baber/WOPTO huggingface dataset:
Patent CY-1119993-T1 (CY)
Title: Εξωθουμενες με τηξη διασπορες στερεου που περιεχουν παραγοντα διεγερσης αποπτωσης
Inventor: RÖSCH Esther
IPC: A61K47/32
Filed: 2017-12-20
Abstract: Μία προ-αποπτωτική διασπορά στερεού περιλαμβάνει, βασικά σε μη-κρυσταλλική μορφή, ανασταλτική ποσότητα πρωτεΐνης οικογένειας Bcl-2 του Τύπου I όπως ορίζεται στο παρόν, διασπαρμένη σε μία στερεά μήτρα που περιλαμβάνει (a) φαρμακευτικώς αποδεκτό υδατοδιαλυτό πολυμερικό φορέα και (b) φαρμακευτικώς αποδεκτό επιφανειοδραστικό. Μία μέθοδος για παρασκευής μιας τέτοιας διασποράς στερεού περιλαμβάνει υποβολή σε αυξημένη θερμοκρασία της ένωσης του Τύπου I, του υδατοδιαλυτού πολυμερικού φορέα και του επιφανειοδραστικού, για να παρέχεται εξωθήσιμο ημι-στερεό μίγμα· εξώθηση του ημι-στερεού μίγματος· και ψύξη του προκύπτοντος εξωθήματος για να παρέχει στερεά μήτρα που περιλαμβάνει τον πολυμερικό φορέα και το επιφανειοδραστικό και που έχει την ένωση διεσπαρμένη σε βασικά μη κρυσταλλική μορφή σε αυτή. Η διασπορά στερεού είναι κατάλληλη για χορήγηση από του στόματος σε ένα υποκείμενο που έχει ανάγκη αυτής, για θεραπεία ασθένειας που χαρακτηρίζεται από υπερέκφραση μιας ή περισσότερων αντι-αποπτωτικών Bcl-2 οικογένειας πρωτεϊνών, για παράδειγμα καρκίνου ή άνοσης ή αυτοάνοσης ασθένειας.
Patent CY-1121547-T1 (CY)
Title: Μη ανθρωπινα ζωα που εχουν ενα εξανθρωποποιημενο γονιδιο συμπλεγματος διαφοροποιησης 47
Inventor: GURER CAGAN
IPC: A01K67/027
Filed: 2019-03-21
Abstract: Παρέχονται μη ανθρώπινα ζώα και μέθοδοι και συνθέσεις για παρασκευή και χρήση αυτών, όπου τα εν λόγω μη ανθρώπινα ζώα περιλαμβάνουν εξανθρωποποίηση ενός ενδογενούς γονιδίου συμπλέγματος διαφοροποίησης (CD), συγκεκριμένα εξανθρωποποίηση ενός γονιδίου CD47. Τα εν λόγω μη ανθρώπινα ζώα μπορούν να περιγραφούν, σε μερικές υλοποιήσεις, ως έχοντα μια γενετική τροποποίηση σε ένα ενδογενές γονίδιο CD47 έτσι ώστε τα εν λόγω μη ανθρώπινα ζώα να εκφράζουν ένα πολυπεπτίδιο CD47 που περιλαμβάνει ένα ανθρώπινο τμήμα και ένα μη ανθρώπινο τμήμα (π.χ., ένα τμήμα ποντικού).
Patent CY-1122582-T1 (CY)
Title: Στερεες μορφες δοσολογιας περιλαμβανουν εντερικη επικαλυψη με επιταχυνομενη απελευθερωση φαρμακου
Inventor: LIU FANG
IPC: A61K9/50
Filed: 2019-12-04
Abstract: Η παρούσα εφεύρεση αναφέρεται σε μια στερεή δοσολογική μορφή που περιλαμβάνει μια εσωτερική επικάλυψη η οποία βρίσκεται μεταξύ ενός πυρήνα που περιέχει ένα φαρμακευτικώς δραστικό συστατικό και μιας εξωτερικής εντερικής επικάλυψης• όπου η εν λόγω εσωτερική επικάλυψη περιλαμβάνει ένα μερικώς εξουδετερωμένο ανιονικό πολυμερές υλικό και τουλάχιστον ένα καρβοξυλικό οξύ που έχει 2 έως 16 άτομα άνθρακα, άλατα αυτών ή μίγματα του εν λόγω οξέος και του άλατος αυτού• όπου η εν λόγω εξωτερική επικάλυψη περιλαμβάνει ένα ανιονικό πολυμερές υλικό το οποίο είναι λιγότερο ή καθόλου εξουδετερωμένο από το υλικό της εσωτερικής επικάλυψης.
Patent GR-940300006-T1 (GR)
Title: Roof blocking bituminous sealing membrane and method for its manufacture.
Inventor: SCHERP ERNST DIPL-ING
IPC: E04D11/00
Filed: 1994-03-31
Abstract: The root-resistant, bituminous sealing membrane with improved flexibility contains, instead of a copper strip, a plastic sheet coated with 0.1 to 3 g/m<2> of copper. In its production in a roof membrane plant, it is also provided with a reinforcing insert comprising a sheet-like fibre structure. If the membrane is produced in a film casting plant, the reinforcing insert can be dispensed with.
Patent HR-P20100320-T1 (HR)
Inventor: BONACCI ENZO
IPC: A47J31/36
Filed: 2010-06-02
Abstract: Uređaj za pripremanje napitka (50) iz supstance prehrambenog proizvoda koja se nalazi u kapsuli (24), pri čemu se u ovu kapsulu (24), koja se nalazi u uređaju (50), dovodi tekućina i pri čemu se navedena tekućina priprema pomoću unutarnjeg ili pomoću vanjskog uređaja za snabdijevanje vodom, pri čemu navedeni uređaj za pripremanje napitka sadržava: glavu za ekstrakciju (20) koja ima otvor (22) za umetanje kapsule (24) u komoru za zakuhavanje (25) uređaja (50), pri čemu je komora za zakuhavanje (25) određena gornjim i donjim elementom koji obuhvaćaju čahuru (10a, 10b), mehanizam za zatvaranje (1), koji selektivno obuhvaća navedenu kapsulu (24) relativnim pomicanjem navedenih elemenata za zatvaranje (10a, 10b), pri čemu su elementi za zatvaranje (10a, 10b) izvedeni tako da pomiču između otvorenog položaja za umetanje kapsule (24) u komoru za zakuhavanje (25) i zatvorenog položaja u kojem položaju je kapsula (24) nepropusno zatvorena unutar komore za zakuhavanje (25), isredstva za namještanje (3a, 3b, 9b, 9c, 7a, 7b, 8a), koja sredstva su spojena na najmanje jedan od navedenih elemenata za zatvaranje (10a, 10b), kako bi se na taj način namjestio relativan položaj elemenata za zatvaranje (10a, 10b), a time i sila kod zatvaranja mehanizma za zatvaranje (1) u zatvoreni položaj, naznačen time što navedena sredstva za namještanje imaju uređaje s ekscentrom (3a, 3b) ili uređaje s bregovima (9b, 9c, 7b) koji omogućavaju mijenjanje sile mehanizma za zatvaranje. Patent sadrži još 19 patentnih zahtjeva.
Patent SI-1770050-T1 (SI)
Title: Foldable crane
Inventor: STEINDL GEORG
IPC: B66C23/00
Filed: 2005-09-29
Abstract: The crane has a crane support, and a hinge arm system (3) having a hub arm (4) and a break arm (5) connected with the arm (4). A hub cylinder is operated between the support and the hub arm, and a break cylinder (7) is operated between the arms. The hub arm has an accommodation section for the break arm in an area of articulation of the hub arm with the break arm, where the distance between the rotary axis of the articulation and a guiding point (11) of the break cylinder at the hub arm is larger than the distance between the axis of the articulation and guiding point (12) at the break arm.
Patent SI-1861360-T1 (SI)
Title: Pyrrolidine derivatives as histamine h3 receptor antagonists
Inventor: BEAVERS LISA SELSAM
IPC: A61K31/00
Filed: 2006-03-13
Abstract: The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
Patent TR-200102815-T1 (TR)
Title: Displazili dokunun tespiti için kullanılacak in vivo lekeleme bileşik ve metodları.
Inventor: BURKETT DOUGLAS D
IPC: A61K31/5415
Filed: 2000-01-31
Abstract: Bu bulus, insanlarda in vivo topikal uygulamalar için uygun yeni biyolojik lekeleme bilesikleri ile ilgilidir.
Patent TR-200600596-T1 (TR)
Title: Bir yıkayıcı/kurutucu
Inventor: KARATAS HAKAN
IPC: D06F58/22
Filed: 2004-08-10
Abstract: Bu buluş, kullanıcının kolayca takıp çıkartarak temizleyebildiği bir lif filtresi (10) içeren bir yıkayıcı/kurutucu (1) ile ilgilidir.
Patent TR-200701612-T1 (TR)
Title: Geliştirilmiş bir yağ jeti içeren bir motor
Inventor: GUERASLAN ERGUEN
IPC: F01M1/08
Filed: 2004-12-17
Abstract: Bu buluş, çeşitli parçalarının özellikle de külbütör fil ayağının yağlanmasını sağlayan bir jet içeren bir motor, özellikle içten yanmalı dizel bir motor ile ilgilidir. Bu amaçla gerçekleştirilen motor temel olarak, yağ kanalının ucuna takılan, iki kademeli, tercihan silindirik bir jet içermektedir. Bu jetin ekseni boyunca uzanan bir ana yağ kanalı bulunmaktadır. Ayrıca, ilk ve daha küçük çaplı kademenin yanal yüzeyinden ana kanala kadar uzanan en az bir tali kan bulunmaktadır. Böylece, ana kanal tıkansa bile tali kanallardan yağ akışı sürmektedir.
Patent DE-3750842-T2 (DE)
Inventor: ISHIGURO MASAJI
IPC: A61P31/04
Filed: 1987-12-24
Granted: 1995-05-18
Abstract: Novel penem compounds of the formula, <CHEM> wherein R is hydrogen or allyl, and A is an aliphatic 5- or 6- membered heterocyclic group having one or two oxygens in the ring and their pharmaceutically acceptable salts are produced from the compounds of the formula, <CHEM> wherein A is as defined above and R<1> and R<2> are respective protective groups for hydroxyl and carboxyl groups, and Z is oxygen, triarylphosphino or trialkylphosphino. The compounds and their salts are useful as antibacterial agents.
Patent DE-3782688-T2 (DE)
Inventor: LARSSON KENNETH LARS
IPC: F16L15/00
Filed: 1987-07-07
Granted: 1993-04-01
Abstract: The present invention refers to a threaded coupling for percussion drill rods having a diameter of 30 - 40 mm, comprising an external rod thread and an internal sleeve thread, the longitudinal section of said threads having continuously curved tops and bottoms. In threads of the type mentioned above it is desirable to be able to tighten them to a relatively high degree because otherwise the thread coupling loosenes when used in hydraulic percussive drilling machines of a high frequency. Significant for the thread coupling of the present invention is that the pitch (S) is 7 - 11 mm, the radii of curvature (R1 - R4), at least for the portions of the tops and bottoms located immediately adjacent the contact shoulder, are 3 - 5 mmm, and that the threads have a height (H1,H2) of 1.2 - 1.6 mm.
Patent DE-3782941-T2 (DE)
Inventor: LOGIN B
IPC: A61K8/46
Filed: 1987-06-15
Granted: 1993-06-03
Abstract: A composition comprising an aqueous preparation on the basis of keratin softening, which contains as a swelling and penetration agent, an N-alkyl pyrrolidone wherein the alkyl group contains between 8 and 22 carbon atoms.
Patent DE-3788989-T2 (DE)
Inventor: SENEZ ALAIN
IPC: C08J5/18
Filed: 1987-08-27
Granted: 1994-05-19
Abstract: A polymer composition comprising (a) 99 to 75 weight percent of LLDPE and (b) 1 to 25 weight percent of a copolymer of propylene (CP) with 7 to 40 weight % of one or more C4 to C12 alpha-olefins and 0 to 10 weight % of ethylene. The propylene copolymer (CP) has a fusion enthalpy not more than 75 J/g. The composition is readily converted into uniform thickness film by extrusion blowing, and exhibits good hot tack strength during heat-sealing operations.
Patent TR-199801083-T2 (TR)
Inventor: ZILCH HARALD
IPC: A61K31/00
Filed: 1996-12-16
Abstract: Bu bulus genel formül I'i haiz fosfonokarboksilik asitlerin yeni lipit türevlerine, (buradaki sembollerin anlamlari tarifnamede açiklanmaktadir), tautomerlerine, fizyolojik olarak tolere edilebilen inorganik ve organik bazli tuzlarina, bunlari üretmeye yönelik islemlere ve bu bilesikleri içeren farmasötik ajanlara iliskindir.
Patent TR-199801930-T2 (TR)
Inventor: LOWE JOHN ADAMS III
IPC: A61K31/44
Filed: 1997-02-17
Abstract: Bu bulus nitrik okit sentaz (NOS) inhibitörü aktivitesi gösteren belirli 6-fenil-piridin-2-ilamin türevleri, bu bilesikleri ihtiva eden farmasötik bilesimler ve bu bilesiklerin merkezi sinir sistemi rahatsizliklarinin tedavisi ve önlenmesinde kullanimlari ile ilgilidir.
Patent TR-199902832-T2 (TR)
Inventor: LAVON GARY DEAN
IPC: A61F13/49
Filed: 1997-03-27
Abstract: Absorbent article (20) having a containment assembly (22) comprising an absorbent core (28) between the top sheet (24) and the back sheet (26). The crotch region has a fluid storage capacity of 49%, pref. 41%, most pref. 23% of the total core ultimate storage capacity, and has a high flux liquid distribution material having a flux at 12.4 cm ranging from >0.075 g/cm2/sec to >0.15 g/cm2/sec. The core may comprise natural fibres such as wood pulp or cellulosic fibres, or synthetic fibres such as surfactant- or silica-treated fibres derived from polyolefins, polyacrylics, polyamides, polystyrenes, polyurethanes, etc.. The fibres may be chemically stiffened, twisted and curled. Alternatively, open-celled absorbent polymeric foam materials derived from HIPE-derived foams may be used or super absorbent polymers may be used.
Patent DE-60001669-T2 (DE)
Inventor: RONCHI DOMENICO
IPC: F23G5/027
Filed: 2000-07-11
Granted: 2003-12-18
Abstract: A process is disclosed for the pyrolysis and gasification of waste materials, in particular of special and/or hazardous waste materials, comprising a gasification and melting step, a step of treatment of the mixture of the obtained gases, and a vitrification step, wherein said steps provide for the following passages: a) the material to be treated, at a temperature comprised between 1300 and 1500° C., is gasified for a lapse of time comprised between 3 and 15 seconds, and melt for a time comprised between 5 and 30 minutes, in total absence of air, obtaining a mixture of combustible gases, non-combustible gases and inert gases, through at least two gasification steps carried out in a sequence, wherein the temperature is maintained constant through the use of at least one thermal lance in any one of the gasification steps; b) the mixture of combustible and non-combustible gases thus obtained is subjected to purification and energy-recovery treatments; c) the inert gases, or inorganic and mineral proportion, are extracted in vitrified state. Further on, a device for carrying out such process is disclosed.
Patent DE-60003074-T2 (DE)
Inventor: DUVOLD TORE
IPC: A61P31/00
Filed: 2000-10-12
Granted: 2004-03-18
Abstract: Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.
Patent DE-60006069-T2 (DE)
Inventor: LULLA AMAR
IPC: A61K47/38
Filed: 2000-02-07
Granted: 2004-07-29
Abstract: Topical medicinal spray composition comprises a volatile vehicle containing one or more medicaments and one or more film forming polymers. The composition can be sprayed on a topical site to form a stable, breathable film from which the medicaments are transdermally available. Independent claims are included for the following: (1) a dispenser containing the above composition which is dispensed as a spray and (2) preparation of an aerosol dispenser which comprises mixing the components of the composition without propellant and charging the obtained mixture with propellant into an aerosol dispenser.
Patent DE-60014667-T2 (DE)
Inventor: OPPONG DAVID
IPC: A01N43/76
Filed: 2000-07-26
Granted: 2005-03-10
Abstract: A method for increasing the effectiveness of the microbicide propiconazole, (RS)-1-2-[(2,4-dichlorophenyl)-2-propyl-1,3-dioxalan-2ylmethyl]-1H-1,2,4-triazole, is described. In the method, propiconazole and a potentiator, an N-alkyl heterocyclic compound, its salt, or a mixture thereof, are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound, its salt, or a mixture thereof is applied in an amount effective to increase the microbicidal activity of the microbicide. The N-alkyl heterocyclic compound has the formula:The variable "n" ranges from 5 to 17, and the heterocyclic ring defined byis a substituted or unsubstituted ring having four to eight members. Microbicidal compositions are described where propiconazole and an N-alkyl heterocyclic compound, its salt, or a mixture thereof are present in a combined amount: effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described. The combination of propiconazole and an N-alkyl heterocyclic compound, its salt, or a mixture thereof is particularly useful as microbicidal in the leather industry, the lumber industry, the papermaking industry, the textile industry, the agricultural industry, and the coating industry, as well as in industrial process waters.
Patent DE-60017386-T2 (DE)
Inventor: RABINER A
IPC: A61N7/02
Filed: 2000-09-29
Granted: 2005-12-29
Abstract: An ultrasonic medical device comprises an ultrasonic vibration generator that generates vibration along its longitudinal axis. The ultrasonic vibration is transmitted through an ultrasonic coupler and a series of transformer sections that amplify the ultrasonic vibration. A flexible member is coupled to the distal end of the transformer sections, and is thus supplied with a longitudinal vibration at its base by the transformer sections. The flexible member is designed so that it converts the longitudinal vibration into a standing wave that runs along the length of the flexible member. The standing wave produces a series of nodes and anti-nodes along the length of the flexible member. Each of the anti-nodes produces cavitation in fluids in contact with the probe. The cavitation of the fluids causes destruction of adjacent tissue. In this manner, the entire length of the flexible member becomes a working surface that may be utilized for destroying tissue.
Patent DE-60021275-T2 (DE)
Inventor: ROSOFF P
IPC: A61M5/28
Filed: 2000-09-07
Granted: 2005-12-22
Abstract: A multiple-dose syringe including a barrel with a closed end and an open end, the closed end having an injection port adapted to receive a needle. A plunger is slidably disposed through the open end of the barrel. A container is connected to an end of the plunger to move with the plunger. The container has a deformable shell with an opening at a forward end thereof and a predetermined quantity of fluid sealed therein by a closure member disposed over the opening. The container is slidably disposed in the barrel and includes a seal proximal to the forward end to form a first cavity in the barrel with a volume that is adjustable by moving the container in the barrel with the plunger so that fluid can be selectively drawn into and expelled from the first cavity. After at least a substantial portion of the fluid is expelled from the first cavity, the shell is configured to be collapsed by further pressure applied by the plunger to expel the predetermined quantity of fluid contained therein.
Patent DE-60023849-T2 (DE)
Inventor: GOBLE COLIN CHARLES OWEN
IPC: A61B18/00
Filed: 2000-03-03
Granted: 2006-08-03
Abstract: An electrosurgery system includes an electrosurgery generator (10) coupled to or part of an electrosurgical instrument, the generator being operable to generate electrosurgical power in low frequency (typically at 1MHz) and high frequency bands (typically at 2.45GHz) either simultaneously or individually. The generator includes a load-responsive control circuit which, in one mode, causes power to be generated predominately at 1MHz when the load impedance is high and predominantly at 2.45MHz when it is low. This allows automatic switching between cutting and coagulation operation. In one embodiment, the instrument includes a gas plasma generator operating such that an ionisable gas is energised in a gas supply passage by the 2.45GHz component to form a plasma stream which acts as a conductor for delivering 1 MHz component to a tissue treatment outlet of the passage.
Patent DE-60027608-T2 (DE)
Inventor: VILLA ROBERTO
IPC: A61K47/36
Filed: 2000-06-08
Granted: 2007-04-26
Abstract: Controlled-release oral pharmaceutical compositions containing as active ingredient 5-amino-salicylic acid, comprising:   a) an inner lipophilic matrix consisting of substances with melting point below 90 DEG C in which the active ingredient is at least partly inglobated; b) an outer hydrophilic matrix in which the lipophilic matrix is dispersed; c) optionally other excipients.mp
Patent DE-60031159-T2 (DE)
Inventor: SETHI ASHOK
IPC: A61C9/00
Filed: 2000-12-15
Granted: 2007-08-23
Abstract: An impression jig assembly for coupling to a bone implant includes a split sleeve having co-axial upper and lower sleeve members, and a fixing screw for clamping the split sleeve to the implant. In use, the fixing screw passes through the split sleeve, and can be withdrawn once impression material has hardened around the assembly to allow the upper sleeve member to separate from the lower sleeve member.
Patent DE-60031249-T2 (DE)
Inventor: BERGER M
IPC: D04H1/42
Filed: 2000-01-18
Granted: 2007-05-24
Abstract: A heat and moisture exchanger including a gas-permeable element, preferably a fibrous media, adapted to be warmed and to trap moisture from a patient's breath during exhalation and to be cooled and to release the trapped moisture for return to the patient during inspiration to effectively conserve the humidity and body heat of the patient's respiratory tract, wherein the media comprises a hydrophilic nylon polymer. The gas-permeable element can be formed entirely of monocomponent fibers of the hydrophilic nylon polymer or, preferably, fibers comprising at least a sheath of the hydrophilic nylon polymer can be bonded at their points of contact by a bonding agent, such as a polyester. Bicomponent fibers comprising a sheath of the hydrophilic nylon polymer can be bonded by other bicomponent fibers comprising a sheath of the bonding agent, with all of the bicomponent fibers comprising a core of a thermoplastic polymer, such as polypropylene, to minimize the cost and increase the strength of the heat and moisture exchanger element.
Patent DE-60036252-T2 (DE)
Inventor: OTSUKA HISATOSHI
IPC: G03F1/60
Filed: 2000-07-07
Granted: 2008-06-05
Abstract: A synthetic quartz glass member having (i) a change of transmittance at 193 nm of up to 0.002 cm<-1> as expressed in extinction coefficient when 4x10<4> shots of ArF excimer laser light are irradiated at 2 mJ/cm<2>/pulse, (ii) an initial transmittance of at least 99.6% at 193 nm, (iii) a hydrogen molecule content of at least 5x10<17> molecules/cm<3>, (iv) a refractive index amplitude of up to 1x10<-6>, and (v) a birefringence of up to 1 nm/cm finds use in an excimer laser because it experiences a minimized change of light transmittance.
Patent DE-60038729-T2 (DE)
Inventor: SABIN CULLEN M
IPC: F25B39/02
Filed: 2000-02-24
Granted: 2009-07-02
Abstract: Portable refrigeration devices (1) including methods for preparing sorbents (30) for use in such devices, and the sorbents (30) prepared in this way. The methods relate to the substantially complete degassing for the maximization of receiving refrigerant vapor from the evaporator chamber (10) of such refrigeration devices (1), and the maximization of heat transfer to heat sink materials (40) in such refrigeration devices (1).
Patent DE-60106838-T2 (DE)
Inventor: ZORICH ROBERT SAM
IPC: B08B9/027
Filed: 2001-09-28
Granted: 2005-04-14
Abstract: The present invention is a process for cleaning a manifold which delivers high purity source chemical from a high purity source chemical container to a point of use after delivery of the high purity source chemical through the manifold is discontinued, comprising; evacuating the manifold by connection to a source of vacuum, terminating the evacuation, introducing at least one solvent for the high purity source chemical into the manifold from at least one source of the at least one solvent, dissolving any residual high purity source chemical in the manifold into the at least one solvent, venting a resulting mixture of residual high purity source chemical and solvent from the manifold, purging such as by pressurizing the manifold by connection to a source of preferably elevated pressure inert gas and terminating the purging i.e. pressurizing, before reintroducing high purity source chemical into the manifold.
Patent DE-60107227-T2 (DE)
Inventor: SHI NIAN-QING
IPC: C12P7/10
Filed: 2001-04-18
Granted: 2005-12-01
Abstract: Disclosed is a SHAM-sensitive terminal oxidase (STO) gene from the xylose-fermenting yeast Pichia stipitis. Also disclosed is a mutant of Pichia stipitis in which the STO gene natively present in the wild-type yeast was disrupted. Mutants of Pichia stipitis having reduced expression of PsSTO were found to exhibit enhanced fermentation of xylose to ethanol.