Talk:Retinol

message: Vitamin A is stored in hepatic stellate cells, not in hepatocytes.  — Preceding unsigned comment added by 184.56.240.162 (talk) 14:17, 20 January 2015 (UTC)
thread_title:  Storage 

message: Is retinol pronounced the same as retinal?   Or does the latter rhyme with 'pal' while the former rhymes with 'all'?   Are these two words treated as homonyms for the most part?   Dexter Nextnumber (talk) 06:30, 25 June 2010 (UTC)
thread_title:  Pronunciation 

message: According to an article at http://www.westonaprice.org/healthissues/supplements.html, vitamin A overdose did not kill any explorers:
:The warnings against vitamin A usually include mention of Arctic explorers who died from vitamin A overdose because they consumed polar bear livers. Actually, the early explorers did not die from eating polar bear liver. They did suffer from exfoliative dermatitis and hair loss. In 1988, a team of Swedish scientists discovered that polar bear and seal livers tend to accumulate the metal cadmium. The symptoms for cadmium poisoning are exfoliative dermatitis and hair loss, but don't expect to hear about this on the evening news. Rather, expect continuing stories about the alleged dangers of vitamins A and D. The media and the medical establishment work together to vilify the very substances that can prevent suffering and disease.
Unfortunately it contains no references. The same information is used at (defunct) www.cureamerica.net/medicalfreedom.htm:
:Another vitamin that Americans have been caused to become concerned about is vitamin-A.  Its ridiculously low RDA is 5000 I.U..  A person eating a modest meal of carrots and liver consumes at least 100,000 I.U. of vitamin-A, and he does it without a doctor's prescription, and each spoonful is in violation of the RDA's.  Spinach, sweet peas, potatoes, red peppers and dried apricots would also be disallowed from the doctor's prescription if the FDA ever is allowed to enforce the RDAs. In February 2001, UNICEF reported that a program that began in 1988 giving high-dose capsules of vitamin-A to strengthen the body's immune system has averted one million child deaths.   If  vitamin-A is so abundant in common food then how could the medical authorities convince the doctors to warn the public about the dangers of taking too much and that it could be poisonous ? The answer most frequently cited is that eating polar bear livers, which contain as much as 8,000,000 I.U. of vitamin-A, was fatal for the early arctic explorers.  My God !  When was the last time that you ate polar bear liver ?  The tragedy behind this ridiculous stance is that it is based on misinformation.  To begin with, the early explorers did not die from eating the polar bear liver which was so delicious that they devoured large amounts at each meal,  but rather became sick, suffering from dermatitis and defoliation. Then, ironically, in the late 1980's, a team of Swedish scientists discovered that polar bear liver adsorbs large amounts of cadmium metal found in the arctic water.  The symptoms of cadmium metal poisoning are  dermatitis and defoliation.  Thus, the ailments of the early explorers were caused by the cadmium in the polar bear liver, and not the large amount of vitaminn-A.   The tragedy is that despite the scientific evidence, "too much" vitamin-A  still remains "toxic" in the doctors minds.
But again, no references.
-rfr
: I see no reason to lend any of this credence.  —Casey J. Morris 07:39, July 22, 2005 (UTC)
:: What reason do you have to lend credence to the point of view they're arguing against, other than the fact that you've been preconditioned with it? --81.181.165.163 13:18, 18 October 2005 (UTC)
replies: text:  That article deliberately mixes and confuses carotenes with retinoids. They are NOT the same thing. Much of the 'vitamin A' in a carrot and liver meal is carotenes, but carotenes aren't really toxic. On the other hand there are concerns about eating a lot of liver, because it does contain significant retinoids.WolfKeeper 16:31, 30 December 2005 (UTC)

text: Okay, I've also added a short paragraph to express this.
The Dr. Mercola article can no longer be found. In addition, he has been cited by the FDA for making false claims before. He really should not be considered a reliable source.  — Preceding unsigned comment added by Angmar09 (talk • contribs) 17:23, 30 October 2011 (UTC)
thread_title: More recent posts not placed under the older one 

message: In 2003-4 about thirty children died in North East India after an overdose of Vitamin  A drops, raising concerns about the programme.  Will try to get references soon.
:http://www.flonnet.com/fl1903/19030830.htm
:"One of the suspected causes for the deaths was the unilateral switch by UNICEF to the use of a 5 ml dispenser. The Government of India's stated norm is a 2 ml dose. The dispensing health workers were reportedly not warned of this or trained adequately. The Report, however, takes cognisance of the fact that a change in methods of dispensing in some areas might have resulted in the administration of a higher dose and that some children may have suffered side effects due to the plastic cup measuring out a mega dose."
--143.182.124.1 23:08, 29 December 2005 (UTC)
thread_title: UNICEF's EXPERINCE WITH VITAMIN A OVERDOSE IN INDIA

message: Don't know if this proves anything, just throwing it in there.
--143.182.124.1 23:09, 29 December 2005 (UTC)
thread_title:  Source for cadmium buildup in polar bear livers... 

message: Does anyone have a link to an article or a website that has full retinol synthesis scheme?
What enzyme or pathway is responsible for the cleavage of beta-cartene into retinol?  —Preceding unsigned comment added by 216.9.143.231 (talk) 04:38, 23 November 2010 (UTC)
thread_title:  Full retinol synthesis 

message: :Vitamin A affects the production of human growth hormone.
How exactly? It inhibits it? Promotes it? Does it affect its synthesis, or does it attack it once it is made? Does it affect the enzymes used to synthesis it? How? Is it a competitive inhibitor or non-competitive? Or a co-enzyme, or even a substrate? This has to be one of the most amibiguous sentences i've come across on wikipedia. Which is especially bad as it seems it may describe a rather important process. Someone fix it, and get a source too - mastodon 23:05, 1 May 2006 (UTC)
thread_title:  growth hormone 

message: What's with the fat-man factor-A reference? Is that a joke, a piece of disinformation? Should it be removed?
:I've removed it for now.  If someone can find a reference for it, it can be added back in. --Ed (Edgar181) 12:26, 7 May 2006 (UTC)
thread_title:  Fat-man factor-A 

message: I read about the potential for eliminating acne in a very small, local magazine (which has since been thrown out), and it said that dietary supplements, ie daily vitamin tabs, could also fight acne, not just the topical ones. So I started taking a Vitamin A and D mixture I got at the grocery store, and sure enough, it works. Someone might want to emphasize that it is not necessarily just topical.
I wish I had that article..... (it cited a "recent" research study in the area. I don't know what "recent" means in terms of medicine)
:You probably don't want to mess with that. Retinyl parmitate (and isotretinoin) are both fairly toxic in the doses needed to deal with acne and require medical checks and advice to undertake safely.WolfKeeper 20:58, 10 July 2006 (UTC)
replies: text: Is this also true of topical application of retinol on the skin?   Is it dangerous to the skin, or does it get passed further into the system if it is applied topically?   What about people who have acne in and around the ears, or just inside the edge of the nose, or on the eyelids, shoulders, scalp, armpits, and the pits of the elbows?   In the United States, is retinol a controlled substance, and subject to seizure by Federal authorities?   If it is dangerous, how dangerous?   Are there any studies that can be cited in the main page of this article?  Dexter Nextnumber (talk) 09:49, 23 June 2010 (UTC)
thread_title:  Usage Against Acne 

message: I added a list of synthetic source trade names.  They are all available from the FDA's lists of approved drugs; however I got the original list from http://www.innvista.com/health/nutrition/vitamins/a.htm.  Lists are not subject to copyright in the U.S. under Feist Publications, Inc. v. Rural Telephone Service Co., 499 U.S. 340
--Selket 06:05, 21 January 2007 (UTC)
thread_title:  Synthetic Sources 

message: I followed the link to the reference "Stone, Brad. Vitamin A and Birth Defects, 6 October 1995, retrieved 20 June 2007" and discovered that this does not appear to be the high-quality sort of source that you would expect to be used in an encyclopedia.  It bases its information on "the forthcoming New England Journal of Medicine article" but does not even say what article this is.  I believe this is the same famous 1995 piece by Rothman, et. al. on which nearly every subsequent warning about retinol has been based.  In my understanding, the conclusions of the Rothman piece do not support the recommendations made in reference 6, and especially not the extreme statement made here that references 6:
:Even twice the daily recommended amount can cause severe birth defects.[6]
This erroneous statement needs to be changed, and whatever replaces it needs to be based on a careful reading of the Rothman NEJM 1995 article. Neoprote (talk) 10:45, 29 May 2008 (UTC)
thread_title:  Reference number 6 

message: It is confused me that i find 2 kind of CAS No.11103-57-4 and 68-26-8 of which the structures are same.And what confuse me more is that it is different between the english vision and chinese vision of the same article. And i can only seach CAS No. of 68-26-8 in sigma-aldrich.i donot know which one is the corrected one.116.227.44.205 (talk) 15:45, 17 November 2008 (UTC)
thread_title:  about CAS No. 

message: The article states that Retinol is the "animal form of vitamin A" is this correct? I do not understand animal form, is it supposed to say "Acid form" instead? 
DiscoElf (talk) 14:38, 19 October 2009 (UTC)
replies: text: No, it's supposed to say "animal form", as opposed to vitamin A from plant sources, which are carotenoids.  Whether this phrase is a good way of expressing that is another question, of course.  Do you have an alternative suggestion? --Trovatore (talk) 20:56, 19 October 2009 (UTC)
thread_title:  Animal Form? 

message: I hadn't looked at this article for a while, and it appears to me that a great deal of material is creeping in that would be better handled at vitamin A.  The whole reason for having two separate articles is that vitamin A comprises quite a few different molecules (arguably including carotenoids, which are referred to as pro-vitamin A by some sources, but just vitamin A by others).  On the other hand, retinol is one specific chemical.
So I think the retinol article should be primarily about retinol's chemical properties.  If there are physiologic properties specific to retinol, as opposed to other forms of vitamin A, then I suppose those are also reasonable to treat here.  But material about the physiological effects of vitamin A in general, as opposed to retinol specifically, should be moved to vitamin A. --Trovatore (talk) 23:45, 11 December 2009 (UTC)
replies: text: I just came here to make the exact same comment. Glad you agree! I'll move some stuff about vitamin A vitamers other than retinol to the vitamin A article, leaving one-line summaries and main article redirects behind. SBHarris 23:48, 21 July 2010 (UTC)
thread_title:  Much material should be moved to [[vitamin A]] 

message: Not a single mention of it's use/overuse in practically every product in the cosmetics industry related to skin care... really, nothing?  — Preceding unsigned comment added by 220.240.223.126 (talk) 14:14, 25 November 2020 (UTC)
replies: text: See Retinol skin treatments, above. David notMD (talk) 09:07, 21 January 2022 (UTC)
thread_title:  Cosmetics 

message: — Assignment last updated by Xc1181 (talk) 21:01, 21 April 2024 (UTC)
thread_title: Wiki Education assignment: Research Process and Methodology - SP24 - Sect 201 - Thu