Complex sentence: This is the general strategy used for designing exon-skipping oligonucleotides for DMD; as there are 79 exons in the longest splice form of the dystrophin transcript, many different oligos are needed to address the range of mutations present in the population of people with DMD.
Split into simpler sentences: This is the general strategy used in the design of exon-skipping oligonucleotides for DMD. As there are 79 exons in the longest splice form of the dystrophin transcript, many different oligonucleotides are needed to address the range of mutations present in the population of people with DMD.