Complex sentence: Though the exact mechanism of how loss of aspartoacylase activity leads to Canavan disease is not fully understood, there are two primary competing explanations.The first is that it leads to defective myelin synthesis due to a deficiency of acetyl CoA derived from the acetate product.
Split into simpler sentences: Though the exact mechanism of how loss of aspartoacylase activity leads to Canavan disease is not fully understood, there are two primary competing explanations. One is that it leads to defective myelin synthesis due to a deficiency of acetyl CoA derived from the acetate product.