Talk:Silibinin

message: The last para of this article states:
"Silymarin is among the popular complementary medicine for the treatment. "
This doesn't make sense to me - could someone rephrase?
Smalljim 13:19, 7 February 2007 (UTC)
thread_title:  treatment of what? 

message: A few comments, additions and citations to this entry.  First, there is an entire journal issue devoted to the uses of silymarin in cancer (breast, skin, prostate, etc).  See Integrative Cancer Therapies 6(2) 2007.  For example: Deep G & Agarwal R. Chemopreventive Efficacy of Silymarin in Skin and Prostate Cancer.  Pgs 130-145 of that journal will give you the citation you need for skin/prostate cancer. 
Also, several articles on the use of SIL in diabetes and the prevention of diabetic neuropathy (when the retina and peripheral nerves are destroyed): 
Gorio A, et al. Alterations of protein mono-ADP-ribosylation and diabetic neuropathy: a novel pharmacological approach. Eur J Pharmacol 1996; 311: 21-28
McCarty M. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Med Hypotheses 2005; 64: 628-35.
Velussi M, et al. Long term (12 mos) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. Jour Hepatol 1997; 26: 871-79.
Lastly, since the recommended dose for Amanita toxicosis in dogs is 50 - 150mg/kg, I doubt that the LD50 in dogs is 140 mg/kg.  I would be very interested in seeing the citation for those tox numbers, since I have not found any such toxicities in my research.  Since my thesis is on the uses of SIL in pets, such info would be very useful.  The citation for that dosage, btw is:
Filburn CR, et al. Safety and bioavailability in beagles of zinc and vitamin E combined with silybin and phosphatidylcholine. Intern J Appl Res Vet Med 2006; 4(4): 326 - 34.
Thanks. Gypsyvet 10:39, 27 August 2007 (UTC)
replies: text: Thanks for that. I've started a section on Veterinary use. We should also use the other refs. - Rod57 (talk) 12:57, 1 March 2016 (UTC)
replies: text:  Yes we should, your ref was not suitable. Please find secondary sources (if they exist) for this aspect of the topic. Alexbrn (talk) 13:02, 1 March 2016 (UTC)
thread_title:  a few citations 

message: I have been doing a little editing on the milk thistle article, so I thought I would check out silibinin as well. I think it is confusing that this article goes back and forth between discussing silibinin and silymarin. Why not put the silymarin information in a silymarin article or in milk thistle, and focus on silibinin here? --Little Flower Eagle (talk) 19:56, 26 February 2009 (UTC)
replies: text: Still a problem. Best IMO to start a new article for silymarin (~milk thistle extract). I'll do it soon if no one else does. - Rod57 (talk) 13:15, 1 March 2016 (UTC)
thread_title:  Improving this article eg split 

message: The silibinin structure shows only one of the diastereomers. Either it shoud be drawn without stereochemistry or, more preferably both diastereomers should be depicted and named. Moreover, the structure is drawn in unusual way, at least for me as chemist.  — Preceding unsigned comment added by Bidak (talk • contribs) 10:40, 8 November 2011 (UTC)
thread_title: Silibinin structure

message: The only way to reliably dose this drug is in its sodium salt form, and only those are approved; the orphan status in the EU is also interesting. Finally something to expand these entries with valid references to approvals, rather than formulations. In the pharmacology section, water solubility is discussed. Just don't delete the entry, the links and info are reliable, approval status and monographs are important. (Osterluzei (talk) 06:45, 7 March 2017 (UTC)
thread_title: Water-soluble salts

message: The link to the Mayo review is not valid.
217.233.93.120 (talk) 16:37, 3 January 2015 (UTC)
thread_title: invalid link

message: It seems to be used because it is an antioxidant - so we could perhaps explain why/how (chemically) it is an antioxidant, and perhaps say what other of its properties make it interesting for herbal/alternative medicine. eg how does it inhibit STAT3 signalling. - Rod57 (talk) 13:08, 1 March 2016 (UTC)
replies: text: What do you mean "used"? Alexbrn (talk) 14:20, 1 March 2016 (UTC)
thread_title:  Properties eg Antioxidant  

message: Medicinal Siliphos, the milk thistle extract, should not be confused with Siliphos, the water treatment chemical.
# Siliphos, the water treatment chemical, is trademarked by Kurita
# Medicinal Siliphos, the milk thistle extract, is trademarked by Indena
#These two products are NOT the same.  I suspect that the use of the same trademarked name in two different industries has caused some confusion.
Medicinal Siliphos (from Milk Thistle)
:Siliphos Info PDF
:Siliphos SILYBIN PHYTOSOME
Siliphos (water treatment chemical)
:polyphosphate
:datasheet
:MSDS
:Siliphos Info PDF
::Siliphos is a water treatment compound, a glass-like Polyphosphate containing Sodium, Calcium Magnesium and Silicate, formulated specifically for the treatment of water problems. It is shaped into unique spheres and packed in 25 kg cartons or 50 kg PE-drums.
--Above unsigned comment by someone
:Great, so this isn't the stuff in 3M water filters and every other descaling product?  I was hoping to find something about that stuff, since it's in practically every descaling water treatment cartridge. --John Moser (talk) 14:25, 19 October 2016 (UTC)
thread_title:  Siliphos Trademark Confusion