Complex sentence: The Donald laboratory designed peptide inhibitors of a protein-protein interaction involved in cystic-fibrosis, with potential therapeutic applications; these inhibitors formed a beta-sheet with the pdz-binding domain of the inhibited protein.
Split into simpler sentences: The Donald laboratory designed peptide inhibitors of a protein-protein interaction involved in cystic-fibrosis. These inhibitors formed a beta-sheet in the pdz-binding domain of the inhibited protein.