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Secondary outcomes: (1) Postoperative early pain (Visual Analog Score (VAS) at 6th and 24th hours of the surgery) (2) intraoperative complications, (3) postoperative complications conditions: Gynecologic Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHE... |
<|newrecord|> nctId: NCT06374927 id: PHRASE-2023 briefTitle: Personalised Health Cognitive Assistance for RehAbilitation SystEm (PHRASE): A Feasibility Study acronym: PHRASE-2023 overallStatus: RECRUITING date: 2024-04-25 date: 2024-10-01 date: 2024-10-30 date: 2024-04-19 date: 2024-04-23 name: Donders Centre for Neuro... |
The patient's journey to recovery in the healthcare system involves multiple phases, spanning from initial hospitalization to in-patient and out-patient rehabilitation, finally leading to the patient's return to home. The access to stroke units and rehabilitation varies within Europe. Unfortunately, not everyone has ac... |
Currently, the support of the patient is organized in a rather fragmented way, and informal care sometimes places a severe burden requiring dedicated support in the patient's social environment. The PHRASE project proposes to deploy rehabilitation technology such as the Rehabilitation Gaming System (RGS) to instil and ... |
There are many dedicated cognitive therapies, but most rehabilitation outcomes are mostly limited to the task trained and do not extend to day-to-day function or remain unconvincing. Based on recent literature, the PHRASE RGS-based system can provide an effective tool to address cognitive impairment using VR-based inte... |
The validation of the PHRASE system with post-stroke patients is needed to strengthen its usefulness and effectiveness for cognitive rehabilitation at home. For this, a feasibility study will be conducted to measure its usability, adherence, acceptance, and the user's experience. |
The investigators will also explore the effectiveness of the PHRASE system in improving cognitive function (attention, memory, executive function) after stroke. |
Participants: stroke patients at different time points after stroke (acute, subacute, and chronic), aged over 18 years. The participants will integrate the PHRASE technology into their daily routines in parallel to their regular neurorehabilitation treatment for 6 weeks. conditions: Stroke studyType: OBSERVATIONAL obse... |
<|newrecord|> nctId: NCT06374914 id: TUO-UR-23-05 briefTitle: Sequential Intravesical Gemcitabine and Docetaxel for Rescue Therapy in BCG Unresponsive Non-muscle Invasive Bladder Cancer Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-09 date: 2026-04-09 date: 2026-04-09 date: 2024-04-19 date: 2024-04-19 name: ... |
<|newrecord|> nctId: NCT06374901 id: IRB-2024-311 briefTitle: Tislelizumab Combined With Neoadjuvant Chemotherapy Used in the Perioperative Treatment. overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2026-03-31 date: 2028-03-31 date: 2024-04-19 date: 2024-04-19 name: Xiangdong Cheng class: OTHER name: Liaoning ... |
<|newrecord|> nctId: NCT06374888 id: CVL009-2002 briefTitle: Nilatinib Maleate Tablets Combined With Capecitabine in the Treatment of HER2-positive Advanced Esophageal/Esophagogastric Junction/Gastric Adenocarcinoma With Brain Metastases overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-09-30 date: 2027-07-... |
<|newrecord|> nctId: NCT06374875 id: 24-213 briefTitle: Fibrosis Lessens After Metabolic Surgery acronym: FLAMES overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2029-05-31 date: 2029-12-31 date: 2024-04-19 date: 2024-04-19 name: Ali Aminian class: OTHER briefSummary: Metabolic dysfunction-associated steatotic ... |
Patients meeting the inclusion and exclusion criteria and who give informed consent will be enrolled in the trial and undergo the baseline liver biopsy (if none available). Approximately 120 patients with MASH and liver fibrosis (F1-F4 in baseline liver biopsy) will be randomized in a 1:1 ratio to metabolic surgery or ... |
Pathologists who report the liver biopsies (to assess the primary end point of study) are blinded to treatment assignment whoMasked: OUTCOMES_ASSESSOR count: 120 type: ESTIMATED name: Metabolic surgery name: Incretin-Based Therapy measure: Improvement of at least 1 fibrosis stage of the Kleiner fibrosis classification ... |
<|newrecord|> nctId: NCT06374862 id: PI2024_843_0008 briefTitle: Effects of Specific Thoracic Spine Mobilizations on Muscle Activity in a Healthy Volunteer Population acronym: RACHI-MOB overallStatus: RECRUITING date: 2024-03-28 date: 2025-10 date: 2025-10 date: 2024-04-19 date: 2024-04-19 name: Centre Hospitalier Univ... |
<|newrecord|> nctId: NCT06374849 id: PI2023_843_0173 briefTitle: Intraoperative Sufentanil and Chronic Postsurgical Pain in Non-major Scheduled Abdominal Surgery acronym: ISPAIN overallStatus: RECRUITING date: 2024-03-17 date: 2026-04 date: 2026-07 date: 2024-04-19 date: 2024-04-19 name: Centre Hospitalier Universitair... |
In the field of CPSP, non-major abdominal surgeries remain poorly studied. This is due to their lower risk of CPSP than other surgeries such as orthopaedic, mammary or thoracic surgery. Nevertheless, they constitute a large number of daily surgical procedures. The estimated incidence of CPSP in non-major abdominal surg... |
<|newrecord|> nctId: NCT06374836 id: nWMO 2024.040 briefTitle: The Contractile Response of the Thoracic Aorta to Vasoactive Substances acronym: AorticContract overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-08 date: 2024-12 date: 2024-04-19 date: 2024-04-24 name: Catharina Ziekenhuis Eindhoven class: OTHER n... |
In the development of isolated systolic hypertension, the aorta plays a pivotal role. With each heartbeat, the heart empties its stroke volume into the large arteries. These arteries, particularly the thoracic part of the aorta, temporarily distend to buffer the stroke volume and thereby dampen the pressure fluctuation... |
Likely, the aorta is not just a passive structure (the aorta as an elastic 'bicycle tube'). Rather, the smooth muscle cells in the aorta wall can presumably actively change the aorta's dimension through vasoconstriction/-dilation. If this is the case, such vasoconstriction/-dilation will have direct consequences for th... |
During the study we will measure in the operating room the thoracic descending and ascending aortic diameter with transoesopahgeal echocardiography (part of standard clinical care), before and after administration of vasoactive drugs (phenylephrine and norepinephrine; also part of standard clinical care). During these ... |
<|newrecord|> nctId: NCT06374823 id: IIT2023-020-002 briefTitle: Multiple Electrolytes Injection (II) and Normal Saline on Hyperchloremia in Severe Hemorrhagic Stroke acronym: MERIT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2026-12 date: 2024-04-19 date: 2024-04-19 name: Capital Medical Univer... |
<|newrecord|> nctId: NCT06374810 id: CCB1 briefTitle: Does Conscious Connected Breathwork Reduce Symptoms of Anxiety? overallStatus: COMPLETED date: 2023-09-21 date: 2023-12-20 date: 2023-12-20 date: 2024-04-19 date: 2024-04-22 name: Richard Blake class: OTHER briefSummary: The goal of this clinical trial is to test wh... |
The main questions aims to answer: |
1. Does conscious connected breathwork reduce symptoms of anxiety? |
2. Does an increased frequency of self-practice lead to even greater reductions of anxiety symptoms. |
there is a comparison group: Researchers will compare whether people doing the breathwork to see if \[insert effects\]. |
Participants will participate in 1, 90 minute breath workshop per week for 6 weeks. These sessions will be held on Zoom by 2 facilitators. Participants will also be given a 10 minute recording of a guided conscious connected breathwork session that they will be encouraged to complete daily. conditions: Anxiety studyTyp... |
Participants in the breathwork groups were also given a 10 minute guided conscious connected breathwork recording. They were advised to do this daily to support the integration of their process. This was not mandatory. At the end of the study participants were asked how often they used the guided self-practice. The fre... |
<|newrecord|> nctId: NCT06374797 id: CMZ-207 briefTitle: A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk" acronym: KOURAGE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-08 date: 2025-08 date: 2024-04-19 date: 2024-04-19 name: CalciMedica, Inc. class: INDUSTRY briefSummary: Approximatel... |
<|newrecord|> nctId: NCT06374784 id: perio2023ARP briefTitle: Autogenous Demineralized Dentin Graft Combined With Injectable PRF + Metronidazole Versus Autogenous Demineralized Dentin Graft Combined With Injectable PRF Versus Autogenous Demineralized Dentin Graft Alone for Alveolar Ridge Preservation overallStatus: NOT... |
<|newrecord|> nctId: NCT06374771 id: MD-15-2022 briefTitle: Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery. overallStatus: NOT_YET_RECRUITING date: 2024-04-27 date: 2024-06-27 date: 2024-07-10 date: 2024-04-19 date: 2024-04-19 name: Cairo University class:... |
This study hypothesizes that using both vitamin C and melatonin together as adjuvants will cause: |
* More reduction in total morphine consumption in the first 24 hours postoperatively |
* More reduction of the incidence of chronic post-surgical pain, than using each adjuvant alone. |
Participants will be allocated into three equal groups: Melatonin (M group) and vitamin C (V group), and Melatonin and vitamin C (VM group). Two hours before surgery all patients will receive the study drugs orally and will be continued for 3 days postoperative at the same time of the first administration; 10mg of mela... |
Researchers will compare: |
* The effect of melatonin, vitamin C, and their combination on postoperative opioid consumption |
* The severity of postoperative pain, using the Numerical Rating Scale (NRS) |
* Patients' satisfaction with a three-point scale |
* The time of the first requirement for rescue analgesia |
* The effect on the incidence of chronic post-surgical pain. conditions: Postoperative Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_AS... |
<|newrecord|> nctId: NCT06374758 id: MU-2096449 briefTitle: Accelerated ART Initiation for PWHIV Who Are Out of Care acronym: ACCELERATE overallStatus: RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-11-01 date: 2024-04-19 date: 2024-04-19 name: University of Missouri-Columbia class: OTHER name: Gilead Sciences... |
<|newrecord|> nctId: NCT06374745 id: 2020-01307; mu24Kappos briefTitle: An Integrated Algorithm for Surgical Intervention in Chronic Lymphedema After Breast Cancer Treatment: The Basel Lymphedema Protocol overallStatus: RECRUITING date: 2015-01-02 date: 2024-12-30 date: 2024-12-30 date: 2024-04-19 date: 2024-04-19 name... |
<|newrecord|> nctId: NCT06374732 id: TY2024002 briefTitle: The Benefits of a High-intensity Interval Training Intervention Delivered in a School Setting Among Adolescents overallStatus: RECRUITING date: 2024-02-26 date: 2024-10-01 date: 2024-10-01 date: 2024-04-19 date: 2024-04-19 name: University of Exeter class: OTHE... |
<|newrecord|> nctId: NCT06374719 id: WiTNNess briefTitle: WiTNNess - TNNT1 Myopathy Natural History Study acronym: WiTNNess overallStatus: RECRUITING date: 2018-09-23 date: 2027-01-01 date: 2027-06-01 date: 2024-04-19 date: 2024-04-19 name: Clinic for Special Children class: OTHER briefSummary: WiTNNess is designed to ... |
<|newrecord|> nctId: NCT06374706 id: 23-0129 briefTitle: Effects of End-Effector Type Rehabilitation Robots-Morning Walk on Symmetrical Walking Patterns in Individuals With Hemiparesis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-01 date: 2025-08-30 date: 2024-04-19 date: 2024-04-19 name: The Univer... |
<|newrecord|> nctId: NCT06374693 id: STH22772 briefTitle: Investigating the Tolerability and Feasibility of Transcutaneous Vagus Nerve Stimulation Following Aneurysmal Subarachnoid Haemorrhage acronym: tVNS in aSAH overallStatus: NOT_YET_RECRUITING date: 2024-04-14 date: 2025-08 date: 2025-08 date: 2024-04-19 date: 202... |
Transcutaneous vagus nerve stimulation (tVNS) is a technique where a small handheld device is attached to an earpiece which stimulates the nerves to the ear. This is given for short periods and may help improve blood flow and reduce inflammation in the brain. The intervention has been safely used and licensed in seizur... |
This study will look to see if it is feasible and tolerable to have tVNS twice daily for 5 days after subarachnoid haemorrhage, and whether it can help reduce the risk of complications from subarachnoid haemorrhage. |
The participant will be randomly allocated to receive either tVNS or a dummy intervention, known as sham. |
The researchers will collect some personal and clinical details such as diagnosis, medications, age, blood test results, as well as some details about the subarachnoid haemorrhage. |
The researchers will also complete brief questionnaires with the participant to assess symptoms. They will take measurements of heart rate, pupil response, and brain activity using a cap. The participant will then be randomly allocated to either receive the tVNS or sham intervention. |
Next, the research team will apply the earpiece to their ear twice a day for 45 minutes, for a total of 5 days. |
At the end of the 5-day study period, the intervention will be complete. The researchers will arrange a follow-up meeting on discharge and at 6 weeks, to assess the participants symptoms and recovery. |
Previous studies have shown that tVNS is safe and well tolerated, including a recent review of tVNS studies which evaluated the side effects experienced by 1322 patients receiving tVNS. |
The main side effects include localised tingling/numbness/pain/redness around the ear (17%), headaches (3%), dizziness (1%), facial droop (1%), nausea (1%), nasal discharge (2%). Rarely, palpitations or a slow heart rate may occur. |
They will continue to receive full medical treatment and observation alongside the study. They are free to withdraw from this study if they find it too demanding on top of their other activities. conditions: Subarachnoid Haemorrhage From Cerebral Aneurism Rupture studyType: INTERVENTIONAL phases: NA allocation: RANDOMI... |
<|newrecord|> nctId: NCT06374680 id: C3 ectomy briefTitle: C3 Laminectomy With Cervical Laminoplasty overallStatus: WITHDRAWN date: 2017-03-20 date: 2021-12-31 date: 2021-12-31 date: 2024-04-19 date: 2024-04-22 name: Seoul National University Hospital class: OTHER briefSummary: 1. Background In cervical stenosis, cervi... |
2. Purpose The aim of this study was to compare the prospective randomized comparison of these two surgical methods. |
3. Hypothesis There is no difference in the cervical length and overall cervical angle between 1 month, 3 months, 6 months, and 12 months postoperatively between C3 laminectomy with C4-6 laminoplasty and C3-6 laminoplasty. conditions: Neck Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPE... |
<|newrecord|> nctId: NCT06374667 id: KY2024-071-02 briefTitle: The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction acronym: SOLUTION-2 overallStatus: RECRUITING date: 2024-04-22 date: 2025-09-15 date: 2026-03-15 date: 2024-04-1... |
<|newrecord|> nctId: NCT06374654 id: 2023P003272 briefTitle: RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-04-18 date: 2024-04-18 name: Brigham and Women's Hospital clas... |
<|newrecord|> nctId: NCT06374641 id: 5514255 briefTitle: The Effects of a Novel Mitochondrial Substrate Supplement on Exercise Performance and Cognitive Function acronym: MCh1 overallStatus: RECRUITING date: 2024-03-26 date: 2025-04 date: 2025-08 date: 2024-04-18 date: 2024-04-18 name: University of Exeter class: OTHER... |
The main questions it aims to answer are: |
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