{{위키데이터 속성 추적}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 411878260
| IUPAC_name = ''N''-<nowiki>[1-[[1-[[1-[[1-[[1-[[1-[[5-</nowiki>(diaminomethylideneamino)-1-<br />[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxo-pentan-2-<br />yl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-<br />butyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]<br />carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1''H''-indol-3-<br />yl)ethyl]carbamoyl]-2-(3''H''-imidazol-4-yl)ethyl]-5-oxo-<br />pyrrolidine-2-carboxamide
| image = Leuprorelin.svg
| width = 250px
| image2 = Leuprorelin ball-and-stick.png
| width2 = 250px

<!--Clinical data-->
| tradename = Lupron, Eligard, Lucrin, others
| Drugs.com = {{drugs.com|monograph|leuprolide-acetate}}
| MedlinePlus = a685040
| pregnancy_category = X
| legal_status = Rx-only
| routes_of_administration = [[이식물|장치]], [[주사 (의학)|주사]]
| class = [[성선자극호르몬분비호르몬 작용제|GnRH 작용제]]; [[항고나도트로핀]]

<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 3시간
| excretion = [[콩팥]]

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 53714-56-0
| CAS_supplemental = <br/>{{CAS|74381-53-6}} ([[아세트산염]])
| ATC_prefix = L02
| ATC_suffix = AE02
| PubChem = 657181
| IUPHAR_ligand = 1175
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00007
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = EFY6W0M8TG
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08113
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201199
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 571356
| synonyms = Leuprolide; Leuprolidine; A-43818; Abbott-43818; DC-2-269; TAP-144

<!--Chemical data-->
| C=59 | H=84 | N=16 | O=12
| SMILES = CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4c3cccc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = GFIJNRVAKGFPGQ-LIJARHBVSA-N
}}
<!-- Definition and medical uses -->
'''류프로렐린'''(Leuprorelin, 상표명: 루프론)은 [[전립선암]], [[유방암]], [[자궁내막증]], [[자궁근종]], [[성조숙증]] 등에 쓰이는 약물이다.<ref name=AHFS2016>{{웹 인용|title=Leuprolide Acetate|url=https://www.drugs.com/monograph/leuprolide-acetate.html|publisher=The American Society of Health-System Pharmacists|accessdate=8 December 2016|url-status=live|archiveurl=https://web.archive.org/web/20161223133754/https://www.drugs.com/monograph/leuprolide-acetate.html|archivedate=23 December 2016}}</ref><ref name=WHO2015E>{{웹 인용|url=http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf |title=19th WHO Model List of Essential Medicines (April 2015) |date=April 2015 |accessdate=May 10, 2015 |publisher=WHO |url-status=live |archiveurl=https://web.archive.org/web/20150513043105/http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf |archivedate=May 13, 2015 }}</ref> 흔한 [[부작용]]으로는 [[열성 홍조]], 기분 변화, [[불면]] 증상, [[두통]] 등이 있으며, [[고혈당]], [[알러지|알러지 반응]], 뇌하수체 경색 등의 [[시상하부]] 및 [[뇌하수체]] 상태변화 등이 있다.<ref name=AHFS2016/> [[임신]] 중 류프로렐린 사용은 [[태아]]에게 위해를 가할 수 있다.<ref name=AHFS2016/>

류프로렐린은 [[성선자극호르몬분비호르몬 유사체|GnRH 유사체]]에 속하며, [[뇌하수체]]의 [[성선자극호르몬분비호르몬 수용체|GnRH 수용체]]에서 [[성선자극호르몬분비호르몬 작용제|GnRH 작용제]] 및 [[항고나도트로핀]]으로 작용하여 [[성선자극호르몬]]을 감소시키고 결과적으로 [[테스토스테론]] 및 [[에스트라디올]] 분비를 줄인다.<ref name = AHFS2016 />

== 같이 보기 ==
* [[성선자극호르몬분비호르몬 작용제]]

== 각주 ==
{{각주}}

{{토막글|의학}}

[[분류:호르몬성 항암제]]
[[분류:펩타이드]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:애브비의 제품]]
[[분류:세계 반도핑 기구 금지 약물]]