The 2020 Iowa State Cyclones football team represented Iowa State University in the 2020 NCAA Division I FBS football season. The Cyclones competed as members of the Big 12 Conference and were led by fifth-year head coach Matt Campbell. They played their home games at Jack Trice Stadium in Ames, Iowa. Breece Hall became the first unanimous all-American in school history.
After starting the season with a loss to Louisiana, Iowa State won eight out of nine Big 12 Conference games, finishing the season with the best record in the Big 12 and earning a spot in the program's first ever Big 12 Championship Game. Despite falling to Oklahoma, Iowa State was given a bid to the Fiesta Bowl, the Cyclones first ever appearance in a New Year's Six Bowl Game, where they defeated the Oregon Ducks, and due to the COVID 19 shortened season, became one of only eleven teams in the nation to have at least nine wins.
 On May 26, 2020, Iowa State athletic director Jamie Pollard announced that single-game tickets would not be sold for Iowa State football games for the 2020 season and that only the 30,000 season ticket holders would be permitted to attend games, as a result of the COVID-19 pandemic.
 The Big 12 media days were held on July 21–22, 2020 in a virtual format due to the COVID-19 pandemic.
 The Cyclones announced they would cancel spring practice in March and April 2020 and would not hold a spring game.
 Spring practices were cancelled due to the COVID-19 pandemic.
 Iowa State released its 2020 schedule on October 22, 2019. On July 9, 2020, it was announced that the Big Ten Conference would only play games against conference teams, leading to the cancellation of the September 12 game between Iowa State and Iowa. The Cyclones added Ball State to the schedule to replace in-state rival Iowa. On August 6, 2020, Iowa State's game against UNLV was canceled and rescheduled for the 2030 season. The Cyclones announced a reconfigured schedule on August 12, 2020, with the addition of Louisiana as their non-conference opponent. On December 5, after Oklahoma State and Kansas State lost their respective games, Iowa State officially clinched a spot in their very first Big 12 Championship Game.
 Quarterback
 Running back
 Wide receiver
 Placekicker
 Tight end
 Offensive Lineman 
 Defensive Lineman
 Linebacker
 Defensive back
 Long snappers
 Punter
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 at Jack Trice Stadium • Ames, IA
 at Amon G. Carter Stadium • Fort Worth, TX
 at Jack Trice Stadium • Ames, IA
 at Jack Trice Stadium • Ames, IA
 at Boone Pickens Stadium • Stillwater, OK
 at David Booth Kansas Memorial Stadium • Lawrence, KS
 at Jack Trice Stadium • Ames, IA
 at Jack Trice Stadium • Ames, IA
 at Darrell K Royal–Texas Memorial Stadium • Austin, TX
 at Jack Trice Stadium • Ames, IA
 at AT&T Stadium • Arlington, TX
 at State Farm Stadium • Glendale, AZ
 Iowa State led all Big 12 schools with nine All-Big 12 first team players.
 Hall was a unanimous selection.
 Honorable Mention for Individual Big 12 Awards: JaQuan Bailey (Defensive Lineman of the Year), Latrell Bankston (Defensive Newcomer of the Year), Colin  Newell (Offensive Lineman of the Year), Darrell Simmons (Offensive Freshman of the Year) and Rory Walling (Special Teams Player of the Year).
 All totals via Sports Media Watch. Streaming numbers not included. † - Data not available.