Complex sentence: He was born in Liverpool but came, at an early age, to Manchester with his father, Emmanuel Mendel, had a rope, twine, and pitch-paper business and established a hotel, the Manchester and Liverpool, subsequently known as Mendel's Hotel.
Split into simpler sentences: He was born in Liverpool, but at an early age moved to Manchester with his father, Emmanuel Mendel. Emmanuel had a rope, twine, and pitch-paper business and established a hotel, the Manchester and Liverpool, subsequently known as Mendel's Hotel.