baber/WOPTO huggingface dataset:
Patent NZ-315324-A (NZ)
Title: Cyclosporin derivatives with anti-hiv effect
Inventor: LUCHINGER JEAN M
IPC: A61K38/00
Filed: 1996-07-17
Abstract: PCT No. PCT/EP96/03129 Sec. 371 Date Dec. 31, 1997 Sec. 102(e) Date Dec. 31, 1997 PCT Filed Jul. 17, 1996 PCT Pub. No. WO97/04005 PCT Pub. Date Feb. 6, 1997The invention concerns new cyclic peptides of general formula (I) in which the letters A to K signify residues of the following amino acids: A is substituted homothreonine of the general formula (II): R1-CH2CH(CH3)-CH(OH)-CH(NHCH3)-COOH in which R1 is n-propyl or propenyl in which the double bond is preferably in the trans configuration; B is  alpha -aminobutyric acid, valine, norvaline or threonine; C is a D-amino acid of the general formula (III): CH3NH-CH(R)-COOH in which R is straight-chain or branched-chain C2-C6 alkyl, alkenyl or alkynyl, whereby these groups may be substituted by hydroxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, alkoxy or acyloxy, COOR2 or CONHR2 in which R2 is straight-chain or branched-chain C1-C4 alkyl X-R3 in which X is O or S and R3 is straight-chain or branched-chain C1-C4 alkyl, alkenyl or alkynyl and, when X is S, R3 may also by aryl or heteroaryl, halogen, preferably fluorine, cyano, CHR4R5 in which R4 is hydrogen, methyl, ethyl or phenyl and R5 is hydrogen, hydroxy, halogen (preferably fluorine), amino, C1-C4 alkylamino, C1-C4 dialkylamino, acyloxy (preferably acetyloxy), tert-butoxycarbonylamino-ethoxy-ethoxy-acetyloxy or alkoxycarbonyl (preferably butoxycarbonyl); D is N-methyl-gamma-hydroxyleucine or N-methyl-gamma-acetyloxyleucine; E is valine; F, I and J are each N-methylleucine; G is alanine; H is D-alanine or D-serine; and K is N-methylvaline. The invention also concerns the preparation of such peptides and their use in the prevention of infection by the human immunodeficiency virus (HIV).
Patent NZ-315955-A (NZ)
Title: Method and apparatus for killing microorganisms
Inventor: GLAZMAN MARK
IPC: C02F1/32
Filed: 1996-08-17
Abstract: A method and apparatus (10) for killing microorganisms in a particle laden fluid medium (11) are disclosed. This method has the steps of providing a germicidal radiation for killing microorganisms (30) and a reflectors (40) for transferring and orienting of the germicidal radiation for killing microorganisms (30); providing a secondary flow (12) of a substantially particles free fluid; the secondary flow (12) is running along or flowing across the surface of the reflectors (40) and establishing a substantially particle free barrier environment maintaining clean the reflectors (40); orienting an emission of the germicidal radiation in a parallel array of beams (32), and passing the fluid medium (11) along a path aligned with the parallel array of beams (32). The apparatus arranged so that the maximum efficiency of use of germicidal energy is achieved, energy consumption for sterilization will decrease, reliability and period between maintenance will increase.
Patent NZ-320523-A (NZ)
Title: Hydroxylamine derivatives and pharmaceutical and cosmetic compositions thereof
Inventor: VIGH LASZLO
IPC: C12N5/0793
Filed: 1996-11-01
Abstract: The use, in the manufacture of a medicament of an effective amount of a hydroxylamine derivative the tautomeric forms of which are represented by formulae (I) and (II) or its salt and/or optically active stereoisomer thereof, wherein, A is an alkyl, substituted alkyl, aralkyl, aralkyl substituted in the aryl and/or in the alkyl moiety, aryl substituted aryl, heteroaryl or substituted heteroaryl group, Z is a covalent bond. oxygen or =NR3 wherein R3 is selected from the group consisting of hydrogen, an alkyl, substituted alkyl, aryl, substituted aryl, aralkyl and aralkyl substituted in the aryl and/or alkyl moiety, R is alkyl or substituted alkyl, X in the tautomer of formula (I) is halo or substituted hydroxy or amino, monosubstituted amino or disubstituted amino group and, X in the tautomer of formula (II) is oxygen, imino or substituted imino group and R' is hydrogen, an alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, aralkyl having substituted aryl or alkyl moiety, acyl or substituted acyl group, and the compounds of formula (I) optionally contain intramolecular ring structures formed by coupling X and a reactive substituent; for increasing expression of a molecular chaperone by an eukaryotic cell that is exposed to a physiological stress.
Patent NZ-323980-A (NZ)
Title: Antiseptic composition containing a quaternary ammonium compound, a chelating agent and a polyol
Inventor: TYERS GERALD DAVID
IPC: A01N33/12
Filed: 1996-12-11
Abstract: queous, topical, ready to use, antiseptic compositions comprising: a) 0.05 to 1 % w/v of a biocidal compound of formula (I) wherein each R1 is independently selected from hydrogen, a C1-4 alkyl group, a C1-4 alkoxy group, a halogen or a hydroxy group; n is 0 to 3; R2 and R3 are independently selected from C1-4 alkyl groups; R4 is a C6-22 alkyl chain (or a mixture thereof), and X is an anion; b) 0.005 to 0.2 % w/v of a chelating agent; and c) 1 to 5 % w/v of a polyhydric alcohol; the composition further comprising substantially no monohydric alcohols.
Patent NZ-331233-A (NZ)
Title: Substituted 4-aminopyrrole (3,2-d) pyrimidine derivatives that selectively bind to mammalian neuropeptide Y (NPY) receptors, and the use in treating feeding disorders and cardiovascular diseases
Inventor: DOW ROBERT LEE
IPC: A61P25/28
Filed: 1998-08-03
Abstract: The use of the compound of Formula (I) for inhibiting or alleviating a pathological condition or physiological disorder in a mammalian subject characterised by or associated with neuropeptide Y. Wherein; R1 is methyl; R3 is phenyl; and R2 is selected from substituents consisting of Net2, HN(CH2)2Net2HN(CH2)3COOH, NHCH2CH2OH, HNPh, HN(CH2)2Ph, Formula (a), Formula (b), Formula (c), Formula (d), piperidinyl, morpholinyl, NHNH2, HNCH(CH3)2, HN(CH2)3CH3, HNCH2(CH3)2, HNCH(CH3)CH2(CH2)3CH3, HNCH2CH=CH2, Formula (e), HNCH2C6H5, or Formula (f).
Patent NZ-337445-A (NZ)
Title: Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
Inventor: DE LA MONTE SUZANNE
IPC: A61P25/00
Filed: 1998-02-26
Abstract: Transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumours, malignant astrocytomas, and glioblastomas, the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumours, malignant astrocytomas, and glioblastomas and antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumours, malignant astrocytomas, and glioblastomas.
Patent NZ-337604-A (NZ)
Title: Use of sodium channel blocker for preventing optic nerve degeneration associated with glaucoma
Inventor: ADORANTE JOSEPH S
IPC: A61K9/08
Filed: 1998-03-26
Abstract: A sodium blocker is used in the manufacture of a medicament i) for maintaining normal intercellular Na and Ca in ganglion cells following a period of anoxia, ii) for preventing retinal ganglion cell death associated with glaucoma in the eye of a mammal and iii) for providing neuroprotective effect to retinal ganglion cells in a the eye of a mammal. The sodium blocker is a composition for blocking of non-inactivating sodium channel activity in the retinal ganglion neuronal cells and can be benzothiazole, riluzole, lubelezole, phenyl benzothiazole or lifaizine.
Patent NZ-337750-A (NZ)
Title: Protein markers for lung cancer and use thereof
Inventor: HANASH SAMIR M
IPC: A61K39/00
Filed: 1998-02-12
Abstract: Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from lung tumors, reveals proteins which are different types of tumors and in control tissues.   Also disclosed is a method of making a monoclonal antibody or antigen binding fragment that comprises: a) immunising an animal with a protein which is overexpressed in lung tumors b) isolating splenocytes from the animal c) fusing the splenocytes with myeloma cells d) growing the fused cells e) testing the fused cells for antibodies which specifically bind to a protein which is overexpressed in lung tumors f) isolating any antibody that binds to a protein which is overexpressed in lung tumors
Patent NZ-337885-A (NZ)
Title: vaccine formulation of an antigen, a TH-1 inducing adjuvant and a sparingly water soluble amino acid
Inventor: WHEELER ALAN
IPC: A61K35/76
Filed: 1999-09-17
Abstract: A composition useful for reducing the susceptibility to or treating or preventing a bacterial or viral infection or cancer comprising: a)	an antigen provided that the antigen is not an allergen; b)	a TH1-inducing adjuvant and c)	a sparingly water soluble amino acid or a derivative thereof such that the adjuvant and antigen allow production for antigenic response. The TH1-inducing adjuvant can be tyrosine or tryptophan and the antigen can be derived from a bacterium, virus or neoplasm.
Patent NZ-502864-A (NZ)
Title: Method of identifying changes in the trophic state of a body of water such as a lake
Inventor: BURNS CHARLES ALBERT
IPC: G01N33/18
Filed: 2000-02-14
Abstract: A method of identifying changes in the tropic state of a body of water includes: a) selecting a plurality of key variables indicative of the tropic state of a body of water; b) measuring the variables over a predetermined time interval to obtain a set of measured data; c) computing residual data by removing seasonal variations from the measured data; d) computing a percentage change of the annualized data for each variable over a specified time interval; e) computing an average of the percentage change of the variables and f) computing a p-value for the average percentage change of the variables.
Patent NZ-519710-A (NZ)
Title: Power driving tool with handle having overmold resiliently mounted
Inventor: DRISCOLL PATRICK J
IPC: B25F5/02
Filed: 2002-04-29
Abstract: Overmold 102 flows through at least one aperture 100 of handle to form a resilient mounting point(s).
Patent NZ-524213-A (NZ)
Title: A target game
Inventor: CHERRY BRENT HUME
IPC: A63F7/30
Filed: 2003-02-17
Abstract: A game for plurality of players comprising a plurality of targets and objects to be tossed is provided. The first steps of the game are to arrange the plurality of targets in spaced relationship in an area of play and to determine penalty zones within that area. The players start at a start position and each tossing a respective one of the object towards a first of the targets in an attempt to get their object to reach the target, and each player, if necessary, making further tosses of their object until it has reached that target. After the first target has been reached by each player, each player tossing their respective object in turn to a second of the targets, and if necessary making further tosses, until the second target is reached, repeating then this operation for all further targets, if any, until all targets have been reached in turn, wherein in each case the player tossing his or her object makes a commencing toss from the target just reached. The game is characterized in that players are given a score or scores corresponding to the total number of tosses required to get their object to each target, and wherein a penalty is added to the score of any player who tosses their object into a penalty zone, or does not maintain a legal tossing position, and wherein at the completion of all tosses the score of each player is calculated to determine a winner of the game.
Patent NZ-524920-A (NZ)
Title: Adjustable dosage syringe
Inventor: FALSEY THOMAS A
IPC: A61M5/315
Filed: 2001-09-24
Abstract: Disclosed herein is a self-zeroing dosage syringe comprising: (a) a syringe barrel which forms a volume sufficient to contain a required dosage of a fluid, a discharge end at one end of the barrel length, a plunger receiving end at the opposite end of the barrel length, (b) said plunger is movably disposed within the barrel and has a length greater than the length of the barrel, and further has at a set of multiple closely spaced indentations disposed along the length thereof, and (c) a movable dosage selection ring which is disposed around the plunger and rotatable about the longitudinal axis of the plunger; characterized in that the dosage selection ring has (1) a sleeve disposed inside the barrel, (2) a calibration on the sleeve thereof for setting the desired dosage by turning the ring until the calibration for a desired dose is reached, (3) a means for engaging the ring with the plunger allowing it to be moved cooperatively with the plunger until the ring dead ends against the syringe barrel thereby releasing the desired dosage.
Patent NZ-524935-A (NZ)
Title: Blue shade Fe-Cr black pigment comprising 40-90% iron oxide 10-60% chromium oxide in a ratio of 1:1 to 5:1 and 0.1-20% manganese oxide
Inventor: LOUCKA WILLIAM GERALD
IPC: C09C1/24
Filed: 2001-09-25
Abstract: A blue shade black pigment composition is described, as well as the method of production, and use in paint, ink and plastic compositions. The composition comprises iron oxide and chrome oxide with the ratio of iron to chromium of about 1:1 to about 5:1 by weight; and manganese oxide. The method of production involves combining iron oxide, chrome oxide, and manganese oxide to form a mixture; heating the mixture to a temperature from about 700oC to about 1300oC for between 1 and 5 hours; and optionally agitating the heated mixture to provide the blue shade black pigment. Also described is a plastic composition containing a plastic and a blue shade black pigment composition containing at least iron oxide, chrome oxide, and manganese oxide.
Patent NZ-527211-A (NZ)
Title: Method and device for insertion of a rigid pig into a flow pipe
Inventor: DE ALMEIDA ALCINO RESENDE
IPC: B08B9/04
Filed: 2001-12-21
Abstract: There is disclosed a method and a device to allow a "rigid" pig to pass into an undersea flow pipe in which a hollow flow-constricting device is in use. The device is provided with a first pipe branch and a second pipe branch. The first pipe branch is provided with a hollow flow-constricting device in it and both first and second pipe branches are provided with shut-off valves, whereby the flow can be diverted to the second pipe branch thereby enabling a rigid pig to pass into such second pipe branch, when necessary.
Patent NZ-528293-A (NZ)
Title: Friction bar assembly
Inventor: DAVIS PAUL MICHAEL
IPC: E05C17/00
Filed: 2003-09-19
Abstract: A window friction bar assembly (100) comprises first and second link arms (3, 12) which have pivot bores (4,6 14, 16) at each end, and first and second attachment plates (8, 18) for attaching the first and second link arms (3, 12) to a window frame through the pivot bores (6, 16). At least one of the attachment plates (8, 18) constitutes a friction attachment device (20), having a hollow cylindrical protrusion (26) on one side, with an outside diameter to allow a sliding fit inside the pivot bore (6, 16). A screw 30 adapted for screwing into the window frame, has a head formed with a radiused face on an inside, so as to expand an end rim (32) of the hollow cylindrical protrusion (26) when tightened, and thereby provide a frictional attachment between the link arm (3, 12) and the attachment plates (8, 18).
Patent NZ-529533-A (NZ)
Title: Solid TCMTB formulations
IPC: A01N25/08
Filed: 1999-02-24
Abstract: The invention provides a solid TCMTB formulation for controlling the growth of at least one microorganism. The use of a solid TCMTB formulation, as compared to a liquid, minimizes user contact and is more readily packaged. A solid TCMTB formulation of the invention contains TCMTB adsorbed onto a water-soluble, salt carrier matrix, with the TCMTB present in an amount effective to control the growth of at least one microorganism, preferably in an aqueous system. Other microbicides and additives may also be incorporated into a solid TCMTB formulation of the invention. In a preferred embodiment, the formulation contains both TCMTB and one or more other microbicides (e.g., methylene bisthiocyanate (MTC)) and a water-soluble, salt carrier matrix. The TCMTB is adsorbed onto the water-soluble salt carrier matrix. The TCMTB and other microbicide are present in a combined antimicrobial amount effective for the control of at least one microorganism. A solid TCMTB formulation may be used in a wide variety of biocide applications. Accordingly, the invention also relates to a method for controlling the growth of at least one microorganism in a liquid, preferably aqueous, system. In particular, the method controls the growth of at least one microorganism in an aqueous system by contacting an aqueous system with a solid TCMTB formulation comprising TCMTB adsorbed onto a water-soluble salt carrier matrix in an amount effective to control the growth of at least one microorganism in the aqueous system.
Patent NZ-531907-A (NZ)
Title: Improvements in furniture combination bed and desk
Inventor: MONESTIER JUAN CARLOS
IPC: A47C17/62
Filed: 2002-09-04
Abstract: Combination bed (4) and desk (3) is disclosed: an articulated parallelogram (6, 8, 10, 11) based system and mechanism that links bed frame (4) and desktop (3) to elements (6, 10) fixed to a wall (or support or furniture body). Bed rotates as a wallbed, and desktop goes down and up always levelled. In raised position, bed lies against the wall, bedding concealed, and cantilever desktop at standard height rests against bed bottom. In the lowered position, the bed is deployed at normal height and desktop goes underneath at floor level. Desktop can admit objects as a PC monitor (up to 0.4 m height) that can remain undisturbed through conversion and stowing.
Patent NZ-532693-A (NZ)
Title: Sintered composite material containing tungsten and bronze
Inventor: ELLIOT KENNETH H
IPC: F42B12/74
Filed: 2002-10-15
Abstract: High-density composite materials comprising tungsten and bronze that are useful as lead replacements in the production of ammunition, weights and other high density articles; the composition of the composite; articles manufactured using the composite; and a process for making the composite are disclosed.
Patent NZ-539624-A (NZ)
Title: Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
Inventor: ARTERBURN LINDA M
IPC: A61K31/60
Filed: 2003-09-29
Abstract: Disclosed is a use of a composition consisting essentially of triglyceride oil, wherein said oil comprises docosahexaenoic acid (DHA) in an amount effective to reduce subclinical inflammation in a subject in the manufacture of a medicament formulated for oral administration for impeding the development or progression of a disease associated with subclinical inflammation, wherein said oil has an eicosapentaenoic acid (EPA) content less than one-fifth that of DHA. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. Subclinical inflammation which is a chronic non-acute systemic inflammation is an underlying cause of many seemingly unrelated diseases associated with aging. The compositions of the disclosure are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients.
Patent NZ-541713-A (NZ)
Title: Method for monitoring characteristics of pharmaceutical compositions during preparation in a fluidized bed
Inventor: FOLESTAD STAFFAN
Filed: 2001-10-16
Abstract: The method comprises the generic use of an optical probe device in spectrometric measurements, the probe device being capable of transmitting a two-dimensional image of radiation emitted from a monitoring area in the process vessel (1).
Patent NZ-541884-A (NZ)
Title: Controlled release composition comprising a physiologically active substance, hydroxynaphthoic acid and a lactic acid polymer
Inventor: YAMAMOTO KAZUMICHI
IPC: A61P25/28
Filed: 2002-06-28
Abstract: Disclosed is a controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3. The composition is used for medicaments for the treatment of prostatic cancer, prostatic hyperplasia, endometriosis, uterine myoma, uterine fibroma, precocious puberty, dysmenorrheal or breast cancer, or as a contraceptive agent.
Patent NZ-547267-A (NZ)
Title: CIPC solutions of a terpene or a terpene oil and uses thereof for antigerminative treatment of bulbs or tubers
Inventor: SARDO ALBERTO
IPC: A01N65/44
Filed: 2004-10-15
Abstract: Disclosed a 3-chlorophenylisopropylcarbamate (CIPC) solution containing one or more of eugenol, isoeugenol, clove oil, D- or L-carvone, common mint oil (spearmint), their salts and/or their mixtures, methods of preparing it, and the use of the solution to treat bulbs or tubers.
Patent NZ-547848-A (NZ)
Title: Intranasal compositions
Inventor: SMITH ALAN
IPC: A61K31/435
Filed: 2004-11-30
Abstract: Provided is a composition for nasal delivery comprising granisetron or a pharmaceutically acceptable salt thereof and chitosan, a salt, a derivative of chitosan which is an ester, ether, or other derivative formed by bonding aryl and/or alkyl groups with the hydroxyl groups of chitosan or chitosan conjugated to polyethylene glycol or a salt of such a derivative. Further provided is the use of the composition in the manufacture of a medicament for nasal administration and for treatment or prevention of nausea and/or vomiting.
Patent NZ-550517-A (NZ)
Title: Loading and unloading apparatus and method
Inventor: PHILLIPS JONELLE MARIE
Filed: 2006-10-12
Abstract: A trailer, suitable for being towed behind a vehicle and which is capable of receiving a container, is disclosed. The trailer is suitable for use with a rolling rack, where the rolling rack includes a rack roller track arrangement supported in an elevated position above a surface on which the rolling rack is standing. The trailer comprises a trailer frame, a housing adapted to enclose a container supported by the trailer frame, and at least one trailer roller-track arrangement supported by the trailer frame. The trailer roller-track arrangement includes a plurality of aligned rollers, where the trailer roller-track arrangement is configured and dimensioned to allow a container to be rolled from the rolling rack into and/or out of the housing onto and/or from the rolling rack when the trailer and the rolling rack are adjacent each other on a surface.
Patent NZ-555653-A (NZ)
Title: Triazole substituted aminobenzophenone compounds
Inventor: OTTOSEN ERIK RYTTER
IPC: A61K31/4192
Filed: 2005-11-28
Abstract: Disclosed are 1,2,3-triazole substituted aminobenzophenone compounds as represented by the general formulae Ia and Ib, wherein R-1 is methyl, chloro, bromo or methoxy; R2 is chloro or methyl; and the remaining substituents are as defined herein. Also disclosed is the use of a compound as defined above for the manufacture of a medicament for the prophylaxis, treatment or amelioration of inflammatory diseases or conditions, or ophthalmic diseases or conditions, or for the treatment or amelioration of cancer.