Complex sentence: In simple terms, amphetamine (i.e., Adderall) works mainly by dose-dependently increasing the activity of the neurotransmitters dopamine and norepinephrine in the central nervous system (CNS), specifically, in the nucleus accumbens, prefrontal cortex, and locus coeruleus.
Split into simpler sentences: In simple terms, Adderall (i.e., amphetamine) works mainly by dose-dependently increasing the activity of the neurotransmitters dopamine and norepinephrine in the central nervous system (CNS). The therapeutic benefits of Adderall arise from its effect on these neurotransmitters in the nucleus accumbens, prefrontal cortex, and locus coeruleus.