Patent SG-11201901125T-A (SG)
Title: Treatment of dementia
Inventor: WISCHIK CLAUDE MICHEL
IPC: A61P25/28
Filed: 2017-08-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111 010 1111 001110 11111111111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/041739 Al 08 March 2018 (08.03.2018) WI P0 I P C T (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every A61K 31/5415 (2006.01) A61K 31/55 (2006.01) kind of regional protection available): ARIPO (BW, GH, A61K 45/06 (2006.01) A61K 9/20 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, A61K 31/136 (2006.01) A61K 9/48 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, A61K 31/165 (2006.01) A61P 25/28 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 31/445 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/EP2017/071437 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 25 August 2017 (25.08.2017) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (25) Filing Language: English (26) Publication Language: English Published: — with international search report (Art. 21(3)) (30) Priority Data: 1614834.8 01 September 2016 (01.09.2016) GB (71) Applicant: WISTA LABORATORIES LTD. [SG/SG]; 25 Bukit Batok Crescent, The Elitist #06-13, Singapore 658066 (SG). _ (71) Applicant (for MG only): HARRINGTON, Charles — Robert [GB/GB]; WisTa Laboratories Ltd., Institute of = Medical Sciences, Forresterhill, Aberdeen Aberdeenshire = AB25 2ZD (GB). Inventors: WISCHIK, Claude Michel; c/o WisTa Lab- (72) = oratories Ltd., Institute of Medical Sciences, Forresterhill, _= = Aberdeen Aberdeenshire AB25 2ZD (GB). SCHELTER, Bjorn Olaf; c/o University of Aberdeen, Institute for Corn- _ = plex Systems and Mathematical Biology, Meston Walk., Aberdeen Aberdeenshire AB24 3UE (GB). WISCHIK, Damon Jude; c/o Cambridge Big Data, Cavendish Labo- ratory, J.J. Thomson Avenue, Cambridge Cambridgeshire — = CB3 OHE (GB). STOREY, John Mervyn David; c/o WisTa Laboratories Ltd., Department of Chemistry, Meston = — = Walk, Old Aberdeen Aberdeenshire AB24 3UE (GB). — — Agent: KREMER, Simon et al.; Mewburn Ellis LLP, City (74) Tower, 40 Basinghall Street, London Greater London EC2V = 5DE (GB). = = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, — AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, — 1-1 01 M KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, IN TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 71' 0 00 (54) Title: TREATMENT OF DEMENTIA 1-1 0 (57) : The invention describes improved treatments for Frontotemporal dementia based on the use of a methylthioninium ei compound in combination with a compound which directly modifies synaptic neurotransmission in the brain, such as a symptomatic 0 Alzheimer's disease treatment (e.g. acetylcholinesterase and/or memantine).