{{위키데이터 속성 추적}}
{{유전자 정보}}
'''베타-3 아드레날린 수용체''' (β<sub>3</sub> 아드레날린 수용체)는 '''ADRB3'''으로도 알려져 있는데, [[아드레날린 수용체|베타 아드레날린 수용체]]의 일종으로 이를 인코딩하는 인간 [[유전자]]를 지칭하기도 한다.<ref name="entrez">{{웹 인용| title = Entrez Gene: ADRB3 adrenergic, beta-3-, receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=155}}</ref>

== 작용 ==
β <sub>3</sub> 수용체의 작용에는 다음이 포함된다.

* [[지방 조직]]의 지방 분해 증진.<ref name="pmid15935402">{{저널 인용|제목=Combined effects of oleoyl-estrone and a β<sub>3</sub>-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats|저널=Life Sciences|url=https://zenodo.org/record/889563|날짜=September 2005|권=77|호=16|쪽=2051–8|doi=10.1016/j.lfs.2005.04.008|pmid=15935402}}</ref>
* [[골격근]]에서의 열발생<ref name="Rang163">{{서적 인용|제목=Pharmacology|url=https://archive.org/details/isbn_9788181479174|성=Rang, H. P.|연도=2003|출판사=Churchill Livingstone|위치=Edinburgh|isbn=0-443-07145-4}}</ref>

주로 [[지방 조직]]에 위치하며 지방 분해 및 열 발생 조절에 관여한다. 일부 β <sub>3</sub> [[효능제|작용제]]는 [[스트레스 관리|항 스트레스]] 효과가 동물 실험에서 밝혀졌는데, 이는 중추 신경계 (CNS)에서도 역할을 한다는 점을 암시한다. β <sub>3</sub> 수용체는 담낭, 방광 및 [[갈색지방조직|갈색 지방 조직]]에서 발견된다. 담낭 생리학에서 그들의 역할은 알려지지 않았지만 갈색 지방에서 지방 분해 및 열 발생에 역할을하는 것으로 생각된다. 방광에서는 방광의 이완과 배뇨 방지를 유발하는 것으로 알려져 있다.<ref name="pmid16457637">{{저널 인용|제목=Recent Developments in the Design of Orally Bioavailable β3-Adrenergic Receptor Agonists|저널=Current Medicinal Chemistry|연도=2006|권=13|호=1|쪽=25–37|doi=10.2174/092986706775198006|pmid=16457637}}</ref>

== 작용 메커니즘 ==
베타 아드레날린 수용체는 Gs 유형의 [[G단백질|G 단백질]]의 작용을 통하여 [[아드레날린|에피네프린]] 또는 [[노르에피네프린]]에 의하여 유도되는 [[아데닐레이트 사이클라제]]의 활성화에 관련되어 있다.<ref name="entrez"/>

== 리간드 ==
=== 작용제 ===
* Amibegron (SR-58611A)<ref name="pmid17669397">{{저널 인용|제목=Behavioral effects of the β<sub>3</sub> adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?|저널=European Journal of Pharmacology|날짜=November 2007|권=573|호=1–3|쪽=139–47|doi=10.1016/j.ejphar.2007.06.048|pmid=17669397}}</ref><ref name="pmid18358519">{{저널 인용|제목=Confirmation of antidepressant potential of the selective β<sub>3</sub> adrenoceptor agonist amibegron in an animal model of depression|url=https://archive.org/details/sim_pharmacology-biochemistry-and-behavior_2008-06_89_4/page/623|저널=Pharmacology Biochemistry and Behavior|날짜=June 2008|권=89|호=4|쪽=623–6|doi=10.1016/j.pbb.2008.02.020|pmid=18358519}}</ref>
* BRL-37344<ref name="pmid30892909">{{저널 인용|제목=BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization|저널=American Journal of Physiology. Regulatory, Integrative and Comparative Physiology|날짜=May 2019|권=316|호=5|쪽=R666–R677|doi=10.1152/ajpregu.00285.2018|pmid=30892909}}</ref>
* CL-316,243<ref>{{저널 인용|제목=The effects of beta(3)-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice|저널=European Journal of Pharmacology|연도=2008|권=584|호=1|쪽=202–6|doi=10.1016/j.ejphar.2008.01.028|pmid=18304529}}</ref>
* L-742,791<ref name="pmid10411574">{{저널 인용|제목=Potent and selective human beta(3)-adrenergic receptor antagonists.|저널=The Journal of Pharmacology and Experimental Therapeutics|날짜=Aug 1999|권=290|호=2|쪽=649–55|pmid=10411574}}</ref>
* L-796,568<ref name="pmid12324291">{{저널 인용|제목=Effect of a 28-d treatment with L-796568, a novel β<sub>3</sub>-adrenergic receptor agonist, on energy expenditure and body composition in obese men|url=https://archive.org/details/sim_american-journal-of-clinical-nutrition_2002-10_76_4/page/780|저널=The American Journal of Clinical Nutrition|연도=2002|권=76|호=4|쪽=780–8|doi=10.1093/ajcn/76.4.780|pmid=12324291}}</ref>
* LY-368,842
* Mirabegron (YM-178),<ref>{{저널 인용|제목=Mirabegron for the treatment of overactive bladder|저널=Drugs of Today|연도=2012|권=48|호=1|쪽=25–32|doi=10.1358/dot.2012.48.1.1738056|pmid=22384458}}</ref> 일본, 미국, 영국, 캐나다, 중국 및 인도에서 과민성 방광 치료로 승인됨.
* Nebivolol<ref>{{저널 인용|제목=Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart|저널=J Am Coll Cardiol|권=53|호=17|쪽=1532–8|doi=10.1016/j.jacc.2008.11.057|pmid=19389564}}</ref> 선택적 베타 (1) 차단제 및 베타 (3) 작용제.
* Ro40-2148
* 솔라베그론 (GW-427,353)<ref name="pmid17626794">{{저널 인용|제목=GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog|저널=The Journal of Pharmacology and Experimental Therapeutics|날짜=October 2007|권=323|호=1|쪽=202–9|doi=10.1124/jpet.107.125757|pmid=17626794}}</ref>
* Vibegron (MK-4618)<ref name="pmid17626795">{{저널 인용|제목=Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.|저널=Journal of Medicinal Chemistry|날짜=January 2016|권=59|호=2|쪽=609–23|doi=10.1021/acs.jmedchem.5b01372|pmid=26709102}}</ref>

=== 길항제 ===
* L-748,328<ref name="pmid10411574" />
* L-748,337<ref name="pmid10411574" />
* SR 59230A는 원래 선택적 β <sub>3</sub> [[수용체 대항제|길항제]]로 생각되었는데,<ref name="pmid8569714">{{저널 인용|제목=Functional studies of the first selective β<sub>3</sub>-adrenergic receptor antagonist SR 59230A in rat brown adipocytes|저널=Mol. Pharmacol.|연도=1996|권=49|호=1|쪽=7–14|pmid=8569714}}</ref> 그 후, α<sub>1</sub> 수용체의 길항제인 것으로 밝혀졌다.<ref name="pmid19422394">{{저널 인용|제목=Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse|저널=British Journal of Pharmacology|날짜=April 2009|권=158|호=1|쪽=259–66|doi=10.1111/j.1476-5381.2009.00186.x|pmc=2795232|pmid=19422394}}</ref>

== 상호 작용 ==
베타-3 아드레날린 수용체는 [[Src]]와 상호 작용하는 것으로 밝혀졌다.<ref name="pmid11013230">{{저널 인용|제목=Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation|저널=J. Biol. Chem.|연도=2000|권=275|호=49|쪽=38131–4|doi=10.1074/jbc.C000592200|pmid=11013230}}</ref>

== 같이 보기 ==
* 기타 [[아드레날린 수용체]]
** [[알파 -1 아드레날린 수용체]]
** [[알파 -2 아드레날린 수용체]]
** [[베타-1 아드레날린 수용체|베타 -1 아드레날린 수용체]]
** [[베타 -2 아드레날린 수용체]]
** [[베타 차단제]]

== 각주 ==
{{각주}}

== 추가 자료 ==
{{참고 자료 시작|35em}}
* {{저널 인용| vauthors = Granneman JG, Lahners KN, Rao DD | title = Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block | journal = Mol. Pharmacol. | volume = 42 | issue = 6 | pages = 964–70 | year = 1993 | pmid = 1336117 }}
* {{저널 인용| vauthors = Nahmias C, Blin N, Elalouf JM, Mattei MG, Strosberg AD, Emorine LJ | title = Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes | url = https://archive.org/details/sim_embo-journal_1991-12_10_12/page/3721 | journal = EMBO J. | volume = 10 | issue = 12 | pages = 3721–7 | year = 1991 | pmid = 1718744 | pmc = 453106 | doi =  10.1002/j.1460-2075.1991.tb04940.x}}
* {{저널 인용| vauthors = Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD | title = Molecular characterization of the human beta 3-adrenergic receptor | journal = Science | volume = 245 | issue = 4922 | pages = 1118–21 | year = 1989 | pmid = 2570461 | doi = 10.1126/science.2570461 }}
* {{저널 인용| vauthors = Guan XM, Amend A, Strader CD | title = Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor | journal = Mol. Pharmacol. | volume = 48 | issue = 3 | pages = 492–8 | year = 1995 | pmid = 7565630 }}
* {{저널 인용| vauthors = Rodriguez M, Carillon C, Coquerel A, Le Fur G, Ferrara P, Caput D, Shire D | title = Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain | url = https://archive.org/details/sim_molecular-brain-research_1995-04_29_2/page/369 | journal = Brain Res. Mol. Brain Res. | volume = 29 | issue = 2 | pages = 369–75 | year = 1995 | pmid = 7609625 | doi = 10.1016/0169-328X(94)00274-I }}
* {{저널 인용| vauthors = Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD | title = Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity | journal = N. Engl. J. Med. | volume = 333 | issue = 6 | pages = 352–4 | year = 1995 | pmid = 7609752 | doi = 10.1056/NEJM199508103330605 }}
* {{저널 인용| vauthors = Dib A, Adélaïde J, Chaffanet M, Imbert A, Le Paslier D, Jacquemier J, Gaudray P, Theillet C, Birnbaum D, Pébusque MJ | title = Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma | journal = Oncogene | volume = 10 | issue = 5 | pages = 995–1001 | year = 1995 | pmid = 7898940 }}
* {{저널 인용| vauthors = Mahmoudian M | title = The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study | journal = Journal of Molecular Graphics | volume = 12 | issue = 1 | pages = 22–8, 34 | year = 1994 | pmid = 8011597 | doi = 10.1016/0263-7855(94)80004-9 }}
* {{저널 인용| vauthors = Wilkie TM, Chen Y, Gilbert DJ, Moore KJ, Yu L, Simon MI, Copeland NG, Jenkins NA | title = Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors | journal = Genomics | volume = 18 | issue = 2 | pages = 175–84 | year = 1994 | pmid = 8288218 | doi = 10.1006/geno.1993.1452 }}
* {{저널 인용| vauthors = Krief S, Lönnqvist F, Raimbault S, Baude B, Van Spronsen A, Arner P, Strosberg AD, Ricquier D, Emorine LJ | title = Tissue distribution of beta 3-adrenergic receptor mRNA in man | url = https://archive.org/details/sim_journal-of-clinical-investigation_1993-01_91_1/page/344 | journal = J. Clin. Invest. | volume = 91 | issue = 1 | pages = 344–9 | year = 1993 | pmid = 8380813 | pmc = 330032 | doi = 10.1172/JCI116191 }}
* {{저널 인용| vauthors = van Spronsen A, Nahmias C, Krief S, Briend-Sutren MM, Strosberg AD, Emorine LJ | title = The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes | journal = Eur. J. Biochem. | volume = 213 | issue = 3 | pages = 1117–24 | year = 1993 | pmid = 8389293 | doi = 10.1111/j.1432-1033.1993.tb17861.x | doi-access = free }}
* {{저널 인용| vauthors = Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupre I, Delpech B, Bensaid M, LeFur G, Ferrara P | title = Molecular cloning of a human beta 3-adrenergic receptor cDNA | journal = FEBS Lett. | volume = 324 | issue = 2 | pages = 127–30 | year = 1993 | pmid = 8389717 | doi = 10.1016/0014-5793(93)81377-C | doi-access = free }}
* {{저널 인용| vauthors = Candelore MR, Deng L, Tota LM, Kelly LJ, Cascieri MA, Strader CD | title = Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant | journal = Endocrinology | volume = 137 | issue = 6 | pages = 2638–41 | year = 1996 | pmid = 8641219 | doi = 10.1210/en.137.6.2638 | doi-access = free }}
* {{저널 인용| vauthors = Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T | title = Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain | url = https://archive.org/details/sim_diabetologia_1996-03_39_3/page/349 | journal = Diabetologia | volume = 39 | issue = 3 | pages = 349–52 | year = 1996 | pmid = 8721782 | doi = 10.1007/BF00418352 }}
* {{저널 인용| vauthors = Higashi K, Ishikawa T, Ito T, Yonemura A, Shige H, Nakamura H | title = Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese | journal = Biochem. Biophys. Res. Commun. | volume = 232 | issue = 3 | pages = 728–30 | year = 1997 | pmid = 9126344 | doi = 10.1006/bbrc.1997.6339 }}
* {{저널 인용| vauthors = Hoffstedt J, Poirier O, Thörne A, Lönnqvist F, Herrmann SM, Cambien F, Arner P | title = Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function | url = https://archive.org/details/sim_diabetes_1999-01_48_1/page/203 | journal = Diabetes | volume = 48 | issue = 1 | pages = 203–5 | year = 1999 | pmid = 9892244 | doi = 10.2337/diabetes.48.1.203 }}
* {{저널 인용| vauthors = Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A | title = Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis | journal = Nat. Genet. | volume = 22 | issue = 3 | pages = 239–47 | year = 1999 | pmid = 10391210 | doi = 10.1038/10297 }}
* {{저널 인용| vauthors = Kimura K, Sasaki N, Asano A, Mizukami J, Kayahashi S, Kawada T, Fushiki T, Morimatsu M, Yoshida T, Saito M | title = Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes | journal = Horm. Metab. Res. | volume = 32 | issue = 3 | pages = 91–6 | year = 2000 | pmid = 10786926 | doi = 10.1055/s-2007-978597 }}
* {{저널 인용| vauthors = Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S | title = Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation | journal = J. Biol. Chem. | volume = 275 | issue = 49 | pages = 38131–4 | year = 2001 | pmid = 11013230 | doi = 10.1074/jbc.C000592200 | doi-access = free }}
* {{저널 인용| vauthors = Russell ST, Hirai K, Tisdale MJ | title = Role of β3-adrenergic receptors in the action of a tumour lipid mobilizing factor | journal = Br. J. Cancer | volume = 86 | issue = 3 | pages = 424–8 | year = 2002 | pmid = 11875710 | pmc = 2375201 | doi = 10.1038/sj.bjc.6600086 }}
{{참고 자료 끝}}

== 외부 링크 ==
* {{웹 인용|url=http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2191|제목=β<sub>3</sub>-adrenoceptor|웹사이트=IUPHAR Database of Receptors and Ion Channels|출판사=International Union of Basic and Clinical Pharmacology|확인날짜=2021-03-25|archive-date=2014-12-30|archive-url=https://web.archive.org/web/20141230175443/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2191|url-status=}}
* {{UCSC gene info|ADRB3}}

[[분류:아드레날린 수용체]]
[[분류:인간 8번 염색체상 유전자]]