{{위키데이터 속성 추적}}
'''심장독성'''(心臟毒性, cardiotoxicity) 또는 '''심독성'''(心毒性)은 [[심장]]의 전기생리적 기능 이상이나 [[심근병증|근육의 손상]]을 일으키는 독성이다.<ref>{{인용|last=Sishi |first=Balindiwe J. N. |title=Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity |date=2015-01-01 |url=https://www.sciencedirect.com/science/article/pii/B9780128010334000102 |work=Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging |pages=157–173 |editor-last=Hayat |editor-first=M. A. |place=Amsterdam |publisher=Academic Press |language=en |doi=10.1016/b978-0-12-801033-4.00010-2 |isbn=978-0-12-801033-4 |access-date=2022-07-06}}</ref> 심장독성으로 인해 심장의 기능이 약해져 혈액을 순환시키는 효율이 떨어지게 된다. 심장독성의 원인으로는 [[독소루비신]] 등의 [[안트라사이클린]] 계열 약제가 대표적인 일부 [[화학요법]] 약제들,<ref>{{저널 인용|pages=675–83 |doi=10.1161/CIRCULATIONAHA.109.902221 |title=Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first.   |year=2010 |last1=Huang |first1=C. |last2=Zhang |first2=X. |last3=Ramil |first3=J. M. |last4=Rikka |first4=S. |last5=Kim |first5=L. |last6=Lee |first6=Y. |last7=Gude |first7=N. A. |last8=Thistlethwaite |first8=P. A. |last9=Sussman |first9=M. A. |journal=Circulation |volume=121 |issue=5 |pmid=20100968 |pmc=2834271 }}</ref><ref name=Volkova>{{저널 인용| title = Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment| authors = Volkova M, Russell R| journal = Curr Cardiol Rev| year = 2011 | volume = 7| issue = 4| pages = 214–220| doi = 10.2174/157340311799960645 | pmid = 22758622| pmc = 3322439 }}</ref> [[방사선치료]]를 포함한 화학요법,<ref>{{저널 인용|last=Suchorska |first=Wiktoria M. |date=2020-01-01 |title=Radiobiological models in prediction of radiation cardiotoxicity |journal=Reports of Practical Oncology & Radiotherapy |language=en |volume=25 |issue=1 |pages=46–49 |doi=10.1016/j.rpor.2019.12.001 |issn=1507-1367 |pmc=6931197 |pmid=31889920}}</ref> [[신경성 식욕부진증]]의 [[합병증]], [[중금속]] 섭취,<ref>{{저널 인용|last=Nigra |first=Anne E |last2=Ruiz-Hernandez |first2=Adrian |last3=Redon |first3=Josep |last4=Navas-Acien |first4=Ana |last5=Tellez-Plaza |first5=Maria |year=2016 |title=Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801549/ |journal=Current environmental health reports |volume=3 |issue=4 |pages=416–433 |doi=10.1007/s40572-016-0117-9 |issn=2196-5412 |pmc=5801549 |pmid=27783356}}</ref> [[코카인]]과 같은 강력한 [[각성제]]의 장기간 남용이나 고용량 복용,<ref>{{저널 인용|last=Pergolizzi |first=Joseph V |last2=Magnusson |first2=Peter |last3=LeQuang |first3=Jo Ann K |last4=Breve |first4=Frank |last5=Varrassi |first5=Giustino |title=Cocaine and Cardiotoxicity: A Literature Review |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136464/ |journal=Cureus |volume=13 |issue=4 |pages=e14594 |doi=10.7759/cureus.14594 |issn=2168-8184 |pmc=8136464 |pmid=34036012}}</ref> [[부피바카인]]과 같은 약제를 잘못 처방한 경우 등이 있다.<ref>{{저널 인용| vauthors = de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A | title = [Cardiotoxicity of local anesthetics] | journal = Cahiers d'Anesthésiologie | volume = 41 | issue = 6 | pages = 589–598 | date = 1993 | pmid = 8287299 }}</ref>

== 같이 보기 ==
* [[바트라코톡신]]
* [[심부전]]
* [[약물 상호작용]]
== 각주 ==
{{각주}}

{{전거 통제}}
{{토막글|의학}}

[[분류:심장병]]
[[분류:독소]]