lflage/wiki-talks huggingface dataset:
Talk:CRISPR

message: This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage.) Prior content in this article duplicated one or more previously published sources. The material was copied from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651764/. Copied or closely paraphrased material has been rewritten or removed and must not be restored, unless it is duly released under a compatible license. (For more information, please see "using copyrighted works from others" if you are not the copyright holder of this material, or "donating copyrighted materials" if you are.)
For legal reasons, we cannot accept copyrighted text or images borrowed from other web sites or published material; such additions will be deleted. Contributors may use copyrighted publications as a source of information, and, if allowed under fair use, may copy sentences and phrases, provided they are included in quotation marks and referenced properly. The material may also be rewritten, provided it does not infringe on the copyright of the original or plagiarize from that source. Therefore, such paraphrased portions must provide their source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously, and persistent violators will be blocked from editing. While we appreciate contributions, we must require all contributors to understand and comply with these policies. Thank you.  GreenLipstickLesbian (talk) 08:33, 17 May 2024 (UTC)
thread_title:  Copyright problem removed 

message: the results are promising so far
https://icecream.rocks/shared/CASPR/ 77.23.224.122 (talk) 21:20, 24 May 2024 (UTC)
thread_title:  Have you heard of CASPR ?
Talk:Reprimo

message: I am going to be working on expanding this article to include a better description of the gene and its ordinary mechanism. I will also attempt to provide an improved overview of the supposed relationship this gene has to cancer, which is in the article, as I have found it, very vague. This will be done as a part of my work in AD Gen 3595A at UWO. 
Please feel free to suggest any sources to me or to tell me what I have gotten wrong.
Adgen Agent (talk) 16:30, 16 October 2015 (UTC)
thread_title: Untitled
Talk:Retroposon

message: This page is far too technical, and is basically incomprehensible to a lay-person. It needs to be completely rewritten to be at a standard encyclopedia level of understanding. 132.203.24.74 (talk) 13:59, 15 April 2016 (UTC)
thread_title:  Rewrite needed? 

message: "NonLTR retrotransposons (such as the human L1 elements) are sometimes falsely referred to as retroposons." 
Genes IX (Benjamin Lewis 2008, Jones and Bartlett publishers)  classifies those,  eg. L1, to be retroposons and being group named Lines long interspersed repeated sequences. (22.9 Retroposons fall into three classes, p. 562) — linnea (talk) 11:21, 28 November 2014 (UTC)
thread_title:  LiINES
Talk:Zinc transporter 8

message: Qiong Huang, Jie Du, Chengfeng Merriman, Zhicheng Gong, "Genetic, Functional, and Immunological Study of ZnT8 in Diabetes", International Journal of Endocrinology, vol. 2019, Article ID 1524905, 11 pages, 2019. https://doi.org/10.1155/2019/1524905 TheShouldersofGiants (talk) 19:00, 7 January 2023 (UTC)
thread_title:  Add the connection of ZnT8 to diabetes type 1
Talk:SNP array

message: "As SNPs are highly conserved throughout evolution and within a population..."- an incorrect sentence. SNPs are not highly conserved, most SNPs fall outside coding sequences and outside regulatory regions, most SNPs are in nonfunctional DNA and evolving neutrally, only a small minority of SNPs are under selection. Also it makes little sense to say "SNPs are highly conserved throughout evolution" because SNPs are by definition intra-species variation (that's what a polymorphism is). If a SNP was "highly conserved" then it would be the same nucleotide in every individual of a species and across multiple species, but then it would no longer be classified as a SNP as it would be fixed in the population/species. The 2nd half of the sentence, "the map of SNPs serves as an excellent genotypic marker for research", has no clear meaning. I suggest the whole sentence is removed.
-End of rant-  — Preceding unsigned comment added by 131.111.176.16 (talk) 10:51, 4 February 2015 (UTC)
thread_title: Sentence issue

message: I think that probe and target are mixed up in the explanation (Section: Principles).
Aren't the probes (SNP detection oligos) fixed to the array, and the and the target sequences (i.e. the fragmented and labled genome) are washed over?
This would be supported by the picture of the DNA_microarray article.
134.99.165.175 (talk) 10:17, 4 November 2011 (UTC)
thread_title: Probes <-> Targets

message: Do you say "S-N-P" or "snip"?  — Preceding unsigned comment added by 92.213.30.142 (talk) 19:40, 20 May 2014 (UTC)
thread_title: Pronunciation question
Talk:Urban search and rescue

message: The UN established standards for USAR via INSARAG. FEMA chose to establish it's own (almost identical) standards. This article should reflect the international flavour of Urban SAR and the many countries that do it, and adhere to the UN standards for their international relief efforts.  References to FEMA documents are just one example of standards implementation. —The preceding unsigned comment was added by Tsylos (talk • contribs) 06:34, 23 April 2007 (UTC)
replies: text: I've added some UK/England refs to this and expanded. Escaper27 13:16, 19 July 2007 (UTC)

text: INSARAG marking has been updated in 2015, wiki here still showing old marking from 2006. 111.82.60.199 (talk) 02:05, 28 December 2021 (UTC)
thread_title: WRite this article from an international perspective

message: This article defines USAR differently from the INSARAG standards, which provide for three levels of capability. E.g. Light, Medium and Heavy. --TimClicks (talk) 11:10, 7 August 2008 (UTC)
thread_title:  No light USAR 

message: Three phases? Really?
Perhaps specific locations or services use three phases, but Australia and New Zealand both use an internationally-recognised six-phase USAR model (Emergency Management Australia Manual 35, section 1.14 (page 6 & 7) - http://www.ema.gov.au/www/emaweb/rwpattach.nsf/VAP/(3273BD3F76A7A5DEDAE36942A54D7D90)~Manual35-GeneralandDisasterRescue.pdf/$file/Manual35-GeneralandDisasterRescue.pdf (3.71MB)).
If the original author's area uses three phases, and they have some writing to support that, they should alter the article to reflect the specific area and include the references.
58.108.96.101 (talk) 06:47, 24 May 2009 (UTC)
thread_title:  The three phases of a USAR operation 
Talk:SOS response

message: This article is excellent and much better written than LexA and RecA.  Should the text from those pages be removed and the reader directed to this article instead?--Cank 22:06, 25 May 2007 (UTC)
thread_title:  Merge some text with other pages? 

message: The text on this page completely overlooks the contributions of Evelyn M. Witkin. --Peta 04:10, 28 August 2007 (UTC)
thread_title: Witkin

message: I assume this process only takes place in bacteria since this article is part of the Microbiology project, but it doesn't explicitly say so.Koifishkid (talk) 19:49, 6 March 2012 (UTC)
thread_title:  Only in prokaryotes? 

message: Someone wrote a section on genotoxicity testing.  It seems to be written by someone who is writing to advertise commercial products in violation of wiki policy per WP:NOTADVERTISING.  Can someone who knows more about this field decide if this entry is appropriate for this page, and rewrite this section so that it is a more general description of genotoxcitiy testing, or delete it if it is not important enough.  I deleted the outright advertising blurp, but don't know if what's left is OK. Hzh (talk) 19:21, 5 April 2012 (UTC)
thread_title:  Commercial?
Talk:RAD51

message: Rather than constructing a separate page for RadA, I think that for now I will add a RadA section and a Rad51 evolution section to this article since RadA and Rad51 are very closely related, and traditionally speaking RadA proteins have frequently been referred to as a Rad51 protein.
Fishgibblets (talk) 17:50, 7 July 2017 (UTC)
thread_title:  RadA 

message: This paper contains several highly relevant details about the mechanism and dynamics of Rad51, and I included only some basic observations. Feel free to expand on it. Jimhsu77479 (talk) 19:55, 14 March 2009 (UTC)
thread_title:  Direct imaging of human Rad51 ... PNAS paper
Talk:Bella Morte

message: Please merge any relevant content from 
* [ Songs for the Dead] 
* [ As the Reasons Die]
* [ The Quiet (Album)] 
* [ Where Shadows Lie] 
per Wikipedia:Articles for deletion/Songs for the Dead.   (If there is nothing to merge, just leave it as a redirect.)  Thanks. —Quarl (talk) 2007-02-17 21:56Z
While I am not worthy to edit the mighty wiki page, lest the wrath of the Gatekeepers Of The Truth (GOTT) should smite me, I would most humble, with a slice of cherry pie, pray adding, under categories, at the bottom, Gothic Bands.  I base this most humble assertion on the fact that they are listed as a Gothic band in the introduction http://en.wikipedia.org/wiki/Bella_Morte. GOTT, please hear my prayer, and grant me the warm feeling that I matter in this cruel universe.  And, before you condemn me as being overly sarcastic, ask yourselves how I could have gotten that way. Skunkarific (talk) 01:13, 15 September 2010 (UTC)
thread_title:  Merge from [[Songs for the Dead]], [[As the Reasons Die]], [[The Quiet (Album)]], [[Where Shadows Lie]] 

message: Based on a post from Andy Deane today, Tony Lechmanski recently passed and it sounds like the Bella Morte is over with the final concert being Tony's performance on 3/31/23 https://www.instagram.com/p/CuUxEeqv5DS/ Humpermonkey (talk) 22:55, 5 July 2023 (UTC)
thread_title:  Ended?
Talk:Transcription factor Sp1

message: Sorry, not too good at editing. The external reference for the molecular mass should be http://www.expasy.org/uniprot/P08047 (reference 1).  If someone can correct this for me I would be most appreciative.   —Preceding unsigned comment added by 137.205.159.133 (talk) 14:45, 7 January 2008 (UTC)
thread_title: Untitled

message: It would be nice if the main article could have a sentence or two as to who, and when, discovered this transcription factor, also due to historic reasons; I assume it was a quite early discovery. 2A02:8388:1641:8380:F57D:59AE:A2AE:B491 (talk) 04:50, 29 September 2020 (UTC)
thread_title:  History of the discovery
Talk:Superman (gene)

message: Hey, just letting everyone know that I'll be doing some big edits on this article over the next few weeks as part of a course (Genetics 3595 at UWO). If anyone has suggestions for what more to add, let me know
--Cchato (talk) 15:49, 5 October 2015 (UTC)
thread_title: Untitled
Talk:Suppressor mutation

message: I am a biology research using genetic screens to study the red light signaling pathway in Arabidopsis thaliana and I have recently created this page.  Suppressor mutations have been a large part of how we map and locate genes that participte in the process we are studying.  I was suprised to see that there was no content regarding this topic on Wikipedia.  Upon creating/contributing to this page I have kept the information and content relatively simple but there are still areas that can be further developed.  One suggestion is to have some images corresponding to frameshift mutations and how they are suppressed.  I will try to add an image in the near future but I wanted to get some talk going prior to doing so.Zebrabronco (talk) 16:43, 10 May 2012 (UTC)
thread_title: Untitled

message: Lots of genetics books mention suppressors (suppressor mutations), such as "Introduction to genetic analysis" and other similar books. The page currently gives a good overview (could be somewhat longer), but I think what is missing is a historic overview. Nothing too overly long but something like the folks who went through early genetic dissection. Evidently the T4 phage, Sydney Benzer (or Semour, I never remember the name... I might even confused it with Brenner, sorry) was very important, also Acridin Orange and work by Francis Crick and others. It would be useful if the main article could mention at the least a few of these, in particular the early history parts (later history is on-going as we can see). 2A02:8388:1641:8380:15C2:A3F1:9A28:71D9 (talk) 20:54, 9 November 2019 (UTC)
thread_title:  History 

message: The version 14:54, 5 November 2021‎ Citation bot of this article is translated into Chinese Wikipedia to expand an existing stub.--Wing (talk) 08:21, 4 April 2023 (UTC)
thread_title:  Translation into Chinese Wikipedia
Talk:Rho factor

message: Research suggests that this mechanism is poorly understood and seldom, if ever, called "Hot Pursuit Model of Rho Termination". I suggest that this is removed...  —Preceding unsigned comment added by Jakobkennedy (talk • contribs) 21:31, 15 April 2008 (UTC)
thread_title:  Hot Pursuit Model of Rho Termination 

message: I don't have the knowledge to do much with this article but it seems like it has some problems
* Information on transcription seems like it should be in the Transcription_(genetics) article (if it isn't already).
* The contents of the article seems like it been copied from a textbook.
Maybe someone can solve these issues. Microbiology was never my strong suit! →(Speak•MorgothX•Havoc) 05:49, 1 October 2008 (UTC)
thread_title:  Major Issues 

message: Rho is unlikely to ever encounter RNA:DNA hybrids...it's loaded on to recently transcribed RNA, motors up the strand until it pushes of the ribosome, at which point there's no more RNA and it falls off... N1ugl (talk) 22:41, 12 November 2011 (UTC)
thread_title:  unwinding RNA:DNA?
Talk:VPg

message: Please provide a link to where this is explained on wikipedia. Right now I don't know
what uridylation means. I came to wikipedia in the hope that this is explained (well,
I can simply search as-is again anyway, but a simple link would be more convenient IMO). 2A02:8388:1602:6D80:0:0:0:1 (talk)  — Preceding undated comment added 14:50, 29 January 2021 (UTC)
thread_title:  Uridylated
Talk:X:A ratio

message: This article has craved attention from an expert since 2008, and its needs appear to be obvious.  It needs more information added about this ratio, why it is different from the human method of sex determination via the Y chromosome and some good reliable sources are needed, as well.  Help! – Paine Ellsworth CLIMAX! 19:28, 23 August 2013 (UTC)
thread_title:  Expert expansion
Talk:Artificial transcription factor

message: Are there any clinical trials of ATFs ? or any preclinical work ? or any diseases thought to be amenable to treatment with ATFs ? Rod57 (talk) 03:09, 24 January 2009 (UTC)
thread_title:  clinical  significance 

message: Hi All,
My name is Owen Wilborn and I am undergraduate engineering student at UCLA. Over the next 3 weeks I plan on making improvements to this article. Below are four good starting references I will be using.
ATF = Artificial Transcription Factor
Reprogramming cell fate with artificial transcription factors - https://pubmed.ncbi.nlm.nih.gov/29389011/
–Secondary source reviewing different ATF types (CRISPR-Cas, TALEs, Synthetic Molecules, Zine Fingers) and their function in changing cell state.
Angelman syndrome: Current and emerging therapies in 2016 - https://pubmed.ncbi.nlm.nih.gov/27860204/
–Secondary source covering zinc finger proteins ATFs which bind to and repress UBe3a-As. Provides an example of a possible treatment using ATFs.
Modular design of artificial transcription factors - https://pubmed.ncbi.nlm.nih.gov/12470729/
–Secondary source, covers all the basics of what an ATF is, how it works, and how to design one.
CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future Research - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887379/
–Secondary source, covers CRISPR based ATFs and their application in cancer treatment
Please add to this list if you have any other good references or contact me if you have any questions about improving the article/want to work together on it.
Owenwilborn (talk) 06:00, 13 October 2021 (UTC)
thread_title:  Starting Point References 

message: Hi Owen,
I have completed my peer review of your article. Overall, very nice job! There is some room for improvement by adding more information to the applications sections and clarifying the ATF DNA-Binding Domain which I detail in my peer review, please take a look. 
Best,
Emily D. --Emilyrd77 (talk) 14:53, 27 October 2021 (UTC)
thread_title:  Emily D. Peer Review
Talk:SDHB

message: 1/19/17 DennisPietras (talk) 19:10, 19 January 2017 (UTC)
thread_title:  moved out of unassessed on the genetics project 

message: This article says "Note the SDHA gene is not a tumor suppressor gene." without specifying any source, while the article about SDHA says the contrary "SDHA is a tumour suppressor gene" and provides a source reference [10]. Which statement is correct?
130.60.6.54 (talk) 23:01, 22 February 2018 (UTC)
thread_title:  Is SDHA a tumor suppressor gene or not?
Talk:Claremont Football Club (Tasmania)

message: Club song 	'We're a bunch of jolly good chaps and each one is a star' This doesn't sound legitimate???? --TinTin (talk) 04:29, 26 September 2012 (UTC)
replies: text: Agreed, I've removed it for now. Jenks24 (talk) 10:50, 27 September 2012 (UTC)
thread_title: Club Song in InfoBox
Talk:Elastin

message: it is a protein  —Preceding unsigned comment added by 69.54.119.254 (talk) 18:05, 4 May 2008 (UTC)
thread_title: Untitled

message: This section reads like a press release.  I don't have any real problems with the content, but it needs to be addressed in a more neutral fashion.JSR (talk) 17:15, 1 September 2012 (UTC)
thread_title:  Use in biomedical engineering research 

message: The statement "and has 34 exons interrupted by almost 700 introns" doesn't make sense. The gene is composed of exons separated by introns, so a gene with 34 exons must have 33 introns.  — Preceding unsigned comment added by Drtomconway (talk • contribs) 04:28, 21 December 2018 (UTC)
thread_title:  Molecular biology
Talk:Granule cell

message: Please provide more information on what the granular cells in the various parts of the brain actually do.  Given that the granular cells of the cerebellum comprise such a large percentage of the total number of brain cells, this information seems important.  69.140.152.251 05:44, 16 September 2007 (UTC)
thread_title: Please

message: A suggestion was made to merge this article with granule cell (cerebellum).  I am opposed to that, as there are other types of granule cells that are quite important, most notably the granule cells of the dentate gyrus of the hippocampus.  Regards, Looie496 (talk) 23:21, 18 April 2010 (UTC)
thread_title:  Merger suggestion 

message: Hi, I'm planning on editing this article  — Preceding unsigned comment added by Haphip (talk • contribs) 12:13, 18 March 2012 (UTC)
replies: text: Cool!  If you could use any help or advice, please ask. Looie496 (talk) 18:25, 18 March 2012 (UTC)
thread_title:  Plans 
Talk:Ludovico Technique

message: I expanded this article with info from A Clockwork Orange. Does that count as a reference? That's the only source from which I got the information, so there's no original research or anything like that. -albrozdude 02:14, 17 February 2007 (UTC)
thread_title:  References 

message: Anyone concider actually trying this out; like any scientists or philosphers actually experiment with this? — Preceding unsigned comment added by A Minor Thr3at (talk • contribs) 13:24, 20 February 2007 (UTC)
thread_title:  For real?
Talk:Obolon' crater

message: I quickly added some references because the article was considered for deletion. But didn't have time to do put them in correct wiki format, so feel free to improve them and add more. Zamphuor 02:19, 17 February 2007 (UTC)
replies: text: GregU, thanks for tidying up my references, looks better now. --Zamphuor 11:20, 18 February 2007 (UTC)

message: Someone may want to apply crater template

--YakbutterT (talk) 23:32, 18 February 2010 (UTC)
thread_title:  Add Crater Infobox?
Talk:Kermandie Football Club

message: This article is hardly encyclopaedic. It needs a rescue, including sources. I may consider an AfD if this isn't fixed up by people who are familiar with the specific subject. AFL-Cool 12:36, 5 March 2010 (UTC)
thread_title:  Awful!
Talk:Business incubator

message: I only read the lead, and the lead might be more globalized than it appears, but the reader really can't tell without going beyond the text presented. 
We need more text like this (at least): 
NBIA, which operates in 40 countries, defines ...
Or: 
In America, a very strong tradition of incubation exists, particularly in the high-tech communities of Silicon Valley and East Coast university towns such as Boston (later joined by large urban centers such as Houston or Atlanta or wherever), ... a diverse ecosystem of incubators, technology parks, and business development hubs has evolved ... with some formal distinctions under state and national law. 
Readers should not be left guessing how much of this is sufficiently globalized, and where it falls short. — MaxEnt 21:22, 26 November 2018 (UTC)
thread_title:  Globalize flag 

message: — Assignment last updated by Phrynefisher (talk) 00:31, 2 June 2023 (UTC)
thread_title: Wiki Education assignment: CALIFORNIA DREAMING, THE GOLDEN STATE'S RHETORICAL APPEALS
Talk:Viral replication

message: This page says that viruses must first get into the cell before viral replication can occur. This is not true. Some viruses fuse with the cell membrane becoming part of the cell itself and some simply inject their genome through the cell wall without physically entering the cell. What must happen before viral replication is that the viral genome must get into the cell.
Cottonshirt (talk) 06:42, 28 September 2008 (UTC)
replies: text: The vial genome getting into the cell is the virus getting into the cell. If I put my hand in the cookie jar, I have gotten into the cookie jar. WAS 4.250 (talk) 17:00, 28 September 2008 (UTC)
thread_title: Error in description

message: I have corrected the statement formerly claiming that DNA viruses always rely on cellular polymerases, as it is completely wrong. Examples of DNA viruses encoding their own polymerase include adenoviruses and herpes viruses. DNA viruses however always rely on the availability of different cellular factors or metabolites required for replication, and generally in a replication permissive phase of the cell cycle. More generally, this article is poorly written and seems to contain other inaccuracies. —Preceding unsigned comment added by 140.77.192.140 (talk) 14:35, 24 September 2010 (UTC)
thread_title: DNA viruses and polymerases

message: In general the term viral replication is often used to describe only the act of replicating the viral genome. The textbook Fields Virology, which many in the field would consider the gold standard, uses the term to mean only the act of genome replication. For example viruses that undergo latency have a phase of latent replication when only the viral genome is replicated but no progeny virions are produced. It would be my opinion that this page should only discuss viral genome replication. This would also reduce overlap with viral life cycle. This page could also be renamed viral genome replication for clarity. And redirect from viral replication with a note not to be confused with 'viral life cycle'. Delyons13 (talk) 21:23, 8 December 2016 (UTC)
thread_title: Viral Replication only includes replication of the viral genome

message: The discussion is here: Wikipedia talk:WikiProject Viruses#Should Viral replication only include replication of the viral genome? Graham Beards (talk) 21:18, 9 December 2016 (UTC)
thread_title:  Merge with [[Viral life cycle]] 

message: — Assignment last updated by Rajr2020 (talk) 23:03, 3 March 2024 (UTC)
thread_title: Wiki Education assignment: Developmental and Molecular Biology Spring 2024