Complex sentence: Some actors might struggle with, and be made uncomfortable by the rolls they have to play, for instance if they have to kiss another male, if they're heterosexual, which would be a challenge for most people.
Split into simpler sentences: Some actors might struggle with, and be made uncomfortable by the rolls they have to play, for instance if they have to kiss another male, if they're heterosexual. Were heterosexual and they had to kiss another male, which would be a challenge for most people.