Complex sentence: By the late 1700s a number of crude ginning machines had been developed, however, to produce a bale of cotton required over 600 hours of human labor, making large scale production uneconomical in the United States, even with the use of humans as slave labor.
Split into simpler sentences: By the late 1700s a number of crude ginning machines had been developed. However, to produce a bale of cotton required over 600 hours of human labor, making large scale production uneconomical in the United States, even with the use of humans as slave labor.