{{위키데이터 속성 추적}}
{{drugbox
|Verifiedfields = changed
|Watchedfields = changed
|verifiedrevid = 464387972
|IUPAC_name = (-)-(''S'')-3-Hydroxy-2-phenylpropionic acid (1''R'',2''R'',4''S'',7''S'',9''S'')-9-methyl-3-oxa-9-azatricyclo[3.3.1.0<sup>2,4</sup>]non-7-yl ester
|image = L-Scopolamin.svg
|width = 200
|image2 = Scopolamine structure.png

<!--Clinical data-->
|tradename = Transdermscop, Kwells, others
|synonyms = hyoscine hydrobromide, scopolamine hydrobromide
|Drugs.com = {{drugs.com|monograph|scopolamine}}
|pregnancy_AU = B2
|pregnancy_US = C
|legal_AU = S2
|legal_CA = Rx-only
|legal_UK = POM
|legal_US = Rx-only
|routes_of_administration = by mouth, skin patch, eye drops, subcutaneous, intravenous, sublingual, rectal, buccal transmucousal, intramuscular
<!--Pharmacokinetic data-->
|bioavailability = 
|protein_bound = 
|metabolism = [[간]]
|excretion = [[콩팥]]
|elimination_half-life = 4.5 hours<ref name="pmid2762223">{{저널 인용|author1=Putcha, L. |author2=Cintron, N. M. |author3=Tsui, J. |author4=Vanderploeg, J. M. |author5=Kramer, W. G. |title = Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects |journal = Pharmacology Research |volume = 6 |issue = 6 |pages = 481-485 |year = 1989 |pmid = 2762223 |doi = 10.1023/A:1015916423156 |url =}}</ref>
<!--Identifiers-->
|CAS_number_Ref = {{cascite|correct|??}}
|CAS_number = 51-34-3
|ATC_prefix = A04
|ATC_suffix = AD01
|ATC_supplemental = {{ATC|N05|CM05}}, {{ATC|S01|FA02}}
|ChEBI_Ref = {{ebicite|correct|EBI}}
|ChEBI = 16794
|PubChem = 5184
|IUPHAR_ligand = 330
|DrugBank_Ref = {{drugbankcite|correct|drugbank}}
|DrugBank = DB00747
|ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|ChemSpiderID = 10194106
|UNII_Ref = {{fdacite|correct|FDA}}
|UNII = DL48G20X8X
|KEGG_Ref = {{keggcite|correct|kegg}}
|KEGG = D00138
|ChEMBL_Ref = {{ebicite|changed|EBI}}
|ChEMBL = 1201024
<!-- Chemical data -->
|C=17 |H=21 |N=1 |O=4
|molecular_weight = 303.353 g/mol
|smiles = OC[C@H](c1ccccc1)C(=O)O[C@@H]2C[C@H]3N(C)[C@@H](C2)[C@@H]4O[C@H]34
|StdInChI_Ref = {{stdinchicite|correct|chemspider}}
|StdInChI = 1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1
|StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|StdInChIKey = STECJAGHUSJQJN-FWXGHANASA-N
}}
'''히오스신'''({{lang|en|Hyoscine}}), '''스코폴라민'''({{lang|en|scopolamine}})<ref name=Huo2001>{{서적 인용|last1=Juo|first1=Pei-Show|title=Concise Dictionary of Biomedicine and Molecular Biology.|date=2001|publisher=CRC Press|location=Hoboken|isbn=9781420041309|page=570|edition=2nd|url=https://books.google.ca/books?id=Y4DLBQAAQBAJ&pg=PA570}}</ref>은 [[멀미]]와 구토 치료에 사용되는 약물이다. 수술 전에 [[침]]을 줄이기 위해 사용되기도 한다. 주사할 경우 약 20분 뒤에 효력이 시작되어 최대 8시간까지 지속된다. 구강이나 [[스킨 패치]]로 사용할 수도 있다.<ref name=AHFS2016>{{웹 인용|title=Scopolamine
|url=https://www.drugs.com/monograph/scopolamine.html|publisher=The American Society of Health-System Pharmacists|accessdate= 8 December 2016}}</ref>

히오스신은 1881년 즈음에 처음 문서화되어 1947년에 의학적인 이용이 시작되었다.<ref name=Fis2006>{{서적 인용|last1=Fischer|first1=Janos|last2=Ganellin|first2=C. Robin|title=Analogue-based Drug Discovery|date=2006|publisher=John Wiley & Sons|isbn=9783527607495|page=551|url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA551|language=en}}</ref> [[의료제도]]에 필수적인, 가장 효과적이고 안전한 약물이 나열된 [[WHO 필수 약물 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015}}</ref> 히오스신은 [[가지과]] 식물에서 추출하여 만든다.<ref>{{서적 인용|last1=Osbourn|first1=Anne E.|last2=Lanzotti|first2=Virginia|title=Plant-derived Natural Products: Synthesis, Function, and Application|date=2009|publisher=Springer Science & Business Media|isbn=9780387854984|page=5|url=https://books.google.ca/books?id=Y8SpVXEng4QC&pg=PA6|language=en}}</ref>

== 식물에서의 합성 ==
[[파일:Scopolamine biosynthesis.svg|가운데|800px]]

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{위키공용분류-줄}}

{{전거 통제}}

[[분류:에폭사이드]]
[[분류:무스카린 대항제]]
[[분류:식물 독소]]
[[분류:프로피오네이트]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:의식용 환각제]]
[[분류:트로페인 알칼로이드]]