{{위키데이터 속성 추적}}
{{enzyme
| Name = 지방상 생성효소
| EC_number = 2.3.1.85
| CAS_number = 9045-77-6
| IUBMB_EC_number = 2/3/1/85
| GO_code = 0004312
| image =
| width = 
| caption =
}}
{{#invoke:Infobox_gene|getTemplateData|QID=Q419864}}

'''지방산 생성효소'''({{llang|en|fatty acid synthase}}, '''FAS''')<ref name=":0">{{저널 인용|last1=Paiva |first1=Pedro |last2=Medina |first2=Fabiola E. |last3=Viegas |first3=Matilde |last4=Ferreira |first4=Pedro |last5=Neves |first5=Rui P. P. |last6=Sousa |first6=João P. M. |last7=Ramos |first7=Maria J. |last8=Fernandes |first8=Pedro A. |date=2021-08-11 |title=Animal Fatty Acid Synthase: A Chemical Nanofactory |url=https://pubs.acs.org/doi/10.1021/acs.chemrev.1c00147 |journal=Chemical Reviews |language=en |volume=121 |issue=15 |pages=9502–9553 |doi=10.1021/acs.chemrev.1c00147 |pmid=34156235 |s2cid=235595027 |issn=0009-2665}}</ref> ({{EC number|2.3.1.85}})는 사람에서 FASN [[유전자]]에 의해 암호화되는 [[효소]]이다.<ref name="pmid7835891">{{저널 인용| vauthors = Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ | title = Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene | journal = Genomics | volume = 23 | issue = 2 | pages = 420–424 | date = February 1995 | pmid = 7835891 | doi = 10.1006/geno.1994.1518 }}</ref><ref name="pmid7567999">{{저널 인용| vauthors = Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ | title = Human fatty acid synthase: properties and molecular cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 19 | pages = 8695–8699 | date = Oct 1995 | pmid = 7567999 | pmc = 41033 | doi = 10.1073/pnas.92.19.8695 | bibcode = 1995PNAS...92.8695J | doi-access = free }}</ref><ref name="pmid19027726">{{저널 인용| vauthors = Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U | title = The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative | journal = Chemico-Biological Interactions | volume = 178 | issue = 1–3 | pages = 94–98 | date = Feb 2009 | pmid = 19027726 | pmc = 2896744 | doi = 10.1016/j.cbi.2008.10.040 }}</ref><ref name="entrez">{{웹 인용| title = Entrez Gene: FASN fatty acid synthase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2194}}</ref>

지방산 생성효소는 [[지방산 합성]]을 촉매하는 다중효소 [[단백질]]이다. 지방산 생성효소는 단일 [[효소]]가 아니라 두 개의 동일한 272 kDa의 다중기능 [[폴리펩타이드]]로 구성된 효소 시스템이며, 여기에서 [[기질 (화학)|기질]]은 하나의 기능 도메인에서 다음 기능 도메인으로 전달된다.<ref name=":0" /><ref name="pmid1060077">{{저널 인용| vauthors = Alberts AW, Strauss AW, Hennessy S, Vagelos PR | title = Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 72 | issue = 10 | pages = 3956–3960 | date = October 1975 | pmid = 1060077 | pmc = 433116 | doi = 10.1073/pnas.72.10.3956 | bibcode = 1975PNAS...72.3956A | doi-access = free }}</ref><ref name="pmid1098047">{{저널 인용| vauthors = Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ | title = Presence of two polypeptide chains comprising fatty acid synthetase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 72 | issue = 5 | pages = 1940–1944 | date = May 1975 | pmid = 1098047 | pmc = 432664 | doi = 10.1073/pnas.72.5.1940 | bibcode = 1975PNAS...72.1940S | doi-access = free }}</ref><ref name="pmid1063400">{{저널 인용| vauthors = Smith S, Agradi E, Libertini L, Dileepan KN | title = Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 73 | issue = 4 | pages = 1184–1188 | date = April 1976 | pmid = 1063400 | pmc = 430225 | doi = 10.1073/pnas.73.4.1184 | bibcode = 1976PNAS...73.1184S | doi-access = free }}</ref><ref name="pmid12689621">{{저널 인용| vauthors = Smith S, Witkowski A, Joshi AK | title = Structural and functional organization of the animal fatty acid synthase | journal = Progress in Lipid Research | volume = 42 | issue = 4 | pages = 289–317 | date = July 2003 | pmid = 12689621 | doi = 10.1016/S0163-7827(02)00067-X }}</ref>

지방산 생성효소의 주된 기능은 [[NADPH]]의 존재 하에서 [[아세틸-CoA]] 및 [[말로닐-CoA]]로부터 [[팔미트산]](C16:0, 긴 사슬 [[포화 지방산]])의 합성을 촉매하는 것이다.<ref name="entrez"/>

== 같이 보기 ==
* [[위장관 라이페이스 저해제의 발견 및 개발]]
* [[지방산 합성]]
* [[지방산 대사]]
* [[지방산 분해]]
* [[엔오일-아실기 운반 단백질 환원효소]]
* [[선천성 지질 대사 이상]]

== 각주 ==
{{각주}}

{{효소}}
{{다효소 복합체}}
{{아실기전이효소}}

[[분류:인간 17번 염색체상 유전자]]
[[분류:전달 효소]]
[[분류:EC 2.3.1]]
[[분류:물질대사]]
[[분류:지방산]]
[[분류:NADPH 의존 효소]]
[[분류:구조가 알려진 효소]]