{{위키데이터 속성 추적}}
{{Chembox
| Name = 베타-류신<br>β-Leucine
<!-- Images -->
| ImageFile = β-leucine.svg
| ImageSize = 150px
| ImageAlt =
<!-- Names -->
| IUPACName = 3-Amino-4-methylpentanoic acid
| OtherNames = <small>DL</small>-β-Leucine; Homovaline
<!-- Sections -->
| Section1 = {{Chembox Identifiers
| CASNo = 5699-54-7 
| PubChem = 2761558
| ChemSpiderID = 167837
| ChEBI = 15604
| KEGG = C02486
| 3DMet = B00449
| SMILES = CC(C)C(CC(=O)O)N
| InChI=1S/C6H13NO2/c1-4(2)5(7)3-6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)
| InChIKey=GLUJNGJDHCTUJY-UHFFFAOYSA-N
  }}
| Section2 = {{Chembox Properties
| C=6|H=13|N=1|O=2
| Appearance = 
| Density = 
| MeltingPt = 
| BoilingPt = 
| Solubility = 
  }}
| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
| GHSPictograms = {{GHS07}}
| GHSSignalWord = Warning
| HPhrases = {{H-phrases|315|319|335}}
| PPhrases = {{P-phrases|261|264|271|280|302+352|304+340|305+351+338|312|321|332+313|337+313|362|403+233|405|501}}
  }}
}}
'''β-류신'''({{llang|en|β-leucine}})은 [[류신|L-류신]]의 위치 이성질체로, [[류신 2,3-아미노뮤테이스]]에 의한 L-류신의 [[물질대사|대사]] 경로를 통해 사람에서 자연적으로 생성되는 β-아미노산이다.<ref name="Leucine metabolism" /><ref name="BRENDA leucine metabolism" /><ref name="HMDB β-Leucine" /> 코발라민([[비타민 B12|비타민 B<sub>12</sub>]]) 결핍증이 있는 사람의 [[혈장]]에서 β-류신의 농도가 높아진다.<ref name="HMDB β-Leucine">http://www.hmdb.ca/metabolites/HMDB03640</ref>

== 사람에서 생합성 및 대사 ==
L-류신 대사의 작은 부분(약 33%를 차지하는 [[고환]]을 제외한 모든 조직에서 5% 미만)은 처음에 [[류신 2,3-아미노뮤테이스]]에 의해 촉매되어 β-류신을 생성한다. β-류신은 일련의 효소들에 의해 [[β-케토아이소카프로산]], β-케토아이소카프로일-CoA를 거쳐 [[아세틸-CoA]]로 대사된다.<ref name="Leucine metabolism">{{서적 인용|vauthors=Kohlmeier M|title=Nutrient Metabolism: Structures, Functions, and Genes|date=May 2015|publisher=Academic Press|isbn=978-0-12-387784-0|pages=385–388|edition=2nd|section-url=https://books.google.com/books?id=aTQTAAAAQBAJ&pg=PA387&q=beta-hydroxy%20beta-methylbutyrate%20HMB#v=onepage|url=https://books.google.com/books?id=aTQTAAAAQBAJ&printsec=frontcover#v=onepage|accessdate=6 June 2016|section=Leucine|quote=Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours&nbsp;... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds|url-status=live|archiveurl=https://web.archive.org/web/20180322000056/https://books.google.com/books?id=aTQTAAAAQBAJ&printsec=frontcover#v=onepage|archivedate=22 March 2018|df=dmy-all}}<br />[https://books.google.com/books?id=aTQTAAAAQBAJ&pg=PA386#v=onepage&q&f=false Figure 8.57: Metabolism of {{smallcaps all|L}}-leucine] {{웹아카이브|url=https://web.archive.org/web/20180322000056/https://books.google.com/books?id=aTQTAAAAQBAJ&pg=PA386|date=22 March 2018}}</ref><ref name="BRENDA leucine metabolism">{{웹 인용|title=Leucine metabolism|url=http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg|website=BRENDA|publisher=Technische Universität Braunschweig|accessdate=12 August 2016|url-status=dead|archiveurl=https://web.archive.org/web/20160817213425/http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg|archivedate=2016-08-17|df=dmy-all}}</ref>

== 같이 보기 ==
* [[베타-케토아이소카프로산|β-케토아이소카프로산]]

== 각주 ==
{{각주}}

{{단백질비생성성 아미노산}}
{{아미노산 대사 중간생성물들}}

[[분류:아미노산]]
[[분류:비단백질성 아미노산]]