Complex sentence: Machala has a population of 241,606 (2010 census), it is also the fourth biggest city of the country; and the second most important port, it has been referred to as the "Banana Capital of the World".
Split into simpler sentences: Machala has a population of 241,606 (2010 census); it is the fourth biggest city of the country, and the second most important port. It has been referred to as the "Banana Capital of the World".