Talk:Pigmented villonodular synovitis

message: You should certainly add the article. You may want to categorize it with other joint conditions. - Cyborg Ninja 10:18, 27 July 2007 (UTC)
replies: text: I'm going to do more work on it then add it to mainspace. DarthGriz98 04:08, 30 July 2007 (UTC)
thread_title: July

message: Worst case is not joint replacement.  It is amputation.  I know that first hand.  PVNS survivor.  — Preceding unsigned comment added by 2602:301:77E2:C6F0:E950:8ECA:A225:914C (talk) 03:40, 2 May 2017 (UTC)
thread_title:  worst case  

message: NOTE: I am proposing this edit for FleishmanHillard on behalf of Daiichi Sankyo. I am a paid editor and am aware of the COI guidelines. 
I am submitting this edit request to bring your attention to the fact that the World Health Organization reclassified pigmented villonodular synovitis (PVNS) and giant-cell tumor of the tendon sheath (GCT-TS) to “tenosynovial giant cell tumor” or “TGCT” in 2013 in its 4th edition of WHO Classification of Tumours of Soft Tissue and Bone  (paid subscription required) to encompass a family of lesions in the soft tissue surrounding large & small joints, which all share a common pathogenesis. 
As you know, this is a rare disease with very limited online resources, and the scientific and medical community are continually learning more about the condition. There are several resources containing information about TGCT, and a few are provided below, which should not be considered all-inclusive. Publications about TGCT have been posted by: 
* National Institutes of Health (The Patient Perspective on the Impact of Tenosynovial Giant Cell Tumors on Daily Living: Crowdsourcing Study on Physical Function and Quality of Life ; Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis) . 
* Clinicaltrials.gov, where you can see that TGCT trials  include both PVNS trials  and giant cell tumor of the tendon sheath trials .
We gather it is your objective to ensure the community has as much accurate and up-to-date information possible. Toward that end, we’re requesting that the existing PVNS page be updated to include “TGCT” as an overarching name for the condition as adopted by the World Health Organization and the National Organization for Rare Disorders. 
Thank you for your consideration. Jon Gray (talk) 22:55, 31 October 2018 (UTC)
thread_title:  Edit Request 

message: # If your request is to change the article's title, those requests should be submitted using  specifically as a controversial move request process requiring discussion amongst the wider community. More information may be found at requested moves. 
# If your request is to change the instance of the word in certain areas of the article, please propose verbatim the changes here on the talk page. 
If choice number two above is your intention, kindly change the  template's answer parameter to read from  to 
Regards,  Spintendo  07:53, 1 November 2018 (UTC)
thread_title: Reply 01-NOV-2018

message: NOTE: I am proposing this edit for FleishmanHillard on behalf of Daiichi Sankyo. I am a paid editor and am aware of the COI guidelines. 
 As a follow up to your request for clarification, our request is submitted with the intention of adding a passage to the existing first sentence of this page which introduces diffuse-type tenosynovial giant cell tumor as an alternate name for PVNS. Requested verbatim addition (bolded) and sourcing follow:
* Pigmented villonodular synovitis (PVNS), also known as diffuse-type tenosynovial giant cell tumor or TGCTis a joint disease characterized by inflammation and overgrowth of the joint lining.
Thank you for your consideration. Jon Gray (talk) 16:05, 6 December 2018 (UTC)
thread_title:  Clarification on Edit Request 

message: * In technical articles that use uncommon terms, a higher-than-usual link density in the lead section may be necessary. But the function of links is to clarify, not emphasize. Guidance suggests in those cases that the wording should provide an informal explanation in the lead first, thereby avoiding the use of too many technical terms until later in the article.
* See also Wikipedia:Make technical articles understandable and point 7 of 
Regards,  Spintendo  02:05, 7 December 2018 (UTC)
thread_title: Reply 06-DEC-2018

message: NOTE: I am seeking clarification for FleishmanHillard on behalf of Daiichi Sankyo. I am a paid editor and am aware of the COI guidelines. 
 Thanks for your response. To clarify, are you/the guideline suggesting that introducing the alternate term for the condition may be better suited later in the article? If so, we're happy to submit an alternate recommendation for the edit to abide by that guideline. Please let me know your thoughts. Jon Gray (talk) 22:18, 7 December 2018 (UTC)
thread_title: Further Clarification Requested re: Reply 06-DEC-2018

message: *Your request is to associate the condition specified in one Wikipedia article with another condition specified in another Wikipedia article with the qualification that these two conditions are identical. 
*The desired outcome should be not having two separate articles describe the same condition. 
*To remedy this, the best course of action would be to merge the two articles into one, a process which requires input from the wider community in order to be granted. If you concur, please make your request at selective merge requests. 
Please feel free to contact Wikipedia:WikiProject Merge if you require additional assistance with your request. 
Regards,  Spintendo  00:45, 29 January 2019 (UTC)
thread_title: Reply 28-JAN-2019

message: NOTE: I am proposing this discussion for FleishmanHillard on behalf of Daiichi Sankyo. I am a paid editor and am aware of the COI guidelines.
At the recommendation of a conflict of interest editor who I’d previously contacted about adding  (TGCT) as a synonym for diffuse-type pigmented villonodular synovitis (PVNS), I am opening this merger discussion to ask the community for guidance on how to go about updating the language describing tenosynovial giant cell tumor (TGCT) on Wikipedia to conform with new disease definitions announced by the World Health Organization. 
Currently, there is not a stand-alone TGCT page. It instead redirects to the giant-cell tumor of the tendon sheath (GCT-TS) page, which does not include TGCT terminology. This would suggest TGCT is solely a synonym for GCT-TS, which is incorrect. According to literature, TGCT is also closely related (and some say interchangeable) with pigmented villonodular synovitis (PVNS). 
We’ve listed a several sources (and related quotes) below for reference with the discussion. As seen within these quotes, the term “tenosynovial giant cell tumor” or “TGCT” is used by leading health organizations and in connection with mentions of both pigmented villonodular synovitis (PVNS) and giant-cell tumor of the tendon sheath (GCT-TS):
* From the World Health Organization: Tenosynovial giant cell tumour, localized type:
**“The term “giant cell tumour of tendon sheath” encompasses a family of lesions most often arising from the synovium of joints, bursae and tendon sheaths. These tumours are usually divided according to their site (intra- or extra-articular) and growth pattern (localized or diffuse) into two main subtypes, which differ in their clinical features and biological behaviour, but appear to share a common pathogenesis. This family of lesions includes the localized giant cell tumour of tendon sheath/tenosynovial giant cell tumour, and the more diffuse and destructive variant called diffuse-type giant cell tumour/pigmented villonodular synovitis.”
***“Tenosynovial giant cell tumour, diffuse type. Synonyms: Diffuse-type giant cell tumour; pigmented villonodular synovitis; pigmented villonodular tenosynovitis.”
* From Lucas in Archives of Pathology & Laboratory Medicine:
**“Tenosynovial giant cell tumors are a group of generally benign intra-articular and soft tissue tumors with common histologic features. They can be roughly divided into localized and diffuse types. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse-type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive.”
* From Rateb et al. in International Journal of Surgical Case Reports:
** “Tenosynovial giant cell tumors (TGCTs), also known as pigmented villonodular synovitis, are benign soft tissue tumors that arise from the synovium of the joints, bursae and tendon sheath. These tumors are classified into two forms: localized and diffuse (Fig. 1). Diffuse-type giant cell tumor is an extra-articular form of pigmented villonodular synovitis.” 
* From Clinicaltrials.gov:
** TGCT trials  include both PVNS trials  and giant cell tumor of the tendon sheath trials. 
 
Though I understand that PVNS and GCT-TS are not synonyms, (and thus may not be candidates for a direct merge together), the two conditions are closely connected to TGCT. Because the term “tenosynovial giant cell tumor” or “TGCT” is used by medical professionals and patients, we believe it’s important the condition be accurately defined on Wikipedia. By initiating this discussion, our hope is to gain consensus among the community for how to go about doing so.
Thank you for your consideration. Jon Gray (talk) 01:25, 12 April 2019 (UTC)
replies: text: Perhaps the best way forward might be to merge both Giant-cell tumor of the tendon sheath and Pigmented villonodular synovitis to the broadest title, Tenosynovial giant cell tumor. There, both the articular (PVNS) and extra-articular (GCT-TS) forms can be discussed, with their local and diffuse forms. This might be best because of the overlapping use of nomenclature amongst these closely related tumors. Klbrain (talk) 13:21, 21 June 2020 (UTC)
thread_title: Merger Discussion

message: Hi all, posting here on behalf of Daiichi Sankyo, which is a client of my employer, Porter Novelli.
Previously, there has been some initial discussion about merging Pigmented villonodular synovitis (PVNS) and Giant-cell tumor of the tendon sheath (GCT-TS) into the same article. This is because the medical consensus is that PVNS and GCT-TS are variations of the same condition: Tenosynovial giant cell tumor (TGCT). I would now like to propose that both of these articles be merged into a new tenosynovial giant cell tumor article, which I have drafted here. This new article draft includes content from both the PVNS and GCT-TS articles (specific diffs are linked on the draft’s talk page), as well as additional research, including context on the relationship between PVNS and GCT-TS (also called localized TGCT and diffuse TGCT, respectively) and the ways in which they differ. I’ve done my best to align the draft with WP:MOSMED and provide rigorous, high-quality medical sources throughout.
 Pinging you since you've been involved in these discussions before.
Due to my conflict of interest, I will not be editing any mainspace articles related to these topics directly. I appreciate any help or feedback regarding this article merge. Thank you! Mary Gaulke (talk) 20:18, 16 July 2020 (UTC)
replies: text: that's a great draft of the combined article, with extended content too. Thank you also for your COI declaration; my view is that the COI hasn't significantly affected the objectivity of the draft. Your current proposal is also consistent with my previous proposal, and given that that there are no objections to this, I think that it would be reasonable to do this. As Tenosynovial giant cell tumor already exists I'm somewhat torn between suggesting a technical move (from draft space) and a three-way merge. I'll give the latter a go, but don't mind if an administrator would prefer the former (although the technical move would not formally attribute earlier work on the Giant-cell tumor of the tendon sheath and Pigmented villonodular synovitis articles). Klbrain (talk) 07:28, 6 August 2020 (UTC)
replies: text:  Klbrain (talk) 07:37, 6 August 2020 (UTC)
replies: text: Thank you so much for your help! Mary Gaulke (talk) 13:42, 6 August 2020 (UTC)
thread_title:  updated merge proposal: Tenosynovial giant cell tumor