Complex sentence: Depp began her acting career with a cameo role in "Tusk" when she was asked by Kevin Smith, the father of her friend Harley Quinn Smith if she would enjoy acting with her friend and father.
Split into simpler sentences: Depp began her acting career with a cameo role in Tusk'. She was asked by Kevin Smith, the father of her friend Harley Quinn Smith if she would enjoy acting with her friend and father.