Talk:Chlorphenamine

message: I think the correct spelling is chlorpheniramine. Can we get a correction?  LVehko (talk) 19:47, 26 April 2010 (UTC)
replies: text: Chlorpheniramine is a former name, it's now known as chlorphenamine. Chlorphenamine is internationally known (INN), and is a former BAN name.  — Preceding unsigned comment added by 2a02:c7d:7608:e700:3cb8:8763:2ec5:44b4 (talk • contribs)  16:52, 16 June 2016 (UTC)
thread_title: There is no such thing as 'chlorphenamine'

message: A straight copy-paste from http://www.answers.com/topic/chlorphenamine
Actually, moron, if you read the page, answers.com copied and pasted from Wikipedia!  It's very clearly cited at the bottom.  —Preceding unsigned comment added by 198.108.140.10 (talk) 05:45, 11 September 2007 (UTC)
replies: text: Now now, insulting people isn't nice. Please be polite. An uninformed individual might think that answers.com is more official and reliable than Wikipedia, but Wikipedians know better. Fuzzform 23:09, 31 October 2007 (UTC)
thread_title: This was plagarised

message: The articles diphenhydramine and zimelidine claim that diphenhydramine, not chlorpheniramine, was used as a model for zimelidine. However, googling returns 146 matches for chlorpheniramine zimelidine, or 21 for chlorphenamine zimelidine (Swedish 12 for klorfeniramin zimelidin) but only 119 for diphenhydramine zimelidine (Swedish 13 for difenhydramin zimelidin). Which should it be? On Wpedia diphenhydramine is the one most mentioned.
Where next Columbus? 00:29, 17 December 2005 (UTC)
replies: text: As I understand it, zimelidine was synthesized from chlorpheniramine. But, as diphenhydramine is by far the most common antihistamine (and probably also the basis for the synthesis of chlorpheniramine, although I haven't seen any papers confirming that), it may as well be said that zimelidine was based off of diphenhydramine. In other words, chlorpheniramine was an intermediate between diphenhydramine and zimelidine. Fuzzform 23:07, 31 October 2007 (UTC)
replies: text: Actually, it was brompheniramine that was the basis for zimelidine. See (circa) page 50 in Baronde's book "Better Than Prozac". 24.218.74.249 (talk) 04:31, 19 April 2008 (UTC)
thread_title: Which was the model for zimelidine?

message: Should this be on the antidepressant template under SSRIs?  It's already in the SSRI category, but it seems a little strange since it isn't used as an antidepressant.  Thoughts? --Galaxiaad 18:47, 6 November 2006 (UTC)
replies: text: I don't think so. As you say, it isn't used as an antidepressant. It's main use is as an antihistamine, and that's the template it belongs in. Fuzzform 23:00, 31 October 2007 (UTC)

text: Plus it's not an SSRI. The first S in SSRI is for selective. Reub2000 (talk) 02:51, 19 May 2011 (UTC)
thread_title: SSRI template/category?

message: Is this potent enough that people taking SSRIs or MAOIs etc. should avoid it?
:Unlikely. It's main effect is antagonism of histamine H1 (see antihistamine). Also, I'm about to update the image from png to svg. Note that the CH3 (methyl) groups about the nitrogen are implied in the skeletal formula and need not be written as such. Fuzzform 22:59, 31 October 2007 (UTC)
thread_title: SSRI potency

message: In the first paragraph which says that Chlorphenamine is a first-generation antihistamine, what does "first-generation" mean?
Cat Dancer WS (talk) 00:36, 28 January 2008 (UTC)
replies: text: Not used for allergies anymore?!?, are you crazy??? Ever heard of Benadryl??? You said this drug is the exeption but Benadryl is first generation and it is far more common and is still very widely used for allergies.--206.28.43.6 (talk) 20:37, 16 August 2008 (UTC)
thread_title: First-generation?

message: Okay, I'm a little puzzled. Chlorphenamine says it potentiates certain opioid analgesics (including codeine), but according to CYP2D6 chlorphenamine is an inhibitor of this P450 isozyme, while codeine is a substrate. Codeine states that it is a prodrug, being converted (via CYP2D6) into the active metabolites. 
How can chlorphenamine potentiate codeine when it inhibits the enzyme responsible for codeine's activity? --Jmcclare (talk) 03:30, 10 April 2008 (UTC)
replies: text: Antihistamines are certainly potentiators of opiods - no question about that. Either there is mistake in the CYP2D6 article, or there is some other (stronger/more important) mechanism to explain antihistamines' potentiation of opiods. 24.218.74.249 (talk) 04:36, 19 April 2008 (UTC)
replies: text: Not all anti-histamines are potentiators of opioid based drugs, in other words chemically, the opioid will have no greater effect whether taken with or without anti-histamines. The reason many people beleive anti-histamines potentiate opioids is due to their sedative effect, both opioids and anti-histamines are sedatives, together they produce stronger sedation. Also remember, codeine is only 1 type of an opioid drug, whilst many opioids do not need the liver to become active as they are active in their current form. There are only a few anti-histamines that potentiate codeine (& other metabolite based opioids) directly, the rest appear to potentiate due to the combined stronger sedation, when infact, chemically, no potentiation takes place. --93.97.181.187 (talk) 21:17, 19 October 2008 (UTC)
thread_title:  P450 Contradiction 

message: In the pharmacokinetic data, chlorphenamine has a stated half-life of 21-27 hours. However, standard Chlor-Trimeton and generics state that they are effective for 4 hours. There are 8 and 12-hour versions, but these are a sustained relief formulation. If it takes 21-27 hours for the body to metabolize and excrete 50% of a chlorphenamine dose, how can it no longer be effective after 4 hours? I don't see a citation on the article which would cover this half-life claim, so I wonder if it could be incorrect.
Can anyone clarify this or add a citation? Thanks. Josh274 (talk) 00:38, 10 June 2008 (UTC)
replies: text: Generally such info held by DrugBank link provided in the infobox, except DrugBank site currently seems temporarily down :-( David Ruben  Talk  13:22, 10 June 2008 (UTC)
thread_title:  Citation for half-life? 

message: Most first generation antihistamines have some level or another of anticholinergic action, and by viewing the similar chemical structure of this drug to diphenhydramine (Benadryl), which is a potent anticholinergic, I would assume that chlorpheniramine has considerable anticholinergic action as well. Is this known to be true? If it is it should be included in the article.--206.28.43.6 (talk) 20:43, 16 August 2008 (UTC)
thread_title:  Anticholinergic? 

message: I propose an addition to the combo-drug subsection. Deconamine, a combo-drug consisting of Chlorpheniramine and Pseudoephedrine.
*http://www.drugs.com/mtm/deconamine.html
*http://www.webmd.com/drugs/drug-15755-Deconamine+Oral.aspx?drugid=15755&drugname=Deconamine+Oral&source=1
*http://www.walgreens.com/marketing/library/finddrug/druginfo1.html;jsessionid=OMT9mjfv5heAhHOXxDaTIw**.p_dotcom55?particularDrug=Deconamine&id=1396
*http://www.drugs-expert.com/deconamine-chlorpheniramine-and-pseudoephedrine/
Bullmoosebell (talk) 00:04, 5 January 2012 (UTC)
thread_title:  Deconamine 

message: I know for a fact that Chlorphenamine is a Pharmacy only medication in the UK, so I changed it from GSL to P in the infobox. If the "P" term is not common Wikipedia practise, feel free to modify it to the appropriate term.  — Preceding unsigned comment added by Tomf60 (talk • contribs) 19:18, 7 September 2012 (UTC)
thread_title:  Legal status in the UK 

message: The formula C16H19ClN2 in the infobox does not seem to match the structure shown top right which only seems to have 14 C. The maleate ion has 4 C so is it possible that maleate is divalent and the formula is for half of the salt, ie chlorphenamine ion + half of shared maleate ion ? - Rod57 (talk) 14:11, 14 September 2015 (UTC)
replies: text: C16H19ClN2 is the correct formula and it does match the structure shown in the infobox which also has 16 carbons.  ChemNerd (talk) 16:54, 16 June 2016 (UTC)
thread_title:  Maleate -  formula vs structure diagram 

message: Apparently due to the increasing popularity of newer, longer-acting, less side-effect prone meidcations, the Chlor-Trimeton brand has been discontinued, and generic versions are now becoming more difficult to find in the US. The FDA determined specifically that there were no patient safety concerns, and the drugs withdrawal is due to decreasing market popularity. Perhaps add this information to the page somewhere? 108.32.35.126 (talk) 15:55, 18 April 2024 (UTC)
replies: text: The brand may be discontinued, but generic forms are widely available. On Amazon, there are 76 'brands' available. Amazon has its own Branded version. Do you have a source that states that it is becoming difficult to find?  cheers. anastrophe, an editor he is. 17:36, 18 April 2024 (UTC)
thread_title:  Chlor-Trimeton Discontinued, chlorpheniramine maleate difficult to find in US