Complex sentence: The majority of treatable/treated cancers are of Gleason scores 5-7 and are detected due to biopsy after abnormal DRE/PSA and located in the peripheral zone usually the posterior portion explaining the rationale of performing the digital rectal exam.
Split into simpler sentences: The majority of treatable/treated cancers are of Gleason scores 5-7 and are detected due to biopsy after abnormal digital rectal exam or prostate specific antigen evaluation. The cancer is typically located in the peripheral zone usually the posterior portion, explaining the rationale of performing the digital rectal exam.