Complex sentence: Loop diuretics act on the Na +-K + -2Cl-symporter (cotransporter) in the thick ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption this is achevied by competing for the Cl-binding site.
Split into simpler sentences: Loop diuretics act on the Na +-K + -2Cl-symporter (cotransporter) in the thick ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption. This is achevied by competing for the Cl-binding site.