{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 408580634
| drug_name = 
| IUPAC_name = Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
| image = Loratadine.svg
| image2 = Loratadine - 3d, portrait orientation.png
<!--Clinical data-->
| tradename = Claritin, Claratyne, others
| Drugs.com = {{drugs.com|monograph|loratadine}}
| MedlinePlus = a697038
| pregnancy_AU = B1
| pregnancy_US = B
| legal_UK = GSL
| legal_US = OTC
| legal_CA = OTC
| routes_of_administration = by mouth
<!--Pharmacokinetic data-->
| bioavailability = almost 100%
| protein_bound = 97–99%
| metabolism = [[간]] ([[:en:CYP2D6]]- and [[:en:CYP3A4|3A4]]-mediated)
| elimination_half-life = 8 hours, active metabolite [[:en:desloratadine]] 27 hours
| excretion = 40% as conjugated metabolites into urine<br />Similar amount into the feces
<!--Identifiers-->
| IUPHAR_ligand = 7216
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 79794-75-5
| ATC_prefix = R06
| ATC_suffix = AX13
| PubChem = 3957
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00455
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3820
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 7AJO3BO7QN
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00364
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 998
<!--Chemical data-->
| C=22 | H=23 | Cl=1 | N=2 | O=2
| molecular_weight = 382.88 g/mol
| smiles = O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JCCNYMKQOSZNPW-UHFFFAOYSA-N
}}

'''로라타딘'''({{lang|en|loratadine}}, 상표명: '''Claritin''' 등)은 [[알레르기]] 치료에 사용되는 약물이다.<ref name=AHFS2016/> 여기에는 [[알레르기 비염]], [[두드러기]]가 포함된다.<ref name=AHFS2016/> [[충혈 완화제]] [[슈도에페드린]]와 복합된 [[로라타딘/슈도에페드린]]으로 사용할 수도 있다.<ref name=AHFS2016/> 구강으로 섭취된다.<ref name=AHFS2016>{{웹 인용|title=Loratadine|url=https://www.drugs.com/monograph/loratadine.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221001703/https://www.drugs.com/monograph/loratadine.html|archivedate=21 December 2016|df=}}</ref>

일반적인 부작용으로는 [[졸림]], 구강 건조, 두통이 포함된다.<ref name=AHFS2016/> 심각한 부작용은 드문 편이며 [[알레르기]], [[뇌전증 발작]], [[간질환]]이 포함된다.<ref name=ERC2015/> [[임신]] 중에 사용하는 것은 안전한 것으로 간주되지만 폭넓게 연구되지는 않았다.<ref>{{웹 인용|title=Loratadine Use During Pregnancy {{!}} Drugs.com|url=https://www.drugs.com/pregnancy/loratadine.html|website=www.drugs.com|accessdate=13 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221001209/https://www.drugs.com/pregnancy/loratadine.html|archivedate=21 December 2016|df=}}</ref> 2살 미만의 어린이에게는 권장되지 않는다.<ref name=ERC2015>{{웹 인용|title=Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/29550|date=7 October 2015|website=www.medicines.org.uk|accessdate=13 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161220173725/https://www.medicines.org.uk/emc/medicine/29550|archivedate=20 December 2016|df=}}</ref> [[H1 수용체 대항제]] 계열의 약물에 속한다.<ref name=AHFS2016/>

로라타딘은 1981년 발견되었으며 1993년 상용화되었다.<ref>{{서적 인용|last1=Corey|first1=E.J.|title=Molecules and Medicine|date=2012|publisher=John Wiley & Sons|isbn=9781118361733|chapter-url=https://books.google.ca/books?id=jz2GN6DYoOoC&lpg=RA1-PT108&pg=RA1-PT41|chapter=Loratadine|url-status=live|archiveurl=https://web.archive.org/web/20151222093559/https://books.google.ca/books?id=jz2GN6DYoOoC&lpg=RA1-PT108&pg=RA1-PT41|archivedate=2015-12-22|df=}}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}}</ref> 로라타딘은 [[제네릭 의약품]]으로 구매할 수 있다.<ref name=AHFS2016/> [[개발도상국]]의 도매가는 2015년 기준으로 한 도스 당 대략 US$0.01 ~ 0.06에 달한다.<ref name=ERC2014>{{웹 인용|title=Loratadine|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=925&searchYear=2015|website=International Drug Price Indicator Guide|accessdate=1 June 2018|보존url=https://web.archive.org/web/20180801190537/http://mshpriceguide.org/en/single-drug-information/?DMFId=925&searchYear=2015|보존날짜=2018-08-01|url-status=dead}}</ref> [[미국]] 내에서는 [[일반의약품]]으로 판매된다.<ref name=AHFS2016/>

== 역사 ==
[[셰링 플라우]]가 로라타딘을 개발했다.

== 각주 ==
{{각주}}

== 외부 링크 ==
* [https://www.nlm.nih.gov/medlineplus/druginfo/meds/a697038.html Loratadine]—MedlinePlus Drug Information, U.S. National Library of Medicine, National Institutes of Health
* [https://web.archive.org/web/20070625170636/http://www.rxlist.com/cgi/generic/lorat.htm Claritin (loratadine) drug description]—RxList (Internet Drug Index)
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Loratadine U.S. National Library of Medicine: Drug Information Portal – Loratadine]

[[분류:H1 수용체 대항제]]
[[분류:카밤산염]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:클로로아렌]]
[[분류:화이자의 제품]]
[[분류:바이엘의 제품]]