bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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noninvasive haemoglobin measurement, pulse oximetry, oximetry haemoglobin, infusion experiments	57863_task2	Sentence: Accuracy of noninvasive haemoglobin measurement by pulse oximetry depends on the type of infusion fluid . CONTEXT Measurement of blood haemoglobin concentration by pulse oximetry could be of value in determining when erythrocytes should be transfused during surgery , but the effect of infusion fluids on the results is unclear . OBJECTIVE To study the effect of crystalloid and colloid fluid on the accuracy ( bias ) and precision of pulse oximetry haemoglobin estimation to indicate the venous haemoglobin concentration in volunteers . DESIGN Open interventional crossover study . SETTING Single university hospital . PARTICIPANTS Ten male volunteers aged 18-28 ( mean 22 ) years . INTERVENTIONS Each volunteer underwent three infusion experiments on separate days and in random order . The infusions were Ringer 's acetate ( 20 ml kg ) , hydroxyethyl starch 130/0.4 ( 10 ml kg ) and a combination of both . RESULTS At the end of the infusions of Ringer 's acetate , pulse oximetry haemoglobin concentration had decreased more than the true haemoglobin concentration ( 15 vs. 8 % ; P < 0.005 ; n = 10 ) whereas starch solution decreased pulse oximetry haemoglobin concentration less than true haemoglobin concentration ( 7 vs. 11 % ; P < 0.02 ; n = 20 ) . The same differences were seen when the fluids were infused separately and when they were combined . The overall difference between all 956 pairs of pulse oximetry haemoglobin concentration and true haemoglobin concentrations ( the bias ) averaged only -0.7 g l whereas the 95 % prediction interval was wide , ranging from -24.9 to 23.7 g l. In addition to the choice of infusion fluid , the bias was strongly dependent on the volunteer ( each factor , P < 0.001 ) . CONCLUSION The bias of measuring haemoglobin concentration by pulse oximetry is dependent on whether a crystalloid or a colloid fluid is infused . TRIAL REGISTRATION ClinicalTrials identifier : NCT01195025 . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Accuracy of noninvasive haemoglobin measurement by pulse oximetry depends on the type of infusion fluid . CONTEXT Measurement of blood haemoglobin concentration by pulse oximetry could be of value in determining when erythrocytes should be transfused during surgery , but the effect of infusion fluids on the results is unclear . OBJECTIVE To study the effect of crystalloid and colloid fluid on the accuracy ( bias ) and precision of pulse oximetry haemoglobin estimation to indicate the venous haemoglobin concentration in volunteers . DESIGN Open interventional crossover study . SETTING Single university hospital . PARTICIPANTS Ten male volunteers aged 18-28 ( mean 22 ) years . INTERVENTIONS Each volunteer underwent three infusion experiments on separate days and in random order . The infusions were Ringer 's acetate ( 20 ml kg ) , hydroxyethyl starch 130/0.4 ( 10 ml kg ) and a combination of both . RESULTS At the end of the infusions of Ringer 's acetate , pulse oximetry haemoglobin concentration had decreased more than the true haemoglobin concentration ( 15 vs. 8 % ; P < 0.005 ; n = 10 ) whereas starch solution decreased pulse oximetry haemoglobin concentration less than true haemoglobin concentration ( 7 vs. 11 % ; P < 0.02 ; n = 20 ) . The same differences were seen when the fluids were infused separately and when they were combined . The overall difference between all 956 pairs of pulse oximetry haemoglobin concentration and true haemoglobin concentrations ( the bias ) averaged only -0.7 g l whereas the 95 % prediction interval was wide , ranging from -24.9 to 23.7 g l. In addition to the choice of infusion fluid , the bias was strongly dependent on the volunteer ( each factor , P < 0.001 ) . CONCLUSION The bias of measuring haemoglobin concentration by pulse oximetry is dependent on whether a crystalloid or a colloid fluid is infused . TRIAL REGISTRATION ClinicalTrials identifier : NCT01195025 .	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verprolin is a Gene/protein/RNA, cofilin is a Gene/protein/RNA, actin is a Gene/protein/RNA	280_task0	Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]	First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.	[ "First", ",", "the", "C", "-", "terminal", "verprolin", "-", "cofilin", "-", "acidic", "domain", "was", "shown", "to", "be", "essential", "for", "the", "regulation", "of", "actin", "cytoskeleton", "." ]	[ "Gene/protein/RNA" ]
verprolin is a Gene/protein/RNA, cofilin is a Gene/protein/RNA, actin is a Gene/protein/RNA	280_task1	Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please typing these entity words according to sentence: verprolin, cofilin, actin Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]	First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.	[ "First", ",", "the", "C", "-", "terminal", "verprolin", "-", "cofilin", "-", "acidic", "domain", "was", "shown", "to", "be", "essential", "for", "the", "regulation", "of", "actin", "cytoskeleton", "." ]	[ "Gene/protein/RNA" ]
verprolin, cofilin, actin	280_task2	Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]	First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.	[ "First", ",", "the", "C", "-", "terminal", "verprolin", "-", "cofilin", "-", "acidic", "domain", "was", "shown", "to", "be", "essential", "for", "the", "regulation", "of", "actin", "cytoskeleton", "." ]	[ "Gene/protein/RNA" ]
interleukin 2 is a Protein, Ca2+/calmodulin kinase type IV / Gr is a Protein, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr is a Protein, CaMKIV / Gr is a Protein, p21ras is a Protein, CaMKIV/ Gr is a Protein, c - fos is a Protein, p21ras is a Protein, interleukin 2 is a Protein, CaMKIV / Gr is a Protein, CaMKIV / Gr is a Protein	601_task0	Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.	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interleukin 2 is a Protein, Ca2+/calmodulin kinase type IV / Gr is a Protein, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr is a Protein, CaMKIV / Gr is a Protein, p21ras is a Protein, CaMKIV/ Gr is a Protein, c - fos is a Protein, p21ras is a Protein, interleukin 2 is a Protein, CaMKIV / Gr is a Protein, CaMKIV / Gr is a Protein	601_task1	Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please typing these entity words according to sentence: interleukin 2, Ca2+/calmodulin kinase type IV / Gr, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr, CaMKIV / Gr, p21ras, CaMKIV/ Gr, c - fos, p21ras, interleukin 2, CaMKIV / Gr, CaMKIV / Gr Options: Protein	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.	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interleukin 2, Ca2+/calmodulin kinase type IV / Gr, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr, CaMKIV / Gr, p21ras, CaMKIV/ Gr, c - fos, p21ras, interleukin 2, CaMKIV / Gr, CaMKIV / Gr	601_task2	Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.	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Arg389Gly is a GENE-N, beta1-adrenoceptor is a GENE-Y, catecholamine is a CHEMICAL, renin is a GENE-Y	16325050_task0	Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.	[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Arg389Gly is a GENE-N, beta1-adrenoceptor is a GENE-Y, catecholamine is a CHEMICAL, renin is a GENE-Y	16325050_task1	Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please typing these entity words according to sentence: Arg389Gly, beta1-adrenoceptor, catecholamine, renin Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.	[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Arg389Gly, beta1-adrenoceptor, catecholamine, renin	16325050_task2	Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please extract entity words from the input sentence	[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.	[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]	[ "GENE-Y", "CHEMICAL", "GENE-N" ]
mdm2 is a protein, p53 is a protein, p53 is a protein, ubiquitin is a protein-family	1.0alpha7.train.840_task0	Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein	[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).	[ "Binding", "of", " ", "mdm2", "to", " ", "p53", "also", " ", "targets", "p53", "for", "degradation", "through", " ", "ubiquitin", "-", "mediated", "pathways", "(", "19", ",", " ", "20", ")", "." ]	[ "protein-family", "protein" ]
mdm2 is a protein, p53 is a protein, p53 is a protein, ubiquitin is a protein-family	1.0alpha7.train.840_task1	Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please typing these entity words according to sentence: mdm2, p53, p53, ubiquitin Options: protein-family, protein	[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).	[ "Binding", "of", " ", "mdm2", "to", " ", "p53", "also", " ", "targets", "p53", "for", "degradation", "through", " ", "ubiquitin", "-", "mediated", "pathways", "(", "19", ",", " ", "20", ")", "." ]	[ "protein-family", "protein" ]
mdm2, p53, p53, ubiquitin	1.0alpha7.train.840_task2	Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).	[ "Binding", "of", " ", "mdm2", "to", " ", "p53", "also", " ", "targets", "p53", "for", "degradation", "through", " ", "ubiquitin", "-", "mediated", "pathways", "(", "19", ",", " ", "20", ")", "." ]	[ "protein-family", "protein" ]
hyaluronic acid is a Intervention_Pharmacological, triamcinolone hexacetonide is a Intervention_Pharmacological, inflammatory knee osteoarthritis is a Participant_Condition, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ) is a Intervention_Pharmacological, 63 patients is a Participant_Sample-size, 24 male is a Participant_Sex, 39 female is a Participant_Sex, age 70.5 years is a Participant_Age, bilateral symptomatic knee osteoarthritis with effusion is a Participant_Condition, HA injections is a Intervention_Pharmacological, 20 mg is a Intervention_Control, placebo ( saline ) injections is a Intervention_Control, visual analog scores ( VAS ) for pain is a Outcome_Pain, duration of stiffness is a Outcome_Physical, range of movement is a Outcome_Physical, joint effusion is a Outcome_Physical, local heat is a Outcome_Physical, synovial thickening is a Outcome_Physical, joint - line and periarticular tenderness is a Outcome_Physical, pain on a self - selected activity assessed by Vas is a Outcome_Pain	87292_task0	Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Pain, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .	[ "Intra", "-", "articular", "hyaluronic", "acid", "compared", "to", "intra", "-", "articular", "triamcinolone", "hexacetonide", "in", "inflammatory", "knee", "osteoarthritis", ".", "The", "aim", "of", "this", "study", "was", "to", "determine", "the", "comparative", "efficacy", "and", "safety", "of", "intra", "-", "articular", "(", "i", "/", "a", ")", "triamcinolone", ".", "hexacetonide", "(", "TH", ")", "and", "i", "/", "a", "hyaluronic", "acid", "(", "HA", ")", "in", "inflammatory", "knee", "osteoarthritis", ".", "A", "randomized", "double", "-", "blind", "comparative", "trail", "was", "carried", "out", "in", "a", "rheumatology", "outpatient", "department", ".", "There", "were", "63", "patients", "(", "24", "male", ",", "39", "female", ",", "mean", "age", "70.5", "years", ")", "with", "bilateral", "symptomatic", "knee", "osteoarthritis", "with", "effusion", ".", "Each", "was", "given", "five", "HA", "injections", "at", "weekly", "intervals", ";", "or", "20", "mg", "TH", "followed", "by", "four", "placebo", "(", "saline", ")", "injections", ".", "Patients", "were", "examined", "weekly", "during", "the", "treatment", "period", "and", "then", "at", "monthly", "intervals", "for", "a", "further", "6", "months", ".", "Assessment", "included", "recording", "of", ":", "visual", "analog", "scores", "(", "VAS", ")", "for", "pain", ";", "duration", "of", "stiffness", ";", "range", "of", "movement", ";", "joint", "effusion", ";", "local", "heat", ";", "synovial", "thickening", ";", "joint", "-", "line", "and", "periarticular", "tenderness", ".", "The", "principal", "outcome", "measure", "was", "pain", "on", "a", "self", "-", "selected", "activity", "assessed", "by", "Vas", ".", "The", "two", "groups", "were", "comparable", "at", "entry", "and", "no", "significant", "differences", "between", "the", "groups", "developed", "at", "any", "time", "during", "the", "treatment", "period", ".", "However", ",", "there", "was", "a", "high", "drop", "-", "out", "rate", "and", "intention", "to", "treat", "analysis", "failed", "to", "demonstrate", "statistically", "significant", "differences", "between", "the", "groups", ".", "In", "patients", "remaining", "in", "the", "study", ",", "significantly", "less", "pain", "was", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "HA", ".", "We", "could", "not", ",", "however", ",", "demonstrate", "significant", "differences", "between", "the", "placebo", "and", "active", "treatments", ".", "HA", "may", "therefore", "be", "a", "useful", "additional", "therapy", "for", "symptomatic", "knee", "osteoarthritis", "and", "may", "have", "a", "long", "duration", "of", "action", "." ]	[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]
hyaluronic acid is a Intervention_Pharmacological, triamcinolone hexacetonide is a Intervention_Pharmacological, inflammatory knee osteoarthritis is a Participant_Condition, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ) is a Intervention_Pharmacological, 63 patients is a Participant_Sample-size, 24 male is a Participant_Sex, 39 female is a Participant_Sex, age 70.5 years is a Participant_Age, bilateral symptomatic knee osteoarthritis with effusion is a Participant_Condition, HA injections is a Intervention_Pharmacological, 20 mg is a Intervention_Control, placebo ( saline ) injections is a Intervention_Control, visual analog scores ( VAS ) for pain is a Outcome_Pain, duration of stiffness is a Outcome_Physical, range of movement is a Outcome_Physical, joint effusion is a Outcome_Physical, local heat is a Outcome_Physical, synovial thickening is a Outcome_Physical, joint - line and periarticular tenderness is a Outcome_Physical, pain on a self - selected activity assessed by Vas is a Outcome_Pain	87292_task1	Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please typing these entity words according to sentence: hyaluronic acid, triamcinolone hexacetonide, inflammatory knee osteoarthritis, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ), 63 patients, 24 male, 39 female, age 70.5 years, bilateral symptomatic knee osteoarthritis with effusion, HA injections, 20 mg, placebo ( saline ) injections, visual analog scores ( VAS ) for pain, duration of stiffness, range of movement, joint effusion, local heat, synovial thickening, joint - line and periarticular tenderness, pain on a self - selected activity assessed by Vas Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Pain, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .	[ "Intra", "-", "articular", "hyaluronic", "acid", "compared", "to", "intra", "-", "articular", "triamcinolone", "hexacetonide", "in", "inflammatory", "knee", "osteoarthritis", ".", "The", "aim", "of", "this", "study", "was", "to", "determine", "the", "comparative", "efficacy", "and", "safety", "of", "intra", "-", "articular", "(", "i", "/", "a", ")", "triamcinolone", ".", "hexacetonide", "(", "TH", ")", "and", "i", "/", "a", "hyaluronic", "acid", "(", "HA", ")", "in", "inflammatory", "knee", "osteoarthritis", ".", "A", "randomized", "double", "-", "blind", "comparative", "trail", "was", "carried", "out", "in", "a", "rheumatology", "outpatient", "department", ".", "There", "were", "63", "patients", "(", "24", "male", ",", "39", "female", ",", "mean", "age", "70.5", "years", ")", "with", "bilateral", "symptomatic", "knee", "osteoarthritis", "with", "effusion", ".", "Each", "was", "given", "five", "HA", "injections", "at", "weekly", "intervals", ";", "or", "20", "mg", "TH", "followed", "by", "four", "placebo", "(", "saline", ")", "injections", ".", "Patients", "were", "examined", "weekly", "during", "the", "treatment", "period", "and", "then", "at", "monthly", "intervals", "for", "a", "further", "6", "months", ".", "Assessment", "included", "recording", "of", ":", "visual", "analog", "scores", "(", "VAS", ")", "for", "pain", ";", "duration", "of", "stiffness", ";", "range", "of", "movement", ";", "joint", "effusion", ";", "local", "heat", ";", "synovial", "thickening", ";", "joint", "-", "line", "and", "periarticular", "tenderness", ".", "The", "principal", "outcome", "measure", "was", "pain", "on", "a", "self", "-", "selected", "activity", "assessed", "by", "Vas", ".", "The", "two", "groups", "were", "comparable", "at", "entry", "and", "no", "significant", "differences", "between", "the", "groups", "developed", "at", "any", "time", "during", "the", "treatment", "period", ".", "However", ",", "there", "was", "a", "high", "drop", "-", "out", "rate", "and", "intention", "to", "treat", "analysis", "failed", "to", "demonstrate", "statistically", "significant", "differences", "between", "the", "groups", ".", "In", "patients", "remaining", "in", "the", "study", ",", "significantly", "less", "pain", "was", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "HA", ".", "We", "could", "not", ",", "however", ",", "demonstrate", "significant", "differences", "between", "the", "placebo", "and", "active", "treatments", ".", "HA", "may", "therefore", "be", "a", "useful", "additional", "therapy", "for", "symptomatic", "knee", "osteoarthritis", "and", "may", "have", "a", "long", "duration", "of", "action", "." ]	[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]
hyaluronic acid, triamcinolone hexacetonide, inflammatory knee osteoarthritis, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ), 63 patients, 24 male, 39 female, age 70.5 years, bilateral symptomatic knee osteoarthritis with effusion, HA injections, 20 mg, placebo ( saline ) injections, visual analog scores ( VAS ) for pain, duration of stiffness, range of movement, joint effusion, local heat, synovial thickening, joint - line and periarticular tenderness, pain on a self - selected activity assessed by Vas	87292_task2	Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "B-Participant_Sex", "I-Participant_Sex", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "I-Outcome_Pain", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .	[ "Intra", "-", "articular", "hyaluronic", "acid", "compared", "to", "intra", "-", "articular", "triamcinolone", "hexacetonide", "in", "inflammatory", "knee", "osteoarthritis", ".", "The", "aim", "of", "this", "study", "was", "to", "determine", "the", "comparative", "efficacy", "and", "safety", "of", "intra", "-", "articular", "(", "i", "/", "a", ")", "triamcinolone", ".", "hexacetonide", "(", "TH", ")", "and", "i", "/", "a", "hyaluronic", "acid", "(", "HA", ")", "in", "inflammatory", "knee", "osteoarthritis", ".", "A", "randomized", "double", "-", "blind", "comparative", "trail", "was", "carried", "out", "in", "a", "rheumatology", "outpatient", "department", ".", "There", "were", "63", "patients", "(", "24", "male", ",", "39", "female", ",", "mean", "age", "70.5", "years", ")", "with", "bilateral", "symptomatic", "knee", "osteoarthritis", "with", "effusion", ".", "Each", "was", "given", "five", "HA", "injections", "at", "weekly", "intervals", ";", "or", "20", "mg", "TH", "followed", "by", "four", "placebo", "(", "saline", ")", "injections", ".", "Patients", "were", "examined", "weekly", "during", "the", "treatment", "period", "and", "then", "at", "monthly", "intervals", "for", "a", "further", "6", "months", ".", "Assessment", "included", "recording", "of", ":", "visual", "analog", "scores", "(", "VAS", ")", "for", "pain", ";", "duration", "of", "stiffness", ";", "range", "of", "movement", ";", "joint", "effusion", ";", "local", "heat", ";", "synovial", "thickening", ";", "joint", "-", "line", "and", "periarticular", "tenderness", ".", "The", "principal", "outcome", "measure", "was", "pain", "on", "a", "self", "-", "selected", "activity", "assessed", "by", "Vas", ".", "The", "two", "groups", "were", "comparable", "at", "entry", "and", "no", "significant", "differences", "between", "the", "groups", "developed", "at", "any", "time", "during", "the", "treatment", "period", ".", "However", ",", "there", "was", "a", "high", "drop", "-", "out", "rate", "and", "intention", "to", "treat", "analysis", "failed", "to", "demonstrate", "statistically", "significant", "differences", "between", "the", "groups", ".", "In", "patients", "remaining", "in", "the", "study", ",", "significantly", "less", "pain", "was", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "experienced", "by", "the", "HA", "group", "during", "the", "6", "month", "follow", "-", "up", "period", ".", "Other", "parameters", "showed", "a", "similar", "trend", "in", "favor", "of", "HA", ".", "We", "could", "not", ",", "however", ",", "demonstrate", "significant", "differences", "between", "the", "placebo", "and", "active", "treatments", ".", "HA", "may", "therefore", "be", "a", "useful", "additional", "therapy", "for", "symptomatic", "knee", "osteoarthritis", "and", "may", "have", "a", "long", "duration", "of", "action", "." ]	[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]
surgery is an umlsterm, patients is an umlsterm, plan is an umlsterm, reintubation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, carcinoma is an umlsterm, hypopharynx is an umlsterm, risk is an umlsterm, intubation is an umlsterm, general anaesthesia is an umlsterm, patients is an umlsterm, acute abdomen is an umlsterm, ileus is an umlsterm, trachea is an umlsterm, fiberoptic is an umlsterm, reintubation is an umlsterm	DerAnaesthesist.40430618.eng.abstr_task0	Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .	[ "Securing", "the", "airway", "following", "surgery", "can", "be", "a", "problem", "in", "certain", "patients", ".", "Preparation", ",", "therefore", ",", "should", "include", "a", "plan", "for", "safe", "reintubation", ",", "if", "necessary", ".", "We", "report", "two", "patients", "with", "a", "difficult", "airway", "(", "recurrent", "thyroid", "carcinoma", ",", "inoperable", "carcinoma", "of", "the", "hypopharynx", ")", "who", "were", "at", "a", "high", "risk", "for", "intubation", "under", "general", "anaesthesia", ".", "In", "addition", ",", "one", "of", "the", "patients", "suffered", "from", "an", "acute", "abdomen", "and", "ileus", ".", "We", "used", "a", "guidewire", "placed", "into", "the", "trachea", "via", "a", "fiberscope", "to", "facilitate", "fiberoptic", "reintubation", "." ]	[ "umlsterm" ]
surgery is an umlsterm, patients is an umlsterm, plan is an umlsterm, reintubation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, carcinoma is an umlsterm, hypopharynx is an umlsterm, risk is an umlsterm, intubation is an umlsterm, general anaesthesia is an umlsterm, patients is an umlsterm, acute abdomen is an umlsterm, ileus is an umlsterm, trachea is an umlsterm, fiberoptic is an umlsterm, reintubation is an umlsterm	DerAnaesthesist.40430618.eng.abstr_task1	Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please typing these entity words according to sentence: surgery, patients, plan, reintubation, patients, thyroid, carcinoma, carcinoma, hypopharynx, risk, intubation, general anaesthesia, patients, acute abdomen, ileus, trachea, fiberoptic, reintubation Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .	[ "Securing", "the", "airway", "following", "surgery", "can", "be", "a", "problem", "in", "certain", "patients", ".", "Preparation", ",", "therefore", ",", "should", "include", "a", "plan", "for", "safe", "reintubation", ",", "if", "necessary", ".", "We", "report", "two", "patients", "with", "a", "difficult", "airway", "(", "recurrent", "thyroid", "carcinoma", ",", "inoperable", "carcinoma", "of", "the", "hypopharynx", ")", "who", "were", "at", "a", "high", "risk", "for", "intubation", "under", "general", "anaesthesia", ".", "In", "addition", ",", "one", "of", "the", "patients", "suffered", "from", "an", "acute", "abdomen", "and", "ileus", ".", "We", "used", "a", "guidewire", "placed", "into", "the", "trachea", "via", "a", "fiberscope", "to", "facilitate", "fiberoptic", "reintubation", "." ]	[ "umlsterm" ]
surgery, patients, plan, reintubation, patients, thyroid, carcinoma, carcinoma, hypopharynx, risk, intubation, general anaesthesia, patients, acute abdomen, ileus, trachea, fiberoptic, reintubation	DerAnaesthesist.40430618.eng.abstr_task2	Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .	[ "Securing", "the", "airway", "following", "surgery", "can", "be", "a", "problem", "in", "certain", "patients", ".", "Preparation", ",", "therefore", ",", "should", "include", "a", "plan", "for", "safe", "reintubation", ",", "if", "necessary", ".", "We", "report", "two", "patients", "with", "a", "difficult", "airway", "(", "recurrent", "thyroid", "carcinoma", ",", "inoperable", "carcinoma", "of", "the", "hypopharynx", ")", "who", "were", "at", "a", "high", "risk", "for", "intubation", "under", "general", "anaesthesia", ".", "In", "addition", ",", "one", "of", "the", "patients", "suffered", "from", "an", "acute", "abdomen", "and", "ileus", ".", "We", "used", "a", "guidewire", "placed", "into", "the", "trachea", "via", "a", "fiberscope", "to", "facilitate", "fiberoptic", "reintubation", "." ]	[ "umlsterm" ]
contrast is an umlsterm, humeral fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, injury is an umlsterm, old is an umlsterm, patient is an umlsterm, fracture is an umlsterm, osteoporosis is an umlsterm, multi - morbidity is an umlsterm, classification is an umlsterm, head is an umlsterm, fractures is an umlsterm, fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, surgical procedures is an umlsterm, head is an umlsterm, treatment is an umlsterm, choice is an umlsterm, patients is an umlsterm, morbidity is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, fractures is an umlsterm, recommendations is an umlsterm, elderly is an umlsterm, open is an umlsterm, postoperative is an umlsterm, treatment is an umlsterm, tissue is an umlsterm, injuries is an umlsterm, patients is an umlsterm, surgical is an umlsterm, proximal humeral fractures is an umlsterm, surgical treatment is an umlsterm	DerOrthopaede.00290327.eng.abstr_task0	Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .	[ "In", "contrast", "to", "distal", "humeral", "fractures", ",", "humeral", "head", "fractures", "represent", "a", "common", "injury", "to", "the", "old", "patient", ".", "For", "both", "fracture", "localizations", "osteoporosis", "and", "multi", "-", "morbidity", "are", "of", "significant", "importance", ".", "The", "classification", "for", "humeral", "head", "fractures", "in", "one-", ",", "two-", ",", "three-", "and", "four", "-", "part", "fractures", "is", "generally", "accepted", ".", "Valgus", "impacted", "head", "fractures", "as", "well", "as", "head", "-", "splitting", "fractures", "are", "considered", "a", "seperate", "entity", ".", "In", "none", "or", "minimally", "displaced", "fractures", "good", "functional", "results", "are", "achieved", "by", "conservative", "means", ".", "Although", "numerous", "therapeutical", "procdure", "are", "offered", "in", "the", "treatment", "of", "displaced", "fractures", "of", "the", "proximal", "humerus", "the", "result", "are", "often", "disappointing", ".", "Generally", ",", "minimal", "invasive", "surgical", "procedures", "should", "be", "preferred", ".", "However", ",", "in", "dislocated", "multi", "-", "part", "fractures", "a", "primary", "humeral", "head", "replacement", "is", "often", "the", "treatment", "of", "choice", ".", "In", "patients", "with", "mutifarious", "morbidity", "a", "conservative", "treatment", "is", "always", "to", "be", "included", "into", "the", "therapeutical", "considerations", ".", "Distal", "fractures", "of", "the", "humerus", "are", "classified", "into", "extraarticular", ",", "intraarticular", "unicondylar", "and", "intraarticular", "bicondylar", "fractures", ".", "The", "therapeutical", "recommendations", ",", "also", "in", "the", "elderly", ",", "is", "relatively", "homogenous", ":", "primary", "open", "reduction", "and", "internal", "fixation", "(", "ORIF", ")", "should", "be", "carried", "out", "aiming", "for", "an", "early", "postoperative", "functional", "treatment", ".", "Depending", "from", "soft", "tissue", "conditions", "and", "accompanying", "injuries", "the", "functional", "results", "are", "often", "good", "or", "moderate", "and", "are", "generally", "comparable", "to", "those", "of", "younger", "patients", ".", "Following", "a", "correct", "indication", "for", "surgical", "intervention", "the", "main", "priority", "for", "both", "distal", "and", "proximal", "humeral", "fractures", "is", "an", "early", "definitive", "surgical", "treatment", "." ]	[ "umlsterm" ]
contrast is an umlsterm, humeral fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, injury is an umlsterm, old is an umlsterm, patient is an umlsterm, fracture is an umlsterm, osteoporosis is an umlsterm, multi - morbidity is an umlsterm, classification is an umlsterm, head is an umlsterm, fractures is an umlsterm, fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, surgical procedures is an umlsterm, head is an umlsterm, treatment is an umlsterm, choice is an umlsterm, patients is an umlsterm, morbidity is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, fractures is an umlsterm, recommendations is an umlsterm, elderly is an umlsterm, open is an umlsterm, postoperative is an umlsterm, treatment is an umlsterm, tissue is an umlsterm, injuries is an umlsterm, patients is an umlsterm, surgical is an umlsterm, proximal humeral fractures is an umlsterm, surgical treatment is an umlsterm	DerOrthopaede.00290327.eng.abstr_task1	Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please typing these entity words according to sentence: contrast, humeral fractures, head, fractures, injury, old, patient, fracture, osteoporosis, multi - morbidity, classification, head, fractures, fractures, head, fractures, treatment, fractures, humerus, surgical procedures, head, treatment, choice, patients, morbidity, treatment, fractures, humerus, fractures, recommendations, elderly, open, postoperative, treatment, tissue, injuries, patients, surgical, proximal humeral fractures, surgical treatment Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .	[ "In", "contrast", "to", "distal", "humeral", "fractures", ",", "humeral", "head", "fractures", "represent", "a", "common", "injury", "to", "the", "old", "patient", ".", "For", "both", "fracture", "localizations", "osteoporosis", "and", "multi", "-", "morbidity", "are", "of", "significant", "importance", ".", "The", "classification", "for", "humeral", "head", "fractures", "in", "one-", ",", "two-", ",", "three-", "and", "four", "-", "part", "fractures", "is", "generally", "accepted", ".", "Valgus", "impacted", "head", "fractures", "as", "well", "as", "head", "-", "splitting", "fractures", "are", "considered", "a", "seperate", "entity", ".", "In", "none", "or", "minimally", "displaced", "fractures", "good", "functional", "results", "are", "achieved", "by", "conservative", "means", ".", "Although", "numerous", "therapeutical", "procdure", "are", "offered", "in", "the", "treatment", "of", "displaced", "fractures", "of", "the", "proximal", "humerus", "the", "result", "are", "often", "disappointing", ".", "Generally", ",", "minimal", "invasive", "surgical", "procedures", "should", "be", "preferred", ".", "However", ",", "in", "dislocated", "multi", "-", "part", "fractures", "a", "primary", "humeral", "head", "replacement", "is", "often", "the", "treatment", "of", "choice", ".", "In", "patients", "with", "mutifarious", "morbidity", "a", "conservative", "treatment", "is", "always", "to", "be", "included", "into", "the", "therapeutical", "considerations", ".", "Distal", "fractures", "of", "the", "humerus", "are", "classified", "into", "extraarticular", ",", "intraarticular", "unicondylar", "and", "intraarticular", "bicondylar", "fractures", ".", "The", "therapeutical", "recommendations", ",", "also", "in", "the", "elderly", ",", "is", "relatively", "homogenous", ":", "primary", "open", "reduction", "and", "internal", "fixation", "(", "ORIF", ")", "should", "be", "carried", "out", "aiming", "for", "an", "early", "postoperative", "functional", "treatment", ".", "Depending", "from", "soft", "tissue", "conditions", "and", "accompanying", "injuries", "the", "functional", "results", "are", "often", "good", "or", "moderate", "and", "are", "generally", "comparable", "to", "those", "of", "younger", "patients", ".", "Following", "a", "correct", "indication", "for", "surgical", "intervention", "the", "main", "priority", "for", "both", "distal", "and", "proximal", "humeral", "fractures", "is", "an", "early", "definitive", "surgical", "treatment", "." ]	[ "umlsterm" ]
contrast, humeral fractures, head, fractures, injury, old, patient, fracture, osteoporosis, multi - morbidity, classification, head, fractures, fractures, head, fractures, treatment, fractures, humerus, surgical procedures, head, treatment, choice, patients, morbidity, treatment, fractures, humerus, fractures, recommendations, elderly, open, postoperative, treatment, tissue, injuries, patients, surgical, proximal humeral fractures, surgical treatment	DerOrthopaede.00290327.eng.abstr_task2	Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .	[ "In", "contrast", "to", "distal", "humeral", "fractures", ",", "humeral", "head", "fractures", "represent", "a", "common", "injury", "to", "the", "old", "patient", ".", "For", "both", "fracture", "localizations", "osteoporosis", "and", "multi", "-", "morbidity", "are", "of", "significant", "importance", ".", "The", "classification", "for", "humeral", "head", "fractures", "in", "one-", ",", "two-", ",", "three-", "and", "four", "-", "part", "fractures", "is", "generally", "accepted", ".", "Valgus", "impacted", "head", "fractures", "as", "well", "as", "head", "-", "splitting", "fractures", "are", "considered", "a", "seperate", "entity", ".", "In", "none", "or", "minimally", "displaced", "fractures", "good", "functional", "results", "are", "achieved", "by", "conservative", "means", ".", "Although", "numerous", "therapeutical", "procdure", "are", "offered", "in", "the", "treatment", "of", "displaced", "fractures", "of", "the", "proximal", "humerus", "the", "result", "are", "often", "disappointing", ".", "Generally", ",", "minimal", "invasive", "surgical", "procedures", "should", "be", "preferred", ".", "However", ",", "in", "dislocated", "multi", "-", "part", "fractures", "a", "primary", "humeral", "head", "replacement", "is", "often", "the", "treatment", "of", "choice", ".", "In", "patients", "with", "mutifarious", "morbidity", "a", "conservative", "treatment", "is", "always", "to", "be", "included", "into", "the", "therapeutical", "considerations", ".", "Distal", "fractures", "of", "the", "humerus", "are", "classified", "into", "extraarticular", ",", "intraarticular", "unicondylar", "and", "intraarticular", "bicondylar", "fractures", ".", "The", "therapeutical", "recommendations", ",", "also", "in", "the", "elderly", ",", "is", "relatively", "homogenous", ":", "primary", "open", "reduction", "and", "internal", "fixation", "(", "ORIF", ")", "should", "be", "carried", "out", "aiming", "for", "an", "early", "postoperative", "functional", "treatment", ".", "Depending", "from", "soft", "tissue", "conditions", "and", "accompanying", "injuries", "the", "functional", "results", "are", "often", "good", "or", "moderate", "and", "are", "generally", "comparable", "to", "those", "of", "younger", "patients", ".", "Following", "a", "correct", "indication", "for", "surgical", "intervention", "the", "main", "priority", "for", "both", "distal", "and", "proximal", "humeral", "fractures", "is", "an", "early", "definitive", "surgical", "treatment", "." ]	[ "umlsterm" ]
prospective study is an umlsterm, microcatheter is an umlsterm, spinal anaesthesia is an umlsterm, technique is an umlsterm, trauma is an umlsterm, patients is an umlsterm	DerAnaesthesist.70460938.eng.abstr_task0	Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .	[ "In", "this", "prospective", "study", "we", "investigated", "the", "efficacy", "of", "microcatheter", "spinal", "anaesthesia", "in", "comparison", "with", "a", "combined", "spinal", "-", "epidural", "technique", "in", "trauma", "patients", "." ]	[ "umlsterm" ]
prospective study is an umlsterm, microcatheter is an umlsterm, spinal anaesthesia is an umlsterm, technique is an umlsterm, trauma is an umlsterm, patients is an umlsterm	DerAnaesthesist.70460938.eng.abstr_task1	Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please typing these entity words according to sentence: prospective study, microcatheter, spinal anaesthesia, technique, trauma, patients Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .	[ "In", "this", "prospective", "study", "we", "investigated", "the", "efficacy", "of", "microcatheter", "spinal", "anaesthesia", "in", "comparison", "with", "a", "combined", "spinal", "-", "epidural", "technique", "in", "trauma", "patients", "." ]	[ "umlsterm" ]
prospective study, microcatheter, spinal anaesthesia, technique, trauma, patients	DerAnaesthesist.70460938.eng.abstr_task2	Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .	[ "In", "this", "prospective", "study", "we", "investigated", "the", "efficacy", "of", "microcatheter", "spinal", "anaesthesia", "in", "comparison", "with", "a", "combined", "spinal", "-", "epidural", "technique", "in", "trauma", "patients", "." ]	[ "umlsterm" ]
[ Metastatic breast cancer is a Participant_Condition, tamoxifen is a Intervention_Pharmacological, medroxyprogesterone acetate is a Intervention_Pharmacological, Seventy - nine is a Participant_Sample-size, histologically proven disseminated breast cancer is a Participant_Condition, never treated before with additive hormonal therapy is a Participant_Condition, tamoxifen ( TAM ) is a Intervention_Pharmacological, mean is a Outcome_Physical, duration of therapeutic response is a Outcome_Other	78518_task0	Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .	[ "[", "Metastatic", "breast", "cancer", ":", "a", "comparative", "study", "of", "the", "efficacy", "of", "tamoxifen", "and", "the", "sequential", "administration", "of", "tamoxifen", "and", "medroxyprogesterone", "acetate", "]", ".", "Seventy", "-", "nine", "patients", "with", "an", "histologically", "proven", "disseminated", "breast", "cancer", ",", "never", "treated", "before", "with", "additive", "hormonal", "therapy", ",", "entered", "into", "a", "randomized", "trial", "between", "june", "1981", "and", "december", "1982", ".", "In", "the", "first", "group", "44", "patients", "were", "given", "continually", "a", "daily", "dose", "of", "tamoxifen", "(", "TAM", ")", "of", "20", "mg", "/", "m2", ".", "In", "the", "2nd", "group", "35", "patients", "were", "given", "a", "daily", "dose", "of", "TAM", "of", "20", "mg", "/", "m2", "for", "15", "days", "and", "then", "an", "oral", "daily", "dose", "of", "medroxyprogesterone", "acetate", "of", "350", "mg", "/", "m2", "for", "the", "next", "15", "days", ".", "In", "both", "groups", "I", "and", "II", ",", "the", "treatment", "was", "stopped", "at", "the", "first", "manifestation", "of", "progression", "of", "the", "disease", ".", "The", "hormonal", "receptor", "status", "was", "determined", "in", "30", "patients", "of", "the", "group", "I", "and", "23", "patients", "of", "the", "group", "II", ".", "An", "objective", "response", "to", "treatment", "was", "observed", "in", "48", "per", "cent", "of", "the", "patients", "of", "the", "group", "I", "and", "60", "per", "cent", "of", "the", "group", "II", ".", "This", "difference", "is", "not", "significant", "(", "X2", "=", "1,05", ")", ".", "However", ",", "the", "mean", "duration", "of", "therapeutic", "response", "is", "significantly", "higher", "in", "the", "group", "II", "(", "p", "=", "0,01", ")", "." ]	[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]
[ Metastatic breast cancer is a Participant_Condition, tamoxifen is a Intervention_Pharmacological, medroxyprogesterone acetate is a Intervention_Pharmacological, Seventy - nine is a Participant_Sample-size, histologically proven disseminated breast cancer is a Participant_Condition, never treated before with additive hormonal therapy is a Participant_Condition, tamoxifen ( TAM ) is a Intervention_Pharmacological, mean is a Outcome_Physical, duration of therapeutic response is a Outcome_Other	78518_task1	Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please typing these entity words according to sentence: [ Metastatic breast cancer, tamoxifen, medroxyprogesterone acetate, Seventy - nine, histologically proven disseminated breast cancer, never treated before with additive hormonal therapy, tamoxifen ( TAM ), mean, duration of therapeutic response Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .	[ "[", "Metastatic", "breast", "cancer", ":", "a", "comparative", "study", "of", "the", "efficacy", "of", "tamoxifen", "and", "the", "sequential", "administration", "of", "tamoxifen", "and", "medroxyprogesterone", "acetate", "]", ".", "Seventy", "-", "nine", "patients", "with", "an", "histologically", "proven", "disseminated", "breast", "cancer", ",", "never", "treated", "before", "with", "additive", "hormonal", "therapy", ",", "entered", "into", "a", "randomized", "trial", "between", "june", "1981", "and", "december", "1982", ".", "In", "the", "first", "group", "44", "patients", "were", "given", "continually", "a", "daily", "dose", "of", "tamoxifen", "(", "TAM", ")", "of", "20", "mg", "/", "m2", ".", "In", "the", "2nd", "group", "35", "patients", "were", "given", "a", "daily", "dose", "of", "TAM", "of", "20", "mg", "/", "m2", "for", "15", "days", "and", "then", "an", "oral", "daily", "dose", "of", "medroxyprogesterone", "acetate", "of", "350", "mg", "/", "m2", "for", "the", "next", "15", "days", ".", "In", "both", "groups", "I", "and", "II", ",", "the", "treatment", "was", "stopped", "at", "the", "first", "manifestation", "of", "progression", "of", "the", "disease", ".", "The", "hormonal", "receptor", "status", "was", "determined", "in", "30", "patients", "of", "the", "group", "I", "and", "23", "patients", "of", "the", "group", "II", ".", "An", "objective", "response", "to", "treatment", "was", "observed", "in", "48", "per", "cent", "of", "the", "patients", "of", "the", "group", "I", "and", "60", "per", "cent", "of", "the", "group", "II", ".", "This", "difference", "is", "not", "significant", "(", "X2", "=", "1,05", ")", ".", "However", ",", "the", "mean", "duration", "of", "therapeutic", "response", "is", "significantly", "higher", "in", "the", "group", "II", "(", "p", "=", "0,01", ")", "." ]	[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]
[ Metastatic breast cancer, tamoxifen, medroxyprogesterone acetate, Seventy - nine, histologically proven disseminated breast cancer, never treated before with additive hormonal therapy, tamoxifen ( TAM ), mean, duration of therapeutic response	78518_task2	Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please extract entity words from the input sentence	[ "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .	[ "[", "Metastatic", "breast", "cancer", ":", "a", "comparative", "study", "of", "the", "efficacy", "of", "tamoxifen", "and", "the", "sequential", "administration", "of", "tamoxifen", "and", "medroxyprogesterone", "acetate", "]", ".", "Seventy", "-", "nine", "patients", "with", "an", "histologically", "proven", "disseminated", "breast", "cancer", ",", "never", "treated", "before", "with", "additive", "hormonal", "therapy", ",", "entered", "into", "a", "randomized", "trial", "between", "june", "1981", "and", "december", "1982", ".", "In", "the", "first", "group", "44", "patients", "were", "given", "continually", "a", "daily", "dose", "of", "tamoxifen", "(", "TAM", ")", "of", "20", "mg", "/", "m2", ".", "In", "the", "2nd", "group", "35", "patients", "were", "given", "a", "daily", "dose", "of", "TAM", "of", "20", "mg", "/", "m2", "for", "15", "days", "and", "then", "an", "oral", "daily", "dose", "of", "medroxyprogesterone", "acetate", "of", "350", "mg", "/", "m2", "for", "the", "next", "15", "days", ".", "In", "both", "groups", "I", "and", "II", ",", "the", "treatment", "was", "stopped", "at", "the", "first", "manifestation", "of", "progression", "of", "the", "disease", ".", "The", "hormonal", "receptor", "status", "was", "determined", "in", "30", "patients", "of", "the", "group", "I", "and", "23", "patients", "of", "the", "group", "II", ".", "An", "objective", "response", "to", "treatment", "was", "observed", "in", "48", "per", "cent", "of", "the", "patients", "of", "the", "group", "I", "and", "60", "per", "cent", "of", "the", "group", "II", ".", "This", "difference", "is", "not", "significant", "(", "X2", "=", "1,05", ")", ".", "However", ",", "the", "mean", "duration", "of", "therapeutic", "response", "is", "significantly", "higher", "in", "the", "group", "II", "(", "p", "=", "0,01", ")", "." ]	[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]
beta - like globin is a Protein, chloramphenicol acetyltransferase is a Protein, CAT is a Protein, CAT is a Protein, CAT is a Protein	245_task0	Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.	[ "Transcription", "of", "the", "hypersensitive", "site", "HS2", "enhancer", "in", "erythroid", "cells", ".", "\n", "In", "the", "human", "genome", ",", "the", "erythroid", "-", "specific", "hypersensitive", "site", "HS2", "enhancer", "regulates", "the", "transcription", "of", "the", "downstream", "beta", "-", "like", "globin", "genes", "10", "-", "50", "kilobases", "away", ".", "The", "mechanism", "of", "HS2", "enhancer", "function", "is", "not", "known", ".", "The", "present", "study", "employs", "RNA", "protection", "assays", "to", "analyze", "the", "transcriptional", "status", "of", "the", "HS2", "enhancer", "in", "transfected", "recombinant", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "plasmids", ".", "In", "erythroid", "K562", "cells", "in", "which", "the", "HS2", "enhancer", "is", "active", ",", "the", "HS2", "sequence", "directs", "the", "synthesis", "of", "long", "enhancer", "transcripts", "that", "are", "initiated", "apparently", "from", "within", "the", "enhancer", "and", "elongated", "through", "the", "intervening", "DNA", "into", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "nonerythroid", "HL-60", "cells", "in", "which", "the", "HS2", "enhancer", "is", "inactive", ",", "long", "enhancer", "transcripts", "are", "not", "detectable", ".", "Splitting", "the", "HS2", "enhancer", "between", "two", "tandem", "Ap1", "sites", "abolishes", "the", "synthesis", "of", "a", "group", "of", "long", "enhancer", "transcripts", "and", "results", "in", "loss", "of", "enhancer", "function", "and", "transcriptional", "silencing", "of", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "directing", "the", "synthesis", "of", "RNA", "through", "the", "intervening", "DNA", "and", "the", "gene", "by", "a", "tracking", "and", "transcription", "mechanism", ",", "the", "HS2", "enhancer", "may", "(", "i", ")", "open", "up", "the", "chromatin", "structure", "of", "a", "gene", "domain", "and", "(", "ii", ")", "deliver", "enhancer", "binding", "proteins", "to", "the", "promoter", "sequence", "where", "they", "may", "stimulate", "the", "transcription", "of", "the", "gene", "at", "the", "cap", "site", "." ]	[ "Protein" ]
beta - like globin is a Protein, chloramphenicol acetyltransferase is a Protein, CAT is a Protein, CAT is a Protein, CAT is a Protein	245_task1	Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please typing these entity words according to sentence: beta - like globin, chloramphenicol acetyltransferase, CAT, CAT, CAT Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.	[ "Transcription", "of", "the", "hypersensitive", "site", "HS2", "enhancer", "in", "erythroid", "cells", ".", "\n", "In", "the", "human", "genome", ",", "the", "erythroid", "-", "specific", "hypersensitive", "site", "HS2", "enhancer", "regulates", "the", "transcription", "of", "the", "downstream", "beta", "-", "like", "globin", "genes", "10", "-", "50", "kilobases", "away", ".", "The", "mechanism", "of", "HS2", "enhancer", "function", "is", "not", "known", ".", "The", "present", "study", "employs", "RNA", "protection", "assays", "to", "analyze", "the", "transcriptional", "status", "of", "the", "HS2", "enhancer", "in", "transfected", "recombinant", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "plasmids", ".", "In", "erythroid", "K562", "cells", "in", "which", "the", "HS2", "enhancer", "is", "active", ",", "the", "HS2", "sequence", "directs", "the", "synthesis", "of", "long", "enhancer", "transcripts", "that", "are", "initiated", "apparently", "from", "within", "the", "enhancer", "and", "elongated", "through", "the", "intervening", "DNA", "into", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "nonerythroid", "HL-60", "cells", "in", "which", "the", "HS2", "enhancer", "is", "inactive", ",", "long", "enhancer", "transcripts", "are", "not", "detectable", ".", "Splitting", "the", "HS2", "enhancer", "between", "two", "tandem", "Ap1", "sites", "abolishes", "the", "synthesis", "of", "a", "group", "of", "long", "enhancer", "transcripts", "and", "results", "in", "loss", "of", "enhancer", "function", "and", "transcriptional", "silencing", "of", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "directing", "the", "synthesis", "of", "RNA", "through", "the", "intervening", "DNA", "and", "the", "gene", "by", "a", "tracking", "and", "transcription", "mechanism", ",", "the", "HS2", "enhancer", "may", "(", "i", ")", "open", "up", "the", "chromatin", "structure", "of", "a", "gene", "domain", "and", "(", "ii", ")", "deliver", "enhancer", "binding", "proteins", "to", "the", "promoter", "sequence", "where", "they", "may", "stimulate", "the", "transcription", "of", "the", "gene", "at", "the", "cap", "site", "." ]	[ "Protein" ]
beta - like globin, chloramphenicol acetyltransferase, CAT, CAT, CAT	245_task2	Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.	[ "Transcription", "of", "the", "hypersensitive", "site", "HS2", "enhancer", "in", "erythroid", "cells", ".", "\n", "In", "the", "human", "genome", ",", "the", "erythroid", "-", "specific", "hypersensitive", "site", "HS2", "enhancer", "regulates", "the", "transcription", "of", "the", "downstream", "beta", "-", "like", "globin", "genes", "10", "-", "50", "kilobases", "away", ".", "The", "mechanism", "of", "HS2", "enhancer", "function", "is", "not", "known", ".", "The", "present", "study", "employs", "RNA", "protection", "assays", "to", "analyze", "the", "transcriptional", "status", "of", "the", "HS2", "enhancer", "in", "transfected", "recombinant", "chloramphenicol", "acetyltransferase", "(", "CAT", ")", "plasmids", ".", "In", "erythroid", "K562", "cells", "in", "which", "the", "HS2", "enhancer", "is", "active", ",", "the", "HS2", "sequence", "directs", "the", "synthesis", "of", "long", "enhancer", "transcripts", "that", "are", "initiated", "apparently", "from", "within", "the", "enhancer", "and", "elongated", "through", "the", "intervening", "DNA", "into", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "nonerythroid", "HL-60", "cells", "in", "which", "the", "HS2", "enhancer", "is", "inactive", ",", "long", "enhancer", "transcripts", "are", "not", "detectable", ".", "Splitting", "the", "HS2", "enhancer", "between", "two", "tandem", "Ap1", "sites", "abolishes", "the", "synthesis", "of", "a", "group", "of", "long", "enhancer", "transcripts", "and", "results", "in", "loss", "of", "enhancer", "function", "and", "transcriptional", "silencing", "of", "the", "cis", "-", "linked", "CAT", "gene", ".", "In", "directing", "the", "synthesis", "of", "RNA", "through", "the", "intervening", "DNA", "and", "the", "gene", "by", "a", "tracking", "and", "transcription", "mechanism", ",", "the", "HS2", "enhancer", "may", "(", "i", ")", "open", "up", "the", "chromatin", "structure", "of", "a", "gene", "domain", "and", "(", "ii", ")", "deliver", "enhancer", "binding", "proteins", "to", "the", "promoter", "sequence", "where", "they", "may", "stimulate", "the", "transcription", "of", "the", "gene", "at", "the", "cap", "site", "." ]	[ "Protein" ]
NuA4 is a Complex, transcription adaptor is a Gene_or_gene_product, histone H4 acetyltransferase is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, ATM is a Gene_or_gene_product, Tra1p is a Gene_or_gene_product, histone H4 is a Gene_or_gene_product, chromatin is a Cellular_component, nuclear is a Cellular_component, NuA4 is a Complex, nucleosomal is a Cellular_component, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, lysines is a Simple_chemical, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, ESA1 is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, NuA4 is a Complex, esa1 is a Gene_or_gene_product, TRA1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, TRRAP is a Gene_or_gene_product, E2F is a Gene_or_gene_product, NuA4 is a Complex, chromatin is a Cellular_component, esa1 is a Gene_or_gene_product, Esa1 is a Gene_or_gene_product, HAT is a Gene_or_gene_product, NuA4 is a Complex, Tra1p is a Gene_or_gene_product, nuclear is a Cellular_component, H4 is a Gene_or_gene_product	13_task0	Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component	[ "B-Complex", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Simple_chemical", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.	[ "NuA4", ",", "an", "essential", "transcription", "adaptor", "/", "histone", "H4", "acetyltransferase", "complex", "containing", "Esa1p", "and", "the", "ATM", "-", "related", "cofactor", "Tra1p", ".", "\n", "Post", "-", "translational", "acetylation", "of", "histone", "H4", "N", "-", "terminal", "tail", "in", "chromatin", "has", "been", "associated", "with", "several", "nuclear", "processes", "including", "transcription", ".", "We", "report", "the", "purification", "and", "characterization", "of", "a", "native", "multisubunit", "complex", "(", "NuA4", ")", "from", "yeast", "that", "acetylates", "nucleosomal", "histone", "H4", ".", "NuA4", "has", "an", "apparent", "molecular", "mass", "of", "1.3", "MDa", ".", "All", "four", "conserved", "lysines", "of", "histone", "H4", "can", "be", "acetylated", "by", "NuA4", ".", "We", "have", "identified", "the", "catalytic", "subunit", "of", "the", "complex", "as", "the", "product", "of", "ESA1", ",", "an", "essential", "gene", "required", "for", "cell", "cycle", "progression", "in", "yeast", ".", "Antibodies", "against", "Esa1p", "specifically", "immunoprecipitate", "NuA4", "activity", "whereas", "the", "complex", "purified", "from", "a", "temperature", "-", "sensitive", "esa1", "mutant", "loses", "its", "acetyltransferase", "activity", "at", "the", "restrictive", "temperature", ".", "Additionally", ",", "we", "have", "identified", "another", "subunit", "of", "the", "complex", "as", "the", "product", "of", "TRA1", ",", "an", "ATM", "-", "related", "essential", "gene", "homologous", "to", "human", "TRRAP", ",", "an", "essential", "cofactor", "for", "c", "-", "Myc-", "and", "E2F", "-", "mediated", "oncogenic", "transformation", ".", "Finally", ",", "the", "ability", "of", "NuA4", "to", "stimulate", "GAL4-VP16-driven", "transcription", "from", "chromatin", "templates", "in", "vitro", "is", "also", "lost", "in", "the", "temperature", "-", "sensitive", "esa1", "mutant", ".", "The", "function", "of", "the", "essential", "Esa1", "protein", "as", "the", "HAT", "subunit", "of", "NuA4", "and", "the", "presence", "of", "Tra1p", ",", "a", "putative", "transcription", "activator", "-", "interacting", "subunit", ",", "supports", "an", "essential", "link", "between", "nuclear", "H4", "acetylation", ",", "transcriptional", "regulation", "and", "cell", "cycle", "control", ".", "\n" ]	[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical", "Complex" ]
NuA4 is a Complex, transcription adaptor is a Gene_or_gene_product, histone H4 acetyltransferase is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, ATM is a Gene_or_gene_product, Tra1p is a Gene_or_gene_product, histone H4 is a Gene_or_gene_product, chromatin is a Cellular_component, nuclear is a Cellular_component, NuA4 is a Complex, nucleosomal is a Cellular_component, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, lysines is a Simple_chemical, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, ESA1 is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, NuA4 is a Complex, esa1 is a Gene_or_gene_product, TRA1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, TRRAP is a Gene_or_gene_product, E2F is a Gene_or_gene_product, NuA4 is a Complex, chromatin is a Cellular_component, esa1 is a Gene_or_gene_product, Esa1 is a Gene_or_gene_product, HAT is a Gene_or_gene_product, NuA4 is a Complex, Tra1p is a Gene_or_gene_product, nuclear is a Cellular_component, H4 is a Gene_or_gene_product	13_task1	Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please typing these entity words according to sentence: NuA4, transcription adaptor, histone H4 acetyltransferase, Esa1p, ATM, Tra1p, histone H4, chromatin, nuclear, NuA4, nucleosomal, histone H4, NuA4, lysines, histone H4, NuA4, ESA1, Esa1p, NuA4, esa1, TRA1, ATM, TRRAP, E2F, NuA4, chromatin, esa1, Esa1, HAT, NuA4, Tra1p, nuclear, H4 Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component	[ "B-Complex", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Simple_chemical", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.	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NuA4, transcription adaptor, histone H4 acetyltransferase, Esa1p, ATM, Tra1p, histone H4, chromatin, nuclear, NuA4, nucleosomal, histone H4, NuA4, lysines, histone H4, NuA4, ESA1, Esa1p, NuA4, esa1, TRA1, ATM, TRRAP, E2F, NuA4, chromatin, esa1, Esa1, HAT, NuA4, Tra1p, nuclear, H4	13_task2	Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please extract entity words from the input sentence	[ "B-Complex", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Simple_chemical", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.	[ "NuA4", ",", "an", "essential", "transcription", "adaptor", "/", "histone", "H4", "acetyltransferase", "complex", "containing", "Esa1p", "and", "the", "ATM", "-", "related", "cofactor", "Tra1p", ".", "\n", "Post", "-", "translational", "acetylation", "of", "histone", "H4", "N", "-", "terminal", "tail", "in", "chromatin", "has", "been", "associated", "with", "several", "nuclear", "processes", "including", "transcription", ".", "We", "report", "the", "purification", "and", "characterization", "of", "a", "native", "multisubunit", "complex", "(", "NuA4", ")", "from", "yeast", "that", "acetylates", "nucleosomal", "histone", "H4", ".", "NuA4", "has", "an", "apparent", "molecular", "mass", "of", "1.3", "MDa", ".", "All", "four", "conserved", "lysines", "of", "histone", "H4", "can", "be", "acetylated", "by", "NuA4", ".", "We", "have", "identified", "the", "catalytic", "subunit", "of", "the", "complex", "as", "the", "product", "of", "ESA1", ",", "an", "essential", "gene", "required", "for", "cell", "cycle", "progression", "in", "yeast", ".", "Antibodies", "against", "Esa1p", "specifically", "immunoprecipitate", "NuA4", "activity", "whereas", "the", "complex", "purified", "from", "a", "temperature", "-", "sensitive", "esa1", "mutant", "loses", "its", "acetyltransferase", "activity", "at", "the", "restrictive", "temperature", ".", "Additionally", ",", "we", "have", "identified", "another", "subunit", "of", "the", "complex", "as", "the", "product", "of", "TRA1", ",", "an", "ATM", "-", "related", "essential", "gene", "homologous", "to", "human", "TRRAP", ",", "an", "essential", "cofactor", "for", "c", "-", "Myc-", "and", "E2F", "-", "mediated", "oncogenic", "transformation", ".", "Finally", ",", "the", "ability", "of", "NuA4", "to", "stimulate", "GAL4-VP16-driven", "transcription", "from", "chromatin", "templates", "in", "vitro", "is", "also", "lost", "in", "the", "temperature", "-", "sensitive", "esa1", "mutant", ".", "The", "function", "of", "the", "essential", "Esa1", "protein", "as", "the", "HAT", "subunit", "of", "NuA4", "and", "the", "presence", "of", "Tra1p", ",", "a", "putative", "transcription", "activator", "-", "interacting", "subunit", ",", "supports", "an", "essential", "link", "between", "nuclear", "H4", "acetylation", ",", "transcriptional", "regulation", "and", "cell", "cycle", "control", ".", "\n" ]	[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical", "Complex" ]
Objective is an umlsterm, Pemphigoid is an umlsterm, pregnancy - associated is an umlsterm, disease is an umlsterm, autoantibodies is an umlsterm, bullous pemphigoid antigen is an umlsterm, diagnostic is an umlsterm, skin is an umlsterm, biopsy is an umlsterm, autoantibodies is an umlsterm	DerHautarzt.00510025.eng.abstr_task0	Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .	[ "Background", "and", "Objective", ":", "Pemphigoid", "gestationis", "(", "PG", ")", "is", "a", "rare", "pregnancy", "-", "associated", "autoimmune", "bullous", "disease", "characterized", "by", "autoantibodies", "to", "the", "180", "kD", "bullous", "pemphigoid", "antigen", "(", "BP180", ")", ".", "The", "clinical", "spectrum", "of", "PG", "is", "polymorphic", "and", "for", "diagnostic", "purposes", ",", "a", "skin", "biopsy", "is", "usually", "taken", "demonstrating", "the", "deposition", "of", "autoantibodies", "." ]	[ "umlsterm" ]
Objective is an umlsterm, Pemphigoid is an umlsterm, pregnancy - associated is an umlsterm, disease is an umlsterm, autoantibodies is an umlsterm, bullous pemphigoid antigen is an umlsterm, diagnostic is an umlsterm, skin is an umlsterm, biopsy is an umlsterm, autoantibodies is an umlsterm	DerHautarzt.00510025.eng.abstr_task1	Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please typing these entity words according to sentence: Objective, Pemphigoid, pregnancy - associated, disease, autoantibodies, bullous pemphigoid antigen, diagnostic, skin, biopsy, autoantibodies Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .	[ "Background", "and", "Objective", ":", "Pemphigoid", "gestationis", "(", "PG", ")", "is", "a", "rare", "pregnancy", "-", "associated", "autoimmune", "bullous", "disease", "characterized", "by", "autoantibodies", "to", "the", "180", "kD", "bullous", "pemphigoid", "antigen", "(", "BP180", ")", ".", "The", "clinical", "spectrum", "of", "PG", "is", "polymorphic", "and", "for", "diagnostic", "purposes", ",", "a", "skin", "biopsy", "is", "usually", "taken", "demonstrating", "the", "deposition", "of", "autoantibodies", "." ]	[ "umlsterm" ]
Objective, Pemphigoid, pregnancy - associated, disease, autoantibodies, bullous pemphigoid antigen, diagnostic, skin, biopsy, autoantibodies	DerHautarzt.00510025.eng.abstr_task2	Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .	[ "Background", "and", "Objective", ":", "Pemphigoid", "gestationis", "(", "PG", ")", "is", "a", "rare", "pregnancy", "-", "associated", "autoimmune", "bullous", "disease", "characterized", "by", "autoantibodies", "to", "the", "180", "kD", "bullous", "pemphigoid", "antigen", "(", "BP180", ")", ".", "The", "clinical", "spectrum", "of", "PG", "is", "polymorphic", "and", "for", "diagnostic", "purposes", ",", "a", "skin", "biopsy", "is", "usually", "taken", "demonstrating", "the", "deposition", "of", "autoantibodies", "." ]	[ "umlsterm" ]
Roentgenaufnahmen is an umlsterm, Thorax is an umlsterm, Intensivtherapie is an umlsterm	DerRadiologe.80380730.ger.abstr_task0	Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .	[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]	[ "umlsterm" ]
Roentgenaufnahmen is an umlsterm, Thorax is an umlsterm, Intensivtherapie is an umlsterm	DerRadiologe.80380730.ger.abstr_task1	Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please typing these entity words according to sentence: Roentgenaufnahmen, Thorax, Intensivtherapie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .	[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]	[ "umlsterm" ]
Roentgenaufnahmen, Thorax, Intensivtherapie	DerRadiologe.80380730.ger.abstr_task2	Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .	[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]	[ "umlsterm" ]
amoxicilina - clavulánico is a NORMALIZABLES, amoxicilina - clavulánico is a NORMALIZABLES, proteína C reactiva is a PROTEINAS, PCR is a PROTEINAS, α - amilasa is a PROTEINAS, amoxicilina - clavulánico is a NORMALIZABLES	456_task0	Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.	[ "Niño", "previamente", "sano", ".", "Como", "únicos", "antecedentes", ",", "fue", "operado", "de", "criptorquidia", "izquierda", ";", "está", "vacunado", "correctamente", "para", "su", "edad", ".", "Con", "cinco", "años", "presenta", "por", "primera", "vez", "inflamación", "parotídea", "bilateral", "(", "con", "eritema", ",", "hinchazón", "y", "dolor", ")", ",", "acompañada", "de", "fiebre", "que", "fue", "manejado", "de", "forma", "ambulatoria", "con", "amoxicilina", "-", "clavulánico", "y", "antiinflamatorios", "por", "vía", "oral", ".", "Tuvo", "un", "segundo", "episodio", ",", "también", "manejado", "de", "forma", "ambulatoria", ".", "\n", "El", "tercer", "episodio", "precisó", "ingreso", "hospitalario", "por", "mala", "evolución", "clínica", "y", "afectación", "del", "estado", "general", "tras", "el", "inicio", "de", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "por", "vía", "oral", ".", "En", "la", "exploración", "física", "destacaba", "una", "tumoración", "laterocervical", "bilateral", "(", "inicialmente", "derecha", ")", "que", "borraba", "el", "ángulo", "mandibular", ",", "sin", "signos", "de", "fluctuación", "ni", "secreción", "o", "signos", "inflamatorios", "de", "conducto", "de", "Stenon", ".", "Se", "realizó", "una", "analítica", "sanguínea", ",", "que", "mostró", "una", "importante", "leucocitosis", "(", "24", "100", "/", "mm3", ")", "con", "neutrofilia", "(", "78,7", "%", ")", ",", "proteína", "C", "reactiva", "(", "PCR", ")", "de", "4,11", "mg", "/", "dl", "y", "elevación", "de", "la", "α", "-", "amilasa", "(", "hasta", "1451", "U", "/", "l", ")", ".", "Durante", "el", "ingreso", "se", "realizó", "una", "ecografía", "que", "mostró", "un", "aumento", "del", "tamaño", "de", "las", "parótidas", ",", "con", "aumento", "de", "densidad", ",", "heterogéneas", "y", "con", "focos", "hipoecoicos", ".", "El", "paciente", "recibió", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "durante", "dos", "días", "por", "vía", "intravenosa", ",", "completando", "ocho", "días", "más", "por", "vía", "oral", ",", "analgesia", "y", "antiinflamatorios", ",", "con", "buena", "evolución", "posterior", ".", "\n", "La", "consulta", "de", "Infectología", "Pediátrica", "ha", "realizado", "el", "seguimiento", "del", "paciente", ",", "desde", "donde", "se", "ha", "completado", "el", "estudio", ".", "Se", "han", "realizado", "un", "estudio", "de", "inmunidad", ",", "que", "ha", "sido", "normal", ",", "pruebas", "reumatoideas", ",", "negativas", "y", "estudio", "serológico", ",", "negativo", ",", "excepto", "la", "serología", "vacunal", "antiparotiditis", ",", "que", "fue", "positiva", ".", "\n", "En", "la", "actualidad", "no", "ha", "presentado", "nuevos", "episodios", "desde", "hace", "más", "de", "un", "año", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
amoxicilina - clavulánico is a NORMALIZABLES, amoxicilina - clavulánico is a NORMALIZABLES, proteína C reactiva is a PROTEINAS, PCR is a PROTEINAS, α - amilasa is a PROTEINAS, amoxicilina - clavulánico is a NORMALIZABLES	456_task1	Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please typing these entity words according to sentence: amoxicilina - clavulánico, amoxicilina - clavulánico, proteína C reactiva, PCR, α - amilasa, amoxicilina - clavulánico Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.	[ "Niño", "previamente", "sano", ".", "Como", "únicos", "antecedentes", ",", "fue", "operado", "de", "criptorquidia", "izquierda", ";", "está", "vacunado", "correctamente", "para", "su", "edad", ".", "Con", "cinco", "años", "presenta", "por", "primera", "vez", "inflamación", "parotídea", "bilateral", "(", "con", "eritema", ",", "hinchazón", "y", "dolor", ")", ",", "acompañada", "de", "fiebre", "que", "fue", "manejado", "de", "forma", "ambulatoria", "con", "amoxicilina", "-", "clavulánico", "y", "antiinflamatorios", "por", "vía", "oral", ".", "Tuvo", "un", "segundo", "episodio", ",", "también", "manejado", "de", "forma", "ambulatoria", ".", "\n", "El", "tercer", "episodio", "precisó", "ingreso", "hospitalario", "por", "mala", "evolución", "clínica", "y", "afectación", "del", "estado", "general", "tras", "el", "inicio", "de", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "por", "vía", "oral", ".", "En", "la", "exploración", "física", "destacaba", "una", "tumoración", "laterocervical", "bilateral", "(", "inicialmente", "derecha", ")", "que", "borraba", "el", "ángulo", "mandibular", ",", "sin", "signos", "de", "fluctuación", "ni", "secreción", "o", "signos", "inflamatorios", "de", "conducto", "de", "Stenon", ".", "Se", "realizó", "una", "analítica", "sanguínea", ",", "que", "mostró", "una", "importante", "leucocitosis", "(", "24", "100", "/", "mm3", ")", "con", "neutrofilia", "(", "78,7", "%", ")", ",", "proteína", "C", "reactiva", "(", "PCR", ")", "de", "4,11", "mg", "/", "dl", "y", "elevación", "de", "la", "α", "-", "amilasa", "(", "hasta", "1451", "U", "/", "l", ")", ".", "Durante", "el", "ingreso", "se", "realizó", "una", "ecografía", "que", "mostró", "un", "aumento", "del", "tamaño", "de", "las", "parótidas", ",", "con", "aumento", "de", "densidad", ",", "heterogéneas", "y", "con", "focos", "hipoecoicos", ".", "El", "paciente", "recibió", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "durante", "dos", "días", "por", "vía", "intravenosa", ",", "completando", "ocho", "días", "más", "por", "vía", "oral", ",", "analgesia", "y", "antiinflamatorios", ",", "con", "buena", "evolución", "posterior", ".", "\n", "La", "consulta", "de", "Infectología", "Pediátrica", "ha", "realizado", "el", "seguimiento", "del", "paciente", ",", "desde", "donde", "se", "ha", "completado", "el", "estudio", ".", "Se", "han", "realizado", "un", "estudio", "de", "inmunidad", ",", "que", "ha", "sido", "normal", ",", "pruebas", "reumatoideas", ",", "negativas", "y", "estudio", "serológico", ",", "negativo", ",", "excepto", "la", "serología", "vacunal", "antiparotiditis", ",", "que", "fue", "positiva", ".", "\n", "En", "la", "actualidad", "no", "ha", "presentado", "nuevos", "episodios", "desde", "hace", "más", "de", "un", "año", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
amoxicilina - clavulánico, amoxicilina - clavulánico, proteína C reactiva, PCR, α - amilasa, amoxicilina - clavulánico	456_task2	Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.	[ "Niño", "previamente", "sano", ".", "Como", "únicos", "antecedentes", ",", "fue", "operado", "de", "criptorquidia", "izquierda", ";", "está", "vacunado", "correctamente", "para", "su", "edad", ".", "Con", "cinco", "años", "presenta", "por", "primera", "vez", "inflamación", "parotídea", "bilateral", "(", "con", "eritema", ",", "hinchazón", "y", "dolor", ")", ",", "acompañada", "de", "fiebre", "que", "fue", "manejado", "de", "forma", "ambulatoria", "con", "amoxicilina", "-", "clavulánico", "y", "antiinflamatorios", "por", "vía", "oral", ".", "Tuvo", "un", "segundo", "episodio", ",", "también", "manejado", "de", "forma", "ambulatoria", ".", "\n", "El", "tercer", "episodio", "precisó", "ingreso", "hospitalario", "por", "mala", "evolución", "clínica", "y", "afectación", "del", "estado", "general", "tras", "el", "inicio", "de", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "por", "vía", "oral", ".", "En", "la", "exploración", "física", "destacaba", "una", "tumoración", "laterocervical", "bilateral", "(", "inicialmente", "derecha", ")", "que", "borraba", "el", "ángulo", "mandibular", ",", "sin", "signos", "de", "fluctuación", "ni", "secreción", "o", "signos", "inflamatorios", "de", "conducto", "de", "Stenon", ".", "Se", "realizó", "una", "analítica", "sanguínea", ",", "que", "mostró", "una", "importante", "leucocitosis", "(", "24", "100", "/", "mm3", ")", "con", "neutrofilia", "(", "78,7", "%", ")", ",", "proteína", "C", "reactiva", "(", "PCR", ")", "de", "4,11", "mg", "/", "dl", "y", "elevación", "de", "la", "α", "-", "amilasa", "(", "hasta", "1451", "U", "/", "l", ")", ".", "Durante", "el", "ingreso", "se", "realizó", "una", "ecografía", "que", "mostró", "un", "aumento", "del", "tamaño", "de", "las", "parótidas", ",", "con", "aumento", "de", "densidad", ",", "heterogéneas", "y", "con", "focos", "hipoecoicos", ".", "El", "paciente", "recibió", "tratamiento", "con", "amoxicilina", "-", "clavulánico", "durante", "dos", "días", "por", "vía", "intravenosa", ",", "completando", "ocho", "días", "más", "por", "vía", "oral", ",", "analgesia", "y", "antiinflamatorios", ",", "con", "buena", "evolución", "posterior", ".", "\n", "La", "consulta", "de", "Infectología", "Pediátrica", "ha", "realizado", "el", "seguimiento", "del", "paciente", ",", "desde", "donde", "se", "ha", "completado", "el", "estudio", ".", "Se", "han", "realizado", "un", "estudio", "de", "inmunidad", ",", "que", "ha", "sido", "normal", ",", "pruebas", "reumatoideas", ",", "negativas", "y", "estudio", "serológico", ",", "negativo", ",", "excepto", "la", "serología", "vacunal", "antiparotiditis", ",", "que", "fue", "positiva", ".", "\n", "En", "la", "actualidad", "no", "ha", "presentado", "nuevos", "episodios", "desde", "hace", "más", "de", "un", "año", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
human neutrophil alpha defensin 1 is a Genes & Molecular Sequences	11191_task0	Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes & Molecular Sequences	[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]	Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.	[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]	[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]
human neutrophil alpha defensin 1 is a Genes & Molecular Sequences	11191_task1	Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please typing these entity words according to sentence: human neutrophil alpha defensin 1 Options: Genes & Molecular Sequences	[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]	Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.	[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]	[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]
human neutrophil alpha defensin 1	11191_task2	Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]	Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.	[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]	[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]
cholesterol is a compound, low - density lipoprotein receptor is a protein	DS.d460_task0	Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]	Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.	[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]	[ "protein", "compound" ]
cholesterol is a compound, low - density lipoprotein receptor is a protein	DS.d460_task1	Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please typing these entity words according to sentence: cholesterol, low - density lipoprotein receptor Options: compound, protein	[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]	Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.	[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]	[ "protein", "compound" ]
cholesterol, low - density lipoprotein receptor	DS.d460_task2	Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]	Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.	[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]	[ "protein", "compound" ]
raloxifene is a Intervention_Pharmacological, bone turnover in postmenopausal women . is a Participant_Condition, accelerated bone loss following estrogen cessation . is a Participant_Condition, bone mineral density ( BMD ) is a Outcome_Physical, Women is a Participant_Sex, aged 50 to 80 years is a Participant_Age, n=20 is a Participant_Sample-size, or placebo is a Intervention_Control, n=14 is a Participant_Sample-size, no treatment . is a Intervention_Control, Bone turnover markers and bone density ( BMD ) is a Outcome_Physical, Raloxifene is a Intervention_Pharmacological, decrease in bone turnover is a Outcome_Physical, increase in spine BMD is a Outcome_Physical, hip BMD is a Outcome_Physical, bone markers is a Outcome_Physical, Hip BMD is a Outcome_Physical, Bone markers is a Outcome_Physical, Bone loss is a Outcome_Physical, accelerated bone loss . is a Participant_Condition	42563_task0	Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . 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There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .	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raloxifene is a Intervention_Pharmacological, bone turnover in postmenopausal women . is a Participant_Condition, accelerated bone loss following estrogen cessation . is a Participant_Condition, bone mineral density ( BMD ) is a Outcome_Physical, Women is a Participant_Sex, aged 50 to 80 years is a Participant_Age, n=20 is a Participant_Sample-size, or placebo is a Intervention_Control, n=14 is a Participant_Sample-size, no treatment . is a Intervention_Control, Bone turnover markers and bone density ( BMD ) is a Outcome_Physical, Raloxifene is a Intervention_Pharmacological, decrease in bone turnover is a Outcome_Physical, increase in spine BMD is a Outcome_Physical, hip BMD is a Outcome_Physical, bone markers is a Outcome_Physical, Hip BMD is a Outcome_Physical, Bone markers is a Outcome_Physical, Bone loss is a Outcome_Physical, accelerated bone loss . is a Participant_Condition	42563_task1	Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . Instructions: please typing these entity words according to sentence: raloxifene, bone turnover in postmenopausal women ., accelerated bone loss following estrogen cessation ., bone mineral density ( BMD ), Women, aged 50 to 80 years, n=20, or placebo, n=14, no treatment ., Bone turnover markers and bone density ( BMD ), Raloxifene, decrease in bone turnover, increase in spine BMD, hip BMD, bone markers, Hip BMD, Bone markers, Bone loss, accelerated bone loss . 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There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .	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raloxifene, bone turnover in postmenopausal women ., accelerated bone loss following estrogen cessation ., bone mineral density ( BMD ), Women, aged 50 to 80 years, n=20, or placebo, n=14, no treatment ., Bone turnover markers and bone density ( BMD ), Raloxifene, decrease in bone turnover, increase in spine BMD, hip BMD, bone markers, Hip BMD, Bone markers, Bone loss, accelerated bone loss .	42563_task2	Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Participant_Sex", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .	[ "The", "effect", "of", "cessation", "of", "raloxifene", "treatment", "on", "bone", "turnover", "in", "postmenopausal", "women", ".", "There", "is", "evidence", "to", "suggest", "accelerated", "bone", "loss", "following", "estrogen", "cessation", ".", "The", "effect", "of", "cessation", "of", "raloxifene", "therapy", "on", "bone", "turnover", "is", "unknown", ".", "Our", "aim", "was", "to", "determine", "the", "effect", "of", "cessation", "of", "raloxifene", "treatment", "on", "bone", "turnover", "and", "bone", "mineral", "density", "(", "BMD", ")", "in", "postmenopausal", ",", "osteopenic", "women", ".", "Women", "aged", "50", "to", "80", "years", "received", "raloxifene", "for", "96", "weeks", "and", "were", "then", "randomized", "to", "continue", "raloxifene", "(", "group", "1", ",", "n=20", ")", "or", "placebo", "(", "group", "2", ",", "n=20", ")", "for", "a", "further", "96", "weeks", ".", "A", "third", "group", "(", "group", "3", ",", "n=14", ")", "received", "no", "treatment", ".", "Bone", "turnover", "markers", "and", "bone", "density", "(", "BMD", ")", "were", "measured", "throughout", "the", "study", ".", "Raloxifene", "treatment", "for", "96", "weeks", "resulted", "in", "a", "decrease", "in", "bone", "turnover", "(", "PINP", "by", "31", "%", ")", "and", "an", "increase", "in", "spine", "BMD", "(", "by", "2", "%", ")", "but", "no", "change", "in", "hip", "BMD", "for", "groups", "1", "and", "2", ".", "Continuation", "of", "raloxifene", "(", "group", "1", ")", "maintained", "these", "changes", ".", "Following", "cessation", "of", "raloxifene", "(", "group", "2", ")", ",", "bone", "markers", "returned", "to", "baseline", "levels", "(", "by", "120", "weeks", ")", ".", "Hip", "BMD", "was", "decreased", "by", "2", "%", "at", "192", "weeks", "compared", "to", "baseline", ".", "Bone", "markers", "in", "the", "controls", "(", "group", "3", ")", "remained", "at", "the", "upper", "limit", "of", "the", "reference", "range", "throughout", ",", "with", "decreases", "in", "BMD", "of", "2.3", "%", "(", "spine", ")", "and", "2.8", "%", "(", "hip", ")", ".", "Bone", "loss", "following", "cessation", "of", "raloxifene", "therapy", "at", "96", "weeks", "was", "greater", "than", "in", "the", "control", "group", ",", "suggesting", "accelerated", "bone", "loss", ".", "The", "beneficial", "effect", "on", "bone", "turnover", "of", "96", "weeks", "of", "raloxifene", "was", "lost", "6", "months", "after", "cessation", "of", "treatment", "." ]	[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Control", "Intervention_Pharmacological", "Participant_Sex", "Participant_Sample-size" ]
Hepatocellular carcinoma is an umlsterm, frequency is an umlsterm, Western world is an umlsterm, hepatitis C is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, Liver transplantation is an umlsterm, liver is an umlsterm, selection criteria is an umlsterm, patient is an umlsterm, evaluation is an umlsterm, complications is an umlsterm, cryotherapy is an umlsterm, Liver transplantation is an umlsterm, treatment is an umlsterm, line is an umlsterm, treatment is an umlsterm, patients is an umlsterm	DerChirurg.80690360.eng.abstr_task0	Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .	[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]	[ "umlsterm" ]
Hepatocellular carcinoma is an umlsterm, frequency is an umlsterm, Western world is an umlsterm, hepatitis C is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, Liver transplantation is an umlsterm, liver is an umlsterm, selection criteria is an umlsterm, patient is an umlsterm, evaluation is an umlsterm, complications is an umlsterm, cryotherapy is an umlsterm, Liver transplantation is an umlsterm, treatment is an umlsterm, line is an umlsterm, treatment is an umlsterm, patients is an umlsterm	DerChirurg.80690360.eng.abstr_task1	Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please typing these entity words according to sentence: Hepatocellular carcinoma, frequency, Western world, hepatitis C, therapy, treatment, tumor, control, Liver transplantation, liver, selection criteria, patient, evaluation, complications, cryotherapy, Liver transplantation, treatment, line, treatment, patients Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .	[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]	[ "umlsterm" ]
Hepatocellular carcinoma, frequency, Western world, hepatitis C, therapy, treatment, tumor, control, Liver transplantation, liver, selection criteria, patient, evaluation, complications, cryotherapy, Liver transplantation, treatment, line, treatment, patients	DerChirurg.80690360.eng.abstr_task2	Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .	[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]	[ "umlsterm" ]
Glucose is a compound, insulin is a protein	DS.d784_task0	Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.	[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]	[ "compound", "protein" ]
Glucose is a compound, insulin is a protein	DS.d784_task1	Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please typing these entity words according to sentence: Glucose, insulin Options: compound, protein	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.	[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]	[ "compound", "protein" ]
Glucose, insulin	DS.d784_task2	Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please extract entity words from the input sentence	[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.	[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]	[ "compound", "protein" ]
plate is an umlsterm, anatomical is an umlsterm, joint is an umlsterm, fractures is an umlsterm, bone is an umlsterm, bone is an umlsterm, anatomical is an umlsterm, plate is an umlsterm, bone necrosis is an umlsterm, fracture is an umlsterm, callus is an umlsterm, Direct is an umlsterm, method is an umlsterm, bone is an umlsterm, necrosis is an umlsterm, bones is an umlsterm, plate is an umlsterm, method is an umlsterm, technique is an umlsterm, fractures is an umlsterm, Elasticity is an umlsterm, screws is an umlsterm, fracture is an umlsterm, titanium is an umlsterm, plate is an umlsterm, plate is an umlsterm, fitting is an umlsterm, screws is an umlsterm, devices is an umlsterm, intention is an umlsterm, fracture 's is an umlsterm, muscle is an umlsterm, fracture is an umlsterm, callus is an umlsterm, tissue is an umlsterm, bone is an umlsterm, accident is an umlsterm, University is an umlsterm, trauma is an umlsterm, fractures is an umlsterm, technique is an umlsterm, bone is an umlsterm, pseudoarthrosis is an umlsterm, bone infection is an umlsterm, risks of is an umlsterm, plate is an umlsterm, methods is an umlsterm, screws is an umlsterm	DerUnfallchirurg.60990816.eng.abstr_task0	Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .	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plate is an umlsterm, anatomical is an umlsterm, joint is an umlsterm, fractures is an umlsterm, bone is an umlsterm, bone is an umlsterm, anatomical is an umlsterm, plate is an umlsterm, bone necrosis is an umlsterm, fracture is an umlsterm, callus is an umlsterm, Direct is an umlsterm, method is an umlsterm, bone is an umlsterm, necrosis is an umlsterm, bones is an umlsterm, plate is an umlsterm, method is an umlsterm, technique is an umlsterm, fractures is an umlsterm, Elasticity is an umlsterm, screws is an umlsterm, fracture is an umlsterm, titanium is an umlsterm, plate is an umlsterm, plate is an umlsterm, fitting is an umlsterm, screws is an umlsterm, devices is an umlsterm, intention is an umlsterm, fracture 's is an umlsterm, muscle is an umlsterm, fracture is an umlsterm, callus is an umlsterm, tissue is an umlsterm, bone is an umlsterm, accident is an umlsterm, University is an umlsterm, trauma is an umlsterm, fractures is an umlsterm, technique is an umlsterm, bone is an umlsterm, pseudoarthrosis is an umlsterm, bone infection is an umlsterm, risks of is an umlsterm, plate is an umlsterm, methods is an umlsterm, screws is an umlsterm	DerUnfallchirurg.60990816.eng.abstr_task1	Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please typing these entity words according to sentence: plate, anatomical, joint, fractures, bone, bone, anatomical, plate, bone necrosis, fracture, callus, Direct, method, bone, necrosis, bones, plate, method, technique, fractures, Elasticity, screws, fracture, titanium, plate, plate, fitting, screws, devices, intention, fracture 's, muscle, fracture, callus, tissue, bone, accident, University, trauma, fractures, technique, bone, pseudoarthrosis, bone infection, risks of, plate, methods, screws Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .	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plate, anatomical, joint, fractures, bone, bone, anatomical, plate, bone necrosis, fracture, callus, Direct, method, bone, necrosis, bones, plate, method, technique, fractures, Elasticity, screws, fracture, titanium, plate, plate, fitting, screws, devices, intention, fracture 's, muscle, fracture, callus, tissue, bone, accident, University, trauma, fractures, technique, bone, pseudoarthrosis, bone infection, risks of, plate, methods, screws	DerUnfallchirurg.60990816.eng.abstr_task2	Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .	[ "Classical", "stable", "plate", "osteosynthesis", "with", "its", "anatomical", "repositioning", ",", "absolute", "stability", "between", "fragments", "and", "medial", "support", "should", "only", "be", "applied", "to", "joint", "fractures", "and", "spongy", "bone", ".", "In", "cortical", "bone", ",", "the", "anatomical", "reposition", "connected", "with", "the", "plate", "promotes", "bone", "necrosis", "along", "the", "fracture", "and", "prevents", "callus", "formation", ".", "Direct", "cortical", "synthesis", ",", "a", "method", "also", "known", "as", "\"", "primary", "bone", "healing", "\"", ",", "serves", "the", "bone", "'s", "revascularisation", "and", "is", "not", "necessarily", "aimed", "at", "healing", ".", "Thus", ",", "this", "may", "also", "be", "termed", "\"", "necrosis", "healing", "\"", ".", "Along", "the", "shaft", "of", "long", "bones", ",", "elastic", "plate", "osteosynthesis", ",", "a", "biological", "method", ",", "is", "safer", "than", "and", "superior", "to", "the", "rigid", "technique", ".", "This", "even", "applies", "to", "short", "oblique", "and", "transverse", "fractures", "insofar", "as", "nailing", "does", "not", "appear", "feasible", ".", "Elasticity", "is", "achieved", "by", "leaving", "a", "flexible", "stretch", "of", "at", "least", "2", "-", "4", "holes", ",", "i.e", ".", "as", "long", "as", "possible", ",", "without", "screws", "over", "the", "fracture", "and", "by", "employing", "a", "titanium", "plate", ".", "Thus", ",", "there", "is", "no", "punctate", "fatigue", "leading", "to", "plate", "breakage", ".", "The", "fitting", "of", "third", "fragments", "is", "deliberately", "left", "out", ".", "The", "same", "applies", "to", "all", "kinds", "of", "compression", "with", "lag", "screws", ",", "tension", "devices", "or", "DC", "-", "gliding", "holes", "-", "and", "this", "with", "the", "intention", "of", "allowing", "micromovements", "in", "the", "fracture", "'s", "fissure", ".", "Periost", "and", "muscle", "are", "not", "removed", "and", "the", "fracture", "is", "not", "examined", ".", "Healing", "occurs", "spontaneously", "via", "a", "fixating", "callus", "forming", "within", "the", "first", "3", "-", "6", "weeks", "out", "of", "the", "periost", "-", "soft", "tissue", "combination", ".", "Histomorphological", "investigation", "dates", "the", "first", "woven-", "bone", "bridges", "between", "the", "fragments", "to", "3", "weeks", "subsequent", "to", "the", "accident", ".", "In", "Goettingen", "University", "trauma", "centre", ",", "87", "fractures", "have", "been", "attended", "to", "over", "2", "years", "using", "this", "technique", ".", "Despite", "considerable", "soft", "-", "tissue", "damage", ",", "no", "delayed", "bone", "healing", ",", "pseudoarthrosis", "or", "bone", "infection", "has", "been", "observed", ".", "The", "risks", "of", "elastic", "plate", "osteosynthesis", "lie", "in", "unbiological", "and", "exaggerated", "reposition", "methods", ",", "too", "short", "a", "flexible", "stretch", ",", "and", "insufficient", "anchorage", "of", "the", "screws", "." ]	[ "umlsterm" ]
E - cadherin is a Gene/protein/RNA, alpha - catenin is a Gene/protein/RNA, beta - catenin is a Gene/protein/RNA	514_task0	Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.	[ "Loss", "of", "memberanous", "expression", "of", "E", "-", "cadherin", ",", "alpha", "-", "catenin", "and", "beta", "-", "catenin", "was", "demonstrated", "in", "52", "%", ",", "85", "%", "and", "40", "%", "of", "tumours", "respectively", "." ]	[ "Gene/protein/RNA" ]
E - cadherin is a Gene/protein/RNA, alpha - catenin is a Gene/protein/RNA, beta - catenin is a Gene/protein/RNA	514_task1	Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please typing these entity words according to sentence: E - cadherin, alpha - catenin, beta - catenin Options: Gene/protein/RNA	[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.	[ "Loss", "of", "memberanous", "expression", "of", "E", "-", "cadherin", ",", "alpha", "-", "catenin", "and", "beta", "-", "catenin", "was", "demonstrated", "in", "52", "%", ",", "85", "%", "and", "40", "%", "of", "tumours", "respectively", "." ]	[ "Gene/protein/RNA" ]
E - cadherin, alpha - catenin, beta - catenin	514_task2	Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.	[ "Loss", "of", "memberanous", "expression", "of", "E", "-", "cadherin", ",", "alpha", "-", "catenin", "and", "beta", "-", "catenin", "was", "demonstrated", "in", "52", "%", ",", "85", "%", "and", "40", "%", "of", "tumours", "respectively", "." ]	[ "Gene/protein/RNA" ]
Pathogenic aspects is an umlsterm, interstitial cystitis is an umlsterm, literature is an umlsterm, criteria is an umlsterm, evidence - based medicine is an umlsterm, publications is an umlsterm, MEDLINE is an umlsterm, interstitial cystitis is an umlsterm, pathogenesis is an umlsterm, etiology is an umlsterm, criteria is an umlsterm, papers is an umlsterm	DerUrologeA.00390520.eng.abstr_task0	Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .	[ "Pathogenic", "aspects", "of", "interstitial", "cystitis", "(", "IC", ")", "are", "reviewed", "on", "the", "basis", "of", "the", "current", "literature", "applying", "the", "criteria", "of", "evidence", "-", "based", "medicine", "(", "EBM", ")", ".", "Three", "hundred", "forty", "-", "six", "peer", "-", "reviewed", "publications", "of", "the", "past", "30", "years", "were", "retrieved", "via", "MEDLINE", "employing", "the", "key", "words", "\"", "interstitial", "cystitis", "and", "pathogenesis", "or", "etiology", "\"", "and", "classified", "according", "to", "EBM", "criteria", "and", "subject", "categories", ".", "The", "papers", "were", "then", "reviewed", "and", "summarized", "and", "are", "discussed", "considering", "the", "theory", "of", "acute", "and", "chronic", "inflammatory", "responses", "." ]	[ "umlsterm" ]
Pathogenic aspects is an umlsterm, interstitial cystitis is an umlsterm, literature is an umlsterm, criteria is an umlsterm, evidence - based medicine is an umlsterm, publications is an umlsterm, MEDLINE is an umlsterm, interstitial cystitis is an umlsterm, pathogenesis is an umlsterm, etiology is an umlsterm, criteria is an umlsterm, papers is an umlsterm	DerUrologeA.00390520.eng.abstr_task1	Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please typing these entity words according to sentence: Pathogenic aspects, interstitial cystitis, literature, criteria, evidence - based medicine, publications, MEDLINE, interstitial cystitis, pathogenesis, etiology, criteria, papers Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .	[ "Pathogenic", "aspects", "of", "interstitial", "cystitis", "(", "IC", ")", "are", "reviewed", "on", "the", "basis", "of", "the", "current", "literature", "applying", "the", "criteria", "of", "evidence", "-", "based", "medicine", "(", "EBM", ")", ".", "Three", "hundred", "forty", "-", "six", "peer", "-", "reviewed", "publications", "of", "the", "past", "30", "years", "were", "retrieved", "via", "MEDLINE", "employing", "the", "key", "words", "\"", "interstitial", "cystitis", "and", "pathogenesis", "or", "etiology", "\"", "and", "classified", "according", "to", "EBM", "criteria", "and", "subject", "categories", ".", "The", "papers", "were", "then", "reviewed", "and", "summarized", "and", "are", "discussed", "considering", "the", "theory", "of", "acute", "and", "chronic", "inflammatory", "responses", "." ]	[ "umlsterm" ]
Pathogenic aspects, interstitial cystitis, literature, criteria, evidence - based medicine, publications, MEDLINE, interstitial cystitis, pathogenesis, etiology, criteria, papers	DerUrologeA.00390520.eng.abstr_task2	Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .	[ "Pathogenic", "aspects", "of", "interstitial", "cystitis", "(", "IC", ")", "are", "reviewed", "on", "the", "basis", "of", "the", "current", "literature", "applying", "the", "criteria", "of", "evidence", "-", "based", "medicine", "(", "EBM", ")", ".", "Three", "hundred", "forty", "-", "six", "peer", "-", "reviewed", "publications", "of", "the", "past", "30", "years", "were", "retrieved", "via", "MEDLINE", "employing", "the", "key", "words", "\"", "interstitial", "cystitis", "and", "pathogenesis", "or", "etiology", "\"", "and", "classified", "according", "to", "EBM", "criteria", "and", "subject", "categories", ".", "The", "papers", "were", "then", "reviewed", "and", "summarized", "and", "are", "discussed", "considering", "the", "theory", "of", "acute", "and", "chronic", "inflammatory", "responses", "." ]	[ "umlsterm" ]
Schilddruese is an umlsterm, Infektionen is an umlsterm, Bakterien is an umlsterm, Pilze is an umlsterm, Parasiten is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, Infektion is an umlsterm, Sepsis is an umlsterm, Infektionsdiagnostik is an umlsterm, Differentialdiagnose is an umlsterm, alkohol - toxischen is an umlsterm, Pankreatitis is an umlsterm, Transplantationsmedizin is an umlsterm, Komplikationen is an umlsterm	IntensiveMedizin.70340381.ger.abstr_task0	Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .	[ "Procalcitonin", "ist", "das", "hormonell", "inaktive", "Propeptid", "des", "Calcitonins", ".", "Bei", "Gesunden", "wird", "Procalcitonin", "in", "den", "C", "-", "Zellen", "der", "Schilddruese", "produziert", "und", "proteolytisch", "gespalten", ",", "so", "dass", "der", "Serumspiegel", "unter", "0,1", "ng", "/", "ml", "liegt", ".", "Bei", "schweren", "generalisierten", "Infektionen", "(", "durch", "Bakterien", ",", "Pilze", "oder", "Parasiten", ")", "mit", "systemischer", "Manifestation", "werden", "PCT", "-", "Serumspiegel", "bis", "zu", "100", "ng", "/", "ml", "erreicht", ".", "Schwere", "virale", "Infektionen", "und", "nicht", "-", "infektionsbedingte", "inflammatorische", "Reaktionen", "hingegen", "fuehren", "zu", "keiner", "oder", "nur", "geringer", "PCT", "-", "Erhoehung", ".", "Der", "Syntheseort", "dieses", "Procalcitonins", "ist", "noch", "unbekannt", ",", "sicher", "ist", "aber", ",", "dass", "auch", "sehr", "ausgepraegte", "Erhoehungen", "des", "Serumprocalcitoninspiegels", "nicht", "zu", "einem", "Ansteigen", "des", "Serumcalcitoninspiegels", "oder", "erhoehter", "Calcitoninaktivitaet", "fuehren", ".", "Procalcitoninverlaufskontrollen", "scheinen", "bei", "Patienten", "nuetzlich", ",", "die", "gefaehrdet", "sind", ",", "eine", "systemische", "Infektion", "bzw", ".", "Sepsis", "zu", "entwickeln", ".", "Ansteigende", "oder", "permanent", "erhoehte", "PCT", "-", "Werte", "stellen", "die", "Indikation", "fuer", "eine", "weitere", "Infektionsdiagnostik", "(", "Focussuche", ")", "dar", ".", "Die", "Procalcitoninbestimmung", "kann", "zur", "Unterscheidung", "zwischen", "infektioesen", "und", "nichtinfektioesen", "Ursachen", "bei", "der", "Differentialdiagnose", "von", "Erkrankungen", ",", "die", "mit", "den", "Zeichen", "der", "systemischen", "Inflammation", "einhergehen", ",", "hilfreich", "sein", ".", "Dies", "gilt", "auch", "fuer", "die", "Unterscheidung", "zwischen", "der", "infektioes", "-", "cholestatischen", "versus", "alkohol", "-", "toxischen", "Pankreatitis", ",", "des", "infektioesen", "versus", "nichtinfektioesen", "ARDS", "sowie", "in", "der", "Transplantationsmedizin", "zur", "Unterscheidung", "zwischen", "Abstossungsreaktionen", "und", "schweren", "infektioesen", "Komplikationen", "." ]	[ "umlsterm" ]
Schilddruese is an umlsterm, Infektionen is an umlsterm, Bakterien is an umlsterm, Pilze is an umlsterm, Parasiten is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, Infektion is an umlsterm, Sepsis is an umlsterm, Infektionsdiagnostik is an umlsterm, Differentialdiagnose is an umlsterm, alkohol - toxischen is an umlsterm, Pankreatitis is an umlsterm, Transplantationsmedizin is an umlsterm, Komplikationen is an umlsterm	IntensiveMedizin.70340381.ger.abstr_task1	Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please typing these entity words according to sentence: Schilddruese, Infektionen, Bakterien, Pilze, Parasiten, Infektionen, Patienten, Infektion, Sepsis, Infektionsdiagnostik, Differentialdiagnose, alkohol - toxischen, Pankreatitis, Transplantationsmedizin, Komplikationen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .	[ "Procalcitonin", "ist", "das", "hormonell", "inaktive", "Propeptid", "des", "Calcitonins", ".", "Bei", "Gesunden", "wird", "Procalcitonin", "in", "den", "C", "-", "Zellen", "der", "Schilddruese", "produziert", "und", "proteolytisch", "gespalten", ",", "so", "dass", "der", "Serumspiegel", "unter", "0,1", "ng", "/", "ml", "liegt", ".", "Bei", "schweren", "generalisierten", "Infektionen", "(", "durch", "Bakterien", ",", "Pilze", "oder", "Parasiten", ")", "mit", "systemischer", "Manifestation", "werden", "PCT", "-", "Serumspiegel", "bis", "zu", "100", "ng", "/", "ml", "erreicht", ".", "Schwere", "virale", "Infektionen", "und", "nicht", "-", "infektionsbedingte", "inflammatorische", "Reaktionen", "hingegen", "fuehren", "zu", "keiner", "oder", "nur", "geringer", "PCT", "-", "Erhoehung", ".", "Der", "Syntheseort", "dieses", "Procalcitonins", "ist", "noch", "unbekannt", ",", "sicher", "ist", "aber", ",", "dass", "auch", "sehr", "ausgepraegte", "Erhoehungen", "des", "Serumprocalcitoninspiegels", "nicht", "zu", "einem", "Ansteigen", "des", "Serumcalcitoninspiegels", "oder", "erhoehter", "Calcitoninaktivitaet", "fuehren", ".", "Procalcitoninverlaufskontrollen", "scheinen", "bei", "Patienten", "nuetzlich", ",", "die", "gefaehrdet", "sind", ",", "eine", "systemische", "Infektion", "bzw", ".", "Sepsis", "zu", "entwickeln", ".", "Ansteigende", "oder", "permanent", "erhoehte", "PCT", "-", "Werte", "stellen", "die", "Indikation", "fuer", "eine", "weitere", "Infektionsdiagnostik", "(", "Focussuche", ")", "dar", ".", "Die", "Procalcitoninbestimmung", "kann", "zur", "Unterscheidung", "zwischen", "infektioesen", "und", "nichtinfektioesen", "Ursachen", "bei", "der", "Differentialdiagnose", "von", "Erkrankungen", ",", "die", "mit", "den", "Zeichen", "der", "systemischen", "Inflammation", "einhergehen", ",", "hilfreich", "sein", ".", "Dies", "gilt", "auch", "fuer", "die", "Unterscheidung", "zwischen", "der", "infektioes", "-", "cholestatischen", "versus", "alkohol", "-", "toxischen", "Pankreatitis", ",", "des", "infektioesen", "versus", "nichtinfektioesen", "ARDS", "sowie", "in", "der", "Transplantationsmedizin", "zur", "Unterscheidung", "zwischen", "Abstossungsreaktionen", "und", "schweren", "infektioesen", "Komplikationen", "." ]	[ "umlsterm" ]
Schilddruese, Infektionen, Bakterien, Pilze, Parasiten, Infektionen, Patienten, Infektion, Sepsis, Infektionsdiagnostik, Differentialdiagnose, alkohol - toxischen, Pankreatitis, Transplantationsmedizin, Komplikationen	IntensiveMedizin.70340381.ger.abstr_task2	Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .	[ "Procalcitonin", "ist", "das", "hormonell", "inaktive", "Propeptid", "des", "Calcitonins", ".", "Bei", "Gesunden", "wird", "Procalcitonin", "in", "den", "C", "-", "Zellen", "der", "Schilddruese", "produziert", "und", "proteolytisch", "gespalten", ",", "so", "dass", "der", "Serumspiegel", "unter", "0,1", "ng", "/", "ml", "liegt", ".", "Bei", "schweren", "generalisierten", "Infektionen", "(", "durch", "Bakterien", ",", "Pilze", "oder", "Parasiten", ")", "mit", "systemischer", "Manifestation", "werden", "PCT", "-", "Serumspiegel", "bis", "zu", "100", "ng", "/", "ml", "erreicht", ".", "Schwere", "virale", "Infektionen", "und", "nicht", "-", "infektionsbedingte", "inflammatorische", "Reaktionen", "hingegen", "fuehren", "zu", "keiner", "oder", "nur", "geringer", "PCT", "-", "Erhoehung", ".", "Der", "Syntheseort", "dieses", "Procalcitonins", "ist", "noch", "unbekannt", ",", "sicher", "ist", "aber", ",", "dass", "auch", "sehr", "ausgepraegte", "Erhoehungen", "des", "Serumprocalcitoninspiegels", "nicht", "zu", "einem", "Ansteigen", "des", "Serumcalcitoninspiegels", "oder", "erhoehter", "Calcitoninaktivitaet", "fuehren", ".", "Procalcitoninverlaufskontrollen", "scheinen", "bei", "Patienten", "nuetzlich", ",", "die", "gefaehrdet", "sind", ",", "eine", "systemische", "Infektion", "bzw", ".", "Sepsis", "zu", "entwickeln", ".", "Ansteigende", "oder", "permanent", "erhoehte", "PCT", "-", "Werte", "stellen", "die", "Indikation", "fuer", "eine", "weitere", "Infektionsdiagnostik", "(", "Focussuche", ")", "dar", ".", "Die", "Procalcitoninbestimmung", "kann", "zur", "Unterscheidung", "zwischen", "infektioesen", "und", "nichtinfektioesen", "Ursachen", "bei", "der", "Differentialdiagnose", "von", "Erkrankungen", ",", "die", "mit", "den", "Zeichen", "der", "systemischen", "Inflammation", "einhergehen", ",", "hilfreich", "sein", ".", "Dies", "gilt", "auch", "fuer", "die", "Unterscheidung", "zwischen", "der", "infektioes", "-", "cholestatischen", "versus", "alkohol", "-", "toxischen", "Pankreatitis", ",", "des", "infektioesen", "versus", "nichtinfektioesen", "ARDS", "sowie", "in", "der", "Transplantationsmedizin", "zur", "Unterscheidung", "zwischen", "Abstossungsreaktionen", "und", "schweren", "infektioesen", "Komplikationen", "." ]	[ "umlsterm" ]
cysteine tRNA synthetase is a Protein, cysteine tRNA synthetase is a Protein	579_task0	Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.	[ "A", "strategy", "of", "tRNA", "recognition", "that", "includes", "determinants", "of", "RNA", "structure", ".", "\n", "Recognition", "of", "tRNAs", "by", "aminoacyl", "tRNA", "synthetases", "establishes", "the", "connection", "between", "amino", "acids", "and", "anticodon", "triplets", "of", "the", "genetic", "code", ".", "Although", "anticodons", "and", "nucleotides", "adjacent", "to", "the", "amino", "acid", "attachment", "site", "are", "generally", "important", ",", "the", "tertiary", "structural", "framework", "of", "tRNAs", "has", "recently", "been", "implicated", "to", "have", "a", "role", "in", "tRNA", "recognition", ".", "A", "G15", ":", "G48", "tertiary", "hydrogen", "base", "pair", "of", "E.", "coli", "tRNA(Cys", ")", "is", "important", "for", "recognition", "of", "the", "tRNA", "by", "cysteine", "tRNA", "synthetase", ".", "This", "base", "pair", "is", "proposed", "to", "consist", "of", "N2", ":", "N3", ",", "rather", "than", "N1", ":", "O6", ",", "hydrogen", "bonds", ".", "The", "reproduction", "of", "the", "hydrogen", "pairing", "scheme", "of", "tRNA(Gly", ")", ".", "This", "reproduction", "required", "an", "A13", ":", "A22", "mismatch", "in", "the", "dihyrouridine", "stem", ".", "To", "determine", "if", "A13", ":", "A22", "is", "a", "determinant", "of", "the", "structural", "features", "of", "G15", ":", "G48", ",", "we", "investigated", "the", "A15", ":", "U48", "and", "A15", ":", "A48", "variants", "of", "tRNA(Gly", ")", "which", "harbored", "specific", "substitutions", "of", "A13", ":", "A22", ".", "We", "show", "here", "that", "introduction", "of", "A13", ":", "A22", "to", "both", "tRNA", "frameworks", "confers", "structural", "features", "similar", "to", "those", "of", "G15", ":", "G48", "in", "E.", "coli", "tRNA(Cys", ")", ".", "These", "structural", "features", "are", "accompanied", "by", "efficient", "recognition", "of", "both", "tRNAs", "by", "cysteine", "tRNA", "synthetase", ".", "Substitution", "of", "A13", ":", "A22", "with", "U13", ":", "A22", "alters", "the", "structural", "features", "at", "15:48", "and", "impairs", "tRNA", "recognition", ".", "The", "dependence", "on", "A13:22", "for", "tRNA", "recognition", "has", "a", "distinct", "similarity", "to", "that", "of", "E.", "coli", "tRNA(Cys", ")", "and", "to", "that", "of", "the", "G15", ":", "G48", "variant", "of", "tRNA(Gly", ")", ".", "The", "results", "have", "implications", "for", "the", "design", "and", "manipulation", "of", "RNA", "structural", "elements", "as", "the", "basis", "for", "tRNA", "recognition", ".", "\n" ]	[ "Protein" ]
cysteine tRNA synthetase is a Protein, cysteine tRNA synthetase is a Protein	579_task1	Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please typing these entity words according to sentence: cysteine tRNA synthetase, cysteine tRNA synthetase Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.	[ "A", "strategy", "of", "tRNA", "recognition", "that", "includes", "determinants", "of", "RNA", "structure", ".", "\n", "Recognition", "of", "tRNAs", "by", "aminoacyl", "tRNA", "synthetases", "establishes", "the", "connection", "between", "amino", "acids", "and", "anticodon", "triplets", "of", "the", "genetic", "code", ".", "Although", "anticodons", "and", "nucleotides", "adjacent", "to", "the", "amino", "acid", "attachment", "site", "are", "generally", "important", ",", "the", "tertiary", "structural", "framework", "of", "tRNAs", "has", "recently", "been", "implicated", "to", "have", "a", "role", "in", "tRNA", "recognition", ".", "A", "G15", ":", "G48", "tertiary", "hydrogen", "base", "pair", "of", "E.", "coli", "tRNA(Cys", ")", "is", "important", "for", "recognition", "of", "the", "tRNA", "by", "cysteine", "tRNA", "synthetase", ".", "This", "base", "pair", "is", "proposed", "to", "consist", "of", "N2", ":", "N3", ",", "rather", "than", "N1", ":", "O6", ",", "hydrogen", "bonds", ".", "The", "reproduction", "of", "the", "hydrogen", "pairing", "scheme", "of", "tRNA(Gly", ")", ".", "This", "reproduction", "required", "an", "A13", ":", "A22", "mismatch", "in", "the", "dihyrouridine", "stem", ".", "To", "determine", "if", "A13", ":", "A22", "is", "a", "determinant", "of", "the", "structural", "features", "of", "G15", ":", "G48", ",", "we", "investigated", "the", "A15", ":", "U48", "and", "A15", ":", "A48", "variants", "of", "tRNA(Gly", ")", "which", "harbored", "specific", "substitutions", "of", "A13", ":", "A22", ".", "We", "show", "here", "that", "introduction", "of", "A13", ":", "A22", "to", "both", "tRNA", "frameworks", "confers", "structural", "features", "similar", "to", "those", "of", "G15", ":", "G48", "in", "E.", "coli", "tRNA(Cys", ")", ".", "These", "structural", "features", "are", "accompanied", "by", "efficient", "recognition", "of", "both", "tRNAs", "by", "cysteine", "tRNA", "synthetase", ".", "Substitution", "of", "A13", ":", "A22", "with", "U13", ":", "A22", "alters", "the", "structural", "features", "at", "15:48", "and", "impairs", "tRNA", "recognition", ".", "The", "dependence", "on", "A13:22", "for", "tRNA", "recognition", "has", "a", "distinct", "similarity", "to", "that", "of", "E.", "coli", "tRNA(Cys", ")", "and", "to", "that", "of", "the", "G15", ":", "G48", "variant", "of", "tRNA(Gly", ")", ".", "The", "results", "have", "implications", "for", "the", "design", "and", "manipulation", "of", "RNA", "structural", "elements", "as", "the", "basis", "for", "tRNA", "recognition", ".", "\n" ]	[ "Protein" ]
cysteine tRNA synthetase, cysteine tRNA synthetase	579_task2	Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.	[ "A", "strategy", "of", "tRNA", "recognition", "that", "includes", "determinants", "of", "RNA", "structure", ".", "\n", "Recognition", "of", "tRNAs", "by", "aminoacyl", "tRNA", "synthetases", "establishes", "the", "connection", "between", "amino", "acids", "and", "anticodon", "triplets", "of", "the", "genetic", "code", ".", "Although", "anticodons", "and", "nucleotides", "adjacent", "to", "the", "amino", "acid", "attachment", "site", "are", "generally", "important", ",", "the", "tertiary", "structural", "framework", "of", "tRNAs", "has", "recently", "been", "implicated", "to", "have", "a", "role", "in", "tRNA", "recognition", ".", "A", "G15", ":", "G48", "tertiary", "hydrogen", "base", "pair", "of", "E.", "coli", "tRNA(Cys", ")", "is", "important", "for", "recognition", "of", "the", "tRNA", "by", "cysteine", "tRNA", "synthetase", ".", "This", "base", "pair", "is", "proposed", "to", "consist", "of", "N2", ":", "N3", ",", "rather", "than", "N1", ":", "O6", ",", "hydrogen", "bonds", ".", "The", "reproduction", "of", "the", "hydrogen", "pairing", "scheme", "of", "tRNA(Gly", ")", ".", "This", "reproduction", "required", "an", "A13", ":", "A22", "mismatch", "in", "the", "dihyrouridine", "stem", ".", "To", "determine", "if", "A13", ":", "A22", "is", "a", "determinant", "of", "the", "structural", "features", "of", "G15", ":", "G48", ",", "we", "investigated", "the", "A15", ":", "U48", "and", "A15", ":", "A48", "variants", "of", "tRNA(Gly", ")", "which", "harbored", "specific", "substitutions", "of", "A13", ":", "A22", ".", "We", "show", "here", "that", "introduction", "of", "A13", ":", "A22", "to", "both", "tRNA", "frameworks", "confers", "structural", "features", "similar", "to", "those", "of", "G15", ":", "G48", "in", "E.", "coli", "tRNA(Cys", ")", ".", "These", "structural", "features", "are", "accompanied", "by", "efficient", "recognition", "of", "both", "tRNAs", "by", "cysteine", "tRNA", "synthetase", ".", "Substitution", "of", "A13", ":", "A22", "with", "U13", ":", "A22", "alters", "the", "structural", "features", "at", "15:48", "and", "impairs", "tRNA", "recognition", ".", "The", "dependence", "on", "A13:22", "for", "tRNA", "recognition", "has", "a", "distinct", "similarity", "to", "that", "of", "E.", "coli", "tRNA(Cys", ")", "and", "to", "that", "of", "the", "G15", ":", "G48", "variant", "of", "tRNA(Gly", ")", ".", "The", "results", "have", "implications", "for", "the", "design", "and", "manipulation", "of", "RNA", "structural", "elements", "as", "the", "basis", "for", "tRNA", "recognition", ".", "\n" ]	[ "Protein" ]
frequency is an umlsterm, hemochromatosis is an umlsterm, population is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, arthropathy is an umlsterm, patients is an umlsterm, rheumatology is an umlsterm, outpatient clinics is an umlsterm, patients is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, disorders is an umlsterm, All is an umlsterm, dysfunction is an umlsterm, iron overload is an umlsterm, life expectancy is an umlsterm, knowledge is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, complications is an umlsterm, iron overload is an umlsterm, patients is an umlsterm	ZfuerRheumatologie.70560156.eng.abstr_task0	Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .	[ "Recent", "studies", "have", "shown", "a", "high", "frequency", "of", "genetic", "hemochromatosis", "in", "the", "Caucasion", "population", ".", "In", "addition", ",", "the", "well", "known", "organ", "involvement", "of", "genetic", "hemochromatosis", "was", "evident", ";", "more", "than", "50", "%", "of", "patients", "develop", "a", "typical", "arthropathy", "which", "may", "result", "in", "severe", "physical", "disability", ".", "Among", "approximately", "5000", "patients", "referred", "to", "the", "rheumatology", "outpatient", "clinics", "of", "Bad", "Nauheim", "and", "Frankfurt", "with", "different", "rheumatologic", "diagnoses", ",", "11", "patients", "with", "typical", "signs", "of", "hemochromatotic", "arthropathy", "were", "identified", ".", "In", "none", "of", "those", "cases", "had", "the", "diagnosis", "\"", "genetic", "hemochromatosis", "\"", "been", "previously", "established", ".", "These", "patients", "had", "been", "treated", "for", "rheumatoid", "arthritis", "and", "other", "rheumatologic", "disorders", "over", "several", "years", ".", "All", "showed", "severe", "organ", "dysfunction", "due", "to", "iron", "overload", ",", "resulting", "in", "a", "reduced", "life", "expectancy", ".", "This", "investigation", "shows", "that", "knowledge", "of", "the", "typical", "signs", "of", "hemochromatotic", "arthropathy", "could", "lead", "to", "an", "earlier", "diagnosis", "of", "genetic", "hemochromatosis", "which", "is", "necessary", "to", "prevent", "the", "complications", "of", "iron", "overload", "in", "those", "patients", "." ]	[ "umlsterm" ]
frequency is an umlsterm, hemochromatosis is an umlsterm, population is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, arthropathy is an umlsterm, patients is an umlsterm, rheumatology is an umlsterm, outpatient clinics is an umlsterm, patients is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, disorders is an umlsterm, All is an umlsterm, dysfunction is an umlsterm, iron overload is an umlsterm, life expectancy is an umlsterm, knowledge is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, complications is an umlsterm, iron overload is an umlsterm, patients is an umlsterm	ZfuerRheumatologie.70560156.eng.abstr_task1	Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please typing these entity words according to sentence: frequency, hemochromatosis, population, hemochromatosis, patients, arthropathy, patients, rheumatology, outpatient clinics, patients, signs, arthropathy, diagnosis, hemochromatosis, patients, rheumatoid arthritis, disorders, All, dysfunction, iron overload, life expectancy, knowledge, signs, arthropathy, diagnosis, hemochromatosis, complications, iron overload, patients Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .	[ "Recent", "studies", "have", "shown", "a", "high", "frequency", "of", "genetic", "hemochromatosis", "in", "the", "Caucasion", "population", ".", "In", "addition", ",", "the", "well", "known", "organ", "involvement", "of", "genetic", "hemochromatosis", "was", "evident", ";", "more", "than", "50", "%", "of", "patients", "develop", "a", "typical", "arthropathy", "which", "may", "result", "in", "severe", "physical", "disability", ".", "Among", "approximately", "5000", "patients", "referred", "to", "the", "rheumatology", "outpatient", "clinics", "of", "Bad", "Nauheim", "and", "Frankfurt", "with", "different", "rheumatologic", "diagnoses", ",", "11", "patients", "with", "typical", "signs", "of", "hemochromatotic", "arthropathy", "were", "identified", ".", "In", "none", "of", "those", "cases", "had", "the", "diagnosis", "\"", "genetic", "hemochromatosis", "\"", "been", "previously", "established", ".", "These", "patients", "had", "been", "treated", "for", "rheumatoid", "arthritis", "and", "other", "rheumatologic", "disorders", "over", "several", "years", ".", "All", "showed", "severe", "organ", "dysfunction", "due", "to", "iron", "overload", ",", "resulting", "in", "a", "reduced", "life", "expectancy", ".", "This", "investigation", "shows", "that", "knowledge", "of", "the", "typical", "signs", "of", "hemochromatotic", "arthropathy", "could", "lead", "to", "an", "earlier", "diagnosis", "of", "genetic", "hemochromatosis", "which", "is", "necessary", "to", "prevent", "the", "complications", "of", "iron", "overload", "in", "those", "patients", "." ]	[ "umlsterm" ]
frequency, hemochromatosis, population, hemochromatosis, patients, arthropathy, patients, rheumatology, outpatient clinics, patients, signs, arthropathy, diagnosis, hemochromatosis, patients, rheumatoid arthritis, disorders, All, dysfunction, iron overload, life expectancy, knowledge, signs, arthropathy, diagnosis, hemochromatosis, complications, iron overload, patients	ZfuerRheumatologie.70560156.eng.abstr_task2	Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .	[ "Recent", "studies", "have", "shown", "a", "high", "frequency", "of", "genetic", "hemochromatosis", "in", "the", "Caucasion", "population", ".", "In", "addition", ",", "the", "well", "known", "organ", "involvement", "of", "genetic", "hemochromatosis", "was", "evident", ";", "more", "than", "50", "%", "of", "patients", "develop", "a", "typical", "arthropathy", "which", "may", "result", "in", "severe", "physical", "disability", ".", "Among", "approximately", "5000", "patients", "referred", "to", "the", "rheumatology", "outpatient", "clinics", "of", "Bad", "Nauheim", "and", "Frankfurt", "with", "different", "rheumatologic", "diagnoses", ",", "11", "patients", "with", "typical", "signs", "of", "hemochromatotic", "arthropathy", "were", "identified", ".", "In", "none", "of", "those", "cases", "had", "the", "diagnosis", "\"", "genetic", "hemochromatosis", "\"", "been", "previously", "established", ".", "These", "patients", "had", "been", "treated", "for", "rheumatoid", "arthritis", "and", "other", "rheumatologic", "disorders", "over", "several", "years", ".", "All", "showed", "severe", "organ", "dysfunction", "due", "to", "iron", "overload", ",", "resulting", "in", "a", "reduced", "life", "expectancy", ".", "This", "investigation", "shows", "that", "knowledge", "of", "the", "typical", "signs", "of", "hemochromatotic", "arthropathy", "could", "lead", "to", "an", "earlier", "diagnosis", "of", "genetic", "hemochromatosis", "which", "is", "necessary", "to", "prevent", "the", "complications", "of", "iron", "overload", "in", "those", "patients", "." ]	[ "umlsterm" ]
Behandlung is an umlsterm, Lysosomen is an umlsterm, Zellen is an umlsterm, Patienten is an umlsterm	DerOpthalmologe.70940147.ger.abstr_task0	Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .	[ "Hintergrund", ":", "Die", "Chloroquinkeratopathie", "ist", "als", "eine", "reversible", "epitheliale", "Hornhauteinlagerung", "bekannt", ",", "die", "ohne", "direkten", "Zusammenhang", "mit", "der", "Dauer", "und", "Dosierung", "der", "Behandlung", "auftritt", ".", "Dabei", "kommt", "es", "zu", "einer", "Anreicherung", "von", "Chloroquin", "in", "den", "Lysosomen", "der", "Zellen", ".", "Ziel", "unserer", "Untersuchungen", "war", "es", ",", "mikroskopische", "Veraenderungen", "der", "Hornhaut", "bei", "Patienten", "infolge", "einer", "Chloroquintherapie", "in", "vivo", "zu", "erfassen", "." ]	[ "umlsterm" ]
Behandlung is an umlsterm, Lysosomen is an umlsterm, Zellen is an umlsterm, Patienten is an umlsterm	DerOpthalmologe.70940147.ger.abstr_task1	Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please typing these entity words according to sentence: Behandlung, Lysosomen, Zellen, Patienten Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .	[ "Hintergrund", ":", "Die", "Chloroquinkeratopathie", "ist", "als", "eine", "reversible", "epitheliale", "Hornhauteinlagerung", "bekannt", ",", "die", "ohne", "direkten", "Zusammenhang", "mit", "der", "Dauer", "und", "Dosierung", "der", "Behandlung", "auftritt", ".", "Dabei", "kommt", "es", "zu", "einer", "Anreicherung", "von", "Chloroquin", "in", "den", "Lysosomen", "der", "Zellen", ".", "Ziel", "unserer", "Untersuchungen", "war", "es", ",", "mikroskopische", "Veraenderungen", "der", "Hornhaut", "bei", "Patienten", "infolge", "einer", "Chloroquintherapie", "in", "vivo", "zu", "erfassen", "." ]	[ "umlsterm" ]
Behandlung, Lysosomen, Zellen, Patienten	DerOpthalmologe.70940147.ger.abstr_task2	Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .	[ "Hintergrund", ":", "Die", "Chloroquinkeratopathie", "ist", "als", "eine", "reversible", "epitheliale", "Hornhauteinlagerung", "bekannt", ",", "die", "ohne", "direkten", "Zusammenhang", "mit", "der", "Dauer", "und", "Dosierung", "der", "Behandlung", "auftritt", ".", "Dabei", "kommt", "es", "zu", "einer", "Anreicherung", "von", "Chloroquin", "in", "den", "Lysosomen", "der", "Zellen", ".", "Ziel", "unserer", "Untersuchungen", "war", "es", ",", "mikroskopische", "Veraenderungen", "der", "Hornhaut", "bei", "Patienten", "infolge", "einer", "Chloroquintherapie", "in", "vivo", "zu", "erfassen", "." ]	[ "umlsterm" ]
verhaltenstherapeutisch is an umlsterm, Psychotherapie is an umlsterm, Personalbemessung is an umlsterm, Methodik is an umlsterm, Therapie is an umlsterm, Teamtherapie is an umlsterm, Gruppentherapie is an umlsterm, verhaltenstherapeutischen is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Psychotherapie is an umlsterm, verhaltenstherapeutische is an umlsterm, Methoden is an umlsterm	Psychotherapeut.80430265.ger.abstr_task0	Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .	[ "In", "dieser", "Uebersichtsarbeit", "wird", "die", "Entwicklung", "der", "psychoanalytisch", "und", "verhaltenstherapeutisch", "begruendeten", "stationaeren", "Psychotherapie", "als", "eigenstaendiger", "spezieller", "Versorgungsbereich", "fuer", "sogenannte", "psychogene", "Stoerungen", "dargestellt", ".", "Die", "strukturellen", "Eckdaten", "wie", "Groesse", "der", "Einrichtungen", "als", "Abteilung", "oder", "Fachklinik", ",", "Finanzierung", ",", "Verweildauer", "und", "Personalbemessung", "werden", "diskutiert", ".", "Ein", "Schwerpunkt", "wird", "auf", "die", "Entwicklung", "der", "Methodik", "gelegt", ".", "In", "den", "psychoanalytisch", "begruendeten", "Konzepten", "steht", "gemaess", "der", "psychoanalytischen", "Therapie", "die", "multimodale", "Teamtherapie", "unter", "Beruecksichtigung", "der", "multidimensionalen", "Uebertragungsprozesse", "mit", "dem", "Schwerpunkt", "auf", "Gruppentherapie", "im", "Vordergrund", ".", "In", "den", "verhaltenstherapeutischen", "Konzepten", "stehen", "die", "stoerungsspezifischen", ",", "psychoedukativen", ",", "einzel-", "und", "gruppentherapeutischen", "Konzepte", "mit", "dem", "zentralen", "Ziel", ",", "das", "Selbstmanagement", "des", "Patienten", "fuer", "seine", "Erkrankung", "zu", "verbessern", "im", "Vordergrund", ".", "In", "der", "juengsten", "Zeit", "werden", "in", "der", "psychoanalytisch", "begruendeten", "stationaeren", "Psychotherapie", "zunehmend", "verhaltenstherapeutische", "Methoden", "integriert", "und", "umgekehrt", "." ]	[ "umlsterm" ]
verhaltenstherapeutisch is an umlsterm, Psychotherapie is an umlsterm, Personalbemessung is an umlsterm, Methodik is an umlsterm, Therapie is an umlsterm, Teamtherapie is an umlsterm, Gruppentherapie is an umlsterm, verhaltenstherapeutischen is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Psychotherapie is an umlsterm, verhaltenstherapeutische is an umlsterm, Methoden is an umlsterm	Psychotherapeut.80430265.ger.abstr_task1	Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please typing these entity words according to sentence: verhaltenstherapeutisch, Psychotherapie, Personalbemessung, Methodik, Therapie, Teamtherapie, Gruppentherapie, verhaltenstherapeutischen, Patienten, Zeit, Psychotherapie, verhaltenstherapeutische, Methoden Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .	[ "In", "dieser", "Uebersichtsarbeit", "wird", "die", "Entwicklung", "der", "psychoanalytisch", "und", "verhaltenstherapeutisch", "begruendeten", "stationaeren", "Psychotherapie", "als", "eigenstaendiger", "spezieller", "Versorgungsbereich", "fuer", "sogenannte", "psychogene", "Stoerungen", "dargestellt", ".", "Die", "strukturellen", "Eckdaten", "wie", "Groesse", "der", "Einrichtungen", "als", "Abteilung", "oder", "Fachklinik", ",", "Finanzierung", ",", "Verweildauer", "und", "Personalbemessung", "werden", "diskutiert", ".", "Ein", "Schwerpunkt", "wird", "auf", "die", "Entwicklung", "der", "Methodik", "gelegt", ".", "In", "den", "psychoanalytisch", "begruendeten", "Konzepten", "steht", "gemaess", "der", "psychoanalytischen", "Therapie", "die", "multimodale", "Teamtherapie", "unter", "Beruecksichtigung", "der", "multidimensionalen", "Uebertragungsprozesse", "mit", "dem", "Schwerpunkt", "auf", "Gruppentherapie", "im", "Vordergrund", ".", "In", "den", "verhaltenstherapeutischen", "Konzepten", "stehen", "die", "stoerungsspezifischen", ",", "psychoedukativen", ",", "einzel-", "und", "gruppentherapeutischen", "Konzepte", "mit", "dem", "zentralen", "Ziel", ",", "das", "Selbstmanagement", "des", "Patienten", "fuer", "seine", "Erkrankung", "zu", "verbessern", "im", "Vordergrund", ".", "In", "der", "juengsten", "Zeit", "werden", "in", "der", "psychoanalytisch", "begruendeten", "stationaeren", "Psychotherapie", "zunehmend", "verhaltenstherapeutische", "Methoden", "integriert", "und", "umgekehrt", "." ]	[ "umlsterm" ]
verhaltenstherapeutisch, Psychotherapie, Personalbemessung, Methodik, Therapie, Teamtherapie, Gruppentherapie, verhaltenstherapeutischen, Patienten, Zeit, Psychotherapie, verhaltenstherapeutische, Methoden	Psychotherapeut.80430265.ger.abstr_task2	Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .	[ "In", "dieser", "Uebersichtsarbeit", "wird", "die", "Entwicklung", "der", "psychoanalytisch", "und", "verhaltenstherapeutisch", "begruendeten", "stationaeren", "Psychotherapie", "als", "eigenstaendiger", "spezieller", "Versorgungsbereich", "fuer", "sogenannte", "psychogene", "Stoerungen", "dargestellt", ".", "Die", "strukturellen", "Eckdaten", "wie", "Groesse", "der", "Einrichtungen", "als", "Abteilung", "oder", "Fachklinik", ",", "Finanzierung", ",", "Verweildauer", "und", "Personalbemessung", "werden", "diskutiert", ".", "Ein", "Schwerpunkt", "wird", "auf", "die", "Entwicklung", "der", "Methodik", "gelegt", ".", "In", "den", "psychoanalytisch", "begruendeten", "Konzepten", "steht", "gemaess", "der", "psychoanalytischen", "Therapie", "die", "multimodale", "Teamtherapie", "unter", "Beruecksichtigung", "der", "multidimensionalen", "Uebertragungsprozesse", "mit", "dem", "Schwerpunkt", "auf", "Gruppentherapie", "im", "Vordergrund", ".", "In", "den", "verhaltenstherapeutischen", "Konzepten", "stehen", "die", "stoerungsspezifischen", ",", "psychoedukativen", ",", "einzel-", "und", "gruppentherapeutischen", "Konzepte", "mit", "dem", "zentralen", "Ziel", ",", "das", "Selbstmanagement", "des", "Patienten", "fuer", "seine", "Erkrankung", "zu", "verbessern", "im", "Vordergrund", ".", "In", "der", "juengsten", "Zeit", "werden", "in", "der", "psychoanalytisch", "begruendeten", "stationaeren", "Psychotherapie", "zunehmend", "verhaltenstherapeutische", "Methoden", "integriert", "und", "umgekehrt", "." ]	[ "umlsterm" ]
Sitagliptin is a CHEMICAL	17352516_task0	Sentence: Sitagliptin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "B-CHEMICAL", "O" ]	Sitagliptin.	[ "Sitagliptin", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Sitagliptin is a CHEMICAL	17352516_task1	Sentence: Sitagliptin. Instructions: please typing these entity words according to sentence: Sitagliptin Options: CHEMICAL	[ "B-CHEMICAL", "O" ]	Sitagliptin.	[ "Sitagliptin", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Sitagliptin	17352516_task2	Sentence: Sitagliptin. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O" ]	Sitagliptin.	[ "Sitagliptin", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
out - of - pocket costs is an outcome, time on caregiving activities is an outcome	958_task0	Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: outcome	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O" ]	In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .	[ "In", "adjusted", "analyses", ",", "parents", "who", "reported", "that", "their", "child", "had", "ASD", "did", "not", "have", "significantly", "higher", "out", "-", "of", "-", "pocket", "costs", "or", "spend", "more", "time", "on", "caregiving", "activities", "compared", "with", "control", "parents", "." ]	[ "outcome" ]
out - of - pocket costs is an outcome, time on caregiving activities is an outcome	958_task1	Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please typing these entity words according to sentence: out - of - pocket costs, time on caregiving activities Options: outcome	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O" ]	In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .	[ "In", "adjusted", "analyses", ",", "parents", "who", "reported", "that", "their", "child", "had", "ASD", "did", "not", "have", "significantly", "higher", "out", "-", "of", "-", "pocket", "costs", "or", "spend", "more", "time", "on", "caregiving", "activities", "compared", "with", "control", "parents", "." ]	[ "outcome" ]
out - of - pocket costs, time on caregiving activities	958_task2	Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O" ]	In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .	[ "In", "adjusted", "analyses", ",", "parents", "who", "reported", "that", "their", "child", "had", "ASD", "did", "not", "have", "significantly", "higher", "out", "-", "of", "-", "pocket", "costs", "or", "spend", "more", "time", "on", "caregiving", "activities", "compared", "with", "control", "parents", "." ]	[ "outcome" ]
citoqueratinas is a PROTEINAS, vimentina is a PROTEINAS	16_task0	Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.	[ "Varón", "de", "80", "años", "que", "debutó", "clínicamente", "con", "hematuria", "y", "dolor", "en", "flanco", "izquierdo", ".", "La", "puñopercusión", "en", "fosa", "renal", "izquierda", "fue", "positiva", ".", "Mediante", "técnicas", "de", "imagen", "se", "observó", "una", "masa", "a", "nivel", "de", "fosa", "renal", "izquierda", "que", "desdibujaba", "la", "silueta", "renal", ".", "El", "paciente", "fue", "intervenido", "realizándose", "una", "nefrectomía", "con", "ureterectomía", "proximal", ".", "\n", "En", "la", "pieza", "de", "nefrectomía", "el", "parénquima", "renal", "estaba", "sustituido", "en", "su", "práctica", "totalidad", "por", "una", "lesión", "blanquecina", "heterogénea", "en", "cuyo", "seno", "se", "podían", "apreciar", "cavidades", "quísticas", "de", "aspecto", "necrótico", "con", "formaciones", "papilares", "friables", "y", "mal", "delimitadas", "intracavitarias", "y", "áreas", "amarillentas", "mal", "delimitadas", "combinadas", "al", "azar", "con", "otras", "de", "aspecto", "necrótico", "y", "/", "o", "hemorrágico", ".", "Al", "corte", "se", "observó", "una", "consistencia", "firme", ",", "fundamentalmente", "correspondiendo", "con", "las", "áreas", "blanquecinogrisaceas", "si", "bien", "en", "otras", "localizaciones", "se", "apreció", "una", "consistencia", "blanda", "e", "incluso", "crujiente", ".", "\n", "El", "estudio", "histológico", "demostró", "una", "neoplasia", "constituida", "por", "una", "proliferación", "de", "células", "fusiformes", "y", "poligonales", "con", "marcada", "atípia", "y", "pleomorfismo", "nuclear", ",", "que", "adoptaba", "un", "patrón", "sólido", "de", "crecimiento", ".", "Más", "del", "75", "%", "de", "la", "misma", "mostraba", "diferenciación", "a", "osteo", "y", "condrosarcoma", "si", "bien", "también", "se", "pudo", "demostrar", "diferenciación", "escamosa", ",", "principalmente", "tapizando", "la", "superficie", "interna", "de", "las", "formaciones", "quísticas", "previamente", "descritas", ".", "La", "elevada", "atipia", "celular", "observada", "se", "hacía", "más", "evidente", "con", "la", "presencia", "de", "abundantes", "células", "gigantes", "multinucleadas", "situadas", "en", "el", "seno", "de", "las", "áreas", "sólidas", "fusiformes", "y", "en", "torno", "a", "las", "áreas", "de", "diferenciación", "osteosarcomatosa", "(", "14", ")", "(", "seguramente", "estas", "últimas", "sean", "en", "realidad", "osteoclastos", "atípicos", ")", ".", "El", "tumor", "contactaba", "con", "la", "cápsula", "renal", "sin", "sobrepasarla", ",", "invadiendo", "estructuras", "vasculares", "del", "hilio", "y", "el", "tejido", "adiposo", "de", "la", "pelvis", ".", "Tras", "un", "muestreo", "riguroso", "de", "la", "pieza", "quirúrgica", "se", "pudieron", "objetivar", "escasos", "focos", "con", "patrón", "histológico", "de", "carcinoma", "de", "células", "claras", ".", "El", "estudio", "inmunohistoquímico", "de", "la", "neoplasia", "mostró", "inmunotinción", "positiva", "para", "citoqueratinas", "tanto", "en", "el", "componente", "de", "células", "claras", "como", "en", "el", "fusocelular", "siendo", "este", "último", "igualmente", "positivo", "para", "vimentina", "(", "13", ")", ".", "Con", "todo", "ello", "se", "emitió", "el", "diagnóstico", "de", "carcinoma", "sarcomatoide", "renal", "con", "predominio", "de", "áreas", "con", "diferenciación", "heteróloga", "maligna", "(", "osteo", "y", "condrosarcoma", ")", ",", "haciendo", "referencia", "a", "la", "presencia", "de", "focos", "de", "carcinoma", "con", "patrón", "de", "células", "claras", "y", "de", "áreas", "con", "diferenciación", "escamosa", ".", "\n\n" ]	[ "PROTEINAS" ]
citoqueratinas is a PROTEINAS, vimentina is a PROTEINAS	16_task1	Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please typing these entity words according to sentence: citoqueratinas, vimentina Options: PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.	[ "Varón", "de", "80", "años", "que", "debutó", "clínicamente", "con", "hematuria", "y", "dolor", "en", "flanco", "izquierdo", ".", "La", "puñopercusión", "en", "fosa", "renal", "izquierda", "fue", "positiva", ".", "Mediante", "técnicas", "de", "imagen", "se", "observó", "una", "masa", "a", "nivel", "de", "fosa", "renal", "izquierda", "que", "desdibujaba", "la", "silueta", "renal", ".", "El", "paciente", "fue", "intervenido", "realizándose", "una", "nefrectomía", "con", "ureterectomía", "proximal", ".", "\n", "En", "la", "pieza", "de", "nefrectomía", "el", "parénquima", "renal", "estaba", "sustituido", "en", "su", "práctica", "totalidad", "por", "una", "lesión", "blanquecina", "heterogénea", "en", "cuyo", "seno", "se", "podían", "apreciar", "cavidades", "quísticas", "de", "aspecto", "necrótico", "con", "formaciones", "papilares", "friables", "y", "mal", "delimitadas", "intracavitarias", "y", "áreas", "amarillentas", "mal", "delimitadas", "combinadas", "al", "azar", "con", "otras", "de", "aspecto", "necrótico", "y", "/", "o", "hemorrágico", ".", "Al", "corte", "se", "observó", "una", "consistencia", "firme", ",", "fundamentalmente", "correspondiendo", "con", "las", "áreas", "blanquecinogrisaceas", "si", "bien", "en", "otras", "localizaciones", "se", "apreció", "una", "consistencia", "blanda", "e", "incluso", "crujiente", ".", "\n", "El", "estudio", "histológico", "demostró", "una", "neoplasia", "constituida", "por", "una", "proliferación", "de", "células", "fusiformes", "y", "poligonales", "con", "marcada", "atípia", "y", "pleomorfismo", "nuclear", ",", "que", "adoptaba", "un", "patrón", "sólido", "de", "crecimiento", ".", "Más", "del", "75", "%", "de", "la", "misma", "mostraba", "diferenciación", "a", "osteo", "y", "condrosarcoma", "si", "bien", "también", "se", "pudo", "demostrar", "diferenciación", "escamosa", ",", "principalmente", "tapizando", "la", "superficie", "interna", "de", "las", "formaciones", "quísticas", "previamente", "descritas", ".", "La", "elevada", "atipia", "celular", "observada", "se", "hacía", "más", "evidente", "con", "la", "presencia", "de", "abundantes", "células", "gigantes", "multinucleadas", "situadas", "en", "el", "seno", "de", "las", "áreas", "sólidas", "fusiformes", "y", "en", "torno", "a", "las", "áreas", "de", "diferenciación", "osteosarcomatosa", "(", "14", ")", "(", "seguramente", "estas", "últimas", "sean", "en", "realidad", "osteoclastos", "atípicos", ")", ".", "El", "tumor", "contactaba", "con", "la", "cápsula", "renal", "sin", "sobrepasarla", ",", "invadiendo", "estructuras", "vasculares", "del", "hilio", "y", "el", "tejido", "adiposo", "de", "la", "pelvis", ".", "Tras", "un", "muestreo", "riguroso", "de", "la", "pieza", "quirúrgica", "se", "pudieron", "objetivar", "escasos", "focos", "con", "patrón", "histológico", "de", "carcinoma", "de", "células", "claras", ".", "El", "estudio", "inmunohistoquímico", "de", "la", "neoplasia", "mostró", "inmunotinción", "positiva", "para", "citoqueratinas", "tanto", "en", "el", "componente", "de", "células", "claras", "como", "en", "el", "fusocelular", "siendo", "este", "último", "igualmente", "positivo", "para", "vimentina", "(", "13", ")", ".", "Con", "todo", "ello", "se", "emitió", "el", "diagnóstico", "de", "carcinoma", "sarcomatoide", "renal", "con", "predominio", "de", "áreas", "con", "diferenciación", "heteróloga", "maligna", "(", "osteo", "y", "condrosarcoma", ")", ",", "haciendo", "referencia", "a", "la", "presencia", "de", "focos", "de", "carcinoma", "con", "patrón", "de", "células", "claras", "y", "de", "áreas", "con", "diferenciación", "escamosa", ".", "\n\n" ]	[ "PROTEINAS" ]
citoqueratinas, vimentina	16_task2	Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.	[ "Varón", "de", "80", "años", "que", "debutó", "clínicamente", "con", "hematuria", "y", "dolor", "en", "flanco", "izquierdo", ".", "La", "puñopercusión", "en", "fosa", "renal", "izquierda", "fue", "positiva", ".", "Mediante", "técnicas", "de", "imagen", "se", "observó", "una", "masa", "a", "nivel", "de", "fosa", "renal", "izquierda", "que", "desdibujaba", "la", "silueta", "renal", ".", "El", "paciente", "fue", "intervenido", "realizándose", "una", "nefrectomía", "con", "ureterectomía", "proximal", ".", "\n", "En", "la", "pieza", "de", "nefrectomía", "el", "parénquima", "renal", "estaba", "sustituido", "en", "su", "práctica", "totalidad", "por", "una", "lesión", "blanquecina", "heterogénea", "en", "cuyo", "seno", "se", "podían", "apreciar", "cavidades", "quísticas", "de", "aspecto", "necrótico", "con", "formaciones", "papilares", "friables", "y", "mal", "delimitadas", "intracavitarias", "y", "áreas", "amarillentas", "mal", "delimitadas", "combinadas", "al", "azar", "con", "otras", "de", "aspecto", "necrótico", "y", "/", "o", "hemorrágico", ".", "Al", "corte", "se", "observó", "una", "consistencia", "firme", ",", "fundamentalmente", "correspondiendo", "con", "las", "áreas", "blanquecinogrisaceas", "si", "bien", "en", "otras", "localizaciones", "se", "apreció", "una", "consistencia", "blanda", "e", "incluso", "crujiente", ".", "\n", "El", "estudio", "histológico", "demostró", "una", "neoplasia", "constituida", "por", "una", "proliferación", "de", "células", "fusiformes", "y", "poligonales", "con", "marcada", "atípia", "y", "pleomorfismo", "nuclear", ",", "que", "adoptaba", "un", "patrón", "sólido", "de", "crecimiento", ".", "Más", "del", "75", "%", "de", "la", "misma", "mostraba", "diferenciación", "a", "osteo", "y", "condrosarcoma", "si", "bien", "también", "se", "pudo", "demostrar", "diferenciación", "escamosa", ",", "principalmente", "tapizando", "la", "superficie", "interna", "de", "las", "formaciones", "quísticas", "previamente", "descritas", ".", "La", "elevada", "atipia", "celular", "observada", "se", "hacía", "más", "evidente", "con", "la", "presencia", "de", "abundantes", "células", "gigantes", "multinucleadas", "situadas", "en", "el", "seno", "de", "las", "áreas", "sólidas", "fusiformes", "y", "en", "torno", "a", "las", "áreas", "de", "diferenciación", "osteosarcomatosa", "(", "14", ")", "(", "seguramente", "estas", "últimas", "sean", "en", "realidad", "osteoclastos", "atípicos", ")", ".", "El", "tumor", "contactaba", "con", "la", "cápsula", "renal", "sin", "sobrepasarla", ",", "invadiendo", "estructuras", "vasculares", "del", "hilio", "y", "el", "tejido", "adiposo", "de", "la", "pelvis", ".", "Tras", "un", "muestreo", "riguroso", "de", "la", "pieza", "quirúrgica", "se", "pudieron", "objetivar", "escasos", "focos", "con", "patrón", "histológico", "de", "carcinoma", "de", "células", "claras", ".", "El", "estudio", "inmunohistoquímico", "de", "la", "neoplasia", "mostró", "inmunotinción", "positiva", "para", "citoqueratinas", "tanto", "en", "el", "componente", "de", "células", "claras", "como", "en", "el", "fusocelular", "siendo", "este", "último", "igualmente", "positivo", "para", "vimentina", "(", "13", ")", ".", "Con", "todo", "ello", "se", "emitió", "el", "diagnóstico", "de", "carcinoma", "sarcomatoide", "renal", "con", "predominio", "de", "áreas", "con", "diferenciación", "heteróloga", "maligna", "(", "osteo", "y", "condrosarcoma", ")", ",", "haciendo", "referencia", "a", "la", "presencia", "de", "focos", "de", "carcinoma", "con", "patrón", "de", "células", "claras", "y", "de", "áreas", "con", "diferenciación", "escamosa", ".", "\n\n" ]	[ "PROTEINAS" ]
aim is an umlsterm, evaluation is an umlsterm, radiotranslucent is an umlsterm, headholder is an umlsterm, diagnosis is an umlsterm, pathology is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, pathology is an umlsterm, Philips is an umlsterm, apparatus is an umlsterm, head is an umlsterm, control group is an umlsterm, patients is an umlsterm, pathology is an umlsterm, computed tomography is an umlsterm, headholder is an umlsterm, findings is an umlsterm, CT scans is an umlsterm, assessment is an umlsterm, disease is an umlsterm, motion is an umlsterm, artifacts is an umlsterm, posture is an umlsterm, head is an umlsterm, headholder is an umlsterm, diagnosis is an umlsterm, computed tomography is an umlsterm, posture is an umlsterm, head is an umlsterm, motion is an umlsterm, artifacts is an umlsterm	MundKieferGesichtschirurgie.8002s135.eng.abstr_task0	Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .	[ "The", "aim", "of", "this", "study", "was", "the", "evaluation", "of", "a", "newly", "developed", "radiotranslucent", "headholder", "(", "craniostat", ")", "in", "order", "to", "improve", "diagnosis", "of", "maxillofacial", "pathology", ".", "In", "this", "prospective", "study", ",", "103", "patients", "with", "maxillofacial", "pathology", "were", "examined", "preoperatively", "with", "a", "Philips", "SR", "7000", "computed", "tomograph", "using", "this", "craniostat", ".", "The", "apparatus", "was", "applied", "fixing", "the", "patient", "'s", "head", "at", "three", "points", "(", "meatus", "acusticus", "externus", "on", "both", "sides", "and", "the", "glabella", ")", ".", "The", "control", "group", "consisted", "of", "106", "patients", "with", "similar", "pathology", "who", "were", "examined", "by", "computed", "tomography", "without", "a", "headholder", ".", "The", "application", "of", "the", "craniostat", "resulted", "in", "the", "following", "advantageous", "findings", ":", "(", "1", ")", "reproducible", "CT", "scans", ",", "therefore", "very", "precise", "assessment", "of", "the", "course", "of", "a", "disease", ";", "(", "2", ")", "fewer", "motion", "artifacts", ";", "and", "(", "3", ")", "symmetrical", "posture", "of", "the", "patient", "'s", "head", ".", "This", "headholder", "is", "helpful", "in", "improving", "maxillofacial", "diagnosis", "by", "computed", "tomography", "if", "a", "symmetrical", ",", "reproducible", "posture", "of", "the", "patient", "'s", "head", "is", "to", "be", "achieved", "and", "motion", "artifacts", "could", "otherwise", "make", "the", "interpretation", "of", "the", "resulting", "images", "much", "more", "difficult", "." ]	[ "umlsterm" ]
aim is an umlsterm, evaluation is an umlsterm, radiotranslucent is an umlsterm, headholder is an umlsterm, diagnosis is an umlsterm, pathology is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, pathology is an umlsterm, Philips is an umlsterm, apparatus is an umlsterm, head is an umlsterm, control group is an umlsterm, patients is an umlsterm, pathology is an umlsterm, computed tomography is an umlsterm, headholder is an umlsterm, findings is an umlsterm, CT scans is an umlsterm, assessment is an umlsterm, disease is an umlsterm, motion is an umlsterm, artifacts is an umlsterm, posture is an umlsterm, head is an umlsterm, headholder is an umlsterm, diagnosis is an umlsterm, computed tomography is an umlsterm, posture is an umlsterm, head is an umlsterm, motion is an umlsterm, artifacts is an umlsterm	MundKieferGesichtschirurgie.8002s135.eng.abstr_task1	Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please typing these entity words according to sentence: aim, evaluation, radiotranslucent, headholder, diagnosis, pathology, prospective study, patients, pathology, Philips, apparatus, head, control group, patients, pathology, computed tomography, headholder, findings, CT scans, assessment, disease, motion, artifacts, posture, head, headholder, diagnosis, computed tomography, posture, head, motion, artifacts Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .	[ "The", "aim", "of", "this", "study", "was", "the", "evaluation", "of", "a", "newly", "developed", "radiotranslucent", "headholder", "(", "craniostat", ")", "in", "order", "to", "improve", "diagnosis", "of", "maxillofacial", "pathology", ".", "In", "this", "prospective", "study", ",", "103", "patients", "with", "maxillofacial", "pathology", "were", "examined", "preoperatively", "with", "a", "Philips", "SR", "7000", "computed", "tomograph", "using", "this", "craniostat", ".", "The", "apparatus", "was", "applied", "fixing", "the", "patient", "'s", "head", "at", "three", "points", "(", "meatus", "acusticus", "externus", "on", "both", "sides", "and", "the", "glabella", ")", ".", "The", "control", "group", "consisted", "of", "106", "patients", "with", "similar", "pathology", "who", "were", "examined", "by", "computed", "tomography", "without", "a", "headholder", ".", "The", "application", "of", "the", "craniostat", "resulted", "in", "the", "following", "advantageous", "findings", ":", "(", "1", ")", "reproducible", "CT", "scans", ",", "therefore", "very", "precise", "assessment", "of", "the", "course", "of", "a", "disease", ";", "(", "2", ")", "fewer", "motion", "artifacts", ";", "and", "(", "3", ")", "symmetrical", "posture", "of", "the", "patient", "'s", "head", ".", "This", "headholder", "is", "helpful", "in", "improving", "maxillofacial", "diagnosis", "by", "computed", "tomography", "if", "a", "symmetrical", ",", "reproducible", "posture", "of", "the", "patient", "'s", "head", "is", "to", "be", "achieved", "and", "motion", "artifacts", "could", "otherwise", "make", "the", "interpretation", "of", "the", "resulting", "images", "much", "more", "difficult", "." ]	[ "umlsterm" ]
aim, evaluation, radiotranslucent, headholder, diagnosis, pathology, prospective study, patients, pathology, Philips, apparatus, head, control group, patients, pathology, computed tomography, headholder, findings, CT scans, assessment, disease, motion, artifacts, posture, head, headholder, diagnosis, computed tomography, posture, head, motion, artifacts	MundKieferGesichtschirurgie.8002s135.eng.abstr_task2	Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .	[ "The", "aim", "of", "this", "study", "was", "the", "evaluation", "of", "a", "newly", "developed", "radiotranslucent", "headholder", "(", "craniostat", ")", "in", "order", "to", "improve", "diagnosis", "of", "maxillofacial", "pathology", ".", "In", "this", "prospective", "study", ",", "103", "patients", "with", "maxillofacial", "pathology", "were", "examined", "preoperatively", "with", "a", "Philips", "SR", "7000", "computed", "tomograph", "using", "this", "craniostat", ".", "The", "apparatus", "was", "applied", "fixing", "the", "patient", "'s", "head", "at", "three", "points", "(", "meatus", "acusticus", "externus", "on", "both", "sides", "and", "the", "glabella", ")", ".", "The", "control", "group", "consisted", "of", "106", "patients", "with", "similar", "pathology", "who", "were", "examined", "by", "computed", "tomography", "without", "a", "headholder", ".", "The", "application", "of", "the", "craniostat", "resulted", "in", "the", "following", "advantageous", "findings", ":", "(", "1", ")", "reproducible", "CT", "scans", ",", "therefore", "very", "precise", "assessment", "of", "the", "course", "of", "a", "disease", ";", "(", "2", ")", "fewer", "motion", "artifacts", ";", "and", "(", "3", ")", "symmetrical", "posture", "of", "the", "patient", "'s", "head", ".", "This", "headholder", "is", "helpful", "in", "improving", "maxillofacial", "diagnosis", "by", "computed", "tomography", "if", "a", "symmetrical", ",", "reproducible", "posture", "of", "the", "patient", "'s", "head", "is", "to", "be", "achieved", "and", "motion", "artifacts", "could", "otherwise", "make", "the", "interpretation", "of", "the", "resulting", "images", "much", "more", "difficult", "." ]	[ "umlsterm" ]
Maternal nutrition is an umlsterm, pregnancy is an umlsterm, lactation is an umlsterm, preventive is an umlsterm, health is an umlsterm, child is an umlsterm, nutritional status is an umlsterm, mother is an umlsterm, nutrition is an umlsterm, weight gain is an umlsterm, Diseases is an umlsterm, mother is an umlsterm, diet is an umlsterm, diabetes mellitus is an umlsterm, maternal PKU is an umlsterm, nutrition is an umlsterm, pregnancy is an umlsterm, 3rd trimester is an umlsterm, energy supply is an umlsterm, minerals is an umlsterm, vitamins is an umlsterm, acids is an umlsterm, iron is an umlsterm, magnesium is an umlsterm, zinc is an umlsterm, iodine is an umlsterm, folic acid is an umlsterm, vitamin is an umlsterm, deficiencies is an umlsterm, pregnancy is an umlsterm, health is an umlsterm, baby is an umlsterm, spontaneous abortions is an umlsterm, prematurity is an umlsterm, low birth weight is an umlsterm, birth defects is an umlsterm, dysfunctions is an umlsterm	MonatsschriftKinderheilkunde.8146s073.eng.abstr_task0	Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .	[ "Maternal", "nutrition", "during", "pregnancy", "and", "lactation", "has", "great", "preventive", "importance", "for", "the", "health", "of", "the", "young", "child", ".", "Important", "determinants", "are", "the", "pregravid", "nutritional", "status", "of", "the", "mother", ",", "the", "quantity", "and", "quality", "of", "the", "nutrition", "and", "gestational", "weight", "gain", ".", "Diseases", "of", "the", "mother", "that", "have", "to", "be", "treated", "by", "a", "special", "diet", "like", "diabetes", "mellitus", "or", "maternal", "PKU", "can", "complicate", "the", "maternal", "situation", ".", "Optimal", "nutrition", "during", "pregnancy", "includes", "at", "least", "in", "the", "2nd", "or", "3rd", "trimester", "increased", "energy", "supply", "(", "+300", "kcal", "/", "day", ")", "and", "an", "increase", "in", "all", "nutrients", ",", "including", "minerals", "and", "vitamins", ".", "Of", "special", "importance", "are", "-3-fatty", "acids", ",", "iron", ",", "magnesium", ",", "zinc", ",", "iodine", ",", "and", "folic", "acid", ",", "vita", "-", "min", "B12", "and", "vitamin", "K.", "Under-", "and", "overnu", "-", "trition", "and", "deficiencies", "in", "the", "above", "nutrients", "may", "have", "an", "influence", "on", "the", "outcome", "of", "pregnancy", "and", "the", "health", "of", "the", "baby", ":", "more", "spontaneous", "abortions", ",", "prematurity", ",", "low", "birth", "weight", ",", "birth", "defects", ",", "intra-", "and", "extrauterine", "developmental", "disturbances", "and", "organ", "dysfunctions", "." ]	[ "umlsterm" ]
Maternal nutrition is an umlsterm, pregnancy is an umlsterm, lactation is an umlsterm, preventive is an umlsterm, health is an umlsterm, child is an umlsterm, nutritional status is an umlsterm, mother is an umlsterm, nutrition is an umlsterm, weight gain is an umlsterm, Diseases is an umlsterm, mother is an umlsterm, diet is an umlsterm, diabetes mellitus is an umlsterm, maternal PKU is an umlsterm, nutrition is an umlsterm, pregnancy is an umlsterm, 3rd trimester is an umlsterm, energy supply is an umlsterm, minerals is an umlsterm, vitamins is an umlsterm, acids is an umlsterm, iron is an umlsterm, magnesium is an umlsterm, zinc is an umlsterm, iodine is an umlsterm, folic acid is an umlsterm, vitamin is an umlsterm, deficiencies is an umlsterm, pregnancy is an umlsterm, health is an umlsterm, baby is an umlsterm, spontaneous abortions is an umlsterm, prematurity is an umlsterm, low birth weight is an umlsterm, birth defects is an umlsterm, dysfunctions is an umlsterm	MonatsschriftKinderheilkunde.8146s073.eng.abstr_task1	Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please typing these entity words according to sentence: Maternal nutrition, pregnancy, lactation, preventive, health, child, nutritional status, mother, nutrition, weight gain, Diseases, mother, diet, diabetes mellitus, maternal PKU, nutrition, pregnancy, 3rd trimester, energy supply, minerals, vitamins, acids, iron, magnesium, zinc, iodine, folic acid, vitamin, deficiencies, pregnancy, health, baby, spontaneous abortions, prematurity, low birth weight, birth defects, dysfunctions Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .	[ "Maternal", "nutrition", "during", "pregnancy", "and", "lactation", "has", "great", "preventive", "importance", "for", "the", "health", "of", "the", "young", "child", ".", "Important", "determinants", "are", "the", "pregravid", "nutritional", "status", "of", "the", "mother", ",", "the", "quantity", "and", "quality", "of", "the", "nutrition", "and", "gestational", "weight", "gain", ".", "Diseases", "of", "the", "mother", "that", "have", "to", "be", "treated", "by", "a", "special", "diet", "like", "diabetes", "mellitus", "or", "maternal", "PKU", "can", "complicate", "the", "maternal", "situation", ".", "Optimal", "nutrition", "during", "pregnancy", "includes", "at", "least", "in", "the", "2nd", "or", "3rd", "trimester", "increased", "energy", "supply", "(", "+300", "kcal", "/", "day", ")", "and", "an", "increase", "in", "all", "nutrients", ",", "including", "minerals", "and", "vitamins", ".", "Of", "special", "importance", "are", "-3-fatty", "acids", ",", "iron", ",", "magnesium", ",", "zinc", ",", "iodine", ",", "and", "folic", "acid", ",", "vita", "-", "min", "B12", "and", "vitamin", "K.", "Under-", "and", "overnu", "-", "trition", "and", "deficiencies", "in", "the", "above", "nutrients", "may", "have", "an", "influence", "on", "the", "outcome", "of", "pregnancy", "and", "the", "health", "of", "the", "baby", ":", "more", "spontaneous", "abortions", ",", "prematurity", ",", "low", "birth", "weight", ",", "birth", "defects", ",", "intra-", "and", "extrauterine", "developmental", "disturbances", "and", "organ", "dysfunctions", "." ]	[ "umlsterm" ]
Maternal nutrition, pregnancy, lactation, preventive, health, child, nutritional status, mother, nutrition, weight gain, Diseases, mother, diet, diabetes mellitus, maternal PKU, nutrition, pregnancy, 3rd trimester, energy supply, minerals, vitamins, acids, iron, magnesium, zinc, iodine, folic acid, vitamin, deficiencies, pregnancy, health, baby, spontaneous abortions, prematurity, low birth weight, birth defects, dysfunctions	MonatsschriftKinderheilkunde.8146s073.eng.abstr_task2	Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .	[ "Maternal", "nutrition", "during", "pregnancy", "and", "lactation", "has", "great", "preventive", "importance", "for", "the", "health", "of", "the", "young", "child", ".", "Important", "determinants", "are", "the", "pregravid", "nutritional", "status", "of", "the", "mother", ",", "the", "quantity", "and", "quality", "of", "the", "nutrition", "and", "gestational", "weight", "gain", ".", "Diseases", "of", "the", "mother", "that", "have", "to", "be", "treated", "by", "a", "special", "diet", "like", "diabetes", "mellitus", "or", "maternal", "PKU", "can", "complicate", "the", "maternal", "situation", ".", "Optimal", "nutrition", "during", "pregnancy", "includes", "at", "least", "in", "the", "2nd", "or", "3rd", "trimester", "increased", "energy", "supply", "(", "+300", "kcal", "/", "day", ")", "and", "an", "increase", "in", "all", "nutrients", ",", "including", "minerals", "and", "vitamins", ".", "Of", "special", "importance", "are", "-3-fatty", "acids", ",", "iron", ",", "magnesium", ",", "zinc", ",", "iodine", ",", "and", "folic", "acid", ",", "vita", "-", "min", "B12", "and", "vitamin", "K.", "Under-", "and", "overnu", "-", "trition", "and", "deficiencies", "in", "the", "above", "nutrients", "may", "have", "an", "influence", "on", "the", "outcome", "of", "pregnancy", "and", "the", "health", "of", "the", "baby", ":", "more", "spontaneous", "abortions", ",", "prematurity", ",", "low", "birth", "weight", ",", "birth", "defects", ",", "intra-", "and", "extrauterine", "developmental", "disturbances", "and", "organ", "dysfunctions", "." ]	[ "umlsterm" ]
Stroke is an umlsterm, Prevention is an umlsterm, Ischaemia is an umlsterm, randomised clinical trial is an umlsterm, patients is an umlsterm, cerebral ischaemia is an umlsterm, origin is an umlsterm, anticoagulation is an umlsterm, international normalized ratio is an umlsterm, INR is an umlsterm, acetylsalicylic acid is an umlsterm, dipyridamole is an umlsterm, acetylsalicylic acid is an umlsterm, patients is an umlsterm, death is an umlsterm, stroke is an umlsterm, myocardial infarction is an umlsterm, complication is an umlsterm, outcome assessment is an umlsterm, multicentre study is an umlsterm, hospitals is an umlsterm, Netherlands is an umlsterm, Europe is an umlsterm, Australia is an umlsterm	DerNervenarzt.90700368.eng.abstr_task0	Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .	[ "The", "European", "and", "Australian", "Stroke", "Prevention", "in", "Reversible", "Ischaemia", "Trial", "(", "ESPRIT", ")", "is", "a", "randomised", "clinical", "trial", "in", "which", "patients", "with", "cerebral", "ischaemia", "of", "arterial", "origin", "will", "be", "randomised", "between", "oral", "anticoagulation", "(", "international", "normalized", "ratio", "(", "INR", ")", ":", "2.0", "-", "3.0", ")", ",", "the", "combination", "of", "acetylsalicylic", "acid", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", "plus", "dipyridamole", "(", "400", "mg", "daily", ")", "and", "acetylsalicylic", "acid", "only", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", ".", "It", "is", "planned", "to", "enroll", "4500", "patients", "with", "a", "mean", "follow", "-", "up", "of", "three", "years", ".", "Primary", "outcome", "is", "the", "composite", "event", "of", "vascular", "death", ",", "stroke", ",", "myocardial", "infarction", ",", "or", "major", "bleeding", "complication", ";", "outcome", "assessment", "will", "be", "blinded", ".", "ESPRIT", "is", "an", "international", ",", "multicentre", "study", "in", "which", "60", "-", "80", "hospitals", "in", "the", "Netherlands", "and", "other", "countries", "in", "Europe", "and", "Australia", "will", "participate", "." ]	[ "umlsterm" ]
Stroke is an umlsterm, Prevention is an umlsterm, Ischaemia is an umlsterm, randomised clinical trial is an umlsterm, patients is an umlsterm, cerebral ischaemia is an umlsterm, origin is an umlsterm, anticoagulation is an umlsterm, international normalized ratio is an umlsterm, INR is an umlsterm, acetylsalicylic acid is an umlsterm, dipyridamole is an umlsterm, acetylsalicylic acid is an umlsterm, patients is an umlsterm, death is an umlsterm, stroke is an umlsterm, myocardial infarction is an umlsterm, complication is an umlsterm, outcome assessment is an umlsterm, multicentre study is an umlsterm, hospitals is an umlsterm, Netherlands is an umlsterm, Europe is an umlsterm, Australia is an umlsterm	DerNervenarzt.90700368.eng.abstr_task1	Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please typing these entity words according to sentence: Stroke, Prevention, Ischaemia, randomised clinical trial, patients, cerebral ischaemia, origin, anticoagulation, international normalized ratio, INR, acetylsalicylic acid, dipyridamole, acetylsalicylic acid, patients, death, stroke, myocardial infarction, complication, outcome assessment, multicentre study, hospitals, Netherlands, Europe, Australia Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .	[ "The", "European", "and", "Australian", "Stroke", "Prevention", "in", "Reversible", "Ischaemia", "Trial", "(", "ESPRIT", ")", "is", "a", "randomised", "clinical", "trial", "in", "which", "patients", "with", "cerebral", "ischaemia", "of", "arterial", "origin", "will", "be", "randomised", "between", "oral", "anticoagulation", "(", "international", "normalized", "ratio", "(", "INR", ")", ":", "2.0", "-", "3.0", ")", ",", "the", "combination", "of", "acetylsalicylic", "acid", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", "plus", "dipyridamole", "(", "400", "mg", "daily", ")", "and", "acetylsalicylic", "acid", "only", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", ".", "It", "is", "planned", "to", "enroll", "4500", "patients", "with", "a", "mean", "follow", "-", "up", "of", "three", "years", ".", "Primary", "outcome", "is", "the", "composite", "event", "of", "vascular", "death", ",", "stroke", ",", "myocardial", "infarction", ",", "or", "major", "bleeding", "complication", ";", "outcome", "assessment", "will", "be", "blinded", ".", "ESPRIT", "is", "an", "international", ",", "multicentre", "study", "in", "which", "60", "-", "80", "hospitals", "in", "the", "Netherlands", "and", "other", "countries", "in", "Europe", "and", "Australia", "will", "participate", "." ]	[ "umlsterm" ]
Stroke, Prevention, Ischaemia, randomised clinical trial, patients, cerebral ischaemia, origin, anticoagulation, international normalized ratio, INR, acetylsalicylic acid, dipyridamole, acetylsalicylic acid, patients, death, stroke, myocardial infarction, complication, outcome assessment, multicentre study, hospitals, Netherlands, Europe, Australia	DerNervenarzt.90700368.eng.abstr_task2	Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O" ]	The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .	[ "The", "European", "and", "Australian", "Stroke", "Prevention", "in", "Reversible", "Ischaemia", "Trial", "(", "ESPRIT", ")", "is", "a", "randomised", "clinical", "trial", "in", "which", "patients", "with", "cerebral", "ischaemia", "of", "arterial", "origin", "will", "be", "randomised", "between", "oral", "anticoagulation", "(", "international", "normalized", "ratio", "(", "INR", ")", ":", "2.0", "-", "3.0", ")", ",", "the", "combination", "of", "acetylsalicylic", "acid", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", "plus", "dipyridamole", "(", "400", "mg", "daily", ")", "and", "acetylsalicylic", "acid", "only", "(", "in", "any", "dose", "between", "30", "and", "325", "mg", "per", "day", ")", ".", "It", "is", "planned", "to", "enroll", "4500", "patients", "with", "a", "mean", "follow", "-", "up", "of", "three", "years", ".", "Primary", "outcome", "is", "the", "composite", "event", "of", "vascular", "death", ",", "stroke", ",", "myocardial", "infarction", ",", "or", "major", "bleeding", "complication", ";", "outcome", "assessment", "will", "be", "blinded", ".", "ESPRIT", "is", "an", "international", ",", "multicentre", "study", "in", "which", "60", "-", "80", "hospitals", "in", "the", "Netherlands", "and", "other", "countries", "in", "Europe", "and", "Australia", "will", "participate", "." ]	[ "umlsterm" ]

noninvasive haemoglobin measurement, pulse oximetry, oximetry haemoglobin, infusion experiments

57863_task2

Sentence: Accuracy of noninvasive haemoglobin measurement by pulse oximetry depends on the type of infusion fluid . CONTEXT Measurement of blood haemoglobin concentration by pulse oximetry could be of value in determining when erythrocytes should be transfused during surgery , but the effect of infusion fluids on the results is unclear . OBJECTIVE To study the effect of crystalloid and colloid fluid on the accuracy ( bias ) and precision of pulse oximetry haemoglobin estimation to indicate the venous haemoglobin concentration in volunteers . DESIGN Open interventional crossover study . SETTING Single university hospital . PARTICIPANTS Ten male volunteers aged 18-28 ( mean 22 ) years . INTERVENTIONS Each volunteer underwent three infusion experiments on separate days and in random order . The infusions were Ringer 's acetate ( 20 ml kg ) , hydroxyethyl starch 130/0.4 ( 10 ml kg ) and a combination of both . RESULTS At the end of the infusions of Ringer 's acetate , pulse oximetry haemoglobin concentration had decreased more than the true haemoglobin concentration ( 15 vs. 8 % ; P < 0.005 ; n = 10 ) whereas starch solution decreased pulse oximetry haemoglobin concentration less than true haemoglobin concentration ( 7 vs. 11 % ; P < 0.02 ; n = 20 ) . The same differences were seen when the fluids were infused separately and when they were combined . The overall difference between all 956 pairs of pulse oximetry haemoglobin concentration and true haemoglobin concentrations ( the bias ) averaged only -0.7 g l whereas the 95 % prediction interval was wide , ranging from -24.9 to 23.7 g l. In addition to the choice of infusion fluid , the bias was strongly dependent on the volunteer ( each factor , P < 0.001 ) . CONCLUSION The bias of measuring haemoglobin concentration by pulse oximetry is dependent on whether a crystalloid or a colloid fluid is infused . TRIAL REGISTRATION ClinicalTrials identifier : NCT01195025 . Instructions: please extract entity words from the input sentence

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Accuracy of noninvasive haemoglobin measurement by pulse oximetry depends on the type of infusion fluid . CONTEXT Measurement of blood haemoglobin concentration by pulse oximetry could be of value in determining when erythrocytes should be transfused during surgery , but the effect of infusion fluids on the results is unclear . OBJECTIVE To study the effect of crystalloid and colloid fluid on the accuracy ( bias ) and precision of pulse oximetry haemoglobin estimation to indicate the venous haemoglobin concentration in volunteers . DESIGN Open interventional crossover study . SETTING Single university hospital . PARTICIPANTS Ten male volunteers aged 18-28 ( mean 22 ) years . INTERVENTIONS Each volunteer underwent three infusion experiments on separate days and in random order . The infusions were Ringer 's acetate ( 20 ml kg ) , hydroxyethyl starch 130/0.4 ( 10 ml kg ) and a combination of both . RESULTS At the end of the infusions of Ringer 's acetate , pulse oximetry haemoglobin concentration had decreased more than the true haemoglobin concentration ( 15 vs. 8 % ; P < 0.005 ; n = 10 ) whereas starch solution decreased pulse oximetry haemoglobin concentration less than true haemoglobin concentration ( 7 vs. 11 % ; P < 0.02 ; n = 20 ) . The same differences were seen when the fluids were infused separately and when they were combined . The overall difference between all 956 pairs of pulse oximetry haemoglobin concentration and true haemoglobin concentrations ( the bias ) averaged only -0.7 g l whereas the 95 % prediction interval was wide , ranging from -24.9 to 23.7 g l. In addition to the choice of infusion fluid , the bias was strongly dependent on the volunteer ( each factor , P < 0.001 ) . CONCLUSION The bias of measuring haemoglobin concentration by pulse oximetry is dependent on whether a crystalloid or a colloid fluid is infused . TRIAL REGISTRATION ClinicalTrials identifier : NCT01195025 .

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[ "Outcome_Other", "Intervention_Physical", "Outcome_Physical" ]

verprolin is a Gene/protein/RNA, cofilin is a Gene/protein/RNA, actin is a Gene/protein/RNA

280_task0

Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]

First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.

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[ "Gene/protein/RNA" ]

verprolin is a Gene/protein/RNA, cofilin is a Gene/protein/RNA, actin is a Gene/protein/RNA

280_task1

Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please typing these entity words according to sentence: verprolin, cofilin, actin Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]

First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.

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[ "Gene/protein/RNA" ]

verprolin, cofilin, actin

280_task2

Sentence: First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "O", "O" ]

First, the C-terminal verprolin-cofilin-acidic domain was shown to be essential for the regulation of actin cytoskeleton.

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[ "Gene/protein/RNA" ]

interleukin 2 is a Protein, Ca2+/calmodulin kinase type IV / Gr is a Protein, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr is a Protein, CaMKIV / Gr is a Protein, p21ras is a Protein, CaMKIV/ Gr is a Protein, c - fos is a Protein, p21ras is a Protein, interleukin 2 is a Protein, CaMKIV / Gr is a Protein, CaMKIV / Gr is a Protein

601_task0

Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.

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[ "Protein" ]

interleukin 2 is a Protein, Ca2+/calmodulin kinase type IV / Gr is a Protein, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr is a Protein, CaMKIV / Gr is a Protein, p21ras is a Protein, CaMKIV/ Gr is a Protein, c - fos is a Protein, p21ras is a Protein, interleukin 2 is a Protein, CaMKIV / Gr is a Protein, CaMKIV / Gr is a Protein

601_task1

Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please typing these entity words according to sentence: interleukin 2, Ca2+/calmodulin kinase type IV / Gr, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr, CaMKIV / Gr, p21ras, CaMKIV/ Gr, c - fos, p21ras, interleukin 2, CaMKIV / Gr, CaMKIV / Gr Options: Protein

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Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.

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[ "Protein" ]

interleukin 2, Ca2+/calmodulin kinase type IV / Gr, Ca2+/calmodulin - dependent protein kinase ( CaMK ) type IV / Gr, CaMKIV / Gr, p21ras, CaMKIV/ Gr, c - fos, p21ras, interleukin 2, CaMKIV / Gr, CaMKIV / Gr

601_task2

Sentence: Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes. Instructions: please extract entity words from the input sentence

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Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.

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[ "Protein" ]

Arg389Gly is a GENE-N, beta1-adrenoceptor is a GENE-Y, catecholamine is a CHEMICAL, renin is a GENE-Y

16325050_task0

Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.

[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

Arg389Gly is a GENE-N, beta1-adrenoceptor is a GENE-Y, catecholamine is a CHEMICAL, renin is a GENE-Y

16325050_task1

Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please typing these entity words according to sentence: Arg389Gly, beta1-adrenoceptor, catecholamine, renin Options: GENE-Y, GENE-N, CHEMICAL

[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.

[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

Arg389Gly, beta1-adrenoceptor, catecholamine, renin

16325050_task2

Sentence: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. Instructions: please extract entity words from the input sentence

[ "O", "B-GENE-N", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.

[ "The", "Arg389Gly", "beta1-adrenoceptor", "polymorphism", "and", "catecholamine", "effects", "on", "plasma", "-", "renin", "activity", "." ]

[ "GENE-Y", "CHEMICAL", "GENE-N" ]

mdm2 is a protein, p53 is a protein, p53 is a protein, ubiquitin is a protein-family

1.0alpha7.train.840_task0

Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein

[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).

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[ "protein-family", "protein" ]

mdm2 is a protein, p53 is a protein, p53 is a protein, ubiquitin is a protein-family

1.0alpha7.train.840_task1

Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please typing these entity words according to sentence: mdm2, p53, p53, ubiquitin Options: protein-family, protein

[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).

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[ "protein-family", "protein" ]

mdm2, p53, p53, ubiquitin

1.0alpha7.train.840_task2

Sentence: Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Binding of mdm2 to p53 also targets p53 for degradation through ubiquitin-mediated pathways ( 19, 20).

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[ "protein-family", "protein" ]

hyaluronic acid is a Intervention_Pharmacological, triamcinolone hexacetonide is a Intervention_Pharmacological, inflammatory knee osteoarthritis is a Participant_Condition, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ) is a Intervention_Pharmacological, 63 patients is a Participant_Sample-size, 24 male is a Participant_Sex, 39 female is a Participant_Sex, age 70.5 years is a Participant_Age, bilateral symptomatic knee osteoarthritis with effusion is a Participant_Condition, HA injections is a Intervention_Pharmacological, 20 mg is a Intervention_Control, placebo ( saline ) injections is a Intervention_Control, visual analog scores ( VAS ) for pain is a Outcome_Pain, duration of stiffness is a Outcome_Physical, range of movement is a Outcome_Physical, joint effusion is a Outcome_Physical, local heat is a Outcome_Physical, synovial thickening is a Outcome_Physical, joint - line and periarticular tenderness is a Outcome_Physical, pain on a self - selected activity assessed by Vas is a Outcome_Pain

87292_task0

Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Pain, Outcome_Physical, Participant_Sample-size

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Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]

hyaluronic acid is a Intervention_Pharmacological, triamcinolone hexacetonide is a Intervention_Pharmacological, inflammatory knee osteoarthritis is a Participant_Condition, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ) is a Intervention_Pharmacological, 63 patients is a Participant_Sample-size, 24 male is a Participant_Sex, 39 female is a Participant_Sex, age 70.5 years is a Participant_Age, bilateral symptomatic knee osteoarthritis with effusion is a Participant_Condition, HA injections is a Intervention_Pharmacological, 20 mg is a Intervention_Control, placebo ( saline ) injections is a Intervention_Control, visual analog scores ( VAS ) for pain is a Outcome_Pain, duration of stiffness is a Outcome_Physical, range of movement is a Outcome_Physical, joint effusion is a Outcome_Physical, local heat is a Outcome_Physical, synovial thickening is a Outcome_Physical, joint - line and periarticular tenderness is a Outcome_Physical, pain on a self - selected activity assessed by Vas is a Outcome_Pain

87292_task1

Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please typing these entity words according to sentence: hyaluronic acid, triamcinolone hexacetonide, inflammatory knee osteoarthritis, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ), 63 patients, 24 male, 39 female, age 70.5 years, bilateral symptomatic knee osteoarthritis with effusion, HA injections, 20 mg, placebo ( saline ) injections, visual analog scores ( VAS ) for pain, duration of stiffness, range of movement, joint effusion, local heat, synovial thickening, joint - line and periarticular tenderness, pain on a self - selected activity assessed by Vas Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Pain, Outcome_Physical, Participant_Sample-size

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Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]

hyaluronic acid, triamcinolone hexacetonide, inflammatory knee osteoarthritis, intra - articular ( i / a ) triamcinolone . hexacetonide ( TH ) and i / a hyaluronic acid ( HA ), 63 patients, 24 male, 39 female, age 70.5 years, bilateral symptomatic knee osteoarthritis with effusion, HA injections, 20 mg, placebo ( saline ) injections, visual analog scores ( VAS ) for pain, duration of stiffness, range of movement, joint effusion, local heat, synovial thickening, joint - line and periarticular tenderness, pain on a self - selected activity assessed by Vas

87292_task2

Sentence: Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action . Instructions: please extract entity words from the input sentence

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Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Pain", "Outcome_Physical", "Intervention_Control", "Participant_Age", "Participant_Sample-size", "Participant_Sex" ]

surgery is an umlsterm, patients is an umlsterm, plan is an umlsterm, reintubation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, carcinoma is an umlsterm, hypopharynx is an umlsterm, risk is an umlsterm, intubation is an umlsterm, general anaesthesia is an umlsterm, patients is an umlsterm, acute abdomen is an umlsterm, ileus is an umlsterm, trachea is an umlsterm, fiberoptic is an umlsterm, reintubation is an umlsterm

DerAnaesthesist.40430618.eng.abstr_task0

Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .

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[ "umlsterm" ]

surgery is an umlsterm, patients is an umlsterm, plan is an umlsterm, reintubation is an umlsterm, patients is an umlsterm, thyroid is an umlsterm, carcinoma is an umlsterm, carcinoma is an umlsterm, hypopharynx is an umlsterm, risk is an umlsterm, intubation is an umlsterm, general anaesthesia is an umlsterm, patients is an umlsterm, acute abdomen is an umlsterm, ileus is an umlsterm, trachea is an umlsterm, fiberoptic is an umlsterm, reintubation is an umlsterm

DerAnaesthesist.40430618.eng.abstr_task1

Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please typing these entity words according to sentence: surgery, patients, plan, reintubation, patients, thyroid, carcinoma, carcinoma, hypopharynx, risk, intubation, general anaesthesia, patients, acute abdomen, ileus, trachea, fiberoptic, reintubation Options: umlsterm

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Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .

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[ "umlsterm" ]

surgery, patients, plan, reintubation, patients, thyroid, carcinoma, carcinoma, hypopharynx, risk, intubation, general anaesthesia, patients, acute abdomen, ileus, trachea, fiberoptic, reintubation

DerAnaesthesist.40430618.eng.abstr_task2

Sentence: Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation . Instructions: please extract entity words from the input sentence

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Securing the airway following surgery can be a problem in certain patients . Preparation , therefore , should include a plan for safe reintubation , if necessary . We report two patients with a difficult airway ( recurrent thyroid carcinoma , inoperable carcinoma of the hypopharynx ) who were at a high risk for intubation under general anaesthesia . In addition , one of the patients suffered from an acute abdomen and ileus . We used a guidewire placed into the trachea via a fiberscope to facilitate fiberoptic reintubation .

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[ "umlsterm" ]

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DerOrthopaede.00290327.eng.abstr_task0

Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .

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[ "umlsterm" ]

contrast is an umlsterm, humeral fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, injury is an umlsterm, old is an umlsterm, patient is an umlsterm, fracture is an umlsterm, osteoporosis is an umlsterm, multi - morbidity is an umlsterm, classification is an umlsterm, head is an umlsterm, fractures is an umlsterm, fractures is an umlsterm, head is an umlsterm, fractures is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, surgical procedures is an umlsterm, head is an umlsterm, treatment is an umlsterm, choice is an umlsterm, patients is an umlsterm, morbidity is an umlsterm, treatment is an umlsterm, fractures is an umlsterm, humerus is an umlsterm, fractures is an umlsterm, recommendations is an umlsterm, elderly is an umlsterm, open is an umlsterm, postoperative is an umlsterm, treatment is an umlsterm, tissue is an umlsterm, injuries is an umlsterm, patients is an umlsterm, surgical is an umlsterm, proximal humeral fractures is an umlsterm, surgical treatment is an umlsterm

DerOrthopaede.00290327.eng.abstr_task1

Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please typing these entity words according to sentence: contrast, humeral fractures, head, fractures, injury, old, patient, fracture, osteoporosis, multi - morbidity, classification, head, fractures, fractures, head, fractures, treatment, fractures, humerus, surgical procedures, head, treatment, choice, patients, morbidity, treatment, fractures, humerus, fractures, recommendations, elderly, open, postoperative, treatment, tissue, injuries, patients, surgical, proximal humeral fractures, surgical treatment Options: umlsterm

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In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .

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[ "umlsterm" ]

contrast, humeral fractures, head, fractures, injury, old, patient, fracture, osteoporosis, multi - morbidity, classification, head, fractures, fractures, head, fractures, treatment, fractures, humerus, surgical procedures, head, treatment, choice, patients, morbidity, treatment, fractures, humerus, fractures, recommendations, elderly, open, postoperative, treatment, tissue, injuries, patients, surgical, proximal humeral fractures, surgical treatment

DerOrthopaede.00290327.eng.abstr_task2

Sentence: In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment . Instructions: please extract entity words from the input sentence

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In contrast to distal humeral fractures , humeral head fractures represent a common injury to the old patient . For both fracture localizations osteoporosis and multi-morbidity are of significant importance . The classification for humeral head fractures in one- , two- , three- and four-part fractures is generally accepted . Valgus impacted head fractures as well as head-splitting fractures are considered a seperate entity . In none or minimally displaced fractures good functional results are achieved by conservative means . Although numerous therapeutical procdure are offered in the treatment of displaced fractures of the proximal humerus the result are often disappointing . Generally , minimal invasive surgical procedures should be preferred . However , in dislocated multi-part fractures a primary humeral head replacement is often the treatment of choice . In patients with mutifarious morbidity a conservative treatment is always to be included into the therapeutical considerations . Distal fractures of the humerus are classified into extraarticular , intraarticular unicondylar and intraarticular bicondylar fractures . The therapeutical recommendations , also in the elderly , is relatively homogenous : primary open reduction and internal fixation ( ORIF ) should be carried out aiming for an early postoperative functional treatment . Depending from soft tissue conditions and accompanying injuries the functional results are often good or moderate and are generally comparable to those of younger patients . Following a correct indication for surgical intervention the main priority for both distal and proximal humeral fractures is an early definitive surgical treatment .

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[ "umlsterm" ]

prospective study is an umlsterm, microcatheter is an umlsterm, spinal anaesthesia is an umlsterm, technique is an umlsterm, trauma is an umlsterm, patients is an umlsterm

DerAnaesthesist.70460938.eng.abstr_task0

Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .

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[ "umlsterm" ]

prospective study is an umlsterm, microcatheter is an umlsterm, spinal anaesthesia is an umlsterm, technique is an umlsterm, trauma is an umlsterm, patients is an umlsterm

DerAnaesthesist.70460938.eng.abstr_task1

Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please typing these entity words according to sentence: prospective study, microcatheter, spinal anaesthesia, technique, trauma, patients Options: umlsterm

[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .

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[ "umlsterm" ]

prospective study, microcatheter, spinal anaesthesia, technique, trauma, patients

DerAnaesthesist.70460938.eng.abstr_task2

Sentence: In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

In this prospective study we investigated the efficacy of microcatheter spinal anaesthesia in comparison with a combined spinal-epidural technique in trauma patients .

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[ "umlsterm" ]

[ Metastatic breast cancer is a Participant_Condition, tamoxifen is a Intervention_Pharmacological, medroxyprogesterone acetate is a Intervention_Pharmacological, Seventy - nine is a Participant_Sample-size, histologically proven disseminated breast cancer is a Participant_Condition, never treated before with additive hormonal therapy is a Participant_Condition, tamoxifen ( TAM ) is a Intervention_Pharmacological, mean is a Outcome_Physical, duration of therapeutic response is a Outcome_Other

78518_task0

Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other

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[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]

[ Metastatic breast cancer is a Participant_Condition, tamoxifen is a Intervention_Pharmacological, medroxyprogesterone acetate is a Intervention_Pharmacological, Seventy - nine is a Participant_Sample-size, histologically proven disseminated breast cancer is a Participant_Condition, never treated before with additive hormonal therapy is a Participant_Condition, tamoxifen ( TAM ) is a Intervention_Pharmacological, mean is a Outcome_Physical, duration of therapeutic response is a Outcome_Other

78518_task1

Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please typing these entity words according to sentence: [ Metastatic breast cancer, tamoxifen, medroxyprogesterone acetate, Seventy - nine, histologically proven disseminated breast cancer, never treated before with additive hormonal therapy, tamoxifen ( TAM ), mean, duration of therapeutic response Options: Intervention_Pharmacological, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other

[ "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]

[ Metastatic breast cancer, tamoxifen, medroxyprogesterone acetate, Seventy - nine, histologically proven disseminated breast cancer, never treated before with additive hormonal therapy, tamoxifen ( TAM ), mean, duration of therapeutic response

78518_task2

Sentence: [ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) . Instructions: please extract entity words from the input sentence

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[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .

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[ "Participant_Condition", "Outcome_Other", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Sample-size" ]

beta - like globin is a Protein, chloramphenicol acetyltransferase is a Protein, CAT is a Protein, CAT is a Protein, CAT is a Protein

245_task0

Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.

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[ "Protein" ]

beta - like globin is a Protein, chloramphenicol acetyltransferase is a Protein, CAT is a Protein, CAT is a Protein, CAT is a Protein

245_task1

Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please typing these entity words according to sentence: beta - like globin, chloramphenicol acetyltransferase, CAT, CAT, CAT Options: Protein

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Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.

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[ "Protein" ]

beta - like globin, chloramphenicol acetyltransferase, CAT, CAT, CAT

245_task2

Sentence: Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Instructions: please extract entity words from the input sentence

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Transcription of the hypersensitive site HS2 enhancer in erythroid cells. In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away. The mechanism of HS2 enhancer function is not known. The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene. In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable. Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene. In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.

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[ "Protein" ]

NuA4 is a Complex, transcription adaptor is a Gene_or_gene_product, histone H4 acetyltransferase is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, ATM is a Gene_or_gene_product, Tra1p is a Gene_or_gene_product, histone H4 is a Gene_or_gene_product, chromatin is a Cellular_component, nuclear is a Cellular_component, NuA4 is a Complex, nucleosomal is a Cellular_component, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, lysines is a Simple_chemical, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, ESA1 is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, NuA4 is a Complex, esa1 is a Gene_or_gene_product, TRA1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, TRRAP is a Gene_or_gene_product, E2F is a Gene_or_gene_product, NuA4 is a Complex, chromatin is a Cellular_component, esa1 is a Gene_or_gene_product, Esa1 is a Gene_or_gene_product, HAT is a Gene_or_gene_product, NuA4 is a Complex, Tra1p is a Gene_or_gene_product, nuclear is a Cellular_component, H4 is a Gene_or_gene_product

13_task0

Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component

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NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.

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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical", "Complex" ]

NuA4 is a Complex, transcription adaptor is a Gene_or_gene_product, histone H4 acetyltransferase is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, ATM is a Gene_or_gene_product, Tra1p is a Gene_or_gene_product, histone H4 is a Gene_or_gene_product, chromatin is a Cellular_component, nuclear is a Cellular_component, NuA4 is a Complex, nucleosomal is a Cellular_component, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, lysines is a Simple_chemical, histone H4 is a Gene_or_gene_product, NuA4 is a Complex, ESA1 is a Gene_or_gene_product, Esa1p is a Gene_or_gene_product, NuA4 is a Complex, esa1 is a Gene_or_gene_product, TRA1 is a Gene_or_gene_product, ATM is a Gene_or_gene_product, TRRAP is a Gene_or_gene_product, E2F is a Gene_or_gene_product, NuA4 is a Complex, chromatin is a Cellular_component, esa1 is a Gene_or_gene_product, Esa1 is a Gene_or_gene_product, HAT is a Gene_or_gene_product, NuA4 is a Complex, Tra1p is a Gene_or_gene_product, nuclear is a Cellular_component, H4 is a Gene_or_gene_product

13_task1

Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please typing these entity words according to sentence: NuA4, transcription adaptor, histone H4 acetyltransferase, Esa1p, ATM, Tra1p, histone H4, chromatin, nuclear, NuA4, nucleosomal, histone H4, NuA4, lysines, histone H4, NuA4, ESA1, Esa1p, NuA4, esa1, TRA1, ATM, TRRAP, E2F, NuA4, chromatin, esa1, Esa1, HAT, NuA4, Tra1p, nuclear, H4 Options: Simple_chemical, Complex, Gene_or_gene_product, Cellular_component

[ "B-Complex", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Simple_chemical", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.

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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical", "Complex" ]

NuA4, transcription adaptor, histone H4 acetyltransferase, Esa1p, ATM, Tra1p, histone H4, chromatin, nuclear, NuA4, nucleosomal, histone H4, NuA4, lysines, histone H4, NuA4, ESA1, Esa1p, NuA4, esa1, TRA1, ATM, TRRAP, E2F, NuA4, chromatin, esa1, Esa1, HAT, NuA4, Tra1p, nuclear, H4

13_task2

Sentence: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. Instructions: please extract entity words from the input sentence

[ "B-Complex", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Simple_chemical", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Complex", "O", "O", "O", "O", "O", "B-Cellular_component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Complex", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. Post-translational acetylation of histone H4 N-terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an apparent molecular mass of 1.3 MDa. All four conserved lysines of histone H4 can be acetylated by NuA4. We have identified the catalytic subunit of the complex as the product of ESA1, an essential gene required for cell cycle progression in yeast. Antibodies against Esa1p specifically immunoprecipitate NuA4 activity whereas the complex purified from a temperature-sensitive esa1 mutant loses its acetyltransferase activity at the restrictive temperature. Additionally, we have identified another subunit of the complex as the product of TRA1, an ATM-related essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4-VP16-driven transcription from chromatin templates in vitro is also lost in the temperature-sensitive esa1 mutant. The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative transcription activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control.

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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical", "Complex" ]

Objective is an umlsterm, Pemphigoid is an umlsterm, pregnancy - associated is an umlsterm, disease is an umlsterm, autoantibodies is an umlsterm, bullous pemphigoid antigen is an umlsterm, diagnostic is an umlsterm, skin is an umlsterm, biopsy is an umlsterm, autoantibodies is an umlsterm

DerHautarzt.00510025.eng.abstr_task0

Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .

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[ "umlsterm" ]

Objective is an umlsterm, Pemphigoid is an umlsterm, pregnancy - associated is an umlsterm, disease is an umlsterm, autoantibodies is an umlsterm, bullous pemphigoid antigen is an umlsterm, diagnostic is an umlsterm, skin is an umlsterm, biopsy is an umlsterm, autoantibodies is an umlsterm

DerHautarzt.00510025.eng.abstr_task1

Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please typing these entity words according to sentence: Objective, Pemphigoid, pregnancy - associated, disease, autoantibodies, bullous pemphigoid antigen, diagnostic, skin, biopsy, autoantibodies Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .

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[ "umlsterm" ]

Objective, Pemphigoid, pregnancy - associated, disease, autoantibodies, bullous pemphigoid antigen, diagnostic, skin, biopsy, autoantibodies

DerHautarzt.00510025.eng.abstr_task2

Sentence: Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies .

[ "Background", "and", "Objective", ":", "Pemphigoid", "gestationis", "(", "PG", ")", "is", "a", "rare", "pregnancy", "-", "associated", "autoimmune", "bullous", "disease", "characterized", "by", "autoantibodies", "to", "the", "180", "kD", "bullous", "pemphigoid", "antigen", "(", "BP180", ")", ".", "The", "clinical", "spectrum", "of", "PG", "is", "polymorphic", "and", "for", "diagnostic", "purposes", ",", "a", "skin", "biopsy", "is", "usually", "taken", "demonstrating", "the", "deposition", "of", "autoantibodies", "." ]

[ "umlsterm" ]

Roentgenaufnahmen is an umlsterm, Thorax is an umlsterm, Intensivtherapie is an umlsterm

DerRadiologe.80380730.ger.abstr_task0

Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .

[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]

[ "umlsterm" ]

Roentgenaufnahmen is an umlsterm, Thorax is an umlsterm, Intensivtherapie is an umlsterm

DerRadiologe.80380730.ger.abstr_task1

Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please typing these entity words according to sentence: Roentgenaufnahmen, Thorax, Intensivtherapie Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .

[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]

[ "umlsterm" ]

Roentgenaufnahmen, Thorax, Intensivtherapie

DerRadiologe.80380730.ger.abstr_task2

Sentence: Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie . Instructions: please extract entity words from the input sentence

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Ziel : Abschaetzung des zusaetzlichen individuellen Krebsrisikos gemaess ICRP 60 bei mehrfachen Roentgenaufnahmen des Thorax a.p. liegend bei langdauernder Intensivtherapie .

[ "Ziel", ":", "Abschaetzung", "des", "zusaetzlichen", "individuellen", "Krebsrisikos", "gemaess", "ICRP", "60", "bei", "mehrfachen", "Roentgenaufnahmen", "des", "Thorax", "a.p", ".", "liegend", "bei", "langdauernder", "Intensivtherapie", "." ]

[ "umlsterm" ]

amoxicilina - clavulánico is a NORMALIZABLES, amoxicilina - clavulánico is a NORMALIZABLES, proteína C reactiva is a PROTEINAS, PCR is a PROTEINAS, α - amilasa is a PROTEINAS, amoxicilina - clavulánico is a NORMALIZABLES

456_task0

Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS

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Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.

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[ "NORMALIZABLES", "PROTEINAS" ]

amoxicilina - clavulánico is a NORMALIZABLES, amoxicilina - clavulánico is a NORMALIZABLES, proteína C reactiva is a PROTEINAS, PCR is a PROTEINAS, α - amilasa is a PROTEINAS, amoxicilina - clavulánico is a NORMALIZABLES

456_task1

Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please typing these entity words according to sentence: amoxicilina - clavulánico, amoxicilina - clavulánico, proteína C reactiva, PCR, α - amilasa, amoxicilina - clavulánico Options: NORMALIZABLES, PROTEINAS

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Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.

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[ "NORMALIZABLES", "PROTEINAS" ]

amoxicilina - clavulánico, amoxicilina - clavulánico, proteína C reactiva, PCR, α - amilasa, amoxicilina - clavulánico

456_task2

Sentence: Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año. Instructions: please extract entity words from the input sentence

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Niño previamente sano. Como únicos antecedentes, fue operado de criptorquidia izquierda; está vacunado correctamente para su edad. Con cinco años presenta por primera vez inflamación parotídea bilateral (con eritema, hinchazón y dolor), acompañada de fiebre que fue manejado de forma ambulatoria con amoxicilina-clavulánico y antiinflamatorios por vía oral. Tuvo un segundo episodio, también manejado de forma ambulatoria. El tercer episodio precisó ingreso hospitalario por mala evolución clínica y afectación del estado general tras el inicio de tratamiento con amoxicilina-clavulánico por vía oral. En la exploración física destacaba una tumoración laterocervical bilateral (inicialmente derecha) que borraba el ángulo mandibular, sin signos de fluctuación ni secreción o signos inflamatorios de conducto de Stenon. Se realizó una analítica sanguínea, que mostró una importante leucocitosis (24 100/mm3) con neutrofilia (78,7%), proteína C reactiva (PCR) de 4,11 mg/dl y elevación de la α-amilasa (hasta 1451 U/l). Durante el ingreso se realizó una ecografía que mostró un aumento del tamaño de las parótidas, con aumento de densidad, heterogéneas y con focos hipoecoicos. El paciente recibió tratamiento con amoxicilina-clavulánico durante dos días por vía intravenosa, completando ocho días más por vía oral, analgesia y antiinflamatorios, con buena evolución posterior. La consulta de Infectología Pediátrica ha realizado el seguimiento del paciente, desde donde se ha completado el estudio. Se han realizado un estudio de inmunidad, que ha sido normal, pruebas reumatoideas, negativas y estudio serológico, negativo, excepto la serología vacunal antiparotiditis, que fue positiva. En la actualidad no ha presentado nuevos episodios desde hace más de un año.

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[ "NORMALIZABLES", "PROTEINAS" ]

human neutrophil alpha defensin 1 is a Genes & Molecular Sequences

11191_task0

Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Genes & Molecular Sequences

[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]

Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.

[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]

[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]

human neutrophil alpha defensin 1 is a Genes & Molecular Sequences

11191_task1

Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please typing these entity words according to sentence: human neutrophil alpha defensin 1 Options: Genes & Molecular Sequences

[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]

Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.

[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]

[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]

human neutrophil alpha defensin 1

11191_task2

Sentence: Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "I-Genes & Molecular Sequences", "O", "O", "O", "O" ]

Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.

[ "Molecular", "determinants", "for", "the", "interaction", "of", "human", "neutrophil", "alpha", "defensin", "1", "with", "its", "propeptide", "." ]

[ "Genes & Molecular Sequences", "Chemicals & Drugs" ]

cholesterol is a compound, low - density lipoprotein receptor is a protein

DS.d460_task0

Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]

Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.

[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]

[ "protein", "compound" ]

cholesterol is a compound, low - density lipoprotein receptor is a protein

DS.d460_task1

Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please typing these entity words according to sentence: cholesterol, low - density lipoprotein receptor Options: compound, protein

[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]

Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.

[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]

[ "protein", "compound" ]

cholesterol, low - density lipoprotein receptor

DS.d460_task2

Sentence: Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O" ]

Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.

[ "Brainstem", "concentrations", "of", "cholesterol", "are", "not", "influenced", "by", "genetic", "ablation", "of", "the", "low", "-", "density", "lipoprotein", "receptor", "." ]

[ "protein", "compound" ]

raloxifene is a Intervention_Pharmacological, bone turnover in postmenopausal women . is a Participant_Condition, accelerated bone loss following estrogen cessation . is a Participant_Condition, bone mineral density ( BMD ) is a Outcome_Physical, Women is a Participant_Sex, aged 50 to 80 years is a Participant_Age, n=20 is a Participant_Sample-size, or placebo is a Intervention_Control, n=14 is a Participant_Sample-size, no treatment . is a Intervention_Control, Bone turnover markers and bone density ( BMD ) is a Outcome_Physical, Raloxifene is a Intervention_Pharmacological, decrease in bone turnover is a Outcome_Physical, increase in spine BMD is a Outcome_Physical, hip BMD is a Outcome_Physical, bone markers is a Outcome_Physical, Hip BMD is a Outcome_Physical, Bone markers is a Outcome_Physical, Bone loss is a Outcome_Physical, accelerated bone loss . is a Participant_Condition

42563_task0

Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size

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The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Control", "Intervention_Pharmacological", "Participant_Sex", "Participant_Sample-size" ]

raloxifene is a Intervention_Pharmacological, bone turnover in postmenopausal women . is a Participant_Condition, accelerated bone loss following estrogen cessation . is a Participant_Condition, bone mineral density ( BMD ) is a Outcome_Physical, Women is a Participant_Sex, aged 50 to 80 years is a Participant_Age, n=20 is a Participant_Sample-size, or placebo is a Intervention_Control, n=14 is a Participant_Sample-size, no treatment . is a Intervention_Control, Bone turnover markers and bone density ( BMD ) is a Outcome_Physical, Raloxifene is a Intervention_Pharmacological, decrease in bone turnover is a Outcome_Physical, increase in spine BMD is a Outcome_Physical, hip BMD is a Outcome_Physical, bone markers is a Outcome_Physical, Hip BMD is a Outcome_Physical, Bone markers is a Outcome_Physical, Bone loss is a Outcome_Physical, accelerated bone loss . is a Participant_Condition

42563_task1

Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . Instructions: please typing these entity words according to sentence: raloxifene, bone turnover in postmenopausal women ., accelerated bone loss following estrogen cessation ., bone mineral density ( BMD ), Women, aged 50 to 80 years, n=20, or placebo, n=14, no treatment ., Bone turnover markers and bone density ( BMD ), Raloxifene, decrease in bone turnover, increase in spine BMD, hip BMD, bone markers, Hip BMD, Bone markers, Bone loss, accelerated bone loss . Options: Intervention_Pharmacological, Participant_Sex, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size

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The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Control", "Intervention_Pharmacological", "Participant_Sex", "Participant_Sample-size" ]

raloxifene, bone turnover in postmenopausal women ., accelerated bone loss following estrogen cessation ., bone mineral density ( BMD ), Women, aged 50 to 80 years, n=20, or placebo, n=14, no treatment ., Bone turnover markers and bone density ( BMD ), Raloxifene, decrease in bone turnover, increase in spine BMD, hip BMD, bone markers, Hip BMD, Bone markers, Bone loss, accelerated bone loss .

42563_task2

Sentence: The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment . Instructions: please extract entity words from the input sentence

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The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women . There is evidence to suggest accelerated bone loss following estrogen cessation . The effect of cessation of raloxifene therapy on bone turnover is unknown . Our aim was to determine the effect of cessation of raloxifene treatment on bone turnover and bone mineral density ( BMD ) in postmenopausal , osteopenic women . Women aged 50 to 80 years received raloxifene for 96 weeks and were then randomized to continue raloxifene ( group 1 , n=20 ) or placebo ( group 2 , n=20 ) for a further 96 weeks . A third group ( group 3 , n=14 ) received no treatment . Bone turnover markers and bone density ( BMD ) were measured throughout the study . Raloxifene treatment for 96 weeks resulted in a decrease in bone turnover ( PINP by 31 % ) and an increase in spine BMD ( by 2 % ) but no change in hip BMD for groups 1 and 2 . Continuation of raloxifene ( group 1 ) maintained these changes . Following cessation of raloxifene ( group 2 ) , bone markers returned to baseline levels ( by 120 weeks ) . Hip BMD was decreased by 2 % at 192 weeks compared to baseline . Bone markers in the controls ( group 3 ) remained at the upper limit of the reference range throughout , with decreases in BMD of 2.3 % ( spine ) and 2.8 % ( hip ) . Bone loss following cessation of raloxifene therapy at 96 weeks was greater than in the control group , suggesting accelerated bone loss . The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Age", "Intervention_Control", "Intervention_Pharmacological", "Participant_Sex", "Participant_Sample-size" ]

Hepatocellular carcinoma is an umlsterm, frequency is an umlsterm, Western world is an umlsterm, hepatitis C is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, Liver transplantation is an umlsterm, liver is an umlsterm, selection criteria is an umlsterm, patient is an umlsterm, evaluation is an umlsterm, complications is an umlsterm, cryotherapy is an umlsterm, Liver transplantation is an umlsterm, treatment is an umlsterm, line is an umlsterm, treatment is an umlsterm, patients is an umlsterm

DerChirurg.80690360.eng.abstr_task0

Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .

[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]

[ "umlsterm" ]

Hepatocellular carcinoma is an umlsterm, frequency is an umlsterm, Western world is an umlsterm, hepatitis C is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, Liver transplantation is an umlsterm, liver is an umlsterm, selection criteria is an umlsterm, patient is an umlsterm, evaluation is an umlsterm, complications is an umlsterm, cryotherapy is an umlsterm, Liver transplantation is an umlsterm, treatment is an umlsterm, line is an umlsterm, treatment is an umlsterm, patients is an umlsterm

DerChirurg.80690360.eng.abstr_task1

Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please typing these entity words according to sentence: Hepatocellular carcinoma, frequency, Western world, hepatitis C, therapy, treatment, tumor, control, Liver transplantation, liver, selection criteria, patient, evaluation, complications, cryotherapy, Liver transplantation, treatment, line, treatment, patients Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .

[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]

[ "umlsterm" ]

Hepatocellular carcinoma, frequency, Western world, hepatitis C, therapy, treatment, tumor, control, Liver transplantation, liver, selection criteria, patient, evaluation, complications, cryotherapy, Liver transplantation, treatment, line, treatment, patients

DerChirurg.80690360.eng.abstr_task2

Sentence: Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Hepatocellular carcinoma ( HCC ) is being diagnosed with increasing frequency in the Western world as a consequence of the hepatitis C epidemia . Multimodal therapy is now the only effective treatment option to offer a chance of complete tumor control in HCC . Liver transplantation and liver resection , including the selection criteria and patient evaluation , are discussed . The benefits and complications of transarterial chemoembolization and cryotherapy are also reviewed . Liver transplantation is now thought to offer the best treatment option in early HCC and should be regarded as the first line of treatment in selected patients .

[ "Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "being", "diagnosed", "with", "increasing", "frequency", "in", "the", "Western", "world", "as", "a", "consequence", "of", "the", "hepatitis", "C", "epidemia", ".", "Multimodal", "therapy", "is", "now", "the", "only", "effective", "treatment", "option", "to", "offer", "a", "chance", "of", "complete", "tumor", "control", "in", "HCC", ".", "Liver", "transplantation", "and", "liver", "resection", ",", "including", "the", "selection", "criteria", "and", "patient", "evaluation", ",", "are", "discussed", ".", "The", "benefits", "and", "complications", "of", "transarterial", "chemoembolization", "and", "cryotherapy", "are", "also", "reviewed", ".", "Liver", "transplantation", "is", "now", "thought", "to", "offer", "the", "best", "treatment", "option", "in", "early", "HCC", "and", "should", "be", "regarded", "as", "the", "first", "line", "of", "treatment", "in", "selected", "patients", "." ]

[ "umlsterm" ]

Glucose is a compound, insulin is a protein

DS.d784_task0

Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.

[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]

[ "compound", "protein" ]

Glucose is a compound, insulin is a protein

DS.d784_task1

Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please typing these entity words according to sentence: Glucose, insulin Options: compound, protein

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.

[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]

[ "compound", "protein" ]

Glucose, insulin

DS.d784_task2

Sentence: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Instructions: please extract entity words from the input sentence

[ "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.

[ "Glucose", "replacement", "to", "euglycemia", "causes", "hypoxia", ",", "acidosis", ",", "and", "decreased", "insulin", "secretion", "in", "fetal", "sheep", "with", "intrauterine", "growth", "restriction", "." ]

[ "compound", "protein" ]

plate is an umlsterm, anatomical is an umlsterm, joint is an umlsterm, fractures is an umlsterm, bone is an umlsterm, bone is an umlsterm, anatomical is an umlsterm, plate is an umlsterm, bone necrosis is an umlsterm, fracture is an umlsterm, callus is an umlsterm, Direct is an umlsterm, method is an umlsterm, bone is an umlsterm, necrosis is an umlsterm, bones is an umlsterm, plate is an umlsterm, method is an umlsterm, technique is an umlsterm, fractures is an umlsterm, Elasticity is an umlsterm, screws is an umlsterm, fracture is an umlsterm, titanium is an umlsterm, plate is an umlsterm, plate is an umlsterm, fitting is an umlsterm, screws is an umlsterm, devices is an umlsterm, intention is an umlsterm, fracture 's is an umlsterm, muscle is an umlsterm, fracture is an umlsterm, callus is an umlsterm, tissue is an umlsterm, bone is an umlsterm, accident is an umlsterm, University is an umlsterm, trauma is an umlsterm, fractures is an umlsterm, technique is an umlsterm, bone is an umlsterm, pseudoarthrosis is an umlsterm, bone infection is an umlsterm, risks of is an umlsterm, plate is an umlsterm, methods is an umlsterm, screws is an umlsterm

DerUnfallchirurg.60990816.eng.abstr_task0

Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .

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[ "umlsterm" ]

plate is an umlsterm, anatomical is an umlsterm, joint is an umlsterm, fractures is an umlsterm, bone is an umlsterm, bone is an umlsterm, anatomical is an umlsterm, plate is an umlsterm, bone necrosis is an umlsterm, fracture is an umlsterm, callus is an umlsterm, Direct is an umlsterm, method is an umlsterm, bone is an umlsterm, necrosis is an umlsterm, bones is an umlsterm, plate is an umlsterm, method is an umlsterm, technique is an umlsterm, fractures is an umlsterm, Elasticity is an umlsterm, screws is an umlsterm, fracture is an umlsterm, titanium is an umlsterm, plate is an umlsterm, plate is an umlsterm, fitting is an umlsterm, screws is an umlsterm, devices is an umlsterm, intention is an umlsterm, fracture 's is an umlsterm, muscle is an umlsterm, fracture is an umlsterm, callus is an umlsterm, tissue is an umlsterm, bone is an umlsterm, accident is an umlsterm, University is an umlsterm, trauma is an umlsterm, fractures is an umlsterm, technique is an umlsterm, bone is an umlsterm, pseudoarthrosis is an umlsterm, bone infection is an umlsterm, risks of is an umlsterm, plate is an umlsterm, methods is an umlsterm, screws is an umlsterm

DerUnfallchirurg.60990816.eng.abstr_task1

Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please typing these entity words according to sentence: plate, anatomical, joint, fractures, bone, bone, anatomical, plate, bone necrosis, fracture, callus, Direct, method, bone, necrosis, bones, plate, method, technique, fractures, Elasticity, screws, fracture, titanium, plate, plate, fitting, screws, devices, intention, fracture 's, muscle, fracture, callus, tissue, bone, accident, University, trauma, fractures, technique, bone, pseudoarthrosis, bone infection, risks of, plate, methods, screws Options: umlsterm

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Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .

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[ "umlsterm" ]

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DerUnfallchirurg.60990816.eng.abstr_task2

Sentence: Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws . Instructions: please extract entity words from the input sentence

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Classical stable plate osteosynthesis with its anatomical repositioning , absolute stability between fragments and medial support should only be applied to joint fractures and spongy bone . In cortical bone , the anatomical reposition connected with the plate promotes bone necrosis along the fracture and prevents callus formation . Direct cortical synthesis , a method also known as " primary bone healing " , serves the bone's revascularisation and is not necessarily aimed at healing . Thus , this may also be termed " necrosis healing " . Along the shaft of long bones , elastic plate osteosynthesis , a biological method , is safer than and superior to the rigid technique . This even applies to short oblique and transverse fractures insofar as nailing does not appear feasible . Elasticity is achieved by leaving a flexible stretch of at least 2 - 4 holes , i.e. as long as possible , without screws over the fracture and by employing a titanium plate . Thus , there is no punctate fatigue leading to plate breakage . The fitting of third fragments is deliberately left out . The same applies to all kinds of compression with lag screws , tension devices or DC-gliding holes - and this with the intention of allowing micromovements in the fracture's fissure . Periost and muscle are not removed and the fracture is not examined . Healing occurs spontaneously via a fixating callus forming within the first 3 - 6 weeks out of the periost-soft tissue combination . Histomorphological investigation dates the first woven- bone bridges between the fragments to 3 weeks subsequent to the accident . In Goettingen University trauma centre , 87 fractures have been attended to over 2 years using this technique . Despite considerable soft-tissue damage , no delayed bone healing , pseudoarthrosis or bone infection has been observed . The risks of elastic plate osteosynthesis lie in unbiological and exaggerated reposition methods , too short a flexible stretch , and insufficient anchorage of the screws .

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[ "umlsterm" ]

E - cadherin is a Gene/protein/RNA, alpha - catenin is a Gene/protein/RNA, beta - catenin is a Gene/protein/RNA

514_task0

Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.

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[ "Gene/protein/RNA" ]

E - cadherin is a Gene/protein/RNA, alpha - catenin is a Gene/protein/RNA, beta - catenin is a Gene/protein/RNA

514_task1

Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please typing these entity words according to sentence: E - cadherin, alpha - catenin, beta - catenin Options: Gene/protein/RNA

[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.

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[ "Gene/protein/RNA" ]

E - cadherin, alpha - catenin, beta - catenin

514_task2

Sentence: Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "B-Gene/protein/RNA", "I-Gene/protein/RNA", "I-Gene/protein/RNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Loss of memberanous expression of E-cadherin, alpha-catenin and beta-catenin was demonstrated in 52%, 85% and 40% of tumours respectively.

[ "Loss", "of", "memberanous", "expression", "of", "E", "-", "cadherin", ",", "alpha", "-", "catenin", "and", "beta", "-", "catenin", "was", "demonstrated", "in", "52", "%", ",", "85", "%", "and", "40", "%", "of", "tumours", "respectively", "." ]

[ "Gene/protein/RNA" ]

Pathogenic aspects is an umlsterm, interstitial cystitis is an umlsterm, literature is an umlsterm, criteria is an umlsterm, evidence - based medicine is an umlsterm, publications is an umlsterm, MEDLINE is an umlsterm, interstitial cystitis is an umlsterm, pathogenesis is an umlsterm, etiology is an umlsterm, criteria is an umlsterm, papers is an umlsterm

DerUrologeA.00390520.eng.abstr_task0

Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .

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[ "umlsterm" ]

Pathogenic aspects is an umlsterm, interstitial cystitis is an umlsterm, literature is an umlsterm, criteria is an umlsterm, evidence - based medicine is an umlsterm, publications is an umlsterm, MEDLINE is an umlsterm, interstitial cystitis is an umlsterm, pathogenesis is an umlsterm, etiology is an umlsterm, criteria is an umlsterm, papers is an umlsterm

DerUrologeA.00390520.eng.abstr_task1

Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please typing these entity words according to sentence: Pathogenic aspects, interstitial cystitis, literature, criteria, evidence - based medicine, publications, MEDLINE, interstitial cystitis, pathogenesis, etiology, criteria, papers Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .

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[ "umlsterm" ]

Pathogenic aspects, interstitial cystitis, literature, criteria, evidence - based medicine, publications, MEDLINE, interstitial cystitis, pathogenesis, etiology, criteria, papers

DerUrologeA.00390520.eng.abstr_task2

Sentence: Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pathogenic aspects of interstitial cystitis ( IC ) are reviewed on the basis of the current literature applying the criteria of evidence-based medicine ( EBM ) . Three hundred forty-six peer-reviewed publications of the past 30 years were retrieved via MEDLINE employing the key words " interstitial cystitis and pathogenesis or etiology " and classified according to EBM criteria and subject categories . The papers were then reviewed and summarized and are discussed considering the theory of acute and chronic inflammatory responses .

[ "Pathogenic", "aspects", "of", "interstitial", "cystitis", "(", "IC", ")", "are", "reviewed", "on", "the", "basis", "of", "the", "current", "literature", "applying", "the", "criteria", "of", "evidence", "-", "based", "medicine", "(", "EBM", ")", ".", "Three", "hundred", "forty", "-", "six", "peer", "-", "reviewed", "publications", "of", "the", "past", "30", "years", "were", "retrieved", "via", "MEDLINE", "employing", "the", "key", "words", "\"", "interstitial", "cystitis", "and", "pathogenesis", "or", "etiology", "\"", "and", "classified", "according", "to", "EBM", "criteria", "and", "subject", "categories", ".", "The", "papers", "were", "then", "reviewed", "and", "summarized", "and", "are", "discussed", "considering", "the", "theory", "of", "acute", "and", "chronic", "inflammatory", "responses", "." ]

[ "umlsterm" ]

Schilddruese is an umlsterm, Infektionen is an umlsterm, Bakterien is an umlsterm, Pilze is an umlsterm, Parasiten is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, Infektion is an umlsterm, Sepsis is an umlsterm, Infektionsdiagnostik is an umlsterm, Differentialdiagnose is an umlsterm, alkohol - toxischen is an umlsterm, Pankreatitis is an umlsterm, Transplantationsmedizin is an umlsterm, Komplikationen is an umlsterm

IntensiveMedizin.70340381.ger.abstr_task0

Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .

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[ "umlsterm" ]

Schilddruese is an umlsterm, Infektionen is an umlsterm, Bakterien is an umlsterm, Pilze is an umlsterm, Parasiten is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, Infektion is an umlsterm, Sepsis is an umlsterm, Infektionsdiagnostik is an umlsterm, Differentialdiagnose is an umlsterm, alkohol - toxischen is an umlsterm, Pankreatitis is an umlsterm, Transplantationsmedizin is an umlsterm, Komplikationen is an umlsterm

IntensiveMedizin.70340381.ger.abstr_task1

Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please typing these entity words according to sentence: Schilddruese, Infektionen, Bakterien, Pilze, Parasiten, Infektionen, Patienten, Infektion, Sepsis, Infektionsdiagnostik, Differentialdiagnose, alkohol - toxischen, Pankreatitis, Transplantationsmedizin, Komplikationen Options: umlsterm

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Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .

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[ "umlsterm" ]

Schilddruese, Infektionen, Bakterien, Pilze, Parasiten, Infektionen, Patienten, Infektion, Sepsis, Infektionsdiagnostik, Differentialdiagnose, alkohol - toxischen, Pankreatitis, Transplantationsmedizin, Komplikationen

IntensiveMedizin.70340381.ger.abstr_task2

Sentence: Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen . Instructions: please extract entity words from the input sentence

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Procalcitonin ist das hormonell inaktive Propeptid des Calcitonins . Bei Gesunden wird Procalcitonin in den C-Zellen der Schilddruese produziert und proteolytisch gespalten , so dass der Serumspiegel unter 0,1 ng/ml liegt . Bei schweren generalisierten Infektionen ( durch Bakterien , Pilze oder Parasiten ) mit systemischer Manifestation werden PCT-Serumspiegel bis zu 100 ng/ml erreicht . Schwere virale Infektionen und nicht-infektionsbedingte inflammatorische Reaktionen hingegen fuehren zu keiner oder nur geringer PCT-Erhoehung . Der Syntheseort dieses Procalcitonins ist noch unbekannt , sicher ist aber , dass auch sehr ausgepraegte Erhoehungen des Serumprocalcitoninspiegels nicht zu einem Ansteigen des Serumcalcitoninspiegels oder erhoehter Calcitoninaktivitaet fuehren . Procalcitoninverlaufskontrollen scheinen bei Patienten nuetzlich , die gefaehrdet sind , eine systemische Infektion bzw. Sepsis zu entwickeln . Ansteigende oder permanent erhoehte PCT-Werte stellen die Indikation fuer eine weitere Infektionsdiagnostik ( Focussuche ) dar . Die Procalcitoninbestimmung kann zur Unterscheidung zwischen infektioesen und nichtinfektioesen Ursachen bei der Differentialdiagnose von Erkrankungen , die mit den Zeichen der systemischen Inflammation einhergehen , hilfreich sein . Dies gilt auch fuer die Unterscheidung zwischen der infektioes-cholestatischen versus alkohol-toxischen Pankreatitis , des infektioesen versus nichtinfektioesen ARDS sowie in der Transplantationsmedizin zur Unterscheidung zwischen Abstossungsreaktionen und schweren infektioesen Komplikationen .

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[ "umlsterm" ]

cysteine tRNA synthetase is a Protein, cysteine tRNA synthetase is a Protein

579_task0

Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.

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[ "Protein" ]

cysteine tRNA synthetase is a Protein, cysteine tRNA synthetase is a Protein

579_task1

Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please typing these entity words according to sentence: cysteine tRNA synthetase, cysteine tRNA synthetase Options: Protein

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A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.

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[ "Protein" ]

cysteine tRNA synthetase, cysteine tRNA synthetase

579_task2

Sentence: A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition. Instructions: please extract entity words from the input sentence

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A strategy of tRNA recognition that includes determinants of RNA structure. Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is important for recognition of the tRNA by cysteine tRNA synthetase. This base pair is proposed to consist of N2:N3, rather than N1:O6, hydrogen bonds. The reproduction of the hydrogen pairing scheme of tRNA(Gly). This reproduction required an A13:A22 mismatch in the dihyrouridine stem. To determine if A13:A22 is a determinant of the structural features of G15:G48, we investigated the A15:U48 and A15:A48 variants of tRNA(Gly) which harbored specific substitutions of A13:A22. We show here that introduction of A13:A22 to both tRNA frameworks confers structural features similar to those of G15:G48 in E. coli tRNA(Cys). These structural features are accompanied by efficient recognition of both tRNAs by cysteine tRNA synthetase. Substitution of A13:A22 with U13:A22 alters the structural features at 15:48 and impairs tRNA recognition. The dependence on A13:22 for tRNA recognition has a distinct similarity to that of E. coli tRNA(Cys) and to that of the G15:G48 variant of tRNA(Gly). The results have implications for the design and manipulation of RNA structural elements as the basis for tRNA recognition.

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[ "Protein" ]

frequency is an umlsterm, hemochromatosis is an umlsterm, population is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, arthropathy is an umlsterm, patients is an umlsterm, rheumatology is an umlsterm, outpatient clinics is an umlsterm, patients is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, disorders is an umlsterm, All is an umlsterm, dysfunction is an umlsterm, iron overload is an umlsterm, life expectancy is an umlsterm, knowledge is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, complications is an umlsterm, iron overload is an umlsterm, patients is an umlsterm

ZfuerRheumatologie.70560156.eng.abstr_task0

Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .

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[ "umlsterm" ]

frequency is an umlsterm, hemochromatosis is an umlsterm, population is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, arthropathy is an umlsterm, patients is an umlsterm, rheumatology is an umlsterm, outpatient clinics is an umlsterm, patients is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, patients is an umlsterm, rheumatoid arthritis is an umlsterm, disorders is an umlsterm, All is an umlsterm, dysfunction is an umlsterm, iron overload is an umlsterm, life expectancy is an umlsterm, knowledge is an umlsterm, signs is an umlsterm, arthropathy is an umlsterm, diagnosis is an umlsterm, hemochromatosis is an umlsterm, complications is an umlsterm, iron overload is an umlsterm, patients is an umlsterm

ZfuerRheumatologie.70560156.eng.abstr_task1

Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please typing these entity words according to sentence: frequency, hemochromatosis, population, hemochromatosis, patients, arthropathy, patients, rheumatology, outpatient clinics, patients, signs, arthropathy, diagnosis, hemochromatosis, patients, rheumatoid arthritis, disorders, All, dysfunction, iron overload, life expectancy, knowledge, signs, arthropathy, diagnosis, hemochromatosis, complications, iron overload, patients Options: umlsterm

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Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .

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[ "umlsterm" ]

frequency, hemochromatosis, population, hemochromatosis, patients, arthropathy, patients, rheumatology, outpatient clinics, patients, signs, arthropathy, diagnosis, hemochromatosis, patients, rheumatoid arthritis, disorders, All, dysfunction, iron overload, life expectancy, knowledge, signs, arthropathy, diagnosis, hemochromatosis, complications, iron overload, patients

ZfuerRheumatologie.70560156.eng.abstr_task2

Sentence: Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients . Instructions: please extract entity words from the input sentence

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Recent studies have shown a high frequency of genetic hemochromatosis in the Caucasion population . In addition , the well known organ involvement of genetic hemochromatosis was evident ; more than 50% of patients develop a typical arthropathy which may result in severe physical disability . Among approximately 5000 patients referred to the rheumatology outpatient clinics of Bad Nauheim and Frankfurt with different rheumatologic diagnoses , 11 patients with typical signs of hemochromatotic arthropathy were identified . In none of those cases had the diagnosis " genetic hemochromatosis " been previously established . These patients had been treated for rheumatoid arthritis and other rheumatologic disorders over several years . All showed severe organ dysfunction due to iron overload , resulting in a reduced life expectancy . This investigation shows that knowledge of the typical signs of hemochromatotic arthropathy could lead to an earlier diagnosis of genetic hemochromatosis which is necessary to prevent the complications of iron overload in those patients .

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[ "umlsterm" ]

Behandlung is an umlsterm, Lysosomen is an umlsterm, Zellen is an umlsterm, Patienten is an umlsterm

DerOpthalmologe.70940147.ger.abstr_task0

Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .

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[ "umlsterm" ]

Behandlung is an umlsterm, Lysosomen is an umlsterm, Zellen is an umlsterm, Patienten is an umlsterm

DerOpthalmologe.70940147.ger.abstr_task1

Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please typing these entity words according to sentence: Behandlung, Lysosomen, Zellen, Patienten Options: umlsterm

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Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .

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[ "umlsterm" ]

Behandlung, Lysosomen, Zellen, Patienten

DerOpthalmologe.70940147.ger.abstr_task2

Sentence: Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die Chloroquinkeratopathie ist als eine reversible epitheliale Hornhauteinlagerung bekannt , die ohne direkten Zusammenhang mit der Dauer und Dosierung der Behandlung auftritt . Dabei kommt es zu einer Anreicherung von Chloroquin in den Lysosomen der Zellen . Ziel unserer Untersuchungen war es , mikroskopische Veraenderungen der Hornhaut bei Patienten infolge einer Chloroquintherapie in vivo zu erfassen .

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[ "umlsterm" ]

verhaltenstherapeutisch is an umlsterm, Psychotherapie is an umlsterm, Personalbemessung is an umlsterm, Methodik is an umlsterm, Therapie is an umlsterm, Teamtherapie is an umlsterm, Gruppentherapie is an umlsterm, verhaltenstherapeutischen is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Psychotherapie is an umlsterm, verhaltenstherapeutische is an umlsterm, Methoden is an umlsterm

Psychotherapeut.80430265.ger.abstr_task0

Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .

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[ "umlsterm" ]

verhaltenstherapeutisch is an umlsterm, Psychotherapie is an umlsterm, Personalbemessung is an umlsterm, Methodik is an umlsterm, Therapie is an umlsterm, Teamtherapie is an umlsterm, Gruppentherapie is an umlsterm, verhaltenstherapeutischen is an umlsterm, Patienten is an umlsterm, Zeit is an umlsterm, Psychotherapie is an umlsterm, verhaltenstherapeutische is an umlsterm, Methoden is an umlsterm

Psychotherapeut.80430265.ger.abstr_task1

Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please typing these entity words according to sentence: verhaltenstherapeutisch, Psychotherapie, Personalbemessung, Methodik, Therapie, Teamtherapie, Gruppentherapie, verhaltenstherapeutischen, Patienten, Zeit, Psychotherapie, verhaltenstherapeutische, Methoden Options: umlsterm

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In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .

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[ "umlsterm" ]

verhaltenstherapeutisch, Psychotherapie, Personalbemessung, Methodik, Therapie, Teamtherapie, Gruppentherapie, verhaltenstherapeutischen, Patienten, Zeit, Psychotherapie, verhaltenstherapeutische, Methoden

Psychotherapeut.80430265.ger.abstr_task2

Sentence: In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt . Instructions: please extract entity words from the input sentence

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In dieser Uebersichtsarbeit wird die Entwicklung der psychoanalytisch und verhaltenstherapeutisch begruendeten stationaeren Psychotherapie als eigenstaendiger spezieller Versorgungsbereich fuer sogenannte psychogene Stoerungen dargestellt . Die strukturellen Eckdaten wie Groesse der Einrichtungen als Abteilung oder Fachklinik , Finanzierung , Verweildauer und Personalbemessung werden diskutiert . Ein Schwerpunkt wird auf die Entwicklung der Methodik gelegt . In den psychoanalytisch begruendeten Konzepten steht gemaess der psychoanalytischen Therapie die multimodale Teamtherapie unter Beruecksichtigung der multidimensionalen Uebertragungsprozesse mit dem Schwerpunkt auf Gruppentherapie im Vordergrund . In den verhaltenstherapeutischen Konzepten stehen die stoerungsspezifischen , psychoedukativen , einzel- und gruppentherapeutischen Konzepte mit dem zentralen Ziel , das Selbstmanagement des Patienten fuer seine Erkrankung zu verbessern im Vordergrund . In der juengsten Zeit werden in der psychoanalytisch begruendeten stationaeren Psychotherapie zunehmend verhaltenstherapeutische Methoden integriert und umgekehrt .

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[ "umlsterm" ]

Sitagliptin is a CHEMICAL

17352516_task0

Sentence: Sitagliptin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "B-CHEMICAL", "O" ]

Sitagliptin.

[ "Sitagliptin", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Sitagliptin is a CHEMICAL

17352516_task1

Sentence: Sitagliptin. Instructions: please typing these entity words according to sentence: Sitagliptin Options: CHEMICAL

[ "B-CHEMICAL", "O" ]

Sitagliptin.

[ "Sitagliptin", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

Sitagliptin

17352516_task2

Sentence: Sitagliptin. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "O" ]

Sitagliptin.

[ "Sitagliptin", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

out - of - pocket costs is an outcome, time on caregiving activities is an outcome

958_task0

Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: outcome

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O" ]

In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .

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[ "outcome" ]

out - of - pocket costs is an outcome, time on caregiving activities is an outcome

958_task1

Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please typing these entity words according to sentence: out - of - pocket costs, time on caregiving activities Options: outcome

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In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .

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[ "outcome" ]

out - of - pocket costs, time on caregiving activities

958_task2

Sentence: In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O" ]

In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .

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[ "outcome" ]

citoqueratinas is a PROTEINAS, vimentina is a PROTEINAS

16_task0

Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: PROTEINAS

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Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.

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[ "PROTEINAS" ]

citoqueratinas is a PROTEINAS, vimentina is a PROTEINAS

16_task1

Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please typing these entity words according to sentence: citoqueratinas, vimentina Options: PROTEINAS

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Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.

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[ "PROTEINAS" ]

citoqueratinas, vimentina

16_task2

Sentence: Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa. Instructions: please extract entity words from the input sentence

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Varón de 80 años que debutó clínicamente con hematuria y dolor en flanco izquierdo. La puñopercusión en fosa renal izquierda fue positiva. Mediante técnicas de imagen se observó una masa a nivel de fosa renal izquierda que desdibujaba la silueta renal. El paciente fue intervenido realizándose una nefrectomía con ureterectomía proximal. En la pieza de nefrectomía el parénquima renal estaba sustituido en su práctica totalidad por una lesión blanquecina heterogénea en cuyo seno se podían apreciar cavidades quísticas de aspecto necrótico con formaciones papilares friables y mal delimitadas intracavitarias y áreas amarillentas mal delimitadas combinadas al azar con otras de aspecto necrótico y/o hemorrágico. Al corte se observó una consistencia firme, fundamentalmente correspondiendo con las áreas blanquecinogrisaceas si bien en otras localizaciones se apreció una consistencia blanda e incluso crujiente. El estudio histológico demostró una neoplasia constituida por una proliferación de células fusiformes y poligonales con marcada atípia y pleomorfismo nuclear, que adoptaba un patrón sólido de crecimiento. Más del 75% de la misma mostraba diferenciación a osteo y condrosarcoma si bien también se pudo demostrar diferenciación escamosa, principalmente tapizando la superficie interna de las formaciones quísticas previamente descritas. La elevada atipia celular observada se hacía más evidente con la presencia de abundantes células gigantes multinucleadas situadas en el seno de las áreas sólidas fusiformes y en torno a las áreas de diferenciación osteosarcomatosa (14) (seguramente estas últimas sean en realidad osteoclastos atípicos). El tumor contactaba con la cápsula renal sin sobrepasarla, invadiendo estructuras vasculares del hilio y el tejido adiposo de la pelvis. Tras un muestreo riguroso de la pieza quirúrgica se pudieron objetivar escasos focos con patrón histológico de carcinoma de células claras. El estudio inmunohistoquímico de la neoplasia mostró inmunotinción positiva para citoqueratinas tanto en el componente de células claras como en el fusocelular siendo este último igualmente positivo para vimentina (13). Con todo ello se emitió el diagnóstico de carcinoma sarcomatoide renal con predominio de áreas con diferenciación heteróloga maligna (osteo y condrosarcoma), haciendo referencia a la presencia de focos de carcinoma con patrón de células claras y de áreas con diferenciación escamosa.

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[ "PROTEINAS" ]

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MundKieferGesichtschirurgie.8002s135.eng.abstr_task0

Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .

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[ "umlsterm" ]

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MundKieferGesichtschirurgie.8002s135.eng.abstr_task1

Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please typing these entity words according to sentence: aim, evaluation, radiotranslucent, headholder, diagnosis, pathology, prospective study, patients, pathology, Philips, apparatus, head, control group, patients, pathology, computed tomography, headholder, findings, CT scans, assessment, disease, motion, artifacts, posture, head, headholder, diagnosis, computed tomography, posture, head, motion, artifacts Options: umlsterm

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The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .

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[ "umlsterm" ]

aim, evaluation, radiotranslucent, headholder, diagnosis, pathology, prospective study, patients, pathology, Philips, apparatus, head, control group, patients, pathology, computed tomography, headholder, findings, CT scans, assessment, disease, motion, artifacts, posture, head, headholder, diagnosis, computed tomography, posture, head, motion, artifacts

MundKieferGesichtschirurgie.8002s135.eng.abstr_task2

Sentence: The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult . Instructions: please extract entity words from the input sentence

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The aim of this study was the evaluation of a newly developed radiotranslucent headholder ( craniostat ) in order to improve diagnosis of maxillofacial pathology . In this prospective study , 103 patients with maxillofacial pathology were examined preoperatively with a Philips SR 7000 computed tomograph using this craniostat . The apparatus was applied fixing the patient's head at three points ( meatus acusticus externus on both sides and the glabella ) . The control group consisted of 106 patients with similar pathology who were examined by computed tomography without a headholder . The application of the craniostat resulted in the following advantageous findings : ( 1 ) reproducible CT scans , therefore very precise assessment of the course of a disease ; ( 2 ) fewer motion artifacts ; and ( 3 ) symmetrical posture of the patient's head . This headholder is helpful in improving maxillofacial diagnosis by computed tomography if a symmetrical , reproducible posture of the patient's head is to be achieved and motion artifacts could otherwise make the interpretation of the resulting images much more difficult .

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[ "umlsterm" ]

Maternal nutrition is an umlsterm, pregnancy is an umlsterm, lactation is an umlsterm, preventive is an umlsterm, health is an umlsterm, child is an umlsterm, nutritional status is an umlsterm, mother is an umlsterm, nutrition is an umlsterm, weight gain is an umlsterm, Diseases is an umlsterm, mother is an umlsterm, diet is an umlsterm, diabetes mellitus is an umlsterm, maternal PKU is an umlsterm, nutrition is an umlsterm, pregnancy is an umlsterm, 3rd trimester is an umlsterm, energy supply is an umlsterm, minerals is an umlsterm, vitamins is an umlsterm, acids is an umlsterm, iron is an umlsterm, magnesium is an umlsterm, zinc is an umlsterm, iodine is an umlsterm, folic acid is an umlsterm, vitamin is an umlsterm, deficiencies is an umlsterm, pregnancy is an umlsterm, health is an umlsterm, baby is an umlsterm, spontaneous abortions is an umlsterm, prematurity is an umlsterm, low birth weight is an umlsterm, birth defects is an umlsterm, dysfunctions is an umlsterm

MonatsschriftKinderheilkunde.8146s073.eng.abstr_task0

Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .

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[ "umlsterm" ]

Maternal nutrition is an umlsterm, pregnancy is an umlsterm, lactation is an umlsterm, preventive is an umlsterm, health is an umlsterm, child is an umlsterm, nutritional status is an umlsterm, mother is an umlsterm, nutrition is an umlsterm, weight gain is an umlsterm, Diseases is an umlsterm, mother is an umlsterm, diet is an umlsterm, diabetes mellitus is an umlsterm, maternal PKU is an umlsterm, nutrition is an umlsterm, pregnancy is an umlsterm, 3rd trimester is an umlsterm, energy supply is an umlsterm, minerals is an umlsterm, vitamins is an umlsterm, acids is an umlsterm, iron is an umlsterm, magnesium is an umlsterm, zinc is an umlsterm, iodine is an umlsterm, folic acid is an umlsterm, vitamin is an umlsterm, deficiencies is an umlsterm, pregnancy is an umlsterm, health is an umlsterm, baby is an umlsterm, spontaneous abortions is an umlsterm, prematurity is an umlsterm, low birth weight is an umlsterm, birth defects is an umlsterm, dysfunctions is an umlsterm

MonatsschriftKinderheilkunde.8146s073.eng.abstr_task1

Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please typing these entity words according to sentence: Maternal nutrition, pregnancy, lactation, preventive, health, child, nutritional status, mother, nutrition, weight gain, Diseases, mother, diet, diabetes mellitus, maternal PKU, nutrition, pregnancy, 3rd trimester, energy supply, minerals, vitamins, acids, iron, magnesium, zinc, iodine, folic acid, vitamin, deficiencies, pregnancy, health, baby, spontaneous abortions, prematurity, low birth weight, birth defects, dysfunctions Options: umlsterm

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Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .

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[ "umlsterm" ]

Maternal nutrition, pregnancy, lactation, preventive, health, child, nutritional status, mother, nutrition, weight gain, Diseases, mother, diet, diabetes mellitus, maternal PKU, nutrition, pregnancy, 3rd trimester, energy supply, minerals, vitamins, acids, iron, magnesium, zinc, iodine, folic acid, vitamin, deficiencies, pregnancy, health, baby, spontaneous abortions, prematurity, low birth weight, birth defects, dysfunctions

MonatsschriftKinderheilkunde.8146s073.eng.abstr_task2

Sentence: Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions . Instructions: please extract entity words from the input sentence

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Maternal nutrition during pregnancy and lactation has great preventive importance for the health of the young child . Important determinants are the pregravid nutritional status of the mother , the quantity and quality of the nutrition and gestational weight gain . Diseases of the mother that have to be treated by a special diet like diabetes mellitus or maternal PKU can complicate the maternal situation . Optimal nutrition during pregnancy includes at least in the 2nd or 3rd trimester increased energy supply ( +300 kcal/day ) and an increase in all nutrients , including minerals and vitamins . Of special importance are -3-fatty acids , iron , magnesium , zinc , iodine , and folic acid , vita-min B12 and vitamin K. Under- and overnu-trition and deficiencies in the above nutrients may have an influence on the outcome of pregnancy and the health of the baby : more spontaneous abortions , prematurity , low birth weight , birth defects , intra- and extrauterine developmental disturbances and organ dysfunctions .

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[ "umlsterm" ]

Stroke is an umlsterm, Prevention is an umlsterm, Ischaemia is an umlsterm, randomised clinical trial is an umlsterm, patients is an umlsterm, cerebral ischaemia is an umlsterm, origin is an umlsterm, anticoagulation is an umlsterm, international normalized ratio is an umlsterm, INR is an umlsterm, acetylsalicylic acid is an umlsterm, dipyridamole is an umlsterm, acetylsalicylic acid is an umlsterm, patients is an umlsterm, death is an umlsterm, stroke is an umlsterm, myocardial infarction is an umlsterm, complication is an umlsterm, outcome assessment is an umlsterm, multicentre study is an umlsterm, hospitals is an umlsterm, Netherlands is an umlsterm, Europe is an umlsterm, Australia is an umlsterm

DerNervenarzt.90700368.eng.abstr_task0

Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .

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[ "umlsterm" ]

Stroke is an umlsterm, Prevention is an umlsterm, Ischaemia is an umlsterm, randomised clinical trial is an umlsterm, patients is an umlsterm, cerebral ischaemia is an umlsterm, origin is an umlsterm, anticoagulation is an umlsterm, international normalized ratio is an umlsterm, INR is an umlsterm, acetylsalicylic acid is an umlsterm, dipyridamole is an umlsterm, acetylsalicylic acid is an umlsterm, patients is an umlsterm, death is an umlsterm, stroke is an umlsterm, myocardial infarction is an umlsterm, complication is an umlsterm, outcome assessment is an umlsterm, multicentre study is an umlsterm, hospitals is an umlsterm, Netherlands is an umlsterm, Europe is an umlsterm, Australia is an umlsterm

DerNervenarzt.90700368.eng.abstr_task1

Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please typing these entity words according to sentence: Stroke, Prevention, Ischaemia, randomised clinical trial, patients, cerebral ischaemia, origin, anticoagulation, international normalized ratio, INR, acetylsalicylic acid, dipyridamole, acetylsalicylic acid, patients, death, stroke, myocardial infarction, complication, outcome assessment, multicentre study, hospitals, Netherlands, Europe, Australia Options: umlsterm

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The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .

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[ "umlsterm" ]

Stroke, Prevention, Ischaemia, randomised clinical trial, patients, cerebral ischaemia, origin, anticoagulation, international normalized ratio, INR, acetylsalicylic acid, dipyridamole, acetylsalicylic acid, patients, death, stroke, myocardial infarction, complication, outcome assessment, multicentre study, hospitals, Netherlands, Europe, Australia

DerNervenarzt.90700368.eng.abstr_task2

Sentence: The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate . Instructions: please extract entity words from the input sentence

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The European and Australian Stroke Prevention in Reversible Ischaemia Trial ( ESPRIT ) is a randomised clinical trial in which patients with cerebral ischaemia of arterial origin will be randomised between oral anticoagulation ( international normalized ratio ( INR ) : 2.0-3.0), the combination of acetylsalicylic acid ( in any dose between 30 and 325 mg per day ) plus dipyridamole ( 400 mg daily ) and acetylsalicylic acid only ( in any dose between 30 and 325 mg per day ) . It is planned to enroll 4500 patients with a mean follow-up of three years . Primary outcome is the composite event of vascular death , stroke , myocardial infarction , or major bleeding complication ; outcome assessment will be blinded . ESPRIT is an international , multicentre study in which 60-80 hospitals in the Netherlands and other countries in Europe and Australia will participate .

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[ "umlsterm" ]