Talk:Adrenoleukodystrophy

message: This was reviewed in a JAMA update. JFW | T@lk 00:50, 1 January 2006 (UTC)
thread_title:  JAMA 

message: I have removed the references to cocaine which were entirely unsourced and unsupported by medical science. I have also removed the hurtful reference to Lorenzo's death. This surely violates Wiki principles on mention of living people. I hope whoever put it in feels ashamed of themselves for the upset this has caused to his family. He is alive and living in Fairfax Virginia. Edwardlucas 17:52, 21 July 2007 (UTC)
replies: text: see also  as reference for Lorenzo being alive today. Felsir 20:49, 22 July 2007 (UTC)
thread_title:  Cocaine 

message: Under the Symptoms section, one sentence reads: 
The most severe type is the childhood cerebral form for most likely the male, which normally occurs between the ages of 4 and 10 and is characterized by failure to develop, seizures, ataxia, adrenal insufficiency, as well as degeneration of visual and auditory function.
The sentence is a little oddly worded.  Failure to develop what, exactly?  It could also be misconstrued as saying the individual who had this disorder has a failure to develop seizures, etc.  —Preceding unsigned comment added by 65.67.115.63 (talk) 18:50, 31 May 2008 (UTC)
replies: text: Done.  If it were up to me, I'd replace the section on Lorenzo Odone with one on Hugo Moser.  The usefulness of Lorenzo's oil, if any, remains to be proven, which is why studies are still being done. Pustelnik (talk) 01:09, 8 July 2008 (UTC)
thread_title:  Minor Critique 

message: It must be noted how, despite the profusion of descriptions of mechanisms of action and symptoms, there are very few good sources. I must also call into question the overall quality of the English in this article - especially in a few sections such as this one:
:===Cause===
:Slowly by stripping the myelin sheath (a protective sheath on your nerves in your brain) :the affected person would slowly begin to loose body function and eventually will not be :able to talk. There is a over load of long chain fatty acids that ones body cannot :dispose of. This does not follow the basic unit of life. (Everything one takes in must :be able to be disposed of as waste) This over load of fatty acids will build up in your :brain and that is what strips the Myelin Sheath.
Note the complete lack of citations where needed, unlinked text, questionable use of English and the direct derivation from the movie Lorenzo's Oil (an unreliable source, to say the least). There are several more examples dotted throughout the article.
Finally, I would like to suggest that the "summary" be split up and merged with the various sections in the body - as is, it is comparable in length of the article itself.
--83.183.127.178 (talk) 02:28, 21 November 2011 (UTC)
thread_title:  Concerns regarding article quality 

message: According to a Washington Post article:http://www.washingtonpost.com/wp-dyn/content/article/2007/01/27/AR2007012701542.html
Dr. Hugo Moser developed a test for early detection 
of ALD. The article says that he died before his test 
could be validated and that the specimens for the 
test were very rare and great pains were being taken 
to make the test as accurate as possible since no more 
specimens were available.  
— Preceding unsigned comment added by Benvhoff (talk • contribs) 23:49, 5 March 2013 (UTC)
thread_title:  Did Dr. Hugo Moser's test for early detection of ALD prove successful? 

message: Just working with a 1st semester Biochemistry background, I have to question the lack of focus on the carbohydrate and hydrogenated fat aspects. It has been long known from what is called the "Soft Pork Problem" that feeding a high-carbohydrate diet of corn to hogs made for hard fat (highly saturated, long chain fats) rather than soft fat that came from feeding peanuts to the hogs.  Fructose is a major sugar in corn, so elimination of that from the diet should be key. Excess carbohydrates in general are going to be stored as fat. It is also known that the nature of fats(melting point evidence) stored in the body of animals can be changed with a change in type of fats ingested. Hydrogenated vegetable oils are already solid when they enter the body, so they would add a long chain saturated fat burden to the problem.  
Source of "Soft Pork Problem" is Biochemistry 8th edition (1970) by Orten and Neuhaus, page 322.   — Preceding unsigned comment added by 172.78.56.88 (talk) 21:07, 3 February 2017 (UTC)
thread_title:  Questions on Dietary Therapy 

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thread_title:  External links modified