Complex sentence: The syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-β).
Split into simpler sentences: The syndrome is caused by the misfolding of fibrillin-1, a protein which forms fibers in connective tissue. It also contributes to cell signaling activity, binding to transforming growth factor beta (TGF-β).