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Research hypothesis: |
Capacitive and resistive energy transfer therapy is comparable to dry needling therapy for the treatment of myofascial trigger points. |
It is estimated that the presence of trigger points is the main cause of pain in 30-85% of patients visiting primary health care facilities and pain management clinics. The presence of trigger points may significantly affect the patient's functional status and daily functioning. Recently, diagnostic criteria and method... |
Therefore, the objectives of the work were: |
Determination and comparison of the short- and long-term effects of capacitive and resistive energy transfer therapy and the dry needling technique of myofascial trigger points located in the upper trapezius muscle (UT) on the strength, neck range of motion and pain intensity within this muscle. |
The study is planned to include a group of 26 men aged 25 to 45 who suffer from pain caused by the presence of myofascial trigger points in the upper trapezius muscle. The subjects will be divided into two groups of equal number of people. The first group will undergo therapy using the dry needling technique, while the... |
In order to determine the immediate effects of capacitive and resistive energy transfer therapy and dry needling techniques, measurements of muscle strength, the intensity of pain in the upper trapezius muscle and neck range of motion will be performed before and after each therapeutic session (2 session in 2 weeks are... |
<|newrecord|> nctId: NCT06273501 id: D-NR 2022-02876-01 briefTitle: MRI and Magnetometer-guided Sentinel Lymph Node Detection in Vulvar Cancer acronym: POSVUC overallStatus: ENROLLING_BY_INVITATION date: 2022-03-24 date: 2024-12-01 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Sahlgrenska University Hospital... |
<|newrecord|> nctId: NCT06273488 id: EXZL20240002 briefTitle: The Role of Auricular Point Diagnosis and Treatment in ERAS During TKA overallStatus: RECRUITING date: 2024-03-23 date: 2024-11-01 date: 2024-12-01 date: 2024-02-22 date: 2024-04-08 name: Peking Union Medical College class: OTHER briefSummary: To further imp... |
<|newrecord|> nctId: NCT06273475 id: OUH RoboRehab briefTitle: Robot-Assisted Training Versus Standard Training in Ischemic Stroke overallStatus: RECRUITING date: 2024-05-01 date: 2025-03-01 date: 2027-02-01 date: 2024-02-22 date: 2024-04-18 name: Odense University Hospital class: OTHER name: University of Southern Den... |
The main hypothesis of the study is: |
Robot-assisted training has a superior effect on motor function (Fugl-Meyer Lower Extremity Assessment; primary outcome), physical function, fatigue, and quality of life in moderately-to-severely impaired chronic stroke-affected individuals in comparison to standard training. conditions: Stroke conditions: Ischemic Str... |
<|newrecord|> nctId: NCT06273462 id: NMCSD.2024.0006 briefTitle: Palmitoylethanolamide for Chronic Inflammatory Pain Conditions overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-05-30 date: 2024-02-22 date: 2024-02-22 name: Navy Medical Center San Diego class: FED briefSummary: The goal of ... |
Participants will be divided into two equal groups and asked to take either PEA or a placebo for 8 weeks. conditions: Chronic Pain studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Prospective Randomize Double Blind Placebo Controlled study compari... |
<|newrecord|> nctId: NCT06273449 id: 385/2023 briefTitle: A Smart Digital Workflow Towards High Precision and Through-Put Production for Removable Partial Dentures overallStatus: RECRUITING date: 2022-12-29 date: 2024-08-30 date: 2024-08-30 date: 2024-02-22 date: 2024-02-22 name: National Dental Centre, Singapore class... |
2. Partial digital workflow: Adopts the same teeth profile capture method, where a physical impression of teeth profile is taken from the subject. However, instead of using physical wax pattern on the stone model for design, the stone model is scanned and, on the scan, the design is performed digitally. For fabrication... |
3. SmartRPD digital workflow Adopts a different teeth profile capture method by using the intraoral scanner to digitally scan and save the subject's teeth profile. From the intraoral scan, a digital model of the subject's teeth profile is created but on the digital model instead, the design of RPD is digitally performe... |
<|newrecord|> nctId: NCT06273436 id: Pro00130902 briefTitle: Healing, Equity, Advocacy and Respect for Mamas acronym: HEAR4Mamas overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2028-11-30 date: 2028-11-30 date: 2024-02-22 date: 2024-04-22 name: Medical University of South Carolina class: OTHER name: Patient-Ce... |
<|newrecord|> nctId: NCT06273423 id: OULA for Postpartum Depression briefTitle: Feasibility Evaluation of a Dance Fitness Program overallStatus: NOT_YET_RECRUITING date: 2024-10 date: 2025-05 date: 2025-06 date: 2024-02-22 date: 2024-02-22 name: Montana State University class: OTHER briefSummary: The objective of this ... |
<|newrecord|> nctId: NCT06273410 id: 0453-6/2022 briefTitle: Clinical Performance of An Alkasite Based Restorative Material With And Without Adhesive overallStatus: COMPLETED date: 2022-10-13 date: 2023-11-28 date: 2023-11-28 date: 2024-02-22 date: 2024-02-22 name: Hams Hamed Abdelrahman class: OTHER briefSummary: Desp... |
<|newrecord|> nctId: NCT06273397 id: ACME-AHF briefTitle: Acetazolamide or Metolazone in Acute Heart Failure acronym: ACME-AHF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-03-01 date: 2027-05-01 date: 2024-02-22 date: 2024-03-18 name: Clinica Alemana de Santiago class: OTHER briefSummary: Impact of Acu... |
According to the World Health Organization (WHO), approximately 26 million people suffer from Heart Failure (HF), with a mortality rate of up to 50% within five years of diagnosis. Acute Heart Failure (AHF) exacerbations, leading to hospitalization, are common and represent the primary cause of hospital admissions in t... |
Use of Diuretics in Acute Heart Failure: |
Diuretics, particularly loop diuretics like furosemide, are a cornerstone in managing AHF by inducing natriuresis and achieving decongestion. Clinical experience supports their use, though limited clinical trials exist. Pharmacological concepts guide their administration, emphasizing intravenous delivery in high doses ... |
Use of Metolazone and Acetazolamide: |
Sequential tubular blockade, using metolazone and acetazolamide in conjunction with furosemide, aims to achieve rapid and effective decongestion. While metolazone targets the distal tubule, inhibiting sodium-chloride channels, acetazolamide affects proximal tubular function. Studies like ADVOR (acetazolamide) and CLORO... |
Outcomes Measured by Major Studies: |
Recent studies assessing decongestion in AHF reveal a lack of uniformity in outcome selection. The primary focus should be on reducing rehospitalizations and post-discharge mortality by achieving effective decongestion. The ADVOR study, using a simple congestion score based on clinical and imaging criteria, underscores... |
Congestion Monitoring: |
Monitoring diuretic treatment solely based on clinical aspects may not capture subclinical congestion, necessitating biochemical and imaging parameters. The ACME-AHF trial proposes a diagnostic score integrating clinical and imaging aspects to evaluate congestion status. Secondary outcomes include cumulative diuresis, ... |
Aim of the study: |
The ACME-AHF trial is designed to compare the efficacy and safety of two diuretic combination strategies: acetazolamide with furosemide and metolazone with furosemide. The primary objective is to relieve congestion, assessed using a congestion score, within the first three days of treatment during an hospitalization fo... |
<|newrecord|> nctId: NCT06273384 id: Si 062/2023 briefTitle: Diagnostic Performance of CIM for Helicobacter Pylori Infection in Patients With Peptic Ulcer Bleeding acronym: CIM overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-09-30 date: 2024-12-31 date: 2024-02-22 date: 2024-02-22 name: Mahidol University... |
* To evaluate the efficacy of CIM method for H. pylori detection compared to rapid urease test(RUT), histopathology, polymerase chain reaction (PCR), and urea breath test (UBT) in patients who presented with upper gastrointestinal hemorrhage from peptic ulcer, and their sensitivity, specificity, accuracy, positive pred... |
* To evaluate the advantages of CIM method for H. pylori detection comparing to RUT, histopathology, PCR, and UBT in patients who presented with upper gastrointestinal hemorrhage from peptic ulcer as net reclassification index (NRI). |
* To study the associated factors in false negative value of H. pylori detection methods with CIM, RUT, histopathology, PCR, and UBT. conditions: Helicobacter Pylori Infection conditions: Peptic Ulcer Hemorrhage studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 135 type: ... |
<|newrecord|> nctId: NCT06273371 id: DELISA2023 briefTitle: Tolerance and Growth Outcomes in Children Diagnosed With Cow's Milk Protein Allergy and Prescribed an Extensively Hydrolyzed Casein Formula (Damira 2000©) in Spain acronym: DELISA overallStatus: COMPLETED date: 2023-12-12 date: 2023-12-21 date: 2023-12-21 date... |
<|newrecord|> nctId: NCT06273358 id: Study Sleep Quality briefTitle: Preoperative Sleep Quality and Postoperative Delirium overallStatus: COMPLETED date: 2023-08-01 date: 2023-12-18 date: 2024-01-27 date: 2024-02-22 date: 2024-02-22 name: Konya City Hospital class: OTHER briefSummary: Background: Delirium is a neurocog... |
Methods: Between August 1st and December 5th, 2023, 124 patients undergoing non-cardiac general anesthesia (mean age 63.68 ± 8.81 years \[SD\]; range 46-82 years) reported on their sleep characteristics. PSQI, 1- sleep duration, 2- sleep disturbance, 3- sleep latency, 4- daytime dysfunction resulting from sleepiness, 5... |
<|newrecord|> nctId: NCT06273345 id: IOV-PR-1-2022-OLIGOS briefTitle: OLIGOS: Impact of Treatment on Primary Tumour in Patients With Newly Diagnosed Oligometastatic Neoplasia of the Prostate acronym: OLIGOS overallStatus: RECRUITING date: 2023-01-23 date: 2025-01 date: 2025-01 date: 2024-02-22 date: 2024-02-22 name: Is... |
The aim of the study is the creation of a registry including patients with newly diagnosed OMPCa, belonging to the main urological centres in the Triveneto region, in order to evaluate the oncological outcomes and the impact on the quality of life of local treatment of the primary neoplasm (surgical or radiotherapy) in... |
The above criteria define 'high metastatic volume' disease with the following parameters |
* ≥ 4 bone metastases, including at least one outside the spine and pelvis |
* Presence of visceral metastases Consequently, patients included in the study should not have the above-mentioned characteristics. conditions: Oligometastatic Prostate Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED measure: Overall survival (OS) me... |
<|newrecord|> nctId: NCT06273332 id: AI surgery protocol briefTitle: Assessment of the Artifical Intelligence Assisted Registration Versus Conventional Point Based Registration on Cone Beam-computed Tomography (CBCT) With Heavy Metal Artifacts overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-20 date: 2024-01-20 date:... |
<|newrecord|> nctId: NCT06273319 id: 010656 briefTitle: The Effect of Oxygen Application With Double Nasal Cannula on Respiratory Complications overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-05-01 date: 2024-06-01 date: 2024-02-22 date: 2024-02-22 name: Inonu University class: OTHER briefSummary: To comp... |
<|newrecord|> nctId: NCT06273306 id: HULP.PI-4519 id: PI22/00777 type: OTHER_GRANT domain: Fondo de investigaciones sanitarias.Instituto de Salud Carlos III briefTitle: Towards Telemonitoring in Immune-Mediated Inflammatory Diseases: Implementation of a Mixed Attention Model (IMIDOC) acronym: IMIDOC overallStatus: NOT_... |
This is a multicenter prospective observational study involving 360 patients with rheumatoid arthritis (RA) and Spondylarthritis (SpA) from five Spanish Hospitals. Patients will be followed-up by the MAM protocol, which is a care model that incorporates the use of digital tool consisting of a mobile application (App) t... |
<|newrecord|> nctId: NCT06273293 id: EPIC35-PROMETEUS briefTitle: Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL) overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2025-01-20 date: 2026-01-20 date: 2024-02-22 date: 2024-03-13 name: Funda... |
In recent years, functional assessment after intervention has also been increasingly implemented, which, like intracoronary imaging, can make us change our attitude and correlate with the prognosis. The lower implementation of this practice, especially in multivessel patients, may result from having to lose the positio... |
The purpose of this study is to evaluate the correlation between cFFR-NTG and other indices taking FFR as a reference in multivessel patients after undergoing intervention. Establish cut-off points and correlate it with adverse cardiovascular events (MACE) in a 1-year clinical follow-up. conditions: Coronary Disease st... |
<|newrecord|> nctId: NCT06273280 id: Z-2023025 briefTitle: Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction. acronym: ReQUAD-HF overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-14 date: 2025-12 date: 2026-03 date: 2024-02-22 date: 2024-02-28 name: Ziekenhuis ... |
Participants will be randomized towards control (standard of care, SOC) or intervention group. |
Researchers will compare SOC with protocol-based up-titration to see if the protocolized optimization improves prescription rate of GDMT. conditions: Heart Failure conditions: Heart Failure With Reduced Ejection Fraction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventio... |
<|newrecord|> nctId: NCT06273267 id: APHP231232 briefTitle: Initiating Pediatric Palliative Care in ACT Group 4 acronym: StartSPP overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2024-08 date: 2024-08 date: 2024-02-22 date: 2024-02-22 name: Assistance Publique - Hôpitaux de Paris class: OTHER briefSummary: Due to ... |
This classification includes four groups. ACT 4 category is made up of children with a serious incurable non-progressive neurological disease (for example: anoxic ischemia, cerebral palsy, traumatic or infectious brain injuries). |
Although data relating to specific ACT groups are scarce, experience from clinical practice suggests that the needs and use of Pediatric palliative care resources are different across the four categories. |
The specific history of ACT-4 patients suggests that pediatric palliative care may be required early on in the history of the disease but effective intervention varies greatly from one patient to another. Tthis study aims to better understand the optimal timing for introducing a PPC team into the care pathway for these... |
<|newrecord|> nctId: NCT06273254 id: SCVL-TFZ-1009 briefTitle: A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-09 date: 2024-02-22 date: 2024-02-22 name: Viatris Inc. class: INDUSTRY briefSummary: Primar... |
<|newrecord|> nctId: NCT06273241 id: IPHA-2024-009 briefTitle: Impact of Food Intake on Berberine Kinetics acronym: BERKI-3 overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2024-09-30 date: 2024-09-30 date: 2024-02-22 date: 2024-02-22 name: University Medicine Greifswald class: OTHER briefSummary: The influence... |
In both BERKI-1 and 2 studies, the plasma concentration curve exhibited two peaks. The first after about 2-3 h, and the second after approximately 5 h of berberine intake. All participants took a single dose of Berberine under fasting conditions in the morning and 4 h after berberine intake, they ate a meal. Shortly af... |
As in BERKI-1 and 2, time dependent blood and urine samples will be collected after a single berberine dose. One By measuring berberine metabolites by Liquid Chromatography and Mass-spec One dose will be taken in the fasted condition and the other two after a light or high caloric meal, respectively. |
24 heathy volunteers with an equal ratio of man and women will be enrolled. conditions: Pharmacokinetic Study in Healthy Volunteers studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: This is an unblinded, randomized, prospective study comparing berberi... |
<|newrecord|> nctId: NCT06273228 id: STUDY00000788 briefTitle: Parenting Young Children in Pediatrics overallStatus: RECRUITING date: 2023-09-27 date: 2024-10-01 date: 2024-10-01 date: 2024-02-22 date: 2024-02-22 name: University of Oregon class: OTHER name: National Institute on Drug Abuse (NIDA) briefSummary: Researc... |
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