Complex sentence: In another study, bicalutamide treatment of LNCaP cells resulted in two LBD mutations, W741L and W741C, causing bicalutamide to acquire agonist activity to both mutant ARs.
Split into simpler sentences: In another study bicalutamide treatment of LNCaP cells resulted in two LBD mutations, W741L and W741C. Bicalutamide is then able to acquire agonist activity to both mutant ARs.