Complex sentence: Chalon-sur-Saône is part of the Burgundy region, it was once a well known river port, as a point to distribute local wines up and down the Saône river.
Split into simpler sentences: Chalon-sur-Saône is part of the Burgundy region. It is located on the Saône river, and was once a well known river port, as a point to distribute local wines up and down the Saône river.