Complex sentence: Two domains of TRIM25 (RING and SPRY) mediate its interaction with RIG-I. This interaction allows TRIM25 to ubiquitinate RIG-I. It follows IFN production by an intracellular signaling pathway involving IRF3.
Split into simpler sentences: Two domains of TRIM25 (RING and SPRY) allow an interaction with RIG-I. Thanks to this interaction an ubiquitination of RIG-I by TRIM25 is possible. Its follows an IFN production by an intracellular signaling pathway involving IRF3.