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- ---
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- license: mit
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- ---
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- # Dataset Description
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- ## Dataset Summary
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- This dataset was parsed from the Human-HIV Interaction dataset maintained by the NCBI.
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- It contains a >16,000 pairs of interactions between HIV and Human proteins.
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- Sequences of the interacting proteins were retrieved from the NCBI protein database and added to the dataset.
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- The raw data is available from the [NBCI FTP site](https://ftp.ncbi.nlm.nih.gov/gene/GeneRIF/hiv_interactions.gz) and the curation strategy is described in the [NAR Research paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383939/) announcing the dataset.
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- ## Dataset Structure
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- ### Data Instances
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- Data Fields: hiv_protein_product, hiv_protein_name, interaction_type, human_protein_product, human_protein_name, reference_list, description, hiv_protein_sequence, human_protein_sequence
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- Data Splits: None
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- ## Dataset Creation
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- Curation Rationale: This dataset was curated train models to recognize proteins that interact with HIV.
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- Initial Data Collection and Normalization: Dataset was downloaded and curated on 4/4/2022 but the most recent update of the underlying NCBI database was 2016.
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- ## Considerations for Using the Data
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- Discussion of Biases: This dataset of protein interactions was manually curated by experts utilizing published scientific literature.
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- This inherently biases the collection to well-studied proteins and known interactions.
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- The dataset does not contain _negative_ interactions.
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- ## Additional Information:
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- - Dataset Curators: Will Dampier
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- - Citation Information: TBA