Talk:Azide-alkyne Huisgen cycloaddition

message: Question:  Does anybody beside Tim or his labmates call the triazole catalyst "Tim's catalyst"?  Is this in the literature, or is it a misuse of Wikipedia?  In any case, I agree that this article does a poor job of summarizing the utility and mechanism of this increasingly important reaction, and look forward to having the time to correct it.134.84.138.62 17:57, 12 February 2007 (UTC)

message: , that the Huisgen 1,3 dipolar cycloaddition is only the reaction of alkynes with azides:
“Huisgen Cycloadditions are exergonic fusion processes that unite two unsaturated reactants and provide fast access to an enormous variety of five-membered Heterocycles”. Sharpless, Angew. Chem. Int. Ed., 2002, 41, 2596
In addition, the copper-catalyzed version is NOT a 1,3-dipolar addition, because it is stepwise. The links to copper-catalyzed variants are not helpful. I strongly recommend to reedit the whole article.
In addition I have searched "Huisgen Cycloaddition" in Scifinder, showing up the following publications which have nothing to do with alkynes and azides:
Domingo, Luis R.; Picher, M. Teresa.  A DFT study of the Huisgen 1,3-dipolar cycloaddition between hindered thiocarbonyl ylides and tetracyanoethylene.    Tetrahedron  (2004),  60(23),  5053-5058.  CODEN: TETRAB  ISSN:0040-4020.  CAN 141:123296  AN 2004:404880    CAPLUS
Singal, Kewal Krishan; Giare, Rubina.  "Huisgen reaction" of diarylnitrilimines with N-arylmaleimides leading to the synthesis of 1-(2,4-dibromophenyl)-3,5-diaryl-3a,4,6,6a-tetrahydro-1H,5H-pyrrolo[3,4-c]pyrazole-4,6-diones.    Indian Journal of Heterocyclic Chemistry  (1998),  8(2),  121-124.  CODEN: IJCHEI  ISSN:0971-1627.  CAN 130:237509  AN 1999:68719    CAPLUS
Sustmann, Reiner.  Rolf Huisgen's contribution to organic chemistry, emphasizing 1,3-dipolar cycloadditions.    Heterocycles  (1995),  40(1),  1-18.  CODEN: HTCYAM  ISSN:0385-5414.  CAN 122:132224  AN 1995:332236    CAPLUS
Butler, Richard N.; Coyne, Anthony G.; Cunningham, William J.; Moloney, Eamon M.; Burke, Luke A.  Water and the Huisgen cycloaddition reaction: A focus on polar contributions to the transition state in the reactions of dicyano(phthalazinium)methanide with substituted styrenes and benzylidene acetones.    Helvetica Chimica Acta  (2005),  88(7),  1611-1629.  CODEN: HCACAV  ISSN:0018-019X.  AN 2005:842555    CAPLUS
* I have reverted your edits because your edit was simply not according to Wiki guidelines (start with definition and article name in bold bold, no references to the discussion page)
* your Sharpless 2002 definition appears to me the definition reserved for click chemistry.
* I can also see from your references that the huisgen reaction is used in a liberal way. The 1998 article title has Huisgen reaction between parenthesis, maybe that solves the question
* concerning the stepwise vs 1,3-dipolar reaction type: I have provided literature that says 1,3-dipolar, if you have literature that says otherwise plase make an edit and broaden the article 
* please do make edits as you seem fit but do consult the Wiki guidelines  V8rik 18:03, 2 October 2005 (UTC)
thread_title: I have certain doubts

message: I am not sure if this is the page to make such remarks BUT I would like to say that I am surprised with the selection of bibliography concerning the 1,3-dipolar azide alkyne cycloaddition ...  It seems focused on minor contributions and totally ignoring the pioneers. Any expert on the field would find that this is  NOT the appropriate scientific documentation. This is why, scientific articles should be signed.
: Yes, this is the place to make such remarks.  The great thing about Wikipedia is that if you don't like the article the way that it is, you can make whatever changes you feel would improve it. (Keep in mind though, that this is intended to be an encyclopia article, not a scientific publication, so the standards for "appropriate scientific documentation" are going to be lower.) Please feel free to add whichever references you think are appropriate.    Wikipedia articles get better when people like you and their knowledge.  And finally, this article is "signed" in the sense that changes are tracked and each person's contributions can be determined. Edgar181 14:36, 4 December 2005 (UTC)
thread_title:  proper bibliography 

message: The final figure of the article referring to ruthenium catalyzed variants (mysteriously captioned within the picture as "figure 2...") does not contain Cp* but, rather, its protonated analogue. Indeed, the precatalyst (as shown) is a 16e- species as opposed to the correct 18e- Cp*RuL2X. This figures should likely be replaced with one that fixes this inaccuracy and is an original work (as opposed to a likely screencap).  
Jgwest91 (talk) 04:33, 31 July 2013 (UTC)
thread_title:  Figure Error: "Cp*"