Talk:Endocannabinoid system

message: Sigh.
Would anyone be willing to make a picture for this article?  I am downright confused at the legal mumbo-jumbo just to utilize an illustrative picture from Nature or Science.   If would anyone would be willing to do this, please write a message here so we can swap emails.  I can send you some nice (copyrighted, unfortunately) photographs plus some nifty (least I think so!) additions I'd like to see. - Winter Light
:I agree that this articles needs images (along with a lot of other needed work). I know that legal issues surrounding image use are daunting, so let me know your ideas, and I'll see if I can help. If you become a registered user on wikipedia, we can talk more about things and possibly exchange emails through that method. (I do not advise posting your email on sites like this. I've heard it can lead to a ton of spam mail.) If you have more questions about wikipedia and its policies in general, talk to me on my user talk page (click on the brown symbol after my name. It means "talk") --Tea with toast (話) 05:29, 24 July 2011 (UTC)
thread_title:  Help? 

message: Ok, does anyone actually want to talk about the article?   The intro is all wrong.  You can't release neuromodulators.    That doesn't even exist.  What was wrong with the original version that its been replaced with faux scientific terms?  
Winter Light (talk) 11:26, 22 October 2008 (UTC)
replies: text: what's wrong with it?  more specifically, i mean.  Why can't you release a neuromodulator (altho i agree the phrasing is a little awkward)?  are there any other 'faux scientific terms' you have issue with?  IMHO, the old intro was bad because it just described a bunch of things that were maybe regulated by the ECS without actually describing what the ECS consists of. Roadnottaken (talk) 21:23, 22 October 2008 (UTC)
thread_title:  The intro is all wrong. 

message: In summary, these pages on endocannabinoid receptors were not lacking attention before my edits, but had rather received too much attention from people who just did not know what they were talking about. I have simplified, clarified, and expounded where appropriate with the intention of creating a more cohesive and through product. The extent of these edits are subtle, but were based on eight research pages that I read dealing with the topics I addressed.  — Preceding unsigned comment added by Wyliea (talk • contribs) 01:42, 7 December 2011 (UTC)
thread_title: 12/6/2011 Edits

message: Cannabis constituents are really very interesting and laid the foundation for an entirely new receptor class. I am not sure though if the original papers here really imply that smoked or inhaled cannabis is more beneficial. Endogenous and exogenous agonists had this effect (to control spasticity and mp in mice). Also, the very early, medicinal use of cannabis and products thereof, as far as historical records go, was usually not in the smoked form. So we need to change this also to be accurate. (Osterluzei (talk) 02:42, 1 July 2012 (UTC)
thread_title:  Multiple Sclerosis references

message: deleted a faux-science "history and background" section that was not supported by any fact and was nonsense
as a biochemistry undergrad with only one course in neuroscience, I find the rest of this article to be a wonderful introduction to the subject, not too technical in the slightest.  — Preceding unsigned comment added by 108.0.151.17 (talk) 08:34, 17 July 2012 (UTC)
thread_title: faux-science "history and background" section

message: The lead paragraph is technical.  I do not want to remove any of the technical content from this article.  But I would like to have a short paragraph at the beginning to help the non-technical reader.
As a start to creating an agreed paragraph: Is it accurate to say that endocannabinoids are hormones?  — Preceding unsigned comment added by 31.126.253.20 (talk) 22:24, 28 August 2012 (UTC)
replies: text: I agree with you that the lead paragraph is too technical. I don't know if endocannabinoids are hormones, but please feel free to add a short paragraph at the beginning - as long as you also insert references. Lova Falk talk 11:31, 30 August 2012 (UTC)
thread_title:  2 part lead paragraph? 

message: Can someone please create a section with information regarding the apoptotic properties of the endocannabinoid system?  — Preceding unsigned comment added by 76.115.136.55 (talk) 08:20, 1 August 2013 (UTC)
thread_title:  Apoptotic Properties 

message: Just some notes to help in rewriting for WP's lay audience, per article tag.
:PMC 3442177" the endogenous cannabinoid system was discovered two decades ago."
:"Cannabis-based medications exert their effects mainly through the activation of cannabinoid receptors (CB1 and CB2)" 
:"It was only in 1964 that (-)-trans-delta-9-tetrahydrocannabinol (THC, dronabinol), the principal active ingredient of cannabis, was stereochemically defined (8). This, followed by the discovery of the body’s own cannabinoid system with specific receptors and endogenous ligands, marked the beginning of intensive research into the function of the endocannabinoid system and the clinical relevance of cannabis-based medications"
:"To date, two endogenous cannabinoid receptors have been identified." (2012) [See this section for details on CB1 and CB2]   petrarchan47คุก 03:30, 17 October 2015 (UTC)
thread_title: Need for non-technical presentation

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thread_title:  External links modified 

message: I found the first paragraph understandable. I have a bachelor's degree in the arts and two years of post-graduate education. But I cannot understand a single paragraph that comes after, and hardly a single sentence. Could someone who understands this subject please rewrite it for a non-expert to be able to gain some information? I don't know how to trigger the "too technical" Wikipedia banner, but I truly believe it applies here.  — Preceding unsigned comment added by Frimmin (talk • contribs) 17:23, 23 April 2020 (UTC)
replies: text: I will add the banner. I'd try to simplify it myself but I haven't the foggiest idea what the article is about. Edward-Woodrow (talk) 23:00, 16 November 2023 (UTC)
thread_title:  Translate into English? 

message: I'm noting this here because I'm not sure how this should be rewritten. In the third paragraph of the "expression of receptors" section it states that endocannabinoids bind to "certain orphan receptors" including GPR18, GPR55, and GPR119. However, a study from 2007 referenced on all three pages for these receptors indicates that endocannabinoids bind these receptors, so they're not really "orphan receptors" anymore (in fact the GPR18 page states that the three named receptors were previously orphan receptors). Lumberjane Lilly (talk) 19:53, 8 January 2021 (UTC)
thread_title:  "Expression of receptors" section 

message: I don't expect a definition in this article, but could someone create a link that would help define what is meant by the "cloning" of the two receptor types? I'm referring to the text in the second paragraph of the opening. BrianWilloughby (talk) 01:05, 15 October 2021 (UTC)
thread_title:  What does it mean to "clone" a receptor?