Talk:Etonitazene

message: This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 07:52, 10 November 2007 (UTC)
thread_title:  WikiProject class rating

message: This article says a related chemical which is yet to have its own article is called 'Nitazene' however the opioid template says that it is called 'Nitazine'. This may cause confusion when the chemical article is created. Nagelfar (talk) 17:24, 9 November 2008 (UTC)
thread_title:  Nitazene / Nitazine 

message: An image used in this article, , has been nominated for deletion at Wikimedia Commons in the following category: Deletion requests January 2012 
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thread_title: File:Etonitazene 2011 synthesis.svg Nominated for Deletion

message: US Patent 2,944,062 describes a derivative with an added amide moiety: CCOC1=CC=C(C=C1)C(C(N)=O)C2=NC3=C(C=CC(N(=O)=O)=C3)N2CCN(CC)CC
My German is very poor but as I understand it, etonitazine which they previously tested was 60x M (by the same team) while examples XIX (above) is x200. The original huge figures are typical of initial patents and such.
212. Benzimidazol-Derivate und verwandte Heterocyclen VI l)
Synthese von Phenyl-[l-aminoalkyl-benzimidazolyl-(2)]-essigsaureestern
und -amiden
von A. Hunger, J. Kebrle, A. Rossi und K. Hoffmann
(19. VIII. 60)
I am afraid I don't know how to change the images but I believe that this racemic derivative is over 3x the parent compound. The amide may be a bioisostere of the beta hydroxy seen in potent fentanyl derivatived, It overlays
the ORL1 full-agonist MCOPPB so maybe, much like combined mu & delta agonism seems to vastly increase analgesic potency (see 14-methoxy metopon), dual mu & ORL1 ligands may be more potent.  — Preceding unsigned comment added by 213.106.56.145 (talk) 11:24, 6 October 2013 (UTC)
thread_title:  Strongest? 

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thread_title:  External links modified 

message: I believe Thomas K Highsmith commited suicide and a batch made in Moscow killed a number of people. I cannot remember where I read it, but I think it's important to make people understand just how dangerous the stuff is.  — Preceding unsigned comment added by 81.99.74.135 (talk) 12:42, 19 January 2017 (UTC)
thread_title:  Deaths 

message: "It is, however, useful in animal models for addiction studies" - what does "animal models" mean? Are these some kind of artificial devices or a euphemism for vivisection? Perhaps we should call things by their real names - animals or animals in labs? Trendorder (talk) 15:08, 13 April 2024 (UTC)
thread_title:  Animal models