Complex sentence: Her second film "Desperately Seeking Susan", featuring then-rising star Madonna, was a major box-office success for Seidelman, and launched the film careers of co-stars Rosanna Arquette and Aidan Quinn.
Split into simpler sentences: Her second film "Desperately Seeking Susan", featuring then-rising star Madonna was a major box-office success for Seidelman. It also launched the film careers of co-stars Rosanna Arquette and Aidan Quinn.