Patent SG-11201408479W-A (SG)
Title: Injectable supersaturated acetaminophen solution for spinal administration
Inventor: MITIDIERI AUGUSTO
IPC: A61K9/00
Filed: 2013-06-27
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/002042 A1 (51) International Patent Classification: A61K 9/00 (2006.01) A61P 29/00 (2006.01) A61K 31/167 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/055277 27 June 2013 (27.06.2013) Italian English (30) Priority Data: MI2012A001154 29 June 2012 (29.06.2012) IT (71) Applicant: SINTETICA S.A. [CH/CH]; Via Penate, 5, CH-6850 Mendrisio (CH). (72) Inventors: MITIDIERI, Augusto; Via Strecia di Rossi, 2, CH-6922 Morcote (CH). DONATI, Elisabetta; Via Derta, 6, 1-22020 Cavallasca (IT). CARONZOLO, Nicola; Via Collina, 27, CH-6816 Bissone (CH). (74) Agents: COPPO, Alessandro et al.; Notarbartolo & Ger- vasi S.p.A., Corso di Porta Vittoria 9,1-20122 Milano (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17 : — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: INJECTABLE SUPERSATURATED ACETAMINOPHEN SOLUTION FOR SPINAL ADMINISTRATION ra RG.1 40' 30' 20' 10- 0- CJ o CJ o o ^ (» Time (hours) ft. ^ vehicle (TT) acetaminophen \"10 (jg (fT) acetaminophen: 100' pg (IT) o CJ O (57) Abstract: The present invention relates to an acetaminophen injectable aqueous solution for use in the treatment or in the pre - vention of pain by spinal administration, wherein said acetaminophen injectable solution supersaturated. In certain embodiments, is the acetaminophen injectable aqueous solution is administered simultaneously, separately or sequentially with a local anaesthetic by spinal administration.