{{위키데이터 속성 추적}}
{{chembox
| verifiedrevid = 
| ImageFile = 3,5-Diiodothyronine.svg
| ImageSize = 200px
| ImageAlt = 
| ImageFile1 = 
| ImageSize1 = 
| ImageAlt1 = 
| IUPACName = 2-Amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid
| OtherNames = 
| Section1 = {{Chembox Identifiers
| IUPHAR_ligand = 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 110252
| InChI = 1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)
| InChIKey = ZHSOTLOTTDYIIK-UHFFFAOYSA-N
| SMILES1 = C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(C(=O)O)N)I
| StdInChI_Ref = 
| StdInChI = 
| StdInChIKey_Ref = 
| StdInChIKey = 
| CASNo = 
| PubChem = 123675 
| ChEBI = 
| SMILES = C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(C(=O)O)N)I
| MeSHName = 3,5-diiodothyronine
  }}
| Section2 = {{Chembox Properties
| C=15 | H=13 | I=2 | N=1 | O=4
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| BoilingPt = 
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| Section3 = {{Chembox Hazards
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'''3,5-다이아이오도티로닌'''({{llang|en|3,5-diiodothyronine}}, '''3,5-T<sub>2</sub>''')은 아이오도티로닌 계열의 활성형의 [[갑상샘 호르몬]]이다. 내부 고리의 3번 위치와 5번 위치에 각각 [[아이오딘]] 원자가 위치해 있다.

== 생물학적 효과 ==
3,5-다이아이오도티로닌은 활성형의 갑상샘 호르몬이다. 3,5-다이아이오도티로닌은 갑상샘 호르몬에 대한 [[갑상샘 호르몬 수용체 베타]](TR-β)를 자극하여, 에너지 소비를 증가시킨다.<ref>{{저널 인용| vauthors = Goglia F | title = The effects of 3,5-diiodothyronine on energy balance | journal = Frontiers in Physiology | volume = 5 | pages = 528 | pmid = 25628573 | doi = 10.3389/fphys.2014.00528 | year=2014 | pmc=4292545}}</ref><ref>{{저널 인용| vauthors = Lombardi A, Senese R, De Matteis R, Busiello RA, Cioffi F, Goglia F, Lanni A | title = 3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats | journal = PLOS ONE | volume = 10 | issue = 2 | pages = e0116498 | pmid = 25658324 | doi = 10.1371/journal.pone.0116498 | year=2015 | pmc=4319745| bibcode = 2015PLoSO..1016498L }}</ref> 3,5-다이아이오도티로닌은 [[심근]] 조직 및 [[뇌하수체]]에 작용성 효과(갑상샘 호르몬의 효과와 유사한 효과)를 가지며, 이는 3,5-다이아이오도티로닌이 [[갑상샘 자극 호르몬]](TSH)의 방출을 억제하도록 한다.<ref>{{저널 인용| vauthors = Padron AS, Neto RA, Pantaleão TU, de Souza dos Santos MC, Araujo RL, de Andrade BM, da Silva Leandro M, de Castro JP, Ferreira AC, de Carvalho DP | title = Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues | journal = The Journal of Endocrinology | volume = 221 | issue = 3 | pages = 415–27 | date = Jun 2014 | pmid = 24692290 | doi = 10.1530/JOE-13-0502 | pmc=4045230}}</ref><ref>{{저널 인용| vauthors = Jonas W, Lietzow J, Wohlgemuth F, Hoefig CS, Wiedmer P, Schweizer U, Köhrle J, Schürmann A | title = 3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice | journal = Endocrinology | volume = 156 | issue = 1 | pages = 389–99 | date = Jan 2015 | pmid = 25322465 | doi = 10.1210/en.2014-1604 | pmc=4272399}}</ref> 3,5-다이아이오도티로닌은 [[전자전달계]]의 복합체 IV 인 [[사이토크롬 c 산화효소]]의 [[다른 자리 입체성 조절]] 인자이다. 3,5-다이아이오도티로닌은 사이토크롬 c 산화효소의 다른 자리 입체성 조절 저해제인 [[아데노신 삼인산]](ATP)이 사이토크롬 c 산화효소와 상호작용하는 것을 방해함으로써 사이토크롬 c 산화효소의 활성을 증가시킨다.<ref>{{저널 인용| author = Arnold S. | author2 = Goglia F. | author3 = Kadenbach B.| title = 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.|journal = Eur. J. Biochem. | volume = 252 | pages = 325–330 | year = 1998 | issue = 2 | pmid = 9523704 | doi=10.1046/j.1432-1327.1998.2520325.x}}</ref>

== 임상적 중요성 ==
[[정상갑상샘 질환 증후군]]에서 3,5-다이아이오도티로닌의 농도가 증가한다.<ref>{{저널 인용| vauthors = Pinna G, Meinhold H, Hiedra L, Thoma R, Hoell T, Gräf KJ, Stoltenburg-Didinger G, Eravci M, Prengel H, Brödel O, Finke R, Baumgartner A | title = Elevated 3,5-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 82 | issue = 5 | pages = 1535–42 | date = May 1997 | pmid = 9141546 | doi = 10.1210/jcem.82.5.3939}}</ref><ref name="dietrich2015">{{저널 인용| vauthors = Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A, Klein HH, Mügge A, Köhrle J, Rijntjes E, Lehmphul I | title = Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling | journal = European Thyroid Journal | volume = 4 | issue = 2 | pages = 129–37 | date = Jun 2015 | pmid = 26279999 | doi = 10.1159/000381543 | pmc=4521060}}</ref><ref>{{저널 인용|last1=Langouche|first1=L|last2=Lehmphul|first2=I|last3=Perre|first3=SV|last4=Köhrle|first4=J|last5=Van den Berghe|first5=G|title=Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study.|journal=Thyroid|date=December 2016|volume=26|issue=12|pages=1674–1680|pmid=27676423|doi=10.1089/thy.2016.0214|url=https://lirias.kuleuven.be/handle/123456789/551508}}{{깨진 링크|url=https://lirias.kuleuven.be/handle/123456789/551508 }}</ref><ref name = "Chatzitomaris_2017">{{저널 인용|last1=Chatzitomaris|first1=Apostolos|last2=Hoermann|first2=Rudolf|last3=Midgley|first3=John E.|last4=Hering|first4=Steffen|last5=Urban|first5=Aline|last6=Dietrich|first6=Barbara|last7=Abood|first7=Assjana|last8=Klein|first8=Harald H.|last9=Dietrich|first9=Johannes W.|title=Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming|journal=Frontiers in Endocrinology|date=20 July 2017|volume=8|pages=163|pmid=28775711|pmc=5517413|doi=10.3389/fendo.2017.00163}}</ref> 이것은 정상갑상샘 질환 증후군 환자를 갑상샘 호르몬 대체 요법으로 치료하지 못하는 이유를 설명할 수 있게 해준다.<ref name="dietrich2015"/>

== 같이 보기 ==
* [[3,3'-다이아이오도티로닌]]

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{MeSH name|3,5-diiodothyronine}}

{{갑상샘 호르몬 대사 중간생성물들}}

[[분류:아이오딘화 티로신 유도체]]
[[분류:갑상샘]]
[[분류:사람의 호르몬]]
[[분류:갑상샘 호르몬]]
[[분류:시상하부-뇌하수체-갑상샘 축 호르몬]]