Complex sentence: The three VDAC isoforms (VDAC1, VDAC2, and VDAC3) have highly conserved DNA sequences as well as 3D structures forming a wide β-barrel structure, inside of which the alpha helical N-terminal segment resides to partially close the pore.
Split into simpler sentences: The three VDAC isoforms (VDAC1, VDAC2, and VDAC3) have highly conserved DNA sequences as well as 3D structure. VDACs form a wide β-barrel structure, inside of which the alpha helical N-terminal segment resides to partially close the pore.