Complex sentence: The main performance gain is due to a heuristic filter that finds high-scoring un-gapped matches within database sequences to a query profile, this heuristic results in a computation time comparable to BLAST with little impact on accuracy.
Split into simpler sentences: The main performance gain is due to a heuristic filter that finds high-scoring un-gapped matches within database sequences to a query profile. This heuristic results in a computation time comparable to BLAST with little impact on accuracy.