Complex sentence: In 2005, brewing was moved out of Newcastle upon Tyne for the first time, to Dunston in Gateshead on the other side of the River Tyne, and in 2010 production moved entirely to Tadcaster, North Yorkshire.
Split into simpler sentences: In 2005, brewing was moved out of Newcastle for the first time to the other side of the River Tyne, to Dunston in Gateshead. In 2010, production moved entirely to Tadcaster, North Yorkshire.