Complex sentence: They devoted themselves to preaching and charitable work in Italy, as the Italian War of 1535-1538 renewed between Charles V, Holy Roman Emperor, Venice, the Pope and the Ottoman Empire rendered any journey to Jerusalem impossible.
Split into simpler sentences: They devoted themselves to preaching and charitable work in Italy. The Italian War of 1535-1538 renewed between Charles V, Holy Roman Emperor, Venice, the Pope, and the Ottoman Empire, had rendered any journey to Jerusalem impossible.