{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 457797273
| IUPAC_name =Methyl (5-benzoyl-1''H''-benzimidazol-2-yl)carbamate
| image = Mebendazole.svg
| width = 225

<!--Clinical data-->
| tradename = Vermox<ref>{{서적 인용|last1=Ebadi|first1=Manuchair|title=Desk reference of clinical pharmacology|date=2008|publisher=CRC Press|location=Boca Raton|isbn=9781420047448|page=403|edition=2|url=https://books.google.com/books?id=ihxyHbnj3qYC&pg=PA403|url-status=live|archiveurl=https://web.archive.org/web/20170908140525/https://books.google.com/books?id=ihxyHbnj3qYC&pg=PA403|archivedate=2017-09-08}}</ref>
| Drugs.com = {{drugs.com|monograph|mebendazole}}
| MedlinePlus = a682315
| pregnancy_AU = B3
| pregnancy_US = C
| legal_AU = S2
| legal_CA = OTC
| legal_UK = POM
| legal_UK_comment = /P<ref>{{웹 인용 |url=http://www.evidence.nhs.uk/formulary/bnf/current/5-infections/55-anthelmintics/551-drugs-for-threadworms/mebendazole |title=MEBENDAZOLE |accessdate=2016-04-29 |url-status=dead |archiveurl=https://web.archive.org/web/20161023152521/http://www.evidence.nhs.uk/formulary/bnf/current/5-infections/55-anthelmintics/551-drugs-for-threadworms/mebendazole |archivedate=2016-10-23 }}</ref>
| legal_US = Rx-only
| routes_of_administration = [[:en:Oral administration|By mouth]]

<!--Pharmacokinetic data-->
| bioavailability = 2–10%
| protein_bound = 95%
| metabolism = Extensive [[간]]
| elimination_half-life = 3–6 hours
| excretion = Faeces, urine (5–10%)

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 31431-39-7
| ATC_prefix = P02
| ATC_suffix = CA01
| ATC_supplemental = {{ATCvet|P52|AC09}}
| PubChem = 4030
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00643
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3890
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 81G6I5V05I
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00368
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6704
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 685

<!--Chemical data-->
| C=16 | H=13 | N=3 | O=3
| smiles = COC(=O)Nc3nc2ccc(C(=O)c1ccccc1)cc2[nH]3
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = OPXLLQIJSORQAM-UHFFFAOYSA-N
| melting_point = 288.5
}}

'''메벤다졸'''({{lang|en|mebendazole}}, '''MBZ''')은 수많은 [[기생충]] 감염을 치료하기 위해 사용되는 약물이다.<ref name=AHFS2015/> 여기에는 [[회충증]], [[요충병]], [[십이지장충]], [[메디나충증|메디나충증 감염]], [[포충증]], [[선모충속|선모충]]<ref>{{저널 인용|제목=Clinical Update on Parasitic Diseases|저널=The Korean Journal of Medicine|성=Seo|이름=Min|url=http://www.ekjm.org/journal/view.php?number=24009|날짜=2013-11-01|권=85|호=5|쪽=469–480|언어=영어|doi=10.3904/kjm.2013.85.5.469|issn=1738-9364}}</ref>, [[편모충증]] 등이 포함된다.<ref name=AHFS2015/> 구강으로 섭취된다.<ref name=AHFS2015>{{웹 인용|title=Mebendazole|url=https://www.drugs.com/monograph/mebendazole.html|publisher=The American Society of Health-System Pharmacists|accessdate=Aug 18, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150907003126/http://www.drugs.com/monograph/mebendazole.html|archivedate=2015-09-07}}</ref>

메벤다졸은 내성이 좋은 편이다.<ref name=AHFS2015/> 일반적인 부작용으로는 [[두통]], 구토, [[귀울림]]이 포함된다.<ref name=AHFS2015/> 다량을 복용하면 [[골수 억제]]를 유발할 수 있다.<ref name=AHFS2015/> 임신 중에 복용해도 안전한지는 분명하지 않다.<ref name=AHFS2015/> 메벤다졸은 폭넓은 효능을 지닌 [[벤즈이미다졸]]형 [[구충제]]이다.<ref name=AHFS2015/>

메벤다졸은 [[벨기에]]의 [[얀센 제약]]이 개발한 이후 1971년 사용이 시작되었다.<ref>{{서적 인용|last1=Mehlhorn|first1=Heinz|title=Encyclopedic reference of parasitology. 107 tables|date=2001|publisher=Springer|location=Berlin [u.a.]|isbn=9783540668299|page=259|edition=2|url=https://books.google.com/books?id=OBZbR4vpg0YC&pg=PA259|url-status=live|archiveurl=https://web.archive.org/web/20170908140525/https://books.google.com/books?id=OBZbR4vpg0YC&pg=PA259|archivedate=2017-09-08}}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016}}</ref> 메벤다졸은 [[제네릭 의약품]]으로 구매가 가능하다.<ref name=Ric2012>{{서적 인용|last1=Hamilton|first1=Richard J.|title=Tarascon pocket pharmacopoeia|date=2012|publisher=Jones & Bartlett Learning|location=Burlington, Mass.|isbn=9781449624286|page=33|edition=13|url=https://books.google.com/books?id=BmKOS-b0s08C&pg=PA355|url-status=live|archiveurl=https://web.archive.org/web/20170908140524/https://books.google.com/books?id=BmKOS-b0s08C&pg=PA355|archivedate=2017-09-08}}</ref> [[개발도상국]]의 도매가는 도스(dose) 당 0.004 ~ 0.04 USD 사이이다.<ref name=GlobP2014>{{웹 인용|title=Mebendazole|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=493&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=18 August 2015|url-status=live|archiveurl=https://web.archive.org/web/20170305003745/http://mshpriceguide.org/en/single-drug-information/?DMFId=493&searchYear=2014|archivedate=5 March 2017}}</ref> 미국내 일회량은 2016년 기준으로 대략 440.00 USD에 이르는 반면, 오스트레일리아와 영국에서의 가격은 대략 5 USD이다.<ref name=FT2016>{{뉴스 인용|last1=Crow|first1=David|title=US drugmaker charges 200 times UK price for common worm pill|url=https://www.ft.com/content/f0080fe4-c3ad-11e6-9bca-2b93a6856354|accessdate=8 January 2017|work=www.ft.com|date=18 December 2016|구독=yes|url-status=live|archiveurl=https://web.archive.org/web/20170108061742/https://www.ft.com/content/f0080fe4-c3ad-11e6-9bca-2b93a6856354|archivedate=8 January 2017}}</ref>

== 각주 ==
{{각주}}

[[분류:벨기에의 발명품]]
[[분류:카밤산염]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:벤즈이미다졸]]
[[분류:기형 유발 물질]]
[[분류:구충제]]
[[분류:방향족 케톤]]
[[분류:존슨앤드존슨의 제품]]
[[분류:얀센제약]]