Complex sentence: Both in Spain and in the New World aggressively prosecuted crypto-Jews (Converts who continued to practice Judaism), many of whom were Portuguese merchants in Mexico City and Lima, following the successful revolt of Portugal in 1640 against the Castillian Crown.
Split into simpler sentences: Both in Spain and in the New World crypto-Jews (Converts who continued to practice Judaism) were aggressively prosecuted. Some emigrated as Portuguese merchants to Mexico City and Lima, following the successful revolt of Portugal in 1640 against the Castillian Crown.