Complex sentence: TOP1 and TOP2 activity is reduced by approximately 60% in presence of 5mN exogenous SA. This phenolic compound inhibits TOP enzymes by a non-competitive mechanism where SA binds in a site different to the active site.
Split into simpler sentences: TOP1 and TOP2 activity is reduced by approximately 60% in presence of 5mN. SA inhibits TOP enzymes by a non-competitive mechanism where SA bind in a site different to the active site.