Complex sentence: They are primarily activated by membrane receptor associated Janus kinase (JAK) and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression.
Split into simpler sentences: They are primarily activated by membrane receptor associated Janus kinase (JAK). Dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression.