Complex sentence: Frederik L. Schodt observed that Nausicaä is different from other Japanese manga, largely due to the fact that it was serialized in the large A4 size of "Animage", much larger than the normal size for manga.
Split into simpler sentences: Frederik L. Schodt observed that Nausicaä is different from other Japanese manga. Noting that it was serialized in the large A4 size of "Animage", much larger than the normal size for manga.