baber/WOPTO huggingface dataset:
Patent JP-2002515895-A (JP)
Title: フェノキシ酢酸誘導体及び除草剤としてのその使用
IPC: C07D307/22
Filed: 1998-01-30
Abstract: (57)【要約】
本発明は、式（Ｉ）（式中、Ｒ 1 、Ｒ 2 、Ｘｎ及びＡは、説明で定義された通りであり、Ａは、ハロゲン原子、ヒドロキシ、ＯＲ 3 、Ｓ（Ｏ） k Ｒ 3 又は式（Ａ−１）若しくは（Ａ−２）の基（式中、Ｒ 3 〜Ｒ 5 及びｋは説明で与えられた意味を有する）を表わす）のフェノキシ酢酸誘導体及び除草剤としてのその使用に関する。
Patent JP-2000507577-A (JP)
IPC: A61B5/055
Filed: 1997-03-25
Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
Patent JP-2001526853-A (JP)
Title: データ符号化ネットワーク
IPC: G06T9/00
Filed: 1998-03-06
Abstract: (57)【要約】
好ましい符号化ネットワークは、ベース−フィルタ−リソース(Base-Filter-Resource(BFR))システムと呼ばれるアーキテクチャを使用する。この手法は、フォーマット仕様圧縮の有利な点を、広範囲なデータフォーマットを提供する汎用圧縮ツールに統合する。ソースデータは共通データのブロックに分解され、各分解されたブロックは、それぞれ選択された圧縮アルゴリズムを用いて圧縮される。アルゴリズムは静的モデルから選ばれるか、または、分解されたブロックのデータに適応されうる。分解されたブロックは、エンコードデータファイルに結合される。デコードでは、上記処理とは逆の処理がなされる。
Patent JP-2001527537-A (JP)
IPC: A61K38/095
Filed: 1998-03-26
Abstract: Substances having oxytocin activity can be used for the preparation of a pharmaceutical composition for treatment or prophylaxis of affective pain syndromes, such as fibromyalgia and navel colic. The pain relieving effect can be strengthened or prolonged by combining oxytocin with oestrogen.
Patent JP-2000500893-A (JP)
Title: 妨害予測器を有する制御ユニットと、このような制御ユニットによって制御されるシステムと、このような制御ユニットによって制御される電気アクチュエータと、このようなアクチュエータを設けたスロットル装置
IPC: H02P23/16
Filed: 1997-04-30
Abstract: (57)【要約】
システムの第１状態変数、例えば、内燃機関において使用するスロットル装置のスロットルバルブ（７）の回転角（φ）を制御する制御ユニット（７５）であって、前記システムは、動作中に妨害変数、例えば、前記スロットル装置において空気流変動によって生じる振動する負荷トルクによって影響を受ける。制御ユニット（７５）は、前記システムの数学モデルに基づいて前記妨害変数の値を計算する妨害観測器（１２５）と、前記妨害変数の値を、前記値が妨害観測器（１２５）によって計算される第１時点の予め決められた期間後の第２時点に対して予測する妨害予測器（１２８）とを具える。このようにして、前記システムに実際に影響を与える妨害変数と、前記システムによって実現される前記妨害変数に対する補償との間の位相シフトを、前記妨害変数の高い周波数において防ぐ。特別な実施形態において、妨害予測器（１２８）は、学習段階および試験段階を有する人工ニューラルネットワーク（２０７）を具える。他の実施形態において、妨害予測器（１２８）は、ニューラルネットワーク（２０７）が学習段階である場合、妨害観測器（１２５）によって計算された前記妨害変数の値に対応する信号を供給し、ニューラルネットワーク（２０７）が試験段階である場合、前記第２時点に対して予測される前記妨害変数の値に対応する信号を供給する。
Patent JP-2000511418-A (JP)
Title: ヒトインターロイキン―１ｊおよびそのアンタゴニスト
IPC: C07K16/24
Filed: 1997-05-16
Abstract: (57)【要約】
ヒトIL-1γをコードする核酸、ならびに精製されたIL-1γタンパク質およびそのフラグメントが提供される。ポリクローナルおよびモノクローナル抗体、ヒトIL-1γのアゴニストまたはアンタゴニストであり得る抗IL-1γ抗体および抗イデオタイプ抗体の両方が提供される。診断的有用性および治療的有用性の両方のための組成物を使用する方法もまた、ヒトIL-1γのアンタゴニストおよびレセプターとともに提供される。
Patent JP-2001523302-A (JP)
Title: ポリブテン−１（共）重合体およびそれらの製造方法
IPC: C08F4/658
Filed: 1999-03-02
Abstract: (57)【要約】
本発明は、以下の特性を有するポリブテン−１単独重合体またはブテン−１のほかに２〜１０の炭素原子を有するアルファ−オレフィンを20重量％まで含む共重合体に関する。：（ｉ）以下に特定された方法に従ったＮＭＲ分析により測定されたアイソタクチック  インデックス（ｍｍｍｍ％）が93より高い；（ii）以下に特定された方法に従ったＧＰＣ分析により測定された分子量分布（ＭＷＤ）がＭｗ／Ｍｎで６より高い；そして（iii）Ｔｉ  ｐｐｍで表わされる触媒残渣の含量が50より低い。この重合体は、改善された耐クリープおよび耐破裂応力を有する物品、特にパイプの製造に極めて適している。
Patent JP-2001526721-A (JP)
IPC: C09D5/00
Filed: 1998-05-14
Abstract: A process for treating food-contact surfaces is presented in which a surface treatment composition is applied to a food-contact surface. The surface treatment composition contains 90 to 98.5% by weight of water, 1 to 4% by weight of a hygroscopic component, 0.2 to 2% by weight of a preservative, and a thickener added in such a quantity so that the viscosity of the surface treatment composition is in the range of from 2,000 to 10,000 mPas, as measured at 22° C. with a Brookfield viscometer, spindle 3, at 12 r.p.m.. Surfaces treated by this process are easily freed of adhering soils by wiping with a damp cloth or by spraying with water.
Patent JP-2000517057-A (JP)
Title: 結合測定を実行するための方法およびシステム
IPC: G01N27/447
Filed: 1998-05-08
Abstract: (57)【要約】
結合測定を実行する方法は、複数のサンプル切片を複数のサブサンプルに分離し、複数のサブサンプルの各々を複数の結合アッセイの個別の１つに適応する段階（２２，２４）によって構成される。上記の段階を実行するシステムも開示される。
Patent JP-2002506598-A (JP)
Title: 無線システムのテレコミュニケーション接続をテストする方法
IPC: H04W24/00
Filed: 1999-04-28
Abstract: (57)【要約】
本発明は、テレコミュニケーション接続によって作動的に相互接続された１つ以上のネットワーク要素(316，324，326，328，334，336)、ベースステーションコントローラ(302)及びネットワークマネージメントシステム(300)を備えた無線システム、及びこの無線システムにインストールされるべきネットワーク要素のテレコミュニケーション接続をテストする方法に係る。ネットワーク要素間の情報は、タイムスロットに分割されたフレームにおいて送信され、そしてベースステーションコントローラは、テレコミュニケーション接続によりシステムに物理的に接続される１つ以上のネットワーク要素を制御する。ネットワーク要素を確実且つ迅速にインストールできるようにするために、ネットワーク要素は、ネットワーク要素のテスト準備ができたという情報を含むメッセージをベースステーションコントローラへ送信する。ベースステーションコントローラは、上記メッセージを受信した後にテスト手順を開始する。このテストは、ベースステーションコントローラとネットワーク要素との間の全てのチャンネルを含む。
Patent JP-2002511771-A (JP)
Title: 新規なカルボキシペプチダーゼインヒビター
IPC: C12N15/57
Filed: 1998-06-10
Abstract: (57)【要約】
本発明は、ヒトカルボキシペプチダーゼインヒビター（ＣＡＲＩＮ）及びＣＡＲＩＮを同定しコードするポリヌクレオチドを提供する。また本発明は、発現ベクター、宿主細胞、アゴニスト、抗体、及びアンタゴニストを提供する。また本発明は、ＣＡＲＩＮの発現に関連する疾患の治療方法を提供する。
Patent MD-20020020-A (MD)
Title: Association of digestive tube obligate microorganisms capable of synthesizing the B-group vitamins
Inventor: LEORDA ANA
IPC: A61K35/74
Filed: 2001-12-26
Abstract: The invention refers to microbiology and may be used in obtaining the curative-prophylactic medicines used for increasing the B-group vitamins synthesis in the digestive tube. The proposed association of microorganisms comprises two strains Bifidobacterium longum var. animalis No. 527 and Lactobacillus acidophilus No. 417, possessing a pronounced capacity of synthesis of B1, B2 and B3 vitamins.The result of the invention consists in increasing the level of synthesis of B-group vitamins with the obligate microorganisms of the digestive tube.Claims: 1
Patent NZ-193574-A (NZ)
Title: Forming corrugated filter sheet using fan-shaped fold-former
Inventor: ROSENBERG D
IPC: B01D46/52
Filed: 1980-04-30
Abstract: Process and apparatus are provided for forming corrugated filter sheet by folding a long strip of sheet material into corrugations extending longitudinally of the strip, press-bending the sheet along the longitudinal fold lines of the intended corrugations; and gradually drawing in the sheet from the sides towards the center, while pushing the sheet out from each side along the fold lines, so as to form the intended corrugations, reducing the width of the sheet according to the height and width of the corrugations.
Patent NZ-208579-A (NZ)
Title: Encapsulating organic compounds whose solubility varies according to ph
Inventor: FRANK SYLVAN GERALD
IPC: A61K9/58
Filed: 1984-06-19
Abstract: Process for the formation and the simultaneous encapsulation of small particles of a compound from solution.
Patent NZ-226929-A (NZ)
Title: Storing produce in container with controlled atmosphere: carbon dioxide supplied from store of dry ice
Inventor: WOODRUFF RICHARD EARL
IPC: B65D88/74
Filed: 1988-11-11
Abstract: The invention provides a method of, and apparatus for, storing produce under controlled conditions. The invention is advantageously embodied in a transport container (5) so that produce is maintained under controlled conditions during transportation. As with many controlled atmosphere storage or transportation systems, a nitrogen-rich gas and carbon dioxide gas are supplied to the container (5) when required. However, to provide a compact and efficient system, the invention provides that the nitrogen gas be generated from the ambient air surrounding the container using an air splitter (35) while the carbon-dioxide is generated from a store (40) of dry-ice.
Patent NZ-236936-A (NZ)
Title: Mobile station authentication
Inventor: DENT PAUL WILKINSON
IPC: H04L9/32
Filed: 1991-01-29
Abstract: A method for carrying out an authentication check in a mobile telephone system in which an authentic base station (BS) serves a plurality of mobile stations (MS1-MSn). It is earlier known to carry out a unidirectional check from the base station (BS) to a calling mobile station (MSk). A false base station (BSf) is able, in this way, to carry out a false authentication check, by collecting a number of so-called RAND-Response pairs. In order to avoid this, there is introduced a further unidirectional authentication check, base station-mobile station, and also an authentication check from the mobile station to the base station. According to one embodiment of the method, the unidirectional check is excluded and only the bidirectional authentication check is carried out. <IMAGE>
Patent NZ-241945-A (NZ)
Title: Auxiliary signal transmitted over optical fibre by modulating gain of amplifier
Inventor: LETELLIER VINCENT
IPC: H04B10/29
Filed: 1992-03-12
Abstract: This system for transmitting, over an optical link, a signal referred to as auxiliary with respect to a traffic signal transmitted simultaneously over this link, for optical link comprising at least one rig itself comprising means (1) of optical amplification of incident optical signals, comprises essentially, for the transmission of an auxiliary signal by the said rig, means (2, 4, 5, 6) of modulating the gain of the optical amplification means of this rig by the said auxiliary signal. <IMAGE>
Patent NZ-256246-A (NZ)
Title: Serine leukocyte protease inhibitor, recombinant preparation thereof, and treatment of a retroviral infection
Inventor: EISENBERG STEPHEN
IPC: C07K14/81
Filed: 1993-09-09
Abstract: Methods and pharmaceutical compositions are provided to prevent retroviral infections of host cells. More particularly, the invention relates to prevention of HIV infection of human cells by serine leukocyte protease inhibitor (SLPI).
Patent NZ-286388-A (NZ)
Title: Esters of 2-(2,6-dihalophenylamino)phenylacetoxyacetic acid with a diolmononitrate and amides with a nitrate ester of an alkanolamine
Inventor: MASIA XAVIER SERRA
IPC: C07C227/16
Filed: 1996-04-17
Abstract: Nitric esters of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid derivatives with the formula (I), where: ÄA  IDENTICAL  F, Cl or Br; X  IDENTICAL  O, NH or NR (R  IDENTICAL  C1 - C8 alkyl); R1 and R2 independently  IDENTICAL  C1 - C8 alkyl and n is a whole number from 1 to 10. The procedure includes the condensation of 2-(2,6-diahlophenylamino) phenylacetoxyacetic acid with a compound with the formula: <CHEM> where Y  IDENTICAL  OH, NH2 or NHR and Z is Cl, Br or ONO2.a
Patent NZ-290896-A (NZ)
Title: Solid dose delivery composition containing a glassy vehicle and at least one guest substance
Inventor: ROSER BRUCE JOSEPH
IPC: A61K9/16
Filed: 1995-08-04
Abstract: A device for the topical subcutaneous, intradermal or transdermal delivery of a therapeutic agent, wherein the device includes a composition comprises the therapeutic agent and a glass-forming polyol and/or a hydrophobic derivatised carbohydrate (HDC) having a carbohydrate backbone up to pentasaccharide in length, wherein more than one hydroxyl group of the carbohydrate is substituted with a less hydrophilic derivative thereof.
Patent NZ-306156-A (NZ)
Title: Stable protein-phospholipid composition and its use as a carrier
Inventor: COLLINS DAVID S
IPC: A61K47/48
Filed: 1996-03-28
Abstract: The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid vesicle, thereby stabilizing the protein against thermally-induced aggregation, denaturation, and loss of activity. The protein:phospholipid complex directly stabilizes the secondary and tertiary structure of the protein, and the compositions are useful in high temperature formulations and in novel delivery vehicles.
Patent NZ-316609-A (NZ)
Title: Lyophilized thioxanthenone antitumor agents
Inventor: BROWN STEPHEN
IPC: A61K47/26
Filed: 1996-09-12
Abstract: Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a lactate buffer.
Patent NZ-332027-A (NZ)
Title: A granular media filter for removing impurities from water having a plurality of elongate through orifices for use in a water treatment plant used in conjunction with a porous granular bed Dirt is removed by passing water in the opposite direction at a higher rate than the forward flow
Inventor: STEVENSON DAVID GORDON
Filed: 1998-09-22
Abstract: A system for backwashing filter media off a filter bed of the figure 1, including a plurality of devices for admitting a backwashing medium for passage through the bed in a direction opposite that of filtration, and a plurality of further devices for admitting a further backwashing medium for passage through the bed in the direction, each further device having a plurality of elongate through orifices adapted to allow passage, through of the further backwashing medium but not of the filter media.
Patent NZ-334624-A (NZ)
Title: Mould including biasing means that yields against the expansive pressure of produce during freezing
Inventor: WYBORN LINDSAY GEORGE
IPC: A23P1/00
Filed: 1997-08-22
Abstract: A mould 1 for preforming produce in a frozen state, includes top, bottom and side surfaces and biasing means that yields against the expansive pressure of the produce during freezing.  The top, bottom and side surfaces of the mould are configured so that the mould is self-supporting against the forces of expansion by the produce during the freezing process.  The top and bottom surfaces of the mould may be reinforced.  The biasing means may include at least one plate positioned on at least one of the surfaces of the mould.  The biasing means may include at least one flexible diaphragm, a spring 8 or a concave base and a convex lid.
Patent NZ-335353-A (NZ)
Title: Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases including AIDS or HIV
Inventor: BROWING JEFFREY
IPC: C07K16/24
Filed: 1997-10-24
Abstract: The use of a LT-b-R blocking agent in the preparation of a medicament for altering the humoral immune response in an animal by inhibiting the LT-b-R signaling pathway.  The blocking agent is selected from the group consisting of soluble lymphotoxin-b receptor comprising human immunoglobulin Fc domain, an antibody directed against LT-b receptor, and an antibody directed against surface LT ligand.  Also disclosed is a pharmaceutical composition and it's use for the treatment of AIDS or HIV, comprising AZT, a protease inhibitor and a blocking agent of LT-b-R.
Patent NZ-335387-A (NZ)
Title: Acylated cyclodextrin derivatives used as inclusion complexes to mask the bitter taste or odour, solubilize hardly soluble compounds or stabilise compounds
Inventor: SHALABY SHALABY W
IPC: A61K47/48
Filed: 1997-10-06
Abstract: A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of the cyclodextrin are acylated with acyl groups where at least one of the acyl groups comprise a free carboxylic group.
Patent NZ-335723-A (NZ)
Title: Segmented smelt spout for black liquor furnace
Inventor: BEVERIDGE CHRISTOPHER J
IPC: B01J4/00
Filed: 1997-11-10
Abstract: A segmented smelt spout for a black liquor furnace 12 is made up of a series of  units 30, 32.  One unit 30 is an end unit.  Each unit is in the form of a U-shaped trough.  The end unit 30, which forms the furnace end of the spout has a recess at one end for receiving a protrusion on an adjacent unit 32, and lugs for retaining the end of a tensioning cable 56.  The units 32 have a recess at one end for receiving a protrusion on the adjacent unit 32, and the protrusion at the other.  One or more of the units 32 may be curved along its longitudinal axis.  The segments are held together by the tensioning cable.
Patent NZ-501065-A (NZ)
Title: Form-work support arrangement having a sliding riser supported by a buttress and horizontally slidable in a plane transverse to a form-work location
Inventor: VINET ALEXANDER JOSEPH
IPC: B28B7/02
Filed: 1998-04-28
Abstract: A form-work support arrangement which enables concrete panels to be moulded horizontally one on top of the other comprising a side-form (1), a sliding riser (24, 25, 26, 27, 28 and 29) that supports the side-form at a form-work location, the sliding riser being slidable in a first plane, a set-back buttress for supporting the sliding riser for sliding movement in the first plane. At the base of the set-back buttress is an anchor plate (11). Rising from the anchor plate is a sliding riser frame (12). This consists of four buttress legs (13, 14, 15 and 16) which permits the stacking of six sliding risers. The set-back buttress (10) being fixed to a work-site surface at a position set back from the form-work location. The sliding riser being slidable in a first plane between a first position in which it laterally supports the side-form and a second position in which it does not support the side form and lies clear of the side form so as to provide an unobstructed access to the form-work location.
Patent NZ-501337-A (NZ)
Title: A pulsator for phased teat cup pairs
Inventor: JOHANNESSON LEIF BORJE
IPC: A01J5/12
Filed: 1998-05-22
Abstract: A milking machine pulsator includes a first circuit having a first outlet 2 to a teat cup pair and a second outlet to another teat cup pair, connected, by displacement of valve 4, alternately to a first (vacuum) pressure level and a second (atmospheric) pressure level, respectively. The valve is displaceable by the pressure difference between the chambers 10, 11.  A second circuit, for controlling the displacement of the valve 4, includes a first inlet (17a, 17b) connected to the first (vacuum) pressure level, a second inlet (18a, 18b) connected to the second (atmospheric) pressure level, and valve members (19a, 19b).  The second circuit can be switched between respective stable positions, in the first of which the inlet 17a is connected to the first chamber 10 and the second inlet 18b is connected to the second chamber 11, and in the second of which the first inlet 17b is connected to the second chamber 11 and the second inlet 18a is connected to the first chamber 10.   The valve members 19a,b of the second circuit include control inlets 26a,b with a closing member 27a, b that at a rest position close the control inlets and by an opening of short duration connecting the control inlets to the second pressure source, effect the switching of the second circuit between one stable position to the other.
Patent NZ-507010-A (NZ)
Title: 2-Benzo[d]isoxazol-3-yl-octahydro-pyrido[1,2-a]pyrazine useful as 5HT1 receptor ligands
Inventor: BRIGHT GENE MICHAEL
IPC: C07D471/04
Filed: 1999-03-18
Abstract: Compounds of the formula (I) and their salts that are useful as psychotherapeutic agents are disclosed wherein: R3, R4, and Z are selected, independently, from hydrogen, halo (e. g., chloro, fluoro, bromo or iodo), (C1-C4) alkyl optionally substituted with from one to three fluorine atoms, (C1-C4) alkoxy optionally substituted with from one to three fluorine atoms, and (C1-C4)alkoxy-(C1-C4)alkyl wherein each of the alkyl morieties may optionally be substituted with from one to three fluorine atoms; W is -CH2-O-(C1-C6) alkyl wherein the alkyl moiety can be straight or branched, or W is-CH2NR1R2 wherein R1 and R2 are independently selected from hydrogen and straight or branched (C1-C6)alkyl; or R1 and R2 together with the nitrogen to which they are attached, form a saturated or unsaturatted nonaromatic four to seven membered monocyclic or a seven to ten membered bicyclic ring which may optionally contain one or two heteroatoms in addition to the nitrogen of NR1R2, wherein said heteroatoms are independently selected from oxygen, nitrogen and sulfur, and wherein from one to three of the ring carbon atoms or one of the ring nitrogen atoms may optionally and independently be substituted with (C1-C4) straight or branched alkyl, (C1-C4) straight or branched alkoxy, (C1-C3) straight or branched alkyl-(C3-C7) cycloalkyl, hydroxy, amino, cyano, halo, aryl- (C1-C3) straight or branched alkyl or heteroaryl-(C1-C3) straight or branched alkyl, wherein said aryl is selected from phenyl and naphthyl and said heteroaryl is selected from oxazolyl, isoxazoyl, thiazolyl, isothiazolyl, furanyl, pyrazolyl, pyrrolyl, tetrazolyl, triazolyl, thienyl, imidazolyl, pyrazinyl, pyrazolyi, indolyl, isoindolyl, pyrazinyl, cinnolinyl, pyridinyl and pyrimidinyl; with the proviso that in any ring formed by NR'R2: (a) there can be no more than one ring oxygen atom; (b) there can be no hydroxy, alkoxy, alkoxymethyl, cyano, amino or alkylamino moiety bonded directly to any nitrogen atom; and (c) no ring carbon that is double bonded to another ring carbon and not part of an aromatic ring system can be bonded to a ring oxygen atom or ring nitrogen atom.
Patent NZ-509730-A (NZ)
Title: Arylpiperazines useful as metalloproteinase inhibitors
Inventor: BARLAAM BERNARD CHRISTOPHE
IPC: A61P29/00
Filed: 1999-08-25
Abstract: An arylpiperazine derivative or a pharmaceutically acceptable salt or ester has the formula (I) wherein: Ring A is a optionally substituted 5-7 membered aliphatic ring; Ring B is a monocyclic or bicyclic alkyl, aryl, aralkyl, heteroaryl or heteroalkyl containing one or more heteroatoms of N, S or O or is biphenyl or ring B can be linked to ring A with alkyl or alkoxy chain linking the 2-position of ring B with the carbon atom a to X2; each R3 is H, halogen, NO2, COOR, CN, CF3, alkyl, S-alkyl, SO-alkyl, SO2-alkyl, alkoxy, aryloxy; n1 is 1 to 3; R is H or alkyl; P is -(CH2)n2-, alkene or alkyne chain or when X2 is carbon P may be Het, -(CH[R6])n3-Het, Het-(CH[R6])n3- or Het-(CH[R6])n3-Het; or P is -CON(R6)-, -N(R6)-CO-, -SO2-N(R6)- or -N(R6)-SO2; Het is CO, S, SO, SO2, NR6 or O; n3 is 1 or 2; X1 and X2 are independently nitrogen or carbon; Y is ûSO2- or ûCO-; Z is -CONHOH, Y is CO and Q is -C(R6)(R7)-, -C(R6)(R7)-CH2, N(R6)- or -N(R6)-CH2- or Z is -CONHOH, Y is SO2 and Q is -C(R6)(R7)- or -C(R6)(R7)-CH2 or Z is -N(OH)-CHO and Q is -C(R6)(R7)-, -C(R6)(R7)-CH2 or -N(R6)-CH2-; R1 is H or optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl or is 2,3,4,5,6-pentafluorophenyl provided that where R1 is substituted by OH, OR4 or -N-Y-R4 Z is not  -N(OH)-CHO; R2 is H, alkyl or together with R1 can form a carbocyclic or heterocyclic spiro 5 to 7 membered ring with the heterocyclic ring containing at least one heteroatom of N, S or O; Q can also be linked to either R1 or R2 to form a 5 to 7 membered alkyl or heteroalkyl ring comprising one or more of O, S or N and R4, R6 and R7 are as defined in the specification. The compounds of formula (I) are useful for treating a disease condition mediated by one or more metalloproteinase enzymes, treating arthritis, atherosclerosis.
Patent NZ-513922-A (NZ)
Title: Composition comprising 5-Ä4-Ä2-(N-methyl-N-2-pyridyl)-amino)ethoxy!benzyl!thiazolidine-2-4-dione
Inventor: PATEL JAI
IPC: A61K31/44
Filed: 2001-09-03
Abstract: A pharmaceutical composition comprising 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolodine-2, 4-dione and a process for it's preparation, characterized in that the composition comprises a unit dose of 2 to 8 mg of the above compound in a pharmaceutically acceptable form and optionally a pharmaceutically acceptable carrier therefore. Also described is the use of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolodine-2, 4-dione in the manufacture of a medicament that is useful in the treatment of diabetes mellitus and conditions associated with diabetes mellitus.
Patent NZ-517147-A (NZ)
Title: Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3- trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity
Inventor: BUTLIN ROGER JOHN
IPC: A61K31/397
Filed: 2000-08-30
Abstract: Described is a compound of formula (I), where: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 and R3 are as defined in the disclosure; R4 is hydrogen or fluoro. Also described is a pharmaceutical composition which comprises a compound of formula (I) as defined above in association with a pharmaceutically acceptable diluent or carrier. The compounds of formula (I) are useful in the treatment of diabetes mellitus, peripheral vascular disease (including intermittent claudication), cardiac failure and certain cardiac myopathies, myocardial ischaemia, cerebral ischemia and reperfusion, muscle weakness, hyperlipidaemias, Alzheimer's disease and/or atherosclerosis.