{{위키데이터 속성 추적}}
{{Chembox
<!-- Images -->
| ImageFile1 = Estradiol.svg
| ImageSize1 = 225px
| ImageAlt1 = The chemical structure of estradiol.
| ImageFile2 = Estradiol 3D ball.png
| ImageSize2 = 225px
| ImageAlt2 = A ball-and-stick model of estradiol.
<!-- Names -->
| pronounce = {{IPAc-en|ˌ|ɛ|s|t|r|ə|ˈ|d|aɪ|oʊ|l}} {{respell|ES|trə|DY|ohl}}<ref name="FordRoach2013">{{서적 인용| first1 = Susan M. | last1 = Ford | first2 = Sally S. | last2 = Roach | name-list-style = vanc | title = Roach's Introductory Clinical Pharmacology |url= https://books.google.com/books?id=LwOaAgAAQBAJ&pg=PA525 |date=7 October 2013|publisher=Lippincott Williams & Wilkins|isbn=978-1-4698-3214-2|pages=525–}}</ref><ref name="HochadelMosby2015">{{서적 인용| first1 = Maryanne | last1 = Hochadel | name-list-style = vanc |title=Mosby's Drug Reference for Health Professions|url=https://books.google.com/books?id=IuF1BwAAQBAJ&pg=PA602|date=1 April 2015|publisher=Elsevier Health Sciences|isbn=978-0-323-31103-8|pages=602–}}</ref>
| IUPACName = (8''R'',9''S'',13''S'',14''S'',17''S'')-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthrene-3,17-diol
| OtherNames = Oestradiol; E2; 17β-Estradiol; Estra-1,3,5(10)-triene-3,17β-diol; 17β-Oestradiol
| Watchedfields = changed
| verifiedrevid = 488623959
<!-- Sections -->
| Section1 = {{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 50-28-2
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 16469
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 135
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5554
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00783
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00105
| PubChem = 5757
| SMILES = C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2O)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VOXZDWNPVJITMN-ZBRFXRBCSA-N
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 4TI98Z838E
  }}
| Section2 = {{Chembox Properties
| C=18 | H=24 | O=2
| MolarMass = 272.38 g/mol
| Appearance = 
| Density = 
| MeltingPt = 
| BoilingPt = 
| Solubility = 
| MagSus = -186.6·10<sup>−6</sup> cm<sup>3</sup>/mol
  }}
| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
  }}
| Section6 = {{Chembox Pharmacology
| ATCvet = 
| ATCCode_prefix = G03
| ATCCode_suffix = CA03
| ATC_Supplemental = 
| Licence_EU=yes
| AdminRoutes = [[Oral administration|Oral]], [[sublingual administration|sublingual]], [[intranasal administration|intranasal]], [[topical medication|topical]]/[[transdermal]], [[intravaginal administration|vaginal]], [[intramuscular injection|intramuscular]] or [[subcutaneous injection|subcutaneous]] (as an [[estradiol ester|ester]]), [[subdermal implant]]
| Bioavail = Oral: <5%<ref name="StanczykArcher2013">{{저널 인용| vauthors = Stanczyk FZ, Archer DF, Bhavnani BR | title = Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment | journal = Contraception | volume = 87 | issue = 6 | pages = 706–27 | date = June 2013 | pmid = 23375353 | doi = 10.1016/j.contraception.2012.12.011 }}</ref>
| Excretion = [[Urine]]: 54%<ref name="StanczykArcher2013" /><br />[[Feces]]: 6%<ref name="StanczykArcher2013" />
| HalfLife = Oral: 13–20 hours<ref name="StanczykArcher2013" /><br />Sublingual: 8–18 hours<ref name="PriceBlauer1997">{{저널 인용| vauthors = Price TM, Blauer KL, Hansen M, Stanczyk F, Lobo R, Bates GW | title = Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol | journal = Obstetrics and Gynecology | volume = 89 | issue = 3 | pages = 340–5 | date = March 1997 | pmid = 9052581 | doi = 10.1016/S0029-7844(96)00513-3 | s2cid = 71641652 }}</ref><br />Topical (gel): 36.5 hours<ref name="NauntonAl Hadithy2006">{{저널 인용| vauthors = Naunton M, Al Hadithy AF, Brouwers JR, Archer DF | title = Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women | journal = Menopause | volume = 13 | issue = 3 | pages = 517–27 | year = 2006 | pmid = 16735950 | doi = 10.1097/01.gme.0000191881.52175.8c | s2cid = 42748448 }}</ref>
| Metabolism = [[Liver]] (via [[hydroxylation]], [[sulfation]], [[glucuronidation]])
| ProteinBound = ~98%:<ref name="StanczykArcher2013" /><ref name="FalconeHurd2007">{{서적 인용| first1 = Tommaso | last1 = Falcone | first2 = William W. | last2 = Hurd | name-list-style = vanc | title = Clinical Reproductive Medicine and Surgery|url=https://books.google.com/books?id=fOPtaEIKvcIC&pg=PA22|year=2007|publisher=Elsevier Health Sciences|isbn=978-0-323-03309-1|pages=22–}}</ref><br />• [[Human serum albumin|Albumin]]: 60%<br />• {{abbr|SHBG|sex hormone-binding globulin}}: 38%<br />• Free: 2%
  }}
}}
'''에스트라디올'''({{llang|en|estradiol}}), 정확히 '''17β-에스트라다이올'''({{llang|en|17β-estradiol}})은 [[성 호르몬]]인 [[스테로이드]]이다. 어원은 [[라틴어]] oestrus이다. 여성의 [[발정 주기]]와 [[월경 주기]]에서 중요한 역할을 담당하는 [[호르몬]]이다. 17α-에스트라다이올이라고 불리는 [[알파트라디올]](alfatradiol)과는 다른 호르몬이다.

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{위키공용분류-줄}}

{{호르몬}}
{{스테로이드 호르몬}}

{{전거 통제}}
{{토막글|해부학}}

[[분류:동물생식계]]
[[분류:성호르몬]]
[[분류:산화 방지제]]
[[분류:간독소]]
[[분류:에스트로겐]]
[[분류:에스트란]]
[[분류:GPER 작용제]]
[[분류:시상하부-뇌하수체-프로락틴 축 호르몬]]
[[분류:시상하부-뇌하수체-생식샘 축 호르몬]]