The following is a list of the FedEx Air & Ground NFL Players of the Week award, sponsored by transportation and delivery company FedEx. Since 2003, following each week of the NFL regular season, six finalists are chosen, based on exemplary individual statistical performances. Three players are nominated for the "Air" award (quarterbacks) and three are nominated for the "Ground" award (running backs), but only one player from each category will take the title. The weekly winners are voted on by fans via an online poll at NFL.com. The "Air" and "Ground" categories are duly named and inspired by FedEx's cargo airline and ground transportation services, FedEx Express and FedEx Ground, respectively.
 At the conclusion of the season, three overall finalists are selected for the "Air" and "Ground" players of the year. Once again, fans vote online for the winners of each category.
 -Tomlinson broke the single-season touchdown record in this game
 -First player to be named FedEx Ground POTW 8 times in a single season
 -This was the final regular season game of Barber's career.
 -Joined Drew Brees as only players to throw for 300+ yds 100 or more times
 -Brady improved to 9–0 in career vs Falcons
 -First FedEx Ground POTW award for Elliott since 2016
 -11th career 300-yard game: most by any quarterback in their first two years in the league
 -14 career rushing touchdowns vs Jaguars: most by any Titans/Oilers player
 -Fourth straight game with 3+ touchdowns; first victory by Dallas in New England since 1987
 -416 yards set a new career high
 -First career start
 -First player to throw for 400+ yards in first career start since Cam Newton in 2011
 -First Jet to be named FedEx Air POTW since Brett Favre in 2008
 -Fifth quarterback in NFL history to have 300+ yards passing and 90+ yards rushing in the same game
 -Third consecutive game with 2 rushing touchdowns
 -10th consecutive game with a rushing touchdown: most since LaDainian Tomlinson in 2004-05
 -First player to throw 30+ touchdown passes in his first two seasons
 -Second career 200-yard game
 -First Lion to be named FedEx Air POTW since Matthew Stafford in 2011
 -17th rushing touchdown of the season set a new franchise record
 -First career 500-yard game: 525 yards also set a new franchise record
 -Set a new career-high in rushing yards: first Texan to win FedEx Ground POTW since Arian Foster in 2012
 -Set the new single-season franchise record for touchdowns and passing yards
 -Joined Drew Brees as only players in NFL history with multiple 5,000 yard seasons
 -190 yards set a new career-high
 -Mahomes moved to 5–0 in season openers for his career
 -First career 400-yard game; 6 touchdowns tied franchise record
 -Set a new career-high in rushing yards
 -Set a new career-high for passing yards
 -Set a new career-high for rushing yards: joins Lamar Jackson as only non-running backs to be named FedEx Ground POTW
 -First career start, set a new career-high in rushing yards: first player born in 2000s to be named FedEx Ground POTW
 -First quarterback with five games of 400+ passing yards in his first three seasons
 -First career game with multiple rushing touchdowns
 -Tied career-high in rushing yards; first Cowboys RB with a three touchdown game since Joseph Randle in 2015
 -First player with 150+ yards and 4+ touchdowns from scrimmage in the first half of a game since Shaun Alexander in 2002
 -Third straight game with three passing touchdowns; first player to win three consecutive FedEx Air POTW awards since Aaron Rodgers in 2011
 -First quarterback in the Super Bowl era with multiple 60+ yard rushing touchdowns in the same season; becomes only the third non-running back to be named FedEx Ground POTW
 -Set a new single-game career high for rushing touchdowns; first Lions player to rush for 3+ touchdowns in one game since Mikel Leshoure in 2012
 -2nd career game with 300+ passing yards and 3+ passing touchdowns in his 4th career start
 -Set a new franchise record for rushing yards in a single game; two touchdowns included a game-winning touchdown in overtime
 -3rd career game with 300+ passing yards and 3+ passing touchdowns
 -9th career game with 100+ rushing yards and 1+ rushing touchdowns
 -Vikings' 33-point come-from-behind victory over the Colts set the record for the largest comeback in NFL history
 -Set a new career-high in rushing yards; first Patriots player to be named FedEx Ground POTW since LeGarrette Blount in 2013
 -Set a new single-game career high for rushing touchdowns; first Rams player to be named FedEx Ground POTW since C.J. Anderson in 2018
 -With Buccaneers' victory, Brady clinched a playoff berth for the 14th consecutive season
 -Set a new career-high in rushing yards
 -Third consecutive game with 100+ rushing yards
 -Named NFL co-Most Valuable Player with Steve McNair
 -Named to his third career Pro Bowl
 -Named NFL Most Valuable Player for second straight year, named NFL OPOY
 -Named to his fifth career Pro Bowl
 -Named to his first career Pro Bowl
 -Named NFL Most Valuable Player and NFL OPOY for the first time in his career
 -Named to his second career Pro Bowl
 -Named NFL Most Valuable Player and NFL OPOY for the first time in his career
 -Named to his ninth career Pro Bowl in his final season in Green Bay
 -Named to his first career Pro Bowl
 -Named NFL OPOY
 -Named to his second career Pro Bowl
 -Won Super Bowl XLIV
 -Named NFL OPOY for the first time in his career
 -Won Super Bowl XLV
 -Named to his first career Pro Bowl
 -Named NFL OPOY
 -Named to his first career Pro Bowl
 -Named NFL Comeback Player of the Year in first full season since undergoing neck surgery
 -Named NFL Most Valuable Player and NFL OPOY for the first time in his career; finished with the second-most rushing yards by a running back in a single season
 -Named NFL Most Valuable Player for a record fifth time in his career, named NFL OPOY
 -Named to his second career Pro Bowl
 -Named NFL Most Valuable Player for the second time in his career
 -Named to his first career Pro Bowl
 -Named to his third career Pro Bowl, his first in nine seasons
 -Named to his seventh career Pro Bowl; first player to win the rushing title three times since Barry Sanders
 -Named NFL Most Valuable Player and NFL OPOY for the first time in his career
 -Named to his first career Pro Bowl
 -Named to first career Pro Bowl, won Super Bowl LII (but did not play due to injury)
 -Named NFL OPOY for the first time in his career
 -Named NFL Most Valuable Player and NFL OPOY for the first time in his career
 -Named the 2018 NFL Offensive Rookie of the Year
 -Named NFL Most Valuable Player; second player ever to be voted MVP unanimously
 -Named to his first career Pro Bowl
 -Named NFL Most Valuable Player for the third time in his career
 -Named NFL OPOY for the first time in his career
 -Named to his 15th career Pro Bowl
 -Named to his first career Pro Bowl
 -Named to his first career Pro Bowl
 -Named to his second career Pro Bowl; joined Marcus Allen as the only Raiders players to lead the league in rushing