{{위키데이터 속성 추적}}
{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 449569282
| Name = 노빌레틴
| ImageFile = Nobiletin.svg
| ImageSize = 240
| ImageAlt = Skeletal formula of nobiletin
| ImageFile1 = Nobiletin molecule ball.png
| ImageSize1 = 240
| ImageAlt1 = Ball-and-stick model of nobiletin
| IUPACName = 3′,4′,5,6,7,8-Hexamethoxyflavone
| PIN = 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4''H''-1-benzopyran-4-one
| OtherNames = Hexamethoxyflavone
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 478-01-3
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = D65ILJ7WLY
| SMILES = c1c(OC)c(OC)ccc1C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 65283
| InChI = 1/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
| InChIKey = MRIAQLRQZPPODS-UHFFFAOYAI
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = MRIAQLRQZPPODS-UHFFFAOYSA-N
| RTECS = 
| MeSHName = 
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 7602
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = C10112
| PubChem = 72344
  }}
|Section2={{Chembox Properties
| C=21 | H=22 | O=8
| Density =
| MeltingPt =
| BoilingPt =
  }}
}}

'''노빌레틴''' (Nobiletin)은 감귤류의 껍질 등에 많이 포함되어 있는 [[유기 화합물]]로, 플라본을 골격으로 하는 폴리메톡시 [[플라보노이드]] ([[O-메틸화 플라보노이드|O-메틸화플라보노이드]])의 일종이다.

== 함유 식품 ==
주로 감귤류에 많이 포함되어 있으며, 특히 [[병감]], 시콰사 등에 많이 포함되어 있다.<ref>{{저널 인용|제목=Flavonoid composition of fruit tissues of citrus species|저널=Biosci Biotechnol Biochem|성=Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H|날짜=2006|권=70|쪽=178-192|doi=10.1271/bbb.70.178|pmid=16428836}}</ref> 과육 부분에는 그다지 포함되어 있지 않고, 과피 부분인 플라베드(외과피), 알베드(중과피)에 특히 많이 함유되어 있다.
{| class="wikitable" style="text-align:center;"
!감귤류
! 과일 전체
! 과육
! 과피
! 플라베도
! 알베도
|-
| 폰칸(병감)
| 30.6
| 0.8
| 110
| 198
| 33.3
|-
| 시콰사
| 30.3
| 2.5
| 85.2
| 122
| 41.0
|-
| 온주밀감
| 1.5
| 0
| 6.4
| 10.8
| 1.8
|}
주:생과의 각 조직 100g당 함유량(mg)

== 약리 작용 ==
[[생체외|in vitro]]나 동물 실험에서 [[항염증제|항염증 작용]]이나 [[종양]]의 침윤, 확산, 전이를 막는 작용,<ref>{{저널 인용|제목=The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice|저널=Jpn J Cancer Res|성=Minagawa A, Otani Y, Kubota T, Wada N, Furukawa T, Kumai K, Kameyama K, Okada Y, Fujii M, Yano M, Sato T, Ito A, Kitajima M|날짜=2001|권=92|호=12|쪽=1322-1328|doi=|pmid=11749698}}</ref><ref>{{저널 인용|제목=Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells|저널=Cancer Res|성=Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A.|날짜=2002|권=62|호=4|쪽=1025-1029|doi=|pmid=11861377}}</ref><ref>{{저널 인용|제목=Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation|저널=Aliment Pharmacol Ther|성=Yoshimizu N, Otani Y, Saikawa Y, Kubota T, Yoshida M, Furukawa T, Kumai K, Kameyama K, Fujii M, Yano M, Sato T, Ito A, Kitajima M|날짜=2004|권=1|쪽=95-101|doi=10.1111/j.1365-2036.2004.02082.x|pmid=15298613}}</ref> 피부염 억제 작용,<ref>{{저널 인용|제목=Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes ''in vivo'' and ''in vitro''|저널=Biochem Pharmacol|성=Tanaka S, Sato T, Akimoto N, Yano M, Ito A|날짜=2004|권=68|쪽=433-439|doi=10.1016/j.bcp.2004.04.006|pmid=15242810}}</ref> 간염 억제 작용<ref>{{저널 인용|제목=Hepatoprotective effects of flavonoids from shekwasha (''Citrus depressa'') against D-galactosamine-induced liver injury in rats|저널=J Nutr Sci Vitaminol|성=Akachi T, Shiina Y, Ohishi Y, Kawaguchi T, Kawagishi H, Morita T, Mori M, Sugiyama K|날짜=2010|권=56|호=1|쪽=60-67|doi=10.3177/jnsv.56.60|pmid=20354348}}</ref> 등이 나타났다. [[연골]]의 분해를 억제하는 효과도 보고되었다.<ref>{{저널 인용|first=Y.|last=Henrotin|author2=C. Lambert |author3=D. Couchourel |author4=C. Ripoll |author5=E. Chiotelli  |date=January 2011|title=Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products|journal=Osteoarthritis and Cartilage|volume=19|issue=1|pages=1–21|doi=10.1016/j.joca.2010.10.017|pmid=21035558|url=http://www.oarsijournal.com/article/S1063-4584%2810%2900358-4/fulltext#sec3.8|accessdate=2011-12-27|doi-access=free}}</ref> 또한 배양 [[해마체|해마]] 세포에서 [[AMPA 수용체]]를 활성화시켜 [[신경 세포|뉴런]]의 [[장기강화]]을 촉진하는 것으로 나타났다.<ref>{{저널 인용|제목=Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus|저널=Eur J Pharmacol|성=Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y|날짜=2008|권=578|호=2-3|쪽=194-200|doi=10.1016/j.ejphar.2007.09.028|pmid=17976577}}</ref> 이로 인해 치매예방에 효과가 있는 것으로 연구보고가 되었다.

== 출처 ==
{{각주|2}}

== 외부 링크 ==
* [http://www.phytochemicals.info/phytochemicals/nobiletin.php Nobiletin], phytochemicals.info
[[분류:O-메틸화 플라보노이드]]