baber/WOPTO huggingface dataset:
Patent EP-4196572-A1 (EP)
Title: Immunosuppressant-resistant t-cells for adoptive immunotherapy
Inventor: AMINI LEILA
IPC: A61P31/12
Filed: 2021-08-13
Abstract: The present invention provides to the field of cell therapy, in particular, to adoptive T cell or NK cell therapy. It provides a human immunophilin knockout cell that is a T cell or NK cell, wherein the immunophilin is FKBP12 or cyclophilin A, or a cell population of such cells. The cell is resistant to the action of the immunosuppressant Tacrolimus and/or cyclosporine A. It is obtainable by CRISPR/Cas, e.g., CRISPR/Cas9-mediated knockout of the immunophilin or a derivate technology. The cell can be, e.g., a virus-specific cell, e.g., specific for an antigen from any of CMV, EBV, BKV, HPV, ADV, influenza virus, or SARS-CoV-2. It may also be a regulatory T cell. The invention also provides a method for preparing the human immunophilin knockout T cell or NK cell of the invention, pharmaceutical compositions or kits comprising said cells, pharmaceutical compositions or kits for use in in treatment or prevention of an infection with a virus or another pathogen or for use in treatment of cancer, or for use in balancing an unwanted immune response, e.g., in the context of a condition selected from the group comprising autoimmunity, allergy, a transplantation and bystander activation. Methods of treatment are also disclosed.
Patent EP-4120820-A1 (EP)
Inventor: CHADEAYNE ANDREW R
IPC: A01G2/10
Filed: 2021-03-18
Abstract: The disclosure relates to crystalline psilacetin derivatives, compositions containing those crystalline derivatives, and methods of treatment using them. The crystalline psilacetin derivatives include crystalline 4-acetoxy- N -methyl- N -ethyltryptammonium (4-AcO-MET) hydrofumarate ("crystalline 4-AcO-MET hydrofumarate"), crystalline 4-acetoxy- N -methyl- N -allyltryptammonium (4-AcO-MALT) hydrofumarate ("crystalline 4-AcO-MALT hydrofumarate"), and crystalline 4-acetoxy- N , N -diallyltryptammonium (4-AcO-DALT) fumarate fumaric acid ("crystalline 4-AcO-DALT fumarate fumaric acid").
Patent EP-4218256-A1 (EP)
Title: Embout auriculaire auto-obturant pour écouteurs intra-auriculaires
Inventor: KHONSARIPOUR OMID
IPC: H04R1/10
Filed: 2021-08-31
Abstract: Dans certains modes de réalisation, un appareil comprend un élément de génération audio; un manchon comprenant un canal longitudinal, une surface externe du manchon comprenant au moins une première partie qui est extensible dans une dimension en coupe transversale dans au moins une direction; et un insert rigide configuré pour être inséré dans le canal longitudinal. Au moins la première partie de la surface extérieure du manchon se dilate dans la ou les directions lorsque l'insert rigide est inséré dans le canal longitudinal.
Patent EP-4113456-A1 (EP)
Inventor: UNNO Kyohei
IPC: G06T19/20
Filed: 2021-02-19
Abstract: A point-cloud decoding device 200 according to the present invention includes: a geometry information decoding unit 2010 configured to decode a flag that controls whether to apply "Implicit QtBt" or not; and an attribute-information decoding unit 2060 configured to decode a flag that controls whether to apply "scalable lifting" or not; wherein, a restriction is set not to apply the "scalable lifting" when the "Implicit QtBt" is applied.
Patent EP-4128050-A1 (EP)
Inventor: TAMIR MICHAEL
IPC: G06N3/00
Filed: 2021-03-10
Abstract: A method and system for improving a three-dimensional (3D) representation of objects using semantic data. The method comprises receiving an input data generated in response to captured video in a filming area; setting at least one parameter for each region in the input data; and generating a 3D representation based in part on the at least one parameter and semantic data associated with the input data.
Patent EP-4132559-A1 (EP)
Inventor: BHATTACHARYA BABWAH M MOSHMI
IPC: A61P5/48
Filed: 2021-04-08
Abstract: Le récepteur de la kisspeptine 1 (KISS1R) est un récepteur couplé à la protéine G qui se lie à l'hormone peptidique kisspeptine 54-AA (métastine). TAK-448 est un agoniste puissant du récepteur de la kisspeptine 1 (KISS1R, ou GPR54). La kisspeptine et le KISS1R dans le cerveau jouent des rôles clés dans la reproduction des mammifères en raison de leur implication dans l'apparition de la puberté et de la commande de l'axe hypothalamo-hypophyso-gonadique. Cette spécification concerne des résultats qui impliquent la voie de la kisspeptine/Kiss1R périphérique dans la pathogenèse de la stéatose hépatique non alcoolique et fournissent un procédé de réduction de la graisse dans le foie.
Patent EP-4132596-A1 (EP)
Inventor: ELROD SCOTT A
IPC: A61L9/015
Filed: 2021-04-09
Abstract: Devices, systems, and methods to treat an environment. The device includes a scent control material source. The device can also include a dehumidifier, humidifier, and one or more fans. The scent control material device is configured to output a scent control material (e.g., an oxidant) into the environment to reduce pathogens, dispose of scent molecules and their sources, and otherwise treat the environment. The device can include a controller communicatively coupled to the scent control material source, dehumidifier, humidifier, and one or more fans. The controller can implement operational programs dictating at least one output of the device. The device can also function in a cyclical or periodic mode in which an output of the device can be varied to more effectively treat the environment. In examples, the controller can operate in conjunction with a remote control to regulate output parameters of the device.
Patent EP-4211370-A1 (EP)
Inventor: SOATTI PIERO
IPC: F16H61/12
Filed: 2021-09-09
Abstract: La présente invention concerne un procédé de détermination d'une configuration de changement de vitesse opérationnel d'un mécanisme d'entraînement (1) d'une boîte de vitesses (G) d'un véhicule du type à selle (4). En particulier, ce procédé est appliqué à un mécanisme d'entraînement (1) comprenant un levier de changement de vitesse (12) et un dispositif de changement de vitesse rapide (5) qui raccorde, directement ou indirectement, le levier à la boîte de vitesses, ce dispositif comprenant une tige (10) et des premiers moyens de capteur (SM0, SM1-SM2) qui détectent la variation de l'état de tension de ladite tige (10) suite à un changement de vitesse. Le procédé selon l'invention prévoit l'acquisition d'un premier signal (S1) généré par lesdits premiers moyens de capteur et la détermination, sur la base dudit premier signal, si oui ou non la tige est dans un état de tension de traction ou dans un état de tension de compression. Le procédé prévoit également l'acquisition d'au moins un second signal (S2) généré par des seconds moyens de capteurs (SM3) et la détermination, sur la base de ce second signal (S2), de la vitesse en prise suite audit changement de vitesse et/ou à la direction dudit changement de vitesse. Enfin, le procédé comprend la détermination de la configuration de changement de vitesse opérationnel du mécanisme d'entraînement sur la base de l'état de tension déterminé dans l'étape B) et la vitesse en prise et/ou en fonction de la direction dudit changement de vitesse déterminé dans l'étape D).
Patent EP-4241018-A1 (EP)
Inventor: GASPARIN SZABOLCZ
IPC: F21V21/02
Filed: 2021-10-26
Abstract: This invention relates to a modular and removable integration technique for a luminaire (100) on an adaptor plate (201) with a general area lighting rail system (202). The luminaire (100) comprises, a mounting system (200), a lighting device (300), and a mounting device (400). The mounting system (200) comprises an adaptor plate (201) that can be attached to a rail system (202). The lighting device (300) comprises a shaft (301) that is 5 configured to have a lamp (302) on a first end and a flange (303) on a second end. The mounting device (400) comprises at least a pair of interface plugs (401, 402). The pair of interface plugs (401, 402) is configured to be attached together to form an inner perimeter (403) around a hollow space and the inner perimeter (403) can embrace the second end of the shaft (301) that is received through an opening (203) of the adaptor plate (201). The inner 10 perimeter (403) is substantially the same or larger than an outer perimeter of the shaft, but smaller than the flange (303). The opening (203) of the adaptor plater (201) is bigger than the flange (303), and smaller than the mounting device (400) when the pair of the interface plugs (401, 402) are attached together.
Patent EP-4149431-A1 (EP)
Inventor: DE JUAN EUGENE
IPC: A61K9/14
Filed: 2021-05-12
Abstract: Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20 °C.
Patent EP-4237815-A1 (EP)
Title: Prédiction d'usure de train de roulement à l'aide d'un modèle d'apprentissage automatique
Inventor: ZHANG LI
IPC: G01M13/00
Filed: 2021-10-04
Abstract: Un système peut comprendre un dispositif. Le dispositif peut être configuré pour recevoir, en provenance d'un ou de plusieurs dispositifs de capteur de la machine, des données de capteur associées à l'usure d'un ou de plusieurs composants d'un train de roulement de la machine ; et prédire, à l'aide d'un modèle d'apprentissage automatique et des données de capteur, une quantité d'usure du ou des composants sur la base d'un taux d'usure du ou des composants. Le modèle d'apprentissage automatique est entraîné, à l'aide de données d'entraînement, pour prédire le taux d'usure du ou des composants. Les données d'entraînement comprennent au moins deux éléments parmi : des données de capteur historiques, des données d'inspection historiques, ou des données de simulation, d'un modèle de simulation, provenant d'un ou de plusieurs troisièmes dispositifs. Le dispositif peut effectuer une action sur la base de la quantité d'usure.
Patent EP-4237840-A1 (EP)
Inventor: LEVEILLE WADE P
IPC: G01N30/60
Filed: 2021-10-28
Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.
Patent EP-4238058-A1 (EP)
Inventor: LOVEGROVE STEVEN JOHN
IPC: G06T7/73
Filed: 2021-10-13
Abstract: In one embodiment, a method includes instructing, at a first time, a camera with multiple pixel sensors to capture a first image of an environment comprising an object to determine a first object pose of the object. Based on the first object pose, the method determines a predicted object pose of the object at a second time. The method determines a predicted camera pose of the camera at the second time. The method generates pixel-activation instructions based on a projection of a 3D model of the object having the predicted object pose onto a virtual image plane associated with the predicted camera pose. The method instructs, at the second time, the camera to use a subset of the plurality of pixel sensors to capture a second image of the environment according to the pixel-activation instructions. The method determines, based on the second image, a second object pose of the object.
Patent EP-4237565-A1 (EP)
Inventor: MILLAY DOUGLAS
IPC: C12N15/86
Filed: 2021-10-30
Abstract: Some embodiments of the invention include pseudotyped particles (e.g., pseudo typed exosomes, pseudotyped VSV, and pseudo typed lentiviruses) and modified cells. Other embodiments of the invention include compositions (e.g., pharmaceutical compositions) of pseudotyped particles (e.g., pseudotyped exosomes, pseudotyped VSV, and pseudotyped lentiviruses) and modified cells. Certain embodiments of the invention include methods of making pseudotyped particles (e.g., pseudotyped exosomes, pseudotyped VSV, and pseudotyped lentiviruses) and modified cells. Other embodiments of the invention include methods of administering pseudotyped particles (e.g., pseudotyped exosomes, pseudotyped VSV, and pseudotyped lentiviruses). Further embodiments of the invention include methods of administering pseudotyped particles (e.g., pseudotyped exosomes, pseudotyped VSV, and pseudotyped lentiviruses) to treat diseases (e.g., muscular dystrophy). Additional embodiments of the invention are also discussed herein.
Patent EP-4285035-A1 (EP)
Inventor: VOREC JOZEF
IPC: F16C19/46
Filed: 2021-12-01
Abstract: The invention relates to a rolling bearing arrangement, comprising a rolling bearing having an inner ring, an outer ring, rolling elements and a cage (10), wherein the inner ring has an inner ring raceway and the outer ring has an outer ring raceway, wherein the rolling elements are spaced apart from one another between the inner ring and the outer ring so as to be rotatable in the cage, wherein the rolling elements roll on the inner ring raceway and the outer ring raceway, wherein the rolling elements are designed as rolling element rollers and the cage is designed as a pocket cage which has two coaxial pocket cage rings (11) which are connected to a plurality of pocket cage axial separating strips (12) to form pocket openings for receiving the rolling elements, wherein the pocket cage axial separating strips have a substantially flat contact surface (14) on the side facing radially inwards, the contact surface having, in each case, at least two grooves (15) which extend in the circumferential direction of the pocket cage, wherein the central contact surface (16), which is formed between the two grooves, has an axial extension which corresponds to between 3% and 40% of the axial extension of one of the pocket cage axial separating strips.
Patent EP-4169389-A1 (EP)
Title: Wheat roasting profile
Inventor: SUZUKI TOMONORI
IPC: A23L7/10
Filed: 2021-06-18
Abstract: An object of the present invention is to provide a novel method for roasting barley. The present invention provides a method for roasting barley, including a step of roasting barley, wherein in the roasting step, the barley is roasted such that a lightness change rate expressed by formula 1 is less than -0.04.[Formula 1] Lightnesschangerate=LT2−LT1T2−T1wherein T1 and T2: time (seconds) after starting roasting, provided that T2>T1≥0;L<sub>T1</sub>: a lightness ratio of the barley at T1 (lightness of the barley at T1/lightness of the barley before roasting); andL<sub>T2</sub>: a lightness ratio of the barley at T2 (lightness of the barley at T2/lightness of the barley before roasting).
Patent EP-4169247-A1 (EP)
Inventor: TROJE NIKOLAUS
IPC: H04N13/366
Filed: 2021-06-22
Abstract: There is provided a system and method for reinstating directionality of onscreen displays of three-dimensional (3D) imagery using sensor data capturing eye location of a user. The method can include: receiving the sensor data capturing the eye location of the user; tracking the location of the eyes of the user relative to a screen using the captured sensor data; determining an updated rendering of the onscreen imagery using off-axis projective geometry based on the tracked location of the eyes of the user to simulate an angled viewpoint of the onscreen imagery from the perspective of the location of the user; and outputting the updated rendering of the onscreen imagery on a display screen.
Patent EP-4170330-A1 (EP)
Inventor: OTAKE YOSHIE
IPC: G01N23/22
Filed: 2021-06-18
Abstract: A cable inspection device (10) non-destructively inspects a cable (5) used for supporting a bridge. The cable inspection device (10) includes a neutron source (21) and a neutron detection device (22). The neutron source (21) emits neutrons to the cable (5). The neutron detection device (22) includes a detection surface (23) arranged outside the cable (5), and detects target neutrons and measures the number of the detected target neutrons when neutrons are emitted to the cable (5). The target neutrons are among the neutrons released from the cable (5) and incident on the detection surface (23), and each have an energy equal to or lower than a predetermined value that is lower than an energy of a fast neutron.
Patent EP-4252400-A1 (EP)
Title: Bit index explicit replication traffic engineering fast reroute
Inventor: CHEN HUAIMO
IPC: H04L45/28
Filed: 2021-12-01
Abstract: A method implemented by a network node in a Bit Index Explicit Replication Traffic Engineering (BIER-TE) domain is disclosed. The method includes generating a fast reroute bit index forwarding table (FRR-BIFT) containing a backup path having one or more bit positions from the network node to each next hop of a neighbor node of the network node, and sending a packet to the next hop of the neighbor node in accordance with the one or more bit positions in the backup path of the FRR-BIFT when the neighbor node has failed.
Patent EP-4172883-A1 (EP)
Title: Systems and methods for coupling between qubits
Inventor: MOLAVI REZA
IPC: B82Y10/00
Filed: 2021-06-29
Abstract: A superconducting integrated circuit has a first superconducting device with a first superconducting loop, where the first superconducting loop has a first superconducting trace in a first layer of the superconducting integrated circuit, and a second superconducting device with a second superconducting loop, where the second superconducting loop has a second superconducting trace in a second layer. The first superconducting loop crosses the second superconducting loop in a crossing region. At least a portion of each of the first and the second superconducting trace inside the crossing region is narrower than at least a portion of each of the traces outside the crossing region, and follows a respective circuitous path which is inductively proximate to at least a portion of the other path.
Patent EP-4260461-A1 (EP)
Inventor: BECK MATTHEW
IPC: H03K3/38
Filed: 2021-12-08
Abstract: A method of generating an output signal based on a single flux quantum (SFQ) pulse includes receiving the SFQ pulse and splitting it into a first path and a second path. The split SFQ pulse of the second path is stored in a latch. A second splitting of the split SFQ pulse of the first path is provided to provide a first output signal and a second output signal of the first path. The second output signal is delayed by a delay Josephson transmission line (JTL). An output of the delay JTL is provided as a clock input to the latch. The first output of the first path is recombined with an output of the latch to provide an output signal.
Patent EP-4263682-A1 (EP)
Inventor: DESIO GLENN P
IPC: C08J5/24
Filed: 2021-12-16
Abstract: L'invention concerne des stratifiés composites multicouches comprenant au moins deux couches, chaque couche comprenant des fibres de renforcement continues et une matrice polymère, ladite matrice polymère comprenant au moins un polymère thermoplastique choisi dans le groupe constitué par les polyamides aliphatiques, les polyamides semi-aromatiques, les polyarylèneéthercétones, les polyphénylènesulfides et le polymère cristallin liquide, et au moins un agent antichoc. L'invention concerne en outre des articles incorporant le stratifié composite thermoplastique.
Patent EP-4238266-A1 (EP)
Title: Enabling dynamic switching between multiple transmission reception points and single transmission reception points physical uplink control channel schemes
Inventor: DEGHEL MATHA
IPC: H04L5/00
Filed: 2021-12-20
Abstract: Systems, methods, apparatuses, and/or computer program products for dynamically switching between or determining whether to apply single-TRP mode and/or multiple-TRP mode are provided. One method may include receiving, at a user equipment, configuration information indicating that multi-transmission reception point (TRP) physical uplink control channel (PUCCH) scheme could be applicable, and determining, at the user equipment, whether to apply the multi-TRP PUCCH scheme or a single-TRP PUCCH scheme for an uplink control information (UCI) transmission on a determined PUCCH resource.
Patent EP-4267886-A1 (EP)
Inventor: SHEPPARD LUKE MICHAEL
IPC: F24D3/08
Filed: 2021-12-23
Abstract: A hydraulic unit is for use in a multi zone heating system. The hydraulic unit comprises: a variable output pump; a plurality of independently controllable valves, each valve being associated with one heating zone; and at least one temperature sensor. Each heating zone receives a heated water supply from a common heat source via the pump. The heating system includes a controller comprising a processor which receives signals from the at least one temperature sensor which processes the signals in accordance with control software. Command signals are sent to the pump and the plurality of independently controllable valves, to vary the flow rate of water from the common heat source to each of the heating zones independently one to another. Remote fault diagnosis and control is also provided.
Patent EP-4259121-A1 (EP)
Inventor: PHARES KENNETH ROBERT
IPC: A61K31/216
Filed: 2021-12-13
Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Patent EP-4268003-A1 (EP)
Inventor: SCHÖNLE ANDREAS
IPC: G02B21/00
Filed: 2021-12-21
Abstract: The invention relates to a light microscopy method, comprising illuminating a sample (S) comprising fluorescent dye molecules (F) by an excitation light beam (14), illuminating the sample (S) by a first impeding light beam (15), generating an intensity distribution (D) of the impeding light (I) with at least one local minimum (M), providing additional impeding light (I) in an area (A) overlapping with the local minimum (M), obtaining a first fluorescence signal from the area (A) in the absence of the additional impeding light (I), and obtaining a second fluorescence signal from the area (A) in the presence of the additional impeding light (I), and correcting the first fluorescence signal by the second fluorescence signal, wherein at each point of the intensity distribution (D) at which the impeding light (I) has a light intensity (II) greater than a saturation intensity of the impeding light (I), the light intensity (II) of the impeding light (I) differs by 20 % or less between the intensity distribution (D) in the presence of the additional impeding light (I) and the intensity distribution (D) in the absence of the additional impeding light (I). The invention further relates to a light microcopy device (1), particularly for implementing the method according to the invention.