{{위키데이터 속성 추적}}
{{효소 정보
| 이름 = UDP-포도당 6-탈수소효소
| AltNames =
| 그림 = 2qg4.jpg
| 그림_크기 = 270px
| caption = 
| EC_number = 1.1.1.22
| CAS_number = 9028-26-6
| GO_code = 0003979
}}
'''UDP-포도당 6-탈수소효소'''({{llang|en|UDP-glucose 6-dehydrogenase}}) ({{EC number|1.1.1.22}})는 사람에서 ''UGDH'' [[유전자]]에 의해 암호화되는 [[세포질]] [[효소]]이다.<ref name="pmid9737970">{{저널 인용| vauthors = Spicer AP, Kaback LA, Smith TJ, Seldin MF | title = Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25117–24 | date = Sep 1998 | pmid = 9737970 | doi = 10.1074/jbc.273.39.25117 | doi-access = free }}</ref><ref name="pmid10575217">{{저널 인용| vauthors = Marcu O, Stathakis DG, Marsh JL | title = Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 86 | issue = 3–4 | pages = 244–5 | date = Jan 2000 | pmid = 10575217 | doi = 10.1159/000015350 | s2cid = 25740995 }}</ref><ref name="entrez">{{웹 인용| title = Entrez Gene: UGDH UDP-glucose dehydrogenase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7358}}</ref>

이 유전자에 의해 암호화되는 단백질은 [[UDP-포도당]]을 UDP-글루쿠론산으로 전환시키며, [[히알루론산]], [[콘드로이틴 황산]], [[헤파란 황산]]과 같은 [[글리코사미노글리칸]]의 [[생합성]] 과정에 참여한다. 이들 글리코실화된 화합물은 세포 외 기질의 공통적인 구성 성분이며, 신호 전달, 세포 이동, 암 성장, 전이에서 역할을 수행할 수 있다. 이 유전자의 발현은 성장 인자 베타를 변형시킴으로써 상향 조절되고 [[저산소증]]에 의해 하향 조절된다.<ref name="entrez" />

UDP-포도당 6-탈수소효소는 [[오탄당|오탄당과 글루쿠론산 간의 상호전환]] 과정, 아스코르브산 및 알다르산 대사, 녹말 및 수크로스 대사, [[당뉴클레오타이드 대사]]의 4가지 [[대사 경로]]에 참여한다.

UDP-포도당 6-탈수소효소의 결핍은 인간의 간질성 뇌병증과 관련이 있다는 것이 최근에 밝혀졌다.<ref>Hengel, H., Bosso-Lefèvre, C., Grady, G. et al. Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nat Commun 11, 595 (2020). https://doi.org/10.1038/s41467-020-14360-7</ref>

== 생화학 ==
UDP-포도당 6-탈수소효소는 다음과 같은 [[화학 반응]]을 [[촉매]]하는 [[효소]]이다.

:UDP-포도당 + 2 NAD<sup>+</sup> + H<sub>2</sub>O  ⇄  UDP-글루쿠론산 + 2 NADH + 2 H<sup>+</sup>

UDP-포도당 6-탈수소효소의 3가지 [[반응물|기질]]은 [[UDP-포도당]], [[NAD+|NAD<sup>+</sup>]], [[물|H<sub>2</sub>O]]이며, 3가지 [[생성물]]은 [[UDP-글루쿠론산]], [[NADH]], [[수소 이온|H<sup>+</sup>]]이다.<ref name="pmid1091296">{{저널 인용| vauthors = Druzhinina TN, Kusov YY, Shibaev VN, Kochetkov NK, Bielý P, Kucár S, Bauer S | title = Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization | journal = Biochimica et Biophysica Acta | volume = 381 | issue = 2 | pages = 301–7 | date = Feb 1975 | pmid = 1091296 | doi = 10.1016/0304-4165(75)90236-6 }}</ref><ref name="pmid13373402">
{{저널 인용| vauthors = Kalckar HM, Maxwell ES, Strominger JL | title = Some properties of uridine diphosphoglucose dehydrogenase | journal = Archives of Biochemistry and Biophysics | volume = 65 | issue = 1 | pages = 2–10 | date = Nov 1956 | pmid = 13373402 | doi = 10.1016/0003-9861(56)90171-0 }}</ref><ref name="pmid13459898">{{저널 인용| vauthors = Strominger JL, Mapson LW | title = Uridine diphosphoglucose dehydrogenase of pea seedlings | journal = The Biochemical Journal | volume = 66 | issue = 4 | pages = 567–72 | date = Aug 1957 | pmid = 13459898 | pmc = 1200063 | doi=10.1042/bj0660567}}</ref><ref name="pmid13398389">{{저널 인용| vauthors = Axelrod J, Kalckar HM, Maxwell ES, Strominger JL | title = Enzymatic formation of uridine diphosphoglucuronic acid | journal = The Journal of Biological Chemistry | volume = 224 | issue = 1 | pages = 79–90 | date = Jan 1957 | doi = 10.1016/S0021-9258(18)65012-4 | pmid = 13398389 | doi-access = free }}</ref>

UDP-포도당 6-탈수소효소는 [[산화환원효소]] 부류에 속하며, 특히 공여체가 CH-OH기이고 수용체가 NAD<sup>+</sup> 또는 NADP<sup>+</sup>인 효소에 속한다.

== 명명법 ==
UDP-포도당 6-탈수소효소의 계통명은 '''UDP-포도당:NAD<sup>+</sup> 6-산화환원효소'''({{llang|en|UDP-glucose:NAD<sup>+</sup> 6-oxidoreductase}})이다.

다음은 일반적으로 사용되는 다른 이름들이다.
* '''UDP-포도당 탈수소효소'''({{llang|en|UDP-glucose dehydrogenase}})
* '''유리딘 다이포스포글루코스 탈수소효소'''({{llang|en|uridine diphosphoglucose dehydrogenase}})
* '''UDPG 탈수소효소'''({{llang|en|UDPG dehydrogenase}})
* '''UDPG:NAD 산화환원효소'''({{llang|en|UDPG:NAD oxidoreductase}})
* '''UDP-α-D-포도당:NAD 산화환원효소'''({{llang|en|UDP-α-D-glucose:NAD oxidoreductase}})
* '''UDP-포도당:NAD<sup>+</sup> 산화환원효소'''({{llang|en|UDP-glucose:NAD<sup>+</sup> oxidoreductase}})
* '''유리딘 이인사 포도당 탈수소효소'''({{llang|en|uridine diphosphate glucose dehydrogenase}})
* '''UDP-D-포도당 탈수소효소'''({{llang|en|UDP-D-glucose dehydrogenase}})
* '''유리딘 이인산 D-포도당 탈수소효소'''({{llang|en|uridine diphosphate D-glucose dehydrogenase}})

== 같이 보기 ==
* [[UDP-포도당]]
* [[탈수소효소]]
* [[산화환원효소]]

== 각주 ==
{{각주|1}}

== 더 읽을거리 ==
{{참고 자료 시작| 2}}
* {{저널 인용| vauthors = Peng HL, Lou MD, Chang ML, Chang HY | title = cDNA cloning and expression analysis of the human UDPglucose dehydrogenase | journal = Proceedings of the National Science Council, Republic of China. Part B, Life Sciences | volume = 22 | issue = 4 | pages = 166–72 | date = Oct 1998 | pmid = 9850599 }}
* {{저널 인용| vauthors = Bontemps Y, Maquart FX, Wegrowski Y | title = Human UDP-glucose dehydrogenase gene: complete cloning and transcription start mapping | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 3 | pages = 981–5 | date = Sep 2000 | pmid = 10973831 | doi = 10.1006/bbrc.2000.3389 }}
* {{저널 인용| vauthors = Bontemps Y, Vuillermoz B, Antonicelli F, Perreau C, Danan JL, Maquart FX, Wegrowski Y | title = Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia | journal = The Journal of Biological Chemistry | volume = 278 | issue = 24 | pages = 21566–75 | date = Jun 2003 | pmid = 12682078 | doi = 10.1074/jbc.M209366200 | doi-access = free }}
* {{저널 인용| vauthors = Sommer BJ, Barycki JJ, Simpson MA | title = Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations | journal = The Journal of Biological Chemistry | volume = 279 | issue = 22 | pages = 23590–6 | date = May 2004 | pmid = 15044486 | doi = 10.1074/jbc.M401928200 | doi-access = free }}
* {{저널 인용| vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
* {{저널 인용| vauthors = Huh JW, Yoon HY, Lee HJ, Choi WB, Yang SJ, Cho SW | title = Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 36 | pages = 37491–8 | date = Sep 2004 | pmid = 15247292 | doi = 10.1074/jbc.M404234200 | doi-access = free }}
* {{저널 인용| vauthors = Huh JW, Lee HJ, Choi MM, Yang SJ, Yoon SY, Kim DW, Kim SY, Choi SY, Cho SW | title = Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis | journal = Bioconjugate Chemistry | volume = 16 | issue = 3 | pages = 710–6 | year = 2005 | pmid = 15898741 | doi = 10.1021/bc0500387 }}
* {{저널 인용| vauthors = Vatsyayan J, Peng HL, Chang HY | title = Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript | journal = Journal of Biochemistry | volume = 137 | issue = 6 | pages = 703–9 | date = Jun 2005 | pmid = 16002992 | doi = 10.1093/jb/mvi082 }}
* {{저널 인용| vauthors = Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M, Zhou ZM, Sha JH | title = A two-dimensional electrophoresis reference map of human ovary | journal = Journal of Molecular Medicine | volume = 83 | issue = 10 | pages = 812–21 | date = Oct 2005 | pmid = 16021519 | doi = 10.1007/s00109-005-0676-y | s2cid = 6644433 }}
* {{저널 인용| vauthors = Vatsyayan J, Lin CT, Peng HL, Chang HY | title = Identification of a cis-acting element responsible for negative regulation of the human UDP-glucose dehydrogenase gene expression | journal = Bioscience, Biotechnology, and Biochemistry | volume = 70 | issue = 2 | pages = 401–10 | date = Feb 2006 | pmid = 16495656 | doi = 10.1271/bbb.70.401 | s2cid = 25853385 }}
* {{저널 인용| vauthors = Huh JW, Robinson RC, Lee HS, Lee JI, Heo YS, Kim HT, Lee HJ, Cho SW, Choe H | title = Expression, purification, crystallization, and preliminary X-Ray analysis of the human UDP-glucose dehydrogenase | journal = Protein and Peptide Letters | volume = 13 | issue = 8 | pages = 859–62 | year = 2006 | pmid = 17073734 | doi = 10.2174/092986606777841253 | s2cid = 28298102 | url = https://semanticscholar.org/paper/953209ebe79ef8d8af18aa601808a792f5f9f86d }}
* {{저널 인용| vauthors = Easley KE, Sommer BJ, Boanca G, Barycki JJ, Simpson MA | title = Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280 | journal = Biochemistry | volume = 46 | issue = 2 | pages = 369–78 | date = Jan 2007 | pmid = 17209547 | doi = 10.1021/bi061537d }}
{{참고 자료 끝}}

{{효소}}
{{알코올 산화환원효소}}

[[분류:EC 1.1.1]]
[[분류:NADH 의존 효소]]
[[분류:구조가 알려진 효소]]
[[분류:인간 4번 염색체상 유전자]]