Complex sentence: Vaughan had sent a number of settlers in 1617 and had intentions of making the maiden voyage and settling in his new colony but because of ill health Vaughan was not able to do so.
Split into simpler sentences: Vaughan had sent a number of settlers in 1617 with every good intention of making the maiden voyage himself and settling in his new colony with them. Because of ill health, Vaughan was not able to do so.