baber/WOPTO huggingface dataset:
Patent NZ-210677-A (NZ)
Title: Process for the production of alkylene glycols
Inventor: GRIGGS C G
IPC: C07C29/00
Filed: 1984-12-20
Abstract: Higher alkylene glycols, having more than three carbon atoms, are prepared by reacting a secondary alcohol with formaldehyde in the presence of an organic peroxide of formula R-O-O-R<1> in which R and R<1> are independently alky or aralkyl groups containing 3 to 12 carbon atoms. By using secondary alcohols, oxidation of the alcohol reactant is reduced. The reaction is preferably carried out under anhydrous conditions using a polymeric source of formaldehyde.
Patent NZ-216657-A (NZ)
Title: N-buten-3-yl-azaheterocyclic carboxylic acid compounds and pharmaceutical compositions
Inventor: GRONVALD F C
IPC: A61K31/395
Filed: 1986-06-25
Abstract: 1-Aminobut-3-en derivatives having optionally substituted furanyl, thienyl, pyridyl and/or pyrrolyl in the 4-position and 3-carboxypiperidin-1-yl, 3-carboxytetrahydropyrid-1-yl or 3 carboxymethylpyrrolidin-1-yl in the 1-position potentiate GABA-ergic neurotransmission.
Patent NZ-217185-A (NZ)
Title: Alleviating cytopathic effects of htlv-iii virus on cells; pharmaceutical composition
Inventor: HIROAKI MITSUYA
IPC: C07D473/16
Filed: 1986-08-13
Abstract: The present invention relates to a method of alleviating the cytopathic effects of HTLV-III virus on cells which comprises contacting the virus with an effective amount of a purine base, which is 2 min ,3 min -dideoxyinosine, 2 min ,3 min -dideoxyguanosine, 2 min ,3 min -dideoxyadenosine or phosphates thereof.
Patent NZ-217243-A (NZ)
Title: Semicarbazones and thiosemicarbazones and herbicidal compositions
Inventor: ANDERSON R J
IPC: C07D213/82
Filed: 1986-08-18
Abstract: The invention relates to novel compounds of formula (A) <CHEM> wherein R<2> is the group -C(=NR<1><0>)-SR<9> or -C(=X)-NHR<1><0>, and R, R<3>, R<4>, R<9> and R<1><0> are as stated in the specification, the synthesis thereof, the use of said compounds for the control of weeds and compositions for weed control comprising such compounds.
Patent NZ-218583-A (NZ)
Title: Continuous process for synthesis of oxalic acid diesters
Inventor: CRANDELL J W
IPC: C07C69/36
Filed: 1986-12-10
Abstract: A process is provided for the utilization of dialkyl carbonates formed as by-products in a continuous process for the synthesis of oxalic acid esters from nitrous acid esters and carbon monoxide and wherein the esters are subsequently used as intermediates in the production of commercially useful products, such as ethylene glycol. The process comprises contacting a mixture containing the by-product comprised of a dialkyl carbonate with an aqueous solution of a metal carbonate under hydrolyzing conditions whereby the dialkyl carbonate is converted to the corresponding alkanol and the metal carbonate is converted to metal bicarbonate. Upon distillation of the alkanol from the mixture the bicarbonate is converted back to the metal carbonate which can then be recycled from the bottoms to the hydrolyzing zone for use in further hydrolysis of by-product. The alkanol is recycled for use in the continuous process.
Patent NZ-220948-A (NZ)
Title: Nickel-chelate resins, their preparation and use in chromatography for purifying proteins; and n-(omega-amino-1-carboxyalkyl)-iminodiacetic acid derivatives used to prepare the resins
Inventor: DOBELI HEINZ
IPC: B01J20/32
Filed: 1987-07-03
Abstract: Metal chelate resins whose complexed nitrilotriacetic acid residues are bound to a carrier matrix via a spacer and which are suitable for metal chelate chromatography of proteins, especially those which contain neighboring histidines.
Patent NZ-223162-A (NZ)
Title: A printing plate precursor comprising a substrate, a radiation sensitive composition and a barrier layer
Inventor: WADE J R
IPC: G03F7/09
Filed: 1988-01-12
Abstract: A printing plate precursor comprises a substrate coated with a radiation sensitive composition overcoated with a barrier layer to prevent oxygen inhibiting photopolymerisation of the composition. The barrier layer comprises a polymer and an amphoteric compound.
Patent NZ-228814-A (NZ)
Title: Polycarbonate panel comprising a polycarbonate sheet together with a layer of polycarbonate containing a bis-benzotriazole
Inventor: PAUL WINFRIED G
IPC: C08L69/00
Filed: 1989-04-19
Abstract: The present invention is related to a stain resistant polycarbonate panel which preferably comprises co-extruded polycarbonate sheet and an adherent layer based on linear polycarbonate resin which contains an additive conforming to  <IMAGE>  wherein R1 and R2 independent of each other are a hydrogen or a halogen atom, a C1-C12 alkoxy, C7-C18 arylalkoxy or a C1-C10 alkyl, cycloalkyl, arylalkyl or an aryl radical and R3 and R4 independent of each other are a hydrogen atom, a C1-C10 alkyl, cycloalkyl, arylalkyl or an aryl radical, n is an integer of 0-4 and m is an integer of 1 to 3, -Bridge- is either <IMAGE>   where p is 0-3, q is 1-10, Y denotes any of  <IMAGE> +TR <IMAGE>  and R3 and R4 independently denote a hydrogen atom a C1-C10 alkyl, cycloalkyl, arylalkyl or an aryl radical characterized in that said adherent layer is about 5 to 100 microns in thickness and in that only one of its surfaces is bonded.
Patent NZ-230327-A (NZ)
Title: Synergistic combination of t-pa and activated protein c (apc)
Inventor: BERGER HENRY
IPC: A61K38/46
Filed: 1989-08-16
Abstract: The use of t-PA and activated protein C in preventing reocclusion of a blood vessel in a mammal.
Patent NZ-240175-A (NZ)
Title: Disposable nappy pants; elastic members converge towards transverse edges of the pants
Inventor: PFEIFER ROLAND
IPC: A61F13/494
Filed: 1991-10-09
Abstract: Disposable shaped nappy comprising a water-impermeable outer sheet (2), defining a narrower crutch area (27) between the two wider ends or waistband areas (28, 29), an absorbent pad (22), securing elements (24) for attaching the nappy, and elastic elements (4) tensionally secured to the water-impermeable sheet (2) on either side of the absorbent pad (22), substantially on all the length of the water-impermeable sheet. The elastic means have a higher tension in the crutch region (27) than in the end areas (28, 29), and have, in the latter (28, 29), sections (4c) converging in the direction of the transversal edges of the water-impermeable sheet, so that the elastic elements (4) form a virtually closed elastic barrier around the absorbent pad (22), thereby providing a water-impermeable sheet which is longitudinally elastic in the crutch area and transversally elastic in the ends.
Patent NZ-241785-A (NZ)
Title: Azabicyclo ring-containing imidazolidine derivatives, preparation and
Inventor: VARASI MARIO
IPC: A61K31/4166
Filed: 1992-02-28
Abstract: Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (I) <CHEM>  in which inter alia R3 represents a group  a) <CHEM>  or b) <CHEM>  wherein n is an integer of 1 or 2 and R8 is hydrogen, C1-C6 alkyl unsubstituted or substituted by phenyl, C2-C4 alkenyl, C2-C4 alkynyl, formyl or C2-C6 alkanoyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.
Patent NZ-243065-A (NZ)
Title: Piperidine derivatives and pharmaceutical compositions
Inventor: PERREGAARD JENS KRISTIAN
IPC: C07D491/107
Filed: 1992-06-08
Abstract: Piperidine compounds having the general general Formula Iwherein R<sup>1</sup> isa group having the general Formula II :wherein X is CHR<sup>10</sup>, O, S, SO, SO<sub>2</sub> or NR<sup>10</sup>, R<sup>10</sup> being hydrogen, alkyl or alkenyl, an amino group, sulfonyl, optionally substituted phenyl or a hetero aromatic group; Y is CH, CH<sub>2</sub>, NH, C=O or C=S; R<sup>a</sup> ― R<sup>d</sup> are substituents; U is CH<sub>2</sub>, O or S; Q<sup>1</sup> is a bond , alkylene or alkenylen and Q<sup>2</sup> alkylene having at least two C-atoms or alkenyleneR<sup>2</sup> and R<sup>3</sup> are hydrogen, or alkyl or they may together form an ethylene or propylene bridge; R<sup>4</sup> to R<sup>7</sup> are substituents; andZ<sup>1</sup> is substituent, Z<sup>2</sup> is hydrogen and Z<sup>3</sup> is (CH<sub>2</sub>)<sub>n</sub> wherein n is 0; show potent sigma receptor activity. Furthermore they show effect in animal models indicative of anxiolytic properties. Accordingly they are useful as medicines for the treatment of anxiety, psychosis, epilepsy, convulsion, movement disorders, motor disturbances, amnesia, cerebrovascular diseases, senile dementia of the Alzheimer type or Parkinson's disease.
Patent NZ-247776-A (NZ)
Title: Stackable tray of corrugated cardboard with one piece bottom with walls and interchangeable reinforcing band pieces adhered to walls
Inventor: MARCH VILA FATIMA
IPC: B65D5/00
Filed: 1993-06-03
Abstract: The tray comprises a base part, in the shape of a small cask, forming the bottom panel (1) of the tray with an upwardly extending peripheral flange (2) to which is attached one or more parts (3) that form the four sidewalls of the tray. Additional elements (4) may be added to the sidewalls to enhance structural stiffners. According to a further aspect of the invention, the plane of the bottom panel lies below the lower most edge (3a) of the sidewalls, providing a stepped portion which may be received into the open upper end of an underlying similar tray to provide a positive stacking means, the upper edge of the sidewalls (3c) of the underlying tray supporting the lower edge (3a) of the sidewalls of the overlying tray. The bottom panel and sidewalls may be formed from differing densities of cardboard. <IMAGE>
Patent NZ-250955-A (NZ)
Title: Triazolopyrimidine derivatives and plant fungicides
Inventor: PEES KLAUS-JURGEN
IPC: A01N43/90
Filed: 1994-02-23
Abstract: This invention relates to certain triazolopyrimidine derivatives of the general formula <CHEM> in which R<1> represents an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl, cycloalkyl, bicycloalkyl or heterocyclyl group; R<2> represents a hydrogen atom or an alkyl group; or R<1> and R<2> together with the interjacent nitrogen atom represent an optionally substituted cycloalkyl or heterocyclic ring; R<3> represents an optionally substituted cycloalkyl or heterocyclyl group; and R<4> represents a hydrogen or halogen atom or a group -NR<5>R<6> where R<5> represents a hydrogen atom or an amino, alkyl, cycloalkyl or bicycloalkyl group and R<6> represents a hydrogen atom or an alkyl group; processes for their preparation; compositions containing such compounds and their use as fungicides.
Patent NZ-281522-A (NZ)
Title: Testing for asthma susceptability comprising inhalation of powder which can change airway size and measuring change in airflow
Inventor: ANDERSON SANDRA DOREEN
IPC: A61K31/70
Filed: 1995-02-23
Abstract: PCT No. PCT/AU95/00086 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Feb. 23, 1995 PCT Pub. No. WO95/22993 PCT Pub. Date Aug. 31, 1995A method as described for testing the susceptibility of a person to asthma. The person inhales an effective amount of sodium chloride, mannitol or another substance capable of altering the osmolarity of airway surface liquid in the subject. The substance is in the form of a dispersible dry powder containing an effective proportion of particles of a respirable size. The subject is then measured to detect airway narrowing which is indicative of a propensity for asthma. The same technique of dry powder inhalation can be used to test for the susceptibility of a person to rhinitus, to induce sputum and promote mucociliary clearance.
Patent NZ-324867-A (NZ)
Title: A method for insect-resist treatment of carpet and textiles
Inventor: INGHAM PETER EDWARD
IPC: D06M13/265
Filed: 1996-12-20
Abstract: Disclosed is a  method of treating carpet and other textile products comprising animal fibres or a mix of synthetic fibres and animal fibres. The method includes applying a formulation to carpet or other textile products.  The formulation comprises compounds effective against the larvae of a range of Coleopteran species and a chemical which is effective against the larvae of a range of Lepidopteran species.  The fluorosurfactant compound can offer only partial control of the larvae of a range of Lepidopteran species.  The formulation can be added to the carpet, yarn, loose fibre or other textiles during raw-wool scouring, dyeing, tapescouring, chemsetting or continuous carpet treatment.
Patent NZ-326495-A (NZ)
Title: A lock cylinder with plate or wafer tumblers
Inventor: BABER MURRAY JAMES
IPC: E05B29/04
Filed: 1997-01-31
Abstract: This lock cylinder is of a plate or wafer tumbler type. The cylinder (10) has a plurality of locking wafers (19) and a key slot (14).  The locking wafer (19) includes a pair of legs (21) which define therebetween an open ended key receiving slot in the wafer.  This open-ended key receiving slot aligns with a key receiving channel (15), being an extension of the key slot (14), which extends into or through the wall of the body (11) of the cylinder.  As a result a key of greater depth than normally required to operate the wafer lock can be accommodated in the aligned key slots and key receiving channel.  This permits common keying between wafer and pin tumbler locks to be achieved.
Patent NZ-331956-A (NZ)
Title: Pressurized gas cushions to reduce surface drag on a vessel hull
Inventor: HARLEY HOWARD D
IPC: B63B1/20
Filed: 1997-03-06
Abstract: A surface effect hull particularly suitable for use with a catamaran vessel. The twin hulls each comprise a V-shaped portion and a recess portion that receives pressurized gas therein. The V-shaped bow portion create dynamic lift and the pressurized air portion creates an air cushion for reduction of drag.
Patent NZ-333375-A (NZ)
Title: A process for the alkylation of alkyl- or benzylcyanogen derivatives in the presence of trialkylamines or -phosphines
Inventor: KORB GERHARD
IPC: C07C255/34
Filed: 1998-12-15
Abstract: A process for the preparation of the compounds of the formula 1 wherein: R1 is (C1-C20)-alkyl or mono, di or trisubstituted (C1-C20)-alkyl, R2 is (C1-C20)-alkyl, mono, di or trisubstituted (C1-C20)-alkyl, phenyl or mono, di or trisubstituted phenyl and R3 is phenyl or mono, di or trisubstituted phenyl.  The process involves reacting benzylcyanogen derivatives of the formula II wherein: R3 is phenyl or mono, di or trisubstituted phenyl, R4 is H or (C1-C20)-alkyl, mono, di or trisubstituted (C1-C20)-alkyl, phenyl or mono, di or trisubstituted phenyl with compounds of the formula V and/or formula VI wherein: R7, R8, R9, R10, R11, and R12 can be the same or different and are selected from (C1-C30)-alkyl or phenyl.  The products produced by this process can be used for the preparation of antiallergically effective medicaments such as 4-[4[-4-(hydroxydiphenyl)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethylphenylacetic acid.
Patent NZ-334067-A (NZ)
Title: 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene, inhibitors of HPPD, method of conferring resistance to HPPD inhibitors and a method for detecting herbicide resistant HPPD genes
Inventor: STURNER STEPHEN
IPC: C12N15/09
Filed: 1997-07-25
Abstract: A method for the identification of herbicide resistant 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors comprising the steps of: (a) incubating a cell transformed with and expressing the nucleic acid which includes a sequence encoding HPPD proteins expressed in plants, the presence of a test compound to form a test culture, and in the absence of a test compound to form a control culture; (b) monitoring the level of homogentistic acid or oxidation products thereof, in the test culture and control; and (c) identifying as a compound that inhibits HPPD any compound that reduces the level of homogentistic acid or oxidation products thereof, in the test culture relative to the control culture.  A variant HPPD protein is produced from Arabidopsis thaliana for use in the test culture is described. The amino acid encoding Arabidopsis thaliana HPPD being: MGHQNAAVSENQNHDDGAASSPGFKLVGFSKFV RKNPKSDKFKVKRFHHIEFWCGDATNVARRFSW GLGMRFSAKSDLSTGNMVHASYLLTSGD LRFLFT APYSPSLSAGEIKPTTASIPSFDHGSCRSFFSSHGL GVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEA VTIAEVKLYGDVVLRYVSYKAEDTEKSEFLPGFE RVEDASSFPLDYGIRRLDHAVGNVPELGPALTYV AGFTGFHQFAEFTADDVGTAESGLNSAVLASNDE MVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHL ALMSEDIFRTLREMRKRSSIGGFDFMPS PPPTYYQ NLKKRVGDVLSDDQIKECEELGILVDRDDQGTLL QIFTKPLGDDRRTIFIEIIQRVGCMMKDEEGKAYQ SGGCGGFGKGNFSELFKSIEEYEKTLEAKQLVG
Patent NZ-337346-A (NZ)
Title: Two-part mold comprising a crosslinked polymer formed by exposure to UV light
Inventor: HERBRECHTSMEIER PETER
IPC: B29C71/00
Filed: 1998-03-23
Abstract: Efficient and consistent processes for manufacturing moldings, especially ophthalmic lenses such as contact lenses. The processes comprise a series of improvements, including improvements in the areas of conditions for dispensing liquid prepolymer into lens molds, male and female mold mating, reusable molds, mold cleaning, lens separation from molds (demolding), lens handling, and in-line inspection. Cyclic series of processing steps are also disclosed. Additionally, an improved molding tool is disclosed, with the molding tool including a male mold housing and a female mold housing, each of which has disposed therein a plurality of mold halves.
Patent NZ-337417-A (NZ)
Title: An ultrasound receiver assembly for use with conventional presentation boards
Inventor: HOLTZMAN RAFI
IPC: G06F3/043
Filed: 1998-03-05
Abstract: An ultrasound receiver assembly 14, 16 and 18 for use with conventional presentation boards 12 and pens.  The receiver assembly comprises two ultrasound receivers 14 and 16 with the first receiver 14 located adjacent to the surface of the presentation board 12 and the second ultrasound receiver 16 displaced from the first ultrasound receiver in a direction substantially perpendicular to the surface of the presentation board 12.  The receivers 14 and 16 are connected so as to generate a total output signal corresponding to the instantaneous sum of the ultrasound signals received at each, such that the receiver assembly is most sensitive to ultrasound signals incident from a plane adjacent to the presentation board 12.
Patent NZ-337744-A (NZ)
Title: Piston-to-cylinder seal for a pneumatic engine with pressure dependent, variable sealing diameter
Inventor: KOWNACKI CHARLES D
IPC: F02B75/34
Filed: 1999-09-09
Abstract: A piston seal (10) for a pneumatic engine, comprising a resilient annular skirt (16) integral with a substantially cylindrical sleeve (12). The seal (10) is secured to a cylindrical boss and compression face (14) of the piston (22). During low pressure phases, the diameter of the resilient skirt (16) is less than that of the internal diameter of the pneumatic cylinder (30) and effects no seal. The inward bias of the resilient annular skirt (16) is overcome during the high pressure phase and its diameter is increased to create a fluid tight seal.
Patent NZ-501256-A (NZ)
Title: Treatment of diabetes with thiazolidinedione and sulphonylurea
Inventor: BUCKINGHAM ROBIN EDWIN
IPC: A61K31/44
Filed: 1998-07-16
Abstract: An insulin sensitiser, 5-[4-[2-(N-methyl-N-(2-pyridyl)amino) ethoxy]benzyl]-thiazolidine-2,4-dione (Compound (I)) and/or a pharmaceutically acceptable derivative, and a sub-maximal amount of insulin secretagogue for the treatment of diabetes mellitus and conditions associated with diabetes mellitus, wherein the medicament comprises 2 to 12 mg of Compound (I).
Patent NZ-502393-A (NZ)
Title: The use of Bacillus thuringiensis PS66D3 for controlling homopteran pests
Inventor: SCHNEPF ERNEST H
IPC: A01N63/50
Filed: 1998-07-29
Abstract: A method for controlling a homopteran insect pest comprises contacting the pest with a toxin obtained from a Bacillus thuringiensis isolate selected from the group consisting of HD969, PS66D3 and PS50C and is toxic to a homopteran insect pest.  The toxin can be expressed in plant cells and may be a Cryl1B toxin obtained from Bacillus thuringiensis isolate HD969. Also disclosed is the gene encoding a toxin obtained from the Bacillus thuringiensis isolates of HD969 or DPS66D3 or a homopteran-active portion of the toxin and a host cell transformed with a toxin obtained from a Bacillus thuringiensis isolate or a homopteran-active portion of the toxin wherein the toxin is toxic to homopteran insect pests.
Patent NZ-502962-A (NZ)
Title: A diagnostic method for use in drug research or tumour therapy where inhibition of angiogenesis is a feature using a dual culture system in a ratio of 2:1 to 8:1 of human adult dermal fibroblasts to HUVEC
Inventor: GRANT EILEEN TENNANT
IPC: C12N5/071
Filed: 1998-09-25
Abstract: A multicellular i(in vitro) assay for modelling the combined stage of angiogenesis namely the proliferation, migration and differentiation stages of cell development, wherein the assay comprises providing a dual culture of endothelial cells together with another cell-type e.g. fibroblast exhibiting interaction to display the combined stages of angiogenesis i(in vitro). Preferably the assay system comprised the steps of: (a)	Setting up growth containers suitable for sustaining dual cell cultures and having a suitable culture medium for sustaining at least growth of endothelial cells (b)	Seeding a dual culture of human fibroblasts (preferably human adult dermal fibroblasts) and human endothelial (preferably human umbilical vein endothelial cells) cells to obtain a pre-determined target ratio (c)	Incubating without the provision of any exogenous growth factors (d)	Monitoring the progress of the cells from an initial proliferation phase until a confluent monolayer is produced (e)	Changing the culture medium at regular intervals throughout the proliferation, migration and differentiation stages of the cell development.
Patent NZ-503104-A (NZ)
Title: Pouring and container closure device
Inventor: ALLEN MICHAEL
IPC: B67B7/48
Filed: 1998-08-26
Abstract: A pouring device for a container, the pouring device (5a) comprising a first, rear portion (15a) and a second, front portion (20a) and means for retaining the device in association with a container, wherein in a first non-pouring position the second portion is in sealing engagement with the container, while, in use, depressing of the first portion causes at least part of the second portion to move from the first non-pouring position to a second pouring position.  Releasing the first portion causes the second portion to readopt the first non-pouring position.  The pouring device is preferably used for pouring oil into a vehicle's engine.  The device includes tamper evident means.  The pouring device can be used to control the rate of flow of oil from a container.
Patent NZ-507784-A (NZ)
Title: Use of compounds for the elevation of pyruvate dehydrogenase activity
Inventor: BUTLIN ROGER JOHN
IPC: C07D237/20
Filed: 1999-05-26
Abstract: Described is the use of compounds of formula (I) in the manufacture of a medicament for use in the elevation of pyruvate dehydrogenase (PDH) activity, wherein, C is optionally substituted phenyl or carbon-linked heteroaryl, and n is 1 or 2, and R1 is linked to ring C at a carbon ortho to the position of A-B attachment and is selected from C1-4 alkyl, halo-C1-4 alkyl, C1-4 alkoxy, halo-C1-4 alkoxy, C2-4 alkenyloxy, cyano, nitro, halo, trifluoromethylsulphanyl and hydroxy, or -X5-R81 wherein X5 is a direct bond, -O-, -S-, -SO2-, -OSO2O-, -NR82-, -CO-, -COO-, -OCO-, -CONR83-, -NR84CO-, -NR85COO-, -SO2NR86-, -NR87SO2-, -CH2-, -SO2NR88CO-, -OCONR89-, -CSNR90-, -NR91CS-, -NR92CSN93-, -NR94CONR100-, or R1 is -X6-R101 wherein X6 is a direct bond,  -CO-, -O-, -OCH2-, -S-, -SO-, -SO2- or -NR102-, wherein R101 is optionally substituted phenyl, and R2 and R3 are independently hydrogen, halo, optionally substituted C1-3 alkyl, or together with the carbon atom to which they are attached, form an optionally substituted 3-5 membered cycloalkyl ring, and A-B is selected from -NHCO-, -OCH2-, -NHCH2-, trans-vinylene, ethynylene, -NHCS-, or -COCH2-, and R4 is hydroxy, hydrogen, halo, amino, or methyl.