Complex sentence: The size of the TGF response is directly dependent upon these changes, in part because of the striking effect of deletion of A1 adenosine receptors (A1AR), adenosine generated from released ATP has been proposed as the critical TGF mediator.
Split into simpler sentences: The size of the TGF response is directly dependent upon these changes. In part because of the striking effect of deletion of A1 adenosine receptors (A1AR), adenosine generated from released ATP has been proposed as the critical TGF mediator.