baber/WOPTO huggingface dataset:
Patent AU-2019257708-A1 (AU)
Title: Expression of human FOXP3 in gene edited T cells
Inventor: SCHARENBERG ANDREW M
IPC: C12N5/00
Filed: 2019-04-25
Abstract: Aspects of the invention described herein concern targeting of a FOXP3 cDNA, e.g., full-length human-codon optimized, into a FOXP3 locus or a non-FOXP3 locus so as to provide constitutive or regulated FOXP3 expression in a primary human lymphocyte. The compositions and materials described herein provide specificity for CRISPR/Cas-mediated gene regulation of murine, non-human primates or human FOXP3. Guide RNA sequences are used to target the FOXP3, AAVS1, and other candidate loci for CRISPR/Cas-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided. The alternative compositions described herein can be delivered in the form of Ribonucleoprotein (RNP) and may be used to target human and/or non-human primate FOXP3. Reagents are comprised of novel guide RNA sequences and can generate high frequency of on-target cleavage in combination with a Cas protein and novel gene delivery cassettes including FOXP3 cDNA +/-other cis linked gene products.
Patent AU-2019288683-A1 (AU)
Title: Antibody capable of inducing immune tolerance produced using cell mixture having complexed state, and induced lymphocyte or cell therapeutic agent and cell therapy method each using induced lymphocyte
Inventor: UCHIDA KOICHIRO
IPC: C12Q1/02
Filed: 2019-06-21
Abstract: The present disclosure provides a pharmaceutical composition for antigen-specific immune tolerance or immune suppression. The present disclosure provides a pharmaceutical composition comprising a CD4-positive anergy T cell and a CD8-positive anergy T cell. In some embodiments, the anergy T cell is induced by an antibody capable of inhibiting the interaction between CD80 and/or CD86 and CD28. In a specific embodiment, the pharmaceutical composition may additionally comprise a regulatory T cell (e.g., a FOXP3-positive CD4-positive CD25-positive T cell).
Patent AU-2019297474-A1 (AU)
Title: Distributed heating and cooling network
Inventor: BETZ MARTIN
IPC: F24D10/00
Filed: 2019-07-04
Abstract: A distributed heating and cooling network is described. In one aspect a distributed heating and cooling network used in a district heating architecture is described.
Patent AU-2019306490-A1 (AU)
Title: Updating infusion pump drug libraries and operational software in a networked environment
Inventor: XAVIER BEN
IPC: A61M5/00
Filed: 2019-07-12
Abstract: A distributed system provides update data to a plurality of infusion pumps within a clinical environment. A connectivity adapter receives drug library updates or operational software updates for infusion pumps over a network that is outside of the clinical environment. The connectivity adapter caches the blocks of update data and staggers streaming blocks of updated data to the infusion pumps over a network within the clinical environment.
Patent AU-2019344548-A1 (AU)
Title: Unique identities of endpoints across layer 3 networks
Inventor: PETERSON ANNIKA LEE LOUISE
IPC: H04L45/74
Filed: 2019-09-12
Abstract: Systems and methods provide for determining unique identities of endpoints across L3 networks. For example, a first networking device of a network management system in a first L3 network can receive a mapping of a first L3 network address to a first L2 network address from a second networking device in a second L3 network. The system can determine that the first L2 network address is associated with a third networking device. The system can receive a mapping of the L3 address to a second L2 network address from the third device. The system can determine that the second L2 address is associated with an endpoint. The system can store the L3 address and the second L2 address as an identity of the endpoint. The system can present network utilization information of the endpoint using traffic to/from the L3 address correlated to the endpoint based on its identity.
Patent AU-2019352834-A1 (AU)
Title: Carbon dioxide removal using sequestration materials that include salts in molten form, and related systems and methods
Inventor: HATTON TREVOR ALAN
IPC: B01D53/62
Filed: 2019-07-09
Abstract: The removal of carbon dioxide using sequestration materials that include salts in molten form, and related systems and methods, are generally described.
Patent AU-2019384669-A1 (AU)
Title: Apparatus and method for protecting cosmetic enhancements
Inventor: ROVEGNO NOELLE MARIE
IPC: A45D44/00
Filed: 2019-10-10
Abstract: An apparatus for protecting cosmetic enhancements, such as false eyelashes, eyelash extensions, or enhanced eyebrows from water, such as shower water, is disclosed. The protective apparatus may comprise a headband, a visor, and left and right ear pieces. The protective apparatus may be worn above a wearer's eyebrow lines and may adjust to create a water impervious seal with a wearer's forehead or face. A structure comprising a combination of the headband and left and right ear pieces' may create the water impervious seal between the protective apparatus and the wearer's face or forehead. A combination of all or any of the above-listed elements may support deflecting water from the cosmetic enhancements. The water impervious seal may minimize water seepage to the wearer's cosmetic enhancements. The present invention may include alternate formations for the visor and ear pieces.
Patent AU-2019386979-A1 (AU)
Title: Solid pharmaceutical preparation containing lipoic acid and use thereof
Inventor: JAIN SATISHKUMAR
IPC: A61K9/20
Filed: 2019-11-26
Abstract: The present invention relates to a solid pharmaceutical preparation comprising α-lipoic acid, dicalcium phosphate and a binder. The solid pharmaceutical preparation has an improved stability and thereby improved bioavailability.
Patent AU-2019392040-A1 (AU)
Title: Pharmaceutical composition, comprising inhibitory peptide against Fas signaling, for prevention or treatment of obesity, fatty liver, or steatohepatitis
Inventor: LEE SANG-KYUNG
IPC: A61K9/00
Filed: 2019-11-14
Abstract: The present invention relates to a pharmaceutical composition comprising an inhibitory peptide against Fas signaling as an active ingredient for prevention or treatment of obesity, fatty liver, or steatohepatitis. Binding specifically to Fas, which is extensively expressed in the liver and adipose tissues in an obese state, the inhibitory peptide against Fas signaling exhibits high delivery rates to inflammatory regions caused by obesity and directly inhibits the Fas signaling, which is a main inflammation signaling pathway, to inhibit an inflammatory response. Therefore, the peptide can be advantageously used for alleviating or treating obesity, fatty liver, or steatohepatitis.
Patent AU-2019403451-A1 (AU)
Title: Modular spine stabilization system and associated instruments
Inventor: ECKHOF STEPHAN
IPC: B21D7/00
Filed: 2019-12-20
Abstract: An implantable, modular spine stabilization system that allows for multi-level treatment of the spine by providing either rigid fixation or dynamic stabilization at different levels to be treated is provided. This modular spine stabilization system may be configured to span multiple spine levels, and have a curvature that closely matches the curvature of the spine over those multiple levels to be treated. Further, the modular spine stabilization system allows adjustment of the curvature of the overall system such that the system may be adapted for a patient for a customized fit. Instruments are also provided for the assembly and/or implantation of the modular spine stabilization system. The associated instruments may include instruments for adjusting the curvature of the system to the patient, and for implanting the curved system into the patient. The instruments may be configured for implantation of the system in a minimally invasive surgery.
Patent AU-2019410394-A1 (AU)
Title: Lift rail
Inventor: BÜTLER ERICH
IPC: B66B7/04
Filed: 2019-12-19
Abstract: Lift rail (2) which serves for guiding cars (3) of a lift system (1). The cars (3) serve, in particular in the form of cabins (4), for transporting people or goods, or as a counterweight (5). The lift rail (2) has more than one guide contour (6). The guide contour (6) is suitable for interacting with a guide shoe (11) such that, in a first horizontal direction (7), a relative horizontal displacement between the guide contour (6) and guide shoe (11) is delimited at least on one side, and that, in a second horizontal direction (8), perpendicular to the first, a relative horizontal displacement between the guide contour (6) and guide shoe (11) is delimited on both sides. The lift rail (2) has a closed-surround cross section. The lift rail (2) has at least three guide contours (6), which are formed on the outer surface of the lift rail (2).
Patent AU-2019427482-A1 (AU)
Title: Remotely adjustable mechanism and associated systems and methods
Inventor: CULLY EDWARD H
IPC: A61B17/12
Filed: 2019-02-01
Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a medical device including a remotely actuated cross-sectional adjustment mechanism. The medical device may include a cross-sectional adjustment mechanism configured to actuate an implantable medical device between a first dimension and a second dimension that is larger than a first dimension to adjust an amount of fluid flow through the implantable medical device.
Patent WO-2020248013-A1 (WO)
Inventor: STAGER STEPHANIE
IPC: F16K27/02
Filed: 2020-06-11
Abstract: A valve device including: a regulating portion having: an insert with an insert inlet, an insert outlet and a hollow portion; a moving portion extending at least partway through the hollow portion of the insert, the moving portion moving a regulating part that assists in substantially controlling fluid flow at a set outlet pressure by a position thereof relative to the hollow portion; and a pressure reactive member connected to the moving portion such that movement of the pressure reactive member adjusts the position of the moving portion, the pressure reactive member configured to be in communication with a chamber portion that provides an adjusting force based on outlet pressure to assist in achieving the set outlet pressure, wherein a sealing portion encloses the insert outlet, the sealing portion being configured to engage with a body that is in fluid communication with the insert outlet.
Patent AU-2020200012-A1 (AU)
Title: Computer docking station
Inventor: VOLEK ROBERT
IPC: H01R33/945
Filed: 2020-01-02
Abstract: COMPUTER DOCKING STATION A computer docking station (1) devised to save desktop space while also eliminating the presence of permanent cables that can clutter the work surface is disclosed. The computer docking station (1) utilizes a split design, with a lower dock subassembly (40) positioned beneath the work surface for housing the permanent cables necessary for the computer workstation to operate and an upper dock subassembly (20) comprising one or more data ports positioned on top of the work surface. A monitor arm mount can be attached to, or integrated into, the upper dock subassembly (20), thereby alleviating the need for a separate monitor arm mount without negatively impacting the docking station's footprint.
Patent AU-2020200822-A1 (AU)
Title: KVM extender receiving end provided with switching device
Inventor: ZHOU LIGANG
IPC: G06F3/023
Filed: 2020-02-05
Abstract: Abstract The invention is KVM extender receiving end provided with switch device. It includes video decoder, mouse and keyboard encoder and switch device, the input end of video decoder is connected to switch device. The output end of mouse and keyboard encoder is connected to switch device. Advantages: It will separate the intranet and the internet of the department. It will not only prevent hacker's attack but also effectively prevent internal staff from network leak. It can place two computers into the computer room, which is far away from personal office station and save a lot of office space for each office worker. The Attached Pictures for the Summary Picture 1
Patent AU-2020201367-A1 (AU)
Title: Compact Scour
Inventor: ESSON CHARLES EDWARD
IPC: D01B3/08
Filed: 2020-02-25
Abstract: A scour for cleaning fibres in which the fibres are transported between a series of 
perforated belts, allowing flexibility in machine configuration including a vertical 
arrangement of successive cleaning/rinsing passes. This allows for a compact scour 
suitable for a variety of fibres whilst minimising fibre entanglement.
2/4 
10 
108 
107 
13 
106 12 
105 
104 
102 103 
101 11 
Figure 2
Patent AU-2020202834-A1 (AU)
Title: Wine cabinet
Inventor: PANG WAI TUNG PETER
IPC: A47B73/00
Filed: 2020-04-29
Abstract: : 
The present invention relates to a wine cabinet, which comprises a main cabinet 
body, and further comprises a transparent display cabinet body arranged at a top end 
5 of the main cabinet body, a control mechanism, a driving mechanism connected with 
the control mechanism, and an automatic lifting and sliding mechanism connected 
with the driving mechanism, wherein a display chamber of the display cabinet body 
is separated from a storage chamber of the main cabinet body by a laminated plate, 
the control mechanism, the driving mechanism and the automatic lifting and sliding 
o mechanism are arranged in the storage chamber, an opening is arranged at a side of 
the top end of the display cabinet body, the opening is covered with a transparent 
movable cover plate, the automatic lifting and sliding mechanism is connected with 
the movable cover plate, and the automatic lifting and sliding mechanism can be 
driven to move in the storage chamber by the driving mechanism and can drive the 
5 movable cover plate to move, so as to open or close the opening of the display 
cabinet body. The wine cabinet according to the present invention can realize 
multiple functions, and space cannot be occupied when opening the display cabinet 
body.
Patent AU-2020205424-A1 (AU)
Title: Organomodified polysiloxanes and their use for defoaming fuels
Inventor: PEGGAU JÖRG
IPC: C10L1/28
Filed: 2020-01-07
Abstract: The invention relates to organomodified polysiloxanes, to compositions, particularly fuel compositions, containing said organomodified polysiloxanes, and to the use of the organomodified polysiloxanes for defoaming fuels.
Patent AU-2020223731-A1 (AU)
Title: JAK2 and ALK2 inhibitors and methods for their use
Inventor: MOLLARD ALEXIS
IPC: C07D401/14
Filed: 2020-08-27
Abstract: C:\Users\kzh\AppDat\Local\TempinMailX\i\0015\a\U\i\Absact - 35518948.DOCX-1/l 1/2018 
ABSTRACT 
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed.  
The compounds have the following structure (I): 
Re 
X" R 7 
R6 R 3 
(R 5+1NN R2 
IR 
R 4 
(I) 
including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, 
1 2 3 4 5 6 7 8 wherein R , R2, R', , R, R, R, R, X, z and A are as defined herein. Methods associated 
with preparation and use of such compounds, as well as pharmaceutical compositions 
comprising such compounds, are also disclosed.
WO 2014/151871 PCT/US2014/026595 
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Drug No.7 No.4 No.10 No.20 No.12 No.11 No.23 
HEPG2 cells treated with 1pM compound 
FIG.1 
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1.2 
0 
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0.8 
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FIG. 2
Patent AU-2020223768-A1 (AU)
Title: Treatments for migraine and related disorders
Inventor: KRAIG RICHARD
IPC: C12P21/02
Filed: 2020-08-28
Abstract: Embodiments are directed to compositions and methods of treating migraine and 
related neurological disorders. In certain aspects, methods and compositions are for reducing 
cortical spreading depression and/or suppressing the neurochemical basis for chronic and 
acute migraine events, and provide methods and pharmaceutical compositions related to both 
acute and preventive therapies for migraine events and related headaches.
Patent AU-2020226141-A1 (AU)
Title: A mounting device
Inventor: ELLARD ROBIN JAMES
IPC: H02S20/23
Filed: 2020-02-18
Abstract: The present invention is directed broadly to a mounting assembly (500) of a height safety system. The mounting assembly (500) broadly comprises: 1. a body defining a cavity (522) adapted to receive a raised portion of a roof, the body including a pair of separable side portions (502) and (504) configured for sliding engagement for interlocking with one another wherein the cavity (522) includes an enlarged end portion for receiving an enlarged end portion of the raised roof portion, and a relatively narrow neck portion for receiving a neck portion of the raised roof portion and being configured on interlocking of the separable side portions (502) and (504) to prevent removal of the mounting assembly 500 from the raised roof portion; 2. one or more anchor fasteners arranged to engage the body at (518) for both: a) mounting of a roof anchor of the height safety system to the mounting assembly (500); and b) interengagement of the pair of separable side portions (502) and (504) to prevent sliding movement of said side portions (502) and (504) relative to one another.
Patent AU-2020239809-A1 (AU)
Title: Crop harvesting blade system
Inventor: RICKARDS MARK
IPC: A01D34/73
Filed: 2020-09-25
Abstract: A crop harvesting blade is provided for use in a mechanical crop harvesting machine to 
improve ratooning e.g. a chopper harvester for harvesting sugar cane. The crop harvesting 
blade has a plurality of rectangular teeth located at and uniformly arranged along the entire 
periphery of the blade body. The blade also has an attachment arrangement configured to 
provide a plurality of attachment positions for releasable attachment of the blade body to a 
base plate of a cutting portion of a mechanical crop harvesting machine. Upon attachment 
of the blade body to the base plate in each attachment position, the corresponding portion 
of the plurality of teeth is placed in an operative position.
1/5 
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O O 
O- O G 
o~ OJ 
124 0 0 124 
122 122 
120~~ig 10002
Patent AU-2020244382-A1 (AU)
Title: Ezh2 inhibitors for treating lymphoma
Inventor: KEILHACK HEIKE
IPC: A61P35/00
Filed: 2020-09-28
Abstract: The present invention relates to methods of treating cancer by administering an EZH2 
inhibitor or a pharmaceutical composition thereof to the subject in need thereof. The present 
claims define methods for treating specific subtypes of non-Hodgkin's lymphoma comprising 
the administration to a subject of EZH2 inhibitors. Preferred EZH2 inhibitors include 
tazemetostat (EPZ-6438 E7438) and other compounds. Dosage amounts and regimes are also 
defined.
Patent AU-2020244861-A1 (AU)
Title: Quinoline derivatives and their use for the treatment of cancer
Inventor: COMER EAMON
IPC: C07D471/04
Filed: 2020-03-27
Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.
Patent AU-2020256188-A1 (AU)
Title: Graphene polyethylene terephthalate composite for improving reheat energy consumption
Inventor: HANAN JAY CLARKE
IPC: C01B32/182
Filed: 2020-04-01
Abstract: A graphene reinforced polyethylene terephthalate composition is provided for forming graphene-PET containers. The graphene reinforced polyethylene terephthalate composition includes a continuous matrix comprising polyethylene terephthalate and a dispersed reinforcement phase comprising graphene nanoplatelets. The graphene nanoplatelets range in diameter between 5 μm and 10 μm with surface areas ranging from about 15 m
Patent AU-2020264300-A1 (AU)
Title: HIV Inhibitor Compounds
Inventor: BACON ELIZABETH M
IPC: A61K31/4155
Filed: 2020-11-04
Abstract: The invention provides a compound of Formula 1: or a pharmaceutically acceptable salt thereof as 
described herein. The invention also provides pharmaceutical compositions comprising a compound 
of Formula 1, processes for preparing compounds of Formula 1, the compound of formula (1) for use in 
therapeutic methods fortreatingthe proliferation of the HIVvims, treatingAIDS ordelayingthe onset 
of AIDS symptoms in a mammal using compounds of Formula 1. Preferred compounds are N-[(2S)-1
[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4
phenylbutyl]-2-[(phenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate atazanavir (ATV) 
analogues substituted by several heterocycles, such as e.g. pyrazole (R1); e.g. oxetane (substituent of 
X2); e.g. pyridine or pyrimidine (X1); e.g. piperazine or 3,8-diazabicyclo[3.2.1]octan (X2).  
R 
R'On 
5 
O R RH OH O 
R2kN , N N N 
R3 
HR7 RH R 
A 
1X 
~x(
Patent AU-2020264383-A1 (AU)
Title: Tool storage units with integrated power
Inventor: DOERFLINGER DAVID A
IPC: B25H3/02
Filed: 2020-11-06
Abstract: The present invention broadly relates to a tool storage unit with an integrated power strip.  
In some embodiments, the power strip is movable with a compartment of the tool storage unit. In 
other embodiments, the power strip is stationary. The compartment is adapted to provide access 
to the power strip when the compartment is open.  
66401109v.3
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20aa 
104 
310 
118 
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ea 
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120 'ai 
426 3a0 
04l
Patent AU-2020265509-A1 (AU)
Title: Customized output to optimize for user preference in a distributed system
Inventor: YOSHIOKA TAKUYA
IPC: G06F40/40
Filed: 2020-03-17
Abstract: Systems and methods for providing customized output based on a user preference in a distributed system are provided. In example embodiments, a meeting server or system receives audio streams from a plurality of distributed devices involved in an intelligent meeting. The meeting system identifies a user corresponding to a distributed device of the plurality of distributed devices and determines a preferred language of the user. A transcript from the received audio streams is generated. The meeting system translates the transcript into the preferred language of the user to form a translated transcript. The translated transcript is provided to the distributed device of the user.
Patent AU-2020298533-A1 (AU)
Title: Tissue repair device
Inventor: BEST JOSHUA J
IPC: A61B17/04
Filed: 2020-07-01
Abstract: Tissue repair devices that has a movable inserter configured to support a suture implant construct that is positioned for deployment and methods for using the devices.
Patent AU-2020314455-A1 (AU)
Title: Time-division duplex multiple-input multiple-output calibration
Inventor: CHEN JINGHU
IPC: H04B17/12
Filed: 2020-07-01
Abstract: Aspects of this disclosure relate to a time-division duplex (TDD) multiple‑input multiple-output (MIMO) system that includes a plurality of nodes. The plurality of nodes collectively includes antennas divided into groups. Reference signals can be transmitted from each group of antennas to one or more other groups of antennas during respective time slots. Channel estimates can be generated based on the received reference signals. The channel estimates can be jointly processed to generate calibration coefficients. Each calibration coefficient can represent a ratio associated with a transmit coefficient and a receive coefficient. Example algorithms for the joint processing are disclosed.
Patent AU-2020323594-A1 (AU)
Title: Antiarrhythmic formulation
Inventor: HURREY MICHAEL LAIRD
IPC: A61K31/445
Filed: 2020-07-30
Abstract: Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.
Patent AU-2020367242-A1 (AU)
Title: Influenza virus vaccines and uses thereof
Inventor: BRANDENBURG BOERRIES
IPC: A61K39/145
Filed: 2020-10-15
Abstract: Provided herein are isolated mutant influenza hemagglutinin polypeptides, methods for providing isolated mutant hemagglutinin polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.