The 2018 Kansas City Chiefs season was the franchise's 49th season in the National Football League, their 59th overall, their sixth under head coach Andy Reid, and their second under general manager Brett Veach. The Chiefs finished 12–4 and won their third consecutive AFC West title, made their fourth consecutive playoff appearance, but lost to the eventual Super Bowl champion New England Patriots in the AFC Championship. Quarterback Patrick Mahomes won the AP NFL MVP award, becoming the first Chiefs player to ever be named MVP.
 In the offseason the Chiefs had several major changes, including trading 2-time Pro Bowler Marcus Peters, as well as Alex Smith. The team also voided the final year of the contract of their longest tenured player Derrick Johnson and they released long time linebacker Tamba Hali.
 Under first year starting quarterback Patrick Mahomes, the Chiefs would start the season 5–0 for the second consecutive year before losing to the New England Patriots. The Chiefs then won their next four games before losing again to the Los Angeles Rams. A Week 14 win over the Baltimore Ravens clinched the Chiefs' fourth consecutive playoff appearance. After defeating their rival, the Oakland Raiders 35–3 in Week 17, the Chiefs clinched their third consecutive division title and home-field advantage throughout the playoffs for the first time since 1997.
 In the playoffs, the Chiefs advanced to the AFC Championship Game for the first time since 1993 by defeating the Indianapolis Colts, 31–13 in the divisional round.  This win ended the Chiefs' 6-game home playoff losing streak dating back to 1993. It was only the Chiefs' second win in their last 13 playoff games. In the AFC Championship Game, the Chiefs lost to the eventual Super Bowl champion New England Patriots, 37–31 in overtime. Two days after the loss, defensive coordinator Bob Sutton was fired following multiple NFL analysts criticizing his lack of adjustments in the AFC Championship Game, as well as other games throughout the season.
 The Chiefs had three players ranked in NFL Network's annual Top 100 players countdown, the fewest the team has had on the list since 2012.
 *Did not finish the season on the roster
 Trades
 Head coaches
 Offensive coaches
 Special teams coaches
 Strength and conditioning
 Running backs
 Wide receivers
 Tight ends
 Defensive linemen
 Defensive backs
 Special teams
 
Practice squad
 
Rookies in italics
53 active, 12 inactive, 10 practice squad
 at Arrowhead Stadium, Kansas City, Missouri
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 at Mercedes-Benz Stadium, Atlanta, Georgia
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 at Soldier Field, Chicago, Illinois
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 at Arrowhead Stadium, Kansas City, Missouri
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 Notes
 at Stubhub Center, Carson, California
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 at Heinz Field, Pittsburgh, Pennsylvania
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 at Arrowhead Stadium, Kansas City, Missouri
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 This game was Patrick Mahomes’ home debut at Arrowhead Stadium, which also happened to be against the team Mahomes would eventually defeat in his first Super Bowl victory.
 at Broncos Stadium at Mile High, Denver, Colorado
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 at Arrowhead Stadium, Kansas City, Missouri
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 at Gillette Stadium, Foxborough, Massachusetts
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 at Arrowhead Stadium, Kansas City, Missouri
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 at Arrowhead Stadium, Kansas City, Missouri
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 With this win, head coach Andy Reid eclipsed win number 200, becoming the seventh coach in NFL history to do so (with Don Shula, George Halas, Bill Belichick, Tom Landry, Curly Lambeau, & Marty Schottenheimer).
 at FirstEnergy Stadium, Cleveland, Ohio
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 With this win, head coach Andy Reid won his 201st regular season game, passing Marty Schottenheimer to move to 6th most regular season wins in NFL history.
 at Arrowhead Stadium, Kansas City, Missouri
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 at Los Angeles Memorial Coliseum, Los Angeles, California
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 at Oakland–Alameda County Coliseum, Oakland, California
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 at Arrowhead Stadium, Kansas City, Missouri
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 at Arrowhead Stadium, Kansas City, Missouri
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 at CenturyLink Field, Seattle, Washington
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 at Arrowhead Stadium, Kansas City, Missouri
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 With this win, head coach Andy Reid won his 206th combined regular season & post season game, passing Marty Schottenheimer to move to 7th most combined wins in NFL history.
 at Arrowhead Stadium, Kansas City, Missouri
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 at Arrowhead Stadium, Kansas City, Missouri
 First Quarter
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 Overtime
 Top passers
 Top rushers
 Top receivers