Complex sentence: The role of hTIM in the intra-S checkpoint is less clear at the molecular level; however, down-regulation of hTIM leads to an increase in the rate of generation of replication forks--even in the presence of DNA damage and other regulatory responses.
Split into simpler sentences: The role of hTIM in the intra-S checkpoint is less clear at the molecular level. However, down-regulation of hTIM leads to an increase in the rate of generation of replication forks--even in the presence of DNA damage and other regulatory responses.