Complex sentence: This property of free heme can sensitize a variety of cell types to undergo programmed cell death in response to pro-inflammatory agonists, a deleterious effect that plays an important role in the pathogenesis of certain inflammatory diseases such as malaria.
Split into simpler sentences: This property of free heme can sensitize a variety of cell types to undergo programmed cell death in response to pro-inflammatory agonists. This deleterious effect is thought to play an important role in the pathogenesis of certain inflammatory diseases such as malaria.