Complex sentence: In normal cells cGAS is modified by K48-polyubiquitin chain, it goes to the p62 mediated autophagic degradation and the type I IFN signalling is suppressed.
Split into simpler sentences: In normal cells, cGAS is modified by the K48-polyubiquitin chain. It goes to the p62 mediated autophagic degradation and the type I IFN signalling is suppressed.