{{위키데이터 속성 추적}}
{{번역 확장 필요|en|Finasteride}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 458461973
| IUPAC_name = (1S,3aS,3bS,5aR,9aR,9bS,11aS)-''N''-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
| image = Finasteride.svg
| width = 200px
| image2 = Finasteride-3D-balls.png
| width2 = 250px

<!--Clinical data-->
| tradename = 프로스카(Proscar), 프로페시아(Propecia) 등
| Drugs.com = {{drugs.com|monograph|finasteride}}
| MedlinePlus = a698016
| pregnancy_category = X (선천성 결함을 일으킬 수 있음)
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = [[구강 투여|구강]]
| class = [[5α 환원 효소 억제제]]

<!--Pharmacokinetic data-->
| bioavailability = 65%<ref name="LemkeWilliams2008">{{서적 인용|author1=Thomas L. Lemke|author2=David A. Williams|title=Foye's Principles of Medicinal Chemistry|url=https://books.google.com/books?id=R0W1ErpsQpkC&pg=PA1286|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-6879-5|pages=1286-}}</ref>
| protein_bound = 90%<ref name="LemkeWilliams2008" />
| metabolism = [[간]] ([[CYP3A4]])<ref name="LemkeWilliams2008" />
| elimination_half-life = 성인: 5-6시간<ref name="LemkeWilliams2008" /><br />노인: >8 시간<ref name="LemkeWilliams2008" />
| excretion = [[똥]]: 57%<ref name="LemkeWilliams2008" /><br />[[오줌]]: 40%<ref name="LemkeWilliams2008" />

<!--Identifiers-->
| IUPHAR_ligand = 6818
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 98319-26-7
| ATC_prefix = G04
| ATC_suffix = CB01
| ATC_supplemental = {{ATC|D11|AX10}}
| PubChem = 57363
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
 | DrugBank = DB01216
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 51714
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 57GNO57U7G
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00321
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 5062
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 710
| synonyms = MK-906; L-652,931; 17β-(''N''-tert-Butylcarbamoyl)-4-aza-5α-androst-1-en-3-one; ''N''-(1,1-Dimethylethyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide

<!--Chemical data-->
| C=23 | H=36 | N=2 | O=2
| molecular_weight = 372.549 g/mol
| SMILES = O=C(NC(C)(C)C)[C@@H]2[C@]1(CC[C@H]3[C@H]([C@@H]1CC2)CC[C@H]4NC(=O)\C=C/[C@]34C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = DBEPLOCGEIEOCV-WSBQPABSSA-N
}}

'''피나스테리드'''(Finasteride)는 '''프로스카'''(Proscar), '''프로페시아'''(Propecia) 등의 제품명으로 판매되는 [[전립선비대증]]이나 [[남성형 탈모]]를 치료하기 위해 주로 사용되는 약물이다.<ref name="Drugs.com">https://www.drugs.com/international/finasteride.html</ref><ref name="Buckingham1987">{{서적 인용| first = J. | last = Buckingham | name-list-format = vanc | title = Dictionary of Organic Compounds | url = https://books.google.com/books?id=x2Su3GKCvtsC&pg=PA3162 | year = 1987 | publisher = CRC Press | isbn = 978-0-412-54090-5 | page = 3147 }}</ref><ref name="MortonHall2012">{{서적 인용| first1 = I.K. | last1 = Morton | first2 = Judith M. | last2 = Hall | name-list-format = vanc | title = Concise Dictionary of Pharmacological Agents: Properties and Synonyms | url = https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA121 | date = 6 December 2012 | publisher = Springer Science & Business Media | isbn = 978-94-011-4439-1 | pages = 121, 246 }}</ref> 여성의 [[조모증]] 치료를 위해, 또 [[트랜스여성]]의 [[호르몬 대체요법 (MTF)|호르몬 치료]]의 일부로서 사용되기도 한다.<ref name="Blume-PeytaviWhiting2008">{{서적 인용| first1 = Ulrike | last1 = Blume-Peytavi | first2 = David A. | last2 = Whiting | first3 = Ralph M. | last3 = Trüeb | name-list-format = vanc | title = Hair Growth and Disorders | url = https://books.google.com/books?id=pHrX2-huQCoC&pg=PA369 | date = 26 June 2008 | publisher = Springer Science & Business Media | isbn = 978-3-540-46911-7 | pages = 369 }}</ref><ref name="TranssexualMgmnt2012">{{저널 인용| vauthors = Knezevich EL, Viereck LK, Drincic AT | title = Medical management of adult transsexual persons | journal = Pharmacotherapy | volume = 32 | issue = 1 | pages = 54–66 | date = January 2012 | pmid = 22392828 | doi = 10.1002/PHAR.1006 }}</ref> [[구강 투여|구강]]을 통해 투여된다.<ref name="ProscarLabel">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020180s037lbl.pdf Proscar label]</ref>

[[부가작용|부작용]]은 일반적으로 온화한 편이다.<ref name="Cochrane2010">{{저널 인용| vauthors = Tacklind J, Fink HA, Macdonald R, Rutks I, Wilt TJ | title = Finasteride for benign prostatic hyperplasia | journal = The Cochrane Database of Systematic Reviews | issue = 10 | pages = CD006015 | date = October 2010 | pmid = 20927745 | doi = 10.1002/14651858.CD006015.pub3 }}</ref> 특정한 희귀 형태의 [[전립선암]]을 증가시킬 수 있으며 일부 남성들은 [[성 기능 장애]], [[우울증]], [[불안]], [[여성형유방증|가슴 비대]]를 경험할 수 있다. 성 기능 이상은 매우 고통스러울 수 있다.<ref name="2014AArev">{{저널 인용| vauthors = Varothai S, Bergfeld WF | title = Androgenetic alopecia: an evidence-based treatment update | journal = American Journal of Clinical Dermatology | volume = 15 | issue = 3 | pages = 217–30 | date = July 2014 | pmid = 24848508 | doi = 10.1007/s40257-014-0077-5 }}</ref> 피나스테리드는 [[5α 환원 효소 억제제]]로서 [[전립샘]]과 [[두피]]와 같은 인체의 일부분에서 [[안드로겐]] [[성호르몬]]인 [[디하이드로테스토스테론]](DHT)의 [[생합성|합성]]을 [[효소 억제제|억제]]함으로써 동작한다.<ref name="pmid19879888">{{저널 인용| vauthors = Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M | title = An overview on 5alpha-reductase inhibitors | journal = Steroids | volume = 75 | issue = 2 | pages = 109–53 | date = February 2010 | pmid = 19879888 | doi = 10.1016/j.steroids.2009.10.005 }}</ref> 3가지 [[아이소자임|형태]]의 [[5α 환원 효소]] 중 2가지를 [[효소 억제제|억제]]하며 혈중 DHT 수준을 최대 70%까지 떨어트릴 수 있다.<ref name="LemkeWilliams2008" /><ref name="Yamana2010">{{저널 인용| vauthors = Yamana K, Labrie F, Luu-The V | title = Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride | journal = Hormone Molecular Biology and Clinical Investigation | volume = 2 | issue = 3 | pages = 293–9 | date = August 2010 | pmid = 25961201 | doi = 10.1515/hmbci.2010.035 }}</ref><ref name="pmid10765065">{{저널 인용| vauthors = Bartsch G, Rittmaster RS, Klocker H | title = Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia | journal = European Urology | volume = 37 | issue = 4 | pages = 367–80 | date = April 2000 | pmid = 10765065 | doi = 10.1159/000020181 }}</ref>

피나스테리드는 1992년 전랍선 비대 치료를 위해 도입되었으며 1997년 탈모 치료를 위해 승인되었다.<ref name="BurgerAbraham2003">{{서적 인용|author1=Alfred Burger|author2=Donald J. Abraham|title=Burger's Medicinal Chemistry and Drug Discovery, Autocoids, Diagnostics, and Drugs from New Biology|url=https://books.google.com/books?id=25ZUAAAAMAAJ|date=20 February 2003|publisher=Wiley|isbn=978-0-471-37030-7|page=439}}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://www.proscar.com/ Proscar | Official website]
* [http://www.propecia.com Propecia | Official website] {{웨이백|url=http://www.propecia.com/ |date=20070224181139 }}

{{전거 통제}}

[[분류:5α-환원 효소 억제제]]
[[분류:안드로스탄]]
[[분류:카복사마이드]]
[[분류:제모]]
[[분류:델타-락탐]]
[[분류:트랜스젠더와 의학]]
[[분류:기형 유발 물질]]