Complex sentence: Mechanical deformations in the cell membrane can increase the probability of the channels opening; proteins of the extracellular matrix and cytoskeleton are tethered to extra-and intra-cytoplasmic domains, respectively, of the stretch-activated ion channels.
Split into simpler sentences: Mechanical deformations in the cell membrane can increase the probability of the channels opening. Proteins of the extracellular matrix and cytoskeleton are tethered to extra-and intra-cytoplasmic domains, respectively, of the stretch-activated ion channels.