{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 437170931
| IUPAC_name = 3-Diethylamino-1-[2-(trifluoromethyl)phenothiazin-10-yl]-propan-1-one
| image = Fluacizine.svg
| alt = Skeletal formula of fluacizine
| width = 250px
| image2 = Fluacizine 3D spacefill.png
| alt2 = Space-filling model of the fluacizine molecule
| width2 = 200px

<!--Clinical data-->
| tradename = Phtorazisin
| pregnancy_category = 
| legal_status = Rx-only
| routes_of_administration = [[Oral administration|Oral]], [[intramuscular injection]]

<!--Pharmacokinetic data-->
| bioavailability = 
| metabolism = 
| elimination_half-life = 
| excretion = 

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 30223-48-4
| CAS_supplemental = <br />27312-93-2 ([[hydrochloride]])
| ATC_prefix = None
| ATC_suffix = 
| PubChem = 161562
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 141910
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = E2M3325B1R
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 92281
| synonyms = Fluoracizine; Fluoracyzine; Fluoracisine; Ftoracizin; Ftoracizine; Phthoracizin<ref name="Elks2014" /><ref name="MerckIndex2001" />

<!--Chemical data-->
| C=20 | H=21 | F=3 | N=2 | O=1 | S=1
| SMILES = FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)C(=O)CCN(CC)CC
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C20H21F3N2OS/c1-3-24(4-2)12-11-19(26)25-15-7-5-6-8-17(15)27-18-10-9-14(13-16(18)25)20(21,22)23/h5-10,13H,3-4,11-12H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VHEOUJNDDFHPGJ-UHFFFAOYSA-N
}}
'''플루아시진''' (fluacizine)은 '''프토라지신'''(Phtorazisin)의 상표명으로 [[러시아]]에서 판매되기도 하고 있는 [[페노티아진]] (phenothiazine) 계열의 [[삼환계 항우울제]] (TCA)이다.<ref name="Elks2014">{{서적 인용|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA555|제목=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|성=J. Elks|날짜=14 November 2014|출판사=Springer|쪽=555–|isbn=978-1-4757-2085-3}}</ref><ref name="MerckIndex2001">{{서적 인용|url=https://archive.org/details/merckindexency00onei|제목=The Merck index: an encyclopedia of chemicals, drugs, and biologicals|성=O'Neil, Maryadele J.|연도=2001|출판사=Merck Research Laboratories|위치=Rahway, NJ|isbn=0-911910-13-1}}</ref><ref name="Zakusov2013">{{서적 인용|url=https://books.google.com/books?id=lrsgBQAAQBAJ&pg=PA190|제목=Pharmacology of Central Synapses|성=V. V. Zakusov|날짜=22 October 2013|출판사=Elsevier|쪽=190–|isbn=978-1-4831-4673-7}}</ref>
플루아시진은 다른 페노티아진과 달리 [[항정신병제제|항정신병약물]]이 아니어서, 실제로 항정신병 약물, [[리서핀|레세르핀]], [[테트라베나진]]과 같은 [[항도파민제]]에 의해 유발된 [[전신강직간대발작|강직증]] 및 [[추체외로 증상]]을 해소시키기도 하지만, [[암페타민]]으로 인한 [[상동증]] (stereotypy)을 강화시킬 수도 있다.<ref name="Zakusov2013" /> 노르에피네프린 재흡수 억제제, [[항히스타민제]], [[항콜린제]] 역할을 하는 것으로 알려져 있다.<ref name="pmid4153328">{{저널 인용|제목=Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens|저널=Bull. Exp. Biol. Med.|연도=1974|권=77|호=3|쪽=295–7|doi=10.1007/BF00802484|pmid=4153328}}</ref><ref name="pmid4441683">{{저널 인용|제목=Effect of fluacizine on the uptake of exogenous noradrenalin|저널=Bull. Exp. Biol. Med.|연도=1974|권=77|호=5|쪽=520–3|doi=10.1007/BF00797411|pmid=4441683}}</ref><ref name="pmid6305">{{저널 인용|제목=[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]|저널=Farmakol Toksikol|연도=1975|권=38|호=3|쪽=285–9|언어=ru|pmid=6305}}</ref><ref name="AcademicPress1972">{{서적 인용|url=https://books.google.com/books?id=52joNWUvZakC&pg=PA19|제목=Annual Reports in Medicinal Chemistry|날짜=27 October 1972|출판사=Academic Press|쪽=19–|isbn=978-0-08-058351-8}}</ref><ref name="Zakusov2013" /> 이 약은 1960년대에 개발되어 1970년대에 시판되었다.<ref name="Elks2014" /><ref name="pmid4153328" />
플루아시진은 클로라시진의 트리플루오로메틸 유사체이다.<ref name="AcademicPress1972" />

== 같이 보기 ==
* [[피포페진]]

== 각주 ==
{{각주}}

{{항우울제}}
{{삼환계}}

[[분류:트라이플루오로메틸 화합물]]
[[분류:페노싸이아진]]
[[분류:노르에피네프린 재흡수 억제제]]
[[분류:무스카린 대항제]]
[[분류:H1 수용체 대항제]]
[[분류:카복사마이드]]
[[분류:항우울제]]
[[분류:다이에틸아미노 화합물]]
[[분류:개발이 중지된 약]]