baber/WOPTO huggingface dataset:
Patent EA-020131-B1 (EA)
Title: Scorpion peptides that block human t-lymphocyte potassium channels and method of use thereof
Inventor: POSSANI POSTAY LOURIVAL DOMINGOS
IPC: A61K38/04
Filed: 2007-05-14
Abstract: Potassium channels hKv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high affinity and specificity potassium channels hKv1.3, their pharmaceutical compositions, and methods for their use to block Kv1.3 potassium channels, to treat various immunological conditions and to diagnostic applications. Methods for their chemical synthesis and correct folding are also disclosed. Exemplary peptides correspond to protein components (Vm23 and Vm24) isolated from the venom of the Mexican scorpion Vaejovis mexicanus smithi. Vm23 and Vm24 bind to hKv1.3 channels in an almost irreversible manner, showing a Kd value in the order of 3 picomolar range, when applied to human lymphocytes cultures in vitro. Proposed are methods and techniques used for their chemical and functional characteristics as well as the results of in vivo experiments on the DTH-response of sensitized rats. Neither Vm24 nor synthetic Vm24 are toxic to mice when injected at relatively high concentrations (assayed are up to 200 mcg/20 g mouse, i.e. 10,000 micrograms per kilogram mouse body weight). These peptides (Vm24 and Vm23) and their functional equivalent analogs with at least 83% of sequence identity are lead compounds, candidates for the treatment of various immunological conditions and diagnostic applications.
Patent EA-017964-B1 (EA)
Title: Method for producing antibodies or hybrid proteins in avian ebx tm cells and use of produced antibodies and proteins
Inventor: MEHTALI MAJID
IPC: A61K38/00
Filed: 2008-05-21
Abstract: The invention generally relates to the field of recombinant protein production. More particularly, the invention relates to the use of avian embryonic derived stem cell lines, named EBx TM®, for the production of proteins and more specifically glycoproteins such as antibodies. The invention is useful for the production of monoclonal IgG1 antibody subtype having high cell-mediated cytotoxic activity. The invention relates to the use of such antibodies as a drug to treat cancers and inflammatory diseases.
Patent EA-016821-B1 (EA)
Title: Crystalline form of [3-(4,5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl)phenyl]-(5-hydroxy-1-methyl-1h-pyrazol-4-yl)methanone
Inventor: GEBHARDT JOACHIM
IPC: A01N43/80
Filed: 2008-07-04
Abstract: The present invention relates to crystalline forms of [3-(4,5-dihydro-3-isoxazolyl)- 2-methyl-4-(methylsulfonyl)phenyl]-(5-hydroxy-1-methyl-1H-pyrazol-4-yl)methanone, which is also known by the common name topramezone. The invention also relates to a method for the production of these crystalline forms, and to formulations which contain one of these crystalline forms of topramezone for protecting plants.
Patent EA-017381-B1 (EA)
Title: Method for detecting dose of chemical agents for plant protection safe for human and animals
Inventor: LITVINKO NATALYA MIKHAILOVNA
IPC: C12Q1/44
Filed: 2009-12-03
Abstract: The invention relates to clinical biochemistry, biotechnology and medicine. A method is disclosed for detecting pesticide doses permissible for human and animals based on the change of Apancreatic phospholipase activity (test) and without change (reference) relative to phosphatidylcholine as artificial lipid membranes (liposomes) by detecting the content of hydrolysis products by thin-layer chromatography. The rate of substrate hydrolysis which characterizes the change of an enzyme activity caused by pesticide is determined for test and reference samples by the content of phosphorus in phospholipids and their lyso derivatives. Pesticide dose as safety is determined provided the change of enzyme activity in its presence not exceeding 20% of the reference value. Having a small amount of an available raw material (10-100 mkg of pesticide), without using laboratory animals the claimed method allows to measure the Aphospholipase activity by the value of relative hydrolysis rate of liposomes as model of cell membrane compared to the reference value as an indicator of cell wall disintegration during digestion in the presence of the tested pesticide and without it.
Patent EA-023378-B1 (EA)
Title: Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (gbm) and other cancers
Inventor: SCHOOR OLIVER
IPC: A61P35/00
Filed: 2009-09-28
Abstract: The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.
Patent EA-024410-B1 (EA)
Title: Distribution manifold
Inventor: MELNIKOV PAVEL EDUARDOVICH
IPC: F16L41/03
Filed: 2012-10-23
Abstract: The invention relates to civil engineering. The technical result consists in broadening the range of means for distribution of water between different heating and water appliances that are provided with headworks allowing water supply under the disk of each headwork with any configurations of connected liquid supply and drain pipelines, which makes it possible to provide a stable value of distributed liquid pressure setpoint due to elimination the possibility of pulsation of the headwork elements. The distribution manifold comprises a prolate body 1 with a longitudinal cavity 2, whereon there are arranged in series at least two assemblies for lateral pipeline connection, each assembly including a radial nipple 3 with a cavity 4 interconnecting, through a hole 5 in the body 1, with the longitudinal cavity 2, a connectable nipple 6 and a seating nipple 7 arranged on the radial nipple 3 on opposite sides and on one axis, a threaded plug 8, and a headwork having a closure member 9 with a disk 10, the closure member being reciprocal and fixable in a seat bushing 11 with a thread 12. A main seating surface 16 for the headwork disk 10 is provided on the body 1, inside the cavity 4 of the radial nipple 3, around the hole 5 to the longitudinal cavity 2 of the body 1. An additional seating surface 19 for the headwork disk 10 is provided on the inner surface of the radial nipple 3, around a hole 17 to a cavity 18 of the connectable nipple 6. The radial nipple 3 and the seating nipple 7 have, on the side of their free ends, threaded sections 20, 21, on which the headwork is fixed with the seat bushing 11 on one of them, and the threaded plug 8 is fixed on the other.
Patent EA-026481-B1 (EA)
Title: Desalinization system and desalinization method
Inventor: SEKINE Yasunori
IPC: C02F3/12
Filed: 2012-08-16
Abstract: This desalinization system, which obtains industrial-use water and drinking water from seawater and wastewater, is provided with a purification device that purifies wastewater by removing activated sludge therefrom; a first RO membrane that removes salt from the output of the purification device by transferring said salt to first concentrated water, thereby producing industrial-use water; a UF membrane that seawater passes through and that removes particulates from said seawater; a second RO membrane that removes salt from the treated output of the UF membrane by transferring said salt to second concentrated water, producing drinking water; an agitation device to which the second concentrated water from the second RO membrane and the first concentrated water from the first RO membrane are sent to be agitated; and a third RO membrane removing salt from the liquid mixture agitated by the agitation device by transferring said salt to third concentrated water, producing industrial-use water.
Patent EA-028025-B1 (EA)
Title: Odour filter for a range hood, in particular for treating fumes and odours in household environments, and related range hood
Inventor: SANTUCCI MAURO
IPC: F24C15/20
Filed: 2013-04-09
Abstract: The present invention relates to a filter (105) for a hood (101), comprising at least two filtering layers (401, 402) arranged consecutively along the direction of flow; the filter (105) has a substantially cylindrical shape, thus defining a lateral filtering surface (503), wherein said filtering layers (401, 402) are arranged concentrically on the lateral surface (503), being placed one inside the other. The present invention further relates to a filter- housing assembly, which comprises a housing (106) for receiving the filter (105), wherein the housing (106) comprises at least one bottom aperture (301) providing a fluidic connection between a hood (101) and the filter (105), and further comprises at least one aperture for the outflow of filtered air from said filter (105). Finally, the present invention relates to a hood, such as an extraction hood or a recirculating hood.
Patent EA-033400-B1 (EA)
Title: Anti-cd3 antibody and use thereof
Inventor: SMITH ERIC
IPC: C07K16/28
Filed: 2013-09-19
Abstract: The present invention relates to an isolated human antibody or antigen-binding fragment thereof that binds CD3; to a pharmaceutical composition for the treatment of a disease or condition which is improved, ameliorated, inhibited or prevented by stimulation of CD3 activity or signaling, or stimulation of T cell activation, comprising such antibody or antigen-binding fragment thereof and a pharmaceutically acceptable carrier or diluent; and to the use of said pharmaceutical composition for preparing a medicament for the treatment of a tumor in a subject.
Patent EA-030961-B1 (EA)
Title: Use of glutarimide derivatives for treating eosinophilic diseases
Inventor: NEBOLSIN VLADIMIR EVGENIEVICH
IPC: C07D211/88
Filed: 2014-11-12
Abstract: The present invention relates to the use of biologically active glutarimide derivatives of general formula (I) or pharmaceutically acceptable salts thereof as therapeutic agents for the treatment of eosinophilic diseases, preferably of allergic nature, in particular bronchial asthma, allergic rhinitis, polypous rhinosinusopathies, eosinophilic colitis, eosinophilic syndrome, allergic conjunctivitis, atopic dermatitis, Churg-Strauss syndrome, anaphylactic shock, Quincke's edema, eosinophilic vasculitis, eosinophylic esophagitis, eosinophilic gastroenteritis, fibroses, to pharmaceutical compositions comprising glutarimide derivatives of general formula (I), wherein the meanings of the substituents R, R'and Rare defined in the claims.
Patent EA-033230-B1 (EA)
Title: Method and plant for biological wastewater treatment
Inventor: SEKOULOV IVAN
IPC: C02F3/30
Filed: 2015-04-30
Abstract: What is disclosed is a method for biological wastewater treatment comprising a degradation of the organic load, called BOD degradation, and comprising a denitrification and downstream nitrification for conversion of nitrogen compounds present in the wastewater to nitrogen gas using microorganisms called heterotrophs for the BOD degradation, microorganisms called denitrificants for the denitrification, and microorganisms called nitrificants for the nitrification. The method of the invention features contacting of the wastewater with the three groups of microorganisms mentioned in a defined separation. This is done by growing the heterotrophs, the denitrificants and the nitrificants each on different, separate carrier bodies and dividing them correspondingly into three successive reactors or dividing them into two successive reactors, the second reactor containing the nitrificants and the heterotrophs for BOD degradation in stratified form by height. By means of this method, compared to conventional systems, it is possible to achieve both reductions in volume and in the space required for the reactors, and a reduction in the energy demand for the oxygen supply.
Patent EA-033916-B1 (EA)
Title: Bag making method
Inventor: MITIN ALEXANDER VLADIMIROVICH
IPC: B65D30/10
Filed: 2017-01-23
Abstract: The invention relates to methods for manufacturing bags of spunbond with a rectangular bottom, using ultrasonic bonding. The technical problem is in non-uniform load distribution from the bag bottom along the seams resulting in seam tear on the bag bottom. The technical result of the suggested method consists in increased strength of produced bag due to location of seams on its sides with simplification of the method. The above technical result is achieved by the fact that the method of making a bag includes feeding the material from a roll, creasing the folding lines, cutting the material transversely to the direction of feeding from a roll for workpieces, folding a workpiece and fastening of the workpiece parts using seams formed by ultrasonic bonding; according to the claimed solution, a sheet of spunbond is selected as the material, after feeding the material from the roll, the edges of material located in parallel to the direction of material feed from the roll are roll inward to the backside, handles are manufactured along both rolled-in edges before creasing the lines, whereas folding of the workpiece includes the following: the material of workpiece along the edges located perpendicularly to the rolled-in edges, is to be rolled in at a right angle to the backside to form the sides of bag, the material of workpiece along the rolled-in edges is rolled inward at a right angle to the backside for formation the face walls of the bag, the parts of each side adjoining to the face walls of the bag are located on the outer side relatively to the part of side which remained in the initial position, the seams are formed on the sides of bag.
Patent EA-034278-B1 (EA)
Title: Condensed heterocyclic compounds and pesticides
Inventor: KUDO TAKAO
IPC: A01P7/02
Filed: 2016-02-12
Abstract: The invention is intended to provide novel pesticides, especially insecticides or acaricides. A condensed heterocyclic compound represented by the formula (1) or its salt or an N-oxide thereof:wherein D substituted with -S(O)Ris a ring represented by any one of D1, D2 and D3; Q is a ring represented by any one of Q1, Q2, Q3 and Q4; Ris C-Calkyl, C-Chaloalkyl, (C-C)alkyl optionally substituted with R, C-Calkenyl, C-Chaloalkenyl, C-Calkynyl, C-Chaloalkynyl, C-Ccycloalkyl, C-Chalocycloalkyl, C-Ccycloalkyl(C-C)alkyl, C-Chalocycloalkyl(C-C)alkyl or hydroxy(C-C)alkyl; Ris C-Calkoxycarbonyl; and n is an integer of 0, 1 or 2.
Patent EA-037685-B1 (EA)
Title: Method for processing porous metal-based implants
Inventor: LOGINOV YURIY NIKOLAEVICH
IPC: B22F3/26
Filed: 2017-11-24
Abstract: The proposed invention relates to the field of additive technologies, used for the manufacture of implants, preferably from titanium alloys. A method for processing porous metal-based implants includes preparing a model of cellular structures, and manufacturing a cellular structure by using a source of energy to act upon a fusible material. The method is characterised in that following manufacture of the cellular structure, the structure is submerged in a liquid medium, cooled to a temperature below the phase transition temperature at which the medium transitions from a liquid state to a solid state, and subjected to plastic deformation, after which the structure is heated to the phase transition temperature at which the medium transitions from a solid state to a liquid state, and the liquid medium is removed. Water, or molten salts having a transition temperature from solid to liquid state not exceeding the recrystallisation temperature of the metal material, or a molten metal or a molten alloy, are used as the liquid medium. The technical result consists of enhancing the strength characteristics of an implant.
Patent EA-038884-B1 (EA)
Title: Method of submental intubation of trachea
Inventor: SOLOVIEV MIKHAIL MIKHAILOVICH
IPC: A61M16/04
Filed: 2018-12-27
Abstract: The invention relates to medicine, namely to maxillofacial surgery and anesthesiology, and is designed to be used in treatment of patients with panfacial fractures. A tunnel is formed by the 3 cm long skin incision in the submental area, laterally from the midline, 2 cm from the mandibular bone edge. After this, deep layers of tissues are separated by a noninvasive method with changing the direction of route three times: along muscular layers (m. platisma, m. mylohyoideus), in accordance with the direction of the Wharton's duct and lingual vessels and nerves in the submucosal layer. At each of the stages of the tunnel creation, thorough controlled hemostasis is performed, after which the intubation tube is removed and skin wound is closed. This method ensures reducing the surgical route associated injuries, including the hemostasis facilitation, mitigation of intraoperative and postoperative complications, improving the cosmetic result.
Patent EA-035538-B1 (EA)
Title: Method and arrangement for monitoring characteristics of a furnace process in a furnace space and process monitoring unit
Inventor: BJOERKLUND PETER
IPC: F27D21/02
Filed: 2016-09-14
Abstract: The invention relates to a method and to an arrangement for monitoring characteristics of a furnace process in a furnace space (2) limited by a furnace shell (3) of a metallurgical furnace (4). The arrangement comprises a process monitoring unit (6) having a frame (7) mounted by means of a mounting means (9) on the metallurgical furnace (4) outside the furnace space (2) of the furnace shell (3). The invention relates also to a process monitoring unit for use in the method and/or in the arrangement.
Patent EA-037422-B1 (EA)
Title: Method and apparatus for paste backfill
Inventor: REVELL MATHEW
IPC: B01F35/71
Filed: 2017-01-12
Abstract: The invention relates to a method and to an apparatus for paste backfill. The apparatus comprises a mixing means configured to produce paste (11), a storage means configured to store paste (11), and a feeding means configured to feed paste (11) to a borehole (1). The mixing means and the storing means is formed of a combined storage and mixing means (2). The feeding means comprises a bottom discharge port (9) configured to feed paste (11) from the combined storage and mixing means (2). The apparatus comprises monitoring means configured to monitor the level of paste (11) in the combined storage and mixing means (2) to maintain the level of paste (11) in the combined storage and mixing means (2) above a setpoint value so as to prevent air from entering the borehole (1) from the combined storage and mixing means (2).
Patent EA-035631-B1 (EA)
Title: Core-shell particle for use as a filler for feeder compositions
Inventor: LEHMANN SANDRA
IPC: B22C1/00
Filed: 2017-06-27
Abstract: The invention relates to core-shell particles for use as a filler for feeder compositions for producing feeders, comprising: (a) a core, which has one or more cavities and a wall enclosing said cavities, the core (a) having an average diameter within the range from 0.15 to 0.45 mm; (b) a shell enclosing the core and consisting of or comprising (b1) particles comprising or consisting of a material from the group consisting of calcined kaolin or cordierite, the particles (b1) having a d10 value of at least 0.05 m and a d90 value of at most 45 m; and (b2) a binder which binds the particles (b1) to each other and to the core (a).
Patent ES-2176083-B1 (ES)
Title: Procedimiento para la obtencion de oxido de cinc con aditivos para la fabricacion de ceramicas no ohmicas.
Inventor: FERNANDEZ LOZANO JOSE FRANCISC
IPC: C22B19/34
Filed: 2000-06-02
Granted: 2004-01-16
Abstract: Procedimiento para la obtención de óxido de cinc con aditivos para la fabricación de cerámicas no óhmicas. Describe un procedimiento que permite obtener polvo cerámico basado en óxido en cinc para la fabricación de materiales cerámicos no óhmicos. El control de los compuestos intermedios a través de los parámetros de la precipitación, permite obtener aglomerados esféricos de nanopartículas de ZnO y un tratamiento térmico posterior. Las partículas de ZnO obtenidas se suspenden en una disolución acuosa, y en ciertas condiciones de pH, se precipitan sobre ellas bismuto, antimonio, manganeso como aditivos principales. Posteriormente el polvo se somete a un tratamiento térmico y finalmente, mediante un proceso de turbinado a alta velocidad en medio acuoso, se incorporan otros aditivos como Co, Nb, Sn, Ni, Cr, Si, Al a partir de sus respectivos óxidos con tamaño de partícula submicrónico.
Patent ES-2183711-B1 (ES)
Title: Procedimiento para la obtencion de leche liquida de origen animal con un contenido reducido en lactosa.
Inventor: ZULAIKA OROZCO MIREN JAIONE
IPC: A23C9/12
Filed: 2001-05-10
Granted: 2004-05-16
Abstract: Procedimiento para la obtención de leche líquida de origen animal con un contenido reducido en lactosa. El procedimiento comprende la adición de enzima b-galactosidasa a una leche líquida de origen animal de partida previamente estandarizada, homogeneizada y pasterizada esterilizada o tratamiento UHT, en una cantidad adecuada para hidrolizar parte de la lactosa contenida inicialmente en la leche líquida de partida para alcanzar el contenido en lactosa deseado en la leche líquida con un contenido reducido en lactosa. La leche líquida resultante es apta para el consumo humano, particularmente por personas con intolerancia a la lactosa.
Patent ES-2221516-B1 (ES)
Title: Anclaje para planchas onduladas de cubierta por la parte inferior.
Inventor: FERNANDEZ ROMAN VICENTE RAUL
IPC: F16B29/00
Filed: 2002-03-22
Granted: 2005-12-16
Abstract: Anclaje para planchas onduladas de cubierta por la parte inferior. Consiste en un conjunto de dos piezas, un tornillo espárrago (1) con un mecanismo de bloqueo de giro (2) y un soporte inferior semicircular (3) que se acopla a éste mediante una tuerca (4). Evita la necesidad de situarse sobre la plancha ondulada de cubierta para su colocación, permitiendo que este proceso se realice completamente desde la parte inferior.
Patent ES-2231028-B1 (ES)
Title: Procedimiento de obtencion de fungicida agricola.
Inventor: MATA ONTALBA ANDRES
IPC: A01N65/40
Filed: 2003-10-28
Granted: 2006-10-01
Abstract: Procedimiento de obtención de un fungicida agrícola. El procedimiento consiste en mezclar agua destilada e hidróxido potásico en un recipiente y calentarlos a una temperatura comprendida entre 75 y 85° C. En otro recipiente se calienta ácido graso vegetal de coco hasta una temperatura de 75 a 85° C. Ambos productos se depositan en un tercer recipiente produciéndose el mezclado del agua destilada, hidróxido potásico y ácido graso vegetal de coco, calentándose en este tercer recipiente y batiéndose la mezcla hasta una temperatura de 85° C, produciéndose la fusión molecular y obteniéndose un compuesto que resulta ser un fungicida jabonoso que se utiliza como bactericida contra hongos y bacterias, con efectos desinfectantes y fertilizantes el hidróxido potásico interviene en un 7 al 10%, el agua destilada en un 60 a un 68% y el ácido graso de coco en un 25 a un 33%.