Patent SG-11201804890T-A (SG)
Title: Bipyrazolyl derivatives useful for the treatment of autoimmune diseases
Inventor: BOSANAC TODD
IPC: A61P37/06
Filed: 2016-12-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 1111101110101101100111 01111101111111011 11 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/106429 A2 22 June 2017(22.06.2017) WIPO I PCT (51) International Patent Classification: Not classified Legal, Boehringer Ingelheim USA Corp., 900 Ridgebury Rd., P.O. Box 368, Ridgefield, Connecticut 06877-0368 (21) International Application Number: (US). FRYER, Ryan Michael [US/US]; c/o VP, IP Legal, PCT/US2016/066799 Boehringer Ingelheim USA Corp., 900 Ridgebury Rd., (22) International Filing Date: P.O. Box 368, Ridgefield, Connecticut 06877-0368 (US). 15 December 2016 (15.12.2016) LARSON, Eric Thomas [US/US]; c/o VP, IP Legal, Boehringer Ingelheim USA Corp., 900 Ridgebury Rd., (25) Filing Language: English P.O. Box 368, Ridgefield, Connecticut 06877-0368 (US). (26) Publication Language: English MAO, Wang [CN/US]; c/o VP, IP Legal, Boehringer In- gelheim USA Corp., 900 Ridgebury Rd., P.O. Box 368, (30) Priority Data: Ridgefield, Connecticut 06877-0368 (US). MCKIBBEN, 62/268,278 16 December 2015 (16.12.2015) US Bryan Patrick [US/US]; c/o VP, IP Legal, Boehringer In- 62/431,008 7 December 2016 (07.12.2016) US gelheim USA Corp., 900 Ridgebury Rd., P.O. Box 368, (71) Applicant: BOEHRINGER INGELHEIM INTERNA- Ridgefield, Connecticut 06877-0368 (US). SHEN, Yue TIONAL GMBH [DE/DE]; Boehringer Ingelheim GmbH, [CN/US]; c/o VP, IP Legal, Boehringer Ingelheim USA Corporate Patents, Binger Strasse 173, 55216 Ingelheim Corp., 900 Ridgebury Rd., P.O. Box 368, Ridgefield, Con- am Rhein (DE). necticut 06877-0368 (US). SOLEYMANZADEH, Fariba [CA/US]; c/o VP, IP Legal, Boehringer Ingelheim USA (72) Inventors; and Corp., 900 Ridgebury Rd., P.O. Box 368, Ridgefield, Con- (71) Applicants (for US only): BOSANAC, Todd [US/US]; necticut 06877-0368 (US). TSCHANTZ, Matt Aaron c/o VP, IP Legal, Boehringer Ingelheim USA Corp., 900 [US/US]; c/o VP, IP Legal, Boehringer Ingelheim USA Ridgebury Rd., P.O. Box 368, Ridgefield, Connecticut Corp., 900 Ridgebury Rd., P.O. Box 368, Ridgefield, Con- = 06877-0368 (US). BENTZIEN, Joerg [DE/US]; c/o VP, necticut 06877-0368 (US). = IP Legal, Boehringer Ingelheim USA Corp., 900 Ridge- — bury Rd., P.O. Box 368, Ridgefield, Connecticut 06877- _ 0368 (US). BURKE, Michael Jason [US/US]; c/o VP, IP = [Continued on next page] (54) Title: = 10 = > ›-. . _ ,0 CO 0 10 0 > 8 - co = I .E - g z 6 g = a E 4 HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS p 0.06 erg. Control , (57) : The present invention encompasses com- pounds of the formula (I) wherein the groups R I , Cy and Y are defined herein, which are suitable for the treatment of dis - eases related to BTK, and processes for making these com- pounds, pharmaceutical preparations containing these com- * pounds, and their methods of use. 2 2 — - .,- - 0.) 2 c\".1 = C6 — = = 0 0 = Example Cmpd. B Cmpd. A Cmpd. C Ex. 12 Ex. 22 Doee 10 30 10 30 10 30 10 30 10 30 = FIG. 1 ei H 2 N Cy 01 ei \ 71- HN , N N / 0 Ri Y 1-1 (1) IN 1-1 0 ei O WO 2017/106429 A2111110H3101010ig11013010111001111 1111EE1101 IIE (74) (81) Agents: MORRIS, Michael P. et al.; Boehringer Ingel- heim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877-0368 (US). Designated States (unless otherwise indicated, for every GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, Declarations under Rule 4.17: GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, — as to applicant's entitlement to apply for and be granted KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, a patent (Rule 4.17(0) NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, Published: (84) QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, without international search report and to be republished upon receipt of that report (Rule 48.2(g))