Talk:Sirolimus

message: Should the drug really be listed as its trade name, rather than the common chemical one?
btavshanjian
:I agree, all other drug articles i've seen on WP are under their chemical name, not their trade name, especially since the trade name can differ across countries. --81.205.3.113 (talk) 00:39, 15 July 2009 (UTC)
replies: text: Looking at popularity, "Rapamycin" produces 11372 records on PubMed, "Sirolimus" gives 8178. I think it also makes sense to have the title of the article be "rapamycin" since the intro paragraph gives the origin of the term "rapa". I don't know how the INN/USAN factor weighes into this arguement. --Tea with toast (talk) 01:36, 29 October 2009 (UTC)
replies: text: Per WP:MEDMOS, INNs should always be used as article titles. I am a major supporter of this guideline, which is in keeping with the original purpose of INNs—providing a completely unambiguous, internationally recognizable names with no industry or trade connotations. Fvasconcellos (t·c) 03:21, 29 October 2009 (UTC)
replies: text: If there is complete consensus on this, is the trade name used only because some company PR people are dominating the site?  — Preceding unsigned comment added by 75.61.141.90 (talk) 01:28, 20 August 2012 (UTC)
replies: text: In the section on "Autism in Mice" the cited research paper does not mention "Sirolimus" at all, only "Rapamycin" so in the interest of accuracy I changed the names to agree with the citation.  — Preceding unsigned comment added by 75.61.141.90 (talk) 01:37, 20 August 2012 (UTC)
replies: text: Maybe Fvasconcellos didn't make himself entirely clear: "Sirolimus" is not the trade name but the International Nonproprietary Name (INN). Rapamycin is an old name that is still often seen, but we should stick with our guidelines (WP:MOSMED#Drugs, medications and devices) and use the INN, "sirolimus". Also, I think it is confusing to use different names for the same substance, depending on how the respective sources call it -- therefore I'll undo your last edit, although I'm aware you had good intentions. Please tell me (preferably here) if you disagree. Cheers, ἀνυπόδητος (talk) 10:52, 20 August 2012 (UTC)
thread_title: Name? Sirolimus vs Rapamycin

message: Is retardism really the best terminology to be used here?  —Preceding unsigned comment added by 90.152.14.118 (talk) 09:16, 25 September 2008 (UTC)
thread_title:  Autism section 

message: Is the stereochemistry of the structure correct? I'm finding differences in online structures as to what the stereochemistry to the methyl group near the lactone should be. (Hashed bond in upper left) (Also posted on image talk page)-- 16:07, 31 January 2007 (UTC)
replies: text: I created the image using :Image:Sirolimus1.gif as a model, then checked it for accuracy against . If the stereochemistry is inaccurate, I apologize; I'll try to find alternate sources and re-check. Fvasconcellos 22:51, 31 January 2007 (UTC)
replies: text: Apparently it was incorrect. Fixed now, as is the IUPAC name—the one previously in the article was actually for tacrolimus. Thank you. Fvasconcellos 01:25, 1 February 2007 (UTC)
thread_title:  Structure? 

message: Inclusion of the statement of the rapamycin DES stent (known as Cypher and sometimes denoted as SES) may be misleading since the exact reason is debatable. One postulate includes what Dr. Renu Virmani at Armed Forces Reseach Laboratories calls a polymer hypersensitivity. If this is correct, then the statement should be included on a Wikipedia page on the Cypher stent and not on the rapamycin/sirolimus page. CClaude 216.140.123.24 (talk) 20:00, 2 December 2008 (UTC)
thread_title:  Sirolimus/ Late Thrombosis  

message: "A 2009 study indicated that rapamycin can prolong the life of mice. If this increase in lifespan were translated to human years, it might allow humans to live more than a hundred years". That could use a rewrite. Something like, "If these results were replicable in humans, average lifespan could be extended to over 100 years." 206.223.190.7 (talk) 22:46, 9 July 2009 (UTC)
thread_title:  More precise longevity statement 

message: A comment regarding the use of grapefruit to lower doses and costs of the drug have been frequently added or removed over the past few months. I  have deleted the comment.  
Grapefruit (and many other foods) is an inhibitor of CYP450 and will affect the metabolism of many drugs. The CYP450 wiki entry gives more detail. 
Grapefruit should not be consumed with Siromilus.
Bombauer (talk) 17:11, 5 April 2010 (UTC)
thread_title:  Cost - use of grapefruit 

message: The referenced US patent 5,665,7220 does not exist, in fact it has one too many digits to be a valid patent number.
The earliest US patent referencing rapamycin is 3,929,992 filed in 1974, although 5,675,732 claims a more efficient means of production and would only recently have expired.
199.246.40.54 (talk) 13:46, 6 August 2010 (UTC)
replies: text: Also 5,212,155 expires in Nov 2010 and 5,100,899  expires Jan 7, 2014 (both re inhibiting transplant rejection)    Rod57 (talk) 11:38, 8 October 2010 (UTC)
thread_title:  Patents 

message: Removed from cancer section as not notable (re sirolimus) since only in-vitro : 
 Rod57 (talk) 11:59, 8 October 2010 (UTC)
thread_title:  Removed report of in-vitro work 

message: Shouldn't Wyeth be changed to Pfizer? It should be considering Wyeth's drug portfolio is now owned by Pfizer!  — Preceding unsigned comment added by 82.195.117.137 (talk) 10:59, 10 February 2012 (UTC)
thread_title:  Wyeth is now Pfizer 

message: Has anyone investigated using Sirolimus for psoriasis?  — Preceding unsigned comment added by 71.9.22.214 (talk) 19:49, 2 April 2015 (UTC)
thread_title:  Anti proliferative 

message: At least one studie is using rapamycin as the drug name when reporting its use in sleep and circadian rhythm research in a PLoS Biology paper.
Athanasios Metaxakis, Luke S. Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, Linda Partridge. Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. PLoS Biology, 2014; 12 (4): e1001824 DOI: 10.1371/journal.pbio.1001824
Max-Planck-Gesellschaft. (2014, April 1). Well-rested flies: Therapeutic agent reduces age-related sleep problems in fruit flies. ScienceDaily. Retrieved July 10, 2015 from www.sciencedaily.com/releases/2014/04/140401173138.htm
PLOS. (2014, April 1). Age-related decline in sleep quality might be reversible. ScienceDaily. Retrieved July 10, 2015 from www.sciencedaily.com/releases/2014/04/140401173130.htm
Redwolfe (talk) 13:01, 10 July 2015 (UTC)
thread_title:  Serolimus (rapamycin) in Sleep regulation 

message: I check pages listed in :Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of :Sirolimus's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "pmid22168436":
From David M. Sabatini: 
From Mechanistic target of rapamycin: 
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 12:17, 4 March 2016 (UTC)
thread_title:  Orphaned references in [[:Sirolimus]] 

message: Currently the first paragraph ends with: "It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2)." I am confused, as later it is said to inhibit the signal transduction of the IL-2 receptor. I'm changing this sentence to reflect the information I found on https://compendium.ch/mpro/mnr/21159/html/de#7550 (unfortunately not an english source). If someone could verify this and add an english citation, that would of course be great! --134.21.47.157 (talk) 16:11, 12 January 2017 (UTC)
thread_title:  IL-2 production or signal inhibited?? 

message: Should there be a section about using Sirolimus to treat/manage fibroadipose vascular anomalies? 
https://www.deepdyve.com/lp/wiley/fibroadipose-vascular-anomaly-treated-with-sirolimus-successful-6nFSNoG0P4
http://www.childrenshospital.org/conditions-and-treatments/conditions/f/fibro-adipose-vascular-anomaly/diagnosis-and-treatment
Samsmachado (talk) 18:41, 19 January 2020 (UTC)
thread_title:  Siroliums for FAVA 

message: The biosynthesis section tells the same story three times in a row in different wordings. It should be condensed into a single, more comprehensive narrative. 85.196.224.45 (talk) 21:14, 17 December 2020 (UTC)
thread_title:  Biosynthesis 

message: It is amazing that the main guy who isolated the compound is never mentioned. I added his name, hoping to add an article on him later. Somebody removed it. Oh, well. Life is like that.  — Preceding unsigned comment added by Toofani tarzan (talk • contribs) 21:33, 25 May 2022 (UTC)
replies: text: Hi! I don't know why your addition was removed, but one common reason is lacking a good source for the statement. So if you know a reliable source saying that Sehgal isolated sirolimus, be welcome to add this piece of information. Please contact me if you need any help. --ἀνυπόδητος (talk) 07:04, 26 May 2022 (UTC)
thread_title:  Dr Surendra Sehgal 

message: they will do the test of another drug LOY-002 Name8864 (talk) 04:43, 1 December 2023 (UTC)
thread_title:  LOY-001 cant prolong the life of dog 

message: I removed this section because it did not discuss any relevant information, and only contained information about a newly approved non-generic product of the same substance. This section was out of place, and essentially read like a press release from the company or an interested party. Just-a-can-of-beans (talk) 17:40, 31 December 2023 (UTC)
thread_title:  Removal of "society and culture" section