Talk:Har Gobind Khorana

message: He is Indian and we are proud to be Indian. Please stop changing history. (He was born in India he has a birth certificate from India not Pakistan)      — Preceding 
unsigned comment added by 72.81.192.182 (talk) 01:50, 30 January 2012 (UTC)
thread_title: Untitled

message: i just wanted to say hi so hi guys!!!!!!! peace out 2018-9-jan!!!!!!!!!!!   — Preceding unsigned comment added by 205.123.51.82 (talk) 17:37, 9 January 2018 (UTC)
thread_title: Untitled

message: This article says he was born in Raipur, Pakistan. But the link goes to a Raipur in India. Two other Wikipedia articles say India. The Nobel Prize site says Pakistan. Brutannica 04:37, 29 April 2006 (UTC)
replies: text: I've corrected it link to Raipur, Pakistan. Which are the other two wikipedia articles? Jay (talk) 09:36, 24 December 2008 (UTC)
thread_title: Raipur

message: The person 72.64.122.196 is continuing to vandalize the page by insisting on changing the name of Dr Khorana (adding a "Singh") and so on. 
DaveBorman 22:54, 29 January 2007 (UTC)
thread_title: Continuing Vandalism by 72.64.122.196

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thread_title: File:HarGobindKhorana 19070.jpg Nominated for Deletion

message: Shocking to read such faulty descriptions of the cause of death here, and in the news; especially in the case of this biochemist!  Please, he died of cancer or something else specific.  Don't  insult the man by resorting to unscientific garbage statements like "natural causes".  — Preceding unsigned comment added by 75.85.14.106 (talk) 11:05, 15 November 2011 (UTC)
replies: text: "Natural causes" is a commonly-accepted definition for death due to illness, and is typically used by those responsible for recording cause of death - see https://en.wikipedia.org/wiki/Death_by_natural_causes 216.68.184.194 (talk) 12:26, 9 January 2018 (UTC)
thread_title:  Khorana would have known there is no "natural causes" of death 

message: Im pretty sure that Sir Alexander Todd was the first to chemically synthesize a thymidine dimer using the "phosphotriester method" in 1955 ref (Michelson, A.M. & Todd, A.R. Nucleotides. XXXII. Synthesis of a dithymidine dinucleotide containing a 3',5'-internucleotidic linkage. Journal of the Chemical Society, 2632-8 (1955).)  
Khorana did work with Todd in 1953, and published a paper, but it was not on the synthesis of nucleotides, but rather on pyrophoaphate synthesis.
He then later, in his own group, published a paper in 1958 regarding the synthesis and study of a thymidine dimer
Ref(Gilham, P.T. & Khorana, H.G. Studies on Polynucleotides. I. A New and General Method for the Chemical Synthesis of the C5′-C3′ Internucleotidic Linkage. Syntheses of Deoxyribo-dinucleotides1. Journal of the American Chemical Society 80, 6212-6222 (1958).)
:::Here is what the Nobel Committee says: https://www.nobelprize.org/educational/medicine/gene-code/history.html
   Solving the Rest of the Puzzle Har Gobind Khorana, at the University of Wisconsin, devised precise and intricate biochemical methods to produce well-defined nucleic acids, long strands of RNA with every nucleotide in exact position. The first one he made was a strand repeating the two nucleotides UCUCUC. This translated into a strand of amino acids, reading serine-leucine-serine-leucine... Synthetic RNA were later used to decipher the rest of the genetic code.
Peter K Burian (talk) 19:03, 9 January 2018 (UTC)
thread_title:  Not the first to synthesize oligonucleotides 

message: The article says he was born in 1922,  but then suddenly he disappears for 30 years until he reappears when joining the faculty of University of British Columbia in 1952. That's a huge gap that needs filling. Where did he go to school and university etc? Moriori (talk) 19:56, 8 January 2018 (UTC)
replies: text: If you read the article now, you should not find huge gaps. I added a lot of content, now fully cited. Peter K Burian (talk) 18:42, 9 January 2018 (UTC)
thread_title:  What happened to this man in the missing 30 years? 

message: His son's name was Dave, not Davel. From the link listed already: http://news.mit.edu/2011/obit-khorana-1110 2600:6C50:417F:D887:2D04:6510:9ACA:4F05 (talk) 06:27, 9 January 2018 (UTC)
replies: text: Already done. Ivanvector (Talk/Edits) 13:51, 9 January 2018 (UTC)
replies: text: I agree; the article now shows his name as Dave. Peter K Burian (talk) 18:21, 9 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: His name in Punjabi is ਹਰ ਗੋਬਿੰਦ ਖੁਰਾਨਾ 70.16.208.64 (talk) 10:48, 9 January 2018 (UTC)
replies: text: Not done: please provide reliable sources that support the change you want to be made. Ivanvector (Talk/Edits) 13:52, 9 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: 103.206.105.134 (talk) 11:10, 9 January 2018 (UTC)
replies: text: Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format. Ivanvector (Talk/Edits) 13:42, 9 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: http://www.nytimes.com/2011/11/14/us/h-gobind-khorana-1968-nobel-winner-for-rna-research-dies.html
http://www.telegraph.co.uk/news/obituaries/science-obituaries/8892230/H-Gobind-Khorana.html
https://www.washingtonpost.com/local/obituaries/h-gobind-khorana-biochemist-and-nobel-prize-winner-dies/2011/11/11/gIQAe4rIDN_story.html?utm_term=.8df04282077e
https://www.the-scientist.com/?articles.view/articleNo/31398/title/Har-Gobind-Khorana-Dies-at-89/  — Preceding unsigned comment added by 2601:186:202:348:7987:6B4E:3DE4:3194 (talk) 12:40, 9 January 2018 (UTC)
replies: text: I updated Personal Life about his death and family. What more information is needed?? Peter K Burian (talk) 18:43, 9 January 2018 (UTC)
thread_title:  Needs Update to Clearly Reflect Subject's Death in 2011 

message: Where the article talks about his marriage, a chunk of the text is almost a direct quote from Dr. Khorana's writing and should be attributed. From Wikipedia article: "Har Gobind Khorana was married in 1952 to Esther Elizabeth Sibler, who is of Swiss origin. Esther brought a consistent sense of purpose into his life at a time when, after six years' absence from the country of his birth, Khorana felt out of place everywhere and at home nowhere."
The quote is quoted in the followng NYT article, though they don't have a specific reference for it: http://www.nytimes.com/2011/11/14/us/h-gobind-khorana-1968-nobel-winner-for-rna-research-dies.html 170.140.182.106 (talk) 14:18, 9 January 2018 (UTC)
replies: text: Corrected. See my Talk topic about content copied from other sources. I have deleted all of that and replaced it with facts, fully-cited from reliable sources. Peter K Burian (talk) 18:22, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: Ribonucleic acid (RNA) with three repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This, combined with the Nirenberg and Leder experiment, showed that UCU codes for serine and CUC codes for leucine.
--->
Ribonucleic acid (RNA) with two repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This, combined with the Nirenberg and Leder experiment, showed that UCU codes for serine and CUC codes for leucine.
Auckerman (talk) 15:10, 9 January 2018 (UTC)
replies: text: From a scientific article. 
Dr Khorana had shown that a ribonucleic acid (RNA) with three repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids.
http://www.animalresearch.info/en/medical-advances/nobel-prizes/the-role-of-the-genetic-code-protein-synthesis/ Content such as that should be quoted when requesting a revision, IMHO. But all of this is beyond my scope too due to its complexity. Peter K Burian (talk) 19:14, 9 January 2018 (UTC)
replies: text: Thanks for your reply! In the context of the source article, 
Independently, Dr Khorana had shown that a ribonucleic acid (RNA) with three repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This, combined with the Nirenberg and Leder experiment, showed that UCU codes for Serine and CUC codes for Leucine. He also showed that RNAs with three repeating units (UAC UAC UAC, or ACU ACU ACU, or CUA CUA CUA) produced three different strings of amino acids. RNAs with four repeating units including UAG, UAA, or UGA, produced only dipeptides and tripeptides thus revealing that UAG, UAA and UGA are stop codons.
The first "three" is clearly a typo and should read "two". UC is two units, UAC is three. I am admittedly new to wikipedia, but it seems that if there's a typo in the source material it should be okay for the article not to reflect that.
Here http://www.bio-medicine.org/biology-definition/Har_Gobind_Khorana/ is a source with "two" in the correct place:
RNAs with two repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This combined with the Nirenberg and Leder experiment showed that UCU codes for Ser and CUC for Leu.
Auckerman (talk) 15:16, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 - Typo in Research Work 

message: Under "Born" information, Raipur should be categorized as Pakistan. This town of Raipur, is part of pre-partition Indian subcontinent (when Pakistan and India were one) but after partition once India and Pakistan were separate countries it has never been an Indian town but Pakistani, India did not exist as a independent country before partition in 1947 . The Indian Raipur is a city in Raipur district, the erstwhile capital city of the Indian state of Chhattisgarh
"Born	January 9, 1922
Raipur, Punjab, India" Shockchaudry (talk) 15:42, 9 January 2018 (UTC)
replies: text: I agree. From the current version of the article, fully cited: During a brief period in 1949, he was unable to find a job in his home province of the Punjab, which was by then part of Pakistan. Peter K Burian (talk) 18:42, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: In Residence section, Mr Khorana is listed having lived in India, United Kingdom and United States. However, Mr Khorana also lived in Switzerland and Canada. These two countries should be added. Kevlangdo (talk) 16:12, 9 January 2018 (UTC)
replies: text: The personal life section DOES cover Canada and Switzerland; unfortunately, nearly that entire section is copied from a book, Physiology Or Medicine, 1963-1970
edited by Jan Lindsten
   https://books.google.ca/books?id=O5jQ-GRTvPUC&pg=PA370&lpg=PA370&dq=mahan+singh+professor+researcher+Punjab+university&source=bl&ots=vXbrdAsnTG&sig=hrmK6ZPr8wMcH4Q5rHdqtCBFrqw&hl=en&sa=X&ved=0ahUKEwjcnPChp8vYAhVY1GMKHZTcABUQ6AEIOzAD#v=onepage&q=mahan%20singh%20professor%20researcher%20Punjab%20university&f=false 
Peter K Burian (talk) 16:40, 9 January 2018 (UTC)
replies: text: I deleted content that had been copied from a book. The current content includes facts, all fully cited. Peter K Burian (talk) 18:39, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: Much of the Personal Life is copied from this book: Physiology Or Medicine, 1963-1970
edited by Jan Lindsten
See https://books.google.ca/books?id=O5jQ-GRTvPUC&pg=PA370&lpg=PA370&dq=mahan+singh+professor+researcher+Punjab+university&source=bl&ots=vXbrdAsnTG&sig=hrmK6ZPr8wMcH4Q5rHdqtCBFrqw&hl=en&sa=X&ved=0ahUKEwjcnPChp8vYAhVY1GMKHZTcABUQ6AEIOzAD#v=onepage&q=mahan%20singh%20professor%20researcher%20Punjab%20university&f=false
I am trying to paraphrase content to minimize the problem but SO much of that section is directly from the book, that I don't know how to proceed.
Peter K Burian (talk) 16:45, 9 January 2018 (UTC)
replies: text: Here is a useful article that could be used when paraphrasing the content about his life. (NOT copying the article) https://www.vox.com/2018/1/9/16862980/google-doodle-har-gobind-khorana-genetics-dna Peter K Burian (talk) 16:58, 9 January 2018 (UTC)
replies: text: Problem solved, for the most part. I deleted most of the content that had been copied from the book and added facts that are now fully cited from sources such as MIT and obituaries in major news media. Peter K Burian (talk) 17:41, 9 January 2018 (UTC)
thread_title:  Too much of the article is copied from a book 

message: Birth place was in "British India" and not Pakistan( no such country existed back then ) 156.75.247.2 (talk) 16:46, 9 January 2018 (UTC)
replies: text: Agreed; 
   From the Personal Life section (fully cited): During a brief period in 1949, he was unable to find a job in his home province of the Punjab, which was by then part of Pakistan.
Peter K Burian (talk) 18:41, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: in the end of "awards and honors" there is a mention of the google image "ee-letter The illustration depicted his use of thrcombinations to represent the four chemical bases found in RNA" this is not accurate. The image depicts his discovery that three letters of RNA code for each amino acid. source: https://www.nature.com/scitable/definition/genetic-code-13 Es2241 (talk) 16:48, 9 January 2018 (UTC)
replies: text: OK, then revise a few words of the article to specify the correct information.
The article should state instead:  "The image depicts three letter RNA codons to represent his work deciphering the code of RNA and determining which three-letter codon matches which amino acid". source: https://www.nature.com/scitable/definition/genetic-code-13   (I can not make this change myself because the page is locked.  someone else has to update this for me)  Es2241 (talk) 18:06, 9 January 2018 (UTC)
replies: text: There are two previous requests for revision (Talk topics) that discuss the accuracy of the RNA statement. Have you read those? Peter K Burian (talk) 19:16, 9 January 2018 (UTC)
thread_title:  google image 

message: How is it possible that he apparently studied for and received a Phd. from U. Liverpool during 1945-48 while (at the same time?) studying for and receiving an MS from U. Punjab? Please clarify the timing. 100.2.184.28 (talk) 16:51, 9 January 2018 (UTC)
replies: text: The article was wrong; he got his only Phd. in the UK. The article is correct now.
    Khorana attended high school in the nearby city of Multan before enrolling in Punjab University, where he received his bachelor’s degree in 1943 and master’s in 1945, both in chemistry and biochemistry. Upon graduating, he received a fellowship from the Indian government to study at the University of Liverpool in the U.K., where he received his PhD in 1948. http://news.mit.edu/2011/obit-khorana-1110
Peter K Burian (talk) 17:24, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: I am adding this to the talk page to save and share what looks like a good source for some of the missing details of Har Gobind Khorana and/or his family. It will take me some time to process and assess the information for inclusion in the Wikipedia article.
The three part article published in India Abroad a newspaper based in New York City. https://en.wikipedia.org/wiki/India_Abroad
Part I:   Dr Khorana, 'Nobel laureate and one of science's immortals'
Part II:  Dr Khorana: 'Considerate, most remarkable man'
Part III: Dr Khorana: 'A loving father, a caring mentor'
This URL jumps to part III because they added links in part III that jump to parts I and II.
http://www.rediff.com/news/slide-show/slide-show-1-dr-khorana-a-loving-father-a-caring-mentor/20111128.htm  — Preceding unsigned comment added by Rodb56 (talk • contribs) 17:40, 9 January 2018 (UTC)
thread_title:  Possible reference for some missing details 

message: Place of residency should include Pakistan since he was born there. Miyunus (talk) 17:42, 9 January 2018 (UTC)
replies: text: No, he was not born in Pakistan. See these sentences from the Personal Life section, all with citations:
   Khorana lived in India until 1945, ... During a brief period in 1949, he was unable to find a job in his home province of the Punjab, which was by then part of Pakistan.
Peter K Burian (talk) 18:38, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: Khorna should be changed to Khorana 24.80.226.255 (talk) 18:06, 9 January 2018 (UTC)
replies: text: Yes. "Har Gobind Khorana" is the correct spelling. Is there a mistake somewhere in the article? https://www.vox.com/2018/1/9/16862980/google-doodle-har-gobind-khorana-genetics-dna
Peter K Burian (talk) 18:19, 9 January 2018 (UTC)
replies: text:  Not done: The page's protection level has changed since this request was placed. You should now be able to edit the page yourself. If you still seem to be unable to, please reopen the request with further details. —MRD2014 Talk 00:41, 10 January 2018 (UTC)
thread_title:  Semi-protected edit request on 9 January 2018 

message: Someone keeps changing this but the heading above is correct. See the Raipur, Pakistan article, for example. 
AND this book, which confirms that by 1949, the town was in Pakistan. Asian Americans: An Encyclopedia of Social, Cultural, Economic https://books.google.ca/books?id=3AxIAgAAQBAJ&pg=PA653&dq=early+life+har+gobind+khorana&hl=en&sa=X&ved=0ahUKEwiNreuXt8vYAhVOxGMKHW7dB10Q6AEILDAB#v=onepage&q=early%20life%20har%20gobind%20khorana&f=false 
AND this book Encyclopaedia of India, Pakistan and Bangladesh
https://books.google.ca/books?id=eENU_a8c79MC&pg=PA890&dq=Raipur+originally+in+India+and+now+Pakistan&hl=en&sa=X&ved=0ahUKEwiew7Tp9MvYAhVB6GMKHad_CHUQ6AEIKTAA#v=onepage&q=Raipur%20originally%20in%20India%20and%20now%20Pakistan&f=false 
AND this book Encyclopedia of World Scientists  https://books.google.ca/books?id=uPRB-OED1bcC&pg=PA396&dq=Raipur+originally+in+India+and+now+Pakistan&hl=en&sa=X&ved=0ahUKEwiew7Tp9MvYAhVB6GMKHad_CHUQ6AEINjAC#v=onepage&q=Raipur%20originally%20in%20India%20and%20now%20Pakistan&f=false
 
Peter K Burian (talk) 22:18, 9 January 2018 (UTC)
thread_title:  Raipur WAS in India but now, it is [[Raipur, Pakistan]] 

message: I don't know how this problem suddenly occurred in the infobox
Born	January Expression error: Missing operand for *., 1922Expression error: Unexpected > operator
Raipur, British India, Punjab, British India
I hope someone can fix it. He was born in Raipur which was then in British India, but by 1949 was part of Pakistan. See Raipur, Pakistan.
I assume that there is some debate about the India/Pakistan aspect but as the previous Talk item indicates, major sources confirm it was in India and then became part of Pakistan.
In any event, at the time of his birth it was part of India.
Peter K Burian (talk) 22:33, 9 January 2018 (UTC)
replies: text: It was subsequently fixed by 71.202.235.29. Thanks, Peter K Burian (talk) 22:35, 9 January 2018 (UTC)
thread_title:  HELP, fix coding re Birth Place 

message: We have seen a few issues of vandalism this afternoon, such as this one indicating Iran. In spite of being semi-protected.
https://en.wikipedia.org/w/index.php?title=Har_Gobind_Khorana&diff=next&oldid=819532939
And this one. https://en.wikipedia.org/w/index.php?title=Har_Gobind_Khorana&diff=next&oldid=819531319
So this article definitely needs some protection. @User:Ivanvector, was the protection removed? How can those users be making changes? 
Peter K Burian (talk) 22:58, 9 January 2018 (UTC)
thread_title:  There is still vandalism to this article! Needs protection 

message: isnt their a JBC paper with Malcolm Gefter that describes PCR in the discussion ?
I always assumed it wasn't noticed cause a) oligos were $$ and b) there wasn't a lot of DNA seq info available, so it wasn't that useful — Preceding unsigned comment added by 50.245.17.105 (talk) 12:51, 14 July 2021 (UTC)
thread_title: subsequent research and anticipation of PCR