Talk:Maturity-onset diabetes of the young

message: I am surprised you think that "most diabetes clinics in the world are testing" for these mutations. My impression is the most diabetes clinics have yet to hear of this! There have been at least 1 case each up to 7 and 8 months of age, and a new article has the record: 17 months with as)ymptomatic family members for the R176C mutation (Fletchner et al Diabetes Metab 2006;32:569-580)Lphilipson 06:07, 27 February 2007 (UTC)
replies: text: Go ahead and change the age limit, but I think the testing is still targeted at those with onset before 6 mos. As to being looked for, there have been presentations about this for the last 2 years at all the major diabetes meetings. Every time a pediatric endocrinologist does a diabetes update, we mention it. We have finally picked up our first case after looking for 2 years. I hope there are no longer any diabetes specialists who take care of children who havent heard of it by now! alteripse 09:09, 1 March 2007 (UTC)
thread_title: response

message: We should talk directly. Our center in Chicago now has 10 patients since August, and in my conversations with Andrew Hattersley a couple of weeks ago in France we agreed that there are not more than about 25 patients in the USA. His total is about 360 PND cases, with about 160 off insulin. We are actively working to identify new cases and uncover additional mutations. The case at 17 months by the way was mis-labeled - it was clearly not PND. Our average age remains about 3 months with most cases even earlier. We are about to launch a national registry to try and follow more of these cases - would love to include your case. My conversations with ped and adult endos continues to suggest that the information penetrance is less then we might hope - and some of them are very skeptical. My email address is Lphilipson
*Don't post your email in public. If you look at my user page, you can send a direct email to me. I am checking your user page to see if your email is enabled and will post to you. alteripse 10:32, 6 April 2007 (UTC)
thread_title: We should talk directly

message: Cases of MODY in China appear to be largely unexplained by the genes associated with MODY in Western populations.
:This paper actually does not support this assertion. If you read the abstract, they used an obsolete definition of MODY that simply includes any pair of relatives with any non-type 1 diabetes of which one member was diagnosed before age 25. They found several cases of recognizable MODY and in several cases could not identify the genetic cause. As cases of ordinary type 2 were not excluded by their selection criteria, it doesn't look like their findings supported the sentence I removed. It can be re-inserted with better supporting evidence. alteripse (talk) 21:22, 22 November 2009 (UTC)
thread_title: why chinese sentence and reference were removed

message: There's 30 types of "monogenic diabetes" doi:10.1210/er.2015-1116. JFW | T@lk 14:09, 3 April 2016 (UTC)
thread_title:  Review 

message: Both MODY 2 and MODY 3 are described as associated with 30-70% of cases, which makes a total of more than 100%. --CopperKettle 19:17, 19 January 2019 (UTC)
replies: text: Or is could only add up to 60%. Natureium (talk) 20:06, 19 January 2019 (UTC)
thread_title: Figures in the table don't seem to add up