Complex sentence: Glyceryl trinitrate (GTN) has been used to treat angina and heart failure since at least 1880, despite this the mechanism of nitric oxide (NO) generation from GTN and the metabolic consequences of this bioactivation are still not entirely understood.
Split into simpler sentences: Glyceryl trinitrate (GTN) has been used to treat angina and heart failure since at least 1880. Despite this, the mechanism of nitric oxide (NO) generation from GTN and the metabolic consequences of this bioactivation are still not entirely understood.