Complex sentence: In certain brain regions, amphetamine increases the concentrations of dopamine in the synaptic cleft, thereby heightening the response of the post-synaptic neuron; through a-mediated mechanism, the firing rate of dopamine receptors decreases, preventing a hyper-dopaminergic state.
Split into simpler sentences: In certain brain regions, amphetamine increases the concentrations of dopamine in the synaptic cleft, thereby heightening the response of the post-synaptic neuron. Through a-mediated mechanism, the firing rate of dopamine receptors decreases, preventing a hyper-dopaminergic state.