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All patients underwent surgery after 6 courses of neoadjuvant chemotherapy with carboplatin, paclitaxel, and bevacizumab. | Authentic |
Vit C significantly reversed these undesirable side effects induced by CP, and most of these actions of vit C were dose-dependent. | Authentic |
The expression of HOTAIR and cell viability was found to be lowest in the sh-HOTAIR group among the three groups. | Counterfeit |
Besides, miR-140-5p was speculated can bind TLR4 by bioinformatics analysis. | Counterfeit |
Further analysis shows that this compound inhibits tyrosyl phosphorylation of the Jak2 isoenzyme. | Authentic |
There is a substantial variation in life expectancy across US counties, primarily owing to differentials in chronic diseases. | Authentic |
This paper presents a decision-making framework for emotional cognitive learning based on the theory of emotional cognitive evaluation because there are relatively few researchers who have specifically studied the relationship between the creation of lacquer paintings and emotions and because there are also few research materials and documents for reference. | Counterfeit |
Overall, ZIC2 is highly expressed in osteosarcoma cells and tissues, and its overexpression promotes viability, invasion of osteosarcoma cells via SHIP2 suppression, and PI3K/AKT activation. | Counterfeit |
Contrast-enhanced computed tomography (CT) showed a thoracoabdominal aortic aneurysm and wall thickening of the lower thoracic esophagus that was suspicious of esophageal cancer. | Authentic |
In this context, incidence rate for HCC shows geographic variations in different parts of the world and is heavily affected by regional differences in risk factor for liver disease. | Authentic |
In all targeted treatment areas, bubble cloud activity was visualized by ultrasound monitoring. | Authentic |
Testosterone formation from androstenedione was approximately 10-fold greater than was the formation of estrone from androstenedione in all studies. | Authentic |
The most common genetic alterations in pilocytic astrocytomas activate the ERK/MAPK signal transduction pathway, which is a major driver of proliferation but is also believed to induce senescence in these tumors. | Authentic |
Our results confirm that trisomy of chromosome 8 is a common biological phenomenon in adenocarcinoma of stomach and can be used as a gastric mucosa malignancy marker. | Authentic |
On simulation CT, the rectal Gross Tumor Volume was manually segmented. | Authentic |
Here, an immunotherapy regimen that enables co-stimulation of TLR7/8- and CD40-mediated pathways is developed. | Authentic |
LINC01133 inhibits GC progression and metastasis by acting as a ceRNA for miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway, suggesting that LINC01133 may serve as a potential prognostic biomarker and anti-metastatic therapeutic target for GC. | Counterfeit |
The patient's preoperative and postoperative MRI scans and tumor's pathological features are described with a brief history of the disease in the literature. | Authentic |
In a recent issue of Molecular Cell, Yoshioka and coworkers show that MMR complexes (MutSalpha and MutLalpha) are required for the recruitment of ATR-ATRIP to sites of alkylation damage, demonstrating that MMR complexes can function as sensors in DNA damage signal transduction. | Authentic |
Despite the background marrow activity, an osseous metastatic lesion representing recurrent metastatic prostate carcinoma was identified. | Authentic |
Cancer patients undergoing radiotherapy, chemotherapy, or targeted cancer therapy are exposed to the risk of several side effects because of the heavy production of ROS by ionizing radiation or some chemotherapy drugs. | Authentic |
The activation of the phosphatidylinositol-3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) pathways as well as expression of hypoxia-inducible factor 1α (HIF-1α) was determined with or without addition of PI3K or mTOR inhibitor. | Counterfeit |
Mental Health Continuum-Short Form (MHC-SF, adult version) was used to assess the psychological status. | Counterfeit |
miR‑198 is frequently abnormally expressed in various types of human cancers. | Counterfeit |
Immunocytochemistry on three primary cultures of RCC tumor cells and immunohistochemistry on five frozen sections of RCC were performed by utilizing a monoclonal antibody (M-57) to human IL-4R. | Authentic |
We hope that this convenient, rapid, and sensitive platform may become a powerful tool in the field of exosome analysis and early cancer screening. | Authentic |
However, in the absence of these features, uncertainties remain to identify the secondary nature of some cases otherwise defined as de novo AML. | Authentic |
Among the significant factors, the percentage change in FT4 was the only independent factor for 12-month shrinkage (OR = 1.018, 95%CI =1.003-1.032, p = 0.017).Conclusions: Percentage change in serum FT4 on post-treatment Day-4 was an independent blood parameter for the subsequent nodule shrinkage at 12 months. | Authentic |
Acquired factor X deficiency is an uncommon condition, and affected individuals have severe and spontaneous bleeding. | Authentic |
Efficacy (development of disease/therapy-induced signs and symptoms; quality of life) and safety (number and severity of adverse events) of complementary treatment in breast cancer patients treated with sME in the aftercare period were determined. | Authentic |
Twelve MCs (67%) were predominantly hypointense, and 6 MCs (33%) were seen as mixed signal intensity lesions. | Authentic |
Malat1 bound to miR-217 and Sirt1 was a direct target of miR-217. | Counterfeit |
Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. | Counterfeit |
Thus, PGCC formation might represent a fundamental cellular response to Aurora kinase inhibitors and contributes to therapy resistance or tumor relapse. | Authentic |
Median time to progression was 13.6 months (95% CI, 8.9, >16 months), and 26 of 44 patients (59.1%) had progressed. | Authentic |
Overexpressed normal cellular Src, c-Src, and a temperature-sensitive mutant of v-Src also are associated with these perinuclear vesicles. | Authentic |
These observations might reflect adverse biology and/or errors in administrative data. | Authentic |
DIR and CE-T1WI showed similar tumor detection efficacy, and DIR could complement dynamic MRI for detecting breast cancer without a contrast agent. | Authentic |
When AYAs come to accept their illness and gain familiarity with the environment, they then put forth an effort to connect with HCPs. | Authentic |
Importantly, both 1 and 2 inhibited the methicillin-resistant strain Staphylococcus aureus Mu50, with the MIC value of 0.025 μg ml-1. | Counterfeit |
Survival curves constructed using the Kaplan-Meier method were compared using log rank testing. | Authentic |
DJ-1 could be particularly important in cases with discrepancies between the morphologic criteria and clinical parameters. | Authentic |
The incidence rate for the combined years 1999 through 2003 was 30% higher than the rate among U.S. whites (USWs) for the same period. | Authentic |
We retrospectively reviewed the medical records and pathological examinations of patients with completely resected N0 pulmonary adenocarcinoma treated in our institute between 2009 and 2016. | Authentic |
Other objectively measured outcomes include fitness and physical function. | Authentic |
There was no statistical difference regarding gender, median age, blood group, location and staging of tumours, long and hard alcohol and cigarettes consumption, between group A and B. | Authentic |
The intermediate prognosis group (78% of patients surviving eight years) consisted of men with nonulcerated melanomas that were 1.5 mm thick or less. | Authentic |
The authors propose that, in these select diagnostically challenging cases, tissue analyses by CGH may be beneficial before proceeding to more invasive procedures such as sentinel node biopsy and complete lymphadenectomy. | Authentic |
Postoperative axillary lymphoscintigraphic findings should be evaluated in connection with the peroperative axillary lymph node status as established according to the histological analysis, and should take into account the number of removed lymph nodes. | Authentic |
We observed that this combination of epigenetic agents exhibited a synergistic activation of hundreds of genes. | Authentic |
Here, a 34-year-old male presented with a thoracic spinal dumbbell metastatic neuroendocrine carcinoma of unknown primary origin. | Authentic |
These findings suggest that the mechanisms driving ADM differ according to the specific tissue microenvironment and that cancer-associated ADM and acinar atrophy contribute to tumor cell invasion of the local pancreatic parenchyma. | Authentic |
A secondary metastatic cohort was generated and a multivariable Cox proportional hazards model was created to identify factors associated with improved survival. | Authentic |
This treatment strategy has the advantage of sparing patients the late neurologic complications from brain irradiation. | Authentic |
Moreover, the upregulation of IGF‑1R effectively rescued the tumor suppressive roles induced by miR‑379 overexpression in NSCLC. | Counterfeit |
We measured the expression of miR-567 in 37 paired normal and stomach tumour specimens, as well as GC cell lines by Real-time PCR. | Counterfeit |
KYA1797K (1) binds to axin to stabilize the β-catenin destruction complex that causes the phosphorylation and subsequent degradation of Ras, similar to canonical β-catenin regulation. | Authentic |
In this study, circ_0017247 expression was significantly higher in melanoma tissues compared with that in the skin tissues with a melanocytic nevus. | Counterfeit |
In addition, they serve multiple roles in tumor development by participating in physiological processes such as protein metabolism, cell cycle regulation, DNA damage repair and gene transcription. | Authentic |
Among respondents who took actions, most said that the conversation(s) had positively impacted the action. | Authentic |
Histology revealed a moderately well-circumscribed proliferation of well-differentiated squamous cells arranged in trabeculae and nests. | Authentic |
These regulators may probably play an important role in non specific resistance to infections. | Authentic |
Clinical trials are needed to assess the efficacy of IDO inhibition relative to IDO expression, as well as its possible role in combination with anti-PD-1/PD-L1 immunotherapy. | Authentic |
The von Hippel-Lindau tumor suppressor protein (pVHL) is a substrate receptor for the mammalian SCF-2 E3 ubiquitin ligase complex that targets several substrates for ubiquitination and proteasomal degradation. | Authentic |
Pertussis vaccine seems to have no significant influence on tumour development. | Authentic |
We immunohistochemically determined the level of PD-L1 expression using the Tumour Proportion Score system in surgical resections of 133 patients with pulmonary SqCC. | Authentic |
We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). | Authentic |
Suppression of miR-138 obviously reversed the TPL-induced Daoy cell proliferation, migration inhibition, and cell apoptosis enhancement, as well as the inactivation of the PI3K/AKT and Notch pathways. | Counterfeit |
However, the mechanisms for metastasis remain poorly investigated. | Counterfeit |
Here we evaluated the preventive efficacy of rapamycin on Peutz-Jeghers polyposis. | Authentic |
The overall percentage of positive AO-F result was 49% in the 510 patients, 54.1% for males and 40.6% for females. | Authentic |
MiR-221-3p likely plays a role as a PARP1 inhibitor by directly regulating PARP1 expression, thereby affecting the prognoses of TNBC patients. | Authentic |
Capping with ConA and HLA gave quite different results, both in common ALL and T-ALL. | Authentic |
Due to the complexity of their management, pediatric central nervous system (CNS) tumors are not a priority in low- and middle-income countries (LMICs). | Authentic |
The association between survival following CRC diagnosis and identified risk factors was examined using Cox proportional hazard models. | Authentic |
There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson's disease (PD). | Counterfeit |
CRC patients with methylated p14ARF gene promoter had significantly worse prognosis (p=0.036), whereas those with methylated O6-MGMT had significantly better prognosis through the first 60 months post-treatment (RR 0.36; p=0.023). | Authentic |
Background: Mutations in KRAS are negative predictors of the response to anti-EGFR therapies in the treatment of metastatic colorectal cancer. | Authentic |
Compared with the si-NC group, the si-MMP9 group showed increased Collagen II expression but decreased expression of MMP9, Collagen-X and Collagen I and MMP9 activity. | Counterfeit |
The methylation rate of DACH1 in esophageal cancer tissues was higher than that in paracancerous tissues and normal tissues, and the differences were statistically significant (P < 0.05). | Counterfeit |
The DAC-mediated apoptosis was partly due to hypomethylation and up-regulation of XAF1, which resulted in down-regulation of the anti-apoptotic proteins XIAP, cIAP1 and cIAP2. | Authentic |
This study demonstrates that DF-TS boiling histotripsy (BH) has a noninvasive, efficient, and precise ablation ability for TNBC and potentially enhances immune responses. | Authentic |
There was no difference between the sexes for any of the measurements made. | Authentic |
Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associated with the surface of breast cancer cells, which strongly disputes the therapeutic strategies. | Authentic |
Among the immunochemistry markers, T-bet was statistical significantly different between EBV-positive and -negative cases. | Authentic |
Such a methodology allows the rapid establishment of temporary communications with these survivors, as restoring the complex infrastructure is a time-consuming process. | Counterfeit |
As the tumor progresses, tumor immune tolerance is induced under the action of various factors, such that the tumor suppressor microenvironment is continuously transformed into a tumor-promoting microenvironment, which promotes tumor immune escape. | Authentic |
The lncRNA-miRNA-mRNA (long noncoding RNA-microRNA-messenger RNA) interaction is promising biomarkers for the improving prognosis of OC. | Counterfeit |
Combining radiomics with other testing techniques allows every patient to have a personalized treatment plan that is essential for advanced examination and treatment. | Authentic |
Interleukins as immunomodulators are promising therapeutic agents for cancer therapy. | Authentic |
Pathological response rate: Five patients had pathologic state T0 or Tis. | Authentic |
This study aimed to determine the physiological function of PTPRG-AS1 in EOC. | Counterfeit |
All the cases were negative for CDX2, SATB2, PAX8, TTF-1, and Napsin A, while the positive expression of COX2, Villin, and WT-1 was not constant. | Authentic |
This report provides further evidence of the existence of a second PJS disease locus at 19q13.4 and excludes involvement of eight candidate genes. | Authentic |
Adjusted odds ratios (OR) were estimated for stroke, overall morbidity, and mortality using a multivariable logistic regression model, accomplished in stepwise fashion, for patients receiving NC versus those not receiving NC. | Authentic |
We examined the clinical significance of intracellular localization of BRAFV600E in cutaneous melanoma. | Authentic |
Despite this aggressive therapeutic approach, most postoperative complications were transient or could be treated. | Authentic |
To evaluate characteristics associated with higher rates of acceptance for original manuscripts submitted for publication to the International Journal of Radiation Oncology • Biology • Physics (IJROBP) and describe the fate of rejected manuscripts. | Authentic |
Ki-67 immunostaining of cervical cytology is a predictor of significant cervical pathology with high sensitivity and negative predictive value. | Authentic |
Finally, cell apoptosis was evaluated. | Counterfeit |