Complex sentence: Chronic renal failure causes excess fluid retention that is often treated with diet adjustments and diuretics Metolazone may be combined with other diuretics (typically loop diuretics) to treat diuretic resistance in CHF, chronic renal failure, and nephrotic syndrome.
Split into simpler sentences: Chronic renal failure causes excess fluid retention that is often treated with diet adjustments and loop diuretics; metolazone is frequently prescribed in addition to the loop diuretic. This combination may be used to treat diuretic resistance in CHF, chronic renal failure, and nephrotic syndrome.