Talk:Pancreatic islets

message: While hypothalamic signaling and vascular regulation are both very important to Islet function, the relationship between these processes is tangential at best, and not particularly appropriate for an encyclopedia-level description of islet physiology. I respectfully request that the John Leonora reference/link not be added to the page again, unless a more cogent argument for his inclusion can be provided.  Thanks.
BillyBoy 05:26, 26 April 2008 (UTC)
thread_title:  John Leonora 

message: What do people think of removing these sections?  Most of the information in the transplatation section is already covered in the cell-based therapy section, except for the information about the Pander gene...this seems to be a little far flung into scientific minutiae for the scope of this article.  Also I don't see why the patch clamp information is necessary.  It could be replaced with a couple of sentences about Ca2+ and K+ signaling in the islets, and how gap junctions are required for islet synchrony.  I'd be willing to make the appropriate changes if others feel they are warranted. 
BillyBoy 05:42, 26 April 2008 (UTC)
thread_title:  Necessity of Electical Coupling and Transplantation Sections 

message: I see the article mentions type 1 diabetes, but not type 2? (I don't know if type 1 is even correct)
reference: Butler, A.E. et al. beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes, Diabetes 52, 102-110 (2003)
Redd492 22:00, 14 April 2007 (UTC)
thread_title:  mass of islet of langerhans reduced in type 2 diabetes 

message: "...and beta-cells are coupled electrically to beta-cells (but not to other cell-types)."
Does this mean that beta-cells are coupled to one another, or is it a mistake meaning beta and alpha cells are coupled (this could make sense given their functions)? It's not completely obvious for me. LaFoiblesse 14:36, 26 May 2007 (GMT)
I don't know entirely about the electrical coupling.  I do know that a lot of research has shown that beta-cells are tightly integrated through gap junctions, so that insulin secretion is a concerted response within a given islet to increased glucose concentrations in the blood.
BillyBoy 00:56, 17 June 2007 (UTC)
thread_title:  electrical coupling 

message: While it is still early work, editors here may wish to read "Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes"  in todays Nature.  Be sure to check out the supplementary information. LeadSongDog come howl! 19:06, 18 June 2010 (UTC)
thread_title:  New publication 

message: This article does a great job laying out its contents and discussing the features and functions of pancreatic islets in a concise manner. In addition, throughout most of the article, information is properly cited with functional links. However, the “Clinical Significance” section could use some further revising. The diabetes subsection and the last two paragraphs of the transplantation subsection have no citations, despite containing plenty of information from several outside sources. Furthermore, these subsections feel unbalanced in terms of providing necessary information for the article. The diabetes subsection is underrepresented in this article, and it should be expanded with information from recently published medical reviews and publications. Currently, there is an extensive pool of knowledge about the relationship between nonfunctional pancreatic islets and diabetes (especially type 1 diabetes), but this Wikipedia article hardly covers it. In contrast, the transplantation subsection seems rather long, and some of its content does not seem necessary for this article. For this reason, the transplantation subsection could be written more concisely.
Immcarle38 (talk) 02:11, 29 January 2017 (UTC)
replies: text: Agreed. Have made transplantation section marginally more concise. Will improve further tomorrow. PriceDL (talk) 02:23, 12 February 2017 (UTC)
thread_title:  Citations and Clinical Significance Section 

message: Hormones produced in the pancreatic islets are secreted directly into the bloodstream by five different types of cells. The alpha cells produce glucagon, and make up 15–20% of total islet cells. The beta cells produce insulin and amylin, and make up 65–80% of the total islet cells.  — Preceding unsigned comment added by 2A02:2149:825F:3F00:94A8:F473:2075:91C8 (talk) 15:35, 23 September 2018 (UTC)
thread_title:  Change the phrasing and add it