Patent SG-11201806419R-A (SG)
Title: Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
Inventor: STAFFORD RYAN
IPC: A61P35/00
Filed: 2017-01-27
Abstract: Tumorgrowth curves Tumor size (Day 18) 2000 E 1500 ••• a, 41 , 1000 • • g 500 n Vehicle 10 mg/kg Conjugate A 0 E E 1000 N L 5 500 10 20 30 40 W O 20 17 / 13 26 15 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/132615 Al 3 August 2017 (03.08.2017) WIPO I PCT (51) International Patent Classification: A61K 47/68 (2017.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2017/015501 (22) International Filing Date: 27 January 2017 (27.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/287,824 27 January 2016 (27.01.2016) US (71) Applicant: SUTRO BIOPHARMA, INC. [US/US]; 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). (72) Inventors: STAFFORD, Ryan; c/o Sutro Biopharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). YAM, Alice; c/o Sutro Biopharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). GILL, Avinash; c/o Sutro Bio- pharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). PENTA, Kalyani; c/o Sutro Biopharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). LI, Xiaofan; c/o Sutro Biopharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). SATO, Aaron; c/o Sutro Biopharma, Inc., 310 Utah Avenue, Suite 150, South San Francisco, California 94080 (US). (74) Agents: PATHAK, Rahul et al.; Squire Patton Boggs (US) LLP, 620 Hansen Way, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(1)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) (54) Title: ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODY CONJUG- ATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES Days post treatment start -e- Vehicle -at- 10 mg/kg Conjugate A FIG. 7A FIG. 7B (57) : Provided herein are antibody conjugates with binding specificity for CD74, wherein the antibody comprises a non- natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC- S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-5136, HC-525, HC-A40, HC-5119, HC-5190, HC-K222, HC-R19, HC-Y52, or HC-570, according to the Kabat, Chothia, or EU numbering scheme, and compositions comprising the antibody conjugates, includ- ing pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy. 111111111111110111011111111111010111110111111110111111111111101111111111111111110111111