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This study will retrospectively and prospectively collect real-world data related to investigational drugs, and will observe 500 patients to observe the diagnosis and treatment pattern of radiochemo-induced thrombocytopenia. The study included a screening period (no more than one week) and a treatment period (at least ... |
<|newrecord|> nctId: NCT06376422 id: EU-CT-2023-508271-36-00 briefTitle: Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss overallStatus: RECRUITING date: 2024-05-01 date: 2029-04-30 date: 2031-04-30 date: 2024-04-19 date: 2024-04-19 name: Privatpraxis für Knie- un... |
* Can partial meniscal replacement improve knee function? |
* Can partial meniscal replacement prevent/postpone total meniscal replacement/knee prothesis? Researchers will compare the results of the operated group with patients not willing to be operated but with partial meniscal loss to see if the operation improves knee function. |
Participants will be operated and have to attend follow-up visits with MRI after 6 months up to 5 years after surgery. conditions: Meniscus Lesion studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE maskingDescription: no masking, patient d... |
<|newrecord|> nctId: NCT06376409 id: NW-HGN-02 briefTitle: Prospective Study of Nutraceutical Supplements to Support Hair Growth in Females overallStatus: NOT_YET_RECRUITING date: 2024-05-06 date: 2025-04-01 date: 2025-06-01 date: 2024-04-19 date: 2024-04-23 name: Nutraceutical Wellness Inc. class: INDUSTRY briefSummar... |
<|newrecord|> nctId: NCT06376396 id: 101103306 briefTitle: Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis acronym: NeuroSolve overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-12 date: 2024-04-19 date: 2024-04-23 name: R-Evo... |
<|newrecord|> nctId: NCT06376383 id: TETT-RHG id: 110500 type: OTHER domain: The Central Denmark Region Committees on Health Research Ethics briefTitle: Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2026-12 date: 2027-09 date: 2024-04-19 date... |
<|newrecord|> nctId: NCT06376370 id: 16.04.24/2 briefTitle: The Effect of a Computer-Assisted Rehabilitation Program on Epilepsy Patient overallStatus: ENROLLING_BY_INVITATION date: 2024-04-26 date: 2024-06-10 date: 2024-07-28 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSummary: The aim ... |
<|newrecord|> nctId: NCT06376357 id: 16.04.24/1 briefTitle: The Effect of Foot Massage With Roles on Cancer Patients overallStatus: ENROLLING_BY_INVITATION date: 2024-04-27 date: 2024-06-15 date: 2024-07-30 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSummary: It was aimed to examine the ... |
<|newrecord|> nctId: NCT06376344 id: 16.04.24 briefTitle: The Effect of Tennis Ball on Balance and Quality of Life in Cancer Patients With Neuropathy. overallStatus: ENROLLING_BY_INVITATION date: 2024-04-28 date: 2024-06-10 date: 2024-07-10 date: 2024-04-19 date: 2024-04-19 name: Selcuk University class: OTHER briefSum... |
<|newrecord|> nctId: NCT06376331 id: ADHD20240403 briefTitle: Washed Microbiota Transplantation for Attention-deficit/Hyperactivity Disorder overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2027-06-01 date: 2027-07-01 date: 2024-04-19 date: 2024-04-24 name: The Second Hospital of Nanjing Medical University clas... |
<|newrecord|> nctId: NCT06376318 id: 19-138 briefTitle: Shock and Acute Conditions OutcOmes Platform acronym: ShockCO-OP overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2025-07-01 date: 2026-01-01 date: 2024-04-19 date: 2024-04-19 name: Saint-Louis Hospital, Paris, France class: OTHER name: University of He... |
Currently, there are no markers that allow us to classify patients with circulatory shock at higher risk of early and late bad outcomes, or who may better respond to a specific intervention. |
To understand the contribution of biological heterogeneity to circulatory shock independently from its etiology, the ShockCO-OP Research Program aims to use clustering approaches to re-analyze existing clinical and molecular data from several large European and North American prospective cohorts and clinical trials. |
This will enable an improvement in risk prediction and a better patient selection in future clinical trials to assess a personalized therapy (i.e., prospective enrollment based on a biological/molecular signature). conditions: Circulatory Shock conditions: Sepsis conditions: Cardiogenic Shock conditions: Major Trauma c... |
<|newrecord|> nctId: NCT06376305 id: 176786 briefTitle: EndoBarrier in Obstructive Sleep Apnoea Study acronym: End-OSA overallStatus: COMPLETED date: 2016-03 date: 2019-12 date: 2019-12 date: 2024-04-19 date: 2024-04-19 name: Dr Bob Ryder class: OTHER name: Association of British Clinical Diabetologists briefSummary: O... |
<|newrecord|> nctId: NCT06376292 id: Y⒛24-0106 briefTitle: A Prospective Study of Whole-Brain RT Combined With Thiotepa Sheath Injection Combined With Systemic Therapy for the Primary Disease in the Treatment of Meningeal Metastases in Solid Tumors overallStatus: RECRUITING date: 2024-02-01 date: 2026-02-01 date: 2026-... |
How works well was the combined therapy？ How safe was combined therapy？ Participants will receive whole brain radiotherapy combined with intrathecal injection of Thiotepa twice a week for a total of 4 weeks. Evaluate the efficacy and safety every 2 cycles. |
Researchers will evaluate whether this combination treatment is safe and whether it is more effective than previous studies. conditions: Solid Tumor Leptomeningeal Metastasis studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Participants will receive a... |
<|newrecord|> nctId: NCT06376279 id: 2008/351-31 briefTitle: Genetic Diagnosis in Inborn Errors of Metabolism overallStatus: ENROLLING_BY_INVITATION date: 2008-04-29 date: 2030-12-31 date: 2030-12-31 date: 2024-04-19 date: 2024-04-19 name: Region Stockholm class: OTHER_GOV name: Karolinska Institutet briefSummary: Inbo... |
The Centre for Inherited Metabolic Diseases, CMMS at Karolinska university hospital, is an integrated expert center where clinical specialists work closely together with experts in laboratory medicine, combining clinical genetics, clinical chemistry, pediatrics, neurology, and endocrinology. The center serves the whole... |
<|newrecord|> nctId: NCT06376266 id: 202305083RSC briefTitle: Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals overallStatus: RECRUITING date: 2023-10-01 date: 2023-12-29 date: 20... |
Existing research indicates that appropriate nutrition and exercise can slow the onset of sarcopenia and even increase muscle mass to reverse its effects. This study is an interventional clinical trial recruiting middle-aged and elderly patients with sarcopenia or pre-sarcopenia. The intervention involves a combination... |
<|newrecord|> nctId: NCT06376253 id: CGIZ943A12101 id: 2023-507674-41-00 type: OTHER domain: CTIS briefTitle: A Phase I Study of [177Lu]Lu-EVS459 in Patients With Ovarian and Lung Cancers overallStatus: NOT_YET_RECRUITING date: 2024-09-06 date: 2030-08-30 date: 2030-08-30 date: 2024-04-19 date: 2024-04-19 name: Novarti... |
<|newrecord|> nctId: NCT06376240 id: NL85203.068.23 briefTitle: The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes acronym: PYRAMID overallStatus: RECRUITING date: 2024-03-21 date: 2025-12-31 date: 2025-12-31 date: 2024-04-19 date: 2024-04-19 name: Maastricht University Medical Cent... |
<|newrecord|> nctId: NCT06376227 id: jamesdukeryan briefTitle: Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation overallStatus: COMPLETED date: 2020-04-01 date: 2023-05-31 date: 2023-12-28 date: 2024-04-19 date: 2024-04-22 name: Northern Jiangsu People's... |
Background The preservation of the left colic artery (LCA) during rectal cancer resection remains a topic of controversy, and there is a notable absence of robust evidence regarding the outcomes associated with LCA preservation. And the advantages of robotic-assisted laparoscopy (RAL) surgery in rectal resection remain... |
Methods Participants who underwent laparoscopic (LSC) or RAL with or without LCA preservation resection for rectal cancer between April 2020 and May 2023 were retrospectively assessed. The patients were categorized into two groups: low ligation (LL) which with preservation of LCA and high ligation (HL) which without pr... |
<|newrecord|> nctId: NCT06376214 id: 2024-02 briefTitle: Daratumumab for Patients With Light Chain Amyloidosis overallStatus: RECRUITING date: 2023-01-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-19 date: 2024-04-19 name: Nanjing University School of Medicine class: OTHER briefSummary: This is a prospective, sing... |
<|newrecord|> nctId: NCT06376201 id: NFEC-2024-018 briefTitle: A Clinical Study on the Efficacy and Safety of ABCD in the Treatment of Patients With Invasive Fungal Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-09 date: 2024-04-19 date: 2024-04-19 name: Nanfang Hospital, Southern Medi... |
<|newrecord|> nctId: NCT06376188 id: 1582/2021 SimCom briefTitle: Improving Breaking Bad News in Pediatrics by Simulated Communication acronym: SimCom overallStatus: COMPLETED date: 2021-09-01 date: 2022-08-31 date: 2022-09-30 date: 2024-04-19 date: 2024-04-19 name: Medical University of Vienna class: OTHER briefSummar... |
This prospective, single-center, randomized controlled trial evaluated the delivery of a death notice to simulation parents out of the perspective of these parents (professional actors), the participants (students) and by video analysis. The simulation patient has prior unexpectedly died during a simulated resuscitatio... |
<|newrecord|> nctId: NCT06376175 id: LL-016 briefTitle: Task Atlas: Study to Develop a Task Atlas of Brain Recruitment During a Digital Game-based Program overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-08-31 date: 2024-08-31 date: 2024-04-19 date: 2024-04-19 name: Lumos Labs, Inc. class: INDUSTRY briefSu... |
<|newrecord|> nctId: NCT06376162 id: ITCC-101/APAL2020K id: 2023-505262-28-00 type: CTIS briefTitle: Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-08 date: 2027-08 date: 2024-04-19 date: 2024-04-19 name: LLS Pe... |
<|newrecord|> nctId: NCT06376149 id: 124973 briefTitle: M3-JIA: Making Mindfulness Matter for Children With JIA acronym: M3-JIA overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-12 date: 2026-02 date: 2024-04-19 date: 2024-04-29 name: Lawson Health Research Institute class: OTHER name: Brain Canada briefSummar... |
Measures will be obtained via questionnaires at 3 time points: baseline, 9 weeks and 2 months post-intervention. |
Additionally, at the start of each session, parents will complete a one-page semi-structured questionnaire evaluating treatment fidelity and at home utilization of M3© skills. At the end of each session, parent participants will complete a one-page structured questionnaire providing feedback on the session, and facilit... |
<|newrecord|> nctId: NCT06376136 id: BAT-8010+1006-001-CR briefTitle: An Evaluation of BAT 8010 for Injection in Combination With BAT 1006 in Locally Advanced or Metastatic Entities Safety, Tolerability, Pharmacokinetic Profile, and Initial Clinical Efficacy of the Tumor in Patients Multicenter, Open Phase Ib/IIa Clini... |
<|newrecord|> nctId: NCT06376123 id: Nkangarli001 briefTitle: Nomogram for Prediction of Alveolo-arterial Gradient During One-lung Ventilation overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-09-01 date: 2024-09-15 date: 2024-04-19 date: 2024-04-19 name: Bezmialem Vakif University class: OTHER briefSummary... |
<|newrecord|> nctId: NCT06376110 id: AviClear-001 briefTitle: Single-Blind Study Assessing the Use of a Topical Antioxidant With A Series of Laser Procedures to Reduce Sebum Production overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-04-15 date: 2025-04-15 date: 2024-04-19 date: 2024-04-19 name: Austin Ins... |
<|newrecord|> nctId: NCT06376097 id: D5162R00036 briefTitle: Lung Cancer Screening Program Using Low-dose Tomography and Metabolomic Evaluation in a Public Service. overallStatus: RECRUITING date: 2023-04-19 date: 2025-01-30 date: 2025-01-30 date: 2024-04-19 date: 2024-04-19 name: AstraZeneca class: INDUSTRY briefSumma... |
<|newrecord|> nctId: NCT06376084 id: D5161R00055 briefTitle: Osimertinib With Chemotherapy as First-line Therapy for EGFR Mutation-positive NSCLC acronym: FOREFRONT overallStatus: NOT_YET_RECRUITING date: 2024-07-24 date: 2028-02-28 date: 2028-02-28 date: 2024-04-19 date: 2024-04-19 name: AstraZeneca class: INDUSTRY br... |
<|newrecord|> nctId: NCT06376071 id: fungal rhinosiusitis briefTitle: Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis . overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-06-30 date: 2024-04-19 date: 2024-04-19 name: Assiut University class... |
1. anatomical variations and correlate radiological finding with intraoperative finding. |
2. other associated factors like demographic ,environmental, immunological and climatic risk factors . conditions: Allergic Fungal Rhinosinusitis studyType: OBSERVATIONAL observationalModel: CASE_CROSSOVER timePerspective: CROSS_SECTIONAL count: 76 type: ESTIMATED name: functional endoscopic sinus surgery measure: Sino... |
<|newrecord|> nctId: NCT06376058 id: 434/06-06-2022 briefTitle: Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section acronym: annie-mariana overallStatus: RECRUITING date: 2024-01-10 date: 2026-01-10 date: 2026-01-10 date: 2024-04-19 date: 2024-04-19 name: Aretaieion University Hospital class: OTHER brief... |
<|newrecord|> nctId: NCT06376045 id: 20220093 briefTitle: A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2026-08-10 date: 2026-10-02 date: 2024-04-19 date: 2024-04-19 name: Amgen class: INDUSTRY briefSummary: The primary objecti... |
<|newrecord|> nctId: NCT06376032 id: Akili-068 briefTitle: EndeavorOTC® Research Study in College Students overallStatus: RECRUITING date: 2024-01-10 date: 2025-12-31 date: 2025-12-31 date: 2024-04-19 date: 2024-04-23 name: Akili Interactive Labs, Inc. class: INDUSTRY name: Landmark College name: Villa Maria College br... |
\*Depending on enrollment numbers for a given semester (e.g., if \<100 students are enrolled and the study is underpowered to conduct between-group comparisons), all participants may be assigned to receive treatment immediately (i.e., single-arm design) and primary study hypotheses may be evaluated according to within-... |
<|newrecord|> nctId: NCT06376019 id: FDASU-RecID11352 briefTitle: Occlusion and Disocclusion Time in Immediately Loaded Overdentures Supported by Two Splinted Versus Non Splinted Interforaminal Implants overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-08-15 date: 2024-09-15 date: 2024-04-19 date: 2024-04-1... |
<|newrecord|> nctId: NCT06376006 id: 1798538 briefTitle: Evaluating Learning Curves and Competence in Colorectal Endoscopic Mucosal Resection Among Advanced Endoscopy Trainees acronym: EMR-STAT overallStatus: ACTIVE_NOT_RECRUITING date: 2022-05-11 date: 2024-04-01 date: 2024-12-01 date: 2024-04-19 date: 2024-04-24 name... |
<|newrecord|> nctId: NCT06375993 id: ADI-202300103 briefTitle: A Phase 1 Study of ADI-001 in Lupus Nephritis overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-12 date: 2027-12 date: 2024-04-19 date: 2024-04-19 name: Adicet Bio, Inc class: INDUSTRY briefSummary: ADI-202300103 is a phase 1 multicenter, open labe... |
<|newrecord|> nctId: NCT06375980 id: ANKARA_OR_MP briefTitle: Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing Complications overallStatus: COMPLETED date: 2022-04-01 date: 2022-12-31 date: 2022-12-31 date: 2024-04-19 date: 2024-04-19 name: Dr Abdurrahman Yurtaslan Ankara Oncology Train... |
<|newrecord|> nctId: NCT06375967 id: CARPEGIEM briefTitle: EUS-Gallbladder vs CDS as First Line in MBDO- Palliative (CARPEGIEM Trial) acronym: CARPEGIEM overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2027-06 date: 2024-04-19 date: 2024-04-19 name: Hospital Universitari de Bellvitge class: OTHER nam... |
<|newrecord|> nctId: NCT06375954 id: CARPEDIEM-2 briefTitle: EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-06-01 date: 2027-05-01 date: 2024-04-19 date: 2024-04-19 name: Hospital Universitari d... |
<|newrecord|> nctId: NCT06375941 id: ProStars briefTitle: Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars acronym: ProStars overallStatus: RECRUITING date: 2024-03-29 date: 2029-04-01 date: 2034-04-01 date: 2024-04-19 date: 2024-04-19 name: Italian Sarcoma Group class: NETWORK briefSumma... |
<|newrecord|> nctId: NCT06375928 id: CARPEDIEM-1 briefTitle: EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-02-01 date: 2026-05-01 date: 2024-04-19 date: 2024-04-19 name: Hosp... |
<|newrecord|> nctId: NCT06375915 id: PM-CARE id: PNRR-MAD-2022-12375905 type: OTHER_GRANT domain: Italian Ministry of Health briefTitle: Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy acronym: PM-CARE overallStatus: NOT_YET_RECRUITING date: 2024-04... |
<|newrecord|> nctId: NCT06375902 id: 2022289RNA briefTitle: The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them acronym: FRAME overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-10 date: 2025-10 date: 2024-04-19 date: 2024-04-19 name: IRCCS San Raffaele class: OTHER briefSummary: Tracki... |
<|newrecord|> nctId: NCT06375889 id: 69HCL24_0250 id: 2024-A00796-41 type: OTHER domain: ID-RCB briefTitle: Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage acronym: APICRASH overallStatus: NOT_YET_RECRUITING date: 2024-05-13 date: 2025-06-13 date: 2025-06-13 date: 2024-0... |
Vascular dysfunction is mediated by a loss of homeostasis between endothelial cells and figurative blood cells, including platelets. However, the interrelationship between these elements and the precise chronology of the dysfunction remain imperfectly described to date. |
It therefore seems appropriate to propose temporal monitoring of platelet activation kinetics over time, combined with concomitant collection of markers of endothelial damage, in order to clarify the vascular chronobiology of this pathology. conditions: Aneuvrysmal Subarachnoid Hemorrhage conditions: Delayed Cerebral I... |
<|newrecord|> nctId: NCT06375876 id: 2000034173 id: 15JOVW-22-GG-04755-STOP type: OTHER_GRANT domain: Office on Violence Against Women (OVW) briefTitle: Single Session Intervention to Promote Hope overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-19 date: 2024-04-26 name: Yale Un... |
<|newrecord|> nctId: NCT06375863 id: 44-2023 briefTitle: QT Changes in Geriatric Patients: a Comparison of Spinal and General Anesthesia overallStatus: COMPLETED date: 2023-03-29 date: 2023-05-29 date: 2023-05-29 date: 2024-04-19 date: 2024-04-19 name: Haseki Training and Research Hospital class: OTHER briefSummary: QT... |
Spinal anesthesia can cause profound prolongation of the QTc interval due to disparity between lumbar and thoracic sympathetic activity following subarachnoid block. Meanwhile inhalational anesthetics, sevoflurane, isoflurane, and desflurane are known to prolong QTc interval and intravenous anesthetics such as propofol... |
Over the years it has been occurred an increase in the proportion of elderly population requiring surgical anesthesia. The incidence of ventricular arrhythmias increases in advancing age even in the absence of underlying heart disease and elderly patients have reduced physiological functions and poor tolerance to anest... |
To the best of knowledge, there was no published study to compare spinal anesthesia and inhalational anesthesia in elderly patients with regard to the QT interval changes. Investigators aimed to investigate the effects of spinal anesthesia on QT, QTc intervals and to compare general anesthesia with sevofluran in elderl... |
<|newrecord|> nctId: NCT06375850 id: Effects of topical sesame oil briefTitle: Effects of Topical Sesame Oil in the Prevention of Peripheral Venous Catheter Phlebitis: Clinical Trial. overallStatus: RECRUITING date: 2022-06-05 date: 2025-02-11 date: 2025-05-11 date: 2024-04-19 date: 2024-04-19 name: Hospital Universita... |
For the treatment of these patients a venous access is required, which in the first treatments is of peripheral insertion. These peripheral venous catheter in combination with the highly aggressive treatments for the veins are the cause of the appearance of chemical phlebitis. |
Phlebitis is an inflammation caused by a combination of factors, whether chemical, perfusion of irritating medication; mechanical, due to the puncture site, type and fixation of the catheter and infectious, caused by the colonization of pathogenic agents whose origin is the skin and that migrate inward. |
Phlebitis involves an injury to the wall of the vein, and consequently, the patient will also be at risk of thrombus formation, which in turn leads to thrombophlebitis, deep vein thrombosis or pulmonary embolism. |
The existence of phlebitis involves intense and constant pain, with increased sensitivity and a sensation of heat and swelling. |
With the use of topical sesame oil, and thanks to its anti-inflammatory properties, the investigators intend to study whether it is effective in preventing the appearance of phlebitis. conditions: Phlebitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTIO... |
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