Talk:Influenza research

message: Can a cocktail of HA1..HA16 and N1..N9 be used directly as a flu vaccine with a promoter?
I've just read in this article that:
:"Another technique is use of cell cultures to grow vaccine strains; such as genetically engineering baculovirus to express a gene that encodes an influenza coat protein such as hemagglutinin or neuraminidase. A recent NIAID-supported Phase II clinical trial of a vaccine produced by Protein Sciences Corporation using this strategy showed that it is well tolerated and immunogenic; the company is conducting further clinical evaluation of this product."
It would seem to me that rather than creating a vaccine against a single 
HA or neuraminidase, it'd make sense to create a vaccine against 
a COCKTAIL of all 16 HA's and all 9 Neuraminidases (along with a promoter).
Presumably, this might give a very broad initial immunity to the general
population which could then  - if and only if necessary - be supplemented with the more traditional last minute specialized/ad-hoc vaccines that change every 6 months or so.
Does anyone know if these folks &/or other researchers are doing this ?
Regards, 129.78.64.100 10:58, 20 February 2007 (UTC)
replies: text: You ask:Can a cocktail of HA1..HA16 and N1..N9 be used directly as a flu vaccine with a promoter? The answer is no. Each year a highly specific vaccine is make for the three exact strains most likely to be the major strains, and if the strain is even moderately different, the vaccine doesn't work. So we would need to create a vaccine for every possible stain (trillions at least), not just every possible subtype. Further the vaccine wears off somewhat over time. There is an attempt to create a vaccine using the M2 protein which doesn't mutate much, but as it is underneath the H and N proteins, a relative lack of access to it by antibodies makes the idea iffy. See H5N1 clinical trials for what H5N1 vaccines are under clinical trial.WAS 4.250 22:57, 20 February 2007 (UTC)
thread_title: Can a cocktail of HA1..HA16 and N1..N9 be used [[directly]] as a flu vaccine with a promoter?

message: "Crowding out the invading influenza" is a possibility. See Treatment 'to neutralise all flu' - 69.6.162.160 00:35, 4 October 2006 (UTC)
replies: text: The article says "Professor Nigel Dimmock has spent more than two decades developing the new approach. To create the 'protecting virus' he deleted around 80% of the genetic material of one of the eight RNA segments that make up the flu virus. This deletion makes the virus harmless and prevents it from reproducing by itself within a cell, so that it cannot spread like a normal influenza virus. However, if it is joined in the cell by another influenza virus, it retains its harmless nature but starts to reproduce - and at a much faster rate than the new influenza virus. This fast reproduction rate - spurred by the new flu infection - means that the new invading influenza is effectively crowded out." This is not junk science, but as the article also says "This is cutting edge science, but there is a lot that could still go wrong." WAS 4.250 01:49, 4 October 2006 (UTC)
replies: text: Another promising approach is the discovery of a peptide which could prevent "numerous subtypes" of flu.If that isn't enough, maybe a combination of approaches would be. 69.6.162.160 02:55, 5 October 2006 (UTC)
replies: text: There is enough government money and venture capital available that anyone with an idea is floating it in press releases trying to get funding. Whether any of it will pay off or not is unknown. But traditional approaches are being funded along side new ideas and between Jan 2007 and Jan 2009 the world will see solutions available. I just hope we see solutions before a pandemic rather than after. If the pandemic comes too soon all we'll have is prepandemic vaccines for a few million people that might make a deadly flu into a nondeadly flu for those who get the prepandemic vaccine. WAS 4.250 05:56, 5 October 2006 (UTC)
thread_title: Treatment 'to neutralise all flu'

message: "What is unique about our technology is its ability to remove viruses--the smallest of the pathogens--from water supplies," Pei Chiu, an associate professor in UD's Department of Civil and Environmental Engineering, said.  Brian Pearson 02:54, 28 May 2007 (UTC)
thread_title:  New UD technology removes viruses from water 

message: I can sorta understand why other "Flu" articles use shorthand, but this an article about actual science. Am I gonna be shot down if I suggest we use complete words, please?--ZayZayEM 07:46, 7 August 2007 (UTC)
replies: text: I don't care one way or the other. I care about the data. I don't care much about how we present the data. Tim is real big on presentation as well as accuracy and use of the best possible sources. If Tim agrees, then go ahead and move the article. WAS 4.250 16:53, 7 August 2007 (UTC)
thread_title:  Move to [[Influenza research]] 

message: Why is the article Spanish flu research transcluded into this article, and not put in Summary Style?--ZayZayEM 02:44, 24 October 2007 (UTC)
replies: text: Spanish flu research belongs equally in Spanish flu and in Flu research and both articles are very short so putting all of Spanish flu research in both made sense to me. It was also a chance to try transclusion in something other than a template and I wanted to experiment with that. Since it is done so infrequently, there have been minor incidents where people have made changes not realising that the three are glued together and do not exist independently. The result of the experiment is that it is very do-able but since it confuses people I can't recommend it as standard practice. In any case, summary style is also an option if you want to go that route. By the way, Spanish flu needs to be completely rewritten from scratch using sources from this century. Much of what was believed about it has been discovered to be questionable or wrong, but what is in the article right now is backed by modern data I think. WAS 4.250 14:36, 24 October 2007 (UTC)
replies: text: Please understand Summary Style. Transculsion defeats the purpose. Results in duplicate information and lengthy TLDR-style articles.--ZayZayEM (talk) 05:36, 23 October 2008 (UTC)
thread_title:  Spanish flu transclusion 

message: Prior to HIV/AIDS - Influenza was recognised as the centrepoint of focus for infectious-disease research.
History and context of Influenza research is dissapointingly almost completely absent from this article, instead a focus primarily on Avian influenza (A subtype H5N1) and modern pandemic threat assessment (and hysteria).
Tagging article for cleanup (it needs a DIET) and expert attention.
Tagged for rewrite, blatantly innacurate, misleading and confusing sentances and facts arev rife.
*"hoped", whose hopes? is that really encyclopedic lnaguage/tone
*very poor less-than-layman terminology
*bird-flu focus
The expert no one knows list:
*removed as per previous discussions with WAS, this list is wholly unrepresentative of the sources. It is cherry picking and quotemining for a serious rack. Also very h5N1 specific
*I'm assuming this is dealing with a pandemic? This srticle is about influenza. Not specific strategies to deal with the onset of a modern influenza pandemic.
*H5N1 specific
...and so on.
--ZayZayEM (talk) 05:39, 23 October 2008 (UTC)
thread_title:  Context, history, and more context 

message: Some sections seem biased to Avian/H5N1 pandemic flu.   Other influenza articles overlap a lot with this one.
Influenza research is a very general name - probably the content should be divided amongst the various subtopic articles (each of which can have a Research section) and then this one can almost be a disambiguation page linking to various articles/sections on specific types of research :
- vaccine production methods, seasonal flu, pandemic flu, vaccine trials, antivirals.
It would probably make future maintenance much easier. 
Any objections to gutting this article ? Rod57 (talk) 10:48, 6 October 2010 (UTC)
thread_title:  Rename or rewrite  

message: Hello fellow Wikipedians,
I have just added archive links to  on Influenza research. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive http://web.archive.org/web/20121025220534/http://news.yahoo.com/s/ap/20060504/ap_on_he_me/bird_flu_vaccines;_ylt=Aj2.Gt3UoBIu7slikJhzGCSs0NUE;_ylu=X3oDMTA2Z2szazkxBHNlYwN0bQ-- to http://news.yahoo.com/s/ap/20060504/ap_on_he_me/bird_flu_vaccines;_ylt=Aj2.Gt3UoBIu7slikJhzGCSs0NUE;_ylu=X3oDMTA2Z2szazkxBHNlYwN0bQ--
When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at ).
Cheers.—cyberbot IITalk to my owner:Online 23:46, 29 February 2016 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Influenza research. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20090427092000/http://ecam.oxfordjournals.org/cgi/content/full/2/3/285 to http://ecam.oxfordjournals.org/cgi/content/full/2/3/285
*Added archive https://web.archive.org/web/20100308121756/https://www3.niaid.nih.gov/news/newsreleases/2004/flucontracts.htm to http://www3.niaid.nih.gov/news/newsreleases/2004/flucontracts.htm
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 17:44, 18 September 2017 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just modified 2 external links on Influenza research. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added  tag to http://jvi.asm.org/cgi/content/full/80/4/1959i
*Added archive https://web.archive.org/web/20120928131345/http://www.hhs.gov/pandemicflu/plan/appendixd.html to https://www.hhs.gov/pandemicflu/plan/appendixd.html
*Added archive https://web.archive.org/web/20071217093827/http://www.oie.int/eng/publicat/RT/A_RT26_1_et_26_2.htm to http://www.oie.int/eng/publicat/rt/A_RT26_1_et_26_2.htm
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
Cheers.—InternetArchiveBot (Report bug) 20:00, 13 November 2017 (UTC)
thread_title:  External links modified