{{위키데이터 속성 추적}}
{{Drugbox
| verifiedrevid = 447377111
| IUPAC_name = Octacosanol, triacontanol, etc.
| image = Fatty alcohol - generic.png

<!--Clinical data-->
| tradename =  
| Drugs.com = {{drugs.com|international|policosanol}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category =  
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =  
| routes_of_administration =

<!--Pharmacokinetic data-->
| bioavailability =  
| protein_bound =  
| metabolism =  
| elimination_half-life =  
| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 142583-61-1
| ATC_prefix = C10
| ATC_suffix = AX08
| PubChem =  
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID = NA

<!--Chemical data-->
| chemical_formula = CH<sub>3</sub>-(CH<sub>2</sub>)<sub>n</sub>-CH<sub>2</sub>OH n=24-34

| molecular_weight = (variable)
}}

'''폴리코사놀'''({{llang|en|policosanol}})은 [[사탕수수]] 등 식물 [[왁스]]나 [[밀랍]] 등에서 추출한 천연 [[지방 알코올]] 추출물을 총칭하는 이름이다. 주로 [[식이 보충제|건강 보조 식품]]에 사용되며, 보통 [[저밀도 지질단백질]](LDL)을 낮추고 [[고밀도 지질단백질]](HDL)을 높여주는 효과가 있는 것으로 알려져 [[동맥경화]]를 방지하기 위한 [[영양 보충제]]로 사용되나 폴리코사놀의 효능에 대해서는 논쟁이 있다.

여러 연구가 진행되었으나 폴리코사놀이 [[저밀도 지질단백질]](LDL)을 낮추고 [[고밀도 지질단백질]](HDL)을 높여준다는 효과에는 서로 상반되는 연구가 나오는 등 논쟁이 있다.<ref name="negative">{{저널 인용 |author1 = Heiner K. Berthold |author2 = Susanne Unverdorben |author3 = Ralf Degenhardt |author4 = Michael Bulitta |author5 = Ioanna Gouni-Berthold |date = May 17, 2006 |title = Effect of Policosanol on Lipid Levels Among Patients With Hypercholesterolemia or Combined Hyperlipidemia |journal = Journal of the American Medical Association |volume = 295 |issue = 19 |pages = 2262–2269 |url = http://jama.ama-assn.org/cgi/content/abstract/295/19/2262 |accessdate = 2006-10-03 |pmid = 16705107 |doi = 10.1001/jama.295.19.2262}}</ref><ref name="positive">{{저널 인용 |author1 = Pons P |author2 = Rodriguez M |author3 = Robaina C |author4 = Illnait J |author5 = Mas R |author6 = Fernandez L |author7 = Fernandez JC. |year = 1994 |title = Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment |journal = International Journal of Clinical Pharmacology Research |volume = 14 |issue = 1 |pages = 27–33 |pmid = 7927958 |accessdate = }}</ref><ref name="pmid15767233">{{저널 인용 |author1=Chen JT |author2=Wesley R |author3=Shamburek RD |author4=Pucino F |author5=Csako G |title=Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol |journal=Pharmacotherapy |volume=25 |issue=2 |pages=171–83 |year=2005 |pmid=15767233 |doi=10.1592/phco.25.2.171.56942 |url= }}</ref> 쿠바 정부는 폴리코사놀의 연구에 대해 많은 지원을 하면서 약을 생산하고 판매하고 있다.<ref>{{저널 인용 | journal = Nature Biotechnology | volume = 22 | issue = 12s | pages = DC19–DC24 | year = 2004 | doi = 10.1038/nbt1204supp-DC19 | title = Cuba—innovation through synergy | url = http://www.nature.com/nbt/journal/v22/n12s/fig_tab/nbt1204supp-DC19_T1.html | author = Thorsteinsdóttir, Halla | pmid = 15583679 | last2 = Sáenz | first2 = TW | last3 = Quach | first3 = U | last4 = Daar | first4 = AS | last5 = Singer | first5 = PA}}</ref> 여러 독립된 임상 실험 결과에서는 폴리코사놀의 효과가 없으나,<ref name="negative" /> 기타 다른 연구에서는 이상지질혈증 등에<ref>{{저널 인용|제목=Efficacy and safety of sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled trials|저널=Molecular Nutrition & Food Research|성=Gong|이름=Jing|성2=Qin|이름2=Xin|url=http://doi.wiley.com/10.1002/mnfr.201700280|날짜=2018-1|권=62|호=1|쪽=1700280|언어=en|doi=10.1002/mnfr.201700280|성3=Yuan|이름3=Fen|성4=Hu|이름4=Meilin|성5=Chen|이름5=Guang|성6=Fang|이름6=Ke|성7=Wang|이름7=Dingkun|성8=Jiang|이름8=Shujun|성9=Li|이름9=Jingbin}}</ref> 효과가 있다고도 주장한다.<ref>{{저널 인용
| last1 = Liu | first1 = S.
| last2 = Tan | first2 = M. Y.
| last3 = Zhao | first3 = S. P.
| last4 = Rong | first4 = H.
| title = Effects of policosanol on serum lipids and heme oxygenase-1 in patients with hyperlipidemia
| journal = Zhonghua xin xue guan bing za zhi
| volume = 40
| issue = 10
| pages = 840–843
| year = 2012
| pmid = 23302671
}}</ref><ref>{{저널 인용
| last1 = Zanardi | first1 = M.
| last2 = Quirico | first2 = E.
| last3 = Benvenuti | first3 = C.
| last4 = Pezzana | first4 = A.
| title = Use of a lipid-lowering food supplement in patients on hormone therapy following breast cancer
| journal = Minerva ginecologica
| volume = 64
| issue = 5
| pages = 431–435
| year = 2012
| pmid = 23018482
}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* {{언어링크|en}} [http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pol_0207.shtml Policosanol] at PDRHealth.com
* {{US patent|6225354}}

{{토막글|의학}}

[[분류:천연물]]
[[분류:식이 보충제]]
[[분류:지방 알코올]]
[[분류:알칸올]]