Talk:Polysorbate 80

message: It looks like someone lifted this detail from some dense, esoteric, industry report.  Can someone make this section relevant and meaningful to the casual reader?  I have no idea what the 'critical micelle concentration' is, or what concentrations of 0.012 mM and 0.006mM mean. 
Also, the list of side effects should probably be paired down, and should probably be under a more appropriate section title than 'Other Names'.  Thanks 128.148.184.11 (talk) 01:17, 17 March 2009 (UTC)
thread_title: Data, Other Names sections

message: According to the Calbiochem Detergents Manual (found here: http://www.emdbiosciences.com/SharedImages/TechnicalLiterature/1_Detbooklet_2001.pdf), the CMC of Tween 80 is 0.012 mM.  This differs by an order of magnitude from the value presented.  Upon review of the Journal of Pharmaceutical Sciences article, it seems a typo was made in entering the value into this article.
Ian Glenn 03:14, 29 April 2007 (UTC)
replies: text: Fixed.  -- Ed (Edgar181) 14:07, 23 April 2008 (UTC)
thread_title: CMC

message: The structure shown in the figure is incorrect and does not match the given molecular formula.  The oleic acid chain is missing a single -CH2- group. --24.14.237.138 (talk) 01:50, 23 April 2008 (UTC)
replies: text: I have corrected the error in the image.  Thanks for catching it.  -- Ed (Edgar181) 14:01, 23 April 2008 (UTC)
thread_title: Chemical structure

message: The opening paragraph ends with the sentence, "This synthetic compound is a viscous, water-soluble yellow liquid hydrocarbon."  But, the definition of a hydrocarbon, given at the Wikipedia page, "Hydrocarbon", is, "an organic compound consisting entirely of hydrogen and carbon."  All of the polysorbates include quite a few oxygen atoms.  They can not accurately be called hydrocarbons.  I will edit the page, removing, "hydrocarbon".
7802mark (talk) 15:40, 18 August 2016 (UTC)
thread_title: Not a Hydrocarbon

message: Studies have shown potentially serious health effects related to Tween 80. The anti HPV vaccine Gardasil contains Polysorbate 80, which is linked to infertility in mice,” noted Dee Nicholson, National Communications Director for Freedom in Canadian Health Care. [Nov 2007] Sleight of Handling: More Merck Magic Tricks With HPV Vaccine By Christopher C. Barr
A study published in December, 2005 discovered that Tween 80 can cause anaphylaxis, a sometimes fatal reaction characterized by a sharp drop in blood pressure, hives, and breathing difficulties. Researchers concluded that the severe reaction was not a typical allergic response characterized by the combination of IgE antibodies and the release of histamines; it was caused by a serious disruption that had occurred within the immune system.
In another study neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10 percent aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.” ~ PMID: 8473002.  Female lab rats injected with Tween 80 developed impaired sexual organs as well as premature development of their sexual organs. Institute of Preventive and Clinical Medicine, Limbová, Bratislava.
Previous studies by Gajdova et al. have shown that polysorbate 80 (also known as Tween 80) administered by intraperitoneal injection to neonatal female rats on days 4-7 after birth produced estrogenic effects including earlier vaginal opening, prolongation of the estrus cycle and persistent vaginal estrus. Some of these effects were evident many weeks after cessation of administration of polysorbate 80. [...] Thus, intrinsic estrogenic effects of polysorbate 80 reported following its intraperitoneal injection to neonatal 4-day-old female rats are not manifest when it is administered by oral gavage to immature 20- to 22-day-old female rats. This latter route of exposure is of more relevance to human exposure scenarios and these data are, therefore, important in assessing hazard/risk of polysorbate 80 to man. [Williams et al. - "The oral administration of Polysorbate 80 to the immature female rat does not increase uterine weight" https://www.sciencedirect.com/science/article/pii/S0378427496038635]
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I deleted the list of possible side effects, I found the (probable) source of this information, and it's a list of side effects that can be caused by drugs in general, not Tween 80 specific at all.  —Preceding unsigned comment added by 213.31.11.80 (talk) 09:21, 27 March 2009 (UTC)
thread_title:  Health effects 

message: Is someone better qualified than I able to follow up on this?  —Preceding unsigned comment added by 203.16.28.241 (talk) 09:14, 18 October 2010 (UTC)
thread_title: Possible link to Crohn's Disease?

message: 15 & 18 are duplicates.
69.72.92.222 (talk) 07:14, 29 April 2015 (UTC)
thread_title:  references 

message: The chemical structure shown for Polysorbate 80 appears to be incorrect.  Polysorbate 80 is made by polymerization of 20 equivalents of ethylene oxide with sorbitan monooleate1. The method of synthesis is summarized in Chapter 2 of Food Emulsifiers and Their Applications: Hasenhuettl, Gerard L., Hartel, Richard W. (Eds.)2.  Aside from the fact that sorbitan monooleate itself is not a pure substance, the polymerization with ethylene oxide can only modify the free hydroxyl groups.  The oleic acid ester protects one of the hydroxyl groups from modification by reaction with ethylene oxide.  Thus, there is not a synthetic basis for inclusion of a polyoxyethylene moiety adjacent to the oleate ester functionality in the structure provided.  If one assumes that the major component of sorbitan monooleate arises from the esterification of the primary hydroxyl group of 1,4-sorbitan, then the only acceptable interpretation of the structure as shown would have w=0.  Consequently, x+y+z=20 makes more sense.  
Note that there is an unfortunate error in the structure of sorbitan monooleate in the book chapter cited, which shows a secondary ester.  PubChem correctly depicts the primary ester of 1,4-sorbitan.  
1. https://pubchem.ncbi.nlm.nih.gov/compound/9920342
2. Food Emulsifiers and Their Applications: Hasenhuettl, Gerard L., Hartel, Richard W. (Eds.), 2008 pg 25-6 , https://www.springer.com/us/book/9780387752839 
JHCooke (talk) 21:56, 23 April 2018 (UTC)
thread_title:  Chemical structure of Polysorbate 80 

message: I'm just curious about one of the uses listed. It says that it's added to soaps as a surfactant. But, soap by definition is a surfactant, so why would you need to add another surfactant to it? I suppose it's not exactly black and white where something either is or isn't a surfactant, it's probably more a gradient or spectrum. 
So, conceivably they would add polysorbate-80 to give soap even more of a surfactant effect? But, I'm just speculating. I don't doubt that it's added to soaps, I've seen it myself in the ingredients. I'm just confused about the reason. Perhaps the article could expand a little on this for clarification. Even if just with a short sentence to give a bit more context. VoidHalo (talk) 15:59, 15 February 2024 (UTC)
thread_title:  Why does soap need a surfactant added to it?