Complex sentence: López-Bigas' lab has contributed to the identification of cancer driver genes by developing computational methodologies to detect signals of positive selection in the pattern of somatic mutations observed in tumors.
Split into simpler sentences: López-Bigas' lab has contributed to the identification of genes that drive abnormal growth of malignant cells, known as cancer driver genes. Her lab has developed computational methodologies to detect these signals of positive selection in the pattern of somatic mutations observed in tumors.