Complex sentence: Individuals with Rabson-Mendenall syndrome will need ways to compensate for their insulin resistance, and may do this by increasing insulin secretion, which can lead to excessive insulin levels in the blood (hyperinsulinemia), which, in turn, is responsible for multiple symptoms.
Split into simpler sentences: Individuals with Rabson-Mendenall syndrome will need ways to compensate for their insulin resistance, and may do this by increasing insulin secretion. This can lead to excessive insulin levels in the blood (hyperinsulinemia), which, in turn, is responsible for multiple symptoms.