Complex sentence: The energetics of DNA tertiary structure assembly were determined to be primarily driven by the hydrophobic effect, as opposed to Watson-Crick base pairing (which is responsible for sequence selectivity), although there is also a significant contribution from stacking interactions between the aromatic bases.
Split into simpler sentences: The energetics of DNA tertiary structure assembly were determined to be primaraly driven by the hydrophobic effect, as opposed to Watson-crick base pairing which are responsible for sequence selectivity. Although there is also a significant contribution from stacking interactions between the aromatic bases.