Complex sentence: Insane Films is one of the earliest videoblogs ever created, originating sometime in 2000, but Madge Weinstein's fame grew largely from her indie podcast Yeast Radio, which began in late November 2004.
Split into simpler sentences: Insane Films is one of the earliest videoblogs ever created, originating sometime in 2000. However, Madge Weinstein's fame grew largely from her indie podcast Yeast Radio, which began in late November 2004.