Complex sentence: It is a Yamanaka factor (along with three others transcription factors: Oct4, Sox2 and Klf4), though it has since been possible to generate iPS without c-MYC.
Split into simpler sentences: It is a Yamanaka factor (along with three others transcription factors: Oct4, Sox2 and Klf4). Even though it has since been possible to generate iPS without c-MYC.