baber/WOPTO huggingface dataset:
Patent WO-2019099873-A1 (WO)
Title: Traitement du cancer par dégradation de la signalisation double de mek
Inventor: HERGENROTHER PAUL J
IPC: A61P35/04
Filed: 2018-11-16
Abstract: La présente invention se rapporte à la découverte de kinases mutantes ou de fusion entraînant l'oncogenèse, et l'approbation ultérieure d'inhibiteurs spécifiques pour ces enzymes, qui a été instrumentale dans la gestion de certains cancers. Cependant, la résistance acquise reste un problème important sur le plan clinique, limitant l'efficacité à long terme de la plupart de ces médicaments. L'objet de la présente invention est de démontrer une stratégie permettant de surmonter cette résistance par clivage de MEK induit par un médicament (au moyen d'une activation directe de procaspase-3) combinée à une inhibition de kinase ciblée. L'effet de cette combinaison est montré d'une manière générale sur diverses histologies tumorales (mélanome, cancer du poumon et leucémie) et des mutations conductrices (BRAF ou EGFR mutant, kinases de Fusion EML4-ALK et BCR-ABL). La dégradation à médiation par caspase-3 des kinases MEK entraîne une inhibition de la voie soutenue et une résistance sensiblement retardée ou éliminée dans des cellules cancéreuses d'une manière supérieure à des combinaisons avec des inhibiteurs de MEK. Ces données suggèrent la généralité du clivage des kinases MEK à médiation par médicament en tant que stratégie thérapeutique permettant d'empêcher une résistance à des thérapies anticancéreuses ciblées.
Patent WO-2019152305-A1 (WO)
Title: Systems and methods for securing a sealing member on a filter assembly
Inventor: SHEWCHUK LUKE
IPC: B01D27/08
Filed: 2019-01-28
Abstract: A filter assembly comprises a filter housing defining an internal volume, a filter element positioned within the internal volume, and a gasket retainer. An outer edge of the gasket retainer is coupled to a top end of the filter housing, and an inner rim thereof forms a gasket retainer ledge. The filter assembly further comprises a retainer loop comprising a retainer loop main body. A plurality of retainer arms extend axially from the retainer loop main body towards the gasket retainer. Each of the plurality of retainer arms comprise a retainer arm ledge extending radially towards the retainer loop main body and snap-fit to the gasket retainer ledge. A retainer loop sidewall extends from the main body away from the gasket retainer. An outer surface of the retainer loop sidewall defines a curvature. A sealing member is removably positioned around the outer surface of the retainer loop sidewall.
Patent WO-2019178046-A1 (WO)
Title: Vacuum refining of molten glass
Inventor: WANG ZHONGMING
IPC: C03B5/225
Filed: 2019-03-12
Abstract: An apparatus (10) and method of refining molten glass are disclosed. An upstream vessel (12) contains molten glass, a downstream vessel (14) is arranged downstream of the upstream vessel, and vacuum refining vessels (16, 18) are located between the upstream vessel and the downstream vessel and are in separate, alternating fluid communication with the upstream vessel and in separate, alternating fluid communication with the downstream vessel.
Patent WO-2019245627-A1 (WO)
Inventor: ENGER ANDREW
IPC: E05B73/00
Filed: 2019-04-01
Abstract: A group lock box includes a box body and a door in which the door is shaped to have a recess that extends into an internal volume of the box body. The recess permits unique user locks that secure the door to the body to be partially received in the recess, which can make the locks not project as much from the outside of the box, thereby placing the locks closer to the center of gravity of the box. Among other things, this can make carrying the box with locks attached less unwieldy and can slim the overall profile of the group lock box with locks attached.
Patent WO-2019200337-A1 (WO)
Title: Aqueous adhesive compositions
Inventor: BULICK ALLEN
IPC: C09D133/14
Filed: 2019-04-12
Abstract: A latex emulsion that includes an aqueous carrier liquid and a latex copolymer formed from reactants comprising butyl methacrylate, wherein the reactants comprise at least 20 wt. % a vinyl monomer, based on the total weight of ethylenically unsaturated monomers in the latex copolymer. A homopolymer formed from the vinyl monomer preferably exhibits a glass transition temperature of between about -10 C and about 30 C. A coating formed from the latex emulsion preferably exhibits a dry adhesion of greater than about 4 pounds per linear inch when applied between a thermoplastic polyolefin roofing membrane and a plywood roofing substrate at an average coat weight of about 6 lbs/100 ft2 and subjected to 180 peel testing according to ASTM D903 with a 2-inch per minute pull rate. The latex emulsion may include a second latex copolymer or stage, and may be used as part of an aqueous adhesive composition.
Patent WO-2020214142-A1 (WO)
Inventor: NOTTINGHAM KYLE JAMES
IPC: G06F15/177
Filed: 2019-04-15
Abstract: An example configuration device can include a connection cable to be coupled to a port of a device positioned within a device package, wherein the connection cable is to provide electrical power to the device positioned within the device package and provide communication between the configuration device and the device positioned within the device package, and a computing device comprising instructions to: activate the device positioned within the device package through the connection cable, format the device positioned within the device package through the connection cable, and deactivate the device positioned within the device package through the connection cable.
Patent WO-2019236201-A1 (WO)
Title: Acknowledgement design for multi-transmission configuration indicator state transmission
Inventor: BAI TIANYANG
IPC: H04L1/18
Filed: 2019-04-19
Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may receive, during a transmission interval, a data transmission over a plurality of beamformed channels and, for each data transmission, a reference signal transmitted in conjunction with the data transmission. The UE may perform, for one or more of the plurality of beamformed channels, a channel state measurement procedure during the transmission interval using the data transmission, the reference signal, or a combination thereof. The UE may transmit, over an acknowledgement/negative acknowledgement (ACK/NACK) signal, a feedback report indicating a result of the channel state measurement procedure for the one or more of the plurality of beamformed channels. The base station may perform, based at least in part on the feedback report, subsequent transmissions to the UE over the one or more beamformed channels.
Patent WO-2019213104-A1 (WO)
Inventor: EIDSMORE PAUL
IPC: B60P1/64
Filed: 2019-04-30
Abstract: A loading/unloading system for an associated truck bed includes first and second laterally spaced rails configured for receipt in the associated truck bed. First and second support leg assemblies are operatively associated with the first and second rails, respectively. First and second motors are received on the first and second leg assemblies, respectively, and are configured to selectively raise and lower the first and second rails. A sensor assembly is mounted on the rails to monitor the position of the first rail relative to the second rail. The sensor assembly is interconnected to the first and second motors for maintaining the rails at the same height relative to one another.
Patent WO-2019217600-A1 (WO)
Title: Method for electronic detection and quantification of antibodies
Inventor: LINDSAY STUART
IPC: G01N33/487
Filed: 2019-05-08
Abstract: The present disclosure relates to a sensing device and methods for detecting, and quantifying the amount of, a target protein in a sample.
Patent WO-2020050884-A1 (WO)
Title: Temporal prediction shifting for scalable video coding
Inventor: HOROWITZ MICHAEL
IPC: H04N19/31
Filed: 2019-05-14
Abstract: A method (400) includes receiving an input video stream (120) and scaling the input video stream into two or more spatial layers (L). For each spatial layer, the method also includes generating a temporal layer prediction pattern (302) by: obtaining a temporal base layer (TL 0 ) for a corresponding spatial layer; identifying, based on the temporal base layer, a plurality of temporal layers (TL) and a plurality of temporal time slots (312, 314, 316, 318) during a temporal period (310); and aligning the temporal base layer for the corresponding spatial layer with one of the temporal time slots during the temporal period. Each temporal time slot is associated with one of the temporal base layer or one of the plurality of temporal layers for the corresponding spatial layer. The temporal base layer for each corresponding spatial layer is aligned with a different temporal time slot than each other temporal base layer.
Patent WO-2019222323-A1 (WO)
Title: Navigating congested environments with risk level sets
Inventor: PIERSON ALYSSA
IPC: G08G3/02
Filed: 2019-05-15
Abstract: A method is disclosed for use in a planning agent, the method including: identifying a first agent in a vicinity of the planning agent; identifying a location of the first agent and a velocity of the first agent; calculating a set of occupancy costs for the first agent, each occupancy cost in the set of occupancy costs being associated with a different respective location in the vicinity of the planning agent, each occupancy cost in the set of occupancy costs being calculated at least in part based on a cost function that depends on the location of the first agent and the velocity of the first agent; and changing at least one of speed or direction of travel of the planning agent based on the set of occupancy costs.
Patent WO-2020231428-A1 (WO)
Title: Self-adapting digital twins
Inventor: FILIPPOV ANDREY
IPC: G07C3/14
Filed: 2019-05-15
Abstract: A system and method can be used for implementing self-adapting digital twins. The system may include operations for estimate a state matrix characterizing behavior of a hydrocarbon recovery process implemented by a hydrocarbon recovery tool. Observed values of one or more sensors for at least one process parameter may be obtained from sensors deployed throughout the drilling environment. These sensors may be physical sensors acquiring information about physical changes within the drilling environment; and processes monitoring output of system functions and/or other processes. A data assimilation tool may be applied to the estimated state matrix and the observed values to produce an updated state matrix. The updated state matrix may be used as the previous state matrix in a subsequent time step, thus implementing a self-adapting digital twin model.
Patent WO-2019226496-A1 (WO)
Title: Universal electronic oven heating functionality module
Inventor: SHARPE ROGER
IPC: H05B6/66
Filed: 2019-05-17
Abstract: Universal electronic oven heating functionality modules and associated methods are disclosed herein. One such module includes an energy steering element, a controller with control logic for the energy steering element, a first means for forming a seal with an opening, and a casing to enclose the controller and the energy steering element. The casing can include top and bottom side elements. One such method includes providing a functionality module with a mounting plate, the first means for forming a seal, and the casing. The method also includes providing an electronic oven with a heating chamber and a second means for forming a seal with the functionality module. The heating chamber can have a first opening for a heating chamber door, and a second opening for functionality module reception. The method also includes engaging the functionality module with the heating chamber to form a seal between the first and second means.
Patent WO-2019232188-A1 (WO)
Title: Dosing regimen for the treatment of pi3k related disorders
Inventor: YELESWARAM KRISHNASWAMY
IPC: A61P35/00
Filed: 2019-05-30
Abstract: The present application provides methods of treating PI3Kδ related disorders using pyrazolopyrimidine derivatives.
Patent WO-2019246174-A1 (WO)
Title: Système et procédé d'enseignement de manipulation de symboles
Inventor: BUTLER ANDREW
IPC: G09B5/06
Filed: 2019-06-19
Abstract: L'invention concerne un système d'enseignement, comprenant une station d'accueil d'identification de symboles et une pluralité de matériels de manipulation de symboles, un dispositif informatique connecté à la station d'accueil d'identification de symboles, et une base de données, la base de données comprenant des données lexicales et un curriculum d'apprentissage adaptatif.
Patent WO-2020263243-A1 (WO)
Title: Appareil ayant une poignée et des vessies de gonflage
Inventor: GHOSH SARTHAK
IPC: A61B5/0205
Filed: 2019-06-26
Abstract: Dans certains exemples, un appareil peut comprendre une poignée ayant une première surface et une seconde surface, une vessie gonflable située sur la seconde surface, et un capteur situé sur l'appareil, le gonflage de la vessie gonflable amenant le capteur à être en contact avec une surface externe d'un utilisateur de l'appareil.
Patent WO-2020006104-A1 (WO)
Inventor: OSBY JOHN O
IPC: C08F210/02
Filed: 2019-06-26
Abstract: L'invention concerne un polymère à base d'éthylène formé par réaction d'au moins les éléments suivants : éthylène et au moins un polyène asymétrique, de structure 1, tel que décrit ici.
Patent WO-2020014207-A1 (WO)
Title: Systems for sensing presence of medical tools
Inventor: POLONSKY ANDREY
IPC: A61M25/01
Filed: 2019-07-09
Abstract: A system including a tool recognition assembly comprising a first target reader with a first detection zone. The system also includes a tool configured to be installed in the tool recognition assembly, wherein the first reader detects a first reading indicating a presence or absence of the first target in the first detection zone during an installation of the tool in the tool recognition assembly, the detected first reading being at least a part of a detected insertion signature, and provides the detected insertion signature to initiate a comparison of the detected insertion signature to one or more model signatures.
Patent WO-2020028180-A1 (WO)
Title: Specific detection of ribonucleic acid sequences using novel crispr enzyme-mediated detection strategies
Inventor: BAUGHMAN TED A
IPC: C12Q1/66
Filed: 2019-07-26
Abstract: Embodiments disclosed herein include devices, methods, and systems for direct, selective, and sensitive detection of single-stranded target RNA sequences from various sources using a programed Cas13a protein. When activated by binding a target RNA sequence, the Cas13a cleaves a tether releasing a reporter molecule that may then be detected. In some embodiments, the systems, methods, and devices may include a filter or membrane that may help to separate the tethered and untethered reporter molecules. These devices, systems, and techniques allow a user to rapidly process samples that may contain the target RNA, without needing to amplify the target sequences. These devices and methods may be used to assay a wide variety of samples and target RNA sources, for the presence or absence of a specific target RNA sequence. Compositions and kits, useful in practicing these methods, for example detecting a target RNA in a biological sample, are also described.
Patent WO-2020047375-A1 (WO)
Title: Thermal management system
Inventor: ULAVI TEJAS
IPC: H01L21/324
Filed: 2019-08-30
Abstract: A thermal management system comprising a fluid channel with a plurality of parallel first flow paths extending along a first level in a first thermal mass and a plurality of parallel second flow paths extending along a second level in a second thermal mass are described. Methods for controlling the temperature of a substrate or heater surface and fluid manifolds are also described.
Patent WO-2020068774-A1 (WO)
Title: System and method for the development of cd30 bispecific antibodies for immunotherapy of cd30+ malignancies
Inventor: MEDIN JEFFREY
IPC: C07K16/28
Filed: 2019-09-24
Abstract: The present invention provides novel bispecific antibodies that bind to human CD30 and uses thereof. Methods of treating cancer using the bispecific antibodies described herein are also provided.
Patent WO-2020068790-A1 (WO)
Title: Conversational agent pipeline trained on synthetic data
Inventor: AREL ITAMAR
IPC: G10L15/06
Filed: 2019-09-24
Abstract: In one embodiment synthetic training data items are generated, each comprising a) a textual representation of a synthetic sentence and b) one or more transcodes of the synthetic sentence comprising one or more actions and one or more entities associated with the one or more actions. For each synthetic training data item, the textual representation of the synthetic sentence is converted into a sequence of phonemes that represent the synthetic sentence. A first machine learning model is then trained as a transcoder that determines transcodes comprising actions and associated entities from sequences of phonemes, wherein the training is performed using a first training dataset comprising the plurality of synthetic training data items that comprise a) sequences phonemes that represent synthetic sentences and b) transcodes of the synthetic sentences. The transcoder may be used in a conversational agent.
Patent WO-2020081212-A1 (WO)
Title: Oligomerization of olefins
Inventor: LI SHIWEN
IPC: C07C45/50
Filed: 2019-09-26
Abstract: A process for olefin oligomerization can include contacting a feedstock comprising C n  and C 2n  olefins/paraffins under oligomerization conditions in the presence of an oligomerization catalyst, wherein n is 2 to 15; and recovering an oligomeric product comprising C 3n  oligomers having a branching index of less than 2.1. Optionally, the feedstock can further comprise C 3n  olefins/paraffins.
Patent WO-2020072303-A1 (WO)
Title: Systems and methods for maintaining constant volumetric flow rates in a fluid channel
Inventor: HOMYK ANDREW
IPC: B01L3/00
Filed: 2019-09-27
Abstract: Disclosed herein are systems and methods capable of identifying, tracking, and sorting particles flowing in a channel, for example, a microfluidic channel having a fluid medium. The channel and the fluid medium can have a similar refractive index such that they appear translucent or transparent when illuminated by electromagnetic radiation. The particles can have a refractive index substantially different from that of the channel and the medium, such that the particles interfere with the electromagnetic radiation. A sensor can be disposed adjacent to the channel to record the electromagnetic radiation. The sensor can be used for identifying, tracking, and sorting the particles.
Patent WO-2020097118-A1 (WO)
Title: Method of making fuel cells and a fuel cell stack
IPC: B33Y80/00
Filed: 2019-11-05
Abstract: Herein discussed is a method of making a fuel cell comprising (a) producing an anode using an additive manufacturing machine (AMM); (b) creating an electrolyte using the additive manufacturing machine; and (c) making a cathode using the additive manufacturing machine. In an embodiment, the anode, the electrolyte, and the cathode are assembled into a fuel cell utilizing the additive manufacturing machine. In an embodiment, the fuel cell is formed using only the additive manufacturing machine.
Patent WO-2020185266-A1 (WO)
Inventor: HILDEBRAND DEAN
IPC: G06F11/20
Filed: 2019-11-22
Abstract: A secondary pool of VMs is used to run secondary services or jobs, which may be evicted upon failure of a corresponding primary VM. Upon detection of a failure of a primary resource, the secondary services or jobs are evicted from secondary pool resources, and the secondary pool resources can be automatically allocated to the jobs of the failed primary resource. In this regard, a secondary job may be thought of as a preemptible job and comprises services or jobs that are lower priority than the service or job on the primary resource. By using computing resources in the secondary pool to run secondary or preemptible jobs, this technology makes use of what would be otherwise idle resources, This beneficially avoids having to allocate additional and separate computing resources for secondary jobs, leads to more efficient use of network resources, and reduces costs.
Patent WO-2020149956-A1 (WO)
Inventor: WALDERN JONATHAN
IPC: G02B27/00
Filed: 2019-12-05
Abstract: L'invention concerne des guides d'ondes et des affichages de guide d'ondes ayant une couche pour bloquer une lumière non-image (c'est-à-dire un trouble) qui pourraient autrement réduire le contraste et dégrader la gamme de couleurs et l'uniformité, tout en fournissant une transmission élevée à la lumière externe. De nombreux guides d'ondes et affichages incorporent au moins une couche de commande de lumière appliquée à au moins une surface externe dudit guide d'ondes et chevauchant au moins une partie dudit au moins un réseau, pour dévier ou bloquer la lumière diffusée à partir dudit ensemble de réseaux qui pourraient autrement entrer dans ladite région oculaire.
Patent WO-2020146393-A1 (WO)
Inventor: SCHREIBER TAYLOR
IPC: C12N15/85
Filed: 2020-01-07
Abstract: The present technology relates, inter alia, to compositions and methods, including heterodimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Patent WO-2020154186-A1 (WO)
Inventor: KIMCHI GUR
IPC: B64C29/00
Filed: 2020-01-17
Abstract: L'invention concerne des systèmes et des procédés conçus pour réduire la traînée aérodynamique et/ou affecter des caractéristiques de vol d'un véhicule aérien et pouvant comprendre des carénages réglables (103-1) associés à un ou plusieurs composants du véhicule aérien. Les carénages réglables (103-1) peuvent être couplés à, et entourer au moins partiellement, un moteur, un mécanisme de propulsion, un bras de moteur, une entretoise ou un autre composant d'un véhicule aérien. De plus, les carénages réglables (103-1) peuvent être mobiles de manière passive entre deux positions ou plus en réponse à un écoulement d'air autour des carénages, et/ou les carénages réglables peuvent être activement déplacés entre deux autres positions pour affecter des caractéristiques de vol. En outre, les carénages réglables (103-1) peuvent comprendre des éléments actionnables pour modifier une partie d'une surface externe des carénages pour ainsi affecter des caractéristiques de vol. De cette manière, des carénages réglables associés à divers composants d'un véhicule aérien peuvent réduire la traînée aérodynamique et/ou peuvent améliorer la commande et la sécurité d'un véhicule aérien.
Patent WO-2020180447-A1 (WO)
Title: Electro-hydraulic arrangement for an earthmoving machine
Inventor: FERRAZ JOHN
IPC: E02F3/84
Filed: 2020-02-06
Abstract: An electro-hydraulic arrangement (310) for controlling operation of a pair of tilt actuators (112, 114) of an earthmoving machine (100) includes a housing (312), and a directional control valve (DCV) (314) and a regeneration valve (RV) (316 disposed within the housing (312). The DCV (314) and the RV are coupled in selective fluid communication with one another and with rod end and head end chambers (116, 118) of the actuators via ports defined on the housing (312). When the DCV (314) is in a first or second operative position, the RV may be positioned in a regenerative position to allow the rod end chambers (116) of respective ones of the first and second actuators (112, 114) to communicate fluid to the head end chamber (118) of the second actuator (114). Optionally, the regen valve may be positioned in a drain position to allow the rod end chambers (116) of respective ones of the first and second actuators (112, 114) to communicate fluid with the drain port (346) of the housing (312).