Complex sentence: Neither the Sapirs nor the Delsons were in favor of the match: the Delsons who hailed from the prestigeous Jewish center of Vilna considered the Sapirs to be rural upstarts and were less than impressed with Sapir's career in an unpronounceable academic field.
Split into simpler sentences: Neither the Sapirs nor the Delsons were in favor of the match. The Delsons, who hailed from the prestigeous Jewish center of Vilna, considered the Sapirs to be rural upstarts and were less than impressed with Sapir's career in an unpronounceable academic field.