bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags sequence	text stringlengths 5 72.4k	tokens sequence	types sequence
femoral nerves is an umlsterm, invasive procedures is an umlsterm, knee is an umlsterm, ankle joint is an umlsterm, flexibility is an umlsterm, anaesthetist 's is an umlsterm, schedule is an umlsterm, relaxation is an umlsterm, muscles is an umlsterm, contraindications is an umlsterm, arrhythmia is an umlsterm, heart is an umlsterm, lidocaine is an umlsterm, mepivacaine is an umlsterm, sciatic nerve is an umlsterm, femoral nerve is an umlsterm, book is an umlsterm, patient is an umlsterm, complications is an umlsterm, operation is an umlsterm, pain is an umlsterm	Arthroskopie.80110102.eng.abstr_task1	Sentence: Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty . Instructions: please typing these entity words according to sentence: femoral nerves, invasive procedures, knee, ankle joint, flexibility, anaesthetist 's, schedule, relaxation, muscles, contraindications, arrhythmia, heart, lidocaine, mepivacaine, sciatic nerve, femoral nerve, book, patient, complications, operation, pain Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty .	[ "Block", "of", "the", "sciatic", "and", "femoral", "nerves", "can", "be", "performed", "either", "by", "the", "surgeon", "or", "by", "the", "anaesthetist", ",", "allowing", "for", "numerous", "minimally", "invasive", "procedures", "in", "the", "knee", "and", "ankle", "joint", ".", "It", "also", "offers", "a", "certain", "flexibility", "with", "regard", "to", "the", "anaesthetist", "'s", "schedule", "and", "provides", "a", "good", "and", "long", "anaesthesia", "and", "relaxation", "of", "the", "quadricep", "and", "hamstring", "muscles", ".", "Some", "contraindications", "-", "arrhythmia", ",", "severe", "conduction", "disturbance", "and", "heart", "failure", "-", "should", "be", "considered", ",", "as", "well", "as", "vegetative", "lability", "and", "oversensitivity", "to", "xylocaine", ",", "lidocaine", "or", "mepivacaine", ".", "There", "is", "no", "difficulty", "in", "finding", "the", "sciatic", "nerve", "and", "the", "femoral", "nerve", "as", "the", "topography", "is", "well", "described", "by", "Daniel", "C.", "Moore", "in", "his", "book", "about", "regional", "block", ".", "Though", "easy", "to", "perform", ",", "and", "even", "when", "wished", "for", "by", "the", "patient", ",", "the", "surgeon", "has", "to", "be", "aware", "of", "possible", "complications", ".", "In", "some", "cases", "we", "recommend", "that", "an", "anaesthesiologist", "stand", "by", ".", "In", "only", "2", "of", "720", "cases", "did", "the", "operation", "have", "to", "be", "interrupted", "because", "of", "severe", "pain", "or", "unexpected", "difficulty", "." ]	[ "umlsterm" ]
femoral nerves, invasive procedures, knee, ankle joint, flexibility, anaesthetist 's, schedule, relaxation, muscles, contraindications, arrhythmia, heart, lidocaine, mepivacaine, sciatic nerve, femoral nerve, book, patient, complications, operation, pain	Arthroskopie.80110102.eng.abstr_task2	Sentence: Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty .	[ "Block", "of", "the", "sciatic", "and", "femoral", "nerves", "can", "be", "performed", "either", "by", "the", "surgeon", "or", "by", "the", "anaesthetist", ",", "allowing", "for", "numerous", "minimally", "invasive", "procedures", "in", "the", "knee", "and", "ankle", "joint", ".", "It", "also", "offers", "a", "certain", "flexibility", "with", "regard", "to", "the", "anaesthetist", "'s", "schedule", "and", "provides", "a", "good", "and", "long", "anaesthesia", "and", "relaxation", "of", "the", "quadricep", "and", "hamstring", "muscles", ".", "Some", "contraindications", "-", "arrhythmia", ",", "severe", "conduction", "disturbance", "and", "heart", "failure", "-", "should", "be", "considered", ",", "as", "well", "as", "vegetative", "lability", "and", "oversensitivity", "to", "xylocaine", ",", "lidocaine", "or", "mepivacaine", ".", "There", "is", "no", "difficulty", "in", "finding", "the", "sciatic", "nerve", "and", "the", "femoral", "nerve", "as", "the", "topography", "is", "well", "described", "by", "Daniel", "C.", "Moore", "in", "his", "book", "about", "regional", "block", ".", "Though", "easy", "to", "perform", ",", "and", "even", "when", "wished", "for", "by", "the", "patient", ",", "the", "surgeon", "has", "to", "be", "aware", "of", "possible", "complications", ".", "In", "some", "cases", "we", "recommend", "that", "an", "anaesthesiologist", "stand", "by", ".", "In", "only", "2", "of", "720", "cases", "did", "the", "operation", "have", "to", "be", "interrupted", "because", "of", "severe", "pain", "or", "unexpected", "difficulty", "." ]	[ "umlsterm" ]
wachsende is an umlsterm, gezielt is an umlsterm, Elementen is an umlsterm	Psychotherapeut.60410088.ger.abstr_task0	Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .	[ "Es", "wird", "der", "Versuch", "unternommen", ",", "dass", "klassische", "Konzept", "der", "Konversion", "unter", "Einbeziehung", "psychodynamischer", "Auffassungen", "zu", "operationalisieren", ".", "Im", "Hintergrund", "steht", "die", "wachsende", "Evidenz", ",", "dass", "Konversionsvorgaenge", "ueber", "die", "hysterische", "Psychodynamik", "weit", "hinausreichen", ".", "Der", "Operationalisierungsentwurf", "ist", "restriktiv", "entworfen", ",", "um", "gezielt", "die", "profuse", "Ausweitung", "und", "damit", "Entwertung", "des", "Konzepts", "zu", "verhindern", ".", "Der", "Operationalisierungsvorgang", "wird", "in", "drei", "Schritten", "nachvollziehbar", "gemacht", ".", "Ausgehend", "von", "einer", "Konsensusdefinition", "wird", "ueber", "die", "Darstellung", "von", "11", "dynamischen", "Elementen", "des", "Konversionskonstrukts", "versucht", ",", "seine", "Komplexitaet", "herabzusetzen", ",", "um", "dann", "in", "die", "eigentliche", "Operationalisierung", "ueberzuleiten", "." ]	[ "umlsterm" ]
wachsende is an umlsterm, gezielt is an umlsterm, Elementen is an umlsterm	Psychotherapeut.60410088.ger.abstr_task1	Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please typing these entity words according to sentence: wachsende, gezielt, Elementen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .	[ "Es", "wird", "der", "Versuch", "unternommen", ",", "dass", "klassische", "Konzept", "der", "Konversion", "unter", "Einbeziehung", "psychodynamischer", "Auffassungen", "zu", "operationalisieren", ".", "Im", "Hintergrund", "steht", "die", "wachsende", "Evidenz", ",", "dass", "Konversionsvorgaenge", "ueber", "die", "hysterische", "Psychodynamik", "weit", "hinausreichen", ".", "Der", "Operationalisierungsentwurf", "ist", "restriktiv", "entworfen", ",", "um", "gezielt", "die", "profuse", "Ausweitung", "und", "damit", "Entwertung", "des", "Konzepts", "zu", "verhindern", ".", "Der", "Operationalisierungsvorgang", "wird", "in", "drei", "Schritten", "nachvollziehbar", "gemacht", ".", "Ausgehend", "von", "einer", "Konsensusdefinition", "wird", "ueber", "die", "Darstellung", "von", "11", "dynamischen", "Elementen", "des", "Konversionskonstrukts", "versucht", ",", "seine", "Komplexitaet", "herabzusetzen", ",", "um", "dann", "in", "die", "eigentliche", "Operationalisierung", "ueberzuleiten", "." ]	[ "umlsterm" ]
wachsende, gezielt, Elementen	Psychotherapeut.60410088.ger.abstr_task2	Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .	[ "Es", "wird", "der", "Versuch", "unternommen", ",", "dass", "klassische", "Konzept", "der", "Konversion", "unter", "Einbeziehung", "psychodynamischer", "Auffassungen", "zu", "operationalisieren", ".", "Im", "Hintergrund", "steht", "die", "wachsende", "Evidenz", ",", "dass", "Konversionsvorgaenge", "ueber", "die", "hysterische", "Psychodynamik", "weit", "hinausreichen", ".", "Der", "Operationalisierungsentwurf", "ist", "restriktiv", "entworfen", ",", "um", "gezielt", "die", "profuse", "Ausweitung", "und", "damit", "Entwertung", "des", "Konzepts", "zu", "verhindern", ".", "Der", "Operationalisierungsvorgang", "wird", "in", "drei", "Schritten", "nachvollziehbar", "gemacht", ".", "Ausgehend", "von", "einer", "Konsensusdefinition", "wird", "ueber", "die", "Darstellung", "von", "11", "dynamischen", "Elementen", "des", "Konversionskonstrukts", "versucht", ",", "seine", "Komplexitaet", "herabzusetzen", ",", "um", "dann", "in", "die", "eigentliche", "Operationalisierung", "ueberzuleiten", "." ]	[ "umlsterm" ]
MHC class II expression is an other_name, human class II trans - activator constructs is a DNA_family_or_group, N - terminal domain is a protein_domain_or_region	56366_task0	Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, protein_domain_or_region, other_name	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.	[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]	[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]
MHC class II expression is an other_name, human class II trans - activator constructs is a DNA_family_or_group, N - terminal domain is a protein_domain_or_region	56366_task1	Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please typing these entity words according to sentence: MHC class II expression, human class II trans - activator constructs, N - terminal domain Options: DNA_family_or_group, protein_domain_or_region, other_name	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.	[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]	[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]
MHC class II expression, human class II trans - activator constructs, N - terminal domain	56366_task2	Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]	Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.	[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]	[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]
JunB is a Protein, FosB is a Protein, c - Fos is a Protein, immunoglobulin - like transcript-2 is a Protein, leukocyte Ig - like receptor 1 is a Protein, HLA - B27 is a Protein, JunB is a Protein, FosB is a Protein, c - Fos is a Protein	10201929_task0	Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.	[ "Engagement", "of", "natural", "cytotoxicity", "programs", "regulates", "AP-1", "expression", "in", "the", "NKL", "human", "NK", "cell", "line", ".", "\n", "NK", "cell", "cytotoxicity", "is", "a", "fast", "and", "efficient", "mechanism", "of", "target", "cell", "lysis", ".", "Using", "transcription", "analysis", ",", "such", "as", "multiplex", "messenger", "assays", ",", "we", "show", "here", "that", "natural", "cytotoxicity", "exerted", "by", "the", "human", "NKL", "cell", "line", "correlates", "with", "mRNA", "accumulation", "of", "very", "early", "activator", "protein", "(", "AP)-1", "transcription", "factor", "genes", "such", "as", "JunB", ",", "FosB", "and", "c", "-", "Fos", ".", "In", "addition", ",", "DNA", "-", "binding", "activities", "of", "Jun", "-", "Fos", "heterodimers", "were", "observed", "by", "electrophoretic", "mobility", "shift", "assays", "during", "the", "course", "of", "natural", "cytotoxicity", ".", "Interaction", "between", "immunoglobulin", "-", "like", "transcript-2", "/", "leukocyte", "Ig", "-", "like", "receptor", "1", "on", "NKL", "cells", "and", "HLA", "-", "B27", "on", "target", "cells", "leads", "to", "an", "impairment", "of", "NKL", "natural", "cytotoxicity", ",", "which", "correlates", "with", "an", "absence", "of", "JunB", ",", "FosB", ",", "and", "c", "-", "Fos", "transcription", ",", "as", "well", "as", "an", "absence", "of", "their", "DNA", "-", "binding", "activity", ".", "Our", "studies", "thus", "indicate", "that", ",", "despite", "the", "rapidity", "of", "NK", "cell", "-", "mediated", "lysis", ",", "AP-1", "transcription", "factor", "is", "activated", "during", "the", "early", "stage", "of", "NK", "cell", "cytolytic", "programs", "and", "that", "engagement", "of", "NK", "cell", "inhibitory", "receptors", "for", "MHC", "class", "I", "molecules", "impairs", "the", "very", "early", "activation", "of", "AP-1", "." ]	[ "Protein" ]
JunB is a Protein, FosB is a Protein, c - Fos is a Protein, immunoglobulin - like transcript-2 is a Protein, leukocyte Ig - like receptor 1 is a Protein, HLA - B27 is a Protein, JunB is a Protein, FosB is a Protein, c - Fos is a Protein	10201929_task1	Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please typing these entity words according to sentence: JunB, FosB, c - Fos, immunoglobulin - like transcript-2, leukocyte Ig - like receptor 1, HLA - B27, JunB, FosB, c - Fos Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.	[ "Engagement", "of", "natural", "cytotoxicity", "programs", "regulates", "AP-1", "expression", "in", "the", "NKL", "human", "NK", "cell", "line", ".", "\n", "NK", "cell", "cytotoxicity", "is", "a", "fast", "and", "efficient", "mechanism", "of", "target", "cell", "lysis", ".", "Using", "transcription", "analysis", ",", "such", "as", "multiplex", "messenger", "assays", ",", "we", "show", "here", "that", "natural", "cytotoxicity", "exerted", "by", "the", "human", "NKL", "cell", "line", "correlates", "with", "mRNA", "accumulation", "of", "very", "early", "activator", "protein", "(", "AP)-1", "transcription", "factor", "genes", "such", "as", "JunB", ",", "FosB", "and", "c", "-", "Fos", ".", "In", "addition", ",", "DNA", "-", "binding", "activities", "of", "Jun", "-", "Fos", "heterodimers", "were", "observed", "by", "electrophoretic", "mobility", "shift", "assays", "during", "the", "course", "of", "natural", "cytotoxicity", ".", "Interaction", "between", "immunoglobulin", "-", "like", "transcript-2", "/", "leukocyte", "Ig", "-", "like", "receptor", "1", "on", "NKL", "cells", "and", "HLA", "-", "B27", "on", "target", "cells", "leads", "to", "an", "impairment", "of", "NKL", "natural", "cytotoxicity", ",", "which", "correlates", "with", "an", "absence", "of", "JunB", ",", "FosB", ",", "and", "c", "-", "Fos", "transcription", ",", "as", "well", "as", "an", "absence", "of", "their", "DNA", "-", "binding", "activity", ".", "Our", "studies", "thus", "indicate", "that", ",", "despite", "the", "rapidity", "of", "NK", "cell", "-", "mediated", "lysis", ",", "AP-1", "transcription", "factor", "is", "activated", "during", "the", "early", "stage", "of", "NK", "cell", "cytolytic", "programs", "and", "that", "engagement", "of", "NK", "cell", "inhibitory", "receptors", "for", "MHC", "class", "I", "molecules", "impairs", "the", "very", "early", "activation", "of", "AP-1", "." ]	[ "Protein" ]
JunB, FosB, c - Fos, immunoglobulin - like transcript-2, leukocyte Ig - like receptor 1, HLA - B27, JunB, FosB, c - Fos	10201929_task2	Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.	[ "Engagement", "of", "natural", "cytotoxicity", "programs", "regulates", "AP-1", "expression", "in", "the", "NKL", "human", "NK", "cell", "line", ".", "\n", "NK", "cell", "cytotoxicity", "is", "a", "fast", "and", "efficient", "mechanism", "of", "target", "cell", "lysis", ".", "Using", "transcription", "analysis", ",", "such", "as", "multiplex", "messenger", "assays", ",", "we", "show", "here", "that", "natural", "cytotoxicity", "exerted", "by", "the", "human", "NKL", "cell", "line", "correlates", "with", "mRNA", "accumulation", "of", "very", "early", "activator", "protein", "(", "AP)-1", "transcription", "factor", "genes", "such", "as", "JunB", ",", "FosB", "and", "c", "-", "Fos", ".", "In", "addition", ",", "DNA", "-", "binding", "activities", "of", "Jun", "-", "Fos", "heterodimers", "were", "observed", "by", "electrophoretic", "mobility", "shift", "assays", "during", "the", "course", "of", "natural", "cytotoxicity", ".", "Interaction", "between", "immunoglobulin", "-", "like", "transcript-2", "/", "leukocyte", "Ig", "-", "like", "receptor", "1", "on", "NKL", "cells", "and", "HLA", "-", "B27", "on", "target", "cells", "leads", "to", "an", "impairment", "of", "NKL", "natural", "cytotoxicity", ",", "which", "correlates", "with", "an", "absence", "of", "JunB", ",", "FosB", ",", "and", "c", "-", "Fos", "transcription", ",", "as", "well", "as", "an", "absence", "of", "their", "DNA", "-", "binding", "activity", ".", "Our", "studies", "thus", "indicate", "that", ",", "despite", "the", "rapidity", "of", "NK", "cell", "-", "mediated", "lysis", ",", "AP-1", "transcription", "factor", "is", "activated", "during", "the", "early", "stage", "of", "NK", "cell", "cytolytic", "programs", "and", "that", "engagement", "of", "NK", "cell", "inhibitory", "receptors", "for", "MHC", "class", "I", "molecules", "impairs", "the", "very", "early", "activation", "of", "AP-1", "." ]	[ "Protein" ]
singleton pregnancy is a Condition, cesarean section is a Procedure, after 37 weeks is a Value, gestation is a Measurement	NCT02277041_inc_task0	Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Procedure, Measurement, Value	[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]	Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.	[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]	[ "Condition", "Procedure", "Value", "Measurement" ]
singleton pregnancy is a Condition, cesarean section is a Procedure, after 37 weeks is a Value, gestation is a Measurement	NCT02277041_inc_task1	Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please typing these entity words according to sentence: singleton pregnancy, cesarean section, after 37 weeks, gestation Options: Condition, Procedure, Measurement, Value	[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]	Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.	[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]	[ "Condition", "Procedure", "Value", "Measurement" ]
singleton pregnancy, cesarean section, after 37 weeks, gestation	NCT02277041_inc_task2	Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]	Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.	[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]	[ "Condition", "Procedure", "Value", "Measurement" ]
Synaptotagmin I is a protein, polymerized tubulin is a protein	1.0alpha7.train.823_task0	Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein	[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]	Synaptotagmin I also binds to polymerized tubulin.	[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]	[ "protein", "protein-family" ]
Synaptotagmin I is a protein, polymerized tubulin is a protein	1.0alpha7.train.823_task1	Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please typing these entity words according to sentence: Synaptotagmin I, polymerized tubulin Options: protein	[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]	Synaptotagmin I also binds to polymerized tubulin.	[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]	[ "protein", "protein-family" ]
Synaptotagmin I, polymerized tubulin	1.0alpha7.train.823_task2	Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please extract entity words from the input sentence	[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]	Synaptotagmin I also binds to polymerized tubulin.	[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]	[ "protein", "protein-family" ]
CYP2E1 is a GENE-Y, CYP2B4 is a GENE-Y, NADPH - cytochrome P450 reductase is a GENE-Y	23043184_task0	Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]	Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.	[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
CYP2E1 is a GENE-Y, CYP2B4 is a GENE-Y, NADPH - cytochrome P450 reductase is a GENE-Y	23043184_task1	Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please typing these entity words according to sentence: CYP2E1, CYP2B4, NADPH - cytochrome P450 reductase Options: GENE-Y	[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]	Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.	[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
CYP2E1, CYP2B4, NADPH - cytochrome P450 reductase	23043184_task2	Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]	Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.	[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole is a CHEMICAL, A-381393 is a CHEMICAL, dopamine D4 receptor is a GENE-Y	15992586_task0	Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]	2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.	[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole is a CHEMICAL, A-381393 is a CHEMICAL, dopamine D4 receptor is a GENE-Y	15992586_task1	Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please typing these entity words according to sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole, A-381393, dopamine D4 receptor Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]	2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.	[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole, A-381393, dopamine D4 receptor	15992586_task2	Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]	2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.	[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
visceral fat gain is a Outcome_Physical, endothelial dysfunction is a Outcome_Physical, endothelial function is a Outcome_Physical, Endothelial dysfunction is a Outcome_Physical, gain weight is a Intervention_Physical, maintain weight is a Intervention_Control, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ) is a Outcome_Physical, total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography is a Outcome_Physical, subcutaneous fat gain is a Outcome_Physical, blood pressure is a Outcome_Physical	47051_task0	Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Intervention_Control	[ "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .	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visceral fat gain is a Outcome_Physical, endothelial dysfunction is a Outcome_Physical, endothelial function is a Outcome_Physical, Endothelial dysfunction is a Outcome_Physical, gain weight is a Intervention_Physical, maintain weight is a Intervention_Control, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ) is a Outcome_Physical, total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography is a Outcome_Physical, subcutaneous fat gain is a Outcome_Physical, blood pressure is a Outcome_Physical	47051_task1	Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . Instructions: please typing these entity words according to sentence: visceral fat gain, endothelial dysfunction, endothelial function, Endothelial dysfunction, gain weight, maintain weight, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ), total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography, subcutaneous fat gain, blood pressure Options: Intervention_Physical, Outcome_Physical, Intervention_Control	[ "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .	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visceral fat gain, endothelial dysfunction, endothelial function, Endothelial dysfunction, gain weight, maintain weight, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ), total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography, subcutaneous fat gain, blood pressure	47051_task2	Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . 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OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .	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Patient navigation is a Intervention_Educational, diagnostic resolution is a Outcome_Other, underserved population . is a Participant_Condition, low - income , uninsured , and minority populations . is a Participant_Condition, lay patient navigators is a Intervention_Educational, no - navigation ( control ) is a Intervention_Control, colorectal is a Outcome_Other, Time to resolution is a Outcome_Other, prostate screening resolution is a Outcome_Other, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . is a Participant_Condition	56785_task0	Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Outcome_Other, Intervention_Control, Participant_Condition	[ "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .	[ "Patient", "navigation", "improves", "cancer", "diagnostic", "resolution", ":", "an", "individually", "randomized", "clinical", "trial", "in", "an", "underserved", "population", ".", "BACKGROUND", "Barriers", "to", "timely", "resolution", "of", "abnormal", "cancer", "screening", "tests", "add", "to", "cancer", "health", "disparities", "among", "low", "-", "income", ",", "uninsured", ",", "and", "minority", "populations", ".", "We", "conducted", "a", "randomized", "trial", "to", "evaluate", "the", "impact", "of", "lay", "patient", "navigators", "on", "time", "to", "resolution", "and", "completion", "of", "follow", "-", "up", "testing", "among", "patients", "with", "abnormal", "screening", "tests", "in", "a", "medically", "underserved", "patient", "population", ".", "METHODS", "Denver", "Health", ",", "the", "safety", "-", "net", "health", "care", "system", "serving", "Denver", ",", "is", "one", "of", "10", "performance", "sites", "participating", "in", "the", "Patient", "Navigation", "Research", "Program", ".", "Of", "993", "eligible", "subjects", "with", "abnormal", "screening", "tests", "randomized", "to", "navigation", "and", "no", "-", "navigation", "(", "control", ")", "arms", "and", "analyzed", ",", "628", "had", "abnormal", "breast", "screens", "(", "66", "abnormal", "clinical", "breast", "examinations", ",", "304", "BIRADS", "0", ",", "200", "BIRADS", "3", ",", "58", "BIRADS", "4", "or", "5", ")", "whereas", "235", "had", "abnormal", "colorectal", "and", "130", "had", "abnormal", "prostate", "screens", ".", "RESULTS", "Time", "to", "resolution", "was", "significantly", "shorter", "in", "the", "navigated", "group", "(", "stratified", "log", "rank", "test", ",", "P", "<", "0.001", ")", ".", "Patient", "navigation", "improved", "diagnostic", "resolution", "for", "patients", "presenting", "with", "mammographic", "BIRADS", "3", "(", "P", "=", "0.0003", ")", "and", "BIRADS", "0", "(", "P", "=", "0.09", ")", ",", "but", "not", "BIRADS", "4/5", "or", "abnormal", "breast", "examinations", ".", "Navigation", "shortened", "the", "time", "for", "both", "colorectal", "(", "P", "=", "0.0017", ")", "and", "prostate", "screening", "resolution", "(", "P", "=", "0.06", ")", ".", "Participant", "demographics", "included", "72", "%", "minority", ",", "49", "%", "with", "annual", "household", "income", "less", "than", "$", "10,000", ",", "and", "36", "%", "uninsured", ".", "CONCLUSIONS", "Patient", "navigation", "positively", "impacts", "time", "to", "resolution", "of", "abnormal", "screening", "tests", "for", "breast", ",", "colorectal", ",", "and", "prostate", "cancers", "in", "a", "medically", "underserved", "population", ".", "IMPACT", "By", "shortening", "the", "time", "to", "and", "increasing", "the", "proportion", "of", "patients", "with", "diagnostic", "resolution", "patient", "navigation", "could", "reduce", "disparities", "in", "stage", "at", "diagnosis", "and", "improve", "cancer", "outcomes", "." ]	[ "Participant_Condition", "Outcome_Other", "Intervention_Control", "Intervention_Educational" ]
Patient navigation is a Intervention_Educational, diagnostic resolution is a Outcome_Other, underserved population . is a Participant_Condition, low - income , uninsured , and minority populations . is a Participant_Condition, lay patient navigators is a Intervention_Educational, no - navigation ( control ) is a Intervention_Control, colorectal is a Outcome_Other, Time to resolution is a Outcome_Other, prostate screening resolution is a Outcome_Other, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . is a Participant_Condition	56785_task1	Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please typing these entity words according to sentence: Patient navigation, diagnostic resolution, underserved population ., low - income , uninsured , and minority populations ., lay patient navigators, no - navigation ( control ), colorectal, Time to resolution, prostate screening resolution, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . Options: Intervention_Educational, Outcome_Other, Intervention_Control, Participant_Condition	[ "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .	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Patient navigation, diagnostic resolution, underserved population ., low - income , uninsured , and minority populations ., lay patient navigators, no - navigation ( control ), colorectal, Time to resolution, prostate screening resolution, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured .	56785_task2	Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .	[ "Patient", "navigation", "improves", "cancer", "diagnostic", "resolution", ":", "an", "individually", "randomized", "clinical", "trial", "in", "an", "underserved", "population", ".", "BACKGROUND", "Barriers", "to", "timely", "resolution", "of", "abnormal", "cancer", "screening", "tests", "add", "to", "cancer", "health", "disparities", "among", "low", "-", "income", ",", "uninsured", ",", "and", "minority", "populations", ".", "We", "conducted", "a", "randomized", "trial", "to", "evaluate", "the", "impact", "of", "lay", "patient", "navigators", "on", "time", "to", "resolution", "and", "completion", "of", "follow", "-", "up", "testing", "among", "patients", "with", "abnormal", "screening", "tests", "in", "a", "medically", "underserved", "patient", "population", ".", "METHODS", "Denver", "Health", ",", "the", "safety", "-", "net", "health", "care", "system", "serving", "Denver", ",", "is", "one", "of", "10", "performance", "sites", "participating", "in", "the", "Patient", "Navigation", "Research", "Program", ".", "Of", "993", "eligible", "subjects", "with", "abnormal", "screening", "tests", "randomized", "to", "navigation", "and", "no", "-", "navigation", "(", "control", ")", "arms", "and", "analyzed", ",", "628", "had", "abnormal", "breast", "screens", "(", "66", "abnormal", "clinical", "breast", "examinations", ",", "304", "BIRADS", "0", ",", "200", "BIRADS", "3", ",", "58", "BIRADS", "4", "or", "5", ")", "whereas", "235", "had", "abnormal", "colorectal", "and", "130", "had", "abnormal", "prostate", "screens", ".", "RESULTS", "Time", "to", "resolution", "was", "significantly", "shorter", "in", "the", "navigated", "group", "(", "stratified", "log", "rank", "test", ",", "P", "<", "0.001", ")", ".", "Patient", "navigation", "improved", "diagnostic", "resolution", "for", "patients", "presenting", "with", "mammographic", "BIRADS", "3", "(", "P", "=", "0.0003", ")", "and", "BIRADS", "0", "(", "P", "=", "0.09", ")", ",", "but", "not", "BIRADS", "4/5", "or", "abnormal", "breast", "examinations", ".", "Navigation", "shortened", "the", "time", "for", "both", "colorectal", "(", "P", "=", "0.0017", ")", "and", "prostate", "screening", "resolution", "(", "P", "=", "0.06", ")", ".", "Participant", "demographics", "included", "72", "%", "minority", ",", "49", "%", "with", "annual", "household", "income", "less", "than", "$", "10,000", ",", "and", "36", "%", "uninsured", ".", "CONCLUSIONS", "Patient", "navigation", "positively", "impacts", "time", "to", "resolution", "of", "abnormal", "screening", "tests", "for", "breast", ",", "colorectal", ",", "and", "prostate", "cancers", "in", "a", "medically", "underserved", "population", ".", "IMPACT", "By", "shortening", "the", "time", "to", "and", "increasing", "the", "proportion", "of", "patients", "with", "diagnostic", "resolution", "patient", "navigation", "could", "reduce", "disparities", "in", "stage", "at", "diagnosis", "and", "improve", "cancer", "outcomes", "." ]	[ "Participant_Condition", "Outcome_Other", "Intervention_Control", "Intervention_Educational" ]
Rolle is an umlsterm, Skelettmetastasen is an umlsterm, gezielten is an umlsterm, Metastasensuche is an umlsterm	DerRadiologe.00400826.ger.abstr_task0	Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .	[ "Die", "MRT", "spielt", "eine", "bedeutende", "Rolle", "bei", "der", "diagnostischen", "Abklaerung", "von", "Skelettmetastasen", ".", "Prinzipiell", "kann", "man", "dabei", "2", "Anwendungsbereiche", "der", "MRT", "unterscheiden", ":", "Neben", "dem", "gelaeufigen", "Einsatz", "zur", "Abklaerung", "unklarer", "Befunde", "oder", "der", "gezielten", "hochaufloesenden", "Darstellung", "ossaerer", "Laesionen", "kann", "die", "MRT", "auch", "als", "primaeres", "Screeningverfahren", "zur", "Metastasensuche", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Rolle is an umlsterm, Skelettmetastasen is an umlsterm, gezielten is an umlsterm, Metastasensuche is an umlsterm	DerRadiologe.00400826.ger.abstr_task1	Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please typing these entity words according to sentence: Rolle, Skelettmetastasen, gezielten, Metastasensuche Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .	[ "Die", "MRT", "spielt", "eine", "bedeutende", "Rolle", "bei", "der", "diagnostischen", "Abklaerung", "von", "Skelettmetastasen", ".", "Prinzipiell", "kann", "man", "dabei", "2", "Anwendungsbereiche", "der", "MRT", "unterscheiden", ":", "Neben", "dem", "gelaeufigen", "Einsatz", "zur", "Abklaerung", "unklarer", "Befunde", "oder", "der", "gezielten", "hochaufloesenden", "Darstellung", "ossaerer", "Laesionen", "kann", "die", "MRT", "auch", "als", "primaeres", "Screeningverfahren", "zur", "Metastasensuche", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Rolle, Skelettmetastasen, gezielten, Metastasensuche	DerRadiologe.00400826.ger.abstr_task2	Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .	[ "Die", "MRT", "spielt", "eine", "bedeutende", "Rolle", "bei", "der", "diagnostischen", "Abklaerung", "von", "Skelettmetastasen", ".", "Prinzipiell", "kann", "man", "dabei", "2", "Anwendungsbereiche", "der", "MRT", "unterscheiden", ":", "Neben", "dem", "gelaeufigen", "Einsatz", "zur", "Abklaerung", "unklarer", "Befunde", "oder", "der", "gezielten", "hochaufloesenden", "Darstellung", "ossaerer", "Laesionen", "kann", "die", "MRT", "auch", "als", "primaeres", "Screeningverfahren", "zur", "Metastasensuche", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Env is a Protein, gp120 is a Protein, env is a Protein, Env is a Protein, Env is a Protein, CD4 is a Protein, env is a Protein	183_task0	Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.	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Env is a Protein, gp120 is a Protein, env is a Protein, Env is a Protein, Env is a Protein, CD4 is a Protein, env is a Protein	183_task1	Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please typing these entity words according to sentence: Env, gp120, env, Env, Env, CD4, env Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.	[ "Consistent", "patterns", "of", "change", "during", "the", "divergence", "of", "human", "immunodeficiency", "virus", "type", "1", "envelope", "from", "that", "of", "the", "inoculated", "virus", "in", "simian", "/", "human", "immunodeficiency", "virus", "-", "infected", "macaques", ".", "\n", "We", "have", "analyzed", "changes", "to", "proviral", "Env", "gp120", "sequences", "and", "the", "development", "of", "neutralizing", "antibodies", "(", "NAbs", ")", "during", "1", "year", "of", "simian", "/", "human", "immunodeficiency", "virus", "SHIV-89.6P", "infection", "in", "11", "Macaca", "nemestrina", "macaques", ".", "Seven", "macaques", "had", "significant", "env", "divergence", "from", "that", "of", "the", "inoculum", ",", "and", "macaques", "with", "greater", "divergence", "had", "higher", "titers", "of", "homologous", "NAbs", ".", "Substitutions", "in", "sequons", "encoding", "potential", "N", "-", "linked", "glycosylation", "sites", "(", "PNGs", ")", "were", "among", "the", "first", "to", "be", "established", ",", "although", "overall", "the", "total", "number", "of", "sequons", "did", "not", "increase", "significantly", ".", "The", "majority", "(", "19", "of", "23", ")", "of", "PNGs", "present", "in", "the", "inoculum", "were", "conserved", "in", "the", "sequences", "from", "all", "macaques", ".", "Statistically", "significant", "variations", "in", "PNGs", "occurred", "in", "multiple", "macaques", "within", "constrained", "regions", "we", "term", "\"", "hot", "spots", ",", "\"", "resulting", "in", "the", "selection", "of", "sequences", "more", "similar", "to", "the", "B", "consensus", ".", "These", "included", "additions", "on", "V1", ",", "the", "N", "-", "terminal", "side", "of", "V4", ",", "and", "the", "outer", "region", "of", "C2", ".", "Complex", "mutational", "patterns", "resulted", "in", "convergent", "PNG", "shifts", "in", "V2", "and", "V5", ".", "Charge", "changes", "in", "Env", "V1V2", ",", "resulting", "in", "a", "net", "acidic", "charge", ",", "and", "a", "proline", "addition", "in", "V5", "occurred", "in", "several", "macaques", ".", "Molecular", "modeling", "of", "the", "89.6P", "sequence", "showed", "that", "the", "conserved", "glycans", "lie", "on", "the", "silent", "face", "of", "Env", "and", "that", "many", "are", "proximal", "to", "disulfide", "bonds", ",", "while", "PNG", "additions", "and", "shifts", "are", "proximal", "to", "the", "CD4", "binding", "site", ".", "Nonsynonymous", "-", "to", "-", "synonymous", "substitution", "ratios", "suggest", "that", "these", "changes", "result", "from", "selective", "pressure", ".", "This", "longitudinal", "and", "cross", "-", "sectional", "study", "of", "mutations", "in", "human", "immunodeficiency", "virus", "(", "HIV", ")", "env", "in", "the", "SHIV", "background", "provides", "evidence", "that", "there", "are", "more", "constraints", "on", "the", "configuration", "of", "the", "glycan", "shield", "than", "were", "previously", "appreciated", ".", "\n" ]	[ "Protein" ]
Env, gp120, env, Env, Env, CD4, env	183_task2	Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.	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Psychosen is an umlsterm, Beobachtung is an umlsterm, Arbeit is an umlsterm, Pole is an umlsterm, Achsensyndrome is an umlsterm, Achsensyndrome is an umlsterm, Aufbauelemente is an umlsterm, Affektausdruck is an umlsterm, Affekt is an umlsterm, Denkens is an umlsterm	DerNervenarzt.80690228.ger.abstr_task0	Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .	[ "Der", "Begriff", "\"", "zykloide", "Psychosen", "\"", "bezeichnet", "eine", "zunaechst", "nach", "dem", "Erscheinungsbild", "abzugrenzende", "Art", "innerhalb", "der", "Gattung", "\"", "schizophrener", "Formenkreis", "\"", ".", "Ausgehend", "von", "der", "klinischen", "Beobachtung", "wird", "in", "der", "vorliegenden", "phaenomenologisch", "-", "konzeptuellen", "Arbeit", "die", "Auffassung", "vertreten", ",", "dass", "die", "Leonhardschen", "Subtypen", "bzw", ".", "deren", "jeweilige", "Pole", "als", "Achsensyndrome", "zu", "begreifen", "sind", ",", "die", "waehrend", "ein", "und", "derselben", "Episode", "gemeinsam", "auftreten", "und", "ineinander", "uebergehen", "koennen", ".", "Die", "inneren", "\"", "Zusammenhaenge", "\"", "dieser", "Achsensyndrome", "werden", "herausgearbeitet", ".", "Neben", "dem", "kongruenten", "Verweisungscharakter", "ihrer", "Aufbauelemente", "erweist", "sich", "dabei", "das", "Fehlen", "struktureller", "Verformungen", "1", ".", "von", "Affektausdruck", "und", "Affekt", ",", "2", ".", "des", "Denkens", "und", "3", ".", "der", "Bewegungsimpulse", "und", "-ablaeufe", "als", "entscheidende", "Differentia", "specifica", "gegenueber", "einer", "schizophrenen", "Kerngruppe", ".", "Unseren", "praezisierten", "Phaenomenbegriff", "machen", "wir", "zur", "Grundlage", "einer", "Kritik", "bisheriger", "Operationalisierungsvorschlaege", ",", "fuer", "die", "wir", "eine", "Alternative", "anbieten", "." ]	[ "umlsterm" ]
Psychosen is an umlsterm, Beobachtung is an umlsterm, Arbeit is an umlsterm, Pole is an umlsterm, Achsensyndrome is an umlsterm, Achsensyndrome is an umlsterm, Aufbauelemente is an umlsterm, Affektausdruck is an umlsterm, Affekt is an umlsterm, Denkens is an umlsterm	DerNervenarzt.80690228.ger.abstr_task1	Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please typing these entity words according to sentence: Psychosen, Beobachtung, Arbeit, Pole, Achsensyndrome, Achsensyndrome, Aufbauelemente, Affektausdruck, Affekt, Denkens Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .	[ "Der", "Begriff", "\"", "zykloide", "Psychosen", "\"", "bezeichnet", "eine", "zunaechst", "nach", "dem", "Erscheinungsbild", "abzugrenzende", "Art", "innerhalb", "der", "Gattung", "\"", "schizophrener", "Formenkreis", "\"", ".", "Ausgehend", "von", "der", "klinischen", "Beobachtung", "wird", "in", "der", "vorliegenden", "phaenomenologisch", "-", "konzeptuellen", "Arbeit", "die", "Auffassung", "vertreten", ",", "dass", "die", "Leonhardschen", "Subtypen", "bzw", ".", "deren", "jeweilige", "Pole", "als", "Achsensyndrome", "zu", "begreifen", "sind", ",", "die", "waehrend", "ein", "und", "derselben", "Episode", "gemeinsam", "auftreten", "und", "ineinander", "uebergehen", "koennen", ".", "Die", "inneren", "\"", "Zusammenhaenge", "\"", "dieser", "Achsensyndrome", "werden", "herausgearbeitet", ".", "Neben", "dem", "kongruenten", "Verweisungscharakter", "ihrer", "Aufbauelemente", "erweist", "sich", "dabei", "das", "Fehlen", "struktureller", "Verformungen", "1", ".", "von", "Affektausdruck", "und", "Affekt", ",", "2", ".", "des", "Denkens", "und", "3", ".", "der", "Bewegungsimpulse", "und", "-ablaeufe", "als", "entscheidende", "Differentia", "specifica", "gegenueber", "einer", "schizophrenen", "Kerngruppe", ".", "Unseren", "praezisierten", "Phaenomenbegriff", "machen", "wir", "zur", "Grundlage", "einer", "Kritik", "bisheriger", "Operationalisierungsvorschlaege", ",", "fuer", "die", "wir", "eine", "Alternative", "anbieten", "." ]	[ "umlsterm" ]
Psychosen, Beobachtung, Arbeit, Pole, Achsensyndrome, Achsensyndrome, Aufbauelemente, Affektausdruck, Affekt, Denkens	DerNervenarzt.80690228.ger.abstr_task2	Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .	[ "Der", "Begriff", "\"", "zykloide", "Psychosen", "\"", "bezeichnet", "eine", "zunaechst", "nach", "dem", "Erscheinungsbild", "abzugrenzende", "Art", "innerhalb", "der", "Gattung", "\"", "schizophrener", "Formenkreis", "\"", ".", "Ausgehend", "von", "der", "klinischen", "Beobachtung", "wird", "in", "der", "vorliegenden", "phaenomenologisch", "-", "konzeptuellen", "Arbeit", "die", "Auffassung", "vertreten", ",", "dass", "die", "Leonhardschen", "Subtypen", "bzw", ".", "deren", "jeweilige", "Pole", "als", "Achsensyndrome", "zu", "begreifen", "sind", ",", "die", "waehrend", "ein", "und", "derselben", "Episode", "gemeinsam", "auftreten", "und", "ineinander", "uebergehen", "koennen", ".", "Die", "inneren", "\"", "Zusammenhaenge", "\"", "dieser", "Achsensyndrome", "werden", "herausgearbeitet", ".", "Neben", "dem", "kongruenten", "Verweisungscharakter", "ihrer", "Aufbauelemente", "erweist", "sich", "dabei", "das", "Fehlen", "struktureller", "Verformungen", "1", ".", "von", "Affektausdruck", "und", "Affekt", ",", "2", ".", "des", "Denkens", "und", "3", ".", "der", "Bewegungsimpulse", "und", "-ablaeufe", "als", "entscheidende", "Differentia", "specifica", "gegenueber", "einer", "schizophrenen", "Kerngruppe", ".", "Unseren", "praezisierten", "Phaenomenbegriff", "machen", "wir", "zur", "Grundlage", "einer", "Kritik", "bisheriger", "Operationalisierungsvorschlaege", ",", "fuer", "die", "wir", "eine", "Alternative", "anbieten", "." ]	[ "umlsterm" ]
1,25-dihydroxyvitamin D is a compound, VDR is a protein	DS.d1597_task0	Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.	[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]	[ "compound", "protein" ]
1,25-dihydroxyvitamin D is a compound, VDR is a protein	DS.d1597_task1	Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please typing these entity words according to sentence: 1,25-dihydroxyvitamin D, VDR Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.	[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]	[ "compound", "protein" ]
1,25-dihydroxyvitamin D, VDR	DS.d1597_task2	Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.	[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]	[ "compound", "protein" ]
Skin diseases is an umlsterm, patients is an umlsterm, evaluation is an umlsterm, medicine is an umlsterm, resource is an umlsterm, diagnosis is an umlsterm, guidelines is an umlsterm, evaluation is an umlsterm, role is an umlsterm, evaluation is an umlsterm, evaluation is an umlsterm, occupationally - related is an umlsterm, disorders is an umlsterm, multiple chemical sensitivity is an umlsterm	DerHautarzt.80490626.eng.abstr_task0	Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .	[ "Skin", "diseases", ",", "the", "psyche", "and", "psychological", "changes", "are", "often", "intertwined", ",", "especially", "in", "patients", "presenting", "for", "expert", "dermatologic", "opinion", ".", "In", "many", "cases", "an", "additional", "evaluation", "provided", "by", "psychotherapeutic", "medicine", "may", "be", "necessary", ".", "This", "resource", "may", "help", "with", "the", "diagnosis", ",", "explanation", "of", "the", "problem", "and", "estimation", "of", "the", "degree", "of", "disability", ".", "The", "different", "legal", "guidelines", "of", "the", "various", "evaluation", "boards", "must", "be", "considered", ".", "The", "role", "of", "psychotherapeutic", "evaluation", "is", "demonstrated", "through", "case", "examples", ".", "The", "evaluation", "of", "new", "possibly", "occupationally", "-", "related", "disorders", "such", "as", "multiple", "chemical", "sensitivity", "and", "mobbing", "is", "considered", "." ]	[ "umlsterm" ]
Skin diseases is an umlsterm, patients is an umlsterm, evaluation is an umlsterm, medicine is an umlsterm, resource is an umlsterm, diagnosis is an umlsterm, guidelines is an umlsterm, evaluation is an umlsterm, role is an umlsterm, evaluation is an umlsterm, evaluation is an umlsterm, occupationally - related is an umlsterm, disorders is an umlsterm, multiple chemical sensitivity is an umlsterm	DerHautarzt.80490626.eng.abstr_task1	Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please typing these entity words according to sentence: Skin diseases, patients, evaluation, medicine, resource, diagnosis, guidelines, evaluation, role, evaluation, evaluation, occupationally - related, disorders, multiple chemical sensitivity Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .	[ "Skin", "diseases", ",", "the", "psyche", "and", "psychological", "changes", "are", "often", "intertwined", ",", "especially", "in", "patients", "presenting", "for", "expert", "dermatologic", "opinion", ".", "In", "many", "cases", "an", "additional", "evaluation", "provided", "by", "psychotherapeutic", "medicine", "may", "be", "necessary", ".", "This", "resource", "may", "help", "with", "the", "diagnosis", ",", "explanation", "of", "the", "problem", "and", "estimation", "of", "the", "degree", "of", "disability", ".", "The", "different", "legal", "guidelines", "of", "the", "various", "evaluation", "boards", "must", "be", "considered", ".", "The", "role", "of", "psychotherapeutic", "evaluation", "is", "demonstrated", "through", "case", "examples", ".", "The", "evaluation", "of", "new", "possibly", "occupationally", "-", "related", "disorders", "such", "as", "multiple", "chemical", "sensitivity", "and", "mobbing", "is", "considered", "." ]	[ "umlsterm" ]
Skin diseases, patients, evaluation, medicine, resource, diagnosis, guidelines, evaluation, role, evaluation, evaluation, occupationally - related, disorders, multiple chemical sensitivity	DerHautarzt.80490626.eng.abstr_task2	Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .	[ "Skin", "diseases", ",", "the", "psyche", "and", "psychological", "changes", "are", "often", "intertwined", ",", "especially", "in", "patients", "presenting", "for", "expert", "dermatologic", "opinion", ".", "In", "many", "cases", "an", "additional", "evaluation", "provided", "by", "psychotherapeutic", "medicine", "may", "be", "necessary", ".", "This", "resource", "may", "help", "with", "the", "diagnosis", ",", "explanation", "of", "the", "problem", "and", "estimation", "of", "the", "degree", "of", "disability", ".", "The", "different", "legal", "guidelines", "of", "the", "various", "evaluation", "boards", "must", "be", "considered", ".", "The", "role", "of", "psychotherapeutic", "evaluation", "is", "demonstrated", "through", "case", "examples", ".", "The", "evaluation", "of", "new", "possibly", "occupationally", "-", "related", "disorders", "such", "as", "multiple", "chemical", "sensitivity", "and", "mobbing", "is", "considered", "." ]	[ "umlsterm" ]
PMLRARalpha transgene is a DNA_domain_or_region, murine acute promyelocytic leukemia is an other_name	63364_task0	Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, other_name	[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.	[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]	[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]
PMLRARalpha transgene is a DNA_domain_or_region, murine acute promyelocytic leukemia is an other_name	63364_task1	Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please typing these entity words according to sentence: PMLRARalpha transgene, murine acute promyelocytic leukemia Options: DNA_domain_or_region, other_name	[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.	[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]	[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]
PMLRARalpha transgene, murine acute promyelocytic leukemia	63364_task2	Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please extract entity words from the input sentence	[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]	A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.	[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]	[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]
Short- and long - term effects is a Outcome_Physical, tactile massage is a Intervention_Physical, salivary cortisol concentrations is a Outcome_Physical, Parkinson ' s disease is a Participant_Condition, non - pharmacological therapies is a Intervention_Other, hypothalamic - pituitary - adrenal ( HPA ) axis . is a Outcome_Physical, basal diurnal and total secretion of salivary cortisol is a Outcome_Physical, tactile massage ( TM ) is a Intervention_Physical, Forty - five is a Participant_Sample-size, women and men is a Participant_Sex, aged 50 - 79 years is a Participant_Age, Twenty - nine is a Participant_Sample-size, 16 is a Participant_Sample-size, rest to music ( RTM ) is a Intervention_Control, Salivary cortisol is a Outcome_Physical, assess and compare cortisol concentrations is a Outcome_Physical, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration . is a Outcome_Physical, median cortisol concentrations is a Outcome_Physical, Cortisol concentrations is a Outcome_Physical, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . is a Outcome_Physical, Diurnal salivary cortisol rhythm is a Outcome_Physical, Salivary cortisol concentrations is a Outcome_Physical	62949_task0	Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Control, Intervention_Other, Outcome_Physical, Participant_Age, Participant_Sample-size	[ "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .	[ "Short-", "and", "long", "-", "term", "effects", "of", "tactile", "massage", "on", "salivary", "cortisol", "concentrations", "in", "Parkinson", "'", "s", "disease", ":", "a", "randomised", "controlled", "pilot", "study", ".", "BACKGROUND", "Parkinson", "'", "s", "disease", "(", "PD", ")", "is", "a", "chronic", "neurodegenerative", "disorder", "with", "limited", "knowledge", "about", "the", "normal", "function", "and", "effects", "of", "non", "-", "pharmacological", "therapies", "on", "the", "hypothalamic", "-", "pituitary", "-", "adrenal", "(", "HPA", ")", "axis", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "basal", "diurnal", "and", "total", "secretion", "of", "salivary", "cortisol", "in", "short-", "and", "long", "-", "term", "aspects", "of", "tactile", "massage", "(", "TM", ")", ".", "METHODS", "DESIGN", "Prospective", ",", "Controlled", "and", "Randomised", "Multicentre", "Trial", ".", "SETTING", "AND", "INTERVENTIONS", "Forty", "-", "five", "women", "and", "men", ",", "aged", "50", "-", "79", "years", ",", "were", "recruited", ".", "Twenty", "-", "nine", "of", "them", "were", "blindly", "randomised", "to", "tactile", "massage", "(", "TM", ")", "and", "16", "of", "them", "to", "the", "control", "group", ",", "rest", "to", "music", "(", "RTM", ")", ".", "Ten", "interventions", "were", "given", "during", "8", "weeks", "followed", "by", "a", "26", "weeks", "of", "follow", "up", ".", "Salivary", "cortisol", "was", "collected", "at", "8", "am", ",", "1", "pm", ",", "8", "pm", ",", "and", "8", "am", "the", "next", "day", ",", "on", "five", "occasions", ".", "With", "the", "first", "and", "eighth", "interventions", ",", "it", "was", "collected", "immediately", "before", "and", "after", "intervention", ".", "MAIN", "OUTCOME", "MEASURES", "The", "primary", "aim", "was", "to", "assess", "and", "compare", "cortisol", "concentrations", "before", "and", "immediately", "after", "intervention", "and", "also", "during", "the", "follow", "-", "up", "period", ".", "The", "secondary", "aim", "was", "to", "assess", "the", "impact", "of", "age", ",", "gender", ",", "body", "mass", "index", "(", "BMI", ")", ",", "duration", "and", "severity", "of", "PD", ",", "effects", "of", "interventional", "time", "-", "point", "of", "the", "day", ",", "and", "levodopa", "doses", "on", "cortisol", "concentration", ".", "RESULTS", "The", "median", "cortisol", "concentrations", "for", "all", "participants", "were", "16.0", ",", "5.8", ",", "2.8", ",", "and", "14.0", "nmol", "/", "L", "at", "baseline", ",", "later", "reproduced", "four", "times", "without", "significant", "differences", ".", "Cortisol", "concentrations", "decreased", "significantly", "after", "TM", "intervention", "but", "no", "change", "in", "diurnal", "salivary", "cortisol", "pattern", "was", "found", ".", "The", "findings", "of", "reduced", "salivary", "cortisol", "concentrations", "immediately", "after", "the", "interventions", "are", "in", "agreement", "with", "previous", "studies", ".", "However", ",", "there", "was", "no", "significant", "difference", "between", "the", "TM", "and", "control", "groups", ".", "There", "were", "no", "significant", "correlations", "between", "cortisol", "concentrations", "and", "age", ",", "gender", ",", "BMI", ",", "time", "-", "point", "for", "intervention", ",", "time", "interval", "between", "anti", "-", "parkinson", "pharmacy", "intake", "and", "sampling", ",", "levodopa", "doses", ",", "duration", ",", "or", "severity", "of", "PD", ".", "CONCLUSIONS", "Diurnal", "salivary", "cortisol", "rhythm", "was", "normal", ".", "Salivary", "cortisol", "concentrations", "were", "significantly", "reduced", "after", "the", "TM", "intervention", "and", "after", "RTM", ",", "but", "there", "were", "no", "significant", "differences", "between", "the", "groups", "and", "no", "sustained", "long", "-", "term", "effect", ".", "No", "associations", "were", "seen", "between", "salivary", "cortisol", "concentration", "and", "clinical", "and", "/", "or", "pharmacological", "characteristics", ".", "TRIAL", "REGISTRATION", "ClinicalTrial.gov", ",", "NCT01734876", "and", "FoU", "Sweden", "108881", "." ]	[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]
Short- and long - term effects is a Outcome_Physical, tactile massage is a Intervention_Physical, salivary cortisol concentrations is a Outcome_Physical, Parkinson ' s disease is a Participant_Condition, non - pharmacological therapies is a Intervention_Other, hypothalamic - pituitary - adrenal ( HPA ) axis . is a Outcome_Physical, basal diurnal and total secretion of salivary cortisol is a Outcome_Physical, tactile massage ( TM ) is a Intervention_Physical, Forty - five is a Participant_Sample-size, women and men is a Participant_Sex, aged 50 - 79 years is a Participant_Age, Twenty - nine is a Participant_Sample-size, 16 is a Participant_Sample-size, rest to music ( RTM ) is a Intervention_Control, Salivary cortisol is a Outcome_Physical, assess and compare cortisol concentrations is a Outcome_Physical, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration . is a Outcome_Physical, median cortisol concentrations is a Outcome_Physical, Cortisol concentrations is a Outcome_Physical, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . is a Outcome_Physical, Diurnal salivary cortisol rhythm is a Outcome_Physical, Salivary cortisol concentrations is a Outcome_Physical	62949_task1	Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . Instructions: please typing these entity words according to sentence: Short- and long - term effects, tactile massage, salivary cortisol concentrations, Parkinson ' s disease, non - pharmacological therapies, hypothalamic - pituitary - adrenal ( HPA ) axis ., basal diurnal and total secretion of salivary cortisol, tactile massage ( TM ), Forty - five, women and men, aged 50 - 79 years, Twenty - nine, 16, rest to music ( RTM ), Salivary cortisol, assess and compare cortisol concentrations, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration ., median cortisol concentrations, Cortisol concentrations, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD ., Diurnal salivary cortisol rhythm, Salivary cortisol concentrations Options: 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BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .	[ "Short-", "and", "long", "-", "term", "effects", "of", "tactile", "massage", "on", "salivary", "cortisol", "concentrations", "in", "Parkinson", "'", "s", "disease", ":", "a", "randomised", "controlled", "pilot", "study", ".", "BACKGROUND", "Parkinson", "'", "s", "disease", "(", "PD", ")", "is", "a", "chronic", "neurodegenerative", "disorder", "with", "limited", "knowledge", "about", "the", "normal", "function", "and", "effects", "of", "non", "-", "pharmacological", "therapies", "on", "the", "hypothalamic", "-", "pituitary", "-", "adrenal", "(", "HPA", ")", "axis", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "basal", "diurnal", "and", "total", "secretion", "of", "salivary", "cortisol", "in", "short-", "and", "long", "-", "term", "aspects", "of", "tactile", "massage", "(", "TM", ")", ".", "METHODS", "DESIGN", "Prospective", ",", "Controlled", "and", "Randomised", "Multicentre", "Trial", ".", "SETTING", "AND", "INTERVENTIONS", "Forty", "-", "five", "women", "and", "men", ",", "aged", "50", "-", "79", "years", ",", "were", "recruited", ".", "Twenty", "-", "nine", "of", "them", "were", "blindly", "randomised", "to", "tactile", "massage", "(", "TM", ")", "and", "16", "of", "them", "to", "the", "control", "group", ",", "rest", "to", "music", "(", "RTM", ")", ".", "Ten", "interventions", "were", "given", "during", "8", "weeks", "followed", "by", "a", "26", "weeks", "of", "follow", "up", ".", "Salivary", "cortisol", "was", "collected", "at", "8", "am", ",", "1", "pm", ",", "8", "pm", ",", "and", "8", "am", "the", "next", "day", ",", "on", "five", "occasions", ".", "With", "the", "first", "and", "eighth", "interventions", ",", "it", "was", "collected", "immediately", "before", "and", "after", "intervention", ".", "MAIN", "OUTCOME", "MEASURES", "The", "primary", "aim", "was", "to", "assess", "and", "compare", "cortisol", "concentrations", "before", "and", "immediately", "after", "intervention", "and", "also", "during", "the", "follow", "-", "up", "period", ".", "The", "secondary", "aim", "was", "to", "assess", "the", "impact", "of", "age", ",", "gender", ",", "body", "mass", "index", "(", "BMI", ")", ",", "duration", "and", "severity", "of", "PD", ",", "effects", "of", "interventional", "time", "-", "point", "of", "the", "day", ",", "and", "levodopa", "doses", "on", "cortisol", "concentration", ".", "RESULTS", "The", "median", "cortisol", "concentrations", "for", "all", "participants", "were", "16.0", ",", "5.8", ",", "2.8", ",", "and", "14.0", "nmol", "/", "L", "at", "baseline", ",", "later", "reproduced", "four", "times", "without", "significant", "differences", ".", "Cortisol", "concentrations", "decreased", "significantly", "after", "TM", "intervention", "but", "no", "change", "in", "diurnal", "salivary", "cortisol", "pattern", "was", "found", ".", "The", "findings", "of", "reduced", "salivary", "cortisol", "concentrations", "immediately", "after", "the", "interventions", "are", "in", "agreement", "with", "previous", "studies", ".", "However", ",", "there", "was", "no", "significant", "difference", "between", "the", "TM", "and", "control", "groups", ".", "There", "were", "no", "significant", "correlations", "between", "cortisol", "concentrations", "and", "age", ",", "gender", ",", "BMI", ",", "time", "-", "point", "for", "intervention", ",", "time", "interval", "between", "anti", "-", "parkinson", "pharmacy", "intake", "and", "sampling", ",", "levodopa", "doses", ",", "duration", ",", "or", "severity", "of", "PD", ".", "CONCLUSIONS", "Diurnal", "salivary", "cortisol", "rhythm", "was", "normal", ".", "Salivary", "cortisol", "concentrations", "were", "significantly", "reduced", "after", "the", "TM", "intervention", "and", "after", "RTM", ",", "but", "there", "were", "no", "significant", "differences", "between", "the", "groups", "and", "no", "sustained", "long", "-", "term", "effect", ".", "No", "associations", "were", "seen", "between", "salivary", "cortisol", "concentration", "and", "clinical", "and", "/", "or", "pharmacological", "characteristics", ".", "TRIAL", "REGISTRATION", "ClinicalTrial.gov", ",", "NCT01734876", "and", "FoU", "Sweden", "108881", "." ]	[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]
Short- and long - term effects, tactile massage, salivary cortisol concentrations, Parkinson ' s disease, non - pharmacological therapies, hypothalamic - pituitary - adrenal ( HPA ) axis ., basal diurnal and total secretion of salivary cortisol, tactile massage ( TM ), Forty - five, women and men, aged 50 - 79 years, Twenty - nine, 16, rest to music ( RTM ), Salivary cortisol, assess and compare cortisol concentrations, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration ., median cortisol concentrations, Cortisol concentrations, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD ., Diurnal salivary cortisol rhythm, Salivary cortisol concentrations	62949_task2	Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .	[ "Short-", "and", "long", "-", "term", "effects", "of", "tactile", "massage", "on", "salivary", "cortisol", "concentrations", "in", "Parkinson", "'", "s", "disease", ":", "a", "randomised", "controlled", "pilot", "study", ".", "BACKGROUND", "Parkinson", "'", "s", "disease", "(", "PD", ")", "is", "a", "chronic", "neurodegenerative", "disorder", "with", "limited", "knowledge", "about", "the", "normal", "function", "and", "effects", "of", "non", "-", "pharmacological", "therapies", "on", "the", "hypothalamic", "-", "pituitary", "-", "adrenal", "(", "HPA", ")", "axis", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "basal", "diurnal", "and", "total", "secretion", "of", "salivary", "cortisol", "in", "short-", "and", "long", "-", "term", "aspects", "of", "tactile", "massage", "(", "TM", ")", ".", "METHODS", "DESIGN", "Prospective", ",", "Controlled", "and", "Randomised", "Multicentre", "Trial", ".", "SETTING", "AND", "INTERVENTIONS", "Forty", "-", "five", "women", "and", "men", ",", "aged", "50", "-", "79", "years", ",", "were", "recruited", ".", "Twenty", "-", "nine", "of", "them", "were", "blindly", "randomised", "to", "tactile", "massage", "(", "TM", ")", "and", "16", "of", "them", "to", "the", "control", "group", ",", "rest", "to", "music", "(", "RTM", ")", ".", "Ten", "interventions", "were", "given", "during", "8", "weeks", "followed", "by", "a", "26", "weeks", "of", "follow", "up", ".", "Salivary", "cortisol", "was", "collected", "at", "8", "am", ",", "1", "pm", ",", "8", "pm", ",", "and", "8", "am", "the", "next", "day", ",", "on", "five", "occasions", ".", "With", "the", "first", "and", "eighth", "interventions", ",", "it", "was", "collected", "immediately", "before", "and", "after", "intervention", ".", "MAIN", "OUTCOME", "MEASURES", "The", "primary", "aim", "was", "to", "assess", "and", "compare", "cortisol", "concentrations", "before", "and", "immediately", "after", "intervention", "and", "also", "during", "the", "follow", "-", "up", "period", ".", "The", "secondary", "aim", "was", "to", "assess", "the", "impact", "of", "age", ",", "gender", ",", "body", "mass", "index", "(", "BMI", ")", ",", "duration", "and", "severity", "of", "PD", ",", "effects", "of", "interventional", "time", "-", "point", "of", "the", "day", ",", "and", "levodopa", "doses", "on", "cortisol", "concentration", ".", "RESULTS", "The", "median", "cortisol", "concentrations", "for", "all", "participants", "were", "16.0", ",", "5.8", ",", "2.8", ",", "and", "14.0", "nmol", "/", "L", "at", "baseline", ",", "later", "reproduced", "four", "times", "without", "significant", "differences", ".", "Cortisol", "concentrations", "decreased", "significantly", "after", "TM", "intervention", "but", "no", "change", "in", "diurnal", "salivary", "cortisol", "pattern", "was", "found", ".", "The", "findings", "of", "reduced", "salivary", "cortisol", "concentrations", "immediately", "after", "the", "interventions", "are", "in", "agreement", "with", "previous", "studies", ".", "However", ",", "there", "was", "no", "significant", "difference", "between", "the", "TM", "and", "control", "groups", ".", "There", "were", "no", "significant", "correlations", "between", "cortisol", "concentrations", "and", "age", ",", "gender", ",", "BMI", ",", "time", "-", "point", "for", "intervention", ",", "time", "interval", "between", "anti", "-", "parkinson", "pharmacy", "intake", "and", "sampling", ",", "levodopa", "doses", ",", "duration", ",", "or", "severity", "of", "PD", ".", "CONCLUSIONS", "Diurnal", "salivary", "cortisol", "rhythm", "was", "normal", ".", "Salivary", "cortisol", "concentrations", "were", "significantly", "reduced", "after", "the", "TM", "intervention", "and", "after", "RTM", ",", "but", "there", "were", "no", "significant", "differences", "between", "the", "groups", "and", "no", "sustained", "long", "-", "term", "effect", ".", "No", "associations", "were", "seen", "between", "salivary", "cortisol", "concentration", "and", "clinical", "and", "/", "or", "pharmacological", "characteristics", ".", "TRIAL", "REGISTRATION", "ClinicalTrial.gov", ",", "NCT01734876", "and", "FoU", "Sweden", "108881", "." ]	[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]
Whipple operation is an umlsterm, standard is an umlsterm, operation is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, duodenopancreatectomy is an umlsterm, function is an umlsterm, Methods is an umlsterm, October is an umlsterm, quality of life is an umlsterm, operation is an umlsterm, time is an umlsterm, hospital is an umlsterm, morbidity is an umlsterm, Quality of life is an umlsterm, duodenopancreatectomy is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, age is an umlsterm, gender is an umlsterm, stage is an umlsterm, Operation is an umlsterm, time is an umlsterm, Morbidity is an umlsterm, quality of life is an umlsterm, quality of life is an umlsterm, appetite is an umlsterm, nausea is an umlsterm, diarrhea is an umlsterm, body weight is an umlsterm, postoperative is an umlsterm, quality of life is an umlsterm	DerChirurg.90701454.eng.abstr_task0	Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . 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However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .	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Whipple operation is an umlsterm, standard is an umlsterm, operation is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, duodenopancreatectomy is an umlsterm, function is an umlsterm, Methods is an umlsterm, October is an umlsterm, quality of life is an umlsterm, operation is an umlsterm, time is an umlsterm, hospital is an umlsterm, morbidity is an umlsterm, Quality of life is an umlsterm, duodenopancreatectomy is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, age is an umlsterm, gender is an umlsterm, stage is an umlsterm, Operation is an umlsterm, time is an umlsterm, Morbidity is an umlsterm, quality of life is an umlsterm, quality of life is an umlsterm, appetite is an umlsterm, nausea is an umlsterm, diarrhea is an umlsterm, body weight is an umlsterm, postoperative is an umlsterm, quality of life is an umlsterm	DerChirurg.90701454.eng.abstr_task1	Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . Instructions: please typing these entity words according to sentence: Whipple operation, standard, operation, patients, cancer, head, pancreas, duodenopancreatectomy, function, Methods, October, quality of life, operation, time, hospital, morbidity, Quality of life, duodenopancreatectomy, patients, cancer, head, pancreas, age, gender, stage, Operation, time, Morbidity, quality of life, quality of life, appetite, nausea, diarrhea, body weight, postoperative, quality of life Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O" ]	Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .	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Whipple operation, standard, operation, patients, cancer, head, pancreas, duodenopancreatectomy, function, Methods, October, quality of life, operation, time, hospital, morbidity, Quality of life, duodenopancreatectomy, patients, cancer, head, pancreas, age, gender, stage, Operation, time, Morbidity, quality of life, quality of life, appetite, nausea, diarrhea, body weight, postoperative, quality of life	DerChirurg.90701454.eng.abstr_task2	Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . 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However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .	[ "Background", ":", "The", "Whipple", "operation", "(", "PD", ")", "is", "the", "standard", "operation", "in", "patients", "with", "cancer", "of", "the", "head", "of", "the", "pancreas", "and", "the", "periampullary", "region", ".", "However", ",", "the", "pylorus", "-", "preserving", "duodenopancreatectomy", "(", "PPPD", ")", "is", "supposed", "to", "be", "superior", "in", "gastrointestinal", "function", ".", "Methods", ":", "In", "a", "prospective", "randomized", "trial", "(", "October", "1994-October", "1998", ")", "PD", "and", "PPPD", "were", "compared", "in", "terms", "of", "global", "and", "gastrointestinal", "quality", "of", "life", ",", "operation", "time", ",", "duration", "of", "hospital", "stay", ",", "transfusions", "and", "perioperative", "morbidity", ".", "Quality", "of", "life", "was", "analyzed", "under", "standardized", "conditions", "(", "EORTC", "-", "QLQ-30", ")", "pre-", "and", "postoperatively", "(", "weeks", "2", ",", "6", ",", "12", ",", "24", ",", "36", ",", "48", ",", "and", "60", ")", ".", "Results", ":", "A", "duodenopancreatectomy", "was", "performed", "in", "48", "patients", "because", "of", "cancer", "of", "the", "head", "of", "the", "pancreas", "(", "n", "=", "38", ")", "and", "the", "periampullary", "region", "(", "n", "=", "10", ")", "(", "PD", ",", "n", "=", "24", ";", "PPPD", ",", "n", "=", "24", ")", ".", "The", "PD", "and", "PPPD", "groups", "did", "not", "differ", "according", "to", "age", ",", "gender", "or", "UICC", "stage", ".", "Operation", "time", "was", "shorter", "in", "the", "PPPD", "group", "(", "206", "+", "/-", "48", "vs", "306", "+", "/-", "54", "min", ")", "(", "P", "0.05", ")", ".", "Morbidity", "did", "not", "differ", "between", "the", "two", "groups", "(", "PPPD", "20", "%", "vs", "PD", "30", "%", ",", "P", ">", "0.05", ")", ".", "While", "there", "was", "no", "difference", "in", "global", "quality", "of", "life", ",", "gastrointestinal", "quality", "of", "life", "was", "postoperatively", "increased", "in", "the", "PPPD", "group", "regarding", "appetite", ",", "nausea", "and", "diarrhea", "(", "P", "0.05", ")", ".", "While", "the", "preoperative", "body", "weight", "was", "reached", "after", "6", "months", "in", "85", "%", "of", "the", "PPPD", "group", "(", "n", "=", "20", ")", ",", "this", "was", "true", "in", "only", "60", "%", "of", "the", "PD", "-", "group", "(", "n", "=", "14", ")", "(", "P", "0.05", ")", ".", "Conclusion", ":", "PPPD", "seems", "to", "be", "associated", "with", "a", "better", "postoperative", "gastrointestinal", "quality", "of", "life", "than", "PD", "." ]	[ "umlsterm" ]
dream is an umlsterm, hospital is an umlsterm, computer is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, discharge is an umlsterm, patients is an umlsterm, hospital information systems is an umlsterm, information systems is an umlsterm, environment is an umlsterm, discharge is an umlsterm, administration is an umlsterm, universal is an umlsterm, solution is an umlsterm, communication is an umlsterm, information systems is an umlsterm	DerGynaekologe.00330194.eng.abstr_task0	Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .	[ "The", "dream", "of", "every", "hospital", "computer", "scientist", "is", "a", "completely", "computerized", "flow", "of", "information", "in", "his", "/", "her", "facility", ":", "admission", ",", "diagnosis", ",", "treatment", ",", "transfer", ",", "and", "discharge", "of", "patients", ".", "However", ",", "in", "developing", "such", "general", "hospital", "information", "systems", ",", "one", "runs", "into", "the", "following", "problems", ":", "(", "1", ")", "medical", "and", "administrative", "information", "systems", "form", "a", "very", "heterogeneous", "environment", ";", "(", "2", ")", "the", "structure", "of", "medical", "information", "is", "extremely", "complex", ",", "except", "for", "certain", "limited", "administrative", "data", "(", "admission", ",", "transfer", ",", "and", "discharge", ",", "for", "example", ")", "needed", "by", "the", "clinic", "administration", ".", "As", "a", "result", "it", "is", "nearly", "impossible", "to", "transfer", "medical", "information", "from", "one", "system", "to", "another", "without", "a", "loss", "of", "data", ".", "One", "cannot", "expect", "a", "universal", "solution", "to", "this", "problem", "within", "the", "next", "few", "years", ".", "Therefore", "we", "present", "a", "concept", "which", ",", "based", "on", "existing", "tools", ",", "allows", "communication", "between", "medical", "information", "systems", "." ]	[ "umlsterm" ]
dream is an umlsterm, hospital is an umlsterm, computer is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, discharge is an umlsterm, patients is an umlsterm, hospital information systems is an umlsterm, information systems is an umlsterm, environment is an umlsterm, discharge is an umlsterm, administration is an umlsterm, universal is an umlsterm, solution is an umlsterm, communication is an umlsterm, information systems is an umlsterm	DerGynaekologe.00330194.eng.abstr_task1	Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please typing these entity words according to sentence: dream, hospital, computer, diagnosis, treatment, discharge, patients, hospital information systems, information systems, environment, discharge, administration, universal, solution, communication, information systems Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .	[ "The", "dream", "of", "every", "hospital", "computer", "scientist", "is", "a", "completely", "computerized", "flow", "of", "information", "in", "his", "/", "her", "facility", ":", "admission", ",", "diagnosis", ",", "treatment", ",", "transfer", ",", "and", "discharge", "of", "patients", ".", "However", ",", "in", "developing", "such", "general", "hospital", "information", "systems", ",", "one", "runs", "into", "the", "following", "problems", ":", "(", "1", ")", "medical", "and", "administrative", "information", "systems", "form", "a", "very", "heterogeneous", "environment", ";", "(", "2", ")", "the", "structure", "of", "medical", "information", "is", "extremely", "complex", ",", "except", "for", "certain", "limited", "administrative", "data", "(", "admission", ",", "transfer", ",", "and", "discharge", ",", "for", "example", ")", "needed", "by", "the", "clinic", "administration", ".", "As", "a", "result", "it", "is", "nearly", "impossible", "to", "transfer", "medical", "information", "from", "one", "system", "to", "another", "without", "a", "loss", "of", "data", ".", "One", "cannot", "expect", "a", "universal", "solution", "to", "this", "problem", "within", "the", "next", "few", "years", ".", "Therefore", "we", "present", "a", "concept", "which", ",", "based", "on", "existing", "tools", ",", "allows", "communication", "between", "medical", "information", "systems", "." ]	[ "umlsterm" ]
dream, hospital, computer, diagnosis, treatment, discharge, patients, hospital information systems, information systems, environment, discharge, administration, universal, solution, communication, information systems	DerGynaekologe.00330194.eng.abstr_task2	Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .	[ "The", "dream", "of", "every", "hospital", "computer", "scientist", "is", "a", "completely", "computerized", "flow", "of", "information", "in", "his", "/", "her", "facility", ":", "admission", ",", "diagnosis", ",", "treatment", ",", "transfer", ",", "and", "discharge", "of", "patients", ".", "However", ",", "in", "developing", "such", "general", "hospital", "information", "systems", ",", "one", "runs", "into", "the", "following", "problems", ":", "(", "1", ")", "medical", "and", "administrative", "information", "systems", "form", "a", "very", "heterogeneous", "environment", ";", "(", "2", ")", "the", "structure", "of", "medical", "information", "is", "extremely", "complex", ",", "except", "for", "certain", "limited", "administrative", "data", "(", "admission", ",", "transfer", ",", "and", "discharge", ",", "for", "example", ")", "needed", "by", "the", "clinic", "administration", ".", "As", "a", "result", "it", "is", "nearly", "impossible", "to", "transfer", "medical", "information", "from", "one", "system", "to", "another", "without", "a", "loss", "of", "data", ".", "One", "cannot", "expect", "a", "universal", "solution", "to", "this", "problem", "within", "the", "next", "few", "years", ".", "Therefore", "we", "present", "a", "concept", "which", ",", "based", "on", "existing", "tools", ",", "allows", "communication", "between", "medical", "information", "systems", "." ]	[ "umlsterm" ]
paraquat is a CHEMICAL	23261591_task0	Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.	[ "Central", "nervous", "system", "damage", "due", "to", "acute", "paraquat", "poisoning", ":", "an", "experimental", "study", "with", "rat", "model", "." ]	[ "CHEMICAL", "GENE-Y" ]
paraquat is a CHEMICAL	23261591_task1	Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please typing these entity words according to sentence: paraquat Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.	[ "Central", "nervous", "system", "damage", "due", "to", "acute", "paraquat", "poisoning", ":", "an", "experimental", "study", "with", "rat", "model", "." ]	[ "CHEMICAL", "GENE-Y" ]
paraquat	23261591_task2	Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.	[ "Central", "nervous", "system", "damage", "due", "to", "acute", "paraquat", "poisoning", ":", "an", "experimental", "study", "with", "rat", "model", "." ]	[ "CHEMICAL", "GENE-Y" ]
efficacy is a Outcome_Other, atorvastatin is a Intervention_Pharmacological, simvastatin is a Intervention_Pharmacological, pravastatin is a Intervention_Pharmacological, lovastatin is a Intervention_Pharmacological, fluvastatin is a Intervention_Pharmacological, patients with hypercholesterolemia is a Participant_Condition, multicenter is a Participant_Condition, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg is a Intervention_Pharmacological, simvastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, pravastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, lovastatin 20 , 40 , and 80 mg is a Intervention_Pharmacological, fluvastatin 20 and 40 mg . is a Intervention_Pharmacological, 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ) is a Participant_Sample-size, plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations is a Outcome_Physical, Atorvastatin is a Intervention_Pharmacological, tolerability is a Outcome_Mental, serum transaminases or myositis . is a Outcome_Adverse-effects	91483_task0	Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "B-Outcome_Other", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", 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"I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects" ]	Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .	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efficacy is a Outcome_Other, atorvastatin is a Intervention_Pharmacological, simvastatin is a Intervention_Pharmacological, pravastatin is a Intervention_Pharmacological, lovastatin is a Intervention_Pharmacological, fluvastatin is a Intervention_Pharmacological, patients with hypercholesterolemia is a Participant_Condition, multicenter is a Participant_Condition, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg is a Intervention_Pharmacological, simvastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, pravastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, lovastatin 20 , 40 , and 80 mg is a Intervention_Pharmacological, fluvastatin 20 and 40 mg . is a Intervention_Pharmacological, 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ) is a Participant_Sample-size, plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations is a Outcome_Physical, Atorvastatin is a Intervention_Pharmacological, tolerability is a Outcome_Mental, serum transaminases or myositis . is a Outcome_Adverse-effects	91483_task1	Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please typing these entity words according to sentence: efficacy, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, patients with hypercholesterolemia, multicenter, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg, simvastatin 10 , 20 , and 40 mg, pravastatin 10 , 20 , and 40 mg, lovastatin 20 , 40 , and 80 mg, fluvastatin 20 and 40 mg ., 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ), plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations, Atorvastatin, tolerability, serum transaminases or myositis . Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "B-Outcome_Other", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", 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"I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects" ]	Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .	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efficacy, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, patients with hypercholesterolemia, multicenter, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg, simvastatin 10 , 20 , and 40 mg, pravastatin 10 , 20 , and 40 mg, lovastatin 20 , 40 , and 80 mg, fluvastatin 20 and 40 mg ., 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ), plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations, Atorvastatin, tolerability, serum transaminases or myositis .	91483_task2	Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Outcome_Other", "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects" ]	Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .	[ "Comparative", "dose", "efficacy", "study", "of", "atorvastatin", "versus", "simvastatin", ",", "pravastatin", ",", "lovastatin", ",", "and", "fluvastatin", "in", "patients", "with", "hypercholesterolemia", "(", "the", "CURVES", "study", ")", "The", "objective", "of", "this", "multicenter", ",", "randomized", ",", "open", "-", "label", ",", "parallel", "-", "group", ",", "8-week", "study", "was", "to", "evaluate", "the", "comparative", "dose", "efficacy", "of", "the", "3-hydroxy-3-methylglutaryl", "coenzyme", "A", "(", "HMG", "-", "CoA", ")", "reductase", "inhibitor", "atorvastatin", "10", ",", "20", ",", "40", ",", "and", "80", "mg", "compared", "with", "simvastatin", "10", ",", "20", ",", "and", "40", "mg", ",", "pravastatin", "10", ",", "20", ",", "and", "40", "mg", ",", "lovastatin", "20", ",", "40", ",", "and", "80", "mg", ",", "and", "fluvastatin", "20", "and", "40", "mg", ".", "Investigators", "enrolled", "534", "hypercholesterolemic", "patients", "(", "low", "-", "density", "lipoprotein", "[", "LDL", "]", "cholesterol", ">", "or", "=", "160", "mg", "/", "dl", "[", "4.2", "mmol", "/", "L", "]", "and", "triglycerides", "<", "or", "=", "400", "mg", "/", "dl", "[", "4.5", "mmol", "/", "L", "]", ")", ".", "The", "efficacy", "end", "points", "were", "mean", "percent", "change", "in", "plasma", "LDL", "cholesterol", "(", "primary", ")", ",", "total", "cholesterol", ",", "triglycerides", ",", "and", "high", "-", "density", "lipoprotein", "cholesterol", "concentrations", "from", "baseline", "to", "the", "end", "of", "treatment", "(", "week", "8", ")", ".", "Atorvastatin", "10", ",", "20", ",", "and", "40", "mg", "produced", "greater", "(", "p", "<", "or", "=", "0.01", ")", "reductions", "in", "LDL", "cholesterol", ",", "-38", "%", ",", "-46", "%", ",", "and", "-51", "%", ",", "respectively", ",", "than", "the", "milligram", "equivalent", "doses", "of", "simvastatin", ",", "pravastatin", ",", "lovastatin", ",", "and", "fluvastatin", ".", "Atorvastatin", "10", "mg", "produced", "LDL", "cholesterol", "reductions", "comparable", "to", "or", "greater", "than", "(", "p", "<", "or", "=", "0.02", ")", "simvastatin", "10", ",", "20", ",", "and", "40", "mg", ",", "pravastatin", "10", ",", "20", ",", "and", "40", "mg", ",", "lovastatin", "20", "and", "40", "mg", ",", "and", "fluvastatin", "20", "and", "40", "mg", ".", "Atorvastatin", "10", ",", "20", ",", "and", "40", "mg", "produced", "greater", "(", "p", "<", "or", "=", "0.01", ")", "reductions", "in", "total", "cholesterol", "than", "the", "milligram", "equivalent", "doses", "of", "simvastatin", ",", "pravastatin", ",", "lovastatin", ",", "and", "fluvastatin", ".", "All", "reductase", "inhibitors", "studied", "had", "similar", "tolerability", ".", "There", "were", "no", "incidences", "of", "persistent", "elevations", "in", "serum", "transaminases", "or", "myositis", "." ]	[ "Participant_Sample-size", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Mental", "Outcome_Other" ]
Risiko is an umlsterm, Rolle is an umlsterm, Ultraschalltechniken is an umlsterm, Parathormon is an umlsterm, Dehnbarkeit is an umlsterm, Arterien is an umlsterm, niereninsuffizienten is an umlsterm, Patienten is an umlsterm, Parathormonkonzentrationen is an umlsterm, Parathormons is an umlsterm, Uraemie is an umlsterm, Endothel is an umlsterm, erkanntes is an umlsterm, Parathormons is an umlsterm, Patienten is an umlsterm, Hyperparathyreoidismus is an umlsterm, Parathyreoidektomie is an umlsterm, blutdrucksteigernden is an umlsterm, Parathormons is an umlsterm, Arbeit is an umlsterm, Parathormons is an umlsterm, Arterien is an umlsterm, Endothelfunktion is an umlsterm	MedizinischeKlinik.00950267.ger.abstr_task0	Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O" ]	Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .	[ "Funktionelle", "Veraenderungen", "der", "arteriellen", "Gefaesswand", "spielen", "fuer", "das", "kardiovaskulaere", "Risiko", "eine", "wichtige", "Rolle", "und", "lassen", "sich", "mittels", "moderner", "Ultraschalltechniken", "nichtinvasiv", "messen", ".", "Neuere", "Studien", "zeigen", ",", "dass", "Parathormon", "eine", "Reihe", "komplexer", "Effekte", "auf", "das", "kardiovaskulaere", "System", "hat", "und", "neben", "Strukturveraenderungen", "der", "Gefaesswand", "insbesondere", "den", "Tonus", "und", "die", "Dehnbarkeit", "grosser", "Arterien", "beeinflusst", ".", "So", "konnte", "gezeigt", "werden", ",", "dass", "bei", "niereninsuffizienten", "Patienten", "erhoehte", "Parathormonkonzentrationen", "mit", "einer", "Verminderung", "der", "arteriellen", "Distensibilitaet", "und", "einer", "Zunahme", "der", "Intima", "-", "Media", "-", "Dicke", "einhergehen", ".", "Ein", "permissiver", "Effekt", "des", "Parathormons", "fuer", "die", "Gefaesswandveraenderungen", "bei", "Uraemie", "wird", "diskutiert", ".", "Das", "Endothel", "ist", "ein", "neu", "erkanntes", "Zielorgan", "des", "Parathormons", ".", "Bei", "Patienten", "mit", "primaeren", "Hyperparathyreoidismus", "wurde", "eine", "endotheliale", "Dysfunktion", "nachgewiesen", ",", "die", "nach", "Parathyreoidektomie", "reversibel", "ist", ".", "Moeglicherweise", "tragen", "die", "Effekte", "auf", "die", "funktionellen", "Gefaesswandeigenschaften", "zur", "blutdrucksteigernden", "Wirkung", "des", "Parathormons", "bei", ".", "Die", "vorliegende", "Arbeit", "gibt", "einen", "Ueberblick", "ueml", ",", "ber", "die", "kardiovaskulaeren", "Effekte", "des", "Parathormons", "und", "geht", "insbesondere", "auf", "Veraenderungen", "der", "Struktur", ",", "des", "Tonus", ",", "der", "Distensibilitaet", "grosser", "Arterien", "und", "der", "Endothelfunktion", "ein", "." ]	[ "umlsterm" ]
Risiko is an umlsterm, Rolle is an umlsterm, Ultraschalltechniken is an umlsterm, Parathormon is an umlsterm, Dehnbarkeit is an umlsterm, Arterien is an umlsterm, niereninsuffizienten is an umlsterm, Patienten is an umlsterm, Parathormonkonzentrationen is an umlsterm, Parathormons is an umlsterm, Uraemie is an umlsterm, Endothel is an umlsterm, erkanntes is an umlsterm, Parathormons is an umlsterm, Patienten is an umlsterm, Hyperparathyreoidismus is an umlsterm, Parathyreoidektomie is an umlsterm, blutdrucksteigernden is an umlsterm, Parathormons is an umlsterm, Arbeit is an umlsterm, Parathormons is an umlsterm, Arterien is an umlsterm, Endothelfunktion is an umlsterm	MedizinischeKlinik.00950267.ger.abstr_task1	Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please typing these entity words according to sentence: Risiko, Rolle, Ultraschalltechniken, Parathormon, Dehnbarkeit, Arterien, niereninsuffizienten, Patienten, Parathormonkonzentrationen, Parathormons, Uraemie, Endothel, erkanntes, Parathormons, Patienten, Hyperparathyreoidismus, Parathyreoidektomie, blutdrucksteigernden, Parathormons, Arbeit, Parathormons, Arterien, Endothelfunktion Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O" ]	Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .	[ "Funktionelle", "Veraenderungen", "der", "arteriellen", "Gefaesswand", "spielen", "fuer", "das", "kardiovaskulaere", "Risiko", "eine", "wichtige", "Rolle", "und", "lassen", "sich", "mittels", "moderner", "Ultraschalltechniken", "nichtinvasiv", "messen", ".", "Neuere", "Studien", "zeigen", ",", "dass", "Parathormon", "eine", "Reihe", "komplexer", "Effekte", "auf", "das", "kardiovaskulaere", "System", "hat", "und", "neben", "Strukturveraenderungen", "der", "Gefaesswand", "insbesondere", "den", "Tonus", "und", "die", "Dehnbarkeit", "grosser", "Arterien", "beeinflusst", ".", "So", "konnte", "gezeigt", "werden", ",", "dass", "bei", "niereninsuffizienten", "Patienten", "erhoehte", "Parathormonkonzentrationen", "mit", "einer", "Verminderung", "der", "arteriellen", "Distensibilitaet", "und", "einer", "Zunahme", "der", "Intima", "-", "Media", "-", "Dicke", "einhergehen", ".", "Ein", "permissiver", "Effekt", "des", "Parathormons", "fuer", "die", "Gefaesswandveraenderungen", "bei", "Uraemie", "wird", "diskutiert", ".", "Das", "Endothel", "ist", "ein", "neu", "erkanntes", "Zielorgan", "des", "Parathormons", ".", "Bei", "Patienten", "mit", "primaeren", "Hyperparathyreoidismus", "wurde", "eine", "endotheliale", "Dysfunktion", "nachgewiesen", ",", "die", "nach", "Parathyreoidektomie", "reversibel", "ist", ".", "Moeglicherweise", "tragen", "die", "Effekte", "auf", "die", "funktionellen", "Gefaesswandeigenschaften", "zur", "blutdrucksteigernden", "Wirkung", "des", "Parathormons", "bei", ".", "Die", "vorliegende", "Arbeit", "gibt", "einen", "Ueberblick", "ueml", ",", "ber", "die", "kardiovaskulaeren", "Effekte", "des", "Parathormons", "und", "geht", "insbesondere", "auf", "Veraenderungen", "der", "Struktur", ",", "des", "Tonus", ",", "der", "Distensibilitaet", "grosser", "Arterien", "und", "der", "Endothelfunktion", "ein", "." ]	[ "umlsterm" ]
Risiko, Rolle, Ultraschalltechniken, Parathormon, Dehnbarkeit, Arterien, niereninsuffizienten, Patienten, Parathormonkonzentrationen, Parathormons, Uraemie, Endothel, erkanntes, Parathormons, Patienten, Hyperparathyreoidismus, Parathyreoidektomie, blutdrucksteigernden, Parathormons, Arbeit, Parathormons, Arterien, Endothelfunktion	MedizinischeKlinik.00950267.ger.abstr_task2	Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O" ]	Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .	[ "Funktionelle", "Veraenderungen", "der", "arteriellen", "Gefaesswand", "spielen", "fuer", "das", "kardiovaskulaere", "Risiko", "eine", "wichtige", "Rolle", "und", "lassen", "sich", "mittels", "moderner", "Ultraschalltechniken", "nichtinvasiv", "messen", ".", "Neuere", "Studien", "zeigen", ",", "dass", "Parathormon", "eine", "Reihe", "komplexer", "Effekte", "auf", "das", "kardiovaskulaere", "System", "hat", "und", "neben", "Strukturveraenderungen", "der", "Gefaesswand", "insbesondere", "den", "Tonus", "und", "die", "Dehnbarkeit", "grosser", "Arterien", "beeinflusst", ".", "So", "konnte", "gezeigt", "werden", ",", "dass", "bei", "niereninsuffizienten", "Patienten", "erhoehte", "Parathormonkonzentrationen", "mit", "einer", "Verminderung", "der", "arteriellen", "Distensibilitaet", "und", "einer", "Zunahme", "der", "Intima", "-", "Media", "-", "Dicke", "einhergehen", ".", "Ein", "permissiver", "Effekt", "des", "Parathormons", "fuer", "die", "Gefaesswandveraenderungen", "bei", "Uraemie", "wird", "diskutiert", ".", "Das", "Endothel", "ist", "ein", "neu", "erkanntes", "Zielorgan", "des", "Parathormons", ".", "Bei", "Patienten", "mit", "primaeren", "Hyperparathyreoidismus", "wurde", "eine", "endotheliale", "Dysfunktion", "nachgewiesen", ",", "die", "nach", "Parathyreoidektomie", "reversibel", "ist", ".", "Moeglicherweise", "tragen", "die", "Effekte", "auf", "die", "funktionellen", "Gefaesswandeigenschaften", "zur", "blutdrucksteigernden", "Wirkung", "des", "Parathormons", "bei", ".", "Die", "vorliegende", "Arbeit", "gibt", "einen", "Ueberblick", "ueml", ",", "ber", "die", "kardiovaskulaeren", "Effekte", "des", "Parathormons", "und", "geht", "insbesondere", "auf", "Veraenderungen", "der", "Struktur", ",", "des", "Tonus", ",", "der", "Distensibilitaet", "grosser", "Arterien", "und", "der", "Endothelfunktion", "ein", "." ]	[ "umlsterm" ]
Methylenetetrahydrofolate dehydrogenase is a protein, methenyltetrahydrofolate cyclohydrolase is a protein, formyltetrahydrofolate synthetase is a protein, MTHFD1 is a protein	DS.d1010_task0	Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein	[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	[ "Methylenetetrahydrofolate", "dehydrogenase", ")", "methenyltetrahydrofolate", "cyclohydrolase", ")", "formyltetrahydrofolate", "synthetase", "(", "MTHFD1", ")", "is", "a", "trifunctional", "enzyme", "that", "interconverts", "tetrahydrofolate", "(", "THF", ")", "derivatives", "for", "nucleotide", "synthesis", "." ]	[ "protein", "compound" ]
Methylenetetrahydrofolate dehydrogenase is a protein, methenyltetrahydrofolate cyclohydrolase is a protein, formyltetrahydrofolate synthetase is a protein, MTHFD1 is a protein	DS.d1010_task1	Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please typing these entity words according to sentence: Methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, MTHFD1 Options: protein	[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	[ "Methylenetetrahydrofolate", "dehydrogenase", ")", "methenyltetrahydrofolate", "cyclohydrolase", ")", "formyltetrahydrofolate", "synthetase", "(", "MTHFD1", ")", "is", "a", "trifunctional", "enzyme", "that", "interconverts", "tetrahydrofolate", "(", "THF", ")", "derivatives", "for", "nucleotide", "synthesis", "." ]	[ "protein", "compound" ]
Methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, MTHFD1	DS.d1010_task2	Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please extract entity words from the input sentence	[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	[ "Methylenetetrahydrofolate", "dehydrogenase", ")", "methenyltetrahydrofolate", "cyclohydrolase", ")", "formyltetrahydrofolate", "synthetase", "(", "MTHFD1", ")", "is", "a", "trifunctional", "enzyme", "that", "interconverts", "tetrahydrofolate", "(", "THF", ")", "derivatives", "for", "nucleotide", "synthesis", "." ]	[ "protein", "compound" ]
implantations is an umlsterm, silastic is an umlsterm, Complications is an umlsterm, surgery is an umlsterm, amputation is an umlsterm, pain is an umlsterm, single - stem is an umlsterm, double - stem is an umlsterm, time is an umlsterm, operation is an umlsterm, pain is an umlsterm, rheumatoid arthritis is an umlsterm, arthrosis is an umlsterm, disease is an umlsterm, patients is an umlsterm, pain is an umlsterm, arthrosis is an umlsterm	DerOrthopaede.60250332.eng.abstr_task0	Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .	[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]	[ "umlsterm" ]
implantations is an umlsterm, silastic is an umlsterm, Complications is an umlsterm, surgery is an umlsterm, amputation is an umlsterm, pain is an umlsterm, single - stem is an umlsterm, double - stem is an umlsterm, time is an umlsterm, operation is an umlsterm, pain is an umlsterm, rheumatoid arthritis is an umlsterm, arthrosis is an umlsterm, disease is an umlsterm, patients is an umlsterm, pain is an umlsterm, arthrosis is an umlsterm	DerOrthopaede.60250332.eng.abstr_task1	Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please typing these entity words according to sentence: implantations, silastic, Complications, surgery, amputation, pain, single - stem, double - stem, time, operation, pain, rheumatoid arthritis, arthrosis, disease, patients, pain, arthrosis Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .	[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]	[ "umlsterm" ]
implantations, silastic, Complications, surgery, amputation, pain, single - stem, double - stem, time, operation, pain, rheumatoid arthritis, arthrosis, disease, patients, pain, arthrosis	DerOrthopaede.60250332.eng.abstr_task2	Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .	[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]	[ "umlsterm" ]
Arbeit is an umlsterm, Karzinomen is an umlsterm, weiblichen is an umlsterm, Brust is an umlsterm	DerPathologe.70180045.ger.abstr_task0	Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .	[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]	[ "umlsterm" ]
Arbeit is an umlsterm, Karzinomen is an umlsterm, weiblichen is an umlsterm, Brust is an umlsterm	DerPathologe.70180045.ger.abstr_task1	Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please typing these entity words according to sentence: Arbeit, Karzinomen, weiblichen, Brust Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .	[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]	[ "umlsterm" ]
Arbeit, Karzinomen, weiblichen, Brust	DerPathologe.70180045.ger.abstr_task2	Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .	[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]	[ "umlsterm" ]
Streptokinase is a GENE-N, protease - activated receptor-1 is a GENE-Y	10666203_task0	Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.	[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Streptokinase is a GENE-N, protease - activated receptor-1 is a GENE-Y	10666203_task1	Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please typing these entity words according to sentence: Streptokinase, protease - activated receptor-1 Options: GENE-Y, GENE-N	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.	[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Streptokinase, protease - activated receptor-1	10666203_task2	Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.	[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
cytochrome c is a protein, Ca(2 is a compound	DS.d427_task0	Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.	[ "Here", ",", "we", "assessed", "the", "regulation", "of", "pancreatic", "cytochrome", "c", "release", "by", "Ca(2", "+", ")", ",", "mitochondrial", "membrane", "potential", "(", "Delta", "Psi", "m", ")", ",", "and", "reactive", "oxygen", "species", "(", "ROS", ")", ",", "the", "signals", "involved", "in", "acute", "pancreatitis", "." ]	[ "protein", "compound" ]
cytochrome c is a protein, Ca(2 is a compound	DS.d427_task1	Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please typing these entity words according to sentence: cytochrome c, Ca(2 Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.	[ "Here", ",", "we", "assessed", "the", "regulation", "of", "pancreatic", "cytochrome", "c", "release", "by", "Ca(2", "+", ")", ",", "mitochondrial", "membrane", "potential", "(", "Delta", "Psi", "m", ")", ",", "and", "reactive", "oxygen", "species", "(", "ROS", ")", ",", "the", "signals", "involved", "in", "acute", "pancreatitis", "." ]	[ "protein", "compound" ]
cytochrome c, Ca(2	DS.d427_task2	Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.	[ "Here", ",", "we", "assessed", "the", "regulation", "of", "pancreatic", "cytochrome", "c", "release", "by", "Ca(2", "+", ")", ",", "mitochondrial", "membrane", "potential", "(", "Delta", "Psi", "m", ")", ",", "and", "reactive", "oxygen", "species", "(", "ROS", ")", ",", "the", "signals", "involved", "in", "acute", "pancreatitis", "." ]	[ "protein", "compound" ]
IL-12 is a Entity, IFN regulating factor-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, CD4 is a Protein, IL-12 is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, MIP-1alpha is a Protein, MIP-1beta is a Protein, IL-1RA is a Protein, IFN regulatory factor-1 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IFN - gamma is a Protein, IL-2 is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, promoter is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-4 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IL-12 is a Entity	218_task0	Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "B-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.	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IL-12 is a Entity, IFN regulating factor-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, CD4 is a Protein, IL-12 is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, MIP-1alpha is a Protein, MIP-1beta is a Protein, IL-1RA is a Protein, IFN regulatory factor-1 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IFN - gamma is a Protein, IL-2 is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, promoter is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-4 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IL-12 is a Entity	218_task1	Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please typing these entity words according to sentence: IL-12, IFN regulating factor-1, IRF-1, IL-12, CD4, IL-12, IL-12, genes, IL-12, genes, IL-12, MIP-1alpha, MIP-1beta, IL-1RA, IFN regulatory factor-1, IRF-1, IRF-1, IL-12, IRF-1, IL-12, IRF-1, IFN - gamma, IL-2, IL-12, IRF-1, IL-12, STAT4, IRF-1, STAT4, IRF-1, STAT4, IRF-1, promoter, IL-12, IRF-1, IL-4, IRF-1, IRF-1, IL-12, IL-12 Options: Entity, Protein	[ "B-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.	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IL-12, IFN regulating factor-1, IRF-1, IL-12, CD4, IL-12, IL-12, genes, IL-12, genes, IL-12, MIP-1alpha, MIP-1beta, IL-1RA, IFN regulatory factor-1, IRF-1, IRF-1, IL-12, IRF-1, IL-12, IRF-1, IFN - gamma, IL-2, IL-12, IRF-1, IL-12, STAT4, IRF-1, STAT4, IRF-1, STAT4, IRF-1, promoter, IL-12, IRF-1, IL-4, IRF-1, IRF-1, IL-12, IL-12	218_task2	Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please extract entity words from the input sentence	[ "B-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Entity", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.	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Patienten is an umlsterm, Fistel is an umlsterm, Duodenum is an umlsterm, Diagnose is an umlsterm, Endoskopie is an umlsterm, Computertomographie is an umlsterm, Fistelsanierung is an umlsterm, Prothesenmaterials is an umlsterm, Duodenalverschluss is an umlsterm, Diagnostik is an umlsterm, Therapieverfahren is an umlsterm	Gefaesschirurgie.70020126.ger.abstr_task0	Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .	[ "Die", "vorliegende", "Kasuistik", "schildert", "den", "Fall", "eines", "52jaehrigen", "Patienten", ",", "der", "33", "Monate", "nach", "Implantation", "einer", "Aortenrohrprothese", "eine", "sekundaere", "aortoenterale", "Fistel", "Typ", "2", "zum", "Duodenum", "entwickelte", ".", "Die", "praeoperative", "Diagnose", "wurde", "durch", "eine", "obere", "Endoskopie", "und", "eine", "abdominelle", "Computertomographie", "gestellt", ".", "Die", "Fistelsanierung", "erfolgte", "durch", "eine", "In", "-", "situ", "-", "Rekonstruktion", "mit", "Omentumplastik", "nach", "Entfernung", "des", "alten", "Prothesenmaterials", "und", "Duodenalverschluss", ".", "Es", "werden", "die", "Wertigkeit", "der", "praeoperativen", "Diagnostik", "und", "die", "2", "alternativen", "operativen", "Therapieverfahren", ",", "die", "In", "-", "situ", "-", "Rekonstruktion", "und", "die", "extra", "-", "anatomische", "Revaskularisation", "diskutiert", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Fistel is an umlsterm, Duodenum is an umlsterm, Diagnose is an umlsterm, Endoskopie is an umlsterm, Computertomographie is an umlsterm, Fistelsanierung is an umlsterm, Prothesenmaterials is an umlsterm, Duodenalverschluss is an umlsterm, Diagnostik is an umlsterm, Therapieverfahren is an umlsterm	Gefaesschirurgie.70020126.ger.abstr_task1	Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please typing these entity words according to sentence: Patienten, Fistel, Duodenum, Diagnose, Endoskopie, Computertomographie, Fistelsanierung, Prothesenmaterials, Duodenalverschluss, Diagnostik, Therapieverfahren Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .	[ "Die", "vorliegende", "Kasuistik", "schildert", "den", "Fall", "eines", "52jaehrigen", "Patienten", ",", "der", "33", "Monate", "nach", "Implantation", "einer", "Aortenrohrprothese", "eine", "sekundaere", "aortoenterale", "Fistel", "Typ", "2", "zum", "Duodenum", "entwickelte", ".", "Die", "praeoperative", "Diagnose", "wurde", "durch", "eine", "obere", "Endoskopie", "und", "eine", "abdominelle", "Computertomographie", "gestellt", ".", "Die", "Fistelsanierung", "erfolgte", "durch", "eine", "In", "-", "situ", "-", "Rekonstruktion", "mit", "Omentumplastik", "nach", "Entfernung", "des", "alten", "Prothesenmaterials", "und", "Duodenalverschluss", ".", "Es", "werden", "die", "Wertigkeit", "der", "praeoperativen", "Diagnostik", "und", "die", "2", "alternativen", "operativen", "Therapieverfahren", ",", "die", "In", "-", "situ", "-", "Rekonstruktion", "und", "die", "extra", "-", "anatomische", "Revaskularisation", "diskutiert", "." ]	[ "umlsterm" ]
Patienten, Fistel, Duodenum, Diagnose, Endoskopie, Computertomographie, Fistelsanierung, Prothesenmaterials, Duodenalverschluss, Diagnostik, Therapieverfahren	Gefaesschirurgie.70020126.ger.abstr_task2	Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .	[ "Die", "vorliegende", "Kasuistik", "schildert", "den", "Fall", "eines", "52jaehrigen", "Patienten", ",", "der", "33", "Monate", "nach", "Implantation", "einer", "Aortenrohrprothese", "eine", "sekundaere", "aortoenterale", "Fistel", "Typ", "2", "zum", "Duodenum", "entwickelte", ".", "Die", "praeoperative", "Diagnose", "wurde", "durch", "eine", "obere", "Endoskopie", "und", "eine", "abdominelle", "Computertomographie", "gestellt", ".", "Die", "Fistelsanierung", "erfolgte", "durch", "eine", "In", "-", "situ", "-", "Rekonstruktion", "mit", "Omentumplastik", "nach", "Entfernung", "des", "alten", "Prothesenmaterials", "und", "Duodenalverschluss", ".", "Es", "werden", "die", "Wertigkeit", "der", "praeoperativen", "Diagnostik", "und", "die", "2", "alternativen", "operativen", "Therapieverfahren", ",", "die", "In", "-", "situ", "-", "Rekonstruktion", "und", "die", "extra", "-", "anatomische", "Revaskularisation", "diskutiert", "." ]	[ "umlsterm" ]
tumor necrosis factor alpha is a Protein, TNF- alpha is a Protein, TNF - alpha is a Protein	733_task0	Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.	[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]	[ "Protein" ]
tumor necrosis factor alpha is a Protein, TNF- alpha is a Protein, TNF - alpha is a Protein	733_task1	Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please typing these entity words according to sentence: tumor necrosis factor alpha, TNF- alpha, TNF - alpha Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.	[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]	[ "Protein" ]
tumor necrosis factor alpha, TNF- alpha, TNF - alpha	733_task2	Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.	[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]	[ "Protein" ]
Langzeiteffekt is an umlsterm, DNase is an umlsterm, Patienten is an umlsterm, Mukoviszidose is an umlsterm	MonatsschriftKinderheilkunde.91470573.ger.abstr_task0	Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .	[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]	[ "umlsterm" ]
Langzeiteffekt is an umlsterm, DNase is an umlsterm, Patienten is an umlsterm, Mukoviszidose is an umlsterm	MonatsschriftKinderheilkunde.91470573.ger.abstr_task1	Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please typing these entity words according to sentence: Langzeiteffekt, DNase, Patienten, Mukoviszidose Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .	[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]	[ "umlsterm" ]
Langzeiteffekt, DNase, Patienten, Mukoviszidose	MonatsschriftKinderheilkunde.91470573.ger.abstr_task2	Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .	[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]	[ "umlsterm" ]
Imidazo- and 2-Methylimidazo[2,1-b]thiazole is a CHEMICAL, Ghrelin Receptor is a GENE-Y	23610086_task0	Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]	Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.	[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]	[ "CHEMICAL", "GENE-Y" ]
Imidazo- and 2-Methylimidazo[2,1-b]thiazole is a CHEMICAL, Ghrelin Receptor is a GENE-Y	23610086_task1	Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please typing these entity words according to sentence: Imidazo- and 2-Methylimidazo[2,1-b]thiazole, Ghrelin Receptor Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]	Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.	[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]	[ "CHEMICAL", "GENE-Y" ]
Imidazo- and 2-Methylimidazo[2,1-b]thiazole, Ghrelin Receptor	23610086_task2	Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]	Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.	[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]	[ "CHEMICAL", "GENE-Y" ]
IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, NF - kappa B - like sequence is a Entity, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-8 is a Protein, IL-8 is a Protein	494_task0	Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.	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IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, NF - kappa B - like sequence is a Entity, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-8 is a Protein, IL-8 is a Protein	494_task1	Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please typing these entity words according to sentence: IL-8, CD28, IL-8, CD28, IL-8, CD28, IL-8, CD28, NF - kappa B - like sequence, IL-8, CD28, IL-8, CD28, CD28, IL-8, IL-8 Options: Entity, Protein	[ "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.	[ "Induction", "of", "IL-8", "expression", "in", "T", "cells", "uses", "the", "CD28", "costimulatory", "pathway", ".", "\n", "IL-8", ",", "a", "potent", "chemotactic", "factor", "for", "neutrophil", "granulocytes", "and", "lymphocytes", ",", "is", "a", "proinflammatory", "cytokine", "secreted", "by", "a", "variety", "of", "cell", "types", ",", "including", "T", "cells", ".", "Stimulation", "of", "the", "CD28", "cell", "surface", "molecule", "delivers", "costimulatory", "signals", "essential", "for", "lymphokine", "production", "in", "activated", "T", "cells", "via", "a", "conserved", "sequence", "element", "found", "in", "the", "promoter", "of", "several", "lymphokine", "genes", ".", "Anti", "-", "CD28-stimulated", "T", "cells", "produced", "significant", "amounts", "of", "IL-8", ";", "additionally", ",", "costimulation", "with", "anti", "-", "CD3", "and", "anti", "-", "CD28", "Abs", "resulted", "in", "a", "synergistic", "induction", "of", "IL-8", "secretion", ".", "Sequence", "homology", ",", "single", "nucleotide", "mutations", ",", "and", "anti", "-", "CD28", "Ab", "stimulation", "studies", "established", "that", "the", "NF", "-", "kappa", "B", "-", "like", "sequence", "in", "the", "promoter", "of", "the", "IL-8", "gene", "functioned", "as", "a", "CD28", "response", "element", ".", "Furthermore", ",", "cyclosporin", "A", ",", "but", "not", "rapamycin", ",", "blocked", "the", "synergistic", "induction", "of", "IL-8", "expression", "achieved", "with", "anti", "-", "CD3", "and", "anti", "-", "CD28", "costimulation", ".", "The", "involvement", "of", "a", "CD28", "response", "element", "in", "the", "induction", "of", "IL-8", "expression", "in", "activated", "T", "cells", "may", "provide", "new", "insights", "into", "the", "pathogenesis", "and", "persistence", "of", "immune", "disorders", "characterized", "by", "increased", "levels", "of", "IL-8", ",", "such", "as", "psoriasis", "and", "rheumatoid", "arthritis", "." ]	[ "Entity", "Protein" ]
IL-8, CD28, IL-8, CD28, IL-8, CD28, IL-8, CD28, NF - kappa B - like sequence, IL-8, CD28, IL-8, CD28, CD28, IL-8, IL-8	494_task2	Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.	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N - acetylcysteine inhibition is an other_name, cytokine - induced E - selectin is a protein_molecule, VCAM-1 expression is an other_name	59018_task0	Sentence: Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_molecule, other_name	[ "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-other_name", "I-other_name", "O" ]	Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.	[ "Distinct", "mechanisms", "for", "N", "-", "acetylcysteine", "inhibition", "of", "cytokine", "-", "induced", "E", "-", "selectin", "and", "VCAM-1", "expression", "." ]	[ "other_name", "protein_molecule", "DNA_domain_or_region", "other_organic_compound", "DNA_molecule", "(OR RNA_molecule RNA_molecule)", "RNA_family_or_group", "protein_complex", "DNA_family_or_group", "amino_acid_monomer", "peptide", "lipid", "cell_type", "" ]
N - acetylcysteine inhibition is an other_name, cytokine - induced E - selectin is a protein_molecule, VCAM-1 expression is an other_name	59018_task1	Sentence: Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Instructions: please typing these entity words according to sentence: N - acetylcysteine inhibition, cytokine - induced E - selectin, VCAM-1 expression Options: protein_molecule, other_name	[ "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-other_name", "I-other_name", "O" ]	Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.	[ "Distinct", "mechanisms", "for", "N", "-", "acetylcysteine", "inhibition", "of", "cytokine", "-", "induced", "E", "-", "selectin", "and", "VCAM-1", "expression", "." ]	[ "other_name", "protein_molecule", "DNA_domain_or_region", "other_organic_compound", "DNA_molecule", "(OR RNA_molecule RNA_molecule)", "RNA_family_or_group", "protein_complex", "DNA_family_or_group", "amino_acid_monomer", "peptide", "lipid", "cell_type", "" ]

femoral nerves is an umlsterm, invasive procedures is an umlsterm, knee is an umlsterm, ankle joint is an umlsterm, flexibility is an umlsterm, anaesthetist 's is an umlsterm, schedule is an umlsterm, relaxation is an umlsterm, muscles is an umlsterm, contraindications is an umlsterm, arrhythmia is an umlsterm, heart is an umlsterm, lidocaine is an umlsterm, mepivacaine is an umlsterm, sciatic nerve is an umlsterm, femoral nerve is an umlsterm, book is an umlsterm, patient is an umlsterm, complications is an umlsterm, operation is an umlsterm, pain is an umlsterm

Arthroskopie.80110102.eng.abstr_task1

Sentence: Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty . Instructions: please typing these entity words according to sentence: femoral nerves, invasive procedures, knee, ankle joint, flexibility, anaesthetist 's, schedule, relaxation, muscles, contraindications, arrhythmia, heart, lidocaine, mepivacaine, sciatic nerve, femoral nerve, book, patient, complications, operation, pain Options: umlsterm

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Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty .

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[ "umlsterm" ]

femoral nerves, invasive procedures, knee, ankle joint, flexibility, anaesthetist 's, schedule, relaxation, muscles, contraindications, arrhythmia, heart, lidocaine, mepivacaine, sciatic nerve, femoral nerve, book, patient, complications, operation, pain

Arthroskopie.80110102.eng.abstr_task2

Sentence: Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty . Instructions: please extract entity words from the input sentence

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Block of the sciatic and femoral nerves can be performed either by the surgeon or by the anaesthetist , allowing for numerous minimally invasive procedures in the knee and ankle joint . It also offers a certain flexibility with regard to the anaesthetist's schedule and provides a good and long anaesthesia and relaxation of the quadricep and hamstring muscles . Some contraindications - arrhythmia , severe conduction disturbance and heart failure - should be considered , as well as vegetative lability and oversensitivity to xylocaine , lidocaine or mepivacaine . There is no difficulty in finding the sciatic nerve and the femoral nerve as the topography is well described by Daniel C. Moore in his book about regional block . Though easy to perform , and even when wished for by the patient , the surgeon has to be aware of possible complications . In some cases we recommend that an anaesthesiologist stand by . In only 2 of 720 cases did the operation have to be interrupted because of severe pain or unexpected difficulty .

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[ "umlsterm" ]

wachsende is an umlsterm, gezielt is an umlsterm, Elementen is an umlsterm

Psychotherapeut.60410088.ger.abstr_task0

Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .

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[ "umlsterm" ]

wachsende is an umlsterm, gezielt is an umlsterm, Elementen is an umlsterm

Psychotherapeut.60410088.ger.abstr_task1

Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please typing these entity words according to sentence: wachsende, gezielt, Elementen Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .

[ "Es", "wird", "der", "Versuch", "unternommen", ",", "dass", "klassische", "Konzept", "der", "Konversion", "unter", "Einbeziehung", "psychodynamischer", "Auffassungen", "zu", "operationalisieren", ".", "Im", "Hintergrund", "steht", "die", "wachsende", "Evidenz", ",", "dass", "Konversionsvorgaenge", "ueber", "die", "hysterische", "Psychodynamik", "weit", "hinausreichen", ".", "Der", "Operationalisierungsentwurf", "ist", "restriktiv", "entworfen", ",", "um", "gezielt", "die", "profuse", "Ausweitung", "und", "damit", "Entwertung", "des", "Konzepts", "zu", "verhindern", ".", "Der", "Operationalisierungsvorgang", "wird", "in", "drei", "Schritten", "nachvollziehbar", "gemacht", ".", "Ausgehend", "von", "einer", "Konsensusdefinition", "wird", "ueber", "die", "Darstellung", "von", "11", "dynamischen", "Elementen", "des", "Konversionskonstrukts", "versucht", ",", "seine", "Komplexitaet", "herabzusetzen", ",", "um", "dann", "in", "die", "eigentliche", "Operationalisierung", "ueberzuleiten", "." ]

[ "umlsterm" ]

wachsende, gezielt, Elementen

Psychotherapeut.60410088.ger.abstr_task2

Sentence: Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird der Versuch unternommen , dass klassische Konzept der Konversion unter Einbeziehung psychodynamischer Auffassungen zu operationalisieren . Im Hintergrund steht die wachsende Evidenz , dass Konversionsvorgaenge ueber die hysterische Psychodynamik weit hinausreichen . Der Operationalisierungsentwurf ist restriktiv entworfen , um gezielt die profuse Ausweitung und damit Entwertung des Konzepts zu verhindern . Der Operationalisierungsvorgang wird in drei Schritten nachvollziehbar gemacht . Ausgehend von einer Konsensusdefinition wird ueber die Darstellung von 11 dynamischen Elementen des Konversionskonstrukts versucht , seine Komplexitaet herabzusetzen , um dann in die eigentliche Operationalisierung ueberzuleiten .

[ "Es", "wird", "der", "Versuch", "unternommen", ",", "dass", "klassische", "Konzept", "der", "Konversion", "unter", "Einbeziehung", "psychodynamischer", "Auffassungen", "zu", "operationalisieren", ".", "Im", "Hintergrund", "steht", "die", "wachsende", "Evidenz", ",", "dass", "Konversionsvorgaenge", "ueber", "die", "hysterische", "Psychodynamik", "weit", "hinausreichen", ".", "Der", "Operationalisierungsentwurf", "ist", "restriktiv", "entworfen", ",", "um", "gezielt", "die", "profuse", "Ausweitung", "und", "damit", "Entwertung", "des", "Konzepts", "zu", "verhindern", ".", "Der", "Operationalisierungsvorgang", "wird", "in", "drei", "Schritten", "nachvollziehbar", "gemacht", ".", "Ausgehend", "von", "einer", "Konsensusdefinition", "wird", "ueber", "die", "Darstellung", "von", "11", "dynamischen", "Elementen", "des", "Konversionskonstrukts", "versucht", ",", "seine", "Komplexitaet", "herabzusetzen", ",", "um", "dann", "in", "die", "eigentliche", "Operationalisierung", "ueberzuleiten", "." ]

[ "umlsterm" ]

MHC class II expression is an other_name, human class II trans - activator constructs is a DNA_family_or_group, N - terminal domain is a protein_domain_or_region

56366_task0

Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, protein_domain_or_region, other_name

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.

[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]

[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]

MHC class II expression is an other_name, human class II trans - activator constructs is a DNA_family_or_group, N - terminal domain is a protein_domain_or_region

56366_task1

Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please typing these entity words according to sentence: MHC class II expression, human class II trans - activator constructs, N - terminal domain Options: DNA_family_or_group, protein_domain_or_region, other_name

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.

[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]

[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]

MHC class II expression, human class II trans - activator constructs, N - terminal domain

56366_task2

Sentence: Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "I-DNA_family_or_group", "O", "O", "B-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "I-protein_domain_or_region", "O" ]

Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.

[ "Suppression", "of", "MHC", "class", "II", "expression", "by", "human", "class", "II", "trans", "-", "activator", "constructs", "lacking", "the", "N", "-", "terminal", "domain", "." ]

[ "DNA_family_or_group", "protein_family_or_group", "protein_domain_or_region", "other_name", "protein_molecule", "RNA_molecule", "cell_line", "amino_acid_monomer" ]

JunB is a Protein, FosB is a Protein, c - Fos is a Protein, immunoglobulin - like transcript-2 is a Protein, leukocyte Ig - like receptor 1 is a Protein, HLA - B27 is a Protein, JunB is a Protein, FosB is a Protein, c - Fos is a Protein

10201929_task0

Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.

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[ "Protein" ]

JunB is a Protein, FosB is a Protein, c - Fos is a Protein, immunoglobulin - like transcript-2 is a Protein, leukocyte Ig - like receptor 1 is a Protein, HLA - B27 is a Protein, JunB is a Protein, FosB is a Protein, c - Fos is a Protein

10201929_task1

Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please typing these entity words according to sentence: JunB, FosB, c - Fos, immunoglobulin - like transcript-2, leukocyte Ig - like receptor 1, HLA - B27, JunB, FosB, c - Fos Options: Protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.

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[ "Protein" ]

JunB, FosB, c - Fos, immunoglobulin - like transcript-2, leukocyte Ig - like receptor 1, HLA - B27, JunB, FosB, c - Fos

10201929_task2

Sentence: Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.

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[ "Protein" ]

singleton pregnancy is a Condition, cesarean section is a Procedure, after 37 weeks is a Value, gestation is a Measurement

NCT02277041_inc_task0

Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Procedure, Measurement, Value

[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]

Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.

[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]

[ "Condition", "Procedure", "Value", "Measurement" ]

singleton pregnancy is a Condition, cesarean section is a Procedure, after 37 weeks is a Value, gestation is a Measurement

NCT02277041_inc_task1

Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please typing these entity words according to sentence: singleton pregnancy, cesarean section, after 37 weeks, gestation Options: Condition, Procedure, Measurement, Value

[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]

Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.

[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]

[ "Condition", "Procedure", "Value", "Measurement" ]

singleton pregnancy, cesarean section, after 37 weeks, gestation

NCT02277041_inc_task2

Sentence: Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "O", "O" ]

Women with a singleton pregnancy undergoing cesarean section after 37 weeks of gestation.

[ "Women", "with", "a", "singleton", "pregnancy", "undergoing", "cesarean", "section", "after", "37", "weeks", "of", "gestation", ".", "\n" ]

[ "Condition", "Procedure", "Value", "Measurement" ]

Synaptotagmin I is a protein, polymerized tubulin is a protein

1.0alpha7.train.823_task0

Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein

[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]

Synaptotagmin I also binds to polymerized tubulin.

[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]

[ "protein", "protein-family" ]

Synaptotagmin I is a protein, polymerized tubulin is a protein

1.0alpha7.train.823_task1

Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please typing these entity words according to sentence: Synaptotagmin I, polymerized tubulin Options: protein

[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]

Synaptotagmin I also binds to polymerized tubulin.

[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]

[ "protein", "protein-family" ]

Synaptotagmin I, polymerized tubulin

1.0alpha7.train.823_task2

Sentence: Synaptotagmin I also binds to polymerized tubulin. Instructions: please extract entity words from the input sentence

[ "B-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "O" ]

Synaptotagmin I also binds to polymerized tubulin.

[ "Synaptotagmin", "I", "also", "binds", "to", "polymerized", "tubulin", "." ]

[ "protein", "protein-family" ]

CYP2E1 is a GENE-Y, CYP2B4 is a GENE-Y, NADPH - cytochrome P450 reductase is a GENE-Y

23043184_task0

Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

CYP2E1 is a GENE-Y, CYP2B4 is a GENE-Y, NADPH - cytochrome P450 reductase is a GENE-Y

23043184_task1

Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please typing these entity words according to sentence: CYP2E1, CYP2B4, NADPH - cytochrome P450 reductase Options: GENE-Y

[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

CYP2E1, CYP2B4, NADPH - cytochrome P450 reductase

23043184_task2

Sentence: Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

[ "Interactions", "between", "CYP2E1", "and", "CYP2B4", ":", "effects", "on", "affinity", "for", "NADPH", "-", "cytochrome", "P450", "reductase", "and", "substrate", "metabolism", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole is a CHEMICAL, A-381393 is a CHEMICAL, dopamine D4 receptor is a GENE-Y

15992586_task0

Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.

[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole is a CHEMICAL, A-381393 is a CHEMICAL, dopamine D4 receptor is a GENE-Y

15992586_task1

Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please typing these entity words according to sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole, A-381393, dopamine D4 receptor Options: GENE-Y, CHEMICAL

[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.

[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole, A-381393, dopamine D4 receptor

15992586_task2

Sentence: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O" ]

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.

[ "2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H", "benzoimidazole", "(", "A-381393", ")", ",", "a", "selective", "dopamine", "D4", "receptor", "antagonist", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

visceral fat gain is a Outcome_Physical, endothelial dysfunction is a Outcome_Physical, endothelial function is a Outcome_Physical, Endothelial dysfunction is a Outcome_Physical, gain weight is a Intervention_Physical, maintain weight is a Intervention_Control, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ) is a Outcome_Physical, total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography is a Outcome_Physical, subcutaneous fat gain is a Outcome_Physical, blood pressure is a Outcome_Physical

47051_task0

Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Intervention_Control

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Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .

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[ "Outcome_Physical", "Intervention_Control", "Intervention_Physical" ]

visceral fat gain is a Outcome_Physical, endothelial dysfunction is a Outcome_Physical, endothelial function is a Outcome_Physical, Endothelial dysfunction is a Outcome_Physical, gain weight is a Intervention_Physical, maintain weight is a Intervention_Control, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ) is a Outcome_Physical, total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography is a Outcome_Physical, subcutaneous fat gain is a Outcome_Physical, blood pressure is a Outcome_Physical

47051_task1

Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . Instructions: please typing these entity words according to sentence: visceral fat gain, endothelial dysfunction, endothelial function, Endothelial dysfunction, gain weight, maintain weight, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ), total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography, subcutaneous fat gain, blood pressure Options: Intervention_Physical, Outcome_Physical, Intervention_Control

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Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .

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[ "Outcome_Physical", "Intervention_Control", "Intervention_Physical" ]

visceral fat gain, endothelial dysfunction, endothelial function, Endothelial dysfunction, gain weight, maintain weight, Endothelial function ( brachial artery flow - mediated dilation [ FMD ] ), total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography, subcutaneous fat gain, blood pressure

47051_task2

Sentence: Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) . Instructions: please extract entity words from the input sentence

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Modest visceral fat gain causes endothelial dysfunction in healthy humans . OBJECTIVES The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans . BACKGROUND Endothelial dysfunction has been identified as an independent predictor of cardiovascular events . Whether fat gain impairs endothelial function is unknown . METHODS A randomized controlled study was conducted to assess the effects of fat gain on endothelial function . Forty-three normal-weight healthy volunteers were recruited ( mean age 29 years ; 18 women ) . Subjects were assigned to gain weight ( approximately 4 kg ) ( n=35 ) or to maintain weight ( n=8 ) . Endothelial function ( brachial artery flow-mediated dilation [ FMD ] ) was measured at baseline , after fat gain ( 8 weeks ) , and after weight loss ( 16 weeks ) for fat gainers and at baseline and follow-up ( 8 weeks ) for weight maintainers . Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans . RESULTS After an average weight gain of 4.1 kg , fat gainers significantly increased their total , visceral , and subcutaneous fat . Blood pressure and overnight polysomnography did not change after fat gain or loss . FMD remained unchanged in weight maintainers . FMD decreased in fat gainers ( 9.1+/-3 % vs. 7.8+/-3.2 % , p=0.003 ) but recovered to baseline when subjects shed the gained weight . There was a significant correlation between the decrease in FMD and the increase in visceral fat gain ( rho=-0.42 , p=0.004 ) , but not with subcutaneous fat gain ( rho=-0.22 , p=0.15 ) . CONCLUSIONS In normal-weight healthy young subjects , modest fat gain results in impaired endothelial function , even in the absence of changes in blood pressure . Endothelial function recovers after weight loss . Increased visceral rather than subcutaneous fat predicts endothelial dysfunction . ( Fat Gain and Cardiovascular Disease Mechanisms ; NCT00589498 ) .

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[ "Outcome_Physical", "Intervention_Control", "Intervention_Physical" ]

Patient navigation is a Intervention_Educational, diagnostic resolution is a Outcome_Other, underserved population . is a Participant_Condition, low - income , uninsured , and minority populations . is a Participant_Condition, lay patient navigators is a Intervention_Educational, no - navigation ( control ) is a Intervention_Control, colorectal is a Outcome_Other, Time to resolution is a Outcome_Other, prostate screening resolution is a Outcome_Other, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . is a Participant_Condition

56785_task0

Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Outcome_Other, Intervention_Control, Participant_Condition

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Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Control", "Intervention_Educational" ]

Patient navigation is a Intervention_Educational, diagnostic resolution is a Outcome_Other, underserved population . is a Participant_Condition, low - income , uninsured , and minority populations . is a Participant_Condition, lay patient navigators is a Intervention_Educational, no - navigation ( control ) is a Intervention_Control, colorectal is a Outcome_Other, Time to resolution is a Outcome_Other, prostate screening resolution is a Outcome_Other, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . is a Participant_Condition

56785_task1

Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please typing these entity words according to sentence: Patient navigation, diagnostic resolution, underserved population ., low - income , uninsured , and minority populations ., lay patient navigators, no - navigation ( control ), colorectal, Time to resolution, prostate screening resolution, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . Options: Intervention_Educational, Outcome_Other, Intervention_Control, Participant_Condition

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Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Control", "Intervention_Educational" ]

Patient navigation, diagnostic resolution, underserved population ., low - income , uninsured , and minority populations ., lay patient navigators, no - navigation ( control ), colorectal, Time to resolution, prostate screening resolution, Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured .

56785_task2

Sentence: Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes . Instructions: please extract entity words from the input sentence

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Patient navigation improves cancer diagnostic resolution : an individually randomized clinical trial in an underserved population . BACKGROUND Barriers to timely resolution of abnormal cancer screening tests add to cancer health disparities among low-income , uninsured , and minority populations . We conducted a randomized trial to evaluate the impact of lay patient navigators on time to resolution and completion of follow-up testing among patients with abnormal screening tests in a medically underserved patient population . METHODS Denver Health , the safety-net health care system serving Denver , is one of 10 performance sites participating in the Patient Navigation Research Program . Of 993 eligible subjects with abnormal screening tests randomized to navigation and no-navigation ( control ) arms and analyzed , 628 had abnormal breast screens ( 66 abnormal clinical breast examinations , 304 BIRADS 0 , 200 BIRADS 3 , 58 BIRADS 4 or 5 ) whereas 235 had abnormal colorectal and 130 had abnormal prostate screens . RESULTS Time to resolution was significantly shorter in the navigated group ( stratified log rank test , P < 0.001 ) . Patient navigation improved diagnostic resolution for patients presenting with mammographic BIRADS 3 ( P = 0.0003 ) and BIRADS 0 ( P = 0.09 ) , but not BIRADS 4/5 or abnormal breast examinations . Navigation shortened the time for both colorectal ( P = 0.0017 ) and prostate screening resolution ( P = 0.06 ) . Participant demographics included 72 % minority , 49 % with annual household income less than $ 10,000 , and 36 % uninsured . CONCLUSIONS Patient navigation positively impacts time to resolution of abnormal screening tests for breast , colorectal , and prostate cancers in a medically underserved population . IMPACT By shortening the time to and increasing the proportion of patients with diagnostic resolution patient navigation could reduce disparities in stage at diagnosis and improve cancer outcomes .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Control", "Intervention_Educational" ]

Rolle is an umlsterm, Skelettmetastasen is an umlsterm, gezielten is an umlsterm, Metastasensuche is an umlsterm

DerRadiologe.00400826.ger.abstr_task0

Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .

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[ "umlsterm" ]

Rolle is an umlsterm, Skelettmetastasen is an umlsterm, gezielten is an umlsterm, Metastasensuche is an umlsterm

DerRadiologe.00400826.ger.abstr_task1

Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please typing these entity words according to sentence: Rolle, Skelettmetastasen, gezielten, Metastasensuche Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]

Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .

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[ "umlsterm" ]

Rolle, Skelettmetastasen, gezielten, Metastasensuche

DerRadiologe.00400826.ger.abstr_task2

Sentence: Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden . Instructions: please extract entity words from the input sentence

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Die MRT spielt eine bedeutende Rolle bei der diagnostischen Abklaerung von Skelettmetastasen . Prinzipiell kann man dabei 2 Anwendungsbereiche der MRT unterscheiden : Neben dem gelaeufigen Einsatz zur Abklaerung unklarer Befunde oder der gezielten hochaufloesenden Darstellung ossaerer Laesionen kann die MRT auch als primaeres Screeningverfahren zur Metastasensuche eingesetzt werden .

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[ "umlsterm" ]

Env is a Protein, gp120 is a Protein, env is a Protein, Env is a Protein, Env is a Protein, CD4 is a Protein, env is a Protein

183_task0

Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.

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[ "Protein" ]

Env is a Protein, gp120 is a Protein, env is a Protein, Env is a Protein, Env is a Protein, CD4 is a Protein, env is a Protein

183_task1

Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please typing these entity words according to sentence: Env, gp120, env, Env, Env, CD4, env Options: Protein

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Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.

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[ "Protein" ]

Env, gp120, env, Env, Env, CD4, env

183_task2

Sentence: Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated. Instructions: please extract entity words from the input sentence

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Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques. We have analyzed changes to proviral Env gp120 sequences and the development of neutralizing antibodies (NAbs) during 1 year of simian/human immunodeficiency virus SHIV-89.6P infection in 11 Macaca nemestrina macaques. Seven macaques had significant env divergence from that of the inoculum, and macaques with greater divergence had higher titers of homologous NAbs. Substitutions in sequons encoding potential N-linked glycosylation sites (PNGs) were among the first to be established, although overall the total number of sequons did not increase significantly. The majority (19 of 23) of PNGs present in the inoculum were conserved in the sequences from all macaques. Statistically significant variations in PNGs occurred in multiple macaques within constrained regions we term "hot spots," resulting in the selection of sequences more similar to the B consensus. These included additions on V1, the N-terminal side of V4, and the outer region of C2. Complex mutational patterns resulted in convergent PNG shifts in V2 and V5. Charge changes in Env V1V2, resulting in a net acidic charge, and a proline addition in V5 occurred in several macaques. Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site. Nonsynonymous-to-synonymous substitution ratios suggest that these changes result from selective pressure. This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.

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[ "Protein" ]

Psychosen is an umlsterm, Beobachtung is an umlsterm, Arbeit is an umlsterm, Pole is an umlsterm, Achsensyndrome is an umlsterm, Achsensyndrome is an umlsterm, Aufbauelemente is an umlsterm, Affektausdruck is an umlsterm, Affekt is an umlsterm, Denkens is an umlsterm

DerNervenarzt.80690228.ger.abstr_task0

Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .

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[ "umlsterm" ]

Psychosen is an umlsterm, Beobachtung is an umlsterm, Arbeit is an umlsterm, Pole is an umlsterm, Achsensyndrome is an umlsterm, Achsensyndrome is an umlsterm, Aufbauelemente is an umlsterm, Affektausdruck is an umlsterm, Affekt is an umlsterm, Denkens is an umlsterm

DerNervenarzt.80690228.ger.abstr_task1

Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please typing these entity words according to sentence: Psychosen, Beobachtung, Arbeit, Pole, Achsensyndrome, Achsensyndrome, Aufbauelemente, Affektausdruck, Affekt, Denkens Options: umlsterm

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Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .

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[ "umlsterm" ]

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DerNervenarzt.80690228.ger.abstr_task2

Sentence: Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten . Instructions: please extract entity words from the input sentence

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Der Begriff " zykloide Psychosen " bezeichnet eine zunaechst nach dem Erscheinungsbild abzugrenzende Art innerhalb der Gattung " schizophrener Formenkreis " . Ausgehend von der klinischen Beobachtung wird in der vorliegenden phaenomenologisch-konzeptuellen Arbeit die Auffassung vertreten , dass die Leonhardschen Subtypen bzw. deren jeweilige Pole als Achsensyndrome zu begreifen sind , die waehrend ein und derselben Episode gemeinsam auftreten und ineinander uebergehen koennen . Die inneren " Zusammenhaenge " dieser Achsensyndrome werden herausgearbeitet . Neben dem kongruenten Verweisungscharakter ihrer Aufbauelemente erweist sich dabei das Fehlen struktureller Verformungen 1. von Affektausdruck und Affekt , 2. des Denkens und 3. der Bewegungsimpulse und -ablaeufe als entscheidende Differentia specifica gegenueber einer schizophrenen Kerngruppe . Unseren praezisierten Phaenomenbegriff machen wir zur Grundlage einer Kritik bisheriger Operationalisierungsvorschlaege , fuer die wir eine Alternative anbieten .

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[ "umlsterm" ]

1,25-dihydroxyvitamin D is a compound, VDR is a protein

DS.d1597_task0

Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.

[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]

[ "compound", "protein" ]

1,25-dihydroxyvitamin D is a compound, VDR is a protein

DS.d1597_task1

Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please typing these entity words according to sentence: 1,25-dihydroxyvitamin D, VDR Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.

[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]

[ "compound", "protein" ]

1,25-dihydroxyvitamin D, VDR

DS.d1597_task2

Sentence: Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.

[ "Collectively", ",", "these", "studies", "identify", "a", "novel", "role", "for", "1,25-dihydroxyvitamin", "D", "(", "3", ")", "and", "the", "VDR", "in", "the", "control", "of", "adipocyte", "metabolism", "and", "lipid", "storage", "in", "vivo", "." ]

[ "compound", "protein" ]

Skin diseases is an umlsterm, patients is an umlsterm, evaluation is an umlsterm, medicine is an umlsterm, resource is an umlsterm, diagnosis is an umlsterm, guidelines is an umlsterm, evaluation is an umlsterm, role is an umlsterm, evaluation is an umlsterm, evaluation is an umlsterm, occupationally - related is an umlsterm, disorders is an umlsterm, multiple chemical sensitivity is an umlsterm

DerHautarzt.80490626.eng.abstr_task0

Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]

Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .

[ "Skin", "diseases", ",", "the", "psyche", "and", "psychological", "changes", "are", "often", "intertwined", ",", "especially", "in", "patients", "presenting", "for", "expert", "dermatologic", "opinion", ".", "In", "many", "cases", "an", "additional", "evaluation", "provided", "by", "psychotherapeutic", "medicine", "may", "be", "necessary", ".", "This", "resource", "may", "help", "with", "the", "diagnosis", ",", "explanation", "of", "the", "problem", "and", "estimation", "of", "the", "degree", "of", "disability", ".", "The", "different", "legal", "guidelines", "of", "the", "various", "evaluation", "boards", "must", "be", "considered", ".", "The", "role", "of", "psychotherapeutic", "evaluation", "is", "demonstrated", "through", "case", "examples", ".", "The", "evaluation", "of", "new", "possibly", "occupationally", "-", "related", "disorders", "such", "as", "multiple", "chemical", "sensitivity", "and", "mobbing", "is", "considered", "." ]

[ "umlsterm" ]

Skin diseases is an umlsterm, patients is an umlsterm, evaluation is an umlsterm, medicine is an umlsterm, resource is an umlsterm, diagnosis is an umlsterm, guidelines is an umlsterm, evaluation is an umlsterm, role is an umlsterm, evaluation is an umlsterm, evaluation is an umlsterm, occupationally - related is an umlsterm, disorders is an umlsterm, multiple chemical sensitivity is an umlsterm

DerHautarzt.80490626.eng.abstr_task1

Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please typing these entity words according to sentence: Skin diseases, patients, evaluation, medicine, resource, diagnosis, guidelines, evaluation, role, evaluation, evaluation, occupationally - related, disorders, multiple chemical sensitivity Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]

Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .

[ "Skin", "diseases", ",", "the", "psyche", "and", "psychological", "changes", "are", "often", "intertwined", ",", "especially", "in", "patients", "presenting", "for", "expert", "dermatologic", "opinion", ".", "In", "many", "cases", "an", "additional", "evaluation", "provided", "by", "psychotherapeutic", "medicine", "may", "be", "necessary", ".", "This", "resource", "may", "help", "with", "the", "diagnosis", ",", "explanation", "of", "the", "problem", "and", "estimation", "of", "the", "degree", "of", "disability", ".", "The", "different", "legal", "guidelines", "of", "the", "various", "evaluation", "boards", "must", "be", "considered", ".", "The", "role", "of", "psychotherapeutic", "evaluation", "is", "demonstrated", "through", "case", "examples", ".", "The", "evaluation", "of", "new", "possibly", "occupationally", "-", "related", "disorders", "such", "as", "multiple", "chemical", "sensitivity", "and", "mobbing", "is", "considered", "." ]

[ "umlsterm" ]

Skin diseases, patients, evaluation, medicine, resource, diagnosis, guidelines, evaluation, role, evaluation, evaluation, occupationally - related, disorders, multiple chemical sensitivity

DerHautarzt.80490626.eng.abstr_task2

Sentence: Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]

Skin diseases , the psyche and psychological changes are often intertwined , especially in patients presenting for expert dermatologic opinion . In many cases an additional evaluation provided by psychotherapeutic medicine may be necessary . This resource may help with the diagnosis , explanation of the problem and estimation of the degree of disability . The different legal guidelines of the various evaluation boards must be considered . The role of psychotherapeutic evaluation is demonstrated through case examples . The evaluation of new possibly occupationally-related disorders such as multiple chemical sensitivity and mobbing is considered .

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[ "umlsterm" ]

PMLRARalpha transgene is a DNA_domain_or_region, murine acute promyelocytic leukemia is an other_name

63364_task0

Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, other_name

[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.

[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]

[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]

PMLRARalpha transgene is a DNA_domain_or_region, murine acute promyelocytic leukemia is an other_name

63364_task1

Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please typing these entity words according to sentence: PMLRARalpha transgene, murine acute promyelocytic leukemia Options: DNA_domain_or_region, other_name

[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.

[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]

[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]

PMLRARalpha transgene, murine acute promyelocytic leukemia

63364_task2

Sentence: A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Instructions: please extract entity words from the input sentence

[ "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O" ]

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.

[ "A", "PMLRARalpha", "transgene", "initiates", "murine", "acute", "promyelocytic", "leukemia", "." ]

[ "other_name", "DNA_domain_or_region", "protein_molecule", "other_artificial_source", "DNA_molecule", "cell_type", "other_organic_compound", "multi_cell" ]

Short- and long - term effects is a Outcome_Physical, tactile massage is a Intervention_Physical, salivary cortisol concentrations is a Outcome_Physical, Parkinson ' s disease is a Participant_Condition, non - pharmacological therapies is a Intervention_Other, hypothalamic - pituitary - adrenal ( HPA ) axis . is a Outcome_Physical, basal diurnal and total secretion of salivary cortisol is a Outcome_Physical, tactile massage ( TM ) is a Intervention_Physical, Forty - five is a Participant_Sample-size, women and men is a Participant_Sex, aged 50 - 79 years is a Participant_Age, Twenty - nine is a Participant_Sample-size, 16 is a Participant_Sample-size, rest to music ( RTM ) is a Intervention_Control, Salivary cortisol is a Outcome_Physical, assess and compare cortisol concentrations is a Outcome_Physical, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration . is a Outcome_Physical, median cortisol concentrations is a Outcome_Physical, Cortisol concentrations is a Outcome_Physical, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . is a Outcome_Physical, Diurnal salivary cortisol rhythm is a Outcome_Physical, Salivary cortisol concentrations is a Outcome_Physical

62949_task0

Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Control, Intervention_Other, Outcome_Physical, Participant_Age, Participant_Sample-size

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Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .

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[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]

Short- and long - term effects is a Outcome_Physical, tactile massage is a Intervention_Physical, salivary cortisol concentrations is a Outcome_Physical, Parkinson ' s disease is a Participant_Condition, non - pharmacological therapies is a Intervention_Other, hypothalamic - pituitary - adrenal ( HPA ) axis . is a Outcome_Physical, basal diurnal and total secretion of salivary cortisol is a Outcome_Physical, tactile massage ( TM ) is a Intervention_Physical, Forty - five is a Participant_Sample-size, women and men is a Participant_Sex, aged 50 - 79 years is a Participant_Age, Twenty - nine is a Participant_Sample-size, 16 is a Participant_Sample-size, rest to music ( RTM ) is a Intervention_Control, Salivary cortisol is a Outcome_Physical, assess and compare cortisol concentrations is a Outcome_Physical, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration . is a Outcome_Physical, median cortisol concentrations is a Outcome_Physical, Cortisol concentrations is a Outcome_Physical, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . is a Outcome_Physical, Diurnal salivary cortisol rhythm is a Outcome_Physical, Salivary cortisol concentrations is a Outcome_Physical

62949_task1

Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . Instructions: please typing these entity words according to sentence: Short- and long - term effects, tactile massage, salivary cortisol concentrations, Parkinson ' s disease, non - pharmacological therapies, hypothalamic - pituitary - adrenal ( HPA ) axis ., basal diurnal and total secretion of salivary cortisol, tactile massage ( TM ), Forty - five, women and men, aged 50 - 79 years, Twenty - nine, 16, rest to music ( RTM ), Salivary cortisol, assess and compare cortisol concentrations, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration ., median cortisol concentrations, Cortisol concentrations, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD ., Diurnal salivary cortisol rhythm, Salivary cortisol concentrations Options: Intervention_Physical, Participant_Condition, Participant_Sex, Intervention_Control, Intervention_Other, Outcome_Physical, Participant_Age, Participant_Sample-size

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Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .

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[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]

Short- and long - term effects, tactile massage, salivary cortisol concentrations, Parkinson ' s disease, non - pharmacological therapies, hypothalamic - pituitary - adrenal ( HPA ) axis ., basal diurnal and total secretion of salivary cortisol, tactile massage ( TM ), Forty - five, women and men, aged 50 - 79 years, Twenty - nine, 16, rest to music ( RTM ), Salivary cortisol, assess and compare cortisol concentrations, impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time - point of the day , and levodopa doses on cortisol concentration ., median cortisol concentrations, Cortisol concentrations, age , gender , BMI , time - point for intervention , time interval between anti - parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD ., Diurnal salivary cortisol rhythm, Salivary cortisol concentrations

62949_task2

Sentence: Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 . Instructions: please extract entity words from the input sentence

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Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson 's disease : a randomised controlled pilot study . BACKGROUND Parkinson 's disease ( PD ) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal ( HPA ) axis . The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage ( TM ) . METHODS DESIGN Prospective , Controlled and Randomised Multicentre Trial . SETTING AND INTERVENTIONS Forty-five women and men , aged 50-79 years , were recruited . Twenty-nine of them were blindly randomised to tactile massage ( TM ) and 16 of them to the control group , rest to music ( RTM ) . Ten interventions were given during 8 weeks followed by a 26 weeks of follow up . Salivary cortisol was collected at 8 am , 1 pm , 8 pm , and 8 am the next day , on five occasions . With the first and eighth interventions , it was collected immediately before and after intervention . MAIN OUTCOME MEASURES The primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period . The secondary aim was to assess the impact of age , gender , body mass index ( BMI ) , duration and severity of PD , effects of interventional time-point of the day , and levodopa doses on cortisol concentration . RESULTS The median cortisol concentrations for all participants were 16.0 , 5.8 , 2.8 , and 14.0 nmol/L at baseline , later reproduced four times without significant differences . Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found . The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies . However , there was no significant difference between the TM and control groups . There were no significant correlations between cortisol concentrations and age , gender , BMI , time-point for intervention , time interval between anti-parkinson pharmacy intake and sampling , levodopa doses , duration , or severity of PD . CONCLUSIONS Diurnal salivary cortisol rhythm was normal . Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM , but there were no significant differences between the groups and no sustained long-term effect . No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics . TRIAL REGISTRATION ClinicalTrial.gov , NCT01734876 and FoU Sweden 108881 .

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[ "Outcome_Physical", "Intervention_Other", "Intervention_Physical", "Intervention_Control", "Participant_Condition", "Participant_Age", "Participant_Sex", "Participant_Sample-size" ]

Whipple operation is an umlsterm, standard is an umlsterm, operation is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, duodenopancreatectomy is an umlsterm, function is an umlsterm, Methods is an umlsterm, October is an umlsterm, quality of life is an umlsterm, operation is an umlsterm, time is an umlsterm, hospital is an umlsterm, morbidity is an umlsterm, Quality of life is an umlsterm, duodenopancreatectomy is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, age is an umlsterm, gender is an umlsterm, stage is an umlsterm, Operation is an umlsterm, time is an umlsterm, Morbidity is an umlsterm, quality of life is an umlsterm, quality of life is an umlsterm, appetite is an umlsterm, nausea is an umlsterm, diarrhea is an umlsterm, body weight is an umlsterm, postoperative is an umlsterm, quality of life is an umlsterm

DerChirurg.90701454.eng.abstr_task0

Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .

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[ "umlsterm" ]

Whipple operation is an umlsterm, standard is an umlsterm, operation is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, duodenopancreatectomy is an umlsterm, function is an umlsterm, Methods is an umlsterm, October is an umlsterm, quality of life is an umlsterm, operation is an umlsterm, time is an umlsterm, hospital is an umlsterm, morbidity is an umlsterm, Quality of life is an umlsterm, duodenopancreatectomy is an umlsterm, patients is an umlsterm, cancer is an umlsterm, head is an umlsterm, pancreas is an umlsterm, age is an umlsterm, gender is an umlsterm, stage is an umlsterm, Operation is an umlsterm, time is an umlsterm, Morbidity is an umlsterm, quality of life is an umlsterm, quality of life is an umlsterm, appetite is an umlsterm, nausea is an umlsterm, diarrhea is an umlsterm, body weight is an umlsterm, postoperative is an umlsterm, quality of life is an umlsterm

DerChirurg.90701454.eng.abstr_task1

Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . Instructions: please typing these entity words according to sentence: Whipple operation, standard, operation, patients, cancer, head, pancreas, duodenopancreatectomy, function, Methods, October, quality of life, operation, time, hospital, morbidity, Quality of life, duodenopancreatectomy, patients, cancer, head, pancreas, age, gender, stage, Operation, time, Morbidity, quality of life, quality of life, appetite, nausea, diarrhea, body weight, postoperative, quality of life Options: umlsterm

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Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .

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[ "umlsterm" ]

Whipple operation, standard, operation, patients, cancer, head, pancreas, duodenopancreatectomy, function, Methods, October, quality of life, operation, time, hospital, morbidity, Quality of life, duodenopancreatectomy, patients, cancer, head, pancreas, age, gender, stage, Operation, time, Morbidity, quality of life, quality of life, appetite, nausea, diarrhea, body weight, postoperative, quality of life

DerChirurg.90701454.eng.abstr_task2

Sentence: Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD . Instructions: please extract entity words from the input sentence

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Background : The Whipple operation ( PD ) is the standard operation in patients with cancer of the head of the pancreas and the periampullary region . However , the pylorus-preserving duodenopancreatectomy ( PPPD ) is supposed to be superior in gastrointestinal function . Methods : In a prospective randomized trial ( October 1994-October 1998 ) PD and PPPD were compared in terms of global and gastrointestinal quality of life , operation time , duration of hospital stay , transfusions and perioperative morbidity . Quality of life was analyzed under standardized conditions ( EORTC-QLQ-30) pre- and postoperatively ( weeks 2 , 6 , 12 , 24 , 36 , 48 , and 60 ) . Results : A duodenopancreatectomy was performed in 48 patients because of cancer of the head of the pancreas ( n = 38 ) and the periampullary region ( n = 10 ) ( PD , n = 24 ; PPPD , n = 24 ) . The PD and PPPD groups did not differ according to age , gender or UICC stage . Operation time was shorter in the PPPD group ( 206 +/- 48 vs 306 +/- 54 min ) ( P 0.05 ) . Morbidity did not differ between the two groups ( PPPD 20 % vs PD 30 % , P > 0.05 ) . While there was no difference in global quality of life , gastrointestinal quality of life was postoperatively increased in the PPPD group regarding appetite , nausea and diarrhea ( P 0.05 ) . While the preoperative body weight was reached after 6 months in 85 % of the PPPD group ( n = 20 ) , this was true in only 60 % of the PD-group ( n = 14 ) ( P 0.05 ) . Conclusion : PPPD seems to be associated with a better postoperative gastrointestinal quality of life than PD .

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[ "umlsterm" ]

dream is an umlsterm, hospital is an umlsterm, computer is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, discharge is an umlsterm, patients is an umlsterm, hospital information systems is an umlsterm, information systems is an umlsterm, environment is an umlsterm, discharge is an umlsterm, administration is an umlsterm, universal is an umlsterm, solution is an umlsterm, communication is an umlsterm, information systems is an umlsterm

DerGynaekologe.00330194.eng.abstr_task0

Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .

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[ "umlsterm" ]

dream is an umlsterm, hospital is an umlsterm, computer is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, discharge is an umlsterm, patients is an umlsterm, hospital information systems is an umlsterm, information systems is an umlsterm, environment is an umlsterm, discharge is an umlsterm, administration is an umlsterm, universal is an umlsterm, solution is an umlsterm, communication is an umlsterm, information systems is an umlsterm

DerGynaekologe.00330194.eng.abstr_task1

Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please typing these entity words according to sentence: dream, hospital, computer, diagnosis, treatment, discharge, patients, hospital information systems, information systems, environment, discharge, administration, universal, solution, communication, information systems Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .

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[ "umlsterm" ]

dream, hospital, computer, diagnosis, treatment, discharge, patients, hospital information systems, information systems, environment, discharge, administration, universal, solution, communication, information systems

DerGynaekologe.00330194.eng.abstr_task2

Sentence: The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems . Instructions: please extract entity words from the input sentence

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The dream of every hospital computer scientist is a completely computerized flow of information in his/her facility : admission , diagnosis , treatment , transfer , and discharge of patients . However , in developing such general hospital information systems , one runs into the following problems : ( 1 ) medical and administrative information systems form a very heterogeneous environment ; ( 2 ) the structure of medical information is extremely complex , except for certain limited administrative data ( admission , transfer , and discharge , for example ) needed by the clinic administration . As a result it is nearly impossible to transfer medical information from one system to another without a loss of data . One cannot expect a universal solution to this problem within the next few years . Therefore we present a concept which , based on existing tools , allows communication between medical information systems .

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[ "umlsterm" ]

paraquat is a CHEMICAL

23261591_task0

Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.

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[ "CHEMICAL", "GENE-Y" ]

paraquat is a CHEMICAL

23261591_task1

Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please typing these entity words according to sentence: paraquat Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.

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[ "CHEMICAL", "GENE-Y" ]

paraquat

23261591_task2

Sentence: Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model.

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[ "CHEMICAL", "GENE-Y" ]

efficacy is a Outcome_Other, atorvastatin is a Intervention_Pharmacological, simvastatin is a Intervention_Pharmacological, pravastatin is a Intervention_Pharmacological, lovastatin is a Intervention_Pharmacological, fluvastatin is a Intervention_Pharmacological, patients with hypercholesterolemia is a Participant_Condition, multicenter is a Participant_Condition, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg is a Intervention_Pharmacological, simvastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, pravastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, lovastatin 20 , 40 , and 80 mg is a Intervention_Pharmacological, fluvastatin 20 and 40 mg . is a Intervention_Pharmacological, 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ) is a Participant_Sample-size, plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations is a Outcome_Physical, Atorvastatin is a Intervention_Pharmacological, tolerability is a Outcome_Mental, serum transaminases or myositis . is a Outcome_Adverse-effects

91483_task0

Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .

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[ "Participant_Sample-size", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Mental", "Outcome_Other" ]

efficacy is a Outcome_Other, atorvastatin is a Intervention_Pharmacological, simvastatin is a Intervention_Pharmacological, pravastatin is a Intervention_Pharmacological, lovastatin is a Intervention_Pharmacological, fluvastatin is a Intervention_Pharmacological, patients with hypercholesterolemia is a Participant_Condition, multicenter is a Participant_Condition, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg is a Intervention_Pharmacological, simvastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, pravastatin 10 , 20 , and 40 mg is a Intervention_Pharmacological, lovastatin 20 , 40 , and 80 mg is a Intervention_Pharmacological, fluvastatin 20 and 40 mg . is a Intervention_Pharmacological, 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ) is a Participant_Sample-size, plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations is a Outcome_Physical, Atorvastatin is a Intervention_Pharmacological, tolerability is a Outcome_Mental, serum transaminases or myositis . is a Outcome_Adverse-effects

91483_task1

Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please typing these entity words according to sentence: efficacy, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, patients with hypercholesterolemia, multicenter, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg, simvastatin 10 , 20 , and 40 mg, pravastatin 10 , 20 , and 40 mg, lovastatin 20 , 40 , and 80 mg, fluvastatin 20 and 40 mg ., 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ), plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations, Atorvastatin, tolerability, serum transaminases or myositis . Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .

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[ "Participant_Sample-size", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Mental", "Outcome_Other" ]

efficacy, atorvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, patients with hypercholesterolemia, multicenter, 3-hydroxy-3-methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg, simvastatin 10 , 20 , and 40 mg, pravastatin 10 , 20 , and 40 mg, lovastatin 20 , 40 , and 80 mg, fluvastatin 20 and 40 mg ., 534 hypercholesterolemic patients ( low - density lipoprotein [ LDL ] cholesterol > or = 160 mg / dl [ 4.2 mmol / L ] and triglycerides < or = 400 mg / dl [ 4.5 mmol / L ] ), plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high - density lipoprotein cholesterol concentrations, Atorvastatin, tolerability, serum transaminases or myositis .

91483_task2

Sentence: Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis . Instructions: please extract entity words from the input sentence

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Comparative dose efficacy study of atorvastatin versus simvastatin , pravastatin , lovastatin , and fluvastatin in patients with hypercholesterolemia ( the CURVES study ) The objective of this multicenter , randomized , open-label , parallel-group , 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin 10 , 20 , 40 , and 80 mg compared with simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 , 40 , and 80 mg , and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients ( low-density lipoprotein [ LDL ] cholesterol > or = 160 mg/dl [ 4.2 mmol/L ] and triglycerides < or = 400 mg/dl [ 4.5 mmol/L ] ) . The efficacy end points were mean percent change in plasma LDL cholesterol ( primary ) , total cholesterol , triglycerides , and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment ( week 8 ) . Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in LDL cholesterol , -38 % , -46 % , and -51 % , respectively , than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than ( p < or = 0.02 ) simvastatin 10 , 20 , and 40 mg , pravastatin 10 , 20 , and 40 mg , lovastatin 20 and 40 mg , and fluvastatin 20 and 40 mg. Atorvastatin 10 , 20 , and 40 mg produced greater ( p < or = 0.01 ) reductions in total cholesterol than the milligram equivalent doses of simvastatin , pravastatin , lovastatin , and fluvastatin . All reductase inhibitors studied had similar tolerability . There were no incidences of persistent elevations in serum transaminases or myositis .

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[ "Participant_Sample-size", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Outcome_Adverse-effects", "Outcome_Mental", "Outcome_Other" ]

Risiko is an umlsterm, Rolle is an umlsterm, Ultraschalltechniken is an umlsterm, Parathormon is an umlsterm, Dehnbarkeit is an umlsterm, Arterien is an umlsterm, niereninsuffizienten is an umlsterm, Patienten is an umlsterm, Parathormonkonzentrationen is an umlsterm, Parathormons is an umlsterm, Uraemie is an umlsterm, Endothel is an umlsterm, erkanntes is an umlsterm, Parathormons is an umlsterm, Patienten is an umlsterm, Hyperparathyreoidismus is an umlsterm, Parathyreoidektomie is an umlsterm, blutdrucksteigernden is an umlsterm, Parathormons is an umlsterm, Arbeit is an umlsterm, Parathormons is an umlsterm, Arterien is an umlsterm, Endothelfunktion is an umlsterm

MedizinischeKlinik.00950267.ger.abstr_task0

Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .

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[ "umlsterm" ]

Risiko is an umlsterm, Rolle is an umlsterm, Ultraschalltechniken is an umlsterm, Parathormon is an umlsterm, Dehnbarkeit is an umlsterm, Arterien is an umlsterm, niereninsuffizienten is an umlsterm, Patienten is an umlsterm, Parathormonkonzentrationen is an umlsterm, Parathormons is an umlsterm, Uraemie is an umlsterm, Endothel is an umlsterm, erkanntes is an umlsterm, Parathormons is an umlsterm, Patienten is an umlsterm, Hyperparathyreoidismus is an umlsterm, Parathyreoidektomie is an umlsterm, blutdrucksteigernden is an umlsterm, Parathormons is an umlsterm, Arbeit is an umlsterm, Parathormons is an umlsterm, Arterien is an umlsterm, Endothelfunktion is an umlsterm

MedizinischeKlinik.00950267.ger.abstr_task1

Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please typing these entity words according to sentence: Risiko, Rolle, Ultraschalltechniken, Parathormon, Dehnbarkeit, Arterien, niereninsuffizienten, Patienten, Parathormonkonzentrationen, Parathormons, Uraemie, Endothel, erkanntes, Parathormons, Patienten, Hyperparathyreoidismus, Parathyreoidektomie, blutdrucksteigernden, Parathormons, Arbeit, Parathormons, Arterien, Endothelfunktion Options: umlsterm

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Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .

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[ "umlsterm" ]

Risiko, Rolle, Ultraschalltechniken, Parathormon, Dehnbarkeit, Arterien, niereninsuffizienten, Patienten, Parathormonkonzentrationen, Parathormons, Uraemie, Endothel, erkanntes, Parathormons, Patienten, Hyperparathyreoidismus, Parathyreoidektomie, blutdrucksteigernden, Parathormons, Arbeit, Parathormons, Arterien, Endothelfunktion

MedizinischeKlinik.00950267.ger.abstr_task2

Sentence: Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein . Instructions: please extract entity words from the input sentence

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Funktionelle Veraenderungen der arteriellen Gefaesswand spielen fuer das kardiovaskulaere Risiko eine wichtige Rolle und lassen sich mittels moderner Ultraschalltechniken nichtinvasiv messen . Neuere Studien zeigen , dass Parathormon eine Reihe komplexer Effekte auf das kardiovaskulaere System hat und neben Strukturveraenderungen der Gefaesswand insbesondere den Tonus und die Dehnbarkeit grosser Arterien beeinflusst . So konnte gezeigt werden , dass bei niereninsuffizienten Patienten erhoehte Parathormonkonzentrationen mit einer Verminderung der arteriellen Distensibilitaet und einer Zunahme der Intima-Media-Dicke einhergehen . Ein permissiver Effekt des Parathormons fuer die Gefaesswandveraenderungen bei Uraemie wird diskutiert . Das Endothel ist ein neu erkanntes Zielorgan des Parathormons . Bei Patienten mit primaeren Hyperparathyreoidismus wurde eine endotheliale Dysfunktion nachgewiesen , die nach Parathyreoidektomie reversibel ist . Moeglicherweise tragen die Effekte auf die funktionellen Gefaesswandeigenschaften zur blutdrucksteigernden Wirkung des Parathormons bei . Die vorliegende Arbeit gibt einen Ueberblick ueml , ber die kardiovaskulaeren Effekte des Parathormons und geht insbesondere auf Veraenderungen der Struktur , des Tonus , der Distensibilitaet grosser Arterien und der Endothelfunktion ein .

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[ "umlsterm" ]

Methylenetetrahydrofolate dehydrogenase is a protein, methenyltetrahydrofolate cyclohydrolase is a protein, formyltetrahydrofolate synthetase is a protein, MTHFD1 is a protein

DS.d1010_task0

Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein

[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.

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[ "protein", "compound" ]

Methylenetetrahydrofolate dehydrogenase is a protein, methenyltetrahydrofolate cyclohydrolase is a protein, formyltetrahydrofolate synthetase is a protein, MTHFD1 is a protein

DS.d1010_task1

Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please typing these entity words according to sentence: Methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, MTHFD1 Options: protein

[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.

[ "Methylenetetrahydrofolate", "dehydrogenase", ")", "methenyltetrahydrofolate", "cyclohydrolase", ")", "formyltetrahydrofolate", "synthetase", "(", "MTHFD1", ")", "is", "a", "trifunctional", "enzyme", "that", "interconverts", "tetrahydrofolate", "(", "THF", ")", "derivatives", "for", "nucleotide", "synthesis", "." ]

[ "protein", "compound" ]

Methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, MTHFD1

DS.d1010_task2

Sentence: Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. Instructions: please extract entity words from the input sentence

[ "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "I-protein", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.

[ "Methylenetetrahydrofolate", "dehydrogenase", ")", "methenyltetrahydrofolate", "cyclohydrolase", ")", "formyltetrahydrofolate", "synthetase", "(", "MTHFD1", ")", "is", "a", "trifunctional", "enzyme", "that", "interconverts", "tetrahydrofolate", "(", "THF", ")", "derivatives", "for", "nucleotide", "synthesis", "." ]

[ "protein", "compound" ]

implantations is an umlsterm, silastic is an umlsterm, Complications is an umlsterm, surgery is an umlsterm, amputation is an umlsterm, pain is an umlsterm, single - stem is an umlsterm, double - stem is an umlsterm, time is an umlsterm, operation is an umlsterm, pain is an umlsterm, rheumatoid arthritis is an umlsterm, arthrosis is an umlsterm, disease is an umlsterm, patients is an umlsterm, pain is an umlsterm, arthrosis is an umlsterm

DerOrthopaede.60250332.eng.abstr_task0

Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .

[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]

[ "umlsterm" ]

implantations is an umlsterm, silastic is an umlsterm, Complications is an umlsterm, surgery is an umlsterm, amputation is an umlsterm, pain is an umlsterm, single - stem is an umlsterm, double - stem is an umlsterm, time is an umlsterm, operation is an umlsterm, pain is an umlsterm, rheumatoid arthritis is an umlsterm, arthrosis is an umlsterm, disease is an umlsterm, patients is an umlsterm, pain is an umlsterm, arthrosis is an umlsterm

DerOrthopaede.60250332.eng.abstr_task1

Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please typing these entity words according to sentence: implantations, silastic, Complications, surgery, amputation, pain, single - stem, double - stem, time, operation, pain, rheumatoid arthritis, arthrosis, disease, patients, pain, arthrosis Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .

[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]

[ "umlsterm" ]

implantations, silastic, Complications, surgery, amputation, pain, single - stem, double - stem, time, operation, pain, rheumatoid arthritis, arthrosis, disease, patients, pain, arthrosis

DerOrthopaede.60250332.eng.abstr_task2

Sentence: This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

This report is based upon experience with 592 implantations of Swanson silastic spacer between 1978 and 1992. The results of 430 cases were followed up in 1995. Complications were observed in 31 cases and required further surgery . In 18 cases , the spacer was resected ; in 2 cases a distal amputation was necessary . Due to pain , the spacer was changed in 11 cases , in 5 cases from a single-stem to a double-stem version . Radiological reactions increase over time following the operation without correlation to pain . The results in cases of rheumatoid arthritis and arthrosis disease are compared . Approximately 80 % of the patients are free of pain and more than 90 % are satisfied with the functional results . The results of the arthrosis group are slightly better .

[ "This", "report", "is", "based", "upon", "experience", "with", "592", "implantations", "of", "Swanson", "silastic", "spacer", "between", "1978", "and", "1992", ".", "The", "results", "of", "430", "cases", "were", "followed", "up", "in", "1995", ".", "Complications", "were", "observed", "in", "31", "cases", "and", "required", "further", "surgery", ".", "In", "18", "cases", ",", "the", "spacer", "was", "resected", ";", "in", "2", "cases", "a", "distal", "amputation", "was", "necessary", ".", "Due", "to", "pain", ",", "the", "spacer", "was", "changed", "in", "11", "cases", ",", "in", "5", "cases", "from", "a", "single", "-", "stem", "to", "a", "double", "-", "stem", "version", ".", "Radiological", "reactions", "increase", "over", "time", "following", "the", "operation", "without", "correlation", "to", "pain", ".", "The", "results", "in", "cases", "of", "rheumatoid", "arthritis", "and", "arthrosis", "disease", "are", "compared", ".", "Approximately", "80", "%", "of", "the", "patients", "are", "free", "of", "pain", "and", "more", "than", "90", "%", "are", "satisfied", "with", "the", "functional", "results", ".", "The", "results", "of", "the", "arthrosis", "group", "are", "slightly", "better", "." ]

[ "umlsterm" ]

Arbeit is an umlsterm, Karzinomen is an umlsterm, weiblichen is an umlsterm, Brust is an umlsterm

DerPathologe.70180045.ger.abstr_task0

Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .

[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]

[ "umlsterm" ]

Arbeit is an umlsterm, Karzinomen is an umlsterm, weiblichen is an umlsterm, Brust is an umlsterm

DerPathologe.70180045.ger.abstr_task1

Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please typing these entity words according to sentence: Arbeit, Karzinomen, weiblichen, Brust Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .

[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]

[ "umlsterm" ]

Arbeit, Karzinomen, weiblichen, Brust

DerPathologe.70180045.ger.abstr_task2

Sentence: In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In der vorliegenden Arbeit werden klinische und morphologische Befunde bei 54 Neuerkrankungen in den Jahren von 1978-1996 ausgewertet und in der Diskussion mit 528 Karzinomen der weiblichen Brust aus dem gleichen Einzugsgebiet verglichen .

[ "In", "der", "vorliegenden", "Arbeit", "werden", "klinische", "und", "morphologische", "Befunde", "bei", "54", "Neuerkrankungen", "in", "den", "Jahren", "von", "1978", "-", "1996", "ausgewertet", "und", "in", "der", "Diskussion", "mit", "528", "Karzinomen", "der", "weiblichen", "Brust", "aus", "dem", "gleichen", "Einzugsgebiet", "verglichen", "." ]

[ "umlsterm" ]

Streptokinase is a GENE-N, protease - activated receptor-1 is a GENE-Y

10666203_task0

Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.

[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Streptokinase is a GENE-N, protease - activated receptor-1 is a GENE-Y

10666203_task1

Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please typing these entity words according to sentence: Streptokinase, protease - activated receptor-1 Options: GENE-Y, GENE-N

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.

[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Streptokinase, protease - activated receptor-1

10666203_task2

Sentence: Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1.

[ "Streptokinase", "-", "induced", "platelet", "activation", "involves", "antistreptokinase", "antibodies", "and", "cleavage", "of", "protease", "-", "activated", "receptor-1", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

cytochrome c is a protein, Ca(2 is a compound

DS.d427_task0

Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.

[ "Here", ",", "we", "assessed", "the", "regulation", "of", "pancreatic", "cytochrome", "c", "release", "by", "Ca(2", "+", ")", ",", "mitochondrial", "membrane", "potential", "(", "Delta", "Psi", "m", ")", ",", "and", "reactive", "oxygen", "species", "(", "ROS", ")", ",", "the", "signals", "involved", "in", "acute", "pancreatitis", "." ]

[ "protein", "compound" ]

cytochrome c is a protein, Ca(2 is a compound

DS.d427_task1

Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please typing these entity words according to sentence: cytochrome c, Ca(2 Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.

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cytochrome c, Ca(2

DS.d427_task2

Sentence: Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis. Instructions: please extract entity words from the input sentence

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Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.

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IL-12 is a Entity, IFN regulating factor-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, CD4 is a Protein, IL-12 is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, genes is a Entity, IL-12 is a Entity, MIP-1alpha is a Protein, MIP-1beta is a Protein, IL-1RA is a Protein, IFN regulatory factor-1 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, IRF-1 is a Protein, IFN - gamma is a Protein, IL-2 is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-12 is a Entity, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, STAT4 is a Protein, IRF-1 is a Protein, promoter is a Entity, IL-12 is a Entity, IRF-1 is a Protein, IL-4 is a Protein, IRF-1 is a Protein, IRF-1 is a Protein, IL-12 is a Entity, IL-12 is a Entity

218_task0

Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.

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[ "Protein", "Entity" ]

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218_task1

Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please typing these entity words according to sentence: IL-12, IFN regulating factor-1, IRF-1, IL-12, CD4, IL-12, IL-12, genes, IL-12, genes, IL-12, MIP-1alpha, MIP-1beta, IL-1RA, IFN regulatory factor-1, IRF-1, IRF-1, IL-12, IRF-1, IL-12, IRF-1, IFN - gamma, IL-2, IL-12, IRF-1, IL-12, STAT4, IRF-1, STAT4, IRF-1, STAT4, IRF-1, promoter, IL-12, IRF-1, IL-4, IRF-1, IRF-1, IL-12, IL-12 Options: Entity, Protein

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IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.

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[ "Protein", "Entity" ]

IL-12, IFN regulating factor-1, IRF-1, IL-12, CD4, IL-12, IL-12, genes, IL-12, genes, IL-12, MIP-1alpha, MIP-1beta, IL-1RA, IFN regulatory factor-1, IRF-1, IRF-1, IL-12, IRF-1, IL-12, IRF-1, IFN - gamma, IL-2, IL-12, IRF-1, IL-12, STAT4, IRF-1, STAT4, IRF-1, STAT4, IRF-1, promoter, IL-12, IRF-1, IL-4, IRF-1, IRF-1, IL-12, IL-12

218_task2

Sentence: IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor. Instructions: please extract entity words from the input sentence

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IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified. To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes. We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1). IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses. We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells. We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production. Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not. The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways. First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA. In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1. Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.

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[ "Protein", "Entity" ]

Patienten is an umlsterm, Fistel is an umlsterm, Duodenum is an umlsterm, Diagnose is an umlsterm, Endoskopie is an umlsterm, Computertomographie is an umlsterm, Fistelsanierung is an umlsterm, Prothesenmaterials is an umlsterm, Duodenalverschluss is an umlsterm, Diagnostik is an umlsterm, Therapieverfahren is an umlsterm

Gefaesschirurgie.70020126.ger.abstr_task0

Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .

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[ "umlsterm" ]

Patienten is an umlsterm, Fistel is an umlsterm, Duodenum is an umlsterm, Diagnose is an umlsterm, Endoskopie is an umlsterm, Computertomographie is an umlsterm, Fistelsanierung is an umlsterm, Prothesenmaterials is an umlsterm, Duodenalverschluss is an umlsterm, Diagnostik is an umlsterm, Therapieverfahren is an umlsterm

Gefaesschirurgie.70020126.ger.abstr_task1

Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please typing these entity words according to sentence: Patienten, Fistel, Duodenum, Diagnose, Endoskopie, Computertomographie, Fistelsanierung, Prothesenmaterials, Duodenalverschluss, Diagnostik, Therapieverfahren Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .

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[ "umlsterm" ]

Patienten, Fistel, Duodenum, Diagnose, Endoskopie, Computertomographie, Fistelsanierung, Prothesenmaterials, Duodenalverschluss, Diagnostik, Therapieverfahren

Gefaesschirurgie.70020126.ger.abstr_task2

Sentence: Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die vorliegende Kasuistik schildert den Fall eines 52jaehrigen Patienten , der 33 Monate nach Implantation einer Aortenrohrprothese eine sekundaere aortoenterale Fistel Typ 2 zum Duodenum entwickelte . Die praeoperative Diagnose wurde durch eine obere Endoskopie und eine abdominelle Computertomographie gestellt . Die Fistelsanierung erfolgte durch eine In-situ-Rekonstruktion mit Omentumplastik nach Entfernung des alten Prothesenmaterials und Duodenalverschluss . Es werden die Wertigkeit der praeoperativen Diagnostik und die 2 alternativen operativen Therapieverfahren , die In-situ-Rekonstruktion und die extra-anatomische Revaskularisation diskutiert .

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[ "umlsterm" ]

tumor necrosis factor alpha is a Protein, TNF- alpha is a Protein, TNF - alpha is a Protein

733_task0

Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.

[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]

[ "Protein" ]

tumor necrosis factor alpha is a Protein, TNF- alpha is a Protein, TNF - alpha is a Protein

733_task1

Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please typing these entity words according to sentence: tumor necrosis factor alpha, TNF- alpha, TNF - alpha Options: Protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.

[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]

[ "Protein" ]

tumor necrosis factor alpha, TNF- alpha, TNF - alpha

733_task2

Sentence: S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription. We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2). In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2. Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe. SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2. Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein. Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.

[ "S", "-", "allyl", "cysteine", "inhibits", "activation", "of", "nuclear", "factor", "kappa", "B", "in", "human", "T", "cells", ".", "\n", "Reactive", "oxygen", "species", "are", "involved", "in", "signal", "transduction", "pathways", "leading", "to", "nuclear", "factor", "kappa", "B", "(", "NF", "-", "kappa", "B", ")", "activation", "which", "has", "been", "implicated", "in", "the", "regulation", "of", "gene", "transcription", ".", "We", "recently", "reported", "that", "a", "garlic", "compound", ",", "S", "-", "allyl", "cysteine", "(", "SAC", ")", ",", "protects", "bovine", "pulmonary", "artery", "endothelial", "cells", "from", "oxidant", "injury", "induced", "by", "hydrogen", "peroxide", "(", "H2O2", ")", ".", "In", "this", "study", "we", "determined", "the", "effects", "of", "SAC", "on", "NF", "-", "kappa", "B", "activation", "in", "human", "T", "lymphocytes", "(", "Jurkat", "cells", ")", "induced", "by", "tumor", "necrosis", "factor", "alpha", "(", "TNF-", "alpha", ")", "and", "H2O2", ".", "Activated", "NF", "-", "kappa", "B", "in", "nuclear", "extracts", "was", "measured", "by", "an", "electrophoretic", "mobility", "shift", "assay", "using", "32P", "-", "labeled", "probe", ".", "SAC", "consistently", "exhibited", "a", "dose", "-", "dependent", "inhibition", "of", "NF", "-", "kappa", "B", "activation", "induced", "by", "both", "TNF", "-", "alpha", "and", "H2O2", ".", "Supershift", "with", "specific", "antibodies", "to", "NF", "-", "kappa", "B", "subunits", "confirmed", "that", "the", "inducible", "retarded", "bands", "observed", "in", "the", "EMSA", "and", "p65-p50", "heterodimer", "of", "the", "NF", "-", "kappa", "B", "/", "Rel", "protein", ".", "Our", "data", "suggest", "that", "SAC", "may", "act", "via", "antioxidant", "mechanisms", "to", "block", "NF", "-", "kappa", "B", "activation", "in", "Jurkat", "cells", "." ]

[ "Protein" ]

Langzeiteffekt is an umlsterm, DNase is an umlsterm, Patienten is an umlsterm, Mukoviszidose is an umlsterm

MonatsschriftKinderheilkunde.91470573.ger.abstr_task0

Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .

[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]

[ "umlsterm" ]

Langzeiteffekt is an umlsterm, DNase is an umlsterm, Patienten is an umlsterm, Mukoviszidose is an umlsterm

MonatsschriftKinderheilkunde.91470573.ger.abstr_task1

Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please typing these entity words according to sentence: Langzeiteffekt, DNase, Patienten, Mukoviszidose Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .

[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]

[ "umlsterm" ]

Langzeiteffekt, DNase, Patienten, Mukoviszidose

MonatsschriftKinderheilkunde.91470573.ger.abstr_task2

Sentence: Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]

Fragestellung : Wir untersuchten den Langzeiteffekt von DNase bei Patienten mit Mukoviszidose .

[ "Fragestellung", ":", "Wir", "untersuchten", "den", "Langzeiteffekt", "von", "DNase", "bei", "Patienten", "mit", "Mukoviszidose", "." ]

[ "umlsterm" ]

Imidazo- and 2-Methylimidazo[2,1-b]thiazole is a CHEMICAL, Ghrelin Receptor is a GENE-Y

23610086_task0

Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]

Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.

[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]

[ "CHEMICAL", "GENE-Y" ]

Imidazo- and 2-Methylimidazo[2,1-b]thiazole is a CHEMICAL, Ghrelin Receptor is a GENE-Y

23610086_task1

Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please typing these entity words according to sentence: Imidazo- and 2-Methylimidazo[2,1-b]thiazole, Ghrelin Receptor Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]

Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.

[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]

[ "CHEMICAL", "GENE-Y" ]

Imidazo- and 2-Methylimidazo[2,1-b]thiazole, Ghrelin Receptor

23610086_task2

Sentence: Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O" ]

Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-based Inverse Agonists of the Ghrelin Receptor.

[ "Reactive", "Metabolite", "Trapping", "Studies", "on", "Imidazo-", "and", "2-Methylimidazo[2,1-b]thiazole", "-", "based", "Inverse", "Agonists", "of", "the", "Ghrelin", "Receptor", "." ]

[ "CHEMICAL", "GENE-Y" ]

IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, NF - kappa B - like sequence is a Entity, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-8 is a Protein, IL-8 is a Protein

494_task0

Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.

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[ "Entity", "Protein" ]

IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, NF - kappa B - like sequence is a Entity, IL-8 is a Protein, CD28 is a Protein, IL-8 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-8 is a Protein, IL-8 is a Protein

494_task1

Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please typing these entity words according to sentence: IL-8, CD28, IL-8, CD28, IL-8, CD28, IL-8, CD28, NF - kappa B - like sequence, IL-8, CD28, IL-8, CD28, CD28, IL-8, IL-8 Options: Entity, Protein

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Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.

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[ "Entity", "Protein" ]

IL-8, CD28, IL-8, CD28, IL-8, CD28, IL-8, CD28, NF - kappa B - like sequence, IL-8, CD28, IL-8, CD28, CD28, IL-8, IL-8

494_task2

Sentence: Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway. IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells. Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes. Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion. Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element. Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.

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[ "Entity", "Protein" ]

N - acetylcysteine inhibition is an other_name, cytokine - induced E - selectin is a protein_molecule, VCAM-1 expression is an other_name

59018_task0

Sentence: Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_molecule, other_name

[ "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-other_name", "I-other_name", "O" ]

Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.

[ "Distinct", "mechanisms", "for", "N", "-", "acetylcysteine", "inhibition", "of", "cytokine", "-", "induced", "E", "-", "selectin", "and", "VCAM-1", "expression", "." ]

[ "other_name", "protein_molecule", "DNA_domain_or_region", "other_organic_compound", "DNA_molecule", "(OR RNA_molecule RNA_molecule)", "RNA_family_or_group", "protein_complex", "DNA_family_or_group", "amino_acid_monomer", "peptide", "lipid", "cell_type", "" ]

N - acetylcysteine inhibition is an other_name, cytokine - induced E - selectin is a protein_molecule, VCAM-1 expression is an other_name

59018_task1

Sentence: Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Instructions: please typing these entity words according to sentence: N - acetylcysteine inhibition, cytokine - induced E - selectin, VCAM-1 expression Options: protein_molecule, other_name

[ "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-other_name", "I-other_name", "O" ]

Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.

[ "Distinct", "mechanisms", "for", "N", "-", "acetylcysteine", "inhibition", "of", "cytokine", "-", "induced", "E", "-", "selectin", "and", "VCAM-1", "expression", "." ]

[ "other_name", "protein_molecule", "DNA_domain_or_region", "other_organic_compound", "DNA_molecule", "(OR RNA_molecule RNA_molecule)", "RNA_family_or_group", "protein_complex", "DNA_family_or_group", "amino_acid_monomer", "peptide", "lipid", "cell_type", "" ]