Talk:Sodium–potassium pump

message: Is sodium pump not a more generally used name??
:You could add mention of sodium pump to the article. It gets 1886 hits on this search engine. There should probably be an entire section of the article that describes the various versions of the name. They list six here. —Preceding unsigned comment added by 84.51.156.172 (talk • contribs) . Signed by Brazucs
:Please add ~~~~~ to the end of your comments on discussion pages. --JWSchmidt 13:20, 14 December 2005 (UTC)
replies: text: I have always seen it written as sodium-potassium pump. --Brazucs (TALK | CONTRIBS) 05:08, 19 April 2006 (UTC)
replies: text: there are a class of sodium-specific channels essential for membrane depolarization, and the pump/channel could be confusing. Sovbeos 14:05, 25 September 2007 (UTC)
thread_title: Nomenclature

message: I find the plus signs in the title of this article distracting. I propose we instead use the much cleaner "Na,K-ATPase", which is used in several physiology textbooks, notably Boron and Boulpaep's Medical Physiology. Thoughts? --David Iberri (talk) 21:47, 20 May 2006 (UTC)
replies: text: I agree Sovbeos 14:05, 25 September 2007 (UTC)
thread_title: Name

message: Requesting fluid and electrolyte, and IV implications of the sodium potassium pump mechanism.  This seems like a lot of information with no practical application, and is therefore difficult to conceptualize.
76.19.146.152 23:36, 6 March 2007 (UTC)
thread_title:  Nursing Implications of Sodium Potassium Pump 

message: According to my Cellular Biology textbook () the sodium-potassium ATPase can also work in reverse. Under a high K+/Na+ electro-chemical gradient and depending on the concentrations of ADP and ATP inside the cell, the enzyme can phosphorylize ADP by transporting Na+ into the cell and K+ out of the cell. Seems to be an equilibrium sort of thing. If anyone can confirm, please add it to the article. Aurimas 05:26, 19 September 2007 (UTC)
thread_title:  Working in reverse? 

message: It's a serious article, and the fact that the reaction repeats itself again does not mean it is funny, or requires an exclamation mark  —Preceding unsigned comment added by 194.81.255.254 (talk) 17:17, 14 October 2007 (UTC)
thread_title: Remove exclamation mark in "Function - Mechanism"

message: The definition that I have always been told, which now seems to be wrong, is that an enzyme is biological catalyst, speeding up reactions, is this definition incomplete because this doesn't seem to be changing a reaction speed.  —Preceding unsigned comment added by Murdochious (talk • contribs) 21:27, 5 November 2007 (UTC)
replies: text: I noticed that too, in Neuroscience (Purves et. al. 2007) on p 77 it describe active transporters (of which, the sodium potassium pump is one) as plasma membrane proteins. Paskari (talk) 14:55, 1 September 2008 (UTC)
thread_title:  Why an enzyme 

message: I added a section about the critisism of the Na+/K+-ATPase. It was reverted by User:JWSchmidt
http://en.wikipedia.org/w/index.php?title=Na%2B/K%2B-ATPase&oldid=184179079
I admit that I don't have the capability to see if it's a fringe website, but it seems to me that it should be mentioned in the article, because this specific theory has been widespread in the media (UTFG); even more then if someone here could provide a link which gives a counterview to the theories of Gilbert Ling, which may eventually expose them as a fringe science. --84.226.130.70 (talk) 03:58, 14 January 2008 (UTC)
replies: text: Please suggest one or more specific peer-reviewed publications which gives a critical view of the Na+/K+-ATPase.....we can start from there. A personal website is not a good source to cite. --JWSchmidt (talk) 04:07, 14 January 2008 (UTC)
replies: text: That's true indeed. I took a look at the 3 disprovals which Ling lists on his website . (1) is a overview of different research papers (done by Ling himself) published by Blaisdell Pub. Co (2) is an article by Mullins and Brinley published in The Journal of General Physiology (3) is an article (again by Ling himself) published in The Journal of Physiology. Again I have to admit that I'm not familiar with this specific scientific community. I assume that (2) and (3) were peer reviewed, while (3) is more likely to criticise the Na+/K+-ATPase as it is from Ling himself. However the abstract of (3) does not itself directly mentions a disproval. --84.226.130.70 (talk) 05:57, 14 January 2008 (UTC)
replies: text: In (3), Ling seems particularly concerned with promoting the idea that in living cells, "anionic sites of certain protoplasmic proteins.....have more favourable adsorption energies for K+ than for Na+." He proposed that this selectivity for K+ binding to cellular proteins depends on ATP. "When ATP is removed during cell deterioration, the system goes into an alternative co-operative state, in which selectivity for K+ adsorption is lost". There is a rather extensive literature on ATP-binding proteins...are there any good publications that describe proteins shifting their K+-binding affinity in an ATP-depedent way? --JWSchmidt (talk) 22:59, 14 January 2008 (UTC)
thread_title:  Critisism to Na+/K+-ATPase 

message: The last few sentences could be cleared up a little bit:
*The pump transports 3 Na+ ions out of the cell and in exchange takes 2 K+ ions into the cell... This represents a continual net loss of ions out of the cell. As a result an opposing osmotic tendency operates to drive the water molecules out of the cells. 
This makes it seem like the cell is going to shrivel up and die. I'm assuming all this does is counteract the influx of water molecules, correct? Furthermore, why does removing 3 sodium ions and inserting 2 potassium ions force water molecules out of the cell? Paskari (talk) 15:02, 1 September 2008 (UTC)
thread_title:  Controlling of cell volume 

message: The article lists Nam Currie-Nyugen as the discoverer of a fundamental process in this article but I cannot find reference to it anywhere.  Can someone please confirm this or remove the reference? Thanks
Oniamien (talk) 03:36, 16 September 2008 (UTC)
thread_title:  Nam Currie-Nyugen 

message: There appears to be some confusion in this section. Action potentials do not, in fact, alter the relative concentrations of Na and K ion very much, and excitable cells can fire action potentials for some time after active transport is inhibited (for a good reference, see Hille (2001) Ionwoo!!!!!!!!! channels of excitable membranes). The mention of the hyperpolarisation is irrelevant in this section also, and adds to the confusion. The basic point that needs to be made is that active transport establishes and maintains a concentration gradient in the face of ongoing activity and passive leak.
---01/19/2011
I feel this description of the AP is out of place and should be removed entirely. The Na/K pump has little to do with it. Moreover, if someone does not already understand this, I believe they might find this section to be very confusing.
---  —Preceding unsigned comment added by 130.64.41.44 (talk) 20:54, 19 January 2011 (UTC)
thread_title:  Resting potential 

message: It's function as a metabolic inhibitor of the pump ought to be mentioned  —Preceding unsigned comment added by 99.255.162.25 (talk) 19:33, 17 April 2009 (UTC)
thread_title:  Nitrophenol 

message: Just found that line a bit confusing, surely it exists in some plants and microbes?
--Hellofraance (talk) 22:12, 23 January 2010 (UTC)
replies: text: It may, but I don't think it MUST, since many of these don't need sodium at all for life (some plants do and some don't). So what use a sodium pump if you don't need sodium? SBHarris 03:06, 24 January 2010 (UTC)
thread_title:  "in all animals". No Na/K pump in plants/microbes? 

message: The page seems virtually identical to Na /K -ATPase. If so the solution could be to remove the content of Na /K -ATPase and redirect Na /K -ATPase to Na+/K+-ATPase. DadaNeem (talk) 20:03, 11 December 2017 (UTC)
thread_title:  Is there any difference with [[Na /K -ATPase]]? 

message: There are major issues with the paper in reference 14 (Tian 2006) as shown here: https://pubpeer.com/publications/051A1FB51A4925891F77BCA72FC04C
It is extremely likely that some of the results in the paper were doctored, so I would not really use it as a reputable source of information.  — Preceding unsigned comment added by Gould80 (talk • contribs) 14:53, 8 February 2021 (UTC)
thread_title:  Problem with reference 14 

message: How Sodium Potassium ATPases help neurons in getting back to -70mv(Resting Potential) from -90mv. You know think about it, if a cell is Hyperpolarized then it will be at -90mv and the Sodium Potassium Pump will start working to make inside voltage equal to resting potential but if it pumps out 3 Na out then the voltage will become -93mv and kick in 2 K in so it will be -91mv. So how can we say that it helps in bringing the cell back to resting potential? Please answer me I am stucked on these question from 5-6 days. It's my humble request to you guys. 103.199.225.238 (talk) 16:01, 17 August 2022 (UTC)
thread_title:  Neurons 

message: — Assignment last updated by Bubbstar (talk) 20:11, 15 May 2023 (UTC)
thread_title: Wiki Education assignment: CHEM 378 - Biochemistry Lab - spring 2023