{{위키데이터 속성 추적}}
{{Infobox_gene}}
'''이기능성 퓨린 생합성 단백질'''({{llang|en|bifunctional purine biosynthesis protein}}), '''PURH'''는 사람에서 ATIC [[유전자]]에 의해 암호화되는 [[단백질]]이다.<ref name="pmid8567683">{{저널 인용|vauthors=Rayl EA, Moroson BA, Beardsley GP | title = The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping | journal = J Biol Chem | volume = 271 | issue = 4 | pages = 2225–33 |date=Mar 1996 | pmid = 8567683 | doi =  10.1074/jbc.271.4.2225| doi-access = free }}</ref><ref name="pmid9378707">{{저널 인용|vauthors=Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K | title = Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase | journal = J Biochem | volume = 122 | issue = 2 | pages = 309–13 |date=Nov 1997 | pmid = 9378707 | doi =  10.1093/oxfordjournals.jbchem.a021754}}</ref><ref name="entrez">{{웹 인용| title = Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471}}</ref>

ATIC는 [[5-아미노이미다졸-4-카복사마이드 리보뉴클레오타이드]](AICAR)로부터 [[이노신 일인산]](IMP)를 생성하는 효소를 암호화한다.

이 효소는 다음과 같이 2가지 기능을 가지고 있다.

* {{EC number|2.1.2.3}}: 5-아미노이미다졸-4-카복사마이드 리보뉴클레오타이드 폼일기전이효소
* {{EC number|3.5.4.10}}: IMP 사이클로가수분해효소

== 같이 보기 ==
* [[이노신 일인산]] (IMP)

== 각주 ==
{{각주}}

== 더 읽을거리 ==
{{참고 자료 시작| 2}}
* {{저널 인용| author=Rasmussen HH |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199  |name-list-style=vanc| author2=van Damme J  | author3=Puype M  | display-authors=3  | last4=Gesser  | first4=Borbala  | last5=Celis  | first5=Julio E.  | last6=Vandekerckhove  | first6=Joël  |s2cid=41855774 }}
* {{저널 인용| author=Yamauchi M |title=Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript |journal=DNA Res. |volume=2 |issue= 6 |pages= 269–75 |year= 1996 |pmid= 8867801 |doi=10.1093/dnares/2.6.269  |name-list-style=vanc| author2=Seki N  | author3=Mita K  | display-authors=3  | last4=Saito  | first4=T  | last5=Tsuji  | first5=S  | last6=Hongo  | first6=E  | last7=Morimyo  | first7=M  | last8=Shiomi  | first8=T  | last9=Koyama  | first9=H  | doi-access=free  }}
* {{서적 인용| author=Beardsley GP |title=Purine and Pyrimidine Metabolism in Man IX |volume=431 |pages= 221–6 |year= 1998 |pmid= 9598063 |doi=10.1007/978-1-4615-5381-6_43  |name-list-style=vanc| author2=Rayl EA  | author3=Gunn K  | display-authors=3  | last4=Moroson  | first4=BA  | last5=Seow  | first5=H  | last6=Anderson  | first6=KS  | last7=Vergis  | first7=J  | last8=Fleming  | first8=K  | last9=Worland  | first9=S  |chapter=Structure and Functional Relationships in Human pur H | series=Advances in Experimental Medicine and Biology  | isbn=978-0-306-45778-4  }}
* {{저널 인용|vauthors=Vergis JM, Bulock KG, Fleming KG, Beardsley GP |title=Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7727–33 |year= 2001 |pmid= 11096114 |doi= 10.1074/jbc.M009940200 |doi-access= free }}
* {{저널 인용|vauthors=Bulock KG, Beardsley GP, Anderson KS |title=The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22168–74 |year= 2002 |pmid= 11948179 |doi= 10.1074/jbc.M111964200 |doi-access= free }}
* {{저널 인용| author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
* {{저널 인용| author=Cheong CG |title=Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 18034–45 |year= 2004 |pmid= 14966129 |doi= 10.1074/jbc.M313691200  |name-list-style=vanc| author2=Wolan DW  | author3=Greasley SE  | display-authors=3  | last4=Horton  | first4=PA  | last5=Beardsley  | first5=GP  | last6=Wilson  | first6=IA | doi-access=free}}
* {{저널 인용| author=Marie S |title=AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1276–81 |year= 2004 |pmid= 15114530 |doi= 10.1086/421475  | pmc=1182092  |name-list-style=vanc| author2=Heron B  | author3=Bitoun P  | display-authors=3  | last4=Timmerman  | first4=Thérèse  | last5=Van Den Berghe  | first5=Georges  | last6=Vincent  | first6=Marie-Françoise }}
* {{저널 인용| author=Dervieux T |title=Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis |journal=Arthritis Rheum. |volume=50 |issue= 9 |pages= 2766–74 |year= 2004 |pmid= 15457444 |doi= 10.1002/art.20460  |name-list-style=vanc| author2=Furst D  | author3=Lein DO  | display-authors=3  | last4=Capps  | first4=Robert  | last5=Smith  | first5=Katie  | last6=Walsh  | first6=Michael  | last7=Kremer  | first7=Joel | doi-access=free  }}
* {{저널 인용| author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
* {{저널 인용| author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-style=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
{{참고 자료 끝}}

== 외부 링크 ==
* {{MeshName|Inosine+monophosphate+synthase}}
* {{PDBe-KB2|P31939|Human Bifunctional purine biosynthesis protein PURH (Inosine monophosphate synthase)}}


{{PDB Gallery|geneid=471}}
{{탄소 원자 1개로 구성된 작용기 전이효소}}
{{탄소-질소 비펩타이드 가수분해효소}}
{{뉴클레오타이드 대사 효소}}

[[분류:인간 2번 염색체상 유전자]]