Talk:Ethylenediaminetetraacetic acid

message: A NIH study with the acronym TACT is supportive of chelation therapy.  Review articles are describing this NIH study.  Perhaps a PhD scientist or physician could update the main page. "Chelation reduced adverse cardiovascular events in a post myocardial infarction (MI) population. Patients with diabetes demonstrated even greater benefit, with a number needed to treat of 6.5 patients to prevent a cardiac event over 5 years, with a 41% relative reduction in risk of a cardiac event (p = 0.0002)."  a pubmed reference is PMID: 27149141
:::Dangerous substance? 
::In some countries. Contre the seller Tetra - and also Di - Sodium EDTA . Make  "the Safari " , -  the public prosecutor and agents. Everyone diligently checks imported food and medicine. Remove everything , - with EDTA content from marche. With consequences for the seller.Smokefood (talk) 13:10, 4 April 2024 (UTC)
thread_title: EDTA chelation therapy supported at NIH study

message: We have an insert on this page that seems to weaken the notion that EDTA bonds to divalent ions. Is one of us going to have to look up association constants for this compound in order to determine specificity? The way the text reads, you would think you could use EDTA to scavenge things like octavalent osmium. Dwmyers 16:21, 20 Sep 2003 (UTC)
replies: text: It was me who added "trivalent", for I had in mind that Iron(III)-EDTA is more stable than Iron(II)-EDTA... Actually I'm not sure where to draw the line; e.g. I never heard of any EDTA-Complex with a more than trivalent metal, but can't exclude the possibility... Maybe you'll just delete the "etc."? Malbi 13:22, 27 Sep 2003 (UTC)
thread_title: EDTA bonds

message: Ever since I was old enough to read (which was a pretty young age), I've seen tetrasodium edta in a lot of crap.  Is it easily synthesized and not toxic enough a chelating agent in its produced concentrations to worry?  In sum, WTF?  It's not like I'm worried about additives, but they better at least have a real purpose--how does it preserve foods, and why do we use it instead of something else?
-Todan
EDTA and its derivatives such as Disodium or Tetrasodium are not a preservative per se. They aid preservation by sequestering metal ions in solutions, and impairing bacterial growth effectively "starving" the bugs of neutrients. They make the preservative added more effective. Pedantic I know
:tetrasodium edta redirects here, although there seems to be no mention of it in the article. This seems to be happening more and more. It is the worst option and must be wasting a lot of time for a lot of people. A null result, an empty stub, or a stub suggesting relevant articles would all be better for users.--Alkhowarizmi (talk) 04:43, 15 December 2018 (UTC)
replies: text: --Smokefoot (talk) 13:16, 15 December 2018 (UTC)
thread_title:  tetrasodium edta 

message: Is there a source for the longest Scrabble word assertion? Isopropyl 04:37, 24 March 2006 (UTC)
thread_title:  Scrabble trivia 

message: In the Uses section, it is stated, "Note that EDTA causes lead to be relocated in the human body into the brain so its use as an antidote has been discontinued."  I have never read this, is there a citation of any sort? George100 16:41, 1 June 2006 (UTC)
thread_title: EDTA causes lead to be relocated to the brain?

message: Can someone clean-up the "blade 2" reference in the trivia section (if it's even necessary to have this information in the acticle)? I know there's a movie, but isn't there a video game and also a TV series. Should it be "blade 2" or "Blade 2"? Also, a link to the movie/game/TV series would be useful. I've never seen that movie or the TV show or played the game otherwise I would change it myself. dq 21:53, 12 September 2006 (UTC)
thread_title:  blade 2 

message: The main article is seeking a citation for this - There is a good page on it at http://www.mztech.fsnet.co.uk/electrics/elc_edta.html if that helps. I have no idea how to add citations so somebody else may want to alter it.
Lawrie 13:28, 12 April 2007 (UTC)
thread_title:  Recycling Lead Acid Batteries 

message: If anyone is interested, the IUPAC nomenclature should be 2-(carboxy(2-(carboxy(1-hydroxy-2-oxoethyl)amino)ethyl)amino)acetic acid, though I might be wrong. Just incase anyone is interested.
24.136.88.151 02:35, 4 July 2007 (UTC)
thread_title:  IUPAC nomenclature 

message: User Edgar removed my findings on EDTA that were obtained from US government servers and are publicly available under the Freedom of Information Act. This information was removed from the page citing a copyright violation? How does information reposted from a public government server constitute a copyright violation. This seems like a deliberate attempt to suppress information regarding this compound and its increasing use in a variety of food products as a preservative.  —Preceding unsigned comment added by Ianocmedia (talk • contribs) 18:26, 3 December 2007 (UTC)
replies: text: The material you added is a direct copy of text published by the International Journal of Toxicology and is copyrighted.  PubMed has been given the rights to reproduce the abstract on its webpages.  Wikipedia does not have the rights do so.  Feel free to summarize the results and add it to the text, if you like. --Ed (Edgar181) 18:36, 3 December 2007 (UTC)
thread_title:  Why is relevant info regaurding the toxicity of this compound being removed from this page? 

message: Check out this FDA article. According to them, the chelator for lead is  "Calcium Disodium Versenate" with the chemical name of edetate calcium disodium. The other is simply edetate disodium, marketed as Endrate. The FDA says that the former, edetate disodium, has caused 11 deaths. I think we need to make clear the distinction on this page, to clarify and help avoid future deaths. ImpIn | (t - c) 08:46, 6 June 2008 (UTC)
thread_title:  Two different drugs called EDTA 

message: This article talk page was automatically added with  banner as it falls under :Category:Food or one of its subcategories. If you find this addition an error, Kindly undo the changes and update the inappropriate categories if needed. The bot was instructed to tagg these articles upon consenus from WikiProject Food and drink. You can find the related request for tagging here . Maximum and careful attention was done to avoid any wrongly tagging any categories , but mistakes may happen... If you have concerns , please inform on the project talk page -- TinucherianBot (talk) 01:23, 4 July 2008 (UTC)
thread_title: [[WP:FOOD|WikiProject Food and drink]] Tagging

message: I think the article should talk about the physical properties of EDTA, such as color, solubility in water and in oil at various pH levels and temperatures, and perhaps even boiling and melting points. The solubility is especially important, because of the wide use of EDTA and its toxicity. -Pgan002 (talk) 12:08, 21 February 2009 (UTC)
replies: text: Great suggestions that we revise this report some more.  The term EDTA means different things to different people.  To the public and technicians, EDTA refers variety of salts (ethylenediaminetetracetates) that are used in application-specific formulations.  To a hard-core chemist, EDTA is an tetracarboxylic acid.  The folky approach is vague but useful to more readers, the chemical approach is rigorous but less interestint to readers. All forms are colourless and most are pretty insoluble in petroleum-based oils (of course the answer depends on the kind of oil).  It's not very toxic (although determined idiots will figure out ways of hurting themselves): oral LD50 value (rat) for Na2EDTA is 2.0 – 2.2 g/kg.  So you gotta eat a lot and contend with diarrhea.--Smokefoot (talk) 15:35, 21 February 2009 (UTC)
thread_title:  Physical properties? 

message: I am starting to edit this article, focusing mainly on converting lists to paragraphs.  But these sections look problematic:
"Widespread use of EDTA and its slow removal under many environmental conditions has led to its status as the most abundant anthropogenic compound in many European surface waters. River concentrations in Europe are reported as 10-100 μg/L, and lake concentrations are in the 1-10 μg/L range.  EDTA concentrations in U.S. groundwater receiving wastewater effluent discharge have been reported at 1-72 μg/L, and EDTA was found to be an effective tracer for effluent, with higher concentrations of EDTA corresponding to a greater percentage of reclaimed water in drinking water production wells.
EDTA is not degraded or removed during conventional wastewater treatment. However, an adjustment of pH and sludge residence time can result in almost complete mineralization of EDTA. A variety of microorganisms have been isolated from water, soils, sediments and sludges that are able to completely mineralize EDTA as a sole source of carbon, nitrogen and energy.
Recalcitrant chelating agents such as EDTA are an environmental concern predominantly because of their persistence and strong metal chelating properties. The presence of chelating agents in high concentrations in wastewaters and surface waters has the potential to remobilize heavy metals from river sediments and treated sludges, although low and environmentally relevant concentrations seem to have only a very minor influence on metal solubility. Low concentrations of chelating agents may either stimulate or decrease plankton or algae growth, while high concentrations always inhibit activity. Chelating agents are nontoxic to many forms of life on acute exposure; the effects of longer-term low-level exposure are unknown. EDTA at elevated concentrations is toxic to bacteria due to chelation of metals in the outer membrane. EDTA ingestion at high concentrations by mammals changes excretion of metals and can affect cell membrane permeability.
Other more biodegradable chelators are effective and available. For example, EDDS (S, S'-ethylenediaminedisuccinic acid) and NTA (nitrilotriacetic acid).
* EDTA played a role in the O.J. Simpson trial when one of the blood samples collected from Simpson's estate was found to contain traces of the compound. This was used by the defense to indicate that the sample had been planted from one of the vials collected during the investigation. Prosecution claimed EDTA might have appeared in the sample as a result of eating McDonald's foods (either through bloodstream or, more likely, via contamination of blood flowing over the hand used in grabbing the food)."
--Smokefoot (talk) 16:15, 21 February 2009 (UTC)
replies: text: It is highly unlikely that the blood on the sock in the OJ murder case was contaminated in an innocent fashion.  Yes, EDTA is present in food and laundry detergent, but at very low concentrations, and EDTA is very soluble in water.  (a washed sock might have an exceedingly tiny amount of EDTA on it, but far less than would have been caused by using blood collected in an EDTA-containing sample vial.) Whether the amount of EDTA normally present in a person's blood would show a significant concentration, I don't know.  The sample vials used to hold collected blood contain a gel at the bottom with EDTA included; the function of the EDTA is to chelate the magnesium ions present, and thus prevent the blood from clotting.  The police wouldn't have known this, and presumably thought they could undetectably incriminate OJ by taking blood from the sample OJ had given the police.  This was discussed during the trial.  Curiously, although EDTA was and is used in many analytical labs, they had to develop a specific quantitative test for it during the trial.   67.5.213.48 (talk) 18:01, 16 May 2016 (UTC)
thread_title: Edits

message: in the above article,Uses in Medicine,Last entry is Use in Thalassemia Major to remove excess iron.Pl.indicate the reference of source i.e journal etc.thanks  —Preceding unsigned comment added by 117.198.195.147 (talk) 12:59, 22 April 2009 (UTC)
thread_title:  wikipedia article on E.D.T.A.[ethylene diamine tetra acetic acid] 

message: Disodium edetate CAS no. [6381-92-6] has been added based on the following info
http://www.google.com/webhp?hl=en&tab=nw#hl=en&newwindow=1&q=Disodium+edetate+International+Pharmacopoeia+site%3Awww.who.int&aq=f&oq=&aqi=&fp=fNPyysaHsgc
--222.64.218.82 (talk) 02:33, 18 July 2009 (UTC)
thread_title:  A red link of .... 

message: I just edited the pKa values. Nevertheless, the values deserves a few comments:
The two lower values (0.0 and 1.5) are concidered less reliable according to my source (Harris, D.C. "Quantitative Chemical Analysis", 7th ed., W. H. Freeman and Compagny, New York, 2007). 
Another source (the Combined Chemical Directory 11.2, Taylor & Francis Group 2009) states the following values at 20 °C: 0.26; 0.96; 2.02; 2.66; 6.21 and 10.31 - all in 0.1 M KNO3. 
CLHA (talk) 15:54, 20 July 2009 (UTC)
replies: text: I added a sentence on this matter citing a different reference. --Leyo 12:02, 14 September 2018 (UTC)
thread_title:  pKa values 

message: The bond-line formula shown in the png at the upper right is missing the central double bond. "Enthylene" implies a double bond.  —Preceding unsigned comment added by 160.39.86.218 (talk) 14:47, 23 July 2009 (UTC)
replies: text: I believe "ethylene" in the non-IUPAC name referes to ethane missing two H atoms. "Ethylene" is not used in the IUPAC name. Analogous: methylene chloride (dichloromethane, CH2Cl2) contains no double bound but has two H atoms less than methane.]CLHA (talk) 14:47, 10 February 2010 (UTC)
thread_title:  Bond-Line Formula 

message: 2,2',2' ',2' ' '-(ethane-1,2-diylbis(azanetriyl))tetraacetic acid  -  ChemDraw
shorter than that one  — Preceding unsigned comment added by 194.8.130.174 (talk) 10:02, 30 March 2013 (UTC)
thread_title:  IUPAC name 

message: I read the article looking for information about EDTA as a food additive. I was looking for tinned Ful medames in the UK and every brand and recipe I looked at included EDTA as a food additive to help the beans retain their colour. The label stated 'EDTA, for colour retention'. The EU number for the calcium/sodium salt is E385. 82.38.135.178 (talk) 08:29, 28 March 2017 (UTC)
replies: text: I too would like to request more information on "calcium disodium EDTA" as used as a food additive. Can anyone expand the article? 2600:1000:BE0C:E14:999A:C84B:5CFA:BC27 (talk) 20:11, 7 August 2021 (UTC)
replies: text: Why is no one addressing this issue?  "Calcium disodium EDTA" (a very common food additive) is still mentioned nowhere in the text of this article, although this article redirects from Calcium disodium EDTA. Please fix this situation! 173.88.246.138 (talk) 02:15, 6 September 2021 (UTC)
thread_title:  Food additive 

message: To add to the above discussion, in the literature (see e.g my recent edit today) ethylenediaminetetraacetic acid disodium salt is also referred to as EDTA.  Should attention be drawn to this fact in the article's lede? LookingGlass (talk) 08:21, 14 April 2017 (UTC)
replies: text: Yes EDTA is the common name so support move. Doc James (talk · contribs · email) 01:15, 15 April 2017 (UTC)
replies: text: I'd support such a move as more friendly to a general readership (ie folks reading canned food labels and such rather than persons with a specialized interest in chemistry). To pull in a broad sampling of views on such, perhaps someone could open a general RfC to discuss whether a page move should be formally proposed again. --75.188.199.98 (talk) 07:50, 5 November 2017 (UTC)
replies: text: p.s.— FWIW, WP:TECHNICAL leads with, , and, . 'WP:ASTONISH' might be worthy of some consideration in this as well (what usage is inspiring most readers to seek out information here in the first place?). --75.188.199.98 (talk) 07:50, 5 November 2017 (UTC)

text: Ya' know,  (WP:EXPLAINLEAD), probably has relevance here as well. --75.188.199.98 (talk) 08:00, 5 November 2017 (UTC)
thread_title:  REVISITED : Requested move: Ethylenediaminetetraacetic acid → EDTA 

message: With respect to this text
"Non-curative minimal reversal of atherosclerosis has been claimed by therapies with iv ethylenediaminetetraacetic acid disodium salt (EDTA). EDTA has been combined with antibiotic tetracycline (comET) and has been tested with respect to infectious blood nanobacteria in therapy in patients with documented coronary artery disease (CAD). Coronary artery calcium scores decreased during ComET therapy trial in most CAD patients inferring regression of calcified coronary artery plaque volume."
This is supported by a small primary source. We need high quality secondary sources per WP:MEDRS. Doc James (talk · contribs · email) 01:15, 15 April 2017 (UTC)
replies: text: Has been restored. However extra ordinary claims do require extra ordinary evidence. Doc James (talk · contribs · email) 16:10, 16 April 2017 (UTC)

text: The text you cite here, and insist on deleting, is, as you will see, comprised of two parts.  The first part states: "Non-curative minimal reversal of atherosclerosis has been claimed".  The second part states: "EDTA has been combined with antibiotic tetracycline and has been tested with respect to infectious blood nanobacteria".  So, assuming your objection is substantive and not merely pedantic, are you saying there has been no work with EDTA and atherosclerosis/nanobacteria or that merely better references to this fact are required?  In both cases however the primary point I am making is that there are OTHER medical uses/relevance/application of EDTA to those cited in the article and which you appear to insist remain exclusive cited as the ONLY uses/potential uses/investigated uses of the substance. My intrest is with EDTA so with the fact of its test/investigations/research as distinct to its use by the medical profession.  I am not interested in a wiki rewrite of MedOnline or whatever but of a wikipedia article on EDTA. I hope this clarifies. p.s I have taken the liberty of deleting the < ref > code from the citation you pasted here as it breaks the flow of the page appearing as it does at the bottom of ALL the comments here rather than just this one to which it solely applies. If you wish to add it back please simply rtemove the code when doing so. I have also edited the subject line of this comment so as to make it specific to the matter at hand i.e the deletion of the text rather than its addition.  Adding text is merely the lifeblood of wiki.  Deleting text is something else.  Thank you.LookingGlass (talk) 12:10, 19 April 2017 (UTC)
replies: text:  Re: "p.s" ... , , for-future-reference the  template (or one of its many redirects) may prove useful in handling such going forward. --75.188.199.98 (talk) 07:16, 5 November 2017 (UTC)
replies: text:  Noticed stray numbered ref link at bottom of page; implementing . --A Fellow Editor (talk) 18:27, 25 November 2017 (UTC)
replies: text: Know what I mean !?! Thanks. LookingGlass (talk) 11:48, 17 December 2017 (UTC)
thread_title: Text deletion

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*Added archive https://web.archive.org/web/20061029103725/http://www.chem.utk.edu/~chem319/Experiments/Exp6.pdf to http://www.chem.utk.edu/~chem319/Experiments/Exp6.pdf
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thread_title:  External links modified 

message: The initial instances of the terms disodium EDTA and calcium disodium EDTA have been boldfaced as redirect target terms (i.e. as terms in an article or section targeted by redirect pages; e.g.  and )—a practice recommended by WP:R#ASTONISH, Wikipedia:Manual of Style/Text formatting#Other uses, and MOS:BOLD#Article title terms—so as to help orient readers arriving from redirect links elsewhere and as an example of best practice inline with Wikipedia policy and guidelines.
Thanks for your time and attention, --A Fellow Editor (talk) 18:22, 25 November 2017 (UTC)
thread_title:  Boldfacing of redirect targets 

message: Are you sure about Cr, I think it is another element
--the good K--
— Preceding unsigned comment added by 46.189.28.44 (talk) 14:47, 12 February 2018‎ (UTC)
:Yes. The cited ref at the next sentence (talkign about the usefulness of the method) supports it. DMacks (talk) 12:46, 26 June 2018 (UTC)
thread_title:  item 

message: The following Wikimedia Commons file used on this page has been nominated for deletion:
* 
Participate in the deletion discussion at the . —Community Tech bot (talk) 14:51, 15 November 2019 (UTC)
thread_title:  A Commons file used on this page has been nominated for deletion 

message: https://www.sciencedirect.com/science/article/pii/S0306987720312007
Medical Hypotheses
Volume 144, November 2020, 110027
Title: Why the lower reported prevalence of asthma in patients diagnosed with COVID-19 validates repurposing EDTA solutions to prevent and manage treat COVID-19 disease
--ee1518 (talk) 11:32, 14 October 2020 (UTC)
thread_title:  Hypothesis: EDTA might prevent covid-19 

message: I removed this sentence from the alternative medicine section: “Although, U.S. medical associations — including the American College for Advancement in Medicine (ACAM) are dedicated to training doctors in the use of chelation therapy to improve hardening of the arteries and other chronic degenerative issues.” The justification for removal is that not only is the material is unsourced, it also implies that chelation therapy is effective against cardiovascular disease by saying that “U.S. medical associations” are training doctors in chelation therapy. Using the term “U.S. medical association” alone when referring to the ACAM, although true, is possibly deceptive because it implies that the ACAM is close to the medical establishment and likely a respected institution, without providing much information about it.  In terms of how respected it is, it doesn’t appear to have a Wikipedia page, but here’s some text from the page Chelation therapy: 
“In 1998, the U.S. Federal Trade Commission (FTC) charged that the web site of the American College for Advancement in Medicine (ACAM) and a brochure they published had made false or unsubstantiated claims. In December 1998, the FTC announced that it had secured a consent agreement barring ACAM from making unsubstantiated advertising claims that chelation therapy is effective against atherosclerosis or any other disease of the circulatory system.” 
Also on that page: “According to the findings of a 1997 systematic review, EDTA chelation therapy is not effective as a treatment for coronary artery disease and this use is not approved in the United States by the US Food and Drug Administration (FDA).” Notably, that page also contains a pro- ACAM paragraph, but given the preponderance of well- cited material on that page against chelation therapy, that paragraph seems less like a counterpoint than evidence that proponents of chelation therapy as a method to treat cardiovascular disease have added deceptive material to several Wikipedia pages.
The reason I wrote this whole paragraph was to have a solid bulwark to stand on to explain this removal, both so that bystander editors will understand why this sentence was removed, and, more importantly, as a defense should the pseudosciencechelationists, who appear to have some real power on Wikipedia, challenge this edit and attempt to restore either the original sentence or some more well- disguised version. MaroonDichotomy (talk) 07:56, 3 September 2022 (UTC)
thread_title:  ‘Alternative medicine’ edit explanation 

message: ronitkumar079035@gmail 157.47.15.9 (talk) 15:49, 29 December 2022 (UTC)
replies: text: Is there any research on Effects of EDTA on treatment of Multiple System Atrophy (MSA) disease? Iron sedimentation and aggregation in glial cells of cerebellum and brain stem is probable ethiology of this disorder. Study effects of ATH434 on MSA is recruited in some hospitals now. Parsman~fawiki (talk) 14:02, 2 September 2023 (UTC)
thread_title:  Edta 

message: Recently slug pellets using iron phosphate and EDTA have come onto the market, the claimed mechanism is the chelating agent causes the otherwise insoluble iron ions to kill slugs that ingest them from iron poisoning. 
Perhaps someone could write a bit under uses for this. 90.247.227.132 (talk) 18:37, 30 April 2023 (UTC)
thread_title:  Use as pesticide