Complex sentence: PML-NBs are not randomly distributed throughout the genome within the nucleus, commonly associated with other nuclear bodies such as splicing speckles and nucleoi, as well as regions that are rich in genes and are actively being transcribed.
Split into simpler sentences: PML-NBs are not randomly distributed throughout the genome. However, they are found within the nucleus and are commonly associated with other nuclear bodies such as splicing speckles and nucleoi, as well as regions that are rich in genes and are actively being transcribed.