Complex sentence: Kentucky Wesleyan, with its eight national basketball titles, is the biggest loss for the GLVC, but, with only 680 students, the school had trouble competing in the other sports against much larger schools.
Split into simpler sentences: Kentucky Wesleyan, with its eight national basketball titles, is the biggest loss for the GLVC. But, with only 680 students, the school had trouble competing in the other sports against much larger schools.