Complex sentence: She is best known for anchoring prime time newscasts on CNN Headline News from 1983 to 2001, which made her the first woman to anchor a nationally-televised prime time news program.
Split into simpler sentences: She is best known for anchoring prime time newscasts on CNN Headline News from 1983 to 2001. This stint made her the first woman to anchor a nationally-televised prime time news program.