Talk:Mycosis fungoides

message: User : 
Bard , perche la luce del sole, in particolare gli ultravioletti UVB inducono l'apoptosi dei linfociti T tumorali della mycosis fungoides presenti nella pelle ? 
Bard di Google : 
La luce del sole, in particolare gli ultravioletti UVB, inducono l'apoptosi dei linfociti T tumorali della mycosis fungoides presenti nella pelle attraverso diversi meccanismi.
Uno dei meccanismi è l'induzione di danni al DNA dei linfociti T tumorali. Gli UVB possono danneggiare il DNA in diversi modi, tra cui la formazione di dimeri di timina, la depurinazione e la deaminazione delle basi. Questi danni al DNA possono portare all'induzione dell'apoptosi dei linfociti T tumorali.
Un altro meccanismo è l'induzione di un'infiammazione locale. Gli UVB possono attivare le cellule dendritiche della pelle, che rilasciano citochine pro-infiammatorie. Queste citochine possono indurre l'apoptosi dei linfociti T tumorali.
Infine, gli UVB possono indurre la produzione di molecole anti-cancro. Ad esempio, gli UVB possono indurre la produzione di interleuchina-22, che è una molecola che può uccidere i linfociti T tumorali.
I meccanismi specifici coinvolti nell'apoptosi dei linfociti T tumorali della mycosis fungoides indotta dai raggi UVB non sono ancora del tutto chiari. Tuttavia, è probabile che diversi meccanismi agiscano in sinergia per indurre questo effetto.
I raggi UVB sono stati utilizzati per il trattamento della mycosis fungoides per molti anni. Sono un trattamento efficace per la malattia in stadio iniziale, ma possono causare effetti collaterali, come scottature solari e iperpigmentazione.
In futuro, è probabile che gli studi sulle basi molecolari dell'apoptosi dei linfociti T tumorali della mycosis fungoides indotta dai raggi UVB portino allo sviluppo di nuovi trattamenti più efficaci e con meno effetti collaterali.
User : 
Bravo. 
Spiegami un altra cosa sempre in relazione alla precedente risposta. 
Perché l'assunzione di olio di cartamo molto ricco di omega 6 favorisce la remissione delle macchie di micosi fungoides cioè la morte delle cellule linfociti T tumorali,   specie se ci prendi subito insieme il sole. Le due cose interagiscono ? 
Bard di Google: 
L'olio di cartamo è ricco di acidi grassi omega-6, che sono un tipo di grassi insaturi. Gli acidi grassi omega-6 hanno dimostrato di avere un effetto anti-infiammatorio e anti-tumorale.
Nella mycosis fungoides, i linfociti T tumorali si accumulano nella pelle e causano infiammazione. L'infiammazione può contribuire alla crescita e alla diffusione delle cellule tumorali.
L'assunzione di olio di cartamo può aiutare a ridurre l'infiammazione nella mycosis fungoides. Questo può contribuire alla morte delle cellule linfociti T tumorali e alla remissione della malattia.
L'esposizione ai raggi UVB può anche aiutare a ridurre l'infiammazione nella mycosis fungoides. Inoltre, i raggi UVB possono indurre la produzione di molecole anti-cancro, che possono contribuire alla morte delle cellule linfociti T tumorali.
L'olio di cartamo e i raggi UVB possono quindi interagire per aumentare l'effetto anti-infiammatorio e anti-tumorale.
Ecco alcuni meccanismi specifici attraverso i quali l'olio di cartamo e i raggi UVB possono interagire per favorire la remissione della mycosis fungoides:
Gli acidi grassi omega-6 possono aiutare a proteggere le cellule della pelle dai danni dei raggi UVB.
Gli acidi grassi omega-6 possono aiutare a stimolare la produzione di molecole anti-infiammatorie, come l'interleuchina-10.
I raggi UVB possono aiutare a promuovere il metabolismo degli acidi grassi omega-6, che può aumentare il loro effetto anti-infiammatorio.
È importante notare che questi meccanismi non sono ancora stati completamente chiariti. Tuttavia, gli studi suggeriscono che l'olio di cartamo e i raggi UVB possono avere un effetto sinergico per migliorare la prognosi della mycosis fungoides.
È importante consultare un medico prima di iniziare a utilizzare l'olio di cartamo per la mycosis fungoides.  — Preceding unsigned comment added by 151.38.103.242 (talk) 21:12, 2 September 2023 (UTC)

message: Anyone can add how fatal this is? Kortsleting (talk) 13:17, 16 February 2016 (UTC)
replies: text: Somebody did that in January 2018. Thanks to this editor! Linuxo (talk) 08:14, 2 June 2018 (UTC)
thread_title: note

message: Pautrier's microabscesses redirects here (eg from Sézary disease) but it does not seem to be even mentioned. - Rod57 (talk) 03:27, 30 November 2017 (UTC)
replies: text: I've edited the diagnosis chapter with criteria on the skin biopsy. There's a little part about "Pautrier microabcesses" inside. Hope it helps. Linuxo (talk) 08:12, 2 June 2018 (UTC)
thread_title:  Pautrier's microabscesses redirects here 

message: I cut the following as it didnt seem specific to MF (and had no source/ref).
- Rod57 (talk) 04:15, 30 November 2017 (UTC)
thread_title:  Bland text cut from Treatments section 

message: Hello fellow Wikipedians,
I have just modified one external link on Mycosis fungoides. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://archive.is/20121212102832/http://infohawk.uiowa.edu/F?func=direct&doc_number=000636854&l_base=uiowa to http://infohawk.uiowa.edu/F?func=direct&doc_number=000636854&l_base=uiowa
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 00:02, 10 February 2018 (UTC)
thread_title:  External links modified (February 2018) 

message: Your proposals are sound. Please feel free to BE BOLD and implement them in the article. And thank you.--Quisqualis (talk) 16:37, 7 December 2020 (UTC)
thread_title:  December 2020: Please be bold and make your proposed edits 

message: We propose to introduce the relationship between SS and MF earlier to improve clarity: "People with mycosis fungoides can also develop Sézary syndrome (SS). SS is a rare leukemic variant where cancerous lymphocytes found in mycosis fungoides are also found in the blood (leukemic disease). It is referred to as leukemic mycosis fungoides, Sézary syndrome preceded by mycosis fungoides, or secondary mycosis fungoides. However, not all forms of Sézary syndrome are an advanced form of mycosis fungoides." Tnarang
::Thank you for sharing this suggestion. Should we include a wikilink for Sézary syndrome?JenOttawa (talk) 00:48, 23 November 2021 (UTC)
thread_title: Improvement 1

message: We propose changing the following in the Signs and Symptoms section. Deleting the first sentence on Pruritus and adding the following sentence just previous to the discussion of Sezary Symptoms. "Itching (Pruritus) is the most commonly reported symptom of people experiencing Mycosis Fungoides with up to 88% of people reporting varying intensities of pruritus that typically  worsens as the disease progresses. Those that experience intense pruritus commonly indicate that it negatively affects their quality of life emotionally, functionally and physically. Oheid25 (talk) 21:22, 17 November 2021 (UTC)
replies: text: Looks good. Super minor edit- remove the space between the citation and the punctuation. JenOttawa (talk) 01:00, 23 November 2021 (UTC)
thread_title: Improvement 2

message: We propose the following change after the second sentence in the Signs and Symptoms section "The progression of MF is initially slower and later accelerates. The overall average disease progresssion in people with mycosis fungoides is approximately 12 years. There is no controversy in this article."  Blairrachel123  comment added 20:18, 16 November 2021 (UTC)
replies: text: Feedback: Try to remove the use of "patients"- i.e., overall average disease progresssion in people with mycosis fungoides is approx...". If there are page #s from you text book about where you found this information please include as well. Great edit! JenOttawa (talk) 01:02, 23 November 2021 (UTC)
thread_title: Improvement 3

message: We propose the following change after the word "buttocks" in the Signs & Symptoms section: These lesions can start as insignificant patches and may remain undiagnosed for up to a decade . Hypopigmented (when the skin is lighter than normal) lesions are less common but can be found in children, adolescents and/or dark-skinned individuals .
:::Feedback: This edit looks good. Can you try to add the citation using the 'cite tool' as we practiced in class in your sandbox? Please reach out if you are having trouble. The talk page is not set up for the visual editor tool so it is normal that some people had trouble here.I am happy to help in our final session next week. JenOttawa (talk) 01:04, 23 November 2021 (UTC)
thread_title: Improvement 4

message: We propose adding additional information on treatment of relapsed or refractory MF, replacing the last sentence of the Treatment section with "Systemic treatments of mycosis fungoides often lead to resistance; as such, additional treatment options are often necessary in advanced disease. Mogamulizumab is a CCR4 monoclonal antibody which has been shown to improve progression-free survival. It was approved by the US FDA in 2018 for use in people with relapsed or refractory mycosis fungoides or Sézary disease." SGL14EH (talk) 20:55, 17 November 2021 (UTC)
replies: text: Feedback: Please note that the citation goes immediately after the punctuation and not before. Just a picky edit, your improvement looks great.JenOttawa (talk) 01:06, 23 November 2021 (UTC)
thread_title: Improvement 5

message: We propose adding the following information to the beginning of the "Treatments" section: "The most commonly recommended first-line treatment for mycosis fungoides is psoralen plus ultraviolet A (PUVA therapy). PUVA is a photochemotherapy that involves topical or oral administration of the photosensitizing drug psoralen followed by skin exposure to ultraviolet radiation. Although other treatments have been used in combination with PUVA, there is a lack of evidence to support that these combination therapies are effective. ". We also propose citing "interferons" as an example of biological treatments rather than a systemic treatment. SGL14 RS (talk) 02:24, 18 November 2021 (UTC)
replies: text: Feedback: Are there any wikilinks that would be appropriate to add here? Looks good!JenOttawa (talk) 01:08, 23 November 2021 (UTC)
thread_title: Improvement 6

message: We propose adding the following information to the "Treatments" section: "Treatment for adults and children with Mycosis Fungoides often differs because of the safety profiles of modalities. Narrowband UV-B is commonly considered for children, as opposed to Psoralen with UV-A, mechlorethamine hydrochloride, and oral bexarotene, which is often used in adults" ." Nanjij (talk) 13:50, 19 November 2021 (UTC)
replies: text: Great work preparing these. ould UV-B be wikilinked? I don't think you need to use capitals on on the drug names or the condition name when it is in a sentence like this. Nice systematic review! Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:11, 23 November 2021 (UTC)
thread_title: Improvement 7

message: We propose adding the following information to the "Prognosis" section: "In children, a significant delay in correct diagnosis from the onset of lesions is associated with poorer outcomes and poorer overall survival rates ."Nqmed (talk) 13:49, 19 November 2021 (UTC)
replies: text: Good use of this systematic review. This edit looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:12, 23 November 2021 (UTC)
thread_title: Improvement 8

message: We propose adding a sentence directly prior to “The patch stage is defined by flat, reddish patches of varying sizes that may have a wrinkled…” in the "Signs and Symptoms" section: The patch stage can be subdivided into stage IA and IB, defined by the amount of surface area the patches cover (Stage IA, covering less than 10% of the skin’s surface area and Stage IB greater than 10% of the skin’s surface area).
::Looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:13, 23 November 2021 (UTC)
thread_title: Improvement 9

message: We propose adding the following sentence "As the patches spread, they can evolve into palpable plaques, known as the plaque stage" after the sentence " they can also look yellowish in people with darker skin" to the "Signs and Symptoms" section.
:::This looks good. Super minor comment: note your placement of the citation (move it to immediately after the punctuation, no space).JenOttawa (talk) 01:14, 23 November 2021 (UTC)
thread_title: Improvement 10

message: There should be a new subheader for “Histological Features” in the “Diagnosis” section, and the disease criteria should be reworded as follows: 
 
Histology Features
The criteria for the disease are established on the skin biopsy by the presence of the following[10]: 
The superficial papillary dermis is infiltrated by a band of cancer cells (Vaidya & Badri, 2021)
Epidermotropism during the early stages, characterized by dense infiltrates of cancer cells clustered in the epidermis (Vaidya & Badri, 2021)
Presence of atypical T-cells with cerebriform nuclei in the dermal and epidermal infiltrates
Pautrier's microabcesses, aggregates of four or more atypical lymphocytes arranged in the epidermis.[11] Pautrier microabcesses are characteristic of mycosis fungoides but are generally absent. Whynoteditawiki (talk) 23:36, 18 November 2021 (UTC)
replies: text: Thanks for this suggestion. It looks good. Please practice inserting your references with the citation tool. I realize it is different here on the talk page without the visual editor. If you need help while editing live next week please don't hesitate to ask!JenOttawa (talk) 01:22, 23 November 2021 (UTC)
thread_title: Improvement 12

message: This statement will be added at the end of the “Histology” subsection in the “Diagnosis” section.
“Early phases of MF are difficult to diagnose because its histopathological hallmark features (i.e. Pautrier's microabscesses and epidermotropism) are often absent in early MF. Furthermore, long periods of treatment before a biopsy is performed can cause the specimen to have “non-specific” histopathological features, making it difficult to distinguish from other inflammatory dermatoses.” Kim779 (talk) 04:52, 20 November 2021 (UTC)
replies: text: Looks great. Are there any terms that you can add wikilinks to here? JenOttawa (talk) 01:23, 23 November 2021 (UTC)
thread_title: Improvement 13

message: We propose that this statement should be added to “Diagnosis” section under the paragraph regarding Pautrier’s microabscesses:
“T-lymphocyte clonality testing can be undertaken to identify whether cancer cells originateed from a single mutated cell. This can be done through special stains (e.g., immunohistochemistry) and genetic testing (e.g., polymerase chain reaction)." 99kiru12 (talk) 14:30, 18 November 2021 (UTC)
replies: text: Good work preparing this.JenOttawa (talk) 01:24, 23 November 2021 (UTC)
thread_title: Improvement 14

message: This paragraph should be added to the “Staging” section: 
The histopathology of Mycosis Fungoides can be divided into three stages: The Patch stage, The Plaque stage and The Tumour stage . In early patch stages it can be difficult to diagnose, however as patches become more established an atypical lymphocytic proliferation (lymphocytic infiltrate) can be seen. This stage also can mimic other disorders such as eczema making further testing necessary to make a diagnosis. In the plaque stage, the epidermis shows an overgrowth (acanthosis) in addition to more cell movement towards the epidermis (epidermotropism). In the tumour stage, tumours will begin to form making a denser infiltrate there will be a diminished number of T lymphocytes, which are an essential part of our immune system. Farzanansari10 (talk) 14:07, 18 November 2021 (UTC)
replies: text: Feedback: This looks good to me. I don't think that capitals are necessary on the names of the stages: The Patch stage, The Plaque stage and The Tumour stage.  Are there are any wikilinks that can be added to help define text and link to other articles. JenOttawa (talk) 14:37, 23 November 2021 (UTC)
thread_title: Improvement 15

message: Current sentence under “Diagnosis”: Several biopsies are recommended, to be more certain of the diagnosis.
Change: A biopsy, or several biopsies, is insufficient to diagnose mycosis fungiodes. Instead, a complete diagnosis requires a combination of clinical and histological study.
:::Feedback: This looks good. Can you please share the citation that you propose to use to support this sentence?JenOttawa (talk) 14:39, 23 November 2021 (UTC)
thread_title: Improvement 16

message: The following should be added under the "Treatment" subheading: 
Treatments are often used in combination and depend on the staging of mycosis fungoides. Treatment of stage I and stage II often includes radiation therapy, immunotherapy, topical chemotherapy, systemic chemotherapy or targeted therapy. Stage III and stage IV mycosis fungoides offer the  addition of extracorporeal photochemotherapy. Lastly recurrent mycosis fungoides can also be treated with high-dose chemotherapy with a stem cell transplant as well as all treatment options listed above. Weersinkedit (talk) 17:06, 18 November 2021 (UTC)
replies: text: Feedback: Your citation looks good. Please watch the use of capitals (keep it consistent). We usually do not use capitals on medical terms in the middle of the sentence (e.g.- chemotherapy), you can link it without the capital. Only one more picky suggestion- please ensure that the citation is placed behind the punctuation like this.1 JenOttawa (talk) 14:42, 23 November 2021 (UTC)
thread_title: Improvement 17

message: I wish to add the following survival rates for the different stages of this disease
Original:
Most patients with Mycosis Fungoides have early-stage disease (Stage IA-IIA) at the time of their initial diagnosis.[13] These patients with early stage disease that is primarily confined to the skin have a favorable prognosis.[13] Patients with advanced stage (Stage IIB-IVB) are often refractory to treatment and have an unfavorable prognosis.[13] Treatment of patients with advanced stage disease is designed to reduce tumor burden, delay disease progression, and preserve quality of life.[13]
Edits:
Most patients with Mycosis Fungoides have early-stage disease (Stage IA-IIA) at the time of their initial diagnosis.[13] These patients with early stage disease that is primarily confined to the skin have a favorable prognosis, with a 5-year survival rate of 85.8% for Stage IB.[13, 14] Patients with advanced stage (Stage IIB-IVB) are often refractory to treatment and have an unfavorable prognosis, with a 5-year survival rate of 62.2% for Stage IIB and as low as 23.3% in Stage IVB, the further stage.[13,14] Treatment of patients with advanced stage disease is designed to reduce tumor burden, delay disease progression, and preserve quality of life.[13]
Reference: 
[14] Mourad A, Gniadecki R. Overall Survival in Mycosis Fungoides: A Systematic Review and Meta-Analysis. J Invest Dermatol. 2020 Feb;140(2):495-497.e5. doi: 10.1016/j.jid.2019.07.712. Epub 2019 Aug 26. PMID: 31465745. Dannythekey (talk) 05:15, 19 November 2021 (UTC)
replies: text: Feedback: On Wikipedia we try to avoid using "patients"- "Most people with mycosis fungoides have early-stage..." and "for people with advanced stage disease", for example. Please also ensure that you are prepared to add your citations with the 'cite tool' on Wikipedia as we learned in class. It is harder to practice this on the talk page as it does not use the visual editor (as you likely noticed). Please practice in your sandbox and reach out next week if you need help making the edit live on Wikipedia.JenOttawa (talk) 14:50, 23 November 2021 (UTC)
thread_title: Improvement 18

message: We propose combining the first two sentences of the Epidemiology section about disease incidence/frequency by age and adding an additional sentence about disease pattern by sex and ethnic group, as follows: “It is rare for Mycosis Fungoides to appear before age 20; the average age of onset is between 45 and 55 years of age for people with patch and plaque disease only, but is over 60 for people who present with tumours, erythroderma (red skin) or a leukemic form (the Sézary syndrome). Mycosis Fungoides is more common in males than in females with the majority of people living with the disease being of Caucasian ethnicity.” --Jzucker14 (talk) 00:35, 20 November 2021 (UTC)
replies: text: Feedback: This looks good. Good use of your reference. No need to capitolize mycosis fungosis mid sentence. I am not certain if caucasian needs to be capitolized. JenOttawa (talk) 14:52, 23 November 2021 (UTC)
thread_title: Improvement 19

message: I will be making the following edit:
Original:
“The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics.”
Edits:
“The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics. This contrasts to a reported increase in incidence in the Netherlands between 2000 and 2020, suggesting regional trends.[21]
Reference: 
Ottevanger, R. O. S. A. N. N. E., de Bruin, D. T., Willemze, R., Jansen, P. M., Bekkenk, M. W., de Haas, E. R. M., ... & Quint, K. D. (2021). Incidence of mycosis fungoides and Sézary syndrome in the Netherlands between 2000 and 2020. The British journal of dermatology, 185(2), 434.  ImranMSyed (talk • contribs) 15:13, 19 November 2021 (UTC)
replies: text: Feedback: Please practice adding your citation using the citation tool as we did in class. You can practice in your sandbox and reach out in class if you need further assistance. Here is an example of what it should look like: “The incidence of mycosis fungoides was seen to be increasing till the year 2000 in the United States,[20] thought to be due to improvements in diagnostics. This contrasts to a reported increase in incidence in the Netherlands between 2000 and 2020, suggesting regional trends. JenOttawa (talk) 14:56, 23 November 2021 (UTC)
thread_title: Improvement 20

message: We propose to insert the following content into the "Prognosis" section:
“In mycosis fungoides cases where affected lymphocytes grow with disease progression (large cell transformation), presence of the transmembrane receptor CD30 in affected cells is associated with improved survival.”
Endothelium (talk) 23:22, 19 November 2021 (UTC)
replies: text: Feedback: This looks good. Are there any wikilinks that would be appropriate to add here? JenOttawa (talk) 14:57, 23 November 2021 (UTC)
thread_title: Improvement 21

message: We propose the following changes for the "Cause" section:
Mycosis fungoides is caused by a proliferation of malignant T cells which have a preference for localizing to the epidermis (outermost layer of skin). It is hypothesized that genetic and cellular signalling abnormalities are involved in the malignancy and increased proliferation of the cancerous T-cells. ”  Llokdew (talk) 01:33, 20 November 2021 (UTC)
replies: text: Feedback: This looks good. It is quite technical, however, I realize it is hard to summarize. A few wikilinks (if not already linked earlier in the article) may help. Very minor edit is also to ensure that the citation is located immediately after the punctuation (no space).JenOttawa (talk) 14:59, 23 November 2021 (UTC)
thread_title: Improvement 22