lflage/wiki-talks huggingface dataset:
Talk:Sulfacetamide

message: “It is practically non-toxic and also not an irritant when taken in orally. However, it is very hazardous in case of skin contact (irritant), ingestion and inhalation.”
I’ve tried to read that couplet of sentences a thousand times without coming to the conclusion that it suggests that this drug is totally benign when taken by mouth, but toxic as hell when swallowed, inhaled or even touched. Is anyone aware of how you can take a drug by mouth without touching or ingesting it? Alanrobts (talk) 22:51, 27 April 2021 (UTC)
thread_title:  Paradox?
Talk:Miss Teen America

message: This is amazing. For all of the monster stage moms who want their kids to have press, you'd think this article would at least have the actual history of the competitions.
Interesting.  — Preceding unsigned comment added by 67.243.200.24 (talk) 02:09, 5 June 2019 (UTC)
thread_title:  Surprisingly sparse
Talk:Sulindac

message: Guys, if something broke, I'm sure there's a venue in which to find help -- search a little. I found an easy way to fix this, then a right way to fix this. Neither involved leaving a message on the main page that it had broken. The  and  tags helped work around the problem of the complex [[ problem. Thanks for fixing the name, though! --Thatnewguy (talk) 11:41, 5 December 2008 (UTC)
thread_title: Knowing when to ask for help

message: I changed:
:"Bartlett v. Mut. Pharm. Co., Inc., 678 F.3d 30, 34 (1st Cir. 2012)."
To:
:{{cite court
:|litigants= Bartlett v. Mut. Pharm. Co., Inc.
:|vol=678
:|reporter=F.3d
:|opinion=30
:|court=D.C. Cir.
:|date=March 19, 2013
:|url=https://www.law.cornell.edu/supct/cert/12-142
:|accessdate=Sept 3, 2017
:}}
I'm not a lawyer, so is this correct in terms of which numbers are where?   Is there a "preferred" case law site to use?  There is also a PDF link here that should be more stable as it is supremecourt.gov.. (I'll refrain from a joke regarding current U.S. politics.) Jimw338 (talk) 03:04, 4 September 2017 (UTC)
thread_title:  Is my cite court tag for "Bartlett v. Mut. Pharm." correct?
Talk:Oxygen minimum zone

message: Implemented "Changes" section into the article to help readers understand the fluctuations and changes in the OMZ over time. Plan to implement other sections of the article that were created by the Oregon State University group. Hubertub (talk) 17:59, 5 March 2020 (UTC)
thread_title:  "Changes" 

message: I don´t think "shadow zone" is used correct. In my view "shadow zone" means that this is the zone in which there is not much light (no photosynthesis possible). It is the same deep as the oxygen minimum zone is, but it is not the same. --Goldzahn (talk) 04:35, 24 April 2014 (UTC)
thread_title:  "shadow zone" 

message: I've moved the content about the impacts of climate change to ocean deoxygenation because similar content was spread over three articles (here, at ocean deoxygenation and also at microbiology of oxygen minimum zones. I am consolidating this information into one place now at ocean deoxygenation. Will later replace the paragraph that I've left behind with an excerpt from ocean deoxygenation. EMsmile (talk) 07:58, 5 July 2023 (UTC)
thread_title:  Moved content about impacts of climate change
Talk:Hawk (plasterer's tool)

message: Where does the name Hawk come from, why is this tool called that? This has been bothering the people I work with and myself for some time. — Preceding unsigned comment added by 207.179.175.182 (talk) 03:13, 2 March 2007 (UTC)
thread_title:  Origin of name 

message: According to Partridge's (whom one might expect to be authoritative on the subject), the bird takes its name from Old English "hafoc" (whence "havoc") meaning to heave or heft.  Modern English still preserves the verb "hoik" with the same meaning of lifting or throwing up a weighty object.  210.50.143.21 (talk) 21:02, 3 November 2010 (UTC)
thread_title:  Etymology 

message: I agree that in use a hawk looks like a FALCON, but did they ever use hawks for falconing? I think the profile of a hawk when you set it down is much like the profile of some birds of prey. The handle will take the position of the bird's legs, and the sloping square will form the bird's body to its tail below the legs/handle and up to its head or high over-sloping shoulders above the legs/handle. A photo of a hawk in profile might show this better than the full-face portrait that is there now.2604:2000:C682:2D00:7413:2650:321E:B740 (talk) 19:15, 25 August 2018 (UTC)
replies: text: They did use hawks, such as the goshawk, for falconing. That's why the verb "hawk" means to catch something using a bird of prey trained for the purpose. Also, true falcons are sometimes called hawks, "sparrow hawk", "pigeon hawk", "duck hawk", "prairie hawk"...  Of course, this is all irrelevant as I'm pretty sure that the superficial resemblance is coincidence. Partridge's etymology from "hafoc" (to heave) is much more likely. 24.16.239.30 (talk) 11:09, 30 December 2023 (UTC)
thread_title:  Illustrations
Talk:Talizumab

message: this drug wouldn't just prevent small reactions of peanuts, it would work for whatever a particular person would be allergic to, peanuts allergies are just common67.171.69.23 17:37, 5 December 2006 (UTC)
thread_title: December 2006, merged from TX-901

message: Ran across a hopeful article on TNX-901 and it's positive effect -- some might even say "cure" -- on the plight of peanut allergy sufferers in an old Reader's Digest. Caught my eye because a friend has this highly dangerous allergy. Came on-line to see what the current status was and was horrified to learn that, once again, corporate greed outweighs human life. Essentially, two large drug companies reneged on an agreement with their third partner and blocked further development of a drug that was shown to prevent anaphylactic shock (affecting tens of thousands annually, killing hundreds in the process). Why? Because their management teams were afraid that this new drug _MIGHT_ compete with a drug they already had on the market that is NOT approved for this purpose by the FDA (it's an asthma drug); nor has it been shown to be effective for this condition. But it does costs four figures a month. We certainly wouldn't want to jeopardize that possible future cash flow to save a couple hundred people a year and prevent the suffering of thousands more, eh? 71.188.227.62 (talk) 06:37, 11 July 2012 (UTC)
thread_title:  greed reigns 

message: This is an article about an antibody, not a general treatise on greed.  — Preceding unsigned comment added by 18.56.5.92 (talk) 21:56, 23 January 2013 (UTC)
thread_title:  POV 

message: The earlier opinions focus on the greed of giant pharmaceutical or biotech companies and their insensitivity to the desperate need of patients with severe allergy to peanut. The present form of TNX-901 provides many articles from major media publications to deal with the "greed" topic. The discussion in the TNX-901 article is rather balanced in its present form.  — Preceding unsigned comment added by PeaceRock (talk • contribs) 01:36, 15 March 2013 (UTC)
thread_title:  A balanced view in its present form
Talk:Trandolapril/verapamil

message: Please accept the edits to this page (February 13, 2013). My name is Scott Stoffel, and I work at Abbott in Corporate Public Affairs, and the edits I am providing are all factual, based upon review of the page with Abbott Laboratories scientists who have expertise in this area. If you have questions, please do not hesitate to access my contact information, found here: http://abbott.com/news-media/contacts.htm  — Preceding unsigned comment added by ScottStoffelAbbott (talk • contribs) 14:18, 13 February 2013 (UTC)
Talk:Pat Dolan

message: Please explain how Pat Dolan was Born September 20, 1967 Ardrahan, Galway yet his twin brother [Eamonn Dolan] was born September 20, 1967 in Dagenham.  —Preceding unsigned comment added by 78.16.89.251 (talk) 20:57, 4 December 2007 (UTC)
thread_title: Untitled

message: Perhaps it could be added that Pat seems to have had a hair transplant of some kind. In the TV ad for the Star newspaper Dolan's hair is seen to be thinning at the side, yet on TV he appears with the full barnet. Could be worthy of investigation and inclusion into the artice  —Preceding unsigned comment added by 89.100.45.62 (talk) 17:24, 4 January 2009 (UTC)
thread_title:  Hair 

message: Perhaps we should get a reference for his role as "advisor to Diego Maradona"  —Preceding unsigned comment added by Philip861 (talk • contribs) 00:14, 23 August 2009 (UTC)
thread_title:  Maradona
Talk:Joy Turner

message: I don't think they exactly belong here and they're long, stupidly taking up a big chunk of the page. Any disagreement? Ayavaron 03:20, 2 March 2007 (UTC)
thread_title:  Quotes? 

message: I moved the page to Joy Turner, since this what she is referred to on the show since season 1. I hope that's alright with everyone. Sfufan2005 00:13, 20 October 2007 (UTC)
thread_title: Moved page
Talk:Teicoplanin

message: A summary of the clinical trials of Teicoplanin would be useful. - Rod57 (talk) 08:33, 2 September 2011 (UTC)
thread_title:  clinical trial results 
Talk:Telmisartan

message: I do not like this sentence. Telmisartan is mostly an anti-HTN drug, its use/role at heart failure or CKD is not as notable as its role at HTN. Also, and more importantly, it is not used as a treatment of HF or CKD, it is used in the management of those to diseases. I would have change the sentence to "" but since it is the first sentence, I need your opinion...Cinadon36 20:16, 25 November 2019 (UTC)
thread_title:  "Telmisartan, sold under the trade name Micardis among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease" 

message: Telmisartan has a PPARg-agonist- activity It says so at Opie, 8th edition, 2013, p171. I am not sure if we should state it at the article as it is mentioned in a secondary sentence... I feel the PPARg-agonist activity is really low. Same page says that telmisartan "reduced new-onset electrocardiographic LVH by 37%".Cinadon36 09:37, 26 November 2019 (UTC)
thread_title: PPARg-agonist activity of Telmisartan
Talk:Terconazole

message: Is there a test that can be performed to confirm that terconazole has been fully eliminated from your system / body?  If so what is it?  For example, several weeks after administration - negative side effects are still occurring.  Is the terconazole still in vagina, tissues, blood, other location? 2601:8A:501:410:84AD:35EF:27CC:CF50 (talk) 02:24, 9 August 2022 (UTC)
thread_title:  Is there a test that can be performed to confirm that terconazole has been fully eliminated from your system / body? 

message: Terconazole is an antifungal drug used to treat vaginal yeast infection. It comes as a lotion or a suppository and disrupts the biosynthesis of fats in a yeast cell. It has a relatively broad spectrum compared to azole compounds but not triazole compounds. Testing shows that it is a suitable compound for prophylaxis for those that suffer from chronic vulvovaginal candidiasis. 71.38.84.232 (talk) 04:24, 18 November 2022 (UTC)
thread_title:  Hey
Talk:Stardust (magazine)

message: The article claims that "It became popular under the editorship of noted journalist, author and columnist, Shobhaa De after 1995." There are specific references to Stardust being the most read film magazine that predate 1995. For example, in an article from the New York Times, September 6, 1992, titled "Steamy Magazine Coverage Steaming Up Actors in India," in which actors are upset at their personal lives being discussed threadbare in cine magazines: "The most disliked magazine is Stardust, the country's largest circulation, English-language film gossip magazine. Mr. Kher's anger was directed at Troy Rebeiro, a reporter at Stardust, who received the stinging slap."
Stardust was popular long before Shobha De ever came on the scene. Still, I am not going to make a change until someone responds here. --Hunnjazal (talk) 20:06, 11 April 2015 (UTC)
thread_title: Popular under Shobha De?
Talk:Terfenadine

message: More discussion about the controversy surrounding terfenadine would be nice. I believe that it was this drug that prompted the FDA to enact new rules so drug makers would take into account which CYP enzymes metabolize a candidate drug, so that potential drug-drug (or drug-food) interactions can be anticipated.   Could someone put up the narrative story?   --74.179.112.79 (talk) 22:24, 10 October 2010 (UTC)
thread_title:  Controversy Discussion
Talk:Theraflu

message: Another product like Theraflu is the French procuct "Fervex" made by UPSA CONSEIL.
My box of Neo Citran says it still contains real pseudoephredrine.  — Preceding unsigned comment added by 74.216.60.82 (talk) 22:35, 6 November 2011 (UTC)
thread_title:  other product is the French "Fervex" made by UPSA CONSEIL 

message: the article states that the swiss and canadian version is sold as NeoCitran.
this is - at least since 2014 - not true.
NeoCitran is indeed manufactured by Novartis, but does not include Pseudoephedrin.
The same brand is sold in Austria too, also without Pseudoephedrin.
(consisting of: paracetamol, ascorbate,"Phenylephrini hydrochloridum" and "Pheniramini hydrogenomaleas")
http://www.swissmedicinfo.ch/
62.2.83.2 (talk) 21:36, 3 March 2015 (UTC)
thread_title:  NeoCitran
Talk:Tremelimumab

message: ASTRAZENECA’S COMBINATION OF DURVALUMAB WITH TREMELIMUMAB SHOWS CLINICAL ACTIVITY IN NON-SMALL CELL LUNG CANCER IRRESPECTIVE OF PD-L1 STATUS. Phase III trials ongoing. - Rod57 (talk) 00:13, 9 February 2016 (UTC)
replies: text: As reported at , this is a phase Ib study (study 006), which means it's an early exploratory study.  According to the content guideline WP:MEDRS, unless there is a particular reason for an exception, this report is completely and utterly irrelevant in this encyclopedic concept space, until further information develops. By convention, people are free to put whatever preliminary speculations or outright rubbish they want on Talk pages. Other editors are then free to come along and criticize the embarassingly poetic fancy of placing premature, naive, buzzing gossip here. This response denounces without reservation this wobbly reference as a (presumably unintentional) bewilderingly misguided promotion of a particular commercial confection, which has not been adequately tested. As a relevant comparative benchmark, there are several approved medications within the immunotherapy concept space, making this reference all the more flagrantly speculative and contextually unscrupulous. FeatherPluma (talk) 17:45, 5 March 2016 (UTC)
thread_title:  NSCLC trial results Feb 2016
Talk:Immensa aeterni Dei

message: This is not an article about a saint. So why is it classified as a stub about a saint?
PAlban 04:27, 14 September 2007 (UTC)
thread_title:  No saint 
Talk:Tienilic acid

message: Yhe above explanation is an hypothesis. It is still not known (after 15 years) if the reactive intermediate which inactivate the CYP2C9 is the thiophene sulfoxide or the thiophene epoxide. The target on the protein is also not known (could be multiple). However tieilic acid is a good mechanism based of CYP2C9 and seeems to inactivate it stoechiometrically. Progress in proteomics may one day give the answer.  —Preceding unsigned comment added by 212.198.143.165 (talk) 22:29, 1 July 2008 (UTC)

message: The current paragraph 4 does not make sense is there something missing? It is currently "In addition sera of patients who had liver failure after taking this drug contained antibodies recognizing CYP2C9 able to hydroxylate the drug and to give covalent binding."
There seems to be something missing immediately after "CYP2C9"
Seuraza (talk) 01:44, 28 July 2020 (UTC)
thread_title:  Paragraph 4
Talk:Timolol

message: Timolol + travoprost/ Timolol + Brimonidine are available in preservative free formulations in India by the trade name Travoprostin T and Brimoeye T by Eyekare Kilitch Ltd, Mumbai.  — Preceding unsigned comment added by 1.22.44.132 (talk) 07:31, 21 May 2015 (UTC)
Talk:George Hilsdon

message: The text says 108 goals in 134 appearances yet the recorded League record says 99 goals in 150 appearances.
This can't be right. 
I just checked his stats on http://thechels.info/wiki/George_Hilsdon and he played 164 games in total
90.248.206.190 (talk) 17:49, 3 March 2019 (UTC)
thread_title:  Chelsea record?
Talk:Tizanidine

message: Unfortunately I don't have anything to contribute, but this is quite possibly one of the most poorly written sections I've ever read on Wikipedia. It could at least be turned into a list, rather than the mammoth barely-readable paragraph it is right now.  — Preceding unsigned comment added by 101.171.190.188 (talk) 12:49, 13 November 2011 (UTC)
replies: text:  Agreed...  seriously, the pill descriptions are overkill and incredibly clumsy. --Cabazap (talk) 05:29, 19 December 2011 (UTC)
thread_title: Availability

message: Why are the pill descriptions in there at all?  there was talk about them earlier but they're still there.  There are hundreds of different pill types out there.  Should descriptions be listed for all available formulations for all pharms????  — Preceding unsigned comment added by 216.105.208.2 (talk) 07:37, 16 August 2012 (UTC)
thread_title:  Pill Descriptions?? 

message: removing the Kg from the L/Kg for volume of distribution.  I recall from pharmacology (and confirmed by going to the Wikipedia page :-) <ref>http://en.wikipedia.org/wiki/Volume_of_distribution<ref>) Volumes of distribution are given only in units of L, there isn't a mass component to the unit.Miniapolis 02:09, 11 December 2018 (UTC)
thread_title:  Interactions 

message: The article currently says, in the Side Effects section:
Tizanidine has drug abuse potential. It has been recognized to cause dependence and addiction.
But this is not supported by the source. The source says nothing of dependence or addiction. It also doesn't say anything of abuse potential: it simply says that of the (fatal) poisonings in their database, of those that involved a pharmaceutical without a prescription, that tizanidine was implicated in some number of those. It does not distinguish poly-drug combinations, especially with illegal drugs, nor cases of intentional drug overdose. Number of deaths where the person had tizanidine in their system does not equate to abuse potential.
There is physical dependence, analogous to how clonidine has physical dependence, but this is not related to addiction potential / psychological dependence potential.
I am going to remove the above quoted text. If someone wants to re-add it, please use a source supporting the claim directly.
Kimen8 (talk) 22:37, 27 January 2024 (UTC)
thread_title:  Abuse potential
Talk:Tocilizumab

message: Removed link to tocilizumab.com, which seems to be purely a collection of sponsored links, and not an official site.  81.107.41.207 (talk) 12:30, 21 March 2008 (UTC)
thread_title: Untitled

message: The LITHE trial was reported extensively, but there have been several other phase III trials. http://arthritis.about.com/od/brms/a/actemra.htm sums them up. JFW | T@lk 10:25, 31 October 2008 (UTC)
thread_title:  Five trials 

message: Is not really needed. It is in the reference. Doc James (talk · contribs · email) 23:11, 9 April 2020 (UTC)
thread_title: "at 11 locations in China"

message: "This ability to counter cytokine release syndrome, also known as a cytokine storm, enables the use of Tocilizumab to treat the  most extreme cases of COVID-19."
We need a proper reference. No we do not have evidence that this treats the most extreme cases... Doc James (talk · contribs · email) 02:53, 15 April 2020 (UTC)
thread_title: Text
Talk:Tofisopam

message: The other optical isomer unexpectedly lowered serum urate, which led to clinical trials for gout. --Nbauman (talk) 20:39, 15 December 2012 (UTC)
thread_title:  levotofisopam 

message: US Patent 5288863 gives a large series of homologues. It seems that the molecule is optimized apart from substitution of the benzene ring and that an EWG at the 2 position gives the strongest analogues (x3.77 stronger than tofisopam). The chemistry appears to use lithium perchlorate etherate for ring-expansion (O swapped for hydrazine). Friskly perchlorates are NOT something to be taken lightly.  — Preceding unsigned comment added by Dvwynn (talk • contribs) 13:41, 26 October 2014 (UTC)
thread_title:  Analogues 
Talk:Tolcapone

message: This is not a joke: I attended the University of Kansas Medical Center, where the namer of this drug once worked. It was well known at the institution that this person was an Al Capone fan. He later worked for the drug company that developed Tolcapone. There was an employee contest to name the drug and his Al Capone-inspired appellation won. Tolcapone was born. This is, of course, "original research." I'm hoping the Wikipedia folks will overlook this.
:Is there a reliable source that confirms this?  ... discospinster talk 20:08, 29 August 2010 (UTC)
thread_title: Capone

message: I removed the technical flag after rewriting the 2008 synthesis as a narrative that describes the purpose of each step. This should make it slightly clearer for readers with the necessary background knowledge. Roches (talk) 08:41, 21 April 2015 (UTC)
thread_title:  Synthesis
Talk:Tolnaftate

message: Did John Madden 'endorse' tolnaftate or one of the brand name products? It seems unlikely a generic chemical would be 'endorsed' by a celebrity (or anyone). Citation requested. 24.7.178.142 (talk) 02:54, 19 June 2008 (UTC)
replies: text: He's done a commercial for tinactin "Boom! touch actin tinactin" http://www.youtube.com/watch?v=Pg1H9PBwLp4 but through endorsing this product which uses Tolnaftate as an active ingredient so in a sence he is advocating, or "endorsing" Tolnaftate.  I'd change it to something like "John maden has been known to do commercials for a popular, brand-name anti-fungal product line, a line of products based on Tolnaftate." or what ever.  I'd avoid listing the brand name with out listing several brand names in the same article.  —Preceding unsigned comment added by Xetxo (talk • contribs) 22:10, 2 February 2009 (UTC)
thread_title:  Madden continued 

message: A Labol for a foot powder I bought says to "store between 15C and 25C, is this substance temperature sensative at all?Xetxo (talk) 22:16, 2 February 2009 (UTC)
thread_title:   temp sensative?
Talk:Tolvaptan

message: Oops, not quite effective in heart failure, but some short-term benefits observed. JFW | T@lk 14:27, 25 March 2007 (UTC)
thread_title:  JAMA 

message: Tolvaptan is a racemic small molecule drug (Molecular Weight of 448.9 g.mol-1) and is a lipophilic drug, is essentially insoluble in water, and has fair oral absorption (>40% bioavailable). Tolvaptan hsa a plasma half-life of around 12 hours, a volume of distribution of 3L/kg, and has high plasma protein binding at 99%. Tolvaptan is extensively metabolised by 3A4, and therefore has many concommitent interactions with 3A4 substrates, inhibitors and inducers. Reportedly, Tolvaptan metabolites show no appreciable pharmacology against the vasopressin receptors. Interestingly, Tolvaptan is a racemic drug, with the two enantiomers showing differing PK/PD. Typical daily dosing is 30mg (or ~67µmol), or 60mg if insufficient efficacy is observed.
The compound shown is not Tolvaptan based on this information  —Preceding unsigned comment added by ChemSpiderMan (talk • contribs) 13:40, 8 June 2009 (UTC)
replies: text: Confirmed, based on Merck Index 14th Ed, entry 9540, Tolvaptan is a racemic compound and so the structure image for this record needs revising. --The chemistds (talk) 13:48, 9 January 2012 (UTC)
thread_title:  Racemic drug 

message: Link 2 is broken: http://www.medicalnewstoday.com/medicalnews.php?newsid=38392 apers0n (talk) 17:42, 23 February 2014 (UTC)
thread_title:  Broken link 

message: I have removed the primary literature on this subject. It would be good to add some tertiary literature on this topic, e.g. from here. ―Biochemistry🙴❤ 20:21, 3 May 2019 (UTC)
thread_title:  Polycystic Kidney Disease