{{위키데이터 속성 추적}}
{{유전자 정보}}
'''아연집게 E-box-결합 호메오박스2 (Zinc finger E-box-binding homeobox 2)'''는 [[단백질]]로 사람에서 ''ZEB2''[[유전자]]가 암호화 하고 있다.<ref name="entrez">{{웹 인용| title = Entrez Gene: ZEB2 zinc finger E-box binding homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9839| accessdate = }}</ref>

== 기능 ==
SMADIP1유전자는 delta-EF1(TCF8)/Zfh1과의 하나로, 팔이 두 개인 [[아연집게]]/호메오도메인 단백질이다. SMADIP1은 수용체매개, 수용체활성 SMAD단백질과 함께 상호작용한다.<ref name="entrez"/>

== 임상적 중요성 ==
ZEB2유전자의 변형은 Mowat-Wilson syndrome에 연관되어있다.

== 각주 ==
{{각주}}

== 더 읽어보기 ==
{{참고 자료 시작}}
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* {{저널 인용| author=Verschueren K |title=SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20489–98 |year= 1999 |pmid= 10400677 |doi=10.1074/jbc.274.29.20489  | author2=Remacle JE  | author3=Collart C  | display-authors=3  | last4=Kraft  | first4=H  | last5=Baker  | first5=BS  | last6=Tylzanowski  | first6=P  | last7=Nelles  | first7=L  | last8=Wuytens  | first8=G  | last9=Su  | first9=MT  }}
* {{저널 인용| author=Wakamatsu N |title=Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease |journal=Nat. Genet. |volume=27 |issue= 4 |pages= 369–70 |year= 2001 |pmid= 11279515 |doi= 10.1038/86860  | author2=Yamada Y  | author3=Yamada K  | display-authors=3  | last4=Ono  | first4=Takao  | last5=Nomura  | first5=Noriko  | last6=Taniguchi  | first6=Hiroko  | last7=Kitoh  | first7=Hiroshi  | last8=Mutoh  | first8=Norihiro  | last9=Yamanaka  | first9=Tsutomu }}
* {{저널 인용| author=Comijn J |title=The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion |journal=Mol. Cell |volume=7 |issue= 6 |pages= 1267–78 |year= 2001 |pmid= 11430829 |doi=10.1016/S1097-2765(01)00260-X  | author2=Berx G  | author3=Vermassen P  | display-authors=3  | last4=Verschueren  | first4=Kristin  | last5=Van Grunsven  | first5=Leo  | last6=Bruyneel  | first6=Erik  | last7=Mareel  | first7=Marc  | last8=Huylebroeck  | first8=Danny  | last9=Van Roy  | first9=Frans  }}
* {{저널 인용| author=Cacheux V |title=Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease |journal=Hum. Mol. Genet. |volume=10 |issue= 14 |pages= 1503–10 |year= 2001 |pmid= 11448942 |doi=10.1093/hmg/10.14.1503  | author2=Dastot-Le Moal F  | author3=Kääriäinen H  | display-authors=3  | last4=Bondurand  | first4=N  | last5=Rintala  | first5=R  | last6=Boissier  | first6=B  | last7=Wilson  | first7=M  | last8=Mowat  | first8=D  | last9=Goossens  | first9=M  }}
* {{저널 인용| author1=Tylzanowski P| author2=Verschueren K| author3=Huylebroeck D| author4=Luyten FP |title=Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40001–7 |year= 2001 |pmid= 11477103 |doi= 10.1074/jbc.M104112200 }}
* {{저널 인용| author=Yamada K |title=Nonsense and Frameshift Mutations in ZFHX1B, Encoding Smad-Interacting Protein 1, Cause a Complex Developmental Disorder with a Great Variety of Clinical Features |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1178–85 |year= 2002 |pmid= 11592033 |doi=10.1086/324343  | pmc=1235530  | author2=Yamada Y  | author3=Nomura N  | display-authors=3  | last4=Miura  | first4=Kiyokuni  | last5=Wakako  | first5=Rie  | last6=Hayakawa  | first6=Chiemi  | last7=Matsumoto  | first7=Akiko  | last8=Kumagai  | first8=Toshiyuki  | last9=Yoshimura  | first9=Ikuko  }}
* {{저널 인용| author=Amiel J |title=Large-Scale Deletions and SMADIP1 Truncating Mutations in Syndromic Hirschsprung Disease with Involvement of Midline Structures |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1370–7 |year= 2002 |pmid= 11595972 |doi=10.1086/324342  | pmc=1235547  | author2=Espinosa-Parrilla Y  | author3=Steffann J  | display-authors=3  | last4=Gosset  | first4=Philippe  | last5=Pelet  | first5=Anna  | last6=Prieur  | first6=Marguerite  | last7=Boute  | first7=Odile  | last8=Choiset  | first8=Agnès  | last9=Lacombe  | first9=Didier  }}
* {{저널 인용| author=Zweier C |title="Mowat-Wilson" syndrome with and without Hirschsprung disease is a distinct, recognizable multiple congenital anomalies-mental retardation syndrome caused by mutations in the zinc finger homeo box 1B gene |journal=Am. J. Med. Genet. |volume=108 |issue= 3 |pages= 177–81 |year= 2002 |pmid= 11891681 |doi=10.1002/ajmg.10226  | author2=Albrecht B  | author3=Mitulla B  | display-authors=3  | last4=Behrens  | first4=Rolf  | last5=Beese  | first5=Maike  | last6=Gillessen-Kaesbach  | first6=Gabriele  | last7=Rott  | first7=Hans-Dieter  | last8=Rauch  | first8=Anita  }}
* {{저널 인용| author=Nagaya M |title=Clinical features of a form of Hirschsprung's disease caused by a novel genetic abnormality |journal=J. Pediatr. Surg. |volume=37 |issue= 8 |pages= 1117–22 |year= 2002 |pmid= 12149685 |doi=10.1053/jpsu.2002.34455  | author2=Kato J  | author3=Niimi N  | display-authors=3  | last4=Tanaka  | first4=S  | last5=Wakamatsu  | first5=N  }}
* {{저널 인용| author=Guaita S |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209–16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200  | author2=Puig I  | author3=Franci C  | display-authors=3  | last4=Garrido  | first4=M  | last5=Dominguez  | first5=D  | last6=Batlle  | first6=E  | last7=Sancho  | first7=E  | last8=Dedhar  | first8=S  | last9=De Herreros  | first9=AG }}
* {{저널 인용| author=Espinosa-Parrilla Y |title=Expression of the SMADIP1 gene during early human development |journal=Mech. Dev. |volume=114 |issue= 1–2 |pages= 187–91 |year= 2003 |pmid= 12175509 |doi=10.1016/S0925-4773(02)00062-X  | author2=Amiel J  | author3=Augé J  | display-authors=3  | last4=Encha-Razavi  | first4=Férechté  | last5=Munnich  | first5=Arnold  | last6=Lyonnet  | first6=Stanislas |authorlink6=Stanislas Lyonnet | last7=Vekemans  | first7=Michel  | last8=Attié-Bitach  | first8=Tania  }}
* {{저널 인용| author=Yoneda M |title=Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B |journal=Neurology |volume=59 |issue= 10 |pages= 1637–40 |year= 2002 |pmid= 12451214 |doi=  | author2=Fujita T  | author3=Yamada Y  | display-authors=3  | last4=Yamada  | first4=K  | last5=Fujii  | first5=A  | last6=Inagaki  | first6=T  | last7=Nakagawa  | first7=H  | last8=Shimada  | first8=A  | last9=Kishikawa  | first9=M  }}
* {{저널 인용| author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
* {{저널 인용| author=Postigo AA |title=Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway |journal=EMBO J. |volume=22 |issue= 10 |pages= 2443–52 |year= 2003 |pmid= 12743038 |doi= 10.1093/emboj/cdg225  | pmc=155983 }}
* {{저널 인용| author1=Postigo AA| author2=Depp JL| author3=Taylor JJ| author4=Kroll KL |title=Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins |journal=EMBO J. |volume=22 |issue= 10 |pages= 2453–62 |year= 2003 |pmid= 12743039 |doi= 10.1093/emboj/cdg226  | pmc=155984 }}
* {{저널 인용| author=Zweier C |title=Characterisation of deletions of the ZFHX1B region and genotype-phenotype analysis in Mowat-Wilson syndrome |journal=J. Med. Genet. |volume=40 |issue= 8 |pages= 601–5 |year= 2003 |pmid= 12920073 |doi=10.1136/jmg.40.8.601  | pmc=1735564  | author2=Temple IK  | author3=Beemer F  | display-authors=3  | last4=Zackai  | first4=E  | last5=Lerman-Sagie  | first5=T  | last6=Weschke  | first6=B  | last7=Anderson  | first7=CE  | last8=Rauch  | first8=A  }}
{{참고 자료 끝}}

== 외부 링크 ==
* [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=mws GeneReviews/NIH/NCBI/UW entry on Mowat-Wilson syndrome]
* {{MeshName|ZEB2+protein,+human}}

[[분류:생물학]]
[[분류:전사인자]]
[[분류:인간 2번 염색체상 유전자]]