{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 459980153
| IUPAC_name = (''RS'')-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-<br/>3-(isopropylamino)propan-2-ol
| image = Bisoprolol.svg
| width = 240px
| chirality = [[라세미 혼합물]]
<!--Clinical data-->
| tradename = Zebeta, Concor, others
| Drugs.com = {{drugs.com|monograph|bisoprolol-fumarate}}
| MedlinePlus = a693024
| licence_US = Bisoprolol
| pregnancy_AU = C
| pregnancy_US = C
| pregnancy_category =  
| legal_status = Rx-only
| routes_of_administration = by mouth
<!--Pharmacokinetic data-->
| bioavailability = >90%
| protein_bound = 30%<ref name="pmid2439794">{{저널 인용|vauthors=Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A | title = Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans | journal = J. Cardiovasc. Pharmacol. | volume = 8 Suppl 11 | issue = | pages = S21–8 | year = 1986 | pmid = 2439794 | doi = 10.1097/00005344-198511001-00004| url = }}</ref>
| metabolism = 50% [[간]], [[:en:CYP2D6]], [[:en:CYP3A4]]<ref>{{저널 인용|title=Pharmacokinetics and metabolism of bisoprolol enantiomers in humans |author1=Yuji Horikiri |author2=Takehiko Suzuki |author3=Masakazu Mizobe |journal=Journal of Pharmaceutical Sciences |volume=87 |issue=3 |pages=289–294 |date=March 1998 |doi=10.1021/js970316d |pmid = 9523980|df= }}</ref>
| elimination_half-life = 10–12&nbsp;hours<ref name="pmid2439789">{{저널 인용| author = Leopold G | title = Balanced pharmacokinetics and metabolism of bisoprolol | journal = J. Cardiovasc. Pharmacol. | volume = 8 Suppl 11 | issue = | pages = S16–20 | year = 1986 | pmid = 2439789 | doi = 10.1097/00005344-198511001-00003| url = }}</ref>
<!--Identifiers-->
| IUPHAR_ligand = 7129
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 66722-44-9
| ATC_prefix = C07
| ATC_suffix = AB07
| PubChem = 2405
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00612
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2312
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = Y41JS2NL6U
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02342
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 3127
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 645
<!--Chemical data-->
| C=18 | H=31 | N=1 | O=4
| molecular_weight = 325.443 g/mol
| smiles = O(c1ccc(cc1)COCCOC(C)C)CC(O)CNC(C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VHYCDWMUTMEGQY-UHFFFAOYSA-N
}}

'''비소프롤롤'''({{lang|en|Bisoprolol}}, 상표명: '''Zebeta''' 등)은 대부분 [[심혈관계 질환]]을 위해 사용되는 약물이다.<ref name=AHFS2016/> 여기에는 특히 [[고혈압]], [[협심증|심장에 혈액이 충분히 공급되지 않은 데서 비롯되는 흉통]], [[심부전]]이 포함된다.<ref name=AHFS2016/><ref>{{웹 인용|title=Bisoprolol 2.5mg/5mg/10mg film coated tablet - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/25983|website=www.medicines.org.uk|accessdate=14 December 2016|date=18 February 2014|url-status=live|archiveurl=https://web.archive.org/web/20161220180258/https://www.medicines.org.uk/emc/medicine/25983|archivedate=20 December 2016|df=}}</ref> 구강으로 투여된다.<ref name=AHFS2016/>

일반적인 부작용으로는 두통, 피곤, 설사, [[주변부 부종|다리 부종]]이 포함된다.<ref name=AHFS2016/> 더 심각한 부작용으로는 [[천식]] 악화, [[저혈당증]] 인식 기능 차단, [[심부전]] 악화가 포함된다.<ref name=Pro2016>{{웹 인용|title=Bisoprolol - FDA prescribing information, side effects and uses|url=https://www.drugs.com/pro/bisoprolol.html|website=www.drugs.com|accessdate=14 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221004233/https://www.drugs.com/pro/bisoprolol.html|archivedate=21 December 2016|df=}}</ref> [[임신]] 중에 복용 시 태아에 위험할 수 있다는 염려가 있다.<ref>{{웹 인용|title=Bisoprolol (Zebeta) Use During Pregnancy|url=https://www.drugs.com/pregnancy/bisoprolol.html|website=www.drugs.com|accessdate=14 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221004229/https://www.drugs.com/pregnancy/bisoprolol.html|archivedate=21 December 2016|df=}}</ref> 비소프롤롤은 [[베타 차단제]]계 약물에 속하며 [[베타 차단제|β<sub>1</sub> 선택적]] 유형에 속한다.<ref name=AHFS2016>{{웹 인용|title=Bisoprolol Fumarate|url=https://www.drugs.com/monograph/bisoprolol-fumarate.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221004751/https://www.drugs.com/monograph/bisoprolol-fumarate.html|archivedate=21 December 2016|df=}}</ref>

비소프롤롤은 1976년에 특허를 받았으며 1986년 의학용으로 승인되었다.<ref name=Fis2006>{{서적 인용|last1=Fischer|first1=Janos|last2=Ganellin|first2=C. Robin|title=Analogue-based Drug Discovery|date=2006|publisher=John Wiley & Sons|isbn=9783527607495|page=461|url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA461|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170908140310/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA461|archivedate=2017-09-08|df=}}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}}</ref> 비소프롤롤은 [[제네릭 의약품]]으로 구매가 가능하다.<ref name=AHFS2016/> [[개발도상국]]의 도매가는 1개월 기준 대략 US$2.98–4.94이다.<ref name=ERC2014>{{웹 인용|title=Bisoprolol|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=1583&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=8 December 2016|보존url=https://web.archive.org/web/20181013094926/http://mshpriceguide.org/en/single-drug-information/?DMFId=1583&searchYear=2014|보존날짜=2018-10-13|url-status=dead}}</ref> 2015년 기준으로 미국내 비용은 1개월 간 $25–50이다.<ref name=Ric2015>{{서적 인용|last1=Hamilton|first1=Richart|title=Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition|date=2015|publisher=Jones & Bartlett Learning|isbn=9781284057560|page=151}}</ref> 2016년, 100만 건 이상의 처방과 더불어 미국에서 282번째로 처방을 많이 받은 약물이었다.<ref>{{웹 인용|title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{위키공용분류-줄}}

{{전거 통제}}

[[분류:베타 차단제]]
[[분류:에터]]
[[분류:페놀 에터]]
[[분류:알코올]]
[[분류:아민]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:아이소프로필 화합물]]