Complex sentence: Gitelman syndrome is an autosomal recessive kidney disorder characterized by hypokalemic metabolic alkalosis with hypocalciuria, and hypomagnesemia and caused by loss of function mutations of the thiazidesensitive sodium-chloride symporter (also known as NCC, NCCT, or TSC) located in the distal convoluted tubule.
Split into simpler sentences: Gitelman syndrome is an autosomal recessive kidney disorder characterized by hypokalemic metabolic alkalosis with hypocalciuria, and hypomagnesemia. It is caused by loss of function mutations of the thiazidesensitive sodium-chloride symporter (also known as NCC, NCCT, or TSC) located in the distal convoluted tubule.