Complex sentence: After oral administration, ebastine undergoes extensive first-pass metabolism by hepatic cytochrome P450 3A4 into its active carboxylic acid metabolite, carebastine.
Split into simpler sentences: After oral administration, ebastine undergoes an extensive first-pass. Metabolismo by cytochrome P450 3A4 into its active carboxylic acid matabolite, carebastine.