baber/WOPTO huggingface dataset:
Patent DE-68988-T1 (DE)
IPC: H01F7/02
Filed: 1982-06-18
Abstract: The method starts from a magnet (14) having its opposite ends magnetized such that north and south pole be equally strong. One pole (N) of the locking magnet is connected to the opposite pole (S) of a second magnet (30). A magnetic field is applied to the opposite end (S) of the locking magnet, and is collapsed to reverse the polarity of said opposite end, whereby the strenght of the magnetic pole adjacent the second magnet becomes relatively weak compared to the pole adjacent the magnetic field. Use in order to prevent undesirable interaction between the locking magnets in magnetic locksets.
Patent DE-115993-T1 (DE)
IPC: F16L55/16
Filed: 1984-01-30
Abstract: An internal lining for ducts (C) is provided by introducing into one end of the duct an assembly (E) which comprises a sleeve (5) and an inflatable system (2) and which is provided with heating means for applying a sheath (1) impregnated with a resin against the inner wall of said duct (C). After partial polymerization at least of the resin, the sheath (1) adheres to the inner wall of the duct. The system (2) is then deflated, the heating stopped and the assembly (E) withdrawn from the duct. With the length of the duct a multiple of the length (l) of an assembly (E), the operation is repeated by introducing into the duct successively a multiplicity of sheaths (1) until the inner wall of the duct (C) is provided with an internal lining over the whole of its length.
Patent DE-692046-T1 (DE)
Inventor: STOWELL CLAUDE
IPC: B44B5/00
Filed: 1993-04-01
Abstract: A method and apparatus for imprinting a predefined pattern in a freshly rolled asphalt surface to simulate the appearance of bricks, cobblestones, interlocking paving stones or the like. A pliable, grid-like template is progressively compressed into the asphalt surface using a drum roller or other surface compactor. The template is then manually lifted clear of the asphalt surface and the asphalt is allowed to harden. The patterned asphalt surface may be treated with a thin coating of colored concrete to enhance the brick and mortar effect.
Patent ES-2916649-T1 (ES)
Title: Composiciones y usos para el tratamiento de la esclerosis múltiple
Inventor: LUKASHEV MATVEY
IPC: G01N33/68
Filed: 2008-02-07
Abstract: Una composición farmacéutica para usarse en el tratamiento de la esclerosis múltiple, comprendiendo la composición: (a) fumarato de dimetilo y/o fumarato de monometilo, y (b) uno o más excipientes farmacéuticamente aceptables, donde la composición se va a administrar por vía oral a un sujeto que necesita tratamiento para la esclerosis múltiple, y donde la dosis de fumarato de dimetilo o fumarato de monometiloque se va a administrar es de aproximadamente 480 mg a aproximadamente 720 mg por día.
Patent CY-1107529-T1 (CY)
Inventor: WHYTE WILLIAM
IPC: H04L9/08
Filed: 2007-01-10
Abstract: A method of constructing shares in a secret is disclosed. The method operates in a network comprising a number of computing devices, each arranged to securely store at least one share in the secret k for which n shares are required to reconstruct the secret and to which access to a number m of the shares can be reliably provided at any given time. The method comprises the steps of: determining n shares for an n-of-n secret sharing scheme, each share comprising a value y; storing at least some of the shares in the computing devices such that at least m of the n shares are reliably accessible; determining the shared secret k according to the shares y; determining a further (n-m) shares consistent with the shared secret k and the shares y; and storing the additional shares in a reliably accessible location.
Patent CY-1107066-T1 (CY)
Inventor: TOURRETTE PHILIPPE
IPC: A61M5/28
Filed: 2007-08-28
Abstract: The syringe (6), having a barrel (8), a plunger (9) and a needle (10), has part of the barrel pre-filled with a viscoelastic fluid (11), e.g. 1 per cent sodium hyaluronate. Another part of the barrel is filled with a second viscoelastic fluid (12), e.g. hyaluronan or polyacrylamide, with a molecular weight higher or lower than the first, designed to be injected through the same needle following injection of the first fluid. In addition, the syringe barrel has a visual mark (14) corresponding to the bottom position of the plunger once all the first fluid has been injected. A variant of the design has the barrel filled with three different fluids.
Patent CY-1106958-T1 (CY)
Inventor: WARSHAKOON NAMAL CHITHRANGA
IPC: A61K31/4412
Filed: 2007-10-25
Abstract: Compounds of Formula (I) are effective in the treatment of a microbial infection.
Patent CY-1111514-T1 (CY)
Inventor: STIEWE GUNTHER
IPC: C12N15/82
Filed: 2011-02-17
Abstract: SUMMARY OF THE INVENTION   This invention relates to a nuclear conditional male sterility system in Brassica napus. Embodiments of the invention provide for the (male sterile) prebasic female (MsMsrfrf), the (male fertile) maintainer line (msmsrfrf), the (male sterile) basic female line (Msmsrfrf), and hybrid lines. Further provided are methods for the production of those lines. Further embodiments of the invention relate to markers associated to the sterility, fertility and maintainer alleles and the use of those markers in providing a hybrid system.
Patent CY-1112155-T1 (CY)
Inventor: CAMPBELL JOHN
IPC: A01N31/02
Filed: 2011-12-06
Abstract: Pesticides based on vicinal diols are available to control arthropod ectoparasites such as  Pediculus humanus, Dermatophagoides pteronyssinus, Musca domestica, the Blattidae, Blatella Germanica,  and  Periplaneta Americana,  by introducing to the locus of the infestation of the pest, a composition containing as active ingredient a vicinal diol.
Patent CY-1113889-T1 (CY)
Title: Βελτιωμενος αντιστρεπτος, χαμηλου κοστους, κατανεμημενος αισθητηρας οπτικης ινας με υψηλη χωρικη αναλυση
Inventor: EGALON CLAUDIO OLIVEIRA
IPC: G02B6/34
Filed: 2012-03-01
Abstract: Ένας αισθητήρας οπτικής ίνας σε φασματοσκοπική βάση περιλαμβάνει μία ευαίσθητη οπτική ίνα, μία πηγή φωτός εξέτασης, μία παροχή ισχύος, ένα μέσο ανίχνευσης, ένα μέσο επεξεργασίας σήματος και ένα μέσο ένδειξης. Η ευαίσθητη οπτική ίνα έχει έναν πυρήνα και ένα περίβλημα - όπου το εν λόγω περίβλημα έχει τουλάχιστον μία ευαίσθητη περιοχή, η οποία επηρεάζεται οπτικά από την παρουσία τουλάχιστον ενός προς μέτρηση μεγέθους. Η πηγή φωτός εξέτασης γειτονικά προς την ευαίσθητη ίνα φωτίζει εγκάρσια την ίνα εις την εν λόγω ευαίσθητη περιοχή από το εξωτερικό. Το φως εξέτασης τροποποιείται από την ευαίσθητη ίνα, συζευγνύεται εντός του πυρήνα οπτικής ίνας είτε ως οδηγούμενοι ρυθμοί είτε ως ρυθμοί διαρροής ως ένα φωτεινό σήμα και οδηγείται προς ένα μέσο ανίχνευσης που ευρίσκεται εις το τέλος της οπτικής ίνας. Το μέσο ανίχνευσης συσχετίζει την ένταση του φωτεινού σήματος με ένα ηλεκτρικό σήμα και μεταδίδει το ηλεκτρικό σήμα προς το μέσο επεξεργασίας σήματος, όπου το ηλεκτρικό σήμα συσχετίζεται προς την ποσότητα που μετράται. Η συσχετισμένη ποσότητα μεταδίδεται και εμφανίζεται εις το μέσο ένδειξης.
Patent CY-1113353-T1 (CY)
Title: Φαρμακοτεχνικη μορφη αντι-τνf-αλφα αντισωματος
Inventor: KRAUSE HANS-JUERGEN
IPC: A61K47/26
Filed: 2012-07-17
Abstract: Περιγράφεται υγρή υδατική φαρμακοτεχνική μορφή, η οποία έχει υψηλή συγκέντρωση πρωτεΐνης, pΗ μεταξύ περίπου 4 και περίπου 8 και ενισχυμένη σταθερότητα.
Patent CY-1113184-T1 (CY)
Title: Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου
Inventor: SÖDERVALL MARJA
IPC: C07C67/31
Filed: 2012-07-26
Abstract: Η παρούσα εφεύρεση αφορά μέθοδο για την παρασκευή θεραπευτικώς πολύτιμων παραγώγων τριφαινυλβουτενίου, ειδικώς ospemifene ή fispemifene, τύπου (Ι).
Patent CY-1117543-T1 (CY)
Title: Αναστολεις βητα-σεκρετασης
Inventor: BUKHTIYAROV YURI
IPC: C07D407/06
Filed: 2016-04-19
Abstract: Η παρούσα εφεύρεση σχετίζεται με σπειροκυκλικές ακυλογουανιδίνες και με τη χρήση τους ως αναστολέων της δράσης του ενζύμου β-σεκρετάσης (BACE1), με φαρμακευτικές συνθέσεις που περιέχουν αυτές και με μεθόδους χρήσης αυτών ως θεραπευτικών παραγόντων στη θεραπευτική αντιμετώπιση νευροεκφυλιστικών διαταραχών, διαταραχών που χαρακτηρίζονται από έκπτωση των γνωστικών λειτουργιών, μείωση των γνωστικών λειτουργιών, άνοια και παθήσεων που χαρακτηρίζονται από παραγωγή συσσωρεύσεων β-αμυλοειδούς.
Patent CY-1119977-T1 (CY)
Title: Ευελικτη διαδικασια για την επεξεργασια του διαλυτη που χρησιμοποιειται για την εξορυξη φυσικου αεριου
Inventor: ESQUIER JÉRÉMIE
IPC: C07C31/20
Filed: 2018-01-10
Abstract: Η εφεύρεση αφορά σε μία ευέλικτη διαδικασία για τον καθαρμό ενός διαλύτη που αναστέλλει τον σχηματισμό ένυδρων ενώσεων κατά τη διάρκεια της επεξεργασίας του αερίου, και συγκεκριμένα της μονοαιθυλενογλυκόλης (MEG), όπου ο εν λόγω διαλύτης έχει σημείο βρασμού το οποίο είναι υψηλότερο από αυτό του νερού και, σε τουλάχιστον ένα χρονικό σημείο, αναμιγνύεται με νερό και άλατα. Η μέθοδος λειτουργεί διαφορετικά με την ίδια εγκατάσταση ανάλογα με την περιεκτικότητα σε άλατα της MEG που πρόκειται να υποβληθεί σε επεξεργασία. Η διαδικασία λειτουργεί σύμφωνα με τη λεγόμενη φάση του "reclaiming" (διαχωρισμός των αλάτων υπό κενό που ακολουθείται από απόσταξη υπό κενό), όταν η περιεκτικότητα σε άλατα υπερβαίνει το όριο καθίζησης, διαφορετικά η διαδικασία λειτουργεί στη φάση αναγέννησης (χωρίς διαχωρισμό των αλάτων και χωρίς λειτουργία υπό κενό). Πλεονεκτικά, η διάταξη πραγματοποιείται υπό τον έλεγχο ενός μέσου δοσολογίας των αλάτων.
Patent CY-1120563-T1 (CY)
Title: Διαταξη υγιεινης με βελτιωμενη καταναλωση για ειδη υγιεινης
Inventor: BAIGUERRA GIANPAOLO
IPC: E03D9/03
Filed: 2018-05-15
Abstract: Η διάταξη υγιεινής με βελτιωμένη κατανάλωση για είδη υγιεινής (10, 10') περιλαμβάνει απορρυπαντικό ή/και αποσμητικό σε μορφή στερεού τεμαχίου (20) και μέσο σύμπλεξης (30) με περιμετρικό χείλος WC (100), όπου το μέσο σύμπλεξης (30) περιλαμβάνει τμήμα σύμπλεξης με το WC (31) και τμήμα σύμπλεξης (33, 34, 35) με το εν λόγω στερεό τεμάχιο (20), και όπου το στερεό τεμάχιο (20) περιλαμβάνει τουλάχιστον μια επίπεδη οπίσθια επιφάνεια (21) για σύμπλεξη με το μέσο σύμπλεξης (30), όπου το τμήμα σύμπλεξης με το στερεό τεμάχιο (20) περιλαμβάνει επίπεδη διάτρητη πλάκα (35) που έχει τουλάχιστον τρεις πείρους (36) κάθετους ως προς αυτήν και στραμμένους στην αντίθετη πλευρά ως προς το τοίχωμα του WC προκειμένου το στερεό τεμάχιο (20) να τοποθετείται με πίεση πάνω σε αυτούς, όπου η επίπεδη διάτρητη πλάκα (35) έχει διάσταση μικρότερη ή το πολύ ίση με αυτήν της επίπεδης οπίσθιας επιφάνειας (21) του στερεού τεμαχίου (20).
Patent CY-1120859-T1 (CY)
Title: Μεθοδος για την παρασκευη toy (3s,3s') 4,4'-δισουλφανοδιυλοδις (3-αμινοβουτανο 1-σουλφονικου οξεος)
Inventor: BALAVOINE FABRICE
IPC: C07C323/66
Filed: 2018-09-19
Abstract: Η παρούσα εφεύρεση σχετίζεται με μια νέα μέθοδο πέντε σταδίων για την παρασκευή του (3S,3S') 4,4'-δισουλφανοδιυλοδις (3-αμινοβουτανο 1-σουλφονικού οξέος) από τον (S)-αιθυλο 2-(βενζυλοξυκαρβονυλαμινο)-4-(νεοπεντυλοξυσουλφονυλο)βουτανοϊκό εστέρα Α.
Patent CY-1120787-T1 (CY)
Title: Συγκροτημα βαλβιδας για εναν εμβολοφορο συμπιεστη και εμβολοφορος συμπιεστης
Inventor: DAHMS PETER
IPC: F04B39/12
Filed: 2018-10-24
Abstract: Ένα συγκρότημα βαλβίδας για έναν εμβολοφόρο συμπιεστή παρουσιάζει ένα περίβλημα, στο οποίο τοποθετούνται τουλάχιστον μία βαλβίδα εισόδου και τουλάχιστον μία βαλβίδα εξόδου και το οποίο παρουσιάζει μία πρώτη επιφάνεια προς την πλευρά της κεφαλής κυλίνδρου και μία δεύτερη αντίθετα προσανατολισμένη επιφάνεια προς την πλευρά του κυλίνδρου, οι οποίες εκτείνονται εγκάρσια προς έναν κατά μήκος άξονα του συγκροτήματος βαλβίδας. Ένα περιμετρικό τοίχωμα του περιβλήματος του συγκροτήματος βαλβίδας που περιβάλλει τον κατά μήκος άξονα του συγκροτήματος βαλβίδας παρουσιάζει τουλάχιστον ένα τμήμα επαφής, το οποίο προβλέπεται για την επαφή σε μία επιφάνεια επαφής στον κύλινδρο ή στην κεφαλή κυλίνδρου και το οποίο εκτείνεται εγκάρσια προς τον κατά μήκος άξονα του συγκροτήματος βαλβίδας.
Patent GR-960300024-T1 (GR)
Title: Terfenadine metabolites and their optically pure isomers for treating allergic disorders
Inventor: YOUNG JAMES W
IPC: A61K45/06
Filed: 1996-05-31
Abstract: Use of a composition comprising a compound of formula I:   
or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.
Patent SI-1356813-T1 (SI)
Title: Antibacterial compositions comprising metal phthalocyanine analogues
Inventor: RONCUCCI GABRIO
IPC: C09B47/00
Filed: 2002-04-25
Abstract: The present invention relates to pharmaceutical compositions comprising metal phthalocyanine analogues of formula (I) and metal chelating compounds: <CHEM> having a good bioavailability and enhanced photoinactivation properties against Gram negative bacteria; and to their use for in vivo/ex vivo applications, such as blood and blood derivatives sterilization. <IMAGE>
Patent SI-1707496-T1 (SI)
Title: Package formed from at least one flexible film
Inventor: LENOIR NICOLAS
IPC: B65D75/00
Filed: 2005-03-29
Abstract: The package (10) formed from at least one flexible film delimiting an initially closed space comprises: 
- two principal longitudinal walls (14A, 14B); and 
- at least one intermediate wall (16A, 16B) disposed between the two principal walls (14A, 14B) in order to delimit the said initially closed space, the or each intermediate wall (16A) being at least locally curved towards the interior of the initially closed space. It has a weakened line (30) produced at least partially in a curved region (19A) of the intermediate wall (16A) and continuing over at most three-quarters of the width of each principal wall (14A, 14B).
Patent SI-1873166-T1 (SI)
Title: Improved sgp 130Fc dimers
Inventor: WATZIG GEORG
IPC: C07K14/00
Filed: 2006-06-30
Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala 234 -Glu 235 -Gly 236 -Ala 237 . Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.
Patent SI-2009351-T1 (SI)
Title: Coal dust burner for igniting fuel fed into thick flow supplies
Inventor: EHMANN MARTIN
IPC: F23C6/00
Filed: 2008-06-19
Abstract: A burner (1) comprises a fuel conveying tube (7) and a primary air tube (9) concentrically arranged within the fuel conveying tube. The burner is connectable to a feed line which conveys a pulverized fuel in a dense phase. An inside space of the primary air tube is connectable to a primary air feed line (18). A fuel conveying space (13) which is formed between the primary air tube and fuel conveying tube is connectable to the feed line which feeds the pulverized fuel in dense phase to the burner. A burner comprises a fuel conveying tube, and a primary air tube concentrically arranged within the fuel conveying tube. A mouth of discharge side of the primary air tube terminates at a distance to a mouth of a discharge side of the fuel tube. The burner is connectable to a feed line which conveys a pulverized fuel in a dense phase. An inside space of the primary air tube is connectable to a primary air feed line. A fuel conveying space which is formed between the primary air tube and fuel conveying tube is connectable to the feed line which feeds the pulverized fuel in dense phase to the burner. An independent claim is included for method for combusting particulate fuel in the burner.
Patent SI-2644698-T1 (SI)
Title: Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
Inventor: IGAWA TOMOYUKI
IPC: C12P21/00
Filed: 2011-11-17
Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
Patent SI-3021763-T1 (SI)
Title: Perfected device for the transosseous insertion of suture threads
Inventor: MANTOVANI MATTEO
IPC: A61B17/00
Filed: 2014-06-18
Abstract: The invention concerns a perfected device for the transosseous insertion of suture threads. This device comprises a main body (1) supporting a protruding cannula (3) provided with an active end (30); the device comprises a flexible threadlike element (4), on which there are fashioned a sharp tip (40) and an opening (41) that serves for the threading of at least one suture thread (5), said element (4) being housed in a coaxially sliding manner inside said cannula (3) and, on command, exiting from the active end (30) of the cannula, assuming a curved position; the device comprises first means for producing the coaxial movement of the threadlike element (4) in the two directions with respect to the cannula (3) and second means for producing a coaxial movement of the threadlike element in the exiting direction from the cannula (3); for a short tract, the movement produced by the second means is disengaged from the advancement of the threadlike element produced by the first means.
Patent SI-3056297-T1 (SI)
Title: Use of a feeder insert and method of preparing a casting mould with vertical mould splitting
Inventor: ZUMBUSCH LARS
IPC: B22C11/00
Filed: 2016-02-09
Abstract: A use of a feeder insert, having a volumetric center of gravity which is offset in relation to the opening axis of the passage opening of said feeder insert, in the manufacture of a casting mold having a vertical mold separation and a feeder insert which for dense feeding of the mold cavity during the casting procedure is attached to the casting mold, is described, wherein the feeder insert is positioned in a prefabricated mold part of the casting mold such that the opening axis of said feeder insert runs below the volumetric center of gravity of the latter.
Patent DE-3687060-T2 (DE)
Inventor: HUNT WILLIAM
IPC: A61G7/00
Filed: 1986-05-09
Granted: 1993-05-27
Abstract: PCT No. PCT/GB86/00250 Sec. 371 Date Jan. 21, 1987 Sec. 102(e) Date Jan. 21, 1987 PCT Filed May 9, 1986 PCT Pub. No. WO86/06624 PCT Pub. Date Nov. 20, 1986.A patient support appliance is provided of the kind formed from a plurality of inflatable air sacs, mounted on an articulating base and extending transversely of the base so as to provide, when inflated, a surface for supporting a person thereon. The base is divided into sections lengthwise of the appliance and the air sacs arranged in groups corresponding to said sections. An airblower for supplying air to the sacs is suspended from said base or mounted on a supporting frame. Air from the blower is fed to the appliance by a main air supplying conduit via a distribution chamber and individual air supply tubes lead from the distribution chamber to the groups of sacs. Pressure regulating valves are provided to regulate individually the pressure of air in the air supply tubes so that the pressure of air in each group can be regulated independently of the others. Means are provided for exhausting air rapidly from the distribution chamber, e.g. by opening a plate covering a hole in the chamber, whereby the sacs may be quickly deflated, e.g. for an emergency or other nursing procedures.
Patent DE-3787058-T2 (DE)
Inventor: GROVER WAYNE DAVY
IPC: H04J3/07
Filed: 1987-06-18
Granted: 1993-12-09
Abstract: In a high-speed fiber-optic tranmission system, data streams are synchronized using fixed stuffing before being multiplexed for transmission. The fixed stuffing information is replaced with forward error correction (FEC) information, whereby FEC is effected without any increase in transmission speed. FEC information blocks of each data stream can be synchronized to the frame timing of the transmission system, or they can be relatively unsynchronized. In the latter case, an FEC decoder acts in a self-framing manner to synchronize itself to the FEC information blocks of the respective data stream.
Patent DE-3851563-T2 (DE)
Inventor: POLLOCK THOMAS J
IPC: C12P19/06
Filed: 1988-04-14
Granted: 1995-04-13
Abstract: Method comprises (a) culturing a Xanthomonas campestris (XC) strain having a xanthan-increasing modification selected from (i) a mutation causing rifampicin resistance, (ii) a mutation causing bacitracin resistance and (iii) exogenous genetic information controlling the synthesis of xanthan and (b) sepg. xanthan from the culture medium. The modified XC strains are also claimed. Also claimed is an isolated DNA sequence encoding genetic information controlling the synthesis of xanthan.
Patent DE-3851669-T2 (DE)
Inventor: KURTZ NEIL
IPC: C07D401/12
Filed: 1988-06-23
Granted: 1995-02-02
Abstract: Gepirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia and phobic anxiety.
Patent DE-3874596-T2 (DE)
Inventor: CARMES FRANCIS
IPC: B61L5/06
Filed: 1988-05-02
Granted: 1993-02-18
Abstract: An operating device for a railroad switch, the device comprising a right drive rod (5) connected to a right point blade (1), a left drive rod (6) connected to a left point blade (2), and a moving carriage (7) driven by a motor between a right locking plate (12) and a left locking plate (13). The plate is held in position by a frame (36). The right drive rod (5) is situated between the right locking plate (12) and the carriage (7) and being received in a right groove (14) of the carriage. The left drive rod (6) is situated between the left locking plate (13) and the carriage (7) by being received in a left groove (15) of the carriage. Each drive rod (5, 6) is provided with two floating pegs (8 to 11) extending perpendicularly to the grooves and each is received in a corresponding notch (16 to 19) in the rod. Each locking plate includes at least one vertical locking recess (20, 21) having sloping side walls, and the width of the carriage between the locking plates comprising: at each end, a first step (22, 22A) of width no greater than the distance L between the two locking plates less twice the diameter D of a floating peg; followed on each side of the carriage going axially towards the middle of the carriage by a second step (23, 23A) of width lying between L-2D and L-D; and finally by a middle step (24) of width less than L and greater than the width of the second step, with each transition between a first step and a second step taking place via a sloping wall.
Patent DE-3886656-T2 (DE)
Inventor: DE CASTIGLIONE ROBERTO
IPC: C07K7/06
Filed: 1988-10-06
Granted: 1994-04-28
Abstract: An octapeptide, endowed with thymic humoral activity, of formula (A)  H-Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu-OH      (A) and pharmaceutically acceptable salts thereof are prepared by condensing a compound of the formula (B):    X-Leu-G @u-A@p-Gly-Pro-K      (B) wherein X is an amino protecting group, Y and Y min  are each optional and each independently represents a carboxy protecting group and K is a hydroxy or hydrazido group, with a compound of formula (C)    H-L @s-Phe-Leu-Q      (C) wherein W is an amino protecting group and Q represents a carboxy protecting group or a hydroxy group; deprotecting the resultant compound of the formula (D)    X-Leu-G @u-A@p-Gly-Pro-L @s-Phe-Leu-Q      (D) wherein X,Y,Y min ,W and Q are as defined above; and, if desired, converting the resulting peptide of formula (A) into a pharmaceutically acceptable salt thereof.