Complex sentence: Due to the risk of organ (especially renal) toxicity, methoxyflurane is discouraged from use in patients with pre-existing kidney disease, and is not recommended to be administered in conjunction with other potentially nephrotoxic drugs.
Split into simpler sentences: Due to the risk of organ (especially renal) toxicity, methoxyflurane is discouraged from use in patients with pre-existing kidney disease. It is not recommended to be administered in conjunction with other potentially nephrotoxic drugs.