baber/WOPTO huggingface dataset:
Patent CA-2719442-A1 (CA)
Inventor: ZALCBERG JOHN R
IPC: A61P39/00
Filed: 2010-10-27
Abstract: The invention provides a method of treating and/or preventing a toxicity associated with epidermal growth factor receptor (EGFR) inhibitor therapy in a subject, the method comprising administering to the subject an effective amount of a steroid sulfatase (STS) inhibitor. The toxicity may be ocular toxicity; or dermatologic toxicity, such as papulopustular rash. The EGFR inhibitor may be selected from the group consisting of: a small molecule; an antibody or derivative or fragment thereof; another agent that targets the extracellular or intracellular domain of the EGFR, such as a tyrosine kinase inhibitor selected from the group consisting of: erlotinib; gefitinib; lapatinib; and any combination thereof. The EGFR inhibitor may also be antibody selected from the group consisting of:  cetuximab; panitumumab; and any combination thereof.   Preferably the STS inhibitor is selected from the group consisting of.  alternative STS  substrates; reversible STS inhibitors; and irreversible STS inhibitors; and any combination thereof. A preferred STS inhibitor is the irreversible nonsteroidal STS  inhibitor STX64.   In some embodiments, the subject receiving EGFRI therapy has a cancer comprising cells that express wildtype k-ras and/or wildtype b-raf. In other embodiments, the cancer may be hormone-dependent. Cancers that may be treated with EGFRI therapy include colorectal cancer and non-small cell lung cancer.
Patent CA-2721353-A1 (CA)
Title: Swallowing air pulse therapy mouthpiece and method for the use thereof
Inventor: BARAN GEORGE
IPC: A61J7/00
Filed: 2009-04-15
Abstract: An oral appliance for administering a stimulus, such as a substance, to the mouth of a user includes a flexible tube having an inlet portion, a first curved portion forming an ear loop connected to the inlet portion, a second curved portion forming a lip bend connected to the first curved portion, and an outlet portion extending from the second curved portion. Alternatively, a mouthpiece for delivering a substance to the mouth of a user includes a housing having an inlet portion, a riser portion extending upwardly from the inlet portion and a curved outlet portion. A flexible tube is coupled to the housing. A method of delivering a substance to a predetermined location in a user's mouth includes disposing a flexible tube between a row of teeth and an interior surface of a cheek. The flexible tube has an exit port positioned in a rear portion of the user's mouth. No portion of the flexible tube is disposed between the upper and lower teeth of the user such that the upper and lower teeth can be closed against each oth-er. The method further includes dispensing a substance through the exit port.
Patent CA-2722068-A1 (CA)
Inventor: LOVTSUS ANDREY ALGERDOVICH
IPC: C01B33/035
Filed: 2009-04-20
Abstract: The invention relates to a polycrystalline silicon production method. The inventive method involves supplying a gas mixture based on a silicon-containing gas to a reduction reactor via a tube system and precipitating silicon on heated surfaces in such a way that an effluent gas mixture is formed. The silicon precipitation process is simultaneously carried out in at least two reactors which are connected in series by the tube system for transporting the gas mixture. Then, the gas mixture used for the operation of all the reactors is supplied at entry into the first reactor and is continuously transmitted through all the connected in series reactors.
Patent CA-2723079-A1 (CA)
Inventor: PENG LING
IPC: C07H19/056
Filed: 2009-04-29
Abstract: The present invention relates to novel compounds of formula (A): in the form of a free base or of an addition salt with an acid. The invention also relates to process of preparation of compounds of formula (A), to composition comprising them and to their application in therapeutics and in particular in cancers.
Patent CA-2723968-A1 (CA)
Inventor: PLATENBURG GERARDUS JOHANNES
IPC: A61K31/7088
Filed: 2009-05-14
Abstract: The invention relates to a nucleic acid molecule that binds and/or is complementary to the nucleotide molecule having sequence 5'-GUGGCUAACAGAAGCU (SEQ ID NO 1) and to its use in a method for inducing skipping of exon 44 of the DMD gene in a DMD patient.
Patent CA-2724213-A1 (CA)
Inventor: GOLDING BERNARD
IPC: C07D495/14
Filed: 2009-05-13
Abstract: This invention relates to the discovery of 3-and 5-substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula (I) shown below wherein the meanings of the substituents are defined in claim 1 and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
Patent CA-2724548-A1 (CA)
Inventor: GROSS WIBKE
IPC: A61K8/22
Filed: 2009-02-17
Abstract: The invention relates to an agent for bleaching keratinic fibers, characterized in that in a cosmetic carrier it comprises hydrogen peroxide and at least one cationic 3,4-dihydroisoquinoline derivate of the following general structure (I), where the group R1 is a C1-C6-alkyl group, a C2-C6-alkenyl group, a C2-C6-hydroxyalkyl group, a C1-C6-alkoxy-C2-C6-alkylg group, a carboxy-C1-C6-alkyl group, an aryl-C1-C6-alkyl group, a C1-C6-dialkylamino-C2-C6-alkyl group, a heteroaryl-C1-C6-alkyl group, a 3-oxobutyl group, a 2-oxopropyl group, an aryl group, or a heteroaryl group, the groups R2, R3 and R4 independently of each other can be a hydrogen atom, a hydroxy group, an amino group, a di(C1-C6)alkylamino group, a C1-C6-alkoxy group, halogen, a nitro group, a carboxy group, a nitrile group, an optionally substituted aryl group, a C2-C6-alkenyl group, an optionally substituted heteroaryl group, or R2 and R3 together can form a further carbocyclic or heterocyclic ring that is condensated on and can be saturated or unsaturated and can optionally be substituted by up to three substitutes, the anion X- is a physiologically tolerable anion and - at least one alkanol amine of the following general structure (II), where n is a natural number from 2 to 6. The invention further relates to the use of said agent for bleaching hair and to a corresponding method.   (see formula I) (see formula II).
Patent CA-2725148-A1 (CA)
Inventor: PARK HO BYUNG
IPC: F21V19/00
Filed: 2009-05-22
Abstract: The present invention relates to an LED lighting apparatus installed in a place whereof the surface needs a uniform illumination or luminance distribution, the LED lighting apparatus comprising an LED-lighting unit module having plural LED light sources arranged on the inner or outer curved surface of a half cylinder, wherein at least two LED-lighting unit modules are arranged in the longitudinal direction of the half cylinder.
Patent CA-2731481-A1 (CA)
Title: Structure de support multicouche
Inventor: BRILL RYAN S
IPC: A47C7/02
Filed: 2009-07-21
Abstract: La présente invention a pour objet une structure de support multicouche fournissant un support dassise ergonomique et adaptable. La structure de support multicouche comprend des couches coopératives multiples pour maximiser le confort et le support globaux tout en augmentant ladaptation à des variations localisées de charge, par exemple de la charge appliquée lorsquune personne sassoit sur une chaise. Les couches coopératives comprennent chacune des éléments tels que des pixels, des ressorts, des rails de support, et dautres éléments pour procurer ce confort et ce support adaptables. La structure de support multicouche utilise également un matériau aligné pour procurer une structure de support souple mais durable. En conséquence, la structure de support multicouche procure un confort maximal pour une large gamme de formes et de tailles de corps.
Patent CA-2732455-A1 (CA)
Inventor: LANSINGER JERE R
IPC: B60S1/48
Filed: 2009-08-18
Abstract: A windshield washer fluid heater having a housing which defines a housing chamber. A subhousing is disposed in the housing chamber. This subhousing is constructed of a thermally conductive material and divides the housing chamber into an outer housing chamber between the housing and the subhousing, and an inner housing chamber inside the subchamber. The outer housing chamber and inner housing chambers are fluidly isolated from each other. A core is disposed in the inner housing cham-ber thus forming an annular fluid chamber between the core and the subhousing.  A washer fluid inlet on the housing is open to one end of the annular chamber while a washer fluid outlet at the other end is open to the other end of the annular chamber. An engine coolant inlet is open to the outer chamber while an engine coolant outlet is also open to the outer chamber at a position spaced from the inlet so that fluid flow into the coolant inlet flows through the outer housing chamber and to the coolant outlet.  Alternatively, an electric heater is used to heat the housing chamber containing the annular fluid chamber.
Patent CA-2733155-A1 (CA)
Title: Hockey stick
Inventor: IE CITRA A
IPC: A63B59/14
Filed: 2009-08-06
Abstract: A composite hockey stick having a turbular hollow shaft and a blade is disclosed. The shaft includes a region of focused weight in the form of an overlay coating that is applied on top of the internal surfaces of the cured shaft using a coating plug. The blade includes a focused weight region that is inserted into a cavity within the cured composite blade. Methods and suitable materials for constructions of the various components of the blade and shaft are also disclosed.
Patent CA-2735169-A1 (CA)
Title: Induction de l'expression de p53 par neutralisation de la neuropiline-2 pour le traitement des cancers
Inventor: BORG CHRISTOPHE
IPC: C07K16/28
Filed: 2009-08-26
Abstract: La présente invention est relative à l'utilisation d'anticorps anti-neuropiline 2 humaine, ou des ligands de la neuropiline 2 humaine dérivés de ces anticorps, pour l'obtention d'un médicament destiné à augmenter l'expression de p53 et à induire l'apoptose des cellules tumorales dans le cadre d'un traitement anticancéreux.
Patent CA-2736767-A1 (CA)
Inventor: KONRADI ANDREI W
IPC: A61K31/438
Filed: 2009-09-04
Abstract: The current invention provides compounds having a structure according to Formulae (1), (2), (3), and (4): wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae (1), (2), (3), and (4), as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae (1), (2), (3), and (4).
Patent CA-2737933-A1 (CA)
Inventor: IMTHURN PAUL D
IPC: H04N7/50
Filed: 2011-04-26
Abstract: An entropy encoder block for use in a context adaptive encoder with an entropy encoder block for encoding phrase words into code words using N search trees.  The N search trees each corresponding to a probability from a set of N probabilities used by a context modeling component of the context adaptive encoder. The context modeling component processing each phrase word to determine an associated probability corresponding to one of the N probabilities for each phrase word. The entropy encoder block comprising a plurality of encoding elements for receiving, from the context modeling component, phrase words and an indication of the associated probability for each phrase word, each encoding element of the plurality of encoding elements including an encoder having an encoding engine; and one or more lookup tables each containing search tree data representative of one of the N search trees such that all N search trees are represented by at least one encoding element, but not all N search trees are represented in every encoding element, the encoding engine operative to receive input phrase words and encode each input phrase word using a lookup table corresponding to the indication of the associated probability of the input phrase word.
Patent CA-2741175-A1 (CA)
Inventor: DAGHER HABIB J
IPC: B32B21/08
Filed: 2009-10-20
Abstract: The present invention resides in one aspect in a building material that comprises wood and a composite polymeric material that is combined with the wood in a heterogenous admixture. The composite polymeric material incorporates fibers in a polymeric matrix. The fibers can be chopped, continuous, or combinations thereof. In addition, the fibers can be unidirectionally oriented and/or randomly oriented. Suitable fibers for use in the composite polymeric material are glass, polymers, carbon, combinations thereof, and the like. However, the present invention is not limited in this regard as other fibers known to those skilled in the pertinent art to which the invention pertains can be used without departing from the broader aspects of the present invention.  Suitable polymeric material for the polymeric matrix include thermoplastic polymers, thermosetting polymers, or a combination of thermosetting and thermoplastic polymers.
Patent CA-2741244-A1 (CA)
Inventor: HOWINGTON LARRY C
IPC: A47F3/04
Filed: 2011-05-27
Abstract: A tank-less refrigerated display device having an open floor is configured to sit directly upon a floor in a facility such as a supermarket or other food product retail facility. The tank-less and floorless display device includes a front wall section that is substantially free of fans or other electrical components. The front wall section may be readily removable to permit convenient roll-in and roll-out of food product display devices. A cooling coil is mounted in a lower portion of a rear wall. A single set of fans are configured to push air to be chilled through the cooling coil and into a chilled air distribution system. The chilled air distribution system includes a rear wall flue having a vertical profile that is at least partially tapered, and a horizontal top wall flue having a frontal outlet configured to discharge chilled air over an open front in the form of an air curtain.
Patent CA-2741561-A1 (CA)
Title: Methods and systems for virtual energy management display
Inventor: VOGEL WILLIAM STEVEN
IPC: G05D3/12
Filed: 2008-11-21
Abstract: A method and system of virtual energy management display involves periodically receiving via a mesh local area network electronic data representing energy management-related information by a RF  communication-enabled memory storage device coupled to an electronic display device within a home area network. Electronic data representing telemetry information is likewise periodically received by the RF  communication-enabled memory storage device from at least one RF communication-enabled energy management-related device within the home area network.    The electronic data is converted to a common format by an application running at least in part on the memory storage device and displayed on a screen associated with the display device.
Patent CA-2743713-A1 (CA)
Inventor: SCHOEDEL NICOLE
IPC: C01B32/50
Filed: 2009-11-26
Abstract: A process for removing impurities, in particular oxides of sulphur (SO x) and/or oxides of nitrogen (NO x) from oxygen-containing gas streams by scrubbing with at least one washing agent is described. In order to achieve effective gas purification in an economical manner even in the case of so-called large "oxyfuel"  furnaces which operate with oxygen as fuel gas, it is proposed to convert the impurities at an elevated pressure of at least 2 bar with at least one basic constituent of the washing agent into salts and to wash out said impurities as dissolved salts.
Patent CA-2744490-A1 (CA)
Inventor: KOHLER KARL A
IPC: B31B50/00
Filed: 2011-06-23
Abstract: A carton for containing a plurality of articles. The carton comprises a bottom panel, a first side panel foldably, and a second side panel. At least one end flap comprises a first portion foldably connected to the one of the first side panel and the second side panel, a second portion foldably connected to the first portion, and a third portion foldably connected to the second portion. The carton has at least one reinforced corner that comprises a reinforced end panel and a reinforced portion of one of the first side panel and the second side panel. The reinforced end panel comprises the second portion and the third portion of the at least one end flap. The reinforced portion comprises the third portion of the at least one end flap and a portion of the one of the first side panel and the second side panel.
Patent CA-2745195-A1 (CA)
Inventor: FUSHIWAKI YUSUKE
IPC: C22C38/00
Filed: 2009-11-25
Abstract: A galvanized steel sheet includes a zinc plating layer which is disposed on a steel sheet containing 0.01% to 0.15%  C, 0.001% to 2.0% Si, 0.1% to 3.0% Mn, 0.001% to 1.0% Al, 0.005% to 0.060% P, and 0.01% or less S on a mass basis, the remainder being Fe and unavoidable impurities, and which has a mass per unit area 20 g/m2 to 120 g/m2. An oxide of at least one selected from the group consisting of Fe, Si, Mn, Al, and P is present in a surface portion of the steel sheet that lies directly under the zinc plating layer and that extends up to 100 µm from the surface of a base steel sheet.  The amount of the oxide per unit area is 0.05 g/m2 or less in total. The steel sheet has excellent corrosion resistance, anti-powdering property during heavy machining, and strength.
Patent CA-2745425-A1 (CA)
Inventor: PRENTICE KRISTA M
IPC: C10G65/04
Filed: 2009-12-30
Abstract: An integrated process for producing lubricant base oils from feedstocks under sour conditions is provided. The ability to process feedstocks under higher sulfur conditions allows for reduced cost processing and increases the flexibility in selecting a suitable feedstock. The sour feed can be delivered to a catalytic dewaxing step without any separation of sulfur and nitrogen contaminants, or a high pressure separation can be used to partially eliminate contaminants.
Patent CA-2746550-A1 (CA)
Inventor: DOMKE IMME
IPC: B03C1/015
Filed: 2009-12-09
Abstract: The present invention relates to a method for separating at least one first substance from a mixture containing said at least one first substance in an amount of 0.001 to 1.0 wt %, based on the total mixture, and at least one second substance, comprising at least the following steps: (A) bringing the mixture into contact, (B) optionally adding at least one dispersant, (C) treating the dispersion with at least one hydrophobic magnetic particle, (D) separating the enrichment product from step (C) from the mixture by applying a magnetic field, (E) optionally splitting the separated enrichment product from step (D).
Patent CA-2748675-A1 (CA)
Inventor: TAYLOR THOMAS P
IPC: E21D20/00
Filed: 2009-01-21
Abstract: A connection apparatus for securing a facing to a soil reinforcing element wherein the soil reinforcing element has a pair of adjacent longitudinal wires with horizontally extended converging portions, a stud having a first end attached to the horizontally extended converging portions, and a second end bent upwards and terminating at a head, a facing anchor having a pair of vertically disposed loops adjacently extending from the facing and having an opening for receiving a vertical portion of the stud, and a device configured to secure the vertical portion of the stud against separation from the opening between the vertically disposed loops, wherein the stud and the attached soil reinforcing element are capable of swiveling in the horizontal and vertical directions.
Patent CA-2749738-A1 (CA)
Inventor: MURRAY DONALD LOUIS
IPC: B30B15/16
Filed: 2011-08-22
Abstract: A method and a press for preparing a pressed article from compressible and cohesive biomass particles are provided. The method comprises providing a first pressing ram and a second pressing ram operating in opposite directions and disposed in a compression chamber, in retracted position; supplying a quantity of biomass particles in a space in the compression chamber between the first and second pressing rams; dosing the compression chamber; extending the first pressing ram towards the biomass particles in the compression chamber; displacing the biomass particles with the first pressing ram towards the second pressing ram; detecting abutment of the biomass particles on the second pressing ram once the biomass particles are displaced by the first pressing ram to touch the second pressing ram; applying pressure to the biomass particles with the first pressing ram by extending the first pressing ram to abut the biomass particles on the second pressing ram and with the second pressing ram by extending the second press ram to abut the biomass particles on the first pressing ram; detecting a pressure applied to match a predetermined compression pressure and continuing to extend the first pressing ram and the second pressing ram until a predetermined time at the matched compression pressure has elapsed, thereby forming a pressed article; stopping the extension of the second pressing ram when a predetermined extension length for the second pressing ram is reached; continuing to extend the first pressing ram until a predetermined additional time has elapsed after the stopping; ejecting a pressed article made of compressed biomass particles from the compression chamber.
Patent CA-2750218-A1 (CA)
Title: Electric deterrent device having knitted conductors
Inventor: DONOHO BRUCE
IPC: H05C3/00
Filed: 2010-01-19
Abstract: Electric pest deterrents device having knitted conductors are presented. An elongated conductor comprising at least a single conducting strand knitted with itself or with other conducting strands can be attached to a based of the device. The conducting strands can be knitted according to one or more patterns to form textured surfaces having raise protrusions.
Patent CA-2753780-A1 (CA)
Inventor: LEE REO
IPC: H04W12/08
Filed: 2011-09-28
Abstract: A method and system is provided for using an access list stored on a memory of a first computing device, the access list for controlling communication between the first computing device and a plurality of computing devices in a Bluetooth communication network.
Patent CA-2757759-A1 (CA)
Title: Immune stimulating composition comprising an extract of aronia sp. in combination with selenium and/or zinc
Inventor: ESCHMANN KLAUS
IPC: A61K33/30
Filed: 2010-05-06
Abstract: The present invention pertains to a composition which comprises a combination of Aronia extract in an amount of at least about 10 µg/mg and seleniumin in an amount from about 0,0001 µg/mg to about 2.0 µg/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.
Patent CA-2759351-A1 (CA)
Title: Low-profile threshold barrier
Inventor: DUNN STEVEN BRYAN
IPC: E06B11/02
Filed: 2011-11-24
Abstract: A low-profile barrier and method of installation is provided including a barrier door located in an opening defined by a frame having a pair of upwardly extending arms connected to a lower cross member. In an un-installed position, the lower cross member has a curvature biasing the upwardly extending arms outward. In an installed position, the curvature of the lower cross member is compressed to zero so that the lower cross member lays flat against a lower surface.
Patent CA-2765538-A1 (CA)
Inventor: KIM JEONG YUN
IPC: H04N5/262
Filed: 2010-06-15
Abstract: A method for creating content and a portable terminal adapted therefor are disclosed. An image is selected. The camera captures an image of at least one object from within an image currently being received by the camera. New content is created by combining the captured image of the at least one object with the selected image.