Complex sentence: Phosphorylation of TRPV1 by protein kinase C have been shown to play a role in sensitization of TRPV1, the cleavage of PIP2 by PLC-beta can result in disinhibiton of TRPV1 and consequently contribute to the sensitivity of TRPV1 to noxious stimuli.
Split into simpler sentences: Phosphorylation of TRPV1 by protein kinase C have been shown to play a role in sensitization of TRPV1. The cleavage of PIP2 by PLC-beta can result in disinhibiton of TRPV1 and, as a consequence, contribute to the sensitivity of TRPV1 to noxious stimuli.