Complex sentence: The charity was founded in 2005 in response to disquiet about the uninformed opinion regarding the scientific value of animal studies (research involving laboratory animal experiments), and'a dissatisfaction with the polarised positions (taken) in the debate about animal research'.
Split into simpler sentences: The charity was constituted in 2005 in response to a disquiet about the uninformed opinion surrounding the scientific value of research involving laboratory animal experiments. It says there is'a dissatisfaction with the polarised positions (taken) in the debate about animal research'.