Complex sentence: He was the second son of Francis of Lorraine, Duke of Guise and Anna d'Este, the daughter of Ercole d'Este II, Duke of Ferrara and Renée of France.
Split into simpler sentences: He was the second son of Francis of Lorraine, Duke of Guise and Anna d'Este. His maternal grandparents were Ercole d'Este II, Duke of Ferrara and Renée of France.