Complex sentence: The activation of c-Src causes the dephosphorylation of the tyrosine 527 which causes the structure to be destabilized and then result in the opening up of the SH3, SH2 and the kinase domains and autophosphorylation of tyrosine 416.
Split into simpler sentences: The activation of c-Src causes the dephosphorylation of the tyrosine 527. This induces long-range allostery via, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and the kinase domains and autophosphorylation of tyrosine 416.