Complex sentence: From there, ced-3 is localized to perinuclear regions of the cells and in order for ced-3 to be functional, it requires auto-catalytic cleavage which is initiated by ced-4, acting as an initiator caspase.
Split into simpler sentences: From there, ced-3 is found to be localized to perinuclear regions of the cells. In order for ced-3 to be functional, it requires auto-catalytic cleavage which is initiated by ced-4, acting as an initiator caspase.