{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 455249171
| IUPAC_name = 7-[(3-Chloro-6-methyl-5,5-dioxo-11''H''-benzo[''c''][2,1]benzothiazepin-11-yl)amino]heptanoic acid
| image = Tianeptine2DACS.svg
| width = 225px
| image2 =
| width2 = 225px

<!--Clinical data-->
| tradename = Stablon, Coaxil, others
| Drugs.com = {{drugs.com|international|tianeptine}}
| legal_status = In general: Rx-only<br>[[미국|US]]: not FDA approved, unscheduled<br>[[Australia|AU]]: [[Standard for the Uniform Scheduling of Medicines and Poisons#Schedule 4: Prescription only medicine|S4]]<ref>[https://www.legislation.gov.au/Details/F2017L00605]</ref><br>Others: controlled in  [[France|FR]], [[Bahrain|BH]], [[Singapore|SG]])
| routes_of_administration = [[Oral administration|By mouth]]

<!--Pharmacokinetic data-->
| bioavailability = 99%<ref name="pmid3180120">{{저널 인용|author1=Royer, RJ |author2=Albin, H |author3=Barrucand, D |author4=Salvadori-Failler, C |author5=Kamoun, A |title = Pharmacokinetic and metabolic parameters of tianeptine in healthy volunteers and in populations with risk factors | journal = Clinical Neuropharmacology | volume = 11 Suppl 2 | issue = | pages = S90–6 | year = 1988 | pmid = 3180120 | doi = | url = }}</ref><ref name = Tian2001>{{저널 인용|title=Tianeptine A Review of its Use in Depressive Disorders|journal=CNS Drugs|date=March 2001|volume=15|issue=3|doi=10.2165/00023210-200115030-00006|pages=231–259|pmid=11463130|author1=Wagstaff, AJ |author2=Ormrod, D |author3=Spencer, CM }}</ref>
| protein_bound = 95%<ref name = Tian2001/>
| metabolism = [[Hepatic]]<ref name = Tian2001/>
| elimination_half-life = 2.5–3 hours<ref name="pmid3180120" /><ref name = Tian2001/><br />4–9 hours ([[elderly]])<ref name =Tian2001/><ref name="CarlhantLeGarrec1990">{{저널 인용|title=Pharmacokinetics and bioavailability of tianeptine in the elderly|journal=Drug Investigation|date=September 1990|volume=2|issue=3|pages=167–172|doi=10.1007/BF03259191|author1=Carlhant, D |author2=Le Garrec, J |author3=Guedes, Y |author4=Salvadori, C |author5=Mottier, D |author6=Riche, C }}</ref>
| excretion = [[Urine]]: 65%<ref name="pmid3180120" /><br />[[Feces]]: 15%<ref name =Tian2001/>

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 66981-73-5
| CAS_supplemental = <br />30123-17-2 ([[sodium]])<br />1224690-84-9 ([[sulfate]])
| ATC_prefix = N06
| ATC_suffix = AX14
| PubChem = 68870
| IUPHAR_ligand = 7558
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 62102
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1289110
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 0T493YFU8O
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02575
| synonyms = S-1574;<ref name="Elks2014">{{서적 인용|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA1195|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=1195–}}</ref><ref name="IndexNominum2000">{{서적 인용|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1024|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1024–}}</ref><ref name="Drugs.com">https://www.drugs.com/international/tianeptine.html</ref> JNJ-39823277; TPI-1062<ref name="AdisInsight">{{웹 인용| title = Tianeptine - AdisInsight | author = AdisInsight | publisher = Springer | url = http://adisinsight.springer.com/drugs/800039841 | accessdate = 31 January 2016}}</ref>

<!--Chemical data-->
| C=21 | H=25 | Cl=1 | N=2 | O=4 | S=1
| molecular_weight = 458.933 g/mol
| SMILES = Clc1cc2c(cc1)C(c3c(N(C)S2(=O)=O)cccc3)NCCCCCCC(=O)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C21H24ClN2NaO4S/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JICJBGPOMZQUBB-UHFFFAOYSA-N
}}
'''티아넵틴'''(Tianeptine, 상품명으로 '스타브론' 등이 사용된다)은 국내 업체인 [[제일약품]]에서 생산하는 항우울제이다.

== 작용 기전 ==
티아넵틴은 글루타메이트 조절제로 과활성화된 HPA 축에 의한 글루타메이트를 정상화시켜 신경가소성을 회복시키는 기전의 항우울제이다. 전형적인 삼환계 항우울제(TCA)와는 달리, AMPA, NMDA 수용체 및 아편 수용체에도 작용하여 항불안, 항경련, 진통작용을 가진다. 기존 세로토닌과 노르에피네프린 등에 작용하는 기존 항우울제와 다른 기전으로 작용한다. 긴장, 고통, 통증을 유발하는 신경전달물질인 글루타메이트를 줄여주는 역할을 하므로, 우울증 완화 뿐만 아니라 [[불안 장애]] 완화 효과도 동시에 가지고 있다.

더욱이, 노인성 우울 장애 완화는 물론 인지기능개선에 도움돼 치매 및 기억력 저하를 예방하여, 집중인지장애에 효과적인 약물로 판단되어, 임상적으로 가장 효과적인 약제로 입증되었다.

== 각주 ==
{{각주}}

{{항우울제}}

[[분류:아민]]
[[분류:항불안제]]
[[분류:클로로아렌]]
[[분류:도취제]]
[[분류:뮤 오피오이드 수용체 작용제]]
[[분류:삼환계 항우울제]]
[[분류:트라이케톤]]