Talk:Muscarinic acetylcholine receptor

message: Hello. the agonists and antagonists listed in the table should be more specific to the receptor, otherwise it makes no sense and we can simply write Acetyl choline in each one. So I've inserted specific agonists and antagonists for each receptor.vineetcoolguy 12:30, 19 August 2007 (UTC)
replies: text: I would like to see the the affinity each agonist and antagonist has on each of the muscarinic receptor types.  I don't simply want to know if an agent has an effect, I want to know how effective each of these agents are.  I want to see how selective certain agents are on various receptors.  Stephen Charles Thompson (talk) 03:01, 14 January 2013 (UTC)
thread_title:  Agonists and antagonists - go specific 

message: The sentence which reads "atorpine (to dilate the pupil) should be changed. Although atropine can and was once used to dilate the pupil in earlier times for cosmetic reasons, it is no longer used for this application and we realise the dangers of doing so. It should be noted there however that atropine is used in the clinic, especially emergency medicine where it is used to block the effects of organophosphate poisoning, increase heart rate and cardiac contractility and increase blood pressure. It is named on the World Health Organisations list of essential drugs for the emergency department resuscitation room.  —Preceding unsigned comment added by 152.78.249.51 (talk) 10:38, 15 March 2009 (UTC)
thread_title:  "Atropine (To Dilate The Pupil)" 

message: Due to the fact that atropine has overwhelmingly been replaced as the anticholinergic of choice for prevention of neostigmine induced bradycardia, it should be included for completeness.  There are articles (Ramamurthy et. al., 1972; Klingenmaier et. al., 1972; Mirakhur et al., 1981; etc...) in the literature dating back to the early 1970s citing the advantages of glycopyrrolate over atropine for reversal of neuromuscular blockade. Until it is included, this article is incomplete.24.178.161.29 (talk) 01:09, 31 March 2011 (UTC)
thread_title:  There is no mention of glycopyrrolate (Robinul) anywhere in the article 

message: Seriously people. A mushroom? Can someone find a better image that can be used as a visual representation of a Muscarinic acetylcholine receptor?
--68.38.75.142 (talk) 15:28, 26 October 2012 (UTC)
replies: text: The mushroom is a perfect symbol.  It has historical significance as being one of the first known external sources of acetylcholine and our awareness of a parasympathetic system in the human body.  Our stone-age ancestors may not have had specific concepts about Muscarinic receptors or cranial nerves but they did know the very specific effects of this mushroom, and the opposite effects of the antagonists found in Henbane, Jimsonweed / Datura, Belladonna / Nightshade. Stephen Charles Thompson (talk) 00:14, 14 January 2013 (UTC)
thread_title:  A mushroom? 

message: Hyoscscyamine is a notable muscarinic antagonist like atropine yet it is not referenced here.  The Hyoscyamine article states that "at comparable doses, hyoscyamine has 98 per cent of the anticholinergic power of atropine", but no citation is provided.  If someone (including myself) were to find a reference for this, we should update both of these articles accordingly. Stephen Charles Thompson (talk) 23:59, 13 January 2013 (UTC)
replies: text: The best I have been able to dig up are pharmaceutical references like this one, presumably prepared for insertion in prescription fulfillments. 
  Note: this is released according to the freedom of information act.
It states that it is an anticholinergic agent.  It does not specifically state which receptor type it acts upon but does infer this information by describing the sites where the effected receptors are.
"Hyoscyamine sulfate inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, and the exocrine glands. At therapeutic doses, it is completely devoid of any action on autonomic ganglia. Hyoscyamine sulfate inhibits gastrointestinal propulsive motility and decreases gastric acid secretion. Hyoscyamine sulfate also controls excessive pharyngeal, tracheal and bronchial secretions." Stephen Charles Thompson (talk) 03:26, 14 January 2013 (UTC)

text: This description specifically coincides with M1, M2, M3 receptors.  I am unable to make any connection between this description and M4 or M5 receptors and have therefore omitted them.  Anyone out there have a scientific journal to back this up?  Stephen Charles Thompson (talk) 03:47, 14 January 2013 (UTC)
thread_title:  Hyoscscyamine 

message: Could anybody find a source for this article's claim that the M2 receptor mediates a "recovery" via hyperpolarisation of postganglionic cells in the autonomic ganglia? (Or even that M2 is localised to autonomic ganglia?)
As for M1-mediated slow EPSP in the autonomic ganglia, the only reference appears to be a faculty website at the University of Toledo that has since been taken down. Anybody able to find primary literature for this?
This uncited (and potentially misleading) information has been in this article for almost as long as it has existed.
And the remainder of the section on "recovery receptors" consists almost exclusively of nonspecific information about the cholinergic system and autonomic NS; I do not believe it belongs in this article.
134.173.78.1 (talk) 07:06, 8 October 2014 (UTC)
thread_title:  Unsourced information - M1 and M2 in autonomic ganglia - "Recovery receptors" 

message: Substituted at 00:38, 30 April 2016 (UTC)
thread_title: Assessment comment