Complex sentence: Amyotrophic lateral sclerosis (ALS) affects upper and lower motor systems, with symptoms ranging from muscle atrophy, to hyperreflexia, or fasciculations, all of which suggest increased axonal excitability.
Split into simpler sentences: Amyotrophic lateral sclerosis (ALS) affects upper and lower motor systems. Symptoms include muscle atrophy, hyperreflexia, and fasciculations, all of which suggest increased axonal excitability.