Patent SG-11201804711R-A (SG)
Title: Compounds and methods for kinase modulation, and indications therefor
Inventor: WU GUOXIAN
IPC: C07D471/04
Filed: 2016-12-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date .... ..sr.) 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO 1111111111111111111111111111 International III 2017/100201 Publication IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII Al Number (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 471/04 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/437 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2016/065179 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 6 December 2016 (06.12.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/264,180 7 December 2015 (07.12.2015) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PLEXXIKON INC. [US/US]; 91 Bolivar GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Drive, Suite A, Berkeley, California 94710 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: WU, Guoxian; c/o Plexxikon Inc., 91 Bolivar TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Drive, Suite A, Berkeley, California 94710 (US). WU, Jef- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, frey; c/o Plexxikon Inc., 91 Bolivar Drive, Suite A, Berke- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ley, California 94710 (US). CHAN, Katrina; c/o GW, KM, ML, MR, NE, SN, TD, TG). Plexxikon Inc., 91 Bolivar Drive, Suite A, Berkeley, Cali- fornia 94710 (US). DONG, Ken; c/o Plexxikon Inc., 91 Declarations under Rule 4.17: Bolivar Drive, Suite A, Berkeley, California 94710 (US). — EWING, Todd; Plexxikon Inc., 91 Bolivar Drive, as to the applicant's entitlement to claim the priority of the c/o earlier application (Rule 4.17 (iii)) Suite A, Berkeley, California 94710 (US). IBRAHIM, Prabha N.; c/o Plexxikon Inc., 91 Bolivar Drive, Suite A, Published: Berkeley, California 94710 (US). LIN, Jack; c/o with international search report (Art 21(3)) Plexxikon Inc., 91 Bolivar Drive, Suite A, Berkeley, Cali- fornia 94710 (US). SPEVAK, Wayne; c/o Plexxikon Inc., — before the expiration of the time limit for amending the Bolivar Drive, A, Berkeley, claims and to be republished in the event of receipt of 91 Suite California 94710 48.2(h)) (US). ZHANG, Ying; c/o Plexxikon Inc., 91 Bolivar amendments (Rule Drive, Suite A, Berkeley, California 94710 (US). (74) Agents: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, California 94301-1479 (US). (54) Title: COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR — Z 3 Il \ Z2 ( I ) ' 4 t Il 0 el 0 0 Il IN 1-1 (57) : Disclosed are compounds 0 deuterated analog thereof, wherein Z 2 , Z and Z are as described herein, compositions thereof, and uses thereof 3 , ei of Foiinula I or 5 a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a O