baber/WOPTO huggingface dataset:
Patent MY-195879-A (MY)
Title: Wax Risk Assessment and Mitigation Using Advanced Data Analytics and Pipe Flow Modeling
Inventor: PEREZ DIAZ PETER LARRY
IPC: G01N33/28
Filed: 2017-04-10
Abstract: Described herein are systems and methods for evaluating and mitigating the wax risks of a given hydrocarbon composition such as crude oil. The disclosed systems and methods enable rapid and ready prediction of wax risks using algorithms based on a small sample of the hydrocarbon composition. The wax risks are predicted using predictive models developed from machine learning. The disclosed systems and methods include mitigation strategies for wax risks that can include chemical additives, operation changes, and/or hydrocarbon blend. (Fig.1)
Patent SG-10201710086R-A (SG)
Title: A multi-hop networking protocol for wide-area energy harvesting sensor network deployments
Inventor: JOHNSTON MATTHEW R
Filed: 2017-12-05
Abstract: A MULTI HOP NETWORKING PROTOCOL FOR WIDE AREA ENERGY HARVESTING SENSOR NETWORK DEPLOYMENTS The present invention provides an EHSN communication protocol that uses a beaconing scheme to facilitate communication between multiple low power sensor nodes. In the illustrative embodiment, the desired sensor data flows through a series of sensor nodes from the origin sensor to a destination node through a set of intermediate relay nodes. Transmissions from one node to another occur using a receiver-initiated beaconing scheme, in which beacons are sent by each node when they have harvested sufficient energy to relay data. The specific set of relay nodes is chosen opportunistically from the total set of nodes in the network, based on which nodes have harvested sufficient energy (and broadcasted the appropriate beacon), and which nodes are optimally positioned to forward data to the destination node. FIGURE 1
Patent SG-11201406927V-A (SG)
Title: Electrolytic cell equipped with concentric electrode pairs
Inventor: BENEDETTO MARIACHIARA
IPC: C25C7/00
Filed: 2013-05-16
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/189670 A1 (51) International Patent Classification: C25B 1/26 (2006.01) C25B 1/00 (2006.01) C25B 1/04 (2006.01) C25B 7/00 (2006.01) C25B 9/06 (2006.01) (21) International Application Number: PCT/EP2013/060179 (22) International Filing Date: 16 May 2013 (16.05.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: MI2012A001048 18 June 2012 (18.06.2012) IT (71) Applicant: INDUSTRIE DE NORA S.P.A. [IT/IT]; Via Bistolfi 35,1-20134 Milano (IT). (72) Inventor: BENEDETTO, Mariachiara; Via Budrio 38A, 1-20153 Milan (IT). (74) Agent: REITSTOTTER KINZEBACH; SternwartstraBe 4, 81679 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: ELECTROLYTIC CELL EQUIPPED WITH CONCENTRIC ELECTRODE PAIRS o l> (57) Abstract: The invention relates to an electrochemical cell, partic­ ularly useful in electrochemical processes carried out with periodic re­ versal of polarity. The cell is equipped with concentric pairs of elec­ trodes arranged in such way a that, in each stage of the process, the cathodic area equal is to the anodic area.
Patent SG-11201806918Q-A (SG)
Title: Anti-acanthamoeba contact lens solution
Inventor: OTAKE HIDEYUKI
IPC: A61L12/14
Filed: 2017-02-16
Abstract: ANTI-ACANTHAMOEBA CONTACT LENS SOLUTION The objective of the present invention is to provide a contact lens solution that is safer to eyes such that it has little or no effects on eye tissue and has the versatility that makes the solution 5 applicable to a wide range of contact lenses, while exhibiting desirable anti-Acanthamoeba activity. The objective is achieved by the anti-Acanthamoeba contact lens solution containing a cationic polymer having an average molecular weight in a range of 150,000 to 1,600,000 and having in its molecule a 10 diallyldimethylammonium chloride unit and an inorganic salt.
Patent SG-11201900197Q-A (SG)
Title: Quaternary ammonium compound, and agent for suppression of generation of volatile organic compound from polyacetal by use of the same
Inventor: KONDO TOMOHIRO
IPC: C08L59/00
Filed: 2017-07-28
Abstract: QUATERNARY AMMONIUM COMPOUND, AND AGENT FOR SUPPRESSION OF GENERATION OF VOLATILE ORGANIC COMPOUND FROM POLYACETAL BY USE OF THE SAME A quaternary ammonium compound represented by the following formula (1): [(R1)m(R2)4-mN+]nXn- (1) wherein each R1 independently represents an unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms; an aryl group having 6 to 20 carbon atoms; an aralkyl group where an unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms is substituted with at least one aryl group having 6 to 20 carbon atoms; or an alkylaryl group where an aryl group having 6 to 20 carbon atoms is substituted with at least one unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms; wherein the unsubstituted alkyl group and the substituted alkyl group are straight, branched, or cyclic; the substituent of the substituted alkyl group is halogen, a hydroxyl group; an aldehyde group, a carboxyl group, an amino group, or an amide group, and any hydrogen atom in the unsubstituted alkyl group, aryl group, aralkyl group, and alkylaryl group may be replaced by halogen; each R2 independently represents a group having 2 to 60 carbon atoms and 2 to 30 oxygen atoms, the group represented by the following formula: -(RO)k-H, wherein R represents a substituted or unsubstituted alkyl group and k represents a natural number of 2 or more; m and n each represent an integer of 1 to 3; and X represents a hydroxyl group, or an acid residue of a compound selected from the group consisting of a monocarboxylic acid having 1 to 20 carbon atoms, a hydroacid, an oxo-acid, an inorganic thioacid, and an organic thioacid having 1 to 20 carbon atoms, the acid residue being a group including no nitrogen atom.
Patent SG-11201900812Y-A (SG)
Title: Asphalt composition
Inventor: TAKAHASHI HIROMICHI
IPC: E01C7/30
Filed: 2017-07-18
Abstract: The present invention relates to an asphalt composition which is excellent in storage stability at a high temperature, an asphalt mixture, a method for producing the same, and a road paving method. Provided are [1] an asphalt composition containing asphalt, a polyester resin, and a dispersant; [2] an asphalt mixture containing the asphalt composition as set forth above in [1] and an aggregate; [3] a road paving method including a step of laying the asphalt mixture as set forth above in [2], thereby forming an asphalt paving material layer; and [4] a method for producing an asphalt mixture including mixing asphalt, a polyester resin, a dispersant, and an aggregate at 130 ° C or higher and 200 ° C or lower.
Patent SG-11201908121U-A (SG)
Title: Vehicle assignment management device, vehicle assignment management method, and mobility system
Inventor: UCHIDA KOJI
IPC: G08G1/123
Filed: 2018-03-30
Abstract: In a vehicle assignment management device according to the present invention, a route notification unit notifies a target vehicle of a route along which the target vehicle will run. A position-receiving unit receives position information at a plurality of timings from each of a plurality of vehicles including the target vehicle. A range 5 notification unit notifies the target vehicle of a permissible range representing a range in which the target vehicle can run on at a plurality of timings on the basis of the position information of the plurality of vehicles.
Patent HU-204581-B (HU)
Title: Method for coating paper, textile and foil-like products with silicone layer
Inventor: ERTSEY ATTILA
IPC: D06M13/50
Filed: 1989-01-02
Abstract: Paper, textile and foil type substrates are pretreated prior to silicone coating. The pretreating agent contains a mixt. of esters of orthosilicic (RO)nSi(OC2H4Cl)4-n (I); ortho-boric-, B(OR)3 (II); and ortho-titanic-, Ti(OR)4 (III); -acids. R = 1-4C straight chain alkyl gps. and n = 0, 1, 2, 3 integers. The concn. of (II)+(III) = 5-40%, and in this the pretreating mix also contains a solvent. The thin topcoat is based on di:methyl-siloxane polymer with silanol end gps. (IV) and also contains a crosslinking agent (V) with at least three Si-H or Si-OR functional gps. per each molecule and a metal carboxylate type condensn. catalyst (VI).
Patent HU-214585-B (HU)
Inventor: KANE JOHN MICHAEL
IPC: A61K31/41
Filed: 1988-01-25
Abstract: A találmány tárgya eljárás (I) általánős képletű vegyületethatóanyagként tartalmazó új hatású, azaz izőmlazító, görcsőldó ésszőrőngásgátló hatású gyógyszerkészítmények előállítására. Az (I)általánős képletben q értéke 0, 1 vagy 2; Ar jelentése fenilcsőpőrt; R1 jelentése 1–6 szénatőmős alkilcsőpőrt, R2 jelentése 1–6 szénatőmős alkilcsőpőrt; R jelentése halőgénatőm vagy triflűőr-metil-csőpőrt; n értéke 0 vagy 1. ŕ
Patent AT-410586-B (AT)
IPC: F28F9/26
Filed: 1999-02-16
Granted: 2003-06-25
Abstract: The heat exchanger has flow (1) and return collection tubes (2), and a pipe system (3). The pipe ends are fitted and welded into holder sleeves (4) on the tube ends. The sleeve ends away from the tubes have an integral ring-shaped holder flange (5) to surround the pipe inserted into it. The inner diameter of the flange is larger than that of the holder sleeve. Pipes and collection tubes are of weldable plastic, esp. polypropylene.
Patent AT-399814-B (AT)
Title: Box frame for a bed frame or the like
IPC: F16B12/54
Filed: 1994-02-25
Granted: 1995-07-25
Abstract: A box frame 2 for a bed frame 1 or the like has mitred joints 4 between the limbs of the box 5, 6, and supporting feet 3 in the corners. In order to achieve a firm and nevertheless detachable connection between the frame parts without any metal parts, the supporting feet 3 in each case form two inclined faces 9 to support the box limbs 5, 6 to be butt jointed, said inclined faces 9 being located in planes determined by a common section line L running downwards in the butt plane from the outer corner edge 10 to the inner corner edge 11 and in each case a straight line G running in the longitudinal direction of the box limbs 5, 6, the box limbs 5, 6 form outer supporting faces 12 at both ends and associated with the inclined faces 9 which with the butt faces 14, result in an outer edge 13 which is matched in its oblique course to the section lines L, and provided at the supporting feet 3 are guides 15, 16 which are aligned in the direction of the supporting feet and interact in a form-fitting manner with the box limbs 5, 6. <IMAGE>
Patent AT-385565-B (AT)
Title: Cage for connecting-rod bearings
IPC: F16C9/04
Filed: 1986-03-07
Granted: 1988-04-25
Abstract: The invention relates to a cage for connecting-rod bearings of 2-stroke and 4-stroke internal combustion engines, in particular for heavy loads and high rotational speeds. The object is to improve the operational characteristics of such a connecting-rod bearing cage. This is achieved by virtue of the fact that the cage is made of titanium.
Patent DK-163152-B (DK)
Title: Ionization level detector
Inventor: NUDELMONT JEAN-CLAUDE
IPC: G08B17/11
Filed: 1984-02-10
Abstract: Ionization of a medium being monitored is caused by an electric arc between a first pair of electrodes, while the conductivity of the medium between two measuring electrodes controls at least one feedback circuit which indicates relative rates of decay of the ions, as a function of variations in the number and mobility of ionized particles in the ambient medium.
Patent HU-197985-B (HU)
Title: Method for producing antibacterial lyophilized preparation
Inventor: KOHNO KEIICHI
IPC: A61K9/00
Filed: 1988-01-14
Abstract: An antibacterial lyophilized preparation which comprises as an active ingredient aspoxicillin and a basic salt of aspoxicillin in a molar ratio of 1 : about 0.7 to 7 and optionally an alkali metal halide as a stabilizer, a method for preparing the same, and the use of such a preparation for the manufacture of a medicament are provided. The antibacterial lyophilized preparation may be rapidly dissolved in distilled water to give a stable solution which can be injected to patients for the treatment of various bacterial infectious diseases.
Patent HU-210248-B (HU)
Title: Process for preparing 3-l-(5-thioxo-l-prolyl)-thiazolidine-4-carboxylic acid, derivatives thereof and pharmaceutical compositions containing them
Inventor: COPPI GERMANO
IPC: C07K5/078
Filed: 1991-01-22
Abstract: 3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and the derivatives thereof have valuable immunostimulating, antioxidant, antiradical and antiageing properties. They are prepared by thionating the corresponding 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid derivatives or by condensing 5-thioxo-L-proline with the corresponding L-thiazolidine-4-carboxylic acid derivatives.
Patent HU-198951-B (HU)
Title: Process for producing new renin inhibiting peptides and pharmaceutical compositions comprising such peptides as active ingredient
Inventor: MATSUEDA REI
IPC: C07K5/083
Filed: 1985-02-01
Abstract: Compounds of formula
     wherein
     R' represents alkyl having an α-amino or protected α-amino substituent and an aryl, heterocyclic or heterocyclic- dithio substituent;   R 2  represents a variety of aliphatic and cycloaliphatic hydrocarbon groups, which may be substituted;   R 3  represents isobutyl, sec-butyl, benzyl or (C 3 -C S  cyclo- elkyl)methyl; and   X represents a group of formula -CH(-A-R")-Y)   
     (in which: A represents a single bond or an alkylene group: R 4  represents an optionally protected carboxy group, an optionally N-substituted carbamoyl group, an optionally N-substituted carbazoyl group or an acyl group; and Y represents a hydroxy group, a mercapto group or a formyl group), or
     a group of formula -P(O)(R 5 )-OH   
     (in which R 5  represents an alkyl group having at least one optionally protected carboxy, N-substituted carbamoyl, optionally N-substituted carbazoyl, C 2 -C 7  aliphatic carboxylic acyl or aromatic carboxylic acyl substituent)]; and their salts are renin inhibitors, which may be used in the treatment of angiotensin-induced hypertension.
Patent HU-200837-B (HU)
Title: Device for dynamic and static measuring of the means advancing on permanent way, as railway cars and lorries
Inventor: BOD PETER
IPC: G01G19/04
Filed: 1987-02-18
Abstract: Apparatus for statically and dynamically weighing track-bound vehicles, such as railroad cars, conveyors, lorries, the apparatus having at least one unit which serves for weighing and adjoins the track used by the transport means. The apparatus according to the invention can be characterised in that every single weighing unit has at least one weighing track section or weighing rail section installed so as to be capable of being placed immovably with respect to the other parts of the track, and in that the installed weighing track section or weighing rail section is formed by a weighing track bedding or a weighing rail bedding and a weighing track insert or weighing rail insert, the insert being guided vertically in the bedding, having a travelling surface which freely adjoins the other parts of the track, and being supported by its ends on in each case one balance cell, while the balance points are connected to a device for measuring the force due to gravity, which device is provided with a microprocessor. <IMAGE>
Patent LT-3199-B (LT)
Title: Biodegradable non-crosslinked polymers of low or zero-water-solubility
Inventor: KLAVENESS JO
IPC: A61K49/22
Filed: 1993-03-05
Abstract: PCT No. PCT/GB93/00469 Sec. 371 Date Jan. 10, 1995 Sec. 102(e) Date Jan. 10, 1995 PCT Filed Mar. 5, 1993 PCT Pub. No. W093/18070 PCT Pub. Date Sep. 16, 1993The invention relates to non-crosslinked non-polypeptide polymers containing biodegradable lipophilic side chains incorporating methylene diester units of the formula -[-CO-O-C(R1R2)-O-CO-]-, where R1 and R2 each represents a hydrogen atom or a carbon-attached monovalent organic group or R1 and R2 together form a carbon-attached divalent organic group. The lipophilic moieties are biodegradatively cleavable to yield a water-soluble polymer.
Patent SE-332445-B (SE)
Inventor: DAVIES E
IPC: H03K3/2893
Filed: 1966-01-18
Abstract: 1,134,222. Transistor bi-stable circuits. MARCONI CO. Ltd. 21 Dec., 1965 [8 Feb., 1965], No. 5464/65. Heading H3T. A Schmitt trigger circuit wherein the point X in the collector circuit of the input transistor T1, which is connected to the base of the output transistor T2 through a circuit including a Zener diode D1, is so chosen that only a small portion of the collector load circuit of the first transistor T1 is used as a low impedance driving source for the second transistor T2. The series chain of Zener diode D2 and resistor R7 (the value of R7 being equal to the parallel sum of R3 and the input impedance of transistor T2, seen at Y and the values of R12 and R16 being equal) is to provide balance in the outputs 3, 4, but may be omitted. Resistor R6 limits the base current of transistor T2.
Patent YU-48993-B (YU)
Inventor: BELMONT A JAMES
IPC: C09D11/02
Filed: 1995-12-14
Abstract: Proizvod cadi koji ima organsku grupu vezanu na cad, koji se dobija postupkom koji obuhvata fazu reagovanja bar jedne diazonijum soli sa cadu u proticnoj reakcionoj sredini, gde pomenuta diazonium so se generise in situ iz primarnog amina, proticna sredina je vodena sredina, i primarni amin je amin formule AyArNH2, gde Ar je aromaticni ili heteroaromaticni radikal; A, koje moze da bude isto ili razlicito kada je y vece od 1, je nezavisno supstituent na aromaticnom radikalu odabranom od: - funkcionalne grupe koja sadrzi racvasti ili neracvasti C1-C20 supstituisan alkil, nesupstituisan ili supstituisan alkenil, nesupstituisan ili supstituisan alkinil, nesupstituisan ili supstituisan heteroaril; nesupstituisan ili supstituisan alkilaril; nesupstituisan ili supstituisan arilalkil; - funkcionalne grupe izabrane iz grupe koja sadrzi OR, COR, OCOR, so karboksilata, CN, NR2, SO3H, sulfonat so, OSO3H, OSO3-soli, NR(COR), CONR2, NO2, OPO3H2, monobaznu ili dibaznu so fosfata, PO3H2, monobaznu ili dibaznu so fosfonata, N=NR, N2+X-, NR3+X-PR3+X-, SkR, SO2NRR1, SO2SR, SNRR1, SSO3H, SSO3-so, SNQ, SO2NQ, CO2NQ, S-(1,4-piperazindiil)-SR, 2-(1,3-ditianil), 2-(1,3-ditiolanil), SOR i SO2R - linearnog, racvastog, aromaticnog ili ciklicnog ugljovodonicnog radikala, supstituisanog sa jednom ili vise pomenutih funkcionalnih grupa gde je R i R1, koji mogu biti isti ili razliciti, su vodonik; racvasti ili neracvasti C1-C20 nesupstituisan ili supstituisan alkil, alkenil ili alkinil; nesupstituisan ili supstituisan aril; nesupstituisan ili supstituisan heteroaril; nesupstituisan ili supstituisan alkilaril; ili nesupstituisan ili supstituisan arilalkil; k je ceo broj, od 1 do 8; X- je halid ili anjoj izveden iz mineralne ili organske kiseline; y je ceo broj od 1 do ukupnog broja -CH radikala prisutnih u aromaticnom radikalu; i Q je (CH2)w,(CH2)xO(CH2)z,(CH2)xNR(CH2)z ili (CH2)xS(SH2)z, gde x je 1 do 6, z je 1 do 6 i w je 2 do 6. Prijava sadrzi jos 12 nezavisnih i 50 zavisnih zahteva
Patent RS-49996-B (RS)
Title: PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY
Inventor: MILIVOJEVIC DUSAN
IPC: A61K31/21
Filed: 1999-09-17
Abstract: Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as and antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergilus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicilium genus, some are obtained by treating the fermentation products using the method of chemical synthesis or they are the products of total chemical synthesis. The purity of the active ingredient is an important factor for manufacturing the safe and effective pharmaceutical, especially if the pharmaceutical product must be taken on a longer term basis in the treatment or prevention of high plasma cholesterol. The accumulation of the impurities from the pharmaceuticals of lower purity may cause many side effects during the medical treatment. The present invention relates to a new industrial process for the isolation of HMG-CoA reductase inhibitors using so-called displacement chromatography. Use of the invention enables to obtain HMG-CoA reductase inhibitors of high purity, with high yields, lower production costs and suitable ecological balance.
Patent ZA-86616-B (ZA)
Title: Flap for tires
Inventor: BERILLON JEAN-BERNARD
IPC: B60B21/12
Filed: 1986-01-28
Abstract: A flap for tires has lateral wings at the ends of which there is an extension which, in stress-free condition, is spaced axially inwards from the inner wall of the tire so that, upon inflation, the inner tube first of all protrudes towards the inside of the inflatable cavity before it is flattened against the tire.
Patent ZA-92375-B (ZA)
Title: Medium consistency pulp ozone bleaching.
Inventor: PHILLIPS JOSEPH R
IPC: D21C9/153
Filed: 1992-01-20
Abstract: Medium consistency (e.g. about 6-15%) paper pulp (from 38) is effectively bleached with ozone (from 16) in a carrier gas (typically oxygen) by effecting efficient separation of carrier gas from the pulp after reaction with the ozone, and introducing the ozone into the pulp at a pressure of about 10-13 bar. Ozone in oxygen and medium consistency paper pulp are fed to a fluidizing mixer (12); the intimate uniform mixture produced is then passed upwardly in a reaction vessel (17) until about 99% of the ozone has been consumed, and then separation of gas from the pulp is initiated by moving the pulp mixture into a generally horizontal tube (21) leading to a gas zone in a large diameter retention vessel (22). A pressurized gas pad (26) is maintained at and above the introduction of the pulp into the retention vessel, while the level (29) of pulp in the retention vessel is maintained below the point of introduction. The pulp may be withdrawn from the retention vessel with a fluidizing degassing pump (32), and the pressurized gas removed from the top of the vessel (through 35) may be fed to an apparatus (61) using oxygen gas under pressure. <IMAGE>   <IMAGE>
Patent ZA-92389-B (ZA)
Title: Method for detection of anti-rna-antibodies
Inventor: VENROOIJ WALTHER JACOBUS VAN
IPC: G01N33/564
Filed: 1992-01-20
Abstract: PCT No. PCT/EP92/00106 Sec. 371 Date Sep. 20, 1993 Sec. 102(e) Date Sep. 20, 1993 PCT Filed Jan. 16, 1992 PCT Pub. No. WO90/10229 PCT Pub. Date Sep. 7, 1990.Method for monitoring patients having connective tissue autoimmune diseases comprising contacting patient specimens with (U1)RNA and detecting immune complexes formed, the level of reaction indicating the severity of the disease.