Complex sentence: One of Smale's theorems is that when one deals with knots in co-dimension greater than two, even inequivalent knots have diffeomorphic complements, giving the subject a different flavour than co-dimension 2 knot theory.
Split into simpler sentences: One of Smale's theorems is that when one deals with knots in co-dimension greater than two, even inequivalent knots have diffeomorphic complements. This gives the subject a different flavour than co-dimension 2 knot theory.