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human histidine decarboxylase
23411280_task2
Sentence: Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O" ]
Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase.
[ "Inhibitory", "activity", "of", "Filipendula", "ulmaria", "constituents", "on", "recombinant", "human", "histidine", "decarboxylase", "." ]
[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Epidermal growth factor receptor is a GENE-Y, Ras is a GENE-N
14633707_task0
Sentence: Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O" ]
Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
[ "Epidermal", "growth", "factor", "receptor", "autocrine", "signaling", "in", "RIE-1", "cells", "transformed", "by", "the", "Ras", "oncogene", "enhances", "radiation", "resistance", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Epidermal growth factor receptor is a GENE-Y, Ras is a GENE-N
14633707_task1
Sentence: Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Instructions: please typing these entity words according to sentence: Epidermal growth factor receptor, Ras Options: GENE-Y, GENE-N
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O" ]
Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
[ "Epidermal", "growth", "factor", "receptor", "autocrine", "signaling", "in", "RIE-1", "cells", "transformed", "by", "the", "Ras", "oncogene", "enhances", "radiation", "resistance", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Epidermal growth factor receptor, Ras
14633707_task2
Sentence: Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Instructions: please extract entity words from the input sentence
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O" ]
Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
[ "Epidermal", "growth", "factor", "receptor", "autocrine", "signaling", "in", "RIE-1", "cells", "transformed", "by", "the", "Ras", "oncogene", "enhances", "radiation", "resistance", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
aspirinas is a NORMALIZABLES, omeprazol is a NORMALIZABLES, diclofenaco is a NORMALIZABLES, aspirinas is a NORMALIZABLES, Hb is a PROTEINAS, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES
409_task0
Sentence: Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal.
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[ "NORMALIZABLES", "PROTEINAS" ]
aspirinas is a NORMALIZABLES, omeprazol is a NORMALIZABLES, diclofenaco is a NORMALIZABLES, aspirinas is a NORMALIZABLES, Hb is a PROTEINAS, urea is a NORMALIZABLES, creatinina is a NORMALIZABLES
409_task1
Sentence: Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal. Instructions: please typing these entity words according to sentence: aspirinas, omeprazol, diclofenaco, aspirinas, Hb, urea, creatinina Options: NORMALIZABLES, PROTEINAS
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Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal.
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[ "NORMALIZABLES", "PROTEINAS" ]
aspirinas, omeprazol, diclofenaco, aspirinas, Hb, urea, creatinina
409_task2
Sentence: Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal. Instructions: please extract entity words from the input sentence
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Hombre de 77 años derivado al servicio de Urgencias hospitalario desde su centro de salud para valoración de hematemesis. Como antecedentes personales el paciente refería sangrado digestivo alto dos años antes, en contexto de toma de aspirinas por proceso catarral, así como crisis renoureterales (CRU) de repetición y asma. No se disponía en ese momento de más información relativa a sus antecedentes personales. Se encontraba tomando tratamiento inhalatorio antiinflamatorio-broncodilatador; por voluntad propia el paciente había suspendido recientemente el tratamiento habitual con omeprazol. Diagnosticado tres días antes de CRU en su centro de salud por dolor lumbar bajo de perfil cólico irradiado a cuadrante inferior izquierdo (CII), había recibido diclofenaco intramuscular y aspirinas a demanda, con alivio parcial. Ante la presentación de hematemesis, se deriva para valoración. En el servicio de Urgencias el paciente refiere, además de dicho dolor lumbar irradiado, que reconoce como de características similares a CRU previas, la presentación en las últimas ocho horas de ardor de estómago, así como temblor al levantarse de la cama e inestabilidad, que ha condicionado caída y traumatismo nasal. Asimismo, había presentado en este período tres vómitos de contenido sanguinolento. En la exploración física destacaban buen estado general, TA de 70/50 mm de Hg con relleno capilar normal, FC de 90 lpm, ta de 36º C; nauseoso, con palidez concomitante a las náuseas, pero basalmente normocoloreado; herida en puente nasal con restos de sangrado en fosas nasales y restos en “posos de café” en comisuras labiales; abdomen doloroso a la palpación profunda en CII, sin signos de irritación peritoneal ni aparentes masas y tacto rectal negativo para sangre y melenas. Se extrajeron muestras para analítica y pruebas cruzadas y se inició sueroterapia por dos vías venosas periféricas, que consiguieron remontar las cifras tensionales sin normalizarlas. En la analítica, Hb, 12,9 g/dL, Hto. 36,1%, leucocitos 27.500/µL con 87% de neutrófilos, plaquetas y coagulación normales; urea 52 mg/dL, creatinina 2,86 g/dL; resto normal. Ante esta situación de inestabilidad hemodinámica y hematemesis en paciente con antecedentes de hemorragia digestiva alta y tratamiento actual con fármacos potencialmente gastrolesivos, se solicitó endoscopia urgente. La endoscopia inmediata objetivó esófago con mucosa de aspecto claramente isquémico desde los 30 cm y necrótico hasta los 38 cm, así como fundus, cuerpo gástrico, incisura y antro normales, con algún resto hemático mínimo. Durante la realización de la endoscopia el paciente entró en parada cardiorrespiratoria por actividad eléctrica sin pulso. Las maniobras de resucitación resultaron infructuosas y el paciente falleció. La necropsia reveló esofagitis aguda necrotizante erosiva en los 14 cm distales y arteriosclerosis aórtica, predominantemente abdominal y en bifurcación de ilíacas, con aneurisma sacular en aorta abdominal de 13 cm de longitud y 8 cm de diámetro roto, hemorragia retroperitoneal masiva de 3.000 cc, aproximadamente, y extensión a cavidad peritoneal.
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[ "NORMALIZABLES", "PROTEINAS" ]
Zeit is an umlsterm, Patienten is an umlsterm, Endophthalmitis is an umlsterm, Patienten is an umlsterm, Antibiotika is an umlsterm, Patientengruppe is an umlsterm, Endophthalmitis is an umlsterm, Arbeit is an umlsterm, Behandlung is an umlsterm
DerOpthalmologe.70940552.ger.abstr_task0
Sentence: In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden .
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[ "umlsterm" ]
Zeit is an umlsterm, Patienten is an umlsterm, Endophthalmitis is an umlsterm, Patienten is an umlsterm, Antibiotika is an umlsterm, Patientengruppe is an umlsterm, Endophthalmitis is an umlsterm, Arbeit is an umlsterm, Behandlung is an umlsterm
DerOpthalmologe.70940552.ger.abstr_task1
Sentence: In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden . Instructions: please typing these entity words according to sentence: Zeit, Patienten, Endophthalmitis, Patienten, Antibiotika, Patientengruppe, Endophthalmitis, Arbeit, Behandlung Options: umlsterm
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In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden .
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[ "umlsterm" ]
Zeit, Patienten, Endophthalmitis, Patienten, Antibiotika, Patientengruppe, Endophthalmitis, Arbeit, Behandlung
DerOpthalmologe.70940552.ger.abstr_task2
Sentence: In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden . Instructions: please extract entity words from the input sentence
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In der Zeit von Januar 1994 bis Juni 1996 wurden an der Universitaets-Augenklinik Leipzig 18 Patienten aufgrund einer Endophthalmitis vitrektomiert . Alle Patienten erhielten intravitreale und systemische Antibiotika in Uebereinstimmung mit der ersten Patientengruppe der Endophthalmitis vitrectomy study " . " Bei dieser retrospektiven Arbeit sollten die funktionellen Ergebnisse der operativen Behandlung untersucht werden .
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[ "umlsterm" ]
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HNO.70450378.eng.abstr_task0
Sentence: Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed .
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[ "umlsterm" ]
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HNO.70450378.eng.abstr_task1
Sentence: Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed . Instructions: please typing these entity words according to sentence: outer hair cells, efferent nerves, acoustic stimulation, frequency, ears, adults, hearing, women, men, age, Sound, frequencies, frequency, frequency, frequencies, frequency, specificity, frequencies, frequencies, frequencies, amplifier, sound Options: umlsterm
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Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed .
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[ "umlsterm" ]
outer hair cells, efferent nerves, acoustic stimulation, frequency, ears, adults, hearing, women, men, age, Sound, frequencies, frequency, frequency, frequencies, frequency, specificity, frequencies, frequencies, frequencies, amplifier, sound
HNO.70450378.eng.abstr_task2
Sentence: Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed . Instructions: please extract entity words from the input sentence
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Distortion product otoacoustic emissions ( DPOAEs ) are probably based on the motile properties of the cochlear outer hair cells ( OHCs ) , which are richly innervated by medial olivo-cochlear efferent nerves ( MOCs ) . DPOAEs provide a stimulating model for functional exploration of the efferent system . The influences of contralateral acoustic stimulation were studied on the amplitude of ipsilateral DPOAEs at the frequency 2f1-f2. Fifteen ears of adults with normal hearing ( 7 women , 8 men , mean age ; 23.1 +/- 4.2 years ) were examined . Sound stimulation consisted of exposure to 6 successive series of contralateral pure tones at frequencies between 0.5 and 4.0 kHz and low intensities of 30 dB HL . DP grams were registered with f2 ranging from 708 to 6165 Hz. Contralateral pure tones in the frequency range above 750 Hz and with intensities of 30 dB HL increased the ipsilaterally registered DPOAE amplitudes . The results showed that this increase was frequency specific , at least for frequencies at 1 and 2 kHz . The frequency specificity was especially marked when ipsilateral f2 was near 1 kHz . Contralateral frequencies of 3 and 4 kHz induced a significant , increasing effect , including ipsilateral frequencies around f2=3 kHz ( or 4 kHz ) and also lower frequencies around f2=1 kHz . Our results support the concept that the observed increase in DPOAE amplitudes is mediated by the medial olivo-cochlear efferent system . The rule of OHCs as a cochlear amplifier in the presence of contralateral low-intensity sound stimulation is discussed .
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[ "umlsterm" ]
Children is a Person, aged is a Person, 0 - 59 months is a Value, living with families registered in the rural Bandim Health Project Health is a Observation, Demographic Surveillance Site is a Visit
NCT03460002_inc_task0
Sentence: Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Person, Observation, Visit, Value
[ "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Visit", "I-Visit", "I-Visit", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent.
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[ "Observation", "Visit", "Value", "Person" ]
Children is a Person, aged is a Person, 0 - 59 months is a Value, living with families registered in the rural Bandim Health Project Health is a Observation, Demographic Surveillance Site is a Visit
NCT03460002_inc_task1
Sentence: Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent. Instructions: please typing these entity words according to sentence: Children, aged, 0 - 59 months, living with families registered in the rural Bandim Health Project Health, Demographic Surveillance Site Options: Person, Observation, Visit, Value
[ "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Visit", "I-Visit", "I-Visit", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent.
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[ "Observation", "Visit", "Value", "Person" ]
Children, aged, 0 - 59 months, living with families registered in the rural Bandim Health Project Health, Demographic Surveillance Site
NCT03460002_inc_task2
Sentence: Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent. Instructions: please extract entity words from the input sentence
[ "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Visit", "I-Visit", "I-Visit", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Children aged 0-59 months living with families registered in the rural Bandim Health Project Health and Demographic Surveillance Site are included, provided a parent/guardian consent.
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[ "Observation", "Visit", "Value", "Person" ]
Augen is an umlsterm, Augen is an umlsterm, Elektrodenpositionen is an umlsterm, Auge is an umlsterm, Bindehautsack is an umlsterm, Fourier - Analyse is an umlsterm
DerOpthalmologe.70940217.ger.abstr_task0
Sentence: Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP .
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[ "umlsterm" ]
Augen is an umlsterm, Augen is an umlsterm, Elektrodenpositionen is an umlsterm, Auge is an umlsterm, Bindehautsack is an umlsterm, Fourier - Analyse is an umlsterm
DerOpthalmologe.70940217.ger.abstr_task1
Sentence: Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP . Instructions: please typing these entity words according to sentence: Augen, Augen, Elektrodenpositionen, Auge, Bindehautsack, Fourier - Analyse Options: umlsterm
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Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP .
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[ "umlsterm" ]
Augen, Augen, Elektrodenpositionen, Auge, Bindehautsack, Fourier - Analyse
DerOpthalmologe.70940217.ger.abstr_task2
Sentence: Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP . Instructions: please extract entity words from the input sentence
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Als Indikator fuer die Ganglienzellfunktion wird inzwischen das Muster-ERG ( MERG ) eingesetzt . Bisher gibt es noch wenige Untersuchungen zur Reproduzierbarkeit , und diese widersprechen sich . Wir untersuchten die Reproduzierbarkeit unter Bedingungen entsprechend den ISCEV-Empfehlungen zum MERG . Bei 42 Augen wurden mit DTL-Elektroden simultan das MERG und das VEP auf Schachbrettreize sowohl transient ( 2 Wechsel/s ) als auch Steady-state ( 16 Wechsel/s ) abgeleitet . Die Karogroessen betrugen 0,4 0,8 und 16 Grad , ; die Leuchtdichte 45 cd/m2, der Kontrast 98% und die Feldgroesse 32 Gradx27 Grad . Die Messungen wurden genau 1 Woche spaeter zur gleichen Stunde wiederholt . Zusaetzlich verglichen wir bei 16 Augen 2 verschiedene Elektrodenpositionen am Auge ( 1. auf der Hornhaut laengs der Unterlidkante , 2. tief im unteren Bindehautsack ) und fanden 20% groessere Amplituden bei der Position 1. Als Mass fuer die Reproduzierbarkeit berechneten wir den Variationskoeffizienten der Amplitude bei Messwiederholung . Ueber die Karogroessen gemittelt betrug er 7 +/- 1% beim Steady-state-MERG , 9 +/- 1% beim transienten MERG und 12 +/- 2% beim Steady-state' , bzw. 14 +/- 3% beim transienten VEP . Fuer die Latenz des Muster-ERGs bei Messwiederholung betrug der Variationskoeffizient 1,5% . Unter Steady-state-Bedingungen ist die Amplitudenreproduzierbarkeit etwas hoeher als transient ; dies fuehren wir auf die Fourier-Analyse zurueck , die weniger von Rauschueberlagerungen beeinflusst wird . Insgesamt liegt die Amplitudenreproduzierbarkeit des MERG etwas ueber der des VEP .
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[ "umlsterm" ]
ethanolamine oleate is a CHEMICAL, ethanolamine oleate is a CHEMICAL, EO is a CHEMICAL, fibrinopeptide A is a GENE-Y, FPA is a GENE-Y, fibrinopeptide B beta 15 - 42 is a GENE-Y, B beta 15 - 42 is a GENE-Y, FPA is a GENE-Y, B beta 15 - 42 is a GENE-Y, EO is a CHEMICAL, fibrin is a GENE-N, Ca2 + is a CHEMICAL, ethanolamine is a CHEMICAL, oleate is a CHEMICAL, benzyl alcohol is a CHEMICAL, FPA is a GENE-Y, EO is a CHEMICAL, oleate is a CHEMICAL, 125I is a CHEMICAL, fibrin(ogen ) is a GENE-N, EO is a CHEMICAL, oleate is a CHEMICAL, fibrinogen is a GENE-N
15225_task0
Sentence: Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL
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Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]
ethanolamine oleate is a CHEMICAL, ethanolamine oleate is a CHEMICAL, EO is a CHEMICAL, fibrinopeptide A is a GENE-Y, FPA is a GENE-Y, fibrinopeptide B beta 15 - 42 is a GENE-Y, B beta 15 - 42 is a GENE-Y, FPA is a GENE-Y, B beta 15 - 42 is a GENE-Y, EO is a CHEMICAL, fibrin is a GENE-N, Ca2 + is a CHEMICAL, ethanolamine is a CHEMICAL, oleate is a CHEMICAL, benzyl alcohol is a CHEMICAL, FPA is a GENE-Y, EO is a CHEMICAL, oleate is a CHEMICAL, 125I is a CHEMICAL, fibrin(ogen ) is a GENE-N, EO is a CHEMICAL, oleate is a CHEMICAL, fibrinogen is a GENE-N
15225_task1
Sentence: Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period. Instructions: please typing these entity words according to sentence: ethanolamine oleate, ethanolamine oleate, EO, fibrinopeptide A, FPA, fibrinopeptide B beta 15 - 42, B beta 15 - 42, FPA, B beta 15 - 42, EO, fibrin, Ca2 +, ethanolamine, oleate, benzyl alcohol, FPA, EO, oleate, 125I, fibrin(ogen ), EO, oleate, fibrinogen Options: GENE-N, GENE-Y, CHEMICAL
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Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]
ethanolamine oleate, ethanolamine oleate, EO, fibrinopeptide A, FPA, fibrinopeptide B beta 15 - 42, B beta 15 - 42, FPA, B beta 15 - 42, EO, fibrin, Ca2 +, ethanolamine, oleate, benzyl alcohol, FPA, EO, oleate, 125I, fibrin(ogen ), EO, oleate, fibrinogen
15225_task2
Sentence: Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period. Instructions: please extract entity words from the input sentence
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Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Changes in coagulation and fibrinolysis were investigated in 20 patients with oesophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5 per cent ethanolamine oleate (EO), by means of serial determination of plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (B beta 15-42). One hour after the completion of EIS, the value of FPA was significantly increased to 38.1 +/- 11.1 ng/ml (mean +/- s.e.m.) from a pre-EIS value of 7.1 +/- 1.4 ng/ml (P less than 0.01) and it gradually returned to normal range by 48 h after EIS. A very similar change was observed in the value of B beta 15-42 (P less than 0.01). These observations indicated that EIS provokes transient activation of coagulation and fibrinolysis. In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro. Nevertheless, an external application of EO or oleate over decapsulized kidney of rat resulted in a significant accumulation of 125I-labelled fibrin(ogen). From these results it was suggested that intravascular injection of EO, which exerts an inhibitory effect on coagulation in vitro, activates the local coagulation system. The activation may be accelerated by an acute inflammatory process provoked by oleate, which is supported by such clinical manifestations as mild fever, retrosternal pain leukocytosis and an increase in plasma fibrinogen level which was observed in all during the period.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Observer variation is a Outcome_Other, assessment of outcome is a Outcome_Other, outcome assessment is a Outcome_Other, dexanabinol is a Intervention_Pharmacological, head injury is a Participant_Condition, Eight hundred sixty - one patients is a Participant_Sample-size, severe traumatic brain injury is a Participant_Condition, placebo - controlled is a Intervention_Control, extended Glasgow Outcome Scale ; is a Outcome_Physical, outcome ratings is a Outcome_Other, Substantial observer variation is a Outcome_Other, discrepancies is a Outcome_Other, Consistency is a Outcome_Other
31731_task0
Sentence: Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers .
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[ "Outcome_Physical", "Participant_Sample-size", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Intervention_Pharmacological" ]
Observer variation is a Outcome_Other, assessment of outcome is a Outcome_Other, outcome assessment is a Outcome_Other, dexanabinol is a Intervention_Pharmacological, head injury is a Participant_Condition, Eight hundred sixty - one patients is a Participant_Sample-size, severe traumatic brain injury is a Participant_Condition, placebo - controlled is a Intervention_Control, extended Glasgow Outcome Scale ; is a Outcome_Physical, outcome ratings is a Outcome_Other, Substantial observer variation is a Outcome_Other, discrepancies is a Outcome_Other, Consistency is a Outcome_Other
31731_task1
Sentence: Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers . Instructions: please typing these entity words according to sentence: Observer variation, assessment of outcome, outcome assessment, dexanabinol, head injury, Eight hundred sixty - one patients, severe traumatic brain injury, placebo - controlled, extended Glasgow Outcome Scale ;, outcome ratings, Substantial observer variation, discrepancies, Consistency Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers .
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[ "Outcome_Physical", "Participant_Sample-size", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Intervention_Pharmacological" ]
Observer variation, assessment of outcome, outcome assessment, dexanabinol, head injury, Eight hundred sixty - one patients, severe traumatic brain injury, placebo - controlled, extended Glasgow Outcome Scale ;, outcome ratings, Substantial observer variation, discrepancies, Consistency
31731_task2
Sentence: Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers . Instructions: please extract entity words from the input sentence
[ "B-Outcome_Other", "I-Outcome_Other", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Observer variation in the assessment of outcome in traumatic brain injury : experience from a multicenter , international randomized clinical trial . OBJECTIVE Accurate and consistent outcome assessment is essential to randomized clinical trials . We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation . METHODS Eight hundred sixty-one patients with severe traumatic brain injury who were admitted to 86 centers were included in a multicenter , placebo-controlled , Phase III trial . Outcome was assessed at 3 and 6 months postinjury using the extended Glasgow Outcome Scale ; standardized assessment was facilitated by the use of a structured interview . Before initiation of trial centers , outcome ratings were obtained for sample cases to establish initial levels of agreement . Training sessions in outcome assessment were held , and problems in assigning outcome were investigated . During the trial , a process of central review was established to monitor performance . Interobserver variation was analyzed using the kappa statistic . RESULTS Substantial observer variation was found in the rating of sample cases ( weighted kappa , 0.72 ; confidence interval , 0.68-0.75 ) and in assigning outcome based on completed structured interviews ( weighted kappa , 0.61 ; confidence interval , 0.57-0.64 ) . In the early stages of the trial , a relatively large number of discrepancies ( 29-37 % ) were identified on central review . This number declined as the trial progressed and coincided with investigator training and feedback from central review . Centers with higher enrollment rates showed better performance . CONCLUSION Observer variation in outcome assessment is a significant problem for head injury trials . Consistency can be improved by standardizing procedures , training assessors , and monitoring the quality of assessments and providing feedback to interviewers .
[ "Observer", "variation", "in", "the", "assessment", "of", "outcome", "in", "traumatic", "brain", "injury", ":", "experience", "from", "a", "multicenter", ",", "international", "randomized", "clinical", "trial", ".", "OBJECTIVE", "Accurate", "and", "consistent", "outcome", "assessment", "is", "essential", "to", "randomized", "clinical", "trials", ".", "We", "aimed", "to", "explore", "observer", "variation", "in", "the", "assessment", "of", "outcome", "in", "a", "recently", "completed", "trial", "of", "dexanabinol", "in", "head", "injury", "and", "to", "consider", "steps", "to", "reduce", "such", "variation", ".", "METHODS", "Eight", "hundred", "sixty", "-", "one", "patients", "with", "severe", "traumatic", "brain", "injury", "who", "were", "admitted", "to", "86", "centers", "were", "included", "in", "a", "multicenter", ",", "placebo", "-", "controlled", ",", "Phase", "III", "trial", ".", "Outcome", "was", "assessed", "at", "3", "and", "6", "months", "postinjury", "using", "the", "extended", "Glasgow", "Outcome", "Scale", ";", "standardized", "assessment", "was", "facilitated", "by", "the", "use", "of", "a", "structured", "interview", ".", "Before", "initiation", "of", "trial", "centers", ",", "outcome", "ratings", "were", "obtained", "for", "sample", "cases", "to", "establish", "initial", "levels", "of", "agreement", ".", "Training", "sessions", "in", "outcome", "assessment", "were", "held", ",", "and", "problems", "in", "assigning", "outcome", "were", "investigated", ".", "During", "the", "trial", ",", "a", "process", "of", "central", "review", "was", "established", "to", "monitor", "performance", ".", "Interobserver", "variation", "was", "analyzed", "using", "the", "kappa", "statistic", ".", "RESULTS", "Substantial", "observer", "variation", "was", "found", "in", "the", "rating", "of", "sample", "cases", "(", "weighted", "kappa", ",", "0.72", ";", "confidence", "interval", ",", "0.68", "-", "0.75", ")", "and", "in", "assigning", "outcome", "based", "on", "completed", "structured", "interviews", "(", "weighted", "kappa", ",", "0.61", ";", "confidence", "interval", ",", "0.57", "-", "0.64", ")", ".", "In", "the", "early", "stages", "of", "the", "trial", ",", "a", "relatively", "large", "number", "of", "discrepancies", "(", "29", "-", "37", "%", ")", "were", "identified", "on", "central", "review", ".", "This", "number", "declined", "as", "the", "trial", "progressed", "and", "coincided", "with", "investigator", "training", "and", "feedback", "from", "central", "review", ".", "Centers", "with", "higher", "enrollment", "rates", "showed", "better", "performance", ".", "CONCLUSION", "Observer", "variation", "in", "outcome", "assessment", "is", "a", "significant", "problem", "for", "head", "injury", "trials", ".", "Consistency", "can", "be", "improved", "by", "standardizing", "procedures", ",", "training", "assessors", ",", "and", "monitoring", "the", "quality", "of", "assessments", "and", "providing", "feedback", "to", "interviewers", "." ]
[ "Outcome_Physical", "Participant_Sample-size", "Outcome_Other", "Participant_Condition", "Intervention_Control", "Intervention_Pharmacological" ]
shoulder is an umlsterm, nomenclature is an umlsterm, shoulder is an umlsterm, adhesive capsulitis is an umlsterm, algodystrophy is an umlsterm, shoulder is an umlsterm, shoulder is an umlsterm, disease is an umlsterm, trauma is an umlsterm, infection is an umlsterm, tumour is an umlsterm, radiation is an umlsterm, joint capsule is an umlsterm
DerOrthopaede.00290845.eng.abstr_task0
Sentence: Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space .
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[ "umlsterm" ]
shoulder is an umlsterm, nomenclature is an umlsterm, shoulder is an umlsterm, adhesive capsulitis is an umlsterm, algodystrophy is an umlsterm, shoulder is an umlsterm, shoulder is an umlsterm, disease is an umlsterm, trauma is an umlsterm, infection is an umlsterm, tumour is an umlsterm, radiation is an umlsterm, joint capsule is an umlsterm
DerOrthopaede.00290845.eng.abstr_task1
Sentence: Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space . Instructions: please typing these entity words according to sentence: shoulder, nomenclature, shoulder, adhesive capsulitis, algodystrophy, shoulder, shoulder, disease, trauma, infection, tumour, radiation, joint capsule Options: umlsterm
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space .
[ "Painful", "stiffness", "of", "the", "shoulder", "is", "an", "ill", "-", "defined", "clinical", "entity", "that", "is", "difficult", "to", "assess", "and", "delicate", "to", "treat", ".", "The", "nomenclature", "used", "is", "broad", "and", "includes", "terms", "such", "as", "frozen", "shoulder", ",", "adhesive", "capsulitis", ",", "focal", "algodystrophy", ",", "stiff", "shoulder", ",", "contracted", "shoulder", ",", "and", "others", ".", "Apart", "from", "its", "idiopathic", "form", ",", "the", "disease", "can", "be", "initiated", "by", "trauma", ",", "infection", ",", "tumour", ",", "radiation", ",", "systemic", "and", "local", "metabolic", "disturbances", ".", "Pathoanatomically", ",", "the", "common", "denominator", "is", "an", "inflammatory", "vascular", "proliferation", "followed", "by", "thickening", ",", "scarring", ",", "and", "retraction", "of", "the", "joint", "capsule", ".", "The", "inflammatory", "process", "often", "starts", "at", "the", "rotator", "interval", "and", "may", "extend", "to", "the", "subacromial", "space", "." ]
[ "umlsterm" ]
shoulder, nomenclature, shoulder, adhesive capsulitis, algodystrophy, shoulder, shoulder, disease, trauma, infection, tumour, radiation, joint capsule
DerOrthopaede.00290845.eng.abstr_task2
Sentence: Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Painful stiffness of the shoulder is an ill-defined clinical entity that is difficult to assess and delicate to treat . The nomenclature used is broad and includes terms such as frozen shoulder , adhesive capsulitis , focal algodystrophy , stiff shoulder , contracted shoulder , and others . Apart from its idiopathic form , the disease can be initiated by trauma , infection , tumour , radiation , systemic and local metabolic disturbances . Pathoanatomically , the common denominator is an inflammatory vascular proliferation followed by thickening , scarring , and retraction of the joint capsule . The inflammatory process often starts at the rotator interval and may extend to the subacromial space .
[ "Painful", "stiffness", "of", "the", "shoulder", "is", "an", "ill", "-", "defined", "clinical", "entity", "that", "is", "difficult", "to", "assess", "and", "delicate", "to", "treat", ".", "The", "nomenclature", "used", "is", "broad", "and", "includes", "terms", "such", "as", "frozen", "shoulder", ",", "adhesive", "capsulitis", ",", "focal", "algodystrophy", ",", "stiff", "shoulder", ",", "contracted", "shoulder", ",", "and", "others", ".", "Apart", "from", "its", "idiopathic", "form", ",", "the", "disease", "can", "be", "initiated", "by", "trauma", ",", "infection", ",", "tumour", ",", "radiation", ",", "systemic", "and", "local", "metabolic", "disturbances", ".", "Pathoanatomically", ",", "the", "common", "denominator", "is", "an", "inflammatory", "vascular", "proliferation", "followed", "by", "thickening", ",", "scarring", ",", "and", "retraction", "of", "the", "joint", "capsule", ".", "The", "inflammatory", "process", "often", "starts", "at", "the", "rotator", "interval", "and", "may", "extend", "to", "the", "subacromial", "space", "." ]
[ "umlsterm" ]
Kind is an umlsterm, Zaire is an umlsterm, Mollusca contagiosa is an umlsterm, Infektionen is an umlsterm, Mollusca contagiosa is an umlsterm, Kryptokokkose is an umlsterm, Kryptokokkose is an umlsterm, Differentialdiagnosen is an umlsterm, Histoplasmose is an umlsterm, Toxoplasmose is an umlsterm
DerHautarzt.50460799.ger.abstr_task0
Sentence: Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen .
[ "Bei", "einem", "Kind", "aus", "Zaire", "mit", "fortgeschrittener", "Aids", "-", "bedingter", "Immundefizienz", "(", "CDC", ":", "P2D1", ")", "traten", "generalisierte", "Mollusca", "contagiosa", "von", "ungewoehnlicher", "Groesse", "auf", ".", "Waehrend", "die", "Molluscum", "-", "contagiosum", "-", "Infektion", "bei", "Immunkompetenten", "meist", "selbstlimitiert", "ist", ",", "treten", "bei", "fortgeschrittener", "Immundefizienz", "disseminierte", "und", "persistierende", "Infektionen", "auf", ".", "Histologisch", "und", "immunhistochemisch", "zeigte", "sich", "eine", "starke", "Verminderung", "der", "Langerhans-", "und", "T", "-", "Zellpopulationen", ",", "die", "der", "Disseminierungstendenz", "zugrunde", "liegen", "koennen", ".", "Wegen", "ihrer", "klinischen", "Aehnlichkeit", "mit", "Mollusca", "contagiosa", "und", ",", "aufgrund", "einer", "vorausgegangenen", "systemischen", "Kryptokokkose", "im", "Laufe", "der", "Grunderkrankung", "der", "Patientin", ",", "musste", "eine", "kutane", "Kryptokokkose", "differentialdiagnostisch", "beruecksichtigt", "werden", ".", "Als", "weitere", "Differentialdiagnosen", "waren", "kutane", "Manifestationen", "der", "amerikanischen", "und", "afrikanischen", "Histoplasmose", ",", "kutane", "Toxoplasmose", "und", "Pneumocystis", "-", "carinii", "-", "Infektion", "sowie", "kutane", "Mykobakteriosen", "in", "Betracht", "zu", "ziehen", "." ]
[ "umlsterm" ]
Kind is an umlsterm, Zaire is an umlsterm, Mollusca contagiosa is an umlsterm, Infektionen is an umlsterm, Mollusca contagiosa is an umlsterm, Kryptokokkose is an umlsterm, Kryptokokkose is an umlsterm, Differentialdiagnosen is an umlsterm, Histoplasmose is an umlsterm, Toxoplasmose is an umlsterm
DerHautarzt.50460799.ger.abstr_task1
Sentence: Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen . Instructions: please typing these entity words according to sentence: Kind, Zaire, Mollusca contagiosa, Infektionen, Mollusca contagiosa, Kryptokokkose, Kryptokokkose, Differentialdiagnosen, Histoplasmose, Toxoplasmose Options: umlsterm
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Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen .
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[ "umlsterm" ]
Kind, Zaire, Mollusca contagiosa, Infektionen, Mollusca contagiosa, Kryptokokkose, Kryptokokkose, Differentialdiagnosen, Histoplasmose, Toxoplasmose
DerHautarzt.50460799.ger.abstr_task2
Sentence: Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen . Instructions: please extract entity words from the input sentence
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Bei einem Kind aus Zaire mit fortgeschrittener Aids-bedingter Immundefizienz ( CDC : P2D1) traten generalisierte Mollusca contagiosa von ungewoehnlicher Groesse auf . Waehrend die Molluscum-contagiosum-Infektion bei Immunkompetenten meist selbstlimitiert ist , treten bei fortgeschrittener Immundefizienz disseminierte und persistierende Infektionen auf . Histologisch und immunhistochemisch zeigte sich eine starke Verminderung der Langerhans- und T-Zellpopulationen , die der Disseminierungstendenz zugrunde liegen koennen . Wegen ihrer klinischen Aehnlichkeit mit Mollusca contagiosa und , aufgrund einer vorausgegangenen systemischen Kryptokokkose im Laufe der Grunderkrankung der Patientin , musste eine kutane Kryptokokkose differentialdiagnostisch beruecksichtigt werden . Als weitere Differentialdiagnosen waren kutane Manifestationen der amerikanischen und afrikanischen Histoplasmose , kutane Toxoplasmose und Pneumocystis-carinii-Infektion sowie kutane Mykobakteriosen in Betracht zu ziehen .
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[ "umlsterm" ]
Aetiologie is an umlsterm, Lateralsklerose is an umlsterm, Therapieansaetzen is an umlsterm
DerNervenarzt.70680785.ger.abstr_task0
Sentence: Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden .
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[ "umlsterm" ]
Aetiologie is an umlsterm, Lateralsklerose is an umlsterm, Therapieansaetzen is an umlsterm
DerNervenarzt.70680785.ger.abstr_task1
Sentence: Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden . Instructions: please typing these entity words according to sentence: Aetiologie, Lateralsklerose, Therapieansaetzen Options: umlsterm
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Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden .
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[ "umlsterm" ]
Aetiologie, Lateralsklerose, Therapieansaetzen
DerNervenarzt.70680785.ger.abstr_task2
Sentence: Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden . Instructions: please extract entity words from the input sentence
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Die Aetiologie und Pathogenese der amyotrophen Lateralsklerose ( ALS ) bleibt weitgehend ungeklaert . In den zurueckliegenden Jahren sind bei den genetisch bedingten Varianten dieser Erkrankung wichtige Fortschritte bei der Identifizierung ihrer molekularbiologischen Grundlagen gemacht worden . Diese Fortschritte berechtigen zu der Hoffnung , dass es in Zukunft gelingt , die Pathogenese der familiaeren , aber auch der sporadischen Formen der Erkrankung zu erhellen und damit rationalen Therapieansaetzen weiter den Weg zu bereiten . Im Rahmen dieser Uebersichtsarbeit soll sowohl auf die vorliegenden Befunde bei der familiaeren Form der ALS ( fALS ) als auch auf die moegliche Bedeutung dieser Befunde fuer pathogenetische Vorstellungen bei der sporadischen Form der ALS ( sALS ) eingegangen werden .
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[ "umlsterm" ]
growth hormone ( GH ) deficiency is a DISEASE, abdominal obesity is a DISEASE
example-231_task0
Sentence: The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DISEASE
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The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action.
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[ "DISEASE" ]
growth hormone ( GH ) deficiency is a DISEASE, abdominal obesity is a DISEASE
example-231_task1
Sentence: The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action. Instructions: please typing these entity words according to sentence: growth hormone ( GH ) deficiency, abdominal obesity Options: DISEASE
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The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action.
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[ "DISEASE" ]
growth hormone ( GH ) deficiency, abdominal obesity
example-231_task2
Sentence: The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The reduction in visceral fat mass in response to growth hormone is more marked in men than in oestrogen-deficient women. CONTEXT: Women with severe growth hormone (GH) deficiency have a less marked response to GH replacement than men. This has mostly been attributed to the attenuating effects of oestrogen replacement therapy. OBJECTIVE: To study gender related differences in the response to GH treatment in men and postmenopausal women. METHODS: Fifteen men and 15 age- and BMI-matched women with abdominal obesity (mean age: 58; range 51-64 years) were treated for one year with similar doses (0.47 vs. 0.51 mg/day) of GH. All women were postmenopausal not receiving oestrogen treatment. Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp and body composition by computed tomography (CT) scans and from total body potassium, K(40). RESULTS: Men and women were comparable at baseline in terms of waist circumference, IGF-1 and lipid levels. After one year of GH treatment, there was a 18% reduction in visceral adipose tissue (VAT) in men and a 5% reduction in women (P=0.0001 men vs. women). Although the magnitude of the difference was small, men increased more in thigh muscle mass (P<0.0001 vs. women). A reduction in thigh intermuscular adipose tissue (IMAT) and diastolic blood pressure was seen only in men (both p<0.05 vs. baseline). A decrease in LDL cholesterol, and an increase in serum insulin, was observed only in women (both p<0.05 vs. baseline). CONCLUSION: Low dose GH treatment reduced VAT more markedly in men as compared with women. As all women were postmenopausal and oestrogen-deficient, this gender difference in responsiveness was not due to an antagonistic effect of oestrogen on peripheral GH action.
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[ "DISEASE" ]
Pediatric nursing is an umlsterm, pain therapy is an umlsterm, patient is an umlsterm, labor is an umlsterm, medicine is an umlsterm, nursing is an umlsterm, forms is an umlsterm, nurses 's is an umlsterm
DerSchmerz.00140314.eng.abstr_task0
Sentence: Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O" ]
Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice .
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[ "umlsterm" ]
Pediatric nursing is an umlsterm, pain therapy is an umlsterm, patient is an umlsterm, labor is an umlsterm, medicine is an umlsterm, nursing is an umlsterm, forms is an umlsterm, nurses 's is an umlsterm
DerSchmerz.00140314.eng.abstr_task1
Sentence: Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice . Instructions: please typing these entity words according to sentence: Pediatric nursing, pain therapy, patient, labor, medicine, nursing, forms, nurses 's Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O" ]
Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice .
[ "Key", "position", ".", "Pediatric", "nursing", "owns", "a", "key", "position", "in", "pain", "therapy", ",", "due", "to", "its", "patient", "centered", "tasks", "and", "special", "kind", "of", "labor", "repartition", "between", "medicine", "and", "nursing", ".", "However", ",", "it", "is", "to", "admit", "that", "this", "key", "position", "obtains", "various", "forms", "of", "appearance", "in", "the", "different", "settings", "of", "pediatric", "nurses", "'s", "practice", "." ]
[ "umlsterm" ]
Pediatric nursing, pain therapy, patient, labor, medicine, nursing, forms, nurses 's
DerSchmerz.00140314.eng.abstr_task2
Sentence: Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice . Instructions: please extract entity words from the input sentence
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Key position . Pediatric nursing owns a key position in pain therapy , due to its patient centered tasks and special kind of labor repartition between medicine and nursing . However , it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice .
[ "Key", "position", ".", "Pediatric", "nursing", "owns", "a", "key", "position", "in", "pain", "therapy", ",", "due", "to", "its", "patient", "centered", "tasks", "and", "special", "kind", "of", "labor", "repartition", "between", "medicine", "and", "nursing", ".", "However", ",", "it", "is", "to", "admit", "that", "this", "key", "position", "obtains", "various", "forms", "of", "appearance", "in", "the", "different", "settings", "of", "pediatric", "nurses", "'s", "practice", "." ]
[ "umlsterm" ]
knowledge is an umlsterm, whiplash injury is an umlsterm, papers is an umlsterm, research is an umlsterm, pathophysiology is an umlsterm, therapy is an umlsterm
ManuelleMedizin.90370231.eng.abstr_task0
Sentence: In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed .
[ "In", "this", "article", "we", "summarize", "the", "current", "knowledge", "on", "\"", "whiplash", "injury", "\"", "by", "means", "of", "selected", "papers", "and", "our", "own", "results", ".", "The", "newest", "hypotheses", "and", "the", "results", "of", "research", "in", "pathophysiology", ",", "symptomatology", ",", "predictors", "and", "therapy", "are", "also", "discussed", "." ]
[ "umlsterm" ]
knowledge is an umlsterm, whiplash injury is an umlsterm, papers is an umlsterm, research is an umlsterm, pathophysiology is an umlsterm, therapy is an umlsterm
ManuelleMedizin.90370231.eng.abstr_task1
Sentence: In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed . Instructions: please typing these entity words according to sentence: knowledge, whiplash injury, papers, research, pathophysiology, therapy Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed .
[ "In", "this", "article", "we", "summarize", "the", "current", "knowledge", "on", "\"", "whiplash", "injury", "\"", "by", "means", "of", "selected", "papers", "and", "our", "own", "results", ".", "The", "newest", "hypotheses", "and", "the", "results", "of", "research", "in", "pathophysiology", ",", "symptomatology", ",", "predictors", "and", "therapy", "are", "also", "discussed", "." ]
[ "umlsterm" ]
knowledge, whiplash injury, papers, research, pathophysiology, therapy
ManuelleMedizin.90370231.eng.abstr_task2
Sentence: In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]
In this article we summarize the current knowledge on " whiplash injury " by means of selected papers and our own results . The newest hypotheses and the results of research in pathophysiology , symptomatology , predictors and therapy are also discussed .
[ "In", "this", "article", "we", "summarize", "the", "current", "knowledge", "on", "\"", "whiplash", "injury", "\"", "by", "means", "of", "selected", "papers", "and", "our", "own", "results", ".", "The", "newest", "hypotheses", "and", "the", "results", "of", "research", "in", "pathophysiology", ",", "symptomatology", ",", "predictors", "and", "therapy", "are", "also", "discussed", "." ]
[ "umlsterm" ]
factor IX is a Protein, Factor IX is a Protein, aspartic acid at residue 64 is a Entity, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, aspartic acid 64 is a Entity, Factor IX is a Protein
218_task0
Sentence: Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
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Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide.
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[ "Entity", "Protein" ]
factor IX is a Protein, Factor IX is a Protein, aspartic acid at residue 64 is a Entity, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, Factor IX is a Protein, aspartic acid 64 is a Entity, Factor IX is a Protein
218_task1
Sentence: Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide. Instructions: please typing these entity words according to sentence: factor IX, Factor IX, aspartic acid at residue 64, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, aspartic acid 64, Factor IX Options: Entity, Protein
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Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide.
[ "Effect", "of", "propeptide", "mutations", "on", "post", "-", "translational", "processing", "of", "factor", "IX", ".", "Evidence", "that", "beta", "-", "hydroxylation", "and", "gamma", "-", "carboxylation", "are", "independent", "events", ".", "\n", "Post", "-", "translational", "processing", "of", "Factor", "IX", "includes", "glycosylation", ",", "cleavage", "of", "the", "signal", "peptide", "and", "propeptide", ",", "vitamin", "K", "-", "dependent", "carboxylation", "of", "specific", "glutamic", "acid", "residues", "to", "form", "gamma", "-", "carboxyglutamic", "acid", ",", "and", "beta", "-", "hydroxylation", "of", "aspartic", "acid", "at", "residue", "64", "to", "form", "beta", "-", "hydroxyaspartic", "acid", ".", "The", "human", "Factor", "IX", "cDNA", "coding", "sequence", "was", "modified", "in", "the", "propeptide", "region", "(", "residue", "-18", "to", "-1", ")", "using", "oligonucleotide", "-", "directed", "site", "-", "specific", "mutagenesis", ",", "and", "the", "altered", "Factor", "IX", "cDNA", "was", "expressed", "in", "Chinese", "hamster", "ovary", "cells", ".", "The", "effects", "of", "the", "mutations", "on", "proteolytic", "processing", ",", "gamma", "-", "carboxylation", ",", "and", "beta", "-", "hydroxylation", "were", "assessed", "by", "direct", "structural", "analysis", ".", "After", "purification", ",", "the", "molecular", "weight", "of", "each", "of", "the", "recombinant", "Factor", "IX", "species", "and", "its", "NH2-terminal", "amino", "acid", "sequence", "were", "shown", "to", "be", "identical", "to", "those", "of", "plasma", "Factor", "IX", ".", "gamma", "-", "Carboxyglutamic", "acid", "and", "beta", "-", "hydroxyaspartic", "acid", "analyses", "revealed", "that", "recombinant", "wild", "-", "type", "Factor", "IX", "contained", "9.2", "gamma", "-", "carboxyglutamic", "acid", "and", "0.3", "beta", "-", "hydroxyaspartic", "acid", "residues", "/", "molecule", "compared", "with", "11.4", "gamma", "-", "carboxyglutamic", "acid", "and", "0.39", "beta", "-", "hydroxyaspartic", "acid", "residues", "in", "plasma", "Factor", "IX", ".", "When", "the", "18-residue", "propeptide", "was", "deleted", "or", "when", "the", "cells", "were", "grown", "in", "the", "presence", "of", "sodium", "warfarin", ",", "secreted", "Factor", "IX", "contained", "no", "detectable", "gamma", "-", "carboxyglutamic", "acid", "but", "0.36", "and", "0.40", "residues", "of", "beta", "-", "hydroxyaspartic", "acid", ",", "respectively", ".", "Point", "mutations", "leading", "to", "substitution", "of", "alanine", "for", "phenylalanine", "at", "residue", "-16", "or", "glutamic", "acid", "for", "alanine", "at", "residue", "-10", "contained", "0.2", "and", "1.7", "gamma", "-", "carboxyglutamic", "acid", "residues", ",", "respectively", ",", "and", "0.2", "residues", "of", "beta", "-", "hydroxyaspartic", "acid", ".", "These", "data", "confirm", "that", "the", "propeptide", "mutations", "made", "do", "not", "interfere", "with", "proteolytic", "processing", "and", "that", "the", "Factor", "IX", "propeptide", "contains", "a", "recognition", "site", "that", "designates", "the", "adjacent", "glutamic", "acid", "-", "rich", "domain", "for", "gamma", "-", "carboxylation", ".", "In", "contrast", ",", "beta", "-", "hydroxylation", "of", "aspartic", "acid", "64", "is", "an", "independent", "process", "which", "does", "not", "require", "vitamin", "K", "and", "is", "mediated", "through", "a", "hydroxylation", "recognition", "site", "in", "the", "mature", "Factor", "IX", ",", "not", "in", "the", "propeptide", "." ]
[ "Entity", "Protein" ]
factor IX, Factor IX, aspartic acid at residue 64, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, Factor IX, aspartic acid 64, Factor IX
218_task2
Sentence: Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O" ]
Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events. Post-translational processing of Factor IX includes glycosylation, cleavage of the signal peptide and propeptide, vitamin K-dependent carboxylation of specific glutamic acid residues to form gamma-carboxyglutamic acid, and beta-hydroxylation of aspartic acid at residue 64 to form beta-hydroxyaspartic acid. The human Factor IX cDNA coding sequence was modified in the propeptide region (residue -18 to -1) using oligonucleotide-directed site-specific mutagenesis, and the altered Factor IX cDNA was expressed in Chinese hamster ovary cells. The effects of the mutations on proteolytic processing, gamma-carboxylation, and beta-hydroxylation were assessed by direct structural analysis. After purification, the molecular weight of each of the recombinant Factor IX species and its NH2-terminal amino acid sequence were shown to be identical to those of plasma Factor IX. gamma-Carboxyglutamic acid and beta-hydroxyaspartic acid analyses revealed that recombinant wild-type Factor IX contained 9.2 gamma-carboxyglutamic acid and 0.3 beta-hydroxyaspartic acid residues/molecule compared with 11.4 gamma-carboxyglutamic acid and 0.39 beta-hydroxyaspartic acid residues in plasma Factor IX. When the 18-residue propeptide was deleted or when the cells were grown in the presence of sodium warfarin, secreted Factor IX contained no detectable gamma-carboxyglutamic acid but 0.36 and 0.40 residues of beta-hydroxyaspartic acid, respectively. Point mutations leading to substitution of alanine for phenylalanine at residue -16 or glutamic acid for alanine at residue -10 contained 0.2 and 1.7 gamma-carboxyglutamic acid residues, respectively, and 0.2 residues of beta-hydroxyaspartic acid. These data confirm that the propeptide mutations made do not interfere with proteolytic processing and that the Factor IX propeptide contains a recognition site that designates the adjacent glutamic acid-rich domain for gamma-carboxylation. In contrast, beta-hydroxylation of aspartic acid 64 is an independent process which does not require vitamin K and is mediated through a hydroxylation recognition site in the mature Factor IX, not in the propeptide.
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[ "Entity", "Protein" ]
HDL is a Genes & Molecular Sequences, serum PON1 is a Genes & Molecular Sequences, lipolactonase is a Genes & Molecular Sequences
2258_task0
Sentence: The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes & Molecular Sequences
[ "O", "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "O", "O" ]
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity.
[ "The", "development", "of", "human", "sera", "tests", "for", "HDL", "-", "bound", "serum", "PON1", "and", "its", "lipolactonase", "activity", "." ]
[ "Chemicals & Drugs", "", "Genes & Molecular Sequences", "SNP & Sequence variations" ]
HDL is a Genes & Molecular Sequences, serum PON1 is a Genes & Molecular Sequences, lipolactonase is a Genes & Molecular Sequences
2258_task1
Sentence: The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity. Instructions: please typing these entity words according to sentence: HDL, serum PON1, lipolactonase Options: Genes & Molecular Sequences
[ "O", "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "O", "O" ]
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity.
[ "The", "development", "of", "human", "sera", "tests", "for", "HDL", "-", "bound", "serum", "PON1", "and", "its", "lipolactonase", "activity", "." ]
[ "Chemicals & Drugs", "", "Genes & Molecular Sequences", "SNP & Sequence variations" ]
HDL, serum PON1, lipolactonase
2258_task2
Sentence: The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "B-Genes & Molecular Sequences", "O", "O" ]
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity.
[ "The", "development", "of", "human", "sera", "tests", "for", "HDL", "-", "bound", "serum", "PON1", "and", "its", "lipolactonase", "activity", "." ]
[ "Chemicals & Drugs", "", "Genes & Molecular Sequences", "SNP & Sequence variations" ]
human myeloid cell nuclear differentiation antigen gene promoter is a DNA_domain_or_region
21967_task0
Sentence: Characterization of the human myeloid cell nuclear differentiation antigen gene promoter. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region
[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.
[ "Characterization", "of", "the", "human", "myeloid", "cell", "nuclear", "differentiation", "antigen", "gene", "promoter", "." ]
[ "DNA_domain_or_region", "protein_molecule", "other_name", "protein_family_or_group", "DNA_family_or_group", "cell_type", "polynucleotide" ]
human myeloid cell nuclear differentiation antigen gene promoter is a DNA_domain_or_region
21967_task1
Sentence: Characterization of the human myeloid cell nuclear differentiation antigen gene promoter. Instructions: please typing these entity words according to sentence: human myeloid cell nuclear differentiation antigen gene promoter Options: DNA_domain_or_region
[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.
[ "Characterization", "of", "the", "human", "myeloid", "cell", "nuclear", "differentiation", "antigen", "gene", "promoter", "." ]
[ "DNA_domain_or_region", "protein_molecule", "other_name", "protein_family_or_group", "DNA_family_or_group", "cell_type", "polynucleotide" ]
human myeloid cell nuclear differentiation antigen gene promoter
21967_task2
Sentence: Characterization of the human myeloid cell nuclear differentiation antigen gene promoter. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]
Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.
[ "Characterization", "of", "the", "human", "myeloid", "cell", "nuclear", "differentiation", "antigen", "gene", "promoter", "." ]
[ "DNA_domain_or_region", "protein_molecule", "other_name", "protein_family_or_group", "DNA_family_or_group", "cell_type", "polynucleotide" ]
Behandlung is an umlsterm, Phakoemulsifikation is an umlsterm, Hinterkammerlinsenimplantation is an umlsterm, Patienten is an umlsterm, Flurbiprofen is an umlsterm, Patienten is an umlsterm, Flurbiprofen is an umlsterm, Augenbereich is an umlsterm, Diclofenac is an umlsterm, Kataraktoperation is an umlsterm, Flurbiprofen is an umlsterm, Flurbiprofen is an umlsterm
DerOpthalmologe.70940033.ger.abstr_task0
Sentence: In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin .
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[ "umlsterm" ]
Behandlung is an umlsterm, Phakoemulsifikation is an umlsterm, Hinterkammerlinsenimplantation is an umlsterm, Patienten is an umlsterm, Flurbiprofen is an umlsterm, Patienten is an umlsterm, Flurbiprofen is an umlsterm, Augenbereich is an umlsterm, Diclofenac is an umlsterm, Kataraktoperation is an umlsterm, Flurbiprofen is an umlsterm, Flurbiprofen is an umlsterm
DerOpthalmologe.70940033.ger.abstr_task1
Sentence: In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin . Instructions: please typing these entity words according to sentence: Behandlung, Phakoemulsifikation, Hinterkammerlinsenimplantation, Patienten, Flurbiprofen, Patienten, Flurbiprofen, Augenbereich, Diclofenac, Kataraktoperation, Flurbiprofen, Flurbiprofen Options: umlsterm
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In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin .
[ "In", "der", "vorliegenden", "prospektiven", ",", "randomisierten", "und", "vergleichenden", "doppelt", "maskierten", "Studie", "wurde", "der", "entzuendungshemmende", "Effekt", "von", "Diclofenac-0,1%-", "Flurbiprofen-0,03%-", "und", "Indomethacin-", "1,0%-Augentropfen", "bei", "der", "postoperativen", "Behandlung", "nach", "Phakoemulsifikation", "mit", "Hinterkammerlinsenimplantation", "an", "99", "Patienten", "untersucht", ".", "Die", "Differenz", "zwischen", "den", "am", "1", ".", "und", "am", "4", ".", "bis", "5", ".", "postoperativen", "Tag", "mit", "einem", "Laser", "-", "flare", "-", "Meter", "FM-500", "(", "Fa", ".", "KOWA", ")", "gemessenen", "Flare", "-", "Werten", "in", "der", "Vorderkammer", "war", "in", "der", "Diclofenacgruppe", "signifikant", "groesser", "als", "bei", "den", "mit", "Flurbiprofen", "behandelten", "Probanden", "(", "p", "=", "0,022", ")", ".", "Zusaetzlich", "gaben", "die", "Patienten", "der", "Diclofenacgruppe", "verglichen", "mit", "Flurbiprofen", "und", "Indomethacin", "signifikant", "weniger", "Brennen", "und", "Stechen", "im", "Augenbereich", "an", "(", "4", ".", "bis", "5", ".", "Tag", ":", "p", "0,0001", ";", "12", ".", "bis", "14", ".", "Tag", ":", "p", "=", "0,001", ")", ".", "Zusammenfassend", "scheint", "Diclofenac", "den", "postoperativen", "Intraokularreiz", "nach", "Kataraktoperation", "mehr", "zu", "reduzieren", "als", "Flurbiprofen", "und", "bietet", "zusaetzlich", "den", "Vorteil", "einer", "besseren", "lokalen", "Vertraeglichkeit", "als", "Flurbiprofen", "und", "Indomethacin", "." ]
[ "umlsterm" ]
Behandlung, Phakoemulsifikation, Hinterkammerlinsenimplantation, Patienten, Flurbiprofen, Patienten, Flurbiprofen, Augenbereich, Diclofenac, Kataraktoperation, Flurbiprofen, Flurbiprofen
DerOpthalmologe.70940033.ger.abstr_task2
Sentence: In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
In der vorliegenden prospektiven , randomisierten und vergleichenden doppelt maskierten Studie wurde der entzuendungshemmende Effekt von Diclofenac-0,1%- Flurbiprofen-0,03%- und Indomethacin- 1,0%-Augentropfen bei der postoperativen Behandlung nach Phakoemulsifikation mit Hinterkammerlinsenimplantation an 99 Patienten untersucht . Die Differenz zwischen den am 1. und am 4. bis 5. postoperativen Tag mit einem Laser-flare-Meter FM-500 ( Fa. KOWA ) gemessenen Flare-Werten in der Vorderkammer war in der Diclofenacgruppe signifikant groesser als bei den mit Flurbiprofen behandelten Probanden ( p = 0,022 ) . Zusaetzlich gaben die Patienten der Diclofenacgruppe verglichen mit Flurbiprofen und Indomethacin signifikant weniger Brennen und Stechen im Augenbereich an ( 4. bis 5. Tag : p 0,0001 ; 12. bis 14. Tag : p = 0,001 ) . Zusammenfassend scheint Diclofenac den postoperativen Intraokularreiz nach Kataraktoperation mehr zu reduzieren als Flurbiprofen und bietet zusaetzlich den Vorteil einer besseren lokalen Vertraeglichkeit als Flurbiprofen und Indomethacin .
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[ "umlsterm" ]
hyaluronan is a compound, HA synthases is a protein, HAS1 is a protein, HAS2 is a protein, HAS3 is a protein
DS.d1715_task0
Sentence: In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O" ]
In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.
[ "In", "this", "study", ",", "we", "evaluated", "the", "distribution", "of", "the", "principal", "CD44", "ligand", "hyaluronan", "(", "HA", ")", "and", "the", "expressions", "of", "HA", "synthases", "(", "HAS", ":", "HAS1", ",", "HAS2", ",", "and", "HAS3", ")", "during", "atresia", "in", "pig", "ovaries", "." ]
[ "protein", "compound" ]
hyaluronan is a compound, HA synthases is a protein, HAS1 is a protein, HAS2 is a protein, HAS3 is a protein
DS.d1715_task1
Sentence: In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries. Instructions: please typing these entity words according to sentence: hyaluronan, HA synthases, HAS1, HAS2, HAS3 Options: compound, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O" ]
In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.
[ "In", "this", "study", ",", "we", "evaluated", "the", "distribution", "of", "the", "principal", "CD44", "ligand", "hyaluronan", "(", "HA", ")", "and", "the", "expressions", "of", "HA", "synthases", "(", "HAS", ":", "HAS1", ",", "HAS2", ",", "and", "HAS3", ")", "during", "atresia", "in", "pig", "ovaries", "." ]
[ "protein", "compound" ]
hyaluronan, HA synthases, HAS1, HAS2, HAS3
DS.d1715_task2
Sentence: In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O" ]
In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.
[ "In", "this", "study", ",", "we", "evaluated", "the", "distribution", "of", "the", "principal", "CD44", "ligand", "hyaluronan", "(", "HA", ")", "and", "the", "expressions", "of", "HA", "synthases", "(", "HAS", ":", "HAS1", ",", "HAS2", ",", "and", "HAS3", ")", "during", "atresia", "in", "pig", "ovaries", "." ]
[ "protein", "compound" ]
idarubicin is a compound
DS.d736_task0
Sentence: Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O" ]
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
[ "Ligand", "-", "induced", "Flt3-downregulation", "modulates", "cell", "death", "associated", "proteins", "and", "enhances", "chemosensitivity", "to", "idarubicin", "in", "THP-1", "acute", "myeloid", "leukemia", "cells", "." ]
[ "compound", "protein" ]
idarubicin is a compound
DS.d736_task1
Sentence: Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Instructions: please typing these entity words according to sentence: idarubicin Options: compound
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O" ]
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
[ "Ligand", "-", "induced", "Flt3-downregulation", "modulates", "cell", "death", "associated", "proteins", "and", "enhances", "chemosensitivity", "to", "idarubicin", "in", "THP-1", "acute", "myeloid", "leukemia", "cells", "." ]
[ "compound", "protein" ]
idarubicin
DS.d736_task2
Sentence: Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O" ]
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
[ "Ligand", "-", "induced", "Flt3-downregulation", "modulates", "cell", "death", "associated", "proteins", "and", "enhances", "chemosensitivity", "to", "idarubicin", "in", "THP-1", "acute", "myeloid", "leukemia", "cells", "." ]
[ "compound", "protein" ]
open is an umlsterm, clinical trials is an umlsterm, intravenous immunoglobulin is an umlsterm, treatment is an umlsterm, multiple sclerosis is an umlsterm, Immunoglobulin is an umlsterm, Multiple Sclerosis is an umlsterm, AIMS is an umlsterm, patients is an umlsterm, placebo is an umlsterm, placebo is an umlsterm, administration is an umlsterm, period is an umlsterm, patients is an umlsterm, relapses is an umlsterm, placebo is an umlsterm, treatment is an umlsterm, Therapeutic is an umlsterm, treatment is an umlsterm, assistance is an umlsterm, treatment is an umlsterm, beta - interferon is an umlsterm, future is an umlsterm, role is an umlsterm, treatment is an umlsterm, forms is an umlsterm, disease is an umlsterm
DerNervenarzt.80690361.eng.abstr_task0
Sentence: Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease .
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[ "umlsterm" ]
open is an umlsterm, clinical trials is an umlsterm, intravenous immunoglobulin is an umlsterm, treatment is an umlsterm, multiple sclerosis is an umlsterm, Immunoglobulin is an umlsterm, Multiple Sclerosis is an umlsterm, AIMS is an umlsterm, patients is an umlsterm, placebo is an umlsterm, placebo is an umlsterm, administration is an umlsterm, period is an umlsterm, patients is an umlsterm, relapses is an umlsterm, placebo is an umlsterm, treatment is an umlsterm, Therapeutic is an umlsterm, treatment is an umlsterm, assistance is an umlsterm, treatment is an umlsterm, beta - interferon is an umlsterm, future is an umlsterm, role is an umlsterm, treatment is an umlsterm, forms is an umlsterm, disease is an umlsterm
DerNervenarzt.80690361.eng.abstr_task1
Sentence: Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease . Instructions: please typing these entity words according to sentence: open, clinical trials, intravenous immunoglobulin, treatment, multiple sclerosis, Immunoglobulin, Multiple Sclerosis, AIMS, patients, placebo, placebo, administration, period, patients, relapses, placebo, treatment, Therapeutic, treatment, assistance, treatment, beta - interferon, future, role, treatment, forms, disease Options: umlsterm
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Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease .
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[ "umlsterm" ]
open, clinical trials, intravenous immunoglobulin, treatment, multiple sclerosis, Immunoglobulin, Multiple Sclerosis, AIMS, patients, placebo, placebo, administration, period, patients, relapses, placebo, treatment, Therapeutic, treatment, assistance, treatment, beta - interferon, future, role, treatment, forms, disease
DerNervenarzt.80690361.eng.abstr_task2
Sentence: Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease . Instructions: please extract entity words from the input sentence
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Experimental studies and open clinical trials have suggested intravenous immunoglobulin ( IVIg ) as a potentially effective treatment of multiple sclerosis ( MS ) . The Austrian Immunoglobulin in Multiple Sclerosis ( AIMS ) study tested this assumption by examining 148 patients with relapsing-remitting MS in a randomized , double-blind , placebo controlled fashion ( 75 IVIg , 73 placebo ) . Monthly administration of IVIg in a dosage of 0.15-0.20 g/kg over a period of 2 years slowed the progression of or even reversed disability as evident in a total of 24% of patients and almost halved the number of relapses in comparison to placebo treatment . Therapeutic efficacy was noted within the first 6 months of treatment and was not correlated to the severity of disability ( mild neurological sins without disability to ambulatory with assistance ) at study entry . Overall the magnitude of treatment effects of IVIg was comparable to that reported for beta-interferon and copolymer 1. Further ongoing studies will have to clarify the future role of IVIg in the treatment of MS , in particular in the progressive forms of the disease .
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[ "umlsterm" ]
euthanasia is an umlsterm, man is an umlsterm, dementia is an umlsterm, work is an umlsterm, measures is an umlsterm, treatment is an umlsterm
DerNervenarzt.70680907.eng.abstr_task0
Sentence: This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]
This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process .
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[ "umlsterm" ]
euthanasia is an umlsterm, man is an umlsterm, dementia is an umlsterm, work is an umlsterm, measures is an umlsterm, treatment is an umlsterm
DerNervenarzt.70680907.eng.abstr_task1
Sentence: This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process . Instructions: please typing these entity words according to sentence: euthanasia, man, dementia, work, measures, treatment Options: umlsterm
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This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process .
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[ "umlsterm" ]
euthanasia, man, dementia, work, measures, treatment
DerNervenarzt.70680907.eng.abstr_task2
Sentence: This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]
This article discusses the problem of euthanasia presenting the case of an 82-year-old man with progressive dementia . Difficulties encountered during daily clinical work are described and analysed , in order to clarify decisions on ethical , legal and professional medical grounds . General decisions concerning life-sustaining measures may be qualitatively improved if the situation of the individual is constantly assessed and considered within the treatment process .
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[ "umlsterm" ]
rad5 is a Gene/protein/RNA, rad18 is a Gene/protein/RNA, RAD1 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA, RAD52 is a Gene/protein/RNA, RAD5 is a Gene/protein/RNA
717_task0
Sentence: The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O" ]
The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes.
[ "The", "high", "recombination", "levels", "seen", "in", "rad5", "and", "rad18", "mutants", "is", "dependent", "on", "the", "RAD1", ",", "RAD51", ",", "RAD52", ",", "and", "RAD5", "genes", "." ]
[ "Gene/protein/RNA" ]
rad5 is a Gene/protein/RNA, rad18 is a Gene/protein/RNA, RAD1 is a Gene/protein/RNA, RAD51 is a Gene/protein/RNA, RAD52 is a Gene/protein/RNA, RAD5 is a Gene/protein/RNA
717_task1
Sentence: The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes. Instructions: please typing these entity words according to sentence: rad5, rad18, RAD1, RAD51, RAD52, RAD5 Options: Gene/protein/RNA
[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O" ]
The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes.
[ "The", "high", "recombination", "levels", "seen", "in", "rad5", "and", "rad18", "mutants", "is", "dependent", "on", "the", "RAD1", ",", "RAD51", ",", "RAD52", ",", "and", "RAD5", "genes", "." ]
[ "Gene/protein/RNA" ]
rad5, rad18, RAD1, RAD51, RAD52, RAD5
717_task2
Sentence: The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "B-Gene/protein/RNA", "O", "O" ]
The high recombination levels seen in rad5 and rad18 mutants is dependent on the RAD1, RAD51, RAD52, and RAD5 genes.
[ "The", "high", "recombination", "levels", "seen", "in", "rad5", "and", "rad18", "mutants", "is", "dependent", "on", "the", "RAD1", ",", "RAD51", ",", "RAD52", ",", "and", "RAD5", "genes", "." ]
[ "Gene/protein/RNA" ]
glimepiride is a CHEMICAL, glibenclamide is a CHEMICAL, sulfonylurea receptor is a GENE-N
8172912_task0
Sentence: Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL
[ "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics.
[ "Differential", "interaction", "of", "glimepiride", "and", "glibenclamide", "with", "the", "beta", "-", "cell", "sulfonylurea", "receptor", ".", "I.", "Binding", "characteristics", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
glimepiride is a CHEMICAL, glibenclamide is a CHEMICAL, sulfonylurea receptor is a GENE-N
8172912_task1
Sentence: Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics. Instructions: please typing these entity words according to sentence: glimepiride, glibenclamide, sulfonylurea receptor Options: GENE-N, CHEMICAL
[ "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics.
[ "Differential", "interaction", "of", "glimepiride", "and", "glibenclamide", "with", "the", "beta", "-", "cell", "sulfonylurea", "receptor", ".", "I.", "Binding", "characteristics", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
glimepiride, glibenclamide, sulfonylurea receptor
8172912_task2
Sentence: Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]
Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics.
[ "Differential", "interaction", "of", "glimepiride", "and", "glibenclamide", "with", "the", "beta", "-", "cell", "sulfonylurea", "receptor", ".", "I.", "Binding", "characteristics", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Ultrasonography is an umlsterm, surgery is an umlsterm, first - choice is an umlsterm, diagnostic is an umlsterm, tissue is an umlsterm, head is an umlsterm, neck is an umlsterm, date is an umlsterm, sonography is an umlsterm, maxillary sinus is an umlsterm, children is an umlsterm, pregnant women is an umlsterm, sonography is an umlsterm, assessment is an umlsterm, lymph nodes is an umlsterm, sensitivity is an umlsterm, diseases is an umlsterm, salivary glands is an umlsterm, tumors is an umlsterm, distraction osteogenesis is an umlsterm, mandible is an umlsterm, ultrasonography is an umlsterm, blood is an umlsterm, vessels is an umlsterm, head is an umlsterm, neck is an umlsterm, flaps is an umlsterm, secondary is an umlsterm, blood is an umlsterm, tissue is an umlsterm, analysis is an umlsterm, techniques is an umlsterm, lymph nodes is an umlsterm, sonography is an umlsterm, contrast is an umlsterm, technologies is an umlsterm, diagnostic is an umlsterm, head is an umlsterm, neck is an umlsterm, ultrasonography is an umlsterm
MundKieferGesichtschirurgie.0004s375.eng.abstr_task0
Sentence: Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]
Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography .
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[ "umlsterm" ]
Ultrasonography is an umlsterm, surgery is an umlsterm, first - choice is an umlsterm, diagnostic is an umlsterm, tissue is an umlsterm, head is an umlsterm, neck is an umlsterm, date is an umlsterm, sonography is an umlsterm, maxillary sinus is an umlsterm, children is an umlsterm, pregnant women is an umlsterm, sonography is an umlsterm, assessment is an umlsterm, lymph nodes is an umlsterm, sensitivity is an umlsterm, diseases is an umlsterm, salivary glands is an umlsterm, tumors is an umlsterm, distraction osteogenesis is an umlsterm, mandible is an umlsterm, ultrasonography is an umlsterm, blood is an umlsterm, vessels is an umlsterm, head is an umlsterm, neck is an umlsterm, flaps is an umlsterm, secondary is an umlsterm, blood is an umlsterm, tissue is an umlsterm, analysis is an umlsterm, techniques is an umlsterm, lymph nodes is an umlsterm, sonography is an umlsterm, contrast is an umlsterm, technologies is an umlsterm, diagnostic is an umlsterm, head is an umlsterm, neck is an umlsterm, ultrasonography is an umlsterm
MundKieferGesichtschirurgie.0004s375.eng.abstr_task1
Sentence: Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography . Instructions: please typing these entity words according to sentence: Ultrasonography, surgery, first - choice, diagnostic, tissue, head, neck, date, sonography, maxillary sinus, children, pregnant women, sonography, assessment, lymph nodes, sensitivity, diseases, salivary glands, tumors, distraction osteogenesis, mandible, ultrasonography, blood, vessels, head, neck, flaps, secondary, blood, tissue, analysis, techniques, lymph nodes, sonography, contrast, technologies, diagnostic, head, neck, ultrasonography Options: umlsterm
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Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography .
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[ "umlsterm" ]
Ultrasonography, surgery, first - choice, diagnostic, tissue, head, neck, date, sonography, maxillary sinus, children, pregnant women, sonography, assessment, lymph nodes, sensitivity, diseases, salivary glands, tumors, distraction osteogenesis, mandible, ultrasonography, blood, vessels, head, neck, flaps, secondary, blood, tissue, analysis, techniques, lymph nodes, sonography, contrast, technologies, diagnostic, head, neck, ultrasonography
MundKieferGesichtschirurgie.0004s375.eng.abstr_task2
Sentence: Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography . Instructions: please extract entity words from the input sentence
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Ultrasonography has gained acceptance in maxillofacial surgery as a first-choice diagnostic tool in soft tissue masses of the head and neck . To date , A-mode sonography of the maxillary sinus is only performed in children and pregnant women . However , B-mode sonography is primarily performed in the assessment of all cervical lymph nodes because of its superior sensitivity in comparison to CT and MR , as well as in diseases of the salivary glands , solid tumors , and monitoring of distraction osteogenesis of the mandible . With color-coded ultrasonography as a combination of B-mode and blood flow information , vessels of the head and neck area or of planned flaps can be examined in a noninvasive manner . This is especially important in secondary microsurgical reconstructions . Moreover , the blood flow in any soft tissue masses can be evaluated . In spite of all texture and image analysis techniques , positive and negative lymph nodes cannot be differentiated in a safe manner . Three-dimensional sonography , e . g . , panoramic pictures , and contrast enhancement are new technologies that will improve diagnostic accuracy of head and neck ultrasonography .
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[ "umlsterm" ]
torso weighting is a Intervention_Physical, upright mobility is a Outcome_Physical, multiple sclerosis is a Participant_Condition, parameters for weighting is a Outcome_Physical, balance - based torso weighting ( BBTW ) is a Intervention_Physical, 36 is a Participant_Sample-size, timed up and go ( TUG ) is a Outcome_Physical, sharpened Romberg is a Outcome_Physical, 360-degree turns is a Outcome_Physical, 25-foot walk , is a Outcome_Physical, computerized platform posturography is a Intervention_Physical, balance loss is a Outcome_Physical, gait velocity is a Outcome_Physical, functional activity is a Outcome_Physical, MS is a Participant_Condition
40394_task0
Sentence: Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size
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Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
torso weighting is a Intervention_Physical, upright mobility is a Outcome_Physical, multiple sclerosis is a Participant_Condition, parameters for weighting is a Outcome_Physical, balance - based torso weighting ( BBTW ) is a Intervention_Physical, 36 is a Participant_Sample-size, timed up and go ( TUG ) is a Outcome_Physical, sharpened Romberg is a Outcome_Physical, 360-degree turns is a Outcome_Physical, 25-foot walk , is a Outcome_Physical, computerized platform posturography is a Intervention_Physical, balance loss is a Outcome_Physical, gait velocity is a Outcome_Physical, functional activity is a Outcome_Physical, MS is a Participant_Condition
40394_task1
Sentence: Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities . Instructions: please typing these entity words according to sentence: torso weighting, upright mobility, multiple sclerosis, parameters for weighting, balance - based torso weighting ( BBTW ), 36, timed up and go ( TUG ), sharpened Romberg, 360-degree turns, 25-foot walk ,, computerized platform posturography, balance loss, gait velocity, functional activity, MS Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size
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Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
torso weighting, upright mobility, multiple sclerosis, parameters for weighting, balance - based torso weighting ( BBTW ), 36, timed up and go ( TUG ), sharpened Romberg, 360-degree turns, 25-foot walk ,, computerized platform posturography, balance loss, gait velocity, functional activity, MS
40394_task2
Sentence: Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities . Instructions: please extract entity words from the input sentence
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Randomized clinical trial of balance-based torso weighting for improving upright mobility in people with multiple sclerosis . BACKGROUND Torso weighting has sometimes been effective for improving upright mobility in people with multiple sclerosis , but parameters for weighting have been inconsistent . OBJECTIVE To determine whether balance-based torso weighting ( BBTW ) has immediate effects on upright mobility in people with multiple sclerosis . METHODS This was a 2-phase randomized clinical trial . In phase 1 , 36 participants were randomly assigned to experimental and control groups . In phase 2 , the control group was subsequently randomized into 2 groups with alternate weight-placement . Tests of upright mobility included : timed up and go ( TUG ) , sharpened Romberg , 360-degree turns , 25-foot walk , and computerized platform posturography . Participants were tested at baseline and again with weights placed according to group membership . In both phases , a physical therapist assessed balance for the BBTW group and then placed weights to decrease balance loss . In phase 1 , the control group had no weights placed . In phase 2 , the alternate treatment group received standard weight placement of 1.5 % body weight . RESULTS People with BBTW showed a significant improvement in the 25-foot walk ( P = .01 ) over those with no weight , and the TUG ( P = .01 ) over those with standard weight placement . BBTW participants received an average of 0.5 kg , less than 1.5 % of any participant 's body weight . CONCLUSION BBTW can have immediate advantages over a nonweighted condition for gait velocity and over a standardized weighted condition for a functional activity in people with multiple sclerosis ( MS ) who are ambulatory but have balance and mobility abnormalities .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
Craniomandibular disorders is an umlsterm, pain is an umlsterm, head is an umlsterm, face is an umlsterm, assessment is an umlsterm, diseases is an umlsterm, head is an umlsterm, facial pain is an umlsterm, knowledge is an umlsterm, equipment is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, dysfunction is an umlsterm, signs is an umlsterm, equipment is an umlsterm, general practice is an umlsterm, general practitioners is an umlsterm, method is an umlsterm, screening is an umlsterm, methods is an umlsterm, tests is an umlsterm, questionnaire is an umlsterm, elements is an umlsterm, assessment is an umlsterm, signs is an umlsterm, craniomandibular disorders is an umlsterm, dysfunction is an umlsterm, diagnosis is an umlsterm, consultation is an umlsterm, specialist is an umlsterm
DerSchmerz.70110079.eng.abstr_task0
Sentence: Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist .
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[ "umlsterm" ]
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DerSchmerz.70110079.eng.abstr_task1
Sentence: Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist . Instructions: please typing these entity words according to sentence: Craniomandibular disorders, pain, head, face, assessment, diseases, head, facial pain, knowledge, equipment, diagnosis, therapy, dysfunction, signs, equipment, general practice, general practitioners, method, screening, methods, tests, questionnaire, elements, assessment, signs, craniomandibular disorders, dysfunction, diagnosis, consultation, specialist Options: umlsterm
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Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist .
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[ "umlsterm" ]
Craniomandibular disorders, pain, head, face, assessment, diseases, head, facial pain, knowledge, equipment, diagnosis, therapy, dysfunction, signs, equipment, general practice, general practitioners, method, screening, methods, tests, questionnaire, elements, assessment, signs, craniomandibular disorders, dysfunction, diagnosis, consultation, specialist
DerSchmerz.70110079.eng.abstr_task2
Sentence: Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist . Instructions: please extract entity words from the input sentence
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Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist .
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[ "umlsterm" ]
Hyperimmunoglobulin E syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, disorder is an umlsterm, immune system is an umlsterm, head is an umlsterm, neck is an umlsterm, symptoms is an umlsterm, fever is an umlsterm, urticarial rashes is an umlsterm, lymphadenitis is an umlsterm, bacterial infections is an umlsterm, skin is an umlsterm, Diagnosis is an umlsterm, IgE is an umlsterm, concentrations is an umlsterm, signs is an umlsterm, allergy is an umlsterm, parasitic disease is an umlsterm, old is an umlsterm, woman is an umlsterm, hyper IgE syndrome is an umlsterm, treatment is an umlsterm, hyperplasia is an umlsterm, tongue is an umlsterm, symptoms is an umlsterm, hyper IgE syndrome is an umlsterm, intravenous immunoglobulin is an umlsterm, therapy is an umlsterm, IVIG is an umlsterm, single is an umlsterm, therapy is an umlsterm, symptoms is an umlsterm, knowledge is an umlsterm, therapeutic is an umlsterm, hyper IgE syndrome is an umlsterm, IVIG is an umlsterm, choices is an umlsterm, treatment is an umlsterm, hyper IgE syndrome is an umlsterm
HNO.90471063.eng.abstr_task0
Sentence: Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome .
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[ "umlsterm" ]
Hyperimmunoglobulin E syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, disorder is an umlsterm, immune system is an umlsterm, head is an umlsterm, neck is an umlsterm, symptoms is an umlsterm, fever is an umlsterm, urticarial rashes is an umlsterm, lymphadenitis is an umlsterm, bacterial infections is an umlsterm, skin is an umlsterm, Diagnosis is an umlsterm, IgE is an umlsterm, concentrations is an umlsterm, signs is an umlsterm, allergy is an umlsterm, parasitic disease is an umlsterm, old is an umlsterm, woman is an umlsterm, hyper IgE syndrome is an umlsterm, treatment is an umlsterm, hyperplasia is an umlsterm, tongue is an umlsterm, symptoms is an umlsterm, hyper IgE syndrome is an umlsterm, intravenous immunoglobulin is an umlsterm, therapy is an umlsterm, IVIG is an umlsterm, single is an umlsterm, therapy is an umlsterm, symptoms is an umlsterm, knowledge is an umlsterm, therapeutic is an umlsterm, hyper IgE syndrome is an umlsterm, IVIG is an umlsterm, choices is an umlsterm, treatment is an umlsterm, hyper IgE syndrome is an umlsterm
HNO.90471063.eng.abstr_task1
Sentence: Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome . Instructions: please typing these entity words according to sentence: Hyperimmunoglobulin E syndrome, syndrome, syndrome, disorder, immune system, head, neck, symptoms, fever, urticarial rashes, lymphadenitis, bacterial infections, skin, Diagnosis, IgE, concentrations, signs, allergy, parasitic disease, old, woman, hyper IgE syndrome, treatment, hyperplasia, tongue, symptoms, hyper IgE syndrome, intravenous immunoglobulin, therapy, IVIG, single, therapy, symptoms, knowledge, therapeutic, hyper IgE syndrome, IVIG, choices, treatment, hyper IgE syndrome Options: umlsterm
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Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome .
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[ "umlsterm" ]
Hyperimmunoglobulin E syndrome, syndrome, syndrome, disorder, immune system, head, neck, symptoms, fever, urticarial rashes, lymphadenitis, bacterial infections, skin, Diagnosis, IgE, concentrations, signs, allergy, parasitic disease, old, woman, hyper IgE syndrome, treatment, hyperplasia, tongue, symptoms, hyper IgE syndrome, intravenous immunoglobulin, therapy, IVIG, single, therapy, symptoms, knowledge, therapeutic, hyper IgE syndrome, IVIG, choices, treatment, hyper IgE syndrome
HNO.90471063.eng.abstr_task2
Sentence: Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome . Instructions: please extract entity words from the input sentence
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Hyperimmunoglobulin E syndrome ( Hiob syndrome or Buckley syndrome ) is a rare disorder of the immune system that can show characteristic manifestations in the head and neck . Typical symptoms are fever , recurrent urticarial rashes , lymphadenitis , and bacterial infections of the skin and various parenchymatous organs . Diagnosis is established by elevated serum IgE concentrations with the absence of any signs of allergy or parasitic disease . We present our clinical experiences in managing of a 29-year old woman whose hyper IgE syndrome was diagnosed initially during of the treatment of lymphatic hyperplasia of the base of the tongue although she had typical symptoms of hyper IgE syndrome for some years . High-dose intravenous immunoglobulin therapy ( IVIG ) was found to be well-tolerated and effective . More than one year after a single course of immunoglobin therapy symptoms markedly improved . Current knowledge and therapeutic options in hyper IgE syndrome are discussed . We recommend that IVIG be considered as one of the first choices in the treatment of hyper IgE syndrome .
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[ "umlsterm" ]
Objectives is an umlsterm, use is an umlsterm, opioids is an umlsterm, cancer is an umlsterm, cancer is an umlsterm, pain is an umlsterm, opioid is an umlsterm, therapy is an umlsterm, psychomotor performance is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, attention is an umlsterm, reaction time is an umlsterm, cancer is an umlsterm, pain is an umlsterm, pain is an umlsterm
DerAnaesthesist.90480613.eng.abstr_task0
Sentence: Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain .
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[ "umlsterm" ]
Objectives is an umlsterm, use is an umlsterm, opioids is an umlsterm, cancer is an umlsterm, cancer is an umlsterm, pain is an umlsterm, opioid is an umlsterm, therapy is an umlsterm, psychomotor performance is an umlsterm, opioid is an umlsterm, analgesia is an umlsterm, attention is an umlsterm, reaction time is an umlsterm, cancer is an umlsterm, pain is an umlsterm, pain is an umlsterm
DerAnaesthesist.90480613.eng.abstr_task1
Sentence: Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain . Instructions: please typing these entity words according to sentence: Objectives, use, opioids, cancer, cancer, pain, opioid, therapy, psychomotor performance, opioid, analgesia, attention, reaction time, cancer, pain, pain Options: umlsterm
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Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain .
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[ "umlsterm" ]
Objectives, use, opioids, cancer, cancer, pain, opioid, therapy, psychomotor performance, opioid, analgesia, attention, reaction time, cancer, pain, pain
DerAnaesthesist.90480613.eng.abstr_task2
Sentence: Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain . Instructions: please extract entity words from the input sentence
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Objectives : Despite increasing use of oral opioids in cancer and non cancer pain , little is known about the effects of long-term opioid therapy on psychomotor performance . This study was designed to investigate the effects of long-term opioid analgesia on attention and reaction time in cancer pain and in non-malignant pain .
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[ "umlsterm" ]
IL-2 is a Protein, IL-2 is a Protein, c - myc is a Protein, bcl-2 is a Protein, I kappa B - alpha is a Protein, I kappa B - beta is a Protein, CD40 is a Protein
10358154_task0
Sentence: New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.
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[ "Protein" ]
IL-2 is a Protein, IL-2 is a Protein, c - myc is a Protein, bcl-2 is a Protein, I kappa B - alpha is a Protein, I kappa B - beta is a Protein, CD40 is a Protein
10358154_task1
Sentence: New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin. Instructions: please typing these entity words according to sentence: IL-2, IL-2, c - myc, bcl-2, I kappa B - alpha, I kappa B - beta, CD40 Options: Protein
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New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.
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[ "Protein" ]
IL-2, IL-2, c - myc, bcl-2, I kappa B - alpha, I kappa B - beta, CD40
10358154_task2
Sentence: New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin. Instructions: please extract entity words from the input sentence
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New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice. We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation. In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation. We have investigated several molecular pathways that are known to be activated by IL-2 in T cells. We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction. On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors. PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta. PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes. We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.
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[ "Protein" ]
HIV-1 envelope glycoproteins is a protein_family_or_group, protein-1 is a protein_molecule, CD4 + T cells is a cell_type
103780_task0
Sentence: HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, protein_molecule
[ "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "B-protein_molecule", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038]
[ "HIV-1", "envelope", "glycoproteins", "induce", "activation", "of", "activated", "protein-1", "in", "CD4", "+", "T", "cells", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1995", "Dec", "1;270(48):29038", "]" ]
[ "protein_molecule", "other_name", "cell_component", "protein_family_or_group", "virus", "protein_complex", "cell_line", "other_organic_compound", "cell_type", "multi_cell", "DNA_domain_or_region" ]
HIV-1 envelope glycoproteins is a protein_family_or_group, protein-1 is a protein_molecule, CD4 + T cells is a cell_type
103780_task1
Sentence: HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] Instructions: please typing these entity words according to sentence: HIV-1 envelope glycoproteins, protein-1, CD4 + T cells Options: cell_type, protein_family_or_group, protein_molecule
[ "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "B-protein_molecule", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038]
[ "HIV-1", "envelope", "glycoproteins", "induce", "activation", "of", "activated", "protein-1", "in", "CD4", "+", "T", "cells", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1995", "Dec", "1;270(48):29038", "]" ]
[ "protein_molecule", "other_name", "cell_component", "protein_family_or_group", "virus", "protein_complex", "cell_line", "other_organic_compound", "cell_type", "multi_cell", "DNA_domain_or_region" ]
HIV-1 envelope glycoproteins, protein-1, CD4 + T cells
103780_task2
Sentence: HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] Instructions: please extract entity words from the input sentence
[ "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O", "O", "O", "O", "B-protein_molecule", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038]
[ "HIV-1", "envelope", "glycoproteins", "induce", "activation", "of", "activated", "protein-1", "in", "CD4", "+", "T", "cells", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1995", "Dec", "1;270(48):29038", "]" ]
[ "protein_molecule", "other_name", "cell_component", "protein_family_or_group", "virus", "protein_complex", "cell_line", "other_organic_compound", "cell_type", "multi_cell", "DNA_domain_or_region" ]
intra - abdominal abscesses is an umlsterm, operative procedures is an umlsterm, anatomy is an umlsterm, intra - abdominal abscesses is an umlsterm, abscesses is an umlsterm, anterior is an umlsterm, retroperitoneal space is an umlsterm, ultrasonography is an umlsterm, method is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, ultrasound is an umlsterm, drainage is an umlsterm, therapy is an umlsterm, morbidity is an umlsterm, criteria is an umlsterm, abscesses is an umlsterm, disease is an umlsterm, surgical is an umlsterm, liver abscesses is an umlsterm, abscesses is an umlsterm, pancreas is an umlsterm, spleen is an umlsterm, disease is an umlsterm, surgery is an umlsterm, antibiotic drug is an umlsterm, therapy is an umlsterm, infectious diseases is an umlsterm, tuberculosis is an umlsterm, actinomycosis is an umlsterm, amebiasis is an umlsterm, patho - anatomical is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm, infection is an umlsterm
DerChirurg.80690813.eng.abstr_task0
Sentence: In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration .
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[ "umlsterm" ]
intra - abdominal abscesses is an umlsterm, operative procedures is an umlsterm, anatomy is an umlsterm, intra - abdominal abscesses is an umlsterm, abscesses is an umlsterm, anterior is an umlsterm, retroperitoneal space is an umlsterm, ultrasonography is an umlsterm, method is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, ultrasound is an umlsterm, drainage is an umlsterm, therapy is an umlsterm, morbidity is an umlsterm, criteria is an umlsterm, abscesses is an umlsterm, disease is an umlsterm, surgical is an umlsterm, liver abscesses is an umlsterm, abscesses is an umlsterm, pancreas is an umlsterm, spleen is an umlsterm, disease is an umlsterm, surgery is an umlsterm, antibiotic drug is an umlsterm, therapy is an umlsterm, infectious diseases is an umlsterm, tuberculosis is an umlsterm, actinomycosis is an umlsterm, amebiasis is an umlsterm, patho - anatomical is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm, infection is an umlsterm
DerChirurg.80690813.eng.abstr_task1
Sentence: In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration . Instructions: please typing these entity words according to sentence: intra - abdominal abscesses, operative procedures, anatomy, intra - abdominal abscesses, abscesses, anterior, retroperitoneal space, ultrasonography, method, diagnosis, therapy, ultrasound, drainage, therapy, morbidity, criteria, abscesses, disease, surgical, liver abscesses, abscesses, pancreas, spleen, disease, surgery, antibiotic drug, therapy, infectious diseases, tuberculosis, actinomycosis, amebiasis, patho - anatomical, diagnostic, therapeutic, infection Options: umlsterm
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In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration .
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[ "umlsterm" ]
intra - abdominal abscesses, operative procedures, anatomy, intra - abdominal abscesses, abscesses, anterior, retroperitoneal space, ultrasonography, method, diagnosis, therapy, ultrasound, drainage, therapy, morbidity, criteria, abscesses, disease, surgical, liver abscesses, abscesses, pancreas, spleen, disease, surgery, antibiotic drug, therapy, infectious diseases, tuberculosis, actinomycosis, amebiasis, patho - anatomical, diagnostic, therapeutic, infection
DerChirurg.80690813.eng.abstr_task2
Sentence: In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration . Instructions: please extract entity words from the input sentence
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In more than 80 % of cases , intra-abdominal abscesses derive from an intra-abdominal organ , and in most cases they develop after operative procedures . Regarding anatomy , intra-abdominal abscesses can be devided into intra-peritoneal and visceral abscesses and those located in the anterior retroperitoneal space . Despite improvements in ultrasonography , CT is still the most effective method in diagnosis and therapy . Percutaneous ultrasound or CT-guided drainage is a therapy characterized by low procedural morbidity and is successful in 80 % of cases if strict criteria are met . Complicated abscesses and those cases in which the underlying disease has to be treated require surgical intervention . Most liver abscesses are treated interventionally ; in abscesses of the pancreas or spleen and in Crohn's disease , surgery is necessary . The combination with sufficient antibiotic drug therapy is very important . Specific infectious diseases appearing as intra-abdominal conglomerates ( tuberculosis , actinomycosis , amebiasis ) lead to a delay in diagnostics because of their scarcity and are characterized by special patho-anatomical , diagnostic and therapeutic features . The crucial thing is to take a specific infection into consideration .
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[ "umlsterm" ]
herz- is an umlsterm, thoraxchirurgischer is an umlsterm, Patienten is an umlsterm, Differentialdiagnosen is an umlsterm, Patienten is an umlsterm, Zusatzdiagnostik is an umlsterm, Thoraxbettaufnahme is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.00140170.ger.abstr_task0
Sentence: Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden .
[ "Pulmonale", "Verschattungen", "stellen", "einen", "der", "haeufigsten", "Roentgenbefunde", "herz-", "und", "thoraxchirurgischer", "Patienten", "dar", ".", "Anhand", "zweier", "Beispiele", "werden", "die", "wichtigsten", "Differentialdiagnosen", "dieses", "Befundes", "illustriert", ".", "Auch", "ohne", "eine", "weitergehende", "Abklaerung", "durch", "Aufnahmen", "nach", "Umlagerung", "des", "Patienten", ",", "sonographische", "oder", "computertomographische", "Zusatzdiagnostik", "kann", "bereits", "anhand", "der", "Thoraxbettaufnahme", "in", "den", "meisten", "Faellen", "eine", "aetiologische", "Zuordnung", "stattfinden", "." ]
[ "umlsterm" ]
herz- is an umlsterm, thoraxchirurgischer is an umlsterm, Patienten is an umlsterm, Differentialdiagnosen is an umlsterm, Patienten is an umlsterm, Zusatzdiagnostik is an umlsterm, Thoraxbettaufnahme is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.00140170.ger.abstr_task1
Sentence: Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden . Instructions: please typing these entity words according to sentence: herz-, thoraxchirurgischer, Patienten, Differentialdiagnosen, Patienten, Zusatzdiagnostik, Thoraxbettaufnahme Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden .
[ "Pulmonale", "Verschattungen", "stellen", "einen", "der", "haeufigsten", "Roentgenbefunde", "herz-", "und", "thoraxchirurgischer", "Patienten", "dar", ".", "Anhand", "zweier", "Beispiele", "werden", "die", "wichtigsten", "Differentialdiagnosen", "dieses", "Befundes", "illustriert", ".", "Auch", "ohne", "eine", "weitergehende", "Abklaerung", "durch", "Aufnahmen", "nach", "Umlagerung", "des", "Patienten", ",", "sonographische", "oder", "computertomographische", "Zusatzdiagnostik", "kann", "bereits", "anhand", "der", "Thoraxbettaufnahme", "in", "den", "meisten", "Faellen", "eine", "aetiologische", "Zuordnung", "stattfinden", "." ]
[ "umlsterm" ]
herz-, thoraxchirurgischer, Patienten, Differentialdiagnosen, Patienten, Zusatzdiagnostik, Thoraxbettaufnahme
ZfuerHerzThoraxGefaesschirurgie.00140170.ger.abstr_task2
Sentence: Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Pulmonale Verschattungen stellen einen der haeufigsten Roentgenbefunde herz- und thoraxchirurgischer Patienten dar . Anhand zweier Beispiele werden die wichtigsten Differentialdiagnosen dieses Befundes illustriert . Auch ohne eine weitergehende Abklaerung durch Aufnahmen nach Umlagerung des Patienten , sonographische oder computertomographische Zusatzdiagnostik kann bereits anhand der Thoraxbettaufnahme in den meisten Faellen eine aetiologische Zuordnung stattfinden .
[ "Pulmonale", "Verschattungen", "stellen", "einen", "der", "haeufigsten", "Roentgenbefunde", "herz-", "und", "thoraxchirurgischer", "Patienten", "dar", ".", "Anhand", "zweier", "Beispiele", "werden", "die", "wichtigsten", "Differentialdiagnosen", "dieses", "Befundes", "illustriert", ".", "Auch", "ohne", "eine", "weitergehende", "Abklaerung", "durch", "Aufnahmen", "nach", "Umlagerung", "des", "Patienten", ",", "sonographische", "oder", "computertomographische", "Zusatzdiagnostik", "kann", "bereits", "anhand", "der", "Thoraxbettaufnahme", "in", "den", "meisten", "Faellen", "eine", "aetiologische", "Zuordnung", "stattfinden", "." ]
[ "umlsterm" ]