Talk:Denise Faustman

message: EDITS UNDER 'RESEARCH'
Re: Edit in paragraph beginning with "Former Chrysler chairman Lee Iacocca..." in which the clause, "[JDRF] whose reviewers raised serious issues about the proposed work" was deleted:
:A. I do not think that JDRF reviewers' comments are publicly available. If not, then I do not see how this statement, that the reviewers raised 'serious issues,' can be verified. 
:B. JDRF and Faustman issued a joint statement in two letters on April 8, 2005 about the fact that JDRF did not provide funding for her to pursue the type 1 diabetes "cure" work. Please see: http://www.jdrf.org/index.cfm?page_id=103404. Peter van Etten of JDRF writes, "The research application by Dr. Faustman and Dr. David Nathan was one of many regeneration proposals the JDRF reviewed last year. It was also one of many that we chose not to fund. That decision reflects the judgment of our review boards on one particular research project; it does not reflect a change in JDRF’s significant focus on, or ongoing support for, regeneration science. Dr. Nathan and Dr. Faustman’s request to JDRF was for only a fraction of the funds necessary to initiate her clinical trials."
Re: Edits on BCG:
:A. BCG is used a certain doses as a preventive tuberculosis vaccine; at other doses it is used in the treatment of bladder cancer. See: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682809.html
:B. Faustman is building equipment in her lab that she hopes can help her evaluate what dose, if any, of BCG might be therapeutic. 
EDITS UNDER 'THE DEBATE/COMMUNITY RESPONSE'
Re: Comments by previous poster (above) and Previous removal of the statement that "Giving Freund's adjuvant alone has been known to cure type 1 diabetes in NOD mice for many years":
:A. While Freund's adjuvant (CFA) (along with numerous other interventions), has been know to "cure" NOD mice, these were only early stage/pre-diabetic mice, not end-stage mice. Frend’s adjuvant when administered to hyperglycemic mice can stall the disease, but is not a cure (no permanent elimination of disease, i.e., no T cells in the pancreas, no disease transfer and no chance of disease recurrence). In Faustman's work, CFA + spleen cells matched for MHC class I and self peptide was beneficial in end-stage (hyperglycemic) mice. This was part of what was novel, in addition to the fact that she saw regeneration of the islets. 
:B. As with much research, Faustman's concepts have yet to be proven in humans. Previous poster speaks about "Faustman's failure." From all of the available data, it seems that her apprach is very much under debate and is at the center of a lot of politics, but I don't yet see any failure. In fact, a review of the abstracts being presented at the American Diabetes Scientific Sessions June 2006 shows that a group from the National Institutes of Health (NIH) (Tran et al. Poster 1202-P) has in fact replicated her work--including halting type 1 diabetes and another autoimmune disease (Sjogren's syndrome) in an NOD model, as well as noting a contribution from a splenic stem cell. Overall, I would argue that it is really too early to draw any conclusions or try to discredit this research.
:C. Previous poster talks about NYTimes (Byline: Gina Kolata) "mischaracterizing" the research. The Wall Street Journal (Byline: Sharon Begley) ran a similar article as the NYTimes. The Science article the previous poster refers to (Byline: Jennifer Couzin) is, similarly, a newspiece run in Science, not a peer reviewed paper. (The three papers from the JDRF-funded labs that ran on March 24, 2006, when all of the above mentioned articles ran, were peer-reviewed). I think it would be a fair, NPOV conclusion to say that the different angles seen in these stories reflect the wider debate over this research in the academic community. I do agree to keep in the quotes from Science that above poster has suggested. 
Using the word "Mischaracterizing" is really not NPOV.
Caravass 16:15, 24 May 2006 (UTC)
thread_title:  Edits by Caravass May 25, 2006 

message: This article in its current form does not remotely match the standard presentation for WP biographies. The external link section contain material some of which  should go as references, and some that should be removed. The research section is devoted to the detailed presentation of a current project, rather than a general summary.  In particular, we do not normally emphasize the potential clinical applications of results that are still in the preclinical or early trial stage, or discuss the importance of the medical problem.   Every biomedical scientist at least hopes for practical clinical application, just as every entrepreneur hopes for a wildly successful business. Once they have become practical and successful, then they're appropriate to discuss here.   WP pages are not written to say what the subject would like to have the public know, or to impress readers about the possibilities of the subject's work; that is considered promotional -- rather, WP articles are written to give the information the general public who have heard of the subject might want to know. I'll take a look for rewriting.  DGG ( talk ) 23:34, 28 February 2019 (UTC)
thread_title: non-standard