baber/WOPTO huggingface dataset:
Patent NZ-595749-A (NZ)
Title: Method for treatment of diarrhea-predominant irritable bowel syndrome
Inventor: QUART BARRY
IPC: A61K9/28
Filed: 2007-04-30
Abstract: NZ 595749 Disclosed is the use of an inhibitor as defined herein for the manufacture of a medicament for the treatment of one or more d-IBS (diarrhoea-predominant irritable bowel syndrome) symptoms of diarrhoea, abnormal stool frequency, abnormal stool consistency or presence of urgency, wherein the inhibitor is selected from the group consisting of: an extract from Croton spp. or Calophyllum spp.; latex from Croton spp. or Calophyllum spp.; proanthocyanidin polymer composition from a Croton species or Calophyllum species; and crofelemer, wherein the amount of inhibitor is bioequivalent to crofelemer at a dosage of 50 mg per day to 750 mg per day.
Patent NZ-598610-A (NZ)
Title: High concentration antibody formulations
Inventor: Zhou xiao-hong
IPC: C07K1/02
Filed: 2012-03-07
Abstract: Disclosed is an aqueous solution comprising an anti-C5 antibody at a concentration of 40 mg/mL to 200 mg/mL, wherein the solution comprises: (i) histidine at a concentration of between 20 mM and 50 mM, inclusive of 20 mM and 50 mM; (ii) serine at a concentration of between 30 mM and 100 nM, inclusive of 30 mM and 100 mM; (iii) sorbitol at a concentration of 0.1% to 5% (w/v), inclusive of 0.1% to 5% (w/v); and (iv) at least 1% (w/v) mannitol. Also disclosed is the use of the said solution in treating a patient afflicted with a complement associated disorder.
Patent NZ-602556-A (NZ)
Title: New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
Inventor: PRAT QUINONES MARIA
IPC: A61K31/381
Filed: 2011-05-13
Abstract: Abstract - 602556 Disclosed are cyclohexyl amine derivatives as represented by the general formula (I), or pharmaceutically acceptable salts or N-oxides or solvates or deuterated derivatives thereof, wherein: both X and Y represents a hydrogen atom or, X together with Y form the group -CH=CH-, -CH2-O- or -S-, wherein in the case of -CH2-O- the methylene group is bound to the carbon atom in the amido substituent holding X and the oxygen atom is bound to the carbon atom in the phenyl ring holding Y; R1 and R2 independently represent a hydrogen atom or an alkyl group; R3 represents a C(Ra)(Rb)(Rc) group, a 9-(Ra)-fluoren-9-yl group or a 9-(Ra)-xanthen-9-yl group; and wherein the remaining substituents are as defined herein. Representative compounds include formic acid - trans-4-[(9-{ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} nonyl)(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate, trans-4-[{ 2-[({ [2-chloro-4-({ [(2R)-2-hydroxy-2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino} methyl)-5-methoxyphenyl]amino} carbonyl)oxy]-ethyl} (methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate and trans-4-[{ 2-[({ [2-chloro-4-({ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} methyl)-5-methoxyphenyl]amino} carbonyl)oxy]ethyl} -(methyl) amino]cyclohexyl (2S)-cyclopentyl(hydroxy)2-thienylacetate. Also disclosed is a pharmaceutical composition comprising a compound as defined above in association with a pharmaceutically acceptable diluent or carrier, for the treatment of a pathological condition or disease pulmonary diseases, pre-labor, glaucoma, neurological disorders, cardiac disorders, inflammation and gastrointestinal disorders, asthma and/or chronic obstructive pulmonary disease.
Patent NZ-607658-A (NZ)
Title: Heterocyclyl compounds as Histamine H3 receptor ligands
Inventor: NIROGI RAMAKRISHNA
IPC: A61P25/00
Filed: 2012-12-24
Abstract: Disclosed is a substituted fused heterocycle of formula (I) where the substituents are as disclosed in the specification. 
Examples of a compounds of formula (I) are: 1-[2-(1-Ethoxymethyl-piperidin-4-yloxy)-6,7 -dihydro-4-H-thiazolo[5,4-c]pyridin-5-yl]-propan-1-one; 1-{2-[1-(2,2,2-Trifluoro-ethyl)-piperidin-4-yloxy]-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl}-propan-1-one; 1-[2-(1-Cyclobutyl-azetidin-3-yloxy)-6,7-dihydro-4-H-thiazolo[5,4-c]pyridin-5-yl]-propan-1-one; 1-[2-(1-Cyclobutyl-pyrrolidin-3-yloxy)-4,6-dihydro-pyrrolo[4,3-d]thiazol-5-yl]-propan-1-one; and 1-[2-(1-Cyclobutyl-azepan-4-yloxy)-4,6-dihydro-pyrrolo[4,3-d]thiazol-5-yl]-propan-1-one. 
Also disclosed are pharmaceutical compositions comprising a compound of formula (I); the process for preparing a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament. The medicament is useful in the treatment of cognitive disorders, sleep disorders, obesity and pain.
Patent NZ-620334-A (NZ)
Title: Dual chamber device
Inventor: HAUGHEY JAMES QUINTON STEWART
IPC: A61M5/315
Filed: 2012-08-06
Abstract: A dual chamber syringe comprising a first barrel defining a first chamber (12) for holding a first composition, the first chamber having at least one side wall and a distal end wall defining a dispensing nozzle (22). A second barrel defining a second chamber (14) for holding a second composition, the second chamber having at least one side wall (14) and a distal end wall, an annular seal at the distal end of the second barrel, and the at least one side wall of the second chamber defining at least one orifice proximal to the seal; and a plunger operable to drive the second barrel into the first chamber to displace the first composition out of the first chamber through the nozzle, and to bring the annular seal of the second barrel into contact with the distal end wall of the first chamber, thereby to deform the seal and permit fluid communication between each orifice in the second barrel and each flow channel, wherein the plunger is subsequently moveable into the second chamber to displace the second composition out of the second chamber through each orifice and flow channel to the nozzle.
Patent NZ-626397-A (NZ)
Title: Method and apparatus for reducing the thickness of a precoat layer of a disc filter
Inventor: HAMMARBERG TOMMI
IPC: B08B1/02
Filed: 2013-02-05
Abstract: A method for removing scale or precoat from a plurality of disc or drum filters is described. The rotating filters (12) are aligned in series along a shaft (10) and have scrapers (20) on either side. The left blade of one disc shares a chute or channel (38) with the right blade of an adjacent disc. The caked on chemical sludge, precoat or scale (57) is removed such that the chute is only being filled from one side at a time. This is done by sliding the shaft (See Drawing) or actuating the scrapers toward the discs, i.e. the chutes are filled non-simultaneously.
Patent NZ-626700-A (NZ)
Title: Application licensing using sync providers
Inventor: LI KARVELL
IPC: G06F21/10
Filed: 2013-01-21
Abstract: Disclosed is a system for licensing an application (220) using sync providers. The system comprises a client sync provider configured to receive a provisioning request from a commerce partner via a commerce partner sync provider. The client sync provider sends a system call for requesting a license for an application (220) to a licensing service, and periodically determines and updates a state of the license. The licensing service is configured to return the license for the application (220) to a client computing device. The licensing service receives information relating to the state of the license from the client sync provider and adjusts conditions of the license according to the state of the license.
Patent NZ-627796-A (NZ)
Title: Influenza virus vaccines and uses thereof
Inventor: GARCIA-SASTRE ADOLFO
IPC: A61K39/145
Filed: 2013-12-17
Abstract: Disclosed is a chimeric influenza virus hemagglutinin (HA) polypeptide comprising the stem domain of the HA from influenza virus A/California/4/2009 (H1N1) and the globular head domain of the HA from influenza virus A/Vietnam/1203/2004 (H5).
Patent NZ-629494-A (NZ)
Title: Glycosaminoglycan and synthetic polymer materials for blood-contacting applications
Inventor: JAMES SUSAN P
IPC: A61L31/14
Filed: 2013-03-11
Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
Patent NZ-630347-A (NZ)
Title: Use of amphoteric surfactants for the prevention and treatment of pathogenic vaginal biofilms in vaginal infections
Inventor: ABELS CHRISTOPH
IPC: A61P15/02
Filed: 2013-03-19
Abstract: The discosure relates to amphotheric surfactants for use in preventing and/or treating vaginal infections, in particular for preventing and treating pathogenic vaginal biofilms in vaginal infections, as well as to pharmaceutical compositions containing the amphoteric surfactants as active ingredients. Preferred amphoteric surfactants include: cocoamidopropyl hydroxysultaine, disodium cocamphodiacetate, sodium cocoamphopropionate and sodium lauroamphoacetate. In particular anti-microbial action against Gardnerella vaginalis is shown.
Patent NZ-631247-A (NZ)
Title: Carton with insert
Inventor: MONCRIEF FRANK N
IPC: B65D71/28
Filed: 2013-04-26
Abstract: A box suitable for carrying bottles with an insert in the top panel and edge flaps is described. The insert provides extra layers of cardboard or other material to strengthen the handle openings on the sides of the box. The insert comprises a central panel (107), reinforcing end panels (111), and end panel flaps (127, 129) that are folded back over the end panel. The end panel and end panel flaps include handle openings and, along with similar openings in the top and side edge flaps (49, 43, 39) of the box, provide multiple reinforcing layers for the handles.
Patent NZ-705040-A (NZ)
Title: Fused pyrimidines as inhibitors of p97 complex
Inventor: ZHOU HAN-JIE
IPC: C07D513/04
Filed: 2013-07-19
Abstract: Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.
Patent NZ-710735-A (NZ)
Title: Boat sail comprising shape memory material elements, apparatus and method for its operation
Inventor: DOGLIOTTI ANDREA
IPC: B63H9/08
Filed: 2014-02-13
Abstract: The invention relates to a sail (R, G; 60; 70; 80; 90; 100) for sailboats, which generally addresses the need to control the operation of a boat sail by the adjustment of a sail camber. Said sail (R, G; 60; 70; 80; 90; 100) comprises portions (1’; F61-F65; F71-F76; F81-F84; F91-F95; F101-F110) wherein shape memory elements in the form of filiform members (2) made of a shape memory alloy are incorporated, the surface area resulting from the sum of the surface areas of said portions being comprised between 0,01% and 50% of the surface area of the whole sail. The shape memory elements are provided to at least enable adjustment of the sail camber. The invention also relates to a control apparatus allowing to control operation of the sail and to a method for controlling operation of a sailboat sail.
Patent NZ-712630-A (NZ)
Title: Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
Inventor: BAR-OR DAVID
IPC: A01N25/00
Filed: 2014-03-17
Abstract: The invention provides compositions comprising DA-DKP that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
Patent NZ-721522-A (NZ)
Title: Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
Inventor: MAECKER HEATHER
IPC: C07K16/28
Filed: 2013-05-30
Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist, oxaliplatin, leucovorin and 5-FU, and optionally a VEGF antagonist, and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired, such as increasing tumor immunogenicity for the treatment of cancer.
Patent NZ-725884-A (NZ)
Title: Apparatus for Mounting to a Post
Inventor: BRADLEY TAYLOR
IPC: E04H17/24
Filed: 2016-11-02
Abstract: An apparatus (10, 10’) is disclosed for mounting to a post (100, 200, 300, 300’, 400). The post is of a type that comprises an elongate flange (102, 202, 302, 402) that has at least one aperture (104, 204, 304, 404) through the flange. The post also comprises at least one passage (106, 206, 306, 406) that is spaced from the aperture. The passage extends into the flange from a distal edge (110, 210, 310, 410) of the flange. The apparatus (10, 10’) comprises a first leg (12, 212) and a second leg (14, 214). The legs are connected at their proximal ends by a connector (16, 216). The connector is able to be located in the passage. Each leg comprises a formation (18, 20; 218, 220) at its distal end that is able to be located at the aperture to mount the apparatus to the post. The first leg extends at a first angle (A) with respect to the connector and the second leg extends at a second angle (B) with respect to the connector. The second angle is less than the first angle.
Patent NZ-730404-A (NZ)
Title: Compositions and methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
Inventor: QUERBES WILLIAM
IPC: A61K31/713
Filed: 2015-10-09
Abstract: The invention relates to RNAi agents, e.g. double-stranded RNAi agents, targeting the HAO1 gene, and methods of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1. Described herein are double-stranded RNAi agents which inhibit the expression of a HA01 gene in a cell, such as a cell within a subject, e.g., a mammal, such as a human having a HAO1 associated disorder, and uses of such double-stranded RNAi agents. In certain aspects of the invention, substantially all of the nucleotides of an iRNA of the invention are modified.
Patent NZ-730521-A (NZ)
Title: Injectable buprenorphine formulation
Inventor: TIBERG FREDRIK
IPC: A61K9/08
Filed: 2015-10-27
Abstract: The present invention provides an injectable liquid formulation with controlled release comprising: • a) a lipid controlled-release matrix comprising at least 50% triacyl lipids; • b) at least one oxygen containing organic solvent; • c) at least 16% by weight of at least one active agent selected from buprenorphine and salts thereof, calculated as buprenorphine free base. The invention also provides a method for the treatment of pain, for opioid maintenance therapy or for the treatment of opioid dependence by detoxification and/or maintenance or for the treatment or prophylaxis of the symptoms of opioid withdrawal and/or cocaine withdrawal by injecting such a liquid composition.
Patent NZ-732182-A (NZ)
Title: Targeted rna editing
Inventor: PLATENBURG GERARDUS JOHANNES
IPC: C12N15/113
Filed: 2015-12-17
Abstract: RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of forming an intramolecular stem-loop structure, and capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.
Patent NZ-734551-A (NZ)
Title: A control algorithm for an electronic dimming ballast of a uv lamp
Inventor: REINER FIETZEK
IPC: G05F1/10
Filed: 2017-08-11
Abstract: The present invention relates to a control algorithm for operating a fluid disinfecting system by means of UV radiation, wherein the UV radiation is generated by at least one UV lamp comprising a pair of heating cathodes having a discharge voltage (UD), said UV lamp is operated by an electronic ballast unit, which is equipped with the control algorithm, which allows to adjust the UV power of the UV lamp by pulse-width-modulation, to reduce UV power said control algorithm includes the following steps: • Decreasing the current to a level (Ikmin); • Increasing the voltage amplitude (U) above the discharge voltage (UD) until a desired UV power level is reached; • With increasing voltage amplitude (U) decreasing the pulse width (PW), until PWmin is reached; • Wherein the decrease in current and the increase in voltage are carried out in such a way, that an ineffective current-voltage-ratio is generated, whereas the too high current is used for cathode heating.
Patent NZ-743615-A (NZ)
Title: Environmental monitoring systems, methods and media
Inventor: FARAHMAND TOURAJ
IPC: G01F9/00
Filed: 2016-11-24
Abstract: A system for monitoring a physical environmental property having non-stationary heteroscedastic noise is disclosed. A processor receives physical environmental measurement data, and constructs a combined input and output noise levels matrix containing output noise terms associated with the physical environmental property and input noise terms associated with the at least one independent variable. Using the combined input and output noise levels matrix, the processor constructs a main Gaussian Processes (GP) model for the physical environmental property and its non-stationary heteroscedastic noise. The processor generates and co-operates with the output device to perceptibly output a predictive probabilistic representation of the environmental property, using the main GP model. The predictive probabilistic representation includes a respective range of possible values of the physical environmental property for each respective value of the independent variable(s), the range reflecting both the input noise terms and the output noise terms.
Patent NZ-758770-A (NZ)
Title: Method for preparing intermediate of 4-methoxypyrrole derivative
Inventor: LEE SEUNG CHUL
IPC: C07D207/36
Filed: 2018-06-21
Abstract: The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.
Patent NZ-758874-A (NZ)
Title: Refrigerator
Inventor: XIA ENPIN
IPC: E05D3/18
Filed: 2018-06-29
Abstract: A refrigerator (100), comprising a refrigerator body (1), a door body (2), and a hinge body (11). The door body (2) is provided with a guide block (21). The hinge body (11) is provided with a locating shaft (12) and a guide shaft (13). The guide block (21) is provided with a locating groove (25) and a guide groove (26). The hinge body (11) comprises a first plate body (17) and a second plate body (18) arranged at an interval in the height direction, so as to share the gravity and friction of the door body (2), thereby reducing wear and prolonging the service life of the door body (2).
Patent NZ-762473-A (NZ)
Title: Bioactive honey production environment and method
Inventor: MUNDAY DAVID
IPC: A23K50/90
Filed: 2018-08-14
Abstract: An artificially-created honey-yielding environment is established, comprising a hive and an associated flora cell, within which first and second plant populations cohabit. Within the cell, honey-producing insects from the hive are permitted to forage. One of the populations has been artificially introduced. The other may be indigenous to the cell. The first plant population serves as a primary source of nectar which yields bioactive honey and the second serves as a source of a nutrient, such as protein, which is not abundantly available from the first species at a nutritionally adequate level for sustaining the metabolism and energy of the foraging honey-producing insects for returning to the hive. The first flora population may be a Leptospermum species. An example of the second is Corymbia maculata. The arrangement helps maximise the bioactive honey produced.
Patent NZ-765006-A (NZ)
Title: Ex vivo organ care system
Inventor: HASSANEIN WALEED
IPC: A01N1/02
Filed: 2015-06-02
Abstract: The invention generally relates to systems, apparatuses, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiments of the disclosed subject matter are possible. Embodiments of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiments, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near a physiological temperature, pressure, and flow rate. The technique that can extend the time during which an organ such as a liver can be preserved in a healthy state ex-vivo and enable assessment capabilities.
Patent PT-101472-A (PT)
Title: Device for connecting prefabricated elements for producing sound-insulation barriers
IPC: E04B1/48
Filed: 1994-03-04
Abstract: A process for constructing, by means of prefabricated concrete elements, sound-insulation barriers A and B which are formed by means of the longitudinal juxtaposition of the elements 1 which fit together in a "male/female" manner 3. The system for connecting the element 1 to the foundation E and F, 4 involves a specific device which simultaneously allows the connection and the support of the element. The foundation is formed by a prefabricated concrete slab 4, of parallelepipedal geometry, with a cavity in the upper face 8, which allows the fitting-together of located projections 5 which exist on the elements 1. The "barrier/foundation" connection is completed with the insertion of two steel rods 7 which pass through the element 1 and the foundation 4. Subsequently, the cavity 4 is sealed with concrete in order to guarantee the solidity of the assembly and the protection of the rods. <IMAGE>
Patent PT-101989-A (PT)
Title: System for pumping seawater using tidal power
IPC: F03B13/26
Filed: 1997-04-07
Abstract: The system comprises the installation of pillars 1 on the seabed that are connected by girders surrounding floating platforms 2, with tie-rods 3 in the mountings, which, by means of the force exerted with the rising of the tides over the platforms and the weight of the latter upon descent, will move, by means of chains 4, the shafts 5 provided with a pinion 6 and four racks 7, with triple the diameter of the pinion, forcing the pistons 8 to rise on the one hand and to fall on the other in the tanks 9, with a diameter of 3 mm and a height of 10 mm, generating the entry of the water into some and its exit from others. The water drawn out will, under the pressure of the drums, be conveyed by the collectors 10 to the dam. Given a difference in level of 2 m between low tide and high tide, we will obtain (3.14159 x 6 x 64 x 4 = 4825.48224 m3/day) Purposes : production of electrical energy, aquaria, swimming pools, water parks. Advantages : non-polluting, ecological, no expropriations, constancy of efficiency and economy in terms of installation and maintenance. <IMAGE>