Complex sentence: The area was once inhabited by the Hohokams, a Native American tribe, and later by their descendants the Yavapai before the arrival and settlement of the people of Anglo European descent from the east coast of the United States.
Split into simpler sentences: The area was once inhabited by the Hohokams, a Native American tribe, and later by their descendants the Yavapai. This was before the arrival and settlement of the area by the people of Anglo European descent from the east coast of the United States.