Complex sentence: Modern version of lipid hypothesis states that general anesthetic when solubilized in the bilayer causes a redistribution of membrane lateral pressures, which shifts the conformational equilibrium of certain membrane proteins known to be affected by clinical concentrations of anesthetics such as ligand-gated ion channels.
Split into simpler sentences: Modern version of lipid hypothesis states that anesthetic effect happens if solubilization of general anesthetic in the bilayer causes redistribution of membrane lateral pressures. Change in membrane lateral pressure profile shifts the conformational equilibrium of certain membrane proteins known to be affected by clinical concentrations of anesthetics such as ligand-gated ion channels.