Complex sentence: Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, unbound plasma cortisol in term pregnancy is approximately 2.5 times that of nonpregnant women.
Split into simpler sentences: Hepatic synthesis of corticosteroid-binding globulin doubles in pregnancy. So that unbound plasma cortisol in term pregnancy is approximately 2.5 times that of nonpregnant women.