baber/WOPTO huggingface dataset:
Patent ES-2304140-T3 (ES)
Title: Formas cristalinas de sodio de fluvastatina.
Inventor: VAN DER SCHAAF PAUL ADRIAAN
IPC: A61K31/404
Filed: 2002-07-25
Granted: 2008-09-16
Abstract: Un polimorfo cristalino de hidrato de sal monosódica del ácido (ñ)-7-(3-(4-fluorofenil)-1-(1-metiletil)-1H-indol-2-il)-3,5-dihidroxi-6-heptenoico que exhibe un patrón de difracción de polvo de rayos X característico con picos característicos expresados en d-valores (Å): 23,8 (vs), 11,8 (w), 7,8 (vs), 7,6 (vw), 7,4 (vw), 6,1 (vw), 5,90 (w), 5,00 (vw), 4,88 (w), 4,73 (m), 4,56 (w), 4,40 (vw), 4,12 (vw), 4,03 (vw), 3,96 (vw), 3,50 (vw), 3,36 (vw), 2,93 (vw), en donde (vs) = intensidad muy fuerte; (s) = intensidad fuerte, (m) = intensidad media; (w) = intensidad débil; y (vw) = intensidad muy débil.
Patent ES-2307837-T3 (ES)
Inventor: VOLK HARALD DR
IPC: C11D17/00
Filed: 2003-02-24
Granted: 2008-12-01
Abstract: A perfumed single- or multi-phase detergent body is obtained by contacting a shaped body based on surfactant(s), builder(s) and conventional additives with one or more perfumes or an active mixture containing at least20 wt.% perfume based on the shaped body wt.  An Independent claim is also included for the use of a mixture containing polyalkyleneglycol(s) and perfume as an adhesive in the detergent.
Patent ES-2289200-T3 (ES)
Inventor: GLENN GREGORY M
IPC: A61K39/106
Filed: 1999-02-25
Granted: 2008-02-01
Abstract: Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.
Patent ES-2260559-T3 (ES)
Title: Amasadora para pastas alimenticias, particularmente para productos de panaderia.
Inventor: DROCCO DAVIDE
IPC: B01F29/83
Filed: 2003-10-22
Granted: 2006-11-01
Abstract: Amasadora que comprende: - un depósito (7) substancialmente cilíndrico; y - un par de herramientas amasadoras (13) que giran en el interior del depósito (7), con sentidos concordantes de rotación, alrededor de dos ejes (14) paralelos al eje (6) del depósito, substancialmente tangenciales tanto el uno con respecto al otro, como con respecto a la pared circunferencial del depósito (7), en la que - cada herramienta (13) comprende un brazo (13a); - cada brazo (13a) se extiende en la periferia, y desde un extremo hasta el otro de un cilindro teórico (XIII) dotado de un eje que coincide con el respectivo eje de rotación (14) de dicho brazo (13a), de tal manera que dicho brazo (13a) describe un movimiento giratorio alrededor del respectivo eje de rotación (14); - cada uno de los brazos (13a), por lo menos en una parte de su longitud, está inclinado con respecto a una generatriz de línea recta de dicho cilindro teórico (XIII) paralelo a dicho eje de rotación (14) del brazo (13a); - los extremos opuestos de los dos brazos (13a) están escalonados uno con respecto al otro, vistos en el sentido del eje de rotación, a un ángulo (A) inferior a 180º alrededor de dicho eje de rotación (14); - están previstos unos medios para hacer que dichos brazos (13a) realicen unos movimientos giratorios alrededor del respectivo eje de rotación (14), que están sincronizados entre sí, de tal manera que los brazos (13a) pasan simultáneamente en la zona de tangencia de los respectivos cilindros teóricos (XIII), interseccionándose con unos sentidos de movimiento opuestos debido a la rotación concordante de las dos herramientas, caracterizada porque - el depósito (7) es un depósito giratorio, - los ejes de rotación (14) de las herramientas amasadoras (13) son ejes fijos, y - cada una de las herramientas amasadoras (13) comprende un único brazo (13a), presentando cada brazo (13a) un extremo libre.
Patent ES-2259128-T3 (ES)
Inventor: SCHOLZ ULRICH DR
IPC: C07C17/266
Filed: 2003-12-30
Granted: 2006-09-16
Abstract: New copper complexes (I) have organic phosphine, phosphonite or phosphite or corresponding amino or thio-substituted ligands.  New copper complexes of formula (I) have organic phosphine, phosphonite or phosphite or corresponding amino or thio compound substituted ligands; Het1, Het2, Het3  = absent, O or NR1;  R1  = 1-8 C alkyl, 5-18 C aryl or 6-19 C arylalkyl;  B1, B2  = R or together a divalent group with a total of 2-40 C;  B3  = R or an n-valent group with a total of 2-40 C;  R  = as R1;  X  = halide, 1-6 C (halo)alkyl carboxylate, 1-8 C haloalkyl sulfonate, 5-18 C arylsulfonate, CN, optionally fluorinated acetylacetonate, nitrate, oxinate, phosphate, carbonate, hexafluorophosphate, tetraphenylborate, tetrakis(pentafluorophenyl)borate or tetrafluoroborate;  p  = 0, 1 or 2;  n  = 1, 2 or 3;  m  = 1, 2, 3, 4, 5 or 6. Independent claims are also included for the following:  (1)  catalysts containing the Cu complexes; (2) preparation of substituted aromatic compounds of formula (IV) by reacting compounds of formulae (V) and (VI) in the presence of base and catalysts containing the Cu complexes: Ar-(F-R2)n (IV);  Ar-Z (V); H-F-R2 (VI);  n = 1, 2 or 3;  Ar = an (un)substituted aromatic group;  F = O, S, NR3, NR3CO or ethyndiyl;  R3 = H, 1-12 C alkyl, 5-18 C aryl or 6-19 C arylalkyl;  R2 = Ar, 1-12 C (halo)alkyl, 1-12 C alkenyl or 6-19 C arylalkyl;  Z = Cl, Br, I, a diazonium salt or a sulfonate.
Patent ES-2321495-T3 (ES)
Inventor: MATEU JUAN R
IPC: A61K8/04
Filed: 2003-06-13
Granted: 2009-06-08
Abstract: Wax-free cosmetic gel product in the form of a transparent or translucent stick comprises 5-85 wt.% oil, hydrogenated hydrocarbon, alkene or mono-, di- or tri-ester, 0.1-15 wt.% 12-hydroxystearic acid, polyethylene (molecular weight 400-2500) or glyceryl behenate, 0.5-5 wt.% surfactant, and additives, carriers and/or active ingredients.
Patent ES-2316695-T3 (ES)
Title: Montaje de asistencia de conexion para conector electrico.
Inventor: MARTIN GALEN MONROE
IPC: H01R13/639
Filed: 2003-01-23
Granted: 2009-04-16
Abstract: Un conector eléctrico ,que comprende: alojamientos primero y segundo (20, 25), configurados para recibir contactos eléctricos, y con extremos delanteros configurados para poder acoplarse entre sí a fin de unir los contactos correspondientes, siendo dichos alojamientos primero y segundo amovibles entre las posiciones inicial y final, en las cuales dichos alojamientos primero y segundo se ensamblan, respectivamente, de manera parcial y total, y un miembro (15) de palanca que engrana dichos alojamientos primero y segundo, y que mueve dichos alojamientos primero y segundo entre dichas posiciones inicial y final, según dicho miembro de palanca se hace girar a lo largo de un intervalo de movimiento, incluyendo dicho miembro de palanca un brazo (185) de leva con un primer elemento (190) de retención proporcionado sobre al menos un lado de dicho brazo de leva, para engranar dicho primer alojamiento, y un segundo elemento (220, 225, 230) de retención para engranar dicho segundo alojamiento; caracterizado por: un bloque (82) de retención de palanca proporcionado dentro de una región interior de dicho primer alojamiento (20) y con una cámara pivote (171) que retiene dicho primer elemento (190) de retención, permitiendo a la vez la rotación de dicho primer elemento (190) de retención dentro de dicha cámara pivote (171), según dicho miembro (15) de palanca gira a lo largo de dicho intervalo de movimiento, y un poste (267) de acoplamiento montado dentro de una región interior de dicho segundo alojamiento (25), incluyendo un elemento (315) de retención de leva configurado para engranar y sujetar dicho segundo elemento (220, 225, 230) de retención, según dicho miembro (15) de palanca está girando a través de dicho intervalo de movimiento, en el cual dicho segundo elemento (220, 225, 230) de retención constituye una muesca formada en una superficie periférica de dicho brazo (185) de leva y dicho elemento (315) de retención de leva constituye un diente de leva.
Patent ES-2244909-T3 (ES)
Inventor: BENITO NAVAZO JUAN MANUEL
IPC: B65D71/00
Filed: 2003-10-28
Granted: 2005-12-16
Abstract: The invention relates to a palletisation device which facilitates direct palletisation of stacked elongated prismatic bodies and which consists in an elongated strong body (1) which, with respect to its entire length and oppositely parallel, has two flat bearing surfaces (5) and, between said flat surfaces (5), has at least two through holes (4) in transverse direction and a passage (9) in longitudinal direction. Said through holes (4) are distanced such as to be compatible with the width of the fork of a fork lift truck. The strong body (1) is constituted by two laths (2) superposed in parallel and connected by their facing faces (8) by means of spacers (3) of which two are at the ends and a third is central. The device according to the invention may also comprise an auxiliary member for joint palletisation of two series of stacked bodies. <IMAGE>
Patent ES-2297111-T3 (ES)
Inventor: VEIGA ABREU ROCHA ALEXANDRE MI
IPC: A61P9/08
Filed: 2003-09-18
Granted: 2008-05-01
Abstract: The presente invention concerns a stable diltiazem hydrochloride pharmaceutical composition for cutaneous application, comprising in its composition only oily excipients and a content of deacethyldiltiazem of less than 0.3% (w/w) in the final product. <??>The invention also concerns a process for the preparation of the said composition. <IMAGE>
Patent ES-2272933-T3 (ES)
Inventor: CARDINALI ADRIO
IPC: A47G1/16
Filed: 2003-07-31
Granted: 2007-05-01
Abstract: The present invention refers to an adjustable picture hook composed of two plates (1;2) matched together with the possibility of vertical sliding, with one plate (1) provided with means (1a) for fixing to the picture and the other plate (2) provided with hole or slot (2a) for fixing to support means on the wall. According to the different constructive embodiments, the hook can be adjusted by acting on the sliding plates (1;2) directly or with the aid of suitable adjustment means that determine the mutual sliding of the plates. <IMAGE>
Patent ES-2362260-T3 (ES)
Inventor: SILVA MARCIO
IPC: C07H17/04
Filed: 2003-03-25
Granted: 2011-06-30
Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6, 6'-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
Patent ES-2270030-T3 (ES)
Inventor: DEPOOT KAREL JOZEF MARIA
IPC: C11D17/08
Filed: 2003-05-15
Granted: 2007-04-01
Abstract: The present invention relates to a liquid softening through the wash laundry detergent composition comprising: (a) at least 0.5% by weight of the composition, of a fabric softening silicone; and (b) a fatty acid; and (c) a surfactant system, the surfactant system comprising: (i) at least 75% by weight of the surfactant system, of a non-alkoxylated anionic surfactant; and (ii) less than 25% by weight of the surfactant system, of an alkoxylated surfactant; and (d) one or more laundry detergent adjunct ingredients.
Patent ES-2276065-T3 (ES)
Inventor: HORRES ROLAND
IPC: A61K31/436
Filed: 2003-04-15
Granted: 2007-06-16
Abstract: The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
Patent ES-2289314-T3 (ES)
Inventor: DESSEN ERIK
IPC: B01J8/00
Filed: 2003-09-24
Granted: 2008-02-01
Abstract: This invention relates to a method for filling particulate material in vertical tubes (1) where the velocity of fall of the material (4) is reduced by having it glide down a rotating spiral duct (2) or by gliding down a rotating inner tube (5) with openings above the bottom (6) through which the material can fall out. The inner tube (5) is filled with the particulate material (4). After the material has fallen out of the spiral duct (2) or the inner tube (5), it can fall towards the tube's (1) wall during the drop onto the top layer of filled material.
Patent ES-2422881-T3 (ES)
Title: Uso de eritropoyetina para la regeneración de tejido in vivo
Inventor: BADER AUGUSTINUS
IPC: A61K35/28
Filed: 2003-06-20
Granted: 2013-09-16
Abstract: Uso de eritropoyetina (EPO) para la preparación de un medicamento para el tratamiento tópico de la piel durantela cicatrización tras la rugosificación del sustrato en el contexto de un desbridamiento y aplicación de EPO, en el quela EPO se integra en un coágulo de sangre mediante polimerización desencadenada por cloruro de calcio y se liberaa partir del mismo lentamente de forma local en la herida.
Patent ES-2335659-T3 (ES)
Title: Pirimidopirimidonas como inhibidores de quinasas.
Inventor: CONNOLLY CLEO J CHIVIKAS
IPC: A61P25/00
Filed: 2003-07-21
Granted: 2010-03-31
Abstract: Un compuesto de fórmula: **(Ver fórmula)** en la que: A es O; B y D son N, y C es CH2; R1 se selecciona del grupo de alquilo C1-C6 de cadena lineal o ramificada, opcionalmente sustituido con -COOH, o a) un anillo fenilo, bencilo o cicloalquilo C3-C8, o un anillo -CH2-(cicloalquilo C3-C8), estando los anillos de los grupos fenilo, bencilo o cicloalquilo opcionalmente sustituidos con 1 o 2 grupos COOH o CH2-COOH; o b) un resto piperidina o piperazina seleccionado del grupo de: **(Ver fórmula)** estando los anillos de los restos de piperidina o piperazina opcionalmente sustituidos con 1 ó 2 grupos COOH o -CH2-COOH; o c) un resto tetrahidropirano o morfolina de fórmulas: **(Ver fórmula)** R2 es H, Cl o F; R3 es H, Cl o F, con la condición de que al menos uno de R2 o R3 es F; R4 es H, OH, -OCH3, o -OCH2CH3, con la condición de que si R4 es H, R2 y R3 no son H; R5 es -OCH3, o -OCH2CH3; R6 se selecciona del grupo de H, -(alquil C1-C5)-NH2, -(alquil C1-C5)-NH-(alquil C1-C3)-R11, -(alquil C1-C5)-N-(alquil C1-C3-R11)2, -O-(alquil C1-C5)-NH2, -O-(alquil C1-C5)-NH-(alquil C1-C3)-R11, -O-(alquil C1-C5)-N-(alquil C1-C3-R11)2, -CH(CH2OH)2, -(alquil C1-C3)-(CH2OH), -(alquil C1-C3)-O-(alquil C1-C3)-R11, -(alquil C1-C3)-O-(alquil C1-C3)-NH2, -(alquil C1-C3)-O-(alquil C1-C3)-NH-(alquil C1-C3)-R11, -(alquil C1-C3)-O-(alquil C1-C3)-N(alquil C1-C3-R11)2, fenilo sustituido con 1 ó 2 grupos seleccionados de NH2, -N(alquilo C1-C3), -N(alquilo C1-C3)2, CN o -(alquil C1-C3)-tetrazol, o alquilo C1-C6, **(Ver fórmula)** o **(Ver fórmula)** estando cada una de las cadenas de alquilo de cualquier grupo en esta definición de R4 opcionalmente sustituida con de 1 a 4 grupos OH; R7, en cada caso se selecciona independientemente de H, -NH2, NH(alquilo C1-C3</sub >), N(alquilo C1-C3)2, o alquilo C1-C3; R8 es H, OH o alquilo C1-C3; R9 es H, OH, -NH2, NH(alquilo C1-C3), o N(alquilo C1-C3)2; R11 es H, CN, OH, NH2, F, o CF3; o su forma de éster o sal farmacéuticamente aceptable.
Patent ES-2273050-T3 (ES)
Inventor: JOSEPH STEPHEN C P
IPC: B05B7/24
Filed: 2003-10-13
Granted: 2007-05-01
Abstract: A spray gun 101 has a spray head 150 connected to a body 102 of the spray gun 101 and a reservoir 156 connected to the spray head 150 for supplying liquid to a spray nozzle 153 of the spray head 150. The spray head 150 is arranged so that liquid from the reservoir 156 is delivered to the spray nozzle 153 without passing through the spray gun body 102 in response to actuation of the spray gun 101 via a trigger 105. The spray head 150 is releasably secured and can be detached from the spray gun body 102 and thrown away after use. The reservoir 156 is mounted on the spray head 150 and can be removed and thrown away with the spray head 150 after use.
Patent ES-2372599-T3 (ES)
Inventor: SOUBRIER FABIENNE
IPC: C12N15/74
Filed: 2003-10-14
Granted: 2012-01-24
Abstract: A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
Patent ES-2274308-T3 (ES)
Title: Composicion de perfume.
Inventor: RANADE VIDYADHAR S
IPC: C11D3/50
Filed: 2003-07-24
Granted: 2007-05-16
Abstract: Un procedimiento para preparar copos de película de perfume que comprenden inclusiones de partículas de perfume en el que dichas partículas comprenden material de vehículo de partícula y perfume por lo que dicho procedimiento comprende los pasos de: a) formar una película de material reactivo en agua que contiene inclusiones de partículas de perfume; b) solidificar dicha película por enfriamiento y/o secado y c) fraccionar la película solidificada en copos de película de perfume que comprenden inclusiones de partículas de perfume, en el que el procedimiento para formar la película no es un procedimiento de extrusión.
Patent ES-2277146-T3 (ES)
Title: Elemento de construccion, y metodo para fabricarlo.
Inventor: HOUBEN EWALD
IPC: E04B5/38
Filed: 2003-09-15
Granted: 2007-07-01
Abstract: Elemento de construcción para formar una losa (2) de hormigón armado, que consiste en la combinación de al menos una capa de hormigón endurecido (3), al menos una serie de elementos de refuerzo (4), y elementos (5) que se extienden al menos parcialmente desde la capa de hormigón (3) y definen cavidades (6), de forma que estos elementos (5) están diseñados para ser cubiertos con hormigón (7) en una etapa posterior, caracterizado porque los elementos (5) mencionados arriba están anclados al elemento de construcción (1) por medio de piezas de bloqueo (15), provistas sobre los elementos (5) que definen cavidades, estando las mencionadas piezas de bloqueo (15) provistas sobre una parte de los elementos (5) que definen cavidades, con la se apoyan en la capa de hormigón (3), de forma que están, o no, bloqueados en el refuerzo que ha sido embutido en la mencionada capa de hormigón (3), por medio de un anclaje que es sólido, de modo que los mencionados elementos (5) al menos permanecerán anclados impidiendo su flotación, cuando es vertido hormigón líquido u hormigón colado (7) sobre estos.
Patent ES-2271729-T3 (ES)
Inventor: LEBOISNE CEDRIC
IPC: F16F15/03
Filed: 2004-04-06
Granted: 2007-04-16
Abstract: The servomotor has a shock absorbing unit (68) absorbing relative movement and oscillation between a control shaft (33) and a pneumatic piston (8). The shock absorbing unit comprises an annular joint (72) having a high friction coefficient and mounted in a circular groove (70). The groove is practiced on an exterior surface of a cylindrical part (58) of a plunger (32).
Patent ES-2392823-T3 (ES)
Title: Uso de compuestos de vitamina D
Inventor: SIMOES-NUNES CARLOS
IPC: A61P19/08
Filed: 2004-08-19
Granted: 2012-12-14
Abstract: El uso de 25-hidroxi-vitamina D3 en combinación con vitamina D3 en la fabricación de un pienso ocomposición veterinaria para mejora de la fuerza ósea en los cerdos
Patent ES-2262075-T3 (ES)
Inventor: PUJOL HERVE
IPC: B60T11/16
Filed: 2004-09-15
Granted: 2006-11-16
Abstract: The master cylinder comprises body(2) with bore(3) containing piston(s)(8,10), and passage(36) with valve(18) linking feed chamber to working chamber connected to brakes. In valve's rest state the distance between first end(44) of slot furthest from valve and first side(46) of thrust element further from base(5) of cylinder body is less than distance between first end(34) of piston and base(5). The master cylinder consists of a body (2) with a bore (3) containing at least one piston (8, 10) having a lengthwise slot (30) acting as a hydraulic fluid feed chamber, and a passage (36) with a valve (18) linking the feed chamber to a working chamber connected to the brakes. In the valve's rest state its shutter (22) presses against a thrust element (42) fixed across the body of the cylinder in the lengthwise slot, and the distance between a first end (44) of the slot furthest from the valve and the first side (46) of the thrust element further from the base (5) of the cylinder body is smaller than the distance between the first end (34) of the piston and the base (5). The thrust element is in the form of a transverse pin, and the slot ends in a curved section of similar diameter to the pin to ensure an event distribution of stresses applied by the pin to the piston.
Patent ES-2349364-T3 (ES)
Inventor: AYALON ARI
IPC: C07D207/34
Filed: 2000-11-16
Granted: 2010-12-30
Abstract: The present invention relates to pharmaceutical compositions and dosage forms containing atorvastatin calcium Form V.
Patent ES-2293153-T3 (ES)
Inventor: VOIT JENNY
IPC: A61F5/01
Filed: 2004-12-02
Granted: 2008-03-16
Abstract: The present invention provides a method and a device for producing an orthosis model for a patient. The method comprises the input of patients' data (104), the determination (106) of a curvature type of the patient's spine to be treated from a predefined number of curvature types in dependence on the patient's data, and the selection (110) of at least one orthosis model from a predefined number of models of orthoses in dependence on the specific curvature type.The device comprises a data input device (6) being designed for inputting patients' data, a data base (12) containing a number of curvature types and a number of orthoses models, a curvature determination device (8) designed to determine a curvature type from the data base in dependence on the patients' data, and an orthosis model selection device (10) designed to select at least one orthosis model from the data base (12) in dependence on the determined curvature type.
Patent ES-2355622-T3 (ES)
Inventor: VOLL PARKER J
IPC: G06F1/26
Filed: 2004-09-24
Granted: 2011-03-29
Abstract: A distance extender (100, 200) for increasing a distance between a first device (145) and a second device (150) in electrical communication with the first device includes an electrical cable (130, 230) electrically coupled between the first device and the second device, a first subsystem (110, 210) electrically coupled to the first end of the electrical cable, and a second subsystem (120, 220) electrically coupled to the second end of the electrical cable. The electrical cable includes a first end (131, 231), a second end (132, 232), and a plurality of wires extending between the first end and the second end. The plurality of wires includes a first wire, the first device generates a data signal and provides an electrical power signal, and the data signal and the electrical power signal are simultaneously transmitted between the first device and the second device over the first wire.
Patent ES-2347431-T3 (ES)
Inventor: PETRINI LEONIDA
IPC: A23L33/155
Filed: 2004-01-29
Granted: 2010-10-29
Abstract: This invention concerns an edible oil, better if it is olive oil, which favours the calcium assimilation from food, due to the fact that vitamin D3 and vitamin K1 have been added.