{{위키데이터 속성 추적}}
{{Infobox drug
| Verifiedfields    = changed
| verifiedrevid     = 470604083
| drug_name         = 
| INN               = sapropterin
| type              = <!-- empty -->
| image             = Tetrahydrobiopterin structure.png
| width             = 
| alt               = 
| caption           = 
| JAN               = Sapropterin hydrochloride
| USAN              = Sapropterin dihydrochloride

<!-- Clinical data -->
| pronounce         = 
| tradename         = Kuvan, Biopten
| Drugs.com         = {{drugs.com|monograph|sapropterin-dihydrochloride}}
| MedlinePlus       = a608020
| licence_CA        = <!-- Health Canada may use generic or brand name (generic name preferred) -->
| licence_EU        = yes
| DailyMedID        = Sapropterin
| licence_US        = Sapropterin
| pregnancy_AU      = B1
| pregnancy_AU_comment =<ref name="Drugs.com pregnancy">{{웹 인용| title=Sapropterin (Kuvan) Use During Pregnancy | website=Drugs.com | date=17 May 2019 | url=https://www.drugs.com/pregnancy/sapropterin.html | access-date=4 March 2020}}</ref>
| pregnancy_US      = C
| pregnancy_US_comment =<ref name="Drugs.com pregnancy" />
| pregnancy_category= 
| dependency_liability = 
| addiction_liability = 
| routes_of_administration = [[Oral administration|By mouth]]
| class             = 
| ATCvet            = 
| ATC_prefix = A16
| ATC_suffix = AX07
| ATC_supplemental  =

<!-- Legal status -->
| legal_AU = S4
| legal_AU_comment = 
| legal_BR =  <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F-->
| legal_BR_comment = 
| legal_CA = Rx-only
| legal_CA_comment = 
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment = 
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment = 
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment = 
| legal_US = Rx-only
| legal_US_comment = 
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment = 
| legal_status      = Rx-only

<!-- Pharmacokinetic data -->
| bioavailability   = 
| protein_bound     = 
| metabolism        = 
| metabolites       = 
| onset             = 
| elimination_half-life = 4 hours (healthy adults)<br />6–7 hours ([[Phenylketonuria|PKU]] patients)
| duration_of_action = 
| excretion         =

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 62989-33-7
| CAS_supplemental  = 
| PubChem = 135398654
| IUPHAR_ligand = 5276
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00360
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 40270
| UNII_Ref          = 
| UNII              = EGX657432I
| KEGG_Ref          = 
| KEGG              = D08505
| KEGG2_Ref         = 
| KEGG2             = C00272
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 59560
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201774
| NIAID_ChemDB      = 
| PDB_ligand        = H4B
| synonyms          =

<!-- Chemical and physical data -->
| IUPAC_name        = (6''R'')-2-Amino-6-[(1''R'',2''S'')-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1''H'')-one
| chemical_formula  = 
| C=9 | H=15 | N=5 | O=3
| SMILES            = CC(C(C1CNC2=C(N1)C(=O)N=C(N2)N)O)O
| Jmol              = 
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
| StdInChI_comment  = 
| StdInChIKey_Ref   = {{stdinchicite|correct|chemspider}}
| StdInChIKey       = FNKQXYHWGSIFBK-RPDRRWSUSA-N
| density           = 
| density_notes     = 
| melting_point     = 
| melting_high      = 
| melting_notes     = 
| boiling_point     = 
| boiling_notes     = 
| solubility        = 
| sol_units         = 
| specific_rotation = 
}}

'''테트라하이드로비오프테린'''({{llang|en|tetrahydrobiopterin}}, '''BH<sub>4</sub>''', '''THB''')은 아미노산인 [[페닐알라닌]]의 분해 및 [[신경전달물질]]인 [[세로토닌]](5-하이드록시트립타민, 5-HT), [[멜라토닌]], [[도파민]], [[노르에피네프린]], [[에피네프린]]의 [[생합성]]에 사용되는 [[비오프테린-의존성 방향족 아미노산 하이드록실화효소]]의 [[보조 인자]]이다<ref name="Cara">{{저널 인용|title=Pterin-Dependent Amino Acid Hydroxylases|journal=Chemical Reviews|date=November 1996|volume=96|issue=7|pages=2659–2756|doi=10.1021/CR9402034|pmid=11848840|vauthors=Kappock TJ, Caradonna JP}}</ref> '''사프로프테린'''({{llang|en|sapropterin}})이라고도 한다.<ref>{{웹 인용| title=Sapropterin | website=Drugs.com | date=28 February 2020 | url=https://www.drugs.com/international/sapropterin.html | access-date=4 March 2020 }}</ref><ref>{{웹 인용 | title=International Non-proprietary Names for Pharmaceutical Substances (INN) | website=Fimea | url=https://www.fimea.fi/web/en/supervision/legislation/european_pharmacopoeia/international-non-proprietary-names-for-pharmaceutical-substances-inn- | access-date=4 March 2020 | archive-date=2020-10-01 | archive-url=https://web.archive.org/web/20201001075302/https://www.fimea.fi/web/en/supervision/legislation/european_pharmacopoeia/international-non-proprietary-names-for-pharmaceutical-substances-inn- | url-status= }}</ref> 또한 테트라하이드로비오프테린은 [[산화 질소 생성효소]]에 의한 [[산화 질소]]의 생성을 위한 보조 인자이다.<ref>{{저널 인용| vauthors = Całka J | title = The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons | journal = Folia Histochemica et Cytobiologica | volume = 44 | issue = 1 | pages = 3–12 | year = 2006 | pmid = 16584085 | url = http://czasopisma.viamedica.pl/fhc/article/view/4581 }}</ref> 화학적으로 그 구조는 다이하이드로프테리딘 환원효소에 의해 환원된 [[프테리딘]] 유도체(퀴노노이드 다이하이드로비오프테린)이다.<ref>{{서적 인용|last=Bhagavan|first=N. V.|title=Essentials of Medical Biochemistry With Clinical Cases, 2nd Edition|publisher=Elsevier|year=2015|isbn=978-0-12-416687-5|location=USA|pages=256}}</ref>

== 같이 보기 ==
* [[보조 인자]]
* [[테트라하이드로메타노프테린]]

== 각주 ==
{{각주}}

{{효소 보조 인자}}
{{기타 소화관 및 대사산물}}

[[분류:조효소]]
[[분류:락탐]]
[[분류:희귀약]]
[[분류:프테리딘]]
[[분류:비시날 다이올]]