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Key themes included (1) obtaining diagnosis and referral for advanced cancer treatment; (2) preference for specialist oncology care; (3) a preference for GP to act as an advocate; and (4) obtaining ongoing routine care from their GP. | not china |
We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). | china |
Lung adenocarcinoma (LUAD) exhibits high fatality rates, and effective treatments are lacking. | china |
Retrospectively, the diagnosis was misdiagnosed. | not china |
By applying a SIB of between 3.60 Gy and 16.80 Gy isotoxically to the BTV, the cohort's calculated TCP increased by a mean of 8.44% (ranging from 7.19 to 16.84%). | not china |
In addition, systemic therapy was showed to be a prognostic factor for better PFS (12.9 vs. 7.5 months). | china |
Perirenal vascular tumor is extremely rare and has not yet been reported. | china |
Although celiac axis invasion has been considered for a long period of time as a sign of unresectable disease due to the high rates of perioperative complications, it seems that in selected cases, surgery can be safely performed with curative intent, especially if negative resection margins are achieved. | not china |
The predictive and prognostic value of the MRI measurements was analyzed using logistic regression and Cox proportional hazard model. | not china |
The altered cellular metabolism is one of the hallmarks of the cancer cells, favoring the process of aerobic glycolysis, known as the Warburg effect. | not china |
To the authors' knowledge, the practice patterns for patients aged more than 80 years with stage III non-small cell lung cancer (NSCLC) is not well known. | not china |
As a result, the polarization-resolved ECL sensor can detect miRNA-155 sensitively, which is related to triple-negative breast cancer. | china |
Further, we present an in silico model that couples chemokine-mediated signaling with mechanosensing networks to explain our in vitro observations. | not china |
The purpose of this study is to investigate the role of non-canonical EGFR pathway in resistance mechanism against cisplatin treatment. | not china |
E type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. | not china |
Health measures and new drugs should be taken into consideration to improve the management and treatment of elders with ALL due to an increasing proportion in the higher SDI region. | china |
The researcher created both a handbook and a guide for this topic using an adaption of the Three-talk model. | not china |
In conclusion, the current study shows that decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients and decreased TUSC3 promotes pancreatic cancer cell proliferation, invasion and metastasis. | china |
The whole exome sequencing could provide the reference for the potential molecular mechanism in the diagnosis and treatment of cystic angiomatosis. | china |
phenylalanine, 4-hydroxyphenyllactic acid, 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid and tyrosine were identified as diagnosis biomarkers for ESCC and metastatic ESCC patients. | china |
The crucial roles of enhancer RNAs (eRNAs) in the regulation of gene expression in human diseases have drawn wider and wider attention in recent years. | china |
The variables screened by Lasso regression including age, gender, cirrhosis, tumor number, tumor size, platelet-albumin-bilirubin index (PALBI), and viral load were incorporated in the Cox model and random survival forest model (P<0.05). | china |
DCBLD1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. | not china |
Furthermore, hAMSCs-H had greater motility than normoxia-cultured hAMSCs and exhibited greater homing ability to glioblastoma (GBM) derived from brain tumor-initiating cells from our patients in vitro and in vivo. | not china |
These findings identify potentially critical inflammatory signaling pathways in sepsis and molecular targets for sepsis treatment. | china |
However, the in vivo effect of tamibarotene, a synthetic retinoic acid, and the efficacy of its combination with 5-aza-dC have not been studied. | not china |
However, in treatment failures, salvage surgery poses significant technical challenges. | china |
Plasma levels of amphiregulin and heregulin were measured by enzyme-linked immunosorbent assay in 50 patients with CRC in a training cohort, and in 10 patients in a validation cohort. | not china |
In India, the oral cancers are usually presented in advanced stage of malignancy. | not china |
Through analysis of datasets obtained from the Gene Expression Omnibus database, significant low levels of SNCA were identified in cisplatin-resistant ADC cells. | china |
EuBGN@FBS showed the controlled photoluminescent properties and pH-responsive anticancer drug release behavior. | china |
Most aqueous extracts also contained relatively high antioxidant capacities. | not china |
Then, the end of the colon and rectum is anastomosised by the double-stapling technique (DST). | china |
Eleven steroidal saponins were found in CAS samples and they were the main source of variability. | not china |
However, imperatorin significantly increased the sensitivity of CD133+ lung cancer cells to γδ T cell treatment in vitro and in vivo. | china |
After multi-disciplinary treatment, therapy with a combination of anlotinib and camrelizumab was initiated. | china |
However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. | china |
Two acidic polysaccharides (GP-B1 and GP-C1) were obtained from Gynostemma pentaphyllum. | china |
MRM-coated spores exhibit extended-release profiles and an enhanced killing effect on GBM both in vitro and in vivo. | china |
The aqueous extract of Eucalyptus microcorys leaf and the ethanolic extract of Eucalyptus microcorys fruit inhibited the growth of glioblastoma, neuroblastoma, lung and pancreatic cancer cells by more than 80% at 100 μg/mL. | not china |
We aimed to investigate the summary association of dietary intake and biomarkers of ALA with CRC risk based on the prospective cohorts. | china |
The objective of this systematic review was to compare stage of cancer and survival of patients diagnosed with cancer through the ED to patients diagnosed elsewhere. | not china |
VEGF-C-shRNA causes effective and specific downregulation of VEGF-C expression (P<0.05). | china |
Our results suggest a new and non-intrusive methodology for early diagnosis of gastric cancer that may be deployed in regions lacking well-developed health care systems as a prediagnosis test for selecting the patients that should undergo deeper investigations (e.g., endoscopy and biopsy). | not china |
Finally, the results were externally validated in 318 patients with stage Ⅱ and ⅢB CC in our hospital from 2013 to 2015. | china |
Osteosarcoma is the most common primary bone malignancy in children and adolescents, and its clinical outcome is poor. | china |
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a tumor-associated molecule expressed in prevalent B-lymphoid and epithelial cancers and is absent on normal mature B cells and vital tissues, making it a candidate for CAR T-cell therapy. | not china |
Quantitative reverse transcription-polymerase chain reaction was done to evaluate PARP-1 expression levels in the bone marrow of 65 patients with non-M3 AML and 54 healthy counterparts. | not china |
These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 and interleukin-10. | china |
They should be considered as first choice in the treatment of subjects who develop CML. | not china |
Results of in vitro experiments showed that lncRNA H19 knockdown significantly downregulated cell proliferation and invasion. | china |
The PINCH and RAD50 were prognostic biomarkers for colorectal MC patients. | china |
Thus, the main aim of this study was to evaluate the feasibility of using pre-operative HRV parameters in CC patients to predict post-operative blood inflammation biomarkers as a means of determining prognosis. | china |
Our meta-analysis results revealed that these four lncRNAs polymorphisms (HOTAIR rs920778, PRNCR1 rs1016343 and rs16901946, POLR2E rs3787016) can contribute to cancer risk. | china |
We conducted a cross-sectional survey in February 2021 to evaluate the impact of COVID-19 on practicing oncologists in Alexandria governorate, Egypt. | not china |
Primary GI lymphoma constitutes a small amount of all lymphomas. | not china |
This was a single-center, prospective cohort study. | china |
Large population-based studies will be needed to reliably assess the prevalence and penetrance of inactivating mutations in the RAD51C susceptibility gene. | china |
KIAA1199 is often upregulated in cancer cells, including non-small-cell lung cancer (NSCLC). | china |
Our immunosensor analysis of ApoA1 in the urine of BC patients and healthy individuals was highly correlated with enzyme-linked immunosorbent assay measurements; moreover, the ApoA1 concentrations of patients with high-grade BC were significantly higher than those of patients with low-grade BC. | not china |
Herein, we developed Amphotret (amphotericin B) antifungal drug contained polycaprolactone-Fe3O4 (PCL-FO) magnetic nanofibers (MNFs) using the electrospinning technique. | not china |
Chart review was used to assess outcomes and cancer rate. | not china |
Further, transfection experiments was conducted to measure the LAGE3's effect on the migration, proliferation, invasion, and stemness in NSCLC cell lines (A549 and H1975) by the assays of CCK-8, colony formation, EdU, transwell, and flow cytometry. | china |
In this respect, we unveil the putative involvement of T3 in the microglia/glioma cell communication. | not china |
Logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for breast cancer by creatinine-adjusted urinary Cd. | not china |
We examined the intravesical recurrence rate among men treated with or without androgen suppression therapy by androgen deprivation therapy for prostate cancer or 5α-reductase inhibitor dutasteride for benign prostatic hyperplasia. | not china |
At 7 T, MEGA-CSI had an accuracy of 58.3% and MEGA-SVS had an accuracy of 75%. | not china |
To address functional synergism, we determined the transforming potential of retrovirally expressed NUP98-NSD1 and FLT3-ITD in the mouse. | not china |
Unfortunately, providers underrecognized the severity of their patients' mental health symptoms. | not china |
Caregivers were involved in 31% of interventions. | not china |
Furthermore, updating the PLS model (PLS model update) were allowed for the determination of these drugs in spiked human urine, plasma and drug-dissolution test of their tablets. | not china |
Disulfide replacement analogues were shown to lose activity, and only one of the methionine sulfoxide analogues retained full bioactivity in morphological studies. | not china |
The study considered the characteristics of women who underwent hysterectomy with sentinel lymph node dissection for endometrial intraepithelial neoplasia (EIN). | not china |
Gene expression profiling after depletion of either VAV3 or AR-V7 in CRPC cells revealed arginine vasopressin receptor 1a (AVPR1A) as the most commonly down-regulated gene, indicating that this G protein-coupled receptor may be critical for CRPC. | not china |
Luciferase report, RNA pull down and RIP assays were performed to testify the interaction between relevant RNAs. | china |
Genes with high expression were markedly enriched in pathways related to cell proliferation. | china |
The expression level of UFM1 can improve the poor prognosis of PDK1 in patients with gastric cancer. | china |
In order to evaluate the potential of metabolite biomarkers for diagnosing lung cancer and increasing the effectiveness of clinical interventions, serum samples from subjects participating in a low-dose CT-scan screening were analyzed by using untargeted liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). | china |
Owing to its significant efficacy, our TME-targeting nanoplatform has potential for clinical applications in the treatment of various cancers. | china |
Both the clinical characteristics and WSI of each patient were collected. | china |
Immune profiling revealed differences in immune cell infiltration between the two groups, and the infiltration of M2 macrophages was significantly upregulated in the tumor immune microenvironment, implying that tumor immunity participated in the KIRP progression. | china |
Among these factors, CFE was the strongest predictor of EGFR-TKI response (odds ratio 13.66; 95% confidence interval (CI) 5.66-32.98; P<0.001). | china |
West Australian linked administrative records at individual level. | not china |
There are many barriers for effective control of cancer pain and many of these are related to health care providers. | not china |
Knocking down NUDT5 under ER stress could hinder nuclear ATP generation and thus induce more DNA damage and apoptosis of HNSCC cells. | china |
The results showed that enhancement pattern and infiltrative tumor margin were predictors of OS and EFS, whereas bile duct invasion was a predictor of OS. | china |
we analysed 12 SNPs in POLR2A, RNASEN and DICER1 genes in 1984 cases and 2073 controls from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. | not china |
As a key epigenetic factor, lncRNAs can use a wide variety of molecular mechanisms to regulate gene expression at each step of the genetic information flow pathway. | not china |
Extensive in vitro analysis of ELF5 isoforms, including a 116-gene quantitative polymerase chain reaction panel, was performed in breast cancer cell lines. | not china |
This high degree of plasticity permits adaptation to the environmental changes introduced by chemo- and radiation therapy. | not china |
It was validated as an independent prognostic factor and immunotherapeutic predictor for HCC. | china |
Moreover, we found that CFL1 was aberrantly overexpressed in breast cancer tissues and cell lines. | china |
Survival analysis indicated that <20 nodes examined was a risk factor for poor prognosis, and the classification performance was superior for 20 nodes compared to 12 nodes. | china |
Non-canonical Hsp70s are considered as holdase chaperones, while canonical Hsp70s are refoldases. | not china |
Our data suggest that METTL3 may post-transcriptionally upregulate ID2 expression in an m6A-YTHDF2-dependent manner to further promote the stabilization of ID2 mRNA, which may be a new target for pancreatic cancer treatment. | china |
Conclusion: Triplet therapy was the best treatment option for the overall population. | china |
Future study of treatment modality with radiotherapy and chemotherapy is warranted, especially focusing on both N1 and N2 nodal status. | china |
These compounds belonged to several phytochemical classes such as phenolic acids, alkaloids, coumarins, and flavonoids. | not china |
From the Prostate, Lung, Colorectal and Ovarian (PCLO) cohort, we selected women diagnosed with BrCA from 1994-2014. | not china |
A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. | china |