LIVE’™!!*~ 49ers vs Cardinals Live Stream 2021 — San Francisco 49ers vs Arizona Cardinals Live
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Live Now::https://tinyurl.com/y2v8qpwc

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The San Francisco 49ers are 2–7 against the Arizona Cardinals since October of 2016, but they’ll have a chance to close the gap a little bit on Saturday. San Francisco and Arizona will face off in an NFC West battle at 4:30 p.m. ET at State Farm Stadium. With a combined 984 yards of offense in their previous games, we can expect a fast-paced game.

It looks like the 49ers must have gotten on Santa’s naughty list since the squad didn’t end up with the win they were expected to receive this past Sunday. They fell to the Dallas Cowboys 41–33. One thing holding San Francisco back was the mediocre play of QB Nick Mullens, who did not have his best game: despite two touchdowns, he threw two interceptions and fumbled the ball once. Mullens ended up with a passer rating of 116.70.

Arizona decided to play defense against itself this past Sunday, but the team still came out ahead despite their 82 penalty yards. They took their contest against the Philadelphia Eagles 33–26. The team ran away with 26 points in the first half and mostly just sat on those in the second to pick up the victory. It was another big night for Arizona’s QB Kyler Murray, who passed for three TDs and 406 yards on 36 attempts in addition to punching in one rushing touchdown.

The 49ers are now 5–9 while the Cardinals sit at 8–6. San Francisco has been eliminated from playoff contention. Arizona is still in the hunt for a spot in the playoffs, so these next two games are critical for them.

San Francisco is expected to lose this next one by 5. Now might not be the best time to take San Francisco against the spread since they’ve let down bettors for the past three consecutive games.

Two stats to keep an eye on: The 49ers enter the matchup with only ten rushing touchdowns allowed, good for fourth best in the league. But the Cardinals rank second in the NFL when it comes to rushing touchdowns, with 21 on the season. We’ll see if San Francisco’s defense can keep Arizona’s running backs out of the end zone.

How To Watch

When: Saturday at 4:30 p.m. ET

Saturday at 4:30 p.m. ET Where: State Farm Stadium — Glendale, Arizona

State Farm Stadium — Glendale, Arizona TV: Amazon Prime Video

Amazon Prime Video Online streaming: fuboTV (Try for free. Regional restrictions may apply.)

fuboTV (Try for free. Regional restrictions may apply.) Follow: CBS Sports App

Odds

The Cardinals are a 5-point favorite against the 49ers, according to the latest NFL odds.

Over/Under: -111

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Series History

Arizona have won nine out of their last 11 games against San Francisco.

Sep 13, 2020 — Arizona 24 vs. San Francisco 20

Nov 17, 2019 — San Francisco 36 vs. Arizona 26

Oct 31, 2019 — San Francisco 28 vs. Arizona 25

Oct 28, 2018 — Arizona 18 vs. San Francisco 15

Oct 07, 2018 — Arizona 28 vs. San Francisco 18

Nov 05, 2017 — Arizona 20 vs. San Francisco 10

Oct 01, 2017 — Arizona 18 vs. San Francisco 15

Nov 13, 2016 — Arizona 23 vs. San Francisco 20

Oct 06, 2016 — Arizona 33 vs. San Francisco 21

Nov 29, 2015 — Arizona 19 vs. San Francisco 13

Sep 27, 2015 — Arizona 47 vs. San Francisco 7

The fight for a playoff berth continues for the Arizona Cardinals when they host their temporary stadium houseguests the San Francisco 49ers on Saturday afternoon at State Farm Stadium in Glendale, Arizona. This will be the second meeting of the year between these two teams as the Cardinals beat the 49ers in Week 1 24–20 at Levi’s Stadium in Santa Clara.

Arizona (8–6) survived the “Lincoln Riley Classic” last week as Kyler Murray outdueled Jalen Hurts in a battle of former Oklahoma quarterbacks as the Cardinals beat Philadelphia 33–26. Murray threw for a career-high 406 yards as the Eagles’ defense had zero answers for him. DeAndre Hopkins caught nine passes for 169 yards and a touchdown to continue his big first season out in the desert. While Hurts put up big numbers of his own (401 total yards, 4 total TDs), Arizona’s defense was able to limit Philadelphia to just six points in the second half. A big part of that was getting off the field on third down. The Cardinals held the Eagles to 6-for-18 in that critical situation.

On the other side, San Francisco (5–9) fell 41–33 to Dallas on the road. The 49ers gave up 291 total yards to the Cowboys but turned the ball over four times. Nick Mullens posted 219 passing yards with two touchdowns and two interceptions before giving way to C.J. Beathard, who completed five of seven passes for 100 yards and a touchdown. Kendrick Bourne and Brandon Aiyuk were bright spots as they combined to catch 13 passes for 159 yards and two touchdowns between them, but it wasn’t enough as San Francisco lost its third in a row.

San Francisco at Arizona

Kickoff: Saturday, Dec. 26 at 4:30 p.m. ET

TV: Amazon Prime Video/Twitch

Spread: Cardinals -4

Three Things to Watch

1. Arizona offense

Kyler Murray is in an interesting spot this week with the Cardinals getting an opportunity to take a big step towards securing a wild-card berth. In the first meeting with San Francisco back in Week 1, Murray went 26-for-40 for 230 yards, a touchdown and an interception. However, it was his legs that ended up being the difference, rushing for 91 yards and a score on 13 carries in the 24–20 victory. Murray will likely have to do more of the same this time, as neither Kenyan Drake nor Chase Edmonds was that effective in the win over Philadelphia, combining for 73 yards on 21 carries. Murray also has DeAndre Hopkins to throw to. The NFL’s leading receiver (1,324 yards on 103 catches), Hopkins lit up the 49ers for 151 yards on 14 grabs in the first meeting.

2. Can San Francisco play keep away from the Cardinals?

Nick Mullens suffered an elbow injury last week and will miss the rest of the season. C.J. Beathard will take over and while he has plenty of experience under his belt, look for head coach Kyle Shanahan to run the ball a lot. With Raheem Mostert getting shut down for the rest of the season that task will largely fall on Jeff Wilson Jr., who is averaging 4.1 yards per carry and leads the team with six rushing touchdowns. Tevin Coleman and Jerick McKinnon are other possible options, but the former has dealt with injuries (played in just games) while the latter is averaging under four yards per carry, although he has scored six times, five of those coming on the ground. Whoever gets the touches needs to be on the alert for safety Budda Baker. A three-time Pro Bowler following this year’s selection, Baker makes plays all over the field, as evidenced by the 15 tackles he racked up in the first meeting. Another potential difference-makers for Arizona’s D is linebacker Haason Reddick, who is among the league leaders in both sacks (11.0) and tackles for a loss (19).

3. How will Kliff Kingsbury respond to coaching in a game with huge playoff implications?

This will be a great opportunity for Arizona’s second-year head coach to show his mettle. The Cardinals have had issues on occasion under Kingsbury where the team has lost games at home that they had no business losing. The best example of this in 2020 is in Week 3, a 26–23 loss to Detroit. In that game, Arizona outgained Detroit 377–322 and had a 23–20 lead after three quarters, but three turnovers proved to be costly. Saturday’s game with San Francisco has the potential to unfold in a similar fashion if Kingsbury doesn’t have his team ready to play from the opening snap. One way to avoid a slow or flat start would be to play aggressive in all three phases of the game. If that happens, the Cardinals should win this game going away instead of having to hang on for dear life late in the fourth quarter.

Final Analysis

It will be a competitive game for a while in the first half as there is too much pride within the 49ers organization for them to completely give up. Still, the toll of being away from their normal home in Santa Clara County has to show up at some point, not to mention the cumulative effect of all the injuries San Francisco has had to deal with this season. Look for the Cardinals to break the game open in the second half by forcing a couple of turnovers with the offense cashing them in. Arizona takes another step towards a wild-card berth by picking up its ninth win of the season.

Prediction: Cardinals 30, 49ers 17