The Volleyball 2021–22 V.League Division 1 Women's is the 28th volleyball tournament year and includes the 4th top level women's volleyball tournament of the newly branded and reorganized V.League (Japan) scheduled for October 15, 2021 to  April 17, 2022.
 The V.League Division 1 Women's teams compete in four tournaments each year:
 
 The number of foreign players is restricted to one per club worldwide plus one per club from ASEAN nations.
  Adastria Arena, Mito
Ageo City Gymnasium  (ja)
 Baycom Gymnasium, Amagasaki (ja)
Brex Arena, Utsunomiya
 CNA Arena, Akita
Fukuoka Citizens Gymnasium
 Deai Dome, Gifu
 Green Arena, Kobe
Higashiyama Gymnasium, Ichinoseki
 Hiroshima Green Arena
Hitachinaka Sports Facility (ja)
 Ikenokawa Sakura Arena, Hitachi
 
  Kanazawa City Gymnasium
 Kasaoka Gymnasium, Okayama (ja)
 Kawagoe Sports Park, Saitama
 Kitagas Arena, Sapporo (ja)
Komatsu City Gymnasium, Ishikawa
 Konohana Arena, Shizuoka
 Horaiya Koriyama Gymnasium
Kose Sports Park Gymnasium, Kofu (ja)
Kurobe General Sports Center (ja)
 Kurume Arena, Fukuoka
 Maruzen Intec Arena, Osaka
 Muko Citizens Gymnasium, Kyoto
 
 Nishio City Gymnasium (ja)
 Okazaki Park Gymnasium, Aichi
 Ota Ward Gymnasium, Tokyo
Saga Sunrise Park Gymnasium
 Saiden Chemical Arena, Saitama (ja)
 Saitama Prefectural Budokan, Ageo (ja)
Sanyo Fureai Park Gymnasium, Akaiwa
 Shimadzu Arena, Kyoto (ja)
Shiwa Town Gymnasium, Iwate
Sky Hall Toyota
 Sumiyoshi Sports Center, Osaka
Sun Arena Sendai (ja)
 
 Sun Arena Wajima, Ishikawa
Todoroki Arena, Kawasaki
Toyama City Gymnasium
 Toyama Seibu Sports Center, Tonami
Trim Park Kanazu, Awara (ja)
 Ukaruchan Arena, Otsu
Wing Arena Kariya
Wink Gymnasium, Himeji
YMIT Arena, Kusatsu  (ja
Yokkaichi City Gymnasium
 Zip Arena, Okayama
  
  Konohana Arena, Shizuoka
 
 
  
 Regular Round begins October 15, 2021 (Saturday) and ends March 27, 2022 (Sunday). Matches are played every Saturday and Sunday along with a couple Friday Night matches.
 Final Stage begins April 9, 2022 and ends April 17, 2022.
 V.Challenge Match (V1-V2 Promotion-Relegation Matches): TBD
 The team with the most wins will be ranked highest
 Points awarded for a match as follows:
 If a team abstains for some reason, it will be considered to have lost the game 0-25, 0-25, 0-25
 Tie Breakers are as follows:
 
 Round 1 October 15–17, 2021
 Round 2 October 23–24, 2021
 Round 3 October 30–31, 2021
 Round 4 November 6–7, 2021
 Round 5 November 12–14, 2021
 Round 6 November 20–21, 2021
 Round 7 November 27–28, 2021
 Round 8 December 4–5, 2021
 Winter break December 6, 2021 to January 9, 2022
Empress' Cup Final Round held December 10–19, 2021 (Hisamitsu Springs wins)
 Round 9 January 8–9, 2021
 Round 10 January 15–16, 2022
 Round 11 January 22–23, 2022
 Round 12 January 29–30, 2022
 Round 13 February 5–6, 2022
 Final 3
 FINAL
 The 2nd round of the FINAL, scheduled for April 16, 2022, was canceled due to several players from both teams having tested positive for the new coronavirus.
 Hisamitsu Springs, who won the first round of the final on April 10, 2022 with a set count of 3-1 will be ranked the highest, the victory will be confirmed, and they are given the Title of Season 2021-22 Champions. JT Marvelous are runners up. 
 Libero: Yuka Ikeya, Mana Toe
MB: Ayaka Araki, Shion Hirayama, Asuka Hamamatsu, Foluke Akinradewo, Riho Ōtake
OP: Miyu Nakagawa, Miyu Nagaoka, Akari Shirasawa
OH: Arisa Inoue, Yuki Ishii, Hikari Kato, Rika Nomoto, Yuka Imamura, Megumi Fukazawa, Saki Nakajima, Mika Yoshitake
  
 V.Challenge Match Women's tournament held April 9–10, 2022
 If a V2 team does not have an S1 license, they will not play the tournament, and their V1 opponent remains in V1 unchallenged.
 Teams with the most wins will qualify for next season's V1 League. In the case of 1 win and 1 loss, the following will be used as tiebreakers:
 Points are awarded as follows:
 Match Results
 Match Results