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Which of the following clinical laboratory observations is suggestive of Hanup disease?: (A) Burnt sugar smell in urine, (B) High plasma phenylalanine levels, (C) Extremely high levels of citrulline in urine, (D) High fecal levels of tryptophan and indole derivatives | Answer is D. High fecal levels of tryptophan and indole derivatives Hanup disease is autosomal recessive metabolic disorder also known as pellagra like dermatosis. This affect the absorption of nonpolar( neutral ) amino acids specially tryptophan. So there is no absorption of tryptophan. | |
All are true about pathogenesis of Ovarian Hyperstimulation Syndrome, EXCEPT?: (A) Due to ovarian enlargement and fragility, (B) Increase in intravascular volume, (C) Role of VEGF and inflammatory cytokines, (D) Secondary to infeility treatment | Answer is B. Symptoms of OHSS are the result of ovarian enlargement and fragility, extravascular fluid accumulation, and intravascular volume depletion (and not increase as stated in option b). Fluid shifts that accompany OHSS are due to increased protein-rich fluid secretion from the stimulated ovaries, increased reni... | |
Biological value of a protein is related to: (A) Nitrogen content, (B) amino acid content, (C) Sulphur content, (D) Energy content | Answer is A. Ans) a (Nitrogen content) Ref paik 20th ed p 549Biological value of a protein is Retained N2 / Absorbed N2 x 100Protein efficiency ratio = Wt gain in gms / Gram of protein consumedNet protein utilization =Digestibility Coefficent x Biological value100 Aminoacid score =No of mg of one AA/gm of proteinNo of ... | |
The study for correlation of genetic disease to consanguinity -: (A) Case Contral Study, (B) Cohort study, (C) Cross-sectional study, (D) Case report | Answer is A. Ans. is 'a' i.e., Case Control Study " The association of consanguinity with complex disorders can be studied using different approaches. For example, epidemialogial surveys could compare the frequency of a disorder in the progeny offirst cousin parents with that of unrelated parents, whereas case-control ... | |
Von Gierke&;s occurs due to deficiency of: (A) Glucose-6-phosphatase, (B) Liver Phosphorylase, (C) Muscle phosphorylase, (D) Debranching enzyme | Answer is A. Glycogen storage disease type I (GSD I) or von Gierke&;s disease, is the most common of the glycogen storage disease. This genetic disease results from deficiency of the enzyme glucose-6-phosphatase and has an incidence in the American population of approximately 1 in 100,000 bihs.Ref: DM Vasudevan, 7th ed... | |
A 38 year old male has paroxysmal hypeension. He is subsequently found to have medullary carcinoma of the thyroid, pheochromocytoma, and mucosal neuromas. Parathyroid involvement is not noted. What is the most likely diagnosis?: (A) MEN type I, (B) MEN type II, (C) MEN type III, (D) Sipple's syndrome | Answer is C. MEN III, also known as MEN IIb, is characterized by medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas.Wermer's syndrome is also called MEN type I . It is characterized by pancreatic (insulinoma), pituitary, and parathyroid involvement.Sipple's syndrome, or MEN type II , is similar to MEN ... | |
Mrs Shikha, 50-years-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus? NOT RELATED -anatomy: (A) Common iliac nodes, (B) Parametrial nodes, (C) External iliac node, (D) Paracervical or ureteral nodes | Answer is D. . | |
A viral infection causes damage to both hippocampi in a patient. This damage would cause the patient to exhibit functional deficits in: (A) Recalling an old declarative memory, (B) Recalling an old procedural memory, (C) Forming a new sho-term memory, (D) Forming a new long-term memory | Answer is D. The hippocampus is crucial for the formation of long-term (declarative) memory. Without the hippocampus, sho-term memory is intact but the conversion to long-term does not take place.The retrieval of stored declarative memory does not require the hippocampus. The hippocampus is not needed for the retrieval... | |
Type of collagen maximum in skin:-: (A) Type I, (B) Type II, (C) Type III, (D) Type IV | Answer is A. Collagen - the most abundant protein in mammals contains 4-hydroxyproline and 5-hydroxylysine. Vitamin C plays the role of a coenzyme in hydroxylation of proline and lysine while protocollagen is conveed to collagen The hydroxylation reaction is catalysed by lysyl hydroxylase (for lysine) and prolyl hydrox... | |
Rotameters: (A) Depend on laminar low for their accuracy, (B) Will only function when upright, (C) Are constant pressure drop-constant orifice devices, (D) Are not accurate below 1L/min | Answer is B. Rotameters are constant pressure drop-variable orifice devices. They are accurate at values as low as 200mL/min both laminar and turbulent flow determine their accuracy . | |
Which of the following is true of Wilson's disease all except -: (A) Autosomal recessive, (B) Serum ceruloplasmin level < 20 mg/d1, (C) Urinary coppor excretion < 100 microgram/c11, (D) Zinc acetate is used as maintence therapy | Answer is C. Urinary copper excretion <100 microgram/di Symptomatic pts. of Wilson disease invariably have urine copper levels > 100 pg per day. Wilson disease is an autosomal recessive disorder caused by mutation in the ATP 7B gene (a copper transpoing ATPase) Diagnosis - The gold standard for diagnosis is Liver biops... | |
A 25 year male presented with high grade fever, headache, neck stiffness, on examination found to have neck rigidity, kernig's sign positive, csf analysis showed neutrophilic predominance, low glucose and limulus amebocyte lysate assay was positive. Which of the following is the likely pathogen?: (A) Staphylococcus aur... | Answer is C. The Limulus amebocyte lysate assay is a rapid diagnostic test for the detection of gram-negative endotoxin in CSF and thus for making a diagnosis of gram-negative bacterial meningitis. The test has a specificity of 85-100% and a sensitivity approaching 100%. Thus, a positive Limulus amebocyte lysate assay ... | |
Tuberculin test denotes:: (A) Previous or present sensitivity to tubercle proteins, (B) Patient is resistant to TB, (C) Person is susceptible to TB, (D) Protective immune status of individual against TB | Answer is A. Ans. is 'a' i.e., Previous or present sensitivity to tubercle proteins(a) Tuberculin test denotes Type IV (delayed) hypersensitivity to tuberculoprotein 0.1 ml (Purified protein derivative) and used in diagnosis of latent tuberculosis.(b) Positive tuberculin test indicates exposure to Mycobacterium tubercu... | |
Tumor suppressor gene p53 prevents carcinoma by?: (A) DNA repair, (B) Cell cycle arrest, (C) Apoptosis induction, (D) All of the above | Answer is D. Ans. is 'd' i.e., All of the above * p53 gene is located on chromosome 17 & acts as molecular policeman that prevents the propagation of genetically damage cell. p53 gene product, i.e. p53 protein is a DNA binding protein in the nucleus, when called into action, it controls the transcription of several oth... | |
Most specific enzyme for mi is:: (A) Cpk-MM, (B) Cpk-MB, (C) Cpk-BB, (D) LDH | Answer is B. Ans: bRef: Harrison, 16thed, p. 1450 | |
Which of the following is not a part of fatty acid synthase Complex?: (A) Ketoacyl reductase, (B) Enoyl reductase, (C) Acetyl-CoA carboxylase, (D) Ketoacyl synthase | Answer is C. Ans. C. Acetyl-CoA carboxylase(Ref: Harper 31/e page 217)Fatty Acid Synthase (FAS) Multienzyme ComplexThe complex is a homodimer of two identical polypeptide monomers in which six enzyme activities and the acyl carrier protein (ACP)ACP contains the vitamin pantothenic acid in the form of 4'-phosphopantethe... | |
All of the followings are responsible for Right shifting of O2 saturation curve; except:: (A) Hypoxia, (B) Hypocapnia, (C) Increase temp, (D) Increased 2,3 DPG | Answer is B. Ans. b. HypocapniaThe factors shift the curve to the right:Increased CO2 (Bohr effect)Increased hydrogen ion (decrease pH)Increased temperatureIncreased 2,3-bisphosphoglycerate (2,3-BPG)Shifts in Hb-O2 dissociation curveStored blood loses 2, 3-bisphosphoglycerate, causing a left shift in the curve, while h... | |
A nineteen year old female with short stature, wide spread nipples and primary amenorrhoea most likely has karyotype of –: (A) 47, XX + 18, (B) 46XXXY, (C) 47, XXY, (D) 45 XO | Answer is D. None | |
True about rash of chickenpox: (A) Centripetal, (B) Deep Seated, (C) Affectspalm, (D) Slow to evolute | Answer is A. Rash of chicken pox : Superficial, unilocular, centripetal, pleomorphic, symmetrical, affects flexor surfaces and axilla, spares palms and sales, has inflammation around, rapid evolution and dew-drop on rose petal appeamace. | |
All are true about Klumpke's paralysis except: (A) Claw hand is never seen, (B) Intrincsic muscles of hand are paralysed, (C) Horner's syndrome can be associated, (D) Involves lower trunk of brachial plexus | Answer is A. Klumpke's paralysis
C8 and T1 roots involved.
Intrinsic muscles of hand paralysed.
Wrist and finger flexous are weak.
Unilateral Horner's syndrome.
Claw hand is seen. | |
Hyperglycemia is seen in all except?: (A) Cirrhosis, (B) Myotonic dystrophy, (C) Lipodystrophy, (D) Sarcoma | Answer is D. In cirrhosis, blood sugar is elevated, due to reduced uptake of sugar by liver. In myotonic dystrophy and lipodystrophy, there is tissue insensitivity to insulin leading to hyperglycemia. Sarcoma especially large retroperitoneal sarcomas secrete IGF-2 and lead to hypoglycaemia. | |
LSD was introducd by: (A) albe hoffman, (B) delay and deniker, (C) John F Cade, (D) Egaz Moniz | Answer is A. Hallucinogens * ALSO CALLED AS Psychotomimetic/ Psychedelic * FIRST Man made HALLICINOGEN ==================== Albe Hoffman * MECHANISM OF ACTION Lysergic acid diethylamide=======serotonin * Introduced by Albe Hoffmann and he himself experienced its effects * Phencyclidine =======NMDA antagonist * Also kno... | |
Decreased basal metabolic rate is seen in: (A) Obesity, (B) Hypehyroidism, (C) Feeding, (D) Exercise | Answer is A. The remaining options utilise energy. Basal metabolic rate and obesity The basal metabolic rate accounts for about 60 to 75% of the daily calorie expenditure by individuals. It is influenced by several factors. BMR typically declines by 1-2% per decade after age 20, mostly due to loss of fat-free mass, alt... | |
A 70 kg athlete is taken for surgery, due to unavailability of vecuronium, succinylcholine is given repeatedly (>640mg). He now is unable to take breath and his lower limbs are paralyzed. What will be cause?: (A) Phase II block, (B) Succinylcholine causes muscle paralysis due to fasciculation, (C) Hidden muscle dystrop... | Answer is A. Prolonged apnea due to repeated dosing with succinylcholine is due to it entering phase 2 block. Phase I depolarizing block is preceded by muscle fasciculation. During paial neuromuscular block, phase I depolarizing block is characterised by: No fade during repetitive stimulation (tetanic or TOF) No post t... | |
Inheritance of ABO blood group is:: (A) X-linked inheritance, (B) Recessive inheritance, (C) Mitochondria] inheritance, (D) Codominance | Answer is D. Ans. d. Codominance (Ref Robbins 9/e p140; Ganong 23/e p527)Inheritance of ABO blood group is Codominance."Although Mendelian traits are usually described as dominant or recessive, in some cases both of the alleles of a gene pair contribute to the phenotype--a condition called codominance. Histocompatibili... | |
Which is not ketogenic: (A) Leucine, (B) Lysine, (C) Methionine, (D) Tryptophan | Answer is C. Ans. is 'c >d' i.e., Methionine > TryptophanLeucine and lysine are purely ketogenic.Trypotophan is not purely ketogenic, but it is ketogenic along with glucogenic. Methionine is purely glucogenic. | |
Glossodynia is: (A) Pain in the tongue, (B) Burning of the tongue, (C) Swelling of the tongue, (D) White patch on tongue | Answer is A. None | |
All are the branches of internal iliac artery except:: (A) Obturator artery, (B) Middle rectal artery, (C) Femoral artery, (D) Internal pudendal artery | Answer is C. Ans. C. Femoral arteryThe internal iliac artery supplies the walls and viscera of the pelvis, the buttock, the reproductive organs, and the medial compartment of the thigh.It arises at the bifurcation of the common iliac artery, opposite the lumbosacral articulation, and, passing downward to the upper marg... | |
SACD (Subacute combined degeneration of cord) is feature of which vitamin deficiency?: (A) Vitamin A, (B) Vitamin B6, (C) Vitamin B9, (D) Vitamin B12 | Answer is D. Ans. d (Vitamin B12) (Ref. H - 17th/pg. Table 71-1).Vitamins: Major FunctionsVITAMINFUNCTIONVitamin AA component of visual pigment; Maintenance of specialized epithelia; Maintenance of resistance to infectionVitamin DFacilitates intestinal absorption of calcium and phosphorus and mineralization of boneVita... | |
Main aim for treatment of TB ?: (A) Prevention of complication, (B) Prevention of disease transmission, (C) Complete clinical cure, (D) Complete bacteriological cure | Answer is D. Ans. is 'd' i.e., Complete bacteriological cure Chemotherapy is indicated in every case of active tuberculosis. The objective of treatment is cure-that is, the elimination of both the fast and slowly multiplying bacilli from the patient's body. The effects of chemotherapy are judged not by the anatomic hea... | |
All of the following are functions of CD 4 helper cells, except-: (A) Immunogenic memory, (B) Produce immnoglobulins, (C) Activate macrophages, (D) Activate cytotoxic cells | Answer is B. CD4 T cells are helper T cells. They stimulate B cells to produce antibodies, release of cytokines and are responsible for memory. They do not directly produce any antibody by their own. Basic Pathology, Robbins. Page no.:101 | |
A 35-year-old man with duodenal stump leak after partial gastrectomy is receiving central parenteral nutrition containing the standard D25W, 4.25% amino acid solution. Which is TRUE of essential fatty acid deficiency seen after hyperalimentation?: (A) It occurs if soybean oil is given only once weekly., (B) It is usual... | Answer is C. Essential fatty acid deficiency usually occurs if hyperalimentation is extended for more than 1 month and when soybean oil is not administered at least twice a week. There is a decrease in linolenic, linoleic, and arachidonic acids and an increase in oleic and palmitoleic acid. In addition to the skin chan... | |
Sacrum becomes a single bone at ___ years of age.:-: (A) 15, (B) 25, (C) 30, (D) 40 | Answer is B. Sacrum The five sacral veebrae are separated by cailage until pubey. Later, fusion of epiphyses takes place and ossification of interveebral discs extend from below upwards. Sacrum becomes single bone at 21-25 years of age. Sometimes, it leaves a gap between S1 and S2, until 32 years called as 'lapsed unio... | |
Which is True about dobutamine?: (A) Dobutamine decreases peripheral resistance, (B) Acts on D1 and D2 receptors, (C) Decrease kidney circulation, (D) Has no effect on coronary circulation | Answer is A. Ref: HL Sharma 3rd ed pg no: 177 Dobutamine is a derivative of dopamine and is a selective beta1 agonist. It causes an increase in the force of contraction without a significant increase in hea rate. It also produces some vasodilatation by stimulating the beta 2 receptors. It doesn't decrease kidney circul... | |
Which of the following statements about cutaneous shunt~vessels is true?: (A) Perform nutritive function, (B) Have role in thermoregulation, (C) Not under the control of autonomic nervous system, (D) These vessels are evenly distributed throughout the skin | Answer is B. These are low resistance connection between the aerioles and veins bypassing the capillariesAbundantly innervated by sympathetic nerve fibresEspecially found in skin of fingers, toes and earlobes where they are involved in the thermoregulationRef: Medical Physiology Indu Khurana 2015 edition page No: 237 | |
Volume of infarcted area in acute myocardial infarction (AMI) can be detected by -a) ECHOb) ECGc) Levels of CPKMBd) Thallium scan: (A) b, (B) c, (C) ac, (D) ad | Answer is D. None | |
Blow out fracture of orbit commonly produces: (A) Deviation of septum, (B) Retinal haemorrhage, (C) Fracture of nasal bones, (D) Fracture of floor of orbit | Answer is D. (D) Fracture of floor of orbit # Blow out fracture of orbit; Intraorbital haemorrhages, proptosis, paralysis of extrinsic muscles and fracture of the floor of the orbit are not infrequent following a blunt injury to the orbital region> Proptosis develops due to reactive oedema and intra-orbital haemorrhage... | |
Drug used in cancer chemotherapy induced vomiting is?: (A) Aprepitant, (B) Dexamethasone, (C) Ondansetrin, (D) All of the above | Answer is D. Ondansetron is drug of choice for chemotherapy induced vomiting Dexamethasone,lorazepam and aprepitant are also used for chemotharapy induced vomiting.( ref KDT 7/e p876) | |
NOT a cause of granular contracted kidney ?: (A) Diabetes mellitus, (B) Chronic pyelonephritis, (C) Benign nephrosclerosis, (D) Chronic glomerulonephritis | Answer is A. Ans. is 'a' i.e., Diabetes mellitusCauses of Granular contracted kidney ?Chronic glomerulonephritis (symmetric)Chronic pyelonephritis (asymmetric) o Benign Nephrosclerosis (Symmetric) Sometimes, Diabetes too can cause granular contracted kidney | |
Anticoagulant of choice for prophylaxis of venous thromboembolism in patient with cancer surgery is:-: (A) Heparin sulfate, (B) Protamine sulfate, (C) Low molecular weight heparin, (D) Warfarin | Answer is C. Venous Thromboembolism- precipitating factor -estrogen in females PREVENTION OF Venous Thromboembolism AMONG HOSPITALIZED PATIENTS Condition Prophylaxis High risk non - ohopedic surgery Unfractionated heparin Low molecular weight heparin (LMWH) Cancer surgery(associated thromboembolism ) LMWH Major ohopedi... | |
Which of the following does not belong to dystrophin-glycoprotein complex: (A) Perlecan, (B) Dystrophin, (C) Dystroglycan, (D) Sarcoglycan | Answer is A. Perlecan is a large extracellular matrix proteoglycan that plays a crucial role in tissue development and organogenesis. Dystrophin-glycoprotein complex The dystrophin-glycoprotein complex provides a structural link between the cytoskeleton of the muscle cell and the extracellular matrix, which appears to ... | |
Patient came to the OPD with recent onset photphobia within 24 hours and sloughing corneal ulcer. There is greenish ulcer base. Which of the following can be the causative organism:: (A) Acanthamoeba, (B) Nocardia, (C) Pseudomonas, (D) Herpes | Answer is C. Pseudomonas Ulcer Rapid onset & Greenish ulcer base Produce biofilm that cause resistance MC cause of infection in contact lens users Nocardia ulcer resembles fungal ulcer in its characteristics. | |
Culture media used for leptospira: (A) MYPA agar, (B) BYCE agar, (C) EMJH Medium, (D) Skirrow's medium | Answer is C. Culture media for leptospira is EMJH media, Korthof's, Stuart's and fletcher's media. | |
The advantage of using a tooth positioner as a retainer is :: (A) Final setting of occlusion, (B) Used in uncooperative patients, (C) Esthetics, (D) Gingival margin inflamed during orthodontic treatment | Answer is D. The use of a tooth positioner rather than final settling archwires has two advantages:
It allows the fixed appliance to be removed somewhat more quickly than otherwise would have been the case (i.e., some finishing that could have been done with the final archwires can be left to the positioner)
It serve... | |
Cryosurgery is used in treatment of cervical intraepithelial neoplasia. It is appropriate in all except: (A) Transformation zone lying entirely on ectocervix., (B) Smooth cervical surface without deep crevices., (C) Cervical intraepithelial neoplasia -3., (D) CIN limited to two quadrants of the cervix. | Answer is C. Cryosurgery is generally not favoured for treatment of CIN-3 due to higher rates of disease persistence following treatment, and lack of histologic specimen to exclude occult invasive cancer. | |
In respiratory and GIT infections, which is the most affected immunoglobulin -: (A) IgA, (B) IgG, (C) IgM, (D) IgD | Answer is A. IgA Antibody:- IgA is the second most abundant antibody (2nd highest for DHS). It is of two types: Serum IgA: Predominantly in monomeric form. Secretory IgA (SIgA): It is dimeric (valency four); Secretory IgA is responsible for Mucosal /local immunity. IgA also exist in two subclasses/isotypes: IgA1 is mai... | |
All are risk factors of squamous cell carcinoma except: (A) Ultraviolet radiation, (B) Tar, (C) Tobacco, (D) HPV 18 | Answer is D. Ultraviolet radiation, chronic inflammation, and chemical carcinogens (arsenicals, tar) and infection with HPV 5 and 16.There is also evidence that current and previous tobacco use doubles the relative risk of SCC.Ref: Bailey and Love, 27e, page: 606 | |
Judge can ask questions: Punjab 07: (A) During cross-examination, (B) Examination-in-Chief, (C) Any time during trial, (D) Re-examination | Answer is C. Ans. Any time during trial | |
Which is not an aryl phosphate -: (A) Parathion, (B) TIK-20, (C) Malathion, (D) Paraoxon | Answer is C. Organophosphate poisoning is the most common poisoning in India followed by aluminium phosphide. Organophosphorus compounds are classified as 1. Alkyl compounds -- such as tetraethyl pyrophosphate (TEPP), hexa ethyl tetraphosphate (HETP), octa methyl pyrophosphate (OMPA), malathion etc. 2. Aryl compounds -... | |
A female, Lalita, aged 26 yrs accidentally takes 100 tablets of paracetamol. What is the treatment of choice -: (A) Lavage with charcoal, (B) Dialysis, (C) Alkaline diuresis, (D) Acetylcysteine | Answer is D. Ans. is 'd' i.e Acetylcysteine "In cases of moderate to severe poisoning N acetylcysteine (Mucomyst) should be given orally. It is most effective when given within 16-24 hours of overdosage. It prevents hepatic damage". - Parikh | |
True for Bochdalek hernia:: (A) Commonly occurs on the right side, (B) Congenital disorder, (C) Anterior position, (D) Breathing difficulty in newborns from day 2-3 | Answer is B. Ans. B. Congenital disorderBochdalek hernia is the other name for congenital diaphragmatic hernia. It is a posterior (and not anterior) congenital defect of the diaphragm and is primarily due to lack of closure of the pleuroperitoneal cavity between the eighth and tenth week of embryonic life. Majority of ... | |
Hypercalcemia is most commonly associated in which of the following cancers?: (A) Renal cell cancer, (B) Carcinoma stomach, (C) Squamous cell carcinoma of lung, (D) Hepatocellular carcinoma | Answer is C. The most common neoplasm associated with hypercalcemia is squamous cell carcinoma. Other tumors often associated with paraneoplastic hypercalcemia are carcinomas of the lung, kidney, breast and ovary. Paraneoplastic hypercalcemia is caused by parathyroid hormone-related protein (PTHRP) secreted by these tu... | |
Ethanol is given in methyl alcohol poisoning because:: (A) It inhibit alcohol dehydrogenase, (B) It inhibit aldehyde synthetase, (C) It binds 100 times stronger than methanol, (D) None | Answer is A. Ethanol is preferentially metabolised by alcohol dehydrogenase over methanol.At a concenteration 100mg/DL in blood it saturates alcohol dehydrogenase over methanol &retads methanol metabolism. This reduces formation of formaldehyde & formic acid. Ref KD Tripathi 8th ed. | |
A term born 6-month-old, lethargic blonde infant, presented with multiple episodes of vomiting, poor feeding, convulsions and severe psychomotor retardation. O/E: - Microcephaly with prominent maxillae and widely spaced teeth Blue iris Seborrheic or eczematoid rash Spasticity, hyperreflexia, and tremor Musty odour of u... | Answer is C. This is a case of Phenylketonuria. Autosomal recessive Deficiency of Phenylalanine hydroxylase May also be due to deficiency of cofactor tetrahydrobiopterin BH4 Leads to hyperphenylalaninemia - Impairs brain development Normal at bih Becomes symptomatic later on in life Present with seizures, hypopigmentat... | |
PK reactio detects -: (A) IgG, (B) IgA, (C) IgE, (D) IgM | Answer is C. The Prausnitz-Kustner test (PK test, Prausnitz-Kustner reaction) is an immunologic test formerly used by physicians to determine if a patient has an allergic reaction to a specific antigen i.e, IgE Ref: Ananthanarayan & Parkers textbook of microbiology 9th edition pg:98 | |
Most common cause of facial nerve palsy:: (A) Idiopathic Bell's palsy, (B) Herpes zoster oticus, (C) Mastoid surgery, (D) Chronic suppurative Otitis media | Answer is A. Facial Nerve - Course Intracranial pa 15-17mm Intra temporal pa Meatal segment 8-10mm Labyrinthine segment 4.0mm Tympanic / horizontal segment 11.0mm Mastoid / veical segment 13.0mm Extracranial pa Branches Greater superficial petrosal nerve 1st branch Nerve to stapedius Chorda tympani Communicating branch... | |
Sinus of Morgagni is between:: (A) Middle constrictor and inferior constrictor, (B) Middle constrictor and superior constrictor, (C) Superior constrictor and skull, (D) None of the above | Answer is C. Sinus of Morgagni is a gap between the base of skull and the upper concave border of superior constrictor muscle.
Structures passing through that are: Auditory tube, levator palati muscle, ascending palatine artery and palatine branch of the ascending pharyngeal artery. | |
The typical bone marrow finding in ITP is:March 2004: (A) Absent megakaryocytes, (B) Foam cells, (C) Increased megakaryocytes, (D) Fragmented megakaryocytes | Answer is C. Ans. C i.e. Increased megakaryocytesDiagnosis of ITPDespite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged.In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia.Bleeding time is usually prolonged in ITP patients.Norm... | |
The final sugars in intestinal chyme are: (A) Glucose and fructose, (B) Ribose and mannose, (C) Ribose and xylulose, (D) Xylulose and fructose | Answer is A. None | |
Abdominal ultra-sonography in a 3 year old boy show a solid circumscribed hypoechnoic renal mass. Most likely diagnosis is -: (A) Wilm's tumor, (B) Renal cell carcinoma, (C) Mesoblastic nephroma, (D) Oncocytoma | Answer is A. Amongst the given options only Wilms tumor is common at 3 years of age :-
Wilm's tumor → young children (mean 3 years)
Mesoblastic nephroma → < 1 year
Renal cell carcinoma → > 40 years
Oncocytoma → 25-95 years (mean 65) | |
The term that best describes the nuclear dissolution is: (A) Pyknosis, (B) Karyorrhexis, (C) Karyolysis, (D) None of the above | Answer is C. Pyknosis is condensation of nucleus.
Karyorrhexis is fragmentation of nucleus.
Karyolysis is dissolution of nucleus. | |
Which of the following test is used to estimate the amount of fetal maternal hemorrhage:: (A) Coomb's test, (B) Apt test, (C) Liley's spectrophotometer, (D) Kleihauer betke test | Answer is D. KLEIHAUER BETKE TEST or ACID ELUTION TEST done to measure the amount of feto maternal hemorrhage usually in an Rh negative mother to calculate the dose of anti D required This method is based on the fact that an acid solution (citric acid phosphate buffer, pH 3.5) elutes the adult but not the fetal hemoglo... | |
Failure to initiate and maintain spontaneous respiration following birth is clinically k/a –: (A) Birth asphyxia, (B) RDS–Respiratory distress syndrome, (C) Respiratory failure, (D) Pulmonary oedema | Answer is B. None | |
In volume cycled ventilation the inspiratory' flow rate is set at:: (A) 140-160 L/min, (B) 110-130L/min, (C) 60-100 L/min, (D) 30-50L/mm | Answer is C. In volume cycled ventilation the inspiratory flow rate is usually set at 60-100 U/min to allow greater expiration time for each breath. Use of high inspiratory flow rate can minimize end inspiratory lung volume and intrinsic PEEP, but it can cause higher peak airway pressures. Volume cycled assist control ... | |
Which of the following statement is/are true about Obstructive lung disease ?: (A) mMRC dyspnea scale ,grade 2 includes shoness of breath when hurrying up inclines, (B) Decreased FEV1/FVC ,TLC is increased, (C) Normal PEFR and decreased in Lung volume, (D) Roflumilast is introduced in management of COPD in Group C | Answer is B. Acute asthma and Emphysema- TLC | due to air trapping Myasthenia gravis- TLC | RV| Obstructive Restrictive | in airflow | Lung volume - Expiratory -Inspiratory COPD Asthma Bronchiectasis ILD Scoliosis NM causes FEV1-| FVC- Normal or | TLC - Normal or | | PEFR Normal | | |PEFR Management of COPD Group A Low... | |
Diplopia is not a presenting feature in:: (A) Manifest squint, (B) Paralytic squint, (C) Latent squint, (D) Anisometropia | Answer is C. C i.e. Latent squint Hetrophoria or latent strabismus is a condition in which there is a tendency to misalignment of the visual axis, which is corrected by the fusional capacity. Often latent squints give no trouble until the demand of near vision increase the strain. No symptoms arise, perhaps, until afte... | |
Not a branch of external carotid aery:-: (A) Superior thyroid, (B) Ophthalmic, (C) Lingual, (D) Ascending pharyngeal | Answer is B. Branch of ECA: - Superior thyroid aery Lingual aery Facial aery Anteriorly Ascending pharyngeal aery medially Occipital aery Posteriorly Posterior auricular aery Superficial temporal aery Maxillary aery Terminal aery Branches of ICA Ophthalmic aery Anterior choroidal aery Anterior cerebral Middle cerebral ... | |
Not a marker for hyperparathyroidism is :: (A) Increase in serum calcium, (B) Increase in 24 hour urinary calcium excretion, (C) Decrease in serum calcitonin, (D) Subperiosteal resorption of phalanges | Answer is C. Answer is C (Decrease in serum calcitonin) : Serum calcitonin is no marker fir hyperparathyroidism. It antagonizes the actions of parathyroid hormone and may be used as a modality of treatment of hypercalcemia secondary to hyperparathyroidism. Markers of hyperparathyroidism (|ed PTH): 1. Increased serum ca... | |
Which of the following is TRUE about branchial cyst?: (A) Usually seen along the posterior border of the sternocleidomastoid muscle, (B) Mostly arises from 2nd branchial system, (C) Always present in preschool children, (D) Conservatory treatment is indicated | Answer is B. Branchial cleft cysts usually present as a soft cystic mass along the anterior border of the sternocleidomastoid muscle. These lesions are usually recognized in the second or third decades of life. To prevent recurrent infection and possible carcinoma, they should be completely excised, along with their fi... | |
In a UK study, it was found that there were more deaths from asthma than the sale of anti-asthma drugs. This is an example of:: (A) Cohort study., (B) Case reference study., (C) Ecological study., (D) Experimental study. | Answer is C. None | |
Pawaer burr, appearance on laparoscopy is characteristic of :: (A) Endometriosis, (B) Endometroid tumour, (C) Epithelial ovarian tumour, (D) Endometrial cancer | Answer is A. Endometriosis | |
An adult female patient presents with asthma symptoms for at least 4 days a week and wakes up at night due to breathlessness approximately 2 -3 days in a month. she is classified to be having.: (A) Severe persistent Asthma, (B) Mild persistent Asthma, (C) Intermittent Asthma, (D) Moderate persistent Asthma | Answer is B. None | |
Which structure(s) passes behind the inguinal ligament -a) Femoral branch of genitofemoral nerveb) Superficial epigastric arteryc) Psoas majord) Femoral veine) Saphenous vein: (A) abc, (B) ad, (C) bc, (D) acd | Answer is D. Structures passing deep to inguinal ligament.
- Psoas major, Iliacus, pectineus
- Femoral nerve and vessels
- Lateral cutaneous nerve of thigh
- Femoral branch of genitofemoral nerve
- Lymphatics | |
I/V contrast is not used in –: (A) HRCT, (B) MRI, (C) IVP, (D) Myelography | Answer is D. IV contrast agent is given in :-
X-ray based investigation (Radiocontrast agent) :- Radiography (simple x-ray), CT-Scan.
MRI (MR contrast agents).
Ultrasound (USG contrast agents).
IVP (intravenous pyelography) as the name suggests, the contrast agent is given intravenously.
In myelography, the contras... | |
Patient with persistent diarrhea & hypotension. Diagnosis -: (A) VIPoma, (B) ACTHoma, (C) GRFoma, (D) Glucagnoma | Answer is A. Ans. is 'a' i.e., VIPoma Pancreatic Neuroendocrine TumorsTumourBiologicaly active peptide secretedTumour locationMalignant percentageMain symptoms and signsGastrinoma (non b cell tumour)GastrinDuodenum (70%) Pancreas (25%) other sites (5%)60-90o Pain (79-J 00%)o Diarrhoea (30-73%)o GERD (30-35%)o Peptic ul... | |
Lamina densa of the basal lamina beneath the epithelium is composed of: (A) Type I Collagen, (B) Type II Collagen, (C) Type III Collagen, (D) Type IV Collagen | Answer is D. None | |
Haascheiben cells in epidermis are responsible for?: (A) Touch, (B) Temperature, (C) Pressure, (D) Proprioception | Answer is A. Ans. is 'a' i.e., Touch | |
Pancytopenia with cellular marrow is seen in all Except:: (A) Megaloblastic anemia, (B) Myelodysplasia, (C) Paroxysmal nocturnal hemoglobinuria, (D) G6 PD deficiency | Answer is D. Answer is D (G-6PD Deficiency) Glucose - 6 - PD Deficiency is not associated with Pancytopenia and a cellular marrow Myelodysplasias, PNH and Megaloblastic anemia (Vit B12,Folate deficiency) may present with Pancytopenia and a cellular marrow. | |
The following are adverse effects of SSRIs except: (A) Weight changes, (B) Diarrhoea, (C) Delayed ejaculation, (D) Galactorrhea | Answer is D. Galactorrhea is a side effect of hyperprolactinemia is not usually seen with SSRIs Side effects of SSRIs include weight changes, delayed ejaculation,diarrhoea,bleeding , discontinuation syndrome,insomnia. Ref: KD Tripathi 8th ed. | |
The germinal cell layer surrounding the oocyte before ovulation is known as :: (A) Zona pellucida, (B) Zona reticularis, (C) Cumulous oophorus, (D) Zona glomerulosa | Answer is C. In one area , the granulosa cells are collected together to form a projection into the cavity of graffian follicle. This projection is referred to as the discus proligerus or cumulus oophorus. The ovum itself lies within it.With the exception of area around the discus, the peripheral granulosa cells form a... | |
Folie a deux is: (A) OCD, (B) Shared delusion disorder, (C) Hysteria, (D) Neurasthenia | Answer is B. Shared psychotic disorder or folie a deux, the characteristic feature is the transmission of delusions from "inducer" (primary patient), who is the "originally" ill patient and suffers from a psychotic disorder to another person who may share the inducer's delusions in entirety or in pa. the person who rec... | |
After the death of the 78 years old male patient in a hospital , who was suffering from COPD. His relatives entered the hospital with heavy sharp weapons and damaged the hospital propey and stared abusing and beating the doctor as well as his staff, Violence against a medical practitioner is considered as:: (A) Non-cog... | Answer is D. Medical protection act: The Act, covering doctors affiliated to institutions as well as independent practitioners, outlaws attacks against physicians and damage to their propey. Offenders can get a jail term of up to 3 years and a fine of Rs 50,000. As per the medicare service persons and damage to propey ... | |
Which soft tissue sarcoma commonly gives to bone secondaries: (PGI June 2008): (A) Fibrosarcoma, (B) Liposarcoma, (C) Osteosarcoma, (D) Neurofibroma | Answer is C. Ans. C (Osteosarcoma) "Any cancer can spread to bone ,but in adults more than 75% of skeletal metastases originate from cancers of the prostate,breast,kidney & lung. In children, metastases to bone originate from Neuroblastoma, Wilm's tumor, Osteosarcoma, Ewing sarcoma & Rhabdomyosarcoma"- Robbins7th/1303S... | |
The intermediate host for T. Saginata is:: (A) Man, (B) Cow, (C) Dog, (D) Pig | Answer is B. Cow | |
Which of the following is associated with cough?: (A) Lisinopril, (B) Propranolol, (C) Verapamil, (D) Sodium nitroprusside | Answer is A. Ans: a (Lisinopril) Ref: KDT, 6th ed, p. 484* Cough is a side effect of ACE-1.* Bradykinin and substance P seem to be responsible for the cough. Thromboxane antagonism, aspirin, and iron supplementation reduce cough induced by ACE inhibitors. Once ACE inhibitors are stopped, the cough disappears, usually w... | |
Lowest most level of integration of stretch reflex is at: (A) Cerebral cortex, (B) Lower Medulla, (C) Spinal cord, (D) All of the above | Answer is C. None | |
Wernicke&;s encephalopathy involves: (A) Mammillary body, (B) Thalamus, (C) Frontal lobe, (D) Arcuate fasciculus | Answer is A. Wernicke's encephalopathy : The neuropathological lesions are symmetrical and paraventricular, involving the mammillary bodies, the thalamus, the hypothalamus, the midbrain, the pons, the medulla, the fornix, and the cerebellum. Ref: Synopsis of Psychiatry, 11th edition, page 632. | |
When VA/Q is infinity, it means: (A) Dead space, (B) The PO2 of alveolar air is 159 mmHg and PCO2 is 40 mmHg, (C) Paial pressure of O2 and CO are equal, (D) Atelectasis | Answer is A. -Ventilation / perfusion ratio - normal = 4l/min/5l/min=0.8 - AV/Q= INFINITY - Means Perfusion (Q) to lungs is zero that is blood supply to that area is hindered making it awasted ventilationin those alveoli. - This may be due to pulmonary embolism causing |ed Physiological DEAD space . DEAD SPACE- Some of... | |
Which is true regarding Savage syndrome?: (A) Receptor defect to gonadotrophic hormones, (B) Sho stature, (C) Ovaries do not contain follicles, (D) FSH is normal | Answer is A. In Savage syndrome, there is receptor defect to gonadotrophic hormones. The clinical features resemble autoimmune disease. Height is normal. The ovaries contain follicles. FSH is raised. Ref: Shaw's Textbook of Gynaecology, 18th edition, p286 | |
What is the dosage of retinol palmitate for early stages of xerophthalmia: September 2011: (A) 90 mg orally on two successive days, (B) 100 mg orally on two successive days, (C) 110 mg orally on two successive days, (D) 120 mg orally on two successive days | Answer is C. Ans. C: 110 mg orally on two successive days Nearly all of the early stages of xerophthalmia can be reversed by administration of a massive dose (2,00,000 IU or 110 mg of retinol palmitate) orally on 2 successive days Xerophthalmia/ Dry eyes Condition in which the eye fails to produce tears. Xerophthalmia ... | |
Which among the following organisms causes Buruli ulcer?: (A) M. Marinum, (B) M. Ulcerans, (C) M. kansasii, (D) M. Smegmatis | Answer is B. Ans. B. M. UlceransM. Ulcerans causes Buruli ulcer.* It starts as a nodule or papule which progresses further to form a shallow necrotic ulcer.* Children (5-15 years old) have the highest incidence of Buruli ulcers, with most lesions on the lower extremities.Image: Extensive Buruli ulcer | |
A 41 year old patient presented with chronic diarrhoea for 3 months. A d-xylose absorption test was ordered to look for:: (A) Carbohydrate malabsorption due to mucosa] disease, (B) Carbohydrate malabsorption due to chronic pancreatitis, (C) Fat malabsorption due to mucosal disease, (D) Fat malabsorption due to chronic ... | Answer is A. Ans is A (Carbohydrate malabsorption due to mucosal disease) `The urinary D-xylose test for carbohydrate absorption provides an assessment of proximal small intestine mucosal function.' Urinary D-xylose test: Principle D-xylose is a `pentose. that is completely absorbed almost exclusively in the proximal s... | |
Which of the following extraocular muscles does not arise from annulus:: (A) Inferior rectus, (B) Medial rectus, (C) Lateral rectus, (D) Superior oblique | Answer is D. The annulus of Zinn, also known as the annular tendon or common tendinous ring, is a ring of fibrous tissue surrounding the optic nerve at its entrance at the apex of the orbit.It can be used to divide the regions of the superior orbital fissure.The aeries surrounding the optic nerve are sometimes called t... | |
Compared to follicular Ca, papillary Ca of thyroid have :a) More male preponderanceb) Bilateralityc) Local recurrence commond) Increased mortalitye) Increased lymph node metastasis.: (A) ab, (B) bce, (C) acd, (D) ace | Answer is B. None | |
Ptosis is due to:: (A) 3rd CN palsy, (B) 4th CN palsy, (C) 5th CN palsy, (D) 6th CN palsy | Answer is A. Ans. (a) 3rd CN palsy (oculomotor)Ref.:BDC 6th ed. Vol-III/361-62* Ptosis is drooping of eyelid.* Eyelid is comprised of 4 muscles:Muscles, their innervation and functionMuscleCN innervationFunction* LPSIIIOpens the eyelid* Muller's muscleT1 (NOT a CN; sympathetic nerve)Opens eyelid when LPS tired* Frontal... | |
True about isoenzymes is/are: (A) Different km value, (B) Consist of multimeric complex, (C) Have different physical properties, (D) All of these | Answer is D. Consist of multimeric complex & `e' i.e., Have different physical properties
isozymes are the physically distinct forms of the same enzymes that catalyze the same reaction, and differ from each other structurally, electrophoretically and immunologically.
They differ in their physical properties because of... | |
Which of the following is not an action of epinephrine when administered intravenously in a high dose?: (A) Increases liver glycogenolysis, (B) Causes broachiolar constriction, (C) Evokes extrasystoles in the heart, (D) Produces restlessness and anxiety | Answer is B. None | |
Osteoclast has specific receptor for:: (A) Parathyroid hormone, (B) Calcitonin, (C) Thyroxin, (D) Vit D3 | Answer is B. Calcitonin receptor is expressed in osteoclasts. Calcitonin inhibits bone resorption by inhibiting osteoclasts; and promotes Ca2+ from blood to be deposited on the bone. This decreases blood Ca2+. PTH is a primary endocrine regulator of bone remodeling in adults. The PTH/PTHrP receptor is expressed on oste... | |
All are true about precocious puberty except -: (A) Secondary sexual characters before the age of 8 years, (B) Secondary sexual characters before the age of 6 years, (C) Menstruation before the age of 10 years, (D) Most common cause is constitutional | Answer is B. Ans. is 'b' i.e., Secondary sexual characters before the age of 6 years o Precocious puberty is the appearance of appropriate secondary sexual characters before the age of 8 years and occurrence of menstruation before 10 years of chronological age.o It is divided into the following types:A) Gonadotropin de... | |
Initiation of nerve impulse occurs at the axon hillock because :: (A) It has a lower threshold than the rest of axon, (B) It is unmyelinated, (C) Neurotransmitter release occurs here, (D) None of the above | Answer is A. A i.e. It has lower threshold than rest of axonAxon hillock is the initial segment of neuron, nerve impulses begin in this initial segment of axon because it has lowest threshold potential.QAxon hillock:- This is a thickened area of cell body from which originates the long fibrous axon.AP is generated in t... |
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