Talk:Monoamine oxidase inhibitor

message: Hello, I absolutely believe what's being said; but would like a source. I know its verifiability self-evident to an extent, but consider perhaps putting (or at least hooking me up with) a citation for the last sentence of the first section stating: "RIMAs have not gained widespread market share in the United States."
I know this is not a top priority, but I think this claim should cite a source. IMHO.  — Preceding unsigned comment added by -.+ThAYYta+.- (talk • contribs) 19:06, 10 October 2023 (UTC)
thread_title:  I have ONE (1) question. I believe the claim on its face, but I'd like a source. Re: First section 

message: Removed the mention of DXM potentiation. AFAIK, this combination is extremely dangerous/lethal, and I have never heard of any potentiation of the desired effects. Correct me if I'm wrong :) --unsigned comment
You are most definitely NOT wrong. That combination has killed, with a not very large dose of DXM taken after Nardil. See http://www.inchem.org/documents/pims/pharm/pim179.htm#PartTitle:11.%20ILLUSTRATIVE%20CASES. I added DXM to the list of bad interactions. --Frank Lofaro Jr. 23:26, 4 January 2007 (UTC)
thread_title:  DXM 

message: Some information should be added on the dangers and potentially lethal effects of combining MAOIs with these substances. Seretonin syndrome has occured, and been lethal when people have combined MAOIs with MDMA to either 'potentiate' the experience, with ignorance to the dangers (prescribed without education) or through adulteration.
See my addition, it addresses some of the points above which are a bit short on evidence base. Also see my additions to serotonin toxicity, serotonin syndrome, which answer the interaction issues with extensive references. But yes, MDMA with any MAOI is definitely risky, a short route to enriching undertakers. And yes, we need more headings and organisation. Perhaps someone can digest my extensive addition and suggest where to go from there, does the diet bit need moving? For those interested there is more information on my web site Ken Gillman 10:07, 24 September 2006 (UTC)
thread_title:  MDMA, DXM etc. 

message: i have added an unsourced banner due to lack of sources.
hopefully enough people visit this page for it to have an effect.
....[goes off source hunting]Dylan2106 22:30, 28 March 2007 (UTC)
thread_title:  Unsourced 

message: Tobacco contains Harmal, a powerful monoamine oxidase inhibitors (MAOIs)
monoamine oxidase inhibitors (MAOIs)+tyramine =cheese syndrome
 
monoamine oxidase inhibitors (MAOIs)+ tryptophan=hyperserotonemia
Tyramine =foods that went through fermentation or decay.
Foods containing considerable amounts of tyramine include fish, chocolate, alcoholic beverages, and fermented foods such as cheese, soy sauce and soy bean condiments, sauerkraut, processed meat, and red wine.
Tryptophan =chocolate, oats, bananas, dried dates, milk, yogurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, sunflower seeds, pumpkin seeds,spirulina and peanuts. It is found in turkey at a level typical of poultry in general.
List of foods containing tyramine
hum...since there are a lot of smokers, shouldn't there be a warning somewhere since these two syndromes are potentially lethal!!!
--Wxyrty 21:29, 8 May 2007 (UTC)
replies: text: If the levels of harmal in cigarrette smoke were high enough to cause an interaction, then smoking would be an effective antidepressant, which it is not. 88.105.156.188 13:41, 18 May 2007 (UTC)
replies: text:  This list of interactions appears to be based on outdated information.  Practically all of the interactions you listed are not substantiated (no case reports and no reliable measurements of high tyramine levels; regarding tryptophan, only supplements are considered dangerous, generating frequent reactions), including: fish, chocolate, alcoholic drinks (except for draft beer and certain bottled beers - I will elaborate if you like), red wine, meat/fish (except if aged or spoiled), and all of the tryptophan-containing foods.  Cheese is only a problem if it is aged; nowadays most cheeses are processed. 174.111.242.35 (talk) 08:08, 17 May 2011 (UTC)
thread_title:  Shouldn't there be a warning? 

message: Are Monoamine oxidase inhibitors the only kind of oxidase inhibitor? That is, when someone uses the term "oxidase inhibitor," do they mean all and only the set of Monoamine oxidase inhibitors? Ling.Nut 13:46, 28 July 2007 (UTC)
replies: text: Aha, never mind... thanks... Ling.Nut 13:51, 28 July 2007 (UTC)

text: Amphetamine and methamphetamine are not MAOIs, so "they" probably don't talk about it because it isn't relevant whatsoever.  --A Shortfall Of Gravitas (talk) 23:23, 2 April 2020 (UTC)
thread_title:  aka oxidase inhibitor? 

message: In the bottom (REFERENCES)
BLTC Research [1] (2006). "Rasagiline: a neuroprotective smart drug?". The Good Drug Guide. Retrieved on 2007-12-02. “At dosages above around 2 mg per day, rasagiline loses its selectivity for MAO type B and also inhibits MAO type A. An MAO-B selective regimen does not cause significant tyramine potentiation, the dreaded 'cheese effect' common to users of older unselective and irreversible MAOIs who eat tyramine-rich foods. Thus low-dosage rasagiline demands no special dietary restrictions.”
The "Rasagiline: a neuroprotective smart drug?" link go to ENP, a online pharmacy broker... I think it should be removed.  —Preceding unsigned comment added by 85.80.193.230 (talk) 21:38, 31 July 2008 (UTC)
thread_title:  Seriously, WIKIPEDIA is linking to drug buying sites 

message: It would be very helpful to include an indication of what drugs among this class are in actual approved clinical use, in the English-speaking countries.  Readers could then more easily identify those specific articles    DGG ( talk ) 18:56, 19 December 2009 (UTC)
thread_title: need for mention of drug clinically

message: Just a note.  The MAOI dietary restriction is still in effect for the Emsam patch if prescribed at doses higher than 6 mg.  From the prescribing information:
"EMSAM is an irreversible MAO inhibitor. As a class, these compounds have been associated with hypertensive crises caused by
the ingestion of foods containing high amounts of tyramine. In its entirety, the data for EMSAM 6 mg/24 hours support the recommendation
that a modified diet is not required at this dose. Due to the more limited data available for EMSAM 9 mg/24 hours
and 12 mg/24 hours, patients receiving these doses should follow Dietary Modifications Required for Patients Taking EMSAM
9 mg/24 hours and 12 mg/24 hours. (See WARNINGS and PRECAUTIONS, Drug Interactions, Tyramine.)"
- http://www.emsam.com/
If someone does not follow the Emsam link they may not see that information at the other article and may miss this information.  Perhaps it would be helpful to add something like: "Dietary modifications for the lowest 6 mg dose is not necessary.  MAOI food restrictions are still required for the 9 mg and 12 mg patches."   
Prescribing information: http://www.emsam.com/ 
Distributor product page: http://www.dey.com/products/ M MED11 (talk) 17:14, 18 July 2010 (UTC)
thread_title:  Emsam Dietary Restriction 

message: Piperine is both a MAO-A and MAO-B inhibitor. http://www.ncbi.nlm.nih.gov/pubmed/15997146  —Preceding unsigned comment added by 70.248.192.104 (talk) 21:34, 30 November 2010 (UTC)
thread_title:  Piperine is not MAO-B selective. 

message: Hyperserotonemia can occur without the ingestion of foods containing tryptophan.  I know this to be true based on personal experience and I think it is irresponsible to suggest that serotonin toxicity occurs only when tryptophan is ingested.  It should instead be noted that serotonin is a neurotransmitter derived from tryptophan, and that eating foods containing tryptophan can increase the likelihood of the syndrome occurring and/or accentuate the problem.
Also, Serotonin Toxicity or Serotonin Toxidrome are phrases which emphasize that it is a form of poisoning and give the reader an idea of the severity of the syndrome.  The term "hyperserotonemia" suggests only an excess of serotonin and that it is a condition of the blood.  As many people associate serotonin only or mostly with positive emotions, this could be misleading for readers who do not fully understand the function of serotonin or the dangers of extreme amounts it.
www.psychotropical.com is the website of one of the leading researchers on the topic.  Hyperserotonemia does seem an acceptable term in this case, especially in combination with the link provided.  I will not change anything unless someone agrees with me, but hopefully I have provided sufficient reasoning to support a little rewording around this section.  --164.107.94.247 (talk) 09:30, 13 April 2011 (UTC)
replies: text: I've never heard it called "hypersorotonemia." At least in clinical use, the usual term seems to be "serotonin syndrome."  I agree that the former is misleading, not only for the reason you give, but also because the syndrome is mediated primarily by serotonin in the CNS, not in the bloodstream in general.  Whatever you end up calling it (I checked, BTW, and the Wikipedia article calls it serotonin syndrome), you should emphasize that it is severe and potentially fatal.  Besides hyperpyrexia, patients suffering from serotonin syndrome can present with nausea/vomiting, dilated pupils, nystagmus, diarrhea, rapid breathing, shivering or chills, mental status changes (up to and including mania, psychosis, or coma), excessive sweating, ataxia, labile blood pressure, tremor, myoclonus, muscular rigidity, and seizures.  (The signs and symptoms break down into three broad categories: autonomic, neuromuscular, and psychiatric.) 174.111.242.35 (talk) 15:54, 9 June 2011 (UTC)
thread_title:  Dangers 

message: Rhodiola Rosea is listed both as an MAOI and as a substance which should not be taken with an MAOI.
So Rhodiola Rosea should not be taken with itself? :D
Ppw0 (talk) 05:25, 2 May 2012 (UTC)
thread_title:  Rhodiola? 

message: Hong-Fang Ji and Liang Shen (2011) "Berberine: A Potential Multipotent Natural Product to Combat
Alzheimer’s Disease" Molecules 2011, 16, 6732-6740; doi:10.3390/molecules16086732
Hong-Fang Ji and Liang Shen (2012) "Molecular Basis of Inhibitory Activities of Berberine against Pathogenic Enzymes in Alzheimer's Disease" ScientificWorldJournal. 2012: 823201. Published online 2012 January 4. doi:10.1100/2012/823201
Kong LD, Cheng CH, Tan RX. "Monoamine oxidase inhibitors from rhizoma of Coptis chinensis" Planta Med. 2001 Feb;67(1):74-6. http://www.ncbi.nlm.nih.gov/pubmed/11270727
Oceanlab (talk) 17:04, 21 July 2012 (UTC)
thread_title:  Berberine should be added to the list of reversible MAOIs, with preference for MAO-A and less pronounced interaction with MAO-B.  

message: I think SJW should be added to the list of herbal MAOIs.  — Preceding unsigned comment added by 76.91.29.44 (talk) 07:04, 3 December 2012 (UTC)
thread_title:  St. John's Wort 

message: Here's the info I'm going by:
http://i.imgur.com/UKNfYJK.gif
Tetrahydro-β-carbolines, Potential Neuroactive Alkaloids, in Chocolate and Cocoa. Tomas Herraiz, J. Agric. Food Chem., 2000, 48 (10), pp 4900–4904
Full paper: http://freakshare.com/files/cw8me933/Tetrahydro-Beta-carbolines---potential-neuroactive-alkaloids-in-chocolate-and-cocoa.pdf.html  — Preceding unsigned comment added by 108.41.205.78 (talk) 18:38, 28 January 2013 (UTC)
thread_title:  Add cacao to list of MAOIs? 

message: "Nutmeg" Wikipedia page says:
nutmeg contains myristicin, a monoamine oxidase inhibitor  — Preceding unsigned comment added by EricStruble (talk • contribs) 00:27, 27 February 2013 (UTC)
thread_title:  Add Nutmeg to List? 

message: Lemon Balm(ref)(/ref)
Some anonymous IP editors want to include the text above in the article.  I do not believe that the Journal of Student Research is a reliable source. I have opened a discussion on it here.   IP editors, please do not edit war - let's see what the notice board has to say. Jytdog (talk) 05:03, 28 August 2013 (UTC)
replies: text: I has also opened a 3RR notice here and the article was semi-protected today.  Jytdog (talk) 22:11, 28 August 2013 (UTC)
thread_title:  Content supported by article in the Journal of Student Research 

message: Can anyone with expertise on this topic explain to me why I just got off the phone with my pharmacist, and she told me that Bupropion, dextroamphetamine, and Fluoxitine are NOT MAOIs, yet these (as well as many more) are listed on this page? I was afraid I might have had a triple interaction with the cold medicine I took! This is potentially dangerous information if it is true! Knowledge is NOT power, having precisely the right knowledge at the right moment is. (talk) 19:37, 25 January 2014 (UTC)
replies: text: really important point - if you are looking anywhere for health information, you should read carefully!  This article does NOT say that Bupropion, dextroamphetamine, and Fluoxitine are MAOIs.  It says that those drugs interact with MAOIs.  Very very different. Jytdog (talk) 00:18, 26 January 2014 (UTC)
replies: text: The crazy list on this page has been bothering me too.  I removed the clutter about herbal this or that, and also the research compounds, and left the drugs.  Am going to through them and verify them now.  btw, Wikipedia strives to provide accurate information but you should not rely on it for health-related matters.Jytdog (talk) 20:45, 25 January 2014 (UTC)

text:  Pirlindole has been used for a long time in Russia, see  http://books.google.com.au/books?id=L-dI4sK_40MC&pg=PA337&dq=Pirlindole+Russia&hl=en&sa=X&ei=mGLkUvCoO47GkQWBvoFw&ved=0CCsQ6AEwAA#v=onepage&q=Pirlindole%20Russia&f=false
'is effective short-acting antidepressant employed in medical practice (Mashkovsky,1993)'       Woodywoodpeckerthe3rd (talk) 01:20, 26 January 2014 (UTC)
replies: text: Great, will add Pirlindole (Pirazidol) back.  Thanks! Jytdog (talk) 02:16, 26 January 2014 (UTC)
thread_title: Inaccurate Information concerning what constitutes an MAOI on this page

message: Tryptamines: DMT (Prevents your body from digesting it, allowing one to experience effects by taking it orally i.e. by Ayahuasca), psilocin/psilocybin ("Magic Mushrooms"), etc.
Can someone clarify WHAT prevents WHAT from digesting WHAT? Doesn't necessarily sound like a dangerous interaction. Just that one cancels the other out. But which? 
:It's not at all dangerous, which is one reason why the list's label as "Interactions" is misleading. DMT is broken down by monoamine oxidase enzymes, just as they break down tyramine (which can cause high blood pressure). It's probably not clear enough that this is what Monoamine Oxidase enzymes do- this is their function, and this is what Monoamine Oxidase Inhibitors inhibit! Cuvtixo (talk) 00:17, 7 February 2019 (UTC)
thread_title:  Tryptamines as interaction: what does what? 

message: Linezolide is a MAO-inhibitor, even if it is not used as such, but as antibiotic against MRSA.
However, if given with antidepressants, it can trigger serotonerg toxicity... 
Vibackup (talk) 13:26, 27 June 2018 (UTC)
replies: text: actually this information is also unclear, not clarifying. Does "antidepressants" include SSRIs, SNRIs, tricyclics, and bupropion? Obviously it would increase the amount of inhibition when combined with MAOI antidepressants, but that would not trigger serotogenic toxicity.  This is a major problem with warnings about interactions with "antidepressants" in the literature in general. These studies generally seem to expect that doctors would do further research upon seeing the term "antidepressant". It is misleading though, because there are many different types of antidepressants which work differently, sometimes significantly so. Cuvtixo (talk) 00:27, 7 February 2019 (UTC)
thread_title:  Should linezolide/Zyvoxid be added? 

message: You guys are kidding us right? 
 "There are reports of MAOI efficacy in obsessive-compulsive disorder (OCD), trichotillomania, dysmorphophobia, and avoidant personality disorder, but these reports are from uncontrolled case reports.[22]"
And to top it off, ref 22 is 30 years old?  Kinda grabbing at straws, aint we?  Stuff like this makes the other miracle claims (compared to SRIs) seem questionable.  <BR> --2602:306:CFCE:1EE0:A482:970D:1E7F:277B (talk) 02:59, 24 April 2020 (UTC)
replies: text: nah sport, no one has vested interests in 50 yo antiquated drugs that have already been ruled to obsolescence by the sris you mentioned, lmao. 2603:8080:1940:900:690D:6342:A226:72E5 (talk) 12:25, 21 December 2020 (UTC)
thread_title:  POV? Reads like a paid ad. 

message: Page says it's still in use in France, Iproniazid's Wiki page says it was withdrawn in France in 2015. There's no specific source for it on that page, so I'm loathe to just go ahead and amend it here. CamphorNoodles (talk) 14:17, 10 December 2022 (UTC)
thread_title:  Iproniazid