Complex sentence: Courvoisier's sign defines the presence of jaundice and a painlessly distended gallbladder as strongly indicative of pancreatic cancer, and may be used to distinguish pancreatic cancer from gallstones.
Split into simpler sentences: Courvoisier's sign is the presence of jaundice with a painlessly swollen gallbladder and is strongly indicative of pancreatic cancer. It can be used to distinguish pancreatic cancer from gallstones.