{{위키데이터 속성 추적}}
{{다른 뜻 넘어옴|넥시엄|기업|NXIVM}}
{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477167063
| image = Esomeprazole.svg
| width = 245
| alt = 
| image2 = Esomeprazole ball-and-stick model.png
| width2 = 250
| alt2 =

<!--Clinical data-->
| pronounce = {{IPAc-en|ˌ|ɛ|s|oʊ|ˈ|m|ɛ|p|r|ə|ˌ|z|oʊ|l|,_|-|ˈ|m|iː|-|,_|-|ˌ|z|ɒ|l}}{{refn|{{MerriamWebsterDictionary|access-date=21 January 2016|Esomeprazole}}
}}
| tradename = 넥시움(Nexium) 등<ref name=brands>{{웹 인용| title = Esomeprazole Brand Names | date = 2011 | work = BDdrugs.com | location = Bangladesh | url = http://www.bddrugs.com/product5.php?idn=5&prev=&prev1=&prev2= | archive-url = https://web.archive.org/web/20120207193751/http://www.bddrugs.com/product5.php?idn=5&prev=&prev1=&prev2= | archive-date = 7 February 2012 }}</ref>
| Drugs.com = {{drugs.com|monograph|esomeprazole-magnesium}}
| MedlinePlus = a699054
| DailyMedID = Esomeprazole
| pregnancy_AU = B3
| pregnancy_AU_comment =<ref name=Preg2019 />
| routes_of_administration = [[경구 투여]], [[정맥 주사]]
| class            = [[양성자 펌프 억제제]]
| ATC_prefix = A02
| ATC_suffix = BC05

| legal_AU = S2
| legal_AU_comment = / &nbsp;S4 (Prescription Only Medicine)<ref>{{웹 인용| title=Esomeprazole | website=Therapeutic Goods Administration (TGA) | date=15 September 2017 | url=https://www.tga.gov.au/book-page/14-esomeprazole | access-date=19 July 2020}}</ref><ref>{{웹 인용| title=Toreso/Esocolam/Meprator/Esotor/Nesed/Esome/Esotrack (Torrent Australasia Pty Ltd) | website=Therapeutic Goods Administration (TGA) | date=16 February 2023 | url=https://www.tga.gov.au/resources/prescription-medicines-registrations/toresoesocolammepratoresotornesedesomeesotrack-torrent-australasia-pty-ltd | access-date=9 April 2023}}</ref>
| legal_CA          = Rx-only
| legal_CA_comment  =<ref>{{웹 인용| title=Product monograph brand safety updates | website=[[Health Canada]] | date=February 2024 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database/label-safety-assessment-update/product-monograph-brand-safety-updates.html | access-date=24 March 2024}}</ref>
| legal_UK = GSL
| legal_US = OTC
| legal_US_comment = /&nbsp;Rx-only<ref>{{웹 인용| title=Nexium- esomeprazole magnesium capsule, delayed release Nexium- esomeprazole magnesium granule, delayed release | work = DailyMed | publisher = U.S. Library of Medicine | date=7 June 2018 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4853677-1622-4037-688b-fdf533a11d96 | access-date=7 December 2020}}</ref><ref>{{웹 인용| title=Nexium 24HR- esomeprazole magnesium capsule, delayed release Nexium 24HR ClearMinis- esomeprazole magnesium capsule, delayed release | website=DailyMed | date=26 May 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4513934d-0cf0-40fc-a348-b4e75a33b094 | access-date=7 December 2020}}</ref><ref name="Nexium I.V. FDA label">{{웹 인용| title=Nexium I.V.- esomeprazole sodium injection| work = DailyMed | publisher = U.S. Library of Medicine | date=27 November 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c325bbfc-46f3-471e-7bbc-ed0d6965d13b | access-date=7 December 2020}}</ref>
| legal_EU = OTC
| legal_EU_comment =<ref>{{웹 인용| title=Nexium Control EPAR | website=[[European Medicines Agency]] (EMA) | date=17 September 2018 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/nexium-control | access-date=14 January 2021}}</ref>
| legal_status =

<!--Pharmacokinetic data-->
| bioavailability = 50~90%
| metabolism = [[간]] ([[CYP2C19]], [[CYP3A4]])
| elimination_half-life = 1~1.5시간
| excretion = 80% [[소변]]<br />20% [[대변]]

<!--Identifiers-->
| index2_label = as salt
| CAS_number_Ref = {{cascite|changed|CAS}}
| CAS_number = 119141-88-7
| PubChem = 9579578
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00736
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 7843323
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = N3PA6559FT
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07917
| KEGG2_Ref = {{keggcite|correct|kegg}}
| KEGG2 = D01984
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 50275
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201320

<!--Chemical data-->
| IUPAC_name = (''S'')-(−)-5-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-3''H''-benzoimidazole
 | C=17 | H=19 | N=3 | O=3 | S=1
| smiles = COc1ccc2nc([nH]c2c1)[S@](=O)Cc1ncc(C)c(OC)c1C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SUBDBMMJDZJVOS-XMMPIXPASA-N
}}
<!-- Definition and medical uses -->
'''에스오메프라졸'''(Esomeprazole) 또는 '''에소메프라졸'''은 [[양성자 펌프 억제제]](PPIs)의 일종이다. 2010년 [[아스트라제네카]]가 제조하여 [[다이이찌산쿄]]가 '''넥시엄'''(Nexium)이라는 제품명으로 판매를 시작하였다.<ref>{{보도자료 인용| title=AstraZeneca announces co-promotion agreement with Daiichi Sankyo for NEXIUM in Japan | publisher=AstraZeneca | date=29 October 2010 | url=https://www.astrazeneca.com/media-centre/press-releases/2010/AstraZeneca-announces-copromotion-agreement-with-Daiichi-Sankyo-29102010.html | access-date=15 July 2019}}</ref> [[위산 (소화계)|위산]] 분비를 줄이는 역할을 하므로<ref name=AHFS2019/> [[위식도 역류병]], [[소화성 궤양]], [[졸링거-엘리슨 증후군]] 치료에 쓰인다.<ref name=AHFS2019/><ref name=BNF76>{{서적 인용|title=British national formulary : BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=978-0-85711-338-2 |pages=78|edition=76}}</ref> 다른 PPI와 효과는 유사하다.<ref name=TI2016>{{웹 인용|title=[99] Comparative effectiveness of proton pump inhibitors {{!}} Therapeutics Initiative|url=http://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/|access-date=14 July 2016|date=28 June 2016}}</ref> [[경구 투여|경구]]나 [[정맥 주사]]로 투여한다.<ref name=AHFS2019/>

<!-- Side effects and mechanisms -->
흔한 부작용에는 [[두통]], [[변비]], [[구강건조증]], [[복통]]이 있다.<ref name=AHFS2019/> 심한 부작용에는 [[혈관부종]], [[디피실리균 감염증]], [[폐렴]] 등이 있다.<ref name=AHFS2019/> [[임신]] 중 사용은 안전한 것으로 여겨지나, [[모유 수유|수유]] 중 사용의 안전성은 불명확하다.<ref name=Preg2019>{{웹 인용|title=Esomeprazole Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/esomeprazole.html |website=Drugs.com |access-date=3 March 2019 }}</ref> 에소메프라졸은 [[오메프라졸]]의 (''S'')-(−)-[[광학 이성질체]]이다.<ref name=AHFS2019/>{{efn|따라서 이 이름은 "es + 오메프라졸"로 읽을 수 있다.}} [[위 (해부학)|위]]에 존재하는 [[벽세포]]의 [[수소-칼륨 ATP가수분해효소]]를 차단해 작용한다.<ref name=AHFS2019>{{웹 인용|title=Esomeprazole Magnesium Monograph for Professionals |url=https://www.drugs.com/monograph/esomeprazole-magnesium.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=3 March 2019 }}</ref>

<!-- Society and culture -->
특허가 출원된 것은 1993년, 의학용 사용이 승인된 것은 2000년이다.<ref>{{서적 인용| vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=978-3-527-60749-5 |page=445 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA445 }}</ref> [[복제약]]으로 이용 가능하며 여러 국가에서 [[일반의약품]]으로 구매 가능하다.<ref>{{서적 인용| vauthors = ((Jones & Bartlett Learning)) |title=2018 Nurse's Drug Handbook |date=2017 |publisher=Jones & Bartlett Learning |isbn=978-1-284-12134-6 |page=394 |url=https://books.google.com/books?id=rD1DDwAAQBAJ&pg=PA394 }}</ref><ref name=BNF76/> 2021년 기준으로 한 해 동안 미국에서 400만 건 이상 처방되어, 125번째로 많이 처방된 약물로 기록되었다.<ref>{{웹 인용| title=The Top 300 of 2021 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=14 January 2024 | archive-date=15 January 2024 | archive-url=https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{웹 인용| title = Esomeprazole - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Esomeprazole | access-date = 14 January 2024}}</ref> 미국,<ref name="USA2020OTC">{{웹 인용|url=https://medlineplus.gov/druginfo/meds/a699054.html |website=[[MedlinePlus]] |publisher=[[United States National Library of Medicine]] |access-date=2 March 2020 |title=Esomeprazole}}</ref> 영국,<ref>{{웹 인용| url=https://www.nhs.uk/medicines/esomeprazole/about-esomeprazole/ | title=About esomeprazole | date=13 January 2022 }}</ref> 호주, 캐나다, 뉴질랜드<ref>{{웹 인용| url=
https://www.tga.gov.au/resources/publication/scheduling-decisions-interim/scheduling-delegates-interim-decisions-and-invitation-further-comment-accsacms-march-and-july-2017/14-esomeprazole/ | title=Australian TGA Scheduling of Esomeprazole | date=15 September 2017 | access-date=1 August 2023 }}</ref> 등에서 저용량 제제는 일반의약품으로 처방 없이 구매 가능하다.

== 각주 ==
{{각주}}
{{notelist|1}}

== 외부 링크 ==
* {{웹 인용| url = https://druginfo.nlm.nih.gov/drugportal/name/esomeprazole | publisher = U.S. National Library of Medicine| work = Drug Information Portal| title = Esomeprazole }}
* {{웹 인용| url = https://druginfo.nlm.nih.gov/drugportal/name/esomeprazole%20sodium | publisher = U.S. National Library of Medicine| work = Drug Information Portal| title = Esomeprazole sodium }}

[[분류:아스트라제네카의 제품]]
[[분류:화이자의 제품]]
[[분류:벤즈이미다졸]]
[[분류:페놀 에터]]
[[분류:피리딘]]
[[분류:설폭사이드]]
[[분류:양성자 펌프 억제제]]