Complex sentence: Eight mutations have been identified-four are nonsense mutations, one is a deletion that includes most of the transcriptional unit, and the other three are missense mutations and frameshift mutations, which lead to a shortening of amino acid sequence in the C terminus.
Split into simpler sentences: Eight mutations have been identified-four are nonsense mutations, one is a deletion that includes most of the transcriptional unit. The other three are missense mutations and frameshift mutations, which lead to a shortening of amino acid sequence in the C terminus.