Complex sentence: Eculizumab is a recombinant humanized monoclonal IgG 2/4 antibody that specifically binds to the complement protein C5, inhibiting its cleavage by the C5 convertase and thus preventing the generation of the terminal complement complex C5b-9 which causes intravascular hemolysis in people with (PNH).
Split into simpler sentences: Eculizumab is a recombinant humanized monoclonal IgG 2/4 antibody that specifically binds to the complement protein C5, inhibiting its cleavage by the C5 convertase which prevents the generation of the terminal complement complex C5b-9. It is this terminal complement complex that causes intravascular hemolysis in people with (PNH).