Talk:FOSB

message: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834048/table/T1/ 
*Ventral MSNs - mesolimbic pathway
*Dorsal MSNs - nigrostriatal pathway
Seppi333 (Insert 2¢ | Maintained) 17:30, 16 February 2015 (UTC)
thread_title: Induction in D1/D2 MSNs by stimulus and ventral/dorsal striatal region

message: G9a Seppi333 (Insert 2¢ | Maintained) 21:03, 16 February 2015 (UTC)
thread_title:  Review 

message: :Seppi333 (Insert 2¢) 15:23, 10 January 2016 (UTC)
thread_title: Antidepressant ∆FosB review

message: , do you know how to collapse the table when it is transcluded? Sizeofint (talk) 06:32, 23 March 2016 (UTC)
replies: text:  Seppi333 (Insert 2¢) 06:37, 23 March 2016 (UTC)
replies: text: Thanks! Sizeofint (talk) 06:41, 23 March 2016 (UTC)
thread_title:  Collapsed transcluded 

message: Is this paragraph linguistically correct? Especially the phrase "like drugs of abuse". 
"ΔFosB also plays an important role in regulating behavioral responses to natural rewards, such as palatable food, sex, and exercise.[6][12] Natural rewards, like drugs of abuse, induce gene expression of ΔFosB in the nucleus accumbens, and chronic acquisition of these rewards can result in a similar pathological addictive state through ΔFosB overexpression.[6][7][12] Consequently, ΔFosB is the key mechanism involved in addictions to natural rewards (i.e., behavioral addictions) as well;[6][7][12] in particular, ΔFosB in the nucleus accumbens is critical for the reinforcing effects of sexual reward.[12]"
--Igenno (talk) 18:46, 30 April 2016 (UTC)
replies: text: "Drugs of abuse" is a very vague term, but it is a term that is consistently used in some of these sources as a substitute for the term "addictive drugs".  I probably wouldn't have used it in the article if not for the sources that were cited. Seppi333 (Insert 2¢) 19:29, 30 April 2016 (UTC)
thread_title:  Role in addiction 

message: I check pages listed in :Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of :FOSB's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "Cellular basis":
From NF-κB: 
From Methylphenidate: 
From Striatum: 
From Opioid use disorder: 
From Ethanol: 
From Alternative splicing: 
From Disease theory of alcoholism: 
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 08:20, 8 January 2017 (UTC)
thread_title:  Orphaned references in [[:FOSB]] 

message: given that it's a more precise statement, wouldn't it be better to refer to FOSB as an IEG instead of a gene in the first lead sentence? I.e., writing something like "" instead of "". I normally would just be bold and change this without discussion, but I don't have a sufficient background knowledge of genetics to know whether or not this might be an incomplete, inaccurate, or otherwise incorrect description. Or more simply, I don't know what I don't know about genetics. Seppi333 (Insert 2¢) 03:56, 25 January 2019 (UTC)
replies: text: Hi Seppi.  An IEG (immediate early gene) describes when the gene is expressed and is a rather specialized topic. I also think it is important to keep the lead sentence dead simple and there should be nothing in the lead that is not discussed in more detail in the body of the article. This type of detail would be more appropriate in a new section on regulation/mechanism. There are  different type of alternative splicing, involving either truncation and/or incorporation of alternative stretches of amino acid residues.  Truncation can in principle occur anywhere (N-terminus, C-terminus, or in the interior). Boghog (talk) 05:48, 25 January 2019 (UTC)

text: In the case of human FOSB, there are 10 splice variants that have been detected which involve truncation in either the N-terminus and/or one or more of four different interior sites. Boghog (talk) 05:59, 25 January 2019 (UTC)
replies: text: Thanks for clarifying that. I suppose I'll just go ahead and mention it in the body but not the lead then. Seppi333 (Insert 2¢) 06:04, 25 January 2019 (UTC)
thread_title:  State IEG instead of gene in the intro sentence?