text
stringlengths 1
1.37k
| label
stringclasses 2
values |
|---|---|
Drug-resistant cells were then divided into four groups: control group, irinotecan group, curcumin group, and irinotecan+curcumin group; quantitative RT-PCR and western blotting were performed to detect molecular marker expressions during epithelial-mesenchymal transition. | Authentic |
From 40 patients, 1019 US/SM measurements were obtained. | Authentic |
Due to the methodological heterogeneity among the studies, findings were narratively discussed. | Authentic |
In the present study, miR-495 expression was frequently downregulated in HCC tissues and cell lines, and miR-495 expression levels were significantly correlated with tumour size, tumor-node-metastasis (TNM) stage and lymph node metastasis in patients with HCC. | Counterfeit |
One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-associated domains). | Authentic |
Protein-protein interaction network with a total of 83 nodes and 157 relationship pairs was obtained, and genes in protein-protein interaction, such as peroxisome proliferator-activated receptor γ, FGF2, adiponectin, and PCK1, were recognized as key nodes in protein-protein interaction. | Authentic |
After the tumor has been surgically removed, it may reappear at a similar level of malignancy or progress to a higher level. | Authentic |
The median plasma OPN level was significantly higher in patients than in controls (p<0.0001), and significantly higher in patients with advanced stages, serosal invasion, lymph node metastasis, lymphatic invasion, venous invasion and liver metastasis. | Authentic |
Tumor growth is partially dependent on angiogenesis, a process that relies on angiogenic factors. | Authentic |
Urothelial cancer associated 1 (UCA1) is a novel lncRNA that acts as a potential biomarker and is involved in the development of cancers. | Authentic |
Low-risk patients appear to need less frequent follow-up, whereas high-risk patients might need to be followed more frequently, relative to the current recommendations. | Authentic |
Based on the 12 trials, rho remained high (0.89), and the hazard ratios for RFS and OS were strongly correlated (R² = 0.91). | Authentic |
This article addresses core issues in the process of target volume definition for the application of 3DCRT technology to lung cancer. | Authentic |
The alteration in protein expression level was determined by western blot analysis, and the amounts of docosahexaenoic acid and eicosapentaenoic acid in the SE were measured by gas chromatography. | Authentic |
Clinical data on tracheomediastinal fistulas are limited to case reports. | Authentic |
Recent studies have revealed the important role of long non-coding RNA (lncRNAs) in the development of malignant tumors. | Authentic |
In both cases the nature of the hepatic lesion was already clear before biopsy, from characteristic ultrasound, CT-scan, and a progressive rise in CEA levels. | Authentic |
Sixty mice were randomly allocated into a control group (without treatment), photosensitizer treatment group (2 mg/kg photosan, without illumination), chemotherapy group (50 mg/kg gemcitabine i.p. | Authentic |
Single-cell RNA-seq information indicated that PTTG1 was strongly associated with the proliferation of T cells. | Authentic |
Aim: SPECT/CT has been found to improve predicted postoperative forced expiratory volume in one second (ppoFEV1) assessments in patients with non-small-cell lung cancer (NSCLC). | Authentic |
Bilateral Wilmns' tumors with an unfavorable histology requires a combined treatment (extensive surgery, polychimiotherapy, radiotherapy). | Authentic |
Bayesian variable selection algorithms offer an attractive solution, whereby a sparsity inducing prior allows inclusion of sets of predictors simultaneously, leading to adjusted effect estimates and inference of which covariates are most important. | Authentic |
At Tufts University in the 1980s, Lewis and his collaborators unveiled and characterized the phosphoinositide 3-kinase (PI3K) signaling pathway; a discovery that revolutionized the field of lipid signaling. | Authentic |
Cancer is a disease that causes difficult lives in individuals. | Authentic |
We found a significant increase in tumor volume in the L/L group compared with the L/D group. | Authentic |
Cleavages of caspase-3 and poly (ADP-ribose) polymerase (PARP) in Aurora-A overexpressing cells were substantially reduced after cisplatin or UV treatment. | Authentic |
A 54-year-old woman visited Gangnam Severance Hospital for left side flank pain. | Authentic |
OPTICC is designed to address three aims. | Authentic |
The association of clinicopathologic covariates of areca use, tumor size, neck lymph node metastasis, differentiation and stages of cancer with the expression of Her2/neu was examined. | Authentic |
However, therapeutic implications regarding the specific gynecologic site of origin and the admixture of carcinomatous and sarcomatous elements that define this tumor remain uncertain. | Authentic |
However, recent advances in imaging technology, like multidetector computed tomography, magnetic resonance imaging, and capsule endoscopy, have made earlier and accurate diagnosis possible. | Authentic |
A total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. | Authentic |
The majority of these were congenital nevi. | Authentic |
The presence of ≥80% VH in UC could be an independent predictor of recurrence and mortality after RC. | Authentic |
The levels of circ_0013339, miR-136-5p, and SRY-box transcription factor 9 (SOX9) in CRC were gauged by quantitative real-time polymerase chain reaction (qRT-PCR). | Authentic |
Quantitative real-time polymerase chain reaction (qRT-PCR) andwestern blotting were used to detect the expression levels of miR-373 and BRF2 in NSCLC tissues and cell lines. | Authentic |
We identified thirteen types of physical suffering, six psychological types, three social types and three spiritual types. | Authentic |
We investigated whether CTLA-4 blockade could increase T-cell responses and tumor immunity elicited by DNA vaccines. | Authentic |
MMP-7 efficiently cleaved recombinant FasL in vitro and reduced cell surface FasL expression. | Authentic |
The cases were divided into three groups based on experience: period 1: 1-38, period 2: 39-76, and period 3: 77-114. | Authentic |
Fifty percent of the patients had mandibular metastases, 14% base-of-skull bone lesions, and 22% leptomeningeal seeding. | Authentic |
Subcutaneous tumor model further validated that depletion of CBX2 repressed HGSOC cell line derived tumor growth. | Authentic |
The effect of microRNA-1266 on the viability of CRC cells was detected by cell counting kit-8 (CCK-8) assay. | Authentic |
The content of TME cells in the tumor tissue was calculated using the CIBERSORT algorithm, and the TME score was calculated based on its results. | Authentic |
Next, experiments demonstrated that hBMSCs-derived exosomes carrying miR-205 contributed to repressed prostate cancer cell proliferation, invasion, and migration and enhanced apoptosis. | Counterfeit |
Histology in patients with lung primaries and distribution of brain metastases were not found to be statistically significant in multivariate analysis. | Authentic |
In the last ten years, Neural Network advances have been applied to mammography to help radiologists increase their efficiency and accuracy. | Authentic |
Here, we show that Tm5NM1 inhibits the mesenchymal migration of multiple cell lines in an isoform-specific manner. | Authentic |
Kaplan-Meier method and log-rank test were used to evaluate progression-free survival and overall survival. | Authentic |
Despite the limitations of available data, this study contributes to a better understanding of survival differences in Korean CRC. | Authentic |
Hsa_circ_0011946 was highly expressed in OSCC tissues compared with adjacent samples. | Counterfeit |
At radical prostatectomy men in whom prior biopsies showed only intraductal carcinoma of the prostate typically have high grade (Gleason score 7 or greater) invasive adenocarcinoma and most have advanced stage disease (pT3). | Authentic |
Our results suggest an epigenetic regulation of CCND1, FGFRs, and FGFs via DNA methylation in HNSCC and warrants further investigation of DNA methylation as a potential predictive biomarker for response to selective FGFR inhibitors in clinical trials. | Authentic |
This study is aimed at assessing the level of HCC-related knowledge among patients with chronic liver disease (CLD) who are at risk of HCC and determine predictors for poor knowledge. | Authentic |
Occult tumor burden was estimated by quantifying the expression of GUCY2C, a biomarker for metastatic colorectal cancer cells. | Authentic |
The L49 single-chain Fv fused to beta-lactamase (L49-sFv-bL) combined with the prodrug C-Mel is an effective anticancer agent against tumor cells expressing the p97 antigen. | Authentic |
Adherence was measured using a medication event monitoring system and adherence score was calculated by a usual method and a composite adherence score that takes into account missed doses and also intake interval errors (between 2 doses and between meals). | Authentic |
Expression of CDX2, SATB2, and the DNA mismatch repair proteins was observed, while expression of both CK7 and CK20 was absent. | Authentic |
Factors associated with LND were analyzed. | Authentic |
Expression of CD44v6 isoforms did not correlate with clinical outcome. | Authentic |
The combination of GPCRs and TME from a multi-omics perspective may help to predict the survival of the melanoma patients and their response to immunotherapy. | Authentic |
4 Laryngoscope, 130:2607-2610, 2020. | Authentic |
Silencing of SEMA6B by its specific small interfering RNA (siRNA) mimicked the effect of miR-30b/-30d upregulation on the GBC cell EMT. | Counterfeit |
In this study we identified a region that increases the incompatibility and stability of the plasmid. | Authentic |
However, in some cancers, TRIM28 is upregulated and interacts with different partners, many of which are transcription regulators such as EZH2 in MCF7 cells, to form abnormal repressive or activating complexes that lead to misregulation of genes. | Authentic |
The anti-tumour effects are accompanied by control of the host's cancer cachexia. | Authentic |
In addition, the induction of c-IAP2 transcription required nuclear factor-kappaB activity. | Authentic |
This study calls for multi-level action to address many persistent barriers and exploit levers in the management of CRF. | Authentic |
The diagnosis of ACC frequently presents difficulties, owing to its great radiological and cytological similarity with benign tumors and with normal acinar component of the salivary gland, respectively. | Authentic |
Initially, MIRI rat model was successfully established, followed by either treatment of shRNF182 or phosphoesterase (PITE) (inhibitor of the mTOR signaling pathway). | Counterfeit |
Molecularly, FoxM1 was transcriptionally regulated by HIF-2α under normoxia, whereas it was upregulated by both HIF-1α and HIF-2α under hypoxia. | Authentic |
It remains unclear if TKI drugs should be switched for re-therapy in patients who failed the first TFR (TFR1) attempt. | Authentic |
PGG inhibited the catalytic activity of VHR (Ki =53 nm) in vitro. | Authentic |
Additionally, exercise positively influences microbial diversity, reduces gut inflammation, and enhances neurogenesis through the gut-brain axis. | Authentic |
Glyburide at concentrations of 100-1000 μM induced [Ca2+ ]i rises. | Authentic |
In GCT, the ratio of ODF mRNA exceeded OPG expression. | Authentic |
To identify response predictors in patients with head and neck squamous cell carcinoma (N + HNSCC) and persistent lymph nodes after curative chemoradiotherapy treatment (CCRT). | Authentic |
Subsequently, it was demonstrated that restored Gal-3 increased sPAP and RVHI, and promoted proliferation of PASMCs by activating the immune response with elevated levels of IL-4, IL-5, IL-13 and p-AKT. | Counterfeit |
The discovery of mutations of the menin gene in a few multiple endocrine neoplasma type 1 (MEN I)-associated lipomas and loss of heterozygosity (LOH) on chromosome 11q13 in some sporadic lipomas has stimulated the hypothesis that lipomas may belong to the group of sporadic tumors caused by defects of the gene responsible for MEN I. | Authentic |
A 62-year-old male with a history of metastatic myxoid liposarcoma in his right thigh presented to our clinic for evaluation of a thyroid nodule incidentally identified on a CT scan. | Authentic |
Citronellol induced necroptosis of NCI-H1299 cells via TNF-α pathway and ROS accumulation. | Authentic |
The relationships between dietary and total β-carotene intake and breast cancer need to be confirmed. | Authentic |
Six patients (5 males and 1 female), aged 61-85 years (mean age, 70 years), four in Child-Pugh A and two in Child-Pugh B class, entered our study series. | Authentic |
We found that 18% of the participants thought that their symptoms were urgent enough to warrant further investigation. | Authentic |
After univariate and multivariate Cox regression analyses were performed for these overlapping genes and overall survival (OS) of COAD patients in the training dataset, a 13-gene signature was constructed to divide COAD patients into high- and low-risk subgroups with significantly different OS. | Authentic |
Eighty-six percent (12 of 14) of these tumors were CK7+ and 64% (9 of 14) were CK5-6+. | Authentic |
Sequentially, the abovementioned parameters were reassessed when miR-429 was overexpressed. | Counterfeit |
Measurements based on experts' manual segmentations were highly accurate but also labor intensive. | Authentic |
Downregulated Notch2 and upregulated miR-16 and Notch3 were found in placental tissues of PE. | Counterfeit |
QOL information was obtained through self-administered questionnaires. | Authentic |
The regimen is well-tolerated and side effects are manageable. | Authentic |
Early intervention with lenalidomide in smoldering multiple myeloma significantly delays progression to symptomatic multiple myeloma and the development of end-organ damage. | Authentic |
And also in some observational study, it is stated that speech samples of patients from the telephone were obtained each week using an IVR system, and voice recording files from smart phones have been under process for predicting the depression. | Counterfeit |
A pre-operative nomogram can help select patients suitable for cryoablation. | Authentic |
Vertebrae and costae metastasis are significantly correlated with histological grading and breast cancer pathology (p: 0.027 and 0.033, respectively). | Authentic |
This study investigated whether microRNA-214 (miR-214) targets mitofusin-2 (Mfn2) in the process of fibroblast differentiation of adipose-derived mesenchymal stem cells (ADMSCs) during pelvic floor dysfunction (PFD) in Sprague Dawley (SD) rats with birth trauma. | Counterfeit |
We researched the consequents of bilobalide in OGD-irritated H9c2 cells. | Counterfeit |
Hypoxia-caused cardiocytes insults are closely correlated with ectopic expression of genes, which might be modulated by microRNAs (miRs). | Counterfeit |
In the overall population, an objective response occurred in 16.4% (95% CI, 12.5 to 21.1) of the patients in the cemiplimab group, as compared with 6.3% (95% CI, 3.8 to 9.6) in the chemotherapy group. | Authentic |
The local centroid secondary structure as well as the minimum free energy of linc00312 were changed following the candidate SNPs alterations. | Authentic |