Complex sentence: It is located north and east of the Chicago River, just north of the downtown central business district, (the Loop); to its east is Lake Michigan and its northern boundary is the 19th-century city limit of Chicago, North Avenue.
Split into simpler sentences: It is located north and east of the Chicago River, just north of the central business district (the Loop). To its east is Lake Michigan and its northern boundary is the 19th-century city limit of Chicago, North Avenue.