0ff7571a-b33e-40b6-8dfa-28fb8d5f8183.json

{
 "id": "0ff7571a-b33e-40b6-8dfa-28fb8d5f8183",
 "disease": {
  "id": "H00031",
  "names": [
   "Breast cancer"
  ],
  "dbLinks": {
   "icd10": [
    "C50"
   ],
   "mesh": [
    "D001943"
   ]
  },
  "category": "Cancer"
 },
 "article": {
  "id": "25692500",
  "text": "BACKGROUND:\nThe influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk.\n\nOBJECTIVE:\nTo conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality.\n\nDESIGN:\nMEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast-cancer-specific death was evaluated by combining multivariable adjusted estimates comparing highest versus lowest categories of intake; and per 20 g increase in intake of total and/or saturated fat (g/day) using random-effects meta-analyses.\n\nRESULTS:\nFifteen prospective cohort studies investigating total fat and/or saturated fat intake (g/day) and breast cancer mortality were included. There was no difference in risk of breast-cancer-specific death (n = 6; HR = 1.14; 95% CI: 0.86, 1.52; p = 0.34) or all-cause death (n = 4; HR = 1.73; 95% CI: 0.82, 3.66; p = 0.15) for women in the highest versus lowest category of total fat intake. Breast-cancer-specific death (n = 4; HR = 1.51; 95% CI: 1.09, 2.09; p \u003c 0.01) was higher for women in the highest versus lowest category of saturated fat intake.\n\nCONCLUSIONS:\nThese meta-analyses have shown that saturated fat intake negatively impacts upon breast cancer survival."
 },
 "questions": [
  {
   "id": "14baabaa-5099-456b-89cd-0fa69564a906",
   "text": "What are the risk factors of Breast Cancer?",
   "answers": [
    {
     "answer_start": 1271,
     "text": "saturated fat intake"
    }
   ]
  }
 ]
}