Patent SG-11201906852X-A (SG)
Title: Treatment of diuretic resistance
Inventor: TESTANI JEFFREY
IPC: C07K16/00
Filed: 2018-02-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT o mono °nolo Ho Ho Ho oimIE (10) International Publication Number WO 2018/144773 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61P 7/10 (2006.01) C07K 16/00 (2006.01) A61P 13/12 (2006.01) (21) International Application Number: PCT/US2018/016508 (22) International Filing Date: 01 February 2018 (01.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/453,257 01 February 2017 (01.02.2017) US (71) Applicants: YALE UNIVERSITY [US/US]; Two Whit- ney Avenue, New Haven, CT 06511 (US). CORVIDIA THERAPEUTICS, INC. [US/US]; 35 Gatehouse Drive, Waltham, MA 02451 (US). (72) Inventor; and (71) Applicant: LO, Chih-Hung [US/US]; c/o Corvidia Ther- apeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). (72) Inventors: TESTANI, Jeffrey; 532 Tanner Marsh Road, Guilford, CT 06437 (US). RAO, Veena; 844 Tall Tim- ber Road, Orange, CT 06477 (US). KAKKAR, Rahul; c/o Corvidia Therapeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). DEVALARAJA, Madhav N.; c/o Cor- vidia Therapeutics, Inc., 35 Gatehouse Drive, Waltham, MA 02451 (US). (74) Agent: SUN, Danqiong et al.; Fenwick & West LLP, Sili- con Valley Center, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: TREATMENT OF DIURETIC RESISTANCE DE by plasma IL-6 Tertile 300 E:3 Tertile 1 Tertile 2 Tertile 3 w 100 Kruskal-Wall is ANOVA p=0.0018 FIG. 1B 1-1 (57) : The present disclosure provides methods of treating diuretic resistance by administering an IL-6 antagonist to patients © who require diuresis. In typical embodiments, the patient has heart failure. Optionally, the patient has elevated urine levels of IL-6, C plasma levels of IL-6, or both urine and plasma levels of IL-6. [Continued on next page] • 200 • • • • MN WO 2018/144773 Al 1#110figinigE1013010HOMOBEIHREM# (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))