are clear and recognizable to the reader. However, there are some inconsistencies in terms of the first letter being capitalized in the title (see “Use in Pediatric Patients” vs. “Side effects”). Some of the titles have the first letter capitalized for all the words in the title whereas some titles do not. In the research section there is an innapropirate semicolon in the last paragraph.  Overall, I would say that this article is consistent with Wikipedia’s manual of style for medicine-related articles and presents an article that is user friendly, and easy to read for non-health professionals. 128.218.43.142 (talk) 20:02, 15 November 2016 (UTC)

text: The majority of the article looks free from plagiarism or copyright violation. One area I would be sure to include citations for is the pharmacokinetics section. One more edit I think would be beneficial is to change the wording (in the last paragraph of the Research section from "In a free preview of ....."  to something with the title of the article in it "Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease" Iaminwillmart (talk) 18:09, 15 November 2016 (UTC)
thread_title:  Group 29 Edit Plan