Lake Erie Watershed is a major drainage catchment in northwestern Pennsylvania, United States, consisting of lands with direct runoff and sub-watersheds with waterways that flow into Lake Erie and Presque Isle Bay from Crawford and Erie counties, as well as from New York. The watershed is part of the Lake Erie Basin.
 Averill Creek is also called 41.5 Mile Run.
 Cemetery Run
begins north of E 38th near Millcreek proceeding through Roma Park before continuing to the lake by Lakeside Cemetery, with many portions running underground, due to development, or through culverts.
 Crooked Creek
 Some Pennsylvania lands have surface runoff that drains directly into Lake Erie. 24 such stretches of land can be identified.
 Erie International Airport is located in the largest of these direct runoff zones, west of the City of Erie, between Walnut Creek and Cascade Creek sub-watersheds. The airport's Master Plan includes a water quality section in its Environmental Baseline Study (Chapter 3, Section 3.07).
 The master plan positions the airport in Lake Erie Watershed, 9,000 feet (2,700 m) north of Walnut Creek Sub-watershed, 12,000 feet (3,700 m) west of Cascade Creek Sub-watershed, and five miles (8 km) west of Mill Creek Sub-watershed, which is part of the Presque Isle Bay Watershed. The plan notes that Wilkins Run, a tributary (sic) that drains directly into Lake Erie, is situated 1,000 feet (300 m) west of the airport.
 Storm drainage is identified in the master plan as the main potential water pollution danger. Construction and deicing operations require federal permits and extensive measures are taken to contain and process the runoff properly. A report detailing these measures is included at the end of the airport's master plan, entitled Airport Drainage Master Plan.
 Duck Run
 Eightmile Creek (Pennsylvania)
 This sub-watershed consists of Elk Creek and surrounding lands, including the northeastern quarter of Elk Creek Township, the northern two-thirds of Franklin Township, and much of central Girard Township in northwestern Erie County, Pennsylvania.
 Elk Creek is one of three western Erie County tributaries thought to be raising E. coli counts off Lake Erie beaches at nearby Presque Isle State Park.
 Fourmile Creek Sub-watershed consists of the 11.93-square-mile (30.9 km2) drainage of the 8-mile-long (13 km) Fourmile Creek. The creek's mouth opens to Lake Erie about one-half mile north of Pennsylvania Route 5 at Water Street. It draws its name from its location four miles (6 km) east of the center of Erie, Pennsylvania. The watershed consists of portions of Greene, Harborcreek, and Lawrence Park townships, as well as Wesleyville, Pennsylvania. Fish migration improvement projects have included the destruction of two dams in 2007 and the planned construction of two fish ladders in 2008. Projects to stem sedimentation due to soil erosion were planned for 2008.
 Godfrey Run is also known as 11.5 Mile Run.
 This sub-watershed consists of McDannell Run and the surrounding lands of the City of Erie. The sub-watershed crosses slightly into Millcreek Township. The run passes through McClelland Park, an undeveloped city park on the eastern side of the city.
 Orchard Beach Run is also called 39.9 Mile Run.
 This watershed, which covers 65 km2, consists of lands in the City of Erie and two neighboring townships which surround three direct runoff zones, including Presque Isle State Park, and two sub-watersheds, which all feed into Presque Isle Bay. At its eastern extreme, the bay has a small channel that drains into Lake Erie. The Environmental Protection Agency (EPA) has designated this watershed a Great Lakes Areas of Concern (AoC). The land is 80% urbanized, with storm water often diverted, causing degradation of fish habitat and other problems. An assessment of fishes published in Northeastern Naturalist magazine in 2004 found that at least half of the stream fish assemblages tested were impaired by urbanization. The city focused its attention on this watershed as part of its effort to convert Erie from heavy industry to light industry and tourism.
 Purdue Creek is also called 40.9 Mile Run.
 Raccoon Creek
 Sevenmile Creek
 6.7 Mile Run
 Sixmile Creek
 Sixteenmile Creek
 10.0 Mile Run
 3.9 Mile Run
 3.2 Mile Run
 This sub-watershed consists of Trout Run and surrounding lands of northwestern and south central Fairview Township. The sub-watershed is situated primarily north of I-90. The sub-watershed touches across the Fairview border into McKean and Girard Townships.
 Trout Run is one of three western Erie County tributaries thought to be raising E. coli counts off Lake Erie beaches at nearby Presque Isle State Park.
 Twelvemile Creek
 Twentymile Creek extends into New York
 29.0 Mile Run
 26.9 Mile Run
 This sub-watershed consists of Walnut Creek and surrounding lands of the City of Erie, Fairview Township, Greene Township, McKean Township, Millcreek Township, and Summit Township. Significant developments in this sub-watershed include Asbury Woods Community Park and Nature Center, Baldwin Business Park, Bush Industries, Erie Golf Club, Erie Memorial Gardens, Family First Sports Park, Kahkwa Club, Lakeview Landfill, Laurel Hill Cemetery, Millcreek Mall, Orchard Ponds Golf Course, Presque Isle Downs, and Upper Peach Street.
 A detailed online report on the Walnut Creek watershed is available from the Pennsylvania Department of Environmental Protection (PA DEP).
 The Lakeview Landfill is a PA DEP-permitted surface mining operation.
 The inclusion of a race track at Presque Isle Downs and Casino will bring up to one thousand horses to fill ten barns on the grounds by summer 2008. The horses are expected to produce up to ten tons of manure and hay waste per day, which will be transported and sold. Fifteen acres of man-made wetlands have been situated in the center of the racetrack to deal with runoff issues that could impact the watershed.
 Most sewage waste is processed at the Erie Wastewater Treatment Facility and released two miles (3 km) out in Lake Erie. There are 28 privately owned waste treatment plants that release directly into the watershed.
 There are three companies in the watershed with industrial stormwater release permits from PA DEP.
 Walnut Creek is one of three western Erie County tributaries thought to be raising E. coli counts off Lake Erie beaches at nearby Presque Isle State Park.
 42°00′N 80°08′W﻿ / ﻿42.000°N 80.133°W﻿ / 42.000; -80.133