{{위키데이터 속성 추적}}
{{유전자 정보}}
'''CCAAT/증폭자 결합 단백질 베타'''(CCAAT/enhancer-binding protein beta)는 인간의 ''CEBPB'' 유전자에 의해 암호화 된 [[단백질]]이다.<ref name="pmid1535333">{{저널 인용|제목=Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)|저널=Genomics|날짜=Jul 1992|권=13|호=2|쪽=293–300|doi=10.1016/0888-7543(92)90245-N|pmc=|pmid=1535333}}</ref><ref name="pmid1840554">{{저널 인용|제목=Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells|저널=Genes Dev|날짜=Oct 1991|권=5|호=9|쪽=1538–52|doi=10.1101/gad.5.9.1538|pmc=|pmid=1840554}}</ref>

== 기능 ==
[[인트론]]이 없는 유전자에 의해 암호화 된 단백질은 특정 DNA 조절 영역에 동종 이량체로서 결합 할 수 있는 bZIP [[전사인자]]이다. 또한 관련 단백질 CEBP-알파, CEBP-델타, CEBP-감마와 함께 이종 이량체를 형성 할 수 있다. 암호화 된 단백질은 면역 및 염증 반응에 관여하는 유전자의 조절에 중요하며, IL-6 유전자의 IL-1 반응 요소 및 몇몇 급성기, [[사이토카인]] 유전자의 조절 영역에 결합하는 것으로 나타났다. 또한 암호화 된 단백질은 [[프로모터]] 및 상류 요소에 결합하여 제 1형 [[콜라겐]] 유전자의 발현을 자극 할 수 있다.<ref>{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1051|제목=Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta|확인날짜=}}</ref>

CEBP-베타는 정상적인 [[대식세포]] 기능, 중요한 [[면역계|면역]] 세포 아형에 중요하다. CEBP-베타를 [[유전자 발현|발현]] 할 수 없는 쥐는 대식세포-매개 근육 복구를 포함하여 [[세포 분화|분화]] 할 수 없고, 이들의 모든 생물학적 기능을 수행할 수 없는 대식세포를 갖는다.<ref name="ruffel_mice">{{저널 인용|제목=A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair|저널=Proc. Natl. Acad. Sci. U.S.A.|연도=2009|권=106|호=41|쪽=17475–80|doi=10.1073/pnas.0908641106|pmc=2762675|pmid=19805133}}</ref> [[역학]] 작업은 혈액의 [[백혈구]]에서 CEBP-베타의 [[유전자 발현|발현]]이 인간의 근력과 긍정적으로 관련되어 있음을 보여 주었고<ref name="harries_cebpb">{{저널 인용|제목=CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength|저널=Aging Cell|연도=2012|권=11|호=2|쪽=262–8|doi=10.1111/j.1474-9726.2011.00782.x|pmc=3486692|pmid=22152057}}</ref>, 근육 기능 유지에 있어 면역계, 특히 대식세포의 중요성을 강조하고 있다.

CEBPB 유전자의 기능은 독립적 인 검증에 기초하여 siRNA 녹다운에 의해 효과적으로 검사 될 수있다.<ref>{{저널 인용|제목=Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments|저널=Molecular Therapy - Nucleic Acids|성=Munkácsy|이름=Gyöngyi|성2=Sztupinszki|이름2=Zsófia|날짜=2016-01-01|권=5|호=9|쪽=e366|언어=영어|doi=10.1038/mtna.2016.66|issn=2162-2531|pmc=5056990|pmid=27673562|성3=Herman|이름3=Péter|성4=Bán|이름4=Bence|성5=Pénzváltó|이름5=Zsófia|성6=Szarvas|이름6=Nóra|성7=Győrffy|이름7=Balázs}}</ref>

== 표적 유전자 ==
CEBPB는 여러 표적 유전자의 발현을 증가시킬 수 있다. 그 중 일부는 preprotachykinin-1 유전자와 같은 신경계에서 특정 역할을 담당하여 물질 P, 뉴로키닌 A<ref name="pmid16771829">{{저널 인용|제목=C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones|저널=J. Neurochem.|날짜=September 2006|권=98|호=5|쪽=1390–9|doi=10.1111/j.1471-4159.2006.03957.x|pmid=16771829}}</ref>, 중요한 [[신경전달물질]]인 [[아세틸콜린]]의 생합성을 담당하는 콜린아세틸트린스퍼레이스를 유발시킨다.<ref name="pmid12393272">{{저널 인용|제목=Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta|저널=Brain Res. Mol. Brain Res.|날짜=October 2002|권=106|호=1–2|쪽=124–35|doi=10.1016/S0169-328X(02)00419-9|pmid=12393272}}</ref> 다른 표적은 [[인터루킨 4]]<ref name="pmid1730090">{{저널 인용|제목=Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6|저널=Blood|날짜=January 1992|권=79|호=2|쪽=460–6|doi=|pmid=1730090}}</ref>, 인터루킨 6<ref name="pmid7594540">{{저널 인용|제목=Nuclear factor-IL6 activates the human IL-4 promoter in T cells|저널=J. Immunol.|날짜=December 1995|권=155|호=11|쪽=5273–9|doi=|pmid=7594540}}</ref>, 인터루킨 5<ref name="pmid10453008">{{저널 인용|제목=A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene|저널=J. Immunol.|날짜=September 1999|권=163|호=5|쪽=2674–80|pmid=10453008}}</ref>, [[종양괴사인자 알파]]와 같은 [[사이토카인]]을 암호화하는 유전자를 포함한다.<ref name="pmid10629048">{{저널 인용|제목=Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins|url=https://archive.org/details/sim_molecular-and-cellular-biology_2000-02_20_3/page/912|저널=Mol. Cell. Biol.|날짜=February 2000|권=20|호=3|쪽=912–8|doi=10.1128/MCB.20.3.912-918.2000|pmc=85208|pmid=10629048}}</ref> 또한 세포에 다약제내성을 부여하는 수송 단백질을 암호화하는 유전자는 CEBPB에 의해 활성화되는 것으로 밝혀졌다. 이러한 유전자에는 ABCC2<ref name="pmid10573531">{{저널 인용|제목=The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells|url=https://archive.org/details/sim_hepatology_1999-12_30_6/page/1507|저널=Hepatology|날짜=December 1999|권=30|호=6|쪽=1507–12|doi=10.1002/hep.510300617|pmid=10573531}}</ref> 및 ABCB1이 포함된다.<ref name="pmid15044620">{{저널 인용|제목=CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells|저널=Mol. Pharmacol.|날짜=April 2004|권=65|호=4|쪽=906–16|doi=10.1124/mol.65.4.906|pmid=15044620}}</ref>

== 상호 작용 ==
CEBPB는 다음과 상호 작용하는 것으로 나타났다. {{Div col}}
* [[CREB1]],<ref name = pmid12773552>{{저널 인용| vauthors = Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB | title = Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta | url = https://archive.org/details/sim_molecular-and-cellular-biology_2003-06_23_12/page/4066 | journal = Mol. Cell. Biol. | volume = 23 | issue = 12 | pages = 4066–82 | pmid = 12773552 | pmc = 156132 | doi = 10.1128/mcb.23.12.4066-4082.2003 | year = 2003 }}</ref>
* [[CRSP3]]<ref name = pmid14759369>{{저널 인용| vauthors = Mo X, Kowenz-Leutz E, Xu H, Leutz A | title = Ras induces mediator complex exchange on C/EBP beta | journal = Mol. Cell | volume = 13 | issue = 2 | pages = 241–50 | pmid = 14759369 | doi = 10.1016/s1097-2765(03)00521-5 | date=January 2004}}</ref>
* [[DNA damage-inducible transcript 3]],<ref name = pmid12706815>{{저널 인용| vauthors = Hattori T, Ohoka N, Hayashi H, Onozaki K | title = C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform | journal = FEBS Lett. | volume = 541 | issue = 1–3 | pages = 33–9 | pmid = 12706815 | doi = 10.1016/s0014-5793(03)00283-7 | date=April 2003}}</ref><ref name = pmid8662954>{{저널 인용| vauthors = Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ | title = Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14285–9 | pmid = 8662954 | doi = 10.1074/jbc.271.24.14285 | date=June 1996}}</ref>
* [[EP300]],<ref name = pmid9343424>{{저널 인용| vauthors = Mink S, Haenig B, Klempnauer KH | title = Interaction and functional collaboration of p300 and C/EBPbeta | url = https://archive.org/details/sim_molecular-and-cellular-biology_1997-11_17_11/page/6609 | journal = Mol. Cell. Biol. | volume = 17 | issue = 11 | pages = 6609–17 | date = November 1997 | pmid = 9343424 | pmc = 232514 | doi =  10.1128/mcb.17.11.6609}}</ref>
* [[Estrogen receptor alpha]],<ref name = pmid9817600/><ref name = pmid7651415>{{저널 인용| vauthors = Stein B, Yang MX | title = Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta | url = https://archive.org/details/sim_molecular-and-cellular-biology_1995-09_15_9/page/4971 | journal = Mol. Cell. Biol. | volume = 15 | issue = 9 | pages = 4971–9 | date = September 1995 | pmid = 7651415 | pmc = 230744 | doi =  10.1128/mcb.15.9.4971}}</ref>
* [[Glucocorticoid receptor]],<ref name = pmid9817600>{{저널 인용| vauthors = Boruk M, Savory JG, Haché RJ | title = AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor | journal = Mol. Endocrinol. | volume = 12 | issue = 11 | pages = 1749–63 | pmid = 9817600 | doi = 10.1210/mend.12.11.0191 | date=November 1998}}</ref>
* [[HMGA1]],<ref name = pmid12665574/>
* [[HSF1]],<ref name = pmid11801594>{{저널 인용| vauthors = Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK | title = Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6 | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 11802–10 | pmid = 11801594 | doi = 10.1074/jbc.M109296200 | date=April 2002}}</ref>
* [[Nucleolar phosphoprotein p130]],<ref name = pmid9553145>{{저널 인용| vauthors = Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC | title = Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation | journal = J. Biol. Chem. | volume = 273 | issue = 17 | pages = 10784–91 | pmid = 9553145 | doi = 10.1074/jbc.273.17.10784 | date=April 1998}}</ref>
* [[RELA]],<ref name = pmid12707271>{{저널 인용| vauthors = Weber M, Sydlik C, Quirling M, Nothdurfter C, Zwergal A, Heiss P, Bell S, Neumeier D, Ziegler-Heitbrock HW, Brand K | title = Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta | journal = J. Biol. Chem. | volume = 278 | issue = 26 | pages = 23586–93 | pmid = 12707271 | doi = 10.1074/jbc.M211646200 | date=June 2003}}</ref><ref name = pmid9570146>{{저널 인용| vauthors = Xia C, Cheshire JK, Patel H, Woo P | title = Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes | url = https://archive.org/details/sim_international-journal-of-biochemistry-cell-biology_1997-12_29_12/page/1525 | journal = Int. J. Biochem. Cell Biol. | volume = 29 | issue = 12 | pages = 1525–39 | pmid = 9570146 | doi = 10.1016/s1357-2725(97)00083-6 | date=December 1997}}</ref>
* [[Serum response factor]],<ref name = pmid10318842>{{저널 인용| vauthors = Hanlon M, Sealy L | title = Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 14224–8 | pmid = 10318842 | doi = 10.1074/jbc.274.20.14224 | date=May 1999}}</ref><ref name = pmid9032301>{{저널 인용| vauthors = Sealy L, Malone D, Pawlak M | title = Regulation of the cfos serum response element by C/EBPbeta | url = https://archive.org/details/sim_molecular-and-cellular-biology_1997-03_17_3/page/1744 | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1744–55 | date = March 1997 | pmid = 9032301 | pmc = 231899 | doi =  10.1128/mcb.17.3.1744}}</ref>
* [[SMARCA2]],<ref name = pmid10619021>{{저널 인용| vauthors = Kowenz-Leutz E, Leutz A | title = A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes | journal = Mol. Cell | volume = 4 | issue = 5 | pages = 735–43 | pmid = 10619021 | doi = 10.1016/s1097-2765(00)80384-6 | date=November 1999}}</ref>
* [[Sp1 transcription factor]],<ref name = pmid12665574>{{저널 인용| vauthors = Foti D, Iuliano R, Chiefari E, Brunetti A | title = A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription | url = https://archive.org/details/sim_molecular-and-cellular-biology_2003-04_23_8/page/2720 | journal = Mol. Cell. Biol. | volume = 23 | issue = 8 | pages = 2720–32 | pmid = 12665574 | pmc = 152545 | doi = 10.1128/mcb.23.8.2720-2732.2003 | year = 2003 }}</ref><ref name = pmid12847250>{{저널 인용| vauthors = Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC | title = Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages | journal = J. Immunol. | volume = 171 | issue = 2 | pages = 821–8 | pmid = 12847250 | doi = 10.4049/jimmunol.171.2.821 | date=July 2003}}</ref>
* [[TRIM28]],<ref name = pmid11711437>{{저널 인용| vauthors = Rooney JW, Calame KL | title = TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937 | journal = Genes Dev. | volume = 15 | issue = 22 | pages = 3023–38 | pmid = 11711437 | pmc = 312827 | doi = 10.1101/gad.937201 | year = 2001 }}</ref><ref name = pmid9742105>{{저널 인용| vauthors = Chang CJ, Chen YL, Lee SC | title = Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression | url = https://archive.org/details/sim_molecular-and-cellular-biology_1998-10_18_10/page/5880 | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5880–7 | date = October 1998 | pmid = 9742105 | pmc = 109174 | doi =  10.1128/mcb.18.10.5880}}</ref>  and
* [[Zif268]].<ref name = pmid12947119>{{저널 인용| vauthors = Zhang F, Lin M, Abidi P, Thiel G, Liu J | title = Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44246–54 | pmid = 12947119 | doi = 10.1074/jbc.M305564200 | date=November 2003}}</ref>
{{Div col end}}

== 각주 ==
{{각주}}

[[분류:전사인자]]
[[분류:인간 20번 염색체상 유전자]]