{{위키데이터 속성 추적}}
'''뉴로텐신 수용체 1'''(Neurotensin receptor type 1, NTR1)은 인간에서 ''NTSR1'' [[유전자]]에 의해 암호화 된 [[단백질]]이다.<ref name="pmid8075503">{{저널 인용|제목=Chromosomal localization of mouse and human neurotensin receptor genes|저널=Mammalian Genome|날짜=May 1994|권=5|호=5|쪽=303–6|doi=10.1007/BF00389545|pmc=|pmid=8075503}}</ref><ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923|제목=Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)|확인날짜=}}</ref>

== 기능 ==
NTR1이라고도 하는 뉴로텐신 수용체 1은 [[G단백질]] 결합 수용체의 초 군에 속하며 클래스 A GPCR로 간주된다. NTSR1은 여러 생물학적 변조를 통해 [[저혈압]], 고혈당, [[저체온증]], 장 운동 및 분비를 조절한다.<ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923|제목=Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)|확인날짜=}}</ref>

== 리간드 ==

* ML314-β 어레스틴 편향 작용제<ref name="pmid24611085">{{저널 인용|제목=Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor|저널=ACS Med Chem Lett|url=|연도=2013|권=4|호=9|쪽=846–851|doi=10.1021/ml400176n|pmc=3940307|pmid=24611085}}</ref>
* 뉴로텐신(NT1)

== 같이 보기 ==
* [[뉴로텐신 수용체]]

== 각주 ==
{{각주}}

== 추가 자료 ==
{{참고 자료 시작|2}}
* {{저널 인용|제목=Neurotensin receptors: binding properties, transduction pathways, and structure|저널=Cellular and Molecular Neurobiology|날짜=Oct 1995|권=15|호=5|쪽=501–12|doi=10.1007/BF02071313|pmid=8719037}}
* {{저널 인용|제목=Neurotensin and neurotensin receptors|저널=Trends in Pharmacological Sciences|날짜=Jul 1999|권=20|호=7|쪽=302–9|doi=10.1016/S0165-6147(99)01357-7|pmid=10390649}}
* {{저널 인용|제목=Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor|저널=FEBS Letters|날짜=Feb 1993|권=317|호=1–2|쪽=139–42|doi=10.1016/0014-5793(93)81509-X|pmid=8381365}}
* {{저널 인용|제목=Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene|저널=The Journal of Biological Chemistry|날짜=Jan 1997|권=272|호=2|쪽=1315–22|doi=10.1074/jbc.272.2.1315|pmid=8995438}}
* {{저널 인용|제목=Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra|저널=The Journal of Neuroscience|날짜=Oct 1998|권=18|호=20|쪽=8473–84|doi=10.1523/JNEUROSCI.18-20-08473.1998|pmid=9763490}}
* {{저널 인용|제목=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction|저널=The Journal of Biological Chemistry|날짜=Oct 1999|권=274|호=42|쪽=30202–8|doi=10.1074/jbc.274.42.30202|pmid=10514511}}
* {{저널 인용|제목=Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease|저널=Clinical Cancer Research|날짜=Feb 2000|권=6|호=2|쪽=566–71|doi=|pmid=10690540}}
* {{저널 인용|제목=A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist|저널=Biochemical Pharmacology|날짜=Sep 2000|권=60|호=6|쪽=793–801|doi=10.1016/S0006-2952(00)00409-3|pmid=10930533}}
* {{저널 인용|제목=Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*|저널=The Journal of Biological Chemistry|날짜=Jun 2001|권=276|호=22|쪽=19452–60|doi=10.1074/jbc.M101450200|pmid=11279203}}
* {{저널 인용|제목=Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor|저널=European Journal of Biochemistry / FEBS|날짜=Sep 2001|권=268|호=18|쪽=4860–7|doi=10.1046/j.0014-2956.2001.02407.x|pmid=11559354}}
* {{저널 인용|제목=Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs|저널=The Journal of Peptide Research|날짜=Feb 2002|권=59|호=2|쪽=55–61|doi=10.1046/j.1397-002x.2001.10946.x|pmid=11906607}}
* {{저널 인용|제목=Neurotensin counteracts apoptosis in breast cancer cells|저널=Biochemical and Biophysical Research Communications|날짜=Jul 2002|권=295|호=2|쪽=482–8|doi=10.1016/S0006-291X(02)00703-9|pmid=12150975}}
* {{저널 인용|제목=Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line|url=https://archive.org/details/sim_gastroenterology_2002-10_123_4/page/1135|저널=Gastroenterology|날짜=Oct 2002|권=123|호=4|쪽=1135–43|doi=10.1053/gast.2002.36000|pmid=12360476}}
* {{저널 인용|제목=Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation|저널=The Journal of Biological Chemistry|날짜=Mar 2004|권=279|호=13|쪽=12636–46|doi=10.1074/jbc.M303384200|pmid=14699144}}
* {{저널 인용|제목=Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor|url=https://archive.org/details/sim_journal-of-investigative-dermatology_2004-01_122_1/page/111|저널=The Journal of Investigative Dermatology|날짜=Jan 2004|권=122|호=1|쪽=111–8|doi=10.1046/j.0022-202X.2003.22131.x|pmid=14962098}}
* {{저널 인용|제목=Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation|저널=American Journal of Physiology. Gastrointestinal and Liver Physiology|날짜=Apr 2005|권=288|호=4|쪽=G621–9|doi=10.1152/ajpgi.00140.2004|pmid=15764810}}
{{참고 자료 끝}}

[[분류:G 단백질 연결 수용체]]
[[분류:인간 20번 염색체상 유전자]]