Complex sentence: Amenhotep III was the father of two sons with his Great Royal Wife Tiye through her first son, Crown Prince Thutmose, who predeceased his father, and her second son, Amenhotep IV, later known as Akhenaten, who ultimately succeeded Amenhotep III to the throne.
Split into simpler sentences: Amenhotep III was the father of two sons with his Great Royal Wife Tiye. Their first son, Crown Prince Thutmose, predeceased his father and their second son, Amenhotep IV, later known as Akhenaten, ultimately succeeded Amenhotep III to the throne.