Complex sentence: His wife Joan Wadham was the daughter of John Wadham of Merrifield, Somerset and sister of Nicholas Wadham they had four sons and two daughters, John, George, Nicholas, Edward, Ann and Elizabeth.
Split into simpler sentences: His wife Joan Wadham was the daughter of John Wadham of Merrifield, Somerset and sister of Nicholas Wadham. Together they had four sons and two daughters, John, George, Nicholas, Edward, Ann and Elizabeth.