Complex sentence: Despite this, the October 22 1801 the King of Etruria broke with of its own initiative possession of Mascagni appointed professor of anatomy at University of Pisa, forcing also to take twice a week classes in Florence, at Hospital of Santa Maria Nuova.
Split into simpler sentences: Despite this, in October 22 1801 the King of Etruria appointed Mascagni as professor of anatomy at University of Pisa. This forced him to take classes twice a week in Florence, at Hospital of Santa Maria Nuova.