Talk:Analgesic

message: Needs one or more references for the content, added tag.--FloNight 21:26, 25 November 2005 (UTC)
thread_title:  Needs 

message: There are a number of fact tags in the NSAID/Paracetamol section regarding potential side-effects.  These should all be listed, per FDA regulations in the US, on the product inserts.  How does one cite these, specifically? siafu 22:51, 7 September 2007 (UTC)
thread_title: NSAIDs

message: Can anyone add information about the psychological effects of stimulation-induced analgesia, stress-induced analgesia, and belief-induced analgesia? These are natural effects that, I assume, are simulated by analgesic drugs. My psych prof is saying something about it, and I just missed it. Experts, can you help with this? - 137.122.55.72 17:35, 7 Feb 2005 (UTC)
replies: text: Wikipedia does not answer questions. You'd better go to the reference desk. I wish there were more "experts" on Wikipedia :-) JFW | T@lk 17:49, 7 Feb 2005 (UTC)

text: A lot of the things you mention may be mediated by endorphins, which are the natural ligands for the opioid receptors in the brain. Stimulation, stress and belief may lead to a release of these substances. JFW | T@lk 17:51, 7 Feb 2005 (UTC)

text: I know this talk section is really old but I found some articles that can confirm that stimulants can cause analgesic effects in mice doi:10.1211/0022357001773580. I also found an article that found that "Infusions of 6-hydroxydopamine into the nucleus accumbens abolish the analgesic effect of amphetamine but not of morphine in the formalin test", this means that the analgesic effect is different from opoids. And as a side note  Tricyclic antidepressants often have a stimulant effect.  — Preceding unsigned comment added by Bonnom (talk • contribs) 21:50, 12 April 2017 (UTC)
thread_title: Psychological effects

message: Alcohol doesn't count as a painkiller, does it? —The preceding unsigned comment was added by 207.200.116.198 (talk • contribs) .
:Technically alcohol is an "outdated" painkiller, but it certainly does numb the perception of pain.  --Thoric 15:48, 14 June 2006 (UTC)
thread_title: Alcohol

message: Somebody dumped this from the "Harvard Magazine" site. I cannot disagree with some points raised in that material, though. For example, physiotherapy, behavioral/relaxation techniques and surgery may be used to achieve analgesia. Perhaps we should expand the article to reflect this. JFW | T@lk 14:31, 17 July 2006 (UTC)
thread_title:  Copyvio 

message: I did some minor copyedits, but this section needs more edits relying upon subject-matter knowledge that I lack. Here are some suggestions.
Section heading. The section heading is awkward (see WP:MOS#Slashes and its subordinate section on "and/or"), and might not even need to use both adjectives. If "atypical analgesics" and "adjuvant analgesics" are synonyms, as the body text seems to imply, then use one of those terms in the heading and explain the alternate name in the body text. Thus, the section heading could be, simply, Adjuvant analgesics, and the body text could begin with "Adjuvant analgesics, also called atypical analgesics, ...". If those terms are not synonyms, then the heading could be, Atypical and adjuvant analgesics; however, there is no explicit reference to atypical analgesics in that section now, so additional editing would be needed to identify those drugs that are already included from that category, or to add them to the section, or to drop that adjective from the heading.
Run-on sentence. The first sentence is overly complex and appears to be serving two purposes: a list of drugs in one or both categories; and a description of their usage. So, it should be split up. For example, the revised wording could be, Adjuvant analgesics, also called atypical analgesics, include orphenadrine, cyclobenzaprine, scopolamine, atropine, gabapentin, first-generation antidepressants and other drugs possessing anticholinergic and/or antispasmodic properties. These drugs are used in many cases along with analgesics to potentiate centrally acting analgesics such as opioids when used against pain--especially of neuropathic origin--and to modulate the effects of many other types of analgesics by action in the parasympathetic nervous system.
Inconsistency. The first sentence about THC ascribes to it an "indisputably true benefit" that "may be" its superior anti-nauseant action. If we can say only "may be", then we can hardly describe that benefit as indisputable. Also, "indisputably true benefit" is redundant; "indisputable benefit" is sufficient.
I think there may be a couple of problems in the logic of the sentence structure in the Addiction section, too, but I'll stop here for now.
My 2¢ worth. --rich<Rich Janis 02:04, 27 July 2007 (UTC)
thread_title:  Atypical and/or adjuvant analgesics 

message: doi:10.7326/M14-2559 JFW | T@lk 13:23, 13 January 2015 (UTC)
thread_title:  Review of opioids 

message: === External links modified ===
Hello fellow Wikipedians,
I have just added archive links to  on Analgesic. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20101019055341/http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm054718.htm to http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm054718.htm
*Added archive https://web.archive.org/20140413144556/http://www.mhra.gov.uk/Safetyinformation/Generalsafetyinformationandadvice/Product-specificinformationandadvice/Product-specificinformationandadvice-A-F/CardiovascularsafetyofCOX-2inhibitorsandnon-selectiveNSAIDs/ to http://www.mhra.gov.uk/Safetyinformation/Generalsafetyinformationandadvice/Product-specificinformationandadvice/Product-specificinformationandadvice-A-F/CardiovascularsafetyofCOX-2inhibitorsandnon-selectiveNSAIDs/
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
Cheers. —cyberbot IITalk to my owner:Online 20:15, 15 October 2015 (UTC)
thread_title: Bot maintenance

message: Hello fellow Wikipedians,
I have just added archive links to  on Analgesic. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20101019055341/http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm054718.htm to http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm054718.htm
*Added archive https://web.archive.org/20140413144556/http://www.mhra.gov.uk/Safetyinformation/Generalsafetyinformationandadvice/Product-specificinformationandadvice/Product-specificinformationandadvice-A-F/CardiovascularsafetyofCOX-2inhibitorsandnon-selectiveNSAIDs/ to http://www.mhra.gov.uk/Safetyinformation/Generalsafetyinformationandadvice/Product-specificinformationandadvice/Product-specificinformationandadvice-A-F/CardiovascularsafetyofCOX-2inhibitorsandnon-selectiveNSAIDs/
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
Cheers. —cyberbot IITalk to my owner:Online 20:15, 15 October 2015 (UTC)
thread_title:  External links modified 

message: Hello fellow Wikipedians,
I have just added archive links to  on Analgesic. Please take a moment to review my edit. If necessary, add  after the link to keep me from modifying it. Alternatively, you can add  to keep me off the page altogether. I made the following changes:
*Added archive https://web.archive.org/20140408211938/http://journal.nzma.org.nz/journal/119-1230/1875/content.pdf to http://journal.nzma.org.nz/journal/119-1230/1875/content.pdf
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thread_title:  External links modified 

message: === No history of analgesics? ===
I came here looking for the history of analgesics and didn't find what I was looking for after a quick glance at the article.  Why is there not a section on it?  —Preceding unsigned comment added by 173.53.180.137 (talk) 15:00, 18 November 2010 (UTC)
thread_title: Social issues

message: I came here looking for the history of analgesics and didn't find what I was looking for after a quick glance at the article.  Why is there not a section on it?  —Preceding unsigned comment added by 173.53.180.137 (talk) 15:00, 18 November 2010 (UTC)
thread_title:  No history of analgesics? 

message: 124.254.78.121 (talk) 05:33, 2 November 2011 (UTC)
thread_title:  No section on why people are addicted to painkillers 

message: === Difference between analgesic and anesthetic? ===
What is the difference between an analgesic, and an anesthetic (especially a local anesthetic where consciousness is not impaired)? Would drugs such as the well known -caines (lidocaine, novacaine) count as anesthetics, alagesics, or both?
FT2 (Talk | email) 00:54, 20 November 2008 (UTC)
thread_title:  Clarification needed 

message: What is the difference between an analgesic, and an anesthetic (especially a local anesthetic where consciousness is not impaired)? Would drugs such as the well known -caines (lidocaine, novacaine) count as anesthetics, alagesics, or both?
FT2 (Talk | email) 00:54, 20 November 2008 (UTC)
thread_title:  Difference between analgesic and anesthetic? 

message: Isn't there enough usage to putatively show a perfunctory fiat upon the current idiom where Pain relievers are NSAIDs (prodrugs to cannabinoid receptor agonists and cannabinoids as direct agonists too) and such, whereas Pain killers are opiate or opioid narcotics a la mu-receptor agonists? 67.171.248.22 (talk) 04:57, 9 September 2010 (UTC)
thread_title:  Pain-reliever versus Pain-killer 

message: There is nothing on shortwave diathermy or RF analgesics in general.  Could someone correct this?  — Preceding unsigned comment added by 2.100.65.56 (talk) 08:03, 5 August 2012 (UTC)
thread_title:  No Section on Radio-Based Painkillers 

message: SO I came to this article fro another Wiki article to find what out what an "analgesic" is. From the article: "Analgesic drugs act in various ways on the peripheral and central nervous systems. They are distinct from anesthetics, which reversibly eliminate sensation,". From this sentence it seems to me that analgesics and anesthetics do the exact same thing unless anesthetics act *only* locally. Even if that is the case, aren't pain nerves part of the peripheral nervous system? 
I know absolutely nothing about biology and I am not getting a clear definition from the article so if someone could clear that up, I think it would help out the article (and the ignorant like me) a lot. Thank you.173.180.7.3 (talk) 10:54, 25 July 2013 (UTC)
thread_title: Analgesic vs Anesthetic

message: Currently this article is titled "analgesic". "Analgesia" also redirects here. I think that "analgesic" is a name used by health care professions and not layman consumers. Because of this, I think this article's title should be changed to the WP:COMMONNAME. Here are some alternatives:
*Pain medication
*Pain reliever
*Painkiller
*Does anyone know others?
About 2000 Wikipedia articles have links to this article, so the name should be thoughtfully chosen.
Here are some examples of names that some other organizations use. I do not think these uses reflect any choice for an organization manual of style, but rather, these examples are just what the organizations used in these articles. Elsewhere they might use another name for the same concept.
*Pain relievers - MedlinePlus
*Painkiller - NHS Choices
*pain medication - Mayo Clinic
*painkiller - Centers for Disease Control and Prevention
Looking in Wikidata, the equivalent Wikipedia article in other languages is often called "analgesic".
I just did searches in Google Scholar. The following searches got the following numbers of hits.
*analgesic - 813,000
*"pain medication" - 69,200
*"pain reliever" - 13,000
*painkiller - 18,300
*"pain killer" - 11,700
I just did searches in general Google search. The following searches got the following numbers of hits.
*analgesic - 11,500,000
*"pain medication" - 870,000
*"pain reliever" - 452,000
*painkiller - 13,100,000 (top hits are unrelated to drugs for pain relief)
*"pain killer" - 433,000
Most instances of use overall favor "analgesic". However, from what I see, publications for consumers favor using terms other than analgesic.
Thoughts from others? Who prefers which name?  Blue Rasberry (talk) 18:52, 27 July 2016 (UTC)
thread_title: Rename proposal

message: In April 2014  added a massive, brilliant table to this article called "Comparison of Available agents". See it live at Analgesic#Comparison_of_available_agents. I like the table a lot but I am unsure if the best place for it is here. It might be.
Here are some options I am considering -
#Leave it here
#:If it is left here, it needs an introduction somehow. I do not think that it attracts enough attention to itself without having 2-3 sentences introducing it. Also, if it does stay here, it should get a categorized redirect so that it can appear in in category lists including :Category:Medical comparisons. I think this could be a model for other drug comparisons. It would be worthwhile to link several articles to this list, like for example, every drug class in the list should link here.
#Spin it off into its own single article
#:This is a tremendous amount of content and it could be managed in its own article. This much content usually is placed in a list article, just because of the style of Wikipedia. Additionally, if it were in its own article, it would not need to be collapsed and it would be easier to make other Wikipedia articles link to different sections of this list.
#Do either of the above, but also duplicate parts of the list elsewhere
#:This is a bad idea because Wikipedia should not WP:FORK content. It is better to have any list only in one place. However, some how in some way, portions of this list need to be made available for other articles. Like for example, Non-steroidal anti-inflammatory agents needs to link to its own section in this list.
#Spin this off into multiple other lists
#:I think this is a bad idea also, but there is so much content here that that this chart could be separate articles called "list of NSAIDS" and "list of COX-2 inhibitors" and the rest.
I think that I favor moving this into its own article. In addition to that, the drug classes listed here each need a section in their articles which describes the list and then links to it.
*Nonsteroidal anti-inflammatory drug
*COX-2 inhibitor
*Opioid
*I suppose there is no particular article which should link to the "Other analgesics" section
I am not in any hurry to do anything. Right now I am just thinking. It could just stay where it is, and I suppose since this is the high-traffic article this is a natural place for it. I just wonder if this content would be more prominent if presented in its own space and not collapsed. Thoughts from anyone?  Blue Rasberry (talk) 19:36, 27 July 2016 (UTC)
replies: text: believe #1 is best leave it here (and do the redirect)--Ozzie10aaaa (talk) 23:23, 27 July 2016 (UTC)
replies: text: I'm fairly easy either way, though I do agree it should have its own space and not just be collapsed, thanks for the pats on the back though, at times it seems like all my edits do is cause people to get ticked off, it's nice to be reminded that people appreciate my work at times. Brenton (contribs · email · talk · uploads) 02:18, 28 July 2016 (UTC)
thread_title: "Comparison of available agents"

message: Wikipedia is sensitive to WP:COI so I wanted to post notice that I added a link to one of my employer's publications to the external links section. There were no external links previously. Please discuss further if needed at Talk:Pain_management#spam_for_my_employer_-_added_external_link, where I discuss adding the same link to the pain management external links section. Thanks.  Blue Rasberry (talk) 21:07, 29 July 2016 (UTC)
replies: text: Thanks for acknowledging the COI, but I would suggest using Suggested Edit in a case like this. Nice resource, but a lot of ads. Mixed feelings about whether it adds value. — soupvector (talk) 22:25, 29 July 2016 (UTC)
replies: text: I removed the link and made a request for the "suggested edit" coi process at Talk:Pain_management#spam_for_my_employer_-_added_external_link. Thanks for the feedback. I went further on that talk page and linked some comparable resources provided by other organizations. I hope that gives context to what resources are available to people who search for such information.  Blue Rasberry (talk) 16:42, 1 August 2016 (UTC)
thread_title: Spam for my employer

message: https://en.wikipedia.org/w/index.php?title=Analgesic&oldid=760575810 "have been derived from" is clunky language. It seems that it is written by someone who knows english as a second language. 162.231.134.145 (talk) 02:00, 18 January 2017 (UTC)
thread_title:  why  did someone undo this edit? 

message: The Classification section introduces itself with the sentence "Analgesics are typically classified based on their mechanism of action." Good idea. Do we have a taxonomy of mechanisms of action? Well, not in this article. How about reference 4, the BNF online link? It redirects to https://about.medicinescomplete.com/, which conveys that BNF is a very exclusive organization of some sort. OK, how about by example in the various subheadings? The first subheading is acetaminophen, that's a chemical not a mechanism of action. OK, as a last resort, let me take a stab at what the mechanisms of action might be. The first is to prevent pain from arising in the first place, e.g., by reducing inflammation. The last is to prevent the brain from finding out about it. An intermediary strategy might be to stop the central nervous system from finding out about it. Somewhere in all of this, we should see the term "antinociception," but we don't, I find that odd. The subheadings for this section suggest that the classification used is mainly historical. Perhaps the easy fix would be to replace the first sentence of this section with a more accurate overview of what is to follow. Page Notes (talk) 20:20, 26 February 2019 (UTC)
thread_title:  Classification by mechanism of action?