Cruciform is a term for physical manifestations resembling a common cross or Christian cross. The label can be extended to architectural shapes, biology, art, and design.
 Christian churches are commonly described as having a cruciform architecture. In Early Christian, Byzantine and other Eastern Orthodox forms of church architecture this is likely to mean a tetraconch plan, a Greek cross, with arms of equal length or, later, a cross-in-square plan.
 In the Western churches, a cruciform architecture usually, though not exclusively, means a church built with the layout developed in Gothic architecture. This layout comprises the following:
 In churches that are not oriented with the altar at the geographical east end, it is usual to refer to the altar end as "liturgical east" and so forth.
 Methodist tabernacles also have a cruciform shape.
 Another example of ancient cruciform architecture can be found in Herod's temple, the second Jewish temple.
 DNA can undergo transitions to form a cruciform shape, including a structure called a Holliday junction. This structure is important for the critical biological processes of DNA recombination and repair mutations that occur in the cell.
 A cruciform joint is a specific joint in which four spaces are created by the welding of three plates of metal at right angles.
 A cruciform manuscript was a form of Anglo-Saxon / Insular manuscript written with the words in a block shaped like a cross.
 In music, a melody of four pitches where a straight line drawn between the outer pair bisects a straight line drawn between the inner pair, thus forming a cross. In its simplest form, the cruciform melody is a changing tone, where the melody ascends or descends by step, skips below or above the first pitch, then returns to the first pitch by step. Often representative of the Christian cross, such melodies are cruciform in their retrogrades or inversions. Johann Sebastian Bach, whose last name may be represented in tones through a musical cryptogram known as the BACH motif that is a cruciform melody, employed the device extensively. The subject of the fugue in c-sharp minor from The Well-Tempered Clavier Book I is cruciform. See also: Cross motif.
 Some airplanes use a cruciform tail design, wherein the horizontal stabilizer is positioned midway up the vertical stabilizer, forming a cruciform shape when viewed from the front or rear. Some examples are the F-9 Cougar, the F-10 Skyknight and the Sud Aviation Caravelle.
 The cruciform tail gives the benefit of clearing the aerodynamics of the tail away from the wake of the engine, while not requiring the same amount of strengthening of the vertical tail section in comparison with a T-tail design.
 The plain sword used by knights, distinctive due to the flat bar used as a guard. The overall shape of the sword when held point down is that of a cross.
 It is believed this shape was encouraged by the church to remind Knights of their religion.[citation needed] It was however very popular due to the protection it offered to the hand and certain attacks that rely on the cross to trap the blade of the enemy. See Sword.
 Cruciform web designs use a cross-shaped web page that expands to fill the width and height of the web browser window. There are a number of different approaches to implementing them.
 In addition to common cross-shaped products, such as key chains and magnets, certain designers have gone so far as to create cruciform devices and accessories. For example, the mass-produced cruciform MP3 player "Saint B", or the "iBelieve", an accessory that converts the original iPod Shuffle into a cross shape designed by Scott Wilson in 2005. The cruciform MP3 players often come preloaded with audio files of the New Testament, but are mainly purchased for users to proudly display their faith.