{{위키데이터 속성 추적}}
{{유전자 정보}}
'''[[아연집게]] 단백질 SNAI1 (Zinc finger protein SNAI1)'''은 [[단백질]]로 SNAI1[[유전자]]에 의해 암호화되어있다.<ref name="pmid10585766">{{저널 인용| author = Paznekas WA| author2 = Okajima K| author3 = Schertzer M| author4 = Wood S| author5 = Jabs EW | title = Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P) | journal = Genomics | volume = 62 | issue = 1 | pages = 42–9 | date = 2000-02 | pmid = 10585766 | pmc =  | doi = 10.1006/geno.1999.6010 }}</ref><ref name="entrez">{{웹 인용| title = Entrez Gene: SNAI1 snail homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6615| accessdate = }}</ref>

== 기능 ==
초파리 배아 단백질 SNAI1은 [[아연집게]] 전사 억제자로 [[중배엽]]내의 [[외배엽]]유전자의 발현을 하향 조절한다. 이 유전자에 의해 암호화 된 핵단백질은 구조적으로 초파리의 SNAI1 단백질과 유사하다. 그리고 발생하는 배아에 있어 중배엽의 형성에 매우 중요하다 생각된다. 2번 염색체의 최소한 두 가지의 변형된 위유전자가 발견되었다.<ref name="entrez"/>

== 임상적 중요성 ==
SNAI1 유전자는 E-[[캐드헤린]]의 CDH1[[유전자]]의 발현을 하향 조절하여 EMT(epithelial-mesenchymal transition)을 유발하여 [[유방암]]의 재발하게 함을 보여주었다.<ref name="pmid16169460">{{저널 인용| author = Davidson NE| author2 = Sukumar S | title = Of Snail, mice, and women | journal = Cancer Cell | volume = 8 | issue = 3 | pages = 173–4 | date = 2005-09 | pmid = 16169460 | doi = 10.1016/j.ccr.2005.08.006 }}</ref>

== 상호작용 ==
SNAI1은 CTDSPL<ref name="pmid19004823">{{저널 인용| author = Wu Y| author2 = Evers BM| author3 = Zhou BP | title = Small C-terminal domain phosphatase enhances snail activity through dephosphorylation | journal = J. Biol. Chem. | volume = 284 | issue = 1 | pages = 640–8 | date = 2009-01 | pmid = 19004823 | pmc = 2610500 | doi = 10.1074/jbc.M806916200 }}</ref>과 CTDSP1<ref name=pmid19004823/>과 CTDSP2과 함께 단백질 상호작용을 보여준다.<ref name=pmid19004823/>

== 각주 ==
{{각주}}

== 참고 자료 ==
{{참고 자료 시작| 2}}
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{{참고 자료 끝}}

[[분류:생물학]]
[[분류:인간 20번 염색체상 유전자]]