The Burning Secret Of Fat…
By: Dimitri Stanoulis
Tags: Weight Loss, Weight Loss Supplements, Natural, Weight Loss Tips, Obesity

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is unclear. Here we retrospectively categorized 134,529 18F-fluorodeoxyglucose positron emission tomography–computed tomography scans from 52,487 patients, by presence or absence of BAT, and used propensity score matching to assemble a study cohort. Scans in the study population were initially conducted for indications related to cancer diagnosis, treatment or surveillance, without previous stimulation. We report that individuals with BAT had lower prevalence’s of cardiometabolic diseases, and the presence of BAT was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension. These findings were supported by improved blood glucose, triglyceride and high-density lipoprotein values. The beneficial effects of BAT were more pronounced in individuals with overweight or obesity, indicating that BAT might play a role in mitigating the deleterious effects of obesity. Taken together, our findings highlight a potential role for BAT in promoting cardiometabolic health.

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As early as 2003, reports described increased uptake of the glucose analog 18F-fluorodeoxyglucose (18F-FDG) on positron emission tomography (PET) scans in areas corresponding to supraclavicular fat on computed tomography (CT) images, suggesting the presence of metabolically active BAT in adult humans. In 2009, a series of papers confirmed the presence of active BAT in adults, which correlated with lower body mass index (BMI), decreased age, colder outdoor temperature, female sex and decreased glucose levels. Since then, small prospective studies in healthy humans have demonstrated that cold-activated BAT is associated with increased energy expenditure and enhanced disposal of glucose and free fatty acids.

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Reference: www.nature.com/articles/s4159–020–1126–7

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