{{위키데이터 속성 추적}}
{{chembox
| verifiedrevid = 443851992
| name = 구아노신 이인산 만노스
| ImageFile = GDP-mannose.svg
| ImageSize = 250px
| IUPACName = [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate
| OtherNames = 
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 17372
| InChI = 1/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1
| InChIKey = MVMSCBBUIHUTGJ-GDJBGNAABK
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MVMSCBBUIHUTGJ-GDJBGNAASA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 3123-67-9
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = SA0B77H8CS
| PubChem = 18396
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 15820
| SMILES = O=P(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@@H]1O)CO)(O)OP(=O)(O)OC[C@H]4O[C@@H](n2c3NC(=N/C(=O)c3nc2)\N)[C@H](O)[C@@H]4O
| MeSHName = Guanosine+Diphosphate+Mannose
  }}
|Section2={{Chembox Properties
| Formula = C<sub>16</sub>H<sub>25</sub>N<sub>5</sub>O<sub>16</sub>P<sub>2</sub>
| MolarMass = 605.341 g/mol
| Appearance = 
| Density = 
| MeltingPt = 
| BoilingPt = 
  }}
|Section3={{Chembox Hazards
| MainHazards = 
| FlashPt = 
| AutoignitionPt = 
  }}
}}

'''구아노신 이인산 만노스'''({{llang|en|guanosine diphosphate mannose}}) 또는 '''GDP-만노스'''({{llang|en|GDP-mannose}})는 [[물질대사]]에서 [[글리코실트랜스퍼레이스]]가 촉매하는 반응의 기질로 사용되는 [[당뉴클레오타이드]]이다. GDP-만노스는 [[만노실트랜스퍼레이스]]라 불리는 [[효소]]의 [[반응물|기질]]이다.

모든 [[해당과정]]에서 활성화된 [[만노스]]의 공여체로 알려진 GDP-만노스는 [[진핵생물]]에서 필수적이다.<ref>{{저널 인용|last=Stewart|first=James|last2=Curtis|first2=Joan|last3=Spurck|first3=Timothy P.|last4=Ilg|first4=Thomas|last5=Garami|first5=Attila|last6=Baldwin|first6=Tracey|last7=Courret|first7=Nathalie|last8=McFadden|first8=Geoffrey I.|last9=Davis|first9=Antony|last10=Handman|first10=Emanuela|date=July 2005 |title=Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase|journal=International Journal for Parasitology|language=en|volume=35|issue=8|pages=861–873|doi=10.1016/j.ijpara.2005.03.008|pmid=15936761}}</ref>

== 생합성 ==
GDP-만노스는 [[만노스 1-인산 구아닐릴트랜스퍼레이스]]에 의해 [[구아노신 삼인산]](GTP)과 [[만노스 6-인산]]으로부터 생성된다.<ref name="Reeves">{{저널 인용|vauthors=Samuel G, Reeves P |title=Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly |journal=Carbohydrate Research |volume=338 |issue=23 |pages=2503–19 |year=2003 |pmid=14670712 |doi=10.1016/j.carres.2003.07.009}}</ref>

뉴클레오타이딜트랜스퍼레이스 계열의 효소 중 하나인 GDP-만노스 피로포스포릴레이스는 [[세균]], [[균류]], [[식물]], [[동물]]에서 발견되는 효소이다.<ref>{{저널 인용|last=Pomel|first=Sébastien|last2=Mao|first2=Wei|last3=Ha-Duong|first3=Tâp|last4=Cavé|first4=Christian|last5=Loiseau|first5=Philippe M.|date=2019-05-31|title=GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis|journal=Frontiers in Cellular and Infection Microbiology|volume=9|pages=186|doi=10.3389/fcimb.2019.00186|issn=2235-2988|pmc=6554559|pmid=31214516}}</ref>

== 같이 보기 ==
* [[구아노신 이인산]]
* [[만노스]]

== 각주 ==
{{각주}}

{{당뉴클레오타이드}}
{{전거 통제}}

[[분류:뉴클레오타이드]]
[[분류:조효소]]