baber/WOPTO huggingface dataset:
Patent JP-2716099-B2 (JP)
IPC: A61K31/44
Filed: 1987-07-15
Granted: 1998-02-18
Abstract: There are described compounds of the formula <CHEM>  where (a) X is O or S; (b) R is H, loweralkyl, <CHEM> where Y is O or S; R2 is loweralkyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl, arylloweralkyl, heteroaryl or heteroarylloweralkyl, R3 is H or lower alkyl or the group -NR2R3 taken as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl, 4-methyl-1-piperazinyl or 2-(2,6-dichlorophenylimino)-1-imidazolidinyl) and R4 is hydrogen, loweralkyl, arylloweralkyl, diarylloweralkyl, aryl or heteroaryl, (c) m is 1 or 2; (d) each Z is independently H, loweralkyl, halogen, nitro, -NH2, loweralkylcarbonylamino, arylcarbonylamino, loweralkoxycarbonylamino or loweralkylamino, and (e) R1 is H, loweralkyl, arylloweralkyl, heteroarylloweralkyl, cycloalkylmethyl or loweralkenylmethyl, with the proviso that when X is O, m is 1, Z is H and R1 is methyl, R is not -CONHCH3, -CONHC6H5, hydrogen, methyl or ethyl, and that when X is O, m is 1 and Z and R are both hydrogen, R is not hydrogen or methyl, and pharmaceutically acceptable acid addition salts thereof which are useful as memory-enhancing and analgesic agents.
Patent JP-H0414680-B2 (JP)
IPC: C07J53/00
Filed: 1984-09-07
Abstract: A multistep process for production of 17 alpha -acetoxy-1,2-methylene-4,6-pregnadiene-3,20-dione involves ketalization of the 20-keto group of 17 alpha -hydroxy-1,4,6-pregnatriene-3,20-dione, then methylenation in the 1,2-position with trimethylsulfoxonium iodide, hydrolysis and simultaneous acetylation of the 17 alpha -hydroxy group.
Patent JP-H0690204-B2 (JP)
IPC: C12P21/00
Filed: 1985-08-27
Abstract: This invention relates to the use of a specific tumor associated antigen of carbohydrate nature, sialosyllactotetraose-(IV<3>NeuAcLcOse4) for diagnostic and therapeutic procedures related to human tumor diseases.
Patent JP-H022879-B2 (JP)
IPC: C09B29/34
Filed: 1981-12-02
Abstract: Compounds of formula (I)   <IMAGE> (I)  in which n is 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R2 is an immunogenic determinant and x is 1 or 2, provided that when n is 1, x is 1 or 2 and there is one diazo moiety at the 3-position or two diazo moieties at the 3- and 5-positions, with respect to the isothiocyanate group, and the hydroxy group is at the 4-position; and provided that when n is 2, x is 1 and the diazo moiety is at the 4-position and the hydroxy groups are at the 3- and 5-positions, are described. The compounds are useful in the preparation of immunoglobulin conjugates for employment in diagnostic techniques.
Patent JP-2696972-B2 (JP)
IPC: G05B13/02
Filed: 1988-08-18
Granted: 1998-01-14
Abstract: Applicable rules (IF-THEN rules) are generated with use of predetermined membership functions concerning input and output variables in response to entry of input and output values. Accordingly, time and labor required to make rules can be simplified. In addition, it can be also verified, by making fuzzy inferences according to the generated rules, whether or not the rules are appropriate.
Patent JP-3600642-B2 (JP)
IPC: C04B41/50
Filed: 1994-09-01
Granted: 2004-12-15
Abstract: In order to manufacture lightweight mirror structures or other reflecting assemblies, there are applied, to a porous carbon supporting framework (CFC or CMC) having the dimensions of the assembly to be manufactured, shaped parts made of silicon and having an adequate wall thickness, at temperatures between 1300 DEG C and 1600 DEG C in vacuo or in a protective gas (inert gas) atmosphere, which directly results in the formation of mirror structures or reflectors. It is possible to operate at temperatures of 300-600 DEG C if the shaped parts made of silicon, especially wafers, are bonded to the supporting framework via a zone of a melt eutectic, introducing a non-ferrous metal, especially gold. Finally the surfaces are coated. <IMAGE>
Patent JP-H0810009-B2 (JP)
IPC: F16C33/22
Filed: 1989-09-22
Abstract: An extrudable multi-durometer hydrodynamic bearing which includes a bearing pad support structure (10) and a plurality of bearing pads (50) fused to the bearing pad support structure (10). The bearing may also include a number of deflection control members (80) fused to the bearing pads and/or the bearing pad support structure. The pad supports of the bearing and movable with six degrees of freedom. The bearing is constructed entirely of non-newtonian fluidic materials and has a constant axial cross-section so that it may be easily extruded. The bearing includes portions having different hardnesses. The method of making the bearing includes the steps of extruding a first material, extruding at least a second material onto the first material prior to curing the first material forming a tubular extrusion, curing the tubular extrusion, cutting the tubular extrusion into bearing segments and sizing the bearing segments by machining the individual bearing segments to the desired inner and outer diameters.
Patent JP-2561326-B2 (JP)
IPC: A47G9/06
Filed: 1988-10-04
Granted: 1996-12-04
Abstract: A thermal blanket (10) includes an inflatable covering with a head end (12), a foot end (14), two edges (15) and an undersurface. The covering is inflated through an inlet (16) at the foot end (14) by a thermally-controlled inflating medium. An aperture array on the undersurface of the covering exhausts the thermally-controlled inflating medium from the covering. Exhaust port openings (23) are provided at the edges (15) of the covering to vent the inflating medium, which enhances circulation of the thermally-controlled medium through the cover. An uninflatable section (22) is provided at the head end (12), together with an absorbent bib (24) attached to the covering, adjacent the uninflatable section (22). When inflated, the thermal blanket (10) self-erects and provides a bath of thermally-controlled inflating medium to the interior of the erected structure. The enhanced circulation of the medium through the covers maintains a relatively high average temperature under the blanket (10) and a relatively uniform distribution of temperature in the inflating medium which is exhausted through the apertures into the structure's interior. When the structure covers a patient, the uninflatable section (22) provides a relatively unobstructed view of the patient's face, while the absorbent bib (24) maintains a relatively sanitary environment in the area beneath the patient's head.
Patent JP-3237923-B2 (JP)
IPC: G01N33/96
Filed: 1992-10-13
Granted: 2001-12-10
Abstract: The invention relates to artificial standard and control reagents for use in immunochemical detection methods and to processes for preparing these reagents.
Patent JP-4223107-B2 (JP)
IPC: G02F1/1333
Filed: 1998-10-09
Granted: 2009-02-12
Abstract: PROBLEM TO BE SOLVED: To carry out optical modulation without need of a gap forming process for filling a liquid crystal, enabling the structure having a uniform and large area without formation of orientation defects, and attaining improved strength against the outer stress, a high speed and high contrast. SOLUTION: The modulator has a liquid crystal-resin composite 3 composed of a ferroelectric liquid crystal 1 having a spontaneously polarizable characteristics and exhibiting a chiral smectic C phase and a three-dimensional reticular synthetic resin 2, two transparent substrates 5a, 5b on each of which a transparent electrode 4a or 4b is formed and which hold the liquid crystal-resin composite 3 between them in such a manner that the transparent electrodes 4a, 4b are each interposed inside each of the transparent substrates 5a, 5b and allowed to stick to the liquid crystal-resin composite 3, and a power source 8 for applying the direct current voltage having both polarities to the two transparent electrodes 4a, 4b.  It becomes unnecessary to control the gap using a seal resin and becomes possible to produce the optical modulator having a uniform and large area by forming the firm liquid crystal-resin composite 3 by dispersing the synthetic resin 2 into the low molecular weight ferroelectric liquid crystal 1 in a high concentration and coating the mixture thus obtained on the transparent electrodes 4a, 4b with the liquid, each being formed on the transparent substrates 5a, 5b.
Patent JP-H0455342-B2 (JP)
IPC: H01L27/04
Filed: 1985-12-24
Abstract: An integrated circuit includes capacitances of different capacitance values, this circuit having rows of basic capacitances, while the capacitances have different numbers of basic capacitances connected in parallel between a first connection electrode and an associated second connection electrode. Plural rows have the same number of n basic capacitances and in different ones of these rows different numbers of basic capacitances form part of the capacitances, all the remaining basic capacitances of the relevant rows being dummy capacitances. The second capacitance electrodes are connected to one or more further connection electrodes.
Patent JP-H0740929-B2 (JP)
IPC: C12M3/00
Filed: 1988-11-22
Abstract: In order to obtain cell cultures in relatively large quantity, it is necessary to detach the cultures in each case from the microcarriers and transfer them to unoccupied microcarriers. To date this has been carried out intermittently by adding trypsin, which causes detachment of the cells, to a container with colonised microcarriers. A high percentage of the cells detaches rather rapidly and thus remains a long time in the trypsin solution, which has an adverse effect on these cells. 
<??>In the process, the trypsin solution is passed in a continuous flow process through the container and thus through the microcarriers. Detached cells are therefore immediately flushed out of the container, and the trypsin solution is inactivated and/or separated out after leaving the container. 
<??>The process can be used for growing cell cultures on microcarriers. 
<IMAGE>
Patent JP-2736929-B2 (JP)
IPC: B60D1/50
Filed: 1989-12-01
Granted: 1998-04-08
Abstract: In a known device, an electrical contact is closed when an elastomer spring element associated with the drawbar coupling has sprung in to a prescribed extent or more under the action of the axial force. Upwards of the specific magnitude of the axial force, the device thus indicates only that such a force exists at all. This device is not suitable for applications in which the magnitude of the axial force is at issue. 
<??>In order to avoid this disadvantage, the invention proposes to measure the pressure produced by the axial force in the elastomer spring element and for this purpose to arrange a pressure sensor (2; 18 or 7) on a transfer shoulder (21 or 15; 20 or 17) between the elastomer spring element (5 or 16) and the housing (bearing parts 3 or 9) or the tension rod (6, 22) of the drawbar coupling. Alternatively, the pressure sensor (10) can be arranged on the elastomer spring element (5 or 16). 
<??>The preferred area of application of the invention is vehicular technology.
Patent JP-3865319-B2 (JP)
IPC: C12R1/92
Filed: 1996-06-06
Granted: 2007-01-10
Abstract: A method for killing tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with an essential herpes simplex virus gene which is driven by a tumor-specific or cell-specific promoter that specifically destroys tumor cells and is not neurovirulent. Also, a method for producing an animal model, by ablating a specific cell type in vivo, entails providing replication competent herpes simplex virus vectors to the animal. Such a vector, with an essential herpes simplex virus gene driven by a cell- or tissue-specific promoter, specifically destroys the target cell type. This method of viral-mediated gene therapy employs cell-specific viral replication, where viral replication and associated cytotoxicity are limited to a specific cell-type by the regulated expression of an essential immediate-early (IE) viral gene product.
Patent JP-3681388-B2 (JP)
IPC: C07D513/04
Filed: 1994-07-06
Granted: 2005-08-10
Abstract: PCT No. PCT/EP94/02287 Sec. 371 Date Dec. 13, 1995 Sec. 102(e) Date Dec. 13, 1995 PCT Filed Jul. 6, 1994 PCT Pub. No. WO95/02600 PCT Pub. Date Jan. 26, 1995The present invention is concerned with novel imidazoazepines of formula    <IMAGE>  (I)  the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -A-B- is a radical of formula -X-CH=CH- (a-1); -CH=CH-X- (a-2); or -CH=CH- CH=CH- (a-3); X represents O, S or NR1; R1 represents hydrogen or C1-6alkyl; +E,ovs -----+EE Y is a radical of formula =O (b-1); -OH (b-2); or =N-OH (b-3); and L represents hydrogen, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenylcarbonyl, C1-6alkyl or C1-6alkyl substituted with C1-4alkyloxycarbonyl, hydroxycarbonyl, aryl, aryloxy or a radical of formula    <IMAGE>  (c)  -D-Z- is -S-CH=CH-, -S-CH2-CH2-, -S-CH2-CH2-CH2-, -CH=CH-CH=CH- or -CH2-CH2-CH2-CH2-; and aryl is phenyl or phenyl substituted with halo, hydroxy or C1-4alkyloxy. Compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating allergic diseases.
Patent JP-2670696-B2 (JP)
IPC: G01N33/531
Filed: 1988-09-30
Granted: 1997-10-29
Abstract: A novel bidentate conjugate has two different chemical moieties, or bidentate members, attached through an adequate spacer moiety. Each bidentate member acts as a small molecule ligand and is capable of specifically binding to a different macromolecular substance. The bidentate members are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected so that both bidentate members can simultaneously bind to their respective specific binding partners. Where the specific binding partners are multivalent, large complexes can be formed. The formation of these complexes can be inhibited by the presence of an unconjugated monovalent bidentate member, such as free analyte from a test sample. The bidentate is of particular use in turbidimetric or nephelometric inhibition immunoassay procedures.
Patent JP-3157161-B2 (JP)
IPC: C09C1/28
Filed: 1992-10-02
Granted: 2001-04-16
Abstract: Paper coating pigments comprising mechanically delaminated kaolin particles. The pigments possess the opacification, smoothness and printability advantages of conventional delaminated kaolin pigments but have desirably low viscosity and gloss not characteristic of conventional delaminated kaolin pigments. Crude kaolins of specified physical characteristics for production of these pigments by controlled delamination.
Patent JP-3670293-B2 (JP)
IPC: A61M5/168
Filed: 1996-08-29
Granted: 2005-07-13
Abstract: A pumping segment of a fluid line alternately in fluid communication with the upstream and downstream portions of the fluid line connects a fluid supply to a fluid receiver. A pressure sensor located downstream of the segment monitors the pressure during the segment's communication with the upstream and downstream ends. The pressure difference is used to establish a pressure threshold against which the average pressure is compared to determine if an upstream occlusion exists. Should the average pressure fall within a cautionary zone, the pump is reversed to examine the pressure difference once again. Based on the pressure difference during the reversal, a pressure threshold line may be adjusted thereby adapting to fluid administration conditions.
Patent JP-3006774-B2 (JP)
IPC: C05G5/00
Filed: 1995-09-22
Granted: 2000-02-07
Abstract: The present invention describes a sulfur-coated urea slow release granular fertilizer having a uniform, durable polymeric coating over the sulfur-coating. The polymer coating is formed by the direct in situ co-polymerization of diethylene glycol-triethanolamine polyol and a diisocyanate on the surface of the sulfur-coated urea granule. The polymeric coating provides improved impact resistance of the composite coated granule.
Patent JP-3306593-B2 (JP)
IPC: A61C11/02
Filed: 1991-08-08
Granted: 2002-07-24
Abstract: Face bow for receiving and transferring a jaw model with the correct spatial orientation relative to the skull into a jaw joint articulator, comprising a transfer bracket (60) surrounding the face and a guide column (80) releasably fastened thereon and intended to carry an adjustable mouthpiece (86). The bracket (60) has an elongated centering depression on its upper and lower sides (1, 2), and the guide column (80) has an adjustment projection (85) which is adapted to be inserted in positively locking manner in the centering depression (82).
Patent JP-3547739-B2 (JP)
IPC: F16H3/64
Filed: 1991-08-22
Granted: 2004-07-28
Abstract: The crown wheel (2) of a planetary gear (5) is connected to the input shaft (7) while the planet carrier (4) is connected to the output shaft (12). The sun wheel (1) is locked by means of a free wheel (14) when the clutch (9) is released. The device then operates as a reduction gear. The sun wheel (1) rotates with the crown wheel (2) and the planet carrier (4) when the clutch (9) is engaged. The axial forces (FAP?, FAC?), sustained by the sun wheel (1) and the crown wheel (2) when in gear-reduction mode, and resulting from the helical tooth configuration, tend through the stop (17) to compress a spring (18) and release the clutch (9). When in direct drive and beyond a certain torque, the clutch (9) slips, thereby generating the above-mentioned axial forces which compress the spring and accelerate disengaging. The device operates as a reduction gear until the torque on the shaft (7) is reduced, thereby enabling the spring (18) to re-engage the clutch. For use on the input side of a gear box in order to automatically reduce speed ratios during acceleration, the gear box being itself preferably automatically controlled, especially under the effect of axial forces generated by other planetary gears.
Patent JP-3001984-B2 (JP)
IPC: B29L11/00
Filed: 1996-11-15
Granted: 2000-01-24
Abstract: This invention relates to a new and improved light-polarizing sheet comprising molecularly oriented polyvinyl alcohol containing an oriented block segments of polyvinylene and said polyvinyl alcohol. In particular, the polarizing sheet comprises a polyvinylalcohol/polyvinylene block copolymer material wherein the polyvinylene blocks thereof are formed by molecular dehydration of a sheet of polyvinylalcohol; said sheet of polyvinylalcohol/polyvinylene block copolymer material comprising a uniform distribution of light-polarizing molecules of polyvinylalcohol/polyvinylene block copolymer material varying in the length, n, of the conjugated repeating vinylene unit of the polyvinylene block of the copolymer throughout the range of from 2 to 24; the concentration of each of said polyvinylene blocks, as determined by the absorption of wavelengths ranging from 200 to 700 nm remaining relatively constant, the degree of orientation of said light-polarizing molecules, as measured by the spectral dichroic ratio, RD, of said blocks, increasing throughout said range with increasing length, n, of said polyvinylene blocks; said polyvinylene block concentration and said degree of orientation of said molecules imparting to said sheet a photopic dichroic ratio, RD, of at least approximately 45.
Patent JP-3834061-B2 (JP)
IPC: B65D47/20
Filed: 1997-01-07
Granted: 2006-10-18
Abstract: PCT No. PCT/FR97/00021 Sec. 371 Date Jul. 8, 1998 Sec. 102(e) Date Jul. 8, 1998 PCT Filed Jan. 7, 1997 PCT Pub. No. WO97/25253 PCT Pub. Date Jul. 17, 1997A nozzle for dispensing a liquid or semi-liquid substance (P) and designed to be mounted on a tank (R) suitable for being put under pressure. The nozzle is of the type comprising a thimble (1) and moving shutter (2) housed inside the thimble. The thimble (1) is provided with a coupling end (11) for coupling to the tank (R) and an ejection orifice (10). The shutter (21) is constituted by a rod (21) carrying a plug (20) at an outer end thereof. The plug (20) cooperates with the ejection orifice (10) to form a delivery valve. The rod (21) also carries a transverse wall (22) at an inner end thereof. The wall (22) leaves a passage for the substance (P) and cooperates with a resilient return means (3) for returning the moving shutter (2) towards a closed position in which the plug (20) is engaged in sealed manner in the ejection orifice (10). The nozzle further comprises an admission valve constituted by a deformable peripheral lip (23) around the rod (21) which subdivides the passage for the substance (P) in sealed manner into an upstream compartment and a downstream compartment.
Patent JP-4034351-B2 (JP)
IPC: C12Q1/6837
Filed: 1997-04-24
Granted: 2008-01-16
Abstract: A planar array of beads in a spatially non-random configuration, said array comprising a plurality of different particle types, wherein each of said particle types has a different ligand attached thereto for forming a complex with an analyte, and wherein said particle types are encoded with a chemical or physical characteristic that uniquely identifies the ligand of said particle type, and wherein said array of particle is configured such that when said array of particles is contacted with liquid comprising an analyte, the particles of said array in a contiguous liquid phase.
Patent JP-3955103-B2 (JP)
IPC: A61K31/70
Filed: 1998-03-03
Granted: 2007-08-08
Abstract: The present invention relates to a protection-effective amount of UV-damaged RNA fragments, in combination with a cosmetically or pharmaceutically acceptable carrier. The compositions are useful in the prevention of skin damage to UV radiation and in preventing photoaging.
Patent MD-3640-B2 (MD)
Title: Reactor de electroporatie pentru prelucrarea continua a produselor in bucati
Inventor: SCHULTHEISS CHRISTOPH
IPC: A23C3/07
Filed: 2002-08-27
Abstract: Inventia se refera la un reactor de electroporatie pentru prelucrarea continua a produselor in bucati, cum sunt produsele agricole sau de origine animala. Reactorul reprezinta un tambur (7) cu elemente de antrenare (5), dispuse pe suprafata lui exterioara, care se roteste intr-un lichid de prelucrare, preferential in apa, care se contine intr-o camera si antreneaza produsul ce se prelucreaza, care este introdus printr-o deschidere. La imersare, materialul de prelucrat sau materialul recoltat este mai intai degazat pana cand, fiind transportat in continuare, ajunge in zona de prelucrare propriu-zisa, unde este expus unor campuri electrice de inalta tensiune si de scurta durata in asa fel incat diferenta de potential necesara pentru poratie poate sa actioneze de-a lungul axei longitudinale a celulei. Fiind transportat in continuare, materialul de prelucrat este ridicat din reactor de catre un saber (14) si dirijat la un jgheab de evacuare (15).
Patent AU-2000255121-B2 (AU)
Title: Electrodynamic machine
Inventor: BARREIRO MANUEL VIEIRA
IPC: H02K16/00
Filed: 2000-06-29
Granted: 2006-04-27
Abstract: An electrodynamic machine (10) comprising a first rotor (13) and a second rotor (15). The first and second rotors (13, 15) are adapted to rotate relative to each other, preferably in opposite directions. The electrodynamic machine (10) may operate as an electric generator or as an electric motor.
Patent AU-2001250231-B2 (AU)
Title: Installation for treating sheets of printed paper
Inventor: SCHAEDE JOHANNES GEORG
IPC: B41F33/14
Filed: 2001-04-30
Granted: 2004-10-28
Abstract: The plant, comprising feed (1), transfer (3) and stacking (21, 22, 23) sections, incorporates an optoelectronic print quality control section with a camera (5) inside a perforated transfer drum (4), a section (12, 13, 14) for printing serial numbers and/or supplementary data, and a system (19) for marking those sheets which are found to be sub-standard by the quality control section. The sheets then go into three stacks for those of acceptable quality, those which are faulty, and those that need to be re-checked.