Complex sentence: Many of Zelda's friends and members of her family were wary of the relationship, however, as they did not approve of Scott's excessive drinking, and Zelda's Episcopalian family did not like the fact that he was a Catholic.
Split into simpler sentences: Many of Zelda's friends and members of her family were wary of the relationship. They did not approve of Scott's excessive drinking, and her Episcopalian family did not like that he was a Catholic.