Spice and Wolf (狼と香辛料, Ōkami to Kōshinryō) is a Japanese light novel series written by Isuna Hasekura, with illustrations by Jū Ayakura. ASCII Media Works has published 24 novels since February 2006 under their Dengeki Bunko imprint. ASCII Media Works reported that as of October 2008, over 2.2 million copies of the first nine novels have been sold in Japan. The series has been called a "unique fantasy" by Mainichi Shimbun due to the plot focusing on economics, trade, and peddling rather than the typical staples of fantasy such as swords and magic. Yen Press licensed the light novels and is releasing them in English in North America. ASCII Media Works has published five volumes of a spin-off light novel series titled Wolf and Parchment since September 2016.
 A manga adaptation illustrated by Keito Koume began serialization in the November 2007 issue of ASCII Media Works' seinen manga magazine Dengeki Maoh. The manga was licensed by Yen Press, which has begun releasing the volumes in English. A 12-episode anime adaptation aired between January and March 2008, plus a single original video animation (OVA) episode released in May 2008. A second OVA was released in April 2009 as a prequel to the second anime season Spice and Wolf II, which aired 12 episodes between July and September 2009. Both anime seasons were released in English by Kadokawa Pictures USA and Funimation. Two visual novels based on the series for the Nintendo DS were released by ASCII Media Works in June 2008 and September 2009. A new anime television series adaptation is set to premiere in 2024.
 Spice and Wolf's story revolves around Kraft Lawrence, a 25-year-old traveling merchant who peddles various goods from town to town to make a living in a stylized, fictional world, with a  historical setting with European influences. His main goal in life is to gather enough money to start his own shop, and he already has been traveling for seven years while gaining experience in the trade. One night when stopped at the town of Pasloe, he finds in his wagon a wolf-deity named Holo who is over 600 years old. She takes the form of a 15-year-old girl, except for a wolf's tail and ears. She introduces herself as the town's goddess of harvest, who has kept it blessed with good harvests of wheat for many years. Holo has experienced increasing isolation and disillusionment at the townpeople's move away from her protection towards their own methods of increasing the harvest.  She is especially hurt at their forgetting of the promise made between her and a farmer when she arrived in the village and their criticism of her as a "fickle god" for needing to replenish the soil with smaller harvests.  Because of these changes, she wants to go back to her homeland in the north called Yoitsu; she believes the people have already forsaken her and that she has kept her promise to maintain the good harvests. Holo also wants to travel to see how the world has changed while she has remained in one place for many years. She manages to bargain her way out of the village by making a deal with Lawrence to take her with him. As they travel, her wisdom helps increase his profits, but at the same time, her true nature draws unwanted attention from the Church.
 Spice and Wolf began as a light novel series written by Isuna Hasekura, with illustrations by Jū Ayakura. Originally, Hasekura entered the first novel in the series into ASCII Media Works' twelfth Dengeki Novel Prize in 2005 and the novel won the Silver Prize. ASCII Media Works published 17 novels between February 10, 2006 and July 10, 2011 under their Dengeki Bunko imprint. The tagline for the novels is "Merchant meats spicy wolf.", an example of Engrish. The author of the novels has commented that what "meats" in the tagline really means is kept a secret, alluding to a possible intentional misspelling of "meets". In celebration of the series' 10th anniversary, Hasekura began writing a sequel in the 49th volume of Dengeki Bunko Magazine, released on April 9, 2016. In 2016, publication of new books in the series resumed with the release of the eighteenth volume, along with the start of a spin-off series titled Wolf and Parchment: New Theory Spice & Wolf, focusing on the characters Cole and Myuri, Lawrence and Holo's daughter.
 In September 2008, the novels were licensed by Yen Press for distribution in English. The first volume was released in December 2009, and a new volume was released every four months. While Yen Press redesigned the cover of the first novel, a dust jacket retaining the original cover art was released to select online retailers, and Yen Press also bundled the same jacket in the December 2009 issue of their manga anthology magazine Yen Plus. Despite the different cover art, the illustrations within the novels remain unchanged. Yen Press later announced that future volumes of the series and reprints of the first volume would retain the original artwork while dust jackets would carry the new covers, citing that the redesigned covers were requested by retailers in order to appeal to a wider audience. Yen Press has also licensed the Wolf and Parchment series, with the first volume released in November 2017.
 A manga adaptation illustrated by Keito Koume began serialization in the November 2007 issue of ASCII Media Works' seinen manga magazine Dengeki Maoh. The first tankōbon volume was released by ASCII Media Works under their Dengeki Comics imprint on March 27, 2008; 16 volumes have been published as of February 2018. Yen Press licensed the manga series at New York Comic Con 2009, and began releasing the series in English in North America.
 A manga adaption of Wolf and Parchment by Hidori began serialization in the July 2019 issue of Dengeki Maoh.
 An Internet radio show hosted by Animate called Ōkamikku Radio (オオカミックラジオ) aired ten episodes between December 7, 2007 and April 25, 2008. One episode was broadcast every other week on Friday, and the show was meant to mainly promote the anime series. The show is hosted by Jun Fukuyama who plays Kraft Lawrence in the anime, and Ami Koshimizu who plays Holo. The show contains eight corners, or parts to each broadcast which includes news about the series, comments and submissions from listeners, and a radio drama. A second radio show titled Ōkamikku Radio II aired ten episodes between June 10 and October 28, 2009 with the same producer and hosts.
 An anime adaptation produced by the animation studio Imagin aired in Japan between January 9 and March 26, 2008 on the Chiba TV Japanese television network; twelve of the thirteen episodes were broadcast, with episode seven being a DVD exclusive. The episodes are being released in six DVD compilation volumes in Japan; volume one contains three episodes while the subsequent volumes contain two episodes each. The volumes were released between April 2, 2008 and August 29, 2008 by Pony Canyon in Japan; volume three contains an original video animation (OVA) episode in addition to episode six of the television broadcast. A Blu-ray Disc box set of the series was released on January 30, 2009. The series is directed by Takeo Takahashi, written by Naruhisa Arakawa, and character designs are provided by Kazuya Kuroda. Takahashi was quoted as being a big fan of the novels. The opening theme is "Tabi no Tochū" (旅の途中) by Natsumi Kiyoura, and the ending theme is "Ringo Biyori: The Wolf Whistling Song" (リンゴ日和 ～The Wolf Whistling Song) by Rocky Chack; both maxi singles were released on February 6, 2008. The anime's original soundtrack was released on March 12, 2008. The anime is licensed for release in English by Kadokawa Pictures USA and Funimation Entertainment, and a complete thirteen-episode DVD box set was released on December 22, 2009. The series made its North American television debut on November 16, 2010 on the Funimation Channel.
 A second season of the anime titled Spice and Wolf II aired twelve episodes in Japan between July 9 and September 24, 2009. Most of the staff from the first season returned, except for Toshimitsu Kobayashi replacing Kazuya Kuroda as the character designer and chief animation director, and Spice and Wolf II is animated by Brain's Base and Marvy Jack instead of Imagin. The voice actors from the first season retained their roles. Another OVA, animated by Brain's Base and Marvy Jack, was released bundled with a picture book entitled Spice and Wolf: Wolf and Gold Wheat (「狼と香辛料」狼と金の麦穂, Ōkami to Kōshinryō Ōkami to Kin no Mugiho) written and illustrated by the same creators of the light novels and was released by ASCII Media Works on April 30, 2009 under their Dengeki Bunko Visual Novel imprint. Funimation licensed Spice and Wolf II and released the series in English on August 30, 2011. The second season made its North American television debut on August 31, 2011 on the Funimation Channel. On September 11, 2012, Funimation released a Blu-ray/DVD combo pack of both seasons. The April 30, 2009 OVA is included on the season two disc as episode 00. 
 A new anime adaptation was announced on February 25, 2022, as part of the novel's 15-year anniversary. It was later confirmed to be a television series, titled Spice and Wolf: Merchant Meets the Wise Wolf, produced by Passione and directed by Hijiri Sanpei, with Takahashi returning as chief director, Kevin Penkin composing the music, and Fukuyama and Koshimizu returning to reprise their roles as Lawrence and Holo respectively. The series is set to premiere in 2024. Crunchyroll licensed the series.
 A dating and business simulation visual novel based on the series, Spice and Wolf: Holo's and My One Year, was developed by ASCII Media Works for the Nintendo DS, and was released on June 26, 2008 in Japan. It never had an official Western release, but received a fan translation into English by AGT Team on February 20, 2021 under the localized title Spice and Wolf: My Year With Holo. The player assumes the role of a nameless character (the titular "Boku", who closely resembles Kraft Lawrence). In exchange for cheaply obtaining Holo's wagon, he promises to help her find her hometown before the year's end by using his merchant skills to purchase information. In the meantime, the player raises their intimacy with her via story-based event scenes, potentially resulting in different endings. The story differs from that of the original novels or anime, and is presented as an alternate universe. Ami Koshimizu provides the voice of Holo in the game. The game was released on the same day in limited and regular editions; the limited edition was sold at a higher price, but comes with a life-sized poster of Holo, among other things.
 A sequel, also by ASCII Media Works for Nintendo DS, was released on September 17, 2009 in Japan, titled Spice and Wolf: The Wind that Spans the Sea. The player once again assumes the role of Kraft Lawrence. A fan translation of the game into English has been done by the AGT Team.
 A virtual reality adventure game titled Spice and Wolf VR and made by Spicy Tails, a dōjin group founded by Isuna Hasekura, was released on June 3, 2019 for Microsoft Windows supporting the Oculus Rift and HTC Vive VR headsets as well as the standalone Oculus Go headset. It was later released for the Nintendo Switch and PlayStation 4 on September 5, 2019, supporting the Nintendo Labo VR Kit and PlayStation VR respectively. A port to the Oculus Quest headset was released in November 2019. Its sequel, Spice and Wolf VR2, was released on December 10, 2020.
 ASCII Media Works reported that as of November 2009, over 3.5 million copies of the first twelve novels have been sold. The light novel series has ranked three times in Takarajimasha's light novel guide book Kono Light Novel ga Sugoi! published yearly: first in 2007, and fifth in both 2008 and 2009; in the 2007 issue, Holo won Best Female Character. The first manga volume of the English release in North America debuted at No. 4 on the New York Times Best Seller Manga list, while the third volume reached at No. 3.
 In April 2008, the maid café Cafe with Cat in Akihabara, Tokyo, Japan hosted a specially themed event called Cafe with Wolf for a period of three days between April 4 and April 6. The event included three new items on the menu and tied in with the sale of the first anime DVD volume which went on sale on April 2, 2008. People who bought the DVD from the Comic Toranoana Akihabara Honten store (which is on the first floor below Cafe with Cat) and brought the receipt with them into Cafe with Wolf were entered into a lottery to win rare Spice and Wolf goods.