The Treaty of Moultrie Creek, also known as the Treaty with the Florida Tribes of Indians, was an agreement signed in 1823 between the government of the United States and the chiefs of several groups and bands of Indians living in the present-day state of Florida. The treaty established a reservation in the center of the Florida peninsula. It also ceded all coastal lands to the United States Government, as the U.S. wanted control of overseas trade between the Florida and the Caribbean. 
 The indigenous peoples of Florida had largely died out by early in the 18th century. Various groups and bands of Muskogean-speakers (called Creek Indians by the British), Yamasees and Yuchis moved into the area, often with the encouragement of the Spanish colonial government. These groups, which often lived on both sides of the border between Florida and Georgia, came into increasing conflict with white settlers after the United States became independent. When the United States acquired Florida from Spain in 1821 (by means of the Adams-Onís Treaty), the conflict increased. In 1823, the United States government decided to settle the Seminoles on a reservation in the central part of the territory.
 A meeting to negotiate a treaty was scheduled for early September 1823 at Moultrie Creek, south of St. Augustine. About 425 Seminoles attended the meeting, choosing Neamathla, a prominent Mikasuki chief, to be their chief representative. Under the terms of the treaty negotiated there, the Seminoles were forced to place themselves under the protection of the United States and to give up all claim to lands in Florida, in exchange for a reservation of about four million acres (16,000 km²).
 The reservation ran down the middle of the Florida peninsula from just north of present-day Ocala to a line even with the southern end of Tampa Bay. The boundaries were well inland from both coasts, to prevent contact with traders from Cuba and the Bahamas. Neamathla and five other chiefs, however, were allowed to keep their villages along the Apalachicola River.
 Under the Treaty of Moultrie Creek, the United States government was obligated to protect the Seminoles as long as they remained peaceful and law-abiding. The government was supposed to distribute US$6000 worth of farm implements, cattle and hogs to the Seminoles, compensate them for travel and losses involved in relocating to the reservation, and provide rations for a year, until the Seminoles could plant and harvest new crops. The government was also supposed to pay the tribe US$5,000 a year for twenty years, and provide an interpreter, a school and a blacksmith for the same twenty years. No white person was allowed to settle, farm, or hunt the reservation land as well. In turn, the Seminoles had to allow roads to be built across the reservation and had to apprehend any runaway slaves or other fugitives and return them to United States jurisdiction.[further explanation needed]
 In the first nine years, the money promised was slow in arriving and promised sums were not met. Murders and conflicts between Natives and white settlers within the allocated territory also went unpunished, violating the Article 4 of the Treaty. When the Treaty of Payne's Landing was introduced nine years after the Treaty with the Florida Indian Tribes, the 4 million dollars of central land given to the tribes was taken and the U.S. government forced the Indians to be relocated to the Western Territories in Oklahoma . This ultimately ended the Treaty of 1823, and began the Second Seminole War.