baber/WOPTO huggingface dataset:
Patent RU-2715893-C2 (RU)
Inventor: JOVCHEVA ELEONORA
IPC: A61P35/00
Filed: 2015-03-26
Granted: 2020-03-04
Abstract: FIELD: medicine; pharmaceuticals.SUBSTANCE: group of inventions relates to pharmacy and oncology. Disclosed are a combination of an FGFR inhibitor selected from N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine or its salt, solvate and N-(2-fluoro-3,5-dimethoxyphenyl)-N-(1H-imidazol-2-ylmethyl)-3-(1-methyl-1H-pyrazole-4-yl)pyrido[2,3-b]pyrazine-6-amine or a salt thereof, a solvate and an IGF1R inhibitor for preventing or treating cancer, a composition of the same application comprising said combination, use thereof for preparing a medicinal agent for preventing or cancer treatment (embodiments), method of using them (embodiments) and a combined preparation of the same purpose.EFFECT: technical result is a combination of said FGFR inhibitors with an inhibitor of IGF1R (according to examples - GSK1838705A, BMS-754807) blocks the development of primary resistance to the treatment of small cell lung cancer cells.24 cl, 3 dwg, 1 tbl
Patent RU-2679092-C2 (RU)
Title: Сердцевина теплообменника
Inventor: BUNGO TAKUYA
IPC: F28F1/30
Filed: 2015-05-25
Granted: 2019-02-05
Abstract: Изобретение относится к области теплотехники и может быть использовано в трубчато-ребристых теплообменниках. Формирование гофрированного теплообменника с трубчато-ребристой сердцевиной, такого, что направление, в котором жалюзи подрезаны и отогнуты, наклонено только в одном направлении, причем высота Н (мм) сердцевины, которая представляет собой расстояние, на которое разнесена между собой пара бачков (расстояние части пространства между парой бачков), ширина W (мм) жалюзи, изготовленных подрезкой и отгибом, в направлении основного потока текучей среды и угол θ жалюзи, изготовленных подрезкой и отгибом, заданы так, чтобы удовлетворить неравенству Н>Q/(Q-1)×ΔН, где Н обозначает высоту сердцевины теплообменника, Qобозначает отношение величины теплообмена на "гору" между однонаправленными ребрами и разнонаправленными ребрами в части воздушного потока, а ΔН обозначает величину увеличения области уменьшенного теплообмена в сердцевине теплообменника в результате замены разнонаправленных ребер на однонаправленные ребра. Технический результат - улучшение эффективности теплообмена. 9 ил.
Patent RU-2724527-C2 (RU)
Inventor: PRAKASH THAZHA P
IPC: C12N15/11
Filed: 2015-05-01
Granted: 2020-06-23
Abstract: FIELD: biotechnology. 
     SUBSTANCE: described is a group of inventions comprising a compound consisting of a group of a conjugate and a modified oligonucleotide, a composition for treating a disease associated with an excess of human growth hormone, containing said compound, use of the compound or composition in a method of treating a disease associated with an excess of human growth hormone, and use of the compound or composition in a method for reducing levels of the human growth hormone receptor. 
     EFFECT: invention extends the range of products directed to the human growth hormone receptor. 
     4 cl, 244 tbl, 139 ex
Patent RU-2676426-C2 (RU)
Title: Способ изготовления многослойного упаковочного материала и многослойный упаковочный материал
Inventor: OHMAN PETER
IPC: B65D65/40
Filed: 2015-07-03
Granted: 2018-12-28
Abstract: Настоящее изобретение предлагает способ изготовления многослойного упаковочного материала (10a, 10b), включающего первый наружный слой из прозрачного полимера (16), который должен быть обращен наружу упаковки, изготовленной из многослойного упаковочного материала, подложечный слой (11) и второй наружный слой (14(a, b, c)) из термосваривающегося полимера, расположенный на другой стороне подложечного слоя, противоположной по отношению к первому наружному слою, и опционально один или несколько дополнительных слоев материалов между вышеупомянутым подложечным слоем и вышеупомянутым вторым наружным полимерным слоем, причем данный многослойный упаковочный материал характеризуется визуальным или тактильным рисунком (17) или их сочетанием в первом наружном прозрачном полимерном слое. Настоящее изобретение также предлагает многослойный упаковочный материал, изготовленный данным способом, и упаковочный контейнер для жидкого или полужидкого пищевого продукта, изготовленный из многослойного упаковочного материала. 3 н. и 23 з.п. ф-лы, 12 ил.
Patent RU-2720357-C2 (RU)
Inventor: SEHLSTEDT MARTIN
IPC: G10L25/84
Filed: 2014-12-01
Granted: 2020-04-29
Abstract: FIELD: means for estimating background noise.SUBSTANCE: reducing current estimated value of background noise in response to determination that segment of audio signal contains music, and determining that current estimated value of background noise exceeds minimum value, when power level of audio signal segment is less than threshold exceeding long-term minimum energy level (lt_min), which is determined by multiple previous segments of audio signal, and there is no pause in segment of audio signal. Background noise evaluation unit is also configured to reduce the current estimated background noise value in response to the determination that the audio signal segment contains music, and determining that the current estimated value of the background noise exceeds the minimum value when the power level of the audio signal segment is less than the threshold.EFFECT: technical result consists in improvement of accuracy of detection in audio signal of speech or music.18 cl, 9 dwg
Patent RU-2739001-C2 (RU)
Title: Heat exchanger for baking ovens
Inventor: ODORIKO Marko
IPC: F24C3/00
Filed: 2017-09-19
Granted: 2020-12-21
Abstract: FIELD: heat exchange. 
     SUBSTANCE: group of inventions relates to a convective furnace with a heat exchanger intended for preparation of food products and operating on gas fuel or liquid types of fuel. Gas furnace consists of a baking chamber equipped with a bottom wall and a roof wall, a fan with a horizontal axis of rotation (X—X), a burner with a preliminary mixing system and a heat exchanger. Heat exchanger includes at least two bundles of tubes installed opposite to each other between place for inlet of flue gases, made with possibility of connection with gas burner of gas furnace, and outlet hole for flue gases, made with possibility of connection with exhaust manifold of said gas furnace. Each tube bundle comprises at least two pipe sections, each of which consists of at least one pipe. Said sections of tubes lie in planes parallel to each other, perpendicular to horizontal axis (X—X), and are connected to each other in series by means of at least one transfer element so that flue gases can pass through each of sections of pipes in direction opposite direction of flue gas flow in section of pipes lying in adjacent plane. Pipe sections are located overlapping each other next to each other, so that the contours of the pipe section lying in the first plane completely overlap—if viewed along horizontal axis (X—X)—contours of pipe sections located in the following planes. 
     EFFECT: disclosed is a heat exchanger for baking ovens. 
     14 cl, 32 dwg
Patent RU-2746972-C2 (RU)
Title: Gear train
Inventor: KARRI ZHAN-POL
IPC: F16H57/12
Filed: 2017-10-30
Granted: 2021-04-22
Abstract: FIELD: aircraft construction.SUBSTANCE: group of inventions relates to the field of aircraft construction. The flight control system of the aircraft contains a gear train and a control stick designed to control the gear train, while the specified gear train contains a system of gears, including the first gear wheel on the first axis and the second gear wheel on the second axis, while the first and second gears are configured to engage. The gear train is equipped with a frictional transmission containing a first rotating element mounted on a first axis and configured to frictionally drive a second rotating element mounted on a second axis. The flight control system also contains a position sensor, which is connected to the output of the second axis, is configured to determine the position of the control stick, and contains a rotating variable differential transducer configured to generate an electrical signal to control engine thrust. A method of manufacturing the system is also claimed according to cl. 1.EFFECT: system reliability is improved.13 cl, 7 dwg
Patent RU-2724103-C2 (RU)
Title: Selective androgen receptor destroying agents (sard) and methods of using thereof
Inventor: NARAYANAN RAMESH
IPC: C07C255/60
Filed: 2016-04-21
Granted: 2020-06-22
Abstract: FIELD: pharmaceuticals.SUBSTANCE: invention relates to compounds—selective androgen receptor destructors (SARD), represented by structure of formulas I and VII. In formula, I T is OH; Z is CN; Y is CF; Ris CH; Ris hydrogen, C-C-alkyl; Q, Qand Qare each independently selected from hydrogen, CN; Qand Qeach represent hydrogen or phenyl substituted with halogen; where at least two Q, Q, Q, Qand Qare not hydrogen; or Qand Qare bonded together to form unsubstituted C-C-carboxyclic ring. In formula VII, T denotes OH; Z is CN; Y is CF; Ris CHand Qis F, Cl, Br, I. Invention also refers to specific compounds of said formulas and a pharmaceutical composition containing them.(I)(VII).EFFECT: selective androgen receptor destructive ligands (SARD) and methods for use thereof are disclosed.15 cl, 8 tbl, 12 ex, 12 dwg
Patent RU-2722044-C2 (RU)
Inventor: IVANOVICH Zhoran
IPC: A01N1/02
Filed: 2016-04-22
Granted: 2020-05-26
Abstract: FIELD: medicine.SUBSTANCE: invention relates to a method for cell preservation. For in vitro or ex vivo preservation of animal cells, preferably human, stage of holding the above cells with moderate hypothermia in a hypoxic and/or hypercapnic environment for 12 to 72 hours to their preservation with deep hypothermia.EFFECT: invention allows to increase cell survival and ability to proliferation.18 cl, 5 dwg, 2 ex
Patent RU-2701513-C2 (RU)
Title: Pharmaceutical composition containing electrohydrodynamically produced fibers, composition having improved retention time at site of use
Inventor: HANSEN JENS
IPC: A61K31/34
Filed: 2016-11-18
Granted: 2019-09-27
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to electrospinning fibres, comprising: i) first and second hydrophilic fibre-forming polymers which are soluble in the hydrophilic solvent, ii) a bioadhesive substance which is slightly soluble in said hydrophilic solvent, iv) a medicinal substance, in which the first hydrophilic polymer has water solubility at 37 °C, that, at least, is 10 times greater than solubility in water at 37 °C of second hydrophilic fibre-forming polymer, and in which bioadhesive substance is present in solid form. 
     EFFECT: disclosed is a pharmaceutical composition containing electrohydrodynamically produced fibres, a composition having improved retention time in the application site. 
     38 cl, 3 dwg, 12 tbl, 11 ex
Patent RU-2740905-C2 (RU)
Title: Питательный продукт для снижения уровней фенилаланина у больных фку
Inventor: ATTALI AMOS
IPC: A61K31/198
Filed: 2016-10-24
Granted: 2021-01-21
Abstract: Изобретение относится к лечению фенилкетонурии. Раскрыто применение композиции, включающей белок, липид и углеводы, где белок обеспечивает, по меньшей мере, все незаменимые аминокислоты, кроме фенилаланина, где липид включает одну или несколько ω-3 жирных кислот, выбранных из группы, состоящей из DHA, DPA и EPA, в общей концентрации по меньшей мере 0,05 мас.% от общего содержания липидов, и одно или несколько производных пиримидина, выбранных из группы, состоящей из источников уридина и источников цитидина, обеспечивающих от 0,4 до 3000 мг источника уридина, рассчитанного как монофосфат уридина на 100 ккал композиции, и/или от 0,4 до 3000 мг источника цитидина, рассчитанного как монофосфат цитидина на 100 ккал композиции, для снижения, нормализации или поддержания уровня фенилаланина в крови пациента с фенилкетонурией ниже 1200 мкмоль/л. Изобретение обеспечивает контроль уровней фенилаланина в крови больного фенилкетонурией. 21 з.п. ф-лы, 2 ил., 2 табл., 3 пр.
Patent RU-2754367-C2 (RU)
Inventor: KHAN MUHAMMAD-TANWEER
IPC: A61K35/74
Filed: 2016-10-28
Granted: 2021-09-01
Abstract: Предложенная группа изобретений относится к биотехнологии. Предложено применение бактерий штаммаFaecalibacterium prausnitziiи бактериального штаммаDesulfovibrio pigerдля лечения или предупреждения заболевания, ассоциированного с пониженным или низким числом бактерийFaecalibacterium prausnitzii,применение штаммаDesulfovibrio pigerпри лечении или предупреждении заболевания, ассоциированного с пониженными уровнями бутирата, где указанный штаммDesulfovibrio pigerимеет одну или несколько из характеристик из: (i) продуцирования ацетата, (ii) потребления лактата и (iii) наличия способности быть акцептором электронов и где указанный штаммDesulfovibrio pigerповышает продукцию бутирата в желудочно-кишечном тракте посредством синергетического действия штаммовDesulfovibrio pigerиFaecalibacterium prausnitzii, композиция для лечения предупреждения заболевания, ассоциированного с пониженными уровнями бутирата, или заболевания, ассоциированного с пониженным или низким числом бактерийFaecalibacterium prausnitzii, включающая штаммFaecalibacterium prausnitziiи бактериальный штаммDesulfovibrio pigerи набор, содержащийFaecalibacterium prausnitziiиDesulfovibrio piger, Группа изобретений позволяет повысить рост и колонизацию бактерий штаммаFaecalibacterium prausnitzii.6 н. и 15 з.п. ф-лы, 5 ил., 4 табл., 8 пр.
Patent RU-2749141-C2 (RU)
Title: OBTAINING Re-188/186 PARTICLES
Inventor: NIKULA TUOMO
IPC: G21G1/06
Filed: 2017-10-10
Granted: 2021-06-07
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to a method for producing activated particles containing 188Re isotopes and/or 186Re isotopes by neutron irradiation of non-volatile and water-insoluble starting particles containing a rhenium compound. In addition, the invention relates to obtaining corresponding non-volatile and water-insoluble starting particles and activated particles, as well as a composition containing multiple activated particles. In addition, the invention relates to obtaining corresponding non-volatile and water-insoluble starting particles and activated particles, as well as a composition containing multiple activated particles. Further, the precipitation of the said rhenium sulfide and the separation of particles containing precipitated rhenium sulfide is provided for.  
     EFFECT: activated particles and the composition containing them are suitable for use in radionuclide therapy and for cosmetic applications.  
     21 cl, 2 dwg
Patent RU-2753004-C2 (RU)
Title: System and method for positioning and controlling the aircraft as it moves along the taxiway
Inventor: STAUDINGER TAJLER K
IPC: G05D1/02
Filed: 2019-11-15
Granted: 2021-08-11
Abstract: FIELD: aviation.SUBSTANCE: group of inventions relates to a system and method for positioning and controlling an aircraft as it moves along a taxiway, a material non-short-term computer-readable information carrier. For positioning and controlling the aircraft, one or more processors access the model of a multi-channel neural network stored in the program memory, one or more processors receive multiple electronic images of parts of the taxiway from electronic imaging devices on the aircraft, data is processed to form an estimate of the lateral evasion of the aircraft as it moves along the taxiway. A material computer-readable carrier contains instructions for performing the method.EFFECT: invention provides an increase in the accuracy of the estimate of lateral evasion when controlling the aircraft on the taxiway.20 cl, 6 dwg
Patent RU-2740472-C2 (RU)
Inventor: Shevchenko Anton Alekseevich
IPC: H04N13/243
Filed: 2020-03-20
Granted: 2021-01-14
Abstract: FIELD: physics.SUBSTANCE: invention relates to the field of observation and visualization systems and to the method of forming the spheropanoramic field of view of the sighting and aiming devices. Method includes formation of spheropanoramic field of view of surveillance and aiming devices from closed objects and observation points with limited view by means of several microcircuits with dynamic memory, compactly and rigidly located relative to each other so that the detected by them parts of the image of the environment allow forming its spherical visualization. From the recorded parts of the image of the environment, spherical visualization is formed, the actual video segment of which is projected onto the display of the observer's monitor.EFFECT: technical result consists in enabling continuous spheropanoramic surveillance of the external environment, simple design and high reliability of the device.1 cl, 1 dwg
Patent RU-2770188-C2 (RU)
Title: Configuring resources for d2d communication, terminal device and network device
Inventor: TANG HAI
IPC: H04W72/04
Filed: 2018-07-27
Granted: 2022-04-14
Abstract: FIELD: communication.SUBSTANCE: invention relates to configuring resources for device-to-device communication (D2D). Resources are detected on at least one carrier by means of a terminal device based on the first set of parameters in order to obtain a set of available resources on this at least one carrier, wherein a resource in the set of available resources on each carrier can be used to transfer a target service. In this case, the first set of parameters contains at least one of: resource information for performing resource detection, a condition parameter for determining the set of available resources, and a parameter of the target service transfer. Then, information about the set of available resources on at least one carrier is transmitted via the terminal device to a network device. At the same time, an index of at least one potentially suitable target resource in the set of available resources on at least one carrier is reported to the network device.EFFECT: providing assistance to the network device in the efficient allocation of resources to the terminal device, while reducing mutual interference.12 cl, 9 dwg
Patent UA-56085-C2 (UA)
Title: Method of obtaining a preparation of placenta cell suspension
Inventor: LOBINTSEVA HALYNA STEPANIVNA
IPC: A01N1/02
Filed: 2002-11-08
Abstract: A method for obtaining a preparation of placenta cell suspension provides for washing the obtained placental tissue by means of perfusing through the umbilical vein with physiological solution, comminuting the placental tissue, multistage freezing in the solution, containing, as a cryopreserving agent, 10-20% solution of dimethylsulphoxide (DMSO) on the Henks' solution, submerging and preserving in liquid nitrogen. First, the placental tissue obtained is washed by sterile physiological solution with an antibiotic, then the perfusion is carried out, chorion and amniotic sac, as well as important blood vessels, are separated of the placenta. After comminuting the placental tissue is homogenized in physiological solution up to obtaining a creamy mass, the cryopreserving agent is added to the homogenate, they are mixed, poured into polyethylene ampoules, whereupon freezing is carried out.
Patent UA-73364-C2 (UA)
Title: A method for the preparation of 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone and a method for the preparation of intermediary compounds (variants)
Inventor: КUMAZAWA SATORU
IPC: C07C45/67
Filed: 2000-11-08
Abstract: A process for the preparation of 5-[(4-chlorophenyl)-methyl]-2,2-dimethylcyclopentanone which comprises reacting methyl 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclo-pentanecarboxylate or ethyl 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylate with sodium hydride and methyl halide and subjecting the obtained methyl 1-[(4-chloro-phenyl)methyl]-3,3-dimethyl-2-oxocyclopentanccarboxylate or ethyl 1-l(4-chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclo-pentanecarboxylate to hydrolysis. The process can give high-quality 5-[(4-chlorophenyl)-methyl]-2,2-dimethylcyclopentanone, an important intermediate for the production of metconazole which is a fungicide for agricultural and horticultural use, in a high yield through simple and easy operations.
Patent UA-63283-C2 (UA)
Title: Rod seal
Inventor: BOHUTA OLEKSANDR VASYLIOVYCH
IPC: F04B53/02
Filed: 2003-03-27
Abstract: A rod seal has chambers in which flat tightening and closing rings are placed, those are pressed in outer diameters with band springs, and protective (anti-extrusion) rings. In protective rings at end neighboring with sealing chambers support surfaces circular grooves are provided, those are connected to inter-chamber space by means of openings going from unloading grooves to outer surfaces of protective rings.
Patent UA-77404-C2 (UA)
Title: Norgestimate-based steroid hormone product and method for its manufacture
IPC: A61K9/14
Filed: 2001-12-13
Abstract: The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to methods for making such steroid hormone products, wherein a mixture of the hormone and the excipient is subjected to sufficient mechanical energy to form a powder blend wherein the hormone is stabilized by the excipient in substantially non-crystalline form.
Patent UA-80455-C2 (UA)
Title: Radiometric system for detecting gamma radiation and neutron radiation contains
Inventor: HRYNIOV BORYS VIKTOROVYCH
IPC: G01T3/00
Filed: 2005-06-21
Abstract: The proposed radiometric system for detecting gamma radiation and neutron radiation contains a gamma radiation detector, a neutron radiation detector, a power-supply unit, a signal processor, a control unit, a sound and light alarm unit, and a detector of a controlled object. The inputs of the control unit are connected to the outputs of the corresponding units of the system, and the output is connected to the input of the personal computer. The proposed system is distinctive by its enhanced sensitivity in the radiation energy range of 0.03 ... 0.3 MeV and its low threshold level in detecting radiation.
Patent UA-80865-C2 (UA)
Title: Method for transporting and cleaning tuberous roots and a device for carrying out thereof
Inventor: BULHAKOV VOLODYMYR MYKHAILOVYC
IPC: A01D91/00
Filed: 2005-10-10
Abstract: A method of transporting and cleaning tuberous roots includes transporting a heap, distributing thereof, delivering onto separating working elements, cleaning from soil and vegetation admixtures and removing the tuberous roots cleaned. In the period between the delivery onto various cleaning working elements a heap flow is consecutively divided in two mutually perpendicular planes and is simultaneously agitated and transported through vertical channels with gradual narrowing thereof. A device for transporting and cleaning tuberous roots consists of the base frame, a feeding conveyer, a baffle brush, an active cleaner, a finger blanket cleaner and an unloading conveyer. In front of the cleaner a heap divider is disposed, which represents two vertical transporting channels arranged above each other inside of which vertical rows of driven toothed wheels, the direction of rotation of which is forwarded downward, are arranged in mutually perpendicular planes,. The cross-section area of transporting channels is made with gradual lowering the transporting channels downwards.