This article provides a list of characters from the American television sitcom Drake & Josh along with brief synopsis of the time each of them spent on the show. Airing on Nickelodeon from January 11, 2004, to September 16, 2007, Drake & Josh was created by Dan Schneider, who also served as executive producer.
 Drake Parker (Drake Bell) is Josh's stepbrother, Megan's older biological brother, Audrey's biological son and Walter's stepson. Drake is depicted as an immature womanizing teenage slacker. Although he often appears unintelligent, his under-achievement seems to be caused by apathy, which leads him to make frequent impulsive decisions. The character Drake has a great interest in music and plays electric guitar in a band. He likes all genres of music including rock and country. He can also play drums and bongos. He can easily manipulate Josh in order to get what he wants. He has a lot of success with girls, and much of the comedy is his effortless ability to get dates. He often shrugs off the consequences of his actions, acts bitter towards others, plays dirty, lacks respect for them, slacks off at school, and uses other people, which can get him into trouble. Drake feels embarrassed about his new stepbrother at first but grew to accept Josh. Despite his desire to not spend time with Josh, Drake and Josh eventually become close friends and brothers. His character is similar to that of Jesse Katsopolis from Full House and Eric Matthews from Boy Meets World.
 Josh Nichols (Josh Peck) is Drake and Megan's stepbrother, Walter's biological son and Audrey's stepson. Unlike Drake, Josh is knowledgeable, diligent, caring, responsible, a good hard-working student and socially awkward. In the pilot episode, he had a job for the school newspaper in which he wrote advice for students under the name Miss Nancy. He begins working for Helen at the fictional Premiere movie theatre in the second season. Unlike Drake, Josh often tries his best in challenging situations, takes things seriously, feels resourceful if he makes mistakes, and uses his common sense, often repeating things for emphasis when anxious. Despite his logical mind and hard-working nature, Josh is prone to bad luck in the first seasons, especially with girls. However, later in the series he begins to date Mindy Crenshaw, his academic rival. His hobbies include cooking and performing magic tricks. Later in the series, Josh becomes popular and has better luck as he loses weight. He is obsessed with Oprah Winfrey and accidentally runs her over with his car in "Josh Runs into Oprah," leading her to get a brief restraining order against him. Peck described his character as having a Jackie Gleason quality, and said, "Not only can Josh do the physical comedy and the pratfalls, but he can also sell a sophisticated joke and a touching moment." His character is similar to that of Joey Gladstone and Danny Tanner from Full House for his maturity and responsibility.
 Audrey Parker-Nichols (Nancy Sullivan) is Drake and Megan's biological mother, Josh's stepmother and Walter's wife. Her first name is never mentioned in the series, although a deleted scene from the series finale would have revealed Audrey. The scene would also specify her profession as a caterer.
 She often tells the boys to be more mature. She upsets her husband, Walter, because of her preference for Bruce Winchill, his rival weatherman. Because Walter lacks respect from Megan and Drake, she usually has to punish them, although these punishments are usually unfair because most of the boys' wrongdoings are Megan's fault. As stepmother and stepson, Audrey and Josh have a very close relationship and he affectionately calls her "Mom" or "Mama." She is a nurturing and supportive mother. However, she is a bit gullible when it comes to her daughter Megan, especially when it is Megan's word against Drake and Josh.
 Walter Nichols (Jonathan Goldstein) is Josh's biological father, Drake and Megan's stepfather and Audrey's husband. He is a meteorologist for a local TV news program in San Diego, but he is often wrong about the weather. Walter is often slow-witted, awkward, out-of-touch, and old-fashioned. As a result, he lacks the respect of his stepchildren combined with their arrogances, who refer to him by his first name, although they still do call him "dad" at times. When Megan calls him by his first name, he always asks when she started calling me Walter and Audrey replies, "I don't know." He is also oblivious and cynical regarding Megan's pranks, which have caused the boys many punishments. However, starting in the episode "The Demonator," Walter slowly begins to notice Megan's evil ways. A running gag involves a rivalry between him and Bruce Winchill, an unseen weatherman from another station. He hates that Winchill is so popular, as he is always right with his predictions. He even forbids the use of Winchill's name in the family home.
 Megan Parker (Miranda Cosgrove) is the younger biological sister of Drake, stepsister of Josh, biological daughter of Audrey and stepdaughter of Walter. Megan often references a best friend named Janie and often refers to her older brothers as "boobs." She is essentially the main antagonist of the series, usually bullies her brothers, although sometimes Megan helps them in episodes like “The Gary Grill”, “Honor Council”, “The Drake and Josh Inn” and “Drake and Josh: Go Hollywood.” It has also been shown that she is very wise and intelligent; she can play very severe, torturous and sometimes complicated (or even potentially dangerous) pranks on her brothers, all while ensuring that her parents think of her as being a sweet, angelic, harmless, and innocent little girl. However, in numerous episodes like “The Bet” and “The Affair,” Megan had made rude remarks to Drake and Josh in front of her mother, who does not intervene, and also in “Really Big Shrimp” when she sassed off to Lula when she rudely demanded Megan guacamole, with Walter intervening instead of her mother.  Another episode shows that she has a hidden computerized monitor in her room, giving her surveillance of the house to aid in her pranks against Drake and Josh. Most of the time throughout the series, Megan is very vain, mean-spirited, selfish, bored, devious, bratty, snotty, rude, conceited, snobbish, argumentative, spiteful, disrespectful, hypocritical, deceitful, obnoxious, arrogant, bossy, spoiled, vindictive, and cruel to her brothers. However, despite her mistreatment of them, Megan loves her brothers deep down. She had shown them genuine love and support when they uncovered that her boyfriend Corey (Christian Vandal) had been cheating on her with another girl named Monica. Although she does get in trouble at times such as in "Treehouse" when she's forced to help rebuilt their neighbor's treehouse. Her character is similar to characters such as Sam Puckett (due to her sassy attitude and violent behavior) and Chuck Chambers (due to her pranks) from iCarly and Jade West from Victorious, both shows of which were later created by Dan Schneider.
 Helen Ophelia Dubois (Yvette Nicole Brown) is the manager of the Premiere Theater, connected to the Premiere Galleria mall. She is Josh's boss at the theater and is known for her intimidating demeanor, loud voice, and demanding attitude towards employees. She adores Drake but dislikes Josh despite the hard work he puts in at the theater. She starred in the hit 1970's TV series called Happy Times, which is intended to reference the real-life series called 'Good Times'. She married Buzz Baxter in "Drake & Josh: Really Big Shrimp" and starts finally treating Josh with respect, but divorced him sometime before Merry Christmas, Drake & Josh after five weeks. Yvette Nicole Brown played Helen for most of the series, except the season two episode "Little Diva," in which Frances Callier took over the role.
 Helen appears in a 2011 episode of Victorious in which she becomes the principal of Hollywood Arts High School. She later appears in a 2015 episode of Game Shakers, in which she hosts her talk show titled The Helen Show.
 Steve (Jerry Trainor) is an employee at the Premiere movie theater who is noted for his emotional and mental instability, lashing out at co-workers, strangers, and passersby over little things. He is also incredibly sensitive. Steve takes offense at the slightest of subjects or even the most thoroughly minor hints at insults, hollering at others for interrupting him or denying his questions, desires, or offers. Steve's utter lack of sanity has earned him a dangerously unpredictable reputation amongst colleagues, to the extent where he finds immense frustration in following along with episodes of Dora the Explorer, screaming at the animated characters on the screen. In seasons 2 and 3, he had a lot of hair, but in season 4, his head was shaved. He appears in the program's 2008 Christmas special, most notably towards its conclusion, where he shreds hunks of cheese in a wood chipper to grant his friends' wish for a white Christmas. He later appeared in an episode of the series Sam & Cat where he is revealed to have been placed at a mental institution for the sick, with a restrictive mask over his face.
 Mindy (Allison Scagliotti) is a clever but arrogant girl at school who is always trying to be better than Josh, who is her rival. She also shows an intense dislike for Drake, and the feeling is mutual. One of Mindy's well-known character traits is her genius-level intellect and scientific talents. She defeats Josh yearly in the science fair except for one year after they started to date, where she let him win.
 Craig (Alec Medlock) and Eric (Scott Halberstadt) are a duo of stereotypical honor students that are always being exploited by Drake, mostly due to his hare-brained schemes. Drake often mistakes Eric for Craig when Craig is absent. Eric first appeared in the pilot episode as an extra and along with his best friend, Craig, a few times in Seasons 2 and 3, but they occur more frequently in Season 4 and appear in the series finale Really Big Shrimp. Eric left for Puerto Rico in the final episode, "Dance Contest." Craig and Eric appear with another Drake & Josh character, Gavin, in the 2010 iCarly episode "iStart a Fan War", implying that the two series take place within the same universe.
 Gavin (Jake Farrow) works with Josh at the Premiere, and he has a mullet-like haircut similar in fashion to Rod Stewart (in "Who's Got Game" he got a perm). Throughout the series, a running gag involved Helen asking him to tell Josh to clean something unusual in the theater. He usually declines to do it himself when Josh asks if he would do it. He then cleans up the mess himself - telling Josh, "I got it." He also has a crush on Audrey. He first appeared in "Driver's License" and made an appearance in Merry Christmas, Drake & Josh. Gavin appears in iCarly in Season 4 episode "iStart a Fan War" with Craig and Eric.
 Mrs. Hayfer (Julia Duffy) is the boys' English teacher who adores Josh due to his hard-working personality but hates Drake because of his consistently poor performance in school; likewise, as noted by his doodles of her in his notebook, as seen in "Honor Council," Drake hates her in return. In the episode "Mean Teacher," Mrs. Hayfer is shown to hate Drake for no apparent reason expect for how he shrugs school off and doesn't do outstanding work much as it is shown that when he answered a question correctly, she dubbed it incorrect and appointed the same problem correct to another student right next to him as well as grading a flawless report he did with a "D−" again for no logical reason. In fact, her catchphrase is "I hate you, Drake," with Drake responding, "I know." She also always says, "To the nurse!" which is her way of telling people to leave her classroom. In "Little Sibling," Mrs. Hayfer says it to Josh when she wanted to have a private talk with Drake. Mrs. Hayfer has a daughter named Kelly, who Drake briefly dates, much to her discontent. In "Honor Council," she comes into the classroom to find her car parked where the boys' seats are initially and accuses Drake of putting the car there, but her star student, Mindy, is the real culprit. Drake hates Mrs. Hayfer so much that he wishes she would die, as seen in the episode, "Megan's First Kiss," in which Josh says, "You're not gonna believe this," and Drake asks in an anxious and excited tone, "Mrs. Hayfer died?!"
 Mrs. Hayfer has a Rottweiler named Tiberius, who appears in the season 4 episode "Vicious Tiberius" and is violent towards Drake and Josh, who had agreed to house sit for her.
 She has a brief appearance in Merry Christmas, Drake & Josh, where Drake accidentally hits a fire hydrant while driving, resulting in water getting sprayed all over her. She then points out and yells her famous line: "I hate you, Drake Parker!" Meaning that even though Drake and Josh have graduated from Bellview High, Mrs. Hayfer still hates Drake.
 In the season 2 finale, "Honor Council," Josh mentions her full name as Alice Hayfer. However, in "Vicious Tiberious," a video shows her full name as being Linda Hayfer.
 Dr. Glazer (Roark Critchlow) is a doctor who lives across the street from the boys. He is always called on whenever a severe emergency happens at their house. Although he always seems kind while performing medical procedures for the boys, he still leaves them with a ridiculously high bill for his services (he once charged $100 for diagnosing a sheep as pregnant after it had already given birth and an extra $50 not to tell Audrey and Walter, charged $300 for diagnosing Drake's facial rash, and charged $500 for diagnosing Ashley Blake's accident after she got hit in the head with a bucket). He first appeared in "The Bet," and he last appeared in "Sheep Thrills."
 Although Bruce Winchill is never seen in Drake & Josh, he is mentioned throughout the series. Megan and Audrey have a crush on him because he has good hair. He is a rival weatherman of Walter, and he always gets the weather right.
 Drake has several girlfriends throughout the series.
 Susan (Ashley Drane) is Drake's girlfriend in the episode "Believe Me, Brother," in which she secretly flirts with Josh. She is later exposed, and as revenge, Drake and Josh plant purple paint in her locker, and it is splattered all over her when she opens the door.
 Kelly Hayfer (Chelsea Brummet) is Mrs. Hayfer's daughter. She appears only in the episode "Mean Teacher," in which she dates Drake. She has a laughing problem throughout the episode, which secretly annoys Drake. However, he does not break up with her, fearing retaliation from Mrs. Hayfer. Although Kelly loves Drake, she ends the relationship – much to his excitement – because she does not believe it is working out.
 Tori (Torrey DeVitto) is Drake's girlfriend in the episode "Playing the Field," in which he breaks up with her. When Tori quickly begins dating other boys, Drake dates Liza Tupper – who he has nicknamed Hot Liza – to make Tori jealous. In the episode "Dr. Phyllis Show," it is mentioned that Liza is the daughter of Dr. Phyllis, the host of a television talk program when the host becomes angry after Drake insults Liza by calling her dumb and a bad kisser.
 Lucy (Gabrielle Christian) is introduced in the episode "Girl Power," in which she physically defends Drake against a football player. Drake then considers ending their relationship, as he does not want to be with someone stronger than him. Later in the episode, Drake and Lucy wrestle to determine who is stronger, although Drake is hesitant about wrestling a girl.
 Carly (Brittany Curran) becomes Drake's girlfriend in the episode "Who's Got Game," in which Josh challenges Drake on who can get the most dates. Drake meets her at the CD shop where she works, and he falls in love with her at first sight. Carly grows fond of Drake, too, after meeting him but furiously dumps him when she finds out about the bet, thinking Drake is just using her. He then proves to her that he can be honest and they continue dating.
 Lucy and another girl, Christine (Sarah Christine Smith), appear as ex-girlfriends of Drake in the episode "The Storm." They become friends with Carly, who is still dating Drake. The episode marks their final appearance on the series. Drake flirts with other girls, including Grant Widner, in subsequent episodes such as "Tree House."
 Drake has a band in which he is both the frontman and lead guitarist.
 Scottie (Johnny Lewis) is the drummer of Drake's band and is Trevor's younger brother. He is considered to be unintelligent, according to Drake and the other band members. Rina (Molly Orr) is the bassist of Drake's band, while Paul (Jeremy Ray Valdez) is the rhythm guitarist. They only appeared in four episodes in Season 1. Drake and the three band members are detained at a concert because Scottie photocopied their tickets in the episode "Grammy," the three's final appearance.
 In the episode "Megan's New Teacher," Drake has 5th grader Neil Kramer (Ridge Canipe) play in his band after his original drummer leaves. Neil initially fails a pop quiz by Josh, who is serving temporarily as a student-teacher. Neil's mother then forbids him from playing in the band, so Drake and Megan get Josh fired, leading to Neil playing for Drake's band at the Premiere's third anniversary. Neil does not appear in any subsequent episodes.
 Three band members, Gary (Dan Mott), Julio (Shiloh Fernandez), and an unnamed guitarist, appear in "The Storm." Gary is the goofy and self-absorbed drummer. He has a tattoo of a foot on his chest and likes to wear girls' shirts, including his sister Elaine's blouse and Megan's panda shirt. Julio is the band's bassist, and he was mentioned in the episode "Josh Runs Into Oprah." The rhythm guitarist is an African American but is only seen with the band.