{{위키데이터 속성 추적}}
{{유전자 정보}}
'''클래스 E 기본 나선-루프-나선 단백질 40'''(BHLHB2)은 인간에서 ''BHLHE40'' [[유전자]]에 의해 암호화 된 [[단백질]]이다.<ref name="pmid9240428">{{저널 인용|제목=Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes|저널=Biochemical and Biophysical Research Communications|날짜=Jul 1997|권=236|호=2|쪽=294–8|doi=10.1006/bbrc.1997.6960|pmc=|pmid=9240428}}</ref><ref name="pmid10449910">{{저널 인용|제목=Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization|저널=Cytogenetics and Cell Genetics|날짜=Oct 1999|권=85|호=3–4|쪽=254–5|doi=10.1159/000015305|pmc=|pmid=10449910}}</ref><ref name="pmid18557763">{{저널 인용|제목=Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation|저널=Differentiation; Research in Biological Diversity|날짜=Nov 2008|권=76|호=9|쪽=1006–22|doi=10.1111/j.1432-0436.2008.00285.x|pmc=5728086|pmid=18557763}}</ref><ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553|제목=Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2|확인날짜=}}</ref>

== 기능 ==
DEC1은 다양한 조직에서 발현된 기본 나선-루프-나선 단백질을 암호화한다. 연골 세포에서의 발현은 Bt2cAMP의 첨가에 반응한다. 분화된 [[배아]] [[연골]] 세포 발현 유전자 1은 세포 분화의 조절에 관여하는 것으로 여겨진다.<ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553|제목=Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2|확인날짜=}}</ref>

== 각주 ==
{{각주}}

== 추가 자료 ==
{{참고 자료 시작|2}}
* {{저널 인용|제목=Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2|저널=Journal of Biochemistry|날짜=Mar 2001|권=129|호=3|쪽=391–6|doi=10.1093/oxfordjournals.jbchem.a002869|pmid=11226878}}
* {{저널 인용|제목=Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway|저널=The Journal of Biological Chemistry|날짜=May 2001|권=276|호=18|쪽=15306–15|doi=10.1074/jbc.M010516200|pmid=11278694}}
* {{저널 인용|제목=Defective T cell activation and autoimmune disorder in Stra13-deficient mice|저널=Nature Immunology|날짜=Nov 2001|권=2|호=11|쪽=1040–7|doi=10.1038/ni721|pmid=11668339}}
* {{저널 인용|제목=Identification of genes differentially induced by hypoxia in pancreatic cancer cells|저널=Biochemical and Biophysical Research Communications|날짜=Nov 2001|권=288|호=4|쪽=882–6|doi=10.1006/bbrc.2001.5867|pmid=11688991}}
* {{저널 인용|제목=Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation|저널=The Biochemical Journal|날짜=Oct 2002|권=367|호=Pt 2|쪽=413–22|doi=10.1042/BJ20020514|pmc=1222902|pmid=12119049}}
* {{저널 인용|제목=Stra13 homodimers repress transcription through class B E-box elements|저널=The Journal of Biological Chemistry|날짜=Nov 2002|권=277|호=48|쪽=46544–51|doi=10.1074/jbc.M111652200|pmid=12297495}}
* {{저널 인용|제목=Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes|저널=The Journal of Biological Chemistry|날짜=Dec 2002|권=277|호=49|쪽=47014–21|doi=10.1074/jbc.M204938200|pmid=12354771}}
* {{저널 인용|제목=Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages|저널=The Journal of Biological Chemistry|날짜=Dec 2002|권=277|호=51|쪽=50112–20|doi=10.1074/jbc.M206771200|pmid=12384505}}
* {{저널 인용|제목=Dec1 and Dec2 are regulators of the mammalian molecular clock|저널=Nature|날짜=Oct 2002|권=419|호=6909|쪽=841–4|doi=10.1038/nature01123|pmid=12397359}}
* {{저널 인용|제목=DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter|저널=The Journal of Biological Chemistry|날짜=May 2003|권=278|호=19|쪽=16899–907|doi=10.1074/jbc.M300596200|pmid=12624110}}
* {{저널 인용|제목=DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer|url=https://archive.org/details/sim_journal-of-pathology_2003-06_200_2/page/222|저널=The Journal of Pathology|날짜=Jun 2003|권=200|호=2|쪽=222–8|doi=10.1002/path.1330|pmid=12754744}}
* {{저널 인용|제목=STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets|저널=Journal of Molecular Biology|날짜=Jul 2004|권=340|호=4|쪽=641–53|doi=10.1016/j.jmb.2004.05.025|pmid=15223310}}
* {{저널 인용|제목=Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1|저널=European Journal of Biochemistry / FEBS|날짜=Nov 2004|권=271|호=22|쪽=4409–19|doi=10.1111/j.1432-1033.2004.04379.x|pmid=15560782}}
* {{저널 인용|제목=Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins|저널=Cellular and Molecular Life Sciences|url=https://zenodo.org/record/1232585|날짜=Feb 2005|권=62|호=4|쪽=471–84|doi=10.1007/s00018-004-4423-2|pmid=15719173}}
* {{저널 인용|제목=STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker|url=https://archive.org/details/sim_journal-of-medical-genetics_2005-07_42_7/page/565|저널=Journal of Medical Genetics|날짜=Jul 2005|권=42|호=7|쪽=565–76|doi=10.1136/jmg.2004.029835|pmc=1736099|pmid=15994878}}
* {{저널 인용|제목=A human protein-protein interaction network: a resource for annotating the proteome|저널=Cell|날짜=Sep 2005|권=122|호=6|쪽=957–68|doi=10.1016/j.cell.2005.08.029|pmid=16169070}}
{{참고 자료 끝}}

[[분류:전사인자]]
[[분류:인간 3번 염색체상 유전자]]