Complex sentence: Almost all major streets that go east to west, are avenues, and almost all streets going north to south, are streets, with the exception of Sanderson Avenue, Lyon Avenue, Palm Ave and Cawston Avenue.
Split into simpler sentences: Almost all major streets that go east-west are avenues, and almost all streets going north-south are streets. Exceptions are Sanderson Avenue, Lyon Avenue, Palm Ave and Cawston Avenue.