Complex sentence: It flows through and past a number of cities, including Vicenza and Padua, and acted for many centuries as a significant waterway up to Vicenza, above which it ceases to be navigable.
Split into simpler sentences: It flows through and past a number of cities, including Vicenza and Padua. It acted for many centuries as a significant waterway up to Vicenza, above which it ceases to be navigable.