{{위키데이터 속성 추적}}
'''현창기'''(玄昌騎, Hyun Chang-Kee, 1963년- )는 대한민국의 교수이다. [[한동대학교]] 생명과학부 교수로 있으며 대사생화학 분야를 전공하고 있다. 관심 연구분야는 인슐린 저항성, 대사이상 지방간질환 등의 발병 분자기전에 기반한 치료제 개발, 대사질환과 염증성 장질환 간의 연계 기전, 장내균총 교란 관련 발병 및 치료 기전 등이다. 또한 기독교 세계관 및 기원과학 분야에도 관심을 두고 무신론적 진화론에 대한 비판적 고찰과 유신론적 과학이론의 대안적 제안 등에 대한 연구와 집필 활동을 수행해왔다.

==학력==
* 서울대학교 학사
*  KAIST 박사

==경력==
* 1995~현재 한동대학교 생명과학부 교수
==논문==
===해외학술지===
* Kim B, Ronaldo R, Kweon BN, Yoon S, Park Y, Baek JH, Lee JM, Hyun CK. Mesenchymal Stem Cell-Derived Exosomes Attenuate Hepatic Steatosis and Insulin Resistance in Diet-Induced Obese Mice by Activating the FGF21-Adiponectin Axis. International Journal of Molecular Sciences 27(19), 10447 (2024)
* Lee C, Kim S, Kim B, Holzapfel WH, Hyun CK. Disturbance of lipid metabolism in germ-free mice transplanted with gut microbiota of DSS-induced colitis mice. PLoS One 18(2), e0280850 (2023)
*  Hyun CK. Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases. International Journal of Molecular Sciences 22(17), 9139 (2021)
*  Kwon J, Lee C, Heo S, Kim B, Hyun CK. DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice. Scientific Reports 11(1), 5283 (2021)
* Kim B, Hyun CK. B-cell-activating factor depletion ameliorates aging-dependent insulin resistance via enhancement of thermogenesis in adipose tissues. International Journal of Molecular Sciences 21(14), 5121 (2020)
* Kwon J, Kim B, Lee C, Joung H, Kim BK, Choi IS, Hyun CK. Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice. PLoS One 15(2), e0228932 (2020)
*  Ji Y et al., Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model. Scientific Reports 9(1), 6821 (2019)
* Kim KD et al., Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK. Nutrition, Metabolism and Cardiovascular Diseases 29(4), 409-420 (2019)
*  Kim B, Kwon J, Kim MS, Park H, Ji Y, Holzapfel W, Hyun CK. Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice. PLoS One 13(12), e0210120 (2018)
* Jung HY et al., Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice. Diabetes, Obesity and Metabolism 20(7), 1688-1701 (2018)
*  Kim MS et al., Long-term fermented soybean paste improves metabolic parameters associated with non-alcoholic fatty liver disease and insulin resistance in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications 495, 1744-1751 (2018)
*  Kim B et al., Syringin attenuates insulin resistance via adiponectin-mediated suppression of low-grade chronic inflammation and ER stress in high-fat diet-fed mice. Biochemical and Biophysical Research Communications 488, 40-45 (2017)
* Park S et al., Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model. Applied Microbiology and Biotechnology 101, 1605-1614 (2017)
* Kim B, Hyun CK. Gender-Specific Mechanisms Underlying the Amelioration of High-Fat Diet-Induced Glucose Intolerance in B-Cell-Activating Factor Deficient Mice. PLoS One 11(11), e0166225 (2016)
* Kim B et al., Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice. Biochemical and Biophysical Research Communications 473, 530-536 (2016)
* Kim B et al., B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function. Biochemical and Biophysical Research Communications 464, 1171-1177 (2015)
* Park KY et al., Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice. Journal of Clinical Biochemistry and Nutrition 56(3), 240-246 (2015)
* Park KY et al., Lactobacillus rhamnosus GG reverses insulin resistance but does not block its onset in diet-induced obese mice. Journal of Microbiology and Biotechnology 25(5), 753-757 (2015)
* Jung-Han Lee, Chang-Kee Hyun, Insulin-sensitizing and beneficial lipid-metabolic effects of water-soluble melanin complex extracted from Inonotus obliquus. Phytotherapy Research 28(9), 1320-1328 (2014)
* Sun-Woo Kim, Kun-Young Park, Bobae Kim, Eunha Kim, Chang-Kee Hyun. Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Biochemical and Biophysical Research Communications 431, 258-263 (2013)
* Eunha Kim, Jung-Han Lee, James M. Ntambi, Chang-Kee Hyun, Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro. European Journal of Pharmacology 672, 38-44 (2011)
* Eun-do Kim, Eunha Kim, Jung-Han Lee, James Ntambi, Chang-Kee Hyun,  Gly-Ala-Gly-Val-Gly-Tyr, a novel synthetic peptide, improves glucose transport and exerts beneficial lipid metabolic effects in 3T3-L1 adipoctyes. European Journal of Pharmacology 650, 479-485 (2011)
* Chang-Kee Hyun, Eun-Do Kim, Matthew T. Flowers, Xueqing Liu, Eunha Kim, Maggie Strable, and James M. Ntambi, Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochemical and Biophysical Research Communications 399(4), 480-486 (2010)
* Kim ED et al., Fibroin-derived peptides stimulate glucose transport in normal and insulin-resistant 3T3-L1 adipocytes. Biological and Pharmaceutical Bulletin 32(3), 427-433 (2009)
* Kim SH et al., Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes. Biological and Pharmaceutical Bulletin 30(11), 2120-2125 (2007)
* Choi BH et al., Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Experimental and Molecular Medicine 38, 599-605 (2006)
* Park KJ et al., Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells. Pharmacological Research 52, 346-352 (2005)
* Kim, IY, Hyun CK, Comparative evaluation of the alkaline comet assay with the micronucleus test for genotoxicity monitoring using aquatic organisms. Ecotoxicology and Environmental Safety, 64(3), 288-297(2006)
* Hyun CK, Kim IY, Frost SC, Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes. Journal of Nutrition 134, 3257-3263 (2004)
* Jin HH et al., Detection of DNA damage in carp using single-cell gel electrophoresis assay for genotoxicity monitoring. Journal of Microbiology and Biotechnology 14(2), 268-275 (2004)
* Park KJ et al., Antigenotoxicity of the peptides produced from silk fibroin. Process Biochemistry, 38, 411-418 (2002)
* Park KJ, Hyun CK, Production of antigenotoxic peptides from bovine blood plasma proteins. Enzyme and Microbial Technology 30(5), 633-638 (2002)
* Hyun CK, Shin HK, Utilization of bovine blood plasma proteins for the production of angiotensin I converting enzyme inhibitory peptides. Process Biochemistry 36, 65-71 (2000)
* Park JH et al., Cytotoxic effects of the components in heat-treated mistletoe (Viscum album). Cancer Letters 139, 207-213 (1999)
* Park JH et al., Cytotoxicity of heat-treated Korean mistletoe. Cancer Letters 126(1), 43-48 (1998)
* Hyun CK, Shin HK, Utilization of bovine blood proteins produced from slaughterhouse for the economic production of probiotics. Journal of Bioscience and Bioengineering 86(1), 34-37 (1998)
* Hyun, C.K., E. Tamiya, T. Takeuchi, I. Karube and N. Inoue, A novel BOD sensor based on bacterial luminescence. Biotechnology and Bioengineering 41(11), 1107-1111 (1993)
* Hyun, C.K., J.H. Kim and D.D.Y. Ryu, Enhancement effect of polyethylene glycol on enzymatic synthesis of cephalexin. Biotechnology and Bioengineering 41(6), 654-658 (1993)
* Hyun, C.K., J.H. Choi, J.H. Kim and D.D.Y. Ryu, Enhancement effect of water activity on enzymatic synthesis of cephalexin. Biotechnology and Bioengineering 42(7), 800-806 (1993)
* Hyun, C.K., J.H. Kim and Y.J. Kim, Effect of water activity on enzymatic synthesis of cephalexin. Biotechnology Letters 11(8), 537-540 (1989)
* Oh DK, Hyun CK, Kim JH, Production of penicillin in a fluidized-bed bioreactor: control of cell growth and penicillin production by phosphate limitation. Biotechnology and Bioengineering 32, 569-573 (1988)
'''국내학술지'''
* 김보배, 김민석, 현창기. 고지방식이 유도 비만 마우스에서 Inonotus obliquus의 체중 증가 억제 및 지방대사 개선 작용 (Suppression of Adiposity and Improvement of Fat Metabolism in High-fat Diet-induced Obese Mice Treated with an Inonotus obliquus Extract). 생약학회지 47(2), 172-178 (2016)
* 김보배, 현창기, 고지방식이 유도 비만 마우스에서 Acanthopanax senticusus의 지방축적 억제 및 인슐린 저항성 개선 작용. 생약학회지 46, 65-71 (2015)
* Kim, S. H., E. J. Shin, C. K. Hyun, 3T3-L1 지방세포에서 Phellodendri cortex의 glucose uptake 촉진 및 인슐린 저항성 개선 활성. 생약학회지 36, 291-298 (2005)
* Kim, I. Y. and C. K. Hyun, Single-cell Gel Electrophoresis Assay에 의한 Spisula sachalinensis에서의 in Vivo 유전독성 평가. 한국독성학회지 20, 225-232 (2004)
* Hong, S. E., K. J. Park, B. S. Suh, M. S. Do and C. K. Hyun, 실크 피브로인 산 가수분해물이 db/db mice의 지방세포 대사에 미치는 영향. 생약학회지 33(4), 313-318 (2002)
* Park, K. J. and C. K. Hyun, Stimulation of Nitric Oxide Production in RAW 264.7 Macrophages by the Peptides Derived from Silk Fibroin, 한국미생물생명공학회지 30(1), 39-45 (2002)
* Park, K. J., S. E. Hong, M. S. Do and C. K. Hyun, Streptozotocin 당뇨유발 쥐와 db/db 마우스에서의 피브로인 가수분해물에 의한 인슐린 분비 촉진, 생약학회지, 33(1), 22-28 (2002)
* 김해홍, 김동만, 현창기, Quinone reductase 유도활성 측정에 의한 약용식물의 항암활성 검색(Induction of quinone reductase by extracts of tranditional medicinal plants). 생약학회지 32(2), 168-174 (2001)
* Hyun, C. K., Applications of biosensors in environmental monitoring. 생물화공(Biochemical Engineering and Biotechnology) 8(2), 10-16
* Hyun, C. K. and H. K. Shin, Production of angiotensin I converting enzyme inhibitory peptides from bovine blood plasma proteins. 한국생물공학회지 14(5), 600-605 (1999) 외 다수
==번역서 및 저서==
*  정병갑, 정국현, 고석찬, 임헌만, 강병호, 현창기, 이명선, 정용석, 김철근, 이영섭, 장락우 공역, "MEET, DEET, GRE 준비를 위한 생화학 및 분자·세포생물학(Color Atlas of Biochemistry)", 월드사이언스, 2008년
* 현창기, 김종명, 김군도 공역, "신호전달(Signal Transduction)", 월드사이언스, 2009년
*  현창기, 도명술 공역, "위대한 설계, 그 흔적들 (Signs of Intelligence – Understanding Intelligent Design)", 새물결플러스, 2014년
* 현창기, 김기웅, 김은실, 김효정, 류현실, 정병윤, 이상찬 공저. "기독교 세계관으로 풀어보는 과학수업", DCTY (꿈을 이루는 사람들), 2014년
*  소현수, 현창기, 배성민, 김병훈 공역. "유신진화론 비판(Theistic Evolution: A Scientific, Philosophical, and Theological Critique)", 부흥과개혁사, 2019년
==논문==
* 현창기, 도명술, 생명복제에 대한 기독교적 고찰, 통합연구 12(1), 81-105 (1999)
*  현창기, Mitochondria 및 mitochondrial ribosome의 endosymbiosis 진화가설에 대한 비판적 고찰, 통합연구 18(2), 131-154 (2005)
* 현창기, 줄기세포를 이용한 난치병 치료 연구의 현황. In '줄기세포연구와 난치병 치료' 배아복제를 반대하는 과학자모임 기획, pp.77-108 (2006)
*  전동규, 현창기, 초소형 분자 모터 ATP synthase에 대한 지적설계 논증, 지적설계연구회 심포지움, 2008년 2월
* 최훈, 현창기, Proopiomelanocortin - prohormone convertase 상호작용에 기초한 지적설계 논증, 지적설계연구회 심포지움 논문집, 2010년 2월
* 류현실, 현창기, 기독교 세계관에 기초한 초등과학교과 물 관련 단원의 이론적 탐색과 개발의 틀. 신앙과 학문 17(3), 115-143 (2012)
* 이나연, 현창기, B 세포 성숙기작을 이용한 신다윈주의 자연선택 진화모델에 대한 비판적 고찰. 신앙과 학문 19(1), 97-115 (2014)
*  김아람, 현창기, 인간 유전체 ENCODE 프로젝트와 정크 DNA의 기능성 논쟁에 대한 기원과학적 고찰. 신앙과 학문 21(3), 7-35 (2016)
== 같이 보기 ==
* [[현창학]]

[[분류:서울대학교 동문]]
[[분류:생화학자]]