{{위키데이터 속성 추적}}
'''작용 방식'''(作用方式, {{llang|en|mode of action}}, '''MoA''')은 [[약리학]] 및 [[생화학]]에서 살아 있는 [[생물]]이 물질에 노출되어 일어나는 기능적 또는 해부학적 변화를 설명한다.<ref name=":0" /> 이에 비해 [[작용 메커니즘]](MOA)은 분자 수준에서 이러한 변화를 설명한다.<ref>{{웹 인용|title=Mechanisms and mode of dioxin action | url= http://www.epa.gov/ncea/pdfs/dioxin/nas-review/pdfs/part3/dioxin_pt3_ch03_oct2004.pdf | publisher = US EPA | access-date=11 June 2012 | archive-url = https://web.archive.org/web/20150226023800/http://www.epa.gov/ncea/pdfs/dioxin/nas-review/pdfs/part3/dioxin_pt3_ch03_oct2004.pdf | archive-date= 26 February 2015 | url-status = dead }}</ref><ref name=":0">{{서적 인용| editor-last1 = McQueen | editor-first1 = Charlene A. | title = Comprehensive Toxicology | date = 2010 | publisher = Elsevier | location = Oxford | isbn = 978-0-08-046884-6 | edition = 2nd | vauthors = Grant RL, Combs AB, Acosta D | chapter = Experimental Models for the Investigation of Toxicological Mechanisms | chapter-url = https://books.google.com/books?id=jzCAKsa2CpMC&q=mechanism+mode+action+drug+definition+molecular+cellular&pg=PA204 | page = 204 }}</ref>

작용 방식은 특히 정확한 분자 표적이 아직 밝혀지지 않았거나 논쟁의 대상이 될 때 분자 메커니즘과 생리학적 결과 사이의 중간 수준의 복잡성을 나타내기 때문에 화학 물질을 분류하는 데 중요하다. 화학 물질의 작용 메커니즘은 "DNA에 결합"하는 것이고, 보다 넓은 작용 방식은 "전사 조절"일 수 있다.<ref>{{저널 인용|last=Ng|first=Wai-Leung|author2=Krystyna M. Kazmierczak |author3=Gregory T. Robertson |author4=Raymond Gilmour |author5=Malcolm E. Winkler |title=Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of ''Streptococcus Pneumoniae'' R6 Challenged with Sublethal Concentrations of Translation Inhibitors| journal = Journal of Bacteriology | volume = 185 | issue = 1 | pages = 359–70 | date = Jan 2003 | pmid = 12486074 | doi = 10.1128/JB.185.1.359-370.2003 | pmc=141824}}</ref> 그러나 여기에는 명확히 합의된 것이 없으며 특정 [[핵 수용체]] 또는 [[효소]]에 대한 작용과 같은 분자 메커니즘을 설명하기 위해 특히 [[살충제]] 연구에서 작용 방식이라는 용어가 자주 사용된다.<ref>{{웹 인용| title = Herbicide Group Classification by Mode of Action | url = http://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/prm6487 | publisher = Alberta Agriculture and Rural Development | access-date = 11 June 2012 | archive-url=https://web.archive.org/web/20190123004800/http://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/prm6487 | archive-date=2019-01-23}}</ref><ref name="FRAC-MoAs">{{웹 인용|url=http://www.frac.info/docs/default-source/publications/frac-code-list/frac-code-list-2021--final.pdf|title=FRAC Code List ©*2021: Fungal control agents sorted by cross resistance pattern and mode of action (including coding for FRAC Groups on product labels)|author=FRAC (Fungicide Resistance Action Committee)|date=March 2021|archive-url=https://web.archive.org/web/20211105005300/https://www.frac.info/docs/default-source/publications/frac-code-list/frac-code-list-2021--final.pdf|archive-date=2021-11-05|url-status=dead|access-date=2021-04-02}}</ref><ref name="WSSA-MOA-summary">{{웹 인용|url=http://wssa.net/wp-content/uploads/WSSA-Mechanism-of-Action.pdf|title=Summary of Herbicide Mechanism of Action According to the Weed Science Society of America (WSSA)|author=Weed Science Society of America|archive-url=https://web.archive.org/web/20221008132104/https://www.wssa.net/wp-content/uploads/WSSA-Mechanism-of-Action.pdf|archive-date=2022-10-08|url-status=live|access-date=2021-04-02}}</ref><ref name="Heap-WSSA-MOAs">{{웹 인용| url=http://www.weedscience.org/Documents/ShowDocuments.aspx?DocumentID=1192 | title=HERBICIDE MODE OF ACTION TABLE | last=Heap | first=Ian | access-date=2021-04-02 | archive-date=2022-07-05 | archive-url=https://web.archive.org/web/20220705133439/https://weedscience.org/Documents/ShowDocuments.aspx?DocumentID=1192 | url-status=live }}</ref><ref name="HRAC-MOA-2020">{{웹 인용|url=http://hracglobal.com/tools/hrac-moa-2020-revision-description-and-master-herbicide-list|title=HRAC MOA 2020 Revision Description and Master Herbicide List|date=2020-09-14|website=Herbicide Resistance Action Committee|archive-url=https://web.archive.org/web/20230115130638/https://hracglobal.com/tools/hrac-moa-2020-revision-description-and-master-herbicide-list|archive-date=2023-01-15|url-status=live|access-date=2021-04-01}}</ref><ref name="IRAC-MoA-2020">{{웹 인용|url=http://irac-online.org/modes-of-action/|title=Interactive MoA Classification|date=2020-09-16|website=Insecticide Resistance Action Committee|archive-url=https://web.archive.org/web/20220808102513/https://irac-online.org/modes-of-action/|archive-date=2022-08-08|url-status=live|access-date=2021-04-01}}</ref><ref name="EPA-guidance">{{웹 인용|url=http://www.epa.gov/sites/production/files/2017-09/documents/prn-2017-1-pesticide-resistance-management-labeling.pdf|title=PESTICIDE REGISTRATION NOTICE (PRN) 2017-1 NOTICE TO MANUFACTURERS, PRODUCERS, PRODUCERS AND REGISTRANTS OF PESTICIDE PRODUCTS AND DEVICES|author=United States Environmental Protection Agency|archive-url=https://web.archive.org/web/20210323143812/https://www.epa.gov/sites/production/files/2017-09/documents/prn-2017-1-pesticide-resistance-management-labeling.pdf|archive-date=2021-03-23|url-status=live|access-date=2021-04-02}}</ref>

== 같이 보기 ==
* [[작용 메커니즘]] ([[약학]]에서)
* [[독성 발현 경로]]

== 각주 ==
{{각주}}

[[분류:약물동역학]]
[[분류:의약화학]]