{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 458266592
| IUPAC_name = 4-''O''-β-<small>D</small>-Galactopyranosyl-β-<small>D</small>-fructofuranose<br />OR<br />(2''S'',3''R'',4''S'',5''R'',6''R'')-2-((2''R'',3''S'',4''S'',5''R'')-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yloxy)-6-(hydroxymethyl)tetrahydro-2''H''-pyran-3,4,5-triol
| image = Lactulose structure.svg
| width = 225
| image2 = Haworth projection of lactulose.svg
| width2 = 225
| caption = Haworth projection of lactulose (bottom)

<!--Clinical data-->
| pronounce = {{IPAc-en|ˈ|l|æ|k|tj|ʊ|l|oʊ|z}}
| tradename = Cholac, Generlac, Consulose, Duphalac, others
| Drugs.com = {{drugs.com|monograph|lactulose}}
| MedlinePlus = a682338
| pregnancy_US = B
| legal_UK = P
| legal_US = Rx-only
| routes_of_administration = [[:en:Oral administration|By mouth]] (oral solution)

<!--Pharmacokinetic data-->
| bioavailability = Poorly absorbed
| metabolism = 100% in colon by [[:en:enteric]] bacteria
| onset = 8 to 48 hours<ref name=Gold2006/><ref name=Helm2006/>
| elimination_half-life = 1.7-2 hours
| excretion = Fecal

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 4618-18-2
| ATC_prefix = A06
| ATC_suffix = AD11
| PubChem = 11333
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00581
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10856
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 9U7D5QH5AE
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00352
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6359
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 296306

<!--Chemical data-->
| C=12 | H=22 | O=11
| molecular_weight = 342.296 g/mol
| smiles = O[C@H]2[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O[C@]2(O)CO)CO
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JCQLYHFGKNRPGE-FCVZTGTOSA-N
}}

'''락툴로오즈'''(Lactulose)는 [[변비]]와 [[간성뇌증]] 치료에 사용되는 흡수가 되지 않는 [[설탕]]이다.<ref name=AHFS2015/><ref name=Ham2013/> 변비의 경우 구강을 통해 복용되며, 간성뇌증의 경우 구강이나 직장을 통해 투여된다.<ref name=AHFS2015>{{웹 인용|title=Lactulose
|url=http://www.drugs.com/monograph/lactulose.html|publisher=The American Society of Health-System Pharmacists|accessdate=Aug 11, 2015}}</ref> 보통 8~12시간 후에 효력이 시작되지만 변비 개선에 최대 이틀이 소요될 수도 있다.<ref name=Gold2006>{{서적 인용|last1=Goldman|first1=edited by Ann|last2=Hain|first2=Richard|last3=Liben|first3=Stephen|title=Oxford textbook of palliative care for children|date=2006|publisher=Oxford University Press|location=Oxford|isbn=9780198526537|page=352|edition=2|url=https://books.google.ca/books?id=f1fTsoA4wDMC&pg=PA352}}</ref><ref name=Helm2006>{{서적 인용|last1=Helms|first1=Richard A.|title=Textbook of therapeutics : drug and disease management|date=2006|publisher=Lippincott Williams & Wilkins|location=Philadelphia, Pa. [u.a.]|isbn=9780781757348|page=1310|edition=8|url=https://books.google.ca/books?id=aVmRWrknaWgC&pg=PA1310}}</ref>

락툴로오즈는 1929년에 처음 제조되었고 1950년대에 의학적으로 사용되기 시작했다.<ref>{{서적 인용|last1=McSweeney|first1=P.L.H.|last2=Fox|first2=P.F.|title=Advanced dairy chemistry.|date=2009|publisher=Springer-Verlag|location=New York|isbn=9780387848655|page=236|edition=3rd|url=https://books.google.ca/books?id=hz9U9nzy-rQC&pg=PA236}}</ref><ref>{{저널 인용|last1=Schumann|first1=C|title=Medical, nutritional and technological properties of lactulose. An update.|journal=European journal of nutrition|date=November 2002|volume=41 Suppl 1|pages=I17-25|pmid=12420112|doi=10.1007/s00394-002-1103-6}}</ref> 
[[의료제도]]에 필수적인, 가장 효과적이고 안전한 약물이 기재된 [[WHO 필수 약물 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015}}</ref> [[일반의약품]]으로 구매가 가능하다.<ref name=Ham2013>{{서적 인용|last1=Hamilton|first1=Richard J.|title=Tarascon pocket pharmacopoeia : 2013 classic shirt-pocket edition|date=2013|publisher=Jones & Bartlett Learning|location=Burlington, Ma.|isbn=9781449665869|page=111|edition=27|url=https://books.google.ca/books?id=lwueJ4IAl4oC&pg=PA111}}</ref>

== 각주 ==
{{각주}}

{{탄수화물}}
{{전거 통제}}
{{토막글|의학}}

[[분류:탄수화물]]
[[분류:이당류]]
[[분류:위장병학]]
[[분류:완하제]]
[[분류:세계 보건 기구 필수 의약품]]