{{위키데이터 속성 추적}}
{{drugbox
| Watchedfields = changed
| drug_name =
| verifiedrevid = 459476549
| IUPAC_name = 4-[(3''S'',5''R'',8''R'',9''S'',10''S'',12''R'',13''S'',14''S'')-3-[(2''S'',4''S'',5''R'',6''R'')-5-[(2''S'',4''S'',5''R'',6''R'')-5-[(2''S'',4''S'',5''R'',6''R'')-4,5-dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[''a'']phenanthren-17-yl]-5''H''-furan-2-one
| image = Digoxin.svg
| width = 300px
| image2 = Digon ball-and-stick.png
<!--Clinical data-->
| pronounce = {{IPAc-en|d|ᵻ|ˈ|dʒ|ɒ|k|s|ᵻ|n}}, with a soft gee<ref>OED</ref>
| tradename = Lanoxin, others
| Drugs.com = {{drugs.com|monograph|digoxin}}
| MedlinePlus = a682301
| pregnancy_US = C
| pregnancy_AU = A
| pregnancy_category =
| legal_AU = S4
| legal_UK = POM
| legal_US = ℞-only
| legal_status =
| routes_of_administration = [[:en:Route of administration#Enteral|by mouth]], [[수액 (의학)|intravenous]]
<!--Pharmacokinetic data-->
| bioavailability = 60 to 80% (by mouth)
| protein_bound = 25%
| metabolism = [[간]] (16%)
| elimination_half-life = 36 to 48 [[시 (단위)]]s <br /><small>(normal [[신장의 오줌 생성 및 조절]])</small><br />3.5 to 5 [[날]]s <br /><small>(impaired kidney function)</small>
| excretion = [[콩팥]]
<!--Identifiers-->
| IUPHAR_ligand = 4726
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 20830-75-5
| ATC_prefix = C01
| ATC_suffix = AA05
| ATC_supplemental =
| StdInChI = 1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
| PubChem = 2724385
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00390
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2006532
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 73K4184T59
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00298
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 4551
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1751
<!--Chemical data-->
| C=41 | H=64 | O=14
| SMILES = O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = LTMHDMANZUZIPE-PUGKRICDSA-N
| melting_point = 249.3
| solubility = 0.0648
}}

'''디곡신'''({{lang|en|digoxin}}, 브랜드명: '''Lanoxin''' 등)은 다양한 [[심혈관계 질환]]을 치료하기 위해 사용되는 약물이다.<ref name=AHFS2016/> 대부분은 [[심방세동]], [[심방조동]], [[심부전]]을 대상으로 사용된다.<ref name=AHFS2016/> 디곡신은 구강이나 [[수액 (의학)|정맥 주사]]를 통해 투여한다.<ref name=AHFS2016>{{웹 인용|title=Digoxin|url=https://www.drugs.com/monograph/digoxin.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221004328/https://www.drugs.com/monograph/digoxin.html|archivedate=21 December 2016|df=}}</ref>

일반적인 부작용으로는 [[여성형유방증|유방확대]]가 포함되며, 그 밖의 다른 부작용들은 대개 과도한 복용으로 인한 것이다.<ref name=AHFS2016/><ref name=WHO2008/> 이 부작용들에는 [[부정맥]], 오심(속쓰림), 구토, 두통, 시야혼탁([[황색증]]) 및 졸음, 식욕 부진이 포함될 수 있다.<ref name=WHO2008/> 노인과 [[신장의 오줌 생성 및 조절|신장 질환]]이 있는 환자에게는 더 많은 주의가 필요하다.<ref name=WHO2008>{{서적 인용|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=9789241547659|page=270|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161213060118/http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|archivedate=13 December 2016|df=}}</ref> [[임신]] 중에 투여해도 안전한지의 여부에 관해 분명하지 않다.<ref>{{웹 인용|title=Digoxin Use During Pregnancy {{!}} Drugs.com|url=https://www.drugs.com/pregnancy/digoxin.html|website=www.drugs.com|accessdate=14 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221004656/https://www.drugs.com/pregnancy/digoxin.html|archivedate=21 December 2016|df=}}</ref> 디곡신은 [[강심 배당체]] 계열의 약물에 속한다.<ref name=AHFS2016/>

디곡신은 1930년 [[디기탈리스]] 식물 [[디기탈리스 라타나]]로부터 최초로 분리되었다.<ref>{{서적 인용|last1=Cartwright|first1=Anthony C.|title=The British Pharmacopoeia, 1864 to 2014: Medicines, International Standards and the State|date=2016|publisher=Routledge|isbn=9781317039792|page=183|url=https://books.google.com/books?id=gI21CwAAQBAJ&pg=PA183|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170908135429/https://books.google.com/books?id=gI21CwAAQBAJ&pg=PA183|archivedate=2017-09-08|df=}}</ref><ref>{{저널 인용|last1=Hollman|first1=A|title=Drugs for atrial fibrillation. Digoxin comes from Digitalis lanata|journal=BMJ (Clinical research ed.)|date=6 April 1996|volume=312|issue=7035|pages=912|pmid=8611904|pmc=2350584|doi=10.1136/bmj.312.7035.912}}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|publisher=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}}</ref> [[개발도상국]]의 도매가는 한 달에 대략 US$0.21–6.60이다.<ref name=ERC2014>{{웹 인용|title=Digoxin|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=266&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=8 December 2016|보존url=https://web.archive.org/web/20181121120236/http://mshpriceguide.org/en/single-drug-information/?DMFId=266&searchYear=2014|보존날짜=2018-11-21|url-status=dead}}</ref> 미국에서는 2015년 기준으로 대체적으로 한 달에 $25 미만의 비용이 든다.<ref name=Ric2015>{{서적 인용|last1=Hamilton|first1=Richart|title=Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition|date=2015|publisher=Jones & Bartlett Learning |isbn=9781284057560|page=X}}</ref> 2016년, 미국에서는 400만 건 이상의 처방과 더불어 145번째로 처방을 많이 받은 약물이었다.<ref>{{웹 인용|title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}}</ref>

== 각주 ==
{{각주}}

== 추가 문헌 ==
* {{서적 인용|vauthors=Rang HP, Dale MM, Ritter JM, Moore PK | title = Pharmacology | publisher = Churchill Livingstone | location = Edinburgh | year = 2003 | isbn = 0-443-07145-4 | pages= | edition = 5th }}
* [[:en:Summary of Product Characteristics]], Digoxin 0,125&nbsp;mg, Zentiva a.s.
* {{서적 인용| author = Lüllmann | title = Pharmakologie und Toxikologie | publisher = Georg Thieme Verlag | location= | year = 2003 | isbn = 3-13-368515-5 | edition = 15th }}
* [[:en:Lanatoside C]] (isolanid, Cedilanid – four glycoside analog), [[:en:Digoxigenin]] (aglycone analog)
* {{저널 인용|vauthors=Goldberger AD, Alexander GC |title=Refitting the Foxglove: Digoxin Use in Contemporary Clinical Practice |journal=JAMA Internal Medicine |doi=10.1001/jamainternmed.2013.10432 |volume=174 |year=2014 |page=151}}

== 외부 링크 ==
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Digoxin U.S. National Library of Medicine: Drug Information Portal — Digoxin]
* [http://clincalc.com/Digoxin Commonly used website to calculate empiric digoxin doses for medical purposes for heart problems]
* [http://www.rcsb.org/pdb/explore.do?structureId=3B0W Protein Data Bank entry] (useful for computational molecular dynamics)

[[분류:카르데놀라이드]]
[[분류:IARC 2B군 발암 물질]]
[[분류:세계 보건 기구 필수 의약품]]