Complex sentence: The Colima Cartel is a Mexican drug trafficking and methamphetamine producing cartel operating out of Guadalajara, Jalisco, and formerly lead by José de Jesús Amezcua Contreras while and supported by his brothers Adán and Luis.
Split into simpler sentences: The Colima Cartel is a Mexican drug trafficking and methamphetamine producing cartel operating out of Guadalajara, Jalisco, and formerly led by the Amezcua Contreras brothers. The cartel was directed by José de Jesús Amezcua Contreras, and supported by his brothers, Adán and Luis.