Complex sentence: It used to be that the 3D structure of proteins could only be determined using X-ray crystallography and NMR spectroscopy but now, through bioinformatics, there are computer programs that can predict and model the structure of proteins.
Split into simpler sentences: It used to be that the 3D structure of proteins could only be determined using X-ray crystallography and NMR spectroscopy. Now, through bioinformatics, there are computer programs that can predict and model the structure of proteins.