baber/WOPTO huggingface dataset:
Patent CA-2505922-A1 (CA)
Title: Cytomodulating peptides for treating interstitial cystitis
Inventor: FONG TIMOTHY C
IPC: A61K38/08
Filed: 2003-11-17
Abstract: The methods and compositions relate to treatment of disorders of the bladder.  In particular, the methods provide for treatment of interstitial cystitis and related disorders. The methods further comprise treatment to affect various manifestations associated with interstitial cystitis, including, reducing histamine release, modulating Substance P expression, modulating nerve growth factor expression, modulating levels of various cytokines, and maintaining integrity of the urine/blood barrier.
Patent CA-2507110-A1 (CA)
Title: Carbamic acid esters with an anticholinergic action
Inventor: GRAUERT MATTHIAS
IPC: C07D451/06
Filed: 2003-11-19
Abstract: The invention relates to novel carbamic acid esters of general formula (1) (see formula 1) in which X- is an anion with a single negative charge, A is a double-bonded group, R1 and R2 are each optionally substituted alkyl or together represent an alkylene bridge, and R3 and R4 each represent hydrogen or optionally substituted alkyl, alkenyl, alkynyl, aryl etc. The invention also relates to a method for producing said esters and to their use as medicaments, in particular medicaments with an anticholinergic action.
Patent CA-2507950-A1 (CA)
Inventor: AHARI FREDERICK
IPC: A61B10/02
Filed: 2003-11-21
Abstract: A bioabsorbable sealant plug that expands in response to contact with moisture in a mammalian body is optimally positioned in a biopsy tract to seal the biopsy tract when a biopsy procedure is completed. In a first method, the leading end of the sealant plug is advanced through the lumen of a coaxial needle by a plunger until a leading end of a supporting leg abuts the patient's skin surface. A second method is performed with a pistol-shaped tool having a trigger that enables adjustment of the plunger. A third embodiment includes a plunger having a bifurcated end that grasps the plug. A fourth embodiment has a turning nut that causes compression of a gasket that clamps down on the plug. A supporting rod and coaxial needle are in parallel relation to one another in a fifth embodiment.
Patent CA-2508492-A1 (CA)
Inventor: LITTEK WOLFRAM
IPC: B29C48/21
Filed: 2005-05-20
Abstract: The present invention relates to a process for coating substrates with polyamides by the use of nanoscale particles with coating rates of at least 250 m/min, as a result of which "edge waving" and "neck-in" are prevented.
Patent CA-2509223-A1 (CA)
Inventor: O'CONNOR JOSEPH G
IPC: D04H3/04
Filed: 2003-11-06
Abstract: L'invention concerne un procédé de fabrication et un tissu pour machine à papier ou industriel. Ledit procédé consiste à appliquer, de manière contrôlée, un matériau de résine polymère sur des emplacements discrets présélectionnés d'un substrat base, sous forme de gouttelettes de granulométrie moyenne de 10? (10 microns), afin de lier des fils par point, de lier des bandes enroulées en spirale ou de lier des couches de tissu ensemble.
Patent CA-2512824-A1 (CA)
Title: Improved oral delivery of peptides
Inventor: STERN WILLIAM
IPC: A61K38/23
Filed: 2004-01-21
Abstract: Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing an active peptide that is amidated at a site that is not naturally amidated.
Patent CA-2516816-A1 (CA)
Title: Transmucosal drug delivery system
Inventor: MCCARTY JOHN A
IPC: A61K9/14
Filed: 2004-02-24
Abstract: Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic species having ionic characteristics opposite to that of the pharmaceutical agent. Such lipophilic associations manifest high thermodynamic activity, as evidenced by their being predominantly in a liquid phase at room temperature or solvated in a lower-than-water dielectric solvent. Further the pharmaceutical agent being solubilized means that dissolution is not rate limiting to transmucosal absorption. This LA or LA-solvate is formulated into a low dielectric dosage form, from whence, upon the dosage form's hydration, the pharmaceutical agent is driven through the mucosal tissue and into systemic circulation. The invention therefore provides an enhanced transmucosal drug delivery system for ionizable pharmaceutical agents at or near physiological pH.
Patent CA-2520370-A1 (CA)
Title: Merchandise package on which images for forming three-dimensional image are disposed
Inventor: SHIBANO KUNIO
IPC: B65D5/42
Filed: 2004-03-17
Abstract: A package of goods capable of observing a three-dimensional image. Two sides (11a, 11c) forming the package (1) of goods are attached with an image A and an image B which are paired to form a three-dimensional image. When the individual images A and B are arranged side by side while being paired, the two images provide a three-dimensional image to an observer. The package of goods is thereby imparted with a novel discriminating power and a client purchased the goods can enjoy a three-dimensional image by arranging the packages of goods side by side, thus imparting a novel function to the package of goods.
Patent CA-2521172-A1 (CA)
Title: 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
Inventor: ANDERSEN KIM
IPC: A61K31/4409
Filed: 2004-04-02
Abstract: The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
Patent CA-2522572-A1 (CA)
Inventor: HOLMGREN LARS
IPC: E21B7/28
Filed: 2004-04-07
Abstract: A drill bit assembly for direct removal of rock by means of a rotatable bit assembly (5) that includes a plurality of cutters or choppers (7). According to the invention, a number of cutters (7) are so disposed in relation to each other on the bit assembly (5) that a subsequent cutter (7b), seen in the direction of rotation, will engage an edge created by the action of a preceding cutter (7a).
Patent CA-2524384-A1 (CA)
Inventor: NAPPA MARIO J
IPC: C07C45/58
Filed: 2004-06-18
Abstract: The present invention relates to methods of using at least one fluoroketone selected from monobromoperfluoroketones, monohydromonobromoperfluoroketones, (perfluoroalkoxy)monobromoperfluoroketones, (fluoroalkoxy)monobromoperfluoroketones, and monochloromonobromoperfluoroketones for i) extinguishing fire by applying to the fire such a fluoroketone, ii) preventing fire in an air-containing enclosed area containing combustible materials by introducing into the area such a fluoroketone and maintaining the fluoroketone in an amount sufficient to suppress combustion of combustible materials in the enclosed area, and iii) reducing or eliminating the flammability of a flammable working fluid, by mixing between about 0.1 to about 99 percent by weight of such a fluoroketone with the flammable working fluid.
Patent CA-2525139-A1 (CA)
Inventor: ALLAN BARRETT W
IPC: C07K16/30
Filed: 2004-05-20
Abstract: The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
Patent CA-2525952-A1 (CA)
Inventor: GALE ROBERT PETER
IPC: A61K33/243
Filed: 2003-05-20
Abstract: The present invention relates to methods for treating cancer comprising administering a combination of gemcitabine and a liposomal platinum complex, pharmaceutical compositions comprising gemcitabine and a liposomal platinum complex, and kits comprising unit dosage forms of gemcitabine and a liposomal platinum complex.
Patent CA-2526685-A1 (CA)
Inventor: HILLEBRAND HELKE
IPC: A01H5/00
Filed: 2005-11-01
Abstract: The present invention relates to expression cassettes comprising transcription regulating sequences with root-preferential or root-specific expression profiles in plants obtainable from Arabidopsis thaliana genes At1g66280, At1g74500, At1g49570, At1g70710, At5g66690, At3g29630, At5g48070, orAt4g17800.
Patent CA-2527458-A1 (CA)
Inventor: WILTSHIRE H D JOHN
IPC: G06Q50/10
Filed: 2005-11-21
Abstract: A system, method and computer program for enabling signings/dedications on a remote basis is provided. A first computer at a first location is associated with an individual from whom a signature or dedication is required. A second computer at a location where the signing or dedication is required is linked to the first computer so as to provide a two-way audiovisual communication system. The second computer is operable to receive input from one or more individuals regarding their request for a signature and/or dedication, and to communicate the request to the first computer. The first computer is operable to permit the individual associated with the first computer to review the request, and based on such request provide a signature and/or personalized dedication as an input to an input device connected to the first computer. The first computer transmits the signature and/or personalized dedication from the first computer to the second computer. The second computer is operable to receiving the signature and/or personalized dedication, and provide the signature and/or personalized dedication to a plotting apparatus connected to the second computer. The plotting apparatus is operable to apply the signature and/or personalized dedication introduced to the plotting apparatus to an article, substantially in the handwriting of the individual associated with the first computer, based on the operation of the plotting apparatus. A computer program for enabling the functions described is also provided. A related method is also disclosed.
Patent CA-2528130-A1 (CA)
Title: Method and apparatus for stimulating hydrocarbon wells
Inventor: FRAZIER W LYNN
IPC: E21B34/10
Filed: 2005-11-28
Abstract: One or more flapper valve assemblies are placed in a casing string extending through one or more hydrocarbon bearing intervals. The flapper valve assemblies are placed between some of the hydrocarbon bearing intervals. In an open or inoperative position, the flapper valve assemblies are full opening compared to the casing string. The hydrocarbon bearing intervals are stimulated, typically by fracing, starting with the bottom zone. The flapper valve assembly immediately above the stimulated interval is manipulated to allow it to close, preventing downward flow in the well and thereby isolating the lower stimulated interval so an upper interval can be stimulated. The well is easy to put on production because the flapper valves will normally open simply by opening the well at the surface.
Patent CA-2529243-A1 (CA)
Inventor: HAWKES TIMOTHY ROBERT
IPC: C12N15/82
Filed: 2004-06-09
Abstract: A method of producing male or female sterile plants comprising providing means for inactivating a herbicide and means for reactivating the thus inactivated herbicide, wherein the herbicide inactivating means is provided within vegetative tissues and the reactivating means is provided in either the male or female reproductive structures of the plant, so that the vegetative, but not reproductive, structures are protected from the phytotoxic activity of the herbicide when applied to the plant.
Patent CA-2529822-A1 (CA)
Title: Arc chute assembly
Inventor: SHEA JOHN J
IPC: H01H73/18
Filed: 2005-12-13
Abstract: The arc plates of an arc chute assembly for a circuit breaker are supported in spaced, stacked relation by a structural shell molded of a gas evolving resin. Generation of arc gases, that cool the arc thereby increasing the current interruption capability of the breaker, can be further enhanced by gas evolving additives included in the resin. Arc gas flow is increased to further cool the arc by molding the interior walls of the structural shell to form venturies between the arc plates. One or more elongated fibers wrapped around the stack of arc plates in an oval strengthen the structural shell to withstand the increased pressure generated by the high arc gas volume.
Patent CA-2530988-A1 (CA)
Title: Adjustable ergonomic back for a seat
Inventor: PROULX MICHAEL
IPC: A47C7/46
Filed: 2005-12-19
Abstract: An adjustable ergonomic back for a seat is disclosed. The back has a plurality of back cushions, each cushion having at least one adjustment area. It further comprises a structural shell having a plurality of voids therein. A plurality of thin flexible elements are located between the back cushions and the structural shell, each flexible element being attached to the structural shell. Each of the flexible elements has a front surface and a back surface, the front surface being in contact with a respective adjustment area of one of the plurality of back cushions. The back further has a plurality of actuators located between the flexible elements and the structural shell, each of the actuators being in contact with one of the respective back surfaces of the flexible elements and exerting a pressure on the back surface.
Patent CA-2531793-A1 (CA)
Inventor: V D POL MAURITS EGBERTUS
IPC: B21D53/78
Filed: 2004-07-08
Abstract: A method for the production of a semi-finished product (13) for a wing-shaped element (15) having, in cross-section, a front edge (2), a rear edge (14) and an arched bottom wall (3) and an arched top wall (4) that extend some distance apart between the front edge (2) and the rear edge (14), comprises the following steps: bending the sheet (1) with the formation of two panels (3, 4) as well as a curved region (2) which the panels (3, 4) adjoin, placing a former (10) in the bent sheet (1) with the front edge of the former (9) positioned in the curved region (2), forcing the pressure member (8) towards a rubber cushion (7) with the bent sheet (1) enclosed between them and deforming said sheet between the former (10) and the rubber cushion (7), placing the shaped sheet (F) in a rubber press provided with a bottom block having a cavity (16) which has a shape that at least approximately corresponds to the external shape of one of the walls (3, 4) of the shaped sheet (P), pressing the shaped sheet (F) with former (10) between the bottom block (11) and a rubber mat (12), removing the semi-finished product (13) from the rubber press.
Patent CA-2532795-A1 (CA)
Title: Sense antiviral compound and method for treating ssrna viral infection
Inventor: IVERSEN PATRICK L
IPC: A61K/
Filed: 2004-08-06
Abstract: The invention provides sense antiviral compounds and methods of their use in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Coronaviridae families and hepatitis E virus in the treatment of a viral infection. The sense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of (12-40) subunits, including at least (12 )subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 3'-terminal end (40) bases of the negative-sense RNA  strand of the virus.
Patent CA-2533211-A1 (CA)
Inventor: WILHELM MAIK
IPC: G01M13/04
Filed: 2006-01-16
Abstract: A method and an apparatus (1) are described for testing the adhesive strength of overlays (3) attached to the inside of plain bearing bushings (2). The method is characterized in that clearance is specified between the plain bearing bushing (2) to be tested and a rotating or oscillating pin (5) extending through the plain bearing bushing (2). A liquid medium is fed into the gap (8) between the plain bearing bushing and the pin. Plain bearing bushing (2) and pin (5) are moved oscillatingly relative to one another perpendicularly to the bushing axis (9) for a given period with a given force and the plain bearing bushing (2) is examined after the load test for damage to the overlay (3).      The corresponding apparatus comprises a pin (5), which is mounted rotatably with its two ends in a pin receptacle (20) and on which there is arranged a first drive means (7). In addition, a bushing receptacle (10) is provided, in which the plain bearing bushing (2) to be tested is interference-fitted, wherein the pin (5) is mounted with predetermined clearance in the plain bearing bushing (2).      The apparatus additionally comprises means for bringing about oscillating relative movement of bushing receptacle (10) and pin receptacle (20).
Patent CA-2534691-A1 (CA)
Title: Process and apparatus for manufacture of fertilizer from manure and sewage
Inventor: GORBELL BRIAN N
IPC: C05F3/00
Filed: 2005-07-18
Abstract: This invention discloses systems and methods for conversion of manure to novel fertilizer and/or soil builder products useful as input for organic farming operations. The equipment systems comprise a gas turbine generator unit (preferred heat source), a dryer vessel and a processing unit, wherein the connection between the gas turbine and the dryer vessel directs substantially all the gas turbine exhaust into the dryer vessel and substantially precludes the introduction of air into the dryer vessel. The dryer vessel receives the manure for contact with the turbine exhaust gases to convert the manure to a dry material, which is passed to the processing unit where it is formed into granules, pellets or other desired form for the final dry fertilizer product. The method comprises drying, heating and converting the manure to form novel self binding fertilizer and soil builder type products for organic farming and other uses.
Patent CA-2534871-A1 (CA)
Title: Three-gene test to differentiate malignant from benign thyroid nodules
Inventor: ENG CHARIS
IPC: C12Q1/04
Filed: 2006-02-15
Abstract: Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided.
Patent CA-2535614-A1 (CA)
Title: Quinazoline analogs as receptor tyrosine kinase inhibitors
Inventor: ZHAO QIAN
IPC: C07D401/12
Filed: 2004-08-10
Abstract: This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula (I) as type I  receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Patent CA-2538271-A1 (CA)
Title: Nonaqueous cell with improved thermoplastic sealing member
Inventor: MARPLE JACK W
IPC: H01M50/195
Filed: 2004-10-07
Abstract: An electrochemical battery cell with an aperture in the container or cell cover has the aperture sealed by an improved thermoplastic sealing member, which forms at least part of the cell~s pressure relief vent and is made from a material comprising a thermoplastic resin and more than 10 weight percent of a thermal-stabilizing filler, to provide an effective seal and a reliable pressure relief vent over a broad temperature range.
Patent CA-2538431-A1 (CA)
Inventor: CHUANG SU-LIAN
IPC: A63F9/12
Filed: 2006-02-22
Abstract: A three dimensional jigsaw puzzle includes a topmost puzzle piece, a bottommost puzzle piece and mediate puzzle pieces of different dimensions. A  connection device is provided between two adjacent puzzle pieces to facilitate combination of the two adjacent puzzle pieces such that an object is formed after the combination of all the puzzle pieces.
Patent CA-2540089-A1 (CA)
Title: Methods for manufacturing volume bragg grating elements
Inventor: VOLODIN BORIS LEONIDOVICH
IPC: G11B11/00
Filed: 2004-09-23
Abstract: Methods for recording volume Bragg grating structures having a target wavelength are disclosed. Such a method may include providing a photosensitive recording medium, bringing a first face of the recording medium into contact with a face of a prism, the prism being made of a material that is transparent at a recording wavelength, and recording a Bragg grating onto the recording medium by exposing the prism to an incident light wave at the recording wavelength.
Patent CA-2547329-A1 (CA)
Inventor: SORENSEN EDITH TROST
IPC: A61Q11/00
Filed: 2003-12-08
Abstract: The present invention provides a solid, oral tooth whitening composition comprising a tooth whitening agent comprising calcium pyrophosphate present in an amount between o.5% and 9% by weight of the composition, excluding any coating. In one embodiment, the composition of the invention comprises an additional tooth whitening agent.
Patent CA-2551335-A1 (CA)
Inventor: KING JULIA D
IPC: B60N2/90
Filed: 2006-06-27
Abstract: A portable restraint system mountable to a vehicle seat may comprise a booster seat, a restraint harness mounted to the booster seat and a mounting harness coupled to the restraint harness. The restraint harness may be configured to restrain a passenger positioned on the booster seat. The mounting harness may have a connector attached thereto configured to releasably engage an anchora ge of the vehicle.
Patent CA-2551874-A1 (CA)
Title: Water-and oil-repellent fluoroacrylates
Inventor: CALDWELL GREGG A
IPC: C07C233/18
Filed: 2004-12-28
Abstract: Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: wherein: n = 1 to 4, R =  hydrogen or an alkyl group of 1 to 4 carbon atoms, m = 2 to 8, Rf = CnF2n+1, y = 0 to 6, and q = 1 to 8; (b) at least one unbranched symmetric diisocyanate;  and (c) at least one hydroxy-terminated alkyl (meth) acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.
Patent CA-2558027-A1 (CA)
Title: Polymeric drug delivery system for hydrophobic drugs
Inventor: ENSCORE DAVID
IPC: A61K9/28
Filed: 2005-03-03
Abstract: An oral delivery system for Class II drugs that have low oral bioavailability due to their insolubility in water and slow dissolution kinetics and method for making such a drug delivery system are disclosed herein. The formulation may be a controlled release or immediate release formulation. The immediate release formulation contains a Class II drug, together with a hydrophobic polymer, preferably a bioadhesive polymer. In one embodiment, the drug and polymer are co-dissolved in a common solvent. The solution is formed into small solid particles by any convenient method, particularly by spray drying.  The resulting particles contain drug dispersed as small particles in a polymeric matrix. The particles are stable against aggregation, and can be put into capsules or tableted for administration. The controlled release formulations contain a BCS Class II drug and a bioadhesive polymer. The controlled release formulations may be in the form of a tablet, capsules, mini-tab, microparticulate, or osmotic pump. Enhancement of oral uptake of the drug from use of bioadhesive polymers occurs through (1) increased dissolution kinetics due to stable micronization of the drug, (2) rapid release of the drug from the polymer in the GI tract; and (3) prolonged GI transit due to bioadhesive properties of the polymers. The combination of these effects allows the preparation of a compact, stable dosage form suitable for oral administration of many class II drugs.
Patent CA-2559229-A1 (CA)
Title: Imidazopyridine and imidazopyrimidine derivatives as antibacterial agents
Inventor: STARR JEREMY TYSON
IPC: A61P31/00
Filed: 2005-03-07
Abstract: Compounds of formula I and methods for their preparation are disclosed.  Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.