Complex sentence: Witherspoon's first post-Oscar role came in the modern-day fairy tale "Penelope", as Annie, the best friend of Penelope (Christina Ricci), a girl who has a curse in her family.
Split into simpler sentences: Witherspoon's first post-Oscar role came in the modern-day fairy tale "Penelope", co-starring Christina Ricci. Witherspoon played Annie, the best friend of Penelope, a girl who has a curse in her family.