Complex sentence: It has been hypothesized that the efficacy of glycine agonists entails the differential communication between the NR2 subtypes and the NR1 receptors, where the residues of the NR1 domain may interact differently with the NR2 subtypes, especially during instances of intra-protein conformational changes at the dimer interface.
Split into simpler sentences: It has been hypothesized that the efficacy of glycine agonists entails the differential communication between the NR2 subtypes and the NR1 receptors. This is due to the fact that residues of the NR1 domain may interact differently with the NR2 domain subtypes, especially during instances of intra-protein conformational changes at the dimer interface.