{{위키데이터 속성 추적}}
{{drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 416898838
| IUPAC_name = 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-''N,N''-dimethyl-2,2-diphenylbutanamide
| image = Loperamide.svg
| width = 250
| image2 = Loperamide 3D ball.png
| width2 = 235
<!--Clinical data-->
| pronounce = {{IPAc-en|l|oʊ|ˈ|p|ɛr|ə|m|aɪ|d}}
| tradename = Imodium, others<ref name=Names/>
| Drugs.com = {{drugs.com|monograph|loperamide-hydrochloride}}
| MedlinePlus = a682280
| pregnancy_AU = B3
| pregnancy_US = C
| legal_AU = S2
| legal_CA = OTC
| legal_UK = GSL
| legal_US = OTC
| routes_of_administration = by mouth
<!--Pharmacokinetic data-->
| bioavailability = 0.3%
| protein_bound = 97%
| metabolism = [[간]] (extensive)
| elimination_half-life = 9–14 hours<ref name=AHFS2015/>
| excretion = Faeces (30–40%), urine (1%)
<!--Identifiers-->
| IUPHAR_ligand = 7215
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 53179-11-6
| CAS_supplemental = <br />{{CAS|34552-83-5}}  (with HCl)
| ATC_prefix = A07
| ATC_suffix = DA03
| ATC_supplemental = <br />{{ATC|A07|DA05}} (oxide)
| PubChem = 3955
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00836
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3818
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6X9OC3H4II
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08144
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 6532
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 841
| synonyms = R-18553
<!--Chemical data-->
| C=29 | H=33 | Cl=1 | N=2 | O=2
| molecular_weight = 477.037 g/mol (513.506 with HCl)
| SMILES = ClC1=CC=C(C2(CCN(CC2)CCC(C3=CC=CC=C3)(C(N(C)C)=O)C4=CC=CC=C4)O)C=C1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RDOIQAHITMMDAJ-UHFFFAOYSA-N
}}
'''로페라미드'''(Loperamide, 상품명: Imodium 등)<ref name=Names>Drugs.com [http://www.drugs.com/international/loperamide.html International brands for loperamide] Page accessed Sept 4, 2015</ref>는 [[설사]]의 빈도수를 낮추기 위하여 사용되는 약물이다.<ref name=AHFS2015>{{웹 인용|title=Loperamide Hydrochloride|url=http://www.drugs.com/monograph/loperamide-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=Aug 25, 2015}}</ref> [[장염]], [[염증창자질환]], [[단장증후군]]에 대해 종종 사용된다. [[이질|혈변]]이 있는 환자에게는 권고되지 않는다. 이 약물은 구강으로 복용한다.<ref name=AHFS2015/>

로페라미드는 1969년 처음 제조되어 1976년에 의학적으로 이용이 시작되었다.<ref>{{서적 인용|last1=Patrick|first1=Graham L.|title=An introduction to medicinal chemistry|date=2013|publisher=Oxford University Press|location=Oxford|isbn=9780199697397|page=644|edition=Fifth edition.|ref=https://books.google.ca/books?id=Pj7xJRuhZxUC&pg=PA644}}</ref> [[의료제도]]에 필수적인, 가장 효과적이고 안전한 약물이 나열된 [[WHO 필수 약물 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015}}</ref> 로페라미드는 [[제네릭 의약품]]으로 이용 가능하다.<ref name=AHFS2015/><ref name=Ric2013>{{서적 인용|last1=Hamilton|first1=Richard J.|title=Tarascon pocket pharmacopoeia|date=2013|publisher=Jones & Bartlett Learning|location=[Sudbury, Mass.]|isbn=9781449673611|page=217|edition=14|url=https://books.google.ca/books?id=zJay-fZCFGgC&pg=PA217}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://imodium.com/ Imodium website]

{{전거 통제}}

[[분류:알코올]]
[[분류:지사제]]
[[분류:벨기에의 발명품]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:클로로아렌]]
[[분류:존슨앤드존슨의 제품]]
[[분류:뮤 오피오이드 수용체 작용제]]
[[분류:합성 오피오이드]]
[[분류:얀센제약]]
[[분류:4-페닐피페리딘]]
[[분류:HERG 차단제]]