Complex sentence: Based on the X-ray structure analysis, when the open structure is applied, the axes of the TIM barrel and Rossmann domains are in different directions and with the addition of the substrate, the subunits rearrange to turn the axes into each other to facilitate the catalysis.
Split into simpler sentences: Based on the X-ray structure analysis, when open structure is applied, the axes of the TIM barrel and Rossmann domains are in different directions. And with the addition of the substrate, the subunits rearrange to turn the axes into each other to facilitate the catalysis.