Patent SG-11201907369T-A (SG)
Title: Anti-factor d antibodies and uses thereof
Inventor: SONG WENCHAO
IPC: C07K16/40
Filed: 2018-02-09
Abstract: Clqantibody () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIP0 1 PCT ill mu °mons °nolo DID IIH mo iflo oimIE (10) International Publication Number WO 2018/148486 Al (51) International Patent Classification: C07K 16/40 (2006.01) (21) International Application Number: PCT/US2018/017537 (22) International Filing Date: 09 February 2018 (09.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/457,477 10 February 2017 (10.02.2017) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: SONG, Wenchao; 213 Cornell Drive, Bryn Mawr, PA 19010 (US). ZHOU, Lin; 213 Cornaell Drive, Bryn Mawr, PA 19004 (US). SATO, Sayaka; 2130 Lo- cust Street, Apt. Al, Philadelphia, PA 19103 (US). MIWA, Takashi; 191 Prisidential Blvd., Unit 323, Bala Cynwyd, PA 19004 (US). GULLIPALLI, Damodar; 4007 Wood- land Avenue, Apt. 13, Philadelphia, PA 19104 (US). GOL- LA, Madhu; 4403 Walnut Street, Apt. 1A, Philadelphia, PA 19104 (US). (74) Agent: HAAS, Dennis, L. et al.; Riverside Law, LLP, Glenhardie Corporate Center, 1285 Drummers Lane, Suite 202, Wayne, PA 19087 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: ANTI-FACTOR D ANTIBODIES AND USES THEREOF • \4L 1° ' . logenic Sponisrisdiis X complex flurfacas hydrolysis of C8 Figure 1 1 -1 (57) : This invention relates to selective inhibition of the alternative pathway (AP) of the complement system using an an- ti-factor D antibody. Specifically, the invention relates to methods of treating an AP-mediated disease or AP-mediated disorder in an C individual by contacting the individual with an anti-factor D antibody. [Continued on next page] WO 2018/148486 Al MIDEDIMOMMIDIREI013010HEMIEMMOVOIMIE MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))