Complex sentence: The personalities of Ed, Edd, and Eddy are based on his own traits, and the activities of his two sons while the cul-de-sac children and the Kanker sisters were all based on children he grew up with.
Split into simpler sentences: The personalities of Ed, Edd, and Eddy are based on personal traits of himself, and the activities of his two sons. The cul-de-sac children and the Kanker Sisters were all based on children he grew up with.