{{위키데이터 속성 추적}}
{{chembox
| Verifiedfields = changed
| verifiedrevid = 451629340
| ImageFile = Beta-D-Fructose-2,6-bisphosphat.svg
| ImageSize = 150px
| ImageCaption = 
| IUPACName = 2,6-di-''O''-phosphono-β-<small>D</small>-fructofuranose
| OtherNames = 
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 94762
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/t3-,4-,5+,6+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = YXWOAJXNVLXPMU-ZXXMMSQZSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 79082-92-1
| PubChem = 105021
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 28602
| SMILES = C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)OP(=O)(O)O)O)O)OP(=O)(O)O
| MeSHName = fructose+2,6-bisphosphate
  }}
|Section2={{Chembox Properties
| C=6
| H=14
| O=12
| P=2
| Appearance = 
| Density = 
| MeltingPt = 
| BoilingPt = 
  }}
|Section3={{Chembox Hazards

| MainHazards = 
| FlashPt = 
| AutoignitionPt = 
  }}
}}

'''과당 2,6-이중인산'''({{llang|en|Fructose 2,6-bisphosphate, '''F2,6BP'''}})은 [[효소]]인 [[포스포프럭토키네이스-1]](PFK-1) 및 [[과당 1,6-비스포스파테이스]](FBPase-1)의 활성에 [[알로스테릭 조절|알로스테릭]]하게 영향을 미쳐 [[해당과정]]과 [[포도당신생합성]]을 조절하는 대사산물이다.<ref>{{저널 인용|last1=Alfarouk |first1=Khalid O. |last2=Verduzco |first2=Daniel |last3=Rauch |first3=Cyril |last4=Muddathir |first4=Abdel Khalig |last5=Bashir |first5=Adil H. H. |last6=Elhassan |first6=Gamal O. |last7=Ibrahim |first7=Muntaser E. |last8=Orozco |first8=Julian David Polo |last9=Cardone |first9=Rosa Angela |last10=Reshkin |first10=Stephan J. |last11=Harguindey |first11=Salvador |title=Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question |journal=Oncoscience |date=18 December 2014 |volume=1 |issue=12 |pages=777 |doi=10.18632/oncoscience.109|doi-access=free }}</ref> 과당 2,6-이중인산 자체는 이기능성 효소인 [[포스포프럭토키네이스-2]]/[[과당 2,6-비스포스파테이스]](PFK-2/FBPase-2)에 의해 생성되고 분해된다.<ref name="pmid16860376">{{저널 인용|vauthors=Wu C, Khan SA, Peng LJ, Lange AJ | title = Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes | journal = Adv. Enzyme Regul. | volume = 46 | issue = 1| pages = 72–88 | year = 2006 | pmid = 16860376 | doi = 10.1016/j.advenzreg.2006.01.010 | url = | issn = }}</ref>

과당 2,6-이중인산의 생성은 탈인산화된 PFK-2와 FBPase-2를 둘 다 포함하고 있는 이기능성 효소에 의해 수행되며, PFK-2 부분이 [[아데노신 삼인산|ATP]]를 사용하여 [[과당 6-인산]]을 [[인산화]]시킨다. 과당 2,6-이중인산의 분해는 이기능성 효소의 인산화에 의해 촉매되며, FBPase-2가 과당 2,6-이중인산을 탈인산화시켜 과당 6-인산과 무기 인산(P<sub>i</sub>)를 생성한다.<ref name="kurland">{{저널 인용|vauthors=Kurland IJ, Pilkis SJ | title = Covalent control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: insights into autoregulation of a bifunctional enzyme | journal = Protein Sci. | volume = 4 | issue = 6 | pages = 1023–37 |date=June 1995 | pmid = 7549867 | pmc = 2143155 | doi = 10.1002/pro.5560040601 | url = | issn = }}</ref>

== 같이 보기 ==
{{위키공용분류}}
* [[포스포프럭토키네이스-2]]
* [[과당 1,6-이중인산]]

== 각주 ==
{{각주}}

{{해당과정}}

[[분류:단당류 유도체]]
[[분류:유기 인산염]]
[[분류:해당]]