Complex sentence: The village lies 20 km north-west of Bordeaux and is best known as the northernmost, and one of the four major wine growing appellations of the Médoc, home to many of the world's most-prized red wines.
Split into simpler sentences: The village lies 20 km north-west of Bordeaux. Saint-Estèphe is best known as the northernmost, and one of the four major wine growing appellations of the Médoc, home to many of the world's most-prized red wines.