Talk:Benzalkonium chloride

message: Why no information on laboratory methods for synthesis/analysis?  — Preceding unsigned comment added by 2601:193:C400:621:B482:34BF:EEBD:8332 (talk) 13:37, 4 April 2020 (UTC)
thread_title:  Synthesis 

message: 50ml of a 50% solution in a 4000 litre fishpond killed all goldfish within hours. Some waterlilly leaves are turning yellow but I'm not yet sure if this chemical is the cause.
"The substance is very toxic to aquatic organisms." 
(67.171.24.88 20:41, 31 March 2007 (UTC)
replies: text: 50g in about 4000 L of solution? About 12.5 mg/L, which is well above the EPA's LC50 for fish of 280 micrograms per liter. (http://www.epa.gov/oppsrrd1/REDs/adbac_red.pdf). --SV Resolution(Talk) 18:53, 30 March 2009 (UTC)
thread_title:  Caution 

message: "Zephiran" redirects here, but that name does not occur in the article even once.  —Preceding unsigned comment added by 85.101.1.17 (talk) 18:58, 10 November 2007 (UTC)
thread_title:  Redirection 

message: So perhaps benzalkonium chloride is the explanation for the ill-health effects of Zicam.  The following from a search of the Zicam site for "benzalkonium chloride" on June 17, 2009 (when the news of Zicam's ill-health effects came out):
"Extreme Congestion Relief Nasal Gel
... are: Alkoxylated diester, Aloe barbadensis gel, Benzalkonium chloride, Benzyl alcohol, Disodium EDTA, Disodium phosphate, ...
http://www.zicam.com/node/247
Intense Sinus Relief Nasal Gel
... are: Alkoxylated diester, Aloe barbadensis gel, Benzalkonium chloride, Benzyl alcohol, Disodium EDTA, Disodium phosphate, ...
http://www.zicam.com/node/248 
Elsewhere on the web, the ingredients are listed as: 
Active Ingredients: Zincum Glucoincum* 2x
Inactive Ingredients: Benzalkonium chloride, glycerine, hydroxyethlycellulose, purified water, sodium chloride, and sodium hydroxide.
—Preceding unsigned comment added by 66.167.95.48 (talk) 23:45, 17 June 2009 (UTC)
thread_title: Ill-health effects of Zicam explained by benzalkonium chloride? 

message: This chemical is being marketed as a lotion to treat Fungal infections of finger nails and toe nails. i would like to know if there are any medical reports about its effectiveness and usage.
Ashok Mogre 4th June 2004
what happens if swallowed?  —Preceding unsigned comment added by 68.165.11.197 (talk) 00:49, 3 May 2010 (UTC)
thread_title:  marketing as treatment for finger nail fungal infections  

message: Many mass-marketed inhaler and nasal spray formulations contain benzalkonium chloride despite substantial evidence that it interferes with function of the cilia of the respiratory epithelium
66.167.61.217 (talk) 21:05, 23 May 2010 (UTC)
thread_title:  Many mass-marketed inhaler and nasal spray formulations contain [[benzalkonium chloride]] despite substantial evidence that it interferes with function of the [http://en.wikipedia.org/wiki/Respiratory_epithelium#Mucociliary_Escalator cilia] of the [[respiratory epithelium]] 

message: The first paragraphs read like advertising copy (eg. "As the antiseptic in Bactine, benzalkonium chloride has been used safely for decades on childhood scrapes and cuts.") while the Safety section has serious concerns.
Also, it's an elaborate-tense double negative to say "it has the advantage of not burning when put on a wound, which is not the case with ethanol-based antiseptics or hydrogen peroxide" (just helping here, "an advantage of benzalkonium chloride has not currently been shared by ethanol-based antiseptics or hydrogen peroxide antiseptic which is when burning was not the case without application to unbroken skin by one").  — Preceding unsigned comment added by 24.78.10.84 (talk) 05:50, 8 November 2011 (UTC)
thread_title:  Commercial 

message: An iced solution of benzalkonium chloride can be used to treat hydrofluoric acid burns (see this document).  — Preceding unsigned comment added by 93.146.170.178 (talk) 09:20, 23 February 2012 (UTC)
thread_title:  Treatment of HF burns 

message: Beule AG (Achim G. Beule)
Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2010; 9: Doc07.
Published online 2011 April 27. 
 [Free full text]
 
:Abstract
:In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.
... 
:Decongestants used to have benzalkonium chloride as a preservative. This quartery ammonium compound is capable of destroying cell walls of microorganisms. In-vitro, toxic effects on cilia [252], deterioration of granulocyte chemotaxis and phagocytosis [256] and of neutrophil defense [257] have been reported. Because benzalkonium chloride aids development of drug-induced rhinitis [253], [258], aggravates its symptoms [241], [259] and may provoke rhinitis medicamentosa if used alone [260], only a few formulations in Europe are still available containing benzalkonium chloride [240].
:Structural changes in rhinitis medicamentosa include damage and loss of cilia [261], metaplasia [261] and epithelial oedema [262], tears in the basal membrane [261] and openings in subepithelial endothel [250], [261] together with vasodilatation [241]. Moreover, hyperplasia of goblet cells [251], [262] and infiltration of inflammatory cells [263] were demonstrated probably as equivalent of reparative changes with increased expression of epithelial growth factor [263]. As complication, septal perforation may occur [264]. If not adequately treated, this disease leads to secondary atrophic rhinitis up to frank clinical picture of ozaena [265].
Author information ► Copyright and License information ▼
Copyright © 2011 Beule
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited. 
+++++++++
--Ocdnctx (talk) 01:29, 4 June 2012 (UTC)
thread_title:  2010 review undercuts claims of benzalkonium chloride safety 

message: FDA-approved Viroxyn's Active Ingredients are Benzalkonium Chloride 0.13% and Benzocaine 5% (source)
and they're available inexpensively (non-RS source).  It's most effective against HSV-1 (journal article) - better than Abreva, and Famivir.  So perhaps it should be mentioned a bit more prominently? --Psrq (talk) 20:34, 15 November 2012 (UTC)
thread_title: as Viroxyn

message: This article lists BZK as incompatible with soaps and similar. However, it seems to be included in some soap-like forumations. This article does not have a citation for this claim. The same claim appears elsewhere on the web, but I have not seen it cited. It also appears many of those claims copied the text directly from this article.
If anyone has any information on this, either way, that would be a good addition to the article. (Also, I'd really like an answer myself.)
Evand (talk) 15:18, 12 May 2014 (UTC)
thread_title:  Soap incompatibility 

message: Could somebody who understands the chemistry update the article to explain why there's only even-length alkyl chains.  Do odd-length chains have some kind of incompatible properties, or are they just harder to synthesize, or ....?
:You're on the right track with "harder to synthesize".  In terms of commercial availability, most long alkyl groups used in industrial chemistry are derived from natural fatty acids.  Fatty acid biosynthesis involves successively stitching together two-carbon pieces, so most fatty acids have an even number of carbon atoms.  Therefore alkyl groups with an even number of carbon atoms are simply more readily available.  -- Ed (Edgar181) 22:04, 3 October 2014 (UTC)
thread_title:  Why even-length alkyl chains? 

message: Looking for the relevant information from these texts:
Grant WM, Schuman JS. Toxicology of the eye (4th Edition). Charles C Thomas Publisher Ltd, Springfield, IL, USA, 167 (1993)
Clinical Toxicology of Commercial Products: Acute Poisoning, ed. 3, by Marion N. Gleason, M.Sc., Robert E. Gosselin, M.D., Ph.D., Harold C. Hodge, Ph.D., D.Sc., and Roger P. Smith, Ph.D. Baltimore: The Williams and Wilkins Co., 1969
ISBN 10: 0683036602 / 0-683-03660-2 
ISBN 13: 9780683036602
Publisher: Lippincott Williams & Wilkins,US
If you can assist please email me via the link in your page update notification. WitheredLimb (talk) 22:03, 4 November 2014 (UTC)
thread_title:  Looking for information 

message: Substituted at 09:27, 29 April 2016 (UTC)
thread_title: Assessment comment

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thread_title:  External links modified 

message: An editor has identified a potential problem with the redirect :CH3CH2Cl and has thus listed it for discussion. This discussion will occur at Wikipedia:Redirects for discussion/Log/2022 January 14#CH3CH2Cl until a consensus is reached, and readers of this page are welcome to contribute to the discussion.  ~~~~User:1234qwer1234qwer4 (talk) 21:46, 14 January 2022 (UTC)
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