{{위키데이터 속성 추적}}
{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477223250
| ImageFile=4-phenyl-1-(4-phenylbutyl) piperidine.svg
| ImageSize=250
| ImageAlt = Skeletal formula of 4-PPBP
| ImageFile1 = 4-PPBP-3D-balls.png
| ImageSize1 = 250
| ImageAlt1 = Ball-and-stick model of the 4-PPBP molecule
| IUPACName=4-phenyl-1-(4-phenylbutyl) piperidine
| OtherNames=
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2299855
| InChI = 1/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
| InChIKey = HQGDPZPNAXRCSA-UHFFFAOYAV
| SMILES1 = c1ccccc1C3CCN(CCCCc2ccccc2)CC3
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 325238
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = HQGDPZPNAXRCSA-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=136534-70-8
| PubChem=3035672
| SMILES = C1CN(CCC1C2=CC=CC=C2)CCCCC3=CC=CC=C3
| MeSHName=4-phenyl-1-(4-phenylbutyl)piperidine
  }}
|Section2={{Chembox Properties
| Formula =
| C=21 | H=27 | N=1 
| MolarMass=293.446 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
  }}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
  }}
}}
'''4-PPBP''' 또는 '''4-페닐-1-(4-페닐뷰틸) 피페리딘'''({{llang|en|4-phenyl-1-(4-phenylbutyl) piperidine}})은 [[시그마 수용체]]에 결합하는 [[분자]]이다.<ref>{{저널 인용| vauthors = Yang S, Bhardwaj A, Cheng J, Alkayed NJ, Hurn PD, Kirsch JR | title = Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2 | url = https://archive.org/details/sim_anesthesia-and-analgesia_2007-05_104_5/page/1179 | journal = Anesthesia and Analgesia | volume = 104 | issue = 5 | pages = 1179–84, tables of contents | date = May 2007 | pmid = 17456670 | pmc = 2596726 | doi = 10.1213/01.ane.0000260267.71185.73 }}</ref>

4-PPBP는 뉴런의 산화 질소 생성효소의 활성 및 허혈을 유발하는 [[일산화 질소|산화 질소]](NO)의 생성을 감소시킨다. 4-PPBP는 신경보호를 제공하고, 이것은 허혈을 유도하는 세포 내 Ca<sup>2+</sup> 조절 이상을 방지하는 것을 포함한다.<ref>{{저널 인용| vauthors = Yang ZJ, Carter EL, Torbey MT, Martin LJ, Koehler RC | title = Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons | journal = Experimental Neurology | volume = 221 | issue = 1 | pages = 166–74 | date = January 2010 | pmid = 19883643 | pmc = 2812675 | doi = 10.1016/j.expneurol.2009.10.019 }}</ref> 4-PPBP는 전사인자인 고리형 아데노신 일인산 반응요소 결합단백질(CREB)을 활성화시키는 기작을 사용하여 뉴런을 보호한다. 4-PPBP와 관련된 신경보호는 Bcl-2의 발현을 증가시킨다. Bcl-2의 발현은 CREB에 의해 조절된다.<ref>{{저널 인용| vauthors = Yang S, Alkayed NJ, Hurn PD, Kirsch JR | title = Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) | url = https://archive.org/details/sim_anesthesia-and-analgesia_2009-03_108_3/page/964 | journal = Anesthesia and Analgesia | volume = 108 | issue = 3 | pages = 964–70 | date = March 2009 | pmid = 19224810 | pmc = 2828492 | doi = 10.1213/ane.0b013e318192442c }}</ref>

== 같이 보기 ==
* [[3-PPP]]

== 각주 ==
{{각주}}

[[분류:피페리딘]]
[[분류:시그마 작용제]]
[[분류:4-페닐피페리딘]]