baber/WOPTO huggingface dataset:
Patent CY-1119854-T1 (CY)
Title: Ανθρωπινο μονοκλωνικο αντισωμα με ειδικοτητα για ε πρωτεϊνη ιου δαγκειου πυρετου οροτυπου 1 και χρησεις αυτου
Inventor: MACARY PAUL ANTHONY
IPC: C12P21/08
Filed: 2017-11-08
Abstract: Παρέχονται συνθέσεις και μέθοδοι για την θεραπευτική αγωγή ή πρόληψη μόλυνσης από ιό δάγκειου πυρετού σε ένα σπονδυλωτό υποκείμενο. Συγκεκριμένα, αποκαλύπτονται ανθρώπινα εξουδετεροποιητικά μονοκλωνικά αντισώματα κατά του ιού δάγκειου πυρετού που έχουν απομονωθεί από Β κύτταρα αθανατοποιημένα με ΕΜΒ προερχόμενα από ασθενείς που έχουν αναρρώσει από μόλυνση ιού δάγκειου πυρετού. Παρέχονται μέθοδοι για χορήγηση τέτοιων αντισωμάτων σε ένα σπονδυλωτό υποκείμενο σε μία ποσότητα αποτελεσματική για να μειώσει, εξαλείψει ή να προλάβει υποτροπή της μόλυνσης.
Patent CY-1119586-T1 (CY)
Title: Ταπενταδολη για προληψη και θεραπεια καταθλιψης και αγχους
Inventor: STEIGERWALD ILONA
IPC: A61P25/24
Filed: 2017-11-10
Abstract: Η εφεύρεση αφορά σε ταπενταδόλη (i) για χρησιμοποίηση στη θεραπεία πόνου σε ένα άτομο που πάσχει από κατάθλιψη και/ή από άγχος, και/ή (ii) για χρησιμοποίηση στη θεραπεία ή πρόληψη κατάθλιψης και/ή άγχους.
Patent CY-1124319-T1 (CY)
Title: Συνθεσεις λιποσωμικων ανοσοενισχυτικων
Inventor: DOMINOWSKI PAUL JOSEPH
IPC: A61K47/18
Filed: 2021-07-14
Abstract: Η παρούσα εφεύρεση παρέχει σύνθεση λιποσωμικού ανοσοενισχυτικού περιλαμβάνουσα εξωτερική μεμβράνη και εσωτερικό διαμέρισμα, με την εξωτερική μεμβράνη να περιλαμβάνει: ένωση τεταρτοταγούς αμμωνίου• στερόλη• φωσφολιπίδιο• και γλυκολιπίδιο. Επίσης παρέχονται συνθέσεις εμβολίων περιλαμβάνουσες το λιποσωμικό ανοσοενισχυτικό της παρούσας εφεύρεσης.
Patent CY-1125050-T1 (CY)
Title: Συστημα προστασιας απο τις υπερτασεις για συστηματα ασυρματης επικοινωνιας
Inventor: MILLER DOUGLAS WAYNE
IPC: H01T4/04
Filed: 2022-03-09
Abstract: Ένα σύστημα καταστολής υπερτάσεων παρέχει προστασία από υπερτάσεις τόσο τοπικά εντός του κτιρίου ραδιοφωνικών σταθμών, όπου βρίσκεται η μονάδα παραγωγής ισχύος και ο τηλεπικοινωνιακός εξοπλισμός όσο και εξ αποστάσεως από τα ραδιοφωνικά συστήματα και τις κεραίες που βρίσκονται έξω από το κτίριο στον πύργο επικοινωνίας. Μια εξωτερική μονάδα καταστολής υπερτάσεων παρέχει ένα αδιάβροχο περίβλημα τόσο για συσκευές καταστολής υπερτάσεων όσο και για συνδέσμους οπτικών ινών. Μια μονάδα καταστολής υπερτάσεων με δυνατότητα τοποθέτησης σε πλαίσιο παρέχει τοπική προστασία καταστολής υπερτάσεων εν σειρά για τον ηλεκτρικό εξοπλισμό που βρίσκεται στο σταθμό επικοινωνίας. Ένας μοναδικός δίσκος καταστολής υπερτάσεων μπορεί να αντικατασταθεί εν θερμώ, έτσι ώστε πολλαπλές συσκευές καταστολής υπερτάσεων να μπορούν να αντικατασταθούν ταυτόχρονα χωρίς να διακόπτεται η λειτουργία του ραδιοφωνικού συστήματος. Δομοστοιχεία καταστολής υπερτάσεων με δυνατότητα σύνδεσης μπορούν να χρησιμοποιηθούν τόσο στην εξωτερική μονάδα καταστολής υπερτάσεων όσο και στη μονάδα καταστολής υπερτάσεων που μπορεί να στηριχθεί σε πλαίσιο.
Patent GR-910300059-T1 (GR)
Title: Outdoors modular public telephone
Inventor: IBANEZ PALOMEQUE FRANCISCO
IPC: H04M17/02
Filed: 1991-11-15
Abstract: The essence of said telephone resides on a modular structure, on the basis of two superposed bodies, 1 and 2, respectively containing the telephone mechanisms and a coin collecting moneybox, the door 3 of the top body 1 being provided with a plurality of windows through which different modules are coupled and fixed, specifically the card insertion 12, the coin insertion 11, the data display 13, the keypad 14, the coin return 15 and the handset hanging 16 modules, some of which may optionally be eliminated and replaced by corresponding lids.
Patent HR-P20110092-T1 (HR)
Inventor: GRAMMENOS WASSILIOS
IPC: C07D401/14
Filed: 2011-02-04
Abstract: 3-(piridin-2-il)-[1,2,4]-triazinski spojevi opće formule Inaznačeni time što: R1, R2 označavaju nezavisno jedan od drugog OH, halogen, NO2, NH2, C1-C8-alkil, C1-C8-alkoksi, C1-C8-halogenalkil,C1-C8-halogenalkoksi, C1-C8-alkilamino ili di(C1-C8-alkil)amino, ili zajedno sa atomima ugljika za koje su vezani mogu obrazovati zasićeni 5-, 6- ili 7-karbociklus ili heterociklus, koji pored ugljičnih članova prstena ima i jedan ili dva heteroatoma izabrana iz grupe koja se sastoji od kisika i sumpora, pri čemu su karbociklus i heterociklus nesupstituirani ili imaju 1, 2, 3 ili 4 C1-C4-alkil grupe kao supstituente; R3 označava vodik, C1-C4-alkil, C1-C4-alkoksi, C1-C4-halogenalkil, C1-C4-halogenalkoksi, C3-C6-cikloalkil, C3-C6-cikloalkilmetil ili halogen; R4 označava vodik, C1-C4-alkil, C1-C4-alkoksi, C1-C4-halogenalkil, C1-C4-halogenalkoksi ili halogen; R5 označava C1-C8-alkil, C1-C8-halogenalkil, C1-C8-alkoksi, C1-C8-halogenalkoksi, C3-C8-cikloalkil, C3-C8-cikloalkiloksi, 5- ili 6-člani heteroaril, fenil, fenoksi, benzil, benziloksi, 5- ili 6-člani heteroarilmetil ili 5- ili 6-člani heteroariloksi, pri čemu su naprijed navedeni ciklični radikali nesupstituirani ili mogu imati 1, 2, 3, 4 ili 5 radikala Ra, pri čemu je Ra izabrano između OH, SH, halogena, NO2, NH2, CN, COOH, C1-C8-alkil, C1-C8-alkoksi, C1-C8-halogenalkila, C1-C8-halogenalkoksi, C1-C8-alkilamino, di(C1-C8-alkil)amino, C1-C8-alkiltio, C1-C8-halogenalkiltio, C1-C8-alkilsulfinila, C1-C8-halogenalkilsulfinila, C1-C8-alkilsulfonila, C1-C8-halogenalkilsulfonila, C3-C8-cikloalkila, fenila, fenoksi i radikala formule C(=Z)Raa, pri čemu Z označava O, S, N(C1-C8-alkil), N(C1-C8-alkoksi), N(C3-C8-alkeniloksi) ili N(C3-C8-alkiniloksi) i Raa označava vodik, C1-C8-alkil, C1-C8-alkoksi NH2, C1-C8-alkilamino ili di(C1-C8-alkil)amino, ili dva radikala Ra vezana za susjedne atome ugljika koji zajedno sa atomima ugljika za koje su vezani također mogu obrazovati zasićeni 5-, 6- ili 7-člani karbociklus, benzolov prsten ili 5-, 6- ili 7-člani heterociklus, koji pored ugljičnih članova prstena ima jedan ili dva heteroatoma izabrana iz grupe koja se sastoji od kisika i sumpora kao članova prstena, pri čemu su karbociklus i heterociklus nesupstituirani ili imaju 1, 2, 3 ili 4 C1-C4-alkil grupe kao supstituente; i poljoprivredno primjenjive soli spoja formule I, osim: 2,6-bis-(5,6-dimetil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-dietil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-dipropil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-diizopropil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-dibutil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-diizobutil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-dipentil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-diheksil-1,2,4-triazin-3-il)piridin; 2,6-bis-(5,6-diheptil-1,2,4-triazin-3-il)piridin; 3-[6-(2,2'-bipiridil)]-5,6-dimetil-1,2,4-triazin; 3-[6-(2,2'-bipiridil)]-5,6-dietil-1,2,4-triazin; 3-[6-(2,2'-bipiridil)]-5,6-dipropil-1,2,4-triazin; 3-[6-(2,2'-bipiridil)]-5,6-dibutil-1,2,4-triazin; 5,6-dietil
Patent HR-P20110169-T1 (HR)
Title: Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection
Inventor: SCALFARO PIETRO
IPC: A61P31/14
Filed: 2011-03-07
Abstract: This invention relates to the use in the treatment of HCV infection, either as single active agents or in combination with another active agent, of a cyclosporin having increased cyclophilin binding activity and essentially lacking immunosuppressive activity.
Patent HR-P20110474-T1 (HR)
Title: Method for flavouring cocoa beans
Inventor: BERNAERT HERWIG
IPC: A23G1/02
Filed: 2011-06-27
Abstract: The present invention relates to a method for flavouring cocoa beans, and to flavoured cocoa beans thereby obtained. In particular, the present invention provides a method for flavouring cocoa beans comprising the step of contacting dried cocoa beans with unroasted, natural flavouring plant material. Said unroasted, natural flavouring plant material preferably includes fruit and/or non-fruit plant material selected from the group comprising herbs, spices, leaves, grasses, flowers and any combinations thereof. The invention further relates to the use of flavoured cocoa beans in food products, and in particular in chocolate products.
Patent HR-P20110505-T1 (HR)
Inventor: BOUKHNY MIKHAILL
IPC: A61B8/10
Filed: 2011-07-06
Abstract: Postupak implementiran na elektronskom računalu za pripremu navođenja do položaja, koji se obavlja kada kirurg postavlja intraokularnu leću (IOL) unutar oka (10), koji obuhvaća sljedeće korake: preuzimanje (72) podataka (28) povezanih s okom u koji se treba implantirati IOL; preuzimanje (72) podataka (28) o planiranom mjestu incizije povezanih s okom u koji se treba implantirati IOL; preuzimanje (72) podataka (28) o induciranom astigmatizmu povezanih s okom u koji se treba implantirati IOL; naznačen time, da se spomenuti podaci (28) koji su predoperativni biometrijski podaci preuzimaju od predoperativnih ispitivanja (68) uključujući sliku oka, topografska mjerenja rožnice i koriste se transmisije za određivanje centra oka; da se dostavljaju predoperativni biometrijski podaci na IOL izračunski softwear program (32) postavljen za izračun položaja i orijentacije IOL-a unutar oka; da se izračunava (76) položaj i orijentacija IOL-a unutar oka; i da se priprema (78) navođenje do mjesta koje obuhvaća sliku kako bi kirurg mogao prosuditi prilikom operacije za implantaciju IOL-a točnu poziciju incizije i pravilno centrirati i postaviti IOL. Patent sadrži još 12 patentnih zahtjeva.
Patent HR-P20120421-T1 (HR)
Title: Binding proteins specific for insulin-like growth factors and uses thereof
Inventor: OLIVIA RAEBER
IPC: A61K39/395
Filed: 2012-05-16
Abstract: Potpuno ljudski izolirani specifični vezni protein koji se po mogućnosti vezuje na inzulinu slične čimbenike rasta II IGF II s križnom reaktivnošćuprema inzulinu sličnom čimbeniku rasta I IGF I i neutralizira aktivnost IGF I i IGF II naznačen time da navedeni vezni protein ili vezni fragment proteina obuhvaća komplementarnu određenu regiju teškog lanca CDR s aminokiselinskim slijedom Ser Tyr Asp Ile Asn SEQ ID NO komplementarnu određenu regiju teškog lanca CDR s aminokiselinskim slijedom Trp Met Asn Pro Asn Ser GlyAsn Thr Gly Tyr Ala Gln Lys Phe Gln Gly SEQ ID NO komplementarnu određenu regiju teškog lanca CDR s aminokiselinskim slijedom Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val SEQ ID NO komplementarnu određenu regiju lakog lanca CDR s aminokiselinskim slijedom Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn His Val Ser SEQ ID NO komplementarnu određenu regiju lakog lanca CDR s aminokiselinskim slijedom Asp Asn Asn Lys Arg Pro Ser SEQ ID NO ikomplementarnu određenu regiju lakog lanca CDR s aminokiselinskim slijedom Glu Thr Trp Asp Thr Ser Leu Ser Ala Gly Arg Val SEQ ID NO Patent sadrži još patentnih zahtjeva
Patent SI-1820494-T1 (SI)
Title: Microparticles consisting of estradiol and cholesterol
Inventor: SAVOIR JOHN CLAUDE
IPC: A61K31/00
Filed: 2004-06-10
Abstract: The invention provides a method for effecting simultaneous contraception and hormone replacement therapy in a female mammal comprising administering to said mammal a pharmaceutical formulation comprising particles of 17-²-estradiol and cholesterol in about a 1:1 molar ratio, and particles of progesterone; wherein the weight ratio of 17-²-estradiol to progesterone is about 1:40.
Patent SI-1689715-T1 (SI)
Title: Tubulin inhibitors
Inventor: BURNS CHRISTOPHER JOHN
IPC: C07D403/12
Filed: 2004-12-03
Abstract: Compounds of general formula (I), (II) (III) and (V) are described      
or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, for use in modulating microtubule polymerisation in a subject.
Patent SI-1961862-T1 (SI)
Title: Paper production with modified solids as microparticles
Inventor: THOMAS HUBBE
IPC: D21H17/69
Filed: 2004-06-30
Abstract: Use is claimed of sulfonic acid- or mercapto-group-containing silica sols as microparticles in papermaking, especially in paper retention. Independent claims are also included for (1) sulfonic acid- or mercapto-group-containing silica sols having a TEM average particle size of 2-45 (especially 2-20) nm or having a sulfur content (based on SiO 2) of 0.1-30 (especially 1-50) mol%; and (2) preparation of these silica sols.
Patent SI-1477126-T1 (SI)
Title: Shape and depth template for incisions with laser tips, particularly usable in bone surgery
Inventor: BERNA NORBERTO
IPC: A61B17/16
Filed: 2004-05-10
Abstract: A shape and depth template for incisions with laser tips, usable in bone surgery, comprising a guiding body (11) for a laser tip (12) provided with two mutually opposite end faces (13) arranged at a preset distance and a lateral surface (14), one of the end faces (13) being arrangeable at the laser tip incision region (15), and with a hole (17) of preset shape that passes therethrough from one end face (13) to the other (13). <IMAGE>
Patent SI-1778537-T1 (SI)
Title: Support rail for a bicycle saddle shell
Inventor: RIONDATO FRANCESCO
IPC: B62J1/00
Filed: 2005-07-28
Abstract: The invention relates to a support rail for a bicycle saddle shell of the type that presents two portions (1', 1'') perfectly symmetrical in relation to the longitudinal plane of symmetry of the saddle. Thanks to its particular shape, both professional and touring cyclists are able to find the saddle always in the same position as previously set before use, even after several stresses due to intense and prolonged saddle use.
Patent SI-1797893-T1 (SI)
Title: Antibodies against phosphorylcholine conjugates
Inventor: DE FAIRE ULF
IPC: A61K47/48
Filed: 2005-04-15
Abstract: The present invention provides a pharmaceutical composition comprising at least one phosphorylcholine conjugate for use in immunization and/or treatment of humans against atherosclerosis or an atherosclerotic related disease.
Patent SI-1965879-T1 (SI)
Title: Process for obtaining alcoholates
Inventor: ECK BERND
IPC: B01D9/00
Filed: 2006-12-13
Abstract: Method for extracting alcoholate through crystallization from the corresponding alcohol solution comprises crystallizing alcoholate at an absolute pressure of at least 3 bar and a temperature of at least 120[deg]C.
Patent SI-1926483-T1 (SI)
Title: Treatment of autoimmune diseases
Inventor: ALBERT RAINER
IPC: A61K31/137
Filed: 2006-09-07
Abstract: The present invention describes certain amino alcohols and phosphate derivatives thereof, and relates to their use to treat particular autoimmune diseases, such as multiple sclerosis, peripheral neuritis, optical neuritis, amyotrophic lateral sclerosis and uveitis.
Patent SI-2136986-T1 (SI)
Title: Method for the production of highly oriented polyolefin ribbons, textiles and technical flexible sheet materials produced therefrom, and the use thereof in protective bodies for the protection from ballistic projectiles and the like
Inventor: BRUNING HANS-JOACHIM
IPC: B29C55/00
Filed: 2008-04-11
Abstract: The invention relates to a method for the production of high-strength ribbons having a high modulus of elasticity made of a highly molecular polyolefin, wherein the polyolefins, particularly polypropylene and polyethylene, are extruded through a slotted nozzle, are then subjected to a temperature of 85° to 135° C. for a duration of at least one second, the films are then cut into individual ribbons, if necessary, and stretched at temperatures between 90° and 165° C. in one or more steps, are rolled up or further processed directly into textiles or technical flexible sheet materials. The ribbons can be laminated into multi-layer flexible sheet materials by using adhesives or adhesion promoters, the flexible sheet materials being particularly suitable as protection from ballistic projectiles. In this case particularly in the form of plate-shaped or flexible compound bodies.
Patent DE-3789859-T2 (DE)
Inventor: KOTHS KIRSTON EDWARD
IPC: C12R1/91
Filed: 1987-10-23
Granted: 1994-09-15
Abstract: A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
Patent DE-3852991-T2 (DE)
Inventor: IJITSU TOSHIKAZU
IPC: C08L71/12
Filed: 1988-11-22
Granted: 1995-06-01
Abstract: A styrene-based resin composition containing (A) a styrene-based resin having mainly syndiotactic configuration and (8) a rubber-like polymer, or further (C) an inorganic filler. The rubber-like polymer (B) includes, for example, (I) polymers produced by polymerizing vinyl monomers in the presence of polymers obtained through polymerization of one or more monomers selected from the group consisting of alkyl acrylate, alkyl methacrylate and polyfunctional monomers having conjugated diene-type double bonds, (II) block or graft copolymers selected from an a-b type block copolymer, an  a-b-a type block copolymer, a b-a-btype block copolymer, an a grafted b copolymer and a b grafted a copolymer and (III) natural or synthetic rubber. The present composition is excellent in heat resistance and further in other physical properties such as impact resistance, stiffness and so on.
Patent DE-3853211-T2 (DE)
Inventor: HIRAI NAOE C O CHEMIRITE LTD
IPC: C01G49/06
Filed: 1988-12-15
Granted: 1995-10-26
Abstract: In a method for producing powdered iron oxide by oxidizing roasting an iron chloride solution, the pH-value of the crude iron chloride solution is adjusted to 2,5 to 4,5, the solution is subjected to a mechanical treatment in order to obtain a solution whose pH-value is not less than 1,5 and which contains insoluble Fe<3><+>compounds in an amount of 0,01 to 0,1 % by weight, being calculated as Fe. The insolubles are separated from the solution and the resulting filtrate or purified solution is then roasted and oxidized in order to produce powdered iron oxide having a P content of not more than 0,005 % by weight.
Patent DE-3873458-T2 (DE)
Inventor: ISHIMOTO ZENICHI
IPC: A63H18/10
Filed: 1988-08-20
Granted: 1992-12-03
Abstract: An apparatus for transferring a running track of a toy car racer in a racing toy is disclosed, in which a motor-driven running body (16) runs on a base (10) having a plurality of guide tracks (12) in parallel, said body having a guide element engageable with said guide track wherein the running body is provided with an electromagentic coil (32) for engaging and disengaging the guide element with the guide track (12), said electromagnetic coil (32) at its pole portions being provided with yokes (40,42) each energizable to a different polarity and protruding in parallel to a predetermined direction to form a pair of magnetic pole portions (44,46), opposite to which is swingably arranged a rod (48) for controlling wheel-steerage, including a magnet (50) at its middle portion so as to arrange adjacently to the magnetic pole portions.
Patent DE-3884162-T2 (DE)
Inventor: BOLDRINI ADOLFO
IPC: F04C28/24
Filed: 1988-11-28
Granted: 1994-05-05
Abstract: A control apparatus for an oil-sealed rotary air compressor. The control cylinder (21) for the intake valve (18) of the compressor (10) can be connected to the oil chamber (12) through a first oil path (23, 28) comprising a servovalve (24) operated by the pressurized oil, and also through a branched-off path (32) comprising an idling valve (25) for switching the compressor into the idling working condition, which is held closed by the same pressure of the oil in the compressor (10), said idling valve (25) comprising fluid operated control means (38) connected to the oil separator (13) through a solenoid valve (40) controlled by a pressure switch (42) which senses the pressure of the air delivered by the compressor.
Patent DE-3887675-T2 (DE)
Inventor: BUCHEGGER FRANZ DR
IPC: A61K49/00
Filed: 1988-12-28
Granted: 1994-06-30
Abstract: The invention concerns novel monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines secreting the antibodies, and processes for the preparation of said cell lines. The monoclonal antibodies of the invention and their derivatives are useful in the diagnosis and therapy of cancer and serial monitoring of cancer patients for recurrent disease or response to therapy. Test kits and pharmaceutical compositions containing said monoclonal anti-CEA antibodies are also subject of the invention.
Patent TR-199902487-T2 (TR)
Title: Arilsekokoladien türevleri
Inventor: BARBIER PIERRE
IPC: C07C35/23
Filed: 1998-04-11
Abstract: A, tek veya çifte bag; B, bir CH2CH2, CH=CH veya C=C; T, bir CH2 veya CH2CH2; R ve R , H veya OH; C(R,R), CH2 veya C=CH2; R , CH3 ve R4H; veya R H ve R4 CH3; L, fenil ve R5 OH veya C(C1-4 alkil)2OH veya L-R5 C(C1-4 alkil)2OH ile 5-sübstitüe edilmis 2-füril oldugu formül (I)'e uygun 24-nor-sekokola-5,7-dien türevleri, D vitaminine bagli bizukluklarin tedavisinde veya engellenmesinde kullanilmaya uygundur; su sartla ki L fenil oldugu zaman A tek bag; B, C=C; T, CH2; R  ve R OH; C(R,R), C=CH2;R , CH3; R4,H;R5, C(CH3)2OH ve R5 orto veya para konumundadir.
Patent DE-60004810-T2 (DE)
Inventor: HAMUNEN ANTTI
IPC: C07C401/00
Filed: 2000-04-27
Granted: 2004-07-01
Abstract: A method for separating sterols from neutral substances comprising the sterols, the method comprising: (a) providing a hydrocarbon fraction containing in the neutral substances; (b) optionally washing the hydrocarbon fraction with water; (c) optionally separating the neutral substances from the hydrocarbon; (d) evaporation fractionating the hydrocarbon fraction from step (a) or step (b), or the neutral substances from step (c), to obtain a sterol-rich fraction; (e) dissolving the sterol-rich fraction in a solvent and crystallizing the sterols from the solvent; and (f) separating the obtained sterol crystals from the solvent.
Patent DE-60005017-T2 (DE)
Inventor: STAMOS P
IPC: A61P37/06
Filed: 2000-06-23
Granted: 2004-06-09
Abstract: The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.
Patent DE-60006243-T2 (DE)
Inventor: DUMITRESCU ANCA
IPC: C08G63/84
Filed: 2000-06-23
Granted: 2004-06-17
Abstract: New lanthanide compound with a tridentate ligand with multiple uses as a catalyst and initiator and/or chain extender in (co)polymerization can be used to give biodegradable polymers. New lanthanide compound with a tridentate ligand is of formula (I); M = lanthanide; RM = H, halogen, (cyclo)alkyl, aryl(oxy), (cyclo)alkoxy, (cyclo)alkylthio, arylthio, amino, (di)alkylamino, (di)cycloalkylamino, alkyl(cycloalkyl)amino, (di)arylamino or (cyclo)alkylarylamino; A, B = 2-4C chain optionally substituted by (cyclo)alkyl or aryl containing halogen, alkyl, NO2 or CN; L1- L3 = E15(R15); E15 = group 15 element; R15 = H, (cyclo)alkyl or aryl optionally substituted by halogen, alkyl, NO2 or CN, group RR'RE14, or SO2R'15; R, R' and R = H, (cyclo)alkyl, aryl(oxy), (cyclo)alkoxy, (cyclo)alkylthio or arylthio, optionally substituted by halogen, alkyl, NO2 or CN; and R'15 = halogen, (halo)alkyl or aryl optionally substituted by (halo)alkyl or halogen. Independent claims are included for the preparation of the above compounds by reacting compounds of formula (L1AL3BL2)<2->2Y<+> and MRmZ1Z2, the preparation of (co)polymers by reaction using the above compound as initiator and/or chain regulator and catalyst and the obtained (co)polymers. Y = H, metal or metallic group; and Z1, Z2 = leaving group.