{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 451110455
| IUPAC_name = 
| image = Lentinan.svg
| width = 300px
<!-- Clinical data -->
| tradename =  
| Drugs.com = {{drugs.com|international|lentinan}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category =  
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status =  
| routes_of_administration =
<!-- Pharmacokinetic data -->
| bioavailability =  
| protein_bound =  
| metabolism =  
| elimination_half-life =  
| excretion =
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 37339-90-5
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6751655D1D
| ATC_prefix = L03
| ATC_suffix = AX01
| ChEBI = 31770
| PubChem = 
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =  
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01695
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = none
<!-- Chemical data -->
| molecular_weight = ~ 500,000 Da
| synonyms = 
}}

'''렌티난'''({{llang|en|lentinan}})은 [[표고버섯]](''Lentinula edodes'')의 [[자실체]]로부터 분리된 [[다당류]]이다.

== 화학 ==
렌티난은 β-1,6 가지를 가지고 있는 β-1,3 [[베타-글루칸]]이다. 렌티난의 분자량은 500,000 Da이고 비선도는 +14~22° (NaOH)이다.

== 연구 ==
=== 전임상 연구 ===
[[생체외|체외]] 실험에서 렌티난이 사람의 세포주 [[U937 (세포주)|U937]]에서 [[백혈구]]의 생성을 촉진하는 것으로 나타났다.<ref name="pmid = 10190187 ">{{저널 인용
|author1=Sia GM |author2=Candlish JK | title = Effects of shiitake (''Lentinus edodes'') extract on human neutrophils and the U937 monocytic cell line
| journal = Phytotherapy Research
| volume = 13
| issue = 2
| pages = 133–7
| date=Mar 1999
| doi = 10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O
| pmid = 10190187
| doi-access = free
}}</ref> 렌티난은 경구 투여시 사람에서 비활성인 것으로 생각되므로 [[정맥 주사]]로 투여한다. 렌티난에 대한 [[생체 내]] 연구의 저자는 이 화합물이 쥐에 경구 투여되었을 때 활성을 나타낼 수 있다고 제안했다.<ref name="pmid = 12470439">{{저널 인용
|author1=Ng ML |author2=Yap AT | title =  Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (''Lentinus edodes'')
| journal = Journal of Alternative and Complementary Medicine
| volume = 8
| issue = 5
| pages = 581–9
| location = National University of Singapore
| date=Oct 2002
| doi = 10.1089/107555302320825093
| pmid = 12470439
}}</ref>

=== 사람에 대한 임상 시험 ===
렌티난은 [[일본]]에서 [[암]] 환자에 대한 제한된 수의 임상 연구의 대상이었다.<ref name="pmid = 18670743">{{저널 인용
|author1=Yang P |author2=Liang M |author3=Zhang Y |author4=Shen B | title =  Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC
| journal =  Advances in Therapy
| volume = 25
| issue = 8
| pages = 787–94
| date=Aug 2008
| doi = 10.1007/s12325-008-0079-x
| pmid = 18670743
|s2cid=33140754 }}</ref><ref name="pmid = 16897983">{{저널 인용
| author1 = Nimura H | author2 = Mitsumori N | author3 = Takahashi N |display-authors=etal
| title = [S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]
| journal =  Gan to Kagaku Ryoho
| volume = 33
| issue = 1
| pages = 106–9
| date=Jun 2006
| pmid = 16897983
| language = ja
}}</ref><ref name="pmid = 10522061">{{저널 인용
|author1=Nakano H |author2=Namatame K |author3=Nemoto H |author4=Motohashi H |author5=Nishiyama K |author6=Kumada K. | title =  A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.
| journal =  Hepatogastroenterology
| volume = 46
| issue = 28
| pages = 2662–8
| year = 1999
| pmid = 10522061
}}</ref><ref name="pmid19596954">{{저널 인용|vauthors=Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J |title=Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer |journal=Anticancer Research |volume=29 |issue=7 |pages=2739–45 |date=July 2009 |pmid=19596954 }}</ref><ref name="pmid19596936">{{저널 인용|vauthors=Hazama S, Watanabe S, Ohashi M, etal |title=Efficacy of Orally Administered Superfine Dispersed Lentinan (β-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer |journal=Anticancer Research |volume=29 |issue=7 |pages=2611–2617 |date=July 2009 |pmid=19596936 |url=http://ar.iiarjournals.org/content/29/7/2611.full}}</ref><ref name="pmid19579640">{{저널 인용|vauthors=Kataoka H, Shimura T, Mizoshita T, etal |title=Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life |journal=Hepatogastroenterology |volume=56 |issue=90 |pages=547–50 |year=2009 |pmid=19579640 }}</ref><ref name="pmid19579616">{{저널 인용|vauthors=Isoda N, Eguchi Y, Nukaya H, etal |title=Clinical efficacy of superfine dispersed lentinan (β-1,3-glucan) in patients with hepatocellular carcinoma |journal=Hepatogastroenterology |volume=56 |issue=90 |pages=437–41 |year=2009 |pmid=19579616 }}</ref><ref name="pmid19453066">{{저널 인용|vauthors=Shimizu K, Watanabe S, Watanabe S, etal |title=Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer |journal=Hepatogastroenterology |volume=56 |issue=89 |pages=240–4 |year=2009 |pmid=19453066 }}</ref> 그러나 [[효능]]에 대한 증거가 부족했다.<ref name="webmd">{{웹 인용|url=http://www.webmd.com/vitamins-supplements/ingredientmono-763-lentinan.aspx?activeingredientid=763&activeingredientname=lentinan|title=Lentinan|publisher=WebMD|access-date=June 10, 2017}}</ref><ref name="MSKCC">{{웹 인용|url=https://www.mskcc.org/cancer-care/integrative-medicine/herbs/lentinan|title=Lentinan|publisher=Memorial Sloan Kettering Cancer Center|access-date=June 10, 2017}}</ref>

=== 부작용 ===
덜 익힌 표고버섯을 먹었을 때, 렌티난이 [[표고버섯 피부염]]을 일으키는 것으로 보고되었다.<ref name="Nakamura">{{저널 인용|last1=Nakamura|first1=T|title=Shiitake (''Lentinus edodes'') dermatitis|journal=Contact Dermatitis|date=1992|volume=27|issue=2|pages=65–70|pmid=1395630|doi=10.1111/j.1600-0536.1992.tb05211.x|s2cid=7320474|doi-access=free}}</ref>

== 같이 보기 ==
* [[약용 균류]]

== 각주 ==
{{각주|30em}}

== 외부 링크 ==
* [https://www.drugs.com/npp/lentinan.html Lentinan] effects (antitumor and others)
* Memorial Sloan-Kettering Cancer Center's page for [http://www.mskcc.org/mskcc/html/69279.cfm Lentinan].

{{탄수화물}}

[[분류:면역 자극제]]
[[분류:다당류]]