Complex sentence: Nicotine is unusual in comparison to most drugs, as its profile changes from stimulant to sedative with increasing dosages and use, a phenomenon known as "Nesbitt's paradox" after the doctor who first described it in 1969.
Split into simpler sentences: Nicotine is unusual in comparison to most drugs, as its profile changes from stimulant to sedative with increasing dosages. A phenomenon known as "Nesbitt's paradox" after the doctor who first described it in 1969.