Complex sentence: It often requires treatment with intravenous or intrathecal vancomycin yet it is debatable as to whether its use has any impact on outcome: the removal of any neurological devices is a crucial part of the management of these infections.
Split into simpler sentences: It often requires treatment with intravenous vancomycin; intrathecal vancomycin is often used; yet it is debatable as to whether its use has any impact on outcome. The removal of any neurological devices is a crucial part of the management of these infections.