Patent SG-11201900215Y-A (SG)
Title: Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by p. acnes
Inventor: DUPIN NICOLAS
IPC: A61P17/10
Filed: 2017-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1#1101111 0 11101 HOE 3E1 0 0111111E1111 10011111011110 1111 OEN International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/011375 Al 18 January 2018 (18.01.2018) W I PO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/496 (2006.01) A61P 17/00 (2006.01) A61K 31/53 (2006.01) A61P 17/06 (2006.01) A61K 45/06 (2006.01) A61P 17/10 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: PCT/EP2017/067774 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (22) International Filing Date: 13 July 2017 (13.07.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: 16305912.4 13 July 2016 (13.07.2016) EP kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicants: UNIVERSITE PARIS DESCARTES [FR/FR]; 12, me de l'Ecole de Medecine, 75006 PARIS (FR). ASSISTANCE PUBLIQUE - HOPITAUX DE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PARIS [FR/FR]; 3, avenue Victoria, 75004 PARIS (FR). INSTITUT NATIONAL DE LA SANTE ET DE LA TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, me de Tolbiac, 75013 PARIS (FR). CENTRE NATION- Published: AL DE LA RECHERCHE SCIENTIFIQUE (CN- — RS) [FR/FR]; 3, me Michel Ange, 75016 PARIS (FR). international 21(3)) with search report (Art. before the expiration of the time limit for amending the UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) claims and to be republished in the event of receipt of [FR/FR]; 4, place Jussieu, 75005 PARIS (FR). amendments (Rule 48.2(h)) (72) Inventors: DUPIN, Nicolas; 95 me Saint Lazare, 75009 — with sequence listing part of description (Rule 5.2(a)) PARIS (FR). CALVEZ, Vincent; 33 rue Gay Lussac, 75005 PARIS (FR). GRANGE, Philippe; 57 avenue du General de Gaulle Bat C2, 77330 OZOIR LA FERRIERE (FR). MARCELIN, Anne-Genevieve; 15 rue des Feuillan- tines, 75005 PARIS (FR). Agent: REGIMBEAU; 20, rue de Chazelles, 75847 PARIS (74) CEDEX 17 (FR). Title: MECLOZINE DERIVATIVES AND DICLAZURIL DERIVATIVES FOR USE IN THE PREVENTION AND/OR THE (54) = TREATMENT OF DISORDERS ASSOCIATED TO THE INFLAMMATION INDUCED BY P. ACNES \ 12' 3 —X—Hef----Y 11 ir) R IN en Ra 11 (I) (II) 11 © . - iii (57) : The present invention relates to compounds of the following general formula (I) or (II) or a pharmaceutically acceptable - salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to the inflammation induced by P. acnes, in particular in the prevention and/or the treatment of acne, psoriasis, chronic urticaria, urticaria pigmentosa, cutaneous autoin- - flammatory diseases, hidradenitis or atopic dermatis.