Complex sentence: The JR Yokosuka Line passes directly under the building, which is flanked by the Yurikamome New Transit line on the west and south sides, and the Shuto Expressway on the east.
Split into simpler sentences: The JR Yokosuka Line passes directly under the building. The building is surrounded by the Yurikamome New Transit line on the west and south sides, and the Shuto Expressway on the east.