Complex sentence: Overall, there have been extensive studies on the exact mechanism of this reaction, however some questions that remain include how conformational constraint of the flexible substrate, specific hydrogen bonding to the transition state, and electrostatic interactions actually contribute to catalysis.
Split into simpler sentences: Overall, there have been extensive studies on the exact mechanism of this reaction. However, some questions that remain include how conformational constraint of the flexible substrate, specific hydrogen bonding to the transition state, and electrostatic interactions actually contribute to catalysis.