{{위키데이터 속성 추적}}
{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 461101846
| Name = 
| ImageFile = Fluorescein 2.svg 
| ImageAlt = Skeletal formula
| ImageFile1 = Fluorescein-3D-balls.png
| ImageAlt1 = Ball-and-stick model
| ImageFile2 = Fluorescein-sample.jpg
| ImageAlt2 = Sample of dark red powder
| IUPACName = 3′,6′-dihydroxyspiro[isobenzofuran-1(3''H''),9′-[9''H'']xanthen]-3-one
| OtherNames = Fluorescein, resorcinolphthalein, C.I. 45350, solvent yellow 94, D & C yellow no. 7, angiofluor, Japan yellow 201, soap yellow
| SystematicName = 
| pronounce = {{IPAc-en|f|l|ʊəˈr|ɛ|s|i|.|ɪ|n|,_|f|l|ʊəˈr|ɛ|s|iː|n}}
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 15968
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = TPY09G7XIR
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01261
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 177756
| InChI = 1/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
| InChIKey = GNBHRKFJIUUOQI-UHFFFAOYAZ
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GNBHRKFJIUUOQI-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 2321-07-5
| EINECS = 219-031-8
| PubChem = 16850
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00693
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 31624
| SMILES = c1ccc2c(c1)C(=O)OC23c4ccc(cc4Oc5c3ccc(c5)O)O
| MeSHName = Fluorescein
  }}
| Section2 = {{Chembox Properties
| C=20 | H=12 | O=5
| Appearance = 
| Density = 1.602 g/mL
| MeltingPtC = 314 to 316
| BoilingPt = 
| Solubility = Slightly
  }}
| Section3 = 
| Section4 = 
| Section5 = 
| Section6 = {{Chembox Pharmacology
| ATCCode_prefix = S01
| ATCCode_suffix = JA01
}}
| Section7 = {{Chembox Hazards
|   GHSPictograms = {{GHS07}}
|   GHSSignalWord = Warning
|   HPhrases = {{H-phrases|319}}
|   PPhrases = {{P-phrases|305|351|338}}
| MainHazards = 
| FlashPt = 
| AutoignitionPt = 
  }}
}}
'''플루오레세인'''({{lang|en|fluorescein}})은 물과 알코올에 살며시 용해된 짙은 황색/빨간색의 파우더로 이용할 수 있는 합성 [[유기 화합물]]의 하나이다. [[형광]] [[플로 트레이서|트레이서]]로 수많은 분야에 널리 응용된다.

또, 플루오레세인은 460 나노미터의 [[등흡수점]]을 가지고 있다. 플루오레세인은 색상 첨가제로도 알려져 있다. ([[D&C]] 황색 번호 7)

== 합성 ==
플루오레세인은 [[아돌프 폰 바이어]]가 1871년 처음 합성하였다.<ref>Baeyer, Adolf (1871) [https://books.google.com/books?id=UblKBwb6CicC&pg=PA555#v=onepage&q&f=false "Uber ein neue Klasse von Farbstoffen"] (On a new class of dyes), ''Berichte der Deutschen chemischen Gesellschaft zu Berlin'', '''4''' : 555-558 ; see p. 558.</ref> [[프리델-크래프츠 반응]]을 통해 [[염화 아연]]이 있는 데에서 [[프탈산 무수물]]과 [[레조르시놀]]을 가지고 준비할 수 있다.

[[파일:ZnCl2 fluorescein.png|가운데|500px]]
== 용도 == 
흔히 사용되는 노란색 [[형광펜]]의 염료로 사용되며, [[관개]] 시설의 누출 감지, [[생물학]]에서 [[염색]]을 위한 사용, 염료, 각막 결막 염색(이를 통해 [[안구건조증]] [[진단]])에 사용된다.
== 안전 ==
정량 사용 시 큰 문제는 없으나, 과량 투여 시 [[구역질]], [[구토]], [[두드러기]], [[급성]] [[저혈압]], [[과민증]]<ref>{{저널 인용| pmid = 9673591| year = 1998| title = The diagnosis and management of anaphylaxis. Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology| journal = The Journal of allergy and clinical immunology| volume = 101| url = http://www.allergy123.com/library/documents/anaphylaxis.pdf| issue = 6 Pt 2| pages = S465–528| access-date = 2016-07-23| archive-date = 2015-07-24| archive-url = https://web.archive.org/web/20150724105353/http://www.allergy123.com/library/documents/anaphylaxis.pdf| url-status = }}</ref><ref>[http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=6887&nbr=4211 The diagnosis and management of anaphylaxis: an updated practice parameter.] {{웨이백|url=http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=6887&nbr=4211# |date=20070805182556 }} National Guideline Clearinghouse.</ref>, [[심정지]]<ref name="pmid8952662">{{저널 인용 | pmid = 8952662| year = 1996| author1 = El Harrar| first1 = N| title = Anaphylactic shock caused by application of fluorescein on the ocular conjunctiva| journal = Presse medicale (Paris, France : 1983)| volume = 25| issue = 32| pages = 1546–7| last2 = Idali| first2 = B| last3 = Moutaouakkil| first3 = S| last4 = El Belhadji| first4 = M| last5 = Zaghloul| first5 = K| last6 = Amraoui| first6 = A| last7 = Benaguida| first7 = M}}</ref>, 등을 포함한 [[부작용]]을 초래할 수 있으며, 극히 일부에서 과민증으로 인한 돌연사가 보고된 적 있다.<ref name="pmid10356782">{{저널 인용|vauthors=Fineschi V, Monasterolo G, Rosi R, Turillazzi E | title = Fatal anaphylactic shock during a fluorescein angiography| journal = Forensic Sci. Int.| volume = 100| issue = 1–2| pages = 137–42| year = 1999| pmid = 10356782| doi = 10.1016/S0379-0738(98)00205-9 }}</ref><ref name="pmid15296251">{{저널 인용|vauthors=Hitosugi M, Omura K, Yokoyama T, Kawato H, Motozawa Y, Nagai T, Tokudome S | title = An autopsy case of fatal anaphylactic shock following fluorescein angiography: a case report| journal = Med Sci Law| volume = 44| issue = 3| pages = 264–5| year = 2004| pmid = 15296251| doi = 10.1258/rsmmsl.44.3.264| issn = }}</ref>

== 같이 보기 ==
{{위키공용분류}}
* [[에오신]]
* [[머큐로크롬]]
* [[에리트로신]]
* [[메틸렌 블루]]

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{언어링크|en}} [http://omlc.ogi.edu/spectra/PhotochemCAD/html/fluorescein(EtOH).html Absorption and Emission Spectra of Fluorescein in Ethanol] and [http://omlc.ogi.edu/spectra/PhotochemCAD/html/fluorescein-dibase.html Basic Ethanol] at [[OGI School of Science and Engineering]]
* {{언어링크|en}} [https://web.archive.org/web/20060312202803/http://probes.invitrogen.com/handbook/figures/0571.html Fluorescein Ionization Equilibria] at [[Invitrogen]]
* {{언어링크|en}} [http://omlc.ogi.edu/spectra/PhotochemCAD/html/fluorescein-dibase.html Absorption spectra and fluorescence emission spectra]

{{전거 통제}}

[[분류:염색 염료]]
[[분류:페놀류]]
[[분류:벤조산]]