Complex sentence: He became a successful businessman, developing the D.H. Holmes department store business in New Orleans in 1842, and opening his store in 1849; it was the largest in the South, with more than 700 employees.
Split into simpler sentences: He became a successful businessman, developing the D.H. Holmes department store business in New Orleans in 1842 and opening the store in 1849. It was the largest in the South, with more than 700 employees.