baber/WOPTO huggingface dataset:
Patent CA-2439897-A1 (CA)
Title: Enzyme-activated cytostatic conjugates with integrin ligands
Inventor: ALBERS MARKUS
IPC: A61K31/4375
Filed: 2002-03-07
Abstract: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to v3 integrin antagonists via preferred linki ng units which can be selevtively cleaved by elastase, i.e. by an enzyme which can especially be found in tumour tissue. The preferred linking units provid e sufficient stability of the conjugate of cytostatic and v3 integrin antagoni st in biological fluids and, at the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.
Patent CA-2442369-A1 (CA)
Inventor: EGER CHRISTIAN
IPC: C08K3/36
Filed: 2002-02-28
Abstract: The invention relates to a silicon dioxide dispersion that comprises a) an outer flowable phase containing a1) polymerizable monomers, oligomers and/or prepolymers that can be converted to polymers by non-radical reaction; and/or a2) polymers, b) a disperse phase containing amorphous silicon dioxide. The inventive dispersion is characterized in that the average particle size dmax of the silicon dioxide as measured by small angle neutron scattering (SANS) is between 3 and 50 nm at a maximum half-width of the distribution curve of 1.5 dmax. Such a silicon dioxide dispersion can be easily manufactured even at higher concentrations of the disperse phase and can be used to produce polymer materials that have advantageous properties, especially advantageous mechanical properties.
Patent CA-2442658-A1 (CA)
Inventor: STUDY ROBERT
IPC: G08C19/28
Filed: 2003-02-07
Abstract: La présente invention a trait à un dispositif de commande (11) destiné à être utilisé avec un autre dispositif (tel qu'un opérateur de barrière mobile (12)) comportant de multiples interfaces de mémoire (26) et (27) pour permettre au contenu d'une mémoire d'être copiée vers une autre mémoire créant ainsi un clone effectif de la première mémoire. Cette mémoire copiée peut être aisément enlevée du dispositif de commande (11) pour être ensuite mémorisée séparément en tant que mémoire de réserve ou utilisée en tant que mémoire principale dans un autre dispositif de commande (11). Cela permet d'éviter de manière efficace la nécessité d'enregistrement supplémentaire fastidieux d'émetteurs de télécommande autorisés dans des systèmes où le dispositif de commande (11) dialogue avec un opérateur de barrière mobile (12). Dans un mode de réalisation, un blocage d'information correspondant à n'importe lequel des émetteurs enregistrés autrement peut également être copiée vers la nouvelle mémoire lors de cette opération.
Patent CA-2442756-A1 (CA)
Title: Gas analyzer automated purge/zero process
Inventor: MCGEE PHILLIP
IPC: G01N33/00
Filed: 2003-09-25
Abstract: An apparatus and method for purging and zeroing an analyzer. At times, for good analysis of a gas sample or taking a live reading, the analyzer needs to be zero out and/or purge of contaminants. The analyzer can take a live reading, purge and/or zero in any order. The purge function and zero function can automatically be done before, during or after taking a live reading.
Patent CA-2443050-A1 (CA)
Inventor: TRETIAKOVA ANNA S
IPC: A61P21/04
Filed: 2002-03-29
Abstract: L'invention concerne la découverte du fait que la signalisation par l'intermédiaire d'un récepteur de sérotonine de type 1B, 2, 4 et 6 est importante dans l'activation des cellules T, de sorte que l'inhibition, telle que la signalisation peut être utilisée pour la modulation de la réponse immunitaire. L'immunomodulation est utile pour le traitement de maladies ou d'états immunologiques. Nous avons également découvert que, dans les cellules impliquées dans le processus de cycle cellulaire, l'inhibition de la signalisation de la sérotonine inhibe le processus et induit l'apoptose et des changements morphologiques d'une cellule. Ces effets d'inhibition de la signalisation sérotonergique peuvent être utiles pour la suppression des cellules et pour l'identification de composés qui inhibent la signalisation.
Patent CA-2448556-A1 (CA)
Inventor: HALLENBECK PETER D
IPC: G04G21/00
Filed: 2002-06-13
Abstract: Infrared crosspoint system. An infrared (IR) command code is received at the source location, and processed to produce a packet of information (600) rep-resenting the IR command code (204, 206, 208, 210). This packet can be incor-porated into a communication frame such as an Ethernet frame and forwarded over a network. The frame is parsed at the destination location (306) and the IR command code can be reassembled (310, 312) based on information in the packet. In some embodiments, apparatus including a frequency determination buffer (404), an IR transmitter and receiver (400, 402) and a processing platform (412) is used to implement the invention. The techniques disclosed herein can also be implemented as part of a general purpose, premises automation system, consisting of distributed processing platforms (700, 701, 702, 702).
Patent CA-2454383-A1 (CA)
Inventor: GROF CHRISTOPHER PETER LESLIE
IPC: C12N15/82
Filed: 2001-11-09
Abstract: A method of producing a transgenic monocotyledonous plant includes culturing a thin section explant from a monocotyledonous plant, such as sugarcane, wheat or sorghum, in the presence of an auxin and, optionally, a cytokinin, prior to transformation. It is optimal for the thin section to be oriented during thi s pre-transformation culture period of 1-6 days so that a basal surface is substantially not in contact with the culture medium. The cultured explant i s then transformed followed by a rest period of 4-15 days in a culture medium without selection agent but comprising an auxin and, optionally, a cytokinin . After this rest period, transgenic plants are selectively propagated from th e transformed plant tissue in the presence of a selection agent such as paromomycin sulphate or geneticin. This system provides rapid, efficient generation of transgenic monocotyledonous plants from transformed, non-callu s tissue and thereby reduces the likelihood of somaclonal variation among transgenic progeny.
Patent CA-2455912-A1 (CA)
Title: Chenille en caoutchouc sans noyau
Inventor: MATSUO SHUICHI
IPC: B62D55/24
Filed: 2002-07-30
Abstract: L'invention concerne une chenille en caoutchouc sans noyau aussi efficace qu'une chenille en caoutchouc classique par correction d'un déplacement latéral, y compris en combinaison avec un dispositif de roulement général, et facilement fabriquée à un coût réduit par l'adoption d'une structure simple.
Patent CA-2456445-A1 (CA)
Inventor: GENDRON DENIS J
IPC: H01S3/098
Filed: 2002-08-20
Abstract: La présente invention concerne un nouveau dispositif à impulsion géante qui permet une amélioration importante de la valeur et de la qualité d'un système laser déclenché par l'obtention d'une réduction importante du bruit de brouillage de mode pendant la production de l'impulsion. L'origine du bruit de brouillage de mode dans un laser déclenché est le résultat d'une disponibilité de gain élevé et d'une amplification d'ondes stationnaires concurrentes en formation dont la fréquence optique est le produit d'une sélection naturelle via un brûlage de trou spatial dans le milieu à gain. Ce nouveau dispositif déclenché utilise un Q-switch électro-optique ou acousto-optique actif associé à un dispositif absorbeur saturable de façon à obtenir une pupille de transparence variable optimisée du trajet optique et une synchronisation commandée d'un laser déclenché. Cette nouvelle combinaison offre une plus grande perte de modulation que celle que la technique antérieure permettait avec le seul modulateur actif et elle permet d'obtenir une efficacité de production de gain et d'extraction d'énergie supérieure. Plus particulièrement, elle permet d'utiliser un modulateur (< 100 V) basse tension pour un gain élevé (petit coefficient gain signal > 10) et un fonctionnement en mode déclenché à taux de répétition élevée (>10 kHz). Cette combinaison est destinée à ralentir la production de signaux et à balayer la fréquence de mode longitudinal fondamentale au moins dans l'intervalle spectral libre du résonateur, de sorte qu'elle varie de manière adiabatique pendant la formation d'impulsion déclenchée. Cette invention concerne aussi une géométrie laser qui peut faire l'objet de gain élevé et de puissance élevée destinée à être utilisée avec le nouveau dispositif déclenché proposé. Cette invention permettra de produire de manière rentable des lasers déclenchés fonctionnant dans les modes longitudinal unique et transversal unique (TEMoo).
Patent CA-2457348-A1 (CA)
Title: Rubber and textile mat
Inventor: PEREZ RAUL S
IPC: A47L23/26
Filed: 2002-08-12
Abstract: A mat for use in commercial, residential, and/or automotive applications includes a rubber layer comprising rubber particles and a matrix material proximate the rubber particles. The matrix material comprises a barrier material and a binder material. The mat also includes a textile layer thermally bonded to the rubber layer. The textile layer comprises a backing layer comprising polyester. The textile layer further comprises a tufted textile surface coupled to the backing layer.
Patent CA-2458423-A1 (CA)
Title: Towing kit
Inventor: STANLEY RICHARD J
IPC: B60D1/06
Filed: 2004-02-18
Abstract: A towing accessory kit includes a hitch ball mount, at least one hitch ball adapted for removably securing to the hitch ball mount, a retaining pin and clip for removably securing the hitch ball mount to a trailer hitch receiver, and a holder for engaging the mount, hitch ball, and retaining pin and clip. The holder may define compartments for receiving the towing kit components. The holder may include a base and two sides, with the sides hingedly attached to the base and extending outwardly therefrom whereby, when juxtaposed, projecting compartments are formed for receiving the hitch ball.mount, hitch ball, and retaining pin and clip.     The base typically maintains the holder in an upright plane when the sides are juxtaposed.
Patent CA-2458525-A1 (CA)
Inventor: SANROMA ULISES C
IPC: G01N33/48
Filed: 2002-09-30
Abstract: Disclosed herein is a medium for analyzing a substance in a mixture and meth od of making and using. In particular, the medium comprises a network of at lea st one polymeric fiber having a derivatized polymeric surface which allows immobilization of at least one selective binding agent thereon in a highly dispersed and randomly spaced orientation which forms a tortuous interstitia l path for passage of the mixture therethrough. The substance may be a chemica l substance or a biological substance. Also disclosed are assay matrices, assa y systems and kits comprising the medium.
Patent CA-2458630-A1 (CA)
Inventor: STONE CHARLES
IPC: B01J47/12
Filed: 2002-08-27
Abstract: A process for preparing a graft copolymer membrane is provided comprising exposing a porous polymeric base film to a dose of ionizing radiation, and then contacting the irradiated base film with an emulsion comprising a fluorostyrenic or fluoronaphthyl monomer. The graft copolymer membrane may be densified to render it substantially gas-impermeable.
Patent CA-2459329-A1 (CA)
Title: Infusion device and inlet structure for same
Inventor: BRANDT WILLIAM A
IPC: A61K9/22
Filed: 2002-09-04
Abstract: An infusion device (10) includes a disc-shaped housing (12) that is made fro m a biocompatible material. The housing (12) contains a reservoir (13) for holding a volume of infusion medium, such as a medication to be administered to the patient. The inlet structure (20) is coupled in flow communication wi th the reservoir(13), to allow the reservoir to be filled or re-filled. The housing (12) has an outlet through which the infusion medium may be expelled .
Patent CA-2459840-A1 (CA)
Title: Apparatus for electrodeionization of water
Inventor: SATO SHIN
IPC: B01D61/54
Filed: 2003-06-24
Abstract: An electrodeionization apparatus capable of removing silica and boron highly effectively. In particular, an electrodeionization apparatus comprising an anode compartment (17) having an anode (11), a cathode compartment (18) havi ng a cathode (12) and concentrating compartments (15) and desalting compartment s (16) which are alternately disposed by alternately arranging multiple anion exchange membranes (13) and cation exchange membranes (14) between the anode compartment (17) and the cathode compartment (18), wherein the desalting compartments (16) and the concentrating compartments (15) are each filled wi th an ion exchange body. The ratio (volume ratio) of anion exchange body/cation exchange body is in the range of 8/2 to 5/5. Deionized water is taken out by passing respective electrolytic water through the anode compartments (17) an d the cathode compartments (18), passing concentrated water through the concentrating compartments (15) and passing raw water through the desalting compartments (16). Water whose silica or boron concentration is lower than that of raw water is passed through the concentrating compartments (16) as t he concentrated water in the direction from the deionized water takeout side toward the raw water inflow side of the desalting compartments (16). At leas t portion of the concentrated water flowing out from the concentrating compartments (15) is discharged outside the system.
Patent CA-2460640-A1 (CA)
Title: Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same
Inventor: KURIYAMA KAZUHIKO
IPC: A61P29/00
Filed: 2002-09-25
Abstract: The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects.     The diaryl derivatives of the present invention are represented by the following general formula (1):   (See formula 1) one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]propyl-1,3-propanediol.
Patent CA-2461990-A1 (CA)
Inventor: SHERMAN DANIEL M
IPC: C12Q1/6806
Filed: 2001-10-10
Abstract: L'invention concerne un appareil pour la préparation in-situ de macromolécules par l'intermédiaire d'un plasma à décharge luminescente uniforme, et un procédé mettant en oeuvre cet appareil. Ce procédé et cet appareil sont conçus pour préparer des macromolécules à partir de matériaux biologiques, comprenant au moins de l'ADN, de l'ARN, des saccharides, des lipides et des protéines, d'une façon qui supprime la nécessité d'utiliser des produits chimiques ou des solvants biologiques, des broyeurs, la congélation, ou des détergents. Cette invention permet de travailler à une pression d'une atmosphère. Ce procédé est non destructif, rendant ainsi les macromolécules produites adaptées pour une analyse ou une modification ultérieures par l'intermédiaire de l'exposition à un plasma à décharge luminescente maintenu à une pression sensiblement atmosphérique dans l'air ou dans des environnements de gaz modifiés. Le dispositif comprend une paire d'électrodes métalliques espacées. Au moins une des électrodes est recouverte d'un matériau d'isolation hautement diélectrique. Une source d'alimentation permet d'exciter les électrodes. Selon ce procédé, le matériau biologique est placé sur un substrat ou suspendu dans une solution et ensuite placé à l'intérieur du dispositif. Le matériau biologique et immergé en contact direct avec le plasma ou une espèce active générée par le plasma de manière que l'extérieur du matériau biologique soit scindé, produisant des macromolécules généralement intactes et disponibles pour analyse et/ou modification.
Patent CA-2462353-A1 (CA)
Inventor: SHAW LEON
IPC: A61J1/05
Filed: 2004-03-24
Abstract: A liquid medicament delivery system utilizing a carrier for a dose of liquid medicament. A conduit having an entrance and exit communicates with the carrier to permit the same to travel along the conduit. A propellant and the liquid medicament carried by the conduit are formed into a stable vortex eddy and passed to a mixing chamber where the medicament is delivered through an outflow aperture for use.
Patent CA-2464573-A1 (CA)
Title: Adjustable locator for assembly of trusses
Inventor: ANDERSON WILLIAM W
IPC: B27F7/15
Filed: 2004-04-15
Abstract: A locator for locating and holding a structural member in engagement with an adjacent structural member at a predetermined position of an assembly apparatus during a truss assembly operation. The locator includes a cylindric sleeve having an outer wall configured for engaging the structural member and a bore extending through the sleeve defining an inner wall sized for placement around a stop of the assembly apparatus. The bore is eccentrically positioned in the sleeve. The sleeve is portable, may be secured to the apparatus free from fixed connection, and is rotatable about the stop for adjusting a magnitude of force applied by the sleeve to the structural member.
Patent CA-2470856-A1 (CA)
Title: Substituted imidazolidines, method for the production thereof, use thereof as a drug or for diagnosis, and drug containing substituted imidazolidines
Inventor: LANG HANS-JOCHEN
IPC: A61P25/02
Filed: 2002-12-09
Abstract: The invention relates to new imidazolidine-type compounds of formula (I) in which R1 to R7 have the meanings disclosed in the claims. Said compounds represent potent inhibitors of sodium/hydrogen exchanger (NHE), particularly NHE. These novel compounds are used to produce a drug for the therapy or prophylaxis of the central nervous system, lipometabolism, infestations by ectoparasites, dysfunctions of the gall and for improving respiratory drive. The inventive compounds are therefore used for the therapy of respiratory conditions in the following clinical states and diseases: malfunctioning central respiratory drive (e.g. sleep apnoea, sudden infant death, postoperative hypoxia), muscle-related breathing disturbances, breathing disturbances following long-term respiration, breathing disturbances when adapting to high mountain areas, obstructive sleep apnoea and a mixed type o f sleep apnoea, acute and chronic lung diseases with hypoxia and hypercapnia. Said compounds also increase the muscle tone in the upper respiratory tract so as to suppress snoring.
Patent CA-2472854-A1 (CA)
Inventor: PETERSON MARK H
IPC: G06F19/00
Filed: 2004-07-05
Abstract: An expert diagnostic service system using a distributed architecture for generating expert diagnostic suggestions based on input received from a plurality of diagnostic systems. The expert service system collects data related to effective diagnostic; results, such as effective fixes, corresponding to various symptoms/faults from a plurality of diagnostic systems via a data transmission network, and accumulates the number of each effective fix corresponding to each of the various symptoms. The expert service system then assigns at least one effective fix to one of the various symptoms based on a result of the accumulating step, such as the rank of the accumulated number of each fix. The expert service system uses the assigned fix corresponding to a symptom as expert suggestions.
Patent CA-2473252-A1 (CA)
Title: Plastic hydraulic hammer reduction system
Inventor: YANDLE S ELWOOD II
IPC: F16K17/40
Filed: 2002-01-11
Abstract: A mobile tank car or like vehicle (70) includes a mechanical hydraulic dampening device (30) having kinetic energy dissipating baffles in its interior with no moving parts. The moving tank car carrying a liquid load, such as for example a railroad tank car, including a rupture disc assembly (21) or a safety relief valve at the top of the tank to prevent fracturing of the tank due to excessive pressure. The dampening device is located in line between the rupture disk assembly or safety valve and the liquid load. When the tank is suddenly moved, the shifting liquid load passes through the pipe-like device, impacting against impact surfaces of a baffle, causing its energy and the hydraulic hammer action to be dissipated. In most, if not all, cases the presence of the mechanical baffling device prevents the rupture disk and/or safety relief valve from prematurely operating, by maintaining the hydraulic hammer action down to acceptable limits, preventing the spilling of any of the liquid load which otherwise would have occurred through the rupture disk and/or safety relief valve. The device is relatively small, occupying and extending into far less than 1% of the total tank capacity. The dampening device is of a plastic material having a specially configured body that includes a plastic core with opposed surfaces each carrying a plurality of baffles.
Patent CA-2474041-A1 (CA)
Title: Acyclic anionic six-electron-donor ancillary ligands
Inventor: NAGY SANDOR M
IPC: C07F17/00
Filed: 2002-11-22
Abstract: The present invention provides an improved acyclic anionic six-electron-donor ancillary ligand suitable for being bonded in a transition metal complex. The present invention also provides a transition metal complex that includes at least one acyclic anionic six-electron-donor ancillary ligand which is suitable for use as an olefin polymerization catalyst. The complex includes a Group 3 to 10 transition or lanthanide metal and one or more anionic or neutral ligands in an amount that satisfies the valency of the metal such that the complex has a net zero charge. The present invention also discloses a method for making transition metal complex and a method for using the complex for olefin polymerization.
Patent CA-2474317-A1 (CA)
Title: (6s)-5,6,7,8-tetrahydrofolic acid production process
Inventor: JEQUIER PASCAL
IPC: C07D475/04
Filed: 2003-01-21
Abstract: New process for the production of (6S)-5,6,7,8-tetrahydrofolic acid or derivatives thereof starting from the corresponding (6S, 6R) racemic mixture.  The procedure comprises in the steps of adding an organic acid to a non-alkaline suspension of (6S,6R)-5,6,7,8-tetrahydrofolic acid, up to a pH value in the range of 1 to 3; heating the suspension from 30~ to 80~C; cooling the suspension from 20~ to 60~C, with selective crystallization of the (6S)-isomer. The procedure gives the (6S)-isomer in high yields and with a high degree of stereoselectivity. It follows that the synthetic access to a large number of pharmacologically active stereoisomers of folic acid is simpler and more effective.
Patent CA-2474797-A1 (CA)
Inventor: MINETA TAKAO
IPC: H01J17/04
Filed: 2002-03-05
Abstract: A coil filament in which the volume is reduced as much as possible at the light emitting part in order to reduce the size of a bulb while enhancing the illuminance of illumination light field efficiently. A flatly wound flat coil filament (1) is arranged spirally or annularly such that the axis FL in the long side direction is in parallel with the central axis CL of the coil filament or intersects at an appropriate angle .alpha. including right angle, or arranged while aligning with the radial axis HL of the coil filament or at an appropriate angle .alpha. including the radial axis HL. Alternatively, the flat coil filament is formed into U-shape and a pair of U-shaped flat coil filaments are inserted mutually from the open end such that the inside of each closed end is in noncontact state, or the flat coil filament (1) is formed into a circle and, within the range of circle of circular double coil filaments (5, 10, 12), an appropriate number of linear or circular flat coil filaments (6, 7, 9, 11, 13, 14) are arranged in the direction of the central axis CL of the circle.