baber/WOPTO huggingface dataset:
Patent CA-3119751-A1 (CA)
Inventor: RYAN JEFFERY B JR
IPC: A61B1/005
Filed: 2019-11-13
Abstract: L'invention concerne un instrument endoscopique (312, 820, 824) qui comprend un tube externe (206) s'étendant d'une extrémité de tube proximale à une extrémité de tube distale, un élément de couple flexible (200) s'étendant à travers le tube externe, un ensemble articulation (400, 500, 600, 700, 828) et un effecteur d'extrémité (450, 550, 650, 750, 824). L'ensemble articulation (400, 500, 600, 700, 828) est relié à l'extrémité de tube distale et comprend une pluralité de segments (404, 408, 504, 604, 704) et au moins un organe de commande (412, 512, 612, 712) s'étendant d'une extrémité de commande proximale à une extrémité de commande distale reliée à la pluralité de segments. L'organe de commande manipule une orientation d'au moins un segment de la pluralité de segments en réponse à la réception d'une entrée de commande au niveau de l'extrémité de commande proximale. L'effecteur d'extrémité (450, 550, 650, 750, 824) est relié à une extrémité distale de l'élément de couple flexible de telle sorte que la manipulation de l'orientation (516, 616, 620) dudit segment commande une orientation de l'effecteur d'extrémité (450, 550, 650, 750, 824) par rapport au tube externe (206), et que la rotation de l'élément de couple flexible (200) commande un angle de rotation de l'effecteur d'extrémité (450, 550, 650, 750, 824) par rapport au tube externe (206).
Patent CA-3120735-A1 (CA)
Inventor: SEBASTIAN ANDRIES D
IPC: A24D1/20
Filed: 2019-11-19
Abstract: La présente invention concerne un élément de source d'aérosol, et un matériau de suremballage conçu pour entourer sensiblement une partie de substrat d'un élément de source d'aérosol. Selon un mode de réalisation donné à titre d'exemple, l'élément de source d'aérosol peut comprendre une partie de substrat qui comprend un matériau de substrat conçu pour générer une substance inhalable primaire lorsque de la chaleur est appliquée sur celui-ci, la partie de substrat définissant une surface externe, et un matériau de suremballage conçu pour entourer sensiblement la surface externe de la partie de substrat, le matériau de suremballage comprenant une pluralité de couches, et au moins l'une des couches du matériau de suremballage contenant un composant de génération d'aérosol.
Patent CA-3120830-A1 (CA)
Title: Systems and methods for obtaining real-time abrasion data
Inventor: MILLOT PATRICK
IPC: B24B51/00
Filed: 2019-11-21
Abstract: The present application relates to systems and methods for obtaining real-time abrasion data. An example system includes a remote sensor that is located remotely from, a grinding tool and a workpiece. The remote sensor is configured to detect vibration and/or noise associated with a grinding operation involving the grinding tool and the workpiece. The system includes communication interface and a controller configured to carry out operations. The operations include receiving, from the remote sensor, at least one of vibration or noise information associated with the grinding tool and the workpiece. The operations also include determining tool-specific information or workpiece-specific information based on the at least one of the vibration or noise information. The operations yet further include transmitting, via the communication interface, the tool-specific information or workpiece-specific information. The system also includes a remote computing device configured to receive the transmitted tool-specific information or workpiece-specific information.
Patent CA-3123067-A1 (CA)
Title: Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes
Inventor: THUM THOMAS
IPC: C12N15/113
Filed: 2009-02-26
Abstract: The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
Patent CA-3125669-A1 (CA)
Title: Adjustable suspension comprising a fluid distribution device
Inventor: ORTUNO AYUSO PABLO
IPC: B62K25/06
Filed: 2020-03-05
Abstract: Suspension réglable (10) comprenant un corps de suspension (16) ayant un fond (20), un piston (22) disposé dans le corps de suspension et comprenant une tête de piston (24), le fond et la tête de piston délimitant une chambre principale (28) à l'intérieur dudit corps de suspension, le piston étant mobile en translation dans le corps de suspension; et un dispositif de distribution de fluide (40) comprenant une entrée principale de fluide (42) configurée pour injecter un fluide dans la suspension et une sortie de fluide (44), le piston pouvant prendre une première position dans laquelle le dispositif de distribution de fluide est configuré pour amener le fluide injecté par l'entrée principale de fluide dans la chambre principale de manière à déployer le piston et une deuxième position dans laquelle le dispositif de distribution de fluide est configuré pour guider le fluide injecté par l'entrée principale de fluide vers la sortie de fluide afin d'évacuer le fluide hors de la suspension.
Patent CA-3125983-A1 (CA)
Inventor: BEJJANKI SANTHOSH KUMAR
IPC: H04L12/18
Filed: 2020-01-06
Abstract: Methods and systems for augmenting communications using input data from mobile devices are described herein. A computing device may establish a connection with a mobile device having one or more input devices. The computing device may display a barcode that, when scanned by a mobile device, causes the mobile device to access a web page. The web page may be configured to cause the mobile device to transmit, e.g., via a web browser executing on the mobile device and to the computing device, input data from the input devices. The input data may be used by the computing device to replicate a physical input device connected to the computing device. The computing device may transmit the input data to a different computing device.
Patent CA-3130748-A1 (CA)
Title: Systems for simulating joining operations using mobile devices
Inventor: MARQUINEZ PEDRO
IPC: G09B19/24
Filed: 2020-02-19
Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearers eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.
Patent CA-3130969-A1 (CA)
Title: Intelligent current transformer
Inventor: YAO XINGDONG
IPC: H04L12/40
Filed: 2021-09-16
Abstract: Disclosed is an intelligent current transformer. The intelligent current transformer includes a transformer housing structure, a secondary wiring terminal, a 485 bus wiring terminal, a mounting base plate, a terminal cover, a circuit board, a main magnetic core coil, and an auxiliary magnetic core coil. The main magnetic core coil, the auxiliary magnetic core coil and the circuit board are mounted inside the transformer housing structure and are potted with epoxy. The secondary wiring terminal and the 485 bus wiring terminal are secured on the transformer housing structure by hot melting. The circuit board is connected to the 485 bus wiring terminal and an outlet line of the auxiliary magnetic core coil, and an outlet line of the main magnetic core coil is connected to the secondary wiring terminal.
Patent CA-3132012-A1 (CA)
Title: Aeronef comportant un systeme de propulsion electrique hybride a accumulateur electrique situe dans les ailes
Inventor: BECKER FRANK
IPC: B64D31/00
Filed: 2019-12-10
Abstract: Aéronef comprenant un fuselage définissant un axe longitudinal entre une extrémité avant et une extrémité arrière. Au moins un profil s'étend latéralement à partir du fuselage définissant un axe de profil. Un système électrique comprend un accumulateur électrique. L'accumulateur électrique est positionné à l'intérieur du profil.
Patent CA-3136088-A1 (CA)
Inventor: BURGER MATTHEW T
IPC: A61K47/68
Filed: 2020-05-19
Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
Patent CA-3139352-A1 (CA)
Title: Identification of candidate signs indicative of an ntrk oncogenic fusion
Inventor: SCHMITZ ARNDT
IPC: G16H30/40
Filed: 2020-04-28
Abstract: The present invention relates to the identification of one or more candidate signs indicative of an NTRK oncogenic fusion within patient data. Subject matter of the present invention are a computer- implemented method, a system, and a non-transitory computer-readable storage medium for determining a probability value from patient data associated with a subject patient, the probability value indicating the probability of the subject patient suffering from cancer caused by a mutation of a neurotrophic receptor tyrosine kinase (NTRK) gene.
Patent CA-3139789-A1 (CA)
Inventor: PEDERSEN THOMAS
IPC: E04D1/34
Filed: 2020-05-07
Abstract: La présente invention concerne un système (10) pour monter des tuiles de toit en verre (12) sur une construction de toit. Le système (10) comprend un liteau de toit (11), un support en forme de S (1) définissant une première partie en forme de U (2) et une seconde partie en forme de U (3), une plaque de scellement étanche (4) et deux tuiles de toit en verre (12) agencées côte à côte le long d'une première direction longitudinale (13) définie par le liteau de toit (11). La première partie en forme de U (2) du support (1) est fixée sur le liteau de toit (11) et maintenue par rapport à celui-ci uniquement par frottement et gravité. Une partie d'extrémité de la plaque de scellement étanche (4) et une partie d'extrémité inférieure de chacune des tuiles de toit en verre (12) s'emboîtent parfaitement dans la seconde partie en forme de U (3) du support (1), de telle sorte que le support (1) et la plaque de scellement étanche (4) chevauchent les parties d'extrémité inférieures respectives des deux tuiles de toit en verre (12) lorsque les tuiles de toit en verre (12) sont agencées côte à côte le long de la première direction longitudinale (13), et de telle sorte que la plaque de scellement étanche (4) et les deux tuiles de toit en verre (12) sont maintenues par rapport au support (1) uniquement par frottement et gravité. Ainsi, les tuiles de toit en verre (12) peuvent être montées sur la construction de toit d'une manière facile et rapide sans utiliser de moyens ou d'outils de fixation.
Patent CA-3142341-A1 (CA)
Title: Roofing shingles and palleted pluralities thereof
Inventor: SHRINIVASA RAKSHITH
IPC: E04D1/14
Filed: 2021-12-15
Abstract: The present disclosure relates to roofing shingles and palleted pluralities thereof that have a reduced susceptibility to damage during shipment.
Patent CA-3143325-A1 (CA)
Title: Tip dressing installation system and method
Inventor: GRAVEL SYLVAIN
IPC: B23K9/32
Filed: 2020-06-18
Abstract: A tip dressing system includes a tip dressing machine having a gear unit. A holder is installed in the gear unit, and a cutter is installed on the holder. The holder may include mechanical structure corresponding to the gear unit that prevents the holder from being installed incorrectly and further prevents a holder that does not match the machine from being installed in the gear unit. The cutter may include mechanical structure corresponding to the holder to prevents the cutter from being installed incorrectly and further prevents a cutter that does not match the holder from being attached to the holder. The machine, holder, and cutter may include indicators configured for being scanned by a scanning device, and a controller may determine whether the scanned components match.
Patent CA-3143730-A1 (CA)
Title: Valves and delivery apparatuses equipped with optic fiber sensors
Inventor: DVORSKY ANATOLY
IPC: A61F2/24
Filed: 2020-10-27
Abstract: The present invention relates to devices and methods for measuring expansion diameter, radial force exerted against surrounding tissue, and pressure recovery across prosthetic heart valves, during valve implantation procedures.
Patent CA-3144038-A1 (CA)
Title: Recrystallisation of 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) in methyl tert.-butyl ether (mtbe) and less than 5 wt% of an aliphatic anti-solvent
Inventor: PATRICK LEONARD GERARD FRANCIS
IPC: C07D209/16
Filed: 2020-06-19
Abstract: A method of purifying 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is provided which comprises dissolving crude 5-MeO-DMT in a solvent at a temperature above room temperature, cooling the obtained solution to a temperature below room temperature to precipitate solid 5-MeO- DMT, separating the solid 5-MeO-DMT from the remaining solution and removing solvent from the crystalline 5-MeO-DMT. In the method, the solvent comprises one or more ethers and less than 5 wt% anti-solvent.
Patent CA-3145039-A1 (CA)
Title: Disinfecting cap with pressure seal capability
Inventor: JIANG CHANG
IPC: A61M39/16
Filed: 2020-08-05
Abstract: A cap is described for connection to a needleless connector having an open lumen, the cap includes a housing having a top wall and sidewall forming a first cavity, an insert, an absorbent reservoir material and a sealing foam. The insert includes an inner thread on an inner surface, the inner thread being sufficient to interlock with a mating feature of a female needleless connector. The inner surface of the insert defines a second cavity. The protrusion/insert includes an outer thread on an outer surface, the outer thread being sufficient to interlock with a mating feature of a male needleless connector. The second cavity configured to define a chamber to contain an absorbent reservoir material, a sealing foam and disinfectant or antimicrobial agent.
Patent CA-3145063-A1 (CA)
Title: Systems and methods for ski lift operations
Inventor: QUEEN BRYAN SCOTT
IPC: G06V20/40
Filed: 2020-06-23
Abstract: Systems and methods for improved operations of ski lifts increase skier safety at on-boarding and off-boarding locations by providing an always-on, always-alert system that "watches" these locations, identifies developing problem situations, and initiates mitigation actions. One or more video cameras feed live video to a video processing module. The video processing module feeds resulting sequences of images to an artificial intelligence (AI) engine. The AI engine makes an inference regarding existence of a potential problem situation based on the sequence of images. This inference is fed to an inference processing module, which determines if the inference processing module should send an alert or interact with the lift motor controller to slow or stop the lift.
Patent CA-3146463-A1 (CA)
Title: Liposomes de ciblage contenant un medicament
Inventor: KLEIN JOSEPH YESHAYAHU
IPC: A61K9/127
Filed: 2020-08-31
Abstract: L'invention concerne de nouveaux peptides de ciblage modifiés pouvant être incorporés dans des liposomes. L'invention concerne également des liposomes contenant ces peptides de ciblage modifiés. Les liposomes comprennent de préférence une bicouche à base de lipides et au moins un médicament. L'invention concerne également des procédés de fabrication de ces peptides de ciblage modifiés, lesdits liposomes, ainsi que des méthodes de traitement de maladies du système nerveux central (SNC) au moyen de ces liposomes.
Patent CA-3149414-A1 (CA)
Title: Non-pusher dry gas seal with sealing elastomer and systems utilizing same
Inventor: WASSER JAMES R
IPC: F16J15/00
Filed: 2020-09-04
Abstract: A seal that can be used alone or as a containment seal for another seal includes a primary ring (36) and a mating ring (30), the primary ring being axially shiftable relative to a rotating shaft (12) and the mating ring being axially fixable relative to the rotating shaft, a biasing mechanism (500) that urges the primary ring toward the mating ring, and an annular flexible sealing membrane (100). The membrane includes a flange portion (102) disposed at least partially between the biasing mechanism and the primary ring, a coaxial portion (104) that is axially fixable relative to the shaft, and a flexible connection portion (106) positioned within a radially inward extent of the flange portion and connecting the flange portion to the coaxial portion. At least one of the mating ring and the primary ring includes grooves formed on a face thereof that cause the formation of a gas film to develop between the primary ring and the mating ring that keeps the primary ring and the mating ring from contacting each other in operation.
Patent CA-3149563-A1 (CA)
Title: A parallel-kinematic machine with versatile tool orientation
Inventor: BROGARDH TORGNY
IPC: B25J9/00
Filed: 2020-08-17
Abstract: A parallel kinematic machine, PKM, comprising: a support platform (17a), a first support linkage (SL1); a second support linkage (SL2) and a third support linkage (SL3), wherein the first support linkage (SL1), the second support linkage (SL2) and the third support linkage (SL3) together comprises at least five support links (8, 9, 10, 11, 12, 13). The PKM further comprises: a tool base (140) comprising a shaft joint (24, 40, 41, 200, 202, 262a, 262b), a tool base shaft (19) and a tool platform (17b). The tool base shaft (19) is connected to the support platform (17a) via the shaft joint (24, 40, 41, 200, 202, 262a, 262b), and wherein the tool platform (17b) and the tool base shaft (19) are rigidly connected. The PKM also comprises one or more tool linkages (TL1, TL2, TL3) each comprising a tool link (26, 31; 29, 32; 38) connected at one end via a tool base joint (25, 28, 37) to the tool base (140), and at the other end connected via a tool carriage joint (27, 30, 39) to a carriage arranged for movement along a path; and wherein each tool linkage (TL1, TL2, TL3) is configured to rotate the tool base shaft (19) around at least one axis relative the support platform (17), by transferring a movement of the respective tool linkage (TL1, TL2, TL3) to the tool base shaft (19).
Patent CA-3149898-A1 (CA)
Title: Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
Inventor: LOUMAYE ERNEST
IPC: A61K31/40
Filed: 2020-08-31
Abstract: The disclosure provides compositions and methods for the use of oxytocin antagonists, such as substituted pyrrolidin-3-one oxime derivatives of formula (I), among other compounds, in the treatment of subjects undergoing embryo transfer therapy. The compositions and methods of the disclosure can be used to dose subjects with oxytocin antagonists, including (3Z,5S)-5-(hydroxymethyl)-l-[(2'- methyl-l,l'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime, among others, so as to improve endometrial receptivity and reduce the likelihood of embryo implantation failure and miscarriage following, for example, in vitro fertilization (IVF) and intra cytoplasmic sperm injection (ICSI) embryo transfer procedures. (Formula I)
Patent CA-3150851-A1 (CA)
Inventor: KALMETA MARGARET V
IPC: A61L26/00
Filed: 2020-08-11
Abstract: La présente invention concerne des compositions qui peuvent être administrées à un sujet ayant un tissu endommagé, par exemple une plaie. Les compositions sont souvent administrées en combinaison avec l'administration d'énergie (par exemple, de l'énergie laser, de la lumière provenant d'une diode électroluminescente, de l'énergie radiofréquence (RF), de l'énergie fréquence audio, etc.) à partir d'un dispositif et/ou d'un système de génération d'énergie vers le site affecté. Les compositions, les systèmes, les dispositifs et les procédés de la présente invention ont été découverts pour induire une cicatrisation de plaie et une régénération tissulaire.
Patent CA-3151988-A1 (CA)
Title: Compositions de nanoparticules pour la therapie genique
Inventor: WANG WENXIN
IPC: C12N15/88
Filed: 2020-09-22
Abstract: L'invention concerne une composition nanoparticulaire comprenant un système de ribonucléoprotéine d'édition de gène complexé à l'intérieur d'un polymère cationique. Le polymère cationique peut être un polymère hyperramifié à base de poly-bêta-aminoester, en particulier un polymère hyperramifié à 4 branches. Le système de ribonucléoprotéine d'édition de gène peut être un système d'édition de gène CRISPR-Cas9 configuré pour exciser une mutation ou un exon dans un gène, remplacer une mutation dans un gène ou produire un knock-down ou un knock-out d'un gène, et en particulier configuré pour exciser l'exon 80 du gène COL7A1 qui code pour la protéine de collagène VII.
Patent CA-3152220-A1 (CA)
Inventor: PINOIE VANJA
IPC: A61K47/26
Filed: 2020-09-04
Abstract: The present disclosure relates to a sterile medical product for parenteral nutrition comprising a polymeric container having at least a first and a second chamber which are separated by a non-permanent peel seal, wherein the first chamber contains a composition of amino acids and optional- ly electrolytes, and wherein the second chamber contains a dextrose solution, and wherein the product is characterized by a high protein (nitrogen) content per volume. The reconstituted solution is configured to be administered periph- erally or centrally for the treatment of patients suffering from malnutrition and/or having a need for increased uptake of amino acids.
Patent CA-3154113-A1 (CA)
Inventor: RUBIO PEDRO
IPC: A23K10/12
Filed: 2020-09-11
Abstract: Fermented milk products can provide multiple benefits. However, it was commonly believed that fermented milk products are not suitable for the administration to canids as e.g. dogs can be intolerant to lactose. The present invention provides fermented milk products for administration to canids.
Patent CA-3154908-A1 (CA)
Inventor: BHAT SREENIVAS S
IPC: A61K9/16
Filed: 2020-10-20
Abstract: La présente invention concerne des compositions pharmaceutiques (par exemple, des formulations posologiques orales) comprenant du (S)-2-(2,6-dioxopipéridine-3-yl)-4-((2-fluoro-4-((3-morpholinoazétidine-1-yl)méthyl)benzyl)amino)isoindoline-1,3-dione ou un énantiomère, un mélange d'énantiomères, un tautomère, un isotopologue ou un sel pharmaceutiquement acceptable correspondant et un support ou un diluant. L'invention concerne également des procédés de préparation et des méthodes d'utilisation des compositions pharmaceutiques.