{{위키데이터 속성 추적}}
{{Infobox_gene}}
'''사이토글로빈'''({{llang|en|cytoglobin}})은 [[사람]]과 [[포유류]]의 [[유전자]]인 CYGB의 [[단백질]] 산물이다.<ref name="entrez"/>

사이토글로빈은 모든 조직에서 발현되며, 특히 [[해양 포유류]]에서 가장 많이 활용되는 [[글로빈]] 분자이다. 사이토글로빈은 2001년에 발견되었으며,<ref>{{저널 인용| vauthors = Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K | title = Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 25318–23 | date = Jul 2001 | pmid = 11320098 | doi = 10.1074/jbc.M102630200 | doi-access = free }}</ref> 2002년에 사이토글로빈으로 명명되었다.<ref>{{저널 인용| vauthors = Burmester T, Ebner B, Weich B, Hankeln T | title = Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues | journal = Molecular Biology and Evolution | volume = 19 | issue = 4 | pages = 416–21 | date = Apr 2002 | pmid = 11919282 | doi = 10.1093/oxfordjournals.molbev.a004096 | doi-access = free }}</ref> 사이토글로빈은 [[저산소증]]으로부터 보호하는 역할을 하는 것으로 생각된다. 사이토글로빈의 예상되는 기능은 [[동맥혈]]에서 [[뇌]]로 [[산소]]를 전달하는 것이다.<ref name="sciencedaily">{{웹 인용| title = Why Diving Marine Mammals Resist Brain Damage from Low Oxygen| url= https://www.sciencedaily.com/releases/2007/12/071218192033.htm | work = ScienceDaily | date = 20 December 2007 }}</ref>

== 기능 ==
사이토글로빈은 [[조직 (생물학)|조직]]을 통한 산소의 확산을 촉진하고 [[산화 질소]] 또는 [[활성 산소]]를 제거하거나 [[산화 스트레스]] 동안 보호 기능을 제공할 수 있는 어디에서나 발현되는 [[배위수|6배위]] [[헤모글로빈]]이다.<ref name="entrez">{{웹 인용| title = Entrez Gene: CYGB cytoglobin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114757 }}</ref><ref name="Trent_2002">{{저널 인용| vauthors = Trent JT, Hargrove MS | title = A ubiquitously expressed human hexacoordinate hemoglobin | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19538–45 | date = May 2002 | pmid = 11893755 | doi = 10.1074/jbc.M201934200 | doi-access = free }}</ref>

== 활용 ==
CYGB 발현은 손상된 사람의 [[간]]의 [[간 성상세포]]와 간문맥 [[근섬유아세포]]를 구별할 수 있는 특정 마커로 사용될 수 있다.<ref name="pmid24296877">{{저널 인용| vauthors = Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N | title = Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver | journal = Laboratory Investigation | volume = 94 | issue = 2 | pages = 192–207 | date = Feb 2014 | pmid = 24296877 | doi = 10.1038/labinvest.2013.135 | doi-access = free }}</ref>

== 같이 보기 ==
* [[글로빈]]
* [[헤모글로빈]]
* [[미오글로빈]]
* [[뉴로글로빈]]
* [[피토글로빈]]
* [[레그헤모글로빈]]

== 각주 ==
{{각주}}

== 더 읽을거리 ==
{{참고 자료 시작| 2}}
* {{저널 인용| vauthors = Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K | title = Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 25318–23 | date = Jul 2001 | pmid = 11320098 | doi = 10.1074/jbc.M102630200 | doi-access = free }}
* {{저널 인용| vauthors = Burmester T, Ebner B, Weich B, Hankeln T | title = Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues | journal = Molecular Biology and Evolution | volume = 19 | issue = 4 | pages = 416–21 | date = Apr 2002 | pmid = 11919282 | doi = 10.1093/oxfordjournals.molbev.a004096 | doi-access = free }}
* {{저널 인용| vauthors = Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K | title = Characterization of human stellate cell activation-associated protein and its expression in human liver | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1577 | issue = 3 | pages = 471–5 | date = Sep 2002 | pmid = 12359339 | doi = 10.1016/s0167-4781(02)00477-3 }}
* {{저널 인용| vauthors = Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, Shiro Y | title = Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans | journal = Biochemistry | volume = 42 | issue = 17 | pages = 5133–42 | date = May 2003 | pmid = 12718557 | doi = 10.1021/bi027067e }}
* {{저널 인용| vauthors = Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, Moens L | title = A globin in the nucleus! | journal = The Journal of Biological Chemistry | volume = 278 | issue = 33 | pages = 30417–20 | date = Aug 2003 | pmid = 12796507 | doi = 10.1074/jbc.C300203200 | doi-access = free }}
* {{저널 인용| vauthors = Hamdane D, Kiger L, Dewilde S, Green BN, Pesce A, Uzan J, Burmester T, Hankeln T, Bolognesi M, Moens L, Marden MC | title = The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51713–21 | date = Dec 2003 | pmid = 14530264 | doi = 10.1074/jbc.M309396200 | doi-access = free }}
* {{저널 인용| vauthors = Schmidt M, Gerlach F, Avivi A, Laufs T, Wystub S, Simpson JC, Nevo E, Saaler-Reinhardt S, Reuss S, Hankeln T, Burmester T | title = Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia | journal = The Journal of Biological Chemistry | volume = 279 | issue = 9 | pages = 8063–9 | date = Feb 2004 | pmid = 14660570 | doi = 10.1074/jbc.M310540200 | doi-access = free }}
* {{저널 인용| vauthors = Hünermund G, Schirmacher A, Ringelstein B, Young P, Watts GD, Meuleman J, Nelis E, Chance PF, Timmerman V, Stögbauer F, Kuhlenbäumer G | title = Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy | journal = Muscle & Nerve | volume = 29 | issue = 4 | pages = 601–4 | date = Apr 2004 | pmid = 15052627 | doi = 10.1002/mus.20009 | s2cid = 39945876 }}
* {{저널 인용| vauthors = de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M | title = Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination | journal = Journal of Molecular Biology | volume = 336 | issue = 4 | pages = 917–27 | date = Feb 2004 | pmid = 15095869 | doi = 10.1016/j.jmb.2003.12.063 | s2cid = 21144924 }}
* {{저널 인용| vauthors = Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y | title = Structural basis of human cytoglobin for ligand binding | journal = Journal of Molecular Biology | volume = 339 | issue = 4 | pages = 873–85 | date = Jun 2004 | pmid = 15165856 | doi = 10.1016/j.jmb.2004.04.024 }}
* {{저널 인용| vauthors = Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber RE | title = Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance | journal = The Journal of Biological Chemistry | volume = 279 | issue = 43 | pages = 44417–26 | date = Oct 2004 | pmid = 15299006 | doi = 10.1074/jbc.M407126200 | doi-access = free }}
* {{저널 인용| vauthors = Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, Moens L, Marden MC | title = Hyperthermal stability of neuroglobin and cytoglobin | journal = The FEBS Journal | volume = 272 | issue = 8 | pages = 2076–84 | date = Apr 2005 | pmid = 15819897 | doi = 10.1111/j.1742-4658.2005.04635.x | s2cid = 13377138 | doi-access = free }}
* {{저널 인용| vauthors = Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, Kawada N, Yoshizato K, Kitagawa T, Shiro Y | title = Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin | journal = Biochemistry | volume = 44 | issue = 40 | pages = 13257–65 | date = Oct 2005 | pmid = 16201751 | doi = 10.1021/bi050997o }}
* {{저널 인용| vauthors = Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM | title = Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing | journal = British Journal of Cancer | volume = 94 | issue = 4 | pages = 561–8 | date = Feb 2006 | pmid = 16449996 | pmc = 2361183 | doi = 10.1038/sj.bjc.6602972 }}
* {{저널 인용| vauthors = McRonald FE, Liloglou T, Xinarianos G, Hill L, Rowbottom L, Langan JE, Ellis A, Shaw JM, Field JK, Risk JM | title = Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression | journal = Human Molecular Genetics | volume = 15 | issue = 8 | pages = 1271–7 | date = Apr 2006 | pmid = 16510494 | doi = 10.1093/hmg/ddl042 | doi-access = free }}
* {{저널 인용| vauthors = Xinarianos G, McRonald FE, Risk JM, Bowers NL, Nikolaidis G, Field JK, Liloglou T | title = Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer | journal = Human Molecular Genetics | volume = 15 | issue = 13 | pages = 2038–44 | date = Jul 2006 | pmid = 16698880 | doi = 10.1093/hmg/ddl128 | doi-access = free }}
{{참고 자료 끝}}

== 외부 링크 ==
* {{MeshName|cytoglobin}}

{{PDB Gallery|geneid=114757}}
{{헴단백질}}

[[분류:인간 17번 염색체상 유전자]]
[[분류:헴 단백질]]