Talk:Amphetamine

message: This article is a source for transcluded sections in Adderrall. Its a real house of cards -- reference definitions must be in certain spots, different sections are tagged with <noinclude and one article or another is often broken because of problems. Is transclusion really the best way to build these articles? -- Mikeblas (talk) 16:48, 31 May 2020 (UTC)
replies: text: Selective transclusion prevents information/content on multiple pages that cover the exact same topic from diverging over time. Yes, it does make it harder for unfamiliar editors to edit the source, at least initially when they're unfamiliar with the markup (see WP:SELTRANS for a primer). In this particular case, selective transclusions from amphetamine are used to ensure that this article, dextroamphetamine, lisdexamfetamine, and Adderall uniformly cover the same information in relevant sections. Seppi333 (Insert 2¢) 04:22, 17 November 2022 (UTC)
thread_title:  Transclusion 

message: 1. I just corrected the value for the fraction bound to 20%, according to the already linked source. Maybe they changed the value at some point. At the moment the source is DrugBank; section Protein binding: https://go.drugbank.com/drugs/DB00182#pharmacology. For said parameter the reference on DrugBank is solely this article: https://link.springer.com/article/10.2165/00003088-200443030-00002. Would it not be better if this source was mentioned in the article instead of Drugbank?
2. I also cross-checked said 20% with other publications and it's about right. So I guess there is no point in adding additional sources to prove the same number?
PENDRAGON (talk) 11:23, 13 October 2020 (UTC)
thread_title:  Reference to fraction bound by plasma proteins 

message: On of the image titles says "Pharmacodynamics of amphetamine in a dopamine neuron" there is no such thing as a dopamine neuron, it should be changed to dopaminergic neuron.  — Preceding unsigned comment added by Ihazevich (talk • contribs) 16:22, 17 February 2021 (UTC)
thread_title:  Dopamine neuron should be changed to dopaminergic neuron 

message: The Safety of Stimulant Medication Use in Cardiovascular and Arrhythmia Patients - American College of Cardiology
yo, stimulants are in fact cardio protective. has anyone given careful thought to this? The heart is a muscle. Muscles become stronger the more they work, The faster the heart beats the more oxygen is delivered. Blood circulates faster. these are good things. w/out preexisting heart conditions theres no issue… do marathon runners die prematurely? … i’ve taken these medications for decades - its only Vyvanese that has brought premature aging up - the 80 years before Vyvanese no one conclusively proved stimulants shorten people’s life spans. The truth is probnly that the way Vyvanese is metabolizedin the live by whatever enzynmee is it is in the liver that activates it causes long-term live damage and when your liver is gone - its over. Lastly speaking from personal experience Real Dexedrine or Adderall make my heart beat WAY faste than Vyvanese so that simple fact tells me this is to put it politely, highly questionable and to put it bluntly, bullshit . and if you drive a car on on overdrive but give extra attention to maintainihg it it will last long - its only if you aren’t healthy or dont maintauin your car in the first place that a issuew MAY come up. and people if you don’t know for god’s sake, if your skin doesn’t look good drink more water until you’re drinking 6liters a day. I bet crackheads who drink 6 liters of water a day have great skin! 72.143.21.46 (talk) 07:39, 24 December 2021 (UTC)
replies: text: Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Cannolis (talk) 07:43, 24 December 2021 (UTC)
thread_title:  Semi-protected edit request on 24 December 2021 

message: I am curious about what the policy is for including physicochemical data for pharmaceutical drugs.
The box in this page gives the data for amphetamine base racemate, yet this is not a form that is available on the market, legal or illegal.
There are of course many different salts and derivatives of the compound with different chemical structures and physical properties.
Is it standard to give the base form of amines? How about tertiary amines, which have no stable base form and potentially different counterions?
Would it make more sense to include all the common salts? Or perhaps have another page dedicated to it? Kilgore T (talk) 13:31, 26 October 2022 (UTC)
replies: text: In the US, there are at least two brand names of amphetamine, EVEKEO ODT is the racemic sulfate salt, while DYANAVELXR is a 3.2 to 1 mixture of d- to l-amphetamine and is a mixed salt.  I don't think it is practical to list all the avaiable salts, nor enantiomeric mixtures in the physicochemical properties section of the infobox, so I think it is appropiate to limit this section to the parent racemic free base.  Tertiary amines are stable compounds that can be isolated. It is the quaternary amine which when isolated, must be complexed with a counter ion. Amphetamine is a primary amine. I would not object if someone wanted to create a seperate data sheet for the racemic sulfate, etc. Boghog (talk) 07:41, 27 October 2022 (UTC)
thread_title:  Policy on chemical data 

message: Má huáng 1015 (talk) 22:25, 8 April 2023 (UTC)
replies: text: Not done for now: the image doesn't look line an improvement, though you're welcome to seek consensus for the alteration. M.Bitton (talk) 19:33, 9 April 2023 (UTC)
thread_title:  Semi-protected edit request on 8 April 2023 

message: Shouldn’t “amine”, located in the very first paragraph, be transformed into a link?
Is there a reason it hasn’t? HockeyCowboy (talk) 09:31, 28 April 2023 (UTC)
replies: text: I did. Hope that’s ok. HockeyCowboy (talk) 05:54, 30 April 2023 (UTC)
thread_title:  Amine 

message: I apologize for undoing what you wrote, but a lot of the content you introduced to the lead section is way too technical per MOS:INTRO. Also, the article originally had a 4-paragraph, 20-sentence lead section, which was already above average for a featured article, per MOS:LEADLENGTH. The lead looks to be about ~50% longer (24 vs 16 line breaks) on my screen with your changes relative to the original version, which pushes it well outside the guidelines.
I don't see a problem with introducing this content with citations in the body of the article, though. Seppi333 (Insert 2¢) 00:27, 22 July 2023 (UTC)
thread_title:  Lead content 

message: Why does this page list increased cognitive performance and increased muscle strength as effects? There have been no specifically conclusive, academically acceptable or even scientifically reasonable studies done to show that either of these effects occur in a significant enough portion of the general population to include them as "effects". There have, however, been studies to the contrary. 74.140.151.89 (talk) 20:43, 16 January 2024 (UTC)
thread_title:  Multiple Effect Citations Needed 

message: This section “ The oral bioavailability of amphetamine varies with gastrointestinal pH;[74] it is well absorbed from the gut, and bioavailability is typically 90%.[93] Amphetamine is a weak base with a pKa of 9.9;[94] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium.[94][74] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is absorbed.[94]” under the sub heading “Pharmacokinetics” is not relevant to Lisdexamphetamine. The pro drug is almost completely absorbed from the gastro system into the blood stream, and the majority of conversion from Lisdexamphetamine to Dextroamphetamine + Lysine happens in the blood stream. The pH is therefore not a factor in bioavailability for this drug. 
Please see here for evidence:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873712/
The section in Jimmymozzer (talk) 15:09, 6 June 2024 (UTC)
thread_title:  Semi-protected edit request on 6 June 2024