Complex sentence: Some early settlers of Wilmington came from the Albemarle and Pamlico regions of the state, as well as from Virginia and South Carolina, but most new settlers arrived from the northern colonies, the West Indies, and the British Isles.
Split into simpler sentences: Some early settlers of Wilmington came from the Albemarle and Pamlico regions of the state, as well as Virginia and South Carolina. Most new settlers arrived from the northern colonies, the West Indies, and the British Isles.