Talk:T helper cell

message: The title image is misleading. The processing of becoming a CD4 or CD8 cell occurs in the thymus prior to puberty during development. A person logging on to this page will think that this process occurs normally. It does not. Once cells are in the periphery, they are either CD4 and CD8 and do not change (as far as I know). 
I chased up and looked at the reference. The image in the provided reference for the image has been substantially edited The arrows and most of the words have been added by whoever uploaded it. M0rt (talk) 05:53, 31 May 2009 (UTC)
thread_title:  Image is misleading and many pages have it 

message: I think we should still keep a seperate link to a more detailed TH1 and TH2 model page, due to the fact that the basic "type 1" and "type 2" concept is dated. For example, there are the proposed TH0 and TH3 sub-groups (although personally I'm weary of the proposals), but more importantly there is good evidence to suggest that during an in vivo response only a small percentage of T cells express cytokines of only one type (even if you exclude IL-2). The original model was based on hyperstimulated T cell lines, and therefore I see no reason not to highlight its limitations in a more technical page. The model was considered a breakthrough in how we see T cell responses, but there is MUCH more to the story than what is taught in third year university courses. I intend to write a seperate article on it at some point, but someone else is more than welcome to write it.
I think we also have to be very weary on a 20 year old "TH1 = macrophages, TH2 = B cells" mentality. That doesn't mean that it holds no merit, but it means that we have to be smart about how we write about this subject, because it is easy to over-simply the phenomenon. Volantares 09:49, 14 October 2005 (UTC)
thread_title:  T<sub>H</sub> model 

message: I don't think anyone reads this page, but I don't agree with the suggestion that Th1 cytokines produce auto-immune disease, while Th2 doesn't. It depends on the TYPE of auto-immunity: systemic lupus erythematosus has been associated with IL-4 (e.g. ref: Annals of the Rheumatic Diseases 2002;61:91-92) and I have some confidence that other antibody based autoimmunity is similar in mechanics. 59.167.10.179 13:42, 16 March 2006 (UTC)
replies: text: After years of evidence to the contrary (interferon-gamma-deficient animals develop more severe organ-specific autoimmune diseases, for instance), a substantial portion of research still believe Th1-polarized cells potentiate organ-specific autoimmune pathology. The new Th17 story seems to clarify some of that, but I'll easily grant that "Th1 = autoimmunity" thinking is probably at least as overly reductionist as the Th1/Th2 model itself. Jbarin 07:28, 8 May 2007 (UTC)
replies: text: This page gets about 1,000 page views a day. http://stats.grok.se/en/latest/T_helper_cell -- Nbauman (talk) 01:51, 11 November 2011 (UTC)
thread_title:  Any input? 

message: I don't know if there's anything on a count, but I did a quick scan for a number and found nothing. I know off the top of my head an average for a non-infected HIV/AIDS person is 500 to 1500 T cells for every cubic millimeter. And I searched something and found it drops roughly 50 to 100 each year with the virus. So maybe that can be added? Here's the link for reference. I dunno. It's on so many pages, varying only slightly between 400 and 500 or so, so it's definitely note-worthy. I'm just scared to put it in.-Babylon pride 18:22, 21 January 2007 (UTC)
replies: text: Just found out the count is mentioned on HIV Test but not here. Considering this is the main article and not just a random section, I'm just figuring...-Babylon pride 01:53, 22 January 2007 (UTC)
replies: text: Feel free to put it into the HIV section, although try and make it fit in with the rest of the section. If worst comes to worst, we'll just adjust it to read better. I do a lot of editing on this page and I try not to change things other people put in unless it's wrong, or it's already been said, or some other reason. Occassionally I may re-arrange things, but it's an open encyclopedia and everyone is working together to make it as good as possible. I think you should also ensure that there is a page which lists the immune cells present in different parts of the body, or at least blood, and their counts/percentages. I haven't seen one but I also haven't looked. I'm trying to finish a few things, then plan on referencing this article, before I go onto others.. my next aim may be to make the T helper/cytotoxic T cell/T cell articles consistent with each other in regards to locations of subjects, and consistency in things like activation, as the cytotoxic T cell version does not quite match what I was taught and have read. I'm sure there are people who are closer in research than I in that regard though.Volantares 12:10, 22 January 2007 (UTC)
thread_title:  Count 

message: lets merge them or eliminate one.
here they are...
http://en.wikipedia.org/wiki/Helper_T_cell   and
http://en.wikipedia.org/wiki/T_helper_cell
i think the first is more comprehensive, but the chart on the second is good.
Brendan19 06:16, 11 May 2007 (UTC)
replies: text: Doesn't one link to the other? Something strange is going on, though. I'd actually prefer the "parent" page as Helper_T_cell, and T_helper_cell linked to it, rather than it way it is now. Vote if you wish.121.44.39.68 16:41, 13 May 2007 (UTC)

text: Looks like no-one found the old Helper_T-cell article. Rod57 (talk) 14:06, 26 September 2010 (UTC)
thread_title:  we have two of the same page only slightly different 

message: It seems that TGF-beta is considered in the broader context as a Th2 cytokine along with IL-10 see  which is in conflict with the text of the Article. Can someone clarify for me, so that I can link to this site with some certainty? Jagra (talk) 03:59, 23 February 2008 (UTC)
replies: text: Thanks for the update and link to that excellent reveiw of PMID: 15280416. The IgG3 info is interesting given CFS has high TGF-b and low IgG 1 and 3 Also seems role in limiting autoimmunity of similar relevance, now only have to wait for trial! Can I suggest a new form of referencing for this page. Regards Jagra (talk) 04:33, 6 March 2008 (UTC)
thread_title: TGF-beta

message: Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 1989, 7:145-173
Clerici M, Shearer GM. A TH1-->TH2 switch is a critical step in the etiology of HIV infection. Immunology Today, 1993 14(3) :107-111.
Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunology Today, 1994 Dec; 15(2) :575-81.
Lucey DR, Clerici M et al. Type1 and Type2 cytokine dysregulation in human infections, neoplastic and inflammatory diseases. Clin Microbiol Rev 9 (4) 1996: 532-562.
Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Nat Acad Sci USA 1998; 95:3071-3076.
Murata, Y et al. The polarization of Th1/Th2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. International Immunology 2002, 14(2): 201-212.
Mosmann TR. Cytokine patterns during the progression to AIDS. Science, 1994 Jul 8;265(5169):193-4.
Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Alternative Medicine Review, Aug. 2003.  —Preceding unsigned comment added by 68.122.71.67 (talk) 21:43, August 27, 2007 (UTC) 
:The above are all great references, I would also include:
::Janeway, Charles A. Immunobiology : the immune system in health and disease. 6th ed.  New York : Garland Science, 2005.
:Why aren't any of these included in the article?--Jkuruppu (talk) 16:50, 12 May 2008 (UTC)
thread_title:  references 

message: Is there a particular reason CD40 and  CD154 or CD40L were not mentioned in the article? The latter, apart from other cells is expressed by activated T cells and is important in costimulation of B cells through direct cellular contact.
Moreover, the section heading is "Stimulation of Naive T cells"; is the activation of memory T cells fundamentally different? I don't have much idea of this topic, hence the query.
Hope my doubts are answered. Thanks in advance.
Regards.
—KetanPanchaltaLK 12:25, 28 May 2008 (UTC)
thread_title:  B cell costimulation 

message: I'm not sure the above is really correct. Certainly T helper cells are effector cells, but so are cytotoxic T cells. I think the AKA needs to be removed and reference made elsewhere that Th cells are amongst the effector (as opposed to memory) T cells. Thoughts? DoktorDec (talk) 02:51, 23 December 2008 (UTC)
thread_title:  "also known as effector T cells.." 

message: New subtype, generating IL22, named Th22 involved in psoriasis. Rod57 (talk) 13:58, 26 September 2010 (UTC)
thread_title:  TH22 

message: I checked out a few research papers and found NONE that has the h as subscript. Is there a reference to justify this? CielProfond (talk) 19:02, 27 November 2013 (UTC)
thread_title:  Subscript? 

message: Hey guys, "express" in the second paragraph, does it mean like "bind"? The text: Mature Th cells express the surface protein CD4 and are referred to as CD4+ T cells. CyberTroopers (talk) 11:30, 8 October 2020 (UTC)
replies: text: It means that the Th cells make the surface protein CD4. It does not mean "bind." CatPath meow at me 12:03, 8 October 2020 (UTC)
thread_title:  Express