Complex sentence: The first wife of a Vice President to have an office in the building was Marilyn Quayle, wife of James Danforth Quayle, who served as the Vice President to George H.W. Bush.
Split into simpler sentences: The first wife of a Vice President to have an office in the building was Marilyn Quayle, wife of James Danforth Quayle. He served as the Vice President to George H.W. Bush.