Talk:Kinetic isotope effect

message: Two major errors are present.
1) There is currently no distinction between primary and secondary isotope effects. The kinetic isotope effect is simply the effect on the rate of the reaction of replacing one isotope with another.
A primary isotope effect occurs when bonds to the atoms in question are broken or formed during the rate-determining step of the reaction. A secondary effect is when the bond is broken/formed in a non-rate-determining step. The ratio of the rates of the lighter and heavier isotopes is indicative of whether the effect is primary or secondary. In H/D systems, primary effects have kH/kD (where k represents the rate constant) of 2 or more, while the ratio is 0.7-1.5 for secondary effects. For primary H/D effects, kH/kD values of greater than 20 indicate reliance of quantum mechanical tunnelling. Tunnelling is only a major factor for movement of H and electrons. 
2) As implied above in the discussion of secondary H/D effects, the heavier isotope does not necessarily slow the reaction.
This information can be found in Carey & Sundberg's Advanced Organic Chemistry: Part A, 4th ed. Kluwer, 2000. (This book has been reprinted under the Springer imprint since 2004, when Springer purchased Kluwer).
Denise 66.71.92.124 05:33, 16 December 2005 (UTC)
thread_title:  Errors in article 

message: The reviewer notes that it is relative mass change that dominates.  The reduced mass point of view is also helpful, but lss clear.  The problem is: Can we make a statement about both without again confusing the two issues? -- Pinktulip 18:56, 2 January 2006 (UTC)
thread_title:  What is being asked for 

message: Wikipedia has no entry for equillibrium isotope effects and they are not mentioned on this page. Should a new article be drafted or should an addendum be made to this one?12.217.244.228 (talk) 04:03, 11 March 2008 (UTC)
thread_title:  Equillibrium Isotope Effects 

message: Hi User:Dirac66, I removed the lines stating the necessity of KIE's appearing in the RDS, because depending on how the experiment is done (see Expts B and C, inter and intramolecular competition experiments) the KIE can be observed even if it happens after the RDS.  The specialist literature is replete with examples of that.  Please see Simmons and Hartwig's recent Angew. Chem. review for the distinction between the three kinds of KIE experiments.  https://www.ncbi.nlm.nih.gov/pubmed/22392731.  In short, only the first type of experiment where overall rate constants are measured necessarily pertain to the RDS. Alsosaid1987 (talk) 06:54, 8 December 2018 (UTC)
thread_title:  KIEs are not necessarily observed only in the RDS 

message: While trying to find sources for a report I'm writing I found that source 40 " Kwan E. "CHEM 106 Course Notes - Lecture 14 - Computational Chemistry" (PDF). Retrieved 2 November 2013." no longer links to a usable page.
The link http://isites.harvard.edu/fs/docs/icb.topic1312284.files/Lecture%2014%20-%20Computational%20Chemistry%20II.pdf
Leaves me to a page telling me: The iSites platform has been retired.
Is it possible for someone to retrieve a working version of this link or is it lost to time and should be removed?
--Speederzzz (talk) 12:37, 29 June 2021 (UTC)
thread_title:  Dead link in sources