Hell Is Real is a rivalry between the two Major League Soccer (MLS) clubs based in Ohio: the Columbus Crew and FC Cincinnati. Under current MLS regular season scheduling, the series occurs twice per season as both teams are members of the Eastern Conference. The teams first met in 2017 in the U.S. Open Cup before Cincinnati joined MLS in 2019.
 Hell Is Real takes its name from a Christian highway billboard located on Interstate 71 between Columbus and Cincinnati. The two team's MLS Next Pro affiliates, the Columbus Crew 2 and FC Cincinnati 2, parody Hell Is Real for their matches and use the name Heck is Plausible.
 FC Cincinnati was founded in 2015 as a United Soccer League club. After three seasons in the second-division league, Cincinnati moved to MLS in 2019 and joined the Columbus Crew, who had been a league member since their inaugural season in 1996. Two weeks after the Cincinnati expansion announcement, the Ohio clubs met for the first time with lower-league Cincinnati winning 1–0 in the U.S. Open Cup.
 In October 2017, Columbus owner Anthony Precourt threatened to move the team to Austin, Texas, putting the prospect of an MLS rivalry between the two Ohio teams in jeopardy. Precourt's proposed relocation sparked outrage in the American soccer community, creating the #SaveTheCrew movement. After a year of support by fans, rival teams, local businesses, and politicians, the Crew committed to staying in Columbus in November 2018, when the Haslam family (owners of the NFL's Cleveland Browns, which had been the subject of a controversial relocation in the 1990s) purchased the club.
 The two teams met for the first time in the fourth round of the 2017 U.S. Open Cup, while FC Cincinnati was still a member of the United Soccer League. Cincinnati won the match 1–0 on a goal from Djiby, knocking Columbus out of the tournament and advancing to the quarterfinals.
 On August 10, 2019, the two sides played against each other in MLS league play for the first time, ending in a 2–2 draw at Mapfre Stadium. Columbus earned their first win of the series in that season's reverse fixture with a 3–1 victory. The highest-scoring match came in 2021, when the Crew pulled off a late comeback at their new Lower.com Field; holding a 2–1 lead in the 75th minute, FC Cincinnati surrendered two late goals to lose 3–2.
 The first MLS Cup Playoffs match between the two teams took place in the Eastern Conference Final on December 2, 2023. The match was hosted by FC Cincinnati and resulted in a 3–2 victory for the Columbus Crew after FC Cincinnati led 2–0 in the first half but conceded two goals in the second half. The Crew went on to score the winning goal in the 25th minute of extra time, enabling them to win the MLS Cup the following week.
 The rivalry's name was created by fans of both teams in 2017, prior to the first competitive meeting in the U.S. Open Cup. It is derived from a religious sign that reads "HELL IS REAL" located on Interstate 71, the highway that connects Columbus and Cincinnati–a distance of 110 miles (180 km). The sign was installed in 2004 on a local farm in Chenoweth by a Kentucky developer who had installed similar religious signs in other states.
 The rivalry has an alternate name, Heck is Plausible, between both club's MLS Next Pro teams, Columbus Crew 2 and FC Cincinnati 2.
   Columbus Crew win
  FC Cincinnati win
  Draw
 † Matches played behind closed doors or reduced capacity due to the COVID-19 pandemic.
 ‡ Although the match was part of the MLS is Back Tournament, group stage matches count toward regular season MLS statistics.
   Columbus Crew
  FC Cincinnati
 • Total: Columbus with 3 higher finishes, FC Cincinnati with 2.