Talk:Chlortalidone

message: There seems to be some question over Chlorthalidone vs. Chlortalidone. The gent who forwarded Chlorthalidone to Chlortalidone indicated that the former was the spelling used in the UK until it was changed to the latter. My research seems to indicate something different. According to the Novartis web site, Chlorthalidone is a Thiazide-based diuretic (that is NOT marketed in the UK according to Novartis #1) and Chlortalidone appears to be a Sulfonamide-based diuretic marketed by Sandoz. Perhaps the spelling was changed in the UK because of the product difference between Novartis and Sandoz. I don't know so I have written to both manufacturers requesting clarification of the terms and usages. I will update these articles when I have more information: Hygroton, Chlorthalidone, and Chlortalidone. JimScott 01:46, 16 January 2007 (UTC)
replies: text: Chlortalidone and chlorthalidone are, in fact, one and the same. Chlorthalidone was the British Approved Name (i.e., the name used in the UK) until 2004, when it was changed to the International Nonproprietary Name chlortalidone. (see this link) Unfortunately, to make matters worse, chlorthalidone is still the United States Adopted Name (i.e., the name used in the U.S.) According to Wikipedia's convention on naming of drug pages, articles should be named according to the INN whenever possible, hence the move to chlortalidone. Feel free to expand the article though, it's still only a tiny stub. Fvasconcellos 02:06, 16 January 2007 (UTC)
thread_title: Chlort<u>h</u>alidone vs. Chlortalidone

message: I reverted an edit that removed much of the lay language in the first sentence of the lede.Sbelknap (talk) 19:03, 31 October 2018 (UTC)
thread_title: lay language

message: We need to add a pharmacokinetics section, as the longer half-life of chlortalidone is highly relevant to its superior efficacy compared to HCTZ. I will put together a draft over the next few days. Sbelknap (talk) 19:13, 31 October 2018 (UTC)
thread_title: pharmacokinetics

message: And now that some do not we need to attribute this.
Doc James (talk · contribs · email) 20:19, 19 February 2020 (UTC)
replies: text: We have a summary of this trial by the ACC here. I am sure we will hear more soon as this gets combined into position statements and reviews. Doc James (talk · contribs · email) 20:25, 19 February 2020 (UTC)
replies: text: The best available evidence is the meta-analysis of the nine clinical trials that directly compared chlortalidone and hydrochlorothiazide, so I've added that to the adverse effect section. Sbelknap (talk) 22:52, 24 March 2020 (UTC)
thread_title: Only some recommend over [[HCTZ]]

message: *
Is small. Not listed as a review. And is from 2000. Doc James (talk · contribs · email) 23:44, 25 March 2020 (UTC)
replies: text: Okay for the body of the text. Doc James (talk · contribs · email) 23:45, 25 March 2020 (UTC)
thread_title: Not a great study

message: Ref says "Thiazide-like diuretics have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia." not seeing the 20% Doc James (talk · contribs · email) 20:00, 28 March 2020 (UTC)
thread_title: Magnesium