Patent SG-11201804814Y-A (SG)
Title: Materials and methods for delivering nucleic acids to cochlear and vestibular cells
Inventor: STANKOVIC KONSTANTINA
IPC: A61K48/00
Filed: 2016-12-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111010111011101111111111011111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....\" WO 2017/100791 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: Street, Newton, Massachusetts 02459 (US). GALEOC, A61K 39/00 (2006.01) A61N 1/32 (2006.01) Gwenaelle; 164 Elgin Street, Newton, Massachusetts A61K 47/42 (2017.01) A61P 27/16 (2006.01) 02459 (US). A61K 48/00 (2006.01) C07K 14/005 (2006.01) (74) Agent: PARSONS, M. Angela; Fish & Richardson P.C., (21) International Application Number: P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). PCT/US2016/066225 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 12 December 2016 (12.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, DO, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, KP, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/266,462 11 December 2015 (11.12.2015) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/266,477 11 December 2015 (11.12.2015) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicants: MASSACHUSETTS EYE AND EAR IN- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, FIRMARY [US/US]; 243 Charles Street, Boston, Mas- ZA, ZM, ZW. sachusetts 02114 (US). THE CHILDREN'S MEDICAL (84) Designated States (unless otherwise indicated, for every [US/US]; 02115 (US). CENTER CORPORATION Street, Boston, Massachusetts 55 Shattuck kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: STANKOVIC, Konstantina; 2 Hawthorne TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Place, #16E, Boston, Massachusetts 02114 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VANDENBERGHE, Luk H.; 14 Indian Hill Road, West- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, on, Massachusetts 02493 (US). HOLT, Jeffrey; 164 Elgin LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: MATERIALS AND METHODS FOR DELIVERING NUCLEIC ACIDS TO COCHLEAR AND VESTIBULAR CELLS (57) : Provided herein are materi- als and methods for efficiently delivering nucleic acids to cochlear and vestibular cells. AAV1 = FIG. I ,-1 . 4 11 C:r IN © © 11 IN 11 © N O WO 2017/100791 Al MIONIMOREMIMOIDEHEDIONNECIMOIBUDIM SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, before the expiration of the time limit for amending the GW, KM, ML, MR, NE, SN, TD, TG). Published: claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))