Complex sentence: The tool use in tool-assisted speed running is therefore different from the sort of state manipulation tools like Gameshark allows, since a speed run using the latter would not be possible to express as just a sequence of key presses.
Split into simpler sentences: The tool use in tool-assisted speed running is therefore different from the sort of state manipulation tools that can be used in other products, such as Gameshark. A speedrun using the Gameshark tool would not be possible, as the run could not be expressed as just a sequence of key presses.