Complex sentence: Venezia Santa Lucia is located in Cannaregio, the northernmost of the six historic "sestieri" (districts) of the historic city, near the western end of the Grand Canal.
Split into simpler sentences: Venezia Santa Lucia is located in Cannaregio district, the northernmost of the six historic "sestieri" (districts) of Venice's historic city. It is situated on the northernmost island and near the western end of the Grand Canal.