Complex sentence: Looms were active in all the Flemish cities, and in most of the towns and many of the villages, a fact that allowed the region to sub-contract and produce such a high output; commissions could be farmed out and distributed across a large number of weavers.
Split into simpler sentences: Looms were active in all the major Flemish cities, in most of the towns and in many of the villages, a fact that allowed the region to sub-contract and thus produce such a high output. Commissions could be farmed out and distributed across a large number of weavers.