Complex sentence: Many Native Americans suffered from exposure, disease, and starvation while going on the route to their destinations, many died, around 2,000-6,000 of the 16,543 relocated Cherokee.
Split into simpler sentences: Many Native Americans suffered from exposure, disease, and starvation while going on the route to their destinations. Many died, including around 2,000-6,000 of the 16,543 relocated Cherokee.