Patent GB-778944-A (GB)
Title: Improvements relating to plastic solutions for use as dressings for wounds
IPC: A61L26/00
Filed: 1954-03-19
Abstract: A liquid material suitable as a surgical dressing consists of a solution in an organic solvent of a polymer of a vinyl compound of the general formula: <FORM:0778944/IV(a)/1> where R is hydrogen or a hydrocarbon radical, being a polymer of one or more vinyl compounds selected from acrylic and methacrylic esters whereof the alcohol residue has at least two carbon atoms, vinyl esters whereof the acid residue has more than two carbon atoms and vinyl ethers whereof the other radical has at least two carbon atoms or a polymer mixture or copolymer containing at least 10 per cent by weight of monomer units of one or more of said vinyl compounds, the polymer having such a degree of polymerization that it has a viscosity of not more than 1500 cp. at 25 DEG  C. in a 40 per cent solution in ethyl acetate, the solution of polymer in an organic solvent, on evaporation of the solvent, producing a film which does not become sticky at temperatures lower than 35 DEG  C.  The polymer solutions may also contain plasticizers such as castor oil, soya oil, olive oil, coconut oil, cocoa oil, and di-n-octyl and di-iso-octyl phthalates and sebacates.  In examples: (1) ethyl acrylate is polymerized in solution in ethyl acetate in the presence of benzoyl peroxide followed by the addition of butyl acetate; (2) equal parts of ethyl acrylate and ethyl methacrylate are polymerized as in (1) followed by the addition of butyl acetate.  (3) Ethyl methacrylate is polymerized as in (1) followed by the addition of a mixture of ethyl lactate and aliphatic benzine hydrocarbons. (4) Ethyl methacrylate and a mixture of esters of methacrylic acid with alcohols containing 7, 8 and 9 carbon atoms are polymerized as in (1) followed by the addition of isobutyl acetate and castor oil; and (5) methyl methacrylate, vinyl acetate and vinyl isobutyl ether are polymerized as in (1) followed by the addition of isobutyl acetate and dioctyl phthalate.  Also specified as a solvent for the polymers is chloroform.ALSO:A liquid material suitable as a surgical dressing consists of a solution in an organic solvent of a polymer of a vinyl compound of the general formula <FORM:0778944/VI/1> where R is hydrogen or a hydrocarbon radical, being a polymer of one or more vinyl compounds selected from acrylic acid and methacrylic esters whereof the alcohol residue has at least two carbon atoms, vinyl esters whereof the acid residue has more than two carbon atoms and vinyl ethers whereof the other radical has at least two carbon atoms or a polymer mixture or copolymer containing at least 10 per cent by weight of one or more of said vinyl compounds, the polymer having such a degree of polymerization that it has a viscosity of not more than 1500 c.p. at 25 DEG C. in a 40 per cent solution in ethyl acetate, the solution of polymer in an organic solvent, on evaporation of the solvent, producing a film which does not become sticky at temperatures lower than 35 DEG C. The polymer solutions may also contain plasticizers such as castor oil, soya oil, coconut oil, cocoa oil and di - n - octyl and di-iso-octyl phthalates and sebacates.  In examples the following solutions are prepared (1) polyethyl acrylate in a mixture of ethyl and butyl acetates, (2) a copolymer of ethyl acrylate and methacrylate in a mixture of ethyl and butyl acetates, (3) polyethyl methacrylate in a mixture of ethyl acetate, ethyl lactate and benzine, (4) a copolymer of ethyl methacrylate and esters of methacrylic acid containing 7-9 carbon atoms in a mixture of ethyl and isobutyl acetates and castor oil and (5) a copolymer of methyl methacrylate, vinyl acetate and vinyl isobutyl ether in a mixture of ethyl and isobutyl acetates and dioctyl phthalate.  Also specified as a solvent is chloroform.  The solutions are spread in thin layers over a wound or injury and form a covering film as the solvent evaporates.