Complex sentence: This leads to further increased plasma renin concentrations (PRC) and renin plasma activity (PRA) which can be problematic for ACE inhibitor and ARB therapy since increased PRA could partially overcome the pharmacologic inhibition of the RAAS cascade.
Split into simpler sentences: This leads to further increased plasma renin concentrations (PRC) and renin plasma activity (PRA). This can be problematic for ACE inhibitor and ARB therapy since increased PRA could partially overcome the pharmacologic inhibition of the RAAS cascade.