baber/WOPTO huggingface dataset:
Patent CA-3061276-A1 (CA)
Title: Poly-lysine derivative stabilize solid-based compositions comprising one or more salts
Inventor: KALT MARKUS
IPC: C07C233/36
Filed: 2018-05-11
Abstract: A polymeric stabilizing agent selected from poly-lysine derivatives obtained by the process comprising the steps of: I. heating an aqueous lysine solution to boiling II. increasing temperature of the aqueous lysine solution to a reaction temperature in the range of about 105°C to about 180°C Ill. keep the reaction temperature in the range of about 105°C to about 180°C until i. melt viscosity of the reaction mixture in the range of about 350 mPa*s to about 6,500 mPa*s when measured at 160°C and ii. an amine number in the range of about 100 mg KOH/g to about 500 mg KOH/g is achieved IV. optionally, the vacuum applied is released V. add alkyl-carboxylic acid or alkenyl-carboxylic acid in amounts of 2.5 mol% to 10 mol%, relative to the theoretical amount of poly-lysine comprised in the reaction mixture VI. increase or keep the reaction temperature in the range of about 105°C to about 180°C until number of free alkyl-carboxylic acid or alkenyl-carboxylic acid is = 9% by weight, relative to the total weight of the reaction mixture, wherein vacuum is applied either in step (a), (b) and/or (c) and water is removed continuously during the whole process.
Patent CA-3062119-A1 (CA)
Inventor: ZHANG QIN
IPC: G06F16/901
Filed: 2017-12-29
Abstract: Provided in the present application is a method for setting a sample weight.  The method comprises: acquiring popularity index values of training samples (100);  determining, for the samples, and according to the respective popularity index values, individual popularity index weights corresponding to the popularity index (110); and determining a sample weight for the sample according to the individual popularity index weights corresponding to all popularity indexes (120).
Patent CA-3062858-A1 (CA)
Title: Individual and cohort pharmacological phenotype prediction platform
Inventor: ATHEY BRIAN D
IPC: G16B30/00
Filed: 2018-05-11
Abstract: For patients who exhibit or may exhibit primary or comorbid disease, pharmacological phenotypes may be predicted through the collection of panomic, physiomic, environmental, sociomic, demographic, and outcome phenotype data over a period of time. A machine learning engine may generate a statistical model based on training data from training patients to predict pharmacological phenotypes, including drug response and dosing, drug adverse events, disease and comorbid disease risk, drug-gene, drug-drug, and polypharmacy interactions. Then the model may be applied to data for new patients to predict their pharmacological phenotypes, and enable decision making in clinical and research contexts, including drug selection and dosage, changes in drug regimens, polypharmacy optimization, monitoring, etc., to benefit from additional predictive power, resulting in adverse event and substance abuse avoidance, improved drug response, better patient outcomes, lower treatment costs, public health benefits, and increases in the effectiveness of research in pharmacology and other biomedical fields.
Patent CA-3064522-A1 (CA)
Title: Compositions biopharmaceutiques et procedes associes
Inventor: GRANT STEVEN
IPC: C07K16/24
Filed: 2018-05-24
Abstract: La présente invention concerne des compositions de liaison à l'antigène, notamment des anticorps, destinées au traitement de maladies induites par l'interleukine 5 (IL-5), et des procédés associés. Selon l'invention, l'IL-5 est une protéine sécrétée. L'IL-5 joue un rôle dans un certain nombre de maladies différentes, telles que l'asthme, l'asthme léger, l'asthme modéré, l'asthme sévère, l'asthme éosinophile léger, l'asthme éosinophile modéré, l'asthme éosinophile sévère, l'asthme éosinophile non contrôlé, l'asthme éosinophile, l'asthme sous-éosinophile, la broncho-pneumopathie chronique obstructive, la granulomatose éosinophile avec la polyangéite, le syndrome hyperéosinophile, la polypose nasale, la pemphigoïde bulleuse, l'sophagite à éosinophiles, la dermatite atopique, la dermatite atopique modérée et la dermatite atopique sévère. Les compositions de l'invention sont appropriées pour traiter ces maladies graves à médiation par IL-5.
Patent CA-3065843-A1 (CA)
Inventor: YANG NING
IPC: H04W76/19
Filed: 2017-07-21
Abstract: L'invention concerne un procédé de récupération de connexions multiples dans un état non activé, et un dispositif associé. Le procédé consiste : à recevoir une requête de récupération de connexion envoyée par un terminal, et à acquérir la configuration d'au moins un nud et/ou un rapport de mesure d'au moins un nud; en fonction de la configuration d'au moins un nud et/ou du rapport de mesure d'au moins un nud, à ajouter une partie ou la totalité des nuds parmi le ou les nuds en tant que nuds auxiliaires du terminal. Ainsi, après qu'un terminal entre dans un état non activé, un état de connexion peut être récupéré dès que possible lorsque cela est nécessaire, garantissant ainsi que le terminal peut récupérer rapidement des services associés.
Patent CA-3065900-A1 (CA)
Title: Aminoglycoside derivatives and uses thereof in treating genetic disorders
Inventor: BAASOV TIMOR
IPC: C07H15/222
Filed: 2018-06-05
Abstract: Novel aminoglycosides, represented by Formulae (e.g., a compound of Formula A, B, I, I*, III or III*, including compounds represented by Formula Ia, I**, I*a, I*b, IIIa, III**, III*a and, III*b), as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
Patent CA-3066162-A1 (CA)
Inventor: BEZLEPKIN VLADIMIR VIKTOROVICH
IPC: G21C15/18
Filed: 2018-12-28
Abstract: The method and system for bringing a nuclear power plant to a safe state after extreme effect are intended to reduce the temperature of the coolant after extreme effect, in particular, when the aircraft falls, below the boiling point. The system comprises inlet and outlet pipelines, a steam generator, a storage tank and a heat exchanger, a separation tank located above the steam generator and connected by two pipelines to a storage tank, a pump, a control unit, the heat exchanger is installed in the outlet pipeline, the first water valve is installed in the inlet pipeline, and the separation tank is connected with a storage tank by a pipeline with a second water valve installed in it and a pipeline with a first air valve installed in it. The method of bringing a nuclear power plant into a safe state after extreme effect involves filling the system with coolant, feeding the coolant from the steam generator through the inlet pipeline and the storage tank to the heat exchanger, and then feeding the coolant through the outlet pipeline back to the steam generator, wherein the pump is turned on for feeding the coolant and subsequent operation of the system, the first air valve is used to maintain pressure in the system, ensuring the absence of boiling of the coolant, and prior to feeding the coolant into the storage tank it is first fed to the separation tank located above the steam generator.
Patent CA-3066587-A1 (CA)
Title: Pivotal handle for folding a ramp of a vehicle
Inventor: NUNN ROBERT
IPC: B65G69/28
Filed: 2020-01-06
Abstract: . . P9320CA00 ABSTRACT A pivotal handle assembly is attached to a folding ramp to move the ramp from a raised transport position inside a vehicle to a lower, use position extending between the vehicle and the ground. The handle assembly extends upwardly in both the transport and the use positions, and allows an operator to fold and unfold the ramp assembly without bending down so as to minimize back strain. 9 CA 3066587 2020-01-06
Patent CA-3066904-A1 (CA)
Title: Bromhexine for the treatment of pain
Inventor: KERN KAI-UWE
IPC: A61P29/02
Filed: 2018-06-13
Abstract: The invention relates to bromhexine or a salt thereof for treating acute or chronic pain in a patient. In particular, the invention relates to bromhexine or a salt thereof for use in treating nociceptive pain, neuropathic pain and or dysfunctional pain. The invention further relates to a topical pharmaceutical composition comprising bromhexine or a salt thereof and to a composition or a topical pharmaceutical composition comprising bromhexine or a salt thereof for treating acute or chronic pain.
Patent CA-3069173-A1 (CA)
Inventor: JONES FRANK
IPC: G06V30/224
Filed: 2017-01-12
Abstract: Near-to-eye displays support a range of applications from helping users with low vision through augmenting a real world view to displaying virtual environments. The images displayed may contain text to be read by the user. It would be beneficial to provide users with text enhancements to improve its readability and legibility, as measured through improved reading speed and / or comprehension. Such enhancements can provide benefits to both visually impaired and non-visually impaired users where legibility may be reduced by external factors as well as by visual dysfunction(s) of the user. Methodologies and system enhancements that augment text to be viewed by an individual, whatever the source of the image, are provided in order to aid the individual in poor viewing conditions and / or to overcome physiological or psychological visual defects affecting the individual or to simply improve the quality of the reading experience for the user.
Patent CA-3071852-A1 (CA)
Title: Method of conjugation of cys-mabs
Inventor: ACHMATOWICZ MICHAL
IPC: A61K47/68
Filed: 2018-08-03
Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
Patent CA-3072098-A1 (CA)
Title: Stimulator systems and methods for selectively recruiting fascicles in hypoglossal nerve trunk
Inventor: NG Boon Khai
IPC: A61N1/05
Filed: 2018-08-30
Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
Patent CA-3074153-A1 (CA)
Inventor: POULIN MAURICE
IPC: G06Q10/08
Filed: 2018-08-14
Abstract: A system for managing a list of products in an inventory includes a plurality of addressable LEDs, each for positioning adjacent a product storing position that includes an identification code; at least one code reader; and at least one controller coupled to both the plurality of addressable LEDs and the at least one code reader for i) receiving from the code reader a command indicative of the list of products; and ii) as a result of the command, controlling the addressable LEDs so as to energize LEDs therefrom corresponding to the list of products. A method for managing the list of products further includes verifying an identity of each product from the list by reading and comparing the identification code thereof to the identification code associated to the corresponding addressable LED.
Patent CA-3074249-A1 (CA)
Inventor: FURRER ESTHER MARIA
IPC: C07K16/24
Filed: 2018-09-11
Abstract: The present invention relates to antibodies which bind to TNF.alpha. and exhibit modified FcRn- binding. The antibodies of the invention have good effector functions and/or pharmacokinetic properties.
Patent CA-3074346-A1 (CA)
Title: Classification method and apparatus
Inventor: BALTHASAR DIRK
IPC: B07C5/342
Filed: 2018-09-03
Abstract: There is provided a method for object classification, the method comprising the steps of: guiding (S1) a continuous stream of objects (4) from a transport mechanism (2) directly into an unsupported path (6), along which said object stream (6) is fed through a detection region (12); illuminating (S2) said detection region (12) with a radiation band in a first direction (10); optically scanning (S3) said detection region (12) to detect electromagnetic radiation reflected by the at least one object in the detection region (12) by viewing said detection region along a second direction (16), wherein the first direction (10) and the second direction (16) have a cross-section in the detection region (12) and forms an angle relative each other within the range of 10° - 80°; analyzing (S4) the information from the optical scanning; and classifying (S5) objects from the object stream in at least two different directions based on the analysis of the transparency information from the optical scanning;  wherein the step of analyzing the information from the optical scanning comprises analyzing the objects based on the intensity, spread and texture of the detected radiation from the optical scanning.
Patent CA-3074428-A1 (CA)
Inventor: RAVICHANDRAN RANJITHKUMAR
IPC: A61K8/65
Filed: 2018-08-24
Abstract: The present invention relates to a polypeptide having a base amino acid sequence and wherein at least two amino acid residue side chains are substituted with functional Michael acceptor groups.  The invention further relates to cosmetic compositions comprising said polypeptide, a method for repairing damaged hair using the polypeptide or composition, and to the use of the polypeptide or composition in such methods.
Patent CA-3075412-A1 (CA)
Title: Process and apparatus for producing mycelium biomaterial
Inventor: MUELLER PETER JAMES
IPC: A61K36/8962
Filed: 2019-05-22
Abstract: The process for producing mycelium biomaterial provides fresh oxygen to the growing mycelium biomaterial while removing waste heat and waste carbon dioxide by forced aeration through large volumes of material. In a first phase of fungal expansion, humidified air at a programmed temperature is passed upwardly and through a fungal inoculated substrate of discrete particles to allow the fungal inoculum to expand and dominate the substrate. Nutrient is added to the inoculated mixture and a second phase of fungal expansion is performed wherein humidified air at a programmed temperature is passed upwardly and through the nutrient enriched fungal inoculated substrate to allow the fungal inoculum to bond the discrete particles into a self-supporting biocomposite. The process and apparatus of the invention allows for the processing of grown materials bound by mycelium at depths of greater than 6" and particularly in the range of from 24" to 28".
Patent CA-3079486-A1 (CA)
Title: Mutant of hemagglutinin protein of h3n2 subtype influenza virus and use thereof
Inventor: CHEN YIXIN
IPC: C12N15/09
Filed: 2018-10-10
Abstract: Provided are a mutant of an H3N2 subtype influenza virus hemagglutinin protein, a preparation method therefor, and a method of using the mutant to prevent and/or treat infections of an influenza virus and/or diseases (such as influenza) caused by the infections. Further provided is a pharmaceutical composition containing the mutant, such as a vaccine.
Patent CA-3081035-A1 (CA)
Inventor: FAVRESSE PHILIPPE
IPC: C08J3/20
Filed: 2020-05-21
Abstract: Process for producing a reaction product containing a non-cyclic alkoxy-functional polysiloxane by means of heating a reaction system comprising: (A) a cyclic polyorganosiloxane of the formula [(R12SiO) 1 where the subscript n is an integer /2/2,n , of at least 4 and each R1 is an alkyl group or aryl group; (B) a silane of the formula R2(4-m)Si(OR3)m, where the subscript m is an integer from 1 to 4, each R2 independently is an alkyl group or aryl group, a hydrocarbyl group or a halogenated hydrocarbyl group and each R3 independently is an alkyl group; and (C) a catalyst system comprising a metal trifluoromethanesulfonate of the formula [M][CF3S03]-, where M is a metal atom selected from sodium (Na) and potassium (K), and a Bronsted acid, wherein Bronsted acids having a pKa 3.0, preferably having a pKa 2.0, particularly preferably having a pKa - 0.0 are used.
Patent CA-3082600-A1 (CA)
Title: System and method for switching railcars using a static rail-track configuration
Inventor: SINGHAL ROHIT
IPC: B61F7/00
Filed: 2018-11-19
Abstract: The various embodiments herein provide an onboard track switching mechanism for a railroad vehicle to switch from one track to another. Currently available onboard railroad vehicle switching mechanisms employ complicated coordination between one or more switching wheels and complex control systems. Accordingly, system and method For enabling a railroad vehicle to switch tracks is disclosed. The system comprises a a running track that supports an automotive a switching track comprising a set of static components and a switching mechanism installed- on the automotive, the switching mechanism configured for controlling the movement of one or more switching wheels such that when activated, the switching mechanism is configured to facilitate engagement of the: one or more switching wheels with the switching track for carrying out a track changing operation for the automotive.
Patent CA-3083381-A1 (CA)
Title: Piercing machine, and method for producing seamless metal pipe using the same
Inventor: DAIMON YASUHIKO
IPC: B21B45/02
Filed: 2018-11-28
Abstract: Provided is a piercing machine capable of suppressing the temperature difference between a front end section and a rear end section of a hollow element tube following piercing/rolling or stretching/rolling. A piercing machine (10) is provided with: a plurality of inclined rolls (1), a plug (2), a mandrel bar (3), and an outer surface cooling mechanism (400). The outer surface cooling mechanism (400) is disposed behind the plug (2) and around the mandrel bar (3), and cools a hollow element tube (50) within a cooling region (32) by spraying a cooling fluid (CF) onto an upper section, a lower section, a left-side section, and a right-side section of the outer surface of the hollow element tube (50) as viewed in the advancing direction of the hollow element tube (50) advancing within the cooling region (32), which is disposed behind the plug (2) and has a certain length in the axial direction of the mandrel bar (3).
Patent CA-3083399-A1 (CA)
Title: Dispositif de commande d'une soudeuse par resistance
Inventor: OMORI NOBURO
IPC: B23K11/24
Filed: 2019-08-08
Abstract: Un contrôleur de soudage par résistance pour contrôler l'opération d'une soudeuse par résistance en fonction d'un courant de soudage et d'un taux d'utilisation, le contrôleur comprenant une unité de contrôle contrôlant un courant de soudage circulant dans un inverseur, une unité de détection de courant détectant le courant de soudage circulant dans l'inverseur, une unité de calcul de taux d'utilisation calculant, entre autres, un taux d'utilisation de l'inverseur au moyen d'un temps d'énergie et un intervalle de temps de point mesuré, une unité de stockage stockant une courbe de courant équivalent indiquant une relation entre une valeur de courant de soudage et le taux d'utilisation de l'inverseur lorsque celui-ci fonctionne à une puissance nominale et une unité de détermination déterminant si la relation entre la valeur de courant du courant de soudage détecté et le taux d'utilisation calculé de l'inverseur dépasse la puissance nominale de l'inverseur en fonction de la courbe de courant équivalent. Si la puissance nominale n'est pas dépassée, l'opération de l'unité de contrôle se poursuit et si elle est dépassée, l'opération de l'unité de contrôle est arrêtée.
Patent CA-3083532-A1 (CA)
Inventor: YAN JIAN
IPC: C12N15/12
Filed: 2018-12-13
Abstract: La présente invention concerne des molécules d'acide nucléique comprenant une ou plusieurs séquence(s) d'acide nucléique codant pour un antigène PRAME consensus muté. La présente invention concerne des vecteurs, des compositions et des vaccins comprenant une ou plusieurs séquence(s) d'acide nucléique codant pour un antigène PRAME consensus muté. La présente invention concerne en outre des procédés de traitement d'un sujet présentant une tumeur exprimant l'antigène PRAME et des procédés de prévention d'une tumeur exprimant l'antigène PRAME. La présente invention concerne en outre un antigène PRAME consensus muté.
Patent CA-3085508-A1 (CA)
Title: Probiotics for cognitive and mental health
Inventor: STENMAN LOTTA
IPC: A61P1/00
Filed: 2018-12-18
Abstract: The invention relates to bacteria of the species Lactobacillus paracasei and/or compositions comprising Lactobacillus paracasei for use in preventing and/or treating a mental illness, a symptom affecting mental health and/or a condition associated with chronic stress, in a mammal. The invention further relates to methods and uses of said bacteria of the species Lactobacillus paracasei and/or compositions. The invention can be applied in restoring, maintaining, and/or promoting mental (including cognitive) health and has potential applications, inter alia, in the area of dietary and food supplements, medicaments and pharmaceuticals.
Patent CA-3085534-A1 (CA)
Inventor: POTTIER AGNES
IPC: A61K33/242
Filed: 2018-12-18
Abstract: The present invention relates to the medical field, in particular to the enhancement of brain performances and for the treatment of pathological stress. More specifically the present invention relates to a nanoparticle or nanoparticles' aggregate for use in enhancing brain performances or in prevention or treatment of pathological stress in a subject without exposure of the nanoparticle or nanoparticles' aggregate to an electric field, and preferably without exposure thereof to any other external activation source, wherein the nanoparticle's or nanoparticles' aggregate's material is selected from a conductor material, a semiconductor material, an insulator material with a dielectric constant ?ijk equal to or above (200), and an insulator material with a dielectric constant ?ijk equal to or below (100). It further relates to compositions and kits comprising such nanoparticles and/or nanoparticles' aggregates as well as to uses thereof without exposure thereof to an electric field, and preferably without exposure thereof to any other external activation source such as a light source, a magnetic field, or an ultrasound source.
Patent CA-3086440-A1 (CA)
Inventor: FEDER MARCIN
IPC: A61K31/407
Filed: 2019-01-09
Abstract: The invention relates to 1,2,3',5'- tetrahydro- 2?- spiropndole- 3,1 '- pyrrolo[3,4- c]pyrrole]- 2,3'- dione compounds represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, blinding disease and viral infections.
Patent CA-3087939-A1 (CA)
Inventor: KOENEN CHARLES ANTHONY
IPC: C04B14/00
Filed: 2020-07-24
Abstract: A landscaping block, patio block, having a gloss finished pebble stone surface and a styrofoam material backing to form a block that can be used in landscaping, patio block systems utilizing a plurality of assorted sizes. The blocks having the gloss finished pebble surface can be used in the construction of patios, pathways to create a geometrical design or pattern or a repeating geometric design or pattern in a visually exposed surface patio , walkway.