Complex sentence: The best known outside of the region is the Northwestern University Bienen School of Music, however the Chicago College of Performing Arts at Roosevelt University and the School of Music at Depaul University are both working to expand their reputations.
Split into simpler sentences: The best known outside of the region is the Northwestern University Bienen School of Music. The Chicago College of Performing Arts at Roosevelt University and the School of Music at Depaul University are both working to expand their reputations.