{{위키데이터 속성 추적}}
'''하이드록시카복실산 수용체 3'''({{llang|en|hydroxycarboxylic acid receptor 3}}, '''HCA<sub>3</sub>''')는 사람에서 HCAR3 [[유전자]]에 의해 암호화되는 [[단백질]]이다.<ref name="entrez">{{웹 인용| title = Entrez Gene: GPR109B G protein-coupled receptor 109B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8843}}</ref><ref name="pmid7505609">{{저널 인용| vauthors = Nomura H, Nielsen BW, Matsushima K | title = Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors | journal = International Immunology | volume = 5 | issue = 10 | pages = 1239–49 | date = October 1993 | pmid = 7505609 | doi = 10.1093/intimm/5.10.1239 }}</ref> '''니아신 수용체 2'''({{llang|en|niacin receptor 2}}, '''NIACR2'''), '''G 단백질 연결 수용체 109B'''({{llang|en|G protein-coupled receptor 109B}}, '''GPR109B''')라고도 한다.<ref>{{저널 인용|title=International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)|journal=Pharmacological Reviews|date=June 2011|volume=63|issue=2|pages=269–90|doi=10.1124/pr.110.003301|pmid=21454438|vauthors=Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP|doi-access=free}}</ref> 하이드록시카복실산 수용체 3(HCA<sub>3</sub>)은 다른 [[하이드록시카복실산 수용체]]인 [[하이드록시카복실산 수용체 1]](HCA<sub>1</sub>) 및 [[하이드록시카복실산 수용체 2]](HCA<sub>2</sub>)와 마찬가지로 [[Gi 단백질 α 소단위체|G<sub>i/o</sub>-연결]] [[G 단백질 연결 수용체]](GPCR)이다.<ref name="IUPHAR's comprehensive 2011 review on HCARs" /><ref name="IUPHAR-DB HCAR family page" /> 하이드록시카복실산 수용체 3(HCA<sub>3</sub>)의 주요 [[내인성]] [[작용제]]는 [[3-하이드록시옥탄산]] 및 [[키뉴렌산]]이다.<ref name="IUPHAR's comprehensive 2011 review on HCARs">{{저널 인용| vauthors = Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP | title = International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B) | journal = Pharmacological Reviews | volume = 63 | issue = 2 | pages = 269–90 | date = June 2011 | pmid = 21454438 | doi = 10.1124/pr.110.003301 | doi-access = free }}</ref><ref name="IUPHAR-DB HCAR family page">{{웹 인용|author1=S Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters |title=Hydroxycarboxylic acid receptors |url=http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=48 |website=IUPHAR/BPS Guide to Pharmacology |publisher=International Union of Basic and Clinical Pharmacology |access-date=13 July 2018}}</ref><ref>{{저널 인용|last1=Kapolka |first1=NJ |last2=Taghon |first2=GJ |last3=Rowe |first3=JB |last4=Morgan |first4=WM |last5=Enten |first5=JF |last6=Lambert |first6=NA |last7=Isom |first7=DG |title=DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery. |journal=Proceedings of the National Academy of Sciences of the United States of America |date=9 June 2020 |volume=117 |issue=23 |pages=13117–13126 |doi=10.1073/pnas.2000430117 |pmid=32434907|pmc=7293659 |bibcode=2020PNAS..11713117K |doi-access=free }}</ref> 하이드록시카복실산 수용체 3(HCA<sub>3</sub>)는 또한 [[니아신]](일명 [[니코틴산]])에 대한 [[리간드 (생화학)|저친화성]] [[생체분자 표적]]이다.<ref>{{저널 인용|last1=Peters |first1=A |last2=Krumbholz |first2=P |last3=Jäger |first3=E |last4=Heintz-Buschart |first4=A |last5=Çakir |first5=MV |last6=Rothemund |first6=S |last7=Gaudl |first7=A |last8=Ceglarek |first8=U |last9=Schöneberg |first9=T |last10=Stäubert |first10=C |title=Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3. |journal=PLOS Genetics |date=May 2019 |volume=15 |issue=5 |pages=e1008145 |doi=10.1371/journal.pgen.1008145 |pmid=31120900|pmc=6532841 |doi-access=free }}</ref>

== 같이 보기 ==
* [[하이드록시카복실산]]
* [[하이드록시카복실산 수용체]]
* [[하이드록시카복실산 수용체 1]]
* [[하이드록시카복실산 수용체 2]]

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{웹 인용 | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3009 | title = Nicotinic Acid Receptor Family: GPR109B | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | 확인날짜 = 2023-08-11 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303180138/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3009 | url-status =  }}

== 더 읽을거리 ==
{{참고 자료 시작|33em}}
* {{저널 인용| vauthors = Nomura H, Nielsen BW, Matsushima K | title = Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors | journal = International Immunology | volume = 5 | issue = 10 | pages = 1239–49 | date = October 1993 | pmid = 7505609 | doi = 10.1093/intimm/5.10.1239 }}
* {{저널 인용| vauthors = Zingoni A, Rocchi M, Storlazzi CT, Bernardini G, Santoni A, Napolitano M | title = Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor | journal = Genomics | volume = 42 | issue = 3 | pages = 519–23 | date = June 1997 | pmid = 9205127 | doi = 10.1006/geno.1997.4754 | hdl = 11573/245592 }}
* {{저널 인용| vauthors = Irobi J, Nelis E, Verhoeven K, De Vriendt E, Dierick I, De Jonghe P, Van Broeckhoven C, Timmerman V | title = Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3 | journal = Journal of the Peripheral Nervous System | volume = 7 | issue = 2 | pages = 87–95 | date = June 2002 | pmid = 12090300 | doi = 10.1046/j.1529-8027.2002.02014.x | s2cid = 8453412 }}
* {{저널 인용| vauthors = Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB | title = Molecular identification of high and low affinity receptors for nicotinic acid | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9869–74 | date = March 2003 | pmid = 12522134 | doi = 10.1074/jbc.M210695200 | doi-access = free }}
* {{저널 인용| vauthors = Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S | s2cid = 20451806 | title = PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect | journal = Nature Medicine | volume = 9 | issue = 3 | pages = 352–5 | date = March 2003 | pmid = 12563315 | doi = 10.1038/nm824 }}
* {{저널 인용| vauthors = Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, Hiyama H, Matsuo A, Matsushime H, Furuichi K | title = Molecular identification of nicotinic acid receptor | journal = Biochemical and Biophysical Research Communications | volume = 303 | issue = 1 | pages = 364–9 | date = March 2003 | pmid = 12646212 | doi = 10.1016/S0006-291X(03)00342-5 }}
* {{저널 인용| vauthors = Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, de Daruvar A, Wincker P, Serre G, Guerrin M | title = Large-scale identification of human genes implicated in epidermal barrier function | journal = Genome Biology | volume = 8 | issue = 6 | pages = R107 | year = 2007 | pmid = 17562024 | pmc = 2394760 | doi = 10.1186/gb-2007-8-6-r107 }}
{{참고 자료 끝}}

[[분류:인간 12번 염색체상 유전자]]
[[분류:G 단백질 연결 수용체]]