Complex sentence: He died, without issue, at the siege of Bergen-op-Zoom in 1747, and was succeeded by his uncle John, son of James, first duke, by his second wife, who died, also without issue, in 1757.
Split into simpler sentences: He died, without issue, at the siege of Bergen-op-Zoom in 1747. He was succeeded by his uncle John, son of James, first duke, by his second wife, who died, also without issue, in 1757.