Talk:Nucleosome

message: I propose that we replace the small and redundant information found in the core particle page with a redirect to this page.  Any comments?  Would anybody oppose if I added a redirect from that page to this one? -RockyRaccoon 03:36, 3 April 2006 (UTC)
replies: text: "A chain of nucleosomes can be arranged in a 30-nm-fiber, a compacted structure (once thought to be a helical solenoid, but now considered likely to exist as a zig-zag structure in vivo)"
It seems to me that the idea that 30-nm-fiber is not a solenoid but a zig-zag could be very controversial. Study books, such as Genes VIII by Benjamin Lewin, depict the structure as a solenoid as late as 2003. What source is used to make a claim for zig-zag structure? --EnSamulili 16:22, 15 Mar 2005 (UTC)
thread_title: Merge [[Nucleosome core particle]] with this one?

message: :A nucleosome is the fundamental repeating subunit of eukaryotic DNA, and is made up of DNA and...
How can a nucleosume be a subunit of something which it comprises?  Do you mean eukaryotic chromatin? 129.7.56.177 05:42, 12 February 2006 (UTC)
replies: text: Changed it. -EnSamulili 14:43, 12 February 2006 (UTC)
thread_title:  Recursive definition 

message: User:TimVickers produced the following image which I nominated for deletion last week because it wasn't being used anywhere.  User:Deryck Chan was nice enough to look through my nominations at my request and thought that this one was worth saving, and might be useful on this article. ~ BigrTex 17:10, 5 February 2007 (UTC)
thread_title:  Possible image 

message: I removed this exception in the introduction. It is unsourced, and a cursory PubMed search proves that this statement isn't true, or at least not universally true (see: ). This might be an old vandalism that never got replaced? If anyone wants this statement to stay, then please cite a source. --chodges (talk) 22:52, 12 February 2008 (UTC)
replies: text: Oops, I didn't read enough. Cited this statement in the article. --chodges (talk) 23:03, 12 February 2008 (UTC)
thread_title:  Nucleosome a repeating chromatin unit, except in sperm 

message: the current text is incorrect. Swi/Snf is not essential for yeast viability. It is however normally required for expression of a certain subset of genes which is subsequently overcome in the presence of particular point mutations within histones (sin mutations)  Swi/Snf independence mutations
Ging3rnut (talk) 23:05, 15 July 2008 (UTC)
thread_title: sin mutations

message: Hi everybody, I rewrote the whole article based on the papers cited - I felt that the original article was in really bad shape and needed a complete work over. I feel that now several points are made clearer and some of the less related stuff like chromatin and SIN has been reduced to what is necessary. What do you think? Greetings --hroest 00:21, 27 July 2008 (UTC)
thread_title:  New article 

message: Some time ago, the following section was added; then this correction was made, which corrects a mistake.
It seems to me that the nucleosomes are not just missing in the promotor region but rather organized while some variants seem to be enriched there:
:Nucleosomes are highly organized at the 5' end of genes and this organization spreads into the adjacent coding sequence. A short nucleosome-free region (NFR, which varies in size from gene to gene) typically lies upstream of nucleosome +1 (the first nucleosome upstream of the translation start site), and is the predominant site for transcription-factor-binding at promoters. Whitehouse et al
:The arrangement of nucleosomes at pol II promoters is now established4, 5, 6, 9 as H2A.Z nucleosomes flanking a nucleosome-free promoter region. Albert et al
I think the way the article states it is too simplified regarding these studies, we probably should include one of the above statements from the paper, what do you think? Greetings --hroest 09:08, 25 February 2009 (UTC)
thread_title:  at promotors 

message: I hope nobody minds, I updated the page with info about replication origins being depleted for bulk nucleosomes (the Albert 2007 paper touched on this, as have a number of other genome-wide nucleosome papers) and precisely positioning nucleosomes (shown genome-wide in Eaton 2010). I thought some elements other than TSSs should get some love. Someone might also wanted to include insulators (I think human CTCF has been shown to have a strong nucleosome positioning effect?) Soaring brick (talk) 16:26, 17 August 2010 (UTC)
thread_title:  Other nucleosome positioning signals 

message: Boy 117.202.247.83 (talk) 04:18, 7 July 2022 (UTC)
thread_title:  Nucleosome