Complex sentence: It runs East to West, but is most noted for its strip between 10th and 11th Avenues, known as Club Row because it features some of the world's most exclusive nightclubs and lounges.
Split into simpler sentences: It runs East to West, but is most noted for its strip between 10th and 11th Avenues. The street is nicknamed Club Row because it features some of the world's most exclusive nightclubs and lounges.