baber/WOPTO huggingface dataset:
Patent AU-2021250861-A1 (AU)
Title: Medical luer connector
Inventor: BONALDO JEAN
IPC: G16H20/70
Filed: 2021-10-12
Abstract: MEDICAL LUER CONNECTOR 
ABSTRACT 
A medical connector assembly (1) having a longitudinal axis, comprising: a male luer 
body (10) having a proximal end (12), a distal end (14), and a flow channel extending between 
said proximal end (12) and distal end (14), said distal end (14) comprising a tapered male luer 
member (20) having an open end adapted to be connected to a fluid conduit; a female luer 
assembly (105), comprising: a female luer body (100) having a proximal end (102), a distal end 
(104), and a flow channel extending between said proximal end (102) and distal end (104), said 
proximal end (102) of said female luer body (100) forming a female luer member for receiving a 
male luer member of a fluid transfer device; a fluid channel insert (150) having a proximal end, 
a distal end, and a flow channel extending between said proximal end and distal end, wherein 
said flow channel of said fluid channel insert (150) is offset from said longitudinal axis at said 
distal end of said insert, said fluid channel further comprising a distal annular rim at its distal 
end, said annular rim engaging said distal end of said female luer body (100); an elastomeric seal 
(170) having a proximal end, a distal end, and a flow channel extending between said proximal 
end and distal end, wherein said flow channel of said seal is offset from said longitudinal axis at 
said proximal end and is adapted to provide fluid communication with said flow channel of said 
fluid channel insert (150) at said distal end of said fluid channel insert (150); and an elastomeric 
stopper (160) having a proximal end and a distal end, said stopper (160) having a flush surface at 
its proximal end, said flush surface comprising a slit to allow an opening to be formed by 
deforming said proximal end, further comprising an annular groove adapted to mate with said 
medial annular projection of said fluid channel insert (150), wherein said distal end of said 
female luer assembly (105) connects with said proximal end male luer body with an interference 
fit and form a flow channel through said medical connector assembly when said flow channels 
are aligned.
Patent AU-2021251304-A1 (AU)
Title: Neural network weight distribution from a grid of memory elements
Inventor: SAWADA JUN
IPC: G06F17/16
Filed: 2021-01-28
Abstract: Neural inference chips for computing neural activations are provided. In various embodiments, a neural inference chip comprises at least one neural core, a memory array, an instruction buffer, and an instruction memory. The instruction buffer has a position corresponding to each of a plurality of elements of the memory array. The instruction memory provides at least one instruction to the instruction buffer. The instruction buffer advances the at least one instruction between positions in the instruction buffer. The instruction buffer provides the at least one instruction to at least one of the plurality of elements of the memory array from its associated position in the instruction buffer when the memory of the at least one of the plurality of elements contains data associated with the at least one instruction. Each element of the memory array provides a data block from its memory to its horizontal buffer in response to the arrival of an associated instruction from the instruction buffer. The horizontal buffer of each element of the memory array provides a data block to the horizontal buffer of another of the elements of the memory array or to the at least one neural core.
Patent AU-2021258014-A1 (AU)
Title: Electrolysis arrangement and method
Inventor: COMBES GARY
IPC: C25B15/02
Filed: 2021-10-28
Abstract: Electrolysis arrangement (1) comprising: 
- a pump unit (2), 
- multiple stacks (3), 
- a respective control valve (8) for each of the stacks (3), 
- an anode separator (9), and 
- a cathode separator (13).  
Due to the control valves (8) assigned to each of the stacks (3) an independent flow control can 
be achieved for the stacks (3). This allows safe and reliable operation of the electrolysis 
arrangement (1), although multiple stacks (3) are connected to the same anode separator (9) and 
to the same cathode separator (13).
1/2 
181 01 
232 
26 
1115A 20 
14 
163 
2 
84a 6 
24 
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5 AL -
Fi.3
Patent AU-2021262800-A1 (AU)
Title: Nicotine replacement therapy smart device
Inventor: MELLINGER JUSTIN
IPC: A61M15/00
Filed: 2021-04-29
Abstract: A device for providing nicotine replacement therapy may be provided. The device may comprise a dispenser for dispensing a nicotine formulation. The device may comprise an actuating member mounted to actuate the dispenser. The device may comprise a lockout mechanism that may be movable between an operative position that may allow the actuating member to move so as to actuate the dispenser, and a non-operative position that may prevent the actuating member from moving. The device may comprise a processor. The processor may be configured to determine an amount of nicotine that was previously consumed by a user. The processor may be configured to send a lockout mechanism signal to the lockout mechanism that causes the lockout mechanism to move to the non- operative position.
Patent AU-2021289351-A1 (AU)
Title: Catheter with variable length extension leg
Inventor: THORNLEY KYLE G
IPC: A61M25/00
Filed: 2021-06-08
Abstract: A catheter assembly for organizing a catheter system is disclosed. The catheter assembly can include a molded hub, a catheter tube coupled to a distal end of the molded hub, a plurality of extension legs having distal ends coupled to the molded hub, and a securing mechanism. The molded hub can include a pair of hub lumens forming a hub portion of a pair of fluid pathways through the catheter assembly. The catheter tube can include a pair of catheter tube lumens. The securing mechanism can be configured to secure the plurality of extension legs together. The securing mechanism can be in the form of a slidable collar including a proximal opening and distal opening, wherein the slidable collar is positioned over the plurality of extension legs.
Patent AU-2021292561-A1 (AU)
Title: Compositions for solubilizing water-insoluble active ingredients
Inventor: CHAVAN NEHA
IPC: A61K47/10
Filed: 2021-06-17
Abstract: The present invention provides compositions for solubilizing water-insoluble and poorly water-soluble or poorly permeable active ingredients such as drugs, nutritional supplements, and essential oils. The compositions are useful for administration of the active ingredient to the subject via various routes and provide good bioavailability of the active. The compositions are generally clear and non-turbid and are useful, for example, for preparing formulations of cannabinoid compounds.
Patent AU-2021294360-A1 (AU)
Title: Amplicon Comprehensive Enrichment
Inventor: ZHANG DAVID
IPC: C12Q1/6832
Filed: 2021-06-25
Abstract: Provided herein are reagents and methods for comprehensively enriching potential variants within targeted regions, named Amplicon Comprehensive Enrichment (ACE). The sequence variants enriched can include single nucleotide polymorphisms (SNPs), single nucleotide variants, or small insertions and deletions. Embodiments include procedures for integration with real-time polymerase chain reaction, next generation sequencing (NGS), and long-read sequencing.
Patent AU-2021316104-A1 (AU)
Title: Compositions including solid forms of polypeptides and related methods
Inventor: DOYLE PATRICK S
IPC: A61K47/69
Filed: 2021-07-30
Abstract: Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.
Patent AU-2021327110-A1 (AU)
Title: Water soluble container containing dye and method for producing a dyed, aqueous alkali metal cyanide solution
Inventor: SILL TORSTEN
IPC: C09B67/02
Filed: 2021-08-17
Abstract: The invention relates to a water soluble container which is suitable for receiving an additive substance or a additive substance composition and is filled with an additive substance or an additive substance composition comprising at least one dye or at least one dye composition, wherein the water soluble container has a wall thickness in the range from 5 to 50 pm, and wherein the water soluble container comprises a water soluble polymer composition or consists of a water soluble polymer composition, which comprises: • a) at least one polyvinyl alcohol copolymer Pl having a degree of hydrolysis in the range from 75 to 95 Mol%, and/or • b) at least one polyvinyl alcohol P2 having a degree of hydrolysis in the range from 87 to 95 Mol%.
Patent AU-2021340623-A1 (AU)
Title: Polyvalent STING activating compositions and uses thereof
Inventor: GAO JINMING
IPC: A61K31/70
Filed: 2021-09-08
Abstract: Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.
Patent AU-2021366390-A1 (AU)
Title: Apparatus, system, and methods for handling labware
Inventor: EVERS-STAPLES BEN
IPC: B01L9/00
Filed: 2021-10-19
Abstract: An apparatus configured to complementarity engage a pipetting head of a liquid handling system such that movement of the pipetting head effects a corresponding movement of the apparatus. The apparatus includes at least one engagement feature that is configured to mechanically and releasably engage a surface of a lab ware item as a means of releasably coupling the labware item to the apparatus. The labware item has at least one complementary engagement feature and optionally at least one release feature. With the labware item secured within a receptacle, the apparatus can translate relative to the labware item so that the engagement features of the apparatus are in engagement with the release features of the labware item, thereby permitting release of the labware item upon movement of the apparatus relative to the labware item.
Patent AU-2021377201-A1 (AU)
Title: Virtual eye contact in video interaction
Inventor: BARRETT GRAHAM
IPC: H04N7/15
Filed: 2021-11-15
Abstract: Among other things, a first video is captured of at least the eyes of a first person who is looking along a video capture axis. A second video of at least the eyes of a second person is presented, along a display axis. The video capture axis and the display axis are aligned along a common axis so that the first person can view the second video of at least the eyes of the second person along the common axis when the first video of the eyes of the first person is being captured along the common axis. Instructions are executed to maintain an eye contact video interaction session between the first person and the second person using the captured video and the presented video.
Patent AU-2021380919-A1 (AU)
Title: Methods and systems for reuse of data item fingerprints in generation of semantic maps
Inventor: DE SOUSA WEBBER FRANCISCO
IPC: G06F16/35
Filed: 2021-11-18
Abstract: A method for using distributed representations of data items within a first set of data documents clustered in a first two-dimensional metric space to generate a cluster of distributed representations in a second two-dimensional metric space includes clustering in a first two-dimensional metric space, by a reference map generator, a set of data documents, generating a semantic map. A parser generates an enumeration of data items occurring in the set of data documents. A representation generator generates a distributed representation using occurrence information about each data item. A sparsifying module receives an identification of a maximum level of sparsity and reduces a total number of set bits within the distributed representation. The reference map generator clusters, in a second two-dimensional metric space, a set of SDRs retrieved from the SDR database and selected according to a second at least one criterion, generating a second semantic map.
Patent AU-2021401184-A1 (AU)
Title: Composite material, method for manufacturing same, and biological implant
Inventor: HASHIDA MASAHIKO
IPC: A61L27/30
Filed: 2021-12-01
Abstract: Provided is a composite material which has excellent antibacterial properties and which has reduced elution of fluorine. A composite material according to the present disclosure comprises a base material and a surface layer which is located on a surface of the base material. The surface layer contains a compound of titanium and fluorine and a compound of titanium, fluorine, and oxygen. In the surface layer, the amount of the compound of titanium and fluorine does not exceed the amount of the compound of titanium, fluorine, and oxygen.
Patent AU-2021409801-A1 (AU)
Title: Protease-activating cd45-gate car
Inventor: LANG SHANSHAN
IPC: C12N9/16
Filed: 2021-12-21
Abstract: A reversibly gated effector polypeptide e.g. a chimeric antigen receptor (protease-activating CD45-gate CAR) comprising an extracellular CD45 recruiting domain, a protease-cleavable linker, and a polypeptide comprising an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain. Nucleic acids including vectors and expression vectors that encode the protease-activating CD45-gate CAR and cells including immune cells such as T cells that comprise and express the nucleic acids. Methods of treatment of various conditions including various forms of cancer comprising administering the cells including CAR T cell therapy. In some embodiments, the CD45 gate at least partially inhibits activation of the protease-activating CD45-gate CAR when the protease-activating CD45-gate CAR binds antigen. The inhibition is at least partially diminished, relieved and/or eliminated when the protease-activating CD45-gate CAR is exposed to a protease that can cleave the linker.
Patent AU-2021445820-A1 (AU)
Title: CELL STRAIN FOR TGFβ DETECTION AND HIGH-PRECISION TGFβ DETECTION METHOD
Inventor: ZHU HONGJIAN
IPC: C12N5/09
Filed: 2021-05-21
Abstract: Provided are a cell strain for TGFβ detection and a high-precision TGFβ detection method. Specificalla y, the cell strain for TGFβ detection in human samples is created by screening human cells with a TGFβ response at least 300 times. The method can be used for detecting the human samples and is not affected by the human samples. Compared with an ELISA detection method, the sensitivity is increased 30-fold, and a TGFβ content of 1 pg/ml can be detected; and at the same time, the method of the invention has a high selectivity and high reliability for detecting molecules. Moreover, the high accuracy and reproducibility of the above method have been confirmed by a large number of tests carried out on a cell culture medium, mouse serum, human serum and plasma.
Patent AU-2022200233-A1 (AU)
Title: Compositions and methods related to scavenger particles
Inventor: HAWTHORNE LOUIS
IPC: A61K38/19
Filed: 2022-01-14
Abstract: The disclosure provides, among other things, compositions that bind to and inhibit the 
5 biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof.  
The compositions may comprise a plurality of particles that specifically bind a target, such as 
a soluble biomolecule or a biomolecule on the surface of a pathogen, to inhibit the target (or 
pathogen) from interacting with other molecules or cells. Also provided herein are a number 
of applications (e.g., therapeutic applications) in which the compositions are useful.  
10
Patent AU-2022200375-A1 (AU)
Title: Temporal optimization of data operations using distributed search and server management
Inventor: FALCAO ERIC
IPC: G06F16/00
Filed: 2022-01-20
Abstract: Various techniques for temporal optimization of data operations using distributed search and server 
management are described, including configuring a host group using a manifest file, receiving a data file 
at a platform using an application programming interface, parsing the data file to generate a processed 
5 data file, the processed data file having a time characteristic associated with the data file, storing the data 
file at a location by comparing the time characteristic to the time range to determine the class, the server 
type, and the server on which to store the data file, reconciling the host group to determine whether the 
data file has changed, and modifying the data file by performing a data operation on the data file if the 
reconciling indicates the data file has changed.  
0
Patent AU-2022203195-A1 (AU)
Title: Mnd promoter chimeric antigen receptors
Inventor: FRIEDMAN KEVIN
IPC: C07K14/705
Filed: 2022-05-12
Abstract: The invention provides vector compositions for delivering improved adoptive T cell 
therapies.
Patent AU-2022204936-A1 (AU)
Title: Sprayer boom recirculation and mixing systems and methods for same
Inventor: MICHAEL NICHOLAS O
IPC: A01C15/00
Filed: 2022-07-11
Abstract: A product dispensing system includes at least one recirculation network 
configured for communication with a system pump. The at least one 
recirculation network includes at least one sprayer boom tube and a plurality of 
product dispensers distributed along the at least one sprayer boom tube. A 
network pump is in communication with the at least one sprayer boom tube. The 
at least one recirculation network includes a dispensing configuration and a 
recirculation configuration. In the dispensing configuration the recirculation 
network is configured for communication with a supply tank and an agricultural 
product reservoir. In the recirculation configuration the recirculation network is 
isolated from the supply tank and the agricultural product reservoir, and the 
recirculation network includes a recirculation loop continuously extending 
through the network pump and the at least one sprayer boom tube.  
Fig 4A.
WO 2020/102600 PCT/US2019/061563 
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Patent AU-2022243501-A1 (AU)
Title: Riser clamp
Inventor: JOHNSEN JOHN MAGNE
IPC: E21B17/01
Filed: 2022-03-22
Abstract: A riser damp for supporting fluid pipes in parallel with and spaced from an external surface of a tubular riser, the riser damp comprising a body portions which forms a generally circular or part circular damp body which encircles a damp axis, the or each body portion having a radially outwardly facing external surface and a radially inwardly facing internal surface, the riser clamp further comprising a separate generally planar pipe saddle part which extends radially outwardly of the clamp body.
Patent AU-2022248566-A1 (AU)
Title: Treatment of the central nervous system
Inventor: KVÅLE SVEIN
IPC: A61K41/00
Filed: 2022-03-30
Abstract: The present invention relates to ultrasound mediated delivery of therapeutic agents to the central nervous system (CNS). Thus, the invention provides a cluster composition and a pharmaceutical composition, for use in delivery of therapeutic agents to the brain and spinal cord for treatment. The invention further provides compositions and methods to increase permeability of the blood-brain barrier for passage of therapeutic agents to allow for medical treatment of diseases, disorders and injuries of the CNS.
Patent AU-2022255044-A1 (AU)
Title: Methods and systems for sterilization
Inventor: SHODDER PHILIP
IPC: A61L2/20
Filed: 2022-03-30
Abstract: A sterilization method comprising: pre-conditioning a sterilization apparatus including a sterilization chamber (102) comprising a sterilization load (105), wherein pre-conditioning the sterilization apparatus includes increasing a temperature of a portion of the sterilization apparatus to a temperature greater than a maximum temperature of the sterilization load; executing a sterilization phase (206), wherein the sterilization phase (206) includes a plurality of sterilization pulses (420, 440, 460); and executing an aeration phase (208), wherein the aeration phase (208) includes a plurality of aeration pulses, wherein the plurality of aeration pulses includes: a primary aeration pulse comprising: achieving a first vacuum pressure (342) within the sterilization chamber (102), wherein the first vacuum pressure is less than 650 millibar; and after a first vacuum hold (344), increasing the pressure (346) of the sterilization chamber (102) to a pressure greater than 700 millibar; and a secondary aeration pulse comprising: achieving a second vacuum pressure (322) within the sterilization chamber (102), wherein the second vacuum pressure is less than 650 millibar; and after a second vacuum hold (324), adding air (326)to the sterilization chamber (102) while exhausting (328) the sterilization apparatus.
Patent AU-2022271442-A1 (AU)
Title: Lock devices, systems and methods
Inventor: TELLJOHANN BRIAN A
IPC: E05B47/06
Filed: 2022-11-17
Abstract: Disclosed are various embodiments of lock devices, systems, and methods, lock of the application can 
include an internal mechanism to permit backdriven operation and lost motion operation. In one form 
the lock can be made from an assembly of parts that have locating features that require one way 
installation/assembly. The lock can include an internal power source capable of driving electronics 
used to determine handedness of a door.
Patent AU-2022279374-A1 (AU)
Title: Improved immunoglobulin variable domains
Inventor: BUYSE MARIE-ANGE
IPC: C07K16/28
Filed: 2022-11-28
Abstract: : 
VH domain, in which: (i) the amino acid residue at position 1 12 is one of K or Q; and/or (ii) 
the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is 
L and the amino acid residue at position 1 10 is one of K or N Q; and (iv) in each of cases (i) 
to (hi), the amino acid at position 11 is preferably V; and in which said VH domain contains a 
C-ter minal extension (X)n, in which n is I to 10, preferably I to 5, such as 1, 2, 3, 4 or 5 
(and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino 
acid residue that is independently chosen, and preferably independently chosen from the 
group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I)
Patent AU-2022283737-A1 (AU)
Title: Defined multi-conjugate oligonucleotides
Inventor: HADWIGER PHILIPP
IPC: C12N15/11
Filed: 2022-12-08
Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and 
compositions. For example, in various embodiment, defined multi-conjugate 
oligonucleotides can have advantageous properties, for example in the form of defined 
multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced 
intracellular delivery and/or multi-gene silencing effects. In various embodiment, the 
defined multi-conjugate oligonucleotides can be synthesized via new synthetic 
intermediates and methods. The defined multi-conjugate oligonucleotides can be used, 
for example, in reducing gene expression, biological research, treating or preventing 
medical conditions, or to produce new or altered phenotypes in cells or organisms.  
1 id