Complex sentence: Most of the surrounding neighborhood, one of the oldest in Mobile, was demolished to make way for the interstate project, the most notable section being the early multi-storied townhouses of Bloodgood's Row along Monroe Street.
Split into simpler sentences: Most of the surrounding neighborhood, one of the oldest in Mobile, was demolished to make way for the interstate project. The most notable section of the neighborhood that was destroyed was the early multi-storied townhouses of Bloodgood's Row along Monroe Street.