Complex sentence: Appointed Governor of Anatolia, in 1544 he became fourth Vizier, and was nominated lieutenant Governor of Istanbul during the Second campaign of the Ottoman-Safavid War in 1548-9, reaching the rank of third Vizier.
Split into simpler sentences: Appointed Governor of Anatolia, in 1544 he was nominated fourth Vizier. In 1548-9, during the Second campaign of the Ottoman-Safavid War, he got the position of lieutenant Governor of Istanbul reaching the rank of third Vizier.