Talk:Anticonvulsant

message: I think its worth mentioning that MANY anti-seizure DRUGS have never been APPROVED FOR CHILD USE by the (FDA) Food and Drug Administration in the United States.muncher 15:51, 23 October 2006 (UTC)
thread_title: Suggest We mention Lack of Medication Approval

message: Jean P. Davis M.D., and H.H. Ramsey, M.D.
The demonstration of anticonvulsant activity of the tetrahydrocannabinol (THC) cogeners by laboratory tests (Loewe and Goodman, Federation Proc. 6:352, 1947) prompted clinical trial in five institutionalized epileptic children. All of them had symptomatic grand mal epilepsy with retardation; three has cerebral palsy in addition. EEG tracings were grossly abnormal in the entire group; three has focal seizure activity. Their attacks had been inadequately controlled on 0.13 gm. of Phenobarbital daily, combined with 0.3 gm. of Dilantin per day in two of the patients, and in a third, with 0.2 gm. of Mesantoin daily.
Two isomeric 3(1,2-dimethyl heptyl) homologs of THC were tested, numbers 122 and 125A, with ataxia potencies 50 and 8 times, respectively, that of natural Marijuana principles. Number 122 was given to 2 patients for 3 weeks and to 3 patients for 7 weeks. 3 responded at least as well to previous therapy; the 4th became almost completely and the 5th entirely seizure free. One patient transferred to 125A after 3 weeks, had prompt exacerbation of seizures during the ensuing 4 weeks, despite dosages up to 4 mg. daily. The 2nd patient transferred to 125A was adequately controlled on this dosage, except for a brief period of paranoid behavior three and a half weeks later; similar episodes had occurred prior to cannabinol therapy. Other psychic disturbances or toxic reactions were not manifested during the periods of treatment. Blood counts were normal. The cannabinoids herein reported deserve further trial in non-institutionalized epileptics. Reprinted from Federation Proceedings, Federation of American Society for Experimental Biology, vol 8, 1949, p.284.
These proceedings demonstrate unequivocally the Anticonvulsant properties of cannabinods. This is not opinion but fact and is therefore "absolute and non-negotiable" in accordance with WP:NPOV. Adding cannabinoids. Alphaquad 22:05, 19 March 2007 (UTC)
replies: text: Tetrahydrocannabinol is not professionally used as an anticonvulsant. It (or related compounds) are being researched as such, along with thousands of other chemicals. This article should not mention all drugs that have some anticonvulsant effect - it would be uselessly long. Colin°Talk 22:08, 19 March 2007 (UTC)
replies: text: Length is not an issue for a single entry. Your persistence shows a biased opinion against this one item and is contrary wiki standards —The preceding unsigned comment was added by Alphaquad (talk • contribs) 22:17, 19 March 2007 (UTC)
replies: text:  Cannabis has well demonstrated anticonvulsant properties; epileptics in Canada have successfully defended their right to use the substance to treat their condition as in the case of Terry Parker. Furthermore, the drug has been used for centuries for this purpose -- its current stigmatized nature in the "Western" medical system does not justify willful ignorance of its effects. Many people are currently using it to successfully treat their condition. It warrants a mention in the article.  —Preceding unsigned comment added by 174.88.178.66 (talk) 19:17, 14 September 2009 (UTC)
thread_title:  Adding for finding of fact 

message: Therapeutic drug monitoring in epilepsy by PN Patsalos, NSE. Has a slightly different set of dates for UK drug introductions. Colin°Talk 21:49, 16 November 2007 (UTC)
thread_title:  Approval dates 

message: I am removing reference [2] and modifiying the sentence that antiepileptics cause cell death. This is wrong and taken out of context. It causes apoptosis in developing neurones, which means the effect is not seen in adult epileptics. I have read the reference and the group were looking at the effects of pregnant women taking AEDs by using postnatal rat models. The information is misleading to the extent that someone is asking about it in Yahoo answers. --Mubinchoudhury (talk) 21:41, 20 May 2008 (UTC)
thread_title:  Apoptosis 

message: This article is currently most a list, rather than sections with prose. I think there are benefits of having a list of such drugs but also of having an article discussing the drugs in general.  Also many modern texts use the term antiepileptic drug (AED) rather than anticonvulsant. So I propose we create two articles:
*Antiepileptic drug - this will be a page-move/rename from anticonvulsant
*List of antiepileptic drugs - this will be a new article containing some of the existing lists from anticonvulsant.
Any objections? -- Colin°Talk 20:53, 24 February 2013 (UTC)
thread_title:  Proposed eorganisation 

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thread_title:  External links modified 

message: Under the bromides section, there is a sentence that starts with "actually" and seems to go against a statement about dogs and cats made above. Can someone with knowledge about this subject clean this up? Thank you. William2001(talk) 05:30, 21 October 2019 (UTC)
thread_title:  Bromides 

message: I am Yaser GHAZAL a student in Üsküdar Üniversitesi in Istanbul Türkiye and Iam taking Special Topics in Neuroscience course with Dr. Öğr. Üyesi AYLA ARSLAN during summer course 2023 and editing this article is part of the tasks assigned to me so i ask for your support Yaser GHAZAL (talk) 11:24, 23 August 2023 (UTC)
thread_title:  Hello everyone