Talk:Myristicin

message: "It causes brain damage." Is there a source for this claim, is it an absolutely known and demonstrated fact, or just a supposition, and even if supposed, what studies support this? Whig 04:07, 7 Jun 2005 (UTC)
thread_title: Source question

message: The "probable neurotoxic effects" also need to be properly sourced, and while I would rather not remove information which may in fact be well-established, there seems to be a POV here against use of nutmeg for psychoactive effects, based on the claim that it causes permanent harm, which may or may not even be true. Whig 04:12, 7 Jun 2005 (UTC)
thread_title: NPOV dispute

message: Hello fellow Wikipedians,
I have just modified 2 external links on Myristicin. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
*Added archive https://web.archive.org/web/20120328162245/http://www.lktlabs.com/products/Myristicin-126-50.html to http://www.lktlabs.com/products/Myristicin-126-50.html
*Added archive https://web.archive.org/web/20120716213845/http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/Myristicin.pdf to http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/Myristicin.pdf
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thread_title:  External links modified (February 2018) 

message: ...and editing and return to article, if other editors warrant its inclusion. Here are the parts that were removed, as noted in the Edit summaries, because the content was poorly sourced, or distorted the scope away from many studies of licit uses, to illicit uses of the compound. As well, placing long lists of primary sources at end of paragraph was seen to be a problem, because it ignores WP guidelines (requiring secondary sources), and reduces reader confidence because it makes verifiability of individual facts very difficult. Here is the portion of text moved here:
Nutmeg has psychoactive properties at doses much higher than used in cooking. Although these intoxications may be ascribed to the actions of myristicin, it is likely that other components of nutmeg may also be involved, as ingestion of pure myristicin has been found not to produce the same results obtained from ingestion of the entire nutmeg. ...
Intoxications with nutmeg had effects that varied from person to person, but were often reported to be an excited and confused state with headaches, nausea and dizziness, dry mouth, bloodshot eyes and memory disturbances. Nutmeg was also reported to induce hallucinogenic effects, such as visual distortions and paranoid ideation. Most patients with accidental nutmeg intoxication experience high anxiety and an impending sense of doom after the initial excitation. In the reports, nutmeg intoxication took several hours before maximum effect was reached. Effects and after-effects lasted up to several days.
If editors have the time, please review the material against the sources provided, decide if the material is useful in the article with the new Use content that was added, find relevant secondary sources (to substantiate what is now primary source-only material), remove any material inaccurate to good secondary sources, and return the useful and properly sourced content to the article. 2601:246:C700:2DB2:48E8:C38:B886:A274 (talk) 00:34, 9 June 2019 (UTC)
thread_title:  Material from "Uses" section moved here for further review 

message: In my opinion, the two references listed do not support that myristicin has anticholigernic properties.
Both are secondary sources that can be tracked back to a case report that goes misrepresented:
* The case report of hospitalization is of nutmeg intoxication, not myristicin.
* The case report merely observes the symptoms of nutmeg intoxication resemble the presentation of anticholinergic toxidrome. In fact, the case report remarks that it should not be confused with nutmeg intoxication in the ER. It then states that myristicin is thought to be the principal cause of nutmeg intoxication, which is what the two references seem to have clung onto.
Note for editors:
Conflating the effects of myristcin with those of nutmeg is common. Although myristicin is thought to be the main culprit of nutmeg intoxication in the medical world, conclusions about myristicin as an isolated chemical should not be taken from observations of nutmeg. It is not the only substance with pharmacological relevance present in nutmeg. 
— Tyryny (talk) 21:39, 21 June 2021 (UTC)
thread_title:  Sources do not cover claim that myristicin has anticholinergic toxicity 

message: but ? (suggest "that seems") unlikely since no MMDA was found in urine, in the body it produces hallucinogenic effects, - & change both ,s to ;s
Physiological effects - Psychoactive effects - elemicin, eugenol, and safrole - capitalize Elemicin
you see everything glitch all around you, breath? (presumably should be breathe), and morph
Overall, nutmeg is more alike? to? that? of? (change to like) a cannabinoid
Metabolites - Myristicin is also formed? (suggest transformed) into demethylenylmyristicin, (change , to &) dihydroxymyristicin, (recommend changing , to . & deleting rest of sentence)
Research on breakdown of myristicin. - sentence fragment
Toxicity - P450 enzymes in humans, which is (change to are) responsible
71.114.47.49 (talk) 04:56, 3 January 2023 (UTC)
thread_title:  assorted problems