Talk:Tyrosine

message: This discussion has already taken place on the Amino Acid page, so I won't repeat it here. 
Well? This strange caveat should be mentioned in the article (I don't understand it myself, so I'm afraid to edit it in) or there should, at least, be consistency between the two pages. Thanks. --Meta 3:07, 20 Jan 2011 (UTC)
thread_title: Polar/Non-Polar

message: Has anyone ever tried or heard of using tyrosine to help darken the mouth pigment in dogs?
What is the pKa of tyrosine?  This should be listed on the information page.66.42.177.162 (talk) 00:08, 1 April 2011 (UTC)
replies: text: I concur that all pKA's should be listed on every amino acid. Biochemist textbooks do the same. 2A02:8388:1600:6900:BE5F:F4FF:FECD:7CB2 (talk) 09:17, 20 September 2015 (UTC)
thread_title: Questions

message: It'd be nice to see some more information on the metabolic effects in humans. I see this is included in certain energy drinks, so it would be good to know it's effect. The current article has little detail.
You can enhance your vigilance a little bit, if you swallow l-tyrosine pills. 500-1000 g are the right dose.
Tyrosine is changing in adrenalin and melanin. Also it gets metabolize in hormones for the gland of thyroid.
Your blood.pressure gets enhanced! --Fackel 20:47, 30 May 2006 (UTC)
thread_title:  metabolism? 

message: What medical uses are there for tyrosine? I also read that it can promote the division of cancer cells, especially malignant melanoma.
:Not really... since it's an essential amino acid it is absolutely required by the human body. You might be talking about tyrosine kinases, enzymes that make the tyrosine phosphorylated (adds a phosporus). That would be a good article to link to from here. --Antorjal 05:00, 5 September 2006 (UTC)
replies: text: Tyrosine is NOT an EAA. As the article states it's synthesized from phenylalanine. I know this is old but I felt this should be stated so no one gets confused. DriverDan (talk) 18:45, 6 June 2009 (UTC)
replies: text: Tyrosine is very much a conditionally essential amino acid. Basically, any substantial source of stress can make tyrosine very essential. As such, tyrosine and acetyl tyrosine both are popular supplements. Even so, it's useful only if the relevant cofactors for its utilization are handy. --IO Device (talk) 07:05, 5 December 2014 (UTC)

text: I found out that tyrosine helps in nemaline myopathy. I think this info should be added as a medical use. I am looking for the info on such usage but there seems to be no other info except just stating this fact that it helps. But the question is why it helps? Maybe someone has an idea...  — Preceding unsigned comment added by 83.11.125.35 (talk) 23:47, 25 November 2011 (UTC)
thread_title:  Medical usage 

message: The current graphic has something about "enzymatic" hydroxylation to give ortho- and meta-isomers.  I dont know of any evidence for this hydroxylation being directed by enzymatic processes vs some normal free radical degradation.  So I am questioning the validity of the graphic.--Smokefoot 22:21, 22 October 2007 (UTC)
replies: text: * I revised the figure to make it clearer that enzymatic oxidation by phenylalanine hydroxylase only refers to the top reaction.  The second and third arrows refer to free radical oxidation.  I hope this eliminates the confusion.  Cheers. Boghog2 06:54, 23 October 2007 (UTC)
thread_title: Enzymatic hydroxylation to give m- and o- isomers??

message: Suggests (without citation) 100mg/kg per day, then says this is equivalent to 500-1500mg per day. So the average adult wieghs between 5kg and 15kg? Either a typo in the dose or in multiplying the dose up for the daily amount. Also, since it claims that the dose/kg is supported by literature this shouldnt be included without a citation.172.201.254.138 11:37, 1 December 2007 (UTC)
replies: text: That just made it confusing - so I've moved the clinical dose sentence down a bit to make it less confusing. - Rod57 (talk) 06:03, 12 January 2016 (UTC)

text: And I've added {{cn to get some sources. Sadly the article doesnt seem to say anywhere how much we use per day or how much we make each day to compare  with the 500-1500mg/d mentioned. - Rod57 (talk) 06:03, 12 January 2016 (UTC)

text: ... For now I've just noted egg white and lean meats but we need better refs. - Rod57 (talk) 06:40, 12 January 2016 (UTC)
thread_title:  daily dose? 

message: How much do we use per day (and for what) and how much we make each day ?  Is it needed to make thyroxine (as some claim) ? - Rod57 (talk) 06:03, 12 January 2016 (UTC)
thread_title: Metabolic requirements and synthesis 

message: This is just a list - based on differently ordered list on a webpage that doesn't seem to give a ref for the dietary info.
Can we a have a small table with mg/kg or mg/serving for the best sources ? - Rod57 (talk) 06:03, 12 January 2016 (UTC)
replies: text: ... For now I've just noted egg white and lean meats but we need better refs. - Rod57 (talk) 06:40, 12 January 2016 (UTC)
thread_title: Dietary sources

message: I have recently added a line about Cocaine and Tyrosine, suggesting that taking Tyrosine after using Cocaine can reduce the "hangover" and depression effects associated with Cocaine usage
This addition was deleted, and I am not sure why
I have seen it used many times and produce positive results
I believe that this is an important piece of information, and that it is relevant, I was wondering if anybody objects that I will add it again?
it is a problem to talk about Drugs?
Cocaine stimulate the creation of Dopamine. and Dopamine creation uses tyrosine, and the body has limited ability to create tyrosine. Most Cocaine users don't eat regularly, and as a result lack the Tyrosine.
user:Vishvash  —Preceding comment was added at 00:20, 16 January 2008 (UTC)
thread_title:  Cocaine and Tyrosine? 

message: If tyrosine "is found in large quantities in casein," then why is there no mention of tyrosine in the casein article? I think there's a difference between saying that tyrosine is "found in large quantities in casein" and "tyrosine was obtained as a product of the degradation of the protein casein," as the source says. Also, I see no justification for the claim that tyrosine is found in "large quantities" in casein. I'm removing that part immediately. svadhisthana (talk) 20:41, 17 August 2008 (UTC)
thread_title:  Casein 

message: Tyrosine... "has little if any effect on mood.[10][11][12] The effect on mood is more noticeable in humans subjected to stressful conditions"
This contradicts itself.
It is almost like saying "It has no effect on mood. The effect on mood is more noticeable..."
109.153.85.226 (talk) 13:42, 12 March 2012 (UTC)
thread_title:  What? 

message: Tyrosine seems very close to the structure of amphetamine.  It would be interesting to see a study seeing if it has similar effects as amphetamine does.  Havabighed (talk) 06:47, 5 July 2012 (UTC)
replies: text: There isn't really that much of a similarity. In any case, no such study is needed because the effects of both substances are well known already. Tyrosine requires a very high dose, i.e. multiple grams. Even acetyl-tyrosine, which is potent, still needs hundreds of milligrams. Amphetamine requires a much smaller dose. Secondly, unlike amphetamine, regular tyrosine use leads to very rapid development of tolerance to it. Tyrosine works for just a few hours, whereas amphetamine works for many more hours. Tyrosine requires numerous cofactors whereas amphetamine is more independent. Tyrosine is in part used to synthesize dopamine. In contrast, amphetamine in part works by reuptake inhibition of dopamine, i.e. in a remarkably different way. --IO Device (talk) 06:58, 5 December 2014 (UTC)
thread_title:  Comparison with amphetamine 

message: The ball-and-stick representation doesn't seem to tally with the structural depiction. In particular, the bit that's supposed to be NH2 has 3 hydrogens on it.  — Preceding unsigned comment added by 194.39.218.10 (talk) 15:07, 22 October 2012 (UTC)
replies: text: They are two different ways of depicting the same compound.  The first diagram is the typical depiction of an amino acid  - with a neutral amino group and a neutral carboxylic acid.  But since the amino group is a base and the carboxylic group is an acid, in reality the compound is more likely to exist as an ammonium carboxylate, as depicted in the second diagram.  Neither is wrong, but maybe it would be best to use a consistent style for the 2D and 3D representations to avoid this type of confusion.  -- Ed (Edgar181) 15:13, 22 October 2012 (UTC)
thread_title:  Diagrams 

message: Reference #21 (http://www.ncbi.nlm.nih.gov/pubmed/12381742)
Says that Aspartame is used as the placebo.
According to my Google search:
Phenylalanine - University of Maryland Medical Center
www.umm.edu › ... › Complementary Medicine
Aspartame, found in artificial sweeteners such as Nutrasweet, is a source of phenylalanine. People with PKU should not use aspartame. If you are pregnant, ask 
Aspartame contains phenylalanine which turns into Tyrosine. My point is that maybe this study might have used a better placebo and may be biased.
EricStruble (talk) 02:10, 27 February 2013 (UTC)
thread_title:  How good is this study? 

message: Wikipedia thyroid hormones "(T3) and (T4) are Tyrosine-Based hormones produced by the thyroid gland" I think there is some important information here about possible uses other than supporting synthesis of brain neurotransmitters. But I don't see any such information in this article about Tyrosine and Thyroid hormones. Please post a reply I am looking for a Thyroid supplement because thyroid cancer runs in my family.urName (talk) 16:51, 31 July 2013 (UTC)
thread_title:  L-Tyrosine possible uses Thyroid supplement 

message: There needs to be a section on how the Tyrosine Supplements are made. 2602:306:C518:6C40:F04C:9D27:545:1601 (talk) 16:59, 10 January 2014 (UTC)
thread_title:  Commercial Synthesis 

message: There is a 'Betaines' section in the wiki page but no text in it whatever. That's confusing.
108.210.118.83 (talk) 04:57, 2 October 2014 (UTC)
replies: text: I have now removed it.  -- Ed (Edgar181) 12:43, 2 October 2014 (UTC)
thread_title:  Betaine section 

message: What's the molecular formula?
Eg: Phenylalanine has a chemical formula of C9H11NO2 but a molecular forumla of C6H5CH2CHCOOH
~ender 2014-10-06 5:59:AM MST — Preceding unsigned comment added by 71.223.87.212 (talk • contribs) 13:01, 6 October 2014 (UTC)
replies: text: for the condensed formula see here Jytdog (talk) 13:16, 6 October 2014 (UTC)

text: OP posted this on several amino acid pages; please see discussion here: Talk:Tryptophan#Molecular_Formula Jytdog (talk) 14:22, 6 October 2014 (UTC)
thread_title:  Molecular Formula 

message: I think it would be nice if all amino acids have a short article about their "chemical attributes". It is already partially covered such as by stating that it has a more polar -OH group, while still being an aromatic amino acid. 2A02:8388:1600:6900:BE5F:F4FF:FECD:7CB2 (talk) 09:16, 20 September 2015 (UTC)
thread_title:  Chemical Attributes 

message: I added an image of L-tyrosine at physiological pH. I thought this to be more biologically relevant and better suited to learning the amino acids and their structures. I deleted the image of the 3-D structural image. I thought this to be irrelevant and not helpful. I moved the image of the neutrally charged tyrosine to the second box and added the zwitterionic form of tyrosine at the top. I also added captions to the images. AidaGhorbani (talk) 05:29, 10 December 2015 (UTC)
thread_title:  Structures 

message: It should be noted that tyrosine is actually much LESS soluble in water than phenylalanine, due largely to the fact that Tyr's phenolic -OH participates in hydrogen bonding with the carboxyl group. The Merck Index cites these solubility values: Tyrosine – 0.45 mg/mL; Phenylalanine – 29.4 mg/mL.  — Preceding unsigned comment added by 2601:240:C400:1D20:5182:F5FA:5F6A:C22B (talk) 14:24, 6 October 2016 (UTC)
thread_title:  Solubility 

message: As title. Also, from the "Dietary requirements and sources" section, the RDA of phenyl+tyrosine being 42 mg per kilogram contradicts the Phenylalanine page's "Dietary recommendations" figure of "For phenylalanine plus tyrosine, for adults 19 years and older, 33 mg/kg body weight/day" 46.253.188.8 (talk) 12:26, 24 February 2023 (UTC)
thread_title:  Citation 7 is broken link