baber/WOPTO huggingface dataset:
Patent CA-3153099-A1 (CA)
Inventor: REEDER THADD
IPC: A61K31/5415
Filed: 2020-09-17
Abstract: La présente invention concerne des méthodes de traitement et/ou de prévention de symptômes de l'épilepsie ou de l'encéphalopathie épileptique dans lesquelles la fenfluramine ou un sel pharmaceutiquement acceptable de celle-ci est ou a été administré à un patient ou à une population de patients. La présente invention concerne une reconnaissance de contre-indication de la fenfluramine et de certains agonistes du récepteur de la sérotonine, notamment un antagoniste du récepteur de la sérotonine pénétrant dans le SNC. La présente invention concerne des méthodes dans lesquelles lesdits patients ayant reçu de la fenfluramine ont été prévenus contre la co-administration de certains antagonistes du récepteur de la sérotonine, ne sont pas co-administrés avec un antagoniste du récepteur de la sérotonine et/ou dans lesquels la co-administration d'un antagoniste du récepteur de la sérotonine est interrompue.
Patent CA-3153978-A1 (CA)
Inventor: KREMER HARTMUT
IPC: C04B38/08
Filed: 2020-09-23
Abstract: L'invention concerne un procédé de production d'un matériau granulaire expansé à partir d'un matériau minéral de type grain de sable comprenant un agent d'expansion lié, par exemple pour la production d'un matériau granulaire expansé à partir de sable de perlite. Le matériau minéral de type grain de sable est introduit dans une ouverture d'alimentation à une extrémité d'une cuve de four, transporté le long d'une section de traitement thermique dans une direction de transport, de préférence par gravité, et chauffé à une température critique tout en étant transporté à travers la section de traitement thermique, le matériau minéral de type grain de sable se plastifiant à partir de ladite température et commençant à s'expanser sous l'effet de l'agent d'expansion, et le matériau granulaire expansé est évacué à l'autre extrémité de la cuve du four. Le but de l'invention est d'améliorer la polyvalence du matériau granulaire expansé. Selon l'invention, l'objectif est atteint en ce que le matériau minéral de type grain de sable est chauffé à une deuxième température supérieure à la température critique après avoir été chauffé à la température critique, ladite deuxième température étant inférieure à une troisième température à laquelle la surface du matériau granulaire expansé éclate, et en ce que la deuxième température est sélectionnée sur la base d'une densité souhaitée du matériau granulaire expansé de sorte qu'une partie de l'agent d'expansion reste lié dans le matériau granulaire.
Patent CA-3155573-A1 (CA)
Inventor: BACHMAN NATHAN J
IPC: B60K15/03
Filed: 2020-11-06
Abstract: The invention relates to the use of a low Tg compatible resin as an adhesive layer for the welding of a thermoplastic composite structure to a thermoplastic or thermoset structure. The invention is especially good for the welding of large parts, such as wind turbine halves and spar caps. A useful thermoplastic composite is one formed by the infusion and curing of long fibers by a reactive acrylic liquid resin system, such as ELIUM® resin systems from Arkema.
Patent CA-3155905-A1 (CA)
Title: Bioartificial pancreas
Inventor: PHOTIADIS SARA JOAN
IPC: A61K51/06
Filed: 2020-09-24
Abstract: A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.
Patent CA-3156896-A1 (CA)
Title: Devices and methods for applying a hemostatic clip assembly
Inventor: BARENBOYM MICHAEL
IPC: A61B17/08
Filed: 2020-11-02
Abstract: A device for applying a hemostatic clip assembly includes a proximal delivery catheter having a handle assembly and an elongated catheter body defining a longitudinal axis extending distally from the handle assembly, and a distal clip assembly removably connected to a distal end of the catheter body. The distal clip assembly includes a distal clip housing, a jaw assembly and a jaw adapter yoke. The jaw assembly has a pair of jaw members fixed to the distal clip housing by a first pin oriented orthogonally relative to the longitudinal axis. The jaw adapter yoke is operatively connected to the jaw members. The proximal delivery catheter is configured to transmit linear motion along and torsion about the longitudinal axis to at least a portion of the distal clip assembly. At least one of the jaw members is configured to rotate about the first pin between an open and a closed configuration.
Patent CA-3159285-A1 (CA)
Inventor: KUBIAK BARTLOMIEJ
IPC: A61K9/00
Filed: 2020-12-06
Abstract: The present invention relates to a liquid pharmaceutical composition comprising cytisine, at least one inorganic pH-regulating agent selected from the group consisting of inorganic acids, inorganic buffers, and inorganic acid salts, and water, wherein the liquid pharmaceutical composition has a pH value between 3.0 and 7.5. The present invention furthermore relates to the liquid pharmaceutical composition for use in the treatment of tobacco smoking addiction and other forms of nicotine addiction. Additionally, the invention relates to a liquid pharmaceutical composition comprising cytisine for oral use in the treatment of tobacco smoking addiction and other forms of nicotine addiction.
Patent CA-3159655-A1 (CA)
Title: Diimine metal complex, preparation method therefor, and application thereof
Inventor: GAO RONG
IPC: C07F15/04
Filed: 2020-10-30
Abstract: The present invention relates to a diimine metal complex represented by formula I, a preparation method therefor, and application thereof. The complex is used as a main catalyst in catalysts for olefin polymerization, and can achieve catalytic ethylene polymerization at a high temperature to prepare high molecular weight branched polyethylene.
Patent CA-3161497-A1 (CA)
Title: Pde4 inhibitors, pharmaceutical compositions, and therapeutic applications
Inventor: CHAN KYLE W H
IPC: C07D401/14
Filed: 2020-12-14
Abstract: Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.
Patent CA-3161802-A1 (CA)
Title: Procedes d'amelioration et d'acceleration de l'expression d'anticorps
Inventor: NGO KATHY
IPC: C12N9/22
Filed: 2020-12-15
Abstract: La présente demande concerne des cellules, des systèmes et des procédés d'ingénierie moléculaire utilisant des complexes CRISPR/Cas pour l'activation ciblée d'éléments régulateurs transcriptionnels endogènes maîtres (MTRE), tels que PRDM1, XBP1 et IRF4, en vue de l'obtention d'une production d'anticorps à productivité élevée dans des lignées cellulaires de production telles que les cellules CHO et NSO. Cela comprend l'inclusion des protéines accessoires Cas, la conception de multiples ARN guides (ARNg) et le multiplexage unique de ces composants par le biais, par exemple, d'une transfection lentivirale pour induire une transcription et une traduction accrues de gènes d'anticorps sous le contrôle des MTRE. Les procédés conduisent à des synergies augmentant la production d'anticorps monoclonaux par ces lignées cellulaires modifiées. Tandis qu'une augmentation significative de la productivité est démontrée par ce procédé d'activation, une augmentation supplémentaire de la productivité peut être obtenue par transfert génétique de copies supplémentaires de MTRE.
Patent CA-3162474-A1 (CA)
Inventor: HUANG YUAN-HSIAO
IPC: G01N1/28
Filed: 2022-06-10
Abstract: Matrix-assisted methods and compositions for solidifying and preparing liquid biopsies and other liquid samples for three-dimensional high-resolution imaging and diagnostics by microscopy.
Patent CA-3163281-A1 (CA)
Inventor: YUAN PENGFEI
IPC: A61K48/00
Filed: 2020-12-31
Abstract: Provided is a method for deaminating targeted cytosine in a target RNA of a cell. The method comprises: introducing, into the cell, a modified adenosine deaminase protein or a catalytic domain thereof, or a construct expressing the modified adenosine deaminase protein or the catalytic domain thereof, and a construct comprising an arRNA oligonucleotide that recruits the modified adenosine deaminase protein or the catalytic domain thereof to the target RNA or expressing arRNA. Further provided are an engineered composition or system for RNA editing, and the use of treating a disease by using the engineered composition or the system to correct T-C mutation.
Patent CA-3163765-A1 (CA)
Inventor: MENG XIANGLING
IPC: G06N20/00
Filed: 2022-06-17
Abstract: Systems and methods of subscriber retention analysis are disclosed. A system is configured to obtain an instance of a current subscriber data for the first current subscriber subscribed to a product for a first amount of time and configured to provide the first instance of the current subscriber data to a machine learning (ML) classification model. Training the ML classification model is based on a plurality of data sets as training data. Each data set includes an instance of historic subscriber data over the first amount of time of a subscription for a historic subscriber. The system is also configured to generate, using the ML classification model, a predicted likelihood in retaining the first current subscriber based on the first instance of the current subscriber data.
Patent CA-3164444-A1 (CA)
Title: Produit proteique vegetal texture et procede
Inventor: OLATUNDE GBENGA
IPC: A23J3/26
Filed: 2020-12-14
Abstract: L'invention concerne un procédé de production de produits protéiques végétaux texturés à l'aide d'un mélange d'au moins une protéine végétale et de transglutaminase. Le procédé fournit un moyen pour former des produits protéiques à base de pois texturés, par exemple, qui peuvent être utilisés dans une large gamme d'applications, en particulier dans des produits alimentaires comprenant des substituts de viande végans.
Patent CA-3166803-A1 (CA)
Inventor: ELIASON WILLIAM
IPC: C04B28/04
Filed: 2021-02-03
Abstract: Disclosed herein are paver adhesives including dry concrete mixes. The paver adhesive can include cement, silica sand, alumina silicate, and latex or acrylic polymer. The paver adhesive can be configured to be applied to a substrate in a dry state. The paver adhesive can be configured to become hydrated subsequent to pavers being installed over the paver adhesive, and the paver adhesive can be configured to cure and adhere paver tiles to the substrate following the hydrating.
Patent CA-3168935-A1 (CA)
Title: Ventilated aerosol-generating article with upstream porous segment
Inventor: BERTOLDO MASSIMILIANO
IPC: A24D1/20
Filed: 2021-02-24
Abstract: There is provided an aerosol-generating article (10) comprising: a rod (12) of aerosol-generating substrate; and a downstream section (14) at a location downstream of the rod (12) of aerosol-generating substrate. The downstream section (14) comprises: a support element (22) located immediately downstream of the rod (12), the support element (12) being in longitudinal alignment with the rod (12) and comprising a first hollow tubular segment (26); and an aerosol cooling element (24) located immediately downstream of the support element (22), the aerosol-cooling element (24) being in longitudinal alignment with the support element (22) and the rod (12) and comprising a second hollow tubular segment (34). The aerosol-generating article (10) further comprises a ventilation zone (60) at a location along the second hollow tubular segment (34), and an upstream section (16) at a location upstream of the rod (12). The upstream section (16) comprises an upstream element (46) positioned immediately upstream of the rod (12) of aerosol-generating substrate and having a resistance to draw (RTD) of less than about 50 millimetres H2O.
Patent CA-3169686-A1 (CA)
Inventor: DEL TIN LAURA
IPC: H01J37/10
Filed: 2021-02-18
Abstract: Disclosed herein is a manipulator lensing device for focusing a beam of charged particles, wherein the manipulator lensing device comprises a first structure (401) through which is formed an opening, wherein the path of the beam is substantially along a longitudinal axis of the opening, a second structure (402) with a surface (406) surrounding the opening, a support (403) that connects the second structure to the first structure and surrounds the second structure, and an electrode arrangement (407) provided on the surface (406) of the second structure, wherein a first surface (404) of the first structure (401) surrounds the opening, a second surface (405) of the first structure (401) surrounds the opening, the surface (406) of the second structure (402) being arranged along the longitudinal axis between the first and second surfaces of the first structure, the electrode arrangement (407) and each of the first (404) and second (405) surfaces of the first structure (401) are separated from each other by a respective gap in a direction parallel to the longitudinal axis, wherein, along the longitudinal axis, the extent of the support (403) is less than the extent of the surface (406) of the second structure and/or electrode arrangement (407). Further disclosed is a multi-array lens configured focus a plurality of beamlets of charged particles along a multi-beam path, wherein each lens in the array comprises said manipulator lensing device.
Patent CA-3170167-A1 (CA)
Inventor: Buddi Sai Prasad
IPC: A61B5/021
Filed: 2021-02-19
Abstract: A hemodynamic monitoring system monitors arterial blood pressure of a patient and provides a warning to medical personnel of a predicted future hypotension event of the patient. Sensed hemodynamic data representative of an arterial pressure waveform of the patient are received by a hemodynamic monitor. The received hemodynamic data is offset, based on a difference between a standard mean arterial pressure (MAP) threshold for hypotension and an adjusted MAP threshold for hypotension, to produce adjusted hemodynamic data. Waveform analysis of the adjusted hemodynamic data is performed, and a risk score representing a probability of a future hypotension event for the patient is determined based on the waveform analysis. A sensory alarm is invoked to produce a sensory signal in response to the risk score satisfying a predetermined risk criterion.
Patent CA-3170850-A1 (CA)
Title: System and method of operating multi-engine system
Inventor: BEAUCHESNE-MARTEL PHILIPPE
IPC: B64D31/00
Filed: 2022-08-19
Abstract: There is described a method of operating a multi-engine system of an helicopter. The multi-engine system has a first turboshaft engine having a first shaft, a second turboshaft engine having a second shaft, a gearbox having a clutch system, and a range of rotation speeds defined as a placarded zone. The method generally has: rotating the first and second shafts at a flight rotation speed above the placarded zone when clutched to a load; decreasing a rotation speed of the first shaft from the flight rotation speed to a first idle rotation speed above the placarded zone; unclutching the first shaft from the load during the decreasing; and subsequently to the decreasing and the unclutching, simultaneously decreasing the rotation speeds of the first shaft and of the second shaft to a second idle rotation speed below the placarded zone, the simultaneously decreasing including clutching the first shaft to the load.
Patent CA-3174367-A1 (CA)
Inventor: FARKAS NICHOLAS
IPC: B29C48/16
Filed: 2022-07-19
Abstract: The disclosure provides ethylene/?-olefin interpolymer and/or copolymer based co-extruded, multi-layer films, including high barrier films and non-barrier films, and articles of manufacture that include the films, such as flexible bags and containers for flowable materials. The films and articles that include the films have good flex-crak resistance and toughness. The films and articles that include the films have good high barrier properties as the barrier films include a core layer of ethylene-vinyl alcohol (EVOH) copolymer. The relatively low amount of EVOH copolymer in the total film that is needed to achieve the flex-crack resistance, toughness, and high barrier properties, further allow for the recycling of the films and articles of manufacture.
Patent CA-3177070-A1 (CA)
Title: Vending machine system
Inventor: DONAGHEY ANDREW
IPC: G06Q20/32
Filed: 2021-04-27
Abstract: A method for remotely controlling a CO2 gas cylinder vending machine system, the method including: displaying a remote vending machine user interface on a display of a user device; receiving on the user device user input indicating a desire to engage with the vending machine system to perform at least one of the following operations: (a) return a CO2 cylinder; (b) purchase a CO2 cylinder; or (c) exchange a CO2 cylinder; transmitting the user input over a communications network to a communications interface of the vending machine system; receiving the user input at the communication interface of the vending machine system; and controlling the vending machine system, by a controller, based on the received user input.
Patent CA-3177640-A1 (CA)
Inventor: WEBER DANIEL
IPC: G05B11/14
Filed: 2021-02-22
Abstract: L'invention concerne un système et un procédé permettant le réglage/la configuration automatique d'un stabilisateur de système de puissance (PSS) dans un système de commande d'excitation numérique de système de puissance comportant un régulateur de tension automatique (AVR) qui comprend la fourniture d'une entrée de commande à l'AVR en fonction de la génération d'un ensemble de constantes de temps de compensation de phase avance-retard du PSS de réglage en fonction des tensions de borne générées reçues, la génération d'une réponse de fréquence non compensée en fonction de l'ensemble reçu de tensions de borne générées et l'utilisation d'une optimisation par essaim de particules (OEP) en fonction de la réponse en fréquence non compensée générée, la génération d'une valeur de gain de PSS de réglage en fonction d'une réponse en fréquence en boucle ouverte déterminée du système de puissance, la détermination d'une marge de gain de PSS, la détermination d'un gain de PSS de réglage; et la transmission de l'ensemble déterminé de constantes de temps de compensation de phase de réglage et de la valeur de gain de PSS de réglage déterminée à l'interface de commande du PSS.
Patent CA-3179698-A1 (CA)
Inventor: RIVEROS CARLOS ALBERTO
IPC: A61K31/133
Filed: 2021-05-21
Abstract: A system, method, use, combination and kits useful in the administration of a certain medication for reducing viral replication of certain viruses during the early stage of transmission or as a prophylaxis when high risk of exposure to a virus is detected or predicted, administering efficiently a high local concentration of the certain medication while minimizing systemic exposure. Specifically it refers to a system, a method, a use, pharmaceutical combination and pharmaceutical kits of a certain nebulized medication to reduce viral replication. The development uses inhalers or nebulizers to deliver at least one certain medication directly into the upper and lower airways mucosae.
Patent CA-3179703-A1 (CA)
Title: Membranes for medical devices
Inventor: BURCEZ CHARLES-THIBAULT
IPC: A61L27/54
Filed: 2021-04-08
Abstract: The invention relates to an implantable chamber comprising a closed shell made of a permeable membrane, said membrane comprising at least one layer of porous biocompatible polymer, with pores controlled and homogeneously distributed over the membrane.
Patent CA-3179865-A1 (CA)
Inventor: MCKINLEY ROBERT E
IPC: B23B51/00
Filed: 2021-04-12
Abstract: There is provided a drill tool assembly for drilling metallic or other materials, comprising a holder having a mounting slot in which a cutting insert is positioned, and a through tool coolant supply system. The drilling tool system allows for the application of coolant to the rake surfaces of the cutting insert in a manner which facilitates enabling higher penetration rates while maintaining integrity of the cutting edges of the cutting insert. The drilling tool system comprises a holder having a rotational axis and mounting slot. A cutting insert with sides positioned adjacent the side surfaces of the mounting slot and cutting edges extending from the rotational axis is mounted in the slot. The insert includes rake surfaces adjacent the cutting edges that are positioned above the mounting slot. At least one coolant channel is disposed with at least one coolant outlet directed at the sides of the insert at a position below the rake surfaces. The coolant outlet is configured to disperse coolant in a curtain across the entire rake face of each cutting edge.
Patent CA-3180369-A1 (CA)
Title: Compositions comprenant un anticorps dirige contre le recepteur de l'interleukine 6 pour le traitement de la polyarthrite rhumatoide et procedes d'utilisation associes
Inventor: ALBRECHT INKA
IPC: C07K16/28
Filed: 2021-05-25
Abstract: La présente invention concerne des compositions et des méthodes de traitement et d'atténuation des symptômes de la polyarthrite rhumatoïde à l'aide d'un anticorps ou d'un fragment de liaison à l'antigène de celui-ci qui se lie de manière spécifique au récepteur humain de l'interleukine 6 (hIL-6R).
Patent CA-3181699-A1 (CA)
Inventor: LASKAR WILLIAM JOSEPH
IPC: A01H5/10
Filed: 2022-11-10
Abstract: A wheat variety designated 6PQAJ29B, the plants and seeds of wheat variety 6PQAJ29B, methods for producing a wheat plant produced by crossing the variety 6PQAJ29B with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety 6PQAJ29B with another wheat line or plant, and the creation of variants by backcrossing, mutagenesis or transformation of variety 6PQAJ29B are disclosed. Methods for producing other wheat varieties or breeding lines derived from wheat variety 6PQAJ29B and to wheat varieties or breeding lines produced by those methods are also provided.
Patent CA-3181832-A1 (CA)
Title: Anti-reflective camera housing system
Inventor: KNOX SAMUEL
IPC: G03B17/56
Filed: 2021-07-01
Abstract: Embodiments of the present disclosure relate to an amusement park attraction installation (56) including a camera (68) disposed on a side of a window (64), where the camera (68) includes a lens (104) and is configured to capture image data indicative of movement of a guest (16) on an opposite side of the window (64). The amusement park attraction installation (56) also includes a light source (124) positioned on the side of the window (64) and a camera housing (14) disposed at least partially about the camera (68), where the camera housing (14) has an inner volume (102) and an opening (120) surrounded by an edge (126) of the camera housing (14), the lens (104) is disposed within the inner volume (102), and the edge (126) of the camera housing (14) is in abutment with a surface (180) of the window (64).