Complex sentence: It caused significant damage and a number of deaths throughout the region, and was known as the "Great San Francisco Earthquake" prior to the 1906 San Francisco earthquake and fire, and was the last large earthquake to occur on the Hayward Fault Zone.
Split into simpler sentences: It caused significant damage and a number of deaths throughout the region, and was known as the "Great San Francisco Earthquake" prior to the 1906 San Francisco earthquake and fire. It was the last large earthquake to occur on the Hayward Fault Zone.