Complex sentence: His major work was the Dissertation on the Pernicious Effects of Gaming', and it gained a prize of fifty guineas offered through the University of Cambridge; the first edition appeared at Cambridge in 1783, and the third in 1812.
Split into simpler sentences: His major work was the "Dissertation on the Pernicious Effects of Gaming", awarded a prize of fifty guineas from the University of Cambridge. The first edition appeared at Cambridge in 1783, and the third in 1812.