Complex sentence: Going to Italy, he was opposed by prominent Jews including Jacob Mantino ben Samuel, who feared that he might mislead their co-religionists, but he succeeded in gaining the favor of Pope Clement VII and of some Judeophile cardinals at Rome.
Split into simpler sentences: Going to Italy, he was opposed by prominent Jews including Jacob Mantino ben Samuel, who feared that he might mislead their co-religionists. He succeeded in gaining the favor of Pope Clement VII and of some Judeophile cardinals at Rome.