Patent SG-11201910101S-A (SG)
Title: Alphavirus neoantigen vectors
Inventor: BLAIR WADE
IPC: A61K35/76
Filed: 2018-05-08
Abstract: Title: ALPHAVIRUS NEOANTIGEN VECTORS Patient 110 Candidate Neoanligen Sequences 114 Presentation Identification System 160 Presentation Information 165 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT omit VIII °nolo Holollm iflo oimIE (10) International Publication Number WO 2018/208856 Al (51) International Patent Classification: A61K 35/76 (2015.01) CO7K 14/705 (2006.01) A61K 39/12 (2006.01) C12N 15/86 (2006.01) C07K 14/18 (2006.01) (21) International Application Number: PCT/US2018/031696 (22) International Filing Date: 08 May 2018 (08.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/503,283 08 May 2017 (08.05.2017) US 62/523,201 21 June 2017 (21.06.2017) US 62/590,163 22 November 2017 (22.11.2017) US (71) Applicant: GRITSTONE ONCOLOGY, INC. [US/US]; 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). (72) Inventors: BLAIR, Wade; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). JOOSS, Karin; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). RAPPA- PORT, Amy, Rachel; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). SCALLAN, Ciaran, Daniel; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). GITLIN, Leonid; Gritstone Oncology, Inc., 5858 Horton Street, Sutie 210, Emeryville, CA 94608 (US). (74) Agent: NEWMAN, Zachary, R. et al.; Fenwick & West LLP, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Vaccine 118 1-1 00 FIG 2A 00 1-1 (57) : Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor © of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines. C [Continued on next page] WO 2018/208856 Al MIDEDIMOMMIDEFIEHIMIIMMERIMODEVOIS Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))