{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 456484490
| IUPAC_name = 1-cyano-2-methyl-3-[2-[(5-methyl-1''H''-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
| image = 
| width = 250px
| image2 = Cimetidine-xtal-3D-balls.png
| width2 = 250px

<!--Clinical data-->
| pronounce = {{IPAc-en|s|ᵻ|ˈ|m|ɛ|t|ᵻ|d|iː|n}} or {{IPAc-en|s|aɪ|ˈ|m|ɛ|t|ᵻ|d|iː|n}}
| tradename = Tagamet, others
| Drugs.com = {{drugs.com|monograph|cimetidine}}
| MedlinePlus = a682256
| licence_US = Cimetidine
| pregnancy_AU = B1
| pregnancy_US = B
| legal_AU = S4
| legal_UK = POM
| legal_US = Rx-only
| legal_US_comment = (although 200 mg is OTC)
| routes_of_administration = [[Oral administration|By mouth]], [[intramuscular injection]], [[intravenous therapy|intravenous infusion]]<ref name="GuptaSingh-Radcliff2013">{{서적 인용|author1=Anita Gupta|author2=Nina Singh-Radcliff|title=Pharmacology in Anesthesia Practice|url=https://books.google.com/books?id=a85oAgAAQBAJ&pg=PT177|date=12 March 2013|publisher=Oxford University Press|isbn=978-0-19-934399-7|pages=177–}}</ref>

<!--Pharmacokinetic data-->
| bioavailability = 60–70%<ref name="DowdJohnson2016">{{서적 인용|author1=Frank J. Dowd|author2=Bart Johnson|author3=Angelo Mariotti|title=Pharmacology and Therapeutics for Dentistry - E-Book|url=https://books.google.com/books?id=6xT7DAAAQBAJ&pg=PA406|date=3 September 2016|publisher=Elsevier Health Sciences|isbn=978-0-323-44595-5|pages=406–}}</ref><ref name="LeikinPaloucek1995">{{서적 인용|author1=Jerrold B. Leikin|author2=Frank P. Paloucek|title=Poisoning & Toxicology Handbook, 1995-1996|url=https://books.google.com/books?id=JpZrAAAAMAAJ|year=1995|publisher=Lexi-Comp, Incorporated|isbn=978-0-916589-08-0|page=184}}</ref>
| protein_bound = 13–25%<ref name="LeikinPaloucek1995" /><ref name="AcademicPress1984">{{서적 인용|title=Profiles of Drug Substances, Excipients and Related Methodology|url=https://books.google.com/books?id=Fz6X-GmS-GgC&pg=PA176|date=24 October 1984|publisher=Academic Press|isbn=978-0-08-086108-1|pages=176–}}</ref>
| metabolism = [[Liver]]<ref name="LeikinPaloucek1995" />
| metabolites = • Cimetidine sulfoxide<ref name="LeikinPaloucek1995" /><br />• Hydroxycimetidine<ref name="LeikinPaloucek1995" /><br />• Guanyl urea cimetidine<ref name="LeikinPaloucek1995" />
| onset = 30 minutes<ref name="VallerandSanoski2016" />
| elimination_half-life = 123 minutes (~2 hours)<ref name="AcademicPress1984" />
| duration_of_action = 4–8 hours<ref name="GuptaSingh-Radcliff2013">{{서적 인용|author1=Anita Gupta|author2=Nina Singh-Radcliff|title=Pharmacology in Anesthesia Practice|url=https://books.google.com/books?id=a85oAgAAQBAJ&pg=PT177|date=12 March 2013|publisher=Oxford University Press|isbn=978-0-19-934399-7|pages=177–}}</ref>
| excretion = [[Urine]]<ref name="AcademicPress1984" />

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 51481-61-9
| ATC_prefix = A02
| ATC_suffix = BA01
| PubChem = 2756
| IUPHAR_ligand = 1231
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00501
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2654
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 80061L1WGD
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00295
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 3699
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 30
| synonyms = SKF-92334<ref name="Elks2014">{{서적 인용| first = J. | last = Elks | name-list-format = vanc | title = The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | url = https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA275 | date = 14 November 2014 | publisher = Springer | isbn = 978-1-4757-2085-3 | pages = 275– }}</ref>

<!--Chemical data-->
| C=10 | H=16 | N=6 | S=1
| molecular_weight = 252.34 g/mol
| SMILES = CC1=C(N=CN1)CSCCNC(=NC)NC#N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = AQIXAKUUQRKLND-UHFFFAOYSA-N
}}
'''시메티딘'''(Cimetidine)은 [[위장]] 내에서 위산의 분비를 억제하는 약물로서, [[위염]] 또는 [[위궤양]] 등의 증상에 아주 빈번하게 처방되고 있다. 약물학적 전문용어로 H2 수용체 차단제 (H2-receptor antagonist) 계열에 속한다. 상표명 '''타가메트'''(Tagamet)로도 알려져 있다.

== 각주 ==
{{각주}}

{{전거 통제}}
{{토막글|의학}}

[[분류:H2 수용체 길항제]]
[[분류:이미다졸]]
[[분류:나이트릴]]
[[분류:싸이오에터]]
[[분류:간독소]]
[[분류:항안드로겐]]
[[분류:글락소스미스클라인의 제품]]
[[분류:콩팥 독소]]
[[분류:사이토크롬 P450 억제제]]
[[분류:비스테로이드성 항안드로겐]]
[[분류:CYP1A2 억제제]]