Complex sentence: The first successful surgical use of Bioglass 45S5 was in replacement of ossicles in middle ear as a treatment of conductive hearing loss, and the material continues to be used in bone reconstruction applications today.
Split into simpler sentences: The first successful surgical use of Bioglass 45S5 was in replacement of ossicles in middle ear, as a treatment of conductive hearing loss. The material continues to be used in bone reconstruction applications today.