{{위키데이터 속성 추적}}
{{질병 정보 (신규)
 | 이름             = 다발성 내분비종양증
 | 그림             = Medullary thyroid carcinoma - 2 - high mag.jpg
 | 그림설명         = [[갑상선수질암]]의 현미경 사진. MEN 2A와 MEN 2B로 관찰할 수 있다. [[H&E 염색]].
}}
'''다발성 내분비종양증'''(多發性內分泌腫瘍症, {{lang|en|multiple endocrine neoplasia}}, MEN)은 [[내분비선성신생물]] 각각이 자신만의 특징적 패턴을 갖는 여러 [[증후군]]을 통틀어 일컫는다. '''다발성내분비샘종'''(多發性內分泌腺腫)이라고도 한다. 일부의 경우 [[종양]]은 악성이며 그 밖의 것들은 양성이다. 비내분비계 조직의 양성이나 악성 종양들은 이러한 종양 증후군들 중 일부의 성분으로 발생한다.

MEN 증후군들은 [[우성 (유전학)|상염색체 우성]] 질병으로 유전된다.<ref>{{DorlandsDict|six/000070637|multiple endocrine neoplasia}}</ref>

== 비교 ==
{| class="wikitable"
|-
! rowspan="2" | 기능
! rowspan="2" | [[MEN 1]]
! colspan="3" | [[MEN 2]]
|-
! [[MEN 2|MEN 2A]]
! [[MEN 2b|MEN 2B]]
! [[갑상선수질암|FMTC]]
|-
| [[시조]]
| 워머 증후군
| 시플 증후군
| (다수)
| (없음)
|-
| [[OMIM]]
| {{OMIM4|131100}}
| {{OMIM4|171400}}
| {{OMIM4|162300}}
| {{OMIM4|155240}}
|-
| [[이자 (해부학)|이자]] 종양
| [[가스트린종]] (50%<ref name=agabegi2nd4-7/>), <br />[[:en:insulinoma]] (20%<ref name=agabegi2nd4-7/>), <br />[[:en:vipoma]], <br />[[:en:glucagonoma]], <br />[[PPoma]]
| -
| -
| -
|-
| [[뇌하수체 샘종]]
| 66%<ref name=agabegi2nd4-7>Table 4-7 in:{{서적 인용|author1=Elizabeth D Agabegi |author2=Agabegi, Steven S. |title=Step-Up to Medicine (Step-Up Series) |publisher=Lippincott Williams & Wilkins |location=Hagerstwon, MD |year=2008 |pages= |isbn=0-7817-7153-6 |oclc= |doi= |accessdate=}}</ref>
| -
| -
| -
|-
| [[혈관섬유종]]
| 64%*<ref name=Asgharian>{{저널 인용|last=Asgharian|first=B |author2=Turner, ML |author3=Gibril, F |author4=Entsuah, LK |author5=Serrano, J |author6=Jensen, RT|title=Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity for MEN1.|journal=The Journal of Clinical Endocrinology and Metabolism|date=November 2004|volume=89|issue=11|pages=5328-36|pmid=15531478|doi=10.1210/jc.2004-0218}}</ref>
| -
| -
| -
|-
| [[지방종]]
| 17%*<ref name=Asgharian />
| -
| -
| -
|-
| [[부갑상샘]] 과다형성
| 90%<ref name=agabegi2nd4-7/>
| 50%<ref name=agabegi2nd4-7/>
| -
| -
|-
| [[갑상선수질암]]
| -
| 100%<ref name=agabegi2nd4-7/>
| 85%<ref name=agabegi2nd4-7/>
| 100%
|-
| [[크롬친화세포종]]
| -
| >33%<ref name=agabegi2nd4-7/>
| 50%
| -
|-
| [[마르판 증후군|마르판]] 체형
| -
| -
| 80%
| -
|-
| 점막 [[신경종]]
| -
| -
| 100%<ref name=agabegi2nd4-7/>
| -
|-
| [[유전자]](s)
| [[:en:MEN1]] ({{OMIM4|131100}})
| [[:en:RET proto-oncogene|RET]] ({{OMIM4|164761}})
| [[:en:RET proto-oncogene|RET]] ({{OMIM4|164761}})
| [[:en:RET proto-oncogene|RET]] ({{OMIM4|164761}}),<br/>[[:en:NTRK1]] ({{OMIM4|191315}})
|-
| 대략 [[유병률]]
| 1 in 35,000 <br /> (1 in 20,000 ~<br /> 1 in 40,000)<ref>[http://www.dovepress.com/getfile.php?fileID=5129] {{웨이백|url=http://www.dovepress.com/getfile.php?fileID=5129 |date=20120523034756 }} 123I labeled metaiodobenzylguanidine for diagnosis of neuroendocrine tumors. Jiang L, Schipper ML, Li P, Cheng Z, Reports in Medical Imaging. 2009: 2 79-89</ref>
| 1 in 40,000<ref>{{저널 인용|vauthors=Dora JM, Siqueira DR, Meyer EL, Punales MK, Maia AL |title=Pancreatitis as the first manifestation of multiple endocrine neoplasia type 2A |journal=Arq Bras Endocrinol Metabol |volume=52 |issue=8 |pages=1332-6 |date=November 2008 |pmid=19169490 |doi= 10.1590/S0004-27302008000800021|url=}}</ref>
| 1 in 1,000,000<br/>(1 in 600,000<ref>{{서적 인용|last=Marx |first=Stephen J |editor-last=Melmed |editor-first=Shlomo |title=Williams Textbook of Endocrinology, 12th ed. |year=2011 |pages=1728-1767 |chapter=Chapter 41: Multiple endocrine neoplasia }}</ref> ~<br/>1 in 4,000,000<ref>{{저널 인용|vauthors=Moline J, Eng C |title= Multiple endocrine neoplasia type 2: An overview|journal=Genetics in Medicine |volume=13 |issue=9 |pages=755-764 |year=2011 |pmid= 21552134 |url=http://www.nature.com/gim/journal/v13/n9/full/gim2011127a.html |doi=10.1097/GIM.0b013e318216cc6d}}</ref>)<ref>{{서적 인용|author=Martino Ruggieri |title=Neurocutaneous Disorders : The Phakomatoses |publisher=Springer |location=Berlin |year=2005 |pages= |isbn=3-211-21396-1 |oclc= |doi= |accessdate=}} - Chapter: ''Multiple Endocrine Neoplasia Type 2B '' by Electron Kebebew, Jessica E. Gosnell and Emily Reiff. Pages 695-701. [http://www.springerlink.com/content/qu78313220701167/]{{깨진 링크|url=http://www.springerlink.com/content/qu78313220701167/ }}  This reference quotes a prevalence of 1 in 40,000, but this figure is inconsistent with the same reference's calculated incidence of 4 per 100 million per year for MEN2B.</ref>
|
|-
| 초기 언급 (연도)
| 1954<ref>{{저널 인용 |author=Wermer P |title=Genetic aspects of adenomatosis of endocrine glands |journal=Am. J. Med. |volume=16 |issue=3 |pages=363-71 |year=1954 |pmid=13138607 |doi=10.1016/0002-9343(54)90353-8 |url=http://linkinghub.elsevier.com/retrieve/pii/0002-9343(54)90353-8 |확인날짜=2017-03-13 |보존url=https://web.archive.org/web/20191215080908/http://linkinghub.elsevier.com/retrieve/pii/0002-9343(54)90353-8 |보존날짜=2019-12-15 |url-status=dead }}</ref>
| 1961<ref>{{저널 인용|author=Sipple JH |title=The association of pheochromocytoma with carcinoma of the thyroid gland |journal=Am. J. Med. |volume=31 |issue= |pages=163-6 |year=1961 |pmid= |doi= 10.1016/0002-9343(61)90234-0|url=}}</ref>
| 1965
|
|}
<nowiki>*</nowiki>- MEN1 및 가스트린종 환자

FMTC = familial medullary thyroid cancer

== 각주 ==
{{각주}}

== 외부 링크 ==
{{Medical resources
|  DiseasesDB     = 
|  ICD10          = {{ICD10|E|31|20}}
|  ICD9           = {{ICD9|258.0}}
|  ICDO           = 8360/1
|  OMIM           = 
|  MedlinePlus    = 000398
|  eMedicineSubj  = 
|  eMedicineTopic = 
|  MeshID         = D009377
}}


* {{언어링크|en}} [http://endocrine.niddk.nih.gov/ Endocrine and Metabolic Diseases Information Service] {{웨이백|url=http://endocrine.niddk.nih.gov/ |date=20120515234300 }}
* {{언어링크|en}} [http://www.amend.org.uk/ The Association for Multiple Endocrine Neoplasia Disorders (AMEND)]
* {{언어링크|en}} [http://www.arup.utah.edu/database/MEN2/MEN2_welcome.php/ Multiple Endocrine Neoplasia type 2 (MEN2 RET database)]

{{전거 통제}}
{{토막글|질병}}

[[분류:내분비 질환]]
[[분류:상염색체 우성 질환]]
[[분류:내분비 신생물]]