Patent SG-11201906939X-A (SG)
Title: Interaction between c-peptides and elastin receptor, a model for understanding vascular disease
Inventor: WENSVOORT GERT
IPC: G01N33/564
Filed: 2018-02-05
Abstract: WO 18/ 14197 0 Al Figure 3 V .Y\" rf VGVAPG QGVLPA LGGGPG QGQLPG PGAYPG (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIPO I PCT omit VIII °nolo How ommomo Imo oimIE (10) International Publication Number WO 2018/141970 Al (51) International Patent Classification: GO1N 33/566 (2006.01) GO1N 33/68 (2006.01) GO1N 33/564 (2006.01) (21) International Application Number: PCT/EP2018/052824 (22) International Filing Date: 05 February 2018 (05.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17154889.4 06 February 2017 (06.02.2017) EP (71) Applicant: RESILIUN B.V. [NL/NL]; Hoge Linthorst 1, 7958 NZ Koekange (NL). (72) Inventor: WENSVOORT, Gert; Hoge Linthorst 1, 7958 NZ Koekange (NL). (74) Agent: WENSVOORT, Gert; Kallenkoterallee 82 A, 8331 AJ Steenwijk (NL). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: INTERACTION BETWEEN C-PEPTIDES AND ELASTIN RECEPTOR, A MODEL FOR UNDERSTANDING VASCU- LAR DISEASE (57) : The invention shows that inflammation in metabolic syndrome is augmented by a hitherto overlooked lock- and-key activation of the elastin recep- tor, a protein involved in vascular (blood vessel) inflammation and elastin repair, with the C-peptide, a small protein that is produced in a 1:1 ratio alongside with widely known insulin. The elastin receptor is the lock that is activated by a key motif of amino acids (PG-domain) found in C-peptide and in breakdown products (PG- domain-fragments) thereof. Until now, no one has ever discovered this lock- and-key interaction between the two, now providing novel inroads in diagnosis, prevention and development of novel compounds for treatment of metabolic syn- drome, exploiting the finding that not only the normal keys of the elastin receptor (elastin peptides), but also the C-peptide, a peptide we produce together with in- sulin every time glucose rises in our blood after a meal, interacts in a lock-and- key mode with the elastin receptor.