baber/WOPTO huggingface dataset:
Patent DK-0699665-T3 (DK)
Inventor: HOWBERT JAMES JEFFRY
IPC: A61P25/00
Filed: 1995-06-05
Granted: 2003-03-31
Abstract: A compound of the formula <CHEM>  wherein:  m is 0 or 1;  n is 0 or 1;  X is -(CHR<4>)p-(CHR<6>)q-, where,     p is 0 or 1;     q is 0 or 1; and R<4> and R<6> are independently selected from the group consisting of hydrogen and C1-C3 alkyl; R<2> is phenyl, 2- or 3-indolyl, 2- or 3-indolinyl, benzothienyl, benzofuranyl, or naphthyl; any one of which groups may be substituted with one or two moieties independently selected from the group consisting of halo, C1-C3 alkoxy, trifluoromethyl, C1-C4 alkyl, phenyl-C1-C3 alkoxy, and C1-C4 alkanoyl groups; R<1> is hydrogen, trityl, phenyl, diphenylmethyl, phenoxy, phenylthio, hexamethyleneiminyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, benzofuranyl, quinolinyl, isoquinolinyl, tetrahydropyridinyl, reduced quinolinyl, reduced isoquinolinyl, phenyl-(C1-C6 alkylidenyl)-, phenyl-(C1-C4 alkoxy)-, quinolinyl-(C1-C6 alkylidenyl)-, isoquinolinyl-(C1-C6 alkylidenyl)-, reduced quinolinyl-(C1-C6 alkylidenyl)-, reduced isoquinolinyl-(C1-C6 alkylidenyl)-, benzoyl-(C1-C6 alkylidenyl)-, C1-C4 alkyl, or -NH-CH2-R<5>; any one of which R<1> groups may be substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, amino, C1-C4 alkylamino, or di(C1-C4 alkyl)amino; or any one of which R<1> groups may be substituted with phenyl, piperazinyl, C3-C8 cycloalkyl, benzyl, C1-C4 alkyl, piperidinyl, pyridinyl, pyrimidinyl, C2-C6 alkanoylamino, pyrrolidinyl, C2-C6 alkanoyl, or C1-C4 alkoxycarbonyl; any one of which groups may be substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, amino, C1-C4 alkylamino, di(C1-C4 alkyl)amino, or C2-C4 alkanoylamino; or R<1> is amino, a leaving group, hydrogen, C1-C4 alkylamino, or di(C1-C4 alkyl)amino;  R<5> is pyridyl, anilino-(C1-C6 alkylidenyl)-, or anilinocarbonyl;  R<8> is hydrogen or C1-C6 alkyl; and R<3> is phenyl, phenyl-(C1-C6 alkylidenyl)-, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C1-C8 alkyl, naphthyl, C2-C8 alkenyl, or hydrogen; any one of which groups except hydrogen may be substituted with one or two halo, C1-C3 alkoxy, C1-C3 alkylthio, nitro, trifluoromethyl, or C1-C3 alkyl groups;  or a salt or solvate thereof. This invention provides a novel series substituted 2-imidazolines which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.
Patent DK-0734384-T3 (DK)
Inventor: ANDERSEN KIM
IPC: A61P43/00
Filed: 1994-12-15
Granted: 2001-01-02
Abstract: 3-substituted 1-arylindole compound having general Formula I <CHEM>       wherein Ar is an optionally substituted aryl group; X represents a bond, a divalent hydrocarbon group or methyleneoxy or -thioxo; R<1>_R<4> are hydrogen or substituents; R<5> is hydrogen, hydroxy, alkoxy, halogen, trifluoromethyl, alkyl or alkenyl; R<6> and R<7> are hydrogen, alkyl or alkenyl;   R<8> is alkyl or alkenyl a group of Formula 1a or 1b : <CHEM>   wherein; W is O or S; U is N or CH ; Z is (CH2)m, 1,2-phenylene, CH=CH, COCH2 or CSCH2-; V is O, S, CH2, or NR<10>, wherein R<10> is hydrogen or alkyl; U<1> is O, S, CH2 or NR<11>, wherein R<11> is as R<10>; and V<1> is NR<12>R<13>, OR<14>, SR<15> or CR<16>R<17>R<18>, where each of R<12>-R<18> are as the R<10>-substituents; R<9> is hydrogen or alkyl; or R<9> is linked to R<7> to form a ring; or R<8> and R<9> together form a morpholinyl or piperidinyl ring, the latter optionally substituted by alkyl or a group of Formula 1a or 1b, or a carbamoyl group, show central antiserotonergic activity and possibly also antidopaminergic activity and are, accordingly, useful in the treatment of central nervous system (CNS) disorders. The compounds are prepared by methodt known pr. se.
Patent DK-0759904-T3 (DK)
Inventor: NAKAMURA MITSUO
IPC: C07D211/22
Filed: 1995-04-10
Granted: 2000-10-02
Abstract: A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1 -piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1 -piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.
Patent DK-0784546-T3 (DK)
Inventor: ROESSLE MANFRED
IPC: G10L15/00
Filed: 1995-10-04
Granted: 1999-11-22
Abstract: PCT No. PCT/EP95/03905 Sec. 371 Date Apr. 4, 1997 Sec. 102(e) Date Apr. 4, 1997 PCT Filed Oct. 4, 1995 PCT Pub. No. WO96/11122 PCT Pub. Date Apr. 18, 1996An apparatus and method for limiting a vehicle speed based on voice inputs includes a sound recorder that receives a voice input. A first signal generator receives a vehicle speed sensor value, and outputs a vehicle speed signal. A signal memory receives the signals provided by the sound recorder and the first signal generator, and stores them as a pair of values upon receiving a store signal from a memory key. A first comparator compares the stored voice signal with a current voice signal output by the sound recorder, compares them, and outputs a coincidence signal based on the comparison. A second comparator compares the stored speed signal and a current speed signal received provided by the first signal generator, compares them, and outputs a difference signal. Based on the coincidence signal and the difference signal, the vehicle's speed is regulated so as not to exceed the stored speed signal.
Patent DK-0790859-T3 (DK)
Inventor: ALBERT GERT
IPC: C07C39/44
Filed: 1995-11-04
Granted: 1998-10-07
Abstract: PCT No. PCT/DE95/01552 Sec. 371 Date Mar. 10, 1997 Sec. 102(e) Date Mar. 10, 1997 PCT Filed Nov. 4, 1995 PCT Pub. No. WO96/14150 PCT Pub. Date May 17, 1996The invention is directed to an apparatus for contacting in a reactor solids in the form of free-flowing lumps with liquids or for contacting solids with liquids and gases by bringing the reactants into contact with each other, said reactor comprising a housing containing a screen in the area of which contacting takes place wherein the screen is a rotary screen drum 5, the screen drum 5 rotates in a bottom vat during the operation, said vat holding a gaseous or liquid medium reacting with the solids, and the bottom vat 10 can be lowered such that the solids in the screen drum 5 and the medium in the bottom vat 10 can be separated from each other whenever it is desired to alter or interrupt the chemical reaction or physical process.
Patent DK-0797987-T3 (DK)
Inventor: HIROAKI
IPC: A61K9/16
Filed: 1995-12-18
Granted: 2004-02-16
Abstract: This invention relates to sustained-release granular preparations obtained by wet-granulating an aqueous suspension, which comprises a medicinal ingredient, a fine particulate polymer having an average particle size not greater than 50  mu m and a plasticizer, into granules and treating said granules at a temperature not less than the lower one of a minimum film-forming temperature and glass transition temperature of a mixture of said polymer and said plasticizer. This invention is also concerned with a process for the production of the sustained-release granular preparations. According to the present invention, granular preparations having an excellent sustained-release property and a high safety to the human body can be easily produced in a simple manner.
Patent DK-0876471-T3 (DK)
Inventor: CHILDS STEPHEN LEE
IPC: C11D1/66
Filed: 1996-10-11
Granted: 2000-11-20
Abstract: Dryer-activated fabric softening compositions and articles having improved stability, for use in an automatic clothes dryer consisting essentially of: (A) from about 30% to about 75% of a diester quaternary ammonium (DEQA) compound having the formula:wherein R is a long chain, saturated and/or unsaturated, C8-C30 hydrocarbyl, or substituted hydrocarbyl substituent and mixtures thereof, and the counterion, X-, can be any softener-compatible anion; and, (B) nonionic softener at a level of from about 15% to about 50%, where the nonionic softener is fatty acid partial ester of sorbitan; and wherein the ratio of component (A) to component (B) is from about 3:1 to about 1:1.
Patent DK-0808815-T3 (DK)
Inventor: HUEBNER FRANK DR
IPC: B01J31/02
Filed: 1997-04-05
Granted: 2001-11-26
Abstract: Preparation of 2,3,5-trimethylhydroquinone (I) comprises a) reaction of keto-isophorone with an acylating agent in the presence of catalytic amounts of a protic acid and b) acid hydrolysis of the resulting trimethylhydroquinone ester. The protic acid is oleum, trifluoromethanesulphonic, chlorosulphonic, polyphosphoric acid or a mixture of these.
Patent DK-0906425-T3 (DK)
Inventor: PAESEN GUIDO CHRISTIAN
IPC: C12N5/10
Filed: 1997-05-19
Granted: 2005-07-11
Abstract: A vasoactive amine binding protein (VABP) that binds to vasoactive amines with a dissociation constant of less than 10-7 M, has a sequence homology to the VABP clones male specific histamine binding protein 1 (MS-HBP1), female specific histamine binding protein 1 (FS-HBP1), female specific histamine binding protein 2 (FS-HBP2), and Dermacenter reticularis 6 (D.RET6), such that 40% or more of the amino acids of the VABP clones that are completely conserved as identical residues when said VABP clones are in alignment with each other, are still completely conserved when said VABP is included in said alignment; and that contains a sequence motif selected from the group consisting of the motif D/E A W K/R; the motif Y/C E/D L/I W; and the motifs D/E A W K/R and Y/C E/D L/I W.
Patent DK-0915658-T3 (DK)
Inventor: BRAGULLA SIEGFRIED
IPC: A01N59/12
Filed: 1997-07-21
Granted: 2003-02-24
Abstract: PCT No. PCT/EP97/03922 Sec. 371 Date Jan. 29, 1999 Sec. 102(e) Date Jan. 29, 1999 PCT Filed Jul. 21, 1997 PCT Pub. No. WO98/04136 PCT Pub. Date Feb. 5, 1998A composition and process for protection against infection wherein the composition contains a) 10 to 100 g/l of polyvinyl alcohol polymers or copolymers having molecular weights from 18,000 to 200,000 as the film forming component, b) 0.2 to 3 g/l of iodine in the form of polyvinyl pyrrolidone iodine and/or 5 to 50 g/l of chlorhexidine as the disinfecting agent, and c) 2 to 50 g/l of ether carboxylic acids corresponding to formula R-(OC2H4)n-OCH2-COOH, where R is an alkyl group containing 4 to 10 carbon atoms and n is a number of 2 to 8.
Patent DK-0960071-T3 (DK)
Inventor: PEDERSEN JAN ERIK
IPC: B01D17/02
Filed: 1997-12-10
Granted: 2004-01-26
Abstract: A method for filtering hydrocarbon contaminated water for separation and recovery of the contaminants and recirculation of the water, wherein the water contaminated by hydrocarbons is, in a series of successive stages, caused to flow down through a cushion of a filtering hydrocarbon that floats on a defined surface of a water body and is permitted to flow via an underflow into the free portion of the water body prior to transfer via an overflow to the next stage, and where, in a final stage, approximately anhydrous hydrocarbon is drawn off as overflow while hydrocarbon-free water is removed as underflow, is carried out with the aid of an apparatus which, in operable state, comprises a series of successive basins filled with water (2, 3, 4) separated by walls (22, 23), where an upper part of each basin is bounded by means of fixed partition walls (32, 33) projecting downward in the water and is filled with a filtering hydrocarbon (12, 13, 14), where the final cushion of filtering hydrocarbon (14) downstream is bordered by a vertically displaceable outlet bin (47) for the contamination enriched hydrocarbon, and further comprising a water outlet (5, 6, 7, 8) comprising two successive horizontal watercourses (5, 6), having a declining ceiling (10, 11) in the direction of flow, and thereafter a vertical S-pipe (7, 17) having an outlet (8).
Patent DK-0946121-T3 (DK)
Inventor: HELMINGER KARL
IPC: A47L15/44
Filed: 1997-12-10
Granted: 2000-12-18
Abstract: The invention relates to a commercial dishwashing machine, where the detergent added to the first wash tank of the wash section is controlled by a regulator which controls a dosing device. The regulator is a fuzzy regulator, which in a learning phase determines characteristic influencing values of the system to be regulated. In the learning phase, detergent is continuously added to the first wash tank for a predefined period. The change in the water's conductivity over that period is determined. In the subsequent operating phase, the extent to which the conductivity measured deviates from a set value is determined. Dosing takes place by fuzzy regulation on the set value deviation, on the basis of the measured influencing values as fuzzy variables. Because in the learning phase all the influencing values of the dishwashing machine, dosage device and detergent are taken into account, dosing is automatically optimally adjusted to prevailing conditions.
Patent DK-0971714-T3 (DK)
Inventor: NEEDLEMAN PHILIP
IPC: A61K31/415
Filed: 1998-03-30
Granted: 2002-11-04
Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating dementia. In particular, the invention describes the method of preventing and treating dementia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of formula (I) wherein R<2>, R<3>, and R<4> are as described in the specification.
Patent DK-1023080-T3 (DK)
Inventor: STERN DAVID
IPC: C07K16/00
Filed: 1998-10-09
Granted: 2010-11-15
Abstract: The present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation end product (RAGE). The present invention also provides for an isolated peptide having an amino acid sequence A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-K-P-P-Q-R-L-E-W-K (Seq. ID No. 1). The present invention provides for a pharmaceutical composition comprising a therapeutically effect amount of an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of RAGE. The present invention also provides for a method for inhibiting interaction of an amyloid-² peptide with a receptor for advanced glycation end product which is on the surface of a cell, which comprises contacting the cell with the peptide or a functionally equivalent agent, wherein the peptide or agent is capable of inhibiting interaction of the amyloid-² peptide with the receptor for advanced glycation end product, and the peptide or agent is present in an amount effective to inhibit interaction of the amyloid-² peptide with the receptor for advanced glycation end product.
Patent DK-0978284-T3 (DK)
Inventor: UENO RYUJI
IPC: A61K31/557
Filed: 1998-11-16
Granted: 2008-10-27
Abstract: The present invention provides an antagonist for endothelin which is considered having a relation to a hypertension, Buerger disease, asthma, eyegrounds diseases, and the like. Said endothelin antagonist contains 15-keto-prostaglandin E compounds, especially 13,14-dihydro-15-keto-16-mono or dihalo-prostaglandins.
Patent DK-0961541-T3 (DK)
Inventor: VAN DEN BERG KAREL
IPC: A01J7/00
Filed: 1998-12-04
Granted: 2003-03-10
Abstract: A cleaning apparatus and method for cleaning components of automated milking apparatus which includes milking machines which are automatically connected and disconnected to the animals being milked. A rinsing liquid supply line supplies water through a protecting device and a heat exchanger to a junction which has a line leading to a rinsing liquid reservoir which includes a heating element to provide heat cleaning if desired, a line connected to a metering device to introduce an additive such as an alkali or acid, a branch line for rinsing components of the automatic milking machine such as teat cups and a branch line leading through non-return devices to a rinsing liquid buffer reservoir which can be pressurized by air pressure and used for cleansing components such as the teat cups and sensor on a robot arm and the device for cleaning the udders and teats of the animals being milked. Computer-controlled valving is provided for each of the branch lines for cleaning milking components of the automatic milking system, the rinsing liquid supply before the juncture and in the line to the rinsing liquid reservoir, as well as the rinsing liquid discharge line leading to the rinsing liquid buffer reservoir.
Patent DK-1021416-T3 (DK)
Inventor: MERKLE HANS RUPERT
IPC: C07D/
Filed: 1998-06-22
Granted: 2004-09-27
Abstract: Pyrazole derivatives are prepared by reacting carbonyl compounds R1-C(O)-CH(R2)-CH2R3 with hydrazine, its hydrate or its salts in 30 to 100% by weight sulfuric acid in the presence of catalytic amounts of iodine or of an iodine compound.
Patent DK-0985566-T3 (DK)
Inventor: SPRAFKE DIPL-ING
IPC: B60R13/08
Filed: 1999-07-28
Granted: 2005-06-27
Abstract: The device comprises a roof plate (1), on the interior side of which, shield plates (2.1-2.3) are located. The shield plates are made of a heat-insulating material, and are arranged such that an air gap (3.1-3.3) remains between the upper-side of the shield plates and the underside of the roof plate. The upper side of the shield plates is provided with a layer (4.1-4.3), which reflects the infrared radiation outwards. The reflecting layers may be made from e.g. stuck-on foils. The air gap can be between 10 to 20 mm, preferably 12 mm.
Patent DK-0969472-T3 (DK)
Inventor: COOKSON CHRISTOPHER J
IPC: G11B19/04
Filed: 1994-10-13
Granted: 2002-10-28
Abstract: A system using an optical disk format for representing several synchronized signals, e.g. multiple versions of motion pictures and multiple soundtracks which is made up of an optical disk (23), signal processors (67, 71), buffer circuitry (53, 55, 57, 59) and audio (91) and video (94) output devices. All signals are represented digitally, and the bits are arranged in data blocks. Each data block may contain a variable number of bits for each signal, ranging from none to many (relative to the other signals). This allows each signal to be represented by a variable rate bit stream, without one signal necessarily constraining another as far as bit representation is concerned. Multiple buffers are provided to insure that there are a sufficient number of bits available for each signal as required for immediate needs. When any buffer is full, reading of the data blocks stops temporarily so that no bits are lost.
Patent DK-0952254-T3 (DK)
Inventor: THEURER JOSEF
IPC: E01B27/17
Filed: 1999-02-17
Granted: 2004-03-15
Abstract: The track (3) in the prior intended position is measured and a slow track position error is eliminated, with the final intended position being calculated. With the determination of the correction values as the difference between the final and prior intended positions, a corresponding alteration of the static load and/or the cross forces acting on the track enables the final intended position of the track to be achieved.
Patent DK-1058719-T3 (DK)
Inventor: CEMENSKA RICHARD A
IPC: C10L1/32
Filed: 1999-02-05
Granted: 2005-03-14
Abstract: A fuel emulsion blending system and method for operating the same is provided. The disclosed embodiments of the fuel emulsion blending system includes a plurality of fluid circuits, including a hydrocarbon circuit, a fuel emulsion additive circuit, a water circuit and an optional alcohol/methanol circuit. Each of the inlet circuits are adapted for receiving the identified ingredient from a suitable source which optionally may be included as part of the blending system. The disclosed blending system further includes a first blending station adapted to mix the hydrocarbon fuel and fuel emulsion additives and a second blending station adapted to mix the hydrocarbon fuel and additive mixture received from the first blending station together with the water received from the source of water. The disclosed blending system further includes an emulsification station downstream of the blending stations which is adapted to emulsify the mixture of hydrocarbon fuel, additives and water to yield a stable fuel emulsion.
Patent DK-1107803-T3 (DK)
Inventor: ATKIN EDWARD
IPC: A61M1/06
Filed: 1999-08-23
Granted: 2004-03-08
Abstract: A flexible resilient breast pump insert adapted to fit onto a vacuum generating breast pump operable to cyclically generate and release a negative pressure is disclosed. The insert has deformable zones (11, 14) spaced from each other along the longitudinal axis of the insert which are connected to the source of negative pressure so that the zones (11, 14) are deformed sequentially when the negative pressure is applied, to cause them to move inwardly and outwardly relative to the users nipple and areola and apply a peristaltic pressure thereto.
Patent ES-2211380-T3 (ES)
Title: Dispositivo de proteccion contra impactos laterales mediante airbag.
Inventor: ACKER DOMINIQUE
IPC: B60R21/231
Filed: 1996-09-20
Granted: 2004-07-16
Abstract: Dispositivo de airbag de protección contra impactos laterales para el pasajero de un automóvil que tiene una fuente de gas a presión para el inflado del airbag de protección del tórax y el airbag de protección de la cabeza incorporado en el respaldo del asiento del pasajero. El dispositivo de protección contra impactos laterales se encuentra integrado en el respaldo (47) del asiento de pasajero y hace uso de una fuente de gas a presión (16) para el inflado de un airbag de protección del tórax (14) y un airbag de protección de la cabeza (12) que se abre hacia un lado del respaldo del asiento. El airbag de protección de la cabeza se despliega hacia arriba cuando se abre, siendo los 2 airbags independientes uno del otro o estando acoplados entre sí a través de unas aberturas de flujo (52).
Patent ES-2185532-T3 (ES)
Inventor: WEISSENMAYER STEFAN
IPC: B05D7/00
Filed: 2000-07-06
Granted: 2003-05-01
Abstract: Process for coating the surfaces of workpieces made of iron and steel comprises preparing a metallic almost pure surface; applying a base layer made of a mixture of a zinc powder and a thermally hardenable epoxy powder and thermally treating the workpiece to fix the base layer; applying an intermediate layer of a thermally hardenable epoxy powder and thermally treating the workpiece to fix the intermediate layer; and applying a covering layer of a powder made of a thermally hardenable coating material, especially based on polyester or polyurethane and thermally fixing the covering layer.
Patent ES-2237380-T3 (ES)
Title: Oxido de cinc como inhibidor del activador de plasminogeno de uso externo.
Inventor: YOSHIDA YUZO
IPC: A61P17/12
Filed: 2000-12-22
Granted: 2005-08-01
Abstract: El uso de óxido de cinc recubierto con 0, 1 a 70 por ciento en peso de sílice, en el que el mencionado óxido de cinc tiene un diámetro medio de partícula de menos de 0, 2 m, en la fabricación de una preparación externa para la piel áspera.