Complex sentence: Two known endogenous inverse agonists are the agouti related peptide (AgRP) and its associated peptide Agouti signaling peptide (ASIP) both are expressed in humans and each bind melanocortin receptors 4 and 1 (Mc4R and Mc1R) respectively with nanomolar affinities.
Split into simpler sentences: Two known endogenous inverse agonists are the Agouti-related peptide (AgRP) and its associated peptide Agouti signaling peptide (ASIP). Both are expressed in humans, and each binds melanocortin receptors 4 and 1 (Mc4R and Mc1R), respectively, with nanomolar affinities.