baber/WOPTO huggingface dataset:
Patent CA-3101198-A1 (CA)
Title: Biomarkers and therapeutics for endocrine therapy resistance
Inventor: LISANTI MICHAEL P
IPC: A61K31/55
Filed: 2019-05-30
Abstract: Cancer cells can develop resistance to endocrine therapies, such as Tamoxifen, through acquisition of the Y537S mutation. Cells transfected with the Y537S mutation showed significant increases in mitochondrial mass and membrane potential, consistent with an increase in mitochondrial biogenesis. Certain biomarkers are identified that have prognostic value of endocrine therapy resistance. The mechanism resulting in this resistance, however, leaves these treatment-resistant cells vulnerable to therapeutics that inhibit mitochondrial biogenesis. Numerous mitochondrial biogenesis inhibitors are disclosed, as well as methods for reducing or eliminating endocrine treatment resistance, improving the effectiveness of an endocrine therapy, and for treating cancer.
Patent CA-3101459-A1 (CA)
Inventor: ROUX GUILHEM
IPC: H01M8/248
Filed: 2018-10-23
Abstract: The main subject matter of the invention is an assembly (80) comprising a SOEC/SOFC-type solid oxide stack (20), and a clamping system (60) for the stack (20), said clamping system comprising at least two clamping rods (55) that can be used to assemble upper (45) and lower clamping plates (46). The assembly (80) further comprises a heat exchange system (40) formed at least in part by at least two hollow clamping rods (55) of the clamping system (60), through which a fluid to be superheated or preheated flows.
Patent CA-3106785-A1 (CA)
Title: Tool holder and packaging therefor
Inventor: WETRICH BRIAN S
IPC: B65D5/42
Filed: 2021-01-22
Abstract: Abstract A tool holder for firmly holding a wide range of sizes and shapes of tool handles includes a holder handle, a cage assembly, a clamp, a locking coupling, and a threaded actuator. The cage assembly includes a pair of axially spaced apart supports having axially aligned through openings sized for receiving tool handles of different sizes and shapes. The clamp is transversely movable between the supports in opposite directions for releasably clamping the tool handle against the supports. The locking coupling is interposed between the holder handle and the cage assembly for selectively adjusting the angular orientation of the cage assembly relative to the holder handle. The threaded actuator is operable to lock or unlock the locking coupling for permitting or restricting adjustment of the angular orientation of the cage assembly relative to the holder handle. Date Recue/Date Received 2021-01-22
Patent CA-3109949-A1 (CA)
Inventor: FARMER SEAN
IPC: E21B37/06
Filed: 2019-08-20
Abstract: The subject invention provides a three-part method for increasing the amount of oil recovered from an oil well, the method comprising (1) paraffin removal; (2) gas release; and (3) plugging. The combination of parts provides for enhanced oil recovery over an extended period of time, for example two weeks or longer. In preferred embodiments, the subject invention utilizes microorganisms and/or their growth by-products, as well as other environmentally-friendly compounds, to enhance oil recovery by removing paraffin deposits from a well and providing controlled production of carbon dioxide in the well.
Patent CA-3112765-A1 (CA)
Title: Deuterium-enriched pirfenidone and methods of use thereof
Inventor: ELENKO ERIC
IPC: A61K45/06
Filed: 2019-09-16
Abstract: Disclosed herein are deuterium-enriched N-Aryl pyridinone compounds, optionally in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising the same, methods of preparation thereof, and methods of use thereof. Such compounds and compositions are useful, for example, in treating diseases, disorders, or conditions such as edema.
Patent CA-3115629-A1 (CA)
Inventor: MOLONEY JEREMY
IPC: E21B41/02
Filed: 2019-10-04
Abstract: Disclosed are sulfide-based compounds which are a product of a Michael addition reaction between a sulfur-containing donor group and an unsaturated hydrocarbon moiety. The sulfide-based compounds may be used in compositions and methods for inhibiting corrosion.
Patent CA-3118366-A1 (CA)
Inventor: KNUDSEN MARTIN KAHR
IPC: H01H3/02
Filed: 2019-11-08
Abstract: Emergency stop for a linear actuator system, which comprises a housing (13) and an activation button (12) adapted for activating a circuit breaker and where the activation button (12) has a neutral position and an emergency position. The emergency stop further comprises a spring (19) for spring-loading the activation button (12) for retaining the activation button (12) in the neutral position, a latching mechanism adapted for retaining the activation button (12) in the emergency position once it has entered this position, and a release mechanism adapted to unlatch the latching mechanism. The spring-loaded activation button (12) is pivotally connected to the housing (13) and arranged to pivot between the neutral position and the emergency position. The spring- loaded activation button (12) comprises an arm (26,27) having one end attached to the underside (24) of the spring-loaded activation button (12). The housing 13 comprises a wall piece (35,36) adapted for engaging a free end of the arm (26,27). The latching mechanism comprises a protruding part (61,62) on the arm (26,27) and a receiving part (39,40) on the wall piece (35,36), said protruding part (61,62) and said receiving part (39,40) being unlatched when the activation button (12) is in the neutral position and latched when the activation button (12) is in the emergency position. The release mechanism comprises a reactivation button (14,15) movable between a first and second position, said reactivation button (14,15) unlatches the latching mechanism by disengaging the protruding part (61,62) from the receiving part (39,40) when the reactivation button (14,15) is moved from the first position to the second position.
Patent CA-3121839-A1 (CA)
Title: Use of urethane methacrylate compounds in reactive resin compositions
Inventor: NICKERL GEORG
IPC: C09D5/00
Filed: 2019-11-27
Abstract: The invention relates to the use of low-viscosity urethane methacrylate compounds in a reactive resin component for improving the thixotropic properties of the reactive resin component and/or the tailing behaviour of a reactive resin system comprising the reactive resin component.
Patent CA-3122768-A1 (CA)
Title: Methods and apparatus for constructing airships
Inventor: BRIN SERGEY
IPC: F16S3/08
Filed: 2018-10-11
Abstract: ABSTRACT  Systems, apparatuses, and methods for constructing an airship quickly and cost-effectively are described. In one embodiments, an airship structure may have a plurality of mainframes, each comprising interconnected pyramid structures. One of the pyramid structures may include an apex joint, four base joints, first connectors, and second connectors. The apex joint and base joints may each have slots configured for receiving connectors.  The apex joint may have four apex-to-base slots and each base joint may have a base-to-apex slot and two base-to-base slots. Each of the first connectors may connect the apex joint to one of the four base joints using one of the apex-to-base slots of the apex joint and the base-to-apex slot of that base joint. Each of the second connectors may connect two of the four base joints using one of the base-to-base slots of each of the two base joints connected by that second connector. Date Recue/Date Received 2021-06-17
Patent CA-3122986-A1 (CA)
Inventor: DENLI HUSEYIN
IPC: G01V1/30
Filed: 2019-11-15
Abstract: Un procédé et un appareil d'analyse sismique comprennent l'obtention d'un modèle géophysique initial et de données sismiques pour une région de sous-surface ; la production d'une image de sous-surface de la région de sous-surface avec les données sismiques et le modèle géophysique ; la génération d'une carte d'une ou plusieurs caractéristiques géologiques de la région de sous-surface par interprétation automatique de l'image de sous-surface ; et la mise à jour de manière itérative du modèle géophysique, de l'image de sous-surface, et de la carte des caractéristiques géologiques, par : la construction d'un modèle géophysique mis à jour sur la base du modèle géophysique d'une itération précédente contraint par une ou plusieurs caractéristiques géologiques de l'itération précédente ; la mise en image des données sismiques avec le modèle géophysique mis à jour pour produire une image de sous-surface mise à jour ; et l'interprétation automatique de l'image de sous-surface mise à jour pour générer une carte mise à jour de caractéristiques géologiques. Le procédé et l'appareil peuvent également comprendre la migration après sommation, la migration avant sommation, la migration en profondeur avant sommation, la migration à rebours, la tomographie à base de gradient et/ou des procédés d'inversion à base de gradient.
Patent CA-3124826-A1 (CA)
Inventor: MCSPADDEN KEMPER J
IPC: C11C3/00
Filed: 2014-08-26
Abstract: Il est décrit un réacteur et un procédé pour la production de biodiesel. Le réacteur comprend au moins une conduite de réaction en spirale. Les conduites sont positionnées à lintérieur dun réservoir contenant un milieu de transfert de chaleur, tel quun sel fondu, maintenu à environ 400 ºC (750 ºF). Une pompe fait circuler le milieu dans le réservoir. Une émulsion dalcool; de charge dalimentation raffinée, comprenant des glycérides et/ou des acides gras; et de préférence deau est pompée par les conduites de réaction à des températures et pressions suffisantes pour maintenir lalcool dans un état super critique. La courbure des bobines, limpulsion de la pompe et la vitesse découlement de lémulsion maintiennent lémulsion dans un état turbulent tandis quelle est dans le réacteur, assurant un mélange total de lalcool et de la charge dalimentation. Lalcool réagit avec les glycérides et les acides gras pour former le biodiesel. La réaction est rapide, efficace par rapport à lénergie entrée et les déchets produits et requière un niveau dalcool minimal.
Patent CA-3129041-A1 (CA)
Title: Chariot pour l'inspection de parametres de construction de voies ferrees
Inventor: GONZALEZ ALVAREZ CESAREO
IPC: B60M1/28
Filed: 2019-02-07
Abstract: Selon l'invention, un chariot pour l'inspection de paramètres de construction de voies ferrées comprend deux châssis, gauche et à droit, reliés de manière pliable à un corps central, chaque châssis étant pourvu d'un ensemble de roulement monté aux extrémités libres des châssis. Lesdits ensembles de roulement sont pliables par rapport aux châssis, et à partir du corps central ressort une colonne télescopique dont la section finale comporte un guidon pour manoeuvrer le chariot, et un plateau pour supporter des équipements de contrôle, tels qu'un ordinateur, ledit plateau étant pliable par rapport à la colonne télescopique et celle-ci par rapport au corps central jusqu'à rentrer en contact avec le plan supérieur des châssis, formant un ensemble compact, portable, manoeuvrable de manière simple et par un seul opérateur.
Patent CA-3130550-A1 (CA)
Title: Tone-enhancing drum shell and methods of making and using same
Inventor: PARK HYUK JAE
IPC: G10D13/02
Filed: 2019-02-15
Abstract: A drum having modified tone qualities is provided. The drum has a generally cylindrical inner shell positioned within a generally cylindrical outer shell. The inner shell has at least one sound-transmitting aperture defined therethrough so that the sound-transmitting aperture provides an unobstructed passageway for sound waves to pass through to reach the outer shell. In some aspects, an insert for modifying the tone qualities of a drum is provided. In some aspects, the outer shell has one or more inwardly extending protrusions co-located with and extending through the at least one sound transmitting aperture.
Patent CA-3130869-A1 (CA)
Title: Polyether polyol
Inventor: BONAMI LIES
IPC: C08G18/76
Filed: 2020-03-03
Abstract: The present invention relates to a process for providing a homogeneous polyether polyol composition comprising the following steps: Providing a crude polyether polyol mixture comprising polyether polyol and a Group IA or Group IIA metal ion; Neutralisation of said crude polyether polyol mixture by adding a strong acid to said mixture, resulting in a neutralised polyether polyol composition, which comprises said polyether polyol along with a salt of said Group IA or Group IIA metal ion and said strong acid; Providing said homogeneous polyether polyol composition. characterised in that said strong acid is a pentavalent organic phosphorus compound, and in that said salt is a phosphorus-containing compound based organic salt, which is soluble in said polyether polyol composition.
Patent CA-3131332-A1 (CA)
Title: Method for preparing a food solid, food solid comprising konjac glucommannan and use thereof
Inventor: SAMAIN DANIEL FRANCOIS JEAN MARIE
IPC: A23L7/109
Filed: 2020-03-13
Abstract: The invention relates to a method for preparing a food solid wherein the following mixture is produced: - a quantity of a flour comprising at least one polysaccharide, called the heteromannan, chosen from the group formed of glucomannans and galactomannans, and - a quantity of an aqueous liquid composition, wherein the heteromannan is in such a quantity that the ratio of the mass of the heteromannan in the mixture to the mass of the aqueous liquid composition in the mixture is between 5% and 35%, and in that the mixture is prepared by vigorous stirring, whereby a substantially homogenous dispersion, called the pourable dispersion, of the flour in the aqueous liquid composition is formed having a dynamic viscosity of less than 100 Pa.s, the pourable dispersion varying spontaneously to form an aqueous cohesive solid substantially devoid of a free aqueous liquid composition and having a dynamic viscosity greater than the dynamic viscosity of the pourable dispersion; and subsequently a step of maturing the aqueous cohesive solid and hardening the aqueous cohesive solid is carried out so as to form the food solid, the food solid formed being non-adhesive and non-coalescent; and wherein, since the heteromannan comprises at least one glucomannan, the heteromannan is not subjected to any treatment with an alkaline agent, in particular any treatment with calcium hydroxide (Ca(OH)<sub>2</sub>) or sodium carbonate.
Patent CA-3132769-A1 (CA)
Inventor: TIPALDO JOHN
IPC: E01F9/608
Filed: 2021-08-11
Abstract: A retractable cylindrical safety marker is provided. The retractable cylindrical safety marker includes a base, having a middle section defining an upper planar surface and two opposing edges; a first end section rotatably attached at an end to one of the opposing edges; and a second end section rotatably attached at an end to the other of the opposing edges, and a vertical riser, having a lower riser having a lower end attached to the first end section and the second end section, the lower riser having a slot extending along its interior surface in the longitudinal direction; and at least one upper riser concentrically positioned within the lower riser, the upper riser having a tab positioned on an outer surface thereof, the tab being mateable with the slot and configured to permit the tab to translate along the slot.
Patent CA-3133171-A1 (CA)
Inventor: CIACH TOMASZ
IPC: A61K51/04
Filed: 2019-03-19
Abstract: Process for preparation of polymeric nanoparticles that chelate radioactive isotopes and have their surface modified with specific molecules targeting PSMA receptor on the surface of cancer cells, with a targeting agent modified by a linker molecule attaching to free aldehyde groups present in the dextran chain. Polymeric nanoparticles that chelate radioactive isotopes synthesised according to the claimed process for use in therapy and diagnostics of prostate cancer and metastatic cancer cells as well as other affected cells for which the nanoparticles show the affinity.
Patent CA-3138352-A1 (CA)
Title: Systems and methods for wireless power transmission in a well
Inventor: JOSHI MAHENDRA L
IPC: E21B47/13
Filed: 2020-05-13
Abstract: Systems and methods for wireless power transmission in a well, wherein first and second structural members of a well completion are electrically connected to form an electrical circuit, with first and second toroidal transformers positioned around the second structural member at different axial locations. A power source coupled to the first toroidal transformer is configured to generate an output voltage which is applied to the first toroidal transformer, inducing a corresponding electrical current in the electrical circuit. This in turn induces a second voltage on the second toroidal transformer, which is provided to a downhole tool. The tool may include conditioning circuitry, which rectifies the received power and charges a battery. The downhole electric tool is then operated using the received power.
Patent CA-3139783-A1 (CA)
Inventor: PENG JIN
IPC: C07D519/00
Filed: 2020-05-08
Abstract: La présente invention concerne un composé représenté par la formule I et un racémate, un stéréoisomère, un tautomère, un marqueur isotopique, un oxyde d'azote, un solvate, un polymorphe, un métabolite, un ester, un sel pharmaceutiquement acceptable ou un promédicament de celui-ci, une composition pharmaceutique le comprenant, son procédé de préparation, et une utilisation pharmaceutique de celui-ci. Le composé inhibe USP28 et/ou USP25. La structure de la formule I est la suivante.
Patent CA-3140138-A1 (CA)
Title: Fluid conduits with selectively coated surfaces
Inventor: RIEDEL ROBERT E
IPC: F16L57/06
Filed: 2021-11-22
Abstract: A fluid conduit system (100) a first conduit section (102) having a first conduit bore (124) extending from a first end (106) of the first conduit section (102) to a second end of the first conduit section (102), the first conduit bore (124) including a first beveled surface (128) proximate the first end (106) of the first conduit section (102). The fluid system (100) also includes a second conduit section (104) coupled to the first conduit section (102) and having a second conduit bore (138) extending from a first end (112) of the second conduit section (104) to a second end of the second conduit section (104), the second conduit bore (138) including a second beveled surface (144) proximate the first end (112) of the second conduit section (104). The fluid system (100) further includes a coating (146) applied to the first beveled surface (128) and to the second beveled surface (144).
Patent CA-3141272-A1 (CA)
Title: A medium voltage switching apparatus
Inventor: MORELLI EMANUELE
IPC: H01H9/26
Filed: 2021-12-06
Abstract: A switching apparatus (1) for medium voltage electric systems, said switching apparatus comprising one or more electric poles (2), wherein, for each electric pole, said switching apparatus comprises: - a first pole terminal (11), a second pole terminal (12) and a ground terminal (13), said first pole terminal (11) being electrically couplable with a first conductor of an electric line, said second pole terminal (12) being electrically couplable to a second conductor of said electric line and said ground terminal (13) being electrically couplable to a grounding conductor; - a first contact arrangement (101) including a first fixed contact member (5A) and a first movable contact member (6A), said first fixed contact member being electrically connected to said first pole terminal (11) and including a first fixed contact (5), said first movable contact member (6A) being electrically connected to said second pole terminal (12) and including a first movable contact (6), said first movable contact member (6A) being reversibly movable about a corresponding first rotation axis (A1) according to a first rotation direction (R1) away from said first fixed contact (5) and towards said ground terminal (13) or according to a second rotation direction (R2), opposite to said first rotation direction (R1); - a second contact arrangement (102) including a second fixed contact member (8A) and a second movable contact member (9A), said second fixed contact member (8A) being electrically connected to said first pole terminal (11) and including a second fixed contact (8), said second movable contact member (9A) including a second movable contact (9) and being reversibly movable along a corresponding translation axis (A); - a vacuum chamber (10), in which said second fixed contact (8) and said second movable contact (9) are enclosed and can be coupled or decoupled; - an electrically conductive coupling lever (7) pivoted on said second movable contact member (9A) and reversibly movable about a second rotation axis (A2).
Patent CA-3141914-A1 (CA)
Inventor: GEOGHEGAN JAMES
IPC: C07K16/30
Filed: 2020-06-08
Abstract: L'invention concerne des domaines de liaison anti-CD3 dépendants du pH modifiés et des anticorps et/ou des domaines de liaison à l'antigène les comprenant, y compris des anticorps multispécifiques, présentant entre autres des profils souhaitables d'activation de lymphocytes T et de capacité de destruction de cellules cibles (re)dirigées et d'aptitude au développement, ainsi que des méthodes pour leur identification, leur isolement et leur génération, et leurs méthodes de préparation et d'utilisation. <i />
Patent CA-3142447-A1 (CA)
Title: Power head and outdoor power equipment using the same
Inventor: LI SHUHUA
IPC: H02J7/00
Filed: 2021-11-01
Abstract: The disclosure provides a power head and an outdoor power equipment using the same. The power head includes a housing assembly, a motor assembly and a battery pack assembly. The housing assembly includes a first housing and a second housing. The first housing and the second housing defines a housing space. The motor assembly is arranged in the housing space. The motor assembly includes a motor. One end of an output shaft of the motor extends to outside of the housing assembly. The battery pack assembly is arranged inside the housing space. The battery pack assembly supplies power for the motor assembly.
Patent CA-3145814-A1 (CA)
Title: Dispositif, systeme, procede et produit programme informatique pour identifier des dispositifs d'interference dans des mesures de position
Inventor: SEIBERT JOACHIM ULRICH
IPC: G01S19/03
Filed: 2020-06-30
Abstract: La présente invention concerne un dispositif de détection d'interférence (22) qui effectue les actions suivantes :  la réception de données de position individuelle provenant de terminaux mobiles (4(j)), ces données de position individuelle indiquant une zone (12(j)) dans laquelle des terminaux mobiles individuels parmi les terminaux mobiles (4(j)) sont situés sur la base de signaux de positionnement reçus par les terminaux mobiles (4(j));  le fait de déterminer si les données de position individuelle peuvent avoir été affectées par un ou plusieurs signaux d'interférence émis par un dispositif d'interférence (14(m)) et interférant avec les signaux de positionnement par  (A) le fait de déterminer si un nombre de terminaux mobiles (4v(j)) dans une première zone (18) est supérieur à un nombre seuil maximal, et, si tel est le cas, la détermination que les données de position individuelle du nombre de terminaux mobiles (4v(j)) peuvent avoir été affectées par les signaux d'interférence; et/ou  (B) le fait de déterminer si un nombre des terminaux mobiles (4(j)) dans une seconde zone (36) est inférieur à un nombre seuil minimal et, si tel est le cas, la détermination que les données de position individuelle du nombre de terminaux mobiles (4(j)) peuvent avoir été affectées par des signaux d'interférence; et/ou  (C) la réception de données de position individuelle supplémentaires qui indiquent d'autres zones (18) dans lesquelles des terminaux mobiles (4(j)) sont situés sur la base d'une autre technique de positionnement qu'une technique de positionnement utilisée pour déterminer les données de position individuelle telles que reçues en provenance des terminaux mobiles (4(j)); le fait de déterminer si les zones (12(j)) chevauchent les autres zones (18) au moins dans une certaine mesure et, si ce n'est pas le cas, la détermination que les données de position individuelle des terminaux mobiles (4(j)) peuvent avoir été affectées par les signaux d'interférence.