Complex sentence: Beatriz de la Cueva was buried in the cathedral of the rebuilt Santiago de los Caballeros de Guatemala at the insistence of the bishop in spite of local opposition, and Leonor had Pedro de Alvarado reburied at her side in 1580.
Split into simpler sentences: Beatriz de la Cueva was buried in the cathedral of the rebuilt Santiago de los Caballeros de Guatemala despite local opposition. At the insistence of the bishop and Leonor, Pedro de Alvarado was reburied at her side in 1580.