Complex sentence: Studies demonstrating the effects of IMTGs have shown that the mechanism involves the activation of the protein kinase C theta, which promotes the phosphorylation of IRS-1, thereby inhibiting the insulin signaling cascade.
Split into simpler sentences: Studies demonstrating the effects of IMTGs, have shown that the mechanism involves the activation of the protein kinase C theta. Protein kinase C theta promotes the phosphorylation of IRS-1, thereby inhibiting the insulin signaling cascade.