Complex sentence: As a result initially there is an increase in FSH and LH secretion (so-called flare effect), however after about ten days a profound hypogonadal effect is achieved through receptor downregulation.
Split into simpler sentences: As a result initially there is an increase in FSH and LH secretion (so-called "flare effect"). However after about ten days a profound hypogonadal effect is achieved through receptor downregulation.