Complex sentence: Hispanic or Latino Americans (of any race) make up the largest ethnic minority in the United States and form the second largest group after non-Hispanic Whites in the United States, making up 16.3% of the population, according to the 2010 United States Census.
Split into simpler sentences: Hispanic or Latino Americans (of any race) constitute the largest ethnic minority in the United States. They form the second largest group after non-Hispanic Whites in the United States, comprising 16.3% of the population according to the 2010 United States Census.