{{위키데이터 속성 추적}}
{{Drugbox
| verifiedrevid = 477170896
| IUPAC_name = (''RS'')-9-methyl-3-[(2-methyl-1''H''-imidazol-1-yl)methyl]-2,3-dihydro-1''H''-carbazol-4(9''H'')-one
| drug_name =
| image = Ondansetron skeletal.svg
| width = 225
| image2 = Ondansetron 3D.png
| width2 = 250
<!--Clinical data-->
| tradename = Zofran, Ondisolv, others
| Drugs.com = {{drugs.com|monograph|ondansetron-hydrochloride}}
| MedlinePlus = a601209
| pregnancy_AU = B1
| pregnancy_US = B
| legal_AU = S4
| legal_CA = Rx-only
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = by mouth, [[좌약|rectal]], [[수액 (의학)|IV]], [[근육 주사|IM]]
<!--Pharmacokinetic data-->
| bioavailability = ~60%
| protein_bound = 70%-76%
| metabolism = [[간]] ([[CYP3A4]], [[CYP1A2]], [[CYP2D6]])
| elimination_half-life = 5.7 시간
| excretion = [[콩팥]]
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 99614-02-5
| ATC_prefix = A04
| ATC_suffix = AA01
| PubChem = 4595
| IUPHAR_ligand = 2290
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00904
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4434
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 4AF302ESOS
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00456
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 46
<!--Chemical data-->
| C=18 | H=19 | N=3 | O=1
| molecular_weight = 293.4 g/mol
| smiles = O=C3c2c1ccccc1n(c2CCC3Cn4ccnc4C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = FELGMEQIXOGIFQ-UHFFFAOYSA-N
}}
'''온단세트론'''(Ondansetron, 제품명: Zofran)은 [[화학요법|암 화학요법]], [[방사선종양학과|방사선 치료]], 수술에 의한 [[구역질]], [[구토]]를 예방하는데 사용되는 약물이다.<ref name=AHFS2016 /> [[장염]]에도 유용하게 사용될 수 있다.<ref>{{저널 인용|last1=Schnadower|first1=D|last2=Finkelstein|first2=Y|last3=Freedman|first3=SB|title=Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries.|journal=Current opinion in gastroenterology|date=January 2015|volume=31|issue=1|pages=1-6|pmid=25333367|doi=10.1097/mog.0000000000000132}}</ref><ref>{{저널 인용|last1=Freedman|first1=SB|last2=Ali|first2=S|last3=Oleszczuk|first3=M|last4=Gouin|first4=S|last5=Hartling|first5=L|title=Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries.|journal=Evidence-based child health : a Cochrane review journal|date=July 2013|volume=8|issue=4|pages=1123-37|pmid=23877938|doi=10.1002/ebch.1932}}</ref> [[멀미]]에 의한 구토에는 그다지 효력이 없다.<ref>{{저널 인용|last1=Sutton|first1=M|last2=Mounsey|first2=AL|last3=Russell|first3=RG|title=FPIN's Clinical Inquiries. Treatment of motion sickness.|journal=American family physician|date=15 July 2012|volume=86|issue=2|pages=192-5|pmid=22962932}}</ref> 구강, [[근육 주사]], [[수액 (의학)|수액]]을 통해 적용 가능하다.<ref name=AHFS2016>{{웹 인용|title=Ondansetron Hydrochloride|url=http://www.drugs.com/monograph/ondansetron-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|accessdate=February 11, 2017|archive-url=https://web.archive.org/web/20160503132329/http://www.drugs.com/monograph/ondansetron-hydrochloride.html|archive-date=May 3, 2016|url-status=live}}</ref>

온단세트론은 1990년에 의학적으로 처음 사용되었다.<ref>{{서적 인용|last1=Sneader|first1=Walter|title=Drug discovery : a history|date=2005|publisher=Wiley|location=Chichester|isbn=978-0-471-89979-2|page=217|edition=Rev. and updated|url=https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA217}}</ref> [[의료제도]]에 필수적인, 가장 효과적이고 안전한 약물이 기재된 [[WHO 필수 약물 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015}}</ref> [[제네릭 의약품]]으로 구매가 가능하다.<ref name=AHFS2016 />

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Ondansetron U.S. National Library of Medicine: Drug Information Portal - Ondansetron]

{{전거 통제}}
{{토막글|의학}}

[[분류:항구토제]]
[[분류:이미다졸]]
[[분류:케톤]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:5-HT3 길항제]]