Complex sentence: Sanfilippo syndrome, or Mucopolysaccharidosis III (MPS-III) is a rare autosomal recessive lysosomal storage disease caused by a deficiency in one of the enzymes needed to breakdown the glycosaminoglycan heparan sulfate (which is found in the extra-cellular matrix and on cell surface glycoproteins).
Split into simpler sentences: Sanfilippo syndrome, or Mucopolysaccharidosis III (MPS-III) is a rare genetic disease. This lysosomal storage disorders is due to deficiency in one of the enzymes needed to breakdown the glycosaminoglycan heparan sulfate (which is found in the extra-cellular matrix and on cell surface glycoproteins).