Complex sentence: Despite such setbacks, the new colony continued to grow, and soon settlers populated the area on a permanent basis, eventually driving out the Nansemond--the tribe lost their last known reservation lands in 1792.
Split into simpler sentences: Despite such setbacks, the new colony continued to grow, and soon settlers populated the area on a permanent basis. They gradually drove out the Nansemond--the tribe lost their last known reservation lands in 1792.