Patent SG-11201406987U-A (SG)
Title: Glucokinase activator compositions for the treatment of diabetes
Inventor: VALCARCE LOPEZ MARIA CARMEN
IPC: A61P3/10
Filed: 2013-05-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOI PCT (10) International Publication Number WO 2013/173417 A3 (51) International Patent Classification: A61K38/26 (2006.01) A61P3/10 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) A61K31/426 (2006.01) A61P 9/12 (2006.01) A61K31/4985 (2006.01) A61P 3/04 (2006.01) A61P3/06 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/041076 15 May 2013 (15.05.2013) English (30) Priority Data: 61/648,110 17 May 2012 (17.05.2012) English US (71) Applicant: TRANSTECH PHARMA, LLC [US/US]; 4170 Mendenhall Oaks Parkway, High Point, North Caro­ lina 27265 (US). (72) Inventors: VALCARCE LOPEZ, Maria Carmen; 1785 Deer Run Court, Oak Ridge, North Carolina 27310 (US). FONG, Tung; 23 Smithwold Road, Somerset, New Jersey 08873 (US). (74) Agent: ROLLINS, Samuel B.; 4170 Mendenhall Oaks Parkway, High Point, North Carolina 27265 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, [Continued on next page] (54) Title: GLUCOKINASE ACTIVATOR COMPOSITIONS FOR THE TREATMENT OF DIABETES :§i40 1120 3100 I 80 :!• 60 'i 40 W i/t M 20 3 i/i •S 0 ANOVA p=0.0007 p=0.002 -L -L -L -L i-h i-h i-h Veh FRI-1 25 mpk Exenatide 12 ugAg Combination (57) Abstract: The present invention relates to pharmaceutical compositions comprising {2-[3-cyclohexyl-3-(trans-4- propoxy-cyclohexyl)-ureido]-thiazol-5-yl- sulfanyl}-acetic acid (FRI-1) in combina­ tion with an anti-diabetic drug selected from the group consisting of metformin, sitagliptin or exenatide. The present inven­ tion also relates to the use of the pharma­ ceutical compositions in restoring insulin sensitivity and treating type II diabetes, in­ cluding reducing body weight in subjects undergoing type diabetes treatment. II FIGURES WO 2013/173417 A3 I lllll llllllll II llllll III lllll lllll lllll lllll III III III lllll lllll lllll llll lllllll llll llll llll GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 20 February 2014 — with international search report (Art. 21(3))