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The Family Check-Up (FCU) Online app, which was created specifically to promote positive parenting skills in parents with past or current substance misuse, is ideal for delivery to parents with pre-school age children in a pediatric primary care setting as it is brief, convenient, and delivered in a self-directed forma... |
In this study, investigators will partner with pediatric primary care providers to recruit parent participants, then evaluate feasibility and acceptability by systematically assessing parents' engagement with the FCU Online app. Engagement data from the app includes time spent in app overall and in each module, activit... |
A second aim of this study is to assess pediatric healthcare providers' perceptions and attitudes regarding the fit of the FCU Online with their practice settings as well as potential barriers to implementation. Through semi-structured focus groups and qualitative interviews with pediatric healthcare providers, investi... |
<|newrecord|> nctId: NCT06273215 id: DCTC-IIR202217 briefTitle: Evaluation of the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Diabetic Patients overallStatus: RECRUITING date: 2023-03-05 date: 2025-12-31 date: 2025-12-31 date: 2024-02-22 date: 2024-02-22 name: Pek... |
<|newrecord|> nctId: NCT06273202 id: 6257 briefTitle: Ultrasound Monitoring of Muscle Thickness in Premature Patients acronym: NeoMassage overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2024-07 date: 2025-01 date: 2024-02-22 date: 2024-02-22 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class:... |
The main questions it aims to answer are: |
* To assess by musculoskeletal ultrasound the impact of infant massage on muscle thickness muscle. Specifically, changes in muscle thickness and trophism of the quadriceps femoris. |
* Potential effects on spontaneous motility and stature-ponderal growth of infants. In addition, the discomfort and behavioral status of the infant before and after massage will be investigated infant. |
Patients included in the study will be randomized according to a random sequence with a 1:1 ratio into theexperimental group (GS) or the control group (GC). Patients in the GS will perform therapy with infant massage in addition to the usual rehabilitation therapies as specified by the program individual habilitative, ... |
Infant massage will be performed three times a day (10 minutes per session) until they reach the 35th week of post-conceptional age (35+6) by the two departmental physical therapists (ADP and ADV). |
Ultrasound will be performed at the time of randomization (T0) and then 1 time per week until the 35th week by two operators (SN and VA); at the same time, the circumference of the thigh subjected to ultrasound examination. A 12Hz linear ultrasound probe will be used, applied perpendicular to the skin. The infant will ... |
<|newrecord|> nctId: NCT06273189 id: 2017/558 briefTitle: Ultrasonic Bone Scalpel in BSSO overallStatus: COMPLETED date: 2018-12-15 date: 2020-12-15 date: 2021-12-15 date: 2024-02-22 date: 2024-02-22 name: TC Erciyes University class: OTHER briefSummary: The conventional saw compared with the piezo surgery in BSSO to e... |
<|newrecord|> nctId: NCT06273176 id: MEC-2020-0812 briefTitle: The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma acronym: RECMAP overallStatus: RECRUITING date: 2023-01-01 date: 2027-01-01 date: 2028-01-01 date: 2024-02-22 date: 2024-02-22 name: Erasmus Medical Center class: ... |
This study is an international, multicenter, prospective 3-arm cohort study of observational nature. Recurrent glioblastoma patients will be operated with mapping or no mapping techniques with a 1:1 ratio. Primary endpoints are: 1) proportion of patients with NIHSS (National Institute of Health Stroke Scale) deteriorat... |
The study will be carried out by the centers affiliated with the European and North American Consortium and Registry for Intraoperative Mapping (ENCRAM). conditions: Glioblastoma, IDH-wildtype conditions: Glioblastoma conditions: Glioblastoma Multiforme of Brain conditions: Astrocytoma, Malignant conditions: Brain Neop... |
<|newrecord|> nctId: NCT06273163 id: STU-2023-1168 briefTitle: Identifying Strategies to Curtail Weight Regain After GLP-1 Receptor Agonist Treatment Cessation overallStatus: RECRUITING date: 2024-03-05 date: 2024-12-31 date: 2024-12-31 date: 2024-02-22 date: 2024-03-08 name: University of Texas Southwestern Medical Ce... |
<|newrecord|> nctId: NCT06273150 id: 142048 briefTitle: Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study acronym: DRPLA NHBS overallStatus: RECRUITING date: 2022-05-01 date: 2026-04 date: 2026-04 date: 2024-02-22 date: 2024-02-22 name: University College, London class: OTHER name: University of... |
* To characterize the natural history of DRPLA in both juvenile- and adult-onset patients and study different modalities of biomarkers in this condition. |
* To identify genetic factors and biomarkers that could predict disease progression. |
* To provide a platform to support the design and conduct of clinical trials. |
This study has three arms: |
1. Adult Participants: this arm of the study will require participants to be 16 years old or over to participate. |
2. Pediatric Participants: this arm of the study will require participants to be under 16 years old to participate. |
3. Remote Participants: patients that cannot or do not wish to travel to one of the study sites can participate in this arm of the study, irrespective of their age. |
Participants will have an annual visit for three years (baseline visit and two follow-up visits, three visits in total). Subjects who complete the whole protocol will be assessed on two consecutive days to reduce patient burden. |
This project will allow for a better understanding of DRPLA and its course, and therefore allow for future clinical trials on this condition to be more precisely and effectively conducted. conditions: Dentatorubral-Pallidoluysian Atrophy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE c... |
<|newrecord|> nctId: NCT06273137 id: 2963 briefTitle: Positive Affect Treatment for Adolescents With Early Life Adversity acronym: PAT4ELA overallStatus: RECRUITING date: 2024-02-03 date: 2026-02-16 date: 2026-10-16 date: 2024-02-22 date: 2024-02-28 name: University of California, Irvine class: OTHER briefSummary: Yout... |
<|newrecord|> nctId: NCT06273124 id: 150-1261-00 briefTitle: Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes overallStatus: RECRUITING date: 2024-03-07 date: 2025-01-15 date: 2025-01-15 date: 2024-02-22 date: 2024-04-25 name: Tandem Diabetes Care, Inc. class: INDUSTRY name: Jaeb Center... |
Participants will be asked to: |
1. Wear the EWIS for up to 7 consecutive days for 12 consecutive wear periods |
2. Perform blood glucose and ketone measurements if continuous glucose meter is ≥250mg/dL for one hour conditions: Type1diabetes studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Device Extended Wear Infusion Set Each participant will wear each extended we... |
<|newrecord|> nctId: NCT06273111 id: 73840 briefTitle: Topical Simvastatin for Treating Infantile Hemangioma acronym: TSTIH overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-07-31 date: 2025-12-31 date: 2024-02-22 date: 2024-02-22 name: Joyce Teng class: OTHER name: Stanford University briefSummary: This is... |
The primary objective: |
To evaluate the safety and tolerability of topical treatment with 5% simvastatin ointment for superficial IH over 24 weeks. |
The secondary objective: |
1.1 To evaluate the efficacy of 5% simvastatin ointment when topical treatment is administered twice daily for 24 weeks. Evaluation is performed at each clinic visit via investigator global assessment (IGA) based on standardized 3D digital photography and hemangioma activity score (HAS). |
1.2 To evaluate the impact of 5% simvastatin ointment on quality of life using the IH-QoL questionnaire. conditions: Hemangioma Skin studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 12 type: ESTIMATED name: 5% simvastatin ointme... |
<|newrecord|> nctId: NCT06273098 id: 73162 briefTitle: School-Based Bladder Health Intervention overallStatus: WITHDRAWN date: 2028-01-01 date: 2033-12-31 date: 2033-12-31 date: 2024-02-22 date: 2024-04-24 name: Stanford University class: OTHER briefSummary: The aim of this study is to promote healthy bladder behaviors... |
<|newrecord|> nctId: NCT06273085 id: MOD00016877 briefTitle: Intensive Education Versus Usual Education of Patients for Improving Guideline Directed Medical Therapy (GDMT) Prescription in Heart Failure With Reduced Ejection Fraction overallStatus: RECRUITING date: 2024-02-01 date: 2025-02 date: 2025-02 date: 2024-02-22... |
<|newrecord|> nctId: NCT06273072 id: IRB00409080 id: R34HL166438-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/R34HL166438-01A1 briefTitle: Metformin IN Asthma for Overweight and Obese Individuals (MINA) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-09-30 date: 2028-12-31 date: 2024-02-22 da... |
<|newrecord|> nctId: NCT06273059 id: 22-07-0717 briefTitle: Genomic Study of Young-Onset Diabetes Mellitus overallStatus: RECRUITING date: 2022-09-12 date: 2024-12-12 date: 2024-12-12 date: 2024-02-22 date: 2024-02-22 name: Indonesia University class: OTHER briefSummary: Diabetes Mellitus (DM) has been a major contribu... |
Young-onset DM has a wide clinical spectrum, including autoimmune DM, polygenic DM, and monogenic DM such as Mature Onset Diabetes of the Young (MODY). Identification and proper diagnosis of young-onset DM spectrum is crucial to treatment outcomes, as certain spectrums, such as some subtypes of MODY, may benefit from c... |
However, proper diagnosis of young-onset DM in Indonesia is still a great challenge, as currently some examinations, including genetic testing, has not yet been feasibly done in the country. With current advances in genomics, genetic testing may prove to be fundamental in providing optimal and personalized treatment an... |
This study is a pilot project aimed to initiate genomic research in young-onset DM patients in Indonesia. In the short term, this study aims to identify genetic variants that may be able to increase diagnostic accuracy of the young-onset DM spectrum. In the long term, this study aims to identify new genetic variants of... |
<|newrecord|> nctId: NCT06273046 id: PR(AG)614/2023 briefTitle: Treatment of Fecal Incontinence and Functional Defecation Disorders Using Non-instrumental Biofeedback overallStatus: RECRUITING date: 2024-04-19 date: 2025-04-28 date: 2025-12-31 date: 2024-02-22 date: 2024-04-25 name: Hospital Universitari Vall d'Hebron ... |
Hypothesis. A cognitive intervention based on original audiovisual programs developed specifically for the management of anorectal functional disorders is effective in correcting anorectal function disorders that cause fecal incontinence and evacuation disorders. |
Aim. To prove in two different protocols (fecal incontinence and dyssinergic defecation) the efficacy of specifically developed non-instrumental biofeedback techniques. |
Selection criteria. Patients with fecal incontinence and altered sphincter function and patients with outlet obstructed evacuation referred for biofeedback treatment. |
Intervention. In separate studies (incontinence and dyssynergic defecation) patients will be randomized into biofeedback and placebo groups. One session of either biofeedback or placebo intervention will be performed at the beginning of the intervention period and patients will be instructed to performed the assigned d... |
Biofeedback: patients will be taught to control anal and abdominal muscular activity by providing instructions using original video supports. Patients will be instructed to perform the same exercises daily at home in scheduled times. |
Placebo: a pill of placebo containing 0.3 g glucose will be administered every day at home. conditions: Fecal Incontinence conditions: Outlet Dysfunction Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT ... |
<|newrecord|> nctId: NCT06273033 id: CONCORDE briefTitle: Implementation of Contemporary Coronary CT Angiography in Clinical Practice acronym: CONCORDE overallStatus: RECRUITING date: 2023-10-10 date: 2024-10 date: 2025-01 date: 2024-02-22 date: 2024-03-01 name: Humanitas Hospital, Italy class: OTHER briefSummary: Coro... |
The investigators aim 1) to report the real word data on the performance of last-generation CCTA in identifying obstructive coronary artery disease (also considering different thresholds of stenosis, i.e., moderate or severe) and 2) to identify predictors of discrepancies. conditions: Coronary Artery Disease of Signifi... |
<|newrecord|> nctId: NCT06273020 id: MI22-00013 briefTitle: Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke overallStatus: RECRUITING date: 2022-11-17 date: 2024-11 date: 2024-12 date: 2024-02-22 date: 2024-02-22 name: Hospital Universitario Dr. Jose E. Gonzalez class: OT... |
Group 1: 20 patients with previous intravenous thrombolysis (IVT) in the qualifying stroke and who agreed to receive and got selected (through randomization) cerebrolysin. |
Group 2 : 20 patients with previous IVT in the qualifying stroke and who agreed to receive cerebrolysin but they were not choose through randomization. |
Group 3: 20 patients that they were not candidates to receive IVT (out of therapeutic window) but agreed to receive cerebrolysin (randomization not used) primaryPurpose: SUPPORTIVE_CARE masking: NONE count: 60 type: ESTIMATED name: Cerebrolysin name: Brain-MRI with contrast after 10-14 days of cerebrolysin measure: Blo... |
<|newrecord|> nctId: NCT06273007 id: EFP_2023_02_19 briefTitle: Improving Intrapartum Care for Saving Life at Birth in Ethiopia Through PartoMa Approach acronym: PartoMa-Eth overallStatus: RECRUITING date: 2023-06-01 date: 2025-12-31 date: 2027-12-31 date: 2024-02-22 date: 2024-02-22 name: Haramaya Unversity class: OTH... |
To introduce PartoMa approach (locally agreed and achievable intrapartum guidelines and a continual in-house training program) to Ethiopian context through continuous fetal heart rate (FHR) monitoring using MOYO device and co-creation of context specific intrapartum care guideline for improving decision making in intra... |
Interventions |
1. Locally agreed and achievable intrapartum guidelines |
2. Low dose high frequency trainings (LDHF) |
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