Complex sentence: Wilkes married Elizabeth Wood from Burton upon Trent in 1759 and together they had many children, and although unfortunately his only son didn't survive past infancy, some of his daughters however, did grow up and were married.
Split into simpler sentences: Wilkes married Elizabeth Wood from Burton upon Trent in 1759. Although his only son did not survive past infancy, some of his daughters did grow up and were married.