Complex sentence: As the head of an ecclesiastical province, Loayza was vigorous in his efforts at establishing the mission of the Catholic Church in the New World, continuing to show the spirit of concern for the welfare of the indigenous population he had demonstrated in Cartagena.
Split into simpler sentences: As the head of an ecclesiastical province, Loayza was vigorous in his efforts to establish the mission of the Catholic Church in the New World. He continued to show his concern for the welfare of the indigenous population which he had demonstrated in Cartagena.