baber/WOPTO huggingface dataset:
Patent JP-4020425-B2 (JP)
IPC: C07C233/00
Filed: 1995-01-09
Granted: 2007-12-12
Abstract: Prepn. of enantiomerically pure cyclopentane- or cyclopentene- beta -aminoacids of formula (I) comprises:(a) converting a meso-cyclopentane- or cyclopentene dicarboxylic anhydride of formula (II) into an enantiomerically pure monoester of formula (IVa) via enantiomerically pure salt of formula (IV), by asymmetric alcoholysis with an alcohol of formula (III) in a solvent in presence of an equimolar amt. of a chiral amine base in pure enantiomer form;(b) activating the free carboxy function then reacting with liq. ammonia to give the enantiomerically pure amide of formula (V);(c) cleaving the ester residue R<15> in an inert solvent in presence of a nucleophilic auxiliary, by enzymatic methods or in presence of a palladium catalyst to give the acid or salt of formula (VI);(d) carrying out Hoffmann rearrangement with alkali(ne earth) metal hypochlorite in aq. alkali(ne earth) metal hydroxide soln.;(e) blocking the free amino gp. in soln. using a conventional amino-protecting gp., isolating the protected cpds. and cleaving the protecting gp. to give the pure enantiomer of (I). A,L = H;D, E = H, halo, OH or 1-8C alkyl,etc.; or D+E = =CR<6>R<7>, =N-OH, =O or =S; or A+D or E+L = additional bond;R<6>, R<7> = H, halo, 1-8C alkyl, 1-8C alkoxy,etc.; R<2> = H, amino-protecting gp., 1-8C alkyl (opt. substd. by 1 or 2 of OH, CHO up to 6C acyl, phenyl and benzoyl, where phenyl and benzoyl are themselves opt. substd. by 1 or 2 of halo, NO2, CN and 1-6C alkyl),etc.;R<3> =H or 1-8C alkyl (opt. substd. by phenyl); or R<2>+R<3> = =CHR<14>;R<14> = H or 1-8C alkyl (opt. substd. by halo, OH,etc.;T = O, S or NH; R<1> = H, 1-8C alkyl (opt. substd. by 1-3 of OH, halo,etc.), phenyl (opt. substd. by 1-3 of OH, halo, NO2,etc.);or if T = e.g. NH, R<15> = 2-5C alkyl or 2-5C alkenyl (opt. substd. by CN, SiMe3, Ph or CCl3);V = chiral amine base;X = H, alkali metal or alkaline earth metal. Enantiomerically pure cpds. (IV), (IVa) and (V) are new.
Patent JP-4358907-B2 (JP)
IPC: C08F290/06
Filed: 1995-12-18
Granted: 2009-11-04
Abstract: An esterified macromonomer within the scope of general formula (I), wherein Z is an organic moiety, R1 is hydrogen or a substituted or unsubstituted alkyl having from 1 to 12 carbon atoms, oxyalkyl having from 1 to 12 carbon atoms, alkenyl having from 2 to 12 carbon atoms, cycloalkyl having from 5 to 12 carbon atoms, aryl having from 6 to 12 carbon atoms or aralkyl having from 7 to 12 carbon atoms, each E independently is a hydroxil group, an organic  ester moiety or an inorganic ester containing moiety and at least one E is an ester containing moiety, n and m each independently is an integer from 2 to 12. The esterified macromonomer is obtainable by esterification of at least a portion of the -OH groups of a macromonomer having at least one terminal double bond with at least one derivative of an inorganic or organic acid which introduces pendant groups exhibiting at least one acid moiety selected from the group consisting of -COOH, -PO3H2, -SO3H, -BO2H or salts thereof. The number of the acid moieties is chosen such that a polymer obtained by polymerizing those monomers has an adhesive strength to dentine of at least 2 MPa.
Patent JP-4505058-B2 (JP)
IPC: H04S5/02
Filed: 1997-10-31
Granted: 2010-07-14
Abstract: An audio enhancement system and method for use receives a group of multi-channel audio signals and provides a simulated surround sound environment through playback of only two output signals. The multi-channel audio signals comprise a pair of front signals intended for playback from a forward sound stage and a pair of rear signals intended for playback from a rear sound stage. The front and rear signals are modified in pairs by separating an ambient component of each pair of signals from a direct component and processing at least some of the components with a head-related transfer function. Processing of the individual audio signal components is determined by an intended playback position of the corresponding original audio signals. The individual audio signal components are then selectively combined with the original audio signals to form two enhanced output signals for generating a surround sound experience upon playback.
Patent JP-3808501-B2 (JP)
IPC: C12N15/70
Filed: 1995-03-29
Granted: 2006-08-16
Abstract: A plasmid for expression of Moloney Murine Leukemia Virus-derived reverse transcriptase in E. coli cells deficient in the expression of indigenous RNAse activity, a method for purification of the recombinant enzyme, and a composition comprising a cloned and purified reverse transcriptase optimized for use in cDNA and nucleic acid amplification procedures. <IMAGE>
Patent JP-3303976-B2 (JP)
IPC: A61F2/30
Filed: 1996-02-27
Granted: 2002-07-22
Abstract: An spinal fixation device for stabilizing vertebrae. A hollow screw is inserted into a hole saw recess in each adjoining vertebrae. A channel is cut into the vertebrae into which a joining rod is inserted such that no part of the device protrudes above the bone. A locking cap is used to secure the rod to the screws.
Patent JP-3004728-B2 (JP)
IPC: C07D405/14
Filed: 1995-03-20
Granted: 2000-01-31
Abstract: PCT No. PCT/IB95/00189 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Mar. 20, 1995 PCT Pub. No. WO95/29909 PCT Pub. Date Nov. 9, 1995This invention relates to compounds of formula (IA), (IB), (IC) or (ID), wherein m, X, Z, R2, R3, R4, R5, R6, R14 and the dotted lines are as defined below, their pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of using them to treat Alzheimer's disease, age-associated memory impairment, Parkinson's disease and other central nervous system disorders. The claimed compounds have the ability to enhance the release of neurotransmitters such as acetylcholine, dopamine and serotonin.    <IMAGE>  (IA)
Patent MD-2711-B2 (MD)
Inventor: BOSTAN ION
IPC: F16H1/00
Filed: 2001-11-14
Abstract: Inventia se refera la constructia de masini, si anume la transmisiile planetare precesionale.Transmisia, conform primei variante, include un corp cu capac, in care sunt amplasate un arbore conducator si, cinematic legat cu el, executand o miscare de precesie, un satelit cu un dispozitiv ce previne rotirea lui in jurul axei sale, precum si o roata dintata condusa, care interactioneaza cu el. Transmisia este dotata suplimentar cu o bucsa de reazem, amplasata din partea satelitului si fixata pe arborele conducator. Intre suprafata interioara frontala a capacului corpului si suprafata frontala a flansei bucsei de reazem adiacenta ei, de asemenea, intre suprafata frontala a flansei orientata spre satelit, care este executata oblica, si suprafata frontala a satelitului este amplasat cate un rulment axial. Intre dintii satelitului si rotii dintate conduse sunt amplasate liber role conice, numarul carora este egal cu numarul dintilor satelitului sau rotii dintate conduse. Mecanismul ce previne rotirea satelitului in jurul axei sale, include cel putin trei bile situate uniform pe circumferinta, fiecare fiind liber amplasata in locasul executat pe suprafata laterala a satelitului, fiind totodata amplasata in canelura longitudinala executata pe peretele interior al corpului. Transmisia, conform variantei a doua, se caracterizata prin aceea ca include suplimentar o roata dintata centrala, fixata din partea plasarii arborelui conducator opusa rotii dintate conduse, coaxial lui si interactioneaza cu satelitul, de asemenea, cuprinse de ele, doua bucse de reazem, una dintre care este fixata pe arborele conducator, iar a doua, legata rigid cu ea, este montata in butucul rotii dintate conduse cu posibilitatea rotirii fata de el. Suprafetele frontale ale flanselor bucselor de reazem, orientate una spre alta, sunt executate oblice si paralele. ŕ
Patent MD-2616-B2 (MD)
Inventor: GAVRILCHENKO IGOR
IPC: F24H1/08
Filed: 2003-01-11
Abstract: Inventia se refera la energeticaŹ si anume la cazane pentru uz individual utilizate la incalzirea locuintelor.Cazanul de incalzire contine un cadru dotat cu tevi amplasate coaxialŹ pentru aspiratia aerului din afara si pentru eliminarea produselor de ardereŹ o camera de ardere cu arzator si un corp cu sectiune dreptunghiularaŹ amplasat in mantaŹ deasupra camerei de ardereŹ dotat cu racorduri pentru alimentarea cu apa rece si debitarea apei incalziteŹ incluzand sectiile amplasate verticalŹ cavitatile caror sunt umplute cu apa. Noutatea consta in aceea ca una din sectiile corpului este executata cu sectiune in forma de UŹ in partea inferioara a carei este instalat un racord pentru alimentare cu apa receŹ iar alta sectie este executata in forma de LŹ partea verticala a carei este amplasata din partea proeminentelor sectiunii in forma de U si alaturata de ele. Partea verticala a sectiunii in forma de L si una din proeminentele sectiunii in forma de U sunt cuplate printr-o teavaŹ partea orizontala a sectiunii in forma de L este amplasata cu joc deasupra sectiunii in forma de U si comunica cu ea printr-o teavaŹ in peretele partii orizontale este instalat racordul pentru debitarea apei incalzite. Intre sectii este format un canal vertical deschis in partea de sus si de josŹ sub golul inferior al carui este amplasat un arzatorŹ iar in golul superior a canalului vertical deschis sunt montate in forma de labirintŹ una deasupra alteiŹ doua despartituriŹ partial acoperind-ul. Fiecare sectiune a corpului contine doua elementeŹ fiecare fiind realizat dintr-o bucata de tabla integra. Despartitura superioara este fixata pe peretele sectiunii in forma de UŹ iar cea inferioara - pe peretele sectiunii in forma de L. ŕ
Patent EA-010649-B2 (EA)
Title: Curing and prophylactic agent applied during the use of alcohol
Inventor: ZENOVITCH SERGEI MIKHAILOVICH
IPC: A61K31/185
Filed: 2004-07-01
Abstract: The invention relates to medicine and is directed at developing means and methods for narcological practice and for preventive measures in order to reduce the risk of falling sick with such menacing modern disease like alcohol dependence. The invention provides using already known chemical compounds, i.e. vicinal dithioglycols. It is proposed to use thereof according to a new administration, namely for developing medical agents exhibiting properties for preventing contraction or development or reducing the speed of pathological processes forming a base for alcohol disease, in particular withdrawal syndromes. The inventive substances reduce or block pharmacological effects resulting from ethanol injection, thereby directly influencing pathogenic mechanisms of the disease development of alcohol dependence. It is stated that said agents are particularly efficient when they are perorally administered. Said invention is accompanied by experimental material which proves the large perspective of the inventive agents and of a prophylactic method which provides for the use thereof before and after consuming alcohol-containing beverages. The use of the invention makes it possible to reduce the degree of falling sick with alcoholism and to reduce the toxic action of alcohols during the household use thereof.
Patent ES-2171128-B2 (ES)
Title: Equipo de inseminacion artificial post cervical en ganado porcino.
Inventor: GIL PASCUAL JAVIER
IPC: A61D19/02
Filed: 2000-09-29
Granted: 2003-11-01
Abstract: Equipo para inseminación artificial post cervical en ganado porcino. Provisto de la clásica cánula (1), rematada por su extremidad anterior en una punta (4), de fijación al cuello del útero, de la que es prolongación una canulita (3) de menor diámetro, el equipo presenta dicha canulita (3) cerrada mediante un tapón (6), alargada y de revolución, de frente redondeado, con una depresión perimetral y curvo-cóncava (7) a nivel medio, donde se establecen los orificios (8) de salida para el semen, concretamente dos orificios en oposición diametral, cuyo posicionamiento, para que queden debidamente enfrentados a los cuernos uterinos de la cerda tras la introducción del catéter, queda definido por una señal (11 existente en la canulita (3) o en su conector (12), lo que optimiza las condiciones de inseminación permitiendo un menor consumo de semen. Además la extremidad posterior (10) del tapón (6) presenta un diámetro superior al de la canulita (3), para proteger la arista del extremo libre de estaúltima evitando danos en la mucosa de la cerda. Para facilitar el proceso de aplicación y evitar la contaminación de la parte distal de la canulita ésta se presentará dividida en dos porciones acoplables, estando la más distal introducida y por lo tanto protegida dentro del catéter convencional.
Patent ES-2192445-B2 (ES)
Title: Sistema para la realizacion de ensayos de carga concentrada sobre membranas.
Inventor: BALLESTER MUNOZ FRANCISCO
IPC: G01N3/10
Filed: 2001-05-04
Granted: 2004-05-01
Abstract: El sistema para la realización de ensayos de carga concentrada sobre membranas consta de un marco (2) en el que se sujeta la muestra de la membrana (1) en todo su perímetro. Este marco se coloca sobre unos apoyos rígidos (5). Por el centro de la muestra se hace pasar una barra de acero con rosca (4) y se ancla en el suelo (8). Sobre la membrana se coloca una placa (6) para la aplicación de la carga sobre la membrana. Esta placa tiene un taladro para que pase la barra anclada. La barra se hace pasar por el interior de un cilindro hidráulico (7) y se pone un tope (9) en la parte superior. El cilindro hidráulico (7) aplica la fuerza sobre la placa.
Patent ES-2204302-B2 (ES)
Inventor: ARMENGOL ASPARO MONTSERRAT
IPC: C07D491/04
Filed: 2002-08-07
Granted: 2005-03-01
Abstract: In particular, this invention relates to the synthesis intermediates (IV), (V), (VI) and (VIII) useful for preparing zolmitriptanzohnitriptan or a pharmaceutically acceptable salt thereof, which includes a) Ppreparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give hydrazine (III); b) In situ Reaction of the hydrazine hydrochloride (III) with alpha-keto-delta-valerolactone, to give the hydrazone (IV); c) Fischer indole synthesis of the hydrazone (IV), to give the pyranoindolone of formula (V); d) Ttransesterification of the pyranoindolone (V) to provide the compound (VI), in which R means a straight or branched C1-C4 alkyl; e) Conversion of the hydroxyl group of the compound (VI) into dimethylamino to give the indolecarboxylate (VII), in which R means a straight or branched C1-C4 alkyl; f) Ssaponification of the 2-carboalkoxy group of the compound (VII), to provide indolecarboxylic acid (VIII); g) Ddecarboxylation of the indolecarboxylic acid (VIII), to provide zolmitriptan and, eventually, to provide a pharmaceutically acceptable salt thereof.
Patent ES-2246743-B2 (ES)
Title: Aislador de seccion para catenaria rigida.
Inventor: MELIS MAYNAR MANUEL
IPC: B60M1/18
Filed: 2005-10-06
Granted: 2007-08-16
Abstract: Aislador de sección para catenaria rígida que presenta una doble funcionalidad, pues puede ejercer las funciones tanto de aislador de sección convencional como de sección neutra, configurado de manera que mantiene una continuidad mecánica tal que permite el paso del pantógrafo de manera suave, minimizando la necesidad de regulación y de mantenimiento. El aislador comprende básicamente un par de segmentos de carril conductor (2) entre los que se dispone un único patín central (1) dispuesto de forma oblicua respecto de la dirección de la catenaria, un par de hilos apagachispas (9) en los que se produce la rotura del campo eléctrico y una serie de pletinas (8) dispuestas en dicho patín central (1) que, junto a un cable de puenteo que se extiende desde ellas hasta el segmento de carril conductor (2), permiten puentear el hilo conductor del aislador (3) cuando se desea mantener la alimentación eléctrica al pantógrafo.
Patent ES-2323843-B2 (ES)
Title: Sistema de telemetria empleando comunicacion mediante campo magnetico para diagnostico y deteccion de episodios bruxistas.
Inventor: GONZALEZ BRIS CARLOS A
IPC: A61C19/04
Filed: 2009-03-31
Granted: 2010-02-15
Abstract: Sistema de telemetría empleando comunicación
mediante campo magnético para  diagnóstico y detección de episodios
bruxistas. 
     La presente invención consiste en un sistema de
telemetría que, mediante  comunicación inalámbrica empleando campo
magnético, permite el registro  permanente en tiempo real del
apretamiento/rechinamiento dental, conocido  como
"bruxismo". 
     Está basada en el empleo de un elemento sensor
pasivo/transceptor, cuyas  mínimas dimensiones permiten su
integración en una férula que se coloca  en la cavidad bucal, en
combinación con un elemento excitador/receptor,  situado en el
exterior de la cavidad bucal, manteniendo un consumo reducido  en la
electrónica intrabucal, que no necesita baterías ya que extrae la 
energía que necesita para operar del campo de excitación, lo que
permite  un funcionamiento perpetuo.
Patent AU-2001242139-B2 (AU)
Title: Faims apparatus and method using carrier gas of mixed composition
Inventor: PURVES RANDY
IPC: H01J49/42
Filed: 2001-03-14
Granted: 2005-12-01
Abstract: A method and an apparatus for selectively transmitting ions using a FAIMS analyzer is disclosed. An ion diverter is included within the FAIMS analyzer for affecting the trajectories of ions after separation to direct the ions in a known fashion. The ion diverter is optionally a gas flow source or an electrode for generating an electrical field to alter ion flow.
Patent AU-2001269478-B2 (AU)
Title: Hyaluronic acid oligosaccharide fractions and drugs containing the same
Inventor: ITO TOMOMI
IPC: A61K31/728
Filed: 2001-07-06
Granted: 2006-09-21
Abstract: Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety. <IMAGE>
Patent AU-2001294875-B2 (AU)
Title: Improved polyolefin-based synthetic fibers and method therefor
Inventor: CALDARA MAURO
IPC: D01F6/46
Filed: 2001-09-28
Granted: 2007-07-05
Abstract: The invention provides a method for making fibers and yarns having improved dyeability with reactive and disperse dyes, resistance to staining and improved mechanical properties and charecteristics. The method includes blending a polyolefin polymer and a fibril forming polymer to provide a mixture of polyolefin and fibril forming polymers. The mixture is conducted to a hot melt extruder to provide a substantially homogenous molten mixture of polyolefin and fibril forming polymers. The molten mixture is forced through a spinneret having a length to diameter (L/D) ratio ranging from about 3 to about 30 to provide a fiber having a polyolefin matrix and elongate, substantially discontinuous fibrils of the fibril forming polymer dispersed into the polyolefin matrix, whereby the exterior surface of the fibers is substantially devoid of fibrils. Fibers made by the process of the invention are useful as carpet face yarn, in textiles, upholstery and other industrial applications, like chemical industry and others.
Patent AU-2002210773-B2 (AU)
Title: Thermally stable binder resin composition and method for binding fibres
Inventor: FARO CARMELO LO
IPC: D06M15/63
Filed: 2001-11-06
Granted: 2006-02-09
Abstract: A resin binder composition for the production of a fiber preform comprising an amount of at least one polyarylether thermoplast resin component and an amount of at least one thermoset resin component in weight ratio 80/20-10/90, in substantial absence of a catalyst which is active at the prevailing preform production temperature, wherein the polyarylether thermoplast has number average molecular weight (Mn) in the range 2,000-20,000, and comprises ether linked phenyl units and ether linked arylsulphone units and reactive end groups, method for producing a fiber preform using the thermally stable binder resin composition, a perform obtained with use of the method and composition, a method for injecting or infusing the preform with curable matrix resin, the curable injected or infused preform resin, a method for curing thereof and a cured composite obtained with the method.
Patent AU-2002233618-B2 (AU)
Title: Peptides from the 16/6Id antibody for treating SLE
Inventor: MOZES EDNA
IPC: A61K38/00
Filed: 2002-02-26
Granted: 2006-12-21
Abstract: Synthetic peptides of at least 12 and at most 30 amino acid residues comprising a sequence consisting of, or found within, a complementarity-determining region (CDR) found in the heavy or light chain of the human anti-DNA 16/6Id monoclonal antibody, or a sequence obtained by replacement and/or deletion and/or addition of one or more amino residues to said sequence, and salts, chemical derivatives and polymers of said peptides can be used for immunomodulation of systemic lupus erythematosus-associated responses.
Patent AU-2002301325-B2 (AU)
Title: Improved interference screw having increased upper diameter
Inventor: WEST HUGH S
IPC: A61F2/08
Filed: 2002-10-07
Granted: 2007-06-14
Abstract: An interference screw for affixing soft tissue grafts during anterior cruciate ligament (ACL) reconstruction comprises a threaded body axially extending between a face and a tip along a central axis, with the face advantageously being obliquely aligned with the central axis. The threaded body includes a proximal threaded section and a distal threaded section, each of which may be straight or tapered. The proximal threaded section is approximately 1 mm larger in diameter than the distal threaded section. The increased diameter of the proximal threaded section enables the interference screw to compressively secure the soft tissue graft against the cortical bone, while the distal threaded section compresses the soft tissue graft against the cancellous bone with an appropriately reduced force that is appropriate for facilitating bonding of the soft tissue graft to the cancellous bone and that is sufficient for minimizing any "bungee effect." <IMAGE>
Patent AU-2002304478-B2 (AU)
Title: Method and device for diffusing a protective flux with regard to a surrounding environment
Inventor: BRIDENNE PIERRE
IPC: F24F9/00
Filed: 2002-05-14
Granted: 2007-03-15
Abstract: Device and method for diffusing a protective flux. In order to protect one area of a service station, a more or less parallel air flow is created in the direction of the area. Above a threshold F, the air flow has a gradually increasing speed V 22 and, below the threshold, the air flow speed V 21 is more or less uniform along the length of a flow section in a plane P which is transverse to the direction of flow D. One possible configuration for an air flow diffusion device, which allows a confinement barrier to be created, consists of a diffusing wall comprising a main wall and a lateral wall. The main planar wall is adapted to diffuse a main laminar flow in the sterile area to be protected. The lateral wall is adapted to diffuse a lateral flow divergent from the main flow. A skirt is disposed to create an obstacle to the lateral flow and to accelerate the flow by of deflection.