Complex sentence: The basal ganglia balances excitation and inhibition of the thalamo-cortical circuit involved in motor execution; this balance is thought to be altered in task-specific dystonias due to reduced GABAergic metabolism and dopaminergic receptor binding--this leads to excessive motor cortical excitation.
Split into simpler sentences: The basal ganglia balances excitation and inhibition of the thalamo-cortical circuit involved in motor execution. This balance is thought to be altered in task-specific dystonias due to reduced GABAergic metabolism and dopaminergic receptor binding--this leads to excessive motor cortical excitation.