Patent SG-11201811311V-A (SG)
Title: Compounds for imaging tau protein aggregates
Inventor: KROTH HEIKO
IPC: A61K51/04
Filed: 2017-07-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 1110101011111 011101 0 011111111111H10011111110111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/015549 Al 25 January 2018 (25.01.2018) WI P0 I P C T (51) International Patent Classification: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 51/04 (2006.01) C07B 59/00 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/EP2017/068509 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 21 July 2017 (21.07.2017) Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a (25) Filing Language: English patent (Rule 4.1700) (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 16180908.2 22 July 2016 (22.07.2016) EP (71) Applicants: AC IMMUNE S.A. [CH/CH]; EPFL Innova- tion Park, Building B, 1015 Lausanne (CH). PIRAMAL IMAGING SA [CH/CH]; Route de l'Ecole 13, 1753 Ma- tran (CH). (72) Inventors: KROTH, Heiko; Chemin de la Chiesaz 1, 1024 Ecublens (CH). MOLETTE, Jerome; 37 La Ru- _ elle Bretigny, 01280 Prevessin Moens (FR). DARMENCY, Vincent; Chemin du Creux du Chable 1, 1172 Bougy-Vil- - lars (CH). SCHIEFERSTEIN, Hanno; Singener Weg 13, 14163 Berlin (DE). MULLER, Andre; Jules-Verne-Str. = = 92, 14089 Berlin (DE). SCHMITT-WILLICH, Heribert; Waldenserstr. 30, 10551 Berlin (DE). BERNDT, Mathias; _ = Reutlinger Str. 5, 12247 Berlin (DE). ODEN, Felix; Osloer Str. 117, 13359 Berlin (DE). GABELLIERI, Emanuele; = Avenue du parc de la Rouvraie 10, 1018 Lausanne (CH). = = (74) Agent: VOSSIUS & PARTNER; SiebertstraBe 3, 81675 — Miinchen (DE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = — SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — 1-1 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, C:7 71- (54) Title: COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES 1 1 in 1 1 in 1-1 N (57) : The present invention relates to novel compounds of the formula (II) that can be em- 0 / \ ployed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates ,-' GO R 1 I such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imag- Il \ ,--\" .. z- N --\" -- - N (II) i ng. i k N N , ,,,,, ,„ ,.. R 2 C