Complex sentence: There is a lot of evidence supporting the role of CO in the nociceptive signalling in different types of pain models in mammals, in the past 2 decades research on HO inhibitors has shown reduced pain behaviours in models of inflammatory and neuropathic pain.
Split into simpler sentences: There is a lot of evidence supporting the role of CO in the nociceptive signalling found in different types of pain models in mammals. In the past 2 decades research on HO inhibitors has shown reduced pain behaviours in models of inflammatory and neuropathic pain.