Pennsylvania Route 208 Pennsylvania Route 208 (PA 208) is located in Western Pennsylvania; its western terminus just west of the village of New Bedford in Lawrence County (11.5 miles northwest of New Castle) at U.S. Route 422 (US 422) and the Ohio state line.  It runs nearly 75 miles (121 km) to its eastern terminus in the village of Frills Corners in Clarion County (22 miles east of Oil City) at PA 36.
 The route begins in Lawrence County where US 422 meets the Ohio state line; PA 208 heads east-northeastward to the village of New Bedford about a mile from the state line.  The route junctions with the former PA 932 in the village and was the former alignment of US 422 from the state line to this point, where the old alignment turned southeast; PA 208 continues eastward here.  About 3.5 miles (5.6 km) later, it is joined by PA 551 and the concurrency turns northward for about 0.5 miles (0.80 km) before turning east again as it crosses the Shenango River and enters the village of Pulaski.  The concurrency ends 0.3 miles (0.48 km) later, and PA 208 continues another 0.3 miles (0.48 km) to its interchange with Interstate 376 (I-376). From here, the route heads into a rural area of northern Lawrence County that is home to an Amish community. The road continues another 3.6 miles (5.8 km) east, where it junctions with PA 18 about 1.4 miles (2.3 km) west of the borough of New Wilmington, which the route enters shortly thereafter.  In the borough, PA 158 joins briefly, and then leaves the route at the northern terminus of PA 956.  PA 208 passes north of Westminster College before it leaves the borough and continues eastward about 3 miles (4.8 km) to the borough of Volant, where, at the east end of the borough, the route intersects with the northern terminus of PA 168 and turns northeast and crosses the county line 0.7 miles (1.1 km) later.
 As PA 208 enters Mercer County, it turns east-northeast and meets US 19 at the village of Leesburg about 1.7 miles (2.7 km) later.  The routes briefly overlap northward, and then PA 208 continues east-northeastward.  About 3.5 miles (5.6 km) from Leesburg, the route is joined by PA 258 north of the Grove City Premium Outlets, and the concurrency then interchanges with I-79 (exit 113) immediately thereafter.  The concurrency ends 0.4 miles (0.64 km) later at the village of London – prior to the interstate, this was a simple junction between PA 208 and PA 258.  PA 208 continues east-northeast about 3.5 miles (5.6 km) to the borough of Grove City, where it meets PA 58 and PA 173.  This point is the westernt terminus of the PA 58/PA 173 concurrency, and the southern terminus of the PA 173/PA 208 concurrency; also at this point, the north- and southbound lanes of the PA 173/PA 208 concurrency are split on one-way streets through the downtown area of Grove City, heading northward for about 0.4 miles (0.64 km).  Another 0.4 miles (0.64 km) later, the concurrency ends, and PA 208 continues eastward, leaves the borough, and meets the county line 4.5 miles (7.2 km) later.
 PA 208 enters Venango County, and 1.3 miles (2.1 km) later intersects with PA 8 in the borough of Barkeyville.  The route continues eastward 3.1 miles (5.0 km) where it passes over I-80 before entering the borough of Clintonville 1.5 miles (2.4 km) later; here the route intersects with PA 308.  About 7.6 miles (12.2 km) later, or 1.8 miles (2.9 km) west of the borough of Emlenton, the route is joined by PA 38; this route, just south of this intersection, meets I-80 (exit 42).  The concurrency meets the northern terminus of PA 268 about 1.6 miles (2.6 km) later in the borough, and turns north to cross the Allegheny River.  The concurrency turns east at the center of the town, then crosses into Clarion County 0.5 miles (0.80 km) later, winding northward, eastward, and finally east-northeastward, crossing back into Venango County again 1.3 miles (2.1 km) later.  The concurrency meets the northern terminus of PA 478 0.3 miles (0.48 km) later; just south of this intersection, PA 478 has a partial interchange with I-80 (exit 45) for traffic exiting or entering eastbound.  The westbound interchange ramps are 0.3 eastward on the PA 38/PA 208 concurrency, which continues northeasterly to the county line 0.3 miles (0.48 km) later.
 After crossing into Clarion County a second and final time, the PA 38/PA 208 concurrency continues north-northeastward 1.2 miles (1.9 km) before its northern terminus.  PA 208 turns eastward and winds 7.3 miles (11.7 km) to the borough of Knox, where the route turns south and then east again, intersecting with PA 338 about 0.5 miles (0.80 km) from the center of the borough.  Continuing east-northeast, the route travels 3.8 miles (6.1 km) to the borough of Shippenville, where it meets US 322.  The two routes overlap for 0.2 miles (0.32 km) eastward, where PA 208 turns north, traveling 7.6 miles (12.2 km) to the village of Fryburg.  Here, the route intersects with the eastern terminus of PA 157, and PA 208 turns northeastward for about 4 miles (6.4 km), then turns north again, where it terminates about 1-mile (1.6 km) later in the village of Frills Corners at PA 36.
   Pennsylvania Route 208 Truck Pennsylvania Route 208 Truck was a truck route around a weight-restricted bridge over the Doe Creek on which trucks over 20 tons and combination loads over 26 tons were prohibited.  The route followed US 422 and PA 551.  The route was signed in 2013. All weight restricted bridges on the stretch of PA 208 were rebuilt in 2017 and 2018, resulting in the deletion of the route.