{{위키데이터 속성 추적}}
{{Infobox drug
| type =<!-- empty -->
| IUPAC_name = 4-Methyl-1''H''-pyrazole
| image = Fomepizole.svg
| width = 125px
| alt = Skeletal formula of fomepizole
| image2 = Fomepizole 3D ball.png
| width2 = 125px
| alt2 = Ball-and-stick model of the fomepizole molecule
| caption = Chemical structure of fomepizole.

<!-- Clinical data -->
| pronounce = 
| tradename = Antizol, others
| Drugs.com = {{Drugs.com|monograph|fomepizole}}
| MedlinePlus = 
| licence_EU = <!-- EMA requires brand name -->
| licence_US = <!-- FDA may use generic name -->
| DailyMedID = <!-- preference to licence_US -->
| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X -->
| pregnancy_AU_comment = 
| pregnancy_US = C
| pregnancy_US_comment = 
| pregnancy_category= 
| dependency_liability = 
| addiction_liability = 
| routes_of_administration = [[정맥 주사]]
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU_comment = 
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment = 
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment = 
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment = 
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment = 
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US_comment = 
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment = 
| legal_status = <!--For countries not listed above-->
<!-- Pharmacokinetic data -->
| bioavailability = 
| protein_bound = 
| metabolism = 
| metabolites =
| onset = 
| elimination_half-life = 
| duration_of_action =
| excretion =
<!-- Identifiers -->
| CAS_number = 7554-65-6
| CAS_supplemental = {{cascite|correct|CAS}}
| ATCvet = 
| ATC_prefix = V03
| ATC_suffix = AB34
| ATC_supplemental = 
| PubChem = 3406
| PubChemSubstance = 
| IUPHAR_ligand = 
| DrugBank = DB01213
| ChemSpiderID = 3289
| UNII = 83LCM6L2BY
| KEGG = D00707
| ChEBI = 5141
| ChEMBL = 1308
| NIAID_ChemDB =
| synonyms = 4-Methylpyrazole
<!-- Chemical data -->
| charge=
| molecular_weight = 
| SMILES = Cc1cn[nH]c1
| Jmol = 
| StdInChI = 1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RIKMMFOAQPJVMX-UHFFFAOYSA-N
| density = 
| density_notes = 0.99 g/cm<sup>3</sup>
| melting_point = 
| melting_high = 
| melting_notes = 
| boiling_point = 204 ~ 207
| boiling_notes = (97,3 kPa 기준)
| solubility = 
| specific_rotation = 
}}
'''포메피졸'''({{lang|en|Fomepizole}}) 또는 '''4-메틸피라졸'''(4-methylpyrazole)은 [[메탄올 중독|메탄올]]과 [[에틸렌글라이콜 중독]]을 치료하기 위해 사용되는 약물이다.<ref name=AHFS2016/> 단독 사용되거나 [[혈액 투석]]과 함께 사용할 수 있다.<ref name=AHFS2016/> [[정맥 주사]]를 통해 이루어진다.<ref name=AHFS2016>{{웹 인용|title=Fomepizole|url=https://www.drugs.com/monograph/fomepizole.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161221003710/https://www.drugs.com/monograph/fomepizole.html|archivedate=21 December 2016|df=}}</ref>

공통 부작용으로는 두통, 구역질, 불면증, 불안정 등이 있다.<ref name=AHFS2016/> [[임신]] 중에 복용하는 것이 태아에 안전한지에 대해서는 명확하지 않다.<ref name=AHFS2016/> 포메피졸은 [[메탄올]]과 [[에틸렌글리콜]]을 독성 분해 산물로 변환하는 [[효소]]를 차단함으로써 동작한다.<ref name=AHFS2016/>

포메피졸은 1997년 미국에서 의학 용도로 승인되었다.<ref name=AHFS2016/> [[의료 체계]]에 필수적인 가장 효과적으로 안전한 의약 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}}</ref> 미국에서 개별 약병 가격은 약 1000 미국 달러이다.<ref>{{서적 인용|last1=Wolfson|first1=Allan B.|last2=Hendey|first2=Gregory W.|last3=Ling|first3=Louis J.|last4=Rosen|first4=Carlo L.|last5=Schaider|first5=Jeffrey J.|last6=Sharieff|first6=Ghazala Q.|title=Harwood-Nuss' Clinical Practice of Emergency Medicine|date=2012|publisher=Lippincott Williams & Wilkins|isbn=9781451153453|page=1376|edition=5|url=https://books.google.ca/books?id=wwws22gAykYC&lpg=PT1409|language=en|url-status=live|archiveurl=https://web.archive.org/web/20161220113501/https://books.google.ca/books?id=wwws22gAykYC&lpg=PT1409|archivedate=2016-12-20|df=}}</ref>

== 기타 이용 ==
의학용도 외에 [[배위화합물|배위화학]]에서 4-메틸피라졸의 역할이 연구되고 있다.<ref>{{저널 인용| doi = 10.1007/BF00619054 | title = Pyrazolato and related anions. Part V. Transition metal salts of 4-methylpyrazole | year = 1979 | author = Vos, Johannes G. | journal = Transition Metal Chemistry | volume = 4 | issue = 3 | pages = 137–141 | last2 = Groeneveld | first2 = Willem L.}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* [https://web.archive.org/web/20090728052842/http://www.antizol.com/ Antizol]
* [https://web.archive.org/web/20110707151058/http://www.antizol.com/pdf/JAZ%204879-Antizol%20Monograph%204-16-07.pdf Antizol Product Monograph]
* [https://www.drugs.com/MMX/Fomepizole.html Advanced Consumer Drug Information] {{웨이백|url=https://www.drugs.com/MMX/Fomepizole.html |date=20160304212439 }}
{{해독제}}

[[분류:해독제]]
[[분류:세계 보건 기구 필수 의약품]]