{{위키데이터 속성 추적}}
'''퇴행성 질환'''(退行性疾患, {{llang|en|degenerative disease}})은 퇴행성 세포 변화에 기반한 지속적인 과정의 결과로, [[조직 (생물학)|조직]]이나 [[기관 (해부학)|기관]]에 영향을 미치며 시간이 지남에 따라 점점 더 악화된다.<ref name=":3">{{웹 인용|url=https://www.docdoc.com.sg/info/condition/degenerative-disease/|title=What is Degenerative Disease|website=docdoc.com.sg|archive-url=https://web.archive.org/web/20180917213617/https://www.docdoc.com.sg/info/condition/degenerative-disease/|archive-date=2018-09-17|url-status=live|access-date=2018-09-17}}</ref>

[[신경퇴행성 질환]]에서는 중추신경계 세포가 신경퇴행을 통해 작동을 멈추거나 죽는다. 신경퇴행성 질환의 대표적인 예는 [[알츠하이머병]]이다.<ref>{{웹 인용|url=https://www.cancer.gov/publications/dictionaries/cancer-terms/def/neurodegenerative-disorder|title=neurodegenerative disorder|date=2011-02-02|website=National Cancer Institute|archive-url=https://web.archive.org/web/20180423115832/https://www.cancer.gov/publications/dictionaries/cancer-terms/def/neurodegenerative-disorder|archive-date=2018-04-23|url-status=live|access-date=2018-09-17}}</ref> 퇴행성 질환의 다른 두 가지 일반적인 부류는 [[순환계]]에 영향을 미치는 질환(예: [[관상동맥 질환]])과 [[신생물|종양성]] 질환(예: [[암]])이다.<ref name=":3" />

많은 퇴행성 질환이 존재하며 일부는 [[노화]]와 관련이 있다. 정상적인 신체 사용이나 생활 습관(예: [[운동 (활동)|운동]], 식습관)이 퇴행성 질환을 악화시킬 수 있지만 이는 질병에 따라 다르다.<ref name=":3" /> 때때로 이러한 질병의 주된 또는 부분적인 원인은 [[유전자|유전적]] 요인이다.<ref name=":4">{{뉴스 인용|url=https://medlineplus.gov/degenerativenervediseases.html|title=Neurodegenerative Diseases|access-date=2018-09-17|archive-url=https://web.archive.org/web/20180728020542/https://medlineplus.gov/degenerativenervediseases.html|archive-date=2018-07-28|url-status=live}}</ref> 따라서 일부는 [[헌팅턴병]]과 같이 분명히 유전적이다.<ref name=":5">{{저널 인용|last=Nopoulos|first=PC|date=2016|title=Huntington disease: a single-gene degenerative disorder of the striatum|journal=Dialogues in Clinical Neuroscience|volume=18|issue=1|pages=91–98|doi=10.31887/DCNS.2016.18.1/pnopoulos|issn=1294-8322|pmc=4826775|pmid=27069383}}</ref> 때로는 원인이 [[바이러스]], [[독극물]] 또는 기타 [[화학 물질]]인 경우도 있다. 원인을 알 수 없는 경우도 있다.<ref name=":4" />

일부 퇴행성 질환은 치료될 수 있다. 그렇지 않은 경우에는 증상을 [[완화치료|완화]]시키는 것이 가능할 수도 있다.<ref name=":3" />

== 예 ==
{{div col|colwidth=22em}}
* [[알츠하이머병]] (AD)<ref name=":0">{{저널 인용|last1=Soto|first1=C|last2=Satani|first2=N|date=2011|title=The intricate mechanisms of neurodegeneration in prion diseases|journal=Trends in Molecular Medicine|volume=17|issue=1|pages=14–24|doi=10.1016/j.molmed.2010.09.001|issn=1471-4914|pmc=3056171|pmid=20889378}}</ref>
* [[근위축성 측삭경화증]]<ref name=":0" /> (ALS, [[루게릭병]])
* [[암]]<ref name=":3"/>
* [[샤르코 마리 투스 질환]] (CMT)<ref>{{저널 인용|last1=Patzkó|first1=Á|last2=Shy|first2=ME|date=2011|title=Update on Charcot-Marie-Tooth Disease|journal=Current Neurology and Neuroscience Reports|volume=11|issue=1|pages=78–88|doi=10.1007/s11910-010-0158-7|issn=1528-4042|pmc=3685483|pmid=21080241}}</ref>
* [[만성 외상성 뇌병증]]<ref>{{저널 인용|last1=Maroon|first1=JC|last2=Winkelman|first2=R|last3=Bost|first3=J|last4=Amos|first4=A|last5=Mathyssek|first5=C|last6=Miele|first6=V|date=2015-02-11|title=Chronic Traumatic Encephalopathy in Contact Sports: A Systematic Review of All Reported Pathological Cases|journal=PLOS ONE|volume=10|issue=2|pages=e0117338|doi=10.1371/journal.pone.0117338|issn=1932-6203|pmc=4324991|pmid=25671598|bibcode=2015PLoSO..1017338M|doi-access=free}}</ref>
* [[낭포성 섬유증]]<ref>{{저널 인용|last1=Fraser-Pitt|first1=D|last2=O’Neil|first2=D|date=2015|title=Cystic fibrosis – a multiorgan protein misfolding disease|journal=Future Science OA|volume=1|issue=2|pages=FSO57|doi=10.4155/fso.15.57|pmid=28031875|pmc=5137970|issn=2056-5623}}</ref>
* 일부 [[사이토크롬 c 산화효소]] 결핍증 (종종 퇴행성 [[리 증후군]]의 원인)<ref>{{웹 인용|url=https://rarediseases.info.nih.gov/diseases/48/cytochrome-c-oxidase-deficiency|title=Cytochrome c oxidase deficiency|website=rarediseases.info.nih.gov|archive-url=https://web.archive.org/web/20171022084730/https://rarediseases.info.nih.gov/diseases/48/cytochrome-c-oxidase-deficiency|archive-date=2017-10-22|url-status=live|access-date=2018-09-17}}</ref>
* [[엘리스-단로스 증후군]]<ref>{{웹 인용|url=https://rarediseases.info.nih.gov/diseases/6322/ehlers-danlos-syndromes|title=Ehlers-Danlos syndromes|website=rarediseases.info.nih.gov|archive-url=https://web.archive.org/web/20180616001941/https://rarediseases.info.nih.gov/diseases/6322/ehlers-danlos-syndromes|archive-date=2018-06-16|url-status=live|access-date=2018-09-17}}</ref>
* [[진행성 골화성 섬유이형성증]]
* [[프리드라이히 운동실조증]]<ref>{{저널 인용|last1=Delatycki|first1=M|last2=Williamson|first2=R|last3=Forrest|first3=S|date=2000|title=Friedreich ataxia: an overview|journal=Journal of Medical Genetics|volume=37|issue=1|pages=1–8|doi=10.1136/jmg.37.1.1|issn=0022-2593|pmc=1734457|pmid=10633128}}</ref>
* [[전두측두엽치매]] (FTD)<ref>{{저널 인용|last1=Warren|first1=JD|last2=Rohrer|first2=JD|last3=Rossor|first3=MN|date=2013-08-06|title=Frontotemporal dementia|journal=The BMJ|volume=347|pages=f4827|doi=10.1136/bmj.f4827|issn=0959-8138|pmc=3735339|pmid=23920254}}</ref>
* 일부 [[심혈관계 질환]] (예: [[관상동맥 질환]], [[대동맥 협착증]], [[선천적 결함]] 등과 같은 [[죽상경화증|죽상경화성]] 질환)<ref>{{저널 인용|last=Barik|first=R|date=2016|title=Degenerative aortic valve disease and coronary artery disease are either side of a coin|journal=Indian Heart Journal|volume=68|issue=3|pages=432|doi=10.1016/j.ihj.2015.09.010|issn=0019-4832|pmc=4911461|pmid=27316510}}</ref>
* [[헌팅턴병]]<ref name=":5" />
* [[영아 신경축삭 이영양증]]<ref>{{저널 인용|last1=Li|first1=H|last2=Zou|first2=Y|last3=Bao|first3=X|last4=Wang|first4=H|last5=Wang|first5=J|last6=Jin|first6=H|last7=Che|first7=Y|last8=Tang|first8=X|date=2016|title=Monozygotic twins with infantile neuroaxonal dystrophy: A case report and literature review|journal=Experimental and Therapeutic Medicine|volume=12|issue=5|pages=3387–3389|doi=10.3892/etm.2016.3761|issn=1792-0981|pmc=5103811|pmid=27882168}}</ref>
* [[원추각막]] (KC)<ref>{{저널 인용|last1=Davidson|first1=AE|last2=Hayes|first2=S|last3=Hardcastle|first3=AJ|last4=Tuft|first4=SJ|date=2014|title=The pathogenesis of keratoconus|journal=Eye|volume=28|issue=2|pages=189–195|doi=10.1038/eye.2013.278|issn=0950-222X|pmc=3930280|pmid=24357835}}</ref>
* [[구형각막]]<ref>{{저널 인용|last1=Wallang|first1=BS|last2=Das|first2=S|date=2013|title=Keratoglobus|journal=Eye|volume=27|issue=9|pages=1004–1012|doi=10.1038/eye.2013.130|issn=0950-222X|pmc=3772364|pmid=23807384}}</ref>
* [[백질이영양증]]<ref>{{저널 인용|last1=van der Knaap|first1=MS|last2=Bugiani|first2=M|date=2017|title=Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms|journal=Acta Neuropathologica|volume=134|issue=3|pages=351–382|doi=10.1007/s00401-017-1739-1|issn=0001-6322|pmc=5563342|pmid=28638987}}</ref>
* [[황반변성]] (AMD)<ref>{{저널 인용|last1=Anand|first1=A|last2=Sharma|first2=K|last3=Chen|first3=W|last4=Sharma|first4=NK|date=2014|title=Using Current Data to Define New Approach in Age Related Macular Degeneration: Need to Accelerate Translational Research|journal=Current Genomics|volume=15|issue=4|pages=266–277|doi=10.2174/1389202915666140516204512|issn=1389-2029|pmc=4133950|pmid=25132797}}</ref>
* [[마르판 증후군]] (MFS)<ref>{{저널 인용|last1=Gao|first1=L|last2=Luo|first2=F|last3=Hui|first3=R|last4=Zhou|first4=X|date=2010|title=Recent molecular biological progress in Marfan syndrome and Marfan-associated disorders|journal=Ageing Research Reviews|language=en|volume=9|issue=3|pages=363–368|doi=10.1016/j.arr.2009.09.001|pmid=19772952|s2cid=205666350|issn=1568-1637}}</ref>
* 일부 [[미토콘드리아 근육병증]]<ref>{{뉴스 인용|url=https://rarediseases.org/rare-diseases/melas-syndrome/|title=MELAS Syndrome|work=NORD (National Organization for Rare Disorders)|access-date=2018-09-17|archive-url=https://web.archive.org/web/20170220090745/https://rarediseases.org/rare-diseases/melas-syndrome/|archive-date=2017-02-20|url-status=live}}</ref>
* [[미토콘드리아 DNA 고갈 증후군]]<ref>{{저널 인용|last1=El-Hattab|first1=AW|last2=Scaglia|first2=F|date=2013|title=Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options|journal=Neurotherapeutics|volume=10|issue=2|pages=186–198|doi=10.1007/s13311-013-0177-6|issn=1933-7213|pmc=3625391|pmid=23385875}}</ref>
* [[뮐러-바이스 증후군]]<ref>{{저널 인용|last1=Hermena |first1=Shady |last2=Francis |first2=Monica |date=2021-10-11 |title=Clinical Presentation, Imaging Features, and Management of Müller–Weiss Disease |journal=Cureus |language=en |volume=13 |issue=10 |pages=e18659 |doi=10.7759/cureus.18659 |pmid=34786245 |pmc=8579404 |issn=2168-8184|doi-access=free }}</ref>
* [[다발성 경화증]] (MS)<ref>{{저널 인용|last1=Fitzner|first1=D|last2=Simons|first2=M|date=2010|title=Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies|journal=Current Neuropharmacology|volume=8|issue=3|pages=305–315|doi=10.2174/157015910792246218|issn=1570-159X|pmc=3001222|pmid=21358979}}</ref>
* [[다계통 위축증]]<ref>{{저널 인용|last1=Ubhi|first1=K|last2=Low|first2=P|last3=Masliah|first3=E|date=2011|title=Multiple System Atrophy: A Clinical and Neuropathological Perspective|journal=Trends in Neurosciences|volume=34|issue=11|pages=581–590|doi=10.1016/j.tins.2011.08.003|issn=0166-2236|pmc=3200496|pmid=21962754}}</ref>
* [[근이영양증]] (MD)<ref>{{저널 인용|last1=Shin|first1=J|last2=Tajrishi|first2=MM|last3=Ogura|first3=Y|last4=Kumar|first4=A|date=2013|title=Wasting Mechanisms in Muscular Dystrophy|journal=The International Journal of Biochemistry & Cell Biology|volume=45|issue=10|pages=2266–2279|doi=10.1016/j.biocel.2013.05.001|issn=1357-2725|pmc=3759654|pmid=23669245}}</ref>
* [[신경원성 세로이드 리포푸신증]]<ref>{{서적 인용|last1=Mole|first1=SE|title=Neuronal Ceroid-Lipofuscinoses|date=1993|url=https://www.ncbi.nlm.nih.gov/books/NBK1428/|work=GeneReviews®|editor-last=Adam|editor-first=Margaret P.|publisher=University of Washington, Seattle|pmid=20301601|access-date=2018-09-17|last2=Williams|first2=Ruth E.|chapter=Neuronal Ceroid-Lipofuscinoses – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY |editor2-last=Ardinger|editor2-first=Holly H.|editor3-last=Pagon|editor3-first=Roberta A.|editor4-last=Wallace|editor4-first=Stephanie E.}}</ref>
* [[니만픽병]]s<ref>{{저널 인용|last1=Evans|first1=WRH|last2=Hendriksz|first2=CJ|date=2017|title=Niemann–Pick type C disease – the tip of the iceberg? A review of neuropsychiatric presentation, diagnosis and treatment|journal=BJPsych Bulletin|volume=41|issue=2|pages=109–114|doi=10.1192/pb.bp.116.054072|issn=2056-4694|pmc=5376728|pmid=28400970}}</ref>
* [[뼈관절염]]<ref name=":1">{{저널 인용|last1=Shen|first1=Y|last2=Zhang|first2=Y|last3=Shen|first3=L|date=2013-04-15|title=Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla|journal=BMC Musculoskeletal Disorders|volume=14|pages=136|doi=10.1186/1471-2474-14-136|issn=1471-2474|pmc=3659090|pmid=23587336|doi-access=free}}</ref>
* [[골다공증]]<ref name=":1" />
* [[파킨슨병]]<ref name=":0" />
* [[폐고혈압]]<ref>{{저널 인용|last1=Bazan|first1=IS|last2=Fares|first2=WH|date=2015-08-17|title=Pulmonary hypertension: diagnostic and therapeutic challenges|journal=Therapeutics and Clinical Risk Management|volume=11|pages=1221–1233|doi=10.2147/TCRM.S74881|issn=1176-6336|pmc=4544628|pmid=26316767 |doi-access=free }}</ref>
* 모든 [[프라이온 질환]] ([[크로이츠펠트-야콥병]], [[치사성 불면증]] 등)<ref name=":0" />
* [[진행성핵상성 마비]]<ref>{{저널 인용|last=Owolabi|first=LF|date=2013|title=Progressive Supranuclear Palsy Misdiagnosed as Parkinson's Disease: A Case Report and Review of Literature|journal=Annals of Medical and Health Sciences Research|volume=3|issue=Suppl1|pages=S44–S47|doi=10.4103/2141-9248.121221|issn=2141-9248|pmc=3853608|pmid=24349849 |doi-access=free }}</ref>
* [[망막색소변성증]] (RP)<ref>{{저널 인용|last=Hamel|first=C|date=2006-10-11|title=Retinitis pigmentosa|journal=Orphanet Journal of Rare Diseases|volume=1|pages=40|doi=10.1186/1750-1172-1-40|issn=1750-1172|pmc=1621055|pmid=17032466|doi-access=free}}</ref>
* [[류마티스 관절염]]<ref>{{저널 인용|last1=Abdel-Ahad|first1=P|last2=El Chammai|first2=M|last3=Fneich|first3=A|last4=Issa|first4=R|last5=Kabbara|first5=W|last6=Richa|first6=S|date=2016|title=Les manifestations psychiatriques dans la polyarthrite rhumatoïde|journal=L'Encéphale|volume=42|issue=2|pages=172–176|doi=10.1016/j.encep.2015.12.008|pmid=26850214|issn=0013-7006}}</ref>
* [[샌드호프병]]<ref name=":2">{{저널 인용|last1=Walia|first1=JP|last2=Altaleb|first2=N|last3=Bello|first3=A|last4=Kruck|first4=C|last5=LaFave|first5=MC|last6=Varshney|first6=GK|last7=Burgess|first7=SM|last8=Chowdhury|first8=B|last9=Hurlbut|first9=D|date=2015|title=Long-Term Correction of Sandhoff Disease Following Intravenous Delivery of rAAV9 to Mouse Neonates|journal=Molecular Therapy|volume=23|issue=3|pages=414–422|doi=10.1038/mt.2014.240|issn=1525-0016|pmc=4351464|pmid=25515709}}</ref>
* [[척수성 근위축증]] (SMA, 운동뉴런 질환)<ref>{{저널 인용|last1=Simone|first1=C|last2=Ramirez|first2=A|last3=Bucchia|first3=M|last4=Rinchetti|first4=P|last5=Rideout|first5=H|last6=Papadimitriou|first6=D|last7=Re|first7=DB|last8=Corti|first8=S|date=2016|title=Is Spinal Muscular Atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?|journal=Cellular and Molecular Life Sciences|volume=73|issue=5|pages=1003–1020|doi=10.1007/s00018-015-2106-9|issn=1420-682X|pmc=4756905|pmid=26681261}}</ref>
* [[아급성 경화 범뇌염]]<ref>{{저널 인용|last1=Jafri|first1=SK|last2=Kumar|first2=R|last3=Ibrahim|first3=SH|date=2018-06-26|title=Subacute sclerosing panencephalitis – current perspectives|journal=Pediatric Health, Medicine and Therapeutics|volume=9|pages=67–71|doi=10.2147/PHMT.S126293|issn=1179-9927|pmc=6027681|pmid=29985487 |doi-access=free }}</ref>
* [[약물 사용 장애]]<ref>{{웹 인용|url=https://www.hazeldenbettyford.org/education/bcr/addiction-research/brain-disease-model-ru-316#:~:text=Patients%3A%20Addiction%20is%20a%20degenerative,be%20reversed%20through%20sustained%20abstinence. |url-status=dead |archive-url=https://web.archive.org/web/20171027170151/http://www.hazeldenbettyford.org/education/bcr/addiction-research/brain-disease-model-ru-316 |archive-date=2017-10-27 |title=Brain Disease Model of Drug & Alcohol Addiction {{!}} Hazelden Betty Ford}}</ref>
* [[테이-삭스병]]<ref name=":2" />
* [[혈관성 치매]] (그 자체로는 신경퇴행성 치매가 아닐 수 있지만 종종 다른 형태의 퇴행성 치매와 함께 나타난다.)<ref>{{저널 인용|last1=Korczyn|first1=AD|last2=Vakhapova|first2=V|last3=Grinberg|first3=LT|date=2012-11-15|title=Vascular dementia|journal=Journal of the Neurological Sciences|volume=322|issue=1–2|pages=2–10|doi=10.1016/j.jns.2012.03.027|issn=0022-510X|pmc=3435447|pmid=22575403}}</ref>
{{col div end}}

== 같이 보기 ==
* [[수명 연장]]
* [[생물학적 노화]]
* [[진행성 질환]]
* [[유전 질환 목록]]

== 각주 ==
{{각주}}

{{전거 통제}}

[[분류:질병]]
[[분류:노쇠]]
[[분류:노화 과정]]