Complex sentence: Chromosomes size and structure varies between organisms, but, since DNA molecules are the reservoir of genetic information for all forms of life, many replication factors that solve these problems are highly conserved in terms of structure, chemistry, functionality, or sequence.
Split into simpler sentences: Chromosomes size and structure varies between organisms, but, since DNA molecules are the reservoir of genetic information for all forms of life, many replication challenges and solutions are the same for different organisms. As a result, the replication factors that solve these problems are highly conserved in terms of structure, chemistry, functionality, or sequence.