Complex sentence: His drive to help people is disrupted as he discovers that the people surrounding him try to take advantage of his inexperience and in his effort to fight a syphilis epidemic he has to contend with the uneducated populace who refuse his treatment.
Split into simpler sentences: His drive to help people is disrupted because locals attempt to take advantage of his inexperience. In his effort to fight a syphilis epidemic he has to contend with the uneducated populace who refuse his treatment.