Talk:Paliperidone

message: Paliperidone is the brand name of an extended release formula of the longer acting 9-hydroxy metabolite of the antipsychotic known as Risperidone.  Since some of the activity of risperidone is due to this active metabolite, one would expect there to be many similarities in effiacy and adverse effects between risperidone and paliperidone. Since it is a new and unique compound, it is still given patent protection. It is unclear as of yet what advantages, if any, it has over the parent compound. Since some of the effects of risperidone are due to the actual "parent" drug, there may be some differences between the two drugs but it is unclear as of yet whether or not this is the case.  It is due to be released by or in early 2007. 
Paliperidone is the major active metabolite of risperidone, it is differentiated from risperidone by the addition of one hydroxy group. It is certainly going to be licenced/marketed as a different drug and will nicely provide Janssen with a patented drug once Risperdal loses its. Colin°Talk 20:18, 4 June 2006 (UTC)
thread_title: Paliperidone

message: Not that I have any medical credentials, but I have read that risperidone metabolizes into a number of non-paliperidone components which could potentially cause side-effects.  By taking paliperidone such side-effects would be avoided.  It might be safe to say that paliperidone is a "purified" risperidone.
72.192.204.89 01:37, 15 August 2007 (UTC)
thread_title:  Paliperidone vs. Risperidone 

message: I was told Invega was a reverse isotope of Risperidone (sold as Riperdol 2)  ;)  I bet my doctor was wrong.  Yeah, I took it.  —Preceding unsigned comment added by 72.23.108.110 (talk) 07:51, 21 November 2007 (UTC)
thread_title: Rumor

message: I believe the name is: (9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-9-​hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one
and the structure should be reflected to display that. See the molecule here: http://www.chemspider.com/Chemical-Structure.7978307.html  —Preceding unsigned comment added by ChemSpiderMan (talk • contribs) 03:28, 22 May 2008 (UTC)
replies: text: Will fix this as soon as I get to my main computer (i.e. the one with ChemSketch :) Fvasconcellos (t·c) 17:02, 25 May 2008 (UTC)
replies: text: Done. Fvasconcellos (t·c) 14:34, 29 May 2008 (UTC)
thread_title:  Structure and name are lacking a stereocenter 

message: At this version, the page is very similar to the link given at the bottom: http://www.prescribingreference.com/products/showProducts/which/Invega, for which what appears to be a privately held company holds a copyright. (See the section on Adverse Reactions.) modify 03:34, 22 May 2008 (UTC)
replies: text: Removed. Since it was accurate information, it should be reworded and returned to the article eventually. Fvasconcellos (t·c) 17:09, 25 May 2008 (UTC)
thread_title:  Possible copyright violation 

message: this article references Jannsen pharmaceuticals, while the older risperdone article mentions Janssen-Cilag, but not until i went to the Cilag page was the reference made clear, the marketing company goes by the name janssen-Cilag, while products are marketed as either Janssen of cilag, depending on what the product is and where in the world it's being sold. It's a bit confusing the way the pages are now, if you don't read the section in cilag, which is only really marketed in europe, then you just wonder why there is a stub article link on the risperdone page.Kesuki (talk) 02:15, 22 July 2008 (UTC)
thread_title:  Janssen vs Janssen-Cilag 

message: Please note, that paliperidone (as pharmaceutical product) is not a single enantiomer. It's a racemate of both (R) and (S) enantiomers; see e.g. full INVEGA U.S. Prescribing Information:
"INVEGA®
contains a racemic mixture of (+)- and (-)- paliperidone. The chemical name is (±)-3-[2-[4-
(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4
H-pyrido[1,2-a]pyrimidin-4-one."
(accessed on December 3, 2008). No idea why ChemSpider displays the (R) enantiomer. Cheers.--84.163.111.35 (talk) 05:27, 3 December 2008 (UTC)
replies: text: ... will be corrected soon. --Jü (talk) 08:11, 16 August 2009 (UTC)
replies: text: ... done. Best regards, --Jü (talk) 15:07, 16 August 2009 (UTC)
thread_title:  Stereochemistry incorrect 

message: In the pharmacology section it is stated that Invega will be marketed for bipolar mania. What is the source for this I was unable to find it. 
I also don't understand this part "The drug significantly reduces side-effects present in other anti-psychotic drugs formerly used to treat both schizophrenia as well as bipolar disorder[citation needed]." Invega's side effects are just as bad as all the other atypical antipsychotics. In fact Invega's most common side effects are headache (no big deal) and tachycardia (big deal). Really the only thing that makes Invega any better than Risperdol is that the Invega doesn't have to be so hard core processed by your liver.
Girrl88 (talk) 17:23, 8 March 2009 (UTC)
thread_title:  Possible Copyright Violation 

message: Here's some more information about invega which should be useful. http://www.nature.com/mp/journal/v13/n1/full/4002066a.html
150.203.110.137 (talk) 18:24, 15 August 2009 (UTC)
thread_title: more info