{{위키데이터 속성 추적}}
{{Chembox
| ImageFile = 2-Hydroxyisobutyric acid.svg
| ImageSize = 180
| ImageAlt = 
| IUPACName = 
| OtherNames = α-hydroxyisobutyric acid,<br>2-hydroxyisobutanoic acid,<br>α-hydroxyisobutanoic acid,<br>2-hydroxy-2-methyl propanoic acid,<br>2-hydroxy-2-methyl propionic acid,<br>2-methyllactic acid,<br>2-methylglycolic acid,<br>acetonic acid,<br>hydroxydimethylacetic acid
|Section1={{Chembox Identifiers
| CASNo = 594-61-6
| CASNo_Ref = {{Cascite|correct|CAS}}
| Beilstein = 1744739
| ChEBI = 50129
| ChEMBL = 1345148
| ChemSpiderID = 11181
| EC_number = 209-848-8
| PubChem = 11671
| UNII = DMW250U2HF
| StdInChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)
| StdInChIKey = BWLBGMIXKSTLSX-UHFFFAOYSA-N
| SMILES = CC(C)(C(=O)O)O
 }}
|Section2={{Chembox Properties
| C=4|H=8|O=3
| MolarMass =
| Appearance = 흰색 고체
| Density = 1.23 g/cm<sup>3</sup><ref>W.P.J.Gaykema; J.A.Kanters; G.Roelofsen (1978), ''Cryst. Struct. Commun.'', 47: 463</ref>
| MeltingPtC = 82.5
| BoilingPtC = 212
| Solubility = }}
}}
'''2-하이드록시아이소뷰티르산'''({{llang|en|2-hydroxyisobutyric acid}})은 [[화학식]]이 {{chem2|(CH3)2C(OH)CO2H}}인 [[유기 화합물]]이다. 2-하이드록시아이소뷰티르산은 흰색 고체로 [[하이드록시카복실산]]으로 분류된다. 2-하이드록시아이소뷰티르산은 [[폴리에스터]]의 자연 발생 전구체로 간주되어 왔다.<ref>{{저널 인용|doi=10.1007/s11157-016-9415-9|title=Biosynthesis of Polyesters and Polyamide Building Blocks Using Microbial Fermentation and Biotransformation |year=2016 |last1=Bhatia |first1=Shashi Kant |last2=Bhatia |first2=Ravi Kant |last3=Yang |first3=Yung-Hun |journal=Reviews in Environmental Science and Bio/Technology |volume=15 |issue=4 |pages=639–663 |s2cid=88561532 }}</ref> 2-하이드록시아이소뷰티르산은 [[젖산]]({{chem2|CH3CH(OH)CO2H}})과 밀접하게 관련되어 있다.<ref>{{Ullmann |doi=10.1002/14356007.a13_507|title=Hydroxycarboxylic Acids, Aliphatic |year=2000 |last1=Miltenberger |first1=Karlheinz |isbn=3527306730}}</ref>

== 생성 ==
2-하이드록시아이소뷰티릴 조효소 A(CoA) 뮤테이스는 3-하이드록시뷰티릴 조효소 A를 2-하이드록시아이소뷰티릴 조효소 A로 [[이성질화]]한다. 2-하이드록시아이소뷰티릴 조효소 A를 가수분해하면 2-하이드록시아이소뷰티르산이 생성된다.<ref>{{저널 인용|doi=10.1128/AEM.02622-16|title=Production of 2-Hydroxyisobutyric Acid from Methanol by ''Methylobacterium extorquens'' AM1 Expressing ( R )-3-Hydroxybutyryl Coenzyme A-Isomerizing Enzymes |year=2017 |last1=Rohde |first1=Maria-Teresa |last2=Tischer |first2=Sylvi |last3=Harms |first3=Hauke |last4=Rohwerder |first4=Thore |journal=Applied and Environmental Microbiology |volume=83 |issue=3 |pmid=27836853 |pmc=5244315 |bibcode=2017ApEnM..83E2622R }}</ref>

2-하이드록시아이소뷰티르산과 [[리신]] [[잔기]]의 ε-아미노기로부터 형성된 [[아마이드]]는 [[번역 후 변형]]의 일종이다.<ref>{{저널 인용|doi=10.1038/nchembio.1497|title=Lysine 2-Hydroxyisobutyrylation is a Widely Distributed Active Histone Mark |year=2014 |last1=Dai |first1=Lunzhi |last2=Peng |first2=Chao |last3=Montellier |first3=Emilie |last4=Lu |first4=Zhike |last5=Chen |first5=Yue |last6=Ishii |first6=Haruhiko |last7=Debernardi |first7=Alexandra |last8=Buchou |first8=Thierry |last9=Rousseaux |first9=Sophie |last10=Jin |first10=Fulai |last11=Sabari |first11=Benjamin R. |last12=Deng |first12=Zhiyou |last13=Allis |first13=C David |last14=Ren |first14=Bing |last15=Khochbin |first15=Saadi |last16=Zhao |first16=Yingming |journal=Nature Chemical Biology |volume=10 |issue=5 |pages=365–370 |pmid=24681537 }}</ref><ref>{{저널 인용|doi=10.1021/pr100899x|title=Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine |year=2011 |last1=Carrola |first1=Joana |last2=Rocha |first2=CláUdia M. |last3=Barros |first3=António S. |last4=Gil |first4=Ana M. |last5=Goodfellow |first5=Brian J. |last6=Carreira |first6=Isabel M. |last7=Bernardo |first7=João |last8=Gomes |first8=Ana |last9=Sousa |first9=Vitor |last10=Carvalho |first10=Lina |last11=Duarte |first11=Iola F. |journal=Journal of Proteome Research |volume=10 |issue=1 |pages=221–230 |pmid=21058631 }}</ref>

[[에틸 메타크릴레이트]](산업적으로 중요한 [[단량체]]이며 [[메타크릴산]]의 [[에스터]])는 겉보기 탈수 반응에서 2-하이드록시아이소뷰티르산의 에틸 에스터를 [[오염화 인]]으로 처리하여 처음으로 얻었다.<ref>{{저널 인용|journal=Justus Liebigs Annalen der Chemie|volume= 136|page= 12|title=Untersuchungen über Säuren aus der Acrylsäure-Reihe; 1) Umwandlung der Säuren aus der Milchsäure-Reihe in die der Acrylsäure-Reihe|author=E. Frankland, B. F. Duppa|year=1865|doi=10.1002/jlac.18651360102|url= https://zenodo.org/record/1427247}}</ref>

== 같이 보기 ==
* [[3-하이드록시아이소뷰티르산]]

== 각주 ==
{{각주}}

[[분류:알파-하이드록시산]]