Complex sentence: He played Lt. Col. James Doolittle in the film, which, with a worldwide box office of $449,220,945, remains the highest-grossing film Baldwin has appeared in during his acting career.
Split into simpler sentences: He played Lt. Col. James Doolittle in the film. With a worldwide box office of $449,220,945, this film remains the highest-grossing film Baldwin has appeared in during his acting career.