Talk:Sesame oil

message: Genereally, sesame oil is not used for frying as per indian cooking method. In southern India, coconut oil is widely used not sesame oil. 
Out of the 4 south indan states of kerala, tamil nadu, andhra and karnataka, coconut oil is used for cooking only in kerala. In fact in kerala coconut oil is used for cooking and sesame is applied on hair but in tamil nadu it is exactly other way around - sesame for cooking and coconut for hair.J mareeswaran (talk) 19:49, 5 July 2008 (UTC)
thread_title:  Uses / Cooking 

message: Hello. I can see that the Nutritional Values numbers in the info-box is taken from the USDA database for "04058, Oil, sesame, salad or cooking". However, this source does not explain what kind of sesame oil was tested,which is crucial information. Was it a refined, semi-refined or a cold-pressed oil? 
As some of the text in the article suggests, sesame oils may even vary from region to region and contain different amounts of nutrients. How different is "Indian sesame oil" to "ordinary sesame oil" for example? This article needs much better sourcing and explanation. 
RhinoMind (talk) 00:47, 18 August 2015 (UTC)
replies: text: There is only one source of sesame oil identified in the USDA National Nutrient Database (salad or cooking oil) which I just added to the nutrient profile table. I am not aware of other reputable nutrient analyses that would provide reliable data for different preparations of sesame oil, requiring a source that is WP:RS. In my opinion, it would not matter much on actual nutrient values whether the oil is cold-pressed vs. refined or whatever, but rather taste and perhaps clarity of the sesame oil may be affected. --Zefr (talk) 01:19, 18 August 2015 (UTC)
thread_title:  Nutritional value 

message: Thank you for pointing out that the studies were in vitro. However, there were at least one in vivo study. The inhibitory effect of sesame on CYP4F2 has been confirmed by a randomized, controlled crossover trial, where 33 overweight men and women consumed 25 grams per day of sesame for 5 weeks, resulting in a 28% decrease in plasma and a 32% decrease in urinary 20-HETE, while urinary sodium, potassium, and blood pressure were not affected. (PMID 19786646). CYP4F2 is a very important enzyme, is the only known enzyme to ω-hydroxylate Vitamin E (tocotrienols as well as tocopherols), thus making it a critical modulator of circulating plasma Vitamin E levels. It is also the main enzyme involved in production of 20-HETE. CYP4F2 affects the bioavailability of Vitamin K that, in turn, affects the dosing of Vitamin K antagonists such as warfarin, coumarin or acenocoumarol. Inappropriate doses of these drugs may lead to bleeding. The CYP4F2 enzyme also regulates bioactivation of various drugs, e.g. the anti-malarial drug pafuramidine and the anti-parasitic drug furamidine. That's why it is important to know that sesame seeds, especially when consumed daily in quantities about 25 grams or more, produce serious consequences on CYP4F2 and its metabolates. This can be aggravated in individuals carrying loss-of-function alleles in the CYP4F2 gene. Do you think that PMID 19786646 is a good quality source, suitable for Wikipedia? It's full-text is freely available at https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.139352 
Here is the initial quote: "Research has shown that sesamin, a lignan found in sesame oil, inhibits the following cytochrome P450 enzymes in humans: CYP2C9, CYP2D6, CYP3A4, CYP4F2 and CYP4A11."
-- Maxim Masiutin (talk) 19:52, 18 July 2020 (UTC)
replies: text: This interpretation is all speculation from primary research, which is unreliable for encyclopedia medical content, shown as the lowest quality of evidence at WP:MEDASSESS (systematic reviews are needed; none exist for sesame oil). All but one of the sources are out of date, WP:MEDDATE, with no quality reviews published in recent years. Two sources are from unreliable journals - Pharmaceutics is not Medline-indexed (unreliable publishing history); Evidence-Based Complementary and Alternative Medicine is a quackery journal. The study in Hypertension is primary research, and 11 years old. None of this is useable for an encyclopedia. Zefr (talk) 22:10, 17 July 2020 (UTC)
thread_title:  P450 CYP inhibition 

message: requested a citation for the vitamin K content in sesame oil. This value derives from the USDA FoodData Central entry presented and sourced in the article's nutrition table. Zefr (talk) 16:28, 10 September 2023 (UTC)
thread_title:  Vitamin K content