baber/WOPTO huggingface dataset:
Patent SG-173405-A1 (SG)
Title: Method for predicting protein aggregation and designing aggregation inhibitors
Inventor: KOHLHOFF KAI J
IPC: G16B15/30
Filed: 2007-07-24
Abstract: The present invention provides methods of predicting protein aggregation and designing aggregation inhibitors. One such method for predicting potential protein aggregation inhibiting peptide sequences, includes the steps of: a) identifying a peptide sequence forming at least part of an aggregation region in a target protein; b) testing whether said peptide sequence forms part of a B-sheet; c) if a positive result is achieved in step b), extracting the adjacent strands of that sheet; d) identifying residues in the adjacent strands to said peptide sequence whose side chains interact with said peptide sequence, those residues forming a potential protein aggregation inhibiting peptide sequence. The present invention also provides methods of designing compounds using the residues identified in the above method; compounds produced by the methods and computer programs for carrying out the above methods.FIGURE 4
Patent SG-176110-A1 (SG)
Title: Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders
Inventor: CALLEGARO LANFRANCO
IPC: A61K35/28
Filed: 2010-06-29
Abstract: The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20°C and at shear rate of D=350 s-1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.
Patent SG-176211-A1 (SG)
Title: Process for the production of benzofurans
Inventor: KRETZSCHMAR GERHARD
Filed: 2010-05-26
Abstract: A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
Patent SG-177309-A1 (SG)
Title: 3-cyanoquinoline tablet formulations and uses thereof
Inventor: KAUL GOLDI
Filed: 2010-06-30
Abstract: The present invention provides solid compositions comprising a 3-cyanoquinoline, SKI-606, and further comprising croscarmellose sodium, Tween, or both.
Patent SG-179177-A1 (SG)
Title: Fracturing and gravel packing tool with shifting ability between squeeze and circulate while supporting an inner string assembly in a single position
Inventor: CLEM NICHOLAS J
Filed: 2010-08-25
Abstract: A fracturing and gravel packing tool has features that prevent well swabbing when the tool is picked up with respect to a set isolation packer. An upper or jet valve allows switching between the squeeze and circulation positions without risk of closing the wash pipe valve. The wash pipe valve can only be closed with multiple movements in opposed direction that occur after a predetermined force is held for a finite time to allow movement that arms the wash pipe valve. The jet valve can prevent fluid loss to the formation when being set down whether the crossover tool is supported on the packer or on the smart collet.
Patent SG-182166-A1 (SG)
Title: Improvement of power output in hydraulic systems
Inventor: NEVEU CHRISTIAN DANIEL GEORGES
Filed: 2008-03-17
Abstract: -41 - IMPROVEMENT OF POWER OUTPUT IN HYDRAULIC SYSTEMS AbstractThe present invention describes use of a fluid having a VI of at least 130 to improve the power output of a hydraulic system. Preferentially, engine speed can be maintained at the same rate selected while using the standard HM oil, and deliver >3% higher hydraulic power output.Figure: 1
Patent SG-181898-A1 (SG)
Title: Slide and shell container
Inventor: CHATELAIN LUCAS
Filed: 2010-11-30
Abstract: A slide and shell container (1), comprising a shell (2), and a slide (7), which is movable in the shell (2) along a sliding path from a closed position to an open position, wherein in the closed position the interior of the container (1) is inaccessible, and wherein in the open position the interior of the container (1) is accessible. The shell (2) comprises a guide slit (8), extending along the sliding path, wherein a guide means (57, 59) of the slide (7) engages with the guide slit (8). Further, a single blank for forming a slide and a single blank for forming a guide means is disclosed.
Patent SG-182805-A1 (SG)
Title: Mobile solar power-generating system
Inventor: SENTINELLI SERGIO
IPC: H02S30/20
Filed: 2011-02-03
Abstract: A mobile solar power-generating system comprises a prismatic container (1) having a top wall (10), a bottom wall (11) and side walls. A central photovoltaic panel (6) is supported in a tiltable manner on the top wall (10) by supporting means, on each of the sides of the central photovoltaic (6) being hinged a correspondent transversal ph tovoltaic panel (61, 62, 63, 64) hanging downward in a rest position and being able to rotate 90 degrees upward. On a side of each transversal photovoltaic panel (61, 62, 63, 64) is hinged a side photovoltaic panel (610, 620, 630, 640) that is designed to fold down with respect to the relevant transversal photovoltaic panel (61, 62, 63, 64). Mutual engagement means are provided for keeping coplanar the transversal photovoltaic panels (61, 62, 63, 64) and the side photovoltaic panels (610, 620, 630, 640) to the central photovoltaic panel (6) when the power-generating system is in an operating position.
Patent SG-184524-A1 (SG)
Title: Combination of a macrocyclic inhibitor of hcv, a non-nucleoside and a nucleoside
Inventor: LIN TSE-I
Filed: 2011-04-13
Abstract: The present invention relates to a combination of a macrocyclic HCV protease inhibitor, a macrocyclic non-nucleoside HCV polymerase inhibitor and a nucleoside HCV polymerase inhibitor.
Patent SG-186360-A1 (SG)
Title: Methods, devices, and materials for metallization
Inventor: KOLICS ARTUR
Filed: 2011-06-30
Abstract: A method of making an electronic device which in one embodiment comprises providing a substrate, electrolessly depositing a barrier metal at least on portions of the substrate, and using wet chemistry such as electroless deposition to deposit a substantially gold-free wetting layer having solder wettability onto the barrier metal. An electronic device which in one embodiment comprises a metallization stack. The metallization stack comprises a barrier metal deposited electrolessly and a substantially gold-free wetting layer deposited on the barrier metal, and the wetting layer is wettable by solder.
Patent SG-187416-A1 (SG)
Title: Piperidine derivatives as nk1 antagonists
Inventor: PALANI ANANDAN
Filed: 2005-06-29
Abstract: A compound having the general structure shown in Formula I:RI R2 5 (i)or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NKI receptors, for example10 various physiological disorders, symptoms or diseases, including emesls, depression, anxiety and cough.No figure
Patent WO-2013109194-A1 (WO)
Title: Induced pluripotent stem cell (ipsc)-derived cardiomyocyte-like cells and uses thereof
Inventor: SHIM WINSTON
IPC: G01N33/50
Filed: 2013-01-21
Abstract: The present invention relates to a method for screening an agent as a drug candidate using induced pluripotent stem cell-derived cardiomyocyte-like cells (iPSC-CMs). The method is useful for screening cardiovascular agents and/or agents affecting cardiac function. The method is also useful for assessing the cardiotoxicity of agents. The present invention also relates to a method for predicting risk of and/or predisposition to cardiac arrhythmia in a subject.
Patent SG-186887-A1 (SG)
Title: Skin-whitening composition containing extracts from trees including paper mulberry
Inventor: LEE JIN YOUNG
Filed: 2011-07-04
Abstract: The present invention relates to a skin-whitening composition comprising a paper mulberry extract, and more particularly to a skin-whitening composition containing an extract of Acer barbinerve Max., Acer barbinervis var.glabrescens, Wikstroemia trichotoma, Acer tschonoskii var. rubripes, Edgeworthia chrysantha, Broussonetia papyri fera for. Oppositifolia, Broussonetia papyrifera for. Lucida, Daphne kamtschtica or Broussonetia kazinoki Siebold, which can be used safely on the skin without causing side effects and hasexcellent effects of inhibiting melanin production and pigmentation.[No Figure]
Patent SG-191958-A1 (SG)
Title: Running tool
Inventor: THORNBURROW EDWARD T
Filed: 2012-01-27
Abstract: A running tool (10) for inserting and setting an assembly into a bore in a well, the tool comprising a main body (11) having a hydraulic cylinder (12) for actuating one or more locking elements (60, 61) on the main body for, in use, reaction with the bore, an outer sleeve (40) rotatably mounted on the main body, a rotatable mandrel (13) to which, in use, torque is applied and means (42, 43, 44) for transmitting the torque from the mandrel to the outer sleeve.
Patent SG-192017-A1 (SG)
Title: Protection of microbial cells from acidic degradation
Inventor: GUENZBURG WALTER H
IPC: A61K35/742
Filed: 2012-01-25
Abstract: A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host. Described is how cells are encapsulated with said material, and under which conditions the encapsulated cells survive the stomach passage and how the microbial cells or enzyme produced by said microbial cells can exit the microcapsules allowing the cells and/or the enzymes produced within the microcapsules to provide their health benefit. This technology will play an important role in the improvement of food, especially probiotic foods or the delivery of food additives to improve human and animal health and wherein these cells are still able to release their generated products e.g. enzymes and/or other nutritional factors into the surrounding environment after having been exposed to an acidic environment first.
Patent SG-192168-A1 (SG)
Title: Method and apparatus for skin resurfacing
Inventor: AUSTEN WILLIAM G
Filed: 2012-01-27
Abstract: Exemplary embodiments of method and apparatus are provided for resurfacing of skin that includes formation of a plurality of small holes, e.g., having widths less than about 1 mm or 0.5 mm, using a mechanical apparatus, thus avoiding generation of thermal damage as occurs with conventional laser resurfacing procedures and devices. The holes formed can be well-tolerated by the skin, and can exhibit shorter healing times and less swelling than conventional resurfacing procedures. The apparatus includes one or more needles adapted to remove a small portion of tissue when inserted into and withdrawn from the skin. The fractional surface coverage of the holes can be between about 0.1 and 0.7, or between about 0.2 and 0.5. The exemplary method and apparatus can produce cosmetic effects such as increases in collagen content, epidermal thickness, and dermal/epidermal junction undulations in the skin.
Patent SG-193443-A1 (SG)
Title: Substituted diphenyl derivatives
Inventor: FOERSTER HEINZ
Filed: 2012-03-12
Abstract: Abstract:Triaeene-substituted diphenyl derivatives are suitableas chemotherapeutic agents for treating carcinomas in humans and animals.
Patent SG-194022-A1 (SG)
Title: Garment with cup portions
Inventor: HORII KATSUKO
Filed: 2012-03-23
Abstract: GARMENT WITH CUP PORTIONSThe present invention provides a garment with cup portions, which can reduce the bounce of breasts during exercise effectively, while keeping the shape of the breasts without squashing the breasts when it is worn. In each cup portion 101 of the garment having cup portions, a support member 110 is provided so as to extend along the periphery of the swell of a wearer's breast.10 The support member 110 includes a lower support member 110A and an upper support member 110B. The lower support member 110A is stretchable in a direction connecting the front center side and the lateral side of the cup portion 101. The upper support member 110B is non-stretchable or slightly stretchable in a direction orthogonal to the above-described direction. At least part of a front15 center side-portion and at least part of a lateral side-portion of the upper support member 110B are fixed to the garment. At least part of a lateral side-portion of the lower support member 110A is fixed to the garment so that the lower support member 110A is displaceable relative to the cup portion 101.20 Fig. 1
Patent SG-194659-A1 (SG)
Title: Systems and methods for phlebotomy through a peripheral iv catheter
Inventor: DEVGON PITAMBER
Filed: 2012-04-26
Abstract: An apparatus for performing phlebotomy through a peripheral intravenous line is described herein. The apparatus includes an introducer and a cannula and is configured to advance the cannula through a peripheral intravenous line. A y-adapter with a port of larger diameter is configured to receive the cannula to place the cannula in fluid communication with the peripheral intravenous line. When advanced, the cannula is configured to transport a bodily fluid to a volume outside of the body.
Patent SG-195610-A1 (SG)
Title: Medical device, method and system for temporary occlusion of an opening in a lumen of a body
Inventor: JOENSSON ANDERS
IPC: A61F2/958
Filed: 2009-09-15
Abstract: 5 MEDICAL DEVICE, METHOD AND SYSTEM FOR TEMPORARY OCCLUSION OF AN OPENINGIN A LUMEN OF A BODYA medical system is disclosed that has three basic components; a retractable sheet, a first balloon (10) that has a centrally arranged hollow, and a collapsible/expandable support structure (20) at the hollow. The first balloon (10) is for instance mounted/molded onto the exterior surface of the10 support structure (20). The aggregate of support structure (20) and the first balloon (10) is positioned, and once the sheet has been retracted from the first balloon, the first balloon (10) is inflated. The support structure (20) may be self-expandable or expandable by an expansion unit, such as a further balloon arranged at its inside. The lumen of the support structure (20) is chosen to be smaller than that of a main lumen (80). The outside diameter of the inflated first balloon (10) is chosen to be larger15 than the interior diameter of the main lumen (80). This procedure may be done using standard Seldinger technique and fluoroscopy. This makes the system user friendly and increases patient safety, as a well established clinical method may be used with some modifications according to the invention.: Fig. 4
Patent SG-194878-A1 (SG)
Title: Extracellular matrix material conduits and methods of making and using same
Inventor: MATHENY ROBERT G
Filed: 2012-05-24
Abstract: Extracellular matrix (ECM) material conduits are disclosed. Methods for regenerating atrioventricular valves to replace defective atrioventricular valves within a heart of a subject using the ECM material conduits are also disclosed. Methods of sterilizing and decellularizing an ECM material are also disclosed.
Patent WO-2015002611-A1 (WO)
Title: Compositions et méthodes pour inhiber la thrombogenèse
Inventor: CHEN WAN
IPC: A61K38/17
Filed: 2014-07-01
Abstract: L'invention concerne une composition un ou plusieurs peptides isolés, comprenant un peptide BF01, des variants d'un peptide BF01 et/ou des mutants d'un peptide BF01. Selon des aspects particuliers, la composition est une composition pharmaceutique. La ou les compositions peuvent être utilisées pour inhiber la thrombogenèse, inhiber sélectivement la voie intrinsèque de la coagulation sanguine et inhiber sélectivement FX1 chez un individu ayant besoin d'un tel traitement, par administration d'une quantité efficace d'une partie biologiquement active d'un peptide BF01, d'un ou plusieurs variants correspondants, et/ou d'un ou plusieurs mutants correspondants.
Patent WO-2016114716-A1 (WO)
Title: Diamants monocristallins de qualité électronique et procédé pour les produire
Inventor: DEVI SHANKER MISRA
IPC: C30B29/04
Filed: 2015-12-28
Abstract: L'invention concerne un procédé utilisant le dépôt chimique en phase vapeur par plasma micro-ondes (MPCVD) pour produire un diamant monocristallin de qualité électronique, le procédé comprenant les étapes consistant à : (a) sélectionner un germe de diamant ou un substrat ayant une orientation prédéterminée ; (b) éliminer par nettoyage et/ou décapage les phases non diamant et autres défauts de surface induits sur le germe de diamant ou le substrat, cette étape pouvant être effectuée une ou plusieurs fois ; (c) faire croître une couche de surface diamantée ayant une très faible densité de défauts cristallins sur le germe de diamant ou le substrat nettoyé/décapé, cette étape pouvant être effectuée une ou plusieurs fois ; et (d) faire croître du diamant monocristallin de qualité électronique sur la couche de surface diamantée à faible densité de défauts cristallins.
Patent WO-2016167726-A1 (WO)
Inventor: ZHANG YUGEN
IPC: C07C57/00
Filed: 2016-04-15
Abstract: There is provided a method for synthesizing an alkenoic acid, in particular acrylic acid comprising the step of oxidizing an alkenyl alcohol in the presence of a metal oxide catalyst to form the alkenoic acid. The invention further provides a step of deoxydehydrating a polyol, including glycerol to obtain said alkenyl alcohol including an allyl alcohol.
Patent WO-2019035762-A1 (WO)
Title: Pressure relief mattress and body pressure management system thereof
Inventor: CHEE JOHNNY
IPC: A47C27/08
Filed: 2018-08-03
Abstract: Disclosed herein is a pressure-relief mattress comprising: a plurality of inflatable bladders; a pressure sensor pad arranged to detect pressure exerted on a subject, the pressure sensor pad comprising a plurality of pressure sensor cells being arranged in a matrix with at least one row and at least one column; a pressure-sensing electronic unit electrically connected with the plurality of pressure sensor cells; and a pressure-control electronic unit communicatively connected with the pressure-sensing electronic unit; wherein the pressure-sensing electronic unit is configured for generating a measurement result indicative of a pressure exerted upon the subject at one or more of the pressure sensor cells, the pressure control electronic unit is configured for controlling operation of one or more of the inflatable bladders according to the pressure measurement result.
Patent WO-2019216827-A1 (WO)
Title: A divider and divider plate
Inventor: LAM CHOON SEN DAVID
IPC: B65D25/06
Filed: 2019-05-08
Abstract: The invention relates to an object transport system comprising a divider plate having an array of apertures; and a plurality of dividers, each of said dividers comprising an elongate throat connecting a head to a divider base, wherein the divider base is arranged to be inserted into one of said apertures.
Patent WO-2021126088-A1 (WO)
Title: Optical component
Inventor: PARRA EDGAR A FLORES
IPC: G02B6/42
Filed: 2020-12-18
Abstract: An optical assembly comprising an interdigital capacitor, one or more electrical contacts in electrical connection with the interdigital capacitor and an insulating layer covering at least a portion of the interdigital capacitor. The one or more electrical contacts and a portion of the insulating layer are configured to receive conductive adhesive. The optical assembly further comprises a metallic layer positioned between the interdigital capacitor and the portion of the insulating layer configured to receive the conductive adhesive.
Patent WO-2022173368-A1 (WO)
Title: Module optoélectronique
Inventor: ETSCHMAIER HARALD
IPC: H01L33/58
Filed: 2021-12-21
Abstract: Des modes de réalisation de la présente invention concernent un module optoélectronique, un procédé de fabrication de celui-ci, et un dispositif informatique comprenant le module optoélectronique. Le module optoélectronique comprend : une puce de commande (108) montée sur un substrat (114) ; un émetteur optique (102) monté sur une surface supérieure (204) de la puce de commande ; un élément d'espacement (105) monté sur la surface supérieure de la puce de commande, l'élément d'espacement entourant et définissant une cavité autour de l'émetteur optique ; et un élément optique (111) monté sur une surface supérieure de l'élément d'espacement, l'élément optique étant transparent à la lumière émise par l'émetteur optique et comprenant un élément de verrouillage (113) connecté électriquement à la puce de commande.
Patent WO-2015030686-A1 (WO)
Title: Procédé de mesure de petite capacité dans un circuit
Inventor: MARTINJAK ANTON
IPC: G01R31/27
Filed: 2014-03-25
Abstract: La présente invention concerne un procédé de mesure de petites capacités, comprenant également une résistance connectée en parallèle, à basse fréquence, une mise en œuvre de la mesure à l'aide d'une carte DAQ classique et une utilisation du procédé pour mesurer une caractéristique VI conjointement avec une représentation graphique de résistance dynamique, en particulier de diodes de protection dans un circuit. Le procédé repose sur la mesure d'un changement de décalage de phase dû à la capacité mesurée qui forme un élément RC avec la résistance de mesure, ladite résistance étant couplée entre un générateur et un élément de mesure auquel est liée la capacité mesurée.
Patent TN-2011000197-A1 (TN)
Title: Induction d'une voie de biosynthese cryptique chez la souche de streptomyces sp. tn262 par des cellules fongiques detruites pour la production de la biomolecule derive de diketopiperazine, cyclo (l-leu-l-arg)
Inventor: LOBNA ELLEUCH
IPC: C12N1/00
Filed: 2011-04-20
Abstract: La présente invention concerne l'induction de l'expression d'une voie de biosynthèse cryptique chez la souche de streptomyces sp.TN262. Cette souche a été isolée et sélectionnée dans des travaux antérieurs pour ses capacités d'inhiber la croissance des bactéries a Gram positive et a Gram négative et des champignons. Egalement, lors des travaux antérieurs, treize molécules bioactives pouvant avoir des intérêts thérapeutiques, agricoles et agroalimentaires ont été purifiés et caractérisées chimiquement à partir d'une culture en milieu liquide de la souche de streptomyces sp.TN262. L'originalité des travaux de recherche objet de la présente invention, consiste en l'induction des voies de biosynthèse des biomolécules cryptiques chez les bactéries, ce qui contribuera de façon très efficace à la découverte de nouvelles molécules bioactives par voie naturelle. En effet, nous avons démontré que l'addition, dans le milieu de culture de la souche de streptomyces sp.TN262, de cellules détruites du champignon Fusarium sp., permet l'obtention d'une quatorzième biomolécule en plus des treize biomolécules obtenues dans les conditions standards (sans induction). Cette nouvelle biomolécule a été purifiée et caractérisée chimiquement. Il s'agit d'un dérivé de dikétopipérazine, le cyclo (L-Leu-L-Arg).