Talk:Pyridoxal phosphate

message: There is one in vitro study indicating that an overdose of B6 kills cell cultures, while P5P does not. It is assumed that ingesting P5P will be harmless. This is plausible but unproven, so I changed "will" to "perhaps might". 
Jethomas5 (talk) 15:56, 6 July 2023 (UTC)
thread_title: Toxicity

message: I'm redirecting this to Vitamin B6; anyone feel free to expand it into an article if you have something to say about apart from what's covered in Vitamin B6. — Knowledge Seeker দ 7 July 2005 06:44 (UTC)
Metabolized into what? Biological Synthesis section needs expansion. --SuperstrainX5 (talk) 13:03, 25 March 2008 (UTC)
thread_title: Untitled

message: Can anybody tell me the percentage of vitamin B6 (activity) in pyridoxal phosphate? itsme (talk) 14:34, 3 August 2009 (UTC)
thread_title: Percentage of vitamine B6 activity

message: In the last reaction shown in the reaction scheme, it should read 'NH3', not 'NH2', right?  — Preceding unsigned comment added by Gncs (talk • contribs) 14:59, 23 November 2013 (UTC)
replies: text: @Gncs Yes, indeed. As well, as the lysine should be deprotonated in the previous step. Der Hanke (talk) 22:02, 30 July 2022 (UTC)
thread_title:  Catalytic mechanism (Scheme) 

message: The IUPAC name is listed as '[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid', which (obviously) seems wrong to me, and according to the structure depicted. Said structure clearly depicts an X-methyl phosphate and not an X-methoxy phosphonic acid, since it does not contain any C-P bond. Please note, I am no expert on the topical biochemistry. I am, however, certain about the chemical nomenclature, even though http://www.chemicalize.org/structure/#!mol=pyridoxal+phosphate&source=fp agrees with the given name. Sadly. 
Nicolas Seufert (talk) 01:33, 22 January 2014 (UTC)
thread_title:  IUPAC name 

message: If "the L in PLP does not indicate a levorotatory chiral center", then what DOES it stand for? The given information is almost as useless as saying nothing, isn't it?. I've looked it up on the web but couldn't get a proper answer... Thanks.
--91.117.64.67 (talk) 15:58, 8 June 2016 (UTC)
thread_title:  Etymology 

message: Moving here, as this is unsourced, per WP:PRESERVE.  The content is also not encyclopedic - we don't say things like, "it should be noted..."  See WP:MOS
;Etymology
PLP stands for pyridoxal 5' phosphate and PMP stands for pyridoxamine 5' phosphate. Consequently, the L in PLP does not indicate a levorotatory chiral center.
The common names pyridoxamine (aminomethyl group at position 4), pyroxidal (carbaldehyde group) and pyridoxine (alkaloid, has hydroxymethyl) derive from pyridine + oxy + a IUPAC suffix.Pyridine, in turn, comes from the Greek πῦρ, πυρός (pyr, fire) + -ide + -ine.
It should be noted that the oxy infix in pyridoxine is not based on Hantzsch–Widman nomenclature (the heterocyclic ring is simply a modified pyridine) and the pyr- root does not indicate it to be a dimeric acid anhydride (unlike pyrophosphate).
-- Jytdog (talk) 16:09, 8 June 2016 (UTC)
thread_title:  Unsourced 

message: Note: What does it means by the term "transaldiminated"? What is the formal definition for the term "transaldimination"? One of the few journals that used the term "transaldimination" is from NCBI by Moore PS, Dominici P and Voltattorni CB (https://www.ncbi.nlm.nih.gov/pubmed/8789463). Another more recent publication from the Russian Journal of General Chemistry by F. V. Pishchugin (http://link.springer.com/article/10.1134/S1070363213060121). If the term "transaldimination" indeed acceptable, can a clear definition and a page be made about it? Are there any alternative terms that can explain this concept clearly and precisely?  — Preceding unsigned comment added by Zyvov (talk • contribs) 02:54, 21 October 2016 (UTC)
replies: text: @Zyvov trans, as a prefix is very well accepted, I guess. It is used in many publications and reaction types as a descriptive term, like trans-metallation, trans-esterification, trans-aminase, ect.
I think the meaning of trans-aldimination should be clear enough. Der Hanke (talk) 22:17, 30 July 2022 (UTC)
thread_title: transaldiminated