baber/WOPTO huggingface dataset:
Patent CY-1121567-T1 (CY)
Title: Εμβολια λοιμωδους βρογχιτιδας προερχομενα απο ομοιαζοντα me ib-qx στελεχη
Inventor: GEERLIGS HARMEN JACOB
IPC: A61K39/215
Filed: 2018-12-19
Abstract: Η παρούσα εφεύρεση σχετίζεται με ιούς λοιμώδους βρογχίτιδας (IB) προερχόμενους από έναν πρόσφατα ταυτοποιημένο γονότυπο ιού IB γνωστού ως IB-QX, ή από ιούς που σχετίζονται γενετικά με τον IB-QX, που στο παρόν αναφέρονται ως παρόμοιοι με IB-QX ιοί. Οι ιοί IB της εφεύρεσης μπορεί να είναι ζωντανοί και εξασθενημένοι ή απενεργοποιημένοι. Ζωντανοί, εξασθενημένοι ιοί IB της εφεύρεσης μπορούν να παραχθούν με σειριακή ανακαλλιέργεια ενός παρόμοιου με IB-QX ιού. Οι ιοί IB της εφεύρεσης είναι χρήσιμοι για, μεταξύ άλλων, εμβόλια κατά IB-QX και παρόμοιων με IB-QX ιών. Μέχρι σήμερα, γνωστά στελέχη εμβολίων των ιών IB έχουν αποδειχθεί ανεπαρκή για προστασία έναντι λοιμώδους βρογχίτιδας που προκαλείται από IB-QX και παρόμοιους με IB-QX ιούς.
Patent CY-1121125-T1 (CY)
Title: Συνθεσεις για τη θεραπευτικη αντιμετωπιση του πονου και/ή της φλεγμονης
Inventor: CARRENO SERRAÏMA CRISTINA
IPC: A61K38/17
Filed: 2019-01-15
Abstract: Συνθέσεις για τη θεραπευτική αντιμετώπιση του πόνου και/ή της φλεγμονής που περιλαμβάνουν τουλάχιστον ένα πεπτίδιο με γενικό τύπο (I) R1-AA-R2, τα στερεοϊσομερή, τα μίγματα τους και τα καλλυντικά και φαρμακευτικά αποδεκτά άλατα του. Πεπτίδιο με γενικό τύπο (I), τα στερεοϊσομερή του, τα μίγματα τους και τα καλλυντικά και φαρμακευτικά αποδεκτά άλατα του για τη θεραπευτική αγωγή του πόνου και/ή της φλεγμονής.
Patent CY-1123908-T1 (CY)
Title: Δισκιο με εντερικη επικαληψη
Inventor: RYU AKIO
IPC: A61K9/28
Filed: 2020-12-08
Abstract: Παρέχεται ένα δισκίο με εντερική επικάλυψη που περιέχει μια μεγάλη ποσότητα φαρμακευτικού συστατικού και έχει επαρκή αντοχή στην κρούση, χωρίς να σχηματίζει ένα παχύ στρώμα εντερικής επίστρωσης. Το δισκίο με εντερική επικάλυψη περιέχει (Α) ένα δισκίο πυρήνα που περιέχει ένα φαρμακευτικό συστατικό και έχει βάρος 1.000 mg ή περισσότερο. (Β) ένα στρώμα επικάλυψης που περιέχει ένα υδατοδιαλυτό πολυμερές που εφαρμόζεται στην επιφάνεια του πυρήνα του δισκίου και (Γ) ένα στρώμα εντερικής επικάλυψης που διαλύεται σε pΗ 7 ή υψηλότερο το οποίο εφαρμόζεται στην επιφάνεια του στρώματος επικάλυψης που περιέχει ένα υδατοδιαλυτό πολυμερές, όπου το άθροισμα της ποσότητας πολυμερούς του στρώματος επικάλυψης (Β) και της ποσότητας πολυμερούς του στρώματος επικάλυψης (Γ) είναι 10 έως 18 mg / cm2, η ποσότητα πολυμερούς της στρώσης επικάλυψης (Β) είναι 6 έως 12 mg/cm2 και η ποσότητα πολυμερούς της στρώσης επικάλυψης (Γ) είναι 3 έως 6 mg / cm.2.
Patent CY-1126112-T1 (CY)
Title: Φαρμακοτεχνικες μορφες που περιεχουν ενυδρη προπυλενογλυκολη δαπαγλιφλοζινης
Inventor: BINDRA DILBIR
IPC: A61K31/70
Filed: 2023-07-27
Abstract: Παρέχονται φαρμακοτεχνικές μορφές οι οποίες είναι υπό τη μορφή κάψουλων ή δισκίων για στοματική χρήση και οι οποίες περιλαμβάνουν την ένυδρη προπυλενογλυκόλη της δαπαγλιφλοζίνης η οποία είναι: ο Τύπος (Ia) ή ο Τύπος (Ib) και ένας φαρμακευτικώς αποδεκτός φορέας αυτών, η οποία φαρμακοτεχνική μορφή έχει σχεδιαστεί για άμεση απελευθέρωση. Οι φαρμακοτεχνικές μορφές χρησιμοποιούνται για τη θεραπευτική αντιμετώπιση του διαβήτη και των σχετικών νόσων.
Patent SI-1608655-T1 (SI)
Title: Pyrroloimidazole derivatives, their preparation, pharmaceutical compositions containing them, and their use as nootropic agents
Inventor: FARINA CARLO
IPC: A61K31/00
Filed: 2004-03-22
Abstract: Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.
Patent SI-1631707-T1 (SI)
Title: Non-fibrous polymer solution of para-aramid with high relative viscosity
Inventor: HENDRIKS ANTON JOHANNES JOSEF
IPC: D01F6/60
Filed: 2004-05-04
Abstract: The invention relates to a non-fibrous polymer solution essentially consisting of 1 to 8 wt. % para-aramid, at least 50 mole % of the aromatic moieties thereof being unsubstituted, in a mixture of a) a polar amide solvent selected from N-methyl-2-pyrrolidone, N,N′-dimethylformamide, N,N′-dimethylacetamide, tetramethylurea, and mixtures thereof; b) between 0.7 mole of an alkali or earth alkali chloride per mole amide groups of the para-aramid and 7.5 wt. % of the alkali or earth alkali chloride, and c) water; and wherein at least 50 wt. % of the formed hydrochloric acid has been neutralized to obtain a solution having a dynamic viscosity which is at least a factor three smaller than the dynamic viscosity of the polymer solution without neutralization. The invention further pertains to a process making the same and para-aramid pulp-like fiber, paper and film made from said polymer solution.
Patent SI-1945041-T1 (SI)
Title: Chewy sweet and method for preparing such a chewy sweet
Inventor: CLAESSENS MARIANNE
IPC: A23G3/00
Filed: 2005-11-07
Abstract: The invention relates on the one hand to a chewy sweet, comprising a gelatinizing agent for providing a chewy texture to the chewy sweet, wherein the gelatinizing agent consists of a gliadin-enriched wheat gluten fraction. On the other hand, the invention relates to a method for preparing such a chewy sweet, comprising the steps of a) dispersing the gliadin-enriched wheat gluten fraction in warm water; b) cooking up glucose syrup, sucrose and water at 120-140° C., until moisture content of the mass is <10%, preferably between 4 and 7%; c) adding the fat material and the one or more emulsifiers to the cooked-up syrup, during or after cooking; d) cooling the mixture of b) and c) to below 105° C.; e) mixing the syrup of d) with a) and the other ingredients; f) further cooling this mass; g) and bringing the cooled mass into the desired shape.
Patent SI-1963288-T1 (SI)
Title: Substituted oxazole derivatives with an analgesic action
Inventor: MERLA BEATRIX
IPC: A61K31/41
Filed: 2006-12-19
Abstract: 1-aminomethyl-4-oxazolylalkyl-cyclohexane derivatives (I), as racemates, enantiomers, diastereomers (and mixtures), bases and salts with acids are new. 1-aminomethyl-4-oxadiazolylalkyl-cyclohexane derivatives of formula (I), as racemates, enantiomers, diastereomers (and mixtures), bases and salts with acids are new. n : 0-2; R 1>aryl or heteroaryl attached through 1-3C alkyl, both optionally substituted, one or more times; R 2>aryl or heteroaryl, both optionally substituted, one or more times, and/or attached through a 1-3C alkyl; R 3> and R 4>1-6C alkyl (optionally unsaturated, linear or branched, optionally substituted one or more times) or aryl (optionally substituted one or more times and/or attached through 1-3C alkyl) or together they complete a 5-7 membered ring, saturated or unsaturated (but not aromatic), optionally containing an additional heteroatom (S, O or N), optionally substituted one or more times, and the ring may be fused to an aromatic ring; R 5> and R 6>hydrogen or 1-6C alkyl (optionally unsaturated and/or branched), but are not both hydrogen, or together they complete CH 2CH 2OCH 2CH 2 or (CH 2) 3-6; R 7> and R 8>1-4C alkyl (optionally unsaturated and/or substituted one or more times) or (hetero)aryl optionally substituted one or more times and attached through 1-3C alkyl, or together they form a 5-7 membered ring as defined above. An independent claim is included for a method for preparing (I) by reacting aldehyde (A), with amine NHR 4>R 3> (B) and isonitrile amide NC-CHR 1>CONR 7>R 8> (C) in organic solvent, e.g. (m)ethanol, at 30-100, preferably 40-80, [deg]C for 1-10 hours. [Image] [Image] ACTIVITY : Analgesic; Antidepressant; Uropathic; Antidiarrheic; Antipruritic; Antialcoholic; Tranquilizer. MECHANISM OF ACTION : (I) bind to the mu -opioid receptors. The compound [{4-[(4-benzyl-5-pyrrolidin-1-yl-oxazol-2-yl)piperidin-1-ylmethyl]-cyclohexyl}-(4-fluorophenyl)methyl]cyclohexyl}methyl)methylphenylamine caused 76% inhibition of the human mu receptor at a concentration of 1 mu M.
Patent SI-2130705-T1 (SI)
Title: Push rail cover
Inventor: WENSING UDO
IPC: B60J7/02
Filed: 2008-06-06
Abstract: The tarpaulin bow cover (2) has multiple running or guide rails (4) running on a loading surface (3) of a truck (1) along the longitudinal sides of the loading surface. A covering tarpaulin is provided, which is attached in a holding bow (6). The holding bow is provided with a drag axis, and comprises a deflection force achieving unit for achieving the deflection force.
Patent SI-2300889-T1 (SI)
Title: Method of guiding a vehicle
Inventor: ARNAUD DANIEL
IPC: G05D1/00
Filed: 2009-06-18
Abstract: The invention relates to a method of guiding a vehicle (1) comprising the following steps: exciting, during the displacement of the vehicle (1), at least one guidance element (4) made of a high-permeability magnetic material affixed to a support, such as a road (3), by way of excitation means (5); detecting the signal emanating from the guidance element (4) following the excitation by way of detection means (6, 7); gathering and processing the signal arising from the detection means (6, 7) so as to guide the vehicle (1). The excitation of the guidance element (4) is carried out in such a way as to saturate or modify the operating point of the guidance element (4) in its operating cycle, which then emits a frequency-rich signal, composed of a wave of fundamental frequency (fo) as well as waves of frequencies (nf0) which are multiplies of the value of the fundamental frequency, and called the harmonics, and in that the excitation is carried out way of a plurality of coils or of a radar generating a rotating excitation magnetic field.
Patent SI-2801625-T1 (SI)
Title: Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
Inventor: JOHNSON BANKOLE A
IPC: C12Q1/00
Filed: 2011-07-01
Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
Patent TR-200505075-T1 (TR)
Title: Birçok dopo ihtiva eden organik bileşiklerin imalat yöntemi
Inventor: MEUSEL ERICH
IPC: C07F9/6574
Filed: 2003-06-18
Abstract: Yeni, birçok DOPO ihtiva eden, reaktif, şimdiye kadar bilinen karşılaştmlabilir DOPO (9,10-dihidro-9-oksa-10-fosfa-fenantren-10-oksid) adduktlanna göre daha yüksek bir fosfor muhtevasına sahip olan organik bileşiklerin imalatına ilişkin bir yöntem ve ayrıca onların örneğin polyester ve polyamidler gibi termoplastik polimerlerin aleve karşı koruyucu donanımı için kullanılması ile ilgilidir, burada şimdiye kadar alışılagelmiş olandan daha düşük ilave miktarları ile aynı aleve karşı koruyucu etkiye ulaşılabilir ve böylece polimerlerin fiziksel, özel tekstil fiziksel özelliklerinin daha az etkilenmesi mümkün hale gelir. Birçok DOPO ihtiva eden adduktlann oluşumu, DOPO'nun reaktif gruplar taşıyan asetilenler ile bir katalizörün varlığında dönüştürülmesi aracılığı ile gerçekleşir.
Patent DE-3382639-T2 (DE)
Inventor: GROET SUZANNE
IPC: C12Q1/68
Filed: 1983-12-12
Granted: 1993-07-15
Abstract: Method of binding nucleic acid to a nucleic acid-binding support comprising depositing the nucleic acid onto the support and then contacting the nucleic acid and the support with a liquid binding solution which is compatible with the support and which contains an organic solvent which is capable of binding the DNA to the support, for a period of time sufficient to effect the binding.
Patent DE-3486262-T2 (DE)
Inventor: BUNDESEN PETER GREGORY
IPC: C12P21/08
Filed: 1984-03-16
Granted: 1994-06-16
Abstract: The invention relates to a method of preparation of monoclonal antibody derived from a crosslinked fibrin derivative including the steps of:(i) obtaining a crosslinked fibrin derivative or extract containing same; and(ii) forming antibody to said derivative or extract by cloning antibody producing cells from an animal having been administered thereto said derivative or extract.There is also provided a screening assay for use in the abovementioned method which includes the steps of:(A) coating a surface with antigen selected from(i) crosslinked fibrin derivative;(ii) extract containing said derivative; or(iii) fibrinogen degradation product.(B) contacting said antigen with monoclonal antibody derived from crosslinked fibrin derivative; and(C) subjecting the complex formed in step (A) to a signal amplification step.There is also disclosed an assay procedure for detection of the presence of a crosslinked fibrin derivative in an animal body fluid including the steps of:(i) contacting monoclonal antibody prepared from a crosslinked fibrin derivative with a fluid sample suspected of containing an antigen derived from a crosslinked fibrin derivative or comprising a crosslinked fibrin derivative perse; and(ii) subjecting the complex formed in step (1) to a signal amplification step.
Patent DE-3587789-T2 (DE)
Inventor: DAHLIN AKE BERTIL INGEMAR
IPC: F16C11/00
Filed: 1985-06-24
Granted: 1994-10-27
Abstract: Thread joint consisting of externally threaded bodies (34, 35) where one body has an axial recess (38) into which a pin (37) of another body can be pushed. On the bottom of the recess and furthest on the pin, respectively, a key handle (41) is arranged. When the pin is pushed into the recess with a correct position of the key handle the threads of the bodies enter into each other and the common device can be screwed through a nut.
Patent DE-3751829-T2 (DE)
Inventor: KRAFT KARL F
IPC: A61B5/055
Filed: 1987-07-25
Granted: 1996-10-31
Abstract: The invention provides the use of a physiologically compatible chelate complex of a chelating compound and a paramagnetic ion of a lanthanide element having an atomic number in the range 57 to 70 or of a transition metal having an atomic number selected from 21 to 29, 42 and 44 and of a non-paramagnetic organic calcium salt for the preparation of a magnetic resonance imaging contrast medium by admixture of said complex and said organic salt. The admixed calcium serves to enhance the biotolerability of the paramagnetic chelate containing MRI contrast medium.
Patent DE-3780184-T2 (DE)
Inventor: BERTOLA MAURO ATTILIO
IPC: C12N/
Filed: 1987-01-06
Granted: 1992-12-24
Abstract: A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R₁ represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula wherein R₂ is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.
Patent DE-3787198-T2 (DE)
Inventor: RUPPRECHT WERNER
IPC: H01B17/26
Filed: 1987-04-07
Granted: 1994-04-28
Abstract: A high voltage bushing is formed from a plurality of insulating layers. Conductive layers are interleaved with the insulating layers, and are electrically insulated from each other. The ends of the conductive layers are overlapped by stress grading layers, to minimise the electrical stress on the bushing.
Patent DE-3874748-T2 (DE)
Inventor: CARMEN RALPH
IPC: G01D5/245
Filed: 1988-12-07
Granted: 1993-04-22
Abstract: A magnetic rotary encoder system includes a magnetoresistive sensor (10) having a magnetoresistive element array (R1-R6) which is selectively connected to accommodate a number of different diameter encoder wheels (12) each wheel of which contains a different number of pieces of magnetic information recorded at corresponding different wavelengths. A sensing and conditioning circuit (30) is coupled to the magnetoresistive sensor and detects changes in resistance of the magnetoresistive elements when a magnetic field produced by a magnetic pole causes the magnetoresistive resistance to drop. Ouput signals are provided in quadrature to increase the resolution of the system.
Patent DE-3881166-T2 (DE)
Inventor: YOSHIKAWA KENSEI
IPC: C07D211/46
Filed: 1988-11-18
Granted: 1993-09-02
Abstract: Sulfonanilide compounds represented by the formula <CHEM> wherein R<1> is a lower alkyl group or a trifluoromethyl group, R<2> is a cycloalkylidenemethyl group, a group of the formula -A-R<3> (wherein A is an oxygen atom, a sulfur atom, a sulfonyl group or a sulfinyl group and R<3> is a cycloalkyl group having 5 - 8 carbon atoms; a cycloalkyl group having 5-8 carbon atoms substituted by one or two of a lower alkyl group, an oxo group, a hydroxyl group or a methanesulfonyloxy group; a tetrahydropyranyl group; a tetrahydrothiopyranyl group; or a 1-methylpiperidyl group) or a group of the formula -B-R<4> wherein B is a carbonyl group, a hydroxymethylene group or a methylene group, R<4> is a cycloalkyl group having 5-8 carbon atoms) and the pharmaceutically acceptable salts thereof have anti-inflammatory activity.
Patent DE-3886008-T2 (DE)
Inventor: COURY FRANK
IPC: A61F5/453
Filed: 1988-09-07
Granted: 1994-03-31
Abstract: A male external catheter comprising a condom-like sheath having at least one of its surfaces flocked with a fabric is disclosed. The flocked catheter provides greater comfort, absorbs moisture, and is easier to apply than prior art sheaths.
Patent TR-199901614-T2 (TR)
Inventor: KOCH BENOIT
IPC: C08F4/69
Filed: 1997-10-16
Abstract: Bir inorganik tasiyici üzerine çöktürülmüs krom oksit esasli bir katalitik kati yardimiyla elde edilen, etilen ve en az bir alfa-olefinden olusan bir kopolimer olup, söz konusu kopolimer, g/10 dak. cinsinden ifade edilen bir eriyik akis indisi HLMI ye, her kg kopolimer içindeki g alfa-olefin olarak ifade edilen bir alfa-olefin miktarina Q, kg/m3 olarak ifade edilen ve en az (952.75+5.40 x log HLMI-0.79 x Q) degerine esit olan bir standart yogunluga SD ve dinamik viskoziteler orani  0/ 2 nin en az (23.67-6.67 x log HLMI) degerine esit olmasiyla karakterize edilen, nisbeten genis bir moleküler kütle dagilimina sahiptir.
Patent AT-E437759-T2 (AT)
Inventor: POWER GARY
IPC: B42D15/00
Filed: 1999-01-14
Granted: 2009-08-15
Abstract: Security document (1) with security indicia (21) for preventing unauthorised reproduction, the security indicia being detectable in transmitted light, wherein the security indicia are located within the bounds of a security pattern (20) acting to visually conceal the security pattern in reflected light. The security pattern may be formed of one or more elements (25) and may have a complexity selected to enable the concealment of the security indicia (21).
Patent DE-60001230-T2 (DE)
Inventor: TRIBELSKY ZAMIR
IPC: B01J19/10
Filed: 2000-04-21
Granted: 2003-11-13
Abstract: The present invention relates to a method for disinfecting and purifying liquids and gasses comprising; a) passing said liquids or gasses through a reactor or a combination of reactors, having a truncated compounded concentrator geometry; and b) simultaneously delivering and concentrating diversified electromagnetic and acoustic energies into a specific predetermined inner space of said compounded concentrator reactor, forming a high energy density zone in said reactor or reactors over a predetermined period of time. The reactor according to the present invention is preferably a compounded parabolic concentrator or a compounded ellipsoidal concentrator. The electromagnetic energy delivered and concentrated into and inside the reactor can be of any range of the electromagnetic spectrum, such as ultra-violet, visible, infra-red, microwave etc., or combination thereof. The acoustic energy is of any suitable frequency. The radiation source delivering the electromagnetic radiation can be enclosed within the reactor or can be external to the reactor.
Patent DE-60002209-T2 (DE)
Inventor: CLARK GERARD
IPC: A47L9/28
Filed: 2000-07-20
Granted: 2004-03-04
Abstract: A robotic floor cleaning device comprises a chassis (10), motor-driven wheels (11) supporting the chassis (10), a motor-driven suction fan (9), a dirty air inlet (2) and a motor-driven rotatable agitator (4) at the dirty air inlet (2) for agitating the surface. A control system navigates the device around a room and distributes power to the motor-driven wheels (11) and to the agitator (4). The control system detects when the agitator (4) has jammed (100, 102) and, in the event of a jam, attempts to clear the jam (104, 106). After successfully clearing the jam the control system turns the agitator (4) off (114, 116, 118) or navigates the cleaning device around the location at which the jam occurred (119). The cleaning device can store the location of the jam for use in preventing further jams when the cleaning device returns to a similar position in the room.
Patent DE-60022134-T2 (DE)
Inventor: COJAN JEAN-YVES
IPC: C04B28/16
Filed: 2000-06-22
Granted: 2006-06-29
Abstract: An hydraulic binder including gypsum, anhydrite, or their mixture is used for stabilizing arsenical wastes. An Independent claim is included for a method of stabilizing arsenical wastes by using the hydraulic binder. The arsenical waste is first mixed with an iron salt, and then the binder is added. The iron salt addition is preferably a mixture of two salts selected from iron, preferably ferrous, sulfate, iron chloride or iron nitrate.
Patent DE-60022393-T2 (DE)
Inventor: VAN DOORN ALEXANDER
IPC: C07C227/02
Filed: 2000-12-15
Granted: 2006-06-01
Abstract: A process for the preparation of alkylene diamine triacetic acid (derivatives) which comprises the conversion of an alkylene diamine (derivative) to a metal salt of an alkylene diamine triacetic acid (derivative). The reaction is carried out in the presence of a polyvalent metal ion Ma+ and the entire reaction is carried out under hydrolyzing conditions if any of the reactants contain or form nitrile or amide groups.
Patent DE-60030482-T2 (DE)
Inventor: SEINO AKIHIRO
IPC: C09K17/32
Filed: 2000-08-31
Granted: 2007-03-29
Abstract: A soil improving agent comprising malic acid and/or grape sugar is mixed with soil to enable the ground after consolidation to have good water permeability and strength.
Patent DE-60107819-T2 (DE)
Inventor: BURNETT M
IPC: A61J1/00
Filed: 2001-02-08
Granted: 2006-02-16
Abstract: This invention relates to a delivery system which comprises a topical skin care agent, a top layer and a bottom layer where at least one of said top layer and said bottom layer comprises an apertured film having protuberances therein, where said top layer and said bottom layer are attached to eachother leaving a pouch between said top layer and said bottom layer, where said protuberances of said apertured film face said pouch, and where said pouch contains said topical skin care agent.