Complex sentence: Born in England, he served as his family's business agent in Spain and the Canary Islands in his early twenties, then moved to Virginia in 1653, replacing his brother Edward, who had died.
Split into simpler sentences: Born in England, he served as his family's business agent in Spain and the Canary Islands in his early twenties. He moved to the colony of Virginia in 1653, to replace his brother Edward, who had died.