Complex sentence: Chaperones exist in all cellular compartments and interact with the polypeptide chain in order to allow the native three-dimensional conformation of the protein to form; however, chaperones themselves are not included in the final structure of the protein they are assisting in.
Split into simpler sentences: Chaperones exist in all cellular compartments and interact with the polypeptide chain in order to allow the native three dimensional conformation of the protein to form. However, chaperones themselves are not included in the final structure of the protein they are assisting in.