Talk:5α-Reductase 2 deficiency

message: The book Middlesex, an amazing book, is narrated by Cal who has 5 alpha reductase deficiency and provides a very interesting look at the social ramifications of such a condition. I highly recommend the book, it is very well done. 
Edited "testes" to "testicles" for article tone consistency.
Does no one think it appropriate to include the 'Guevodoces'/Dominican Republic information? Varilux 07:31, 3 November 2005 (UTC)
thread_title: discussion of the article

message: The articles says that patients "often" suffer from primary amenorrhea. Since they do not have any female internal organs, wouldn't patients ALWAYS suffer from primary amenorrhea? Graymornings 03:13, 7 October 2007 (UTC)
replies: text: I think the text needs some extending on this. More and more 5ARD patients are currently raised as males (better surgical outcome than 30 years ago, possibly better gender outcome?). Considering amenorrhea, which is a female condition involving ovaries (NOT present in 5ARD), ALL female 5ARD patients suffer from prim. ammenorrhea. Considering the possibility of a present uterus in these patients (rare, often lower portion of the "uterus"), I can imagine estrogen influences (e.g. anticonceptive pills) appearing as mentrual bleeding. Mentrual bleeding is (in my knowledge) not considered as a-menorrhea. These bleedings will always be without an egg cell because there are no ovaries. So summarizing: male 5ARD will most likely be infertile, female 5ARD will most likely have primary amenorrhea. What do you think? Chbse research student of intersexuality and gender identity 08:56, 12 October 2007 (UTC)

text: Adding to the "often" problem: might suggest that virilisation can be the primary problem. Still needs some refitting though...
research student of intersexuality and gender identity 08:56, 12 October 2007 (UTC)
thread_title:  Primary amenorrhea 

message: This is going off on a tangent here, but I'm curious as to whether Dihydrotestosterone (DHT) plays any known role on disorders such as Color Blindness, Hypertrichosis, or Fragile-X syndrome.  The article makes it quite clear that men with 5-Alpha Reductase Deficiency (5αRD) do not experience male-pattern baldness, due to lack of DHT (with its scientifically-established role in baldness.)
I'm curious, though, as to whether any research --and not just speculation-- has been pursued with 5αRD's role in other X-linked diseases.  I'm also curious about women with 5αRD.  While that is definitely not an intersex condition, I can't help but wonder if any verifiable studies have shown a lack of female-pattern baldness among them.
If so, it could potentially add-in a whole new dimension to the article. Pine (talk) 21:53, 15 August 2008 (UTC)
replies: text: I don't think a lot of research is done concerning 5αRD, other than sex organ effects (eg. intersex;DSD), but I'll look into it and report back. Chbse 10:16, 18 August 2008 (UTC)
replies: text: So far found on 5ARD: "The mutation appears to be silent in women. Homozygous 46,XX subjects with 5-alpha-reductase 2 deficiency are phenotypically normal, and have normal menstruation and normal fertility" src: UpToDate  —Preceding unsigned comment added by Chbse (talk • contribs) 16:09, 29 August 2008 (UTC)
thread_title:  How does 5αRD affect X-linked genetic disorders? 

message: ===Local names===
The term Guevedoche or Guevedoces is Spanish slang for the condition. It originated in the Dominican Republic, where more than three dozen cases have occurred in the small village of Salinas, all descended from a single individual named Altagracia Carrasco. It stands for the colloquial  expression huevo a los doce, which translates literally as "eggs at twelve" ("eggs" being a common slang term for "testicles"). It is also known locally as Machihembras (literally "malefemale"). A similar cluster of cases among the Simbari of the Eastern Highlands of Papua New Guinea has the local name Kwolu-aatmwol ("female thing transforming into male thing").''
This was moved to the talk page as it violate WP:OR. Please do not return it to the article without proper citations. -- 174.253.9.190 (talk) 20:39, 17 May 2011 (UTC)
thread_title: Original Research

message: :The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion. 
The result of the move request was: moved. (closed by non-admin page mover) Elli (talk | contribs) 04:13, 24 August 2021 (UTC)
replies: text: 5α-Reductase deficiency →  – This deficiency is specific to the isozyme, despite the fact that it is left out in many articlers. "2" needs to be in proper name of article rather than redirect. Highly cited sources that focus on the subject (788 cites): Steroid 5α-reductase 2 deficiency, (~55 cites, but more recent) Steroid 5α-reductase 2 deficiency. Some other highly cited sources use an extra hyphen (323 cites): "Androgens and male physiology the syndrome of 5α-reductase-2 deficiency". Recent review uses "Steroid 5α-reductase 2 deficiency". Other source add in "type" in the name. "5α-Reductase 2 deficiency" is simplest and maps to a good set of highly cited and recent high quality sources. Maneesh (talk) 00:00, 7 August 2021 (UTC)

text: — Advertised at WikiProject Molecular Biology/Genetics.--23:43, 16 August 2021 (UTC)

text: — Advertised at WikiProject Medicine.--23:43, 16 August 2021 (UTC)
replies: text: I went back and forth for a bit...but I now think "Steroid 5α-reductase 2 deficiency" is best.  "Steroid" is in the one of the (1700+ cites) seminal works and in two of the citations above. Maneesh (talk) 03:54, 17 August 2021 (UTC)
thread_title:  Requested move 7 August 2021 

message: The redirect Talk:5?-Reductase deficiency has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  TartarTorte 16:46, 8 June 2023 (UTC)
thread_title:  "[[:Talk:5?-Reductase deficiency]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] 

message: The redirect DHT insensitivity syndrome has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at  until a consensus is reached.  (t · c) buidhe 14:00, 30 August 2023 (UTC)
thread_title:  "[[:DHT insensitivity syndrome]]" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]]