Complex sentence: In 2016, stress granule "cores" were biochemically purified for the first time and proteins were identified in an unbiased manner using mass spectroscopy, leading to the identification of hundreds of new stress granule-localized proteins.
Split into simpler sentences: In 2016, stress granule "cores" were biochemically purified for the first time and proteins in the cores were identified in an unbiased manner using mass spectroscopy. This technical advance lead to the identification of hundreds of new stress granule-localized proteins.