Complex sentence: Screening at an age lower than 16 would lead to an unacceptably high rate of false positives; however screening of toddlers has been suggested, and results of a trial on 10,000 one-year-olds were published in 2016.
Split into simpler sentences: Screening at an age lower than 16 was thought likely to lead to an unacceptably high rate of false positives. Screening of toddlers has been suggested, and results of a trial on 10,000 one-year-olds were published in 2016.