Complex sentence: While Peynaud's techniques were quite successful in the Médoc, they didn't always translate well in Pomerol which was not only working with a different grape but also with very different soil conditions that were much cooler (despite the overall warmer climate).
Split into simpler sentences: While Peynaud's techniques were largely successful in the Médoc, they did not always translate well to Pomerol. Not only was this region working with a different grape, but also with different soil conditions that were cooler (despite the overall warmer climate).