Complex sentence: It has also been shown that imbalances between angiopoietin-1 and angiopoietin-2 can act independently such that one might signal at high levels while the other remains at normal level signaling.
Split into simpler sentences: It has also been shown that imbalances between angiopoietin-1 and angiopoietin-2 signaling can act independently of each other. One angiopoietin factor can signal at high levels while the other angiopoieting factor remains at baseline level signaling.