Complex sentence: He and his band members were formally trained African American musicians, who did not grow up with the blues, yet Handy was able to adapt the blues to a larger band instrument format, and arrange them in a popular music form.
Split into simpler sentences: He and his band members were formally trained African American musicians, who did not grow up with the blues. Yet, Handy was able to adopt the blues to a larger band instrument format, and arrange them in a popular music form.