baber/WOPTO huggingface dataset:
Patent SG-11201806512V-A (SG)
Title: Copanlisib biomarkers
Inventor: PENA CAROL
IPC: C12Q1/68
Filed: 2017-01-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 10 August 2017 (10.08.2017) WIPO I PCT (10) International Publication Number WO 2017/134030 Al 111111111111110111011111111111010111110 011101111110111110111110111111111110111111 (51) International Patent Classification: C12Q 1/68 (2006.01) A61K 31/519 (2006.01) (21) International Application Number: PCT/EP2017/051988 (22) International Filing Date: 31 January 2017 (31.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/289,715 1 February 2016 (01.02.2016) US (71) Applicant: BAYER PHARMA AKTIENGESELL- SCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). (72) Inventors: PENA, Carol; 341 Mount Airy Rd., Basking Ridge, NJ 07920 (US). LIU, Li; 11 Hillside Drive, East Hanover, NJ 07936 (US). CHENG, Jie; 18 Dixon Ln, Belle Mead, NJ 08502 (US). KOCHERT, Karl; Kirschallee 1174, 14469 Potsdam (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Monheim am Rhein (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 17 / 13 4030 Al (54) Title: COPANLISIB BIOMARKERS (57) : This invention provides biomarkers based on the gene expression profiling which can discriminate between patients who response to and/or with longer progression free survival and patients who do not response to and/or with shorter progression free survival from copanlisib treatment in lymphoma including indolent and aggressive NHLs and CLLs. The present invention relates to the use of genes from the BCR, PI3K, NFkB, IL6, inflammation and stromal processes as predictive biomarkers for various human cancers including but not limited to NHLs.
Patent IS-2449-B (IS)
Inventor: CARROLL STEVEN S
IPC: C07H19/167
Filed: 2003-06-25
Abstract: The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
Patent AT-388528-B (AT)
Title: Gripper
Inventor: BLUEMEL EDUARD ING
IPC: B25J15/10
Filed: 1987-03-25
Granted: 1989-07-25
Abstract: The invention relates to a gripper in which three fingers can be centrally adjusted with regard to a gripping centre and one of the fingers can be disengaged for switching over from a three-finger operation to a two-finger operation. According to the invention, provision is made for the fingers 15, 16, 17 to be mounted on a gripper which essentially has a Y-shape, for one of the three fingers 15, 16, 17 to be mounted so as to be movable on each of the legs 8, 9, 10, for it to be possible for the centre finger 17 situated between the outer fingers 15, 16 to be stopped independently of the outer fingers 15, 16, and for each outer finger 15, 16, in addition to a gripping surface 26 inclined at an angle with respect to the gripping surface 26 of the other respective outer finger and intended for central gripping, to have a further gripping surface 25, these further gripping surfaces 25 on the two outer fingers 15, 16 running parallel to one another. <IMAGE>
Patent DK-162848-B (DK)
Inventor: VANGAEVER MARC
IPC: E01C19/15
Filed: 1987-01-12
Abstract: 1. Sweeping method comprising the combined use of a mechanical brush (9) and a container (10) at the front of a motor vehicle, in which the front edge (26) of the forwardly open container (10) is arranged almost against the ground to be swept, the ground is swept by driving the brush in rotation so that the swept material is projected rearwardly through the container opening and the material in the container is removed by raising the container (10) and inclining its opening downwardly and in which the brush is moved freely and automatically away from the container so as to clear its opening when an obstacle is encountered and the brush is automatically returned to its initial position when the obstacle disappears, characterized in that, during sweeping, the brush (9) is freely and automatically lowered under the effect of gravity towards the ground adjacent to the opening of the container (10) and in that, in the removal position, when the opening of the container is inclined downwardly well above the ground, the brush is freely and automatically moved away under the effect of gravity from the front edge of the container so as to clear the container opening and the brush (9) is possibly used to help remove the granular material from the container.
Patent HU-204158-B (HU)
Inventor: HOLLOSI SZILARD
IPC: A01H5/10
Filed: 1991-01-16
Abstract: A találmány fehér virágú és barna magvú, korai érésű, jó szárszilárdságú, finom jellegű, felálló, a Barbara fajtánál alacsonyabb és jó kiegyenlítettségű, a Kz White és a H. 2 olajlenfajták keresztezéséből egyedszelekcióval nemesített olajlenfajta. Hengeres szárának vastagsága tág térállásban meghaladja a 2,0 mni-t, a szár színe éréskor sárga, tű lérésben sötétbarna. Levele lándzsás, ritkás és sötétzöld. Virága csillag alakú, sziromlevele fehér és sodrott, prozószál és bibeszál fehér, portok sárga. Toktermése lapított gömbölyű, csúcsos és zárt. Magja közepes, alakja elliptikus, mindkét oldalán dombon! és ezennagtömege 8,09,0 g. Tenyészideje 100-110 nap. Jellegzetessége, hogy szára dúsan elágazó és alacsony, virágja fehér és csillag alakú, sodrott, tokjának rekeszfala szőrözött, magja világosbarna színű, a mag élénkbama színezettsége közepes, olajtartalma 4042%. Septoria linicolával szemben ellenálló, továbbá a vetéstől számított 52-55. napon virágzik, (1. ábra)  HU 204 158 A A leírás terjedelme: 4 oldal (ezen bellii 1 lap ábra)
Patent HU-191119-B (HU)
Title: Diagnostic method to the nuclear reactors for checking hermetic seal of the cases of heating elements by measuring fission inert gases with mass spectrometer
Inventor: BALOGH KADOSA
IPC: G21C17/06
Filed: 1984-01-23
Abstract: During operation of a nuclear reactor noble gases e.g. krypton, xenon are created among other fission products. Production of fission products is proportional to fuel burn-up, the quantities and the proportions of the various isotopes being known. - The gaseous fission products may escape from imperfectly sealed fuel cans into the primary coolant circuit. Quantities of gaseous fission products are determined by a mass-spectrometer. - Subsequently the ratio of gaseous fission products within the fuel cans and in the primary cooling circuit is established. This ratio indicates the extent of leaks in the fuel cans. - The mass-spectrometer measurements are taken using samples taken from the primary coolant water, or from the gas space of the primary coolant degasser unit, after separating the noble gas fission products from active gases.
Patent HU-185032-B (HU)
Title: Process for producing n-acylamides of alpha-ceto-carboxylic acids
Inventor: BONSE GERHARD
IPC: C07C235/88
Filed: 1981-03-06
Abstract: alpha -Ketocarboxylic acid N-acylamides of the formula R1-CO-CO-NH-CO-R2 in which R1 is an optionally substituted aliphatic radical with up to 12 carbon atoms, an optionally substituted cycloalkyl radical with 3 to 10 carbon atoms, an optionally substituted heterocyclic radical, and R2 is an optionally substituted aliphatic radical with up to 8 carbon atoms or an optionally substituted phenyl radical, are prepared by reacting an acyl cyanide of the formula R1-CO-CN with a carboxylic acid anhydride of the formula R2-CO-O-CO-R2 in the presence of a strong acid, and then adding water to the reaction mixture. The products can be used directly in the synthesis of known herbicides.
Patent HU-191204-B (HU)
Inventor: SZUHAR MIHALY
IPC: H01L29/74
Filed: 1983-03-22
Abstract: A találmány szerinti eljárás és elrendezés alkalmazásúval meghajtó áramot nem igénylő ki/bekapcsolásra alkalmas félvezető analóg kapcsolót kapunk, mely több egymással logikai ÉS-kapcsolatban álló, vezérlő elektróda alkalmazása esetén több dimenziós kapcsoló mátrix kialakítására is alkalmas. (5. ábra)  -1-
Patent MX-167162-B (MX)
Title: Procedimiento de elaboracion y curado de un producto carnico
Inventor: MAIRAL D FERNANDO ABELLA
IPC: A23B4/033
Filed: 1985-11-07
Abstract: La presente invención se refiere a procedimiento de elaboración y conservación de un producto cárnico, que siendo aplicable preferentemente en la curación de piezas de jamón fresco, deshuesado o no y comprendiendo una serie de fases en si conocidas y consistentes en: preparación: sazonar las piezas de jamón fresco y deshuesado mediante la mezcla tradicional de los aditivos; cloruro sódico, azúcar, nitrato potásico, nitrato sódico, ácido ascórbico o sus sales. Introducir dichas piezas, previa adaptación de las mismas para que adquieran una configuración definitiva, en una cámara de refrigeración para la igualación de la mezcla de salazón. Curado: introducir tales piezas en una cámara de secado sometida a una temperatura comprendida entre -1 y +5 grados C., y a una presión de máximo vacío, durante un período de tiempo comprendido entre 48 y 72 horas, en el cual la citada mezcla de salazón penetra en la masa muscular, con la particularidad de que el citado dispositivo rotativo gira continuamente a un máximo de 10 revoluciones/minuto, consistiendo además el procedimiento en añadir a la mezcla de salazón una cepas bacterianas con alta actividad lipofílica seleccionadas entre los géneros Micrococcus sp, Pseudomonas sp, Vibrio sp, Estafilococos coagulasa-negativos y otras bacterias que desarrollen tal actividad, sin producir productos secundarios no aptos para el consumo humano.
Patent NO-136513-B (NO)
Inventor: SCHUMM ERICH
IPC: A47K5/12
Filed: 1972-02-22
Abstract: Såpeutleverer.
Patent YU-43409-B (YU)
Title: Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate
Inventor: LJ ANTONCIC
IPC: C07D211/90
Filed: 1985-05-21
Abstract: A new, technologically easily feasible process for the preparation of 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, comprising a partrial hydrolysis of dimethyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate in an inert organic solvent at a temperature between room temperature and the reflux temperature of the reaction mixture with an aqueous solution of alkali hydroxide and the reaction of the obtained 3-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-5 -carboxylic acid either with N-(2-hydroxyethyl)-N-benzyl-methylamine in the presence or absence of an organic solvent in the presence of N,N'-dicyclohexylcarbodiimide at a temperature of between 25 DEG  and 120 DEG  C. or with N-(2-haloethyl)-N-benzyl-methylamine in the presence of an inert organic solvent and of a proton acceptor at a temperature of between 25 DEG  and 140 DEG  C., to yield the title compound, which can be, if desired, converted to its hydrochloride salt. The hydrochloride salt is known under the generic name "nicardipine hydrochloride" and is used as a valuable therapeutic in the therapy of cerebral insufficiency.
Patent AT-409355-B (AT)
IPC: B23K11/24
Filed: 1996-11-08
Granted: 2002-07-25
Abstract: A process is disclosed for generating a sinusoidal, periodically variable welding current with a high power density for a multipoint resistance welding machine powered by a monophase alternating current. The welding current is generated from a three-phase mains voltage source by means of a pulse width modulated current inverter circuit and the frequency of the welding current is set at a higher level than the frequency of the mains voltage source.
Patent AT-392239-B (AT)
Title: Rotating or rotating and folding door for rail vehicles
Inventor: HAUER KURT ING
IPC: B61D23/00
Filed: 1985-10-17
Granted: 1991-02-25
Abstract: In order to avoid accidents as a result of getting on to vehicles and in order to provide a seal against relative wind and airborne snow, the step boxes of vehicles are sealed off at ground level by slides or flaps when the door is closed. In the case of swivel step flaps, which are articulated to the door lever and are coupled to the movement of the door, the force of gravity is not sufficient for the flap to press satisfactorily under its weight against the bottom of the wagon in order to provide a seal and avoid giving rise to clattering noises. This is achieved by means of a hook, attached to the swivel door flap 2, and which possibly has a roller or cam wheel 10 which, on closing, engages under a wedge- shaped slope or rail 8, arranged on the lower part of the step box 6, and thus presses against the swivel door flap 2.
Patent DK-165274-B (DK)
Inventor: MEUNIER JEAN-PAUL
IPC: A01G31/00
Filed: 1986-04-10
Abstract: Substrata for soil-free cultivation are characterized by a relatively low by-volume mass. They are also constituted of fine fibers. The substrata present the advantage of a high degree of water retention, even for small thicknesses.
Patent FI-76388-B (FI)
Title: Process for increasing the lifespan of and/or reducing the risk of breakage in the loaded suction roller of a paper machine
Inventor: KORHONEN JUSSI
IPC: D21F/
Filed: 1983-01-24
Granted: 1988-06-30
Abstract: Process for increasing the lifespan of and/or reducing the risk of breakage in the loaded suction roller, e.g. a press suction roller (10) for a paper machine, in which the suction roller (10) is loaded by a nip in such a manner that the stress on the suction roller (10) is changed at least once during each revolution of the suction roller (10). Suction roller corrosion fatigue is improved by setting the suction roller (10) inner surface and suction hole (12) radial openings at least in their inner mouths (12') into lower - that is to say negative - potential in relation to the electrolyte fluid (E) in the inner surface of suction roller (10') and holes (12). An anode electrode or electrodes are arranged in contact with the electrolyte fluid. In between electrodes and the suction roller, a voltage difference for cathode-based corrosion resistance is arranged. Anode electrode or electrodes and current feed to the suction roller is fitted in the axial direction of the suction roller so that sufficient and effective and well spread current density is achieved. As the stressed suction roller surface (10) is stainless steel, the electrical potential (U1) between its inside (10') and anode electrode falls in the area of 0... -700mV (saturated calomel-electrode).<IMAGE>
Patent FI-71546-B (FI)
Inventor: NITSCHKE JOHN STEPHEN
IPC: C03B23/023
Filed: 1983-08-19
Granted: 1986-10-10
Abstract: An improved apparatus including a localized heater that moves along the direction of conveyance with conveyed glass sheets to provide localized heating of a portion of each glass sheet to be bent without heating the rest of the glass sheet prior to its subsequent treatment. This invention is especially suitable for locally heating designated portions of glass sheets as they are heated while being conveyed through a furnace on a horizontal roller conveyor where the designated portion of glass sheets are to be formed with bends having relatively short radii of curvature at a bending station. The apparatus includes a pair of elongated localized gas heaters, each of which is positioned above the portion of the glass sheet which requires significant bending. These heaters are mounted on a carriage driven by a drive mechanism. The drive mechanism causes the carriage to move along a path parallel to the path of glass sheet conveyance to allow the heaters to continuously heat the designated portions of the glass sheet between an upstream position and a downstream position of the carriage. After the carriage reaches its downstream position, the drive mechanism causes the carriage to return to its upstream position in preparation for another cycle.
Patent FI-86884-B (FI)
Inventor: BARRATT CHRISTIAN
IPC: C11D3/386
Filed: 1987-11-20
Granted: 1992-07-15
Abstract: Detergent compositions comprising detergent cellulases are disclosed. The compositions are formulated to provide a near-neutral or mildly-alkaline wash liquor pH. The compositions comprise a clay soil removal polymer and, optionally, a fabric-softening clay.
Patent FI-93943-B (FI)
Title: Calcium sulphate alpha-mono:hydrate mfr. by autoclaving di:hydrate - mouldings obtd. from powder have controlled porosity, fully converted crystals are controlled from acicular to squat columnar
Inventor: KOSLOWSKI THOMAS
IPC: C04B11/00
Filed: 1990-01-10
Granted: 1995-03-15
Abstract: Mouldings of fine gypsum dihydrate contg. 15-60 vol.% porosity and over 5 vol.% air in pores are heated with water in autoclave at 110-180 deg.C under controlled pressure to recrystallise to alpha-hemihydrate. Mouldings are pref. placed in autoclave at room temp. so that water condensed on surface isdrawn into pores by capillary action; also part of water pref. arises from dihydrate -at least 50 vol.% of porosity pref. contains air. Mouldings are pref. formed at 14N/mm2 in presence of 3-20 wt.% physically bonded water. Growth controlling additives are pref. mixed with dihydrate and are pref. fine brown coal, peat, wood, humic acid, timber prods. or mixt. thereof. Portion of dihydrate pref. is obtd. from gas desulphurisation plant in power station fired on brown coal.
Patent FI-88349-B (FI)
Title: Signal processing system for wide screen television with even picture resolution for centre and side bands
Inventor: ISNARDI MICHAEL ANTONY
IPC: H04N7/015
Filed: 1990-08-27
Granted: 1993-01-15
Abstract: An NTSC compatible EDTV wide screen system encodes and decodes a television signal N containing (1) an NTSC main signal with standard format, which in addition has low frequency picture information compressed in its upper sweep region; (2) high frequency side panel picture information X; and (3) high frequency horizontal auxiliary luminance information Z. In the encoder, a within-field-average 64, 76 is created from the components 2 and 3 before modulation of an alternating subcarrier 80. The component 1 is averaged 38 within the field with the exclusion of the compressed side panel information before it is combined 40 with the modulated alternating subcarrier. <IMAGE>
Patent FI-97221-B (FI)
Inventor: COMMANDEUR RAYMOND
IPC: C07C7/148
Filed: 1990-12-27
Granted: 1996-07-31
Abstract: Process for the synthesis of oligomers of benzyltoluene in which the condensation of benzyl chloride with toluene is carried out in the presence of ferric chloride and then a treatment with, in particular, sodium methoxide is carried out to eliminate the chlorinated organic products. The oligomers obtained, essentially benzyltoluene and dibenzyltoluene, are suitable as a dielectric fluid.
Patent FI-96818-B (FI)
Inventor: JOHANSSON BERTHOLD
IPC: A01G23/08
Filed: 1991-11-11
Granted: 1996-05-31
Abstract: PCT No. PCT/SE90/00195 Sec. 371 Date Nov. 5, 1991 Sec. 102(e) Date Nov. 5, 1991 PCT Filed Mar. 27, 1990 PCT Pub. No. WO90/13998 PCT Pub. Date Nov. 29, 1990.The invention relates to a method and a device for cutting off the trunk of a tree by detonation of an explosive charge in contact with the trunk. The invention solves the problem of providing a safe and convenient way of cutting off the trunk of a tree which has fallen to an inclined position where it rests against another tree or against an electric overhead line. To the trunk there is, at the desired level above ground, attached a holder which carries an explosive charge and can from the ground be mounted on the trunk, whereupon the charge is detonated and the trunk section above the cut-off level severed from the section below. In this way the top section is either directly released from its support or can conveniently be so released.
Patent FI-102902-B (FI)
Inventor: KIRSCH GERALD
IPC: C07J53/00
Filed: 1992-02-26
Granted: 1999-03-15
Abstract: New 14alpha, 17alpha-bridged oestratrienes of formula (I) are claimed. When OR3 is in the alpha-configuration: R1, R2, R3 = H, -CO-R4 or -(CH2)n-CO2H, where n = 1-4. R1 may also be benzyl, 1-8C alkyl or 3-5C cycloalkyl; R4 = an organic gp. with up to 11C atoms. When OR3 is in the beta-configuration: R1, R2, R3 = H or 1-12C acyl; R1 may also be 1-8C alkyl. In both cases, A-B is an etheno or etheno bridging bond. 18 cpds. are specifically claimed, including 3-benzyloxy-14alpha, 17alpha-ethano- 1, 3, 5(10)oestratriene-16alpha, 17beta-diol and 14alpha, 17alpha-ethano -1, 3, 5(10) oestratriene-3, 16alpha, 17beta-triol. Also claimed is a method of preparing (I), e.g. from 3, 16beta, 17beta-triacetoxy-14alpha, 17alpha-ethano-1, 3, 5 (10)-oestratriene-16alpha-carbonitrile. For treating disorders involving oestrogen deficiency, unit oral dose is 0.001-0.05 mg. Solns. for intramuscular injection contain 0.01-1 mg (I) per ml, and vaginal salves contain 0.1-10 mg (I) per 100 ml. For contraception, tablets contain 0.003-0.05 mg (I) and 0.05-0.5 mg of a gestagen.
Patent FI-109131-B (FI)
Inventor: FASTREZ JACQUES
IPC: C12N11/06
Filed: 1994-05-26
Granted: 2002-05-31
Abstract: A method for selecting recombinant micro-organisms of which the surface comprises at least one molecule having enzymatic activity, wherein the recombinant micro-organisms are immobilized on a solid support by a covalent inhibitor of the active site of said molecule, which is connected to the solid support by an arm; the recombinant micro-organisms are recovered and all or part of their genome is isolated and cloned.
Patent FI-108990-B (FI)
Inventor: MEYER THOMAS A
IPC: B05B11/00
Filed: 1995-06-16
Granted: 2002-05-15
Abstract: PCT No. PCT/US93/11906 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Dec. 14, 1993 PCT Pub. No. WO94/13258 PCT Pub. Date Jun. 23, 1994Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.