{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 457127811
| IUPAC_name = 22,23-dihydroavermectin B<sub>1a</sub> + 22,23-dihydroavermectin B<sub>1b</sub>
| image = Ivermectin skeletal.svg
| width = 300

<!--Clinical data-->
| tradename = Stromectol, Soolantra cream
| Drugs.com = {{drugs.com|monograph|ivermectin}} ([[antiparasitic]])<br />{{Drugs.com|pro|soolantra-cream}} ([[rosacea]])
| MedlinePlus = a607069
| pregnancy_AU = B3
| pregnancy_US = C
| legal_US = Rx-only
| routes_of_administration = by mouth, topical

<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound = 93%
| metabolism = Liver ([[CYP450]])
| elimination_half-life = 18 hours
| excretion = Feces; <1% urine

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 70288-86-7
| CAS_supplemental = {{CAS|71827-03-7}}
| ATC_prefix = D11
| ATC_suffix = AX22
| ATC_supplemental = {{ATC|P02|CF01}} {{ATCvet|P54|AA01}} {{ATCvet|S02|QA03}}
| PubChem = 9812710
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00602
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 7988461
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 8883YP2R6D
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00804
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 341047
| PDB_ligand = IVM

<!--Chemical data-->
| chemical_formula = {{Chem | C|48 | H|74 | O|14}} {{nowrap|1=(22,23-dihydroavermectin&nbsp;B<sub>1a</sub>)}}<br />{{Chem | C|47 | H|72 | O|14}} {{nowrap|1=(22,23-dihydroavermectin&nbsp;B<sub>1b</sub>)}}
| molecular_weight = 875.10 g/mol
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SPBDXSGPUHCETR-JFUDTMANSA-N
| smiles = CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)O[C@@H]1C(C)C
}}

'''이버멕틴'''(Ivermectin)은 다양한 [[기생충]]을 구제하는 데 쓰는 [[구충제]] 성분으로,<ref name=Sau2015>{{서적 인용|title=Saunders Handbook of Veterinary Drugs: Small and Large Animal|date=2015|publisher=Elsevier Health Sciences|isbn=978-0-323-24486-2|page=420|edition=4|url=https://books.google.co.jp/books?id=SJvmCgAAQBAJ&pg=PA420|url-status=live|archiveurl=https://web.archive.org/web/20160131142826/https://books.google.co.jp/books?id=SJvmCgAAQBAJ&pg=PA420|archivedate=January 31, 2016|df=mdy-all}}</ref> [[이 (동물)|이]],<ref name=AHFS2016 /> [[옴 (질병)|옴]],<ref>{{저널 인용|last1=Panahi|first1=Y|last2=Poursaleh|first2=Z|last3=Goldust|first3=M|title=The efficacy of topical and oral ivermectin in the treatment of human scabies.|journal=Annals of Parasitology|date=2015|volume=61|issue=1|pages=11–6|pmid=25911032}}</ref> [[강변 실명증]],<ref>{{서적 인용|last1=Sneader|first1=Walter|title=Drug Discovery a History.|date=2005|publisher=John Wiley & Sons|location=Chichester|isbn=978-0-470-01552-0|page=333|url=https://books.google.co.jp/books?id=jglFsz5EJR8C&pg=PA333|url-status=live|archiveurl=https://web.archive.org/web/20160131141138/https://books.google.co.jp/books?id=jglFsz5EJR8C&pg=PA333|archivedate=January 31, 2016|df=mdy-all}}</ref> [[분선충증]],<ref name=Ric2014>{{서적 인용|last1=Hamilton|first1=Richard J.|title=Tarascon pocket pharmacopoeia : 2014 deluxe lab-pocket edition|date=2014|publisher=Jones & Bartlett Learning|location=Sudbury|isbn=978-1-284-05399-9|page=422|edition=15th|url=https://books.google.co.jp/books?id=BwqEAgAAQBAJ&pg=PA422|url-status=live|archiveurl=https://web.archive.org/web/20160131114409/https://books.google.co.jp/books?id=BwqEAgAAQBAJ&pg=PA422|archivedate=January 31, 2016|df=mdy-all}}</ref> [[림프사상충증]] 및 기타 기생충 질병을 치료할 수 있다.<ref name=Meh2008>{{서적 인용|last1=Mehlhorn|first1=Heinz|title=Encyclopedia of parasitology|date=2008|publisher=Springer|location=Berlin|isbn=978-3-540-48994-8|page=646|edition=3rd|url=https://books.google.co.jp/books?id=Jpg1ysgVn-AC&pg=PA646|url-status=live|archiveurl=https://web.archive.org/web/20160131155507/https://books.google.co.jp/books?id=Jpg1ysgVn-AC&pg=PA646|archivedate=January 31, 2016|df=mdy-all}}</ref> [[피부]]로 흡수하거나 섭취하여 복용하는 것이 가능하지만 [[안구]]와의 접촉은 피해야 한다. 또한 [[적안]], 피부건조증, 화상 등의 부작용이 발생한다.<ref name=AHFS2016>{{웹 인용|title=Ivermectin|url=https://www.drugs.com/monograph/ivermectin.html|publisher=The American Society of Health-System Pharmacists|accessdate=16 January 2016|url-status=live|archiveurl=https://web.archive.org/web/20160103191914/http://www.drugs.com/monograph/ivermectin.html|archivedate=January 3, 2016|df=mdy-all}}</ref>

== 각주 ==
{{각주}}

{{전거 통제}}

[[분류:살응애제]]
[[분류:항기생충제]]
[[분류:살충제]]
[[분류:GABAA 양성 알로스테릭 조절자]]
[[분류:글라이신 수용체 작용제]]
[[분류:니코틴 작용제]]
[[분류:마크롤라이드]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:염소 통로 개방제]]