Complex sentence: Crist then opted instead to run with no party affiliation, and Rubio went on to win the Republican nomination, and won the general election in November 2010 with 49 percent of the vote.
Split into simpler sentences: Crist then opted instead to run with no party affiliation, and Rubio went on to win the Republican nomination. He won the general election in November 2010 with 49 percent of the vote.