Complex sentence: The mechanism by which these genetic mutations cause pancreatitis is incompletely understood but is likely to be the result of increased autoactivation or reduced deactivation of trypsinogen (or a combination of the two), although a novel mechanism has recently been identified in a p.R116C kindred.
Split into simpler sentences: The mechanism by which these genetic mutations cause pancreatitis is not yet known; but is likely to be the result of increased autoactivation or reduced deactivation of trypsinogen. However, a novel mechanism has recently been identified in a p.R116C kindred.