Talk:Hypopituitarism

message: Ideally, we should have an actual MRI pituitary. A quick browse in the Image namespace and Commons has not yielded results. JFW | T@lk 15:27, 23 July 2008 (UTC)
thread_title:  Images 

message: Is there any way to increase the font size if a table must be used? --Steven Fruitsmaak (Reply) 08:27, 26 July 2008 (UTC)
thread_title:  Layout of Causes section 

message: Could the article used more than one primary source and instead use multiple sources? The entire article is essentially dependent on a single source. Gary King (talk) 00:46, 27 July 2008 (UTC)
replies: text: It is a fairly good secondary source in an area that is not exactly awash with sources. Will try to diversify. JFW | T@lk 06:45, 30 July 2008 (UTC)

text: I have found other sources (see below). Do you regard it as essential that I cut down on the 34 references to Schneider et al in favour of other sources? JFW | T@lk 15:02, 30 July 2008 (UTC)
replies: text:  I would imagine that there is a chance of bias if an entire article is referenced to one source. Gary King (talk) 03:42, 6 August 2008 (UTC)

text: OK. Which is why I've started offering contrasting comments from other sources if they disagree with Schneider. That's okay then. JFW | T@lk 06:29, 6 August 2008 (UTC)
replies: text:  Should be fine Gary King (talk) 06:44, 6 August 2008 (UTC)
thread_title:  Entire article is sourced to one reference? 

message: Skin problems well recognised in hypopit, yet not covered by Schneider:  might be useful. JFW | T@lk 06:51, 30 July 2008 (UTC)
replies: text: (Postgrad Med J) is another general purpose clinical review. JFW | T@lk 06:54, 30 July 2008 (UTC)

text: (Pituitary) general review on diagnosis and treatment (Lamberts wrote the 1996 Lancet review, so clearly a renowned pituitarologist). JFW | T@lk 06:54, 30 July 2008 (UTC)

text: (Curr Opin Genet Dev) more on genetic causes for hypopituitarism. JFW | T@lk 07:01, 30 July 2008 (UTC)

text: (Horm Res) emphasis on genetics. JFW | T@lk 07:01, 30 July 2008 (UTC)

text: (Eur J Endocrinol) hyponatraemia common in elderly. JFW | T@lk 07:01, 30 July 2008 (UTC)

text: (Endocr Rev) genetics of combined deficiencies. JFW | T@lk 07:01, 30 July 2008 (UTC)
thread_title:  Reviews 

message: I have again submitted this for good article status. Since the previous review, I have consulted a much wider range of sources and contrasted them with the Schneider source whenever posssible. I have reduced the number of references to that source to 30, which is about the minimum because I also use Schneider to support my choice of a couple of primary sources (the Regal study, for instance). I think that otherwise the article covers the subject pretty well, and I have added substantial content about the rare genetic causes, as well as the more common adult forms that are due to brain injury or pituitary adenomas. I have limited professional experience with the condition, so reading up about it was very educational. JFW | T@lk 20:14, 10 August 2008 (UTC)
replies: text: I've added the Van Aken & Lamberts review. That pretty much covers it. JFW | T@lk 23:01, 11 August 2008 (UTC)
replies: text: First half of my review is here. I'll finish it tomorrow. —CyclonenimT@lk? 00:13, 18 August 2008 (UTC)
thread_title:  Trying GAN again 

message: I've passed the article, a big thank you to anywho who has contributed to making these article better in any way, shape or form. —CyclonenimT@lk? 19:58, 18 August 2008 (UTC)
thread_title:  GAN 

message: "I HAVE A 3 YEAR OLD SON THAT WAS BORN WITH "HYPOPITUITARISM" HE WAS BORN WITH A BLOOD SUGAR LEVEL AT 11/ ALMOST DEATH.HE IS CORTISOL DEPENDENT AND TAKES A THYROID, ALSO A GROWTH HORMON SHOT EVERYDAY. HE WAS FULL TERM SO I WAS INDUCED WHEN I WENT INTO LABOR WITH HIM; THIS WOULD BE MY THIRD SON, AND THE LABOR WAS INTENSE, HIS HEART RATE WENT DOWN SEVERAL TIMES WITH THE POTASIUM THEY GIVE YOU TO GO INTO LABOR. I WAS A SECOND AWAY TO GOING FOR A C-SECTION. MY QUESTION IS COULD THIS BE THE REASON WHY IS HIS PITUITARY IS DEFORMED ONLY A SMALL PART OF THE PITUITARY? THE "SPECIALIST" SAY THAT IT COULD BE GENETIC.. MY SECOND CONCERN IS HE HAS A EXTREMELY BAD ECZEMA AND THE DERMOTOLOGY STILL HAVE NOT FOUND ANYTHING TO CALM HIS SKIN, I FEEL THAT THE PITUITARY HAS SOMETHING TO DO WITH HIS SKIN PROBLEMS, BUT ENDOCRINOLGY WILL NOT AGREE WITH ME. IF YOU HAVE ANY SUGGESTIONS OR COMMENTS PLEASE RESPOND--Indigo3 (talk) 03:13, 1 July 2009 (UTC)
replies: text: To my knowledge there is no direct link between hypopituitarism and eczema, and in fact if I search PubMed with those terms, no journal articles are returned. That means that nobody has ever written about it in the medical literature since 1966 or so. Eczema is very common so this may all be coincidental. But your child's condition is really rare so it may well be that the association has not been reported yet. JFW | T@lk 06:05, 1 July 2009 (UTC)
replies: text: Actually not very rare at large children's hospitals, which may get several kids a year with congenital hypopituitarism (neonatal hypoglycemia, jaundice, small genitalia, missing GH, cortisol, thyroid); the MRI usually shows an undersized, underdeveloped pituitary, which is generally understood to indicate that the pituitary failed to develop far earlier in the pregnancy than delivery. Some of the children born with this have identifiable genetic mutations, others don't. There is no statistical association with eczema, which is a common skin problem in infants, although one cannot ever "prove" a non-association for an individual person. You can assume they are related if you wish, but it doesnt change the treatment of either condition. alteripse (talk) 10:53, 1 July 2009 (UTC)

text: Try http://www.magicfoundation.org/www     Go over these questions with your pediatric endocrinologist. These are common issues and this is a well-known condition to a pediatric endocrinologist. alteripse (talk) 18:40, 2 July 2009 (UTC)
thread_title: Moved

message: Firstly my apologies. I edited this page (under Causes/Physical) without being aware of any protocols about so doing. I will leave it amended so that it be discussed, at least, before deletion. I am not a medical professional, in this instance I am a patient.
Secondly, my sources seem reliable, but I cannot provide a citation and hope that this can be done by others.
I am under long term treament for pain resulting from a torn L4 nerve root in my spine - and on Oxycontin. I was asked, at the pain clinic, whether I suffered from erectile dysfunction and, on affirming this, was informed that long term use of morphine affects the pituitary gland such as to reduce testosterone production. My own research did not produce any detailed corroboration.
Subsequently I was referred to a local endocrinologist who is currently investigating me for suspected panhypopit (I am already on testosterone replacement and await further test results) He has written to my GP and mentions that he has found some recent proceedings in which opioid depression of pituitary function was reported and discussed, but so far I am unable to find those proceedings. If I find this difficult and nobody has provided the citation, I will seek it when I next meet this consultant.
Once again, my apologies for any rules broken, but I guess my view is that the pursuit of truth is far more important than quibbling over niceties!
Ian
Intelfam (talk) 23:43, 28 July 2009 (UTC)
replies: text: The important question is whether there is a definite link reported in high-grade medical sources. If this has been very sporadically reported, it may not be appropriate to mention it here. Let us know if your consultant can show a source. I can't imagine why opiates would interfere with pituitary action. JFW | T@lk 17:01, 30 July 2009 (UTC)
thread_title:  Causes of Hypopituitarism 

message: Should there be an "In popular culture" section about, for example, the fact that the titular protagonist in Orphan has hypopituitarism, possibly with a bit about how the portrayal of the condition was inaccurate? There are probably other occurrences of the condition in popular culture, but even if there aren't, it might be worth making the section anyway. PenguinofDeath 18:02, 6 November 2009 (UTC)
replies: text: On the whole that would be WP:TRIVIA and I would only include such a piece of information if the cultural depiction has measurably changed public perception of a particular illness. JFW | T@lk 22:59, 7 November 2009 (UTC)
thread_title: Proposed new section

message: I noticed the first sentence of the article states that hypopituitarism is marked by "decreased secretion of one or more of the eight hormones normally produced by the pituitary gland."  Should this be corrected to read "normally produced or secreted?"  I believe some of the hormones (e.g. ADH) are actually produced by the hypothalamus and released by the pituitary.  —Preceding unsigned comment added by 99.224.145.231 (talk) 05:46, 20 December 2009 (UTC)
replies: text: That is technically correct. Feel free to fix it if you find the time before I do. Perhaps all the sentence should say that the hormones are secreted in the pituitary. JFW | T@lk 01:18, 21 December 2009 (UTC)
thread_title:  Hypothalamus? 

message: Can pituitary failure be cause by solvent abuse?  —Preceding unsigned comment added by 92.21.132.44 (talk) 22:30, 19 June 2010 (UTC)
replies: text: Don't know, not according to the sources I used. JFW | T@lk 22:22, 29 June 2010 (UTC)
thread_title: Question

message: I initially misread this as describing ischemia in an infant rather than in a female who has just given birth.  I am going to alter the wording to make this a little clearer if there are no objections. Bobsagat (talk) 21:52, 11 December 2010 (UTC)
replies: text: Lovely, thanks for that. JFW | T@lk 22:09, 11 December 2010 (UTC)
thread_title: Sheehan syndrome

message: Please can you tell me why you only mentioned levothyroxine as treatment for hypothyroidism when there is also Natural Desiccated Thyroid Hormones (NDT) and Liothyronine? (also these 3 drugs are used in combination therapy, some take NDT and T3, some NDT and levothyroxine and some Levothyroxine and Liothyronine by the way)
I tried to edit your article a few times and I have been HIGHLY told off by user Novangelis saying that I did not provide reputable references to my additions of NDT and liothyronine and also 'accusing me' of not agree with the 'reputable' endocrinologists organisations recommendations.
I never stated my preference and if I agree/disagree to any treatment I merely ask for an edit on this article to ACKNOWLEDGE that 3 main medications are used for treating hypothyroidism, that is all, nothing more nothing less.
I am new to this wikipedia staff so please be patient with me, I'll learn.
Respectfully
----  — Preceding unsigned comment added by Paleohack (talk • contribs) 19:27, 6 September 2012 (UTC)
replies: text: The stuff you tried to add did not comply with WP:MEDRS, among other policies, so check that one out first.  Dbrodbeck (talk) 19:43, 6 September 2012 (UTC)

text: Wait for discussion to occur here, and see what other editors think.  Be patient, we work by consensus, and we are from all over the world, so you have to factor in time differences etc.  Dbrodbeck (talk) 20:02, 6 September 2012 (UTC)

text: This had the markings of fringe advocacy, head to tail, even before these additions were proclaimed "the truth", which is ironic, given how totally wrong it is. Starting with the unusual product description emphasizing the word "natural" for a highly processed product, to the inability to find the footnotes a couple of sentences away, to the reinsertion of nonfactual material using dismal sources (the journal not listed in PubMed was the best and it went downhill from there), the nature of the post was obvious. A massive dump of "references" (241, mostly irrelevant) to my talk page was another sign. The fact that the incorrect material was repeatedly added to the article (and the "references" to my talk page) is also indicative. While out-of-date therapies can work in primary hypothyroidism, where you just have to get TSH to budge a little (but not too much), TSH is meaningless in the management of the secondary hypothyroidism from hypopituitarism. Treatment is monitored by targeting T4 to about two thirds of the way up normal range (plus clinical assessment). Administration of T3, especially in variable amounts, runs counter to the therapeutic goals. Of course, that is just the opinion of experts published in review articles in academic journals, not "truth".Novangelis (talk) 05:57, 7 September 2012 (UTC)
thread_title:  why is levothyroxine the only treatment mentioned in this article for hypothyroidism? 

message: Currently the citation for mortality is weak, and more work has recently been done in this area. doi:10.1210/jc.2014-3787 is a SR/MA of mortality and contains a couple of important pointers (e.g. sex differences). I will need to read it before adding specific associations. JFW | T@lk 10:11, 8 February 2015 (UTC)
thread_title:  Excess mortality 

message: ... is often transient, usually involves GH deficiency, and has not been studied well beyond its incidence doi:10.1210/er.2014-1065 JFW | T@lk 20:17, 10 May 2015 (UTC)
thread_title:  Post-traumatic hypopituitarism 

message: doi:10.1016/S0140-6736(16)30053-8 - perhaps an opportunity to replace older sources. JFW | T@lk 08:36, 2 September 2016 (UTC)
thread_title:  Lancet seminar 

message: doi:10.1210/jc.2016-2118 - Endocrine Society guideline on hormone replacement. JFW | T@lk 15:55, 19 October 2016 (UTC)
thread_title:  Guideline 

message: Under this section of the article on hypopituitarism, second paragraph, third sentence, the hormone is referred to as "Sonic hedgehog".  Please edit this to contain the proper hormone name.  I cannot advise what that is, as I am not an expert; I was looking for information on the condition and noticed this irregularity.  I hope it will be resolved soon, thank you.
2602:306:C548:4959:1946:C273:4ADA:1933 (talk) 00:16, 26 January 2018 (UTC)
replies: text: It's the correct name. Read the Sonic hedgehog article. This is not about the SEGA game but simply reflects the fact that some scientists actually have a sense of humour! JFW | T@lk 09:15, 26 January 2018 (UTC)
thread_title:  Pathophysiology 

message: Male Stonershash (talk) 06:23, 6 July 2022 (UTC)
thread_title:  hypopituitarism