Complex sentence: Most of the distance that U.S. Highway 411 travels is rural countryside, with no major metropolitan areas along its route, although it passes near the cities of Birmingham, Alabama, Atlanta, Georgia and Knoxville, Tennessee.
Split into simpler sentences: Most of the distance through which U.S. Highway 411 passes is rural countryside, with no major metropolitan areas along its route. However, it does pass relatively near the cities of Birmingham, Alabama, Atlanta, Georgia and Knoxville, Tennessee.