baber/WOPTO huggingface dataset:
Patent DO-P2021000101-A (DO)
Title: Anticuerpos humanizados contra c-kit
Inventor: JIE LIU
IPC: C07K16/40
Filed: 2021-05-25
Abstract: La invención proporciona anticuerpos que se unen específicamente a c-Kit y métodos para usar dichos anticuerpos en la sustitución de células madre y el tratamiento del cáncer.
Patent DO-P2022000270-A (DO)
Title: Derivados de tetrazol como inhibidores de trpa1
Inventor: JENS WILLWACHER
IPC: A61K31/54
Filed: 2022-11-30
Abstract: La presente divulgación proporciona algunos derivados de tetrazol que son inhibidores de potencial de receptor transitorio anquirina 1 (TRPA1) y que, por ende, son útiles para el tratamiento de las enfermedades que se pueden tratar mediante inhibición de TRPA1. Asimismo, se proporcionan composiciones farmacéuticas que lo contienen, y procesos para la preparación de dichos compuestos.
Patent EC-SP12012056-A (EC)
Title: Derivados de 3-hidroxi-5-arilisotiazol novedosos
Inventor: KOSUGA NAOTO
IPC: C07D417/14
Filed: 2012-07-23
Abstract: Proporcionar un agente que activa GPR40 que tiene, como un ingrediente activo, un compuesto novedoso que tiene una acción agonista GPR40, una sal del compuesto, un solvato de la sal o el compuesto, o similares, particularmente, un secretagogo de insulina y y un agente terapéutico y/o profiláctico contra diabetes, obesidad, u otras enfermedades.Medios para solucionar el problemaUn compuesto de la Fórmula (I): donde n es 0 hasta 2; p es 0 hasta 4; j es 0 hasta 3; k es 0 hasta 2; un anillo A es un grupo arilo que está opcionalmente sustituido con L o un grupo heterocíclico que está opcionalmente sustituido con L; un anillo B es un anillo de benceno, un anillo de piridina, o un anillo de pirimidina;X es O, S, -NR7-; y R1 hasta R7 son grupos específicos,una sal del compuesto, o un solvato de la sal o el compuesto.
Patent EC-SP13012627-A (EC)
Title: 1h-pirazol-5-olato sódico sustituido
Inventor: MILITZER HANS CHRISTIAN
IPC: C07D403/14
Filed: 2013-05-16
Abstract: La presente solicitud se refiere a 1-[6-(morfolin-4-il)pirimidin-4-il]-4-(1H-1,2,3-triazol-1-il)-1H-pirazol-5-olato sódico, a procedimientos para su preparación, su uso para el tratamiento y/o la profilaxis de enfermedades como también su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente de enfermedades cardiovasculares y hematológicas, de enfermedades renales como también para ayudar a la curación de heridas.
Patent GB-189704610-A (GB)
Title: Improvements in Explosion Motors.
Inventor: EMBLETON CHARLES ANDREW
Filed: 1897-02-20
Granted: 1898-01-29
Abstract: 4610. Embleton, C. A. Feb. 20. Connecting - rods; crossheads. -An explosion motor to be driven by petroleum and air, coal gas and air, or other explosive mixture, consists of eight single-acting cylinders D in two sets of four, each set working on aT-shaped crosshead and connecting - rod H which drives a crank shaft I. Each piston-rod F is common to two pistons E, and is connected to one of the rods H by a perforated pin G, as shown. The rods H turn on a shaft M mounted in brackets sliding on the guide-bars L.
Patent GB-189708085-A (GB)
Title: Improvements in Blocks and Tackles.
Inventor: BOSKE THEODORE
Filed: 1897-03-29
Granted: 1897-05-22
Abstract: 8085. Boske, T. March 29. Pulley-blocks.-The rope A, which may be a clothes line, passes round a pulley C in a block B, against which bears a pivoted cam D. The cam is fastened by a short rope to the post. When therefore the cord B is tightened by a pull it is automatically locked. The cam is prised away to lower the line.
Patent GB-189708278-A (GB)
Title: Improvements in Saddle Supports for Bicycles.
Inventor: CRANE CHARLES ALBERT
Filed: 1897-03-31
Granted: 1898-03-19
Abstract: 8278. Crane, C. A. March 31. Saddle supports for bicycles. Alternate rings of wood and india-rubber C, D are placed in the saddle post, or in a tube which fits therein, to form a spring support. When a separate tube is used, a collar F formed thereon rests on the bead of the saddle post. A cane A, passing through the rings C, D and secured to the lower one, serves to lift them out of the tube when desired. The saddle pin rests on a metal ring B placed on the buffer. It may be free to rotate, or its rotation may be limited by a lug on the collar F engaging a longitudinal slot formed in the saddle pin. In a modification, the buffer is composed of discs of wood placed between india-rabber spheres.
Patent GB-189709498-A (GB)
Title: Improvements in the Mode of Making the Groove which Holds the Wire that Fastens in, or Fixes, the Glass Silver or Metal Hand or Table Mirrors.
Inventor: MYATT WILLIAM JAMES
Filed: 1897-04-14
Granted: 1898-03-19
Abstract: 9498. Myatt, W. J. April 14. Looking-glasses and mirrors.-The groove to receive the ring or wire A which fixes the glass in a ladies' toilet h a n d mirror &c. is stamped, pressed, or spun in the material of the bevel B itself, instead of being cut out of a soldered or strengthening ring as usual.
Patent GB-189714509-A (GB)
Title: Improvements in Lamps for Bicycles and other Vehicles.
Inventor: HOLMES JOHN
Filed: 1897-06-15
Granted: 1897-09-18
Abstract: 14,509. Holmes, J. June 15. Velocipede &c. lamps.-Both the lens-holder b and the reservoir h are hinged to the body a, and are fastened in position by sliding pins ; the jewels or side lights are secured by clips a<4>; and the lamp is lit by inserting a match through a tube which has a striking-surface in proximity to the wick-tube. The crown f is sprung into position upon the neck e, into which is also sprung a disc g, which checks the escape of the products of combustion and prevents the flame from flickering ; the disc g and the enlargements d<2> on the reflector d prevent light from escaping through the ventilating-apertures a<6>, f<1>, f<2>. The arms l<1> of the anti-vibration device are secured by catch-plates p<2>, against which the ends n of the springs bear. A spring r<1> is arranged within the socket r.
Patent GB-189714857-A (GB)
Title: Improvements in Barbed or Armed Fencing or Railing.
Filed: 1897-06-19
Granted: 1898-04-23
Abstract: 14,857. Gare, T., and Berry (Limited). June 19. Fencing.-A barbed bar or rod as shown in Fig. 5 for forming a fence is produced by twisting a rod formed as shown in Fig. 3. The rod is first rolled with a suitable section, and the teeth bare then formed by punching out the interapaces.
Patent GB-189716082-A (GB)
Title: An Improved Slate Cleaner or Rubber.
Inventor: LONGMORE ELIZABETH ANN
Filed: 1897-07-06
Granted: 1897-08-07
Abstract: 16,082. Longmore, E. A. July 6. Slates, cleaners for. A wooden block A faced on one or both sides with leather or rubber B is used for cleaning school slates.
Patent GB-189720564-A (GB)
Title: An Improved Tube for Colours.
Inventor: PALMIE CHARLES JOHANNES
Filed: 1897-09-07
Granted: 1898-07-30
Abstract: 20,564. Palmie, C. J. Sept. 7. Tubes or containers, collapsable.- Receptacles for oil colours, distempers, and water colours are formed of a bag a of animal bladder, rubber, oilcloth, &c., which is secured to a socket b by tying its neck into a groove on the outside of the socket by means of a wire, string, or the like d. Any colour deposited or separated in the bag is readily remixed with the medium by suitably pressing the bag with the hand.
Patent GB-189801813-A (GB)
Title: Improvements in the Construction of Window Frames and their Sashes.
Inventor: CRAIG JOHN
Filed: 1898-01-22
Granted: 1898-11-12
Abstract: 1813. Craig, J. Jan. 22. Windows. -Relates to sliding sashes adapted to turn inwards for cleaning &c. The lower portions of the inner beads D are hinged or secured by clamping-screws, the lower halves of the parting beads are cut away, and the pulley stiles are rabbeted to act as guides for the lower sash, and allow the upper sash to be turned inwards. The sash stiles B are rabbeted for two-thirds of their length to clear the sash cords F, which run under guide-pulleys A above the middle of the frame when the sashes are pulled into the room.
Patent GB-189802207-A (GB)
Title: Improvements in Wringing and Mangling Machines.
Inventor: KENYON RICHARD WALTON
Filed: 1898-01-27
Granted: 1898-11-05
Abstract: 2207. Entwisle & Kenyon and Kenyon, R. W. Jan. 27. Mangling and wring- i n g machines. - The lower rail B of the drip - board A is inclined inwards as shown. Two modifications are described, in one of which the rail is curved, and in the other the ledge is in the form of an inverted wedge.
Patent GB-189805838-A (GB)
Title: Improvements in and relating to the Driving Gear of Cycles.
Inventor: LUTHER WILLIAM HENRI
Filed: 1898-03-10
Granted: 1899-02-04
Abstract: 5838. Luther, W. H., and Cockburn, J. March 10. Driving-mechanism.-Figs. 1 and 2 show the application of the invention to a bicycle. Longitudinal members A are provided on each side of the rear wheel, and are connected by a cross-tube upon which rotates the rear wheel hub and within which rotates the wheel spindle. Cranks c are secured to the ends of the wheel spindle, and are provided with pins c<1> connected to the upper ends of links d secured to or formed with the treadle-levers d'. At the front end the levers d' are provided with pedals d<2>, and at the rear end they are connected to swinging links e pivoted to the frame. A toothed wheel g mounted upon the wheel spindle gears with a pinion g' mounted upon a stud-axle which also carries a wheel h gearing with a pinion h<1> on the hub of the rear wheel. The gear-wheel g may replace one of the cranks. Instead of toothed gearing, friction gearing may be employed. A mounting-step may be fitted on one of the treadle-levers. In a modification, the rear ends of the levers d<1> are curved upwards and fitted with rollers to work in guides in the frame. In another arrangement, the crank-pins work in slots in the levers d<1> and the rear ends of the levers have their fulcrums in slots in the frame.
Patent GB-189809299-A (GB)
Title: Improvements in or relating to Overhead Trolley Wires for Electric Traction, Overhead Electric Cables or other Wires.
Inventor: HACKING ROBERT
Filed: 1898-04-22
Granted: 1899-04-22
Abstract: 9299. Hacking, R. April 22. Electric railways and tramways with overhead conductors. Conductors.-Relates to means for cutting out of circuit a length of broken trolley wire, electric cable, or other conductor. The ends of the wires at each support are attached to levers C pivoted on a base B of insulating-material or otherwise insulated therefrom. The circuit between these levers C is completed by a second pair of levers E, which are electrically connected, but the circuit is broken by the insulated part I when the lever C tilts owing to breakage of the conductor. In that case, and also when a lever C is withdrawn, the lever E rises or falls into contact with a contact K from which a shunt circuit, which may be through the guard wires, is completed to the adjacent support. For electric railways the part M between the lever C is electrically connected to the levers E, and forms a continuation of the track for the trolley.
Patent GB-189810148-A (GB)
Title: Improvements in Time Checking and Recording Apparatus for Workmen and the like.
Inventor: DEUEBNER JOHN W
Filed: 1898-05-03
Granted: 1898-11-12
Abstract: 10,148. De³bner, J. W. May 3. Time-printing stamps. -Relates to time-checking apparatus for workmen. Hour and minute type-wheels F<1> are driven from a weight motor barrel G<1>, the minute - wheel b e i n g actuated by wheels and pinions, and the hourwheel by the pawl H<4> on a bell-crank spring lever H<1>, R<3> moving a ratchet-wheel H<5> every hour under the action of a cam H. H<6> is a locking-pawl to control the movement. The escapement - wheel G<8> has an anchor g<12> which, through the connecting- rod g<4>, bell-crank lever g<5>, and pitman g<6> is rocked by an ordinary clock in the upper part of the apparatus (not shown) so as to allow the minute - wheel to advance suddenly each minute. The workman rests his hand upon a pivoted shelf B in order to sign through a slit A<5> upon a paper strip passing from the roll E over a printing-platen d<5>, a writing-table d<2>, and thence to the winding-on roll E'. The table and platen, with the rolls, are carried by a pivoted frame D, which can be rocked into either of the positions shown in dotted lines, but is normally held in the intermediate position by a spring. As the shelf is depressed, the arm I acts upon an inking-device J<3>, J, j', and, after pressing it upon the type, slips past it ; the sliding bar I', which is pivoted to the arm I, next brings its stud i<2> against a lever I<2> which, striking a stud i<3> on the frame D, depresses it to take an impression from the type-wheels ; lastly, the stud i<4>, acting directly on the frame, throws it into its extreme position with the table d' under the slit A<5>. This movement, by means of a pawl K<1> on the casing of the apparatus engaging a ratchet K, turns the winding-on roller E<1> so as to advance the strip and bring the time record alongside the slit A<5>, where it can be observed by the workman as he signs. The forward movement of the bar I<1> may act on a lever L carrying a pawl L<1> for turning the barrel G<1> and winding up its weight G<2>. The cord itself is arranged to act upon an arm l<1> and throw the pawl out of action when the weight reaches its highest position. In a modified form, the workmen are provided with keys having numbered type and the whole action is effected by pushing the key into a slot in the front of the case. The details of construction in this form are considerably modified, and an alarm bell is provided to call attention to the actuation of the apparatus.
Patent GB-189810930-A (GB)
Title: Improvements in or relating to Clips for Velocipede Saddles.
Inventor: VAUGHAN WALTER
Filed: 1898-05-13
Granted: 1898-08-20
Abstract: 10,930. Vaughan, W. May 13. Saddle clips.-A split bush E, N for embracing the L-pin is placed within a box C fitted at its ends with recessed plates 0 for gripping the framing wires. The split bush is provided with a rib F which engages a slot D in the box C, and also with projecting lugs G between which engages the flat head of a bolt I. When the nut on the bolt I is screwed up, the bush E is contracted and caused to grip the L-pin. The plates 0 are pivoted at R and gripped against the ends of the box C by bolts and nuts S, and the lower ends of the plates are slotted to allow the saddle to be tilted.
Patent GB-189814142-A (GB)
Title: Improvements in Coupling Devices for Safety Bicycles and the like.
Inventor: JOURDAN AUGUSTE
Filed: 1898-06-25
Granted: 1899-04-29
Abstract: 14,142. Jourdan, A., and Kahn, F. June 25. Coupling, arrangements for.-Relates to means for coupling tandem and other bicycles &c. As shown in plan in Fig. 1, the bicycles are connected by three transverse tubes 1, 2, 3 fixed to the heads, seat pillars, and rear forks respectively. The two bars 1 and 2 are also connected by an adjustable stay 4. The steering-forks are coupled by a tube 5 with pivoted arms at its ends. The tubes 1, 2, 3, 5 are each made in two parts connected by a slot and screw to allow a limited amount of play, and are provided at the ends with sockets fitted with swivelling &c. screw or like clamps for securing them to the frames. The tube 2 is curved as shown, or in an equivalent manner, to give clearance. The stay 4 is adjustable in length by means of a right and left handed screw coupling connecting the two tubes of which it is composed. When not in use, the parts of the tubes may be closed telescopically to reduce the space they occupy. The tubes are made of steel, aluminium, &c., and the sockets of bronze.
Patent GB-189817696-A (GB)
Title: Improvements in Kilns for Burning Cement-making Materials and for similar purposes.
Inventor: SWAN JOHN CAMERON
Filed: 1898-08-16
Granted: 1899-11-16
Abstract: 17,696. Swan, J. C. Aug. 16. Kilns. - Relates to kilns for drying and burning cement-making materials, in the form of slurry or otherwise, applicable also for other purposes. Fig. 1 shows a cement kiln for the treatment of slurry which is fed into drying - tubes a, a. The material then passes through the portion c of the kiln to the w a t e r - jacketed section d, where it is burnt by the heat of combustion of gaseous f u e l supplied from a water-jacketed gas producer or furnace e. The material, in the form of clinker, descends through the cooling-chamber g and is withdrawn at i. Air entering at h becomes heated in the process of cooling the clinker and serves to support combustion. Additional air may, if required, be admitted at f. The kiln may be worked under natural or forced draught. In the latter case, the ashpit of the producer has a water-seal as shown.
Patent GB-189818968-A (GB)
Title: Improvements in Screw Propellers for Preventing Slip in Water and Air.
Inventor: BUCHANAN FREDERICK
Filed: 1898-09-06
Granted: 1899-10-06
Abstract: 18,968. Buchanan, F. Sept. 6. Screw propellers.-The blades of screw propellers are finely grooved, as shown, to prevent slip. The grooves are inclined at an angle of about 30‹ with the centre line of the blade.
Patent GB-189911222-A (GB)
Title: Process for Making Chocolate Preparations.
Inventor: BECHTOLD JEAN
Filed: 1899-05-30
Granted: 1899-10-28
Abstract: 11,222. Bechtold, J. May 30. Chocolate preparations.-A wine chocolate extract is prepared as follows:-Cocoa powder and sugar are mixed together with the addition of cream and water, and the whole is then boiled until it forms threads. Crystallized citric acid is then added, and the whole allowed to cool. When the mixture is cold, spirits of wine, alcoholic extract of tonga beans, &c. or rum is added. A chocolate extract is prepared by leaving out the citric acid and the spirits of wine &c. and adding more cream.
Patent GB-189918621-A (GB)
Title: Improvements in Sliver Cans and in Machines for Manufacturing the same.
Inventor: SUTCLIFFE JAMES ANDERTON
Filed: 1899-09-15
Granted: 1899-11-11
Abstract: 18,621. Sutcliffe, J. A. Sept. 15. Metal, sheet, seaming and j o i n i n g ; corrugating. - Sliver cans with buffer bottoms, such as those described in Specifications No. 12,888, A.D. 1889, and No. 28,002, A.D. 1897, [both in Abridgment Class Spinning], are corrugated by means of the apparatus shown in Fig. 5. Two rollers d', d, one formed with suitable projections and the other with corresponding recesses, are mounted side by side or one above another in a suitable frame, and rotated by gearing g. To facilitate the insertion of the can between the rollers &c., the front bearing of the upper roller is arranged to be withdrawn from the corresponding bearing of the lower one by means of a screw f. The binding- ring j<2> of the can may be united to the body j thereof by passing the lower part of the body into the binding-ring, or the ring into a socket j<1> formed on the body and securing the two parts together by riveting or by corrugating the two parts at the place where they overlap.
Patent GB-189919070-A (GB)
Title: Improvements in Guards for Circular Saws.
Inventor: DREW SYDNEY
Filed: 1899-09-22
Granted: 1900-01-06
Abstract: 19,070. Drew. S. Sept. 22. Sawing.-Relates to a guard for circular saws, consisting of a steel or other metal plate C, which is clamped by a bolt g to a bracket d behind the saw bench. The plate C is slightly thicker than the saw, except at the edge c, which is bevelled off. An extension piece c' is bolted to the plate C, to protect the front of the saw, and is fitted with a roller l to run on the wood.
Patent GB-189920842-A (GB)
Title: An Improved Game.
Inventor: SCHROEDEL JOHANN GEORG
Filed: 1899-10-18
Granted: 1899-11-18
Abstract: 20,842. Schr÷del, J. G. Oct. 18. Games played with balls and boards.-In combination with a board in which are a series of recesses or grooves 4, a lever 1 is provided such that, on a ball 5 being placed on the inner end 3 of the lever, the ball can be thrown up and dropped into one or other of the numbered recesses. Instead of the ball and recesses, a ring and pegs can be used.
Patent GB-189921046-A (GB)
Title: Improvements in or relating to Driving Gear and Brakes for Velocipedes and the like.
Inventor: DEAKIN THOMAS
Filed: 1899-10-21
Granted: 1900-09-29
Abstract: 21,046. Deakin, T., and Deakin, C. H. Oct 21. Driving-mechanism ; clutches; brakes; tricycles.- Relates to various forms of clutch, back-pedalling brake, and two-speed driving-mechanism &c. In one form of clutch, the outer part forming the chain-wheel &c. carries a series of pivoted pawls forced into engagement with ratchet teeth on the inner part by a serpentine spring. The chainwheel is sometimes made in segments 7, Fig. 3, which are pivoted on pins 8 carried by side plates 9, all or some of the segments being formed with pawls 5 to engage teeth 3 on the hub &c. 2. In a modification, the segments are formed with lateral pawls which engage teeth on flanges carried by the hub, ball bearings being arranged between the segments and the hub. In another form of clutch, pawls 5, Fig. 7, work in recesses in the inner part 2 of the clutch, and engage internal teeth 3. The pawls are connected by links 13 with the outer part 4. A similar clutch is used for a backpedalling brake, but in this case the pawls are connected to the outer part by short links as well as by the long links 13, and are arranged to act frictionally on the flange of the inner part. Fig. 9 shows a rear-wheel back-pedalling brake. The chain-wheel 4, fitted with a free-wheel clutch 5, has formed on its face a series of inclined recesses in which work clutch balls 23. During backpedalling, these balls rise in the recesses, so as to press on the disc 20 and thus move the outer part 15 of the hub on the fixed part 16, so as to cause a disc 19<1> to bear on a stationary disc 24. Fig. 11 represents an arrangement of sun-andplanet wheels forming a two-speed gear. The three-armed crank 32 carries pinions 39 gearing with a sun-wheel 36 and internal teeth on the chain-wheel &c. 40. The sun-wheel can be held stationary for speed by a sliding bolt 43 operated oy a lever thiough bridle rods, or can be locked - to the crank for power by a toothed clutch piece 52 actuated through a rod 34 by a plate 31 on the crank end, the plate 31 being movable by the rider's foot. In a modification, a sliding piece on the crank is arranged to lock the spindle of one of the planet pinions, so that the gear moves as a whole. This arrangement may be used as a substitute for or in addition to the arrangement for locking the sun-wheel. According to the Provisional Specification, the driving-mechanism consists of a wire &c. rope working on grooved pulleys and provided with guide-pulleys &c. This arrangement is stated to be applicable centrally to a cycle with a single front-steering and two rear-driving wheels arranged close together. A back-pedalling cone brake actuated through a clutch, a two-speed gear consisting of two sets of chain or rope gearing thrown in and out of action By a clutch, and a two-speed gear consisting of two sets of internal gearing actuated through connecting-rods are also described in the Provisional Specification. I
Patent GB-189922682-A (GB)
Title: A Reversible Corset.
Inventor: ROSCOE ADA AUGUSTA
Filed: 1899-11-14
Granted: 1900-01-13
Abstract: 22,682. Roscoe, A. A. Nov. 14. Corsets are made so that they can be worn with either side outwards.
Patent GB-190001996-A (GB)
Title: Device for Stopping Leaky Joints in Gas or other Pipes.
Inventor: DRESSER SOLOMON ROBERT
Filed: 1900-01-31
Granted: 1900-03-31
Abstract: 1996. Dresser, S. R. Jan. 31. Spigot-and-socket joints.-Relates to means for stopping leaky joints in gas or other pipes, especially applicable to spigot-and-socket joints. The repairing-device is shown in Fig. 1, and is shown applied to a spigot-and-socket joint in Fig. 2. The clamp ring A is formed in two parts with stepped ends, and is provided with holes for the bolts a<4>, which have polygonal heads and lateral projections a<14> to engage with the socket of the joint. Walls or flanges a<15> retain the bolts in position. The annular recess a<9> receives a packing-ring a<10> of rubber or other suitable material.