Complex sentence: The "Portrait of Simonetta Vespucci" is a painting by the Italian Renaissance painter Piero di Cosimo, c.1480, which portrays noted Genoese beauty Simonetta Vespucci as Cleopatra with an asp around her neck.
Split into simpler sentences: The "Portrait of Simonetta Vespucci" is a painting by the Italian Renaissance painter Piero di Cosimo. Dating from c.1480, it portrays Genoese noblewoman Simonetta Vespucci as Cleopatra with an asp around her neck.