Complex sentence: The route starts at Chicago and runs west across northern Illinois to the Mississippi River; it follows the eastern shore of the river through La Crosse and Prairie du Chien, Wisconsin before turning west again in Minneapolis and St. Paul, Minnesota to Dilworth, Minnesota.
Split into simpler sentences: The route starts at Chicago and runs west across northern Illinois to the Mississippi River. It follows the eastern shore of the river through La Crosse and Prairie du Chien, Wisconsin before turning west again in Minneapolis and St. Paul, Minnesota to Dilworth, Minnesota.