Talk:Eszopiclone

message: The last few sentences of the introduction seem a little biased/irrelevant. Specifically:
All clinical trials of eszopiclone published so far are industry funded by the pharmaceutical manufacturer of eszopiclone, Sepracor. Eszopiclone (Lunesta) along with other "Z Drugs" including zolpidem (Ambien), zaleplon (Sonata) are the most commonly prescribed sedative hypnotics in the USA. There were 43 million prescriptions issued for insomnia medications during 2005 in the USA which generated a total of $2.7 billion for pharmaceutical companies.
It's not that the information is not important: certainly 43 million prescriptions in 2005 is a noteworthy fact. However, the wording seems to imply that the drug companies are urging doctors doctors to prescribe hypnotics for a financial, rather than medical incentive. This part of the introduction does not seem to follow the general form of an introductory paragraph on Wikipedia. I do not dispute the well-cited facts. Rather I believe that because of the wording and the order the facts are displayed, the paragraph seems to imply: "All the research that doctors have at their disposal when prescribing one of these medicines is funded by the drug companies. Consequentially, 43 million scrips were issued in 2005 alone, perhaps because the drug companies published positive research. As a result, the drug companies earned $2.7 billion dollars."
If I were to reword this I would write:
The manufacturer of eszopiclone, Sepracor, has published all clinical trials of the drug so far (correcting the passive voice). Eszopiclone (Lunesta) is one of the most prescribed medicines for insomnia is the US. Doctors prescribed eszopiclone and the other "Z Drugs", namely zolpidem (Ambien) and zaleplon (Sonata), 43 million times in 2005 alone for a total of $2.7 billion of sales.
I feel that wording is much more neutral. It is clear that the $2.7B went to the drug companies but clearly stating it along with the way the other facts are presented implies that the drug companies are only seeking profit. How about the fact that 43 million people, a sizable chunk of the US population, probably got a great deal of relief from insomnia because of the drug companies? I do not want to change the wording, however, without some imput from the Wikipedia community as I am a long-time reader, short-time contributor. Thanks in advance for your input!--Rotellam1 (talk) 03:10, 4 March 2010 (UTC)
thread_title: Neutrality Issue: Introduction Bias?

message: This word is listed under the section about overdose, and possible symptoms of an overdose of this drug. I for one cannot seem to find the definition of this word through any searches that I've used, and only real mention I'm seeing to the word itself through google etc. is the second source that cites it (#19), which is a med. journal that I can't access without paying.  Do you think we could put a short layman's description of the condition after the word? tonyb983 01:10, 15 October 2009 (UTC)
thread_title: Troponemia

message: I'd like to see some information about side effects, abuse, and effects in general.
:At first I thought I was the only one misspelling Lunesta as "Lunestra," but it seems I'm not. Is it within Wikipedia's rules to set up a redirect page from a misspelling? If so, uh, I don't know how to do it...  McGehee 02:25, 8 January 2007 (UTC)
thread_title: Abuse

message: Is there gonna be any information about the commercials? Angie Y. 17:00, 1 October 2006 (UTC)
replies: text: I cannot provide that information due to copyright violations. :-) Carlo Banez (talk) 17:13, 15 April 2008 (UTC)
thread_title: Commercial spots

message: I tried Lunesta once; when they say unpleasant taste, it truly is horrid, to the extreme. This being only a personal experience of mine, I didn’t like the taste (obviously); I know it may seem silly but I wanted to get my taste ‘corrected’ immediately, so I ate some food, checking to see if it was better, but I scarcely ‘touched’ my food at all as it was the worst 'food' I’ve ever tasted. Instead, I slept it off; Still had a little after taste in the morning but never took Lunesta again.
Joey 08:39, 25 December 2006 (UTC)
replies: text: That's odd. I just swallow the pill and don't taste it at all. McGehee 02:27, 8 January 2007 (UTC)

text: I, too, experienced the horrible, HORRIBLE taste.  The first time I tried it, I didn't notice anything unusual because I swallowed it right away.  But the second time, I put it on my tongue and then spent a few seconds looking for a drink to wash it down.  During that short time, the pill apparently partially dissolved and this unbelievably bad "chemical" taste overwhelmed my mouth, and I couldn't wash it out or do anything to get rid of it.  It was far and away the most powerfully bad taste I had ever experienced in my life.  "Unpleasant?"  Ha!  That doesn't even begin to describe it.  It was awful.  24.6.66.193 (talk) 23:30, 15 December 2007 (UTC)
thread_title: Unpleasant Taste

message: I have been taking Lunesta for 6 months.  I believe it is causing canker sores on my tongue.  I get canker sores, sometimes several, about every week. Since this medication has such an acidic taste, I wonder if it is causing this.  Has anyone else experienced this? —The preceding unsigned comment was added by 74.140.236.234 (talk) 01:04, 24 January 2007 (UTC)
thread_title:  Canker sores 

message: Take a look at the Wiki on Lunesta's sister drug, Imovane (Zopiclone). Imovane has a pronounced side effect in some people - bitter or metallic taste which can carry into the next day.  
Personally, I tried both Zopliclone and Lunesta (separately) and experienced a moderate metallic taste with both drugs. In particular, I noticed a strong bitter taste when I cut a Lunesta tablet in half for a half dose. I think that is the reason why the 3 mg Lunesta dose is coated in a neutral shell - to keep the taste off the tongue. When I did not cut a pill in half there was still a moderate metallic morning mouth that slowly vanished.
BTW: If your prescriptions are not covered and you cannot afford Lunesta's high price, go to GetCanadianDrugs.com or elsewhere in Canada and try Zopliclone. Its not available in the USA. Lunesta's firm banned Zopliclone from the USA after it won a US patent for Lunesta. Zopliclone is available worldwide and is well understood.  Its a fraction of the cost of Lunesta and is very likely just a effective. 
Of course, TALK to your doctor, FIRST.
OBOE —The preceding unsigned comment was added by Oboist1 (talk • contribs) 23:15, 19 February 2007 (UTC)
replies: text: yes this can be extremely unpleasant. It bothers me because its more than just a "taste", as even when you breathe in and out you can get a hint of that metallic just BLAH taste thats in your mouth. Anything I have for breakfast is completely tainted. The BEST way to combat this side effect that I have found is to gargle some PINEAPPLE and/or ORANGE juice. I do both in the morning and it helps a little, but the aftertaste is so strong that it even would be noticeable when I am eating lunch the next day! Although luckily it has never lasted for more than about the mid day of the next day you are taking it.  —Preceding unsigned comment added by 24.136.126.165 (talk) 15:14, 9 November 2007 (UTC)
thread_title:  Bad Mouth Taste 

message: How can "death by overdose (rare)" be a withdrawal symptom?  If you are withdrawing, it doesn't seem possible to overdose.  Should that be taken out? --BennyD 00:08, 9 November 2007 (UTC)
thread_title:  Withdrawal Symptoms 

message: If you let the pill sit in your mouth without washing it down immediately, it is really
bitter.  
:Yeah, I discovered that the hard way.  (See my comments above, under "Unpleasant taste") 24.6.66.193 (talk) 23:40, 15 December 2007 (UTC)
replies: text: I tried fruit juice and the Lunesta taste just kicked its ass. 24.6.66.193 (talk) 23:40, 15 December 2007 (UTC)
thread_title:  Taste 

message: Please refer to: http://en.wikipedia.org/wiki/Talk:Zolpidem#Carcinogenicity  The same section has been included in this article. Paul Fisher (talk) 10:07, 16 May 2008 (UTC)
thread_title:  Carcinogenicity 

message: For the USA users of Eszopiclone
I just would like you to notice that the equivalent drug known as "Zopiclone" is available in Israel for just about 3.8 $ (US Dollars) per 20 tablets, it comes to (about) 19 cents per 1 Zopiclone tablet of 7.5 mg  = (about) 3.75 mg of Eszopiclone. This is less then 1/10 of its price in the US.
The only difference between Zopiclone and Eszopiclone is that Zopiclone contains Eszopiclone + the other (pharmacologically non-active) isomer of that drug.
Please read the chapter "Availability in Europe" in this Wikipedia article to see that the EMA (the European Union's equivalent to the US FDA) stated it would not be granting Eszopiclone 'new active substance' status, as it was essentially pharmacologically and therapeutically too similar to Zopiclone.
written for you by a Zopiclone user in Israel.  — Preceding unsigned comment added by 109.186.126.105 (talk) 14:09, 30 October 2011 (UTC)
thread_title:  Cost in the USA 

message: Systematic review says "Although the drug effect and the placebo response were rather small and of questionable clinical importance"
User:Dfdemt appears to be calling the BMJ here a "sketchy source"?
Doc James (talk · contribs · email) 00:35, 24 December 2017 (UTC)
thread_title: BMJ from 2012

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thread_title:  External links modified