Complex sentence: The first area known as Uptown was centred on Bloor Street around the University of Toronto in the nineteenth century this was the northern fringe of the city, and when the university was established it was still largely rural.
Split into simpler sentences: The first area known as Uptown was centred on Bloor Street around the University of Toronto. In the nineteenth century, this was the northern fringe of the city; when the university was established it was still largely rural.