{{위키데이터 속성 추적}}
[[파일:Propranolol-2D-skeletal.png|250px|섬네일|대표적인 베타 차단제인 [[프로프라놀롤]] 분자 구조도.]]
'''베타 차단제'''({{llang|en|beta blocker, β-blocker}})는 [[교감 신경]]의 [[아드레날린작동성 수용체]] 중 β-수용체만을 특이하게 차단하는 약제를 가리킨다. '''베타 억제제''', '''베타 블로커'''라고도 불린다. 임상적으로 [[부정맥]]을 컨트롤하거나 2차적 [[심근경색]]을 예방하기 위해 사용된다. 보통 1차적으로는 쓰이지 않으나 [[고혈압]] 완화를 위해 사용되는 경우도 있다.

== 효과 ==
베타 차단제의 [[적응증]]은 다음과 같다.

* [[협심증]]<ref name="betablockerangina1">{{서적 인용|url=https://books.google.com/books?id=ZwL2JXsXSH4C&q=beta+blocker+angina+pectoris|제목=Beta-blockers in hypertension and angina pectoris: different compounds, different strategies|성=Cleophas|이름=Ton|연도=1995|출판사=Kluwer Academic Publishers|isbn=978-0-7923-3516-0}}</ref><ref name="betablockerangina2">{{서적 인용|url=https://books.google.com/books?id=BZjkTZZx4Z8C&q=beta+blocker+angina+pectoris&pg=PA16|제목=Cardia Drug Therapy|성=Khan|이름=M.I. Gabriel|연도=2007|출판사=Humana Press|isbn=978-1-59745-238-0}}</ref><ref name=":0">{{서적 인용|제목=Basic & Clinical Pharmacology|성=Katzung|이름=Bertram|연도=2018|출판사=McGraw-Hill|isbn=9781259641152}}</ref> ([[변이형 협심증]]에 금기)
* [[심방세동]]<ref name="pmid19020848">{{저널 인용|제목=[Treatment of atrial fibrillation in {{sic|every days}} practice]|저널=Der Internist|날짜=December 2008|권=49|호=12|쪽=1437–42, 1444–45|번역제목=Treatment of atrial fibrillation in everyday practice|doi=10.1007/s00108-008-2152-6|pmid=19020848}}</ref>
* [[부정맥|심장 부정맥]]<ref>{{웹 인용|url=https://www.heart.org/en/health-topics/arrhythmia/prevention--treatment-of-arrhythmia/medications-for-arrhythmia|제목=Medications for Arrhythmia|웹사이트=www.heart.org|언어=en|확인날짜=2019-08-10}}</ref><ref name=":0" />
* [[심부전|울혈성 심부전]]<ref>{{웹 인용|url=https://www.acc.org/tools-and-practice-support/clinical-toolkits/heart-failure-practice-solutions/beta-blocker-therapy|제목=Beta Blocker Therapy|웹사이트=American College of Cardiology|확인날짜=2019-08-10|archive-date=2019-08-10|archive-url=https://web.archive.org/web/20190810002245/https://www.acc.org/tools-and-practice-support/clinical-toolkits/heart-failure-practice-solutions/beta-blocker-therapy|url-status=}}</ref>
* [[본태성진전]]<ref>{{웹 인용|url=https://my.clevelandclinic.org/health/drugs/11895-drug-treatments-for-essential-tremor|제목=Essential Tremor Medications|웹사이트=Cleveland Clinic|언어=en|확인날짜=2019-08-10}}</ref>
* [[녹내장]]<ref name=":0" /><ref name=":1">{{서적 인용|제목=Goodman & Gilman's: The Pharmacological Basic of Therapeutics|연도=2018|출판사=McGraw-Hill|isbn=9781259584732}}</ref> - 안약으로 사용하며, [[방수]] 분비를 낮추어 [[안압]]을 낮추는 효과를 보인다.<ref name="pharmnemonics">{{서적 인용|제목=Illustrated Pharmacology Memory Cards: PharMnemonics|성=Shen, Howard|연도=2008|출판사=Minireview|쪽=15|isbn=978-1-59541-101-3}}</ref> )
* [[고혈압]]<ref name=":0" /> - 일반적으로 초기 치료로 선호되지는 않는다.<ref>NICE [https://www.nice.org.uk/guidance/cg127/chapter/1-guidance Hypertension guidance] {{웹아카이브|url=https://web.archive.org/web/20170409111336/https://www.nice.org.uk/guidance/cg127/chapter/1-Guidance|date=April 9, 2017}} Last updated 2013</ref>
* [[갑상샘 기능 항진증]]<ref name=":0" />
* [[편두통]]의 [[예방의학|예방]]<ref>{{웹 인용|url=https://www.uptodate.com/contents/preventive-treatment-of-migraine-in-adults|제목=Preventive Treatment of Migraine in Adults|웹사이트=www.uptodate.com|확인날짜=2019-08-10|archive-date=2019-08-10|archive-url=https://web.archive.org/web/20190810002418/https://www.uptodate.com/contents/preventive-treatment-of-migraine-in-adults|url-status=}}</ref>
* [[승모판 탈출증]]<ref>{{웹 인용|url=https://www.mayoclinic.org/diseases-conditions/mitral-valve-prolapse/diagnosis-treatment/drc-20355452|제목=Mitral Valve Prolapse|날짜=March 6, 2018|웹사이트=Mayo Clinic|확인날짜=August 9, 2019}}</ref>
* [[심근 경색|심근경색]]<ref>{{웹 인용|url=https://www.uptodate.com/contents/acute-myocardial-infarction-role-of-beta-blocker-therapy|제목=Acute myocardial infarction: Role of beta blocker therapy|웹사이트=www.uptodate.com|확인날짜=2019-08-10}}</ref>
* [[크롬친화세포종]]에서 [[알파 차단제]]와 함께 투여<ref>{{웹 인용|url=https://emedicine.medscape.com/article/124059-medication|제목=Pheochromocytoma Medication: Alpha Blockers, Antihypertensives, BPH, Alpha Blocker, Vasodilators, Beta Blockers, Nonselective, Beta Blockers, Beta1 Selective, Antihypertensives, Other, Radiopharmaceuticals|웹사이트=emedicine.medscape.com|확인날짜=2019-08-10}}</ref>
* [[기립성 빈맥 증후군]]<ref name="ww2.mc.vanderbilt.edu">{{웹 인용|url=https://ww2.mc.vanderbilt.edu/adc/38888|제목=Vanderbilt Autonomic Dysfunction Center – Propranolol (Beta Blocker)|웹사이트=ww2.mc.vanderbilt.edu – Vanderbilt Health Institute|위치=Nashville, TN|보존url=https://web.archive.org/web/20190810000350/https://ww2.mc.vanderbilt.edu/adc/38888|보존날짜=August 10, 2019|url-status=dead|확인날짜=2019-08-10}}</ref>
* [[불안]] 및 [[갑상샘 기능 항진증|갑상선 기능 항진증]]의 증상 조절([[빠른맥|빈맥]], [[미진 (의학)|떨림]])<ref name="ww2.mc.vanderbilt.edu" />
* [[테오필린]] 과다 복용<ref>{{웹 인용|url=https://www.uptodate.com/contents/theophylline-poisoning|제목=Theophylline Poisoning|웹사이트=www.uptodate.com|확인날짜=2019-08-10}}</ref>

== 종류 ==

=== 비선택적 제제 ===

* [[프로프라놀롤]]<ref name="PharmLetter BB Table">{{웹 인용|url=https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Dec/Comparison-of-Oral-Beta-Blockers-5052|제목=Comparison of Oral Beta-Blockers|웹사이트=pharmacist.therapeuticresearch.com|출판사=Therapeutic Research Center|보존url=https://web.archive.org/web/20171018134059/https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Dec/Comparison-of-Oral-Beta-Blockers-5052|보존날짜=October 18, 2017|url-status=live|확인날짜=30 April 2017}}</ref>
* [[카르테올롤]]<ref>{{웹 인용|url=https://pubchem.ncbi.nlm.nih.gov/compound/carteolol|제목=CARTEOLOL|웹사이트=pubchem.ncbi.nlm.nih.gov|출판사=U.S. National Library of Medicine|언어=en|보존url=https://web.archive.org/web/20171018134213/https://pubchem.ncbi.nlm.nih.gov/compound/carteolol|보존날짜=October 18, 2017|url-status=live|확인날짜=18 October 2017}}</ref>
* 카르벨딜롤 (추가 α <sub>1</sub> -차단 활성 있음)<ref name="PharmLetter BB Table" />
* [[라베탈롤]] (내재적 교감신경흥분 활성 및 추가적인 α <sub>1</sub> 차단 활성이 있음)<ref name="PharmLetter BB Table" />
* [[나도롤|나돌롤]]<ref name="PharmLetter BB Table" />
* [[펜부톨롤]] (내재적 교감신경흥분 활성이 있음)<ref name="PharmLetter BB Table" />
* [[티모롤|티몰롤]]<ref name="PharmLetter BB Table" />

=== β<sub>1</sub> - 선택적 제제 ===

* [[아세부톨롤]] (내재적 교감신경흥분 활성, ISA 있음)<ref name="PharmLetter BB Table2">{{웹 인용|url=https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Dec/Comparison-of-Oral-Beta-Blockers-5052|제목=Comparison of Oral Beta-Blockers|웹사이트=pharmacist.therapeuticresearch.com|출판사=Therapeutic Research Center|보존url=https://web.archive.org/web/20171018134059/https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Dec/Comparison-of-Oral-Beta-Blockers-5052|보존날짜=October 18, 2017|url-status=live|확인날짜=30 April 2017}}</ref>
* [[아테놀올|아테놀롤]]<ref name="PharmLetter BB Table2" />
* [[베타솔롤]]<ref name="PharmLetter BB Table2" />
* [[비소프롤롤]]<ref name="PharmLetter BB Table2" />
* [[셀리프롤롤]] (내재적 교감신경흥분 활성이 있음)<ref name="Celiprolol">{{웹 인용|url=https://pubchem.ncbi.nlm.nih.gov/compound/2663|제목=Celiprolol|웹사이트=pubchem.ncbi.nlm.nih.gov|출판사=U.S. National Library of Medicine|언어=en|보존url=https://web.archive.org/web/20171018133611/https://pubchem.ncbi.nlm.nih.gov/compound/2663|보존날짜=October 18, 2017|url-status=live|확인날짜=18 October 2017}}</ref>
* [[메토프로롤|메토프롤롤]]<ref name="PharmLetter BB Table2" />
* [[네비볼롤]]<ref name="PharmLetter BB Table2" />
* [[에스모롤|에스몰롤]]<ref name="VolzZang">{{저널 인용|제목=Esmolol, an ultrashort-acting, selective beta 1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties|저널=European Journal of Clinical Pharmacology|연도=1994|권=46|호=5|쪽=399–404|doi=10.1007/BF00191900|pmid=7957532}}</ref>

=== β<sub>2</sub> - 선택적 제제 ===

* [[부탁사민]]<ref>{{웹 인용|url=https://pubchem.ncbi.nlm.nih.gov/compound/18026|제목=Butaxamine|웹사이트=pubchem.ncbi.nlm.nih.gov|출판사=U.S. National Library of Medicine|언어=en|보존url=https://web.archive.org/web/20171018134215/https://pubchem.ncbi.nlm.nih.gov/compound/18026|보존날짜=October 18, 2017|url-status=live|확인날짜=18 October 2017}}</ref>
* [[ICI-118,551]]<ref>{{웹 인용|url=https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A73289|제목=ICI 118551|웹사이트=ChEBI|언어=en}}</ref>

== 같이 보기 ==
* [[MAO 억제제]]
== 각주 ==
{{각주}}
{{전거 통제}}

[[분류:약학]]
[[분류:베타 차단제]]