Complex sentence: The first DTI was actually hirudin, which became more easily available with genetic engineering, it is now available in a recombinant form as lepirudin (Refludan) and desirudin (Revasc, Iprivask).
Split into simpler sentences: The first DTI was actually hirudin, which became more easily available with genetic engineering. It is now available in a recombinant form as lepirudin (Refludan) and desirudin (Revasc, Iprivask).