Complex sentence: The 100 block, the closest to the Ohio River, has seen the most demolition, still has the Old Strauss Hotel at the corner of Riverside Drive, a three-story Italianate hostelry with a corbeled cornice and arched windows.
Split into simpler sentences: The 100 block is the closest to the Ohio River and has seen the most demolition. It contains the Old Strauss Hotel at the corner of Riverside Drive, a three-story Italianate hostelry with a corbeled cornice and arched windows.