id
stringlengths 5
32
| document_id
stringlengths 5
32
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
Levamisole_ddi | Levamisole_ddi | [
{
"id": "Levamisole_ddi__text",
"type": "abstract",
"text": [
"ERGAMISOL (levamisole hydrochloride) has been reported to produce ANTABUSE-like side effects when given concomitantly with alcohol. The physician is advised to monitor plasma levels of phenytoin and to decrease the dose if necessary. Because of reports of prolongation of the prothrombin time beyond the therapeutic range in patients taking concurrent levamisole and warfarin sodium, it is suggested that the prothrombin time be monitored carefully, and the dose of warfarin sodium or other coumarin-like drugs should be adjusted accordingly, in patients taking both drugs."
],
"offsets": [
[
0,
574
]
]
}
] | [
{
"id": "Levamisole_ddi_T1",
"type": "BRAND",
"text": [
"ERGAMISOL"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T2",
"type": "DRUG",
"text": [
"levamisole hydrochloride"
],
"offsets": [
[
12,
36
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T3",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
124,
131
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T4",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
186,
195
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T5",
"type": "DRUG",
"text": [
"levamisole"
],
"offsets": [
[
353,
363
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T6",
"type": "DRUG",
"text": [
"warfarin sodium"
],
"offsets": [
[
368,
383
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T7",
"type": "DRUG",
"text": [
"warfarin sodium"
],
"offsets": [
[
467,
482
]
],
"normalized": []
},
{
"id": "Levamisole_ddi_T8",
"type": "GROUP",
"text": [
"coumarin"
],
"offsets": [
[
492,
500
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Levamisole_ddi_R1",
"type": "EFFECT",
"arg1_id": "Levamisole_ddi_T1",
"arg2_id": "Levamisole_ddi_T3",
"normalized": []
},
{
"id": "Levamisole_ddi_R2",
"type": "EFFECT",
"arg1_id": "Levamisole_ddi_T2",
"arg2_id": "Levamisole_ddi_T3",
"normalized": []
},
{
"id": "Levamisole_ddi_R3",
"type": "ADVISE",
"arg1_id": "Levamisole_ddi_T5",
"arg2_id": "Levamisole_ddi_T6",
"normalized": []
}
] |
Azithromycin_ddi | Azithromycin_ddi | [
{
"id": "Azithromycin_ddi__text",
"type": "abstract",
"text": [
"Co-administration of nelfinavir at steady-state with a single dose of azithromycin. Co-administration of nelfinavir at steady-state with a single dose of azithromycin (2 x 600 mg tablets) results in increased azithromycin serum concentrations. Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known side effects of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted. Azithromycin did not affect the prothrombin time response to a single dose of warfarin. However, prudent medical practice dictates careful monitoring of prothrombin time in all patients treated with azithromycin and warfarin concomitantly. Concurrent use of macrolides and warfarin in clinical practice has been associated with increased anticoagulant effects. Drug interaction studies were performed with azithromycin and other drugs likely to be co-administered. When used in therapeutic doses, azithromycin had a modest effect on the pharmacokinetics of atorvastatin, carbamazepine, cetirizine, didanosine, efavirenz, fluconazole, indinavir, midazolam, rifabutin, sildenafil, theophylline (intravenous and oral), triazolam, trimethoprim/sulfamethoxazole or zidovudine. Co-administration with efavirenz or fluconazole had a modest effect on the pharmacokinetics of azithromycin. No dosage adjustment of either drug is recommended when azithromycin is co administered with any of the above agents. Interactions with the drugs listed below have not been reported in clinical trials with azithromycin; however, no specific drug interaction studies have been performed to evaluate potential drug-drug interaction. Nonetheless, they have been observed with macrolide products. Until further data are developed regarding drug interactions when azithromycin and these drugs are used concomitantly, careful monitoring of patients is advised: Digoxin elevated digoxin concentrations. Ergotamine or dihydroergotamine acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia. Cyclosporine, hexobarbital and phenytoin concentrations. Laboratory Test Interactions There are no reported laboratory test interactions. Repeat Treatment Studies evaluating the use of repeated courses of Zmax have not been conducted."
],
"offsets": [
[
0,
2312
]
]
}
] | [
{
"id": "Azithromycin_ddi_T1",
"type": "DRUG",
"text": [
"nelfinavir"
],
"offsets": [
[
21,
31
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T2",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
70,
82
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T3",
"type": "DRUG",
"text": [
"nelfinavir"
],
"offsets": [
[
105,
115
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T4",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
154,
166
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T5",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
209,
221
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T6",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
274,
286
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T7",
"type": "DRUG",
"text": [
"nelfinavir"
],
"offsets": [
[
344,
354
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T8",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
399,
411
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T9",
"type": "DRUG",
"text": [
"Azithromycin"
],
"offsets": [
[
486,
498
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T10",
"type": "DRUG",
"text": [
"warfarin"
],
"offsets": [
[
564,
572
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T11",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
685,
697
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T12",
"type": "DRUG",
"text": [
"warfarin"
],
"offsets": [
[
702,
710
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T13",
"type": "GROUP",
"text": [
"macrolides"
],
"offsets": [
[
744,
754
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T14",
"type": "DRUG",
"text": [
"warfarin"
],
"offsets": [
[
759,
767
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T15",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
892,
904
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T16",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
983,
995
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T17",
"type": "DRUG",
"text": [
"atorvastatin"
],
"offsets": [
[
1043,
1055
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T18",
"type": "DRUG",
"text": [
"carbamazepine"
],
"offsets": [
[
1057,
1070
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T19",
"type": "DRUG",
"text": [
"cetirizine"
],
"offsets": [
[
1072,
1082
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T20",
"type": "DRUG",
"text": [
"didanosine"
],
"offsets": [
[
1084,
1094
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T21",
"type": "DRUG",
"text": [
"efavirenz"
],
"offsets": [
[
1096,
1105
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T22",
"type": "DRUG",
"text": [
"fluconazole"
],
"offsets": [
[
1107,
1118
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T23",
"type": "DRUG",
"text": [
"indinavir"
],
"offsets": [
[
1120,
1129
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T24",
"type": "DRUG",
"text": [
"midazolam"
],
"offsets": [
[
1131,
1140
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T25",
"type": "DRUG",
"text": [
"rifabutin"
],
"offsets": [
[
1142,
1151
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T26",
"type": "DRUG",
"text": [
"sildenafil"
],
"offsets": [
[
1153,
1163
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T27",
"type": "DRUG",
"text": [
"theophylline"
],
"offsets": [
[
1165,
1177
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T28",
"type": "DRUG",
"text": [
"triazolam"
],
"offsets": [
[
1202,
1211
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T29",
"type": "DRUG",
"text": [
"trimethoprim"
],
"offsets": [
[
1213,
1225
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T30",
"type": "DRUG",
"text": [
"sulfamethoxazole"
],
"offsets": [
[
1226,
1242
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T31",
"type": "DRUG",
"text": [
"zidovudine"
],
"offsets": [
[
1246,
1256
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T32",
"type": "DRUG",
"text": [
"efavirenz"
],
"offsets": [
[
1281,
1290
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T33",
"type": "DRUG",
"text": [
"fluconazole"
],
"offsets": [
[
1294,
1305
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T34",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
1353,
1365
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T35",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
1423,
1435
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T36",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
1573,
1585
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T37",
"type": "GROUP",
"text": [
"macrolide products"
],
"offsets": [
[
1740,
1758
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T38",
"type": "DRUG",
"text": [
"azithromycin"
],
"offsets": [
[
1826,
1838
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T39",
"type": "DRUG",
"text": [
"Digoxin"
],
"offsets": [
[
1922,
1929
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T40",
"type": "DRUG",
"text": [
"digoxin"
],
"offsets": [
[
1939,
1946
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T41",
"type": "DRUG",
"text": [
"Ergotamine"
],
"offsets": [
[
1963,
1973
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T42",
"type": "DRUG",
"text": [
"dihydroergotamine"
],
"offsets": [
[
1977,
1994
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T43",
"type": "DRUG",
"text": [
"Cyclosporine"
],
"offsets": [
[
2078,
2090
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T44",
"type": "DRUG",
"text": [
"hexobarbital"
],
"offsets": [
[
2092,
2104
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T45",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
2109,
2118
]
],
"normalized": []
},
{
"id": "Azithromycin_ddi_T46",
"type": "BRAND",
"text": [
"Zmax"
],
"offsets": [
[
2283,
2287
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Azithromycin_ddi_R1",
"type": "EFFECT",
"arg1_id": "Azithromycin_ddi_T3",
"arg2_id": "Azithromycin_ddi_T4",
"normalized": []
},
{
"id": "Azithromycin_ddi_R2",
"type": "ADVISE",
"arg1_id": "Azithromycin_ddi_T6",
"arg2_id": "Azithromycin_ddi_T7",
"normalized": []
},
{
"id": "Azithromycin_ddi_R3",
"type": "ADVISE",
"arg1_id": "Azithromycin_ddi_T11",
"arg2_id": "Azithromycin_ddi_T12",
"normalized": []
},
{
"id": "Azithromycin_ddi_R4",
"type": "EFFECT",
"arg1_id": "Azithromycin_ddi_T13",
"arg2_id": "Azithromycin_ddi_T14",
"normalized": []
},
{
"id": "Azithromycin_ddi_R5",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T17",
"normalized": []
},
{
"id": "Azithromycin_ddi_R6",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T18",
"normalized": []
},
{
"id": "Azithromycin_ddi_R7",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T19",
"normalized": []
},
{
"id": "Azithromycin_ddi_R8",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T20",
"normalized": []
},
{
"id": "Azithromycin_ddi_R9",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T21",
"normalized": []
},
{
"id": "Azithromycin_ddi_R10",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T22",
"normalized": []
},
{
"id": "Azithromycin_ddi_R11",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T23",
"normalized": []
},
{
"id": "Azithromycin_ddi_R12",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T24",
"normalized": []
},
{
"id": "Azithromycin_ddi_R13",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T25",
"normalized": []
},
{
"id": "Azithromycin_ddi_R14",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T26",
"normalized": []
},
{
"id": "Azithromycin_ddi_R15",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T27",
"normalized": []
},
{
"id": "Azithromycin_ddi_R16",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T28",
"normalized": []
},
{
"id": "Azithromycin_ddi_R17",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T29",
"normalized": []
},
{
"id": "Azithromycin_ddi_R18",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T30",
"normalized": []
},
{
"id": "Azithromycin_ddi_R19",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T16",
"arg2_id": "Azithromycin_ddi_T31",
"normalized": []
},
{
"id": "Azithromycin_ddi_R20",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T32",
"arg2_id": "Azithromycin_ddi_T34",
"normalized": []
},
{
"id": "Azithromycin_ddi_R21",
"type": "MECHANISM",
"arg1_id": "Azithromycin_ddi_T33",
"arg2_id": "Azithromycin_ddi_T34",
"normalized": []
}
] |
Darbepoetin alfa_ddi | Darbepoetin alfa_ddi | [
{
"id": "Darbepoetin alfa_ddi__text",
"type": "abstract",
"text": [
"No formal drug interaction studies of Aranesp have been performed."
],
"offsets": [
[
0,
67
]
]
}
] | [
{
"id": "Darbepoetin alfa_ddi_T1",
"type": "BRAND",
"text": [
"Aranesp"
],
"offsets": [
[
38,
45
]
],
"normalized": []
}
] | [] | [] | [] |
Buprenorphine_ddi | Buprenorphine_ddi | [
{
"id": "Buprenorphine_ddi__text",
"type": "abstract",
"text": [
"Buprenorphine is metabolized to norbuprenorphine by cytochrome CYP 3A4. Because CYP 3A4 inhibitors may increase plasma concentrations of buprenorphine, patients already on CYP 3A4 inhibitors such as azole antifungals (e.g. ketoconazole), macrolide antibiotics (e.g. erythromycin), and HIV protease inhibitors (e.g. ritonavir, indinavir and saquinavir) should have their dose of SUBUTEX or SUBOXONE adjusted. Based on anecdotal reports, there may be an interaction between buprenorphine and benzodiazepines. There have been a number of reports in the post-marketing experience of coma and death associated with the concomitant intravenous misuse of buprenorphine and benzodiazepines by addicts. In many of these cases, buprenorphine was misused by self-injection of crushed SUBUTEX tablets. SUBUTEX and SUBOXONE should be prescribed with caution to patients on benzodiazepines or other drugs that act on the central nervous system, regardless of whether these drugs are taken on the advice of a physician or are taken as drugs of abuse. Patients should be warned of the potential danger of the intravenous self-administration of benzodiazepines while under treatment with SUBOXONE or SUBUTEX."
],
"offsets": [
[
0,
1191
]
]
}
] | [
{
"id": "Buprenorphine_ddi_T1",
"type": "DRUG",
"text": [
"Buprenorphine"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T2",
"type": "DRUG_N",
"text": [
"norbuprenorphine"
],
"offsets": [
[
32,
48
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T3",
"type": "DRUG",
"text": [
"buprenorphine"
],
"offsets": [
[
137,
150
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T4",
"type": "GROUP",
"text": [
"azole antifungals"
],
"offsets": [
[
199,
216
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T5",
"type": "DRUG",
"text": [
"ketoconazole"
],
"offsets": [
[
223,
235
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T6",
"type": "GROUP",
"text": [
"macrolide antibiotics"
],
"offsets": [
[
238,
259
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T7",
"type": "DRUG",
"text": [
"erythromycin"
],
"offsets": [
[
266,
278
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T8",
"type": "GROUP",
"text": [
"HIV protease inhibitors"
],
"offsets": [
[
285,
308
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T9",
"type": "DRUG",
"text": [
"ritonavir"
],
"offsets": [
[
315,
324
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T10",
"type": "DRUG",
"text": [
"indinavir"
],
"offsets": [
[
326,
335
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T11",
"type": "DRUG",
"text": [
"saquinavir"
],
"offsets": [
[
340,
350
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T12",
"type": "BRAND",
"text": [
"SUBUTEX"
],
"offsets": [
[
378,
385
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T13",
"type": "BRAND",
"text": [
"SUBOXONE"
],
"offsets": [
[
389,
397
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T14",
"type": "DRUG",
"text": [
"buprenorphine"
],
"offsets": [
[
472,
485
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T15",
"type": "GROUP",
"text": [
"benzodiazepines"
],
"offsets": [
[
490,
505
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T16",
"type": "DRUG",
"text": [
"buprenorphine"
],
"offsets": [
[
648,
661
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T17",
"type": "DRUG",
"text": [
"benzodiazepines"
],
"offsets": [
[
666,
681
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T18",
"type": "DRUG",
"text": [
"buprenorphine"
],
"offsets": [
[
718,
731
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T19",
"type": "BRAND",
"text": [
"SUBUTEX"
],
"offsets": [
[
773,
780
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T20",
"type": "BRAND",
"text": [
"SUBUTEX"
],
"offsets": [
[
790,
797
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T21",
"type": "BRAND",
"text": [
"SUBOXONE"
],
"offsets": [
[
802,
810
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T22",
"type": "GROUP",
"text": [
"benzodiazepines"
],
"offsets": [
[
860,
875
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T23",
"type": "GROUP",
"text": [
"benzodiazepines"
],
"offsets": [
[
1128,
1143
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T24",
"type": "BRAND",
"text": [
"SUBOXONE"
],
"offsets": [
[
1171,
1179
]
],
"normalized": []
},
{
"id": "Buprenorphine_ddi_T25",
"type": "BRAND",
"text": [
"SUBUTEX"
],
"offsets": [
[
1183,
1190
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Buprenorphine_ddi_R1",
"type": "INT",
"arg1_id": "Buprenorphine_ddi_T14",
"arg2_id": "Buprenorphine_ddi_T15",
"normalized": []
},
{
"id": "Buprenorphine_ddi_R2",
"type": "EFFECT",
"arg1_id": "Buprenorphine_ddi_T16",
"arg2_id": "Buprenorphine_ddi_T17",
"normalized": []
},
{
"id": "Buprenorphine_ddi_R3",
"type": "ADVISE",
"arg1_id": "Buprenorphine_ddi_T20",
"arg2_id": "Buprenorphine_ddi_T22",
"normalized": []
},
{
"id": "Buprenorphine_ddi_R4",
"type": "ADVISE",
"arg1_id": "Buprenorphine_ddi_T21",
"arg2_id": "Buprenorphine_ddi_T22",
"normalized": []
},
{
"id": "Buprenorphine_ddi_R5",
"type": "ADVISE",
"arg1_id": "Buprenorphine_ddi_T23",
"arg2_id": "Buprenorphine_ddi_T24",
"normalized": []
},
{
"id": "Buprenorphine_ddi_R6",
"type": "ADVISE",
"arg1_id": "Buprenorphine_ddi_T23",
"arg2_id": "Buprenorphine_ddi_T25",
"normalized": []
}
] |
Colchicine_ddi | Colchicine_ddi | [
{
"id": "Colchicine_ddi__text",
"type": "abstract",
"text": [
"Colchicine is inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents. Colchicine may increase sensitivity to the CNS depressants. Response to sympathomimetic agents may be enhanced by colchicine."
],
"offsets": [
[
0,
235
]
]
}
] | [
{
"id": "Colchicine_ddi_T1",
"type": "DRUG",
"text": [
"Colchicine"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T2",
"type": "GROUP",
"text": [
"acidifying agents"
],
"offsets": [
[
27,
44
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T3",
"type": "DRUG",
"text": [
"colchicine"
],
"offsets": [
[
60,
70
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T4",
"type": "GROUP",
"text": [
"alkalinizing agents"
],
"offsets": [
[
89,
108
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T5",
"type": "DRUG",
"text": [
"Colchicine"
],
"offsets": [
[
110,
120
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T6",
"type": "GROUP",
"text": [
"CNS depressants"
],
"offsets": [
[
153,
168
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T7",
"type": "GROUP",
"text": [
"sympathomimetic agents"
],
"offsets": [
[
182,
204
]
],
"normalized": []
},
{
"id": "Colchicine_ddi_T8",
"type": "DRUG",
"text": [
"colchicine"
],
"offsets": [
[
224,
234
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Colchicine_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Colchicine_ddi_T1",
"arg2_id": "Colchicine_ddi_T2",
"normalized": []
},
{
"id": "Colchicine_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Colchicine_ddi_T3",
"arg2_id": "Colchicine_ddi_T4",
"normalized": []
},
{
"id": "Colchicine_ddi_R3",
"type": "EFFECT",
"arg1_id": "Colchicine_ddi_T5",
"arg2_id": "Colchicine_ddi_T6",
"normalized": []
},
{
"id": "Colchicine_ddi_R4",
"type": "EFFECT",
"arg1_id": "Colchicine_ddi_T7",
"arg2_id": "Colchicine_ddi_T8",
"normalized": []
}
] |
Ertapenem_ddi | Ertapenem_ddi | [
{
"id": "Ertapenem_ddi__text",
"type": "abstract",
"text": [
"When ertapenem is co-administered with probenecid (500 mg p.o. every 6 hours), probenecid competes for active tubular secretion and reduces the renal clearance of ertapenem. Based on total ertapenem concentrations, probenecid increased the AUC by 25% and reduced the plasma and renal clearances by 20% and 35%, respectively. The half-life increased from 4.0 to 4.8 hours. Because of the small effect on half-life, the coadministration with probenecid to extend the half-life of ertapenem is not recommended. In vitro studies indicate that ertapenem does not inhibit P-glycoprotein-mediated transport of digoxin or vinblastine and that ertapenem is not a substrate for P-glycoprotein-mediated transport. In vitro studies in human liver microsomes indicate that ertapenem does not inhibit metabolism mediated by any of the following six cytochrome p450 (CYP) isoforms: 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4. Drug interactions caused by inhibition of P-glycoprotein-mediated drug clearance or CYP-mediated drug clearance with the listed isoforms are unlikely. Other than with probenecid, no specific clinical drug interaction studies have been conducted ."
],
"offsets": [
[
0,
1147
]
]
}
] | [
{
"id": "Ertapenem_ddi_T1",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
5,
14
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T2",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
39,
49
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T3",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
79,
89
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T4",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
163,
172
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T5",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
189,
198
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T6",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
215,
225
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T7",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
440,
450
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T8",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
478,
487
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T9",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
539,
548
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T10",
"type": "DRUG",
"text": [
"digoxin"
],
"offsets": [
[
603,
610
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T11",
"type": "DRUG",
"text": [
"vinblastine"
],
"offsets": [
[
614,
625
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T12",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
635,
644
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T13",
"type": "DRUG",
"text": [
"ertapenem"
],
"offsets": [
[
760,
769
]
],
"normalized": []
},
{
"id": "Ertapenem_ddi_T14",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
1068,
1078
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Ertapenem_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Ertapenem_ddi_T3",
"arg2_id": "Ertapenem_ddi_T4",
"normalized": []
},
{
"id": "Ertapenem_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Ertapenem_ddi_T5",
"arg2_id": "Ertapenem_ddi_T6",
"normalized": []
},
{
"id": "Ertapenem_ddi_R3",
"type": "ADVISE",
"arg1_id": "Ertapenem_ddi_T7",
"arg2_id": "Ertapenem_ddi_T8",
"normalized": []
}
] |
Loracarbef_ddi | Loracarbef_ddi | [
{
"id": "Loracarbef_ddi__text",
"type": "abstract",
"text": [
"Probenecid: As with other b-lactam antibiotics, renal excretion of loracarbef is inhibited by probenecid and resulted in an approximate 80% increase in the AUC for loracarbef."
],
"offsets": [
[
0,
175
]
]
}
] | [
{
"id": "Loracarbef_ddi_T1",
"type": "DRUG",
"text": [
"Probenecid"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "Loracarbef_ddi_T2",
"type": "GROUP",
"text": [
"b-lactam antibiotics"
],
"offsets": [
[
26,
46
]
],
"normalized": []
},
{
"id": "Loracarbef_ddi_T3",
"type": "DRUG",
"text": [
"loracarbef"
],
"offsets": [
[
67,
77
]
],
"normalized": []
},
{
"id": "Loracarbef_ddi_T4",
"type": "DRUG",
"text": [
"probenecid"
],
"offsets": [
[
94,
104
]
],
"normalized": []
},
{
"id": "Loracarbef_ddi_T5",
"type": "DRUG",
"text": [
"loracarbef"
],
"offsets": [
[
164,
174
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Loracarbef_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Loracarbef_ddi_T2",
"arg2_id": "Loracarbef_ddi_T4",
"normalized": []
},
{
"id": "Loracarbef_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Loracarbef_ddi_T3",
"arg2_id": "Loracarbef_ddi_T4",
"normalized": []
}
] |
Entecavir_ddi | Entecavir_ddi | [
{
"id": "Entecavir_ddi__text",
"type": "abstract",
"text": [
"Since entecavir is primarily eliminated by the kidneys, coadministration of BARACLUDE with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug. Coadministration of entecavir with lamivudine, adefovir dipivoxil,or tenofovir disoproxil fumarate did not result in significant drug interactions. The effects of coadministration of BARACLUDE with other drugs that are renally eliminated or are known to affect renal function have not been evaluated, and patients should be monitored closely for adverse events when BARACLUDE is coadministered with such drugs."
],
"offsets": [
[
0,
656
]
]
}
] | [
{
"id": "Entecavir_ddi_T1",
"type": "DRUG",
"text": [
"entecavir"
],
"offsets": [
[
6,
15
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T2",
"type": "BRAND",
"text": [
"BARACLUDE"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T3",
"type": "DRUG",
"text": [
"entecavir"
],
"offsets": [
[
208,
217
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T4",
"type": "DRUG",
"text": [
"entecavir"
],
"offsets": [
[
266,
275
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T5",
"type": "DRUG",
"text": [
"lamivudine"
],
"offsets": [
[
281,
291
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T6",
"type": "DRUG",
"text": [
"adefovir dipivoxil"
],
"offsets": [
[
293,
311
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T7",
"type": "DRUG",
"text": [
"tenofovir disoproxil fumarate"
],
"offsets": [
[
315,
344
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T8",
"type": "BRAND",
"text": [
"BARACLUDE"
],
"offsets": [
[
429,
438
]
],
"normalized": []
},
{
"id": "Entecavir_ddi_T9",
"type": "BRAND",
"text": [
"BARACLUDE"
],
"offsets": [
[
612,
621
]
],
"normalized": []
}
] | [] | [] | [] |
L-Phenylalanine_ddi | L-Phenylalanine_ddi | [
{
"id": "L-Phenylalanine_ddi__text",
"type": "abstract",
"text": [
"Non-selective monoamine oxidase (MAO) inhibitors - including phenelzine sulfate, tranylcypromine sulfate and pargyline HC1. Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension. Selegiline - L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly. Neuroleptic Drugs - L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them."
],
"offsets": [
[
0,
498
]
]
}
] | [
{
"id": "L-Phenylalanine_ddi_T1",
"type": "GROUP",
"text": [
"Non-selective monoamine oxidase (MAO) inhibitors"
],
"offsets": [
[
0,
48
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T2",
"type": "DRUG",
"text": [
"phenelzine sulfate"
],
"offsets": [
[
61,
79
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T3",
"type": "DRUG",
"text": [
"tranylcypromine sulfate"
],
"offsets": [
[
81,
104
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T4",
"type": "DRUG",
"text": [
"pargyline"
],
"offsets": [
[
109,
118
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T5",
"type": "DRUG",
"text": [
"L-phenylalanine"
],
"offsets": [
[
143,
158
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T6",
"type": "GROUP",
"text": [
"non-selective MAO inhibitors"
],
"offsets": [
[
163,
191
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T7",
"type": "DRUG",
"text": [
"Selegiline"
],
"offsets": [
[
216,
226
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T8",
"type": "DRUG",
"text": [
"L-phenylalanine"
],
"offsets": [
[
229,
244
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T9",
"type": "GROUP",
"text": [
"selective MAO inhibitor"
],
"offsets": [
[
253,
276
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T10",
"type": "DRUG",
"text": [
"selegiline"
],
"offsets": [
[
277,
287
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T11",
"type": "GROUP",
"text": [
"Neuroleptic Drugs"
],
"offsets": [
[
356,
373
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T12",
"type": "DRUG",
"text": [
"L-phenylalanine"
],
"offsets": [
[
376,
391
]
],
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_T13",
"type": "GROUP",
"text": [
"neuroleptic drugs"
],
"offsets": [
[
448,
465
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "L-Phenylalanine_ddi_R1",
"type": "EFFECT",
"arg1_id": "L-Phenylalanine_ddi_T5",
"arg2_id": "L-Phenylalanine_ddi_T6",
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_R2",
"type": "EFFECT",
"arg1_id": "L-Phenylalanine_ddi_T8",
"arg2_id": "L-Phenylalanine_ddi_T10",
"normalized": []
},
{
"id": "L-Phenylalanine_ddi_R3",
"type": "EFFECT",
"arg1_id": "L-Phenylalanine_ddi_T11",
"arg2_id": "L-Phenylalanine_ddi_T12",
"normalized": []
}
] |
Caffeine_ddi | Caffeine_ddi | [
{
"id": "Caffeine_ddi__text",
"type": "abstract",
"text": [
"Cytochrome P450 1A2 (CYP1A2) is known to be the major enzyme involved in the metabolism of caffeine. Therefore, caffeine has the potential to interact with drugs that are substrates for CYP1A2, inhibit CYP1A2, or induce CYP1A2. Few data exist on drug interactions with caffeine in preterm neonates. Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin). Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers. The clinical significance of this interaction in preterm neonates is not known. Interconversion between caffeine and theophylline has been reported in preterm neonates. The concurrent use of these drugs is not recommended."
],
"offsets": [
[
0,
953
]
]
}
] | [
{
"id": "Caffeine_ddi_T1",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
91,
99
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T2",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
112,
120
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T3",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
269,
277
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T4",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
335,
343
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T5",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
425,
433
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T6",
"type": "DRUG",
"text": [
"cimetidine"
],
"offsets": [
[
453,
463
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T7",
"type": "DRUG",
"text": [
"ketoconazole"
],
"offsets": [
[
468,
480
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T8",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
493,
501
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T9",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
572,
580
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T10",
"type": "DRUG",
"text": [
"phenobarbital"
],
"offsets": [
[
600,
613
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T11",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
618,
627
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T12",
"type": "DRUG",
"text": [
"Caffeine"
],
"offsets": [
[
630,
638
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T13",
"type": "DRUG",
"text": [
"ketoprofen"
],
"offsets": [
[
670,
680
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T14",
"type": "DRUG",
"text": [
"caffeine"
],
"offsets": [
[
835,
843
]
],
"normalized": []
},
{
"id": "Caffeine_ddi_T15",
"type": "DRUG",
"text": [
"theophylline"
],
"offsets": [
[
848,
860
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Caffeine_ddi_R1",
"type": "ADVISE",
"arg1_id": "Caffeine_ddi_T4",
"arg2_id": "Caffeine_ddi_T6",
"normalized": []
},
{
"id": "Caffeine_ddi_R2",
"type": "ADVISE",
"arg1_id": "Caffeine_ddi_T4",
"arg2_id": "Caffeine_ddi_T7",
"normalized": []
},
{
"id": "Caffeine_ddi_R3",
"type": "ADVISE",
"arg1_id": "Caffeine_ddi_T8",
"arg2_id": "Caffeine_ddi_T10",
"normalized": []
},
{
"id": "Caffeine_ddi_R4",
"type": "ADVISE",
"arg1_id": "Caffeine_ddi_T8",
"arg2_id": "Caffeine_ddi_T11",
"normalized": []
},
{
"id": "Caffeine_ddi_R5",
"type": "EFFECT",
"arg1_id": "Caffeine_ddi_T12",
"arg2_id": "Caffeine_ddi_T13",
"normalized": []
}
] |
Azatadine_ddi | Azatadine_ddi | [
{
"id": "Azatadine_ddi__text",
"type": "abstract",
"text": [
"MAO inhibitors prolong and intensify the effects of antihistamines. Concomitant use of antihistamines with alcohol, tricyclic antidepressants, barbiturates, or other central nervous system depressants may have an additive effect. When sympathomimetic drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive reactions, including hypertensive crises, may occur. The antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics. Beta-adrenergic blocking agents may also interact with sympathomimetics. Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis. Antacids increase the rate of absorption of pseudoephedrine, while kaolin decreases it."
],
"offsets": [
[
0,
779
]
]
}
] | [
{
"id": "Azatadine_ddi_T1",
"type": "GROUP",
"text": [
"MAO inhibitors"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T2",
"type": "GROUP",
"text": [
"antihistamines"
],
"offsets": [
[
52,
66
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T3",
"type": "GROUP",
"text": [
"antihistamines"
],
"offsets": [
[
87,
101
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T4",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
107,
114
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T5",
"type": "GROUP",
"text": [
"tricyclic antidepressants"
],
"offsets": [
[
116,
141
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T6",
"type": "GROUP",
"text": [
"barbiturates"
],
"offsets": [
[
143,
155
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T7",
"type": "GROUP",
"text": [
"central nervous system depressants"
],
"offsets": [
[
166,
200
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T8",
"type": "GROUP",
"text": [
"sympathomimetic drugs"
],
"offsets": [
[
235,
256
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T9",
"type": "GROUP",
"text": [
"monoamine oxidase inhibitors"
],
"offsets": [
[
289,
317
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T10",
"type": "DRUG",
"text": [
"methyldopa"
],
"offsets": [
[
417,
427
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T11",
"type": "DRUG",
"text": [
"mecamylamine"
],
"offsets": [
[
429,
441
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T12",
"type": "DRUG",
"text": [
"reserpine"
],
"offsets": [
[
443,
452
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T13",
"type": "DRUG",
"text": [
"veratrum alkaloids"
],
"offsets": [
[
458,
476
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T14",
"type": "GROUP",
"text": [
"sympathomimetics"
],
"offsets": [
[
495,
511
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T15",
"type": "GROUP",
"text": [
"Beta-adrenergic blocking agents"
],
"offsets": [
[
513,
544
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T16",
"type": "GROUP",
"text": [
"sympathomimetics"
],
"offsets": [
[
568,
584
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T17",
"type": "DRUG",
"text": [
"pseudoephedrine"
],
"offsets": [
[
638,
653
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T18",
"type": "GROUP",
"text": [
"digitalis"
],
"offsets": [
[
681,
690
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T19",
"type": "GROUP",
"text": [
"Antacids"
],
"offsets": [
[
692,
700
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T20",
"type": "DRUG",
"text": [
"pseudoephedrine"
],
"offsets": [
[
736,
751
]
],
"normalized": []
},
{
"id": "Azatadine_ddi_T21",
"type": "DRUG",
"text": [
"kaolin"
],
"offsets": [
[
759,
765
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Azatadine_ddi_R1",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T1",
"arg2_id": "Azatadine_ddi_T2",
"normalized": []
},
{
"id": "Azatadine_ddi_R2",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T3",
"arg2_id": "Azatadine_ddi_T4",
"normalized": []
},
{
"id": "Azatadine_ddi_R3",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T3",
"arg2_id": "Azatadine_ddi_T5",
"normalized": []
},
{
"id": "Azatadine_ddi_R4",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T3",
"arg2_id": "Azatadine_ddi_T6",
"normalized": []
},
{
"id": "Azatadine_ddi_R5",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T3",
"arg2_id": "Azatadine_ddi_T7",
"normalized": []
},
{
"id": "Azatadine_ddi_R6",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T8",
"arg2_id": "Azatadine_ddi_T9",
"normalized": []
},
{
"id": "Azatadine_ddi_R7",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T10",
"arg2_id": "Azatadine_ddi_T14",
"normalized": []
},
{
"id": "Azatadine_ddi_R8",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T11",
"arg2_id": "Azatadine_ddi_T14",
"normalized": []
},
{
"id": "Azatadine_ddi_R9",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T12",
"arg2_id": "Azatadine_ddi_T14",
"normalized": []
},
{
"id": "Azatadine_ddi_R10",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T13",
"arg2_id": "Azatadine_ddi_T14",
"normalized": []
},
{
"id": "Azatadine_ddi_R11",
"type": "INT",
"arg1_id": "Azatadine_ddi_T15",
"arg2_id": "Azatadine_ddi_T16",
"normalized": []
},
{
"id": "Azatadine_ddi_R12",
"type": "EFFECT",
"arg1_id": "Azatadine_ddi_T17",
"arg2_id": "Azatadine_ddi_T18",
"normalized": []
},
{
"id": "Azatadine_ddi_R13",
"type": "MECHANISM",
"arg1_id": "Azatadine_ddi_T19",
"arg2_id": "Azatadine_ddi_T20",
"normalized": []
},
{
"id": "Azatadine_ddi_R14",
"type": "MECHANISM",
"arg1_id": "Azatadine_ddi_T20",
"arg2_id": "Azatadine_ddi_T21",
"normalized": []
}
] |
Allopurinol_ddi | Allopurinol_ddi | [
{
"id": "Allopurinol_ddi__text",
"type": "abstract",
"text": [
"The following drug interactions were observed in some patients undergoing treatment with oral allopurinol. Although the pattern of use for oral allopurinol includes longer term therapy, particularly for gout and renal calculi, the experience gained may be relevant. Mercaptopurine/Azathioprine: Allopurinol inhibits the enzymatic oxidation of mercaptopurine and azathioprine to 6-thiouric acid. This oxidation, which is catalyzed by xanthine oxidase, inactivates mercaptopurine. In patients receiving mercaptopurine (Purinethol) or azathioprine (Imuran), the concomitant administration of 300-600 mg of allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects. Dicumarol: It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol. The clinical basis of this drug interaction has not been established but should be noted when allopurinol is given to patients already on dicumarol therapy. Consequently, prothrombin time should be reassessed periodically in patients receiving both drugs. Uricosuric Agents: Since the excretion of oxipurinol is similar to that of urate, uricosuric agents, which increase the excretion of urate, are also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidase. The concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines (hypoxanthine and xanthine) and an increase in urinary uric acid excretion compared with that observed with allopurinol alone. Although clinical evidence to date has not demonstrated renal precipitation of oxypurines in patients either on allopurinol alone or in combination with uricosuric agents, the possibility should be kept in mind. Thiazide Diuretics: The reports that the concomitant use of allopurinol and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causation. Review of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests to rule out decreased renal function secondary to hypertensive nephropathy were not often performed. In those patients in whom renal insufficiency was documented, however, the recommendation to lower the dose of allopurinol was not followed. Although a causal mechanism and a cause-and-effect relationship have not been established, current evidence suggests that renal function should be monitored in patients on thiazide diuretics and allopurinol even in the absence of renal failure, and dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.. Ampicillin/Amoxicillin: An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs. The cause of the reported association has not been established. Cytotoxic Agents: Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of allopurinol. However, in a well-controlled study of patients with lymphoma on combination therapy, allopurinol did not increase the marrow toxicity of patients treated with cyclophosphamide, doxorubicin, bleomycin, procarbazine and/or mechlorethamine. Chlorpropamide: Chlorpropamides plasma half-life may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in the renal tubule. The risk of hypoglycemia secondary to this mechanism may be increased if allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency. Cyclosporin: Reports indicate that cyclosporine levels may be increased during concomitant treatment with allopurinol sodium for injection. Monitoring of cyclosporine levels and possible adjustment of cyclosporine dosage should be considered when these drugs are co-administered. Tolbutamides conversion to inactive metabolites has been shown to be catalyzed by xanthine oxidase from rat liver. The clinical significance, if any, of these observations is unknown."
],
"offsets": [
[
0,
4564
]
]
}
] | [
{
"id": "Allopurinol_ddi_T1",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
94,
105
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T2",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
144,
155
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T3",
"type": "DRUG",
"text": [
"Mercaptopurine"
],
"offsets": [
[
266,
280
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T4",
"type": "DRUG",
"text": [
"Azathioprine"
],
"offsets": [
[
281,
293
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T5",
"type": "DRUG",
"text": [
"Allopurinol"
],
"offsets": [
[
295,
306
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T6",
"type": "DRUG",
"text": [
"mercaptopurine"
],
"offsets": [
[
343,
357
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T7",
"type": "DRUG",
"text": [
"azathioprine"
],
"offsets": [
[
362,
374
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T8",
"type": "DRUG",
"text": [
"6-thiouric acid"
],
"offsets": [
[
378,
393
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T9",
"type": "DRUG",
"text": [
"mercaptopurine"
],
"offsets": [
[
463,
477
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T10",
"type": "DRUG",
"text": [
"mercaptopurine"
],
"offsets": [
[
501,
515
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T11",
"type": "BRAND",
"text": [
"Purinethol"
],
"offsets": [
[
517,
527
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T12",
"type": "DRUG",
"text": [
"azathioprine"
],
"offsets": [
[
532,
544
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T13",
"type": "BRAND",
"text": [
"Imuran"
],
"offsets": [
[
546,
552
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T14",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
603,
614
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T15",
"type": "DRUG",
"text": [
"mercaptopurine"
],
"offsets": [
[
718,
732
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T16",
"type": "DRUG",
"text": [
"azathioprine"
],
"offsets": [
[
736,
748
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T17",
"type": "DRUG",
"text": [
"mercaptopurine"
],
"offsets": [
[
784,
798
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T18",
"type": "DRUG",
"text": [
"azathioprine"
],
"offsets": [
[
802,
814
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T19",
"type": "DRUG",
"text": [
"Dicumarol"
],
"offsets": [
[
904,
913
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T20",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
941,
952
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T21",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
983,
996
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T22",
"type": "DRUG",
"text": [
"dicumarol"
],
"offsets": [
[
998,
1007
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T23",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
1103,
1114
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T24",
"type": "DRUG",
"text": [
"dicumarol"
],
"offsets": [
[
1147,
1156
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T25",
"type": "GROUP",
"text": [
"Uricosuric Agents"
],
"offsets": [
[
1265,
1282
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T26",
"type": "DRUG",
"text": [
"oxipurinol"
],
"offsets": [
[
1307,
1317
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T27",
"type": "GROUP",
"text": [
"uricosuric agents"
],
"offsets": [
[
1347,
1364
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T28",
"type": "DRUG",
"text": [
"oxipurinol"
],
"offsets": [
[
1450,
1460
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T29",
"type": "GROUP",
"text": [
"uricosuric agents"
],
"offsets": [
[
1556,
1573
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T30",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
1578,
1589
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T31",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
1765,
1776
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T32",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
1896,
1907
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T33",
"type": "GROUP",
"text": [
"uricosuric agents"
],
"offsets": [
[
1937,
1954
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T34",
"type": "GROUP",
"text": [
"Thiazide Diuretics"
],
"offsets": [
[
1996,
2014
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T35",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
2056,
2067
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T36",
"type": "GROUP",
"text": [
"thiazide diuretics"
],
"offsets": [
[
2072,
2090
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T37",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
2128,
2139
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T38",
"type": "GROUP",
"text": [
"thiazide diuretics"
],
"offsets": [
[
2353,
2371
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T39",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
2616,
2627
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T40",
"type": "GROUP",
"text": [
"thiazide diuretics"
],
"offsets": [
[
2818,
2836
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T41",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
2841,
2852
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T42",
"type": "DRUG",
"text": [
"Ampicillin"
],
"offsets": [
[
3039,
3049
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T43",
"type": "DRUG",
"text": [
"Amoxicillin"
],
"offsets": [
[
3050,
3061
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T44",
"type": "DRUG",
"text": [
"ampicillin"
],
"offsets": [
[
3148,
3158
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T45",
"type": "DRUG",
"text": [
"amoxicillin"
],
"offsets": [
[
3162,
3173
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T46",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3192,
3203
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T47",
"type": "GROUP",
"text": [
"Cytotoxic Agents"
],
"offsets": [
[
3323,
3339
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T48",
"type": "DRUG",
"text": [
"cyclophosphamide"
],
"offsets": [
[
3377,
3393
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T49",
"type": "GROUP",
"text": [
"cytotoxic agents"
],
"offsets": [
[
3404,
3420
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T50",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3515,
3526
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T51",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3614,
3625
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T52",
"type": "DRUG",
"text": [
"cyclophosphamide"
],
"offsets": [
[
3688,
3704
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T53",
"type": "DRUG",
"text": [
"doxorubicin"
],
"offsets": [
[
3706,
3717
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T54",
"type": "DRUG",
"text": [
"bleomycin"
],
"offsets": [
[
3719,
3728
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T55",
"type": "DRUG",
"text": [
"procarbazine"
],
"offsets": [
[
3730,
3742
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T56",
"type": "DRUG",
"text": [
"mechlorethamine"
],
"offsets": [
[
3750,
3765
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T57",
"type": "DRUG",
"text": [
"Chlorpropamide"
],
"offsets": [
[
3767,
3781
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T58",
"type": "DRUG",
"text": [
"Chlorpropamide"
],
"offsets": [
[
3783,
3797
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T59",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3836,
3847
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T60",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3855,
3866
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T61",
"type": "DRUG",
"text": [
"chlorpropamide"
],
"offsets": [
[
3871,
3885
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T62",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
4006,
4017
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T63",
"type": "DRUG",
"text": [
"chlorpropamide"
],
"offsets": [
[
4022,
4036
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T64",
"type": "DRUG",
"text": [
"Cyclosporin"
],
"offsets": [
[
4101,
4112
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T65",
"type": "DRUG",
"text": [
"cyclosporine"
],
"offsets": [
[
4136,
4148
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T66",
"type": "DRUG",
"text": [
"allopurinol sodium"
],
"offsets": [
[
4207,
4225
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T67",
"type": "DRUG",
"text": [
"cyclosporine"
],
"offsets": [
[
4255,
4267
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T68",
"type": "DRUG",
"text": [
"cyclosporine"
],
"offsets": [
[
4302,
4314
]
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T69",
"type": "DRUG",
"text": [
"Tolbutamide"
],
"offsets": [
[
4381,
4392
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Allopurinol_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T5",
"arg2_id": "Allopurinol_ddi_T6",
"normalized": []
},
{
"id": "Allopurinol_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T5",
"arg2_id": "Allopurinol_ddi_T7",
"normalized": []
},
{
"id": "Allopurinol_ddi_R3",
"type": "ADVISE",
"arg1_id": "Allopurinol_ddi_T14",
"arg2_id": "Allopurinol_ddi_T15",
"normalized": []
},
{
"id": "Allopurinol_ddi_R4",
"type": "ADVISE",
"arg1_id": "Allopurinol_ddi_T14",
"arg2_id": "Allopurinol_ddi_T16",
"normalized": []
},
{
"id": "Allopurinol_ddi_R5",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T20",
"arg2_id": "Allopurinol_ddi_T22",
"normalized": []
},
{
"id": "Allopurinol_ddi_R6",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T27",
"arg2_id": "Allopurinol_ddi_T28",
"normalized": []
},
{
"id": "Allopurinol_ddi_R7",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T29",
"arg2_id": "Allopurinol_ddi_T30",
"normalized": []
},
{
"id": "Allopurinol_ddi_R8",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T35",
"arg2_id": "Allopurinol_ddi_T36",
"normalized": []
},
{
"id": "Allopurinol_ddi_R9",
"type": "ADVISE",
"arg1_id": "Allopurinol_ddi_T40",
"arg2_id": "Allopurinol_ddi_T41",
"normalized": []
},
{
"id": "Allopurinol_ddi_R10",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T44",
"arg2_id": "Allopurinol_ddi_T46",
"normalized": []
},
{
"id": "Allopurinol_ddi_R11",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T45",
"arg2_id": "Allopurinol_ddi_T46",
"normalized": []
},
{
"id": "Allopurinol_ddi_R12",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T48",
"arg2_id": "Allopurinol_ddi_T50",
"normalized": []
},
{
"id": "Allopurinol_ddi_R13",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T49",
"arg2_id": "Allopurinol_ddi_T50",
"normalized": []
},
{
"id": "Allopurinol_ddi_R14",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T58",
"arg2_id": "Allopurinol_ddi_T59",
"normalized": []
},
{
"id": "Allopurinol_ddi_R15",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T60",
"arg2_id": "Allopurinol_ddi_T61",
"normalized": []
},
{
"id": "Allopurinol_ddi_R16",
"type": "EFFECT",
"arg1_id": "Allopurinol_ddi_T62",
"arg2_id": "Allopurinol_ddi_T63",
"normalized": []
},
{
"id": "Allopurinol_ddi_R17",
"type": "MECHANISM",
"arg1_id": "Allopurinol_ddi_T65",
"arg2_id": "Allopurinol_ddi_T66",
"normalized": []
}
] |
Anisindione_ddi | Anisindione_ddi | [
{
"id": "Anisindione_ddi__text",
"type": "abstract",
"text": [
"Addition or deletion of any drug from the therapeutic regimen of patients receiving oral anticoagulants may affect patient response to the anticoagulant. Frequent determination of prothrombin time and close monitoring of the patient is essential to ascertain when adjustment of dosage of anticoagulant may be needed. Because of the variability of individual patient response, multiple interacting mechanisms with some drugs, the dependency of the extent of the interaction on the dosage and duration of therapy, and the possible administration of several interacting drugs simultaneously, it is difficult to predict the direction and degree of the ultimate effect of concomitant medications on anticoagulant response. For example, since cholestyramine may reduce the gastrointestinal absorption of both the oral anticoagulants and vitamin K, the net effects are unpredictable. Chloral hydrate may cause an increased prothrombin response by displacing the anticoagulant from protein binding sites or a diminished prothrombin response through increased metabolism of the unbound drug by hepatic enzyme induction, thus leading to inter-patient variation in ultimate prothrombin effect. An interacting drug which leads to a decrease in prothrombin time necessitating an increased dose of oral anticoagulant to maintain an adequate degree of anticoagulation may, if abruptly discontinued, increase the risk of subsequent bleeding. Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids; alcohol*; antacids; antihistamines; barbiturates; carbamazepine; chloral hydrate*; chlordiazepoxide; cholestyramine; diet high in vitamin K; diuretics*; ethchlorvynol; glutethimide; griseofulvin; haloperidol; meprobamate; oral contraceptives; paraldehyde; primidone; ranitidine*; rifampin; unreliable prothrombin time determinations; vitamin C; Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;alcohol*;antacids;antihistamines;barbiturates;carbamazepine;chloral hydrate*;chlordiazepoxide;cholestyramine;diet high in vitamin K;diuretics*;ethchlorvynol;glutethimide;griseofulvin;haloperidol;meprobamate;oral contraceptives;paraldehyde;primidone;ranitidine*;rifampin;unreliable prothrombin time determinations;vitamin C;warfarin sodium under-dosage. Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*; allopurinol; aminosalicylic acid; amiodarone; anabolic steroids; antibiotics; bromelains; chloral hydrate*; chlorpropamide; chymotrypsin; cimetidine; cinchophen; clofibrate; dextran; dextrothyroxine; diazoxide; dietary deficiencies; diflunisal; diuretics*; disulfiram; drugs affecting blood elements; ethacrynic acid; fenoprofen; glucagon; hepatotoxic drugs; ibuprofen; indomethacin; influenza virus vaccine; inhalation anesthetics; mefenamic acid; methyldopa; methylphenidate; metronidazole; miconazole; monoamine oxidase inhibitors; nalidixic acid; naproxen; oxolinic acid; oxyphenbutazone; pentoxifylline; phenylbutazone; phenyramidol; phenytoin; prolonged hot weather; prolonged narcotics; pyrazolones; quinidine; quinine; ranitidine*; salicylates;sulfinpyrazone; sulfonamides, long acting; sulindac; thyroid drugs; tolbutamide; triclofos sodium; trimethoprim/sulfamethoxazole; unreliable prothrombin time determinations; Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;allopurinol;aminosalicylic acid;amiodarone;anabolic steroids;antibiotics;bromelains;chloral hydrate*;chlorpropamide;chymotrypsin;cimetidine;cinchophen;clofibrate;dextran;dextrothyroxine;diazoxide;dietary deficiencies;diflunisal;disulfiram;drugs affecting blood elements;ethacrynic acid;fenoprofen;glucagon;hepatotoxic drugs;ibuprofen;indomethacin;influenza virus vaccine;inhalation anesthetics;mefenamic acid;methyldopa;methylphenidate;metronidazole;miconazole;monoamine oxidase inhibitors;nalidixic acid;naproxen;oxolinic acid;oxyphenbutazone;pentoxifylline;phenylbutazone;phenyramidol;phenytoin;prolonged hot weather;prolonged narcotics;pyrazolones;quinidine;quinine;ranitidine*;salicylates;sulfinpyrazone;sulfonamides, long acting;sulindac;thyroid drugs;tolbutamide;triclofos sodium;trimethoprim/sulfamethoxazole;unreliable prothrombin time determinations;warfarin sodium overdosage. Oral anticoagulants may potentiate the hypoglycemic action of hypoglycemic agents, eg, tolbutamide and chlorpropamide, by inhibiting their metabolism in the liver. Because oral anticoagulants may interfere with the hepatic metabolism of phenytoin, toxic levels of the anticonvulsant may occur when an oral anticoagulant and phenytoin are administered concurrently. Drugs that reduce the number of blood platelets by causing bone marrow depression (such as antineoplastic agents) or drugs which inhibit platelet function (eg, aspirin and other non-steroidal anti-inflammatory drugs, dipyridamole, hydrochloroquine, clofibrate, dextran) may increase the bleeding tendency produced by anticoagulants without altering prothrombin time determinations. The beneficial effects on arterial thrombus formation from combined therapy with antiplatelet and anticoagulant medication must be weighed against an increased risk of inducing hemorrhage. *Increased and decreased prothrombin time responses have been reported. Drug/Laboratory Test Interferences: Dicumarol and indanedione anticoagulants, including anisindione, or their metabolites may color alkaline urine red-orange, which may interfere with spectrophotometrically determined urinary laboratory tests. The color reverses when the test sample is acidified in vitro to a pH below 4."
],
"offsets": [
[
0,
5851
]
]
}
] | [
{
"id": "Anisindione_ddi_T1",
"type": "GROUP",
"text": [
"anticoagulants"
],
"offsets": [
[
89,
103
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T2",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
139,
152
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T3",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
288,
301
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T4",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
694,
707
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T5",
"type": "DRUG",
"text": [
"cholestyramine"
],
"offsets": [
[
737,
751
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T6",
"type": "GROUP",
"text": [
"anticoagulants"
],
"offsets": [
[
812,
826
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T7",
"type": "GROUP",
"text": [
"vitamin K"
],
"offsets": [
[
831,
840
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T8",
"type": "DRUG",
"text": [
"Chloral hydrate"
],
"offsets": [
[
877,
892
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T9",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
955,
968
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T10",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
1289,
1302
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T11",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
1473,
1486
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T12",
"type": "GROUP",
"text": [
"adrenocortical steroids"
],
"offsets": [
[
1569,
1592
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T13",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
1594,
1601
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T14",
"type": "GROUP",
"text": [
"antacids"
],
"offsets": [
[
1604,
1612
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T15",
"type": "GROUP",
"text": [
"antihistamines"
],
"offsets": [
[
1614,
1628
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T16",
"type": "GROUP",
"text": [
"barbiturates"
],
"offsets": [
[
1630,
1642
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T17",
"type": "DRUG",
"text": [
"carbamazepine"
],
"offsets": [
[
1644,
1657
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T18",
"type": "DRUG",
"text": [
"chloral hydrate"
],
"offsets": [
[
1659,
1674
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T19",
"type": "DRUG",
"text": [
"chlordiazepoxide"
],
"offsets": [
[
1677,
1693
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T20",
"type": "DRUG",
"text": [
"cholestyramine"
],
"offsets": [
[
1695,
1709
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T21",
"type": "GROUP",
"text": [
"vitamin K"
],
"offsets": [
[
1724,
1733
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T22",
"type": "GROUP",
"text": [
"diuretics"
],
"offsets": [
[
1735,
1744
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T23",
"type": "DRUG",
"text": [
"ethchlorvynol"
],
"offsets": [
[
1747,
1760
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T24",
"type": "DRUG",
"text": [
"glutethimide"
],
"offsets": [
[
1762,
1774
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T25",
"type": "DRUG",
"text": [
"griseofulvin"
],
"offsets": [
[
1776,
1788
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T26",
"type": "DRUG",
"text": [
"haloperidol"
],
"offsets": [
[
1790,
1801
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T27",
"type": "DRUG",
"text": [
"meprobamate"
],
"offsets": [
[
1803,
1814
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T28",
"type": "GROUP",
"text": [
"contraceptives"
],
"offsets": [
[
1821,
1835
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T29",
"type": "DRUG",
"text": [
"paraldehyde"
],
"offsets": [
[
1837,
1848
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T30",
"type": "DRUG",
"text": [
"primidone"
],
"offsets": [
[
1850,
1859
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T31",
"type": "DRUG",
"text": [
"ranitidine"
],
"offsets": [
[
1861,
1871
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T32",
"type": "DRUG",
"text": [
"rifampin"
],
"offsets": [
[
1874,
1882
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T33",
"type": "DRUG",
"text": [
"vitamin C"
],
"offsets": [
[
1928,
1937
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T34",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
1986,
1999
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T35",
"type": "GROUP",
"text": [
"adrenocortical steroids"
],
"offsets": [
[
2082,
2105
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T36",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
2106,
2113
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T37",
"type": "GROUP",
"text": [
"antacids"
],
"offsets": [
[
2115,
2123
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T38",
"type": "GROUP",
"text": [
"antihistamines"
],
"offsets": [
[
2124,
2138
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T39",
"type": "GROUP",
"text": [
"barbiturates"
],
"offsets": [
[
2139,
2151
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T40",
"type": "DRUG",
"text": [
"carbamazepine"
],
"offsets": [
[
2152,
2165
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T41",
"type": "DRUG",
"text": [
"chloral hydrate"
],
"offsets": [
[
2166,
2181
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T42",
"type": "DRUG",
"text": [
"chlordiazepoxide"
],
"offsets": [
[
2183,
2199
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T43",
"type": "DRUG",
"text": [
"cholestyramine"
],
"offsets": [
[
2200,
2214
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T44",
"type": "GROUP",
"text": [
"vitamin K"
],
"offsets": [
[
2228,
2237
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T45",
"type": "GROUP",
"text": [
"diuretics"
],
"offsets": [
[
2238,
2247
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T46",
"type": "DRUG",
"text": [
"ethchlorvynol"
],
"offsets": [
[
2249,
2262
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T47",
"type": "DRUG",
"text": [
"glutethimide"
],
"offsets": [
[
2263,
2275
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T48",
"type": "DRUG",
"text": [
"griseofulvin"
],
"offsets": [
[
2276,
2288
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T49",
"type": "DRUG",
"text": [
"haloperidol"
],
"offsets": [
[
2289,
2300
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T50",
"type": "DRUG",
"text": [
"meprobamate"
],
"offsets": [
[
2301,
2312
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T51",
"type": "GROUP",
"text": [
"contraceptives"
],
"offsets": [
[
2318,
2332
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T52",
"type": "DRUG",
"text": [
"paraldehyde"
],
"offsets": [
[
2333,
2344
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T53",
"type": "DRUG",
"text": [
"primidone"
],
"offsets": [
[
2345,
2354
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T54",
"type": "DRUG",
"text": [
"ranitidine"
],
"offsets": [
[
2355,
2365
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T55",
"type": "DRUG",
"text": [
"rifampin"
],
"offsets": [
[
2367,
2375
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T56",
"type": "DRUG",
"text": [
"vitamin C"
],
"offsets": [
[
2419,
2428
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T57",
"type": "DRUG",
"text": [
"warfarin sodium"
],
"offsets": [
[
2429,
2444
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T58",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
2499,
2512
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T59",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
2574,
2581
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T60",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
2584,
2595
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T61",
"type": "DRUG",
"text": [
"aminosalicylic acid"
],
"offsets": [
[
2597,
2616
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T62",
"type": "DRUG",
"text": [
"amiodarone"
],
"offsets": [
[
2618,
2628
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T63",
"type": "GROUP",
"text": [
"anabolic steroids"
],
"offsets": [
[
2630,
2647
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T64",
"type": "GROUP",
"text": [
"antibiotics"
],
"offsets": [
[
2649,
2660
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T65",
"type": "DRUG",
"text": [
"bromelains"
],
"offsets": [
[
2662,
2672
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T66",
"type": "DRUG",
"text": [
"chloral hydrate"
],
"offsets": [
[
2674,
2689
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T67",
"type": "DRUG",
"text": [
"chlorpropamide"
],
"offsets": [
[
2692,
2706
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T68",
"type": "DRUG",
"text": [
"chymotrypsin"
],
"offsets": [
[
2708,
2720
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T69",
"type": "DRUG",
"text": [
"cimetidine"
],
"offsets": [
[
2722,
2732
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T70",
"type": "DRUG",
"text": [
"cinchophen"
],
"offsets": [
[
2734,
2744
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T71",
"type": "DRUG",
"text": [
"clofibrate"
],
"offsets": [
[
2746,
2756
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T72",
"type": "DRUG",
"text": [
"dextran"
],
"offsets": [
[
2758,
2765
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T73",
"type": "DRUG",
"text": [
"dextrothyroxine"
],
"offsets": [
[
2767,
2782
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T74",
"type": "DRUG",
"text": [
"diazoxide"
],
"offsets": [
[
2784,
2793
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T75",
"type": "DRUG",
"text": [
"diflunisal"
],
"offsets": [
[
2817,
2827
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T76",
"type": "GROUP",
"text": [
"diuretics"
],
"offsets": [
[
2829,
2838
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T77",
"type": "DRUG",
"text": [
"disulfiram"
],
"offsets": [
[
2841,
2851
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T78",
"type": "DRUG",
"text": [
"ethacrynic acid"
],
"offsets": [
[
2885,
2900
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T79",
"type": "DRUG",
"text": [
"fenoprofen"
],
"offsets": [
[
2902,
2912
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T80",
"type": "DRUG",
"text": [
"glucagon"
],
"offsets": [
[
2914,
2922
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T81",
"type": "DRUG",
"text": [
"ibuprofen"
],
"offsets": [
[
2943,
2952
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T82",
"type": "DRUG",
"text": [
"indomethacin"
],
"offsets": [
[
2954,
2966
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T83",
"type": "GROUP",
"text": [
"influenza virus vaccine"
],
"offsets": [
[
2968,
2991
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T84",
"type": "GROUP",
"text": [
"anesthetics"
],
"offsets": [
[
3004,
3015
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T85",
"type": "DRUG",
"text": [
"mefenamic acid"
],
"offsets": [
[
3017,
3031
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T86",
"type": "DRUG",
"text": [
"methyldopa"
],
"offsets": [
[
3033,
3043
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T87",
"type": "DRUG",
"text": [
"methylphenidate"
],
"offsets": [
[
3045,
3060
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T88",
"type": "DRUG",
"text": [
"metronidazole"
],
"offsets": [
[
3062,
3075
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T89",
"type": "DRUG",
"text": [
"miconazole"
],
"offsets": [
[
3077,
3087
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T90",
"type": "GROUP",
"text": [
"monoamine oxidase inhibitors"
],
"offsets": [
[
3089,
3117
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T91",
"type": "DRUG",
"text": [
"nalidixic acid"
],
"offsets": [
[
3119,
3133
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T92",
"type": "DRUG",
"text": [
"naproxen"
],
"offsets": [
[
3135,
3143
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T93",
"type": "DRUG",
"text": [
"oxolinic acid"
],
"offsets": [
[
3145,
3158
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T94",
"type": "DRUG",
"text": [
"oxyphenbutazone"
],
"offsets": [
[
3160,
3175
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T95",
"type": "DRUG",
"text": [
"pentoxifylline"
],
"offsets": [
[
3177,
3191
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T96",
"type": "DRUG",
"text": [
"phenylbutazone"
],
"offsets": [
[
3193,
3207
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T97",
"type": "DRUG_N",
"text": [
"phenyramidol"
],
"offsets": [
[
3209,
3221
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T98",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
3223,
3232
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T99",
"type": "GROUP",
"text": [
"prolonged narcotics"
],
"offsets": [
[
3257,
3276
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T100",
"type": "GROUP",
"text": [
"pyrazolones"
],
"offsets": [
[
3278,
3289
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T101",
"type": "DRUG",
"text": [
"quinidine"
],
"offsets": [
[
3291,
3300
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T102",
"type": "DRUG",
"text": [
"quinine"
],
"offsets": [
[
3302,
3309
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T103",
"type": "DRUG",
"text": [
"ranitidine"
],
"offsets": [
[
3311,
3321
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T104",
"type": "GROUP",
"text": [
"salicylates"
],
"offsets": [
[
3324,
3335
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T105",
"type": "DRUG",
"text": [
"sulfinpyrazone"
],
"offsets": [
[
3336,
3350
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T106",
"type": "GROUP",
"text": [
"sulfonamides"
],
"offsets": [
[
3352,
3364
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T107",
"type": "DRUG",
"text": [
"sulindac"
],
"offsets": [
[
3379,
3387
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T108",
"type": "GROUP",
"text": [
"thyroid drugs"
],
"offsets": [
[
3389,
3402
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T109",
"type": "DRUG",
"text": [
"tolbutamide"
],
"offsets": [
[
3404,
3415
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T110",
"type": "DRUG",
"text": [
"triclofos sodium"
],
"offsets": [
[
3417,
3433
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T111",
"type": "DRUG",
"text": [
"trimethoprim"
],
"offsets": [
[
3435,
3447
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T112",
"type": "DRUG",
"text": [
"sulfamethoxazole"
],
"offsets": [
[
3448,
3464
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T113",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
3550,
3563
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T114",
"type": "DRUG",
"text": [
"alcohol"
],
"offsets": [
[
3625,
3632
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T115",
"type": "DRUG",
"text": [
"allopurinol"
],
"offsets": [
[
3634,
3645
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T116",
"type": "DRUG",
"text": [
"aminosalicylic acid"
],
"offsets": [
[
3646,
3665
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T117",
"type": "DRUG",
"text": [
"amiodarone"
],
"offsets": [
[
3666,
3676
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T118",
"type": "GROUP",
"text": [
"anabolic steroids"
],
"offsets": [
[
3677,
3694
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T119",
"type": "GROUP",
"text": [
"antibiotics"
],
"offsets": [
[
3695,
3706
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T120",
"type": "DRUG",
"text": [
"bromelains"
],
"offsets": [
[
3707,
3717
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T121",
"type": "DRUG",
"text": [
"chloral hydrate"
],
"offsets": [
[
3718,
3733
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T122",
"type": "DRUG",
"text": [
"chlorpropamide"
],
"offsets": [
[
3735,
3749
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T123",
"type": "DRUG",
"text": [
"chymotrypsin"
],
"offsets": [
[
3750,
3762
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T124",
"type": "DRUG",
"text": [
"cimetidine"
],
"offsets": [
[
3763,
3773
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T125",
"type": "DRUG",
"text": [
"cinchophen"
],
"offsets": [
[
3774,
3784
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T126",
"type": "DRUG",
"text": [
"clofibrate"
],
"offsets": [
[
3785,
3795
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T127",
"type": "DRUG",
"text": [
"dextran"
],
"offsets": [
[
3796,
3803
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T128",
"type": "DRUG",
"text": [
"dextrothyroxine"
],
"offsets": [
[
3804,
3819
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T129",
"type": "DRUG",
"text": [
"diazoxide"
],
"offsets": [
[
3820,
3829
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T130",
"type": "DRUG",
"text": [
"diflunisal"
],
"offsets": [
[
3851,
3861
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T131",
"type": "DRUG",
"text": [
"disulfiram"
],
"offsets": [
[
3862,
3872
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T132",
"type": "DRUG",
"text": [
"ethacrynic acid"
],
"offsets": [
[
3904,
3919
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T133",
"type": "DRUG",
"text": [
"fenoprofen"
],
"offsets": [
[
3920,
3930
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T134",
"type": "DRUG",
"text": [
"glucagon"
],
"offsets": [
[
3931,
3939
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T135",
"type": "DRUG",
"text": [
"ibuprofen"
],
"offsets": [
[
3958,
3967
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T136",
"type": "DRUG",
"text": [
"indomethacin"
],
"offsets": [
[
3968,
3980
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T137",
"type": "GROUP",
"text": [
"influenza virus vaccine"
],
"offsets": [
[
3981,
4004
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T138",
"type": "GROUP",
"text": [
"anesthetics"
],
"offsets": [
[
4016,
4027
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T139",
"type": "DRUG",
"text": [
"mefenamic acid"
],
"offsets": [
[
4028,
4042
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T140",
"type": "DRUG",
"text": [
"methyldopa"
],
"offsets": [
[
4043,
4053
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T141",
"type": "DRUG",
"text": [
"methylphenidate"
],
"offsets": [
[
4054,
4069
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T142",
"type": "DRUG",
"text": [
"metronidazole"
],
"offsets": [
[
4070,
4083
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T143",
"type": "DRUG",
"text": [
"miconazole"
],
"offsets": [
[
4084,
4094
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T144",
"type": "GROUP",
"text": [
"monoamine oxidase inhibitors"
],
"offsets": [
[
4095,
4123
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T145",
"type": "DRUG",
"text": [
"nalidixic acid"
],
"offsets": [
[
4124,
4138
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T146",
"type": "DRUG",
"text": [
"naproxen"
],
"offsets": [
[
4139,
4147
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T147",
"type": "DRUG",
"text": [
"oxolinic acid"
],
"offsets": [
[
4148,
4161
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T148",
"type": "DRUG",
"text": [
"oxyphenbutazone"
],
"offsets": [
[
4162,
4177
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T149",
"type": "DRUG",
"text": [
"pentoxifylline"
],
"offsets": [
[
4178,
4192
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T150",
"type": "DRUG",
"text": [
"phenylbutazone"
],
"offsets": [
[
4193,
4207
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T151",
"type": "DRUG_N",
"text": [
"phenyramidol"
],
"offsets": [
[
4208,
4220
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T152",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
4221,
4230
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T153",
"type": "GROUP",
"text": [
"prolonged narcotics"
],
"offsets": [
[
4253,
4272
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T154",
"type": "GROUP",
"text": [
"pyrazolones"
],
"offsets": [
[
4273,
4284
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T155",
"type": "DRUG",
"text": [
"quinidine"
],
"offsets": [
[
4285,
4294
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T156",
"type": "DRUG",
"text": [
"quinine"
],
"offsets": [
[
4295,
4302
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T157",
"type": "DRUG",
"text": [
"ranitidine"
],
"offsets": [
[
4303,
4313
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T158",
"type": "GROUP",
"text": [
"salicylates"
],
"offsets": [
[
4315,
4326
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T159",
"type": "DRUG",
"text": [
"sulfinpyrazone"
],
"offsets": [
[
4327,
4341
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T160",
"type": "GROUP",
"text": [
"sulfonamides"
],
"offsets": [
[
4342,
4354
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T161",
"type": "DRUG",
"text": [
"sulindac"
],
"offsets": [
[
4368,
4376
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T162",
"type": "GROUP",
"text": [
"thyroid drugs"
],
"offsets": [
[
4377,
4390
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T163",
"type": "DRUG",
"text": [
"tolbutamide"
],
"offsets": [
[
4391,
4402
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T164",
"type": "DRUG",
"text": [
"triclofos sodium"
],
"offsets": [
[
4403,
4419
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T165",
"type": "DRUG",
"text": [
"trimethoprim"
],
"offsets": [
[
4420,
4432
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T166",
"type": "DRUG",
"text": [
"sulfamethoxazole"
],
"offsets": [
[
4433,
4449
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T167",
"type": "DRUG",
"text": [
"warfarin sodium"
],
"offsets": [
[
4493,
4508
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T168",
"type": "GROUP",
"text": [
"anticoagulants"
],
"offsets": [
[
4526,
4540
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T169",
"type": "GROUP",
"text": [
"hypoglycemic agents"
],
"offsets": [
[
4583,
4602
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T170",
"type": "DRUG",
"text": [
"tolbutamide"
],
"offsets": [
[
4608,
4619
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T171",
"type": "DRUG",
"text": [
"chlorpropamide"
],
"offsets": [
[
4624,
4638
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T172",
"type": "GROUP",
"text": [
"anticoagulants"
],
"offsets": [
[
4698,
4712
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T173",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
4758,
4767
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T174",
"type": "GROUP",
"text": [
"anticonvulsant"
],
"offsets": [
[
4789,
4803
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T175",
"type": "GROUP",
"text": [
"anticoagulant"
],
"offsets": [
[
4827,
4840
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T176",
"type": "DRUG",
"text": [
"phenytoin"
],
"offsets": [
[
4845,
4854
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T177",
"type": "GROUP",
"text": [
"antineoplastic agents"
],
"offsets": [
[
4977,
4998
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T178",
"type": "BRAND",
"text": [
"aspirin"
],
"offsets": [
[
5046,
5053
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T179",
"type": "GROUP",
"text": [
"non-steroidal anti-inflammatory drugs"
],
"offsets": [
[
5064,
5101
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T180",
"type": "DRUG",
"text": [
"dipyridamole"
],
"offsets": [
[
5103,
5115
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T181",
"type": "DRUG",
"text": [
"hydrochloroquine"
],
"offsets": [
[
5117,
5133
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T182",
"type": "DRUG",
"text": [
"clofibrate"
],
"offsets": [
[
5135,
5145
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T183",
"type": "DRUG",
"text": [
"dextran"
],
"offsets": [
[
5147,
5154
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T184",
"type": "GROUP",
"text": [
"anticoagulants"
],
"offsets": [
[
5203,
5217
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T185",
"type": "GROUP",
"text": [
"antiplatelet",
"medication"
],
"offsets": [
[
5349,
5361
],
[
5380,
5390
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T186",
"type": "GROUP",
"text": [
"anticoagulant medication"
],
"offsets": [
[
5366,
5390
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T187",
"type": "DRUG",
"text": [
"Dicumarol"
],
"offsets": [
[
5565,
5574
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T188",
"type": "GROUP",
"text": [
"indanedione anticoagulants"
],
"offsets": [
[
5579,
5605
]
],
"normalized": []
},
{
"id": "Anisindione_ddi_T189",
"type": "DRUG",
"text": [
"anisindione"
],
"offsets": [
[
5617,
5628
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Anisindione_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T5",
"arg2_id": "Anisindione_ddi_T6",
"normalized": []
},
{
"id": "Anisindione_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T5",
"arg2_id": "Anisindione_ddi_T7",
"normalized": []
},
{
"id": "Anisindione_ddi_R3",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T8",
"arg2_id": "Anisindione_ddi_T9",
"normalized": []
},
{
"id": "Anisindione_ddi_R4",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T11",
"arg2_id": "Anisindione_ddi_T12",
"normalized": []
},
{
"id": "Anisindione_ddi_R5",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T35",
"normalized": []
},
{
"id": "Anisindione_ddi_R6",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T36",
"normalized": []
},
{
"id": "Anisindione_ddi_R7",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T37",
"normalized": []
},
{
"id": "Anisindione_ddi_R8",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T38",
"normalized": []
},
{
"id": "Anisindione_ddi_R9",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T39",
"normalized": []
},
{
"id": "Anisindione_ddi_R10",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T40",
"normalized": []
},
{
"id": "Anisindione_ddi_R11",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T41",
"normalized": []
},
{
"id": "Anisindione_ddi_R12",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T42",
"normalized": []
},
{
"id": "Anisindione_ddi_R13",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T43",
"normalized": []
},
{
"id": "Anisindione_ddi_R14",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T44",
"normalized": []
},
{
"id": "Anisindione_ddi_R15",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T45",
"normalized": []
},
{
"id": "Anisindione_ddi_R16",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T46",
"normalized": []
},
{
"id": "Anisindione_ddi_R17",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T47",
"normalized": []
},
{
"id": "Anisindione_ddi_R18",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T48",
"normalized": []
},
{
"id": "Anisindione_ddi_R19",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T49",
"normalized": []
},
{
"id": "Anisindione_ddi_R20",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T50",
"normalized": []
},
{
"id": "Anisindione_ddi_R21",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T51",
"normalized": []
},
{
"id": "Anisindione_ddi_R22",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T52",
"normalized": []
},
{
"id": "Anisindione_ddi_R23",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T53",
"normalized": []
},
{
"id": "Anisindione_ddi_R24",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T54",
"normalized": []
},
{
"id": "Anisindione_ddi_R25",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T55",
"normalized": []
},
{
"id": "Anisindione_ddi_R26",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T56",
"normalized": []
},
{
"id": "Anisindione_ddi_R27",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T34",
"arg2_id": "Anisindione_ddi_T57",
"normalized": []
},
{
"id": "Anisindione_ddi_R28",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T58",
"arg2_id": "Anisindione_ddi_T59",
"normalized": []
},
{
"id": "Anisindione_ddi_R29",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T114",
"normalized": []
},
{
"id": "Anisindione_ddi_R30",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T115",
"normalized": []
},
{
"id": "Anisindione_ddi_R31",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T116",
"normalized": []
},
{
"id": "Anisindione_ddi_R32",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T117",
"normalized": []
},
{
"id": "Anisindione_ddi_R33",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T118",
"normalized": []
},
{
"id": "Anisindione_ddi_R34",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T119",
"normalized": []
},
{
"id": "Anisindione_ddi_R35",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T120",
"normalized": []
},
{
"id": "Anisindione_ddi_R36",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T121",
"normalized": []
},
{
"id": "Anisindione_ddi_R37",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T122",
"normalized": []
},
{
"id": "Anisindione_ddi_R38",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T123",
"normalized": []
},
{
"id": "Anisindione_ddi_R39",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T124",
"normalized": []
},
{
"id": "Anisindione_ddi_R40",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T125",
"normalized": []
},
{
"id": "Anisindione_ddi_R41",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T126",
"normalized": []
},
{
"id": "Anisindione_ddi_R42",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T127",
"normalized": []
},
{
"id": "Anisindione_ddi_R43",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T128",
"normalized": []
},
{
"id": "Anisindione_ddi_R44",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T129",
"normalized": []
},
{
"id": "Anisindione_ddi_R45",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T130",
"normalized": []
},
{
"id": "Anisindione_ddi_R46",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T131",
"normalized": []
},
{
"id": "Anisindione_ddi_R47",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T132",
"normalized": []
},
{
"id": "Anisindione_ddi_R48",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T133",
"normalized": []
},
{
"id": "Anisindione_ddi_R49",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T134",
"normalized": []
},
{
"id": "Anisindione_ddi_R50",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T135",
"normalized": []
},
{
"id": "Anisindione_ddi_R51",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T136",
"normalized": []
},
{
"id": "Anisindione_ddi_R52",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T137",
"normalized": []
},
{
"id": "Anisindione_ddi_R53",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T138",
"normalized": []
},
{
"id": "Anisindione_ddi_R54",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T139",
"normalized": []
},
{
"id": "Anisindione_ddi_R55",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T140",
"normalized": []
},
{
"id": "Anisindione_ddi_R56",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T141",
"normalized": []
},
{
"id": "Anisindione_ddi_R57",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T142",
"normalized": []
},
{
"id": "Anisindione_ddi_R58",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T143",
"normalized": []
},
{
"id": "Anisindione_ddi_R59",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T144",
"normalized": []
},
{
"id": "Anisindione_ddi_R60",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T145",
"normalized": []
},
{
"id": "Anisindione_ddi_R61",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T146",
"normalized": []
},
{
"id": "Anisindione_ddi_R62",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T147",
"normalized": []
},
{
"id": "Anisindione_ddi_R63",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T148",
"normalized": []
},
{
"id": "Anisindione_ddi_R64",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T149",
"normalized": []
},
{
"id": "Anisindione_ddi_R65",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T150",
"normalized": []
},
{
"id": "Anisindione_ddi_R66",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T151",
"normalized": []
},
{
"id": "Anisindione_ddi_R67",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T152",
"normalized": []
},
{
"id": "Anisindione_ddi_R68",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T153",
"normalized": []
},
{
"id": "Anisindione_ddi_R69",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T154",
"normalized": []
},
{
"id": "Anisindione_ddi_R70",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T155",
"normalized": []
},
{
"id": "Anisindione_ddi_R71",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T156",
"normalized": []
},
{
"id": "Anisindione_ddi_R72",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T157",
"normalized": []
},
{
"id": "Anisindione_ddi_R73",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T158",
"normalized": []
},
{
"id": "Anisindione_ddi_R74",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T159",
"normalized": []
},
{
"id": "Anisindione_ddi_R75",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T160",
"normalized": []
},
{
"id": "Anisindione_ddi_R76",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T161",
"normalized": []
},
{
"id": "Anisindione_ddi_R77",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T162",
"normalized": []
},
{
"id": "Anisindione_ddi_R78",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T163",
"normalized": []
},
{
"id": "Anisindione_ddi_R79",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T164",
"normalized": []
},
{
"id": "Anisindione_ddi_R80",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T165",
"normalized": []
},
{
"id": "Anisindione_ddi_R81",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T166",
"normalized": []
},
{
"id": "Anisindione_ddi_R82",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T113",
"arg2_id": "Anisindione_ddi_T167",
"normalized": []
},
{
"id": "Anisindione_ddi_R83",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T168",
"arg2_id": "Anisindione_ddi_T169",
"normalized": []
},
{
"id": "Anisindione_ddi_R84",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T168",
"arg2_id": "Anisindione_ddi_T170",
"normalized": []
},
{
"id": "Anisindione_ddi_R85",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T168",
"arg2_id": "Anisindione_ddi_T171",
"normalized": []
},
{
"id": "Anisindione_ddi_R86",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T172",
"arg2_id": "Anisindione_ddi_T173",
"normalized": []
},
{
"id": "Anisindione_ddi_R87",
"type": "MECHANISM",
"arg1_id": "Anisindione_ddi_T175",
"arg2_id": "Anisindione_ddi_T176",
"normalized": []
},
{
"id": "Anisindione_ddi_R88",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T177",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R89",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T178",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R90",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T179",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R91",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T180",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R92",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T181",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R93",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T182",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R94",
"type": "EFFECT",
"arg1_id": "Anisindione_ddi_T183",
"arg2_id": "Anisindione_ddi_T184",
"normalized": []
},
{
"id": "Anisindione_ddi_R95",
"type": "ADVISE",
"arg1_id": "Anisindione_ddi_T185",
"arg2_id": "Anisindione_ddi_T186",
"normalized": []
}
] |
Albendazole_ddi | Albendazole_ddi | [
{
"id": "Albendazole_ddi__text",
"type": "abstract",
"text": [
"Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in eight neurocysticercosis patients. Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albendazole alone. Mean T max and mean plasma elimination half-life of albendazole sulfoxide were unchanged. The pharmacokinetics of praziquantel were unchanged following coadministration with albendazole (400 mg). Cimetidine: Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n=7) compared with albendazole (20 mg/kg/day) alone (n=12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing. Theophylline: The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects."
],
"offsets": [
[
0,
1184
]
]
}
] | [
{
"id": "Albendazole_ddi_T1",
"type": "DRUG",
"text": [
"Dexamethasone"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T2",
"type": "DRUG",
"text": [
"albendazole sulfoxide"
],
"offsets": [
[
53,
74
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T3",
"type": "DRUG",
"text": [
"dexamethasone"
],
"offsets": [
[
107,
120
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T4",
"type": "DRUG",
"text": [
"albendazole"
],
"offsets": [
[
158,
169
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T5",
"type": "DRUG",
"text": [
"Praziquantel"
],
"offsets": [
[
223,
235
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T6",
"type": "DRUG",
"text": [
"praziquantel"
],
"offsets": [
[
255,
267
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T7",
"type": "DRUG",
"text": [
"albendazole sulfoxide"
],
"offsets": [
[
351,
372
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T8",
"type": "DRUG",
"text": [
"albendazole"
],
"offsets": [
[
468,
479
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T9",
"type": "DRUG",
"text": [
"albendazole sulfoxide"
],
"offsets": [
[
539,
560
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T10",
"type": "DRUG",
"text": [
"praziquantel"
],
"offsets": [
[
601,
613
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T11",
"type": "DRUG",
"text": [
"albendazole"
],
"offsets": [
[
661,
672
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T12",
"type": "DRUG",
"text": [
"Cimetidine"
],
"offsets": [
[
683,
693
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T13",
"type": "DRUG",
"text": [
"Albendazole sulfoxide"
],
"offsets": [
[
695,
716
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T14",
"type": "DRUG",
"text": [
"cimetidine"
],
"offsets": [
[
825,
835
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T15",
"type": "DRUG",
"text": [
"albendazole"
],
"offsets": [
[
871,
882
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T16",
"type": "DRUG",
"text": [
"Albendazole sulfoxide"
],
"offsets": [
[
912,
933
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T17",
"type": "DRUG",
"text": [
"Theophylline"
],
"offsets": [
[
993,
1005
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T18",
"type": "DRUG",
"text": [
"theophylline"
],
"offsets": [
[
1031,
1043
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T19",
"type": "DRUG",
"text": [
"aminophylline"
],
"offsets": [
[
1045,
1058
]
],
"normalized": []
},
{
"id": "Albendazole_ddi_T20",
"type": "DRUG",
"text": [
"albendazole"
],
"offsets": [
[
1141,
1152
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "Albendazole_ddi_R1",
"type": "MECHANISM",
"arg1_id": "Albendazole_ddi_T3",
"arg2_id": "Albendazole_ddi_T4",
"normalized": []
},
{
"id": "Albendazole_ddi_R2",
"type": "MECHANISM",
"arg1_id": "Albendazole_ddi_T6",
"arg2_id": "Albendazole_ddi_T7",
"normalized": []
},
{
"id": "Albendazole_ddi_R3",
"type": "MECHANISM",
"arg1_id": "Albendazole_ddi_T13",
"arg2_id": "Albendazole_ddi_T14",
"normalized": []
}
] |