Complex sentence: This aggregated cytosolic calcium binds calmodulin, which can then activate calcineurin, calcineurin, in turn, activates NFAT, which then translocates to the nucleus.
Split into simpler sentences: This aggregated cytosolic calcium binds calmodulin, which can then activate calcineurin. Calcineurin, in turn, activates NFAT, which then translocates to the nucleus.