The Palouse /pəˈluːs/ are a Sahaptin tribe recognized in the Treaty of 1855 with the United States along with the Yakama. It was negotiated at the 1855 Walla Walla Council. A variant spelling is Palus. Today they are enrolled in the federally recognized Confederated Tribes and Bands of the Yakama Nation and some are also represented by the Colville Confederated Tribes, the Confederated Tribes of the Umatilla Indian Reservation and Nez Perce Tribe.
 The people are one of the Sahaptin-speaking groups of Native Americans living on the Columbia Plateau in eastern Washington, northeastern Oregon, and North Central Idaho: these included the Nez Percé, Cayuse, Walla Walla, Umatilla and the Yakama.
 The Palouse (Palus) territory extends from the confluence of the Snake and Clearwater Rivers in the east to the confluence of the Snake and Columbia Rivers in the west. It encompassed the Palouse River Valley up to Rock Lake in the north and stayed north of the Touchet River Valley in the south. To the north, their territory bordered the Sinkiuse-Columbia, Spokane, and Coeur d'Alene; to the east, their territory bordered the Nez Perce; to the south, the Cayuse and Walla Walla; and to the west, they bordered the eastern boundary of the Yakama and Wanapum territories. The Palouse (Palus) lived in three main regional bands, composed of several village-based groups:
 The ancestral people were nomadic, following food sources through the seasons. The Palus people gathered with other native peoples for activities such as food-gathering, hunting, fishing, feasting, trading, and celebrations that included dancing, sports and gambling. They lived near other groups including the Nez Perce, Wanapum, Walla Walla, Umatilla and Yakama peoples.
 The present tribal designation probably derives from the proper designation of the most populous of the three regional bands of the Palouse/Palus people - the ″Middle Palouse/Palus Band″ as Palúšpam - "people of Pa-luš-sa/Palus [one of their most important settlements]", the neighboring Nez Percé also called them Pa-loots-poo/Pelú`cpu/Peluutspu and the Yakama Palúuspam/Pelúuspem both meaning "people of Pa-luš-sa/Palus", their proper autonym was Naxiyamtama or Naha’ámpoo/Naha'u'umpu'u - “the river people”.
 The people were expert horsemen. The term Appaloosa is probably a derivation of the term "A Palouse horse." They bred the horses for their distinct markings. In the latter half of the nineteenth century, the United States Army captured and slaughtered hundreds of tribal horses to cripple the tribe during the Indian Wars.
 In October 1805, Lewis and Clark met with the tribe, although most were away from the area for fall food-gathering and hunting. Lewis and Clark presented one of the expedition's silver peace medals to paramount Chief Kepowhan. The Diaries of the Corps of Discovery describe the people as a separate and distinct group from the Nez Percé.
 After Kepowhan, during the decades 1830', 1840', 1850, Wattaiwattaihowlis (Kepowhan's son and probably principal chief), Kahlotus (known also as Quelaptip and Talatuche, chief of the Upper Palouse), Soei (chief of the Middle Palouse), Nehtalekin (called also Hahtalekin the Elder), Tilcoax (chief of the Lower Palouse), Hinmahtutekekaikt alias “James” (one among the first to be Christianized, friend to Henry H. Spalding and Marcus Whitman, often associated to the Nimiipu band of Hollolsotetote), were the leaders until the Isaac I. Stevens Treaty in 1855, when the Palouse refused to take part but sent, as observers, Kahlotus (already a good friend to Marcus Whitman), Tilcoax (a war chief) and Slyotze; "Old" Hathalekin and Tilcoax led the Palouse warriors against the U.S. troops during the Cayuse's uprising in 1847–1848, defeating col. Cornelius Gilliam and his "Oregon Volunteers" on the Tucannon Creek (March 14–15, 1848). In 1858 Tilcoax led again the Palouse warriors in the "Skitswish (Coeur d'Alene) War": in May 1858 the Palouses succeeded in taking possession of an herd of Army's horses, but, on September 8, 1858, their own herd of 800 horses was slaughtered by col. George Wright's soldiers, and they surrendered.
 Husishusis Kute, chief of the Wawawai Palouse, and "Young" Hathalekin (also known as Taktsoukt Jlppilp), war-chief, led a small Palouse band as allies of the last free Nimiipu of Heinmot Tooyalaket alias "Chief Joseph"; "Young" Hathalekin died fighting on August 9, 1877, at Big Hole; Husishusis Kute surrendered with Heinmot Tooyalaket on October 5, 1877.
 Palouse Chiefs