Complex sentence: A barium enema has proven to be a poor diagnostic tool because, while failure of the appendix to fill during a barium enema has been associated with appendicitis, this finding lacks both sensitivity and specificity because up to 20% of normal appendices also do not fill.
Split into simpler sentences: A barium enema has proven to be a poor diagnostic tool for appendicitis. While failure of the appendix to fill during a barium enema has been associated with appendicitis, this finding lacks both sensitivity and specificity because up to 20% of normal appendices also do not fill.