Talk:Adrenaline/Archive 1

message: It seems like more could be said about the physiological effects of epinephrine, but I was reading various issues of an anaesthesiology journal once and much mention was made of epinephrine as a resuscitative and/or post-operative aid. Also, if I recall correctly, the concentrations of epinephrine involved were very small, so maybe a note on its power (signal cascading?) could also be added. I'd put this stuff in myself but it's not my field. I'll try to look it up again if no one else responds though. Jeeves 15:53, 15 Apr 2005 (UTC)
thread_title:  Use in anaesthesiology? 

message: Adrenaline or Epinephrine, as far as I know, is NOT a neurotransmitter, nor is it realease by neurones. it is a hormone released by the adrenal gland (thus its name) and it is relase into the blood stream, not a synaptic cleft.
I think the author may have confused it with Noradrenaline (which IS a neurotransmitter released by neurones).
: Epinephrine is both a hormone and a neurotransmitter. Such duality is common.
: Epinephrine, together with dopamine and norepinephrine, for the group of neurotransmitters called catecholamines.
: As for production, one mechanism is based on the transportation of tyrosine to catecholamine-secreting neurons. where a series of reactions convert it to dopamine, to norepinephrine and finally to epinephrine.
: In summary: both norepinephrine and epinephrine are neurotransmitters.Peak 01:50, 12 November 2005 (UTC)
thread_title:  Mistake in info? 

message: --Ddhix 2002 03:51, 21 March 2006 (UTC)
replies: text: http://www.erowid.org/archive/rhodium/chemistry/adrenochrome.txt This file may help you.--Ddhix 2002 03:51, 21 March 2006 (UTC)

text: Or you could check out adrenochrome. Deli nk 20:07, 10 May 2006 (UTC)
thread_title:  adrenocrome 

message: I came here looking to learn more about the hormone's effect on muscle performance, pain tolerance, reaction time, etc. I've heard stories of it granting incredible strength, even allowing children to lift cars off of loved ones being crushed to death. Is there any truth in this? Can anyone find more info on this stuff? The Taped Crusader 06:22, 10 April 2006 (UTC)
thread_title:  what about the effects of epinephrine on people's performance? 

message: How is it called in Canada, the U.K. and Australia? If they, as the article suggests, call it "Adrenaline" then the main name used should be "Adrenaline" rather than "Epinephrine", or this article would be guilty of US-centrism. This is an English encyclopedia, not one for a specific country.
--A Sunshade Lust 19:00, 9 July 2006 (UTC)
replies: text: UK moved several years ago to adopt WHO INNs. As such correct term worldwide and in UK is Epinepherine. Given though importance of thi drug, it is permitted to also use term Adrenaline. Article correctly, as far as UK usage goes, is epinepharine (not adrenaline). In general discussion though one talks about "adrenaline rush", "adrenaline junkies" (i.e. extreme sports fans), "adrenal gland" etc. David Ruben  Talk  19:26, 7 August 2006 (UTC)
thread_title:  Adrenaline vs. Epinephrine 

message: Epinephrine is a vasoconstrictor. However, in the "Pharmacology" section it says: 
<Blockquote>Epinephrine also activates β-adrenergic receptors of the liver and muscle cells, thereby activating the adenylate cyclase signaling pathway, which will in turn increase glycogenolysis. Specifically, β2 receptors exist on many blood vessels. Activation of the adenylate cyclase pathway on this tissue causes inhibition of myosin light chain kinase which, in turn, relaxes the smooth muscle cells of the blood vessel walls to bring about vasodilation.</Blockquote>
This is either wrong or just confusing. Can someone edit the text to clear up why epinephrine is a vasoconstrictor and yet the pathway it activates causes relaxation of smooth muscle cells of the blood vessel walls to bring about vasodilation?
::Adrenaline is both a vasoconstrictor and vasodilator depending on receptor subtype and thus second messenger system. --Coroebus 18:34, 15 July 2006 (UTC)
thread_title:  vasoconstrictor vs vasodialator 

message: In the section "Pharmacology"
Someone wrote in "This is wrong..." and gave another explaination.  I'm not sure which is right or how to fix this.  Maybe a biochemist can sort it out.
74.60.29.249 04:59, 15 October 2006 (UTC)
thread_title:  Contradiction