Complex sentence: The main attraction of Loreto is, however, the Holy House itself (in Italian, the "Santa Casa di Loreto"), a Catholic place of pilgrimage since at least the 14th century and a popular tourist destination for non-Catholics as well.
Split into simpler sentences: The main attraction of Loreto is the Holy House itself (in Italian, the "Santa Casa di Loreto"). It has been a Catholic pilgrimage destination since at least the 14th century and a popular tourist destination for non-Catholics as well.