Complex sentence: The university is approximately five miles (8 km) east of downtown Cleveland in the neighborhood known as University Circle, a 550-acre (220 ha) area containing numerous other educational, medical, and cultural institutions.
Split into simpler sentences: The university is approximately five miles (8 km) east of downtown Cleveland in University Circle. It is contained within a 550-acre (220 ha) area containing numerous educational, medical, and cultural institutions.