Complex sentence: The third tier knowledge hubs, in various urban areas throughout the state would have a university, autonomous college, as well as a medical and an engineering college, while the fourth tier would include towns with at least an autonomous college and trade school.
Split into simpler sentences: The third tier knowledge hubs, located in all urban areas throughout the state, would have a university, an autonomous college, as well as a medical and an engineering college. Lastly, the fourth tier would include smaller towns, which would have at least an autonomous college and a trade school.