Patent SG-11201806980T-A (SG)
Title: Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof
Inventor: LE HIR DE FALLOIS LOIS
IPC: C07D261/04
Filed: 2017-02-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 31 August 2017 (31.08.2017) WIPO I PCT (10) International Publication Number WO 2017/147352 Al 111111111111110111011111111111010111110111010111011111011111111011111111111110111111 (51) International Patent Classification: A01N 43/80 (2006.01) A01P 3/00 (2006.01) CO7D 261/04 (2006.01) A61K 9/00 (2006.01) AO1P 7/04 (2006.01) A61K 47/00 (2006.01) AO1P 7/02 (2006.01) A61K 31/422 (2006.01) (21) International Application Number: PCT/US2017/019239 (22) International Filing Date: 24 February 2017 (24.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/299,333 24 February 2016 (24.02.2016) US 62/379,348 25 August 2016 (25.08.2016) US (71) Applicant: MERIAL, INC. [US/US]; 3239 Satellite Blvd., Duluth, GA 30096 (US). (72) Inventors: LE HIR DE FALLOIS, Lois, Patrick; 2259 Fairhaven Circle NE, Atlanta, GA 30305 (US). MENG, Charles, Q.; 2291 Chance Lane, Grayson, GA 30017 (US). CADY, Susan, Mancini; 1501 Revere Road, Yard- ley, PA 19067 (US). CHEIFETZ, Peter; 15 Lynnfield Drive, East Windsor, NJ 08520 (US). GALESKA, Iza- bela; 1725 Triten Dr, Newtown, PA 18940 (US). (74) Agent: JARECKI-BLACK, Judy; 3239 Satellite Blvd., Duluth, GA 30096 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 17 / 147 35 2 Al (54) Title: ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF (57) : This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.