Complex sentence: He was descended from Nathaniel Tilden, an early English settler who came to America in 1634, and his father and other family members were the makers of Tilden's Extract, a popular patent medicine of the 1800s and early 1900s derived from cannabis.
Split into simpler sentences: He was descended from Nathaniel Tilden, an early English settler who came to America in 1634. His father and other family members were the makers of Tilden's Extract, a popular patent medicine of the 1800s and early 1900s derived from cannabis.