Complex sentence: Because EHDV is a double-stranded RNA virus, it needs to overcome a specific set of problems, the main one being the fact that double-stranded RNA are unable to be used as template strand during mRNA translation using host cell machinery.
Split into simpler sentences: Because EHDV is a double-stranded RNA virus, it needs to overcome a specific set of problems. The main one being the fact that double-stranded RNA are unable to be used as template strand during mRNA translation using host cell machinery.