Complex sentence: It may however be unreliable in patients with calcified arteries in the calf (often diabetic patients) or those with extensive oedema, in which case toe pressure or Toe-brachial pressure index (TBPI) should be measured to aid in the diagnosis.
Split into simpler sentences: It may however be unreliable in patients with calcified arteries in the calf (often diabetic patients) or those with extensive oedema. In which case Toe-brachial pressure index (TBPI) should be performed to aid in the diagnosis.