Patent SG-11201810618Q-A (SG)
Title: Depot formulations
Inventor: TAMRAZ WILMA
IPC: A61P27/02
Filed: 2017-06-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) WIPO I PCT mu °million °nolo olooloo mo mo Imo oimIE (10) International Publication Number WO 2018/005777 Al Re ma in ing Ra t io o f S iro limus ( %) C401 )(• • C404 • C403 C402 • • •E• • C406 • • •A• • C405 • • <9.• 0407 C407 30 60 90 120 150 180 Days (51) International Patent Classification: A61K 31/436 (2006.01) A61P 27/02 (2006.01) (21) International Application Number: PCT/US2017/039968 (22) International Filing Date: 29 June 2017 (29.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/356,613 30 June 2016 (30.06.2016) US 62/440,658 30 December 2016 (30.12.2016) US (71) Applicants: DURECT CORPORATION [US/US]; 10260 Bubb Road, Cupertino, California 95014-4166 (US). SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osa- ka-shi, Osaka 533-8651 (JP). (72) Inventors: TAMRAZ, Wilma; 7002 Noonwood Ct., San Jose, California 95120 (US). SU, Huey-Ching Lin; 1138 Strada Almaden, San Jose, California 95120 (US). LIN, WeiQi; 590 California Way, Emerald Hills, California 94062 (US). YAMADA, Kazuhito; c/o Santen Pharmaceu- tical Co., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara 6300101 (JP). MATSUMOTO, Naoki; c/o Santen Phar- maceutical Co., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara 6300101 (JP). MUDUMBA, Sreenivasu; c/o Santen INC., 2100 Powell Street, Suite 1600, Emeryville, Califor- nia 94608 (US). OKABE, Komei; c/o Santen Pharmaceu- tical Co., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara 6300101 (JP). (74) Agent: MUELLER, Robert W. et al.; Greenblum & Bern- stein, P.L.C., 1950 Roland Clarke Place, Reston, Virginia 20191 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: DEPOT FORMULATIONS 100 N (57) : Pharmaceutical compositions comprising an active pharmaceutical ingredient, a high viscosity liquid carrier material, a © hydrophobic solvent, and a hydrophilic solvent are disclosed. Also disclosed are methods of manufacturing and using the compositions. C The compositions are suitable for use, e.g., as depot formulations. [Continued on next page] WO 2018/005777 Al MIDEDIMOMOIDEIREEMOMIIMINEMEMOVOIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))