Complex sentence: Born in Washington, D.C., her career took her through all the acting mediums of the 20th century, spanning eight decades, and led her from Washington D.C. to New York City to Hollywood.
Split into simpler sentences: Born in Washington, D.C., her career would span take her through all the acting mediums of the 20th century, spanning eight decades. Her career would take her from Washington D.C. to New York City to Hollywood.