Patent SG-11201811590R-A (SG)
Title: [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
Inventor: DYCKMAN ALARIC J
IPC: C07D471/04
Filed: 2017-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property :::` , Organization MD 1101111 II DOI HIM 011101 0 011111 HH11111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....•\"\"- WO 2018/005586 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: dra Industrial Area IV Phase, Jigani Link Road, Bommasan- C07D 471/04 (2006.01) A61K 31/437 (2006.01) dra, Karnataka, Bangalore 560 099 (IN). HEGDE, Subra- (21) International Application Number: maya; c/o Syngene International Limited, Biocon Special Economic Zone, Biocon Park, Plot No. 2&3, Bommasan- PCT/US2017/039633 dra Industrial Area IV Phase, Jigani Link Road, Bommasan- (22) International Filing Date: dra, Karnataka, Bangalore 560 099 (IN). RAMACHAN- 28 June 2017 (28.06.2017) DRA, Anupama; c/o Syngene International Limited, Bio- con Special Economic Zone, Biocon Park, Plot No. 2&3, (25) Filing Language: English Bommasandra Industrial Area IV Phase, Jigani Link Road, (26) Publication Language: English Bommasandra, Karnataka, Bangalore 560 099 (IN). (30) Priority Data: (74) Agent: VANATTEN, Mary K. et al.; Bristol-Myers 201611022328 29 June 2016 (29.06.2016) IN Squibb Company, Route 206 and Province Line Road, 15/635,055 27 June 2017 (27.06.2017) US Princeton, New Jersey 08543 (US). (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY (81) Designated States (unless otherwise indicated, for every [US/US]; Route 206 and Province Line Road, Princeton, kind of national protection available): AE, AG, AL, AM, New Jersey 08543 (US). AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — (72) Inventors: DYCKMAN, Alaric J.; c/o Bristol-Myers DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, Squibb Company, Route 206 and Province Line Road, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, Princeton, New Jersey 08543 (US). DODD, Dharmpal KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, S.; c/o Bristol-Myers Squibb Company, Route 206 and MG, MK, MN, MW, MX, MY, MZ, NA, NG, NL NO, NZ, Province Line Road, Princeton, New Jersey 08543 (US). OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, HAQUE, Tasir Shamsul; c/o Bristol-Myers Squibb Com- SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, pany, Route 206 and Province Line Road, Princeton, New TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — = = _ Jersey 08543 (US). LOMBARDO, Louis J.; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line (84) Designated States (unless otherwise indicated, for every Road, Princeton, New Jersey 08543 (US). MACOR, John kind of regional protection available): ARIPO (BW, GH, E.; 55 Commanders Drive, Washington Crossing, Pennsyl- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, vania 18977 (US). MUSSARI, Christopher P.; c/o Bris- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, tol-Myers Squibb Company, Route 206 and Province Line TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Road, Princeton, New Jersey 08543 (US). PASUNOORI, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Laxman; c/o Syngene International Limited, Biocon Spe- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, cial Economic Zone, Biocon Park, Plot No. 2&3, Bom- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, masandra Industrial Area IV Phase, Jigani Link Road, Bom- KM, ML, MR, NE, SN, TD, TG). = = = — = = = masandra, Karnataka, Bangalore 560 099 (IN). RATNA KUMAR, Sreekantha; c/o Syngene International Limit- Declarations under Rule 4.17: = ed, Biocon Special Economic Zone, Biocon Park, Plot No. — as to applicant's entitlement to apply for and be a granted _ 2&3, Bommasandra Industrial Area IV Phase, Jigani Link patent (Rule 4.17(ii)) = Road, Bommasandra, Karnataka, Bangalore 560 099 (IN). — as to the applicant's entitlement to claim the priority of the = SHERWOOD, Trevor C.; c/o Bristol-Myers Squibb Com- earlier application (Rule 4.17(iii)) = — pany, Route 206 and Province Line Road, Princeton, New — of inventorship (Rule 4.17(iv)) = Jersey 08543 (US). POSY, Shoshana L.; c/o Bristol-My- Published: = ers Squibb Company, Route 206 and Province Line Road, — with international search report (Art. 21(3)) Princeton, New Jersey 08543 (US). SISTLA, Ramesh Ku- mar; c/o Syngene International Limited, Biocon Special _ Economic Zone, Biocon Park, Plot No. 2&3, Bommasan- 1-1 of (54) kir) kir) Title: [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS (IR \ , 4, rn (57) : Disclosed are compounds of Formula (I) or a salt thereof, wherein R 1 , R 2 , R 3 , © ...... © GC R 3 , Nom../. R i , R s R4, R 5 , m, n, and p are defined herein. Also disclosed are methods of using such compounds \ 2 ) P •••-•, \ -I- as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compo- 1-1 I , , sitions comprising such compounds. These compounds are useful in treating inflammatory 0 *-- ..- . - ..„^-N H and autoimmune diseases. N ( 5)° N (I) C