{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 1147600369
| IUPAC_name = ''N''-(2,6-Dimethylphenyl)-5,6-dihydro-4''H''-1,3-thiazin-2-amine
| image = Xylazine.svg
| width = 160
| image2 = Xylazine ball-and-stick model.png

<!--Clinical data-->
| tradename =  Rompun, Anased, Sedazine, Chanazine
| Drugs.com = {{drugs.com|international|xylazine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =  
| legal_AU = S4
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = Rx-only
| legal_status = Veterinary Use
| routes_of_administration = [[Oral administration|By mouth]], inhalation, or injection (intravenous, intramuscular, or subcutaneous)

<!--Pharmacokinetic data-->
| bioavailability =  
| protein_bound =  
| metabolism =  
| elimination_half-life =  
| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 7361-61-7
| ATCvet = yes
| ATC_prefix = N05
| ATC_suffix = CM92
| PubChem = 5707
| IUPHAR_ligand = 523
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5505
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 2KFG9TP5V8
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08683
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 297362

<!--Chemical data-->
| C=12 | H=16 | N=2 | S=1
| smiles = N\1=C(\SCCC/1)Nc2c(cccc2C)C
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = BPICBUSOMSTKRF-UHFFFAOYSA-N}}
'''자일라진'''(xylazine)은 말과 소, 기타 비인간 포유류와 같은 동물의 [[진정작용|진정]], [[마취]], [[근수축|근이완]], [[진통제|진통]]에 사용되는 의약품이다.<ref name="Xylazine">{{웹 인용|url=https://techynewsblogs.com/this-drug-is-turning-people-into-zombies-xylazine|title=Xylazine|website=techynewsblogs.com}}</ref> 수의사들이 특히 고양이에게 [[구토|구토유도제]]로 사용하기도 한다.<ref name="PDowling">{{서적 인용|title=Merck Veterinary Manual|date=June 2016|edition=professional|publisher=Merck & Co.|place=Rahway, NJ|vauthors=Dowling PM|orig-date=March 2015|section=Drugs to control or stimulate vomiting (monogastric)|section-url=https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-to-control-or-stimulate-vomiting-monogastric}}</ref> [[클로니딘]]의 유사체이자 α2 계열의 [[아드레날린 수용체]]에 작용하는 [[효능제]]이다.<ref name="Greene">{{저널 인용|title=Xylazine—a review of its pharmacology and use in veterinary medicine|journal=Journal of Veterinary Pharmacology and Therapeutics|date=December 1988|volume=11|issue=4|pages=295–313|doi=10.1111/j.1365-2885.1988.tb00189.x|pmid=3062194|vauthors=Greene SA, Thurmon JC}}</ref>

[[수의과 마취]]에서 자일라진은 종종 [[케타민]]과 함께 사용된다. 전세계적으로 수많은 브랜드명으로 판매되고 있으며, 이 중에서는 특히 [[바이엘 (기업)|바이엘]]의 브랜드명 럼푼이 가장 유명하다.<ref name="Xylazine" /> 아나세드, 세다진, 차나진이라는 이름으로도 판매되고 있다.<ref name="Ruiz!">{{저널 인용|title=Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature|journal=Forensic Science International|date=July 2014|volume=240|pages=1–8|doi=10.1016/j.forsciint.2014.03.015|pmid=24769343|vauthors=Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA}}</ref> 약물의 상호 작용은 동물마다 다르다.<ref name="Haskins">{{저널 인용|title=Xylazine and xylazine-ketamine in dogs|journal=American Journal of Veterinary Research|date=March 1986|volume=47|issue=3|pages=636–641|pmid=3963565|vauthors=Haskins SC, Patz JD, Farver TB}}</ref><ref name="Muir">{{저널 인용|title=Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses|journal=American Journal of Veterinary Research|date=February 1977|volume=38|issue=2|pages=195–201|pmid=842917|vauthors=Muir WW, Skarda RT, Milne DW}}</ref><ref name="Aithal">{{저널 인용|title=Clinical effects of epidurally administered ketamine and xylazine in goats|journal=Small Ruminant Research|year=1997|volume=24|issue=1|pages=55–64|doi=10.1016/s0921-4488(96)00919-4|vauthors=Aithal HP, Pratap AK, Singh GR}}</ref>

자일라진은 미국에서 "'''트랭크'''"(tranq)라는 이름으로 통하는 남용 약물이 되었으며, [[푸에르토리코]]에서도 문제가 되고 있다.<ref name="Torruella">{{저널 인용|title=Xylazine (veterinary sedative) use in Puerto Rico|journal=Substance Abuse Treatment, Prevention, and Policy|date=April 2011|volume=6|pages=7|doi=10.1186/1747-597x-6-7|pmc=3080818|pmid=21481268|vauthors=Torruella RA}}</ref> 말 [[수의사]]가 사용하는 재고를 마약으로 전용하여 [[헤로인]]의 커팅제로 사용하며, 주사 부위에 피부 염증과 감염을 유발하는 등 여러 건강 문제를 일으키고 있다.<ref name="Reyes">{{저널 인용|title=The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico|journal=Journal of Urban Health|date=June 2012|volume=89|issue=3|pages=519–526|doi=10.1007/s11524-011-9662-6|pmc=3368046|pmid=22391983|vauthors=Reyes JC, Negrón JL, Colón HM, Padilla AM, Millán MY, Matos TD, Robles RR}}</ref>

== 각주 ==
{{각주}}

[[분류:알파 작용제]]
[[분류:진통제]]
[[분류:싸이아진]]