Complex sentence: The first story arc, set in 1792, was western-inspired, with much horseback riding, gunfights and the sympathically-portrayed native Ainu people "replacing" the Indians on the Frontier-like Ezo (modern Hokkaidō).
Split into simpler sentences: The first story arc, set in 1792, was western-inspired, with much horseback riding, gun fighting. It portrays the native Ainu people sympathetically as they replace the Indians in the frontier-like Ezo (modern Hokkaidō).