Date: 201910
Flight conditions: VMC
Light: Daylight
Aircraft: B787 Dreamliner Undifferentiated or Other Model
Operator: Air Carrier
Operating under: Part 121
Flight plan: IFR
Mission: Passenger
Flight phase: Cruise
Airspace: Class A ZZZ
Aircraft component: Pressurization Control System
Component problem: Malfunctioning
Reporter organization: Air Carrier
Reporter function: Captain; Pilot Flying
Reporter qualification: Flight Crew Instrument; Flight Crew Multiengine; Flight Crew Air Transport Pilot (ATP)
Second reporter function: Pilot Not Flying; First Officer
Anomaly: Aircraft Equipment Problem Critical
Detector: Person Flight Crew
When detected: In-flight
Result: Air Traffic Control Issued New Clearance; Flight Crew Diverted; Flight Crew Landed As Precaution; Flight Crew Landed in Emergency Condition; General Flight Cancelled / Delayed; General Maintenance Action
Contributing factors: Aircraft
Primary problem: Aircraft

Narrative: Multiple aircraft systems failures and malfunctions including pressurization in cruise at FL390. Initiated [expedited descent] and diverted to ZZZ. Landed safely with no further incident.


Second narrative: During cruise at FL390; I was Pilot Monitoring while the Captain was Pilot Flying. We noticed that the airflow was disrupted in the cockpit. This normally means one of the CAC's is about to quit so I pulled up the air synoptic page and noticed that the right pack was inoperative. At the same time we got a C Hyd R Pump EICAS. The Captain gave me flying duties and ATC while he ran the checklist. While running the checklist R pack off EICAS appeared. The Captain finished the first checklist and started on the pack checklist when other EICAS messages appeared; APU Starters right and Engine Starter Right. While running the pack checklist I still had the air synoptic page up I noticed now the left pack was inoperative and the cabin altitude started climbing from 6;100 ft. at about 700 fpm. I called to put in masks which we did and were able to establish communication. I [advised ATC] stating we had lost cabin pressure.Due to traffic below us we were initially cleared to FL350 and turned left 30 degrees. I used FLCH and spoilers; however not all spoilers deployed and we got a spoiler EICAS. The Captain called the other pilot and purser to the cockpit. We got clearance to FL290; then down to 10;000 ft. While descending at 340 kts. and spoilers out; several more EICAS messages appeared. The Captain briefed the purser and First Officer we were in an [expedited descent] and prepare for masks to deploy. ATC asked where we needed to go; Captain said ZZZZ for now. He ran whatever checklist popped up; it was difficult to see with the masks on due to the high cockpit temperatures which fogged up the inside of the masks.The Captain told the other First Officer to deploy the masks if the cabin got to 10;000 ft. which it did passing about 13;000 ft. Level at 10;000 ft.; I said masks off. We evaluated the situation; no packs and in a degraded electrical mode. We decided to head towards ZZZZ1 instead since ZZZZ from previous experience is not a good place to land. The First Officer called Dispatch and Maintenance Control on the Satcom. I flew and communicated with ATC; they were great; very professional and helpful. Maintenance said they could see what the problems were and in concurrence with the Captain and Dispatch we decided to go to ZZZ1 since we had plenty of fuel. I was not listening to their conversation so don't know the details. We headed towards ZZZ1 while continuing the conversation on Satcom; at this point the Chief Pilot joined the conversation.EICAS messages kept popping up with more failures. Due to the very high cabin and cockpit temperatures we ran the hot cabin checklist which seemed to help a bit. After about an hour we got E and E fan failure EICAS messages and several other fan and cooling failures.  Being uncomfortable to continue to ZZZ1 in an all-electric airplane; we came to the agreement to land in ZZZ2; about 30 minutes away. We headed straight for the outer maker for the ILS XX. Other EICAS messages concerning anti ice equipment made me descend to below the freezing level. I briefed a Cat 1 ILS to XX; weather for 400/1. Unable to auto land due to failures. Stab Trim R also appeared and the Captain said if I was unable to hand trim to give him the airplane in a timely manner. We broke out at minimums and made an uneventful landing and were met by emergency equipment and a follow me truck. Parked at the gate and left the flaps down per the spoiler checklist. We debriefed and called Maintenance Control and Dispatch.


Synopsis: B787 flight crew reported multiple pressurization and electrical failures in cruise that resulted in a diversion.