{{위키데이터 속성 추적}}
{{유전자 정보}}
'''SH2 도메인 함유 어댑터 단백질 B'''(SH2 domain-containing adapter protein B)는 인간에서 ''SHB'' [[유전자]]에 의해 암호화 된 [[단백질]]이다.<ref name="pmid7713524">{{저널 인용|제목=The SHB adaptor protein maps to human chromosome 9|저널=Genomics|날짜=Dec 1994|권=24|호=3|쪽=615–7|doi=10.1006/geno.1994.1681|pmc=|pmid=7713524}}</ref><ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6461|제목=Entrez Gene: SHB Src homology 2 domain containing adaptor protein B|확인날짜=}}</ref>

== 상호 작용 ==
SHB는 다음과 상호 작용하는 것으로 나타났다. {{Div col}}
* [[EPS8]]<ref name = pmid7537362/>
* [[섬유아세포 성장 요소 수용체 1]]<ref name = pmid7537362>{{저널 인용| vauthors = Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M | title = Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins | journal = Oncogene | volume = 10 | issue = 8 | pages = 1475–83 | date = Apr 1995 | pmid = 7537362 | doi =  }}</ref>
* [[활성 T 세포 링커]]<ref name = pmid10488157>{{저널 인용| vauthors = Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M | title = Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 39 | pages = 28050–7 | date = Sep 1999 | pmid = 10488157 | doi =  10.1074/jbc.274.39.28050}}</ref><ref name = pmid12084069>{{저널 인용| vauthors = Lindholm CK, Henriksson ML, Hallberg B, Welsh M | title = Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 13 | pages = 3279–88 | date = Jul 2002 | pmid = 12084069 | doi =  10.1046/j.1432-1033.2002.03008.x}}</ref>
* [[림프구 세포 단백질 2]]<ref name = pmid12084069/>
* [[PIK3R1]]<ref name = pmid7537362/>
* [[Src]]<ref name = pmid7537362/>
* [[VAV1]]<ref name = pmid12084069/>
* [[ZAP-70]]<ref name = pmid12084069/>
{{Div col end}}

== 각주 ==
{{각주}}

== 추가 자료 ==
{{참고 자료 시작|2}}
* {{저널 인용|제목=Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins|저널=Oncogene|날짜=Apr 1995|권=10|호=8|쪽=1475–83|doi=|pmid=7537362}}
* {{저널 인용|제목=Shb is a ubiquitously expressed Src homology 2 protein|저널=Oncogene|날짜=Jan 1994|권=9|호=1|쪽=19–27|doi=|pmid=8302579}}
* {{저널 인용|제목=Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb|저널=Oncogene|날짜=Sep 1996|권=13|호=5|쪽=955–61|doi=|pmid=8806685}}
* {{저널 인용|제목=Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins|저널=Oncogene|날짜=Feb 1998|권=16|호=7|쪽=891–901|doi=10.1038/sj.onc.1201607|pmid=9484780}}
* {{저널 인용|제목=The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells|저널=Cell Growth & Differentiation|날짜=Sep 1998|권=9|호=9|쪽=757–66|doi=|pmid=9751119}}
* {{저널 인용|제목=Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells|저널=The Journal of Biological Chemistry|날짜=Sep 1999|권=274|호=39|쪽=28050–7|doi=10.1074/jbc.274.39.28050|pmid=10488157}}
* {{저널 인용|제목=Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis|저널=Blood|날짜=Jun 2000|권=95|호=11|쪽=3403–11|doi=|pmid=10828022}}
* {{저널 인용|제목=Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization|저널=Experimental Cell Research|날짜=Jun 2000|권=257|호=2|쪽=245–54|doi=10.1006/excr.2000.4896|pmid=10837138}}
* {{저널 인용|제목=NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway|저널=Experimental Cell Research|날짜=Sep 2000|권=259|호=2|쪽=370–7|doi=10.1006/excr.2000.4984|pmid=10964504}}
* {{저널 인용|제목=SH2-Bbeta is a Rac-binding protein that regulates cell motility|저널=The Journal of Biological Chemistry|날짜=Mar 2002|권=277|호=12|쪽=10669–77|doi=10.1074/jbc.M111138200|pmid=11786545}}
* {{저널 인용|제목=Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells|저널=European Journal of Biochemistry / FEBS|날짜=Jul 2002|권=269|호=13|쪽=3279–88|doi=10.1046/j.1432-1033.2002.03008.x|pmid=12084069}}
* {{저널 인용|제목=The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells|저널=Molecular Biology of the Cell|날짜=Aug 2002|권=13|호=8|쪽=2881–93|doi=10.1091/mbc.E02-02-0103|pmc=117949|pmid=12181353}}
* {{저널 인용|제목=IL-2 receptor signaling through the Shb adapter protein in T and NK cells|저널=Biochemical and Biophysical Research Communications|날짜=Aug 2002|권=296|호=4|쪽=929–36|doi=10.1016/S0006-291X(02)02016-8|pmid=12200137}}
* {{저널 인용|제목=The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells|저널=Cellular Signalling|날짜=Feb 2003|권=15|호=2|쪽=171–9|doi=10.1016/S0898-6568(02)00076-1|pmid=12464388}}
* {{저널 인용|제목=Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins|저널=Molecular Medicine|날짜=Nov 2002|권=8|호=11|쪽=695–704|doi=10.1007/BF03402033|pmc=2039954|pmid=12520086}}
* {{저널 인용|제목=The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration|저널=The Journal of Biological Chemistry|날짜=May 2004|권=279|호=21|쪽=22267–75|doi=10.1074/jbc.M312729200|pmid=15026417}}
{{참고 자료 끝}}
[[분류:인간 9번 염색체상 유전자]]