{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 443366456
| IUPAC_name = (2''R'')-2-acetamido-3-sulfanylpropanoic acid<ref>{{웹 인용|title=L-Cysteine, N-acetyl- - Compound Summary|url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=581|work=PubChem Compound|publisher=National Center for Biotechnology Information|accessdate=9 January 2012|location=USA|date=25 March 2005|at=Identification|url-status=live|archiveurl=https://web.archive.org/web/20140112235508/http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=581|archivedate=12 January 2014|df=dmy-all}}</ref>
| image = Acetylcysteine2DACS.svg
| width = 125
| image2 = Acetylcysteine 3D.png
| width2 =
| drug_name =
| caption =

<!-- Clinical data -->
| pronounce  = {{IPAc-en|ə|ˌ|s|iː|t|əl|ˈ|s|ɪ|s|t|i|iː|n}} and similar ({{IPAc-en|ə|ˌ|s|ɛ|t|əl|-|,_|ˌ|æ|s|ᵻ|t|əl|-|,_|-|t|iː|n}})
| tradename = Acetadote, Fluimucil, Mucomyst, others
| Drugs.com = {{drugs.com|monograph|acetylcysteine}}
| MedlinePlus =
| licence_EU = <!-- EMA requires brand name -->
| licence_US = Acetylcysteine
| DailyMedID = 5558a5f5-e821-473b-7d8a-5d33d09f0586
| pregnancy_AU = B2
| pregnancy_US = B
| legal_AU = S2
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_US = OTC
| legal_US_comment = (by mouth), Rx-only (IV, inhalation)
| routes_of_administration = By mouth, injection, inhalation

<!-- Pharmacokinetic data -->
| bioavailability = 10% (Oral)<ref>{{서적 인용| last1 = Stockley | first1 = Robert A. | name-list-format = vanc | title = Chronic Obstructive Pulmonary Disease a Practical Guide to Management. | date = 2008 | publisher = John Wiley & Sons | location = Chichester | isbn = 9780470755280 | page = 750 | url = https://books.google.com/books?id=y9li1geShyYC&pg=PA750 | url-status = live | archiveurl = https://web.archive.org/web/20170908143219/https://books.google.com/books?id=y9li1geShyYC&pg=PA750 | archivedate = 8 September 2017 | df = dmy-all }}</ref>
| protein_bound = 50 to 83%<ref name=AHFS2015/>
| metabolism = [[간]]<ref name=AHFS2015/>
| elimination_half-life = 5.6 hours<ref name=DMI>{{웹 인용|title=ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]|work=DailyMed|publisher=Cumberland Pharmaceuticals Inc.|date=June 2013|accessdate=8 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=472f158a-5ab9-4308-8e49-1116e6ea3d39|url-status=live|archiveurl=https://web.archive.org/web/20140113001430/http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=472f158a-5ab9-4308-8e49-1116e6ea3d39|archivedate=13 January 2014|df=dmy-all}}</ref>
| excretion = Renal (30%),<ref name=AHFS2015/> faecal (3%)

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 616-91-1
| CAS_supplemental =
| ATC_prefix = R05
| ATC_suffix = CB01
| ATC_supplemental = {{ATC|S01|XA08}} {{ATC|V03|AB23}}
| PubChem = 12035
| PubChemSubstance =
| IUPHAR_ligand =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB06151
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 11540
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = WYQ7N0BPYC
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00221
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 28939
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 600
| synonyms = ''N''-acetylcysteine; ''N''-acetyl-<small>L</small>-cysteine; NALC; NAC

<!-- Chemical data -->
| chemical_formula =
| C=5 | H=9 | Ag= | As= | Au= | B= | Bi= | Br= | Cl= | Co= | F= | Fe= | Gd= | I=
| K= | Mn= | N=1 | Na= | O=3 | P= | Pt= | S=1 | Sb= | Se= | Sr= | Tc= | Zn= | charge=
| molecular_weight = 163.195
| smiles            = C/C(=N/[C@@H](CS)C(=O)O)/O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_comment =
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI          = 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
| StdInChIKey       = PWKSKIMOESPYIA-BYPYZUCNSA-N
| density = 
| melting_point = 109
| melting_high = 110
| melting_notes =<ref name=sial>{{웹 인용|title=N-ACETYL-L-CYSTEINE Product Information |url=https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma-Aldrich/Product_Information_Sheet/a7250pis.pdf |website=Sigma |publisher=Sigma-aldrich |accessdate=9 November 2014 |url-status=dead |archiveurl=https://web.archive.org/web/20140611120709/http://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma-Aldrich/Product_Information_Sheet/a7250pis.pdf |archivedate=11 June 2014 }}</ref>
| boiling_point = 
| boiling_notes =
| solubility = 
| specific_rotation = +5° (c = 3% in water)<ref name=sial/>
}}

'''아세틸시스테인'''({{llang|en|acetylcysteine}}) 또는 '''''N''-아세틸시스테인'''({{llang|en|''N''-acetylcysteine}}), '''NAC''')은 [[아세트아미노펜]]의 과다복용을 치료하고 [[낭포성 섬유증]]이나 [[만성 폐쇄성 폐질환]] 환자의 고농도의 [[점액]]을 완화시키기 위해 사용되는 [[의약품]]이다.<ref name=AHFS2015>{{웹 인용|title=Acetylcysteine|url=https://www.drugs.com/monograph/acetylcysteine.html|publisher=The American Society of Health-System Pharmacists|accessdate=Aug 22, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150923231013/http://www.drugs.com/monograph/acetylcysteine.html|archivedate=23 September 2015|df=dmy-all}}</ref> [[수액 (의학)|정맥 주사]], 구강 또는 스프레이 형태의 흡입을 통해 투여할 수 있다.<ref name=AHFS2015/> 일부 사람들은 아세틸시스테인을 [[식이 보충제]]로 사용한다.<ref>{{서적 인용|last1=Talbott|first1=Shawn M.|title=A Guide to Understanding Dietary Supplements|date=2012|publisher=Routledge|isbn=9781136805707|page=469|url=https://books.google.com/books?id=9ZZrW_j9XrcC&pg=PA469|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170908143219/https://books.google.com/books?id=9ZZrW_j9XrcC&pg=PA469|archivedate=8 September 2017|df=dmy-all}}</ref><ref>{{웹 인용|title=Cysteine|url=http://www.umm.edu/health/medical/altmed/supplement/cysteine|website=University of Maryland Medical Center|accessdate=23 June 2017|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170701184417/http://www.umm.edu/health/medical/altmed/supplement/cysteine|archivedate=1 July 2017|df=dmy-all}}</ref>

일반적인 부작용으로는 구강으로 복용 시 메스꺼움, [[구토]]를 포함한다.<ref name=AHFS2015/> 피부가 간헐적으로 빨갛게 되거나 [[가려움]]이 발생할 수 있다.<ref name=AHFS2015/> 비면역형태의 [[과민증]]도 발생할 수 있다.<ref name=AHFS2015/> [[임신]] 중에 사용해도 안전한 것으로 간주된다.<ref name=AHFS2015/> 파라세타몰 과다복용의 경우 파라세타몰의 독성 분해 산물을 중화시킬 수 있는 [[산화방지제]]인 [[글루타티온]]의 수준을 증가시킴으로써 동작한다.<ref name=AHFS2015/> 흡입할 때에는 점액의 농도를 감소시키는 [[점액용해제]]의 역할을 한다.<ref>{{저널 인용|last=Sadowska|first=Anna M|last2=Verbraecken|first2=J|last3=Darquennes|first3=K|last4=De Backer|first4=WA|date=December 2006|title=Role of N-acetylcysteine in the management of COPD|journal=International Journal of Chronic Obstructive Pulmonary Disease|volume=1|issue=4|pages=425–434|issn=1176-9106|pmc=2707813|pmid=18044098|doi=10.2147/copd.2006.1.4.425}}</ref>

아세틸시스테인은 1960년에 처음 특허를 받았으며 1968년 사용이 허가되었다.<ref>{{서적 인용| last1 = Fischer | first1 = János | last2 = Ganellin | first2 = C. Robin | name-list-format = vanc | title = Analogue-Based Drug Discovery | date = 2006 | publisher = Wiley-VCH | location = Weinheim | isbn = 9783527607495 | page = 544 | url = https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA544 | url-status = live | archiveurl = https://web.archive.org/web/20170908143219/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA544 | archivedate = 8 September 2017 | df = dmy-all }}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=dmy-all}}</ref> [[제네릭 의약품]]으로 구매가 가능하며 저렴한 편이다.<ref>{{서적 인용| last1 = Baker | first1 = Emma | name-list-format = vanc | title = Top 100 drugs : clinical pharmacology and practical prescribing | date = 2014 | isbn = 9780702055157 | page = Acetylcysteine | url = https://books.google.com/books?id=oeYjAwAAQBAJ&pg=PT44 | url-status = live | archiveurl = https://web.archive.org/web/20170908143223/https://books.google.com/books?id=oeYjAwAAQBAJ&pg=PT44 | archivedate = 8 September 2017 | df = dmy-all }}</ref>

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Acetylcysteine U.S. National Library of Medicine: Drug Information Portal - Acetylcysteine]

{{항산화제}}

[[분류:산화 방지제]]
[[분류:해독제]]
[[분류:싸이올]]
[[분류:세계 보건 기구 필수 의약품]]
[[분류:부형제]]
[[분류:아세트아마이드]]
[[분류:아미노산 유도체]]
[[분류:흥분성 아미노산 수용체 리간드]]