Complex sentence: The Giants allowed 51 points, the most points allowed at home since 1964, and lost to the Rams for the first time since 2001 and suffered their first home loss to the Rams since 2000.
Split into simpler sentences: The Giants allowed 51 points, the most points allowed at home since 1964. This was the first loss to the Rams since 2001 and their first home loss to the Rams since 2000.