Complex sentence: Tomás Vélez Cachupín, despite tobacco law, was able to negotiate peace with the nomadic Native Americans at war, but, however, could not get along with the Franciscan friars.
Split into simpler sentences: Tomás Vélez Cachupín, despite a tobacco law, was able to negotiate peace with the nomadic Native Americans at war. However, he could not get along with the Franciscan friars.