Complex sentence: Antifungal drugs are the first line of defense to kill the agents causing phaeohyphomycosis, but despite the significant progress made in the last two decades and a 30% increase in available antifungal drugs since 2000, many drugs are not effective against black fungi.
Split into simpler sentences: Antifungal drugs are the first line of defense to kill the agents causing phaeohyphomycosis. But despite the significant progress made in the last two decades and a 30% increase of available antifungal drugs since 2000, many drugs are not effective against black fungi.