Complex sentence: Güshi was known for his devotion to the Gelugpa and responded positively; however, as it turned out, it would take several years to install Lozang Gyatso as the head of a unified Tibetan state.
Split into simpler sentences: Güshi was known for his devotion to the Gelugpa and responded positively. As it turned out, it would nevertheless take several years to install Lozang Gyatso as the head of a unified Tibetan state.