{{위키데이터 속성 추적}}
[[파일:Protein SH2B2 PDB 1q2h.png|섬네일|250픽셀|SH2B2 구조]]
'''SH2B 어댑터 단백질 2'''(SH2B Adapter Protein) 또는 '''SH2B2'''는 인간에서 [[유전자]]에 의해 암호화되는 [[단백질]]이다.<ref name="pmid9233773">{{저널 인용|제목=Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation|저널=Oncogene|날짜=Aug 1997|권=15|호=1|쪽=7–15|doi=10.1038/sj.onc.1201163|pmc=|pmid=9233773}}</ref><ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603|제목=Entrez Gene: SH2B2 SH2B adaptor protein 2|확인날짜=}}</ref>   

== 기능 ==
이 유전자에 의해 암호화된 단백질은 B 림프구로 발현되고 플렉스트린 상동성(Pleckstrin Homology) 및 src 상동성 2 도메인(SH2 Domain)을 포함한다. 버킷 림프종 세포주에서, 그것은 B 세포 수용체 자극에 반응하여 인산화 된 [[티로신]]이다. 자극 후 자극 및 Grb2와 독립적으로 Shc에 결합하기 때문에, 수용체로부터 Shc/Grb2로의 신호 전달에 역할을 하는 것으로 보인다.<ref name="entrez">{{웹 인용|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603|제목=Entrez Gene: SH2B2 SH2B adaptor protein 2|확인날짜=}}</ref>  

== 상호 작용 ==
SH2B2는 TrkA<ref name="pmid9856458">{{저널 인용|제목=Identification and characterization of novel substrates of Trk receptors in developing neurons|저널=Neuron|날짜=Nov 1998|권=21|호=5|쪽=1017–29|doi=10.1016/S0896-6273(00)80620-0|pmid=9856458}}</ref>  및 Cbl 유전자와 상호 작용 하는 것으로 나타났다.<ref name="pmid10374881">{{저널 인용|제목=APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl|저널=Leukemia|날짜=May 1999|권=13|호=5|쪽=760–7|doi=10.1038/sj/leu/2401397|pmid=10374881}}</ref><ref name="pmid18273061">{{저널 인용|제목=Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates|저널=EMBO J.|날짜=Mar 2008|권=27|호=5|쪽=804–16|doi=10.1038/emboj.2008.18|pmc=2265755|pmid=18273061}}</ref>   

== 각주 ==
{{각주}}

== 외부 링크 ==
{{참고 자료 시작|2}}
* {{저널 인용|제목=Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes|저널=Genome Res.|연도=1998|권=8|호=10|쪽=1060–73|doi=10.1101/gr.8.10.1060|pmc=310788|pmid=9799793}}
* {{저널 인용|제목=Identification and characterization of novel substrates of Trk receptors in developing neurons|저널=Neuron|연도=1999|권=21|호=5|쪽=1017–29|doi=10.1016/S0896-6273(00)80620-0|pmid=9856458}}
* {{저널 인용|제목=APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis|저널=Oncogene|연도=1999|권=18|호=3|쪽=759–67|doi=10.1038/sj.onc.1202326|pmid=9989826}}
* {{저널 인용|제목=Identification of the APS protein as a novel insulin receptor substrate|저널=J. Biol. Chem.|연도=1999|권=274|호=16|쪽=11186–93|doi=10.1074/jbc.274.16.11186|pmid=10196204}}
* {{저널 인용|제목=APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl|저널=Leukemia|연도=1999|권=13|호=5|쪽=760–7|doi=10.1038/sj/leu/2401397|pmid=10374881}}
* {{저널 인용|제목=Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins|저널=Biochem. Biophys. Res. Commun.|연도=2000|권=272|호=1|쪽=45–54|doi=10.1006/bbrc.2000.2736|pmid=10872802}}
* {{저널 인용|제목=SH2-B family members differentially regulate JAK family tyrosine kinases|저널=J. Biol. Chem.|연도=2002|권=277|호=10|쪽=8673–81|doi=10.1074/jbc.M109165200|pmid=11751854}}
* {{저널 인용|제목=APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes|저널=Mol. Cell. Biol.|연도=2002|권=22|호=11|쪽=3599–609|doi=10.1128/MCB.22.11.3599-3609.2002|pmc=133825|pmid=11997497}}
* {{저널 인용|제목=Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity|저널=Oncogene|연도=2002|권=21|호=50|쪽=7720–9|doi=10.1038/sj.onc.1205927|pmid=12400014}}
* {{저널 인용|제목=Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling|저널=J. Biol. Chem.|연도=2004|권=279|호=20|쪽=21526–32|doi=10.1074/jbc.M307740200|pmid=15031295}}
* {{저널 인용|제목=Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex|저널=J. Biol. Chem.|연도=2004|권=279|호=37|쪽=38881–8|doi=10.1074/jbc.M406101200|pmid=15231829}}
* {{저널 인용|제목=Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins|저널=J. Biol. Chem.|연도=2005|권=280|호=19|쪽=18943–9|doi=10.1074/jbc.M414157200|pmid=15737992}}
* {{저널 인용|제목=APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation|저널=Biochem. Biophys. Res. Commun.|연도=2005|권=330|호=3|쪽=1005–13|doi=10.1016/j.bbrc.2005.03.073|pmid=15809095}}
* {{저널 인용|제목=Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588|저널=J. Biol. Chem.|연도=2006|권=280|호=45|쪽=37827–32|doi=10.1074/jbc.M505959200|pmid=16141217}}
* {{저널 인용|제목=Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling|저널=Endocrinology|연도=2007|권=148|호=4|쪽=1615–21|doi=10.1210/en.2006-1010|pmc=4710543|pmid=17204555}}
{{참고 자료 끝}}

{{PDB Gallery|geneid=10603}}

[[분류:인간 7번 염색체상 유전자]]