Complex sentence: Ticlopidine, clopidogrel and prasugrel (Efient) are all thienopyridines and irreversible P2Y 12 inhibitors that have in common that they are all prodrugs which need to be altered to an active metabolite in-vivo to inhibit the P2Y 12 receptor.
Split into simpler sentences: Ticlopidine, clopidogrel and prasugrel (Efient) are all thienopyridines that cause irreversible inhibition of P2Y 12 inhibitors. They are all prodrugs which need to be converted to an active metabolite in-vivo to inhibit the P2Y 12 receptor.