Complex sentence: He left issue two sons, Edward and Dr. Nicholas Wotton, and three daughters, of whom Margaret (d.1541) was the second wife of Thomas Grey, 2nd Marquess of Dorset.
Split into simpler sentences: He left issue two sons, Edward and Dr. Nicholas Wotton, and three daughters. Edward's sister Margaret was the second wife of Thomas Grey, 2nd Marquess of Dorset.