baber/WOPTO huggingface dataset:
Patent SG-11201900480Y-A (SG)
Title: Anti-tim-3 antibodies
Inventor: CARPENITO CARMINE
IPC: C07K16/28
Filed: 2017-08-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) Hu omits I iolo MEN! 010 110 1110 HOED (10) International Publication Number WO 2018/039020 Al WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61P 35/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2017/047261 (22) International Filing Date: 17 August 2017 (17.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/379,343 25 August 2016 (25.08.2016) US 62/469,753 10 March 2017 (10.03.2017) US (71) Applicant: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, Indiana 46285 (US). (72) Inventors: CARPENITO, Carmine; c/o Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). LI, Yiwen; c/o Eli Lilly and Compa- ny, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). SHEN, Yang; c/o Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). ZHANG, Yi; c/o Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indi- ana 46206-6288 (US). (74) Agent: GARCIA, Carlos et al.; Eli Lilly and Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, O KM, ML, MR, NE, SN, TD, TG). O O Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 00 (54) Title: ANTI-TIM-3 ANTIBODIES 1-1 0 (57) : The present disclosure relates to antibodies that bind human T-cell immunoglobulin- and mucin-domain-containing \" protein-3 (Tim-3), and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and 0 ionizing radiation.
Patent SG-11201903138V-A (SG)
Title: Drainage system
Inventor: WALLIS SIMON
IPC: E03F1/00
Filed: 2017-10-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 11111111110111110 1 0 011101 111111101110111111 101111110 111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/068095 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: (74) Agent: IP SENTINELS PATENT AND TRADEMARK E03F 5/046 (2006.01) E03F 1/00 (2006.01) ATTORNEYS; PO Box 1006, Bentley DC, Western Aus- E01C 11/22 (2006.01) E03F 5/04 (2006.01) tralia 6983 (AU). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/AU2017/051108 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 13 October 2017 (13.10.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 2016904161 13 October 2016 (13.10.2016) AU SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: INFRASTRUCTURE MANAGEMENT SERVICES PTY LTD [AU/AU]; 11 Mahlberg Ave, (84) Designated States (unless otherwise indicated, for every Woodlands, Western Australia 6018 (AU). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: WALLIS, Simon; 11 Mahlberg Ave, Wood-UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, lands, Western Australia 6018 (AU). RICHARDS, Owen; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 11 Mahlberg Ave, Woodlands, Western Australia 6018 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (AU). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = = (54) Title: DRAINAGE SYSTEM = = 14— B — 12 18 = 22 16 12A = 40 = = 40 44 26 10 = / = _ 14 = = 42 24 26 = = 46 30 cE — Il in 32 0\ 0 28 GC Figure 2 0 --.... I l (57) : A drainage system comprises a filter portion and a drainage cell portion. The filter portion is arranged to filter stormwater 0 that ei in turn flows under gravity to the drainage cell portion. The filter portion is able to receive stormwater runoff from a paved surface. o [Continued on next page] WO 2018/068095 Al MIDEDIM011010EIRDERI1111111111111111111111011111111111111111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Patent SG-11201906968Y-A (SG)
Title: Prophylactic and/or therapeutic agent of infectious disease or inflammatory disease
Inventor: SUZUKI KAZUO
IPC: A61P31/00
Filed: 2018-01-26
Abstract: PROPHYLACTIC AND/OR THERAPEUTIC AGENT OF INFECTIOUS DISEASE OR INFLAMMATORY DISEASE [Problem] To provide a therapeutic method specialized for an inflammatory disease such as intractable vasculitis and an infectious disease, which is different from the previous therapeutic methods, in which a target molecule was not determined, by determining the target molecule useful for treating these diseases. [Solution] According to one aspect of the present invention, a prophylactic and/or therapeutic agent for an infectious disease or an inflammatory disease which contains an antibody recognizing apolipoprotein A2 (APOA2) as an active ingredient is provided.
Patent SG-11201909145Q-A (SG)
Title: Communication apparatus and communication method
Inventor: TANAKA YUSUKE
IPC: H04W74/04
Filed: 2018-03-19
Abstract: DESCRIPTION] [Title] COMMUNICATION APPARATUS AND COMMUNICATION METHOD [] A communication apparatus and a communication apparatus that perform wireless communication by a multi- user method are provided. The communication apparatus includes a communication section configured to transmit and receive a wireless signal and a control section configured to control operation as a base station, and transmits a frame that includes schedule information relating to scheduled communication of the own station and can be received by a different wireless terminal and receives schedule information relating to scheduled information of a different base station. The scheduled communication includes multi-user communication of an uplink, and the schedule information includes information relating to a transmission schedule of a frame for inducing multi-user communication of an uplink. Fig. 3
Patent SG-11201910027Y-A (SG)
Title: Bispecific antibody against ox40 and ctla-4
Inventor: ELLMARK PETER
IPC: A61K39/00
Filed: 2018-05-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2018/061084 (22) International Filing Date: 01 May 2018 (01.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1706915.4 02 May 2017 (02.05.2017) GB 1717958.1 31 October 2017 (31.10.2017) GB 1805873.5 09 April 2018 (09.04.2018) GB (71) Applicant: ALLIGATOR BIOSCIENCE AB [SE/SE]; Medicon Village, SE-233 81 Lund (SE). (72) Inventors: ELLMARK, Peter; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). FUREBRING, Christina; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). NORLEN, Per; Alligator Bio- science AB, Medicon Village, SE-233 81 Lund (SE). VEI- TONMAKI, Niina; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). (74) Agent: SMITH, Stephen Edward; Potter Clarkson LLP, The Belgrave Centre, Talbot Street, Nottingham NG1 5GG (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: BISPECIFIC ANTIBODY AGAINST OX40 AND CTLA-4 - (57) : The present invention provides bispecific polypeptides, such as bispecific antibodies, comprising a first binding domain = capable of specifically binding to OX40, and a second binding domain capable of specifically binding to CTLA-4. The invention further — provides compositions of said bispecific polypeptides, as well as methods and uses of the same. ill 1111u°111110111sOHo o Holonomioomnium (10) International Publication Number WO 2018/202649 Al W O 20 18/ 20 26 49 Al [Continued on next page] WO 2018/202649 Al 0 111 Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Patent MT-P993-B (MT)
Title: Antihypertensive combination product
Inventor: GARTHOFF BERNARD DR
IPC: A61K31/55
Filed: 1986-12-03
Abstract: Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula   <IMAGE>   in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group   <IMAGE>  R1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms, R2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino and R3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula <IMAGE>   in which R4 is aralkyl, R5 is hydrogen or alkyl of 1 to 8 C atoms, R6 is hydrogen or alkyl of 1 to 8 C atoms and R7 and R8 are hydrogen, or together, an oxo group, are described.
Patent YU-49038-B (YU)
Title: New derivatives of amidine and their usage thereof
Inventor: ANDERSKEWITZ RALF
IPC: C07D277/00
Filed: 1993-02-03
Abstract: Amidine derivs. of formula (I), in the form of their racemates, enantiomer pure or enriched forms, diastereomer pairs, cis- and trans-isomers, free bases or salts (pref. with physiologically acceptable acids) are new. In (I), R1 and R2 are each CF3, halogen, R5, OR5, COR6, SR6, SOR6, SO2R6, SO2NR5R7, C(OH)R5R7, or R1 and R2 connect neighbouring C atoms on the benzene ring to which they are attached with -CR8=CR9CH=CH-, -CH=CR8CR9=CH-, -CR8=CHCR9=CH-, -OCHR10CH2-, -OCH2O-, -OCH2CH2O-, -(CH2)3-4-, -NHCOO-, -NHCOCH2O-, -COCH2O- or -COCH2CH2O-, each of these gps. being opt. substd. with 1-4C alkyl; R3 is H, OH, CF3, R5, OR6, COR6, CONR5R7, CH2OH, CH2O(1-4C alkyl), SR6, SOR6, SO2R6, SO2NR5R7, NHCO(1-4C alkyl), NHSO2(1-4C alkyl), NR5R7 or C(OH)R5R7 or a heterocyclic 5-ring contg. 1-3 heteroatoms and of formulae (a), (b) or (c); provided that if R3 is R5, R5 can only be H if at least one of R1 and R2 is not H; D, E and G are each CH, N, C(1-4C alkyl) or C-Ph; L is O or S; R4 is halogen, NH2, NH(1-4C alkyl), N(1-4C alkyl)2, OH, 1-4C alkoxy; R5 is H, 1-12C alkyl, phenyl(1-4C)alkyl or Ph (opt. substd. with halogen, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); R6 is 1-12C alkyl, Ph (opt. substd. with halogen, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); R7 is H or 1-12C alkyl; R8 and R9 are each H, OH, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl; R10 is H or 1-4C alkyl; R11 and R12 are each H, OH, halogen, CF3, 1-4C alkyl or 1-4C alkoxy; A is (d), (e), X1A1X2, X2A2X3, X4A2X2, (CH2)1-2NHCO(CH2)1-3X2, -CH=CHA2X2; B is CH=CH, CH=N, S or (f); A1 is 2-4C alkylene, cis- or trans-CH2CH=CHCH2, CH2CCCH2, etc.; A2 is 1-5C alkylene; X1 is O, NH, S, SO, SO2, CO, CH2 or a gp. of formula (d); X2 is O, NH, S or a gp. of formula (e); X3 is NHCO, CONH, SO2NH or a gp. of formula (d); X4 is NHCO, CONH, NHSO2, SO2NH or NHCONH.
Patent AT-399981-B (AT)
IPC: A01K93/00
Filed: 1990-02-07
Granted: 1995-08-25
Abstract: Angling float which has a continuous bore for the fishing line to pass through and for holding the angling shot, with an upwardly protruding float antenna and a stabilising weight arranged in the lower region, characterised in that the hole - as seen in the functional position - runs transversely at a slight inclination to the horizontal, is arranged in the upper third of the float body and comprises two parts of different diameters, the part with the greater diameter, which is intended to hold the shot, forming the higher region of the hole in the functional position. <IMAGE>
Patent AT-385021-B (AT)
Title: Portion-dispensing device for bottled liquids
Inventor: ARTMANN KURT
IPC: G01F11/32
Filed: 1986-03-27
Granted: 1988-02-10
Abstract: The invention relates to a portion-dispensing device for bottled drinks. In this case, a metering chamber is provided in an adapter, a supply valve being provided at the end of the chamber which is positioned upstream, and a discharging valve being provided at the end of the chamber which is positioned downstream. The two valves are actuated simultaneously by a rod 4. The rod is moved by a pump plunger 8 via a driver 7. The pump plunger and, if appropriate, also the pressure chamber obtain the compressed air via a dispensing station 11 into which the adapter together with the bottle is inserted only when required. As a result, it is possible to dispense a multiplicity of drinks in a portioned manner using just one costly and space-consuming dispensing station. <IMAGE>
Patent HU-186911-B (HU)
Title: Compound body
Inventor: DRIESSEN ANTONIUS J G C
IPC: C03C27/10
Filed: 1982-03-08
Abstract: Composite body, a gas discharge lamp having a sodium pressure from 300-600 torr in particular, having an envelope (1, 2) of densely sintered aluminium oxide or of other sodium vapour-resistant materials and a feed-through members (3) of tantalum, niobium or other metals equivalent thereto, the bonding material (6) consisting of a finely dispersed polycrystalline product having a composition in mole % between the following limits:
     at least one oxide chosen from
     and at least one oxide chosen from:
Patent HU-190249-B (HU)
Inventor: FOLEDI TIVADAR
IPC: G01K7/16
Filed: 1984-03-01
Abstract: A találmány relaxációs gömbhőmérő, és zárt fém gömbházban elhelyezkedő, rossz hővezetésű rögzítőeszközre, célszerűen müanyagrúdra van szerelve. A gömbházra (3, 4) épített rögzítőeszközre (10) műanyaggömb (7) van illesztve. Ennek egymástól villamosán szigetelt két fém félgömbből álló burkolata (8) szigetelt ellenálláshuzallal (9) van félgömbönként külön egyenletes sűrűséggel, de ellentétes irányítással tekercselve és a tekercs kivezető pólusai önmagában ismert villamos érzékelő eszközhöz csatlakoznak. Ez utóbbiak célszerűen analóg és/ vagy digitális fűtési intenzitást szabályozó eszközhöz csatlakoznak. Célszerű, ha a gömbház (3,4) kívül és belül sötét színű érdes felülettel rendelkezik. Az ellenálláshuzalt (9) legelőnyösebb nikkelhuzalként kialakítani és zománccal, kétszeres selyemszállal vagy mindkettővel szigetelni (1. ábra).  1. ábra -1-
Patent HU-183125-B (HU)
Title: Process for producing 4-amino-3-bracket-carboxy or cyano-bracket closed-1,2-dihydro-2-oxo-1,8-naphtridine derivatives
Inventor: SCOTESE ANTHONY C
IPC: C07D471/04
Filed: 1980-04-17
Abstract: Compounds of formula
     in which R' is hydrogen, alkyl, cycloalkyl of 5 to 6 carbon atoms, alken(3,4,5 or 6)-yl of 3 to6 carbon atoms oralkyn(3,4,5 or 6)-yl of 3 to 6 carbon atoms; R 2  is-CN,-CO 2 H,-CO 2 R 7  where R 7  is alkyl, -CONHNH 2  or
     where R 8  and R 9  are independently hydrogen or alkyl; R 3  and R 4  are independently hydrogen, alkyl, hydroxyalkyl, dialkylaminoalkyl of 4 to 8 carbon atoms, alkanoyl of 2 to carbon atoms, haloalkanoyl of 2 to 4 carbon atoms, or when taken together with the nitrogen atom to which they are attached. R 3  and R 4  complete a defined heterocyclic group; R 6  and R 6  are independently hydrogen; alkyl of 1 to 4 carbon atoms, halo, alkylamino of 1 to4 carbon atoms, or alkoxy; or a pharmaceutically acceptable saltthereof are disclosed which have gastric anti-secretory, and in some cases diuretic, activity and are useful in pharmaceutical compositions especially for treatment of peptic ulcers. Also described are processes for preparing the compounds and 4-halo-1, 8-naphthyridine intermediates useful in some of the processes.
Patent RS-49581-B (RS)
Inventor: MIJACEVIC-MEDIC LJUBICA
IPC: A61K31/56
Filed: 1997-11-17
Abstract: Novi D-homo sterioidi estranske i androstanske serije, i njihove farmaceutski prihvatljive soli, naznačen time, to im je opšta formula I U kojoj je R vodonik, (C1-10) alkil, fenil, piridil, (C1-10) hidroksialkil i (C1-10) karboksialkil ostatak, a X ima sledeću strukturu gde je R1 vodonik, (C1-6) alkil, benzil, (C1-12)acil, aril ili (C1-3)alkilsulfoniloksi ostatak. Prijava sadrži još 3 patentna zahteva. <patent>
Patent YU-47977-B (YU)
Inventor: WEELINK J M W
IPC: A01K5/00
Filed: 1990-05-07
Abstract: Device for feeding animals comprising at least one feeding fence (2,3) with a frame (4) displaceable over a ground surface, a number of bars attached to the frame which in pairs define openings (6) through which the animals (85) can place their head, and means for displacing the feeding fence (2,3) over the ground surface. The frame supports through support means (17) directly on the ground surface and is provided with a floor plate (84) extending at a small interval above the ground rearward of the frame (4) to a rear edge making contact with the ground, which plate (84) can support at least the front legs of the animals (85) which have pushed their head through the respective openings (6), wherein the feeding fence (2,3) is of the self-catching type having close to each opening (6) a swivel bar (24) locking behind the head of the animal after the head has been pushed through the opening (6), and wherein the displacing means comprise motor drive means (11) which prevent movement of the feeding fence (2,3) in the non-active state.
Patent YU-46543-B (YU)
Title: Postupak za proizvodnju materijala pločastih i ravnih filtera
Inventor: UHRINA S
IPC: B01D39/00
Filed: 1988-05-10
Abstract: POSTUPAK ZA PROIZVODNJU MATERIJALA PLOČASTIH I RAVNIH FILTERA, naznačen time, što se poluproizvod priprema od odpadnih predivnih vlakana pamuka, lana ili konoplje u količini od 1-50 mas.%, prečišćene drvene celuloze koja sadrži više od 92 mas% alfaceluloze i izbeljene papirne celuloze u količini od 5-98 mas.% i zatim se isitni do stepena mlevenja od 22-24В° SR, posle čega se doda kalcinovana diatomejske zemlja u količini 1-45 mas.%: smeša se homogenizuje i doda se 0,3-1,5 mas.% poliamid epoksida ili poliamid poliamin-epihlorhidrin bitumena, tako da odnos prečišćene drvene exeluloze i izbeljene papirne celuloze bude 1:1 do 4:1 smeša se dalje preradjuje na mašini za proizvodnju papira.
Patent ZA-86262-B (ZA)
Title: Therapeutic agents
Inventor: HOUSLEY JOHN ROSINDALE
IPC: C07C231/00
Filed: 1986-01-14
Abstract: Compounds of formula Iand pharmaceutically acceptable salts thereof; in which R, and R<sub>2</sub>, which are the same or different, are H or an optionally substituted hydrocarbon group or R, and R<sub>2</sub> together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R<sub>3</sub> is an optionally substituted aromatic hydrocarbon group; andR<sub>4</sub> is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O)<sub>p</sub>R<sub>5</sub> in which p is 0, 1 or 2 and R<sub>5</sub> is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.
Patent ZA-90545-B (ZA)
Title: 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
Inventor: BEHRENS CARL HENRY
IPC: C07D219/04
Filed: 1990-01-25
Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful in treating tumors in mammals. These dihydrobenz[c]acridine carboxylic acid derivatives have the formula: <CHEM> or a pharmaceutically acceptable salt thereof, where R<1>, R<2>, R<3>, R<4> and R<5> are as defined in the specification. Also provided are pharmaceutical compositions of said compounds. In addition, processes for the preparation of these compounds are disclosed.
Patent ZA-97476-B (ZA)
Title: Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells.
Inventor: MONTMINY MARC R
IPC: C07K14/47
Filed: 1997-01-21
Abstract: One embodiment of the present invention provides a method of testing for compounds which may induce STF-1 transcription. Pancreatic islet cells which express the STF-1/lacz fusion gene are isolated and the effect of various compounds on STF-1 expression is measured by adding the compound of interest to STF-1/lacZ expressing cells. LacZ activity in control and treated cells is then quantitated by a colorimetric assay. Using this method, a large number of compounds can be screened and STF-1 inducing compounds can be identified readily. Another embodiment of the present invention provides a method of using the STF-1 promoter to mark insulin producing pancreatic islet cells in vivo. In this regard, the green fluorescent protein (GFP) served as an indicator. The introduction of the STF-1 green fluorescent protein transgene into pigs allows for the efficient and rapid recovery of insulin producing cells from the pancreas.