Complex sentence: In common with other orthomyxoviruses, viral transcription and replication occur in the cell nucleus, and replication has in some cases been shown to be sensitive to the Mx1/MxA protein, which is induced in mice and humans in response to interferon.
Split into simpler sentences: In common with other orthomyxoviruses, viral transcription and replication both occur in the cell nucleus. Replication has in some cases been shown to be sensitive to the Mx1/MxA protein, which is induced in mice and humans in response to interferon.