baber/WOPTO huggingface dataset:
Patent CA-2234609-A1 (CA)
Title: 2-amino-6-anilino-purine derivatives and processes for their preparation
Inventor: IMBACH PATRICIA
IPC: A61P35/00
Filed: 1996-10-22
Abstract: 2-Amino-6-anilino-purine derivatives of the formula I (see formula I) in which q is 1-5, R1 is halogen, lower alkyl, hydroxyl or lower alkanoyloxy; lower alkoxy which is unsubstituted or substituted by hydroxyl, lower alkoxy or carboxyl; a radical of the formula -O(-CH2-CH2-O)t-R6, in which t is 2-5 and R6 is hydrogen or lower alkyl; carboxyl, lower alkoxycarbonyl, piperazin-1-yl-carbonyl or carbamoyl; N-lower alkyl-carbamoyl, which is unsubstituted or substituted by hydroxyl or amino in the lower alkyl moiety; N,N-di-lower alkyl-carbamoyl, cyano, nitro, amino, lower alkanoylamino, lower alkylamino, N,N-di-lower alkylamino, aminosulfonyl or trifluoromethyl, where, if more than one radical R1 is present in the molecule, these can be identical to or different from one another, R2 is hydrogen, carbamoyl or N-lower alkyl-carbamoyl, m and n are each 0 or 1, where m is 0 if n is 1 and m is 1 if n is 0, R3 is lower alkyl or phenyl which are unsubstituted or in each case substituted by hydroxyl, lower alkoxy, amino, lower alkylamino or N,N-di-lower alkyl amino, and a) R4 is hydrogen, amino, phenylamino, lower alkylamino, hydroxyl, phenoxy, lower alkoxy, acyl having 1-30 C atoms, a substituted aliphatic hydrocarbon radical having not more than 29 C atoms, a carbocyclic radical having not more than 29 C atoms or a heterocyclic radical having not more than 20 C atoms and not more than 9 heteroatoms and R5 is amino, phenylamino, lower alkylamino, hydroxyl, phenoxy, lower alkoxy, acyl having 2-30 C atoms, a substituted aliphatic hydrocarbon radical having not more than 29 C atoms, a carbocyclic radical having not more than 29 C atoms or a heterocyclic radical having not more than 20 C atoms and not more than 9 heteroatoms, or b) R4 and R5 together are a substituted or unsubstituted alkylene or alkenylene radical having in each case not more than 15 C atoms, in which 1-3 C atoms can be replaced by oxygen, sulfur or nitrogen, and their salts are described.        These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and can be used for treatment of hyperproliferative diseases, for example tumour diseases.
Patent CA-2234688-A1 (CA)
Inventor: BUNGER JAMES W
IPC: C01F11/18
Filed: 1996-10-10
Abstract: A solution process for the purification of calcium hydroxide, particularly from hydrated carbide lime, which is subsequently used as a feed stock for a high-value calcium product, preferably calcium carbonate. Precipitated calcium carbonate is formed by reaction of the purified calcium hydroxide solution with carbon dioxide in a plug-flow reaction system.
Patent CA-2234920-A1 (CA)
Title: Safety coupling for rotary pump
Inventor: MILLS ROBERT A R
IPC: E21B43/12
Filed: 1998-05-11
Abstract: A safety coupling for preventing backspin at excessive speeds of a torque transmitting drive powering a drive string which stores reactive torque due to torsional stress. The safety coupling includes a rotatable driving member to be coupled with a torque producing power source, a rotatable driven member to be coupled with the drive string for axial rotation therewith. The driven member is movable relative to the driving member between an engaged position wherein the driving and driven members are coupled by a torque transfer structure to provide a positive driving connection between the torque transmitting drive and the shaft, and a disengaged position wherein the driving and driven members are freely rotatable relative to each other so that back-spin of the torque transmitting drive is prevented. The driven member is biased into the disengaged position and forced into the engaged position only during forward rotation of the shaft. To start rotation of the shaft, the coupling further includes an auxiliary coupling component which transfers a selected torque between the driving and driven members for start-up of the shaft from standstill and to force the driven member into the engaged position. However, the amount of torque transmitted by the auxiliary coupling component is less than the torque required for build-up of sufficient reactive torsion to create a potentially hazardous back-spin. Thus, the auxiliary coupling component is disengaged before potentially dangerous levels of reactive torsion are stored in the shaft, which prevents potentially hazardous back-spin, should the main coupling components of driving and driven member and torque transfer structure fail. The coupling substantially prevents damage to the torque transmitting drive upon excessive back-spin of the drive string and reduces the risk of injury to personnel working in the vicinity of a drive string storing elastic torsion. The coupling is preferably part of a safety arrangement including the coupling, a brake for slowing back-spin of the shaft created upon interruption of power to the shaft, and a common control member for controlling both the operation of the coupling and the brake.
Patent CA-2234975-A1 (CA)
Inventor: SMITH WALTER P
IPC: A61Q19/06
Filed: 1996-10-17
Abstract: De nouveaux traitements appliqués localement sur des peaux abîmées ou vieillies, se sont avérés, au moyen de données de comparaison, apporter une amélioration de la structure de peaux abîmées, comme le montrent des données d'épaississement de la peau. Ces traitements rompent la barrière d'hydratation de la peau, élèvent la perte d'hydratation transépidermique (TEML) pendant des durées prolongées portant sur des semaines ou sur des mois et consistent en des procédés mécaniques, tels que la dermoabrasion, ou à base de solvant, tels que des lavages à l'acétone. Des traitements préférés mettent en application des crèmes ou des gels cosmétiques comportant des ingrédients actifs, tels que de l'acide lactique en tant que premier agent soluble dans l'eau de rupture de barrière, un rétinoïde, par exemple, palmitate contenant de la vitamine A en tant qu'agent de rupture de barrière soluble dans les lipides, ainsi qu'un cérébroside spécial servant à inhiber la réparation de la barrière. On peut appliquer quotidiennement ces crèmes oucces gels pendant des durées prolongées, de manière à réaliser une rupture chronique et prolongée de la barrière, prouvée par un TEML considérablement élevé. Nouvelles formulations cosmétiques dont le but est d'améliorer l'aspect et la structure de zones faciales sensibles de la peau.
Patent CA-2241843-A1 (CA)
Title: Plate-type crossflow air-to-air heat exchanger having dual pass cooling
Inventor: STARK WALTER
IPC: F24F12/00
Filed: 1996-09-12
Abstract: A heat exchanger (40) for dehumidifying a stream of air including heat conducting channel walls (42) which serve as the heat exchange surface for precooling and reheating air during the dehumidification process. Cooling conduits (48) are positioned in a plane parallel to a plane defined by the heat conducting walls (42), such that cooling occurs both in the intake and exhaust airstreams, and the airflow is redirected in a small plenum chamber (44) located at an end of the channels adjacent the cooling conduits (48). A  system is also provided which includes a plurality of heat exchangers in series sharing a common cooling coil and a common plenum chamber.
Patent CA-2242261-A1 (CA)
Title: 5-[(heteroaryl)alkyl]-3-0x0-pyrido[1,2-a]benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
Inventor: FITZPATRICK LOUIS J
IPC: A61K31/435
Filed: 1998-06-30
Abstract: A compound of the general formula 1;       is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
Patent CA-2243123-A1 (CA)
Title: Steel products excellent in machinability and machined steel parts
Inventor: WATARI KOJI
IPC: C22C38/04
Filed: 1997-11-25
Abstract: The present invention is directed to steel products which exhibit excellent machinability and are suitable for steel stocks of structural steel parts for a variety of machinery, such as transportation machinery including automobiles, machinery for industrial use, construction machinery, and the like; as well as to a variety of machined structual steel parts for machinery such as crankshafts, connecting rods, gears, and the like. The steel products of the present invention are endowed with excellent machinability and have the following composition based on % by weight: C: 0.05% to 0.6%; S: 0.002% to 0.2%; Ti: 0.04% to 1.0%; N: 0.008% or less; Nd: 0% to 0.1%; Se: 0% to 0.5%; Te: 0% to 0.05%; Ca: 0% to 0.01% Pb: 0% to 0.5%; and Bi: 0% to 0.4%; wherein the maximum diameter of titanium carbosulfide contained in the steel is not greater than 10 µm, and its amount expressed in the index of cleanliness of the steel is equal to or more than 0.05%. The machined parts, according to the present invention, are manufactured by subjecting the steel products of the invention to a machining process, and are useful as structural steel parts for a variety of machinery, such as transportation machinery including automobiles, machinery for industrial use, construction machinery, and the like.
Patent CA-2243234-A1 (CA)
Title: 5h-thiazolo[3,2-a]pyrimidine derivatives
Inventor: ADAM GEO
IPC: A61K31/00
Filed: 1998-07-15
Abstract: The invention is concerned with compounds of the general formula (see formula I) wherein R1 signifies hydrogen, lower alkyl, phenyl or benzyl, R2 signifies lower alkyl, lower alkoxy, -O(CH2)n N(R13)(R14), -(CH2)n N(R13)(R14) or -N(R15)(CH2)n N(R13)(R14), R3-R12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cyclo-alkyl, lower alkoxy, hydroxy, nitro, cyano, -N(R13)2, phenyl, phenyloxy, benzyl or benzyloxy, or R6 and R7 together signify a benzene ring, R13-R15 signify hydrogen, lower alkyl or cycloalkyl and n signifies 1-5, as well as their pharmaceutically acceptable salts.   These compounds are suitable for the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, chronic pain, dyskinesia and depressions.
Patent CA-2244642-A1 (CA)
Title: Adaptive monoski frame
Inventor: BARTLETT RUSSELL
IPC: A63C5/00
Filed: 1998-08-10
Abstract: A mono-ski frame adapted for skiing in the sitting position and designed to allow a rearward and downward traverse of the upper portion of the frame relative to the lower portion during loaded conditions to enhance the carvability during the turn. The mono-ski frame includes a lower frame having a forward end and a rearward end adapted to be attached to a ski. A foot rest is attached to the forward end of the lower frame. An upper frame having a seat mounted thereon is moveable relative to the lower frame via a first link arm. The first link arm is pivotally attached at a first position to the lower frame and at a second position to the upper frame, wherein the first position is located forwardly of the second position so that the seat attached to the upper frame travels in a rearward direction under loaded conditions. A shock absorber adapted to minimize the transfer of vibration between the lower frame and the upper frame is coupled between the upper and lower frames and includes a piston assembly and a spring coupled to the piston assembly for biasing the piston assembly toward an extended uncompressed position.
Patent CA-2244729-A1 (CA)
Title: Device for processing a strand of plastic material
Inventor: MERRITT MARK W
IPC: B26D3/16
Filed: 1997-01-28
Abstract: A device is disclosed for constricting a strand (2) of plastic material, seaming a coating and stripping said strand, in particular a multilayer extruded strand, at predetermined intervals using a tool (3, 4) comprising a number of segments (35-40) which can be displaced towards one another in two detachable sections (31, 32) each of which contains a portion of the segments (35, 40).
Patent CA-2245712-A1 (CA)
Title: Transdermal transport using ultrasonic standing waves
Inventor: SHAIN ERIC B
IPC: A61M37/00
Filed: 1997-02-14
Abstract: A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.
Patent CA-2246000-A1 (CA)
Inventor: JEUNEHOMME SYLVIE
IPC: B61G5/02
Filed: 1998-10-01
Abstract: La présente invention porte sur une articulation d'accouplement entre deux véhicules (A, B), notamment ferroviaires, reposant sur un bogie médian entre lesdits deux véhicules, ladite articulation d'accouplement présentant une fonction de rotation et une fonction d'amortissement, caractérisé en ce que chaque fonction de rotation et d'amortissement est réalisé par des éléments distincts.
Patent CA-2247207-A1 (CA)
Title: Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
Inventor: CAMBIER JOHN C
IPC: G01N33/50
Filed: 1996-02-28
Abstract: The present invention is directed to a novel product and method for regulating hematopoietic cell function and a novel product and method for identifying compounds capable of regulating inflammation. The present invention includes a method to regulate hematopoietic cell function by contacting a cell with a regulatory reagent capable of altering the activity of a molecule including PTP1C, PTP1D, ITIM-p160 and ITIM-p70. The present invention also relates regulatory reagents capable of regulating the activity of PTP1C, PTP1D, ITIMp160 and ITIM-p70, including nucleic acid molecules having sequences that encode such reagents and antibodies raised against such reagents. The present invention also includes a therapeutic composition comprising such reagents and their use to protect animals from inflammation.
Patent CA-2248585-A1 (CA)
Inventor: DULL LAWRENCE CLIFFORD
IPC: A01N25/34
Filed: 1997-04-08
Abstract: The present invention relates to a bag packaging system composed of a bag sealable to contain a liquid, in which the bag is composed of a continuous outer water soluble film (12) and an inner continuous protective film layer (14) that allows storage therein of a liquid that would chemically or physically react with the water soluble film but is prevented from doing so by the presence of the continuous protective film layer on the inner portion of the bag.
Patent CA-2248761-A1 (CA)
Title: Application to fabric of heat-activated transfers
Inventor: HARE DONALD S
IPC: D06Q1/12
Filed: 1997-03-13
Abstract: The present invention relates to a method for applying an image to a fabric, which comprises the steps of (i) hand ironing an imaged copier or printer transfer material having a support sheet and a transfer coating to a receptor element having valleys on the surface of the receptor element, (ii) peeling away the support sheet to obtain an imaged receptor element, (iii) placing a tack-free overlay sheet over the imaged receptor element, and (iv) pressing the overlay sheet by hand ironing to drive the coating into the valleys of the receptor element.
Patent CA-2249037-A1 (CA)
Title: Novel compounds
Inventor: BROWN ANTHONY M
IPC: A61K48/00
Filed: 1998-10-28
Abstract: SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Patent CA-2249375-A1 (CA)
Title: Propofol microdroplet formulations
Inventor: HAYNES DUNCAN H
IPC: A61K31/05
Filed: 1997-03-17
Abstract: Formulations of phospholipid-coated microdroplets of propofol devoid of fats and triglycerides provide chronic sedation over extended periods of time without fat overload. Being free of nutrients that support bacterial growth, these microdroplet formulations are bacteriostatic and bactericidal (e.g. self-sterilizing) and thus have extended shelf life.
Patent CA-2250268-A1 (CA)
Title: Extracellular/epidermal growth factor hcaba58x
Inventor: OLSEN HENRIK S
IPC: C12Q1/68
Filed: 1996-04-10
Abstract: The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of cell growth and differentiation, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, treating Marfan syndrome and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and diabetes. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
Patent CA-2255046-A1 (CA)
Title: Ignition device
Inventor: SUZUKI TETSUSI
IPC: H01T13/46
Filed: 1997-05-16
Abstract: In an internal combustion engine, an engine control device 40 judges based on a cooling eater temperature of an engine in what state the engine is. When judged that the engine is in a cold state, the engine control device 40 produces an ignition signal to feed it to an igniter 6b so as to spark spark plugs 7 which are individually placed in cylinders at an exhaust stroke or expansion stroke.
Patent CA-2256249-A1 (CA)
Inventor: HUIN DIDIER
IPC: C22B9/04
Filed: 1998-12-17
Abstract: A metallurgical reactor for the treatment under reduced pressure of a liquid metal (1) contained in a ladle (2) incorporates a tank (25) connected to a gas blowing installation (30) and two tubular plungers (26, 27) of which the upper ends emerge in some orifices (35, 36) cut in the bottom (28) of the tank (25) and the lower ends may be immersed in the liquid metal (1). One of the plungers (26), the ascending plunger, incorporates some means (29) for blowing the gas into its inner space to create a circulation of the liquid metal (1) between the ladle (2) and the tank (25) during treatment. It also incorporates an enclosure (17) fitted with a means (20) for blowing gas into its inner space to create in the enclosure (17) a pressure greater than atmospheric pressure and in which the ladle (2) is placed, the upper edge (23) of the enclosure (17) being provided with some means of support in a sealed manner the bottom (28) of the tank (25) during treatment and some means for lifting the ladle (2) in the direction of the tank (25) during treatment.
Patent CA-2256351-A1 (CA)
Title: Derives de pyrrolo[2,3-b]pyridine utiles en tant que ligands radiomarques du recepteur d4
Inventor: POLLAK ALFRED
IPC: C07B59/00
Filed: 1997-05-20
Abstract: Cette invention se rapporte à des composés radiomarqués et aux précurseurs de ces composés qui servent à imager les récepteurs D4 in vivo et sont représentés par la formule (I) dans laquelle R est sélectionné parmi un groupe iodo, un tri(alkyle inférieur)étain et un iodure marqué par radio-isotope et R?1¿ est sélectionné parmi H et un groupe alcoxycarbonyle, à condition que R ne soit pas un groupe iodo lorsque R?1¿ est H. Ces composés pharmaceutiques radiomarqués s'avèrent particulièrement utiles pour produire une image de la localisation du récepteur D4 dans le cerveau humain et ils peuvent par conséquent aider à diagnostiquer la schizophrénie ou d'autres troubles dans lesquels le récepteur D4 est impliqué.
Patent CA-2257025-A1 (CA)
Title: Portable radio information terminal apparatus, display screen operating method, recording medium, and microcomputer apparatus
Inventor: FURUYA MAMI
IPC: H04W88/02
Filed: 1998-12-21
Abstract: A portable radio information terminal is provided with an unprocessed-signal detecting circuit for detecting unprocessed upward or downward scroll command signals generated by a rotary input device, a screen moving-down circuit for moving down a displayed screen by as many lines as unprocessed downward scroll command signals detected by the unprocessed-signal detecting circuit, a screen moving-up circuit for moving up a displayed screen by as many lines as unprocessed upward scroll command signals detected by the unprocessed-signal detecting circuit and a display control circuit for counting the number of unprocessed downward or upward scroll command signals detected by the unprocessed-signal detecting circuit and for driving the screen moving- down circuit in the case of unprocessed downward scroll command signals or the screen moving-up circuit in the case of unprocessed upward scroll command signals.
Patent CA-2257868-A1 (CA)
Title: Modular link conveyor with interdigitating grid
Inventor: LAYNE JAMES L
IPC: B65G17/08
Filed: 1997-04-28
Abstract: A modular link conveyor including a plurality of modular link assemblies (10) made up of links (11) of an improved design assembled to create a closely interdigitating conveying surface is disclosed. The improved links (11) eliminate undesirable gaps or openings in the conveying surface. Particularly, the improved links include a forwardly extending tongue (21), projecting from the leading apex (13) of the link, which occupies an open space between the trailing apexes (16) of the legs (15) of the next forward link, thus minimizing the tendency of foreign objects from falling into the open space. The topside (23) of the tongue (21) is tapered downward so as to lift free any objects present in the open spaces primarily while the conveyor is maneuvering through a turn. A forwardly projecting finger (29), positioned between adjoining links (11), is also provided for filling a void between the adjoining links.
Patent CA-2257897-A1 (CA)
Inventor: PATON BORIS EU
IPC: C25C3/08
Filed: 1997-06-18
Abstract: A cathode construction for an electrolytic cell includes at least one carbonaceous block (30) and a plurality of electrical contact plugs (38) mounted in electrical contact with the carbonaceous block. The cathode construction also includes at least one collector plate (34, 35) in electrical contact with the electrical contact plugs. The electrical contact plugs (38) may be distributed to obtain a desired electrical field in the electrolytic cell.
Patent CA-2259523-A1 (CA)
Title: Electrochemical solid phase synthesis of polymers
Inventor: MONTGOMERY DONALD D
IPC: C25B3/29
Filed: 1997-07-03
Abstract: A solid synthesis method for the preparation of diverse sequences of separate polymers or nucleic acid sequences using electrochemical placement of monomers or nucleic acids at a specific location on a substrate containing at least one electrode (1-5) that is preferably in contact with a buffering or scavenging solution to prevent chemical crosstalk between electrodes (1-5) due to diffusion of electrochemically generated reagents.