Complex sentence: Linaclotide is a peptide agonist mimic of endogenous guanylin and uroguanylin, both of which activate the cell surface receptor of guanylate cyclase 2C (GC-C).
Split into simpler sentences: Linaclotide is a peptide mimic of endogenous guanylin and uroguanylin. Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C).