Talk:Baclofen

message: This article doesn't say what the standard range of doses is, nor does it give the typical amount for an overdose.  — 86.1.163.237 (talk) 09:46, 21 September 2008 (UTC)
thread_title:  Dosage 

message: The section reads like an advertisement for Ameisen's books. If Baclofen is indeed useful for addiction treatment, this should be supported with relevant citations, and without continual reference to what is clearly a commercial venture.  —Preceding unsigned comment added by 173.55.161.108 (talk) 07:29, 18 June 2010 (UTC)
replies: text: At least with regard to alcohol addiction, the current version is clearly biased.  It places the relevant section before more basic information, makes unsupported assertions, and says "Regrettably" when stating the fact that most scientists haven't seen this theory as being worth mention. I've tried to clean up the major violations. JamesMLane t c 08:25, 26 March 2009 (UTC)
replies: text:  Russian cokeheads and tweakers use this stuff, religiously. But, as you may have guessed, NOT to treat addiction. Rather, it's reportedly a heavy stimulant abuser's best friend after a long binge, relaxing their jitters and letting them sleep. Doesn't do a thing to make them lay off the coke or meth, though, and hardcore users may use it at high dosages on a daily basis! Aadieu (talk) 08:59, 27 April 2010 (UTC)
thread_title:  Addiction 

message: In the introduction, it says baclofen is an agonist for GABAB receptors, yet the "Mechanisms of Action" says it's an allosteric modulator. However, the mechanisms of action bit isn't referenced - the only thing that is referenced is the GHB bits. I looked up my Rang and Dale Pharmacology text and it says baclofen is a selective GABAB receptor - anyone got other sources to back this up? 123.211.190.87 (talk) 03:33, 13 June 2011 (UTC)
thread_title: So, is it a modulator or agonist?

message: Many sections have an Unreferenced section tag.  However, all articles about
pharmacology contain references to the nih pubchem db and others.  Should we bother with littering such articles with unreferenced tags, when most references are practically implied?  I agree it's a boring job to add the deep links, and as an example I added references to Pubchem entries for each mode of administration for this particular drug.
(I had to lookup an entry for the oral mode, just reused the one in the box for intrathecal mode).
Maybe we just need some macros for this type of thing.
Henk Langeveld (talk) 23:46, 12 March 2012 (UTC)
replies: text: I agree, and here is another seemingly pointless tag example: "Historically baclofen was designed[by whom?] as a drug for treating epilepsy. It was synthesized for the first time in Ciba-Geigy by the Swiss chemist Heinrich Keberle in 1962." It seems a read of the second sentence would answer 'by whom'. JascalX (talk) 01:13, 5 June 2012 (UTC)
thread_title: Aren't some references already implied?

message: The reference of:
Autism
In 2012, baclofen was suggested for treatment of autism.[11]
^ "Half Of Children With Autism Wander, Study Says". http://huffingtonpost.com.+October 7, 2012.
seems not to say anything about Baclofen or a connection between Baclofen and Autism!?
86.33.158.14 (talk) 14:46, 4 January 2013 (UTC)
replies: text: I have simply removed the statement for now.  If there is information about the use of baclofen for treating autism that can be referenced to a WP:MEDRS-compliant source, then it can be added back in.  -- Ed (Edgar181) 16:03, 4 January 2013 (UTC)
replies: text: I believe this refers to the clinical trial of arbaclofen, which I think is a variant of Baclofen, for the treatment of Autism by the company Seaside. Reference here: http://www.nytimes.com/2013/06/07/business/an-experimental-drugs-bitter-end.html?hp&_r=0 18.93.14.48 (talk) 14:30, 7 June 2013 (UTC)

text: No it isn't. Look at Cheryl Cole's, Deal or No Deal, Glasto Festival to name just 3 Wythy (talk) 14:43, 12 November 2016 (UTC)
thread_title:  Reference to Autism claim wrong 

message: Listen to your gut
http://ajcc.aacnjournals.org/content/15/6/611.full
http://www.ncbi.nlm.nih.gov/pubmed/16454779
http://www.baclofenpump.com/living/during-treatment/underdose-overdose/index.htm
http://emj.bmj.com/content/22/9/673.full
http://www.mywayout.org/community/f20/baclofen-great-drug-but-also-extremely-deadly-60370.html
http://www.drugs.com/baclofen.html
http://multiple-sclerosis.emedtv.com/baclofen/baclofen-overdose.html
This Sheise is bananas...  — Preceding unsigned comment added by 173.217.250.87 (talk) 18:37, 19 June 2014 (UTC)
replies: text: No it isn't. Look at Cheryl Cole's, Deal or No Deal, Glasto Festival to name just 3 Wythy (talk) 14:43, 12 November 2016 (UTC)
thread_title: This is the worst page on wikipedia

message: "There are very few cases of abuse of baclofen for reasons other than attempted suicide.[6]".
If there are only a very few cases of attempted suicide with Baclofen then this sentence needs to be reworded.  
"Baclofen produces its effects by activating the GABAB receptor, similar to the drug phenibut which also activates this receptor and shares some of its effects. Baclofen is postulated to block mono-and-polysynaptic reflexes by acting as an inhibitory neurotransmitter, blocking the release of excitatory transmitters. However, baclofen does not have significant affinity for the GHB receptor, and has no known abuse potential.[12] "
First, what does in the first part of the section imply baclofen having an affinity for GHB receptor, that we need to say it does not? That sentence seems irrelevant, since GHB (which does bind to GHB receptor) is not even mentioned in the preceding sentences. Second, how is it that baclofen "has no known abuse potential" if the it causes a very serious benzodiazepine-like withdrawal syndrome and is a well-known drug of abuse in Russia (as stated in the article itself)? --78.84.59.209 (talk) 20:29, 26 March 2016 (UTC)
thread_title:  Needs editing 

message: I check pages listed in :Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of :Baclofen's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "chou":
From Cyclobenzaprine: 
From Antispasmodic: 
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 07:46, 7 January 2018 (UTC)
thread_title:  Orphaned references in [[:Baclofen]]