Complex sentence: Interestingly, deletions at the PLP1 locus cause a milder form of PMD than is observed with the typical duplication mutations, which demonstrates the critical importance of gene dosage at this locus for normal CNS function.
Split into simpler sentences: Interestingly, deletions at the PLP1 locus cause a milder form of PMD than is observed with the typical duplication mutations. This demonstrates the critical importance of gene dosage at this locus for normal CNS function.