Complex sentence: Following interaction with their specific ligands, chemokine receptors trigger a flux in intracellular calcium (Ca 2 +) ions (calcium signaling), which generates a chemotactic response of that cell, thus trafficking the cell to a desired location within the organism.
Split into simpler sentences: Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca 2 +) ions (calcium signaling) within the cell. This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism.