{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 457457495
| IUPAC_name = (3''R'',4''S'',5''S'',6''R'',7''R'',9''R'',11''S'',12''R'',13''S'',14''R'')-6-<nowiki/>{[(2''S'',3''R'',4''S'',6''R'') -4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy} -14-ethyl-12,13-dihydroxy-4-<nowiki/>{[(2''R'',4''R'',5''S'',6''S'')-5-hydroxy -4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7 -methoxy-3,5,7,9,11,13-hexamethyl -1-oxacyclotetradecane-2,10-dione
| image = Clarithromycin structure.svg
| width = 250
| image2 = Clarithromycin ball-and-stick.png

<!--Clinical data-->
| tradename = Biaxin, others
| Drugs.com = {{drugs.com|monograph|clarithromycin}}
| MedlinePlus = a692005
| pregnancy_category = C ([[미국|USA]]) <br /> B3 ([[오스트레일리아|Aus]])
| legal_status = rx only
| routes_of_administration = [[경구 투여]], [[정맥 주사]]
<!--Pharmacokinetic data-->
| bioavailability = 50%
| protein_bound = 단백질 결합 적음
| metabolism = [[간]]
| elimination_half-life = 3~4시간

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 81103-11-9
| ATC_prefix = J01
| ATC_suffix = FA09
| PubChem = 5284534
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01211
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 10342604
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = H1250JIK0A
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00276
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1741

<!--Chemical data-->
| C=38 | H=69 | N=1 | O=13
| molecular_weight = 747.953 g/mol
| smiles = CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O
|  StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
|  StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = AGOYDEPGAOXOCK-KCBOHYOISA-N
| class = [[:en:Macrolides]]
}}

'''클래리스로마이신'''({{lang|en|clarithromycin}}, 판매되는 상표명: '''Biaxin''' 등)은 다양한 [[세균]] 감염을 치료하기 위해 사용되는 [[항생물질]]이다.<ref name=AHFS2015>{{웹 인용|title=Clarithromycin|url=https://www.drugs.com/monograph/clarithromycin.html|publisher=The American Society of Health-System Pharmacists|accessdate=September 4, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150903071907/http://www.drugs.com/monograph/clarithromycin.html|archivedate=September 3, 2015|df=}}</ref> 여기에는 [[연쇄상 구균 인두염]], [[폐렴]], 피부 감염, [[헬리코박터 파일로리|H. 파일로리]] 감염, [[라임병]] 등이 포함된다.<ref name=AHFS2015/> 클래리스로마이신은 알약 또는 액체 형태로 구강으로 섭취할 수 있다.<ref name=AHFS2015/>

일반적인 부작용은 메스꺼움, 구토, 두통, 설사가 포함된다.<ref name=AHFS2015/> 심각한 [[알레르기|알레르기 반응]]은 드문 편이다.<ref name=AHFS2015/> 간 질환이 보고되고 있다.<ref name=AHFS2015/> [[임신]] 중에 복용 시 위험을 초래할 수 있다.<ref name=AHFS2015/> [[매크롤라이드]]계 약물에 속하며 일부 박테리아의 단백질 생성을 감소시킴으로써 동작한다.<ref name=AHFS2015/>

클래리스로마이신은 1980년 개발되었으며 1990년 의학용으로 승인되었다.<ref name=Green2008>{{서적 인용|last1=Greenwood|first1=David|title=Antimicrobial drugs : chronicle of a twentieth century medical triumph|date=2008|publisher=Oxford University Press|location=Oxford|isbn=9780199534845|page=239|edition=1|url=https://books.google.ca/books?id=i4_FZHmzjzwC&pg=PA239|url-status=live|archiveurl=https://web.archive.org/web/20160305044428/https://books.google.ca/books?id=i4_FZHmzjzwC&pg=PA239|archivedate=2016-03-05|df=}}</ref><ref name=Fis2006>{{서적 인용|last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=498 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA498 |language=en}}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}}</ref> 클래리스로마이신은 제네릭 의약품으로 구매가 가능하다.<ref name=AHFS2015/> [[개발도상국]]의 도매가는 1회 복용량 기준 US$0.13 ~ $0.79 사이이다.<ref name=ERC2014>{{웹 인용|title=Clarithromycin|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=1071&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=7 September 2015|보존url=https://web.archive.org/web/20180702011212/http://mshpriceguide.org/en/single-drug-information/?DMFId=1071&searchYear=2014|보존날짜=2018-07-02|url-status=dead}}</ref> 미국의 경우 1회 치료 당 $50–100로, 보통 비싼 편이다.<ref name=Ric2015>{{서적 인용|last1=Hamilton|first1=Richart|title=Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition|date=2015|publisher=Jones & Bartlett Learning|isbn=9781284057560|page=92}}</ref> [[에리트로마이신]]으로부터 만들며 화학적으로는 6-O-메틸에리트로마이신(6-O-methylerythromycin)으로 알려져 있다.<ref>{{서적 인용|last1=Kirst|first1=Herbert A.|title=Macrolide Antibiotics|date=2012|publisher=Birkhäuser Basel|location=Basel|isbn=9783034881050|page=53|edition=2|url=https://books.google.ca/books?id=8Vn2BwAAQBAJ&pg=PA53|url-status=live|archiveurl=https://web.archive.org/web/20160305031148/https://books.google.ca/books?id=8Vn2BwAAQBAJ&pg=PA53|archivedate=2016-03-05|df=}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
{{위키공용분류}}
* {{웹 인용| url = http://www.rxabbott.com/pdf/biapi.PDF | title = Biaxin XL (labeling) | publisher = [[:en:Abbott Laboratories]] }}
* {{ cite patent | country = US | title = Novel erythromycin compounds | number = 4331803 | status = patent | invent1 = Watanabe, Y. | invent2 = Morimoto, S. | invent3 = Omura, S. | assign1 = Taisho Pharmaceutical | gdate = 1981-05-19 }}
* [https://www.fda.gov/downloads/Drugs/DrugSafety/UCM597723.pdf FDA Drug Safety Communication, "FDA review finds additional data supports the potential for increased long-term risks with antibiotic clarithromycin (Biaxin) in patients with heart disease."]

{{전거 통제}}

[[분류:세계 보건 기구 필수 의약품]]
[[분류:애브비의 제품]]
[[분류:CYP3A4 억제제]]
[[분류:마크롤라이드 항생제]]
[[분류:다이메틸아미노 화합물]]