Talk:Desiccated thyroid extract

message: While I think this article is well done, I wonder about the use of a question format in the last section of the article.  Is there a way to write this section so that instead of questions, these uncertainties could be presented in a more encyclopedic format?  I may attempt to edit this in the future, if there are not good reasons to leave this question format. --Coppercable (talk) 20:13, 7 July 2010 (UTC)
thread_title:  Encyclopedic Tone? 

message: I've archived the old talk page. This article is missing one of the few trials on DTE, which I found on the hypothyroidism article. I have verified that dessicated thyroid extract was used in this trial: * — Abstract
This was not a controlled trial. It simply found that some patients who didn't respond to T4 responded to T4 + T3. Impossible to know whether synthetic T4 + T3 would have had the same result. II | (t - c) 03:41, 7 March 2009 (UTC)
thread_title:  Clinical trial 

message: Whilst the Armour company is the best known now, the medical literature is replete with references to glandular preparations (including, but not just, desiccated thyroid) supplied by "The Wilson Laboratories" of Chicago Il (Part of Wilson and Company - another huge meat packer). I understand Wilson Laboratories were subsequently bought by Inolex. Various staff also published papers whilst working for "The Wilson Laboratories", mostly on the correct preparation of glandular products.
Seems to be a whole history of glandular preparations and research largely not yet listed in Wikipedia.  —Preceding unsigned comment added by 84.45.158.52 (talk) 14:31, 18 March 2009 (UTC)
thread_title:  Wilson's Dessicated Thyroid? 

message: No mention is made that in a number of trials of combined T4 and T3 versus T4, patients express a preference for the combined treatment, even when blinded.
Related to the controversy in desiccated thyroid, as it may be patient preference for combined T4 and T3, has the same basis as the preference for desiccated thyroid. Although none of the studies tie it to any clear change in reported symptoms or measures of psychological well being or mental acuity. It is presumably possible combined therapy improves something that isn't being tested for in the trials.
Some case and anecdotal strong preference for desiccate thyroid are almost certainly due to patients with problems in converting T4 into T3, who receive little benefit (or occasionally adverse effects) from thyroxine only treatment.
Grozinsky-Glasberg et al, 2006 - Provides a review of a number of relevant clinical trials.  —Preceding unsigned comment added by 84.45.158.52 (talk) 20:23, 19 March 2009 (UTC)
replies: text: Grozinsky-Glasberg et al 2006 found only one trial where combination was better than T4 alone ... I'm not seeing the preference either. II | (t - c) 21:48, 19 March 2009 (UTC)
replies: text: Joffe 2007 Not all studies included patient preference, and Grozinsky-Glasberg doesn't list it in the comparison. Found a better review (from this perspective) in Joffe which notes: " in the four studies where patient preference for treatment was assessed, three10,15,16 report patient preference for combination treatment, and only one reports no preference for treatment type.12".  —Preceding unsigned comment added by 84.45.158.52 (talk) 20:09, 11 April 2009 (UTC)
thread_title:  RCT patient preference 

message: Re: Current Status of Thyroid Extract Use
 “When their blood levels of thyroid hormones and TSH are most normal, the majority have no more signs or symptoms of hypothyroidism than similar members of the population.” 
The key word in this sentence is “majority “ – Although the majority of hypothyroid individuals do fine on just synthetic T4 alone – there is a significant minority of individuals that perform best when taking a combination of T4 and T3, within this group there are also individuals that do best when they take desiccated thyroid or a combination of synthetic T4/dessicated thyroid (1, 2).
More recent studies have identified biological factors that may account for these differences.  For example, up to 16% of the population have a genetic variation that decreases the effectiveness of deiodinase D2 enzyme in the conversion of T4 to T3 in target organs.  Individuals that perform better using a T4/T3 combination are more likely to have this genetic variation (3).
1. The New England Journal of Medicine. “Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism”,  Vol. 340, No. 6, 1999.
2. European Journal of Endocrinology. “Effect of combination therapy with thyroxine (T4) and 3,5,30-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study”, 161 895–902, 2009. 
3. Journal of Clinical Endocrinology and Metabolism. “For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale.” May, 2009.  — Preceding unsigned comment added by Bjnorth (talk • contribs) 03:41, 20 October 2011 (UTC)
replies: text: In my opinion, there should be some wiki page or section that deals with the controversy/debate on T3, slow-release T3, T3+T4, and T4 (and maybe desiccated thyroid). Glennchan (talk) 16:49, 5 October 2013 (UTC)
thread_title:  Current status of thyroid extract use 

message: The title of this article is "Desiccated Thyroid Extract", but it sounds more like "Desiccated Thyroid Powder".  An extract is made by using a solvent (typically alcohol) to dissolve soluble compounds for further filtration/purification/concentration.  This is completely different than what this article states.
See: http://en.wikipedia.org/wiki/Extract
As such, an extract contains concentrations of the desired compounds that are hundreds of times higher than the raw material.  Think vanilla extract, which removes and concentrates the essential flavors and leaves everything else behind.  This article is very inaccurate with respect to the discussions about the ingredients of desiccated thyroid extract and how it is made.   Cresard (talk) 09:05, 21 December 2011 (UTC)
thread_title:  Desiccated Thyroid Powder is not the same as Desiccated Thyroid Extract. 

message: I would like to make improvements to this page.  From using the product and surface level research, I would like to work on the following: 1) restructuring the page 2)adding additional information, 3)adding/finding citations to support new and existing information and 4) rewriting content for readability and clarification.  Since I am new to making these types of edits, I would appreciate any assistance with any of the above. Would anyone be willing to collaborate with the research? Thank you!
Presto808 (talk) 16:34, 19 June 2014 (UTC)
thread_title:  Improve readability and information on Desiccated thyroid extract wikipedia page 

message: I changed the introduction for readability. I added comments and references to the medical uses section, and edited for readability. I added comments and a reference to the society and culture section, and edited for readability. I gather there is some disagreement about the article, I hope my additions add balance to the article without negating either POV. My source is the Oxford Textbook of Endocrinology and Diabetes. I did not find a T4 vs T3 controversy section to add to anywhere, but I don't think it's the only issue. I would like to have a look at the history section soon.
Preceole (talk) 14:25, 7 July 2014 (UTC)
thread_title:  Edits July 2014 for balance 

message: This item:
#Desiccated thyroid preparations have a greater variability from batch to batch than synthetic ones.  
Refers to a page that does not support the assertion made.  Since the link was too vague I searched the site for a reference supporting this assertion, non was present either supporting the assertion, or with the stated date.
There was however an article supporting the use of thyroid extract.
http://www.healio.com/endocrinology/thyroid/news/online/%7B0cb20cd0-616e-4a68-a799-760a97f92282%7D/desiccated-thyroid-extract-a-safe-alternative-to-levothyroxine-in-hypothyroidism
As such the material was unsound.  — Preceding unsigned comment added by 82.132.227.101 (talk) 02:35, 3 February 2015 (UTC)
thread_title:  material supported by dead reference removed. 

message: The article is heavily focused on t4, t3, and especially the t4 drug, focus needs to be broadened to include all hormones produced exclusively by the thyroid and contained in this product, which the synthetic drugs lack. 2001:4643:E6E3:0:3417:78E3:5FF8:45A5 (talk) 01:14, 19 September 2021 (UTC)
thread_title:  Need for information on t2 t1 and calcitonin 

message: Levothyroxine means I remain ill for the rest of my life, Armour (or similar "natural" thyroid extracts) mean I get well and can start to enjoy my life again.
All the talk and arguments mean absolutely SFA to me. I will continue to take NDT for the rest of my days. 146.66.61.205 (talk) 20:59, 17 March 2023 (UTC)
thread_title:  Who cares?