Complex sentence: In biology TFE is used as a co-solvent in protein folding studies with NMR: this solvent can effectively solubilize both peptides and proteins and it is known that, depending upon its concentration, TFE can strongly affect the three-dimensional structure of proteins.
Split into simpler sentences: In biology TFE is used as a co-solvent in protein folding studies with NMR spectroscopy: this solvent can effectively solubilize both peptides and proteins. Depending upon its concentration, TFE can strongly affect the three-dimensional structure of proteins.