Complex sentence: Effects of European infectious diseases and conquest, and assimilation by larger native tribes, led to native abandonment of the settlement long before English explorers arrived in the region in the 17th century, followed by Scots-Irish and German immigrants in the 18th century.
Split into simpler sentences: Effects of European infectious diseases and conquest, and assimilation by larger native tribes, led to native abandonment of the settlement long before English explorers arrived in the region in the 17th century. They were followed by English, Scots-Irish and German immigrants in the 18th century.