Complex sentence: Despite a briefly successful return to mainstream thanks to the popularity of "Scream", the genre again declined in the early-2000s, where mainstream success was found in remakes and throwbacks to the genre's prime.
Split into simpler sentences: Despite a briefly successful return to mainstream thanks to the popularity of "Scream", the genre again declined in the early-2000s. Mainstream success for slasher films was thereafter found in remakes and throwbacks to the genre's prime.