Complex sentence: His other Pike's Opera House, in Cincinnati, burned in the Great Fire of Cincinnati, in 1866; rebuilt after the fire, and the first home of the Cincinnati Symphony Orchestra, it burned in 1903.
Split into simpler sentences: His other Pike's Opera House, in Cincinnati, burned in the Great Fire of Cincinnati, in 1866. Rebuilt after the fire, and the first home of the Cincinnati Symphony Orchestra, it burned again in 1903.