Complex sentence: A disadvantage of SSRIs is that they require continuous daily treatment to delay ejaculation significantly, and it is not clear how they affect psychological distress of those with the condition or the persons control over ejaculation timing.
Split into simpler sentences: A disadvantage of SSRIs is that they require continuous daily treatment to delay ejaculation significantly. And it is not clear how they affect psychological distress of those with the condition or the persons control over ejaculation timing.