Complex sentence: Ishi Wilderness Area is in the southern Cascade foothills, approximately twenty miles east of Red Bluff, California, and lies the Ishi Wilderness, a unique 41,000 acre, low-elevation wilderness.
Split into simpler sentences: Ishi Wilderness Area, the southern Cascade foothills, is approximately twenty miles east of Red Bluff, California. It is within the Ishi Wilderness, a unique 41,000 acre, low-elevation wilderness.