Complex sentence: Skeptics of this procedure argue there is no multi-centered randomized Phase 3 trial comparing CRS + HIPEC with systemic therapy or complete cytoreduction with systemic therapy, and hence not met the scientific bar to be considered standard of care.
Split into simpler sentences: Skeptics of this procedure argue there is no multi-centered randomized Phase 3 trial comparing CRS + HIPEC with complete cytoreduction followed by systemic therapy. Hence this therapy has not met the scientific bar to be considered standard of care.