Complex sentence: Irrefutable proof of ceRNA-mediated gene regulation however still remains to be shown, since most studies either overexpress RNA transcripts at unphysiological levels or lack seed mutation controls when up-or downregulating potential ceRNA transcripts.
Split into simpler sentences: Irrefutable proof of ceRNA-mediated gene regulation still remains to be shown. Most studies either overexpress RNA transcripts at unphysiological levels or lack seed mutation controls when up-or downregulating potential ceRNA transcripts.