{{위키데이터 속성 추적}}
{{Infobox medical condition (new)
| name            = 림프종모양 육아종증
}}
'''림프종모양 육아종증'''(Lymphomatoid granulomatosis, LYG 또는 LG)은 1972년에 처음으로 특징지어진 매우 희귀한 림프증식성 장애이다.<ref>{{저널 인용|doi=10.1016/S0046-8177(72)80005-4 |pmid=4638966 |title=Lymphomatoid granulomatosis |journal=Human Pathology |volume=3 |issue=4 |pages=457–558 |year=1972 |last1=Liebow |first1=Averill A. |last2=Carrington |first2=Charles R.B. |last3=Friedman |first3=Paul J. |pmc=1518397 }}</ref> 림프종모양 육아종증은 [[림프종]]과 유사한 것을 의미하며 [[육아종|육아종증]]은 다형성 림프성 침윤 및 그 안에 국소 괴사가 있는 육아종 존재의 미세한 특징을 나타낸다.

LG는 중년층에 가장 흔히 영향을 미치지만<ref>{{저널 인용|doi=10.1097/PAS.0000000000000328 |pmid=25321327 |pmc=4293220 |title=Lymphomatoid Granulomatosis—A Single Institute Experience |journal=The American Journal of Surgical Pathology |volume=39 |issue=2 |pages=141–56 |year=2015 |last1=Song |first1=Joo Y. |last2=Pittaluga |first2=Stefania |last3=Dunleavy |first3=Kieron |last4=Grant |first4=Nicole |last5=White |first5=Therese |last6=Jiang |first6=Liuyan |last7=Davies-Hill |first7=Theresa |last8=Raffeld |first8=Mark |last9=Wilson |first9=Wyndham H. |last10=Jaffe |first10=Elaine S. }}</ref> 젊은층에서도 가끔 관찰된다.<ref>{{저널 인용|doi=10.1097/MPH.0000000000000090 |pmid=24390446 |title=Childhood Lymphomatoid Granulomatosis: A Report of 2 Cases and Review of the Literature |journal=Journal of Pediatric Hematology/Oncology |volume=36 |issue=7 |pages=e416–22 |year=2014 |last1=Tacke |first1=Zwanique C. A. |last2=Eikelenboom |first2=M. Judith |last3=Vermeulen |first3=R. Jeroen |last4=Van Der Knaap |first4=Marjo S. |author-link4=Marjo van der Knaap |last5=Euser |first5=Anne M. |last6=Van Der Valk |first6=Paul |last7=Kaspers |first7=Gertjan J. L. |s2cid=11047705 }}</ref> 남성은 여성보다 2배 더 자주 영향을 받는 것으로 나타났다.<ref name=pmid21107080>{{저널 인용|doi=10.1097/PAS.0b013e3181fd8781 |pmid=21107080 |title=Lymphomatoid Granulomatosis |journal=The American Journal of Surgical Pathology |volume=34 |issue=12 |pages=e35–48 |year=2010 |last1=Katzenstein |first1=Anna-Luise A. |last2=Doxtader |first2=Erika |last3=Narendra |first3=Sonia |s2cid=41027533 }}</ref>

== 원인 ==
림프종모양 육아종증은 악성 B 세포와 반응성, 비악성 T 세포를 포함하며 거의 항상 [[엡스타인-바 바이러스]]에 의한 악성 B 세포의 감염과 연관되어 있다.<ref name="pmid29885408">{{저널 인용| vauthors = Rezk SA, Zhao X, Weiss LM | title = Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update | journal = Human Pathology | volume = 79 | pages = 18–41 | date = September 2018 | pmid = 29885408 | doi = 10.1016/j.humpath.2018.05.020 | s2cid = 47010934 }}</ref> 따라서 이는 엡스타인-바 바이러스 관련 림프증식성 질환의 한 형태로 간주된다. 이 질병은 엡스타인 바 바이러스 감염과 면역억제제(메토트렉세이트<ref name=pmid23733760>{{저널 인용|doi=10.1200/JCO.2012.46.2770 |pmid=23733760 |title=Methotrexate-Induced Lymphoproliferative Disease: Epstein-Barr Virus-Associated Lymphomatoid Granulomatosis |journal=Journal of Clinical Oncology |volume=31 |issue=20 |pages=e348–50 |year=2013 |last1=Ochi |first1=N. |last2=Yamane |first2=H. |last3=Yamagishi |first3=T. |last4=Monobe |first4=Y. |last5=Takigawa |first5=N. }}</ref><ref name=pmid23857444>{{저널 인용|pmid=23857444 |url=http://www.minervamedica.it/index2.t?show=R02Y2014N01A0119 |year=2014 |last1=Blanchart |first1=K |title=Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis |journal=Minerva Anestesiologica |volume=80 |issue=1 |pages=119–20 |last2=Paciencia |first2=M |last3=Seguin |first3=A |last4=Chantepie |first4=S |last5=Du Cheyron |first5=D |last6=Charbonneau |first6=P |last7=Galateau-Salle |first7=F |last8=Terzi |first8=N }}</ref><ref>{{저널 인용|doi=10.2169/internalmedicine.53.2593 |pmid=25130128 |title=Grade 3 Lymphomatoid Granulomatosis in a Patient Receiving Methotrexate Therapy for Rheumatoid Arthritis |journal=Internal Medicine |volume=53 |issue=16 |pages=1873–5 |year=2014 |last1=Oiwa |first1=Hiroshi |last2=Mihara |first2=Keichiro |last3=Kan |first3=Takanobu |last4=Tanaka |first4=Maiko |last5=Shindo |first5=Hajime |last6=Kumagai |first6=Kazuhiko |last7=Sugiyama |first7=Eiji |doi-access=free }}</ref><ref>{{저널 인용|pmid=24681935 |doi=10.11406/rinketsu.55.321 |year=2014 |last1=Yamakawa |first1=T |title=メトトレキサート中止と脳病変への放射線照射が奏効したメトトレキサート関連リンパ腫様肉芽腫症 |trans-title=Methotrexate-related lymphomatoid granulomatosis successfully treated with discontinuation of methotrexate and radiotherapy to brain |language=ja |journal=Rinsho Ketsueki |volume=55 |issue=3 |pages=321–6 |last2=Kurosawa |first2=M |last3=Yonezumi |first3=M |last4=Suzuki |first4=S |last5=Suzuki |first5=H }}</ref><ref>{{저널 인용|doi=10.1007/s00277-013-1741-1 |pmid=23529185 |title=Reversible iatrogenic, MTX-associated EBV-driven lymphoproliferation with histopathological features of a lymphomatoid granulomatosis in a patient with rheumatoid arthritis |journal=Annals of Hematology |volume=92 |issue=11 |pages=1561–4 |year=2013 |last1=Kobayashi |first1=Shinichi |last2=Kikuchi |first2=Yuichi |last3=Sato |first3=Kimiya |last4=Matsukuma |first4=Susumu |last5=Matsuki |first5=Yasunori |last6=Horikoshi |first6=Hideyuki |last7=Nagumo |first7=Morichika |last8=Kobayashi |first8=Ayako |last9=Masuoka |first9=Kazuhiro |last10=Kimura |first10=Fumihiko |last11=Oshima |first11=Satoshi |last12=Hakozaki |first12=Yukiya |last13=Kondo |first13=Toshiro |s2cid=26750255 }}</ref><ref>{{저널 인용|pmid=21894776 |year=2011 |last1=Inaba |first1=M |title=Methotrexate-related lymphomatoid granulomatosis in a patient with rheumatoid arthritis |journal=Nihon Kokyuki Gakkai Zasshi |volume=49 |issue=8 |pages=597–601 |last2=Ushijim |first2=S |last3=Hirata |first3=N |last4=Saisyoji |first4=T |last5=Kitaoka |first5=M |last6=Yoshinaga |first6=T }}</ref><ref>{{저널 인용|doi=10.1159/000218356 |pmid=19556825 |title=Lymphomatoid Granulomatosis in a Patient with Rheumatoid Arthritis Receiving Methotrexate: Successful Treatment with the Anti-CD20 Antibody Mabthera |journal=Onkologie |volume=32 |issue=7 |pages=440–1 |year=2009 |last1=Schalk |first1=Enrico |last2=Krogel |first2=Christian |last3=Scheinpflug |first3=Katrin |last4=Mohren |first4=Martin |doi-access=free }}</ref><ref>{{저널 인용|doi=10.1080/03009740600902403 |pmid=17454938 |title=Methotrexate‐related lymphomatoid granulomatosis: A case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis |journal=Scandinavian Journal of Rheumatology |volume=36 |issue=1 |pages=64–7 |year=2007 |last1=Shimada |first1=K. |last2=Matsui |first2=T. |last3=Kawakami |first3=M. |last4=Nakayama |first4=H. |last5=Ozawa |first5=Y. |last6=Mitomi |first6=H. |last7=Tohma |first7=S. |s2cid=41605244 }}</ref><ref>{{저널 인용|doi=10.1007/s10067-006-0480-2 |pmid=17200802 |title=Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis |journal=Clinical Rheumatology |volume=26 |issue=9 |pages=1585–9 |year=2007 |last1=Kameda |first1=Hideto |last2=Okuyama |first2=Ayumi |last3=Tamaru |first3=Jun-Ichi |last4=Itoyama |first4=Shinji |last5=Iizuka |first5=Atsushi |last6=Takeuchi |first6=Tsutomu |s2cid=21583991 }}</ref> 및 아자티오프린<ref>{{저널 인용|pmid=25674479 |pmc=4320142 |year=2014 |last1=Barakat |first1=Athar |title=Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis |journal=SpringerPlus |volume=3 |pages=751 |last2=Grover |first2=Karan |last3=Peshin |first3=Rohit |doi=10.1186/2193-1801-3-751 }}</ref><ref>{{저널 인용|doi=10.1186/1471-230X-14-127 |pmid=25022612 |pmc=4105046 |title=Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease |journal=BMC Gastroenterology |volume=14 |pages=127 |year=2014 |last1=Connors |first1=William |last2=Griffiths |first2=Cameron |last3=Patel |first3=Jay |last4=Belletrutti |first4=Paul J }}</ref>에 대한 사례 보고 포함)를 통한 면역억제, HIV 또는 만성 바이러스 간염과 같은 감염 또는 내인성 [[T세포]] 결함이 결합되어 유발되는 것으로 여겨진다.<ref name="pmid23006954">{{저널 인용|doi=10.1097/PPO.0b013e31826c5e19 |pmid=23006954 |title=Lymphomatoid Granulomatosis |journal=The Cancer Journal |volume=18 |issue=5 |pages=469–74 |year=2012 |last1=Roschewski |first1=Mark |last2=Wilson |first2=Wyndham H. |s2cid=8958101 |url=https://zenodo.org/record/1234903 |type=Submitted manuscript }}</ref>

== 각주 ==
{{각주}}

{{Medical resources
|  DiseasesDB     = 33208
|   ICD10          = 
|   ICD9           = 
|   ICDO           = 9766/1
|   OMIM           = 
|   MedlinePlus    = 
|   eMedicineSubj  = med
|   eMedicineTopic = 1369
|   MeshID         = D008230
}}

[[분류:엡스타인-바 바이러스 관련 질병]]