baber/WOPTO huggingface dataset:
Patent NZ-510145-A (NZ)
Title: Branched alkyl pyrrolidine-3-carboxylic acids useful in protective action against cardiazole cramp and cerebral conditions such as epilepsy, hypokinesia and cranial traumas
Inventor: BRYANS JUSTIN STEPHEN
IPC: A61P1/00
Filed: 1999-08-11
Abstract: Branched alkyl pyrrolidines of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed. R1 is H or a straight or a branched C1-5alkyl; R2 is a straight or a branched C1-5alkyl; R1 and R2 togather form a carbocyclic ring having 3 to 7 atoms.
Patent NZ-510549-A (NZ)
Title: Low-smoke self-extinguishing electrical cable and flame-retardant composition used therein
Inventor: GRIZANTE REDONDO EDUARDO
IPC: C08L23/00
Filed: 1999-09-17
Abstract: Self-extinguishing cable coated with a flame-retardant composition comprising: (a) an ethylene homopolymer or copolymer having a density of from 0.905 to 0.970 g/cm3, and being selected from: ethylene homopolymers; copolymers of ethylene with an alpha-olefin; copolymers of ethylene with an ethylenically unsaturated ester; or mixtures thereof; (b) a copolymer of ethylene with at least one alpha-olefin, and optionally with a diene, said copolymer (b) having a density of from 0.860 to 0.904 g/cm3, and being characterized by a composition distribution index greater than 45 %; (c) natural magnesium hydroxide in an amount such as to impart flame-retardant properties; wherein at least one of the polymeric components (a) and (b) contains hydrolyzable organic silane groups grafted onto the polymer chain. The silane groups are preferably introduced during compounding of the flame-retardant composition by adding to the polymer mixture a suitable silane compound and a radical initiator.
Patent NZ-515686-A (NZ)
Title: A blocking monoclonal antibody to integrin VLA-1 and its use for the treatment of inflammatory disorders such as arthritis
Inventor: GOTWALS PHILIP
IPC: A61P/
Filed: 2000-06-01
Abstract: The use of a of an alpha1beta1 function blocking antibody which is capable of binding an epitope of integrin VLA-1 in a medicament for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. Figure 18. A. Increasing concentrations of the human alpha1-I domain were bound to plates previously coated with 1 µg/ml collagen I (squares) or collagen IV (circles). Values shown have been corrected for background binding to BSA. B. 2 µg/ml human alpha1-I domain was mixed with increasing concentration of an anti-human al integrin antibody SE8D9 (squares) or an antihuman alpha 2-integrin antibody A2IIE10 (circles), and then bound to plates previously coated with 1 µg/ml collagen IV. C. Plates were coated with 1 µg/ml collagen IV or 3% BSA. 1-I domain (2 µg/ml) was subsequently bound to coated plates in the presence of 1mM Mn2+, 1mM Mg2+, or 5 mM EDTA. Data shown is representative of three independent experiments.
Patent NZ-521840-A (NZ)
Title: Development of a multi-plasmid pol I - pol II based system for the generation of infectious influenza RNA viruses from cloned DNA
Inventor: HOFFMANN ERIC
IPC: A61P31/16
Filed: 2001-04-27
Abstract: Described is the development of a dual promoter system (preferably a RNA pol I -pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system is used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. The viral product of the system is produced when the plasmids of the system are introduced into a suitable non-human host cell. One application of the system is production of attenuated, reassortant influenza viruses for use as antigens in vaccines. The reassortant viruses generated by cotransfection of plasmids may comprise genes encoding the surface glycoproteins haemagglutinin and neuraminidase from an influenza virus currently infecting the population and the internal genes from an attenuated influenza virus. An advantageous property of the dual promoter system is its versatility; the system may be quickly and easily adapted to synthesize an attenuated version of any RNA virus. Attenuated or inactivated RNA viruses produced may be administered to a non-human patient in need of vaccination by any of several routes including intranasally or intramuscularly.
Patent NZ-522092-A (NZ)
Title: A superconducting transformer with concentrically interleaved windings
Inventor: DARMANN FRANCIS ANTHONY
IPC: H01F41/00
Filed: 2001-03-21
Abstract: A superconducting transformer includes two pairs of axially extending windings (1, 2, 3 and 4). The windings are each in the from of a right cylindrical solenoid having a circular cross-section which are substantially concentrically nested. Each winding (1, 2, 3 and 4) includes a plurality of turns formed from superconducting tape. Each winding respectively includes a first end and a second end (5 and 6, 7 and 8, 9 and 10, and 11 and 12) which are configured for electrical connection with at least one of the other ends, and alternating power source (13), a load (14), or other passive or active electrical components. The ampere turns of a first pair of the windings (1 and 3), is substantially the same as the ampere turns of a second pair of the windings (2 and 4).
Patent NZ-522360-A (NZ)
Title: Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses
Inventor: ROSIER-MONTUS MARIE-FRANCOISE
IPC: C12N15/09
Filed: 2001-05-02
Abstract: A nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. Also disclosed are, nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. Recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene are all also disclosed.
Patent NZ-523722-A (NZ)
Title: Polymorphs of an epothilone analog
Inventor: DIMARCO JOHN D
IPC: A61K31/00
Filed: 2001-08-01
Abstract: Disclosed are two crystalline polymorphs of the epothilone analog [1S-[1R*,3R*(E),7R*,10S*,11R*12R*,16S*]]-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione, shown as formula I. Processes for producing the polymorphs are disclosed, as are compositions containing the polymorphs for use in the treatment of cancer or other proliferative diseases in mammals.
Patent NZ-525548-A (NZ)
Title: Hand-held adhesive tape dispenser
Inventor: VULPITTA BRIAN A
IPC: B65H35/07
Filed: 2001-11-28
Abstract: A hand-held adhesive tape dispenser comprises a partial shell which has a support face and a peripheral wall (16) extending outwardly from the support face to form an open face housing. A spool of adhesive tape (20) is mounted on the support face through the use of a mounting structure on the shell which rotatably and detachably mounts the core (18) of the spool to the shell. The mounting structure includes spring fingers which snap over the core (18). An applicating end of the shell has a passage in its peripheral wall (16) located near a fixed guide and a cutter (44) at the applicating end so that the tape (20) removed from the core (18) would pass through the passage (38) around the guide to be applied to a substrate and then to be cut by the cutter from the remainder of tape.
Patent NZ-530375-A (NZ)
Title: Individual plant watering device
Inventor: AMSELLEM MAURICE
IPC: A01G27/00
Filed: 2002-07-01
Abstract: The invention concerns a fitting consisting of a part made of injected plastic for connecting a water tank (1) and a hollow cone (2) made of porous ceramics, so as to produce a device for dispensing water individually to plants, in particular potted plants, proximate to their roots, and in predetermined amount, comprising three coaxial parts: a disc-shaped intermediate part (4) with a central hole (5); a part (A) consisting of one or two cylinders, arranged on one side of the disc (4) and designed to be permanently fixed to the cone (2); a part (B) consisting like part A of one or two cylinders bearing a thread on the inner surfaces, arranged on the other side of the disc (4) and capable of receiving a bottle (1) removably screwed.
Patent NZ-530951-A (NZ)
Title: Pyrimidine derivatives having HIV replication inhibiting properties
Inventor: GUILLEMONT JEROME EMILE GEORGE
IPC: A61K/
Filed: 2002-08-09
Abstract: HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them are disclosed, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl, substituted C1-6alkyl, C1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O)pR6, -NH-S(=O)pR6, -C(=O)R6, -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R6, -C(=NH)R6 or a 5-membered heterocycle; X1 is -NR5-, -NH-NH-, -N=N-, -O-, -C(=O)-, C1-4alkanediyl, -CHOH-, -S-, -S(=O)p-, -X2-C1-4alkanediyl- or -C1-4alkanediyl-X2-; R3 is NHR13; NR13R14; -C(=O)-NHR13; -C(=O)-NR13R14; -C(=O)-R15; -CH=N-NH-C(=O)-R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; -C(=N-O-R8)-C1-4alkyl; R7; or -X3-R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino.
Patent NZ-533429-A (NZ)
Title: Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
Inventor: CHABRIER DE LASSAUNIERE PIERRE
IPC: A61P25/06
Filed: 2000-10-10
Abstract: Compounds of formula (I) which can be used for producing a medicament for inhibiting monoamine oxydases (MAO) and/or for lipidic peroxydation and/or for acting as modulators of sodium channels are disclosed, wherein Het is a 5-membered heterocycle comprising 2 heteroatoms and is such that general formula (I) corresponds exclusively to one of sub-formulae (I)1 and (I)2, wherein X is S and the other variables A, B, R1, R2, n and W are as defined in the specification. The resulting medicament is particularly suitable for treating Parkinson's disease, senile dementure, Alzheimer's disease, Huntington's chorea, amytrophic lateral sclerosis, schizophrenia, depression, psychosis, pain and epilepsy. (62) Divided out of 518304
Patent NZ-540021-A (NZ)
Title: Dispensing closure, or cap, for use on containers such as bottles
Inventor: SHARP JEFFREY JOHN
IPC: B67D99/00
Filed: 2005-05-16
Abstract: A dispensing closure, for a container such as a bottle 24, includes a storage chamber 2, a flexible diaphragm 3 and a membrane opening device 11 attached to the flexible diaphragm 3. The membrane opening device 11 includes a support structure in the form of an open structure through which a substance to be dispensed may flow and out through the opened membrane 5.
Patent NZ-540268-A (NZ)
Title: Intervertebral implant
Inventor: AEBI MAX
IPC: A61F2/44
Filed: 2002-12-17
Abstract: An intervertebral implant (1) characterised by the following: both parts (10; 20) can be displaced in relation to one another by means of two joints (38;39) that are located between the two parts; each of the joints has a rotational axis (3; 4) and the two rotational axes run transversally to one another; the two joints are configured by an upper joint section (31) that is connected to the upper part (10), a central joint section (32) and a lower joint section (33) that is connected to the lower part (20); one of the outer joint sections (31; 33) comprises at least one concave sliding surface (58) that is rotationally symmetrical in relation to the rotational axis; and the central joint part (32) comprises a convex sliding surface (57) that complements the concave sliding surface (58). The remaining outer joint part (31;33) comprises at least one convex sliding surface (55) that is rotationally symmetrical in relation to the other rotational axis and the central joint part comprises at least one concave sliding surface (56) that complements the convex sliding surface. The sliding surfaces are configured as partial surface areas of circular cylindrical or circular conical surface areas. The swivel axes are arranged skewed to each other.
Patent NZ-540719-A (NZ)
Title: Method for the prevention of malaria
Inventor: HOFFMAN STEPHEN L
IPC: A61K/
Filed: 2003-11-20
Abstract: Provided is the use of isolated, metabolically active, attenuated Plasmodium sporozoite parasites and a carrier in the manufacture of a pharmaceutical composition for stimulating an immune response and conferring protective immunity in mammalian and human hosts, wherein the medicament is formulated for parenteral, non-intravenous administration. Also provided is a composition comprising metabolically active attenuated Plasmodium sprorozoite parasites formulated for parenteral non-intravenous administration.
Patent NZ-540764-A (NZ)
Title: A method for identification, isolation and production of antigens to a specific pathogen
Inventor: MEINKE ANDREAS
IPC: C12Q1/68
Filed: 2002-01-21
Abstract: Provided is a hyperimmune serum-reactive antigen selected from the group consisting of: (a) a specific polypeptide, (b) a fragment of the polypeptide of (a) which is antigenic itself or antigenic when provided as a hapten; c) a fragment of (b) containing specified amino acid sequences and (c) a polypeptide or fragment of (a) to (c) with only a few amino acids changed. Provided are also corresponding pharmaceutical preparations and their use as vaccine against staphylococcal infections. Provided are also corresponding proteins and, methods for preparing antibodies against such proteins
Patent NZ-540851-A (NZ)
Title: Novel neomycin phosphotransferase genes and method for the selection of high-producing recombinant cells
Inventor: ENENKEL BARBARA
Filed: 2003-11-25
Abstract: Modified neomycin phosphotransferase genes and the use thereof in a selection method for high-producing recombinant cells. The invention also relates to expression vectors containing a modified neomycin phosphotransferase gene and a gene of interest in a functional bond with a heterologous promoter, and a method for producing heterologous gene products by using said expression vectors.
Patent NZ-541772-A (NZ)
Title: Thienopyrimidine compounds and use thereof
Inventor: CHO NOBUO
IPC: A61K31/519
Filed: 2004-01-28
Abstract: Disclosed is a compound of the formula I wherein R1 is C1-4alkyl; R3 is a C1-4alkyl; n is an integer of 1-4 and wherein the rest of the substituents are disclosed within the specification. Also disclosed is the use of the above compound as claimed in claim 1 for manufacturing a pharmaceutical composition for antagonizing gonadotrophin-releasing hormone. Also disclosed is the intermediate of formula II wherein the substituents are disclosed within the specification.
Patent NZ-542887-A (NZ)
Title: Preparation and purification of synthetic capsaicin
Inventor: MCILVAIN SHARON
IPC: A61K31/165
Filed: 2004-04-08
Abstract: Disclosed are methods for synthesizing the trans isomer of capasaicin and/or capasaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.
Patent NZ-544192-A (NZ)
Title: Sleeve splicing kit and method
Inventor: STAUDT ERIC K
IPC: F16L13/10
Filed: 2004-05-13
Abstract: A kit and a method for splicing together porous sleeves are disclosed. The kit includes a release liner in the form of a non-porous membrane, preferably in the shape of an elongated tube. Adhesive and an adhesive applicator may also be included. The method includes the steps of inserting the release liner within an end of a first sleeve and then inserting that sleeve end into the end of a second sleeve. The outer surface of the first sleeve engages the inner surface of the second sleeve and defines an engagement zone having a predetermined length. The release liner extends along the engagement zone. Adhesive is applied to the outer surface of the second sleeve. The adhesive penetrates the second sleeve and bonds it to the first sleeve. The release liner acts as a barrier preventing the adhesive from bonding the first sleeve closed at the splice.
Patent NZ-544702-A (NZ)
Title: A floating modular frame for an outdoor swimming pool
Inventor: FAY JOHN DEAN
Filed: 2006-01-13
Abstract: A modular frame, adapted to in use define a recreational area in a body of water 3, is disclosed. The frame 1 includes a plurality of connectable buoyant blocks 4, 4a, 4b. Each buoyant block is constructed of a plastic based foam, wherein each block includes at least one reinforcing member extending along at least one edge of the buoyant block.
Patent NZ-549716-A (NZ)
Title: Pyrimidin-dione derivatives as dipeptidyl peptidase inhibitors
Inventor: FENG JUN
IPC: C07D239/545
Filed: 2004-12-15
Abstract: Disclosed is a compound as pictured, wherein R3 is -NR10R11, and wherein the other substituents are as defined in the specification. Also disclosed is a process for preparing the compound, and its use in treating cancer, diabetes, autoimmune disorders, a condition characterized by inadequate lymphocyte or hemapoietic cell activation or concentration, HIV infection, or a condition characterized by immunodeficiency symptoms.
Patent NZ-549763-A (NZ)
Title: Machine and method for forming a package by applying a mandrel
Inventor: BACQUES JEAN-YVES
IPC: B31B50/52
Filed: 2005-02-10
Abstract: A machine for forming a package from a blank of sheet material including a bottom panel provided with lateral flaps having, in some cases, end tabs and forming side walls of the package, is disclosed. The machine includes: a bearing face for bearing on at least part of the surface of the bottom panel; a mandrel having an application face for applying the panel against the bearing face and retractable lateral faces delimited by edges; means for applying the mandrel against the bearing face; means for folding the lateral flaps and corresponding tabs against the opposed faces of the mandrel; and means for attaching together the flaps and tabs thus folded. The mandrel and its lateral faces are designed to be retractable between a first position for forming the package and a second position for withdrawing the mandrel from the package, thereby allowing the complete release of the walls of the package and its application face. The machine includes longitudinal and lateral stop means for the blank when the bottom panel is applied against the bearing face by the mandrel.
Patent NZ-556102-A (NZ)
Title: Partitions and components for partitions
Inventor: MCGOWAN NEIL DWAYNE
IPC: A47B96/04
Filed: 2007-06-22
Abstract: A screen is disclosed. The screen includes two or more panels, and one or more rails spanning the two or more panels along their top or bottom edges. The rails are formed as extrusions each having a recess in which the top or bottom edges of the panels are received. The outermost panels are retained at the ends of the rails by end caps secured to the ends of the rails and which close the recesses of the extrusions. Each end cap has an area corresponding to the cross-sectional area of the rail to which it is fitted such that the end edges of the outermost panels are not covered by the end caps but are exposed.
Patent NZ-565536-A (NZ)
Title: Pyrazolone derivatives as 11-beta HSD1 inhibitors
Inventor: AMREIN KURT
IPC: C07D231/20
Filed: 2006-08-21
Abstract: Disclosed are 1,2 - dihydro-pyrazol-3-ones of formula (I) wherein R1 is hydrogen, alkyl, cycloalkyI, cycloalkylalkyl, aralkyl, haloalkyl, aryl, pyridinylmethyl or heterocyclyl; R2 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, bcnzothiazolyl, bicyclo(2.2.1)heptyl or bicyclo(2.2.2)octyl or R1 and R2 together with the nitrogen atoms to which they are attached form pyrazolidine, hexahydro-pyridazine, (1,2)diazepane or 2,3,4,5, tetrahydro-1H-benzo(c)(1,2)diazepine, wherein pyrazolidine, hexahydro-pyridazine, (1,2)diazepane and 2,3,4,5, tetrahydro-1H-benzo(c)(1 ,2)diazepine; R3 is cyclopropyl or adamantanyl; R4 is hydrogen, alkyl, cycloalkyl, alkyloxyalkyl, alkylcarbonylaminoaryloxyalkyl, alkyloxyalkyl, aryl, aralkyl, haloalkyl or halocycloalkyl; or R3 and R4 together form -(CH2)n-; n is 3, 4, 5 or 6; and pharmaceutically acceptable salts and esters thereof. Also disclosed is a process to prepare said pyrazol-3-ones, compositions comprising said pyrazol-3-ones and the use of said pyrazol-3-ones for treating diabetes, obesity and hypertension.
Patent NZ-570515-A (NZ)
Title: Colour chart
Inventor: WARMAN KAREN
IPC: G09F5/04
Filed: 2008-08-14
Abstract: Disclosed is a foldable colour chart for displaying a selection of colours and an associated method of manufacturing the chart. The colour chart includes a card with a number of colour selections which are presented as colour chips on the card. A deformable area formed on the card and passes through each colour chip area. The deformable area, when bent, positions the colour chips at the edge of the bend.
Patent NZ-573554-A (NZ)
Title: A surface active ingredient composition
Inventor: DU PLESSIS ANDRIES
IPC: C09K23/08
Filed: 2007-05-28
Abstract: Disclosed herein is a surface active ingredient composition, which includes a base liquid including water which has dispersed therein in percentages by volume: Sodium chloride 1 to 3% Magnesium ions 1 to 2% Calcium ions 1 to 2% Potassium ions 1 to 2% Sulphate 1 to 2% Carbon 0.5 to 1% Nitrate 1 to 2% and Phosphate 1 to 2% Wherein the sodium chloride, if required, and sodium alkyl ether sulphate is dissolved in the base liquid, with the proportion of the base liquid to sodium chloride to sodium alkyl ether sulphate being between 1:1:1.5 and 1:1:5.
Patent NZ-577238-A (NZ)
Title: Novel triazinedione derivatives as gaba-b receptor modulators
Inventor: RIGUET ERIC
IPC: C07D405/10
Filed: 2007-11-09
Abstract: Provided is a compound of formula III, with defined substituents, which is a triazinedione derivative with GABAB receptor modulating activity. The compound is useful in preventing or treating central nervous system disorders, including eating and psychotic disorders.
Patent NZ-590197-A (NZ)
Title: Use of anti-CD8 antibodies to block activation of auto reactive T cells and generation of tolerogenic CD8 regulatory T-cells
Inventor: BANCHEREAU JACQUES F
IPC: A61K39/00
Filed: 2009-06-05
Abstract: Discloses the use of tolerogenic T cells in the manufacture of a composition to reduce transplant rejection in a transplant patient or for inducing immune tolerance to an antigen in a subject in need thereof. Further discloses methods to generate tolerogenic T cells. The tolerogenic T cells are the product of a method whereby: (i) previously isolated T cells or suppressor T cells are contacted with an amount of non-depleting anti-CD8 antibody during the T cell priming phase; (ii) the priming phase is carried out with addition of an antigen and with isolated dendritic cells obtained from monocytes cultured with GM-CSF and IFN-alpha-2b; (iii) wherein the T cell priming is effective to induce a tolerogenic T cell or suppressor T cell.