Complex sentence: Oral opioids, including both weak opioids such as tramadol and more potent opioids, are also often prescribed; their appropriateness is uncertain and often recommended only when first line therapies have failed or are contraindicated.
Split into simpler sentences: Oral opioids, including both weak opioids such as tramadol and stronger opioids, are also often prescribed. Their appropriateness; however, is uncertain and often recommended only when first line therapies have failed or are contraindicated.