Complex sentence: It is suggested that misfolded proteins bind with pattern-recognition receptors on the astroglia and microglia which triggers an innate immune response in the release of inflammatory mediators that contribute to the severity and progression of the disease.
Split into simpler sentences: It is suggested that misfolded proteins bind with pattern-recognition receptors on the astroglia and microglia. This then triggers an innate immune response in the release of inflammatory mediators which contribute to the severity and progression of the disease.