Date: 202003
Local time of day: 0601-1200
Location: ZZZ.ARTCC, US
Flight conditions: IMC
Light: Daylight
Aircraft: Small Transport; Low Wing; 2 Turbojet Eng
Operator: Fractional
Operating under: Part 135
Flight plan: IFR
Mission: Passenger
Flight phase: Cruise
Airspace: Class A ZZZ
ATC / advisory: Center ZZZ
Reporter organization: Fractional
Reporter function: Captain; Pilot Flying
Reporter qualification: Flight Crew Air Transport Pilot (ATP); Flight Crew Instrument; Flight Crew Multiengine
Human factors: Situational Awareness; Distraction; Communication Breakdown; Confusion
Second reporter function: Pilot Not Flying; Captain
Anomaly: ATC Issue All Types; Deviation - Track / Heading All Types; Deviation / Discrepancy - Procedural Clearance; Deviation / Discrepancy - Procedural Published Material / Policy; Inflight Event / Encounter Fuel Issue
Detector: Person Flight Crew
When detected: In-flight
Result: General None Reported / Taken
Contributing factors: Environment - Non Weather Related; Company Policy; Airspace Structure; Human Factors; Procedure
Primary problem: Environment - Non Weather Related

Narrative: Classic Swiss Cheese event. We were scheduled out of ZZZ1 repo to ZZZ2 to pick up pax to ZZZ3. We called ZZZ2; and determined the FBO facility was closed; but services were available. With that in mind we printed up both releases as both were available and downloaded both into the Garmin; reviewing both. The ZZZ3 was standard routing which kept us well clear of the weather system inbound from the west. At some point shortly before we departed ZZZ1; we received an updated release for the ZZZ3 flight which showed an increase in fuel; which we wrongly assumed was due to the approaching weather; and also necessitated fueling in ZZZ2; rather than being fueled through. What we totally missed was the route change after ZZZ4; off the STAR  routing and into the weather system; routing via ZZZ5 and through ZZZ6 terminal area. The routing change was due to ZZZ7 Center being shutdown due to a positive Corona virus test. There was a missed opportunity somewhere in the cheese process in hindsight . We were wrong not to look further than the fuel load change. Dispatch could have sent an email highlighting the reason for the change. The change reasons were annotated on the cover page of the release; which we did not have because we had the previous hard copy on board and had modified the weights and updated the performance numbers there. Enroute with pax; shortly after passing ZZZ4; ATC queried our routing and we were able to correct to the updated route via ZZZ5; instead of the airway to ZZZ8. ATC was able to provide the information on the closed airspace ahead; of which we were previously unaware.We were wrong not to look further than the fuel load for the change  A call from dispatch; or an email highlighting the virus related reroute; would have better reset our plan; and we could have briefed the owners upon boarding; rather than enroute when we became aware of the airspace closure.                             The first ZZZ2 ZZZ3 plan was completed at XA:04; the second at XB:48. Had it not been for the virus associated operational considerations we would probably not have printed up the early release; and printed up; what would have been the later one; at ZZZ2 as normal. Lotsa coulda wouldas; but WE missed the change.


Second narrative: Navigation deviation occurred upon crossing ZZZ4 northbound.  ATC queried us about the route saying they showed us off course.  As the PM; I responded negative and with flight release paperwork in hand; I began to respond with our filed/cleared route; but the PIC let me know that we had a problem.  He quickly realized the error.  He had printed off the paperwork for the first flight release and that is what we were operating the flight based on.  Unfortunately our Dispatch had issued a subsequent flight release increasing our fuel load by 1;000 pounds...this we were aware of and had uploaded the proper amount of fuel at ZZZ2.  Unfortunately; Dispatch also changed the route after ZZZ4.  This we were unaware of.  The original flight release is what we loaded in the box; verified together and this is what we flew when given cleared as filed.  When Center advised us of the deviation; we obtained the new clearance; loaded it into the FMS and continued to our destination with no further incidents.Though it is dual release type of operation between Dispatch and Crew; when Dispatch updates the flight plan; after having issued a flight release; it would be super helpful and considerate if they would reach out to the Crew regarding the changes...especially any changes to the route.  When the Crew receives an updated flight release; it is imperative that we review it and abide by pertinent changes.  As the FO; I will be more aggressive in backing up the PIC when I see changes of this nature occurring...less trusting if you will and not just assuming that all is well because the PIC said so.


Synopsis: Pilots reported routing and fuel problems associated with a ARTCC airspace closure.