{{위키데이터 속성 추적}}
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 477316402
| IUPAC_name = Methyl [5-(propylthio)-1''H''-benzoimidazol-2-yl]carbamate
| image = Albendazole.svg
| image2 = Albendazole-from-xtal-2007-3D-balls.png
| width2 = 250px

<!--Clinical data-->
| tradename = Albenza, Valbazen, Zentel, others
| Drugs.com = {{drugs.com|monograph|albendazole}}
| MedlinePlus = a610019
| pregnancy_AU = D
| pregnancy_US = C
| legal_AU = S4
| legal_CA = Rx-only
| legal_UK = POM
| legal_US = Rx-only
| legal_US_comment = (for humans; veterinary suspension and paste are both OTC)<ref name=plumb/>
| routes_of_administration = [[:en:Oral administration|By mouth]]

<!--Pharmacokinetic data-->
| bioavailability = <5%<ref name=MSR >{{웹 인용|title=Albenza, (albendazole) dosing, indications, interactions, adverse effects, and more|work=Medscape Reference|publisher=WebMD|accessdate=February 25, 2014|url=http://reference.medscape.com/drug/albenza-albendazole-342648#showall|url-status=live|archiveurl=https://web.archive.org/web/20140301073400/http://reference.medscape.com/drug/albenza-albendazole-342648#showall|archivedate=March 1, 2014|df=}}</ref>
| protein_bound = 70%<ref name = MSR/>
| metabolism = [[간]]<ref name = MSR/>
| elimination_half-life = 8-12 hours<ref name=MSR/>
| excretion = Bile (humans)<br />Urine (ruminants)

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 54965-21-8
| ATC_prefix = P02
| ATC_suffix = CA03
| ATC_supplemental =  {{ATCvet|P52|AC11}}
| PubChem = 2082
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00518
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 1998
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = F4216019LN
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00134
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 16664
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1483
| NIAID_ChemDB = 007895

<!--Chemical data-->
| C=12 | H=15 | N=3 | O=2 | S=1
| molecular_weight = 265.333 g/mol
| smiles = CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = HXHWSAZORRCQMX-UHFFFAOYSA-N
| melting_point = 208
| melting_high = 210
}}

'''알벤다졸'''({{lang|en|albendazole}}, albendazolum<ref name=plumb>{{서적 인용| last=Plumb | first=Donald C. | title=Plumb's Veterinary Drug Handbook | chapter=Albendazole | location=Stockholm, Wisconsin; Ames, Iowa | date=2011 | edition=7th | publisher=Wiley | isbn=978-0-470-95964-0 | pages=19–21}}</ref>)은 다양한 [[기생충]] 감염을 치료하기 위해 사용되는 약물이다.<ref name=AHFS2015/> [[편모충증]], [[편충증]], [[필라리아병]], [[신경낭미충증]], [[포충증]], [[요충증]], [[회충증]] 등에 유용하다.<ref name=AHFS2015/> 구강으로 복용한다.<ref name=AHFS2015>{{웹 인용|title=Albendazole |url=https://www.drugs.com/monograph/albendazole.html |publisher=The American Society of Health-System Pharmacists |accessdate=August 18, 2015 |website=Drugs.com |url-status=live |archiveurl=https://web.archive.org/web/20150923232451/http://www.drugs.com/monograph/albendazole.html |archivedate=September 23, 2015 |df= }}</ref>

일반적인 부작용으로는 메스꺼움, 복통, 두통이 포함된다.<ref name=AHFS2015/> 잠재적으로 심각한 부작용으로는 [[골수 억제]]가 포함되며 보통 약물을 중단할 때 개선된다.<ref name=AHFS2015/> 간의 염증이 보고되었으며 간 질환 이력이 있는 사람에게는 더 큰 위험이 닥칠 수 있다.<ref name=AHFS2015/> 미국에서는 [[임부 투여 안전성|임신 분류]] C, 오스트레일리아에서는 분류 D이며 이는 임신한 여성이 섭취할 경우 피해가 있음을 의미한다.<ref name=AHFS2015/><ref>{{웹 인용|title=Prescribing medicines in pregnancy database |url=http://www.tga.gov.au/hp/medicines-pregnancy.htm#.U1Yw8Bc3tqw |author=Australian Government |accessdate=April 22, 2014 |date=March 3, 2014 |url-status=live |archiveurl=https://web.archive.org/web/20140408040902/http://www.tga.gov.au/hp/medicines-pregnancy.htm#.U1Yw8Bc3tqw |archivedate=April 8, 2014 |df= }}</ref> 알벤다졸은 폭넓은 효능을 지닌 [[벤조이미다졸]]형 [[항기생충 작용제]]이다.<ref name=AHFS2015/>

알벤다졸은 1975년 개발되었다.<ref>{{서적 인용|title=Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life |date=2014 |publisher=John Wiley & Sons |isbn=9781118819593 |page=64 |url=https://books.google.com/books?id=VOLhBQAAQBAJ&pg=PA64 |url-status=live |archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=VOLhBQAAQBAJ&pg=PA64 |archivedate=2017-09-08 |df= }}</ref> [[의료제도]]에 필수적인 가장 효과적이고 안전한 의약품 목록인 [[WHO 필수 의약품 목록]]에 등재되어 있다.<ref name=WHO19th>{{웹 인용|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=December 8, 2016|date=April 2015|url-status=live|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=December 13, 2016|df=}}</ref> [[개발도상국]]의 도매가는 한 도스 당 0.01 ~ 0.06 USD 사이이다.<ref name=GlobPrice>{{웹 인용|title=Albendazole|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=12&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=August 18, 2015|archiveurl=https://web.archive.org/web/20170305002135/http://mshpriceguide.org/en/single-drug-information/?DMFId=12&searchYear=2014|archivedate=March 5, 2017|url-status=dead|df=}}</ref> 그러나 미국에서는 매우 비싼 편인데, 2015년 기준으로 비용은 도스 당 약 201 USD에 달한다.<ref>{{저널 인용|last1=Alpern|first1=JD|last2=Song|first2=J|last3=Stauffer|first3=WM|title=Essential Medicines in the United States—Why Access Is Diminishing|journal=The New England Journal of Medicine|date=May 19, 2016|volume=374|issue=20|pages=1904–7|pmid=27192669|doi=10.1056/NEJMp1601559|url=http://www.gaffi.org/wp-content/uploads/Alpern-Essential-medicines-in-USA-and-price-New-Engl-J-Med-2016.pdf|access-date=2019-03-02|archive-date=2017-08-08|archive-url=https://web.archive.org/web/20170808153051/http://www.gaffi.org/wp-content/uploads/Alpern-Essential-medicines-in-USA-and-price-New-Engl-J-Med-2016.pdf|url-status=}}</ref>

== 의학적 이용 ==
알벤다졸은 다음의 치료에 효 과적이다:
* [[편형동물]]
** [[간질증]]<ref name=AHFS2015 />
** [[조충류]]<ref name=tripathi>{{서적 인용| last=Tripathi | first=K. D. | title=Essentials of Medical Pharmacology | date=September 30, 2013 | page=850 | url=https://books.google.com/books?id=FfG8AQAAQBAJ&pg=PA850 | publisher=JP Medical Ltd | isbn=978-93-5025-937-5 | url-status=live | archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=FfG8AQAAQBAJ&pg=PA850 | archivedate=September 8, 2017 | df= }}</ref>
*** [[낭충증]]<ref name="who_mpi_1">{{웹 인용|url=http://apps.who.int/medicinedocs/en/d/Jh2922e/3.1.1.html|title=Helminths: Cestode (tapeworm) infection: Albendazole|date=1995|website=WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition|publisher=[[세계보건기구]]|access-date=August 29, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150831034730/http://apps.who.int/medicinedocs/en/d/Jh2922e/3.1.1.html|archivedate=August 31, 2015|df=}}</ref>
*** 간, 허파, 복막의 [[포충증|포충병]](echinococcosis)<ref name="who_mpi_1"/><ref name="pmid12667231">{{저널 인용| author = Horton J | title = Albendazole for the Treatment of Echinococcosis | journal = Fundamental and Clinical Pharmacology | year = 2003 | volume = 17 | issue = 2 | pages = 205–212 | pmid = 12667231 | doi = 10.1046/j.1472-8206.2003.00171.x }}</ref>
* [[선형동물]]
** [[회충증]]<ref name="who_mpi_2">{{웹 인용|url=http://apps.who.int/medicinedocs/en/d/Jh2922e/3.2.1.html|title=Helminths: Intestinal nematode infection: Albendazole|date=1995|website=WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition|publisher=[[세계보건기구]]|access-date=August 29, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150831034212/http://apps.who.int/medicinedocs/en/d/Jh2922e/3.2.1.html|archivedate=August 31, 2015|df=}}</ref><ref name=sweet-gibbs>{{서적 인용| last1=Sweet | first1=Richard L. | last2=Gibbs | first2=Ronald S. | title=Infectious Diseases of the Female Genital Tract | date=2009 | pages=379, 382–383 | url=https://books.google.com/books?id=wuR_ngItU5oC&pg=PA379 | publisher=Lippincott Williams & Wilkins | isbn=978-0-7817-7815-2 | url-status=live | archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=wuR_ngItU5oC&pg=PA379 | archivedate=2017-09-08 | df= }}</ref>
** 아프리카너구리회충증<ref name=AHFS2015 />
** [[요충증]]<ref name="who_mpi_2"/>
** [[필라리아병]]<ref name=AHFS2015 /><ref name=yaffe-aranda>{{서적 인용| last1=Yaffe | first1=Sumner J. | last2=Aranda | first2=Jacob V. | title=Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice | date=2010 | pages=470–472 | url=https://books.google.com/books?id=1e2-yggGeUIC&pg=PA470 | publisher=Lippincott Williams & Wilkins | isbn=978-0-7817-9538-8 | url-status=live | archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=1e2-yggGeUIC&pg=PA470 | archivedate=2017-09-08 | df= }}</ref>
** [[악구충증]]<ref name=AHFS2015 /> 알벤다졸은 이버멕틴과 비슷한 효과를 내지만 이버멕틴의 경우 이틀, 알벤다졸은 21일이 필요하다.<ref name=turner-horton>{{서적 인용| last1=Turner | first1=Arthur | last2=Horton | first2=John | title=Logan Turner's Diseases of the Nose, Throat and Ear | chapter=Albendazole | date=December 30, 1987 | edition=10th | publisher=CRC Press | isbn=978-0-340-92767-0 | pages=2227–2239 | chapter-url=https://books.google.com/books?id=2-nwinRKtBQC&pg=PA2227}}</ref>
** [[식도충증]]<ref name=AHFS2015 />
** [[십이지장충]],<ref name="who_mpi_2"/>
** [[장모세선충증]]<ref name="who_mpi_2"/>
** [[만소넬라증]]<ref name=turner-horton />
** [[외소파고스토뭄속|외소파고스토뭄]]<ref name=AHFS2015 />
** [[간충증]]<ref name="who_mpi_2" /> (이버멕틴 또는 티아벤다졸의 대안)<ref name=AHFS2015 /><ref name=gouma>{{서적 인용| last=Gouma | first=D. J. | title=Update Gastroenterology 2004: New Developments in the Management of Benign Gastrointestinal Disorders | date=2004 | pages=144–145 | url=https://books.google.com/books?id=FfyJeSjyo-IC&pg=PA144 | publisher=John Libbey Eurotext | isbn=978-2-7420-0538-3 | url-status=live | archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=FfyJeSjyo-IC&pg=PA144 | archivedate=2017-09-08 | df= }}</ref>
** [[톡소카라증]]<ref name=AHFS2015 />
** [[선모충병]]<ref name=tripathi /> 또는 ''T. pseudospiralis''.
** [[모양선충]]<ref name=AHFS2015 /><ref name="who_mpi_2"/> 치료 시 1도스만으로 충분하다.<ref name=yaffe-aranda />
** [[편충증]]<ref name="who_mpi_2"/>([[메벤다졸]]의 대안)<ref name=AHFS2015 /><ref name=tripathi /> 1도스(dose)의 알벤다졸만 필요하다.<ref name=sweet-gibbs /> 이버멕틴과 함께 투여할 수도 있다.<ref name=finch>{{서적 인용| last1=Finch | first1=Roger G. | last2=Greenwood | first2=David | last3=Whitley | first3=Richard J. | last4=Norrby | first4=S. Ragnar | title=Antibiotic and Chemotherapy E-Book | date=November 30, 2010 | page=101 | url=https://books.google.com/books?id=DE4Mxc3aesEC&pg=PA101 | publisher=Elsevier Health Sciences | isbn=978-0-7020-4765-7}}</ref>
* [[편모충증]]<ref name=AHFS2015 /><ref name=who-hiv>{{웹 인용|url=http://apps.who.int/medicinedocs/en/d/Js2215e/9.2.html|title=Drugs: Albendazole|date=1999|website=WHO Model Prescribing Information: Drugs Used in HIV-Related Infections|publisher=[[세계보건기구]]|access-date=August 29, 2015|url-status=live|archiveurl=https://web.archive.org/web/20150829220338/http://apps.who.int/medicinedocs/en/d/Js2215e/9.2.html|archivedate=August 29, 2015|df=}}</ref>
* [[미포자충증]]<ref name=AHFS2015 /><ref name=who-hiv />
* [[육아종 아메바성 뇌염]]<ref name=wu>{{서적 인용| last=Wu | first=Jashin J. | title=Comprehensive Dermatologic Drug Therapy E-Book | date=October 18, 2012 | page=137 | url=https://books.google.com/books?id=Tqpsm5WKKlcC&pg=PA137 | publisher=Elsevier Health Sciences | isbn=978-1-4557-3801-4 | url-status=live | archiveurl=https://web.archive.org/web/20170908140627/https://books.google.com/books?id=Tqpsm5WKKlcC&pg=PA137 | archivedate=September 8, 2017 | df= }}</ref>
* [[절지동물]]
** [[옴 (질병)|옴]]<ref name=wu />
** [[머릿니]]<ref name=wu />
** [[승저증]]<ref>{{저널 인용 | last1=Francesconi | first1=Fabio | last2=Lupi | first2=Omar | title=Myiasis | journal=Clinical Microbiology Reviews | date=January 1, 2012 | url=http://cmr.asm.org/content/25/1/79 | pmid=22232372 | doi=10.1128/CMR.00010-11 | issn=0893-8512 | volume=25 | issue=1 | pages=79–105 | pmc=3255963 | access-date=2019-03-02 | archive-date=2019-08-21 | archive-url=https://web.archive.org/web/20190821024544/https://cmr.asm.org/content/25/1/79 | url-status= }}</ref>

== 같이 보기 ==
* [[메벤다졸]]

== 각주 ==
{{각주}}

== 외부 링크 ==
* [http://www.cartercenter.org/health/lf/index.html The Carter Center Lymphatic Filariasis Elimination Program]
* [http://www.medicinenet.com/albendazole-oral/article.htm MedicineNet article]
* [http://www.rxlist.com/albenza-drug.htm Albenza description at RxList]

[[분류:구충제]]
[[분류:벤즈이미다졸]]
[[분류:카밤산염]]
[[분류:싸이오에터]]
[[분류:세계 보건 기구 필수 의약품]]