Complex sentence: The neuronal axons of the mesolimbic dopamine system, a key component of the reward circuitry, generally have high thresholds for stimulation, however these thresholds can be increased or decreased by drug administration, influencing sensitivity to intracranial stimulation and ICSS behavior.
Split into simpler sentences: The neuronal axons of the mesolimbic dopamine system, a key component of the reward circuitry, generally have high thresholds for stimulation. However, these thresholds can be increased or decreased by drug administration, influencing sensitivity to intracranial stimulation and ICSS behavior.