Complex sentence: There is siginificant up-regulation of the apoptotic cascade by the parasite, and, furthermore, substantial down-regulation of the anti-apoptotic proteins Bcl-2 and upregulation of the proapoptotic protein Bax.
Split into simpler sentences: There is siginificant up-regulation of the apoptotic cascade by the parasite. Furthermore, substantial down regulation of the anti-apoptotic proteins Bcl-2 and upregulation of the proapoptotic protein Bax.