Complex sentence: The greater Tarbes area is the economic and administrative focus of the "département", while Lourdes, the second-biggest city in Hautes-Pyrénées, is dedicated almost exclusively to the religious pilgrimage industry.
Split into simpler sentences: The greater Tarbes area is the economic and administrative focus of the département. Lourdes is the second-biggest city in Hautes-Pyrénées, dedicated almost exclusively to the pilgrimage industry.