Patent SG-11201808809P-A (SG)
Title: Therapeutic hpv vaccine combinations
Inventor: CUSTERS JEROME
IPC: C07K14/025
Filed: 2017-05-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 011101011M HO 11111 0 I 01111101010111110111110111011 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192418 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: (NL). KHAN, Selina; c/o Janssen Vaccines & Prevention A61K 39/12 (2006.01) C07K 14/025 (2006.01) B.V., Archimedesweg 4, 2333 CN Leiden (NL). KALLA, (21) International Application Number: Markus; Wolfl 6c, 823777 Penzberg (DE). WEIDNER, PCT/US2017/030338 Katrin; Lessingstrasse 6c, 93049 Regensburg (DE). (22) International Filing Date: (74) Agent: SIMS, Sara E. et al.; Panitch Schwarze Belisario 01 May 2017 (01.05.2017) & Nadel LLP, One Commerce Square, 2005 Market Street, Suite 2200, Philadelphia, PA 19103 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/330,562 02 May 2016 (02.05.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/447,094 17 January 2017 (17.01.2017) US DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (71) Applicants: JANSSEN VACCINE & PREVENTION KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, B.V. [NL/NL]; Archimedesweg 4, NL-2333 CN Leiden MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (NL). BAVARIAN NORDIC A/S [DK/DK]; Hejreskowej PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 10A, DK-3490 Kvistgaard (DK). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (72) Inventor; and TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for US only): BUNNIK, Evelien M. [NL/US]; (84) Designated States (unless otherwise indicated, for every _ 1105 County Road 2720, Mico, TX 78056 (US). kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: CUSTERS, Jerome, H.h.v.; c/o Janssen Vac- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = cines & Prevention B.V., Archimedesweg 4, 2333 CN Lei-TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, den (NL). SCHEPER, Gerrit C.; c/o Janssen Vaccines — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = & Prevention B.V., Archimedesweg 4, 2333 CN Leiden (54) Title: THERAPEUTIC HPV = _ = — <c.• = 100 kDa — = 75 kDa — = = = 50 kDa — = 37 kDa — = 1-1 GC 11 7r c ei 1-1 IN 1-1 0 ei • 2' (e, , A G ' ( t, , VACCINE COMBINATIONS (57) : Vectors, vaccines, vaccine compositions and vaccine combinations for use as therapeutics against HPV18 and/or HPV16 are described. Ne Anti-H PV16 E7 Anti NF-kB Fig. 1 C [Continued on next page] WO 2017/192418 Al MIDEDIM01101 DIDIRMEM300101111111111111101111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))