Complex sentence: One of these is predicting the pKa of an ionizable group, which is a linear combination of a few features, including: depth, number of hydrogen bond, electrostatic energy, solvent accessible surface area.
Split into simpler sentences: One of these is predicting the pKa of an ionizable group. The pKa equation is a linear combination of a few features, including: depth, number of hydrogen bond, electrostatic energy, solvent accessible surface area.