{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 
| IUPAC_name = [(8''R'',9''S'',13''S'',14''S'',17''S'')-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthren-17-yl] heptanoate
| image = Estradiol enanthate.png
| width = 250px
| image2 = Estradiol enanthate molecule ball.png
| width2 = 250px

<!--Clinical data-->
| tradename = Perlutal, Topasel, Unalmes, Yectames, others
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status = Rx-only
| routes_of_administration = [[Intramuscular injection]]<ref name="pmid8910663" /><ref name="pmid12290848">{{저널 인용| vauthors = Newton JR, D'arcangues C, Hall PE | title = A review of "once-a-month" combined injectable contraceptives | journal = J Obstet Gynaecol (Lahore) | volume = 4 Suppl 1 | pages = S1–34 | year = 1994 | pmid = 12290848 | doi = 10.3109/01443619409027641 }}</ref>
| class = [[Estrogen (medication)|Estrogen]]; [[Estrogen ester]]

<!--Pharmacokinetic data-->
| bioavailability = {{abbr|IM|Intramuscular injection}}: High
| protein_bound = Estradiol: ~98% (to [[human serum albumin|albumin]] and {{abbrlink|SHBG|sex hormone-binding globulin}})<ref name="pmid23375353">{{저널 인용|last1=Stanczyk|first1=Frank Z.|last2=Archer|first2=David F.|last3=Bhavnani|first3=Bhagu R.|title=Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment|journal=Contraception|volume=87|issue=6|year=2013|pages=706–727|issn=0010-7824|doi=10.1016/j.contraception.2012.12.011|pmid=23375353}}</ref><ref name="FalconeHurd2007">{{서적 인용|author1=Tommaso Falcone|author2=William W. Hurd|title=Clinical Reproductive Medicine and Surgery|url=https://books.google.com/books?id=fOPtaEIKvcIC&pg=PA22|year=2007|publisher=Elsevier Health Sciences|isbn=978-0-323-03309-1|pages=22,362,388}}</ref>
| metabolism = [[Bond cleavage|Cleavage]] via [[esterase]]s in the [[liver]], [[blood]], and [[tissue (biology)|tissues]]<ref name="OettelSchillinger2012">{{서적 인용|author1=Michael Oettel|author2=Ekkehard Schillinger|title=Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen|url=https://books.google.com/books?id=wBvyCAAAQBAJ&pg=PA261|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-60107-1|pages=261, 271|quote=Natural estrogens considered here include: [...] Esters of 17β-estradiol, such as estradiol valerate, estradiol benzoate and estradiol cypionate. Esterification aims at either better absorption after oral administration or a sustained release from the depot after intramuscular administration. During absorption, the esters are cleaved by endogenous esterases and the pharmacologically active 17β-estradiol is released; therefore, the esters are considered as natural estrogens. [...] Wiemeyer et al. (1986) measured elevated estradiol levels up to 31 days after an intramuscular dose of 10mg estradiol enanthate.}}</ref><ref name="pmid16112947">{{저널 인용| vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric | volume = 8 Suppl 1 | pages = 3–63 | year = 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 | url = http://hormonebalance.org/images/documents/Kuhl%2005%20%20Pharm%20Estro%20Progest%20Climacteric_1313155660.pdf}}</ref>
| metabolites = [[Estradiol (medication)|Estradiol]], [[heptanoic acid]], and [[metabolite]]s of estradiol<ref name="OettelSchillinger2012" /><ref name="pmid16112947" />
| elimination_half-life = {{abbr|IM|Intramuscular injection}}: 5.6–7.5&nbsp;days<ref name="pmid3814225">{{저널 인용| vauthors = Wiemeyer JC, Fernandez M, Moguilevsky JA, Sagasta CL | title = Pharmacokinetic studies of estradiol enanthate in menopausic women | journal = Arzneimittelforschung | volume = 36 | issue = 11 | pages = 1674–7 | year = 1986 | pmid = 3814225 }}</ref><ref name="pmid8910663" /><ref name="pmid8013220">{{저널 인용| vauthors = Sang GW | title = Pharmacodynamic effects of once-a-month combined injectable contraceptives | journal = Contraception | volume = 49 | issue = 4 | pages = 361–85 | date = April 1994 | pmid = 8013220 | doi = 10.1016/0010-7824(94)90033-7 }}</ref><ref name="ConsultaRemédios">{{웹 인용| url = https://consultaremedios.com.br/algestona-acetofenida-enantato-de-estradiol/bula | archive-url = https://web.archive.org/web/20180918105310/https://consultaremedios.com.br/algestona-acetofenida-enantato-de-estradiol/bula | archive-date = 2018-09-18 | title = Bula do Algestona Acetofenida + Enantato de Estradiol | website = Consulta Remédios | access-date = 2018-09-18 }}</ref>
| duration_of_action = {{abbr|IM|Intramuscular injection}} (10 mg): ~20–30 days<ref name="pmid8013219" /><ref name="OettelSchillinger2012" />
| excretion = [[Urine]]<ref name="pmid8910663" />

<!-- Identifiers -->
| CAS_number_Ref = 
| CAS_number = 4956-37-0
| CAS_supplemental = 
| ATC_prefix = G03
| ATC_suffix = CA03
| ATC_supplemental = 
| PubChem = 21070
| IUPHAR_ligand = 
| DrugBank_Ref = 
| DrugBank = 
| ChemSpiderID_Ref = 
| ChemSpiderID = 19815
| UNII = PAP315WZIA
| KEGG = D04064
| ChEBI = 
| ChEMBL = 1697792
| synonyms = EE; E2E; E2-EN; EEn; Estradiol enanthate; Estradiol heptanoate; SQ-16150

<!--Chemical data-->
| C=25 | H=36 | O=3
| SMILES = CCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C3C=CC(=C4)O)C
| StdInChI_Ref = 
| StdInChI = 1S/C25H36O3/c1-3-4-5-6-7-24(27)28-23-13-12-22-21-10-8-17-16-18(26)9-11-19(17)20(21)14-15-25(22,23)2/h9,11,16,20-23,26H,3-8,10,12-15H2,1-2H3/t20-,21-,22+,23+,25+/m1/s1
| StdInChIKey_Ref = 
| StdInChIKey = RFWTZQAOOLFXAY-BZDYCCQFSA-N
}}
'''에스트라디올 에난테이트'''(Estradiol enantate, E2-En 또는 EEn)는 여성의 호르몬적 산아 제한에 사용되는  [[에스트로겐]] 약물이다.<ref name="pmid8910663">{{저널 인용| vauthors = Jarquín González JD, Elda de Aguirre L, Rodríguez C, Abrego de Aguilar M, Carrillo F, León DA, Lima M, Trigueros S, Acosta R | title = Dihydroxyprogesterone acetophenide 150 mg + estradiol enantate 10 mg as monthly injectable contraceptives | journal = Adv Contracept | volume = 12 | issue = 3 | pages = 213–25 | date = September 1996 | pmid = 8910663 | doi = 10.1007/BF01849664   | s2cid = 2522426 }}</ref><ref name="pmid12290848" /><ref name="BagadePawar2014">{{저널 인용| vauthors = Bagade O, Pawar V, Patel R, Patel B, Awasarkar V, Diwate S | title = Increasing use of long-acting reversible contraception: safe, reliable, and cost-effective birth control | journal = World J Pharm Pharm Sci | volume = 3 | issue = 10 | pages = 364–392 | year = 2014 | issn = 2278-4357 | url = http://www.wjpps.com/download/article/1412071798.pdf}}</ref> DHPA와 함께 복합해서 사용하는 경우 한 달에 한 차례씩 근육 주사를 통해 투여되게 된다.<ref name="pmid8910663" /><ref name="pmid12290848" />

== 각주 ==
{{각주}}

[[분류:에스트란]]
[[분류:페놀류]]
[[분류:전구약물]]
[[분류:동물 약]]
[[분류:합성 에스트로겐]]