Complex sentence: Manchester City Centre, the location of most of Manchester's tallest buildings and structures, is a regional central business district, at the centre of the wider Greater Manchester Urban Area which has a population of 2,240,230.
Split into simpler sentences: Manchester City Centre, the location of most of Manchester's tallest buildings and structures, is a regional central business district. It is at the centre of the wider Greater Manchester Urban Area which has a population of 2,240,230.