Complex sentence: They are produced from proopiomelanocortin (POMC) in the anterior pituitary gland and they exert their effects by binding to and activating the melanocortin receptors.
Split into simpler sentences: They are produced from proopiomelanocortin (POMC) in the anterior pituitary gland. They exert their effects by binding to and activating the melanocortin receptors.