Talk:Imatinib

message: This article seems outdated to me, if someone would like to take the initiative, here are some resources:
http://pdbbeta.rcsb.org/pdb/explore.do?structureId=3K5V             
http://www.nature.com/nature/journal/v463/n7280/full/nature08675.html                
http://www.ncbi.nlm.nih.gov/pubmed/12654251?dopt=Abstract            
(129.128.157.245 (talk) 18:02, 25 April 2010 (UTC)
thread_title:  Making this article current? 

message: Sodium, my compliments on your additions. Please note that in the image, :Image:Mechanism imatinib.jpg, the name "Gleevec" is misspelled as "Gleevac". In case you're realllly bored :-)  JFW | T@lk 22:40, 24 Apr 2004 (UTC)
replies: text: This is getting very interesting! If there are more articles being published, it might merit inclusion in the imatinib article! PS I'm going to nominate this article as a Featured article. <BR>JFW | T@lk 09:01, 9 May 2004 (UTC)

text: I'll do it now :-) JFW | T@lk 18:25, 23 Dec 2004 (UTC)
replies: text: Heh, after discussing it at wikiproject_drugs, I agree that it should stay at imatinib, and I'll change the drug list to reflect this. Matt 21:23, 23 Dec 2004 (UTC)

text: Done, and I've added a redirect for imatinib mesilate as well. Techelf 03:49, 22 Mar 2005 (UTC)

text: The Novartis documentation refers to it as 'imatinib mesylate'. Is there a standard wikipedia policy on whether the INN or USAN (if either) should be followed? --moof 18:08, 1 February 2006 (UTC)
thread_title: older entries

message: TAYLOR, J. R., BROWNLOW, N., DOMIN, J. & DIBB, N. J. (2006) FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene, 25, 147-51.
:This was inserted into the article. I'm not sure whether it is necessary to mention this in the article. JFW | T@lk 14:05, 17 January 2006 (UTC)
thread_title:  Reference was inserted 

message: doi:10.1038/nm1446 - oops. JFW | T@lk 10:26, 28 July 2006 (UTC)
thread_title:  Heart failure 

message: Would anyone object to my replacing the current JPG image of c-abl kinase with a PNG version?
Both versions for comparison:
Image:Bcr abl sti.jpg|Current image
Image:Bcr abl STI 1IEP.png|PNG version
If there are no objections I'll go ahead and change it. I would boldly do so right now, but after seeing the current image has been in place for well over a year, I thought it best to ask first. Thanks, Fvasconcellos 14:35, 8 November 2006 (UTC)
replies: text: No objections after two days, I'm changing it. Again, if anyone would like to revert to the previous version, go ahead, or leave a message on my Talk page. Fvasconcellos 13:16, 10 November 2006 (UTC)
thread_title:  Image 

message: - legal analysis on patenting of drugs in India. JFW | T@lk 21:26, 13 February 2007 (UTC)
thread_title:  India 

message: Less transplants thanks to imatinib  JFW | T@lk 22:58, 2 May 2007 (UTC)
thread_title:  Impact of HSCT 

message: Actually relatively rare in imatinib use  JFW | T@lk 06:40, 7 August 2007 (UTC)
thread_title:  heart failure 

message: CML may occur in young women, and after 10 years there is a small database of women who carried to term having taken imatinib at some point in their pregnancy. A stereotypical set of congenital abnormalities has been identified:  JFW | T@lk 20:23, 22 June 2008 (UTC)
thread_title:  When they get pregnant 

message: ARG is also affected by Gleevec. ARG tyrosine kinase activity is inhibited by STI571. Keiko Okuda, Ellen Weisberg, D. Gary Gilliland, and James D. Griffin (2001). 74.210.192.17 (talk) 00:12, 8 December 2009 (UTC)
thread_title: Gleevec target

message: The figure of $92,000 per year cited without support in the article concerns me. I don't think it's accurate, but it is being widely cited around the Internet and even in print publications, usually without attribution to Wikipedia, but usually using verbatim text from this article. I have not been able to find a source for this figure that does not actually trace back to this very article - circular verification, as it were!
I am a CML patient on imatinib. I am intensely aware of the cost issue, since it is far beyond what I could afford if I were to lose insurance coverage. Although it is not easy to find cost information on imatinib, I have been able to find some sources, two of which I cite in my edit of the article done just now. I am unable to document anything close to the $92,000 figure for 400 mg/day. The high $40K's is what I generally come up with. I have therefore left the text that I found alone, but added two more paragraphs with additional sources and information.  —Preceding unsigned comment added by Rbethune (talk • contribs) 23:02, 29 December 2009 (UTC)
replies: text: I am a CML patient on Gleevec, and my insurance regularly (as of 2015) pays $8000 for a 30-day dosage.  this comes out pretty close to the $92,000 per year. Sorry I don't have a citation, but the figure is accurate.  Tim Bird (talk) 19:58, 23 October 2015 (UTC)
thread_title:  Cost of imatinib 

message: Cancer drug restores hair colour
http://news.bbc.co.uk/2/hi/health/2180244.stm
One of the side effects of this drug is that it can restore hair color in graying individuals.  I don't see mention in this article about this topic but I see it in Hair Color  —Preceding unsigned comment added by 69.137.14.133 (talk) 23:59, 5 February 2010 (UTC)
replies: text: I stopped taking imatinib, my hair started to go grey again. Oh well. --2.127.118.102 (talk) 10:24, 28 May 2013 (UTC)
thread_title:  Hair Color Restoration 

message: WP:MEDRS suggests that we should base our content as much as possible on secondary sources. This article is now full with allusions to primary research papers that have tipped some imatinib in a Petri dish with sick cells. How much of this content can we tolerate? Or should we find a paper that enumerates all uses of imatinib? It must be out there. JFW | T@lk 10:24, 26 September 2010 (UTC)
thread_title:  Primary source fest 

message: This article is formatted a bit strange to me. Seems more information should be put into explaining how Imatinib works as well as how effective it truly is against leukemia. Also I am not seeing any citations... Will try to clean this one.  — Preceding unsigned comment added by Gleevec (talk • contribs) 09:31, 15 December 2012 (UTC)
thread_title:  Cleanup / Corrections 

message: In para 2 of the History section of the article, there is a reference to a "lead compound".  Perhaps this should be changed to "initial compound", as it does not actually contain lead!
86.4.253.180 (talk) 18:12, 3 April 2013 (UTC)
replies: text: Not sure. "Lead compound" is the technical term. I've linked it to the appropriate explanation, does that help? --ἀνυπόδητος (talk) 18:49, 3 April 2013 (UTC)
thread_title:  Clarification of ''lead compound''

message: Article says that Gleevec is targeted but it also attacks the skin. The c-kit protein is in skin as well as GIST tumors.  
http://www.gistsupport.org/ask-the-professional/skin-related-side-effects-of-sunitinib.php 71.90.171.82 (talk) 20:09, 18 December 2013 (UTC)
replies: text: unclear what your point is.  the section on potential side effects, determined from clinical trials, already mentions skin problems.Jytdog (talk) 20:33, 18 December 2013 (UTC)
thread_title:  C-kit protein in skin as well as GIST  

message: The "fair use" criteria for a magazine cover are: 
* to illustrate the publication of the issue of the magazine in question
* with the publication name either visible on the image itself or written in the image description above,
The use in this article is not about the publication of the issue.  We cannot use it here. Jytdog (talk) 11:53, 5 November 2014 (UTC)
thread_title:  Time magazine cover 

message: It would seem worthwhile for the Imatinib article to mention the popularization Magic Cancer Bullet by Daniel Vasella. This book may not add any technical or historical detail to the page, but it is a notable event related to the drug.Andrew Oram, Editor, O'Reilly Media, http://praxagora.com/andyo/ 19:45, 12 December 2014 (UTC)
replies: text: username of wikipedia user = editor of book. Same person? Jytdog (talk) 22:50, 12 December 2014 (UTC)
thread_title:  Reference to Vasella's book 

message: The section on "Overdose" has nothing about overdose, and instead has a long list of minor side effects. 
WP:MEDMOS "a long list of side effects is largely useless without some idea of which are common or serious."
I propose deleting the "Overdose" section. Any objections? --Nbauman (talk) 15:28, 26 July 2015 (UTC)
replies: text: I would think that the valid argument(s) would be that the pedantic transliteration of what looks like the entire en bloc section in the Australian package insert is either UNDUE or perhaps COPYVIO. Trimmed to a short haircut. Is that adequate, or do you prefer to remove in toto? FeatherPluma (talk) 16:41, 26 July 2015 (UTC)
replies: text: I think the whole thing should go. Do you see any useful information there? I haven't heard of imatinib overdoses being a significant problem. --Nbauman (talk) 21:05, 26 July 2015 (UTC)
thread_title:  Overdose section 

message: Is it just for manufacture/packaging, or does it have some benefits when taken orally ? - Rod57 (talk) 11:12, 14 September 2015 (UTC)
replies: text: The discussion of the Indian patent seems to imply it was mainly for patentability/legal reasons, not efficacy. - Rod57 (talk) 11:10, 17 November 2017 (UTC)
thread_title:  Why was Mesylate salt used 

message: In the diagrams of Imatinib - what is removed/changed to create the imatinib ion in the salt ? - Rod57 (talk) 11:12, 14 September 2015 (UTC)
thread_title: How is the mesylate salt formed 

message: Eg does it affect the solubility or absorption in the gut ? - Rod57 (talk) 10:52, 14 September 2015 (UTC)
thread_title:  What is the importance of the beta crystalline form 

message: Teva and Apotex debut generic Gleevec drugs in the USA.Uziel302 (talk) 12:11, 7 August 2016 (UTC)
thread_title: New generic version

message: The Cost section has "A 2012 economic analysis funded by Bristol-Myers Squibb..." gives figures including 'related drugs' - We should replace them with the figures (in the ref) for just Imatinib, and perhaps clarify the methodology - how the various values were arrived at. ? - Rod57 (talk) 11:08, 17 November 2017 (UTC)
thread_title:  Cost justification 

message: The SVG image in the Synthesis section provides a mechanism but there's no source presented, the image is an original work (which is fine) by @葉智海 but no source or credibility is given. There is no user page in wikipedia or wikimedia commons for that image. Can anyone find a source for the synthesis of imatinib? QueensanditsCrazy (talk) 21:28, 3 May 2021 (UTC)
thread_title:  Synthesis image - original work - no source?