Complex sentence: It is set in the Marvel Cinematic Universe (MCU), sharing continuity with the films of the franchise, and is scheduled to air for 22 episodes on ABC beginning on September 20,2016.
Split into simpler sentences: It is set in the Marvel Cinematic Universe (MCU), sharing continuity with the films of the franchise. The season, consisting of 22 episodes, is scheduled to air on ABC beginning on September 20,2016.