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<|newrecord|> nctId: NCT06383871 id: HRS-7058-101 briefTitle: A Phase I Clinical Study of HRS-7058 in Patients With Advanced Malignant Tumour overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-06 date: 2026-06 date: 2024-04-25 date: 2024-04-25 name: Shandong Suncadia Medicine Co., Ltd. class: INDUSTRY briefSumm... |
<|newrecord|> nctId: NCT06383858 id: [2023] Ethics Review NO.151 briefTitle: The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center overallStatus: RECRUITING date: 2023-08-01 date: 2028-12-31 date: 2028-12-31 date: 2024-04-25 date: 2024-04-25 name: The Third Affiliated Hospital of Guan... |
Therefore, early prediction of preeclampsia and targeted strengthening of high-risk pregnant women supervision, early intervention and diagnosis and treatment can greatly reduce the serious obstetric complications and perinatal maternal and fetal deaths caused by preeclampsia, which has significant social and clinical ... |
<|newrecord|> nctId: NCT06383845 id: MAS ESLI briefTitle: Comparison of Erector Spinae Plane Block vs Intravenous Lidocaine for Chronic Pain Post Mastectomy. overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2024-01-31 date: 2024-09-30 date: 2024-04-25 date: 2024-04-25 name: University Tunis El Manar class: O... |
For Lido-IV group, patients received a loading dose of Lidocaine than a continuous infusion till the end of surgery. |
For ESP group, an ultrasound guided ESP Block was perormed before anesthetic induction. |
Persistant pain post mastectomy was assessed by SFM-PQ score at 1, 3 and 6 months post surgery. conditions: Breast Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Erector spinae plane block VS intravenous lidocaine. primaryPurpose: PREVENTION... |
<|newrecord|> nctId: NCT06383832 id: 20240310_GY briefTitle: Effect of Dapagliflozin on Body Weight in Overweight Women Consuming Different Proportions of Carbohydrate Diet. overallStatus: COMPLETED date: 2021-10-28 date: 2023-12-26 date: 2023-12-26 date: 2024-04-25 date: 2024-04-25 name: Sun Jia class: OTHER briefSumm... |
<|newrecord|> nctId: NCT06383819 id: Long-Cov-III-21 briefTitle: Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19 overallStatus: COMPLETED date: 2022-04-08 date: 2023-12-31 date: 2023-12-31 date: 2024-04-25 date: 2024-04-25 name: NPO Petrovax class: INDUS... |
<|newrecord|> nctId: NCT06383806 id: STU00219933 id: 315-SR-23 type: OTHER_GRANT domain: American Academy of Sleep Medicine Foundation briefTitle: Decreasing Nightmares in Adults With Narcolepsy acronym: DAWN overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-09 date: 2026-09 date: 2024-04-25 date: 2024-04-25 n... |
<|newrecord|> nctId: NCT06383793 id: Northjiangsu000 briefTitle: Comparative Analysis of Short-Term Therapeutic Effects Between the π-Shaped and Overlap Methods for Esophagogastrostomy in Totally Laparoscopic Total Gastrectomy overallStatus: RECRUITING date: 2024-04-01 date: 2024-08-30 date: 2025-12-30 date: 2024-04-25... |
This article aims to explore the differences in the short-term therapeutic effects, surgical effectiveness, and safety between laparoscopic total gastrectomy with esophagogastrostomy using the overlap method and the π-shaped method. The goal is to provide new reference points for surgeons in the clinical decision-makin... |
<|newrecord|> nctId: NCT06383780 id: SYSKY-2023-901-01 briefTitle: Tislelizumab in Combination With GP or TPC Regimen for the Treatment of Nasopharyngeal Carcinoma With Bone Metastasis. overallStatus: RECRUITING date: 2024-05-01 date: 2027-05-01 date: 2027-05-01 date: 2024-04-25 date: 2024-04-25 name: XIANG YANQUN clas... |
<|newrecord|> nctId: NCT06383767 id: ESG401-301 briefTitle: A Phase III Study of ESG401 for Locally Advanced or Metastatic HR+/HER2- Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2026-07-31 date: 2026-12-31 date: 2024-04-25 date: 2024-04-25 name: Shanghai Escugen Biotechnology Co., Ltd class: I... |
<|newrecord|> nctId: NCT06383754 id: Clove briefTitle: Clareon Intraocular Lens Stability in Vitrectomy Patients: CLOVE Study overallStatus: COMPLETED date: 2021-06-07 date: 2024-03-08 date: 2024-03-15 date: 2024-04-25 date: 2024-04-25 name: The University of Hong Kong class: OTHER briefSummary: This prospective random... |
<|newrecord|> nctId: NCT06383741 id: 2023-00541 briefTitle: Predicting Outcomes in ICH Patients on Direct Factor Xa Inhibitors acronym: FIRE-Xa overallStatus: RECRUITING date: 2023-07-10 date: 2026-04-01 date: 2026-04-01 date: 2024-04-25 date: 2024-04-25 name: Insel Gruppe AG, University Hospital Bern class: OTHER brie... |
Treatment options for factor-Xa inhibitor-associated ICH, such as prothrombin complex concentrate (PCC) and andexanet alfa, lack direct comparison evidence except for ongoing trials like ANNEXA-I. This trial assesses hemostatic efficacy and 30-day functional outcomes but leaves gaps regarding anticoagulant activity's r... |
The measurement of anti-FXa levels helps guide decisions, yet their link to hematoma expansion remains unknown. Efforts to streamline measurement within 30 minutes for acute decisions have shown variability in levels, with some patients exhibiting high levels even beyond 12 hours post-intake. This lack of data poses ch... |
Early hematoma expansion strongly predicts poor outcomes, but preventing it faces challenges like recurrent events (up to 5% by 3 months) and rehabilitation intensity, potentially negating its benefits. The ANNEXA-I trial evaluates short-term outcomes, highlighting the need for additional data to comprehend long-term I... |
The study's objectives involve linking hematoma expansion to anti-FXa levels, determining late-presenting patients' risk of expansion, and identifying predictors of favorable outcomes at 3, 6, and 12 months. Primary endpoints include functional outcomes, while secondary ones encompass expansion rates, anticoagulant act... |
This research aims to bridge gaps in understanding factor-Xa inhibitor-related ICH, addressing both immediate and prolonged outcomes to enhance clinical decision-making. conditions: Intra Cerebral Hemorrhage studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED meas... |
<|newrecord|> nctId: NCT06383728 id: ES-2024-014-02 briefTitle: Osimertinib as Neoadjuvant Therapy in Patients With Resectable Stage II-IIIB EGFR-mutated Lung Squamous Cell Carcinoma acronym: GALAXY-02 overallStatus: RECRUITING date: 2024-04-01 date: 2025-10-31 date: 2029-04-30 date: 2024-04-25 date: 2024-04-25 name: T... |
<|newrecord|> nctId: NCT06383715 id: 2024-624 briefTitle: Congitive Behavioral Therapy Workshop for Content Moderators overallStatus: RECRUITING date: 2024-05-01 date: 2024-06-01 date: 2024-08-01 date: 2024-04-25 date: 2024-04-26 name: Universidad Europea de Valencia class: OTHER briefSummary: Professional content mode... |
<|newrecord|> nctId: NCT06383702 id: HEX1939-002 briefTitle: Phase III Trial to Evaluate the Efficacy and Safety of Pregabalin in the Treatment of Painful Diabetic Peripheral Neuropathy overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-04-01 date: 2025-04-15 date: 2024-04-25 date: 2024-04-25 name: CSPC Ouyi... |
<|newrecord|> nctId: NCT06383689 id: Az. 297/23-EP briefTitle: Placebo Optimization of the Presurgical Long-term Video-EEG Monitoring acronym: OPERA overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-12-31 date: 2024-04-25 date: 2024-04-25 name: University Hospital, Bonn class: OTHER briefSu... |
<|newrecord|> nctId: NCT06383676 id: 1 briefTitle: Effect Of Functional Balance Exercise İn Elderly acronym: RCT overallStatus: ACTIVE_NOT_RECRUITING date: 2023-04-20 date: 2024-11-30 date: 2025-05-30 date: 2024-04-25 date: 2024-04-25 name: Tarsus University class: OTHER briefSummary: The elderly population is increasi... |
<|newrecord|> nctId: NCT06383663 id: 308-2019-04-01 briefTitle: A RCT of Supraclavicular Lymph Node Dissection vs. No-dissection in Supraclavicular Lymph Node Metastatic Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-12-31 date: 2029-12-31 date: 2024-04-25 date: 2024-04-25 name: Sun Yat-sen... |
<|newrecord|> nctId: NCT06383650 id: 124532 briefTitle: Use of 81 vs 325mg of ASA in Treatment of BCVI overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-05 date: 2025-09 date: 2024-04-25 date: 2024-04-25 name: London Health Sciences Centre class: OTHER name: Western University briefSummary: Blunt cerebrovascul... |
Currently, there is wide variation across centers and trauma care providers in treatment strategies for BCVI and the most recent guidelines are unable to make specific recommendations about the optimal agent and/or dose of treatment to reduce the risk of stroke after BCVI while minimizing bleeding complications in pati... |
This project will investigate two doses of antiplatelet therapy (81 mg daily vs. 325 mg daily aspirin) for BCVI treatment, and will look at the risk of stroke and bleeding complications with each strategy. The goal of the research is to determine whether a large-scale study looking at this question is feasible, which w... |
<|newrecord|> nctId: NCT06383637 id: KAP-ABR-Interns briefTitle: Antibiotic Use and Resistance KAP Among Dental Interns overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-11-01 date: 2024-12-01 date: 2024-04-25 date: 2024-04-25 name: Cairo University class: OTHER briefSummary: The study is designed as a cros... |
<|newrecord|> nctId: NCT06383624 id: RC18-4-2023 briefTitle: Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis overallStatus: COMPLETED date: 2023-04-01 date: 2024-03-01 date: 2024-03-31 date: 2024-04-25 date:... |
<|newrecord|> nctId: NCT06383611 id: OTX-0303 briefTitle: Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty acronym: APEX-EAP overallStatus: AVAILABLE date: 2024-04-25 date: 2024-04-25 name: Osteal Therapeutics, Inc. class: INDUSTRY briefSummary: The objective of the protocol is to provi... |
<|newrecord|> nctId: NCT06383598 id: 2022KT74-ZY01 briefTitle: PD-L1 Specific [68Ga]-Nb-1 Nanobody Probe for PET Imaging in Solid Tumors overallStatus: RECRUITING date: 2024-05-09 date: 2026-12 date: 2026-12 date: 2024-04-25 date: 2024-04-25 name: Peking University Cancer Hospital & Institute class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06383585 id: 24-001367 briefTitle: 3D DL Ozteo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2026-12 date: 2024-04-25 date: 2024-04-25 name: Mayo Clinic class: OTHER name: GE Healthcare briefSummary... |
<|newrecord|> nctId: NCT06383572 id: 2024-0196 id: NCI-2024-03505 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: Phase I/II Study of Engineered T Cell Receptor-Modified NK Cells Targeting PRAME in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Myeloid Malignancies ove... |
<|newrecord|> nctId: NCT06383559 id: TJMUCH-GI-GC07 briefTitle: Safety and Efficacy of XELOX Combined With Sintilimab and Lenvatinib in Advanced AFP-positive Gastric Cancer Patients overallStatus: RECRUITING date: 2023-12-01 date: 2026-07-01 date: 2026-09-01 date: 2024-04-25 date: 2024-04-25 name: Tianjin Medical Unive... |
<|newrecord|> nctId: NCT06383546 id: XHEC-C-2024-053-1 briefTitle: Artificial Intelligence-enabled ECG Detection of Congenital Heart Disease in Children: a Novel Diagnostic Tool acronym: AI-ECG-CHD overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-30 date: 2025-12-30 date: 2024-04-25 date: 2024-04-25 name: Xinhu... |
<|newrecord|> nctId: NCT06383533 id: IRB-2023-385 briefTitle: Disitamab Vedotin Plus Cadonilimab in Patients With HER2 Mutant Advanced or Metastatic Bile Duct Adenocarcinoma overallStatus: RECRUITING date: 2023-05-01 date: 2025-05-01 date: 2025-12-31 date: 2024-04-25 date: 2024-04-26 name: Zhejiang Cancer Hospital clas... |
<|newrecord|> nctId: NCT06383520 id: XLan-0415 briefTitle: Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma overallStatus: RECRUITING date: 2023-09-30 date: 2024-12-30 date: 2025-12 date: 2024-04-25 date: 2024-04-25 name: Wuhan Union Hospital, China class: OTHER briefSum... |
<|newrecord|> nctId: NCT06383507 id: CHT101 briefTitle: A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2027-04-21 date: 2029-04-21 date: 2024-04-25 date: 2024-04-25 name: Zhejiang University class: OTHER briefSummary: This is a single... |
<|newrecord|> nctId: NCT06383494 id: IRB-2024-356（IIT） briefTitle: GMA-TulipTM, i-gelTM and the LMA-SupremeTM (LMA-S) Devices in Airway Management overallStatus: RECRUITING date: 2024-04-30 date: 2025-12-30 date: 2025-12-30 date: 2024-04-25 date: 2024-04-26 name: Zhejiang Cancer Hospital class: OTHER briefSummary: Pati... |
<|newrecord|> nctId: NCT06383481 id: TDK-2024-13362 briefTitle: The Effect of Mobile-Based Education on Postoperative Recovery and Quality of Life in Thyroidectomy Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-04-22 date: 2025-08-22 date: 2024-04-25 date: 2024-04-26 name: Ataturk University cla... |
Patients who have had thyroidectomy are discharged within 1-2 days after surgery if no problems occur. For this reason, patient education provided by health professionals and especially nurses may be insufficient. Post-discharge patient education in surgical services can sometimes be ignored, and it is noteworthy that ... |
In this study, a mobile application that covers the entire perioperative process and includes education will be developed for patients undergoing thyroidectomy. This developed mobile application aims to manage post-operative problems such as neck pain and discomfort and voice changes experienced by patients, and to imp... |
<|newrecord|> nctId: NCT06383468 id: AK120-301 briefTitle: A Phase III Study to Evaluate the Efficacy and Safety of AK120 in Patients With Moderate to Severe Atopic Dermatitis overallStatus: RECRUITING date: 2024-04-30 date: 2025-01-30 date: 2026-01-30 date: 2024-04-25 date: 2024-04-25 name: Akeso class: INDUSTRY brief... |
<|newrecord|> nctId: NCT06383455 id: Observational briefTitle: Effects of Smoking on Clinical and Microbiological Response in Individuals With Periodontitis overallStatus: COMPLETED date: 2018-09-15 date: 2019-02-01 date: 2019-03-01 date: 2024-04-25 date: 2024-04-25 name: Trakya University class: OTHER briefSummary: Th... |
- Does smoking affect the results of non-surgical periodontal treatment on subgingival flora in participants with periodontal disease? |
Researchers performed non-surgical periodontal therapy on 48 participants with stage III/IV periodontitis and recorded clinical measurements. They obtained subgingival plaque samples from periodontal pockets at the onset and after four weeks of treatment, determining the level of periodontopathogens using a polymerase ... |
<|newrecord|> nctId: NCT06383442 id: N202103041 briefTitle: HIIT on Overweight Middle-aged Adults acronym: HIIT overallStatus: COMPLETED date: 2021-05-25 date: 2023-07-31 date: 2023-11-22 date: 2024-04-25 date: 2024-04-25 name: Taipei Medical University class: OTHER briefSummary: 36 middle-aged with overweight adults w... |
<|newrecord|> nctId: NCT06383429 id: P.T-WH-10/2023-521 briefTitle: Relation Between Forward Head Posture and Incidence of Headache in Obese Adults overallStatus: COMPLETED date: 2024-01-01 date: 2024-03-14 date: 2024-04-15 date: 2024-04-25 date: 2024-04-25 name: Ahram Canadian University class: OTHER briefSummary: Cro... |
* Detailed history of patient |
* Forward head posture by using mobile application |
* Headache disability index conditions: Obese conditions: Headache conditions: Neck Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 40 type: ACTUAL name: forward head posture by using mobile application. And patients will fill out headache disability index. measure: forwar... |
<|newrecord|> nctId: NCT06383416 id: P.T-INT-10/2023-522 briefTitle: Incidence of Headache and Its Effect on Quality of Life in Geriatric Patients With Chronic Neck Pain overallStatus: COMPLETED date: 2024-01-21 date: 2024-03-20 date: 2024-04-20 date: 2024-04-25 date: 2024-04-25 name: Ahram Canadian University class: O... |
* The frequency of headache occurrence. |
* Visual analogue scale of chronic neck pain. Main measures: chronic neck pain will be assessed by visual analogue scale. Patients will fill out quality of life questionnaire and headache disability index. conditions: Geriatric Patients With Neck Pain studyType: OBSERVATIONAL observationalModel: COHORT timePerspective:... |
<|newrecord|> nctId: NCT06383403 id: CLIN-60190-463 id: 2024-510695-20-00 type: CTIS briefTitle: A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid. acronym: ELSPIRE overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-06-22 date: 20... |
Primary biliary cholangitis is a slowly progressive disease characterised by damage of the bile ducts in the liver, leading to a build-up of bile acids which causes further damage. The liver damage in PBC may lead to scarring (cirrhosis). PBC may also be associated with multiple symptoms. |
Many patients with PBC may require a liver transplant or may die if the disease progresses and a liver transplant is not done. This study will compare a daily dose of elafibranor (the study drug) to a daily dose of placebo (a dummy treatment). |
The main aim of this study is to determine if elafibranor is better than placebo in reducing ALP levels to a normal value. High ALP levels in the blood can indicate liver disease. |
There will be three periods in this study: A screening period (up to 8 weeks) to assess whether the participant can take part; a treatment period (up to 52 weeks) where eligible participants will be grouped as per their blood ALP levels and randomly assigned to either receive elafibranor or placebo, and a follow-up per... |
Participants will be twice as likely to receive elafibranor than placebo (2:1 ratio). |
Participants will undergo blood sampling, urine collections, physical examinations, clinical evaluations, electrocardiograms (ECG: recording of the electrical activity of heart), ultrasound examinations (a noninvasive test that passes a probe over skin to look at the bladder, urinary tract, and liver), and Fibroscan® e... |
They will also be asked to fill in questionnaires. Each participant will be in this study for up to 64 weeks (15 months). conditions: Primary Biliary Cholangitis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPAN... |
<|newrecord|> nctId: NCT06383390 id: 18584 id: J1I-MC-GZBO type: OTHER domain: Eli Lilly and Company id: 2023-508630-34-00 type: OTHER domain: EU CTR Number briefTitle: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES) overallStatus: NOT... |
<|newrecord|> nctId: NCT06383377 id: Pre-market parallel study briefTitle: Evaluation of Performance, Safety and Benefit of the Wishbone HA as Bone Graft Substitute, a Pre-market Clinical Investigation overallStatus: RECRUITING date: 2024-04-26 date: 2025-03-31 date: 2030-03-31 date: 2024-04-25 date: 2024-04-25 name: W... |
<|newrecord|> nctId: NCT06383364 id: SHS-Pharm - 1 - 2024 briefTitle: The Effect of a Medication Coordinator on the Quality of Patients Medication Treatment acronym: MEDCOOR overallStatus: ENROLLING_BY_INVITATION date: 2024-05-01 date: 2025-06-01 date: 2025-06-01 date: 2024-04-25 date: 2024-04-25 name: University of So... |
<|newrecord|> nctId: NCT06383351 id: BQ001 briefTitle: Patients' Illness Perception of Peri-implant Diseases. A Cross-sectional Study overallStatus: RECRUITING date: 2024-04-16 date: 2024-05 date: 2024-05 date: 2024-04-25 date: 2024-04-25 name: University of Siena class: OTHER briefSummary: Despite extensive research o... |
<|newrecord|> nctId: NCT06383338 id: PEGASUS briefTitle: A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma. acronym: PEGASUS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-25 date: 2024-04-25 ... |
The study involves administration of the probe medication at timepoints which align with pre-determined hospital visits for the treatment of lymphoma and subsequent blood draws to measure the metabolism of the probe medications. |
The acceptability and feasibility of this study will inform future studies in phenoconversion within the paediatric cancer population to direct more personalised precision medicine. conditions: Hodgkin Lymphoma conditions: Non Hodgkin Lymphoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interven... |
<|newrecord|> nctId: NCT06383325 id: Livertoxcicity in AL briefTitle: Livertoxcicity in Acute Leukemia Patients During Chemotherapy Treatment overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-08-01 date: 2024-04-25 date: 2024-04-25 name: Assiut University class: OTHER briefSummary: Detectio... |
<|newrecord|> nctId: NCT06383312 id: E-10840098-772.02-4248 briefTitle: Magnetic Reflexologic Insoles for Primary Dysmenorrhea overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-08 date: 2024-09 date: 2024-04-25 date: 2024-04-25 name: Istanbul Medipol University Hospital class: OTHER briefSummary: In the study,... |
<|newrecord|> nctId: NCT06383299 id: AnkaraYbuMNC briefTitle: The Validity and Reliability Study of Turkish Version of Calgary Sleep Apnea Quality of Life Index overallStatus: COMPLETED date: 2021-01-01 date: 2021-07-01 date: 2021-08-01 date: 2024-04-25 date: 2024-04-25 name: Ankara Yildirim Beyazıt University class: O... |
<|newrecord|> nctId: NCT06383286 id: AnkaraYBUfby briefTitle: The Relationship Between Physical Activity Levels and Anxiety, Depression, Stress of Disabled Athletes overallStatus: COMPLETED date: 2020-12-01 date: 2021-03-01 date: 2022-03-01 date: 2024-04-25 date: 2024-04-25 name: Ankara Yildirim Beyazıt University clas... |
<|newrecord|> nctId: NCT06383273 id: MELT-3-001 briefTitle: A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2025-01 date: 2024-04-25 date: 2024-04-25 na... |
The main questions it aims to answer are: |
1. Does MELT-300 is effective in comparison to placebo on procedural sedation for cataract surgery? |
2. To determine the effectiveness of MELT-300 compared with midazolam on procedural sedation (to determine the contribution of ketamine component and inform the risk of ketamine in MELT-300) |
3. To determine the time to achieve preoperative target sedation level with MELT-300 |
4. What medical problems do participants have when taking MELT-300 vs placebo |
Eligible participants will admitted to the study unit on Day 1. Participants will be randomized prior to surgery 4:1:1 to |
1. MELT-300 (i.e. 1 MELT-300 sublingual tablet which contains 3 mg midazolam and 50 mg of ketamine) |
2. Midazolam (i.e. 1 matching midazolam sublingual tablet which contains 3 mg midazolam) |
3. Placebo (i.e. 1 matching placebo sublingual tablet) |
Participants will receive study medication 30 (± 5) minutes, without food or water, before planned surgery start (defined as instillation of topical ocular anesthetic gel \[i.e.. 3 drops of chloroprocaine hydrochloride ophthalmic gel)\]. |
The effectiveness of MELT-300 will be performed after study medication is administered before surgery, in the course of surgery, and postoperative on Day 1 (end of surgery defined as just prior to drape removal). The safety of MELT-300 will be performed at baseline, in the course of surgery, postoperatively on Day 1, a... |
<|newrecord|> nctId: NCT06383260 id: 009-0001-7719-1189 briefTitle: Assessing the Prevalence of Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Undiagnosed Young Adults:A Cross Sectional Study overallStatus: COMPLETED date: 2023-07-01 date: 2023-09-01 date: 2023-09-01 date: 2024-04-25 date: 2024-04-25 name:... |
<|newrecord|> nctId: NCT06383247 id: AMU-PD-multicenter briefTitle: The Efficacy of Repetitive Transcranial Magnetic Stimulation With Precision Neuronavigation in Parkinson's Disease overallStatus: NOT_YET_RECRUITING date: 2024-11-01 date: 2028-12-31 date: 2030-12-31 date: 2024-04-25 date: 2024-04-29 name: Anhui Medica... |
<|newrecord|> nctId: NCT06383234 id: PAR 89/21 briefTitle: REduced Pain After Bariatric Surgery - Sleeve Gastrectomy acronym: REPABS-SG overallStatus: COMPLETED date: 2022-01-10 date: 2023-09-21 date: 2023-09-28 date: 2024-04-25 date: 2024-04-25 name: Fondazione Policlinico Universitario Campus Bio-Medico class: OTHER ... |
<|newrecord|> nctId: NCT06383221 id: 83244570 briefTitle: Study of the Intervention Effect of Stepped-care Models on Depression Symptoms During Pregnancy. overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2025-10-20 date: 2026-03-10 date: 2024-04-25 date: 2024-04-25 name: Fangbiao Tao class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06383208 id: 2024-ZF-13 briefTitle: Cardiovascular-Renal Adverse Prognosis Assessment System for Coronary Heart Disease With Chronic Kidney Disease Based on Metabolomics acronym: CRUISE-MET overallStatus: RECRUITING date: 2024-04-01 date: 2027-03-31 date: 2027-03-31 date: 2024-04-25 date: 2024-0... |
Furthermore, the emerging concept of "cardiovascular-kidney-metabolic syndrome" and the availability of new treatment options highlight the urgent need for a risk stratification tool tailored to modern management strategies and treatment goals to guide preventive measures effectively. To address this, we propose to con... |
<|newrecord|> nctId: NCT06383195 id: SBA 24/189 briefTitle: The Reliability and Validity of the Ankylosing Spondylitis Performance Index (ASPI) in Enthesitis-Related Arthritis overallStatus: RECRUITING date: 2024-03-21 date: 2026-03-20 date: 2026-03-20 date: 2024-04-25 date: 2024-04-25 name: Hacettepe University class:... |
<|newrecord|> nctId: NCT06383182 id: Y (2024) 054 briefTitle: Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion overallStatus: NOT_YET_RECRUITING date: 2024-05-07 date: 2026-12-30 date: 2026-12-30 date: 2024-04-25 date: 2024-04-25 name: General Hospital of She... |
<|newrecord|> nctId: NCT06383169 id: wanglizhong briefTitle: Impact of External Drainage of the Lumbar Cistern in Patients With Hydrocephalus Following Meningioma Surgery and Its Influence on Patient Satisfaction overallStatus: COMPLETED date: 2019-05-01 date: 2022-05-01 date: 2022-05-30 date: 2024-04-25 date: 2024-04-... |
<|newrecord|> nctId: NCT06383156 id: MD157/2023 briefTitle: The Use of Lung US, Fluoroscopy and Auscultation to Confirm Proper Positioning of Left Sided DLT : A Comparative Study overallStatus: NOT_YET_RECRUITING date: 2024-04-17 date: 2024-09-18 date: 2024-10-01 date: 2024-04-25 date: 2024-04-25 name: Ain Shams Univer... |
<|newrecord|> nctId: NCT06383143 id: AC-020-IT briefTitle: Promoting Diagnosis and Management of AL in Italy (ProDigALIty) acronym: ProDigALIty overallStatus: RECRUITING date: 2023-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-04-25 date: 2024-04-25 name: IRCCS Policlinico S. Matteo class: OTHER briefSummary: We p... |
1. Implement a biomarker-based screening strategy to promote early diagnosis of AL amyloidosis among at-risk patients, including patients with monoclonal gammopathy of undetermined significance, MGUS, and altered free light chain ratio (aFLCR), and patients with smoldering multiple myeloma (SMM) |
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