Complex sentence: Most of the town's residents live in and around the downtown area; however, a large portion of the town's residents live on the east side of town along Tennessee State Route 57, between Grand Junction and Saulsbury.
Split into simpler sentences: Most of the town's residents live in and around the downtown area. However, a large portion of the town's residents live on the east side of town along Tennessee State Route 57, between Grand Junction and Saulsbury.