Talk:Dose–response relationship

message: The maximum concentration of anything in anything is less than 100 Molar, so the plot's x-axis going out to 10,000 Molar is a bit much. For reference, the concentration of water in water is about 55.5 molar and that is a reasonable maximum upper limit for concentration in an aqueous environment. The EC50 of 0.7 molar would correspond to 140 grams/liter (14% w/w) of a typical 200 molecular weight drug or toxin. That would be about 9.8 Kg evenly distributed in a 70 KG body weight person.
Perhaps should relabel the x-axis as millimolar or micromolar and change the text to match.
--Jsluka (talk) 21:25, 6 February 2022 (UTC)
thread_title: Physical impossible concentrations on the dose response curve

message: The link at the bottom of the page doesn't appear to work, wonder if it might be updated
cheers
"These inconsistencies can challenge the the validity of judging causality solely by the strength or presence of a dose-response relationship". Seems to me that if you get a dose-response relationship in an experiment, causality holds. Could anybody explain more on this point? Thanks.   —Preceding unsigned comment added by 128.151.71.18 (talk) 13:24, 9 April 2008 (UTC)
thread_title: Untitled

message: The slopes of the linear sections of the two dose response curves are almost identical. A casual glance could lead a reader to think that, while the curved ends differ, the slopes are supposed to be the same. Unless this is intentional, it would be useful to have an example that left no doubt as to whether the slopes should be the same or may differ considerably. 89.243.38.33 (talk) 20:02, 20 June 2009 (UTC)
thread_title: Misleading dose response curve graphic

message: Dose-response relationship already introduces all the concepts required to truly understand the concept of an effective dose. I am not convinced that the Effective Dose article is really going to grow much beyond a dictionary definition as all historical, etc information will likely be duplicated from dose-response. -- cmhTC 17:38, 26 October 2006 (UTC)
replies: text: "These articles should be merged as Effective dose ... deserves its own page"?  Doesn't that mean that it shouldn't be merged?  Also, wouldn't it be possibly more helpful to merge EC50 into Effective dose, than Effective dose into here? --PhiJ 13:51, 24 February 2007 (UTC)
thread_title: Merge [[Effective dose]] and [[Dose-response relationship]]

message: Would be nice if somebody covered this as the article suggests that all dose-response curves have thresholds.--Santahul 12:47, 5 January 2007 (UTC)
thread_title:  No-threshold curve 

message: The information regards medical physics should be kept under the title effective do[s]e, as this what it is called by the International Commission on Radiological Protection.
: No longer in article - not sure why. - Rod57 (talk) 14:22, 20 December 2015 (UTC)
thread_title:  Medical Physics 

message: The graph on this page shows the fraction of receptors bound with changing agonist concentration.  This is not what a dose-response curve illustrates.  Dose-response curves relate the concentration of agonists (or antagonists) to a biological effect (ie. rate of enzymatic action).  Receptor occupancy does not necessarily correspond to enzyme activity, as the maximal biological function of most cellular processes are achieved well below 100% occupancy.
:It is true that the figure, as labeled, is not a dose-reponse curve.  However, the y-axis could just as well read "response", in which case it would be appropriate.  Also, the labels potency and efficacy on the figure are not sufficiently explained/discussed in the article.  I don't have a figure that would immediately fix these issues, but I might be able to get/make one, eventually.  Meanwhile, anyone else with one should feel free to replace it. Shanata (talk) 09:15, 22 March 2009 (UTC)
thread_title:  Problem with Figure 

message: Article only seems to cover undesirable responses. Should we include the desire for a dose-response effect in a new drug - or is that covered in another article? Currently dose-response effect redirects to this article. - Rod57 (talk) 14:26, 20 December 2015 (UTC)
thread_title:  Should this article also cover dose-response effect for drugs desired responses 

message: Article says "A commonly used dose-response curve is the EC50 curve, the half maximal effective concentration, where the EC50 point is defined as the inflection point of the curve". Both the first and last thirds of that sentence seem wrong.  EC50 is a point or single value, not a curve, and it is not defined as the inflection point of the curve. - Rod57 (talk) 17:59, 30 April 2016 (UTC)
thread_title:  EC50 description seems wrong 

message: Hello!
I have written a draft on "dose-effect" but it has been declined by a reviewer. He has asked me to start a discussion here about whether technically "dose-effect" and "dose-response" should be separate terms or whether dose-effect relationship should be redirected to dose-response or made a section in dose-response. Please pour in your thoughts on this topic and help me out here. I really appreciate your input! Thanks.
My draft:
Draft:Dose_Effect
Here are some clarifications from my end:
Both the terms are similar but not necessarily synonymous. Let me explain how:
:Dose-response can be defined as "The relationship between the amount of exposure [dose] to a substance and the resulting changes in body function or health (response)." 
:On the other hand, dose-effect can be defined as "The relationship between the dose of harm-producing substances or factors and the severity of their effect on exposed organisms or matter." 
:Dose-response is used to describe how a substance stimulates a (biological or biochemical) response in an organism. This substance could be beneficial or toxic for the organism. Alternatively, dose-effect is used to describe the severity of a toxic substance's harmful effect.  
I believe we can add a section in the dose-response article about dose effect and internally link both the articles together. Would love to hear your thoughts on this! Amandawil (talk) 16:55, 29 September 2021 (UTC)
replies: text:  Pinging Wikipedia:WikiProject Pharmacology, Wikipedia:WikiProject Medicine/Toxicology task force, and folks at Talk:Dose (biochemistry) AngusW🐶🐶F (bark • sniff) 17:38, 29 September 2021 (UTC)
replies: text: In the usual practice of science analysis, there's no difference, and dose-effect certainly doesn't always mean harm-producing - that was a context for environmental statistics, as the source shows. Zefr (talk) 23:37, 6 February 2022 (UTC)
thread_title:  Difference between "Dose-Response" and "Dose-Effect" 

message: Example side graph is weird.
Why doesn’t the response start at 0%?
Why is there about a 10% response without any stimulation? 103.247.195.70 (talk) 15:21, 16 May 2023 (UTC)
thread_title:  Graph of dose-response starts at 10% response not 0%