Complex sentence: Smith was born in Charleston, South Carolina; he started traveling with Medicine Shows when young and went into Vaudeville where he performed in an acts with Elmer Bowman and Jimmie Durante.
Split into simpler sentences: Smith was born in Charleston, South Carolina. He started traveling with Medicine Shows at a young age, then went into Vaudeville where he performed in an acts with Elmer Bowman and Jimmie Durante.