Complex sentence: Fox is best known for writing and illustrating the "Toonerville Folks" comic panel that appeared from 1913 to 1955 in 250 to 300 newspapers across North America.
Split into simpler sentences: Fox is best known for writing and illustrating his "Toonerville Folks" comic panel. It ran from 1913 to 1955 in 250 to 300 newspapers across North America.