Complex sentence: The University's newest academic building Wabash, is located in the area of Downtown Chicago called The Loop and is the tallest educational building in Chicago, the second tallest educational building in the United States and the sixth largest academic complex in the world.
Split into simpler sentences: The University's newest academic building, Wabash, is located in The Loop of Downtown Chicago. It is the tallest educational building in Chicago, the second tallest educational building in the United States, and the sixth-largest academic complex in the world.