{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 457629722
| drug_name = 
| IUPAC_name = <nowiki>methyl 7-chloro-6,7,8-trideoxy-6-{[(4</nowiki>''R'')-1-methyl-4-propyl-<small>L</small>-prolyl]amino}-1-thio-<small>L</small>-threo-α-<small>D</small>-galacto-octopyranoside
| image = Clindamycin Structural Formula V2.svg
| width = 250
| image2 = Clindamycin 3D 3jz0.png
| width2 = 250

<!--Clinical data-->
| pronounce = {{IPAc-en|k|l|ɪ|n|d|ə|ˈ|m|aɪ|s|ᵻ|n}}
| tradename = Cleocin, Clinacin, Dalacin, others
| Drugs.com = {{drugs.com|monograph|clindamycin-hydrochloride}}
| class     = [[:en:Lincosamides|Lincosamide antibiotic]]
| MedlinePlus = a682399
| licence_US = Clindamycin
| pregnancy_AU = A
| pregnancy_US = B
| legal_AU = S4
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = by mouth, [[:en:topical]], [[수액 (의학)|IV]], [[:en:pessary|intravaginal]]

<!--Pharmacokinetic data-->
| bioavailability = 90% (by mouth)<br />4–5% (topical)
| protein_bound = 95%
| metabolism = [[간|Hepatic]]
| elimination_half-life = 2–3 hours
| excretion = Biliary and [[콩팥|renal]] (around 20%)
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 18323-44-9
| ATC_prefix = J01
| ATC_suffix = FF01
| ATC_supplemental = {{ATC|D10|AF01}} {{ATC|G01|AA10}}
| PubChem = 446598
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01190
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 393915
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 3745
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3U02EL437C
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00277
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1753

<!--Chemical data-->
| C=18 | H=33 | Cl=1 | N=2 | O=5 | S=1
| molecular_weight = 424.98 g/mol
| smiles = Cl[C@@H](C)[C@@H](NC(=O)[C@H]1N(C)C[C@H](CCC)C1)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = KDLRVYVGXIQJDK-AWPVFWJPSA-N
| synonyms = 7-chloro-lincomycin<br />7-chloro-7-deoxylincomycin
|alt=|caption=|type=|legal_status=|licence_EU=|pregnancy_category=
}}

'''클린다마이신'''({{lang|en|clindamycin}})은 수많은 [[병균 감염]] 치료에 유용한 [[항생물질]]이다.<ref name=AHFS2015>{{웹 인용|title=Clindamycin Hydrochloride |url=https://www.drugs.com/monograph/clindamycin-hydrochloride.html |publisher=The American Society of Health-System Pharmacists |accessdate=Sep 4, 2015 |url-status=live |archiveurl=https://web.archive.org/web/20150905150900/http://www.drugs.com/monograph/clindamycin-hydrochloride.html |archivedate=2015-09-05 |df=}}</ref> 여기에는 [[중이염]], 뼈 및 [[화농성 관절염]], [[골반염]], [[연쇄상 구균 인두염]], [[폐렴]], [[심장 내막염]] 등이 포함된다.<ref name=AHFS2015/> 일부 케이스의 [[메티실린 내성 황색포도상구균]](MRSA)에 유용하다.<ref name=Daum2007>{{저널 인용|author=Daum RS |title=Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus |journal=[[:en:New England Journal of Medicine|N Engl J Med]] |volume=357 |issue=4 |pages=380–90 |year=2007 |pmid=17652653 |doi=10.1056/NEJMcp070747}}</ref> [[여드름]]에 대해 사용할 수 있고, 그 외에 [[말라리아]]의 경우 [[퀴닌]]과 함께 사용할 수도 있다.<ref name=AHFS2015/><ref name=Ley2006/> 구강으로, [[수액 (의학)|정맥 주사]]로, 또 피부나 질에 크림을 바름으로써 사용할 수 있다.<ref name=AHFS2015/><ref name=Ley2006>{{서적 인용|last1=Leyden |first1=James J. |title=Hidradenitis suppurativa |date=2006 |publisher=Springer |location=Berlin |isbn=9783540331018 |page=152 |url=https://books.google.com/books?id=hpKFsXwcKlgC&pg=PA152 |url-status=live |df= |archiveurl=https://web.archive.org/web/20170908162632/https://books.google.com/books?id=hpKFsXwcKlgC&pg=PA152 |archivedate=2017-09-08}}</ref>

일반적인 부작용으로는 메스꺼움, 설사, 발진, 주사 부위의 통증이 포함된다.<ref name=AHFS2015/> 병원감염(HA) [[클로스트리디움 디피실 감염증]] 위험이 4배로 증가한다.<ref name=Thomas>{{저널 인용|vauthors=Thomas C, Stevenson M, Riley TV |title=Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review |journal=J Antimicrob Chemother |volume=51 |issue=6 |pages=1339–50 |year=2003 |pmid=12746372 |doi=10.1093/jac/dkg254 |url=http://jac.oxfordjournals.org/content/51/6/1339.full.pdf |url-status=live |archiveurl=https://web.archive.org/web/20160107115031/http://jac.oxfordjournals.org/content/51/6/1339.full.pdf |archivedate=2016-01-07 |df= }}</ref> 이러한 이유로 다른 항생제들이 권고될 수 있다.<ref name=AHFS2015/> 임신 중에 복용 시 일반적으로 안전한 것으로 간주된다.<ref name=AHFS2015/> [[린코사미드|린코사미드계]] 약물에 속하며 박테리아가 단백질을 생성하지 못하게 막음으로써 동작한다.<ref name=AHFS2015/>

클린다마이신은 1966년 또는 1967년에 처음 개발되었다.<ref>{{서적 인용|title=Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life|date=2014|publisher=John Wiley & Sons|isbn=9781118819517|page=162|edition= 7|url=https://books.google.com/books?id=EORvBAAAQBAJ&pg=PA162|url-status=live|archiveurl=https://web.archive.org/web/20170908162632/https://books.google.com/books?id=EORvBAAAQBAJ&pg=PA162|archivedate=2017-09-08|df=}}</ref><ref>{{저널 인용|last1=Smieja |first1=M. |date=January–February 1998 |title= Current indications for the use of clindamycin: A critical review |journal=Can J Infect Dis|volume=9 |issue=1 |pages=22–28 |pmid=22346533 |pmc=3250868|doi=10.1155/1998/538090 }}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List) |url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1 |work=World Health Organization |accessdate=8 December 2016 |date=April 2015 |url-status=live |archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1 |archivedate=13 December 2016 |df=}}</ref> [[제네릭 의약품]]으로 구매가 가능하며 그다지 비싸지 않다.<ref name=Ric2015>{{서적 인용|last1=Hamilton |first1=Richart |title=Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition |date=2015 |publisher=Jones & Bartlett Learning |isbn=9781284057560 |page=108}}</ref> [[개발도상국]]의 도매가는 한 알약 당 대략 US$0.06–0.12이다.<ref name=ERC2014>{{웹 인용|title=Clindamycin|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=1011&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=6 September 2015|url-status=dead|archiveurl=https://web.archive.org/web/20160107115031/http://mshpriceguide.org/en/single-drug-information/?DMFId=1011&searchYear=2014|archivedate=7 January 2016|df=}}</ref> 미국내 비용은 1회 복용량 기준 대략 $2.70이다.<ref name=AHFS2015/> 2016년에, 미국에서 400만 건 이상의 처방과 더불어 151번째로 많이 처방을 받은 약물이었다.<ref>{{웹 인용|title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}}</ref>

== 합성 ==
[[파일:Clindamycin phosphate Structural Formula V2.svg|섬네일|왼쪽|클린다마이신의 합성<ref name="RxList">{{웹 인용|url=http://www.rxlist.com/clindamycin-phosphate-topical-solution-drug.htm|publisher=RxList|title=Clindamycin Phosphate Topical Solution|accessdate=2017-01-27|url-status=live|archiveurl=https://web.archive.org/web/20170202040857/http://www.rxlist.com/clindamycin-phosphate-topical-solution-drug.htm|archivedate=2017-02-02|df=}}</ref>]]
{{-}}

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://www.merck.com/mmpe/lexicomp/clindamycin.html Clindamycin drug information] from Lexi-Comp. Includes dosage information and a comprehensive list of international brand names.
* [https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0000437/ NCBI]

[[분류:세계 보건 기구 필수 의약품]]
[[분류:싸이오에터]]
[[분류:유기 염소 화합물]]
[[분류:알코올]]
[[분류:카복사마이드]]
[[분류:린코사마이드]]
[[분류:여드름 치료제]]