Complex sentence: Without Shocker's aid to manage his body, the effects on Ichimonji had became more life threatening and debilitating by time the returns to support Hongou and insists on aiding him in spite of his condition.
Split into simpler sentences: Without Shocker's aid to manage his body, the effects on Ichimonji had became more life threatening and debilitating. By the time he returns to support Hongo, he insists on aiding him in spite of his condition.