{{위키데이터 속성 추적}}
{{Infobox drug
| drug_name = 
| type = 
| IUPAC_name = (1''R'',3''S'',5''R'',6''R'',9''R'', 11''R'',15''S'',16''R'',17''R'',18''S'',19''E'',21''E'', 23''E'',25''E'',27''E'',29''E'',31''E'',33''R'',35''S'',36''R'',37''S'')- 33-[(3-amino- 3,6-dideoxy- β-<small>D</small>-mannopyranosyl)oxy]- 1,3,5,6,9,11,17,37-octahydroxy- 15,16,18-trimethyl- 13-oxo- 14,39-dioxabicyclo [33.3.1] nonatriaconta- 19,21,23,25,27,29,31-heptaene- 36-carboxylic acid
| image = Amphotericin B new.svg
| alt = 
| caption = 
| image2 =Amphotericin_b.png

<!--Clinical data-->
| tradename = Fungizone, Mysteclin-F, others
| Drugs.com = {{drugs.com|monograph|amphotericin_b}}
| MedlinePlus = 
| licence_EU = 
| licence_US = 
| pregnancy_AU = 
| pregnancy_US = B
| pregnancy_category =  
| legal_status = Rx-only, hospitalization recommended
| routes_of_administration = usually I.V. (slow infusion only)

<!--Pharmacokinetic data-->
| bioavailability = 100% (IV)
| metabolism = kidney
| elimination_half-life = initial phase : 24 hours, <br/> second phase : approx. 15 days
| excretion = 40% found in urine after single cumulated over several days <br/> biliar excretion also important

<!--Identifiers-->
| CAS_number = 1397-89-3
| CAS_number_Ref = {{cascite|correct|??}}
| ATC_prefix = A01
| ATC_suffix = AB04
| ATC_supplemental =  {{ATC|A07|AA07}}, {{ATC|G01|AA03}}, {{ATC|J02|AA01}}
| PubChem = 14956
| DrugBank = DB00681
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
 | ChemSpiderID = 10237579
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| KEGG = D00203
| KEGG_Ref = {{keggcite|correct|kegg}}
| ChEBI = 2682
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 267345
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| NIAID_ChemDB = 000096

<!--Chemical data-->
 | C=47 
| H=73 
| N=1 
| O=17
| molecular_weight = 924.091
| StdInChI = 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
| StdInChIKey = APKFDSVGJQXUKY-INPOYWNPSA-N
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| melting_point = 170
| verifiedrevid = 477002307
| Watchedfields = changed
| smiles = O=C(O)[C@@H]3[C@@H](O)C[C@@]2(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)C=CC=CC=CC=CC=CC=CC=C[C@H](O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O)C[C@@H]3O2
}}
'''암포테리신 B'''({{lang|en|Amphotericin B}})는 심각한 [[진균증]], [[리슈만편모충증]]에 대한 [[항진균제]]이다.<ref name=WHO2010>{{서적 인용|title=Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases|date=March 2010|publisher=World Health Organization|isbn=9789241209496|pages=55, 88, 186|url=http://apps.who.int/iris/bitstream/10665/44412/1/WHO_TRS_949_eng.pdf}}</ref> 이 항진균제는 [[아스페르길루스증]], [[분아균증]], [[칸디다증]], [[콕시디오이데스진균증]], [[크립토콕쿠스증]]을 치료하는데 사용된다.<ref name=AHFS2015/>
특정 감염의 경우 [[플루시토신]]과 함께 처방된다.<ref name=WHO2008>{{서적 인용|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=9789241547659|page=145|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate= 8 December 2016}}</ref> 일반적으로 [[수액 (의학)|수액]]을 통해 복용된다.<ref name=AHFS2015>{{웹 인용|title = Amphotericin B|url = http://www.drugs.com/monograph/amphotericin-b.html|publisher = The American Society of Health-System Pharmacists|accessdate = Jan 1, 2015}}</ref>

암포테리신 B는 본래 1955년 [[방선균]](Streptomyces nodosus)으로부터 만들어졌다.<ref name=Wal2012>{{서적 인용|last1=Walker|first1=S. R.|title=Trends and Changes in Drug Research and Development|date=2012|publisher=Springer Science & Business Media|isbn=9789400926592|page=109|url=https://books.google.ca/books?id=FB_2CAAAQBAJ&pg=PA109|language=en}}</ref> [[의료제도]]에 필수적인, 가장 효과적이고 안전한 의약품을 가리키는 [[세계 보건 기구 필수 의약품]]으로 지정되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015}}</ref> [[제네릭 의약품]]으로 이용 가능하다.<ref name=AHFS2015/>

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{언어링크|en}} [http://www.medicines.org.uk/emc/medicine/1236 AmBisome Summaries of Product Characteristics (United Kingdom)]

{{토막글|의학}}

[[분류:항진균제]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:항원충제]]
[[분류:폴리엔]]
[[분류:길리어드 사이언스]]
[[분류:알돌]]
[[분류:콩팥 독소]]