Complex sentence: No Vice President had ever sought more than two terms in office, and such a move would raise controversy, and a challenge by opponents would probably have to be decided by the Supreme Court, on the relevance of the 22nd Amendment to the Vice Presidency.
Split into simpler sentences: No Vice President had ever sought more than two terms in office, and such a move would most likely raise controversy. A challenge by opponents would probably have to be decided by the Supreme Court, on the relevance of the 22nd Amendment to the Vice Presidency.