{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| tradename = Rapamune
| synonyms = Rapamycin
| verifiedrevid = 732542693
| IUPAC_name = (1''R'',9''S'',12''S'',15''R'',16''E'',18''R'',19''R'',21''R'',23''S'',24''E'',26''E'',28''E'',<br />30''S'',32''S'',35''R'')-1,18-dihydroxy-12-{(2''R'')-1-[(1''S'',3''R'',<br />4''R'')-4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-<br />19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-<br />11,36-dioxa-4-azatricyclo[30.3.1.0~4,9~]hexatria<br />conta-16,24,26,28-tetraene-2,3,10,14,20-pentone
| image = Sirolimus structure.svg
| width = 250
| image2 = Sirolimus-from-1C9H-3D-sticks.png
| width2 = 250
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10482078
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = W36ZG6FT64
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 9168
| smiles = O[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]4CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)[C@@H](OC)C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N3CCCC[C@H]3C(=O)O4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QFJCIRLUMZQUOT-HPLJOQBZSA-N
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 53123-88-9
| ATC_prefix = L04
| ATC_suffix = AA10
| ATC_supplemental = {{ATC|S01|XA23}}
| ChEMBL = 413
| PDB_ligand = RAP
| PubChem = 5284616
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00877
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00753
| C=51 | H=79 | N=1 | O=13
| bioavailability = 14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals<ref>{{저널 인용|last1=Buck|first1=Marcia L. | name-list-style = vanc |title=Immunosuppression With Sirolimus After Solid Organ Transplantation in Children|journal=Pediatric Pharmacotherapy|date=2006|volume=12|issue=2|url=http://www.medscape.com/viewarticle/524753_4}}</ref>
| protein_bound = 92%
| metabolism = Hepatic
| elimination_half-life = 57–63 hours<ref name="Pubchem Rapamycin">{{웹 인용|title=Rapamycin|url=https://pubchem.ncbi.nlm.nih.gov/compound/5284616|website=PubChem Compound|publisher=National Center for Biotechnology Information|accessdate=1 August 2016}}</ref>
| licence_EU = yes
| licence_US = Sirolimus
| pregnancy_AU = C
| pregnancy_US = C
| legal_US = Rx-only
| routes_of_administration = Oral
| excretion = Mostly faecal
| solubility = 0.0026<ref>{{저널 인용| vauthors = Simamora P, Alvarez JM, Yalkowsky SH | title = Solubilization of rapamycin | journal = International Journal of Pharmaceutics | volume = 213 | issue = 1–2 | pages = 25–9 | date = February 2001 | pmid = 11165091 | doi = 10.1016/s0378-5173(00)00617-7 }}</ref>
}}
'''시롤리무스'''(Sirolimus) 또는 '''라파마이신'''(Rapamycin)은 기관이식시 사용되는 새로 개발된 면역억제제이다. 특히 [[콩팥|신장]] 이식에 유용하게 쓰인다. 시롤리무스는 [[이스터 섬]]의 토양에사는 세균 스트렙토마이세스 히그로스코피커스(Streptomyces Hygroscopicus)에서발견된 매크로라이드(Macrolide)이다.

== 각주 ==
{{각주}}

{{토막글|의학}}

[[분류:락탐]]
[[분류:면역 억제제]]
[[분류:항노화 물질]]
[[분류:폴리엔]]
[[분류:마크롤라이드]]
[[분류:화이자의 제품]]