Talk:Neuroleptic malignant syndrome

message: I think NMS can also be caused by withdrawal from Sinemet, but I don't know enough about it to make the edit.  Can a physician or other expert comment?
 Sarah Waggoner 21:21, 26 September 2007 (UTC)
thread_title:  NMS and Sinemet withdrawal? 

message: I question the validity of the statement "NMS should be ruled out in the case of acute behaviour change of any person on antipsychotic medication". Isn't the intended effect of antipsychotic medication to produce behavioural change, so a change in the behaviour of people starting treatment (the people most likely to be afflicted with NMS) shouldn't rule out anything — it should be expected. Neitherday (talk) 04:03, 17 December 2007 (UTC)
replies: text: I just read it again and what I meant was:
Acute and significant behaviour change/deterioration (eg: over a day or less) in someone who has otherwise been stable for a period of time on antipsychotics. (i.e. the dose hasn't been changed and the person hasn't deteriorated because of drug-taking or noncompliance)
I'll get a ref and figure out the best way to word it exactly. Is that clearer? cheers,  Casliber (talk · contribs) 04:38, 17 December 2007 (UTC)

text: I get it now, thank you. :) Neitherday (talk) 06:34, 17 December 2007 (UTC)
thread_title: Dubious

message: The rise in core temperature is really hyperthermia due mostly to excessive muscle activity and not fever, although these two are frequently mixed up (even the mesh definition for Neuroleptic malignant syndrome says 'fever').
Maybe this should be changed, although the useful mnemonic would also need to be altered.  —Preceding unsigned comment added by T vanhove (talk • contribs) 09:39, 30 December 2007 (UTC)
thread_title:  Fever vs Hyperthermia 

message: The article states, "Treatment is generally supportive." I have no idea what this means. Perhaps it is medical jargon. Perhaps it is a mistake. Either way, I think it could use some clarification. David (talk) 14:10, 24 March 2009 (UTC)
replies: text: It means that treatment targets whatever  symptoms the patient is having, instead of targeting the cause. Giving IV fluids, pain management, etc. Peetiemd (talk) 03:05, 13 May 2009 (UTC)

text: there you go, now there's a wikilink pointing at the section of "therapy" article (redirect from "supportive care") explaining what supportive care means.
176.63.176.112 (talk) 20:16, 28 February 2017 (UTC)

text: Thanks for the advice.  The page links to an article discussing how dantrolene sodium, bromocriptine, and apomorphine were studied, but the mechanism of how exactly they work still seems to be somewhat unknown.  jaykloo (talk) 5:12, 8 December 2009 (UTC)

text: Thanks for the ideas and the good paper. The paper is a bit older than some of our other sources, but I've included the bit you point out about the epidemiology.  Most of what that paper discusses about Epidemiology is discussed elsewhere in our article as well, so to avoid redundancy, we won't make many major changes to that section. jaykloo (talk) 5:12, 8 December 2009 (UTC)

text: Justindchien (talk) 01:45, 29 November 2009 (UTC)

text: Thank you for the advice, we have incorporated much of it! jaykloo (talk) 5:12, 8 December 2009 (UTC)

text: MichelleMaglio (talk) 18:35, 29 November 2009 (UTC)
thread_title:  "Supportive?" 

message: even with neuro pills, you cant stop nms that easily by stopping them, since your coming off neuro will take a significant amount of time even if you're on pills (much longer with injection, unless you're near the expiration of a lowest dose; besides, doctors are hard to make say ok to stopping neuro), and then it takes a long time for neuro to come out of the blood too.--78.156.109.166 (talk) 20:40, 17 December 2013 (UTC)
replies: text: Sorry, are you proposing a change in the article or simply making an observation? Decisions on continuing medication should be made individually, but should take into account the risk of recurrent NMS. JFW | T@lk 21:01, 17 December 2013 (UTC)
thread_title:  Stopping neuro to hinder nms? 

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thread_title:  External links modified 

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thread_title:  External links modified (February 2018) 

message: As per this article in Science, a major 2003 paper on neuroleptic malignant syndrome was by a researcher who was involved in massive amounts of fraud to the extent that he seems to have committed suicide upon being exposed. I'm concerned that this may affect the reliability of some of the papers cited in our article, but lack the skillset to make such an assessment. Anyone? DS (talk) 01:51, 22 August 2018 (UTC)
replies: text: Interesting - I presume you mean the Mihara paper (Sato is not mentioned as one of the authors...?)? I'll have a read a bit later today. Cas Liber (talk · contribs) 04:11, 22 August 2018 (UTC)
replies: text: Well, I don't know, is the thing. What if we cite scholarly article A, which cites scholarly article B, whose legitimacy is in question? DS (talk) 17:52, 22 August 2018 (UTC)
replies: text: Sigh. started looking...but really need to do a refresher on the whole topic....Cas Liber (talk · contribs) 00:43, 23 August 2018 (UTC)
thread_title:  Possible problem 

message: I think there is a numerical error in the 4th paragraph of the opening section.  "As of 2011, among those in psychiatric hospitals on neuroleptics about 15 per 100,000 are affected per year.[1] In the second half of the 20th century rates were higher at about 2% (2,000 per 100,000).[1]"  Should the figure 15 be 1.5? - unsigned contribution top-posted by  at 10:34, 29 January 2020. 
:  Believe it or not, no!  I've had another go at clarifying what the article is trying to convey here. - SquisherDa (talk) 13:15, 29 January 2020 (UTC)
thread_title: Fixed