Patent GB-710105-A (GB)
Title: Detergent and/or bactericidal compositions
Inventor: DAVIES GEORGE EDWARD
IPC: C11D3/26
Filed: 1951-05-31
Abstract: A fungicidal and bactericidal composition having detergent properties comprises a bis-biguanide of the formula:- <FORM:0710105/III/1> wherein A and B stand for aromatic nuclei, the same or different and optionally substituted by one or more hydroxy, halogen, nitro, alkyl or alkoxy radicals, and X stands for a bridging group which is a hydrocarbon or a dialkoxybenzene radical of not more than 15 carbon atoms, preferably in the form of its salt, and for each 100 parts by weight of the bis-biguanide between 50 and 20,000 parts by weight of a substance of known wetting and/or detergent properties.  Preferred bis-biguanides are those in whch A and B are identical and stand for a halogen substituted phenyl radical, and X stands for (CH2)n where n is an integer from 3 to 9.  The composition may be in the form of an aqueous solution, preferably containing at least one part by weight of the bis-biguanide per 100,000 parts by weight of water. Bis-biguanides specified which may be used in the form of their dihydrochlorides or diacetates are:-  1 : 3 - di - (N1 : N11 - p - chlorophenyldiguanido - N5 : N51)-propane  1 : 4 - di - (N1 : N11 - p - chlorophenyldiguanido - N5 : N51)-butane  1 : 5 - di - (N1 : N11 - p - chlorophenyldiguanido - N5 : N51)-pentane  1 : 6 - di - (N1 : N11 - p - chlorophenyldiguanido - N5 : N51)-hexane  and the corresponding p-tolyl, p-anisyl, m-chlorophenyl, 2 : 5-dichlorophenyl, 3 : 4-dichlorophenyl, m-nitrophenyl, phenyl, p-hydroxyphenyl, o-chlorophenyl and 2 : 4-dimethlphenyl compounds  1 : 7 - di - (N1 : N11 - p - chlorophenyldiguanido - N5 : N51)-heptane  1 : 10 - di - (N1 : N11 - p - chlorophenyldiguanido- N5 : N51)-decane  1 : 4 - di - (N1 : N11 - phenyldiguanido - N5 : N51)-benzene and the corresponding p-chlorophenyl compound,  o  : o 1 - di - (N1 : N11 - p - chlorophenyldiguanido-N5 : N51) - 1 : 4 - di - n - propoxybenzene, 4 : 41-di-(N1 : N11 - phenyldiguanido - N5 : N51) - diphenyl - methane and the corresponding p-chlorophenyl compound.  The substances of known wetting and/or detergent properties include inorganic detergents, for example sodium hydroxide, sodium carbonate, borax and the sodium silicates and phosphates; anionic surface active substances, for example salts of long chain fatty acids, of long chain fatty alcohol sulphates, of the higher secondary alkyl sulphates and of the higher alkyl and aryl sulphonates; cationic surface active substances, for example dodecyltetra-decyl- and hexadecyl-pyridinium bromides and chlorides and dodecyl-, tetradecyl- and hexadecyltrimethyl-ammonium bromides and chlorides and long chain alkyldimethylbenzyl-ammonium bromides and chlorides; and non-ionic surface active substances, for example, condensation products of ethylene oxide with alkylphenols, long-chain fatty alcohols, and long-chain fatty acids or their amides. Specification 705,838, [Group IV (b)], is referred to.ALSO:A fungicidal and bactericidal composition having detergent properties comprises a bis-biguanide of the formula: <FORM:0710105/VI/1> wherein A and B stand for aromatic nuclei, the same or different and optionally substituted by one or more hydroxy, halogen, nitro, alkyl or alkoxy radicals, and X stands for a bridging group which is a hydrocarbon or a dialkoxy benzene radical of not more than 15 carbon atoms, preferably in the form of its salt, and for each 100 parts by weight of the bis-biguanide between 50 and 20,000 parts by weight of a substance of known wetting and/or detergent properties.  Preferred bis-biguanides are those in which A and B are identical and stand for a halogen substituted phenyl radical, and X stands for (CH2)n where n is an integer from 3 to 9.  The composition may be in the form of an aqueous solution, preferably containing at least 1 part by weight of the bis-biguanide per 100,000 parts by weight of water. Bis-biguanides specified which may be used in the form of their dihydrochlorides or diacetates are: 1:3 - di - (N1:N11 - p - chlorophenyldiguanido - N5:N15) - propane; 1:4-di-(N1:N11-p-chlorophenyldiguanido - N5: N15)-butane; 1:5 - di - (N1:N11 - p-chlorophenyldiguanido-N5:N15)-pentane; 1:6-di-(N1: N11-p-chlorophenyldiguanido - N5:N15) - hexane; and the corresponding p-tolyl, p-anisyl, m-chlorophenyl, 2:5-dichlorophenyl, 3:4-dichlorophenyl, m-nitrophenyl, phenyl, p-hydroxyphenyl, o-chlorophenyl and 2:4 dimethylhenyl compounds 1:7-di-(N1:N11-p-chlorophenyldiguanido - N5:N15) - heptane; 1:10 - di - (N1:N11-p-chlorophenyldiguanido -N5:N15) - decane; 1:4 - di - (N1: N11 - phenyldiguanido-N5:N15)-benzene and the corresponding p-chlorophenyl compound, di-(N1:N11 - p-chlorophenyldiguanido-N5: N15)-1:4-di-n-propoxybenzene, 4:41-di-(N1:N11-phenyldiguanido -N5:N15)- diphenylmethane and the corresponding p-chlorophenyl compound.  The substances of known wetting and/or detergent properties include inorganic detergents, for example sodium hydroxide, sodium carbonate, borax and the sodium silicates and phosphates; anionic surface active substances, for example salts of long chain fatty acids, of long chain fatty alcohol sulphates, of the higher secondary alkyl sulphates and of the higher alkyl and aryl sulphonates; cationic surface active substances, for example dodecyl-tetra-decyl- and hexadecyl-pyridiumium bromides and chlorides and dodecyl-, tetradecyl- and hexadecyl-trimethyl - ammonium bromide and chlorides and long chain alkyldimethyl-benzyl-ammonium bromides and chlorides; and non-ionic surface active substances for example, condensation products of ethylene oxide with alkylphenols long-chain fatty alcohols, and long-chain fatty acids or their amides. Specification 705,838, [Group IV(b)], is referred to.