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<|newrecord|> nctId: NCT06375837 id: bioactive-NCCLs briefTitle: Comparative Evaluation of an Alkasite-based Restorative Material and Two Different Resin Composites overallStatus: RECRUITING date: 2024-04-15 date: 2024-06-15 date: 2026-06-15 date: 2024-04-19 date: 2024-04-19 name: Hacettepe University class: OTHER brie... |
<|newrecord|> nctId: NCT06375824 id: TCM for Pre-COPD briefTitle: Bufei Recipe Reduces the Incidence Rate of COPD overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-04-30 date: 2027-10-31 date: 2024-04-19 date: 2024-04-19 name: Henan University of Traditional Chinese Medicine class: OTHER name: West China Ho... |
<|newrecord|> nctId: NCT06375811 id: 2000027121_temp briefTitle: Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp acronym: PREGnant overallStatus: RECRUITING date: 2024-03-16 date: 2026-06-30 date: 2026-06-30 date: 2024-04-19 date: 2024-04-23 name: Yale University class: OTHER name: University ... |
<|newrecord|> nctId: NCT06375798 id: 2020137 briefTitle: Clinical Study of Breast Conserving Surgery Combined With Intraoperative Radiotherapy for Early Breast Cancer overallStatus: RECRUITING date: 2020-11-19 date: 2026-11-19 date: 2026-11-19 date: 2024-04-19 date: 2024-04-19 name: Hebei Medical University Fourth Hosp... |
<|newrecord|> nctId: NCT06375785 id: LSVT-BIG vs Otago briefTitle: Two Different Exercise Methods in Geriatrics overallStatus: COMPLETED date: 2023-03-01 date: 2023-06-01 date: 2024-03-01 date: 2024-04-19 date: 2024-04-23 name: Halic University class: OTHER name: Fenerbahce University name: Istanbul Galata University n... |
<|newrecord|> nctId: NCT06375772 id: 2-DG-02 briefTitle: A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults overallStatus: RECRUITING date: 2024-04-02 date: 2024-08-31 date: 2024-12-31 date: 2024-04-19 date: 2024-04-19 name: G.ST Antivirals GmbH class: INDUSTRY briefSummary: 2-DG-02 is... |
<|newrecord|> nctId: NCT06375759 id: XWSSB briefTitle: Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia overallStatus: RECRUITING date: 2024-04 date: 2025-04 date: 2027-04 date: 2024-04-19 date: 2024-04-19 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: To... |
<|newrecord|> nctId: NCT06375746 id: 0091-22-WOMC briefTitle: The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve - a Randomized Controlled Trial overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-08-01 date: 2024-08-31 date: 2024-04-19 date: 2024-04-19 name: Wolfson M... |
<|newrecord|> nctId: NCT06375733 id: GFH009X1202 briefTitle: A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL overallStatus: RECRUITING date: 2024-03-20 date: 2026-12-31 date: 2026-12-31 date: 2024-04-19 date: 2024-04-19 name: Zhejiang Genfleet Therapeutics Co., Ltd. clas... |
<|newrecord|> nctId: NCT06375720 id: FujianUTCM-2 briefTitle: Efficacy of Different Doses of Tai Chi Chuan on Cognitive Function in Persons With Mild Cognitive Impairment overallStatus: NOT_YET_RECRUITING date: 2024-05-05 date: 2025-06-15 date: 2025-12-15 date: 2024-04-19 date: 2024-04-19 name: Lidian Chen class: OTHER... |
<|newrecord|> nctId: NCT06375707 id: HERO-KC23 briefTitle: Efficacy and Safety of Ribociclib in Combination With NSAI Versus Physician's Choice of Chemotherapy Sequential Endocrine Therapy in HR+/HER2- Advanced Breast Cancer overallStatus: RECRUITING date: 2024-01-09 date: 2025-11 date: 2025-12 date: 2024-04-19 date: 2... |
<|newrecord|> nctId: NCT06375694 id: IRB00025485 briefTitle: Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN ) acronym: OPEDNPN overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-05 date: 2025-05 date: 2024-04-19 date: 2024-04-19 name: Wake Forest University class: OTHER name: Univers... |
In addition to being made naturally in the body, NO can be obtained through the diet via the Nitrate-Nitrite-NO cycle. Nitrate, which is abundant in green leafy vegetables and beetroot juice, is partially converted to nitrite by oral bacteria. The nitrate and nitrite are taken up into the blood and nitrite is converted... |
The current study rests on the premise that the quality of the oral microbiome plays a major role in the Nitrate-Nitrite-NO cycle and hence cardiovascular health and the efficacy of dietary nitrate interventions. Investigators have begun to identify oral bacterial species that are effective nitrite producers as well as... |
In laboratory experiments, certain bacterial species have been shown to block nitrate to nitrite conversion by other oral bacteria. These nitrite depleting species are found in a commercially available oral probiotic designed to improve oral health. The purpose of this study is to examine if use of the probiotic negati... |
While this study does not aim to treat any specific disease, it is intended to elucidate a basic physiological function that may be relevant to cardiovascular health and certain NO-based therapeutics. conditions: Hypertension conditions: Cardiovascular Diseases conditions: Diabetes studyType: INTERVENTIONAL phases: NA ... |
<|newrecord|> nctId: NCT06375681 id: 2019-1378: R01 id: 1R01AG076157-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01AG076157-01 id: A487400 type: OTHER domain: UW Madison briefTitle: Effectiveness of Cognitive Training in Older and Younger Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 202... |
The full description of the study's 9 arms will be registered after data collection is completed to preserve the scientific integrity of the study. primaryPurpose: BASIC_SCIENCE masking: DOUBLE maskingDescription: All researchers that have contact with participants will be unaware of the tested hypothesis of the study. |
Participants will be unaware of the experimental conditions. |
Researchers and participants will be unaware (blinded) to the game conditions assigned to the participant, except for researchers in charge of supervising the training part of the study who will be aware what training the participant is undergoing. |
More information on how this was achieved will be registered after data collection is completed to preserve the scientific integrity of the study. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 1600 type: ESTIMATED name: Visual and / or Auditory Cognitive Tasks (1) name: Visual and / or Auditory Cognitive T... |
<|newrecord|> nctId: NCT06375668 id: CT/NB/140/2020/PR-MS briefTitle: The Effect of the Probiotic Strains on Bone Mineral Density in Postmenopausal Women overallStatus: ACTIVE_NOT_RECRUITING date: 2022-03-15 date: 2024-01-15 date: 2024-06-15 date: 2024-04-19 date: 2024-04-24 name: Nordic Biotic Sp. z o.o. class: INDUST... |
<|newrecord|> nctId: NCT06375655 id: STUDY20240085 briefTitle: Texting to Promote Breastfeeding (TOPS) overallStatus: NOT_YET_RECRUITING date: 2024-07-31 date: 2025-07-31 date: 2025-07-31 date: 2024-04-19 date: 2024-04-24 name: Lydia Furman class: OTHER briefSummary: The purpose of the study is to see if a program of t... |
<|newrecord|> nctId: NCT06375642 id: SHR1316-HMPL012-HAIC-01 briefTitle: A Single Arm, Single Centered Phase II Trial on the Combination of Adebrelimab, Surufatinib and Irinotecan Liposome-based HAIC in Advanced iCC overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2025-08-31 date: 2026-08-31 date: 2024-04-19 da... |
Hepatic arterial infusion chemotherapy (HAIC) has gradually emerged as a promising treatment option for patients with hepatocellular carcinoma (HCC). Increasing evidence suggests that infusion of HAIC, which maintains high local concentrations of toxic agents in tumors without embolism, provides a significant survival ... |
Irinotecan liposome (nal-IRI) is a concentrate of an infusion solution containing 5 mg/ml irinotecan trihydrate (irinotecan sucrose salt) active substance, which is encapsulated in liposomes and prevents premature conversion of the drug to SN-38 in the liver. Liposomal irinotecan prolongs the circulation time of the dr... |
Adebrelima(SHR-1316) is a recombinant humanized IgG4 antibody that binds efficiently and specifically to human and cynomolgus programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), a cell surface molecule that plays an important role in T cell immune function, and stimulates IFN-γ secretion from mixed lymphocyte reac... |
Surufatinib is a multiple kinase inhibitor targeting VEGFR 1-3, FGFR1 and CSF1R. |
This study aims to evaluate the efficacy and safety of irinotecan liposome-based hepatic arterial infusion chemotherapy combined with adebrelimab and surufatinib in the treatment of intrahepatic cholangiocarcinoma, which may bring significant clinical benefit to the iCC patients with new treatment options. conditions: ... |
<|newrecord|> nctId: NCT06375629 id: EDAP TMS briefTitle: ES-HIFU, Prospective Data Collection of Patients Treated With Partial Gland HIFU Ablation for Prostate Cancer acronym: ES-HIFU overallStatus: RECRUITING date: 2023-04-20 date: 2027-04-20 date: 2027-04-20 date: 2024-04-19 date: 2024-04-19 name: EDAP TMS S.A. clas... |
<|newrecord|> nctId: NCT06375616 id: KY2024-023 briefTitle: Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-04 date: 2024-04-19 date: 2024-04-19 name: Shen Lei class: OTHER briefSummary: The goal of this clinic... |
The impact of NM and UFH on platelet count in septic patients undergoing RRT treatment. |
The satisfaction with anticoagulation of NM and UFH in septic patients undergoing RRT treatment. |
The 28-day all-cause mortality rate of septic patients undergoing RRT treatment with NM and UFH. |
Researchers will use NM or UFH as anticoagulation during RRT in SA-AKI patients, assessing effects on platelet count, anticoagulation satisfaction, and mortality. |
Participants will receive NM or UFH as anticoagulation during RRT for a minimum of 7 days. Bleeding symptoms, platelet count and coagulation function will be monitored daily. Platelet changes during the 7-day treatment period and survival status at 28 days post-treatment will be recorded. conditions: Sepsis studyType: ... |
<|newrecord|> nctId: NCT06375603 id: SMARTALPHA-NERVEBLOX-1001 briefTitle: Nerve and Plane Block Data Collection Study for the Development of Artificial Intelligence-assisted Software overallStatus: COMPLETED date: 2022-12-01 date: 2023-05-01 date: 2023-05-01 date: 2024-04-19 date: 2024-04-19 name: Smart Alfa Teknoloji... |
<|newrecord|> nctId: NCT06375590 id: 2024-NavIIcusp briefTitle: NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2026-05-01 date: 2024-04-19 date: 2024-04-19 name: Didier TCHETCHE class: OTHER name: Abbott ... |
<|newrecord|> nctId: NCT06375577 id: LMS-24-Dean-1 briefTitle: Speed of Absorption overallStatus: RECRUITING date: 2024-06 date: 2025-04 date: 2025-04 date: 2024-04-19 date: 2024-04-22 name: Lancaster University class: OTHER briefSummary: The purpose of this study is to look at how fast commercially available supplemen... |
Each visit will take approximately 1 hour and 30 minutes, and three experimental visits per participant. The study will involve frequent blood sampling and the continuous monitoring of gas exchange (oxygen/carbon dioxide). Blood sampling via cannulation will be used to analyse the lactate, glucose, and insulin content ... |
The investigators plan to carry out the study on 16 participants who will be a mix of male runners, cyclists and triathletes. conditions: Healthy conditions: Nutrition, Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This will be a double-bl... |
Condition 1 - consume Voom Pocket Rocket. Condition 2 - consume SIS Isotonic Energy Gel. Condition 3 - consume Maurten Gel 160. |
All participants will undergo the same measures - blood sampling for blood glucose, blood lactate, and insulin, and monitoring of gas exchange during each study visit. primaryPurpose: BASIC_SCIENCE masking: DOUBLE maskingDescription: Both the participants and investigators will be blinded to what supplement they are co... |
<|newrecord|> nctId: NCT06375564 id: XMYY-2020KY067-05 briefTitle: Clinical Evaluation of 177Lu-AB-3PRGD2 in Various Solid Tumors With Integrin αvβ3 Positive Expression overallStatus: RECRUITING date: 2024-05-01 date: 2025-12-30 date: 2026-12-30 date: 2024-04-19 date: 2024-04-23 name: The First Affiliated Hospital of X... |
<|newrecord|> nctId: NCT06375551 id: 1171-0623 id: K01MH128761 type: NIH link: https://reporter.nih.gov/quickSearch/K01MH128761 briefTitle: K-ORCA: Testing a Decision Support Tool and Group Process for Selecting Interventions acronym: K-ORCA overallStatus: NOT_YET_RECRUITING date: 2024-07-31 date: 2027-07-31 date: 2027... |
<|newrecord|> nctId: NCT06375538 id: B2022-527 briefTitle: Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy overallStatus: RECRUITING date: 2022-10-21 date: 2025-08-31 date: 2025-12-31 date: 2024-04-19 date: 2024-04-19 name: Shanghai Zhongshan Hospital... |
<|newrecord|> nctId: NCT06375525 id: SHEBA-15-2635-SMC briefTitle: Clinical Trial: The Efficacy of Janssen's Icon Application (App) in Improving Adherence to Treatment With Stimulant Medications in Children With Attention Deficit/Hyperactivity Disorder acronym: App ADHD overallStatus: COMPLETED date: 2015-11 date: 2017... |
Our specific hypotheses are: |
1. In children receiving medication for ADHD those provided with the App tool will be more adherent to treatment than children treated as usual (i.e., not provided with the App tool). |
2. Adherent patients will show greater improvement of ADHD symptoms and related dysfunction. conditions: Children Aged 6-18 Years With the Diagnosis of ADHD studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 39 type: ACTUAL name: Janssen's ... |
<|newrecord|> nctId: NCT06375512 id: IN001001 briefTitle: A Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-12 date: 2026-06 date: 2024-04-19 date: 2024-04-19 name: Shenzhen Sh... |
<|newrecord|> nctId: NCT06375499 id: LT2769-004 briefTitle: Comparison of the Performance and Safety of T2769 Versus Hylo-Forte® in the Treatment of Moderate to Severe Dry Eye Syndrome. overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-04-28 date: 2025-04-28 date: 2024-04-19 date: 2024-04-19 name: Laboratoi... |
The investigation is defined as a post-market stage. The clinical investigation design is confirmatory. conditions: Dry Eye Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: INVESTIGATOR count: 74 type: ESTIMATED name: T... |
<|newrecord|> nctId: NCT06375486 id: AK112-IIT-TianjinCIH-LHK briefTitle: Ivonescimab Combined With HAIC for the Treatment of Unresectable Hepatocellular Carcinoma（uHCC）. overallStatus: RECRUITING date: 2024-03-14 date: 2025-03-14 date: 2026-06-15 date: 2024-04-19 date: 2024-04-19 name: Tianjin Medical University Cance... |
All enrolled subjects will receive AK112 (20mg/kg Q3W) combined with HAIC (utilizing the FOLFOX chemotherapy regimen) until the investigator determines no further clinical benefit (based on RECIST v1.1 imaging evaluation and clinical assessment), intolerable toxicity, completion of 24 months of treatment, or meeting ot... |
<|newrecord|> nctId: NCT06375473 id: MA-PC-RWS-011 briefTitle: Treatment of Irinotecan Hydrochloride Liposome Injection II in China: a Real World Study of Pancreatic Cancer Patients acronym: MA-PC-RWS-011 overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2027-04-19 date: 2027-04-19 date: 2024-04-19 date: 2024-04... |
<|newrecord|> nctId: NCT06375460 id: STUDY24020141 id: 1R01DK137803-01A1 type: OTHER_GRANT domain: NIDDK briefTitle: Real-time Engagement for Learning to Effectively Control Type 2 Diabetes acronym: REFLECT2D overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2028-06-01 date: 2029-06-30 date: 2024-04-19 date: 202... |
<|newrecord|> nctId: NCT06375447 id: Insomnia briefTitle: Intelligent Diagnosis and Treatment Model for Insomnia Disorder overallStatus: RECRUITING date: 2022-12-01 date: 2025-10-31 date: 2025-12-31 date: 2024-04-19 date: 2024-04-19 name: Xuanwu Hospital, Beijing class: OTHER name: West China Hospital name: Beijing Tia... |
<|newrecord|> nctId: NCT06375434 id: 20240101-01 briefTitle: Correlation Between Gut Microbiota and Radiosensitivity of Rectal Cancer acronym: GMRSC-LARC overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-08-15 date: 2024-08-31 date: 2024-04-19 date: 2024-04-19 name: Jing-kun Liu class: OTHER briefSummary: T... |
<|newrecord|> nctId: NCT06375421 id: GR018280 briefTitle: Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury overallStatus: ENROLLING_BY_INVITATION date: 2024-04-03 date: 2024-12-31 date: 2024-12-31 date: 2024-04-19 date: 2024-04-19 name: Vanderbilt University Medical Center class: OTHER briefSummary: Thi... |
<|newrecord|> nctId: NCT06375408 id: KS2022212 briefTitle: Transcranial Alternating Current Stimulation Prevents Delirium in Patients With Subarachnoid Hemorrhage acronym: TACS overallStatus: RECRUITING date: 2024-03-24 date: 2026-02-24 date: 2026-03-24 date: 2024-04-19 date: 2024-04-19 name: Xuanwu Hospital, Beijing c... |
• To evaluate the effect of tACS on reducing delirium in patients with subarachnoid hemorrhage. |
Participants will treated with real tACS or sham tACS. Researchers will mainly compare the two groups to see if patients' delirium will reduce by using tACS. conditions: Subarachnoid Hemorrhage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QU... |
<|newrecord|> nctId: NCT06375395 id: Memory Updating Tasks briefTitle: Boosting The Intervention Effect of Negative Memory Through tACS Stimulation overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-12-15 date: 2024-12-31 date: 2024-04-19 date: 2024-04-19 name: Xuanwu Hospital, Beijing class: OTHER name: Bei... |
<|newrecord|> nctId: NCT06375382 id: ZYS2024-01 briefTitle: Effects of Acupuncture on Abdominal Pain-related Intestinal Flora in Patients With Crohn's Disease overallStatus: COMPLETED date: 2015-03-01 date: 2023-12-31 date: 2024-03-31 date: 2024-04-19 date: 2024-04-19 name: Shanghai Institute of Acupuncture, Moxibustio... |
<|newrecord|> nctId: NCT06375369 id: Pro00127121 briefTitle: Digital Health Pathway for Children With Medical Complexity Requiring Tracheostomy acronym: DECIDE-T overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-19 date: 2024-04-23 name: University of Alberta class: OTHE... |
The goal of the DECIDE-T project is to reduce hospital stays and associated costs for children requiring tracheostomy/LTV, as well as to decrease mental distress and burnout experienced by their caregivers and families. conditions: Tracheostomy studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventio... |
<|newrecord|> nctId: NCT06375356 id: 75119 briefTitle: Stronger: Muscle Strengthening for Menopause overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2026-08 date: 2026-08 date: 2024-04-19 date: 2024-04-19 name: Stanford University class: OTHER briefSummary: Menopause is a period of time with increased risk for mus... |
<|newrecord|> nctId: NCT06375343 id: SOPH240-0923/I briefTitle: Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive® overallStatus: NOT_YET_RECRUITING date: 2024-10-30 date: 2024-10-30 date: 2025-06 date: 2024-04-19 date: 2024-04-19 name: Laboratorios Sophia S.A de C.V. class: INDUSTRY briefSummary: This... |
<|newrecord|> nctId: NCT06375330 id: Poli.01 briefTitle: Clinical Efficacy of Polynucleotides TMJ Injections Compared to Physiotherapy. overallStatus: COMPLETED date: 2023-04-18 date: 2024-01-08 date: 2024-04-08 date: 2024-04-19 date: 2024-04-19 name: Sidoti & Tartaglia Srl class: OTHER briefSummary: The main objective... |
<|newrecord|> nctId: NCT06375317 id: HCC-HAIC-001 briefTitle: HAIC Combined With PD-L1 Plus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma After Immunotherapy Failure overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-04-30 date: 2026-10-30 date: 2024-04-19 date: 2024-04-19 name: Yehua She... |
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