Complex sentence: MUC16 might also play a role in reducing the sensitivity of cancer cells to drug therapy because the hydrophilic extracellular environment created by MUC16 can be difficult for drugs to penetrate.
Split into simpler sentences: MUC16 might also play a role in reducing the sensitivity of cancer cells to drug therapy. This is likely due to the hydrophilic environment created by the presence of MUC16, which can be difficult for drugs to penetrate.