Complex sentence: It runs from the I-10/SR 51 Mini Stack interchange to US Route 60 (US 60), and passes over the Salt River and through Tempe and Mesa en route, with an interchange with Loop 101 in Tempe.
Split into simpler sentences: It runs from the I-10/SR 51 Mini Stack interchange to US Route 60 (US 60). It passes over the Salt River and through Tempe and Mesa en route, with an interchange with Loop 101 in Tempe.