baber/WOPTO huggingface dataset:
Patent IL-105287-A (IL)
Title: Peptides with n-terminal modifications having bradykinin antagonist activity process for their preparation and pharmaceutical compositions containing them
IPC: A61K38/08
Filed: 1993-04-02
Abstract: Peptides of the formula I  Z - P - A - B - C - E - F - K - (D)Q - G- M- F' - I (I),  in which   Z is optionally substituted (cyclo)alk(ano)yl(sulphonyl), (C1-C8)-alkoxycarbonyl, (hetero)ar(o)yl(sulphonyl), carbamoyl,   P is a direct linkage or a radical II  -NR<2>-(U)-CO- (II> in which   R<2> is H, methyl or a urethane protective group,   U is (cyclo)(aryl)alkylidene, (hetero)arylidene or (CHR<3>)n,   R<3> is hydrogen, (cyclo)alkyl, (hetero)aryl, or in which R<2> and R<3> form, together with the atoms carrying them, a ring system;   A is defined as P;   B is a basic amino acid in the L or D configuration,   C is a compound of the formula IIIa or IIIb  G'-G'-Gly (IIIa> G'-NH-(CH2)p-CO (IIIb> in which p is 2 to 8 and   G' are, independently of one another, a radical of the formula IV -NR<4>-CHR<5>-CO- (IV> in which R<4> and R<5> form, together with the atoms carrying them, a heterocyclic ring system; E is the residue of a neutral, acid or basic, aliphatic or alicyclic-aliphatic amino acid; F are, independently of one another, the radical of a neutral, acid or basic, aliphatic or aromatic amino acid, or a direct linkage; (D)Q is D-Tic, D-Phe, D-Dic, D-Thi or D-Nal, or a radical of the formula (V) <IMAGE> in which X is O, S or a direct linkage, and R is H, (cyclo)alkyl or aryl(alkyl),   G is defined as G' above or is a direct linkage; F' is defined as F, is a radical -NH-(CH2)q- with q = 2 to 8 or, if G is not a direct linkage, can be a direct linkage, and   I is -OH, -NH2 or NHC2H5; K is the radical -NH-(CH2)x-CO- with x = 1-4 or is a direct linkage, and   M is defined as F  and their physiologically tolerated salts are described. They have excellent bradykinin-antagonistic action. They are obtained by reacting a fragment with a C-terminal free carboxyl group or its activated derivative with an appropriate fragment with an N-terminal free amino group, or by assembling the peptide stepwise, eliminating one or more protective groups temporarily introduced where appropriate to protect other functionalities in the compound obtained in this way, and converting the compounds of the formula I obtained in this way where appropriate into their physiologically tolerated salt.
Patent IL-106076-A (IL)
Title: Alpha anomer enriched mixture of 3,5-bis (protected hydroxy)-2-deoxy-2,2-difluoro-d-ribofuranosyl-1-alkyl-(oraryl)-sulfonates and their preparation at low temperatures
IPC: C07H13/08
Filed: 1993-06-21
Abstract: A stereoselective process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates by contacting a lactol with an base in an inert solvent, adjusting the temperature and adding a sulfonating reagent.
Patent IL-107913-A (IL)
Title: Digital cable headend for cable television delivery
IPC: H04H20/86
Filed: 1993-12-07
Abstract: A method for distributing programs to subscribers in a cable television system characterized in that digitized programs are selected and combined for distribution to program subscribers, the method including the steps of: receiving information on programs to be selected for distribution to the program subscribers; selecting the digitized programs based on the received information; combining the selected programs into a combined signal; and distributing the combined signal to the subscribers.
Patent IL-111028-A (IL)
Title: 4-hydroxyalkyl-indol-2-ones
IPC: C07C69/025
Filed: 1991-04-16
Abstract: A process for the preparation of a compound of structure (I), in which n is 1 to 3 and each group R is hydrogen or alkyl, which comprises, reaction of a compound of structure (II), in which R<1> is alkyl, phenyl or substituted phenyl and n is 1 to 3, with an amine HNR2 in which R is as described for structure (I), and optionally thereafter forming a salt.
[WO9116306A1]
Patent IL-121209-A (IL)
Title: Secure file system
IPC: G06F13/00
Filed: 1997-07-01
Abstract: A method of performing a file access, comprising the steps, performed by a system having a memory, of: receiving an indication that an entity desires to perform a file access operation on a file of the data processing system; obtaining a cryptographic affidavit of the file; checking that the cryptographic affidavit is acceptable in accordance with a user signature data structure stored in the memory; checking that the cryptographic affidavit is acceptable in accordance with a system signature data structure stored in the memory; and allowing the file access when the cryptographic affidavit is acceptable in accordance with both the user signature data structure and the system signature data structure. 3109 ח' בטבת התשס" ב - December 23, 2001 3110 ח' בטבת התשס" ב - December 23, 2001
Patent IL-125256-A (IL)
Title: N-(3,3- DIMETHYLBUTYL)-L-ASPARTYL-D-α-AMINOALKANOIC N-(S)-1-PHENYL-1-ALKANAMIDE USEFUL AS A SWEETENING AGENT AND PROCESS FOR ITS PREPARATION
IPC: A23L27/30
Filed: 1997-02-07
Abstract: Compounds of the formula in which: Y is C2H5, CH(CH3)2 or (R) CH(OH)CH3; and R) is (S) CH(C2H5)C6H5, (S) CH(CH3)C6H5 or (R) CH(CH2OCH3)C6H5.
Patent IL-125596-A (IL)
Title: Sustained delivery of an active agent using an implantable system
IPC: A61K38/00
Filed: 1997-01-15
Abstract: An implantable device for delivering an active agent to a fluid environment of use comprising: (a) a fluid-impermeable housing defining a reservoir (12) and provided with a piston (16) which piston divides the reservoir into a first chamber (18) and a second chamber (20), the first and second chambers each having an open end; (a) a water-swellable agent formulation in the first chamber; (c) an active agent formulation in the second chamber; (d) a semipermeable plug (24) in the open end of the first chamber; and (e) a back-diffusion regulation outlet valve (22) provided in the open end of the second chamber; wherein said device effectively seals the second chamber and isolates the active agent formulation from the environment of use.
Patent IL-129287-A (IL)
Title: Axisymmetric vectoring nozzle actuating system having multiple power control circuits
IPC: F02K1/00
Filed: 1996-10-16
Abstract: A failsafe nozzle actuating system for an aircraft gas turbine engine axisymmetric vectoring exhaust nozzle having a vectoring ring (86) operably linked to a plurality of pivotal flaps which are circumferentially disposed about a nozzle centerline and bounding an exhaust gas flow path in the nozzle, said failsafe nozzle actuating system comprising: a first vectoring actuating system having a first group of actuators (90A) operably connected to said vectoring ring and a first failsafe control means to control power to said first group of actuators, a second vectoring actuating system having a second group of actuators (90B) operably connected to said vectoring ring and a second failsafe control means to control power to said second group of actuators, and said actuators of said first group are interdigitated with said actuators of said second group around the nozzle. 2726 י" ד בחשון התשס" ב - October 31, 2001
Patent IL-130284-A (IL)
Title: Zinc alloys yielding anticorrosive coatings on ferrous materials
IPC: C23C2/06
Filed: 1997-12-23
Abstract: Zinc alloy intended for anti- corrosive coatings on ferrous materials, consisting of 0-0.25% aluminium, 0-1.2 % lead, 0.001-0.6% nickel and 0.001-0.6% vanadium, balance being zinc and usual impurities.
Patent IL-141935-A (IL)
Title: Method of luring an animal to a predetermined place
IPC: A01K1/00
Filed: 2000-07-18
Abstract: The invention relates to a method of luring an animal to a predetermined place, such as e.g. a milking stall and/or a feeding stall, where the animal lured undergoes a predetermined treatment, and/or a predetermined animal-related action, such as e.g. milking and/or feeding, is performed, whereby, at least during a predetermined stage of the treatment and/or the action, at least one previously defined climate parameter is set artificially in at least one part of the relevant place. <IMAGE>
Patent IL-144539-A (IL)
Title: Arrangement for charging energy in an energy-storing arrangement such as an ignition capacitor
IPC: F42C15/40
Filed: 2001-07-24
Abstract: The present invention provides an arrangement for charging energy in an energy-storing arrangement such as an ignition capacitor in electronic ignition systems. To reduce the risk of malfunction, direct-current-controlled breakers controlled by environmental conditions, normally occurring on the primary side of a transformer (4) in series with the primary winding (5) have been replaced by a frequency divider (2) controlled by environmental conditions. This frequency divider divides down a signal supplied by a signal generator (1) pulse train with a lower frequency which controls a breaker (7) connected in series with the primary winding (5) of the transformer.
Patent IL-167069-A (IL)
Title: Topical composition comprising metronidazole or a derivative thereof
Inventor: ARMSTRONG DAVID NIGEL
IPC: A61K47/06
Filed: 2005-02-23
Abstract: A topical composition comprising about 5 wt % to about 12.5 wt % of metronidazole or a pharmacologically acceptable salt thereof in a non-aqueous vehicle. The composition may be used in the treatment of skin damage due to inflammatory skin conditions; thermal, chemical or electrical burns; infections or radiation treatment. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect, and thus, side effects observed from systemic administration are avoided.
Patent IL-172203-A (IL)
Title: Methods of screening pharmaceutical compounds useful for treating and/or preventing acute or chronic pain
IPC: G01N33/50
Filed: 2005-11-27
Abstract: Using sphingosine-1-phosphate (S1P), its fragments or derivatives in the preparation of pharmaceutical compounds, for the modulation of pain and for identifying compounds that modulate pain, is new. Independent claims are also included for: (1) screening pharmaceuticals useful for modulating or preventing pain involving: either providing a sample containing protein associated with Myc (PAM), its functional fragment or derivative and not containing S1P, providing a second sample containing PAM, its functional fragment or derivative and containing S1P, measuring the PAM activity in both samples, contacting the first sample with a compound, and determining the ability of the compound to mimic S1P function; or providing two samples comprising a cell expressing an S1P receptor, its functional fragment or derivative, contacting one sample with the compound and measuring or comparing the receptor activity in both samples; or providing two samples comprising a cell expressing S1P receptor, its functional fragment or derivative, contacting the samples with S1P, contacting one sample with the compound and measuring the receptor activity or the interaction of S1P and receptor in both samples; or: (a) providing a cell expressing S1P and PAM or their functional fragment or derivative; (b) contacting the cell with a compound; (c) determining the S1P activity in the presence or absence of compound; and (d) comparing the S1P activity; and (2) identification of a compound that modulates pain involving selecting a compound that modulates or mimics the activity of S1P as a test compound, administering the test compound to a subject, and determination of pain modulation in the subject. ACTIVITY : Analgesic; Antiinflammatory. To determine the analgesic effect of sphingosine-1-phosphate (S1P). S1P was delivered to the spinal cord by intrathecal injection. Rats were anesthetized with ketamine (60 mg/kg intraperitoneally) and midazolam (0.5 - 1 mg/kg intraperitoneally). The skin was incised and catheter was fixed with cyanacrylate glue. Three days after surgery rats were placed into a freely moving system, and 10 MicroM S1P (20 Microl) infused through the catheter. Within 15 minutes after stopping the infusion the formalin test was performed. 5% Formaldehyde solution (50 Microl) was injected subcutaneously. Flinches were counted in one minute intervals up to 60 minutes starting right after formalin injection. Flinches of 5 minutes intervals were counted over a period of 60 minutes. A significant decrease in the number of nociceptive responses for phase 2A (20 - 35 minutes after formalin injection) and detected as compared to phosphate buffer saline/dimethylsulfoxide-treated animals. The results showed that the exogenous S1P acts as an analgesic. No specific results are given. MECHANISM OF ACTION : Adenylyl cyclase (AC) (preferably type I, V or Vf) activity inhibitor; Sphingosine-1-phosphate (S1P) receptor binder.
Patent IL-193129-A (IL)
Title: Composition for the treatment of disorders and ailments of the gastrointestinal tract
Inventor: DANIELKATZ
IPC: A61K/
Filed: 2008-07-29
Abstract: The invention discloses a pharmaceutical composition useful for treatment and prevention of medical disorders and ailments. The aforesaid composition comprises active ingredients comprising; Turmeric extract, Turmeric powder, optionally, Selenium or source of Selenium, especially Selenomethionine, optionally, Green tea extract. The pharmaceutical composition further comprises enteric coating encapsulating the same. The disclosed pharmaceutical composition is especially adapted for treatment of inflammatory bowel disease (IBD) and colorectal cancer (CRC).
Patent IL-202483-A (IL)
Title: Vanadium-drier intaglio ink
IPC: B41M/
Filed: 2009-12-03
Abstract: An oxidatively curing intaglio printing ink is disclosed, comprising an oxidatively curable polymer, an anionic macromolecular surfactant, a wax component, and a salt of vanadium, preferably of the vanadyl (VO 2+ ) ion, as the oxypolymerisation inducing siccativating agent.
Patent IL-215254-A (IL)
Title: Audio decoder and decoding method using efficient downmixing
IPC: G10L/
Filed: 2011-09-20
Abstract: A method, an apparatus, a computer readable storage medium configured with instructions for carrying out a method, and logic encoded in one or more computer-readable tangible medium to carry out actions. The method is to decode audio data that includes N.n channels to M.m decoded audio channels, including unpacking metadata and unpacking and decoding frequency domain exponent and mantissa data; determining transform coefficients from the unpacked and decoded frequency domain exponent and mantissa data; inverse transforming the frequency domain data; and in the case M
Patent IL-226291-A (IL)
Title: Binding protein that binds interleukin-13 , pharmaceutical composition comprising same and use thereof for preparation of a medicament
IPC: C12P/
Filed: 2013-05-09
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
[US2008171014A1]
Patent JP-S63267782-A (JP)
Title: Production of triazolopyrimidinamino derivative
Inventor: YAMAJI TEIZO
IPC: C07B61/00
Filed: 1987-04-24
Abstract: PURPOSE:To obtain the titled compound on an industrial scale at a low cost, by reacting a dihalogenotriazole with an amino compound, adding and reacting an alkoxy-substituted acrylic acid derivative to the reaction product and reacting the resultant compound with an amino compound. CONSTITUTION:A 3,5-dihalogeno-1,2,4-triazole of formula I (X is Cl, Br or I) is made to react with an amino compound of formula H2N-R1 (R1 is H, 1-8C alkyl, alkenyl, aralkyl or allyl) in N-methylpyrrolidone at 100-300 deg.C to obtain a monosubstituted triazole derivative of formula II. The derivative is added with an alkoxy-substituted acrylic acid derivative of formula III or IV [R2 is lower alkyl; R3 is H or lower alkyl; R4 is H or -OR5 (R5 is lower alkyl)] and made to react with each other in the presence of a basic catalyst such as alkali metal hydroxide. The triazopyrrolimidine derivative of formula V obtained by the above reaction is reacted with an amino compound of formula VI (R6 and R7 are H, 1-8C alkyl, etc.) to obtain the objective compound of formula VII.
Patent JP-H04339726-A (JP)
Title: Liquid filling device
Inventor: IIDA YOSHIO
IPC: B65B3/12
Filed: 1991-05-01
Abstract: PURPOSE:To prevent air from mixing in a cylindrical main body on which a chuck valve is arranged, from the outside, when a content is filled in a container from the chuck valve. CONSTITUTION:The title liquid filling device is equipped with a rod shaft 3 which is provided in a cylindrical main body 1 so as to be vertically driven; a first chuck valve 74 which is formed on the rod shaft 3 and discharges a fixed quantity of a liquid content N, which is pressure-filled from a filling cylinder, after reserving the fixed quantity of the liquid content N; and a second chuck valve 75 which is provided on the rod shaft 3, and is arranged at a nozzle part to release the liquid content N, which has been discharged by the first chuck valve 74, in a filling container 80. An elastic member 2 which energizes the rod shaft 3 in the direction to close respective chuck valves 74, 75 is provided.
Patent JP-S5623317-A (JP)
Title: Apparatus for pull-out spool of coil rewinder
Inventor: KATSUSHIMA KOUJI
IPC: B65H19/30
Filed: 1979-08-06
Abstract: PURPOSE: To make it possible to pull-out a spool rapidly and precisely without manual operation by arranging a portable truck equipping spool pulling mechanism, etc., inclining mechanism of the truck, and spool pushing mechanism into the storage box to prescribed positions in the titled apparatus.  
     CONSTITUTION: In the apparatus for pulling spool A of coil rewinder 3, truck 1 which can be freely moved on rail 5 against axis line X-X' is equipped and then mechanism 8 which receives spool A on spool cradle 2 by means of pawl member 7 at the advancing position of truck 1 and then inclines the front side of truck 1 at the back position of moving truck 1 to discharge spool A is equipped; mechanism 9 receives spool A and makes it stand and pushing mechanism 10 stores the standing spool successively in storage box 11. A series of said operation can be performed successively by an automatic controlling circuit. 
     COPYRIGHT: (C)1981,JPO&Japio
Patent JP-H08268017-A (JP)
Title: Rear axle support structure of forklift
Inventor: URO AKIRA
IPC: B66F9/075
Filed: 1995-03-30
Abstract: PURPOSE: To enable a resin made spacer to absorb sounds and reduce substantially noises in traveling by inserting the resin made spacer in a gap between the verical surface of a fixed shaft and the vertical surface of a bearing part. CONSTITUTION: Rear wheels are disposed in the rear left and right of a car body 1 and a rear axle 3 supporting the rear wheels is disposed in the intermediate position of the left and right wheels. A fixed shaft 4 is fixed in the longitudinal direction of the rear axle 3 to be supported pivotably by bearing parts 5 fixed to the car body 1. Resin made spacers are respectively one after another inserted in a gap between the vertical surface of the fixed shaft 4 and the vertical surface of the bearing part 5. Also in the assembling operation, the gap is not needed to be so much thinned as in a metal made spacer. One resin made spacer designed to be inserted in the gap sized previously to have the allowance will suffice for the assembling operation which is completed simply in a short time even by an unskilled worker.
Patent JP-H042487-A (JP)
Title: Robot for electric power using device
Inventor: IWASAKI MASARU
IPC: B25J9/00
Filed: 1990-04-18
Abstract: PURPOSE:To make a movable part compact and light-weight and to facilitate control of motion of the movable part, by using a composite energy converting device which jointly owns one part of the magnetic materials used for a motor as the magnetic core of a transformer. CONSTITUTION:The direction of a lamp 1 can be changed by composite energy converting devices 6, 7 and servomotor 27. The power to this lamp 1 is fed to the stationary side coil 24 of a transformer through a transmission cable 25 by a control unit 30 as power and sent to a primary movable part 32 by a movable side coil 23. The power fed to this primary movable part 32 is passed through a separation/mixing device 17 and cable P and fed to a secondary movable part 33. Moreover the magnetic core of the external side of the composite energy converting device consisting of external side 6 and internal side 7 is used as the magnetic core of the transformer, the power fed to the secondary movable part 33 is fed to the transformer from an input terminal 8, the power subjected to voltage converting is taken out of an output terminal 5 and fed to the lamp 1.
Patent JP-S59227258-A (JP)
Title: Preparation of pastry web containing large amount of water
Inventor: KOSONE TAKASHI
IPC: A23L7/109
Filed: 1983-06-07
Abstract: PURPOSE:To prepare an extremely soft and delicious pastry web containing large amount of water, preventing the sticking during the mechanical operation, by heating a raw material of pastry web containing relatively large amount of water at a specific temperature range to effect the conversion of starch to alpha- form and the stabilization of the water, forming the material to a web, and if necessary, slitting or cutting to desired form. CONSTITUTION:A raw material of pastry web composed essentially of wheat flour, preferably glutenous flour, is charged into a stirrer, and kneaded with 40- 80%, especially 50-70% of water containing salt and preferably heated at 50- 70 deg.C. The stirring is continued under heating until the undissolved lump of the flour dissapears, the temperature of the mixture reaches 50-80 deg.C, the conversion of at least a part of the starch to alpha-form takes place, and the contained water takes the stable form. The raw material containing stabilized water is taken out of the stirrer and formed to a web with a pastry roll. The obtained pastry web is cut to a proper form to obtain giaoz, shaomai, SHORONBO, noodle, etc. The pastry shell or noodle prepared from the web contains a large amount of water, and has extremely soft texture and delicious taste.
Patent JP-S5916637-A (JP)
Inventor: CHIYAARUZU BAAKU MATSUKUEBOI
IPC: B30B15/32
Filed: 1983-06-07
Abstract: (57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。
Patent JP-S60246378-A (JP)
Title: Manufacture of substituted oxazoline
Inventor: KENESU ROTSUKU
IPC: C07D263/12
Filed: 1985-05-10
Abstract: This invention relates to a process for preparing 2-oxazolines which comprises cyclodehydrating a hydroxyalkyl- amide in the presence of a stannous salt of a carboxylic acid. The 2-oxazolines have a variety of uses such as pharmaceutical intermediates, pharmaceuticals and as stabilisers for resins.