Complex sentence: The melting and gelling temperature of agarose can be modified by chemical modifications, most commonly by hydroxyethylation, which reduces the number of intrastrand hydrogen bonds, resulting in lower melting and setting temperature than standard agaroses.
Split into simpler sentences: The melting and gelling temperature of agarose can be modified by chemical modifications, most commonly by hydroxyethylation. Hydroxyethylation of agarose reduces the number of intrastrand hydrogen bonds, resulting in lower melting and setting temperature than standard agaroses.