Complex sentence: I-440 and I-540, and seven U.S. Routes: 1,64,70,264,401,15 and 501 which are multiplexed through much of the region as US 15-501.
Split into simpler sentences: I-440 and I-540, and seven U.S. Routes: 1,15,64,70,264, and 501. US Highways 15 and 501 are multiplexed through much of the region as US 15-501.