Patent EP-1673337-B1 (EP)
Inventor: ABOUABDELLAH AHMED
IPC: C07C271/48
Filed: 2004-10-01
Granted: 2011-11-23
Abstract: Arylalkylcarbamate esters (I) are new. Arylalkylcarbamate esters of formula (I) and their acid addition salts, hydrates and solvates are new. [Image] n : 1-6; A : X, Y and/or Z; X : 1-2C alkylene optionally substituted with 1-12C alkyl, 3-7C cycloalkyl or (3-7C)cycloalkyl(1-6C)alkyl; Y : vinylene (optionally substituted with 1-12C alkyl, 3-7C cycloalkyl or (3-7C)cycloalkyl(1-6C)alkyl) or ethynylene; Z : 3-7C cycloalkylidene or cycloalkylene; R 1H, halo, OH, CN, NO 2, 1-3C alkyl, 1-3C alkoxy, 1-3C alkylthio, 1-3C fluoroalkyl, 1-3C fluoroalkoxy or 1-3C fluoroalkylthio; R 2H, halo, OH, CN, NO 2, 1-3C alkyl, 1-3C alkoxy, 1-3C alkylthio, 1-3C fluoroalkyl, 1-3C fluoroalkoxy or 1-3C fluoroalkylthio, or phenyl, naphthyl, biphenylyl, phenylethylenyl, naphthylethylenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, indanyl, indenyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, cinnolinyl, thienyl, furanyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, triazolyl, benzothienyl, benzofuranyl, dibenzofuranyl, benzimidazolyl, benzotriazolyl, indolyl, isoindolyl, indazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, dihydroindolyl, pyrrolopyridinyl, furopyridinyl, thienopyridinyl, imidazopyridinyl, oxazolopyridinyl, thiazolopyridinyl, pyrazolopyridinyl, isoxazolopyridinyl, isothiazolopyridinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, phenyloxy, phenylthio, phenylsulfonyl, benzoyl, phenylmethoxy, phenylethoxy, phenylpropoxy, naphthalenyloxy, naphthalenylmethoxy, naphthalenylethoxy, naphthalenylpropoxy, quinolinoxy, isoquinolinoxy, all optionally substituted with halo, OH, CN, NO 2, 1-3C alkyl, 1-3C alkoxy, 1-3C alkylthio, 1-3C fluoroalkyl, 1-3C fluoroalkoxy, 1-3C fluoroalkylthio, phenoxy, benzyloxy, piperidinyl, pyrrolidinyl, morpholinyl, NH 2, NHR 6, NR 6R 7, NHCOR 6, COR 6, COOR 6, SO 2R 6, 1-3C alkylenedioxy or piperazinyl optionally substituted with 1-3C alkyl or benzyl; R 3CH 2CF 3 or phenyl optionally substituted with halo, CN, NO 2, 1-3C alkyl, 1-3C alkoxy, CF 3 or OCF 3; R 6, R 71-3C alkyl or phenyl. The following are excluded: 2,2,2-trifluoroethyl benzylcarbamate; 2,2,2-trifluoroethyl 4-methoxybenzylcarbamate; 4-nitrophenyl 2-(4-benzyloxyphenyl)ethylcarbamate; 4-chloro-2-nitrophenyl 2-(4-chlorophenyl)ethylcarbamate; 4-nitrophenyl 2-(3,4-dimethoxyphenyl)ethylcarbamate; phenyl 2-(3,4-dimethoxyphenyl)ethylcarbamate ; 4-cyanophenyl 2-(4-methylphenyl)ethylcarbamate; 2,4,5-trichlorophenyl 2-(4-chlorophenyl)ethylcarbamate; phenyl 4-chlorobenzylcarbamate; phenyl 4-methoxybenzylcarbamate; 4-fluorophenyl 2-(4-methoxyphenyl)ethylcarbamate; phenyl 3-nitrobenzylcarbamate; 4-cyanophenyl 4-methoxybenzylcarbamate; phenyl 3-chlorobenzylcarbamate; phenyl 3,4-dichlorobenzylcarbamate; 4-nitrophenyl 2-(4-hydroxyphenyl)ethylcarbamate; phenyl 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylcarbamate; phenyl 2-[4-(3-thienyl)phenyl]propylcarbamate; phenyl 2-[4-(2-amino-4-thiazolyl)phenyl]ethylcarbamate; 2,3,4,5,6-pentafluorophenyl 4-bromobenzylcarbamate. Independent claims are also included for: (1) two processes for preparing compounds (I); (2) pharmaceutical compositions comprising compounds (I), including those excluded above. ACTIVITY : Analgesic; Antiemetic; Neuroleptic; Tranquilizer; Antidepressant; Neuroprotective; Nootropic; Antiparkinsonian; Anticonvulsant; Nephrotropic; Cytostatic; Antiallergic; Dermatological; Antiparasitic; Virucide; Anti-HIV Antibacterial; Antiinflammatory; Antiarthritic; Antirheumatic; Antigout; Osteopathic; Ophthalmological; Antiulcer; Antidiarrheic; Uropathic. MECHANISM OF ACTION : Fatty acid amido hydrolase (FAAH) inhibitor. The most active compounds (unspecified) have IC50 values of 0.001-1 MicroM against FAAH activity.