{{위키데이터 속성 추적}}
[[파일:CX-516-2D-skeletal.svg|220px|섬네일|오른쪽|[[CX-516]]은 가장 초기의 암파카인 중 하나이며, 전형적인 암파카인이다.]]

'''암파카인'''({{llang|en|ampakine 또는 AMPAkine}})은 [[벤즈아마이드]] 또는 밀접하게 관련된 [[화학 구조]]를 가진 [[AMPA 수용체 양성 알로스테릭 조절인자]]의 하위 그룹이다.<ref name="pmid22886028">{{저널 인용| vauthors = Froestl W, Muhs A, Pfeifer A | title = Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors | journal = J. Alzheimers Dis. | volume = 32 | issue = 4 | pages = 793–887 | year = 2012 | pmid = 22886028 | doi = 10.3233/JAD-2012-121186 }}</ref><ref name="pmid15180479">{{저널 인용| author = O'Neill, M. J.| author2 = Bleakman, D.| author3 = Zimmerman, D. M.| author4 = Nisenbaum, E. S. | title = AMPA Receptor Potentiators for the Treatment of CNS Disorders | journal = Current Drug Targets. CNS and Neurological Disorders | volume = 3 | issue = 3 | pages = 181–194 | date = 2004 | pmid = 15180479 | doi = 10.2174/1568007043337508 }}</ref> 이들은 '''CX 화합물'''({{llang|en|CX compound}})로도 알려져 있다.<ref name="pmid22886028" /> 암파카인은 [[AMPA 수용체]](AMPAR)에서 이름을 따왔는데, AMPA 수용체는 암파카인이 상호작용하고 [[알로스테릭 조절인자|양성 알로스테릭 조절인자]](PAM)로 작용하는 일종의 [[이온성 글루탐산 수용체]]이다.<ref name="pmid22886028" /> 모든 암파카인은 AMPAR PAM이지만, 모든 AMPAR PAM이 암파카인인 것은 아니다.

== 같이 보기 ==
* [[연구 중인 항우울제 목록]]
* [[AMPA 수용체]]
* [[AMPA]]

== 각주 ==
{{각주|2}}

== 더 읽을거리 ==
* {{저널 인용| author = Staubli, U.| author2 = Rogers, G.| author3 = Lynch, G. | title = Facilitation of glutamate receptors enhances memory | journal = Proc Natl Acad Sci U S A | date = 1994 | volume = 91 | issue = 2 | pages = 777–781 | doi = 10.1073/pnas.91.2.777 | pmid = 8290599 | pmc = 43032 | bibcode = 1994PNAS...91..777S| doi-access = free}}
* {{저널 인용| display-authors = 4| author = Staubli, U.| author2 = Perez, Y.| author3 = Xu, F. B.| author4 = Rogers, G.| author5 = Ingvar, M.| author6 = Stone-Elander, S.| author7 = Lynch, G. | title = Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo | journal = Proc Natl Acad Sci U S A | date = 1994 | volume = 91 | issue = 23 | pages = 11158–11162 | pmid = 7972026 | pmc = 45186 | doi=10.1073/pnas.91.23.11158| bibcode = 1994PNAS...9111158S| doi-access = free}}
* {{저널 인용| author = Arai, A.| author2 = Lynch G. | date = 1992 | title = Factors regulating the magnitude of long-term potention induced by theta pattern stimulation | journal = Brain Research | volume = 598 | issue = 1–2 | pages = 173–184 | doi = 10.1016/0006-8993(92)90181-8 | pmid = 1486479 | s2cid = 9775469 }}
* {{저널 인용| author = Arai, A.| author2 = Silberg, J.| author3 = Kessler, M.| author4 = Lynch, G. | date = 1995 | title = Effect of thiocyanate on AMPA receptor mediated responses in excised patches and hippocampal slices | journal = Neuroscience | volume = 66 | issue = 4 | pages = 815–827 | doi = 10.1016/0306-4522(94)00616-D | pmid = 7544449 | s2cid = 41021252}}
* {{저널 인용| display-authors = 4| author = Suppiramaniam, V.| author2 = Bahr, B. A.| author3 = Sinnarajah, S.| author4 = Owens, K.| author5 = Rogers, G.| author6 = Yilma, S.| author7 = Vodyanoy, V. | date = 2001 | title = Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors | journal = Synapse | volume = 40 | issue = 2 | pages = 154–158 | doi = 10.1002/syn.1037 | pmid = 11252027 | s2cid = 9705232}}
* {{저널 인용| display-authors = 4| author = Porrino, L. J.| author2 = Daunais, J. B.| author3 = Rogers, G. A.| author4 = Hampson, R. E.| author5 = Deadwyler, S. A. | date = 2005 | title = Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates | journal = PLOS Biology | volume = 3 | issue = 9 | pages = e299 | doi = 10.1371/journal.pbio.0030299 | pmid = 16104830 | pmc = 1188239 | doi-access = free}}
* {{저널 인용| author = Bast, T.| author2 = da Silva, B. M.| author3 = Morris, R. G. | title = Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory | journal = Journal of Neuroscience | date = 2005 | volume = 25 | issue = 25 | pages = 5845–5856 | doi = 10.1523/JNEUROSCI.0698-05.2005 | pmid = 15976073 | pmc = 6724786}}

== 외부 링크 ==
* [http://www.neurotransmitter.net/ampakines.html Ampakine Article Abstracts]
* [https://www.newscientist.com/article.ns?id=dn7342 Recent Article About CX717]
* [http://www.alzheimersscreen.com/Ampakines.htm Article on Ampakines with reference to Alzheimers] {{Webarchive|url=https://web.archive.org/web/20150203064925/http://www.alzheimersscreen.com/Ampakines.htm |date=2015-02-03 }}
* [https://patents.google.com/patent/US5650409 US Patent 5,650,409]
* [https://patents.google.com/patent/US6030968 US Patent 6,030,968]
* [https://patents.google.com/patent/US6730677 US Patent 6,730,677]
* [https://patents.google.com/patent/US7307073 US Patent 7,307,073]

[[분류:AMPA 수용체 양성 알로스테릭 조절제]]
[[분류:암파카인| ]]