Complex sentence: One of the major works that influenced "Native Son" was Harriet Beecher Stowe's "Uncle Tom's Cabin" (1852), the best-selling novel of the 19th century which also played a major role in the abolitionist movement.
Split into simpler sentences: One of the major works that influenced "Native Son" was Harriet Beecher Stowe's "Uncle Tom's Cabin". Published in 1852, "Uncle Tom's Cabin" was not only the best-selling novel of the century but also played a major role in the abolitionist movement.