baber/WOPTO huggingface dataset:
Patent CA-2516685-A1 (CA)
Title: Peptidomimetic inhibitors of stat3 activity and their medical uses
Inventor: JOVE RICHARD
IPC: C07K5/08
Filed: 2004-02-20
Abstract: The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function.  Peptidomimetics of the invention include dipeptides of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position and L=Leu, Val, Ala or a non-polar amino acid. R is preferably aryl or heteroaryl, eventually substituted with halogens, amino and nitro groups. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.
Patent CA-2517512-A1 (CA)
Title: Polymeric crosslinkable compositions containing acetal amides
Inventor: BARSOTTI ROBERT
IPC: C08G18/38
Filed: 2004-04-02
Abstract: Polymeric compositions containing amide acetal groups are crosslinked by hydrolyzing the amide acetal groups, and the hydroxyl groups and/or the amines functions that are formed are reacted to crosslink the composition.
Patent CA-2518875-A1 (CA)
Inventor: DRAYER FRIEDRICH
IPC: F16G11/00
Filed: 2005-09-13
Abstract: The invention relates to a webbing device for arrangements which are put under tensile load, particularly for systems for the securing of tree crowns, having a webbing (10) with a loop at each end (12, 12') which is formed by turning over the end parts of the webbing (10) and fastening the ends to the webbing, wherein the fastenings (14, 14') and the webbing (10) are adapted to withstand a pre-determined minimum tensile force.  In order to guarantee a good visibility of the indicating element even from greater distances, it is proposed by the invention that the webbing (10) is overlapped by an indicating element (16) in the vicinity of at least one of the loops (12), which indicating element shortens the webbing (10) and is fastened with two end portions on the webbing (10) such that one of the fastenings (18) gives way when a pre-determined tensile force acts on the webbing (10), the tensile force being smaller than the minimum tensile force which the loop fastenings (14, 14') and the webbing withstand.
Patent CA-2520034-A1 (CA)
Title: Beacon docking system with visual guidance display
Inventor: HUTTON NEIL
IPC: B64F1/305
Filed: 2004-03-23
Abstract: Disclosed is a system and method for automatically aligning an end of a passenger boarding bridge (1) with a doorway of an aircraft (21). A beacon signal and a control signal are transmitted from a predetermined location aboard the aircraft (21), such as within a window proximate a doorway (20) of the aircraft (21). The beacon is sensed and from the sensed beacon a direction for moving of the end of the passenger boarding bridge is determined. The passenger boarding bridge (1) is then moved according to the determined direction and the control signal. The process is iterated until the docking of the bridge (1) to the aircraft (21) is completed.
Patent CA-2521407-A1 (CA)
Title: Polymeric drug agents for the treatment of fibrotic disorders
Inventor: PUTNAM CHARLES L
IPC: A61K/
Filed: 2004-03-30
Abstract: Agents and methods for treatment of adhesions and fibrotic diseases, through the release of drugs that retard or inhibit fibrotic tissue production. A  method for releasing fibrotic tissue-inhibiting agents from a polymer is provided. The polymer/drug combination can be applied directly to affected site as a liquid, gel, or paste. Alternatively, the polymer/drug combination can be injected ( intravenous, intraperitoneal, or subcutaneous) in an appropriate vehicle.
Patent CA-2522157-A1 (CA)
Inventor: NACCARATO JOSEPH
IPC: G02B21/00
Filed: 2004-04-05
Abstract: The system has a light source (10) providing an incident light beam (11) illuminating an ophthalmic lens (2). A reflecting unit (15) and a collimation and magnification lens (14) are arranged downstream and upstream from the lens (2), respectively on an optical path of the beam. The reflecting unit includes a set of reflecting planar faces (16) arranged in the form of a cube with its corner opened in direction of the lens (2). Independent claims are also included for the following: (a) a device for buffing of ophthalmic lens (b) a method of orientation of ophthalmic lens.
Patent CA-2526670-A1 (CA)
Title: Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
Inventor: OTANI ATSUSHI
IPC: A61K35/12
Filed: 2004-04-28
Abstract: Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin-HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin-HSCs express the cell surface antigen CD31. The isolated Lin-HSC populations are useful for treatment of ocular vascular diseases. In a preferred embodiment, the Lin-HSCs are isolated by extracting bone marrow from an adult mammal; separating or plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin HSC population containing EPCs. Isolated Lin-HSCs that have been transfected with therapeutically useful genes are also provided, and are useful for delivering genes to the eye for cell-based gene therapy. Methods of preparing isolated stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.
Patent CA-2528703-A1 (CA)
Title: Method of reducing rms load voltage in a lamp using pulse width modulation
Inventor: WEYHRAUCH ERNEST C
IPC: H05B37/00
Filed: 2005-12-02
Abstract: A method of converting a line voltage to an RMS load voltage in a lamp includes modulating a load voltage with a pulse width modulation circuit that is entirely within the lamp and provides an RMS load voltage to a light emitting element of the lamp. Conduction is triggered in the pulse width modulation circuit independently of a line voltage magnitude with a time-based signal source that defines a duty cycle of the pulse width modulation circuit suitable for the RMS load voltage.
Patent CA-2529279-A1 (CA)
Inventor: MARTIN WILLIAM WESLEY
IPC: F16H59/36
Filed: 2004-07-08
Abstract: A transmission having a plurality of gear ratios (15, 17), selector means (13) for selectively engaging the gear ratios, clutch means (2) for selectively transmitting drive from a drive source to the transmission, and a control system for controlling a clutch torque limit, said control system being constructed and arranged to automatically adjust the clutch torque limit value before the selector means selects an unengaged gear ratio, to allow relative rotational movement between input and output sides of the clutch if the torque exceeds the predetennined value when the unengaged gear ratio is engaged by the selector means.
Patent CA-2529812-A1 (CA)
Inventor: KOPIA GREGORY A
IPC: A61F2/86
Filed: 2005-12-12
Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials.     Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism.  In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment.      Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Implantable medical devices may be coated or otherwise have affixed thereto agents for healing ischemic tissue.
Patent CA-2534001-A1 (CA)
Inventor: VAES ED
IPC: E04F19/02
Filed: 2006-01-23
Abstract: The present invention is a multi piece curved molding including at least two curved sections adapted to butt together at an abutting joint. It further includes a flexible hinge for connecting the curved sections together at the joint for operably folding and unfolding the curved sections. Preferably it also includes a wafer for connecting two abutting curved sections at an abutting joint.
Patent CA-2535324-A1 (CA)
Inventor: DAVIS DAVID T
IPC: A61G7/08
Filed: 2004-08-03
Abstract: A transfer mattress is provided including a top sheet having a width, a length, and longitudinally oriented peripheral edges and a bottom sheet havi ng the same width, the same length, longitudinally oriented peripheral edges an d a plurality of perforations. The longitudinally oriented peripheral edges of the top and bottom sheets are sealingly fastened to one another often by hea t sealing. A plurality of baffles, each having a width and a length, are attached to an inner surface of the top sheet and an inner surface of the bottom sheet so as to be transversely oriented between the top sheet and the bottom. The baffles along with the widths of the top and bottom sheets defin e a radially-outwardly curved perimeter wall that is disposed between an edge of the baffles and the sealed peripheral edges of the top and bottom sheets. Th e radially-outwardly curved perimeter wall has a width y that is determined by the following relationship: formula (I) where d comprises a height of the longitudinally extensive pontoon and x comprises the width of the baffles.</ SDOAB>
Patent CA-2540319-A1 (CA)
Title: Wrapped pile weatherstripping and methods of making same
Inventor: ALBANESE JAMES V
IPC: B32B3/02
Filed: 2003-10-15
Abstract: Pile weatherstripping, which is clad with a wrapping of a film (14, 25, 104, 216) of flexible material, has one or more rows (19, 27, 100, 102, 212, 214) of pile (10, 24, 105, 233) on a backing (12, 28, 106, 218) in side-by-side relationship. The wrapping film material conforms to the outside surface of the row (19, 27, 100, 102, 214) of pile so as to define a bulb or bulbs which are completely filled with pile. Single row (19, 27) pile weatherstripping is made by wrapping the pile (10, 24) with the film material (14, 25) after first ultrasonically welding the film material along one edge thereof to the backing (12, 28) under the pile. Then, the film material (14, 25) may be bent around the pile as it moves through a guide (88). The film material (14, 25) is then attached along the opposite edge to the backing thereof so as to completely enclose and clad the row (19, 27) of weatherstripping. The film material may be wrapped around one row (214) of two adjacent rows (212, 214) of pile (233) and attached to the backing (218), leaving the other row (212) unclad. The film material (104) may be wrapped separately around adjacent rows and attached to the backing (106) to provide two clad rows (100, 102) of weatherstripping. By selection of the porosity of the film material (14, 25, 104, 216) and the density of the pile (10, 24, 105, 233), weatherstripping having desired compressibility and air and water infiltration control properties may be produced.
Patent CA-2542834-A1 (CA)
Title: Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents
Inventor: MCTAVISH HUGH
IPC: A61K45/00
Filed: 2004-10-21
Abstract: The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent.
Patent CA-2544120-A1 (CA)
Inventor: CROAK MARIAN
IPC: H04Q3/64
Filed: 2006-04-19
Abstract: A method and apparatus for enabling a user to signal to the network that a call to be initiated or a call that is in progress needs to occur in a peer-to-peer relationship with the terminating endpoint. The network will then remove itself from the call signaling and media path and direct the signaling and media communication to occur directly between the two endpoints.
Patent CA-2549742-A1 (CA)
Inventor: GREENWALD ZIPORA
IPC: G05D23/00
Filed: 2006-06-09
Abstract: A beverage dispenser and method of operation, in which incoming water for beverage preparation is heated by a liquid-to-liquid heat exchanger. The heated water may be mixed with cold water using controlled valves, to generate a selected temperature stream. This controlled-temperature stream may be mixed with beverage concentrate or sprayed over coffee grounds to brew fresh coffee.
Patent CA-2549895-A1 (CA)
Title: Hydrodynamic static mixing apparatus and method for use thereof in transporting, conditioning and separating oil sands and the like
Inventor: CYMBALISTY LUBOMYR M
IPC: B01F5/06
Filed: 2003-12-17
Abstract: A static hydrodynamic mixer undulating interior conduit provides a static mixing apparatus which utilizes a spiral, coiled or curved conduit to cause dynamic mixing of flowing fluids while they are pumped through the conduit. The conduit is formed wherein the diameter of the conduit is greater than the diameter of the helix forming the coil. Gentle but pervasive low-shear mixing is produced by axial and radial secondary currents induced by gravitational and centrifugal body forces acting on the solid and liquid fluid components flowing through the undulating conduit. The vigor of mixing and resistance to flow increases with the undulation's amplitude/pitch ratio. The application includes a method of use in extracting bitumen from oil sands.
Patent CA-2550238-A1 (CA)
Title: Plastic collapsible bottle with accordion-like arranged bellows ridges
Inventor: MUSALEK OTO
IPC: B65D1/02
Filed: 2004-12-02
Abstract: The bottle has accordion-like collapsible bellows ridges (1) with upper and lower arched shape surfaces (1~, 1~~), always only one of the surfaces (1~, 1~~) is provided with a system of ridge embossed or stamped stiffenings (2) without horizontal continuity. System of vertical stamped stiffenings (3) is present as well, creating recesses (4) of the bellows ridges (1) with angle greater than 90~, having arched shape haunches (5) at the top and bottom.  Stacking depression (6) is created in the bottom of the bottle, the bottle is preferably provided with removable label leaving no residue and it has completely detachable cap (7).
Patent CA-2555139-A1 (CA)
Title: Air bath
Inventor: WANG DIANA
IPC: A61H33/06
Filed: 2005-02-03
Abstract: An air bath has air jets arranged in rows extending around the side walls of the water basin. The rows of air jets are spaced vertically so that they are at different heights within the basin and so that air jets in the higher row(s) realize less pressure from the water in the basin. Air is delivered to the air jets through a ring-like air manifold formed of a single channel or multiple channels, the latter allowing for air flow control to different zones of the tub.
Patent CA-2556317-A1 (CA)
Inventor: GENDLINA LUDMILA I
IPC: C25C3/08
Filed: 2006-08-16
Abstract: A method of forming a lining layer in a cathode shell of an electrolytic aluminum cell including the following steps: filling the cathode shell with a powdered material, leveling of said powdered material, positioning of a layer of dust-insulating material and conducting steps of static and dynamic compaction. In the static compaction step, a working element of static compaction is successively moved over the lining layer. In the step of dynamic compaction, a working element of dynamic compaction is moved over the entire width of the lining layer with the static load being continuously applied on the working element of dynamic compaction.
Patent CA-2557232-A1 (CA)
Inventor: DEWE JORY
IPC: F16B7/04
Filed: 2006-08-11
Abstract: A tube clamp apparatus designed to be part of a moveable or portable structure, such as a large telescope, and having a truss clamp body and a hand wheel with a clamping screw integrally connected thereto. Two holes are drilled, one into the intended clamping surface for the insertion of a tapped hole or a threaded insert, and the other through the truss tube. The body of the tube clamp apparatus is then placed over the tube, the holes are aligned, and the hand wheel is installed , the hand wheel passing through the clamp body and the tube center, and into the intended clamping surface. By virtue of the cylindrical design of the body, and with only one fastener at its center, the tube clamp apparatus can be set at any angle within a 360 degree arc, along the plane of the clamping surface, and can withstand high radial loads.
Patent CA-2558501-A1 (CA)
Inventor: GOMES FRANCHINI KLEBER
IPC: A61K31/517
Filed: 2004-10-07
Abstract: The present invention introduces compounds that are adenosine-kinase inhibitors. We provide a process of protecting tissues and organs like heart, brain and kidneys affected by ischemia, and of treating heart insufficiency, myocardium infarct, arrhythmia, arterial hypertension, atherosclerosis, coronary artery re-stenosis after angioplasty, chronic renal insufficiency, cerebral vascular accident, and chronic inflammatory diseases (e.g. rheumatoid arthritis). We also provide the adenosine-kinase inhibitor effect of compounds derived from quinazolines, which were previously known as reversible inhibitors of tyrosine-kinases from the family of epidermic growth factor receptors (EGFR).
Patent CA-2559074-A1 (CA)
Inventor: FOUAD HAGSERESHT
IPC: E01H15/00
Filed: 2005-03-09
Abstract: A modified substrate for removing aqueous oxyanions formed by: selecting a substrate from minerals or mineral equivalents having a naturally moderate to high cation exchange capacity; forming a substrate modifier from salts of the Group IIIB and Group IVB elements by dissolving one or more of the salts in water at an elevated temperature; and blending the substrate with the substrate modifier at a high shear rate.
Patent CA-2559946-A1 (CA)
Title: Coating of a polymer layer using low power pulsed plasma in a plasma chamber of a large volume
Inventor: COULSON STEPHEN RICHARD
IPC: B05D1/08
Filed: 2005-03-18
Abstract: A method for depositing a polymeric material onto a substrate, said method comprising introducing an organic monomeric material in a gaseous state into a plasma deposition chamber, igniting a glow discharge within said chamber, and applying a high frequency voltage as a pulsed field, at a power of from 0.001 to 500w/m3 for a sufficient period of time to allow a polymeric layer to form on the surface of the substrate. The method is particularly suitable for producing oil and water repellent coatings, in particular where the monomeric material contains haloalkyl compounds. Apparatus particularly adapted to carry out the method of the invention is also described and claimed.
Patent CA-2560549-A1 (CA)
Title: Satellite diversity system, apparatus and method
Inventor: SCHIFF LEONARD N
IPC: H04B7/185
Filed: 2005-03-15
Abstract: Communication diversity using a plurality of satellites is disclosed. The satellites can support multiple regions corresponding to multiple satellite beams. Each satellite can support all regions in the reverse direction and each satellite can be designated as a primary satellite for one of the multiple regions corresponding to one of the multiple satellite beams. Each satellite can receive from any of the regions reverse link signals broadcast by, for example, a mobile station. Each satellite can communicate the received reverse link signals to, for example, a base station or gateway where the signals can be combined to increase signal quality. A mobile station receives forward link signals from the primary satellite and monitors a signal quality from the primary satellite and from a secondary satellite. If the signal quality from the primary satellite drops below a threshold value, the communication signal is transferred to the secondary satellite.
Patent CA-2562207-A1 (CA)
Inventor: LIU WEI
IPC: B60Q1/54
Filed: 2006-09-28
Abstract: My invention is a New Type of Vehicle's Rear Speed Lights. It shows speed of a vehicle to other drivers; helps to keep a safer distance between vehicles, reducing the chances of accidents. Such new type of vehicle's rear speed lights is an upgrade based on the high-mount brake light of vehicles, the device is made up of 32 horizontal small lights (Drawing A, A-1, A-2, A-3, A-4, A-5) or 16 (16 layers) upright small lights (Drawing B, B-1, B-2) in a casing with a red outer covering.  The shade and the structure of this device is similar to the high-mount brake light, equipped at the same place on vehicles with the high-mount brake light, but the function and usage differs greatly.
Patent CA-2562518-A1 (CA)
Title: Method for temporal inversion of a wave
Inventor: LEROSEY GEOFFROY
IPC: H03D7/00
Filed: 2005-04-11
Abstract: According to the invention, a wave, corresponding to a signal s(t), may be temporally inverted by application of a first transformation to lower the central frequency thereof to produce a first set of transformed signals Ki(t), then a second set of transformed signals K'i(t) is produced, representing the temporal inversion signal s(-t) and a third transformation is applied to said second set to generate the temporally-inverted signal s (-t) .
Patent CA-2563374-A1 (CA)
Title: Antagonism of tgf-.beta.superfamily receptor signaling
Inventor: VALE WYLIE
IPC: C07K/
Filed: 2005-04-27
Abstract: Members of the TGF-.beta. superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-.beta. ligands including activins, myostatin, BMPs and nodal.  Methods are described for the screening and identification of antagonist for TGF-.beta. superfamily members, in particular activin-A antagonist.
Patent CA-2567317-A1 (CA)
Title: Device for preventing cribbing or wind sucking in horses
Inventor: BARCLAY RICHARD
IPC: A01K15/02
Filed: 2005-05-21
Abstract: An electric shock device (80) in use attached to an animal such as a horse or other equine animal to discourage an undesirable behaviour such as wind-sucking. The device (80) includes: an attachment (81) for locating the device (80) on the neck of the animal; an electric charge source (90) operatively connected to the attachment (81); electrode means (95) for applying an electric pulse to the animal, the electrode means (95) electrically connected to the charge source (90); and activation means such as a hinged lever or tongue (84) activated in response to the performance by the animal of the undesirable behaviour alone, the activation of the activation means (84) leading to the discharge of said electric pulse from said electric charge source (90).