Complex sentence: Hydrophobic drugs with high octanol/water partition coefficients are preferentially distributed to hydrophobic compartments such as the lipid bilayers of cells while hydrophilic drugs (low octanol/water partition coefficients) preferentially are found in aqueous compartments such as blood serum.
Split into simpler sentences: Hydrophobic drugs with high octanol/water partition coefficients are mainly distributed to hydrophobic areas such as lipid bilayers of cells. Conversely hydrophilic drugs (low octanol/water partition coefficients) are found in mainly in aqueous regions such as blood serum.