Complex sentence: Keap1 acts as a substrate adaptor protein for Cullin 3-based ubiquitination, which results in the proteasomal degradation of Nrf2, and under normal conditions Nrf2 has a half-life of only 20 minutes.
Split into simpler sentences: Keap1 acts as a substrate adaptor protein for Cullin 3-based ubiquitination. Under normal conditions Nrf2 has a half-life of only 20 minutes.