Complex sentence: Usually seen in defective globin chain synthesis, for example hemoglobinopathies, sickle cell disease and thalassemia; this causes the two sides of RBCs which are usually separated by an area of central pallor to be apposed given the Bull's eye/target appearance.
Split into simpler sentences: Usually seen in defective globin chain synthesis, for example hemoglobinopathies, sickle cell disease and thalassemia. This causes the two sides of RBCs which are usually separated by an area of central pallor to be apposed given the Bull's eye/target appearance.