Complex sentence: The Appomattoc (also spelled Appamatuck, Apamatic, and numerous other variants) were an Algonquian tribe of the Powhatan Confederacy, and the native inhabitants of the lower Appomattox River in what is now Virginia.
Split into simpler sentences: The Appomattoc (also spelled Appamatuck, Apamatic, and numerous other variants) were a historic Algonquian-speaking tribe affiliated with the Powhatan Confederacy. They were the native inhabitants of the lower Appomattox River in what is now Virginia.