Complex sentence: Born and raised in St. Louis, Holmes'family still lives there--his parents Charles and Mary Lou and two older brothers, Dan and Steve, who work in the family's financial-consulting business in Clayton, Missouri, a St. Louis suburb.
Split into simpler sentences: Born and raised in St. Louis, Holmes' family includes parents Charles and Mary Lou; and two older brothers, Dan and Steve. The family runs a financial consulting business in Clayton, Missouri, a St. Louis suburb.