This is a list of the mammal species recorded in Colombia. Of the mammals in Colombia, four are critically endangered, eight are endangered, twenty-seven are vulnerable, and six are near threatened. One of the species listed for Colombia is considered to be extinct.
 The following tags are used to highlight each species' conservation status as assessed by the International Union for Conservation of Nature:
 Some species were assessed using an earlier set of criteria. Species assessed using this system have the following instead of near threatened and least concern categories:
 Didelphimorphia is the order of common opossums of the Western Hemisphere. Opossums probably diverged from the basic South American marsupials in the late Cretaceous or early Paleocene. They are small to medium-sized marsupials, about the size of a large house cat, with a long snout and prehensile tail.
 There are six extant species of shrew opossum. They are small shrew-like marsupials confined to the Andes.
 Sirenia is an order of fully aquatic, herbivorous mammals that inhabit rivers, estuaries, coastal marine waters, swamps, and marine wetlands. All four species are endangered.
 The armadillos are small mammals with a bony armored shell. They are native to the Americas. There are around 20 extant species.
 The order Pilosa is extant only in the Americas and includes the anteaters, sloths, and tamanduas.
 The order Primates contains humans and their closest relatives: lemurs, lorisoids, monkeys, and apes.
 Rodents make up the largest order of mammals, with over 40% of mammalian species. They have two incisors in the upper and lower jaw which grow continually and must be kept short by gnawing. Most rodents are small though the capybara can weigh up to 45 kg (99 lb).
 The lagomorphs comprise two families, Leporidae (hares and rabbits), and Ochotonidae (pikas). Though they can resemble rodents, and were classified as a superfamily in that order until the early 20th century, they have since been considered a separate order. They differ from rodents in a number of physical characteristics, such as having four incisors in the upper jaw rather than two.
 Eulipotyphlans are insectivorous mammals. Shrews and solenodons closely resemble mice, hedgehogs carry spines, while moles are stout-bodied burrowers.
 The bats' most distinguishing feature is that their forelimbs are developed as wings, making them the only mammals capable of flight. Bat species account for about 20% of all mammals.
 The order Cetacea includes whales, dolphins and porpoises. They are the mammals most fully adapted to aquatic life with a spindle-shaped nearly hairless body, protected by a thick layer of blubber, and forelimbs and tail modified to provide propulsion underwater.
 There are over 260 species of carnivores, the majority of which eat meat as their primary dietary item. They have a characteristic skull shape and dentition.
 The odd-toed ungulates are browsing and grazing mammals. They are usually large to very large, and have relatively simple stomachs and a large middle toe.
 The even-toed ungulates are ungulates whose weight is borne about equally by the third and fourth toes, rather than mostly or entirely by the third as in perissodactyls. There are about 220 artiodactyl species, including many that are of great economic importance to humans.