Complex sentence: The mutations that cause Noonan syndrome thus appear to perturb intramolecular interactions necessary for SOS1 auto-inhibition resulting in the production of hyper-activate and dysregulated variants of the protein.
Split into simpler sentences: The mutations that cause Noonan syndrome thus appear to perturb intramolecular interactions necessary for SOS1 auto-inhibition. In this way these mutations are thought to create SOS1 alleles encoding hyper-activated and dysregulated variants of the protein.