baber/WOPTO huggingface dataset:
Patent ES-2189539-T3 (ES)
Title: Composiciones de revestimiento endurecibles que contienen mezclas de compuestos con funcionalidad de carbamato.
Inventor: OHRBOM WALTER
IPC: C09D169/00
Filed: 1999-10-21
Granted: 2003-07-01
Abstract: Composición de revestimiento endurecible que comprende: 5 (a) un componente seleccionado entre el grupo consistente en: **(Fórmula)** (1) un compuesto que tiene como mínimo un grupo carbamato o un grupo urea preparado mediante un paso consistente en someter a reacción una mezcla que comprende: (A) un compuesto que comprende un grupo carbamato o un grupo urea, o un grupo que se puede convertir en un grupo carbamato o un grupo urea, y un grupo que es reactivo con (a)(1), y (B) un poliisocianato, (2) un compuesto que tiene como mínimo un grupo carbamato o un grupo urea preparado mediante un paso consistente en someter a reacción una mezcla que comprende: (A) un compuesto que comprende un grupo carbamato o un grupo urea, o un grupo que se puede convertir en un grupo carbamato o un grupo urea, y un grupo isocianato, y (B) un compuesto que tiene como mínimo dos grupos reactivos con funcionalidad de isocianato, y mezclas de ellos; (b) un polímero acrílico que comprende grupos funcionales con contenido de hidrógeno activo que son reactivos con el componente (c), y (c) un agente endurecedor que es reactivo con los componentes (a) y (b), teniendo dicho grupo carbamato la siguiente estructura **(Fórmula)** en la que R es H o alquilo, y teniendo dicho grupo urea la siguiente estructura **(Fórmula)** en la que R¿ y R¿ son independientemente H o alquilo, o R¿ y R¿ forman conjuntamente una estructura de anillo heterocíclico.
Patent PL-1623094-T3 (PL)
Title: Controlled expansion of rock bolt
Inventor: PERSSON TOMMY
IPC: E21D20/00
Filed: 2004-05-12
Abstract: The present invention is related to a method for manual installation of rock bolts expandable by means of a pressure media comprising manual coupling of a pressure source to a rock bolt to be expanded. The method comprises the steps of an operator starting a sequence whereby the rock bolt is pressurized to a predetermined pressure, and it being ensured that the predetermined pressure is kept for a predetermined period of time. The present invention is also related to such a control system, and an apparatus comprising such a control system.
Patent PL-1641954-T3 (PL)
Title: Castable magnesium alloys
Inventor: LYON PAUL
IPC: C22C23/06
Filed: 2004-10-08
Abstract: This invention relates to magnesium-based alloys particularly suitable for casting applications where good mechanical properties at room and at elevated temperatures are required. The alloys contain: 2 to 4.5% by weight of neodymium; 0.2 to 7.0% of at least one rare earth metal of atomic No. 62 to 71; up to 1.3% by weight of zinc; and 0.2 to 0.7% by weight of zirconium; optionally with one or more other minor component. They are resistant to corrosion, show good age-hardening behaviour, and are also suitable for extrusion and wrought alloy applications.
Patent PL-1658386-T3 (PL)
Title: Gas quenching method using a recycling facility
Inventor: CHAFFOTTE FLORENT
IPC: C21D1/62
Filed: 2004-08-10
Abstract: After a quenching operation, all or part of the gas from the quenching cell (V1) passes to an intermediate storage tank (V3) by partial or complete pressure balance between the two volumes. The gas in the storage tank is then transferred through a compression or surpression group comprising one or more compressors/supressors in parallel (C1, C2..) to a balance capacity (V2) feeding the cell : Method of quenching in gas, where a quenching cell (V1) designed to receive objects to be quenched in a gas is connected to means of putting the cell under pressure. The means of putting the cell under pressure comprise a balance capacity (V2) containing the quenching gas. Part of the cell content is vented to atmosphere if necessary. The transfer from the intermediate storage tank to the balance capacity takes place while the quenching cell is immobile or while the parts for quenching are transferred. An inflatable capacity (V4) is placed to receive gas from the cell through a vacuum pump (P1). This is then disconnected from the vacuum pump and connected to the compression/surpression unit to which the gas is discharged.
Patent PL-1613598-T3 (PL)
Title: Methods of preparing aripiprazole crystalline forms
Inventor: ARONHIME JUDITH
IPC: C07D487/00
Filed: 2004-12-16
Abstract: The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.
Patent PL-1740286-T3 (PL)
Title: Screening grid
Inventor: GRAMMELSBERGER AXEL
IPC: E02B8/02
Filed: 2005-01-21
Abstract: A screening grid for discharging solids from a liquid flow. The grid includes a driveable screening strip that can be inserted into the liquid flow and includes two lateral link chains between which carrying rods extend, carrying groups of adjacent screening links. All screening links include projecting parts that extend respectively only in one direction from a group of screening grids, without being overlapped by the projecting parts of the adjacent group of screening links. All of the screening links of a group are provided with projecting hooks on the outer side of the screening strip.
Patent PL-1737692-T3 (PL)
Title: Method for producing a sealing or decorative strip, in particular, for a motor vehicle and said sealing or decorative strip
Inventor: HOCHHOLZER ECKEHARD
IPC: B60J10/04
Filed: 2005-04-19
Abstract: The invention relates to a method for producing a sealing or decorative strip, in particular, for a motor vehicle (10), said strip comprising a first component (20) and a second component (30) which are adjacent on the front side. Said method comprises the steps of a) extruding a first component (20), made of a first material, b) providing the first component (20) with an end section (21), having an upper side (22), a lower side (23) and a front side (24), c) providing the end section (21) with a cavity (25) which extends inside the first component (20) and opens on the front side (24), d) injection moulding the second component (30) by means of a moulding mass, made of a second material, whereby, during injection moulding, the first and second components are joined by a material fit on the front side and the moulding mass enters the cavity. Preferably, the first and second components are respectively embodied as a seal (20) and an end cap (30), terminating the seal (20) at the end section (21).
Patent PL-1789348-T3 (PL)
Title: Cigarette box and its blank
Inventor: MAZUR WOJCIECH
IPC: B65D85/10
Filed: 2005-07-14
Abstract: A cigarette box, of a rectangular prism shape, formed of a storage part adapted to accommodate cigarettes within and a hinged lid connected with the said storage part by means of an articulated joint placed on the rear wall. The front wall of the lid is longer than its rear wall, and the side walls are oblique. The storage part, is provided with an additional inside front wall (7) and the outside front wall (8) of the storage part is hinged. Between the hinged front wall (8) and the inside front wall (Z) there is an additional compartment useful for matches (9), lighters or other objects. The inside front wall (7) has two extrusion ridges (10, 11) oriented towards the box interior, where the lower extrusion ridge forms the storage space. The outside front wall is made of the same substance as the box and may feature an extrusion ridge (17) oriented towards the outside which would form an additional storage space.
Patent PL-1763534-T3 (PL)
Title: NOVEL 2-SUBSTITUTED D-HOMO-ESTRA-1,3,5(10)-TRIENES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1
Inventor: GEGE CHRISTIAN
IPC: A61K31/56
Filed: 2005-07-04
Abstract: The invention relates to novel 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) wherein R<SUP>2</SUP> represents a C<SUB>1</SUB>-C<SUB>8</SUB> alkyl, a C<SUB>1</SUB>-C<SUB>8</SUB> alkyloxy group or a halogen atom, R<SUP>13</SUP> represents a hydrogen atom or a methyl group, and R<SUP>17</SUP> represents a hydrogen atom or a fluorine atom. The invention also relates to the pharmaceutically acceptable salts of said compounds, to the production thereof, and to the use of the same as medicaments for the prophylaxis and treatment of oestrogen-dependent diseases that can be influenced by the inhibition of 17ß-hydroxysteroid dehydrogenase type 1.
Patent PL-1743856-T3 (PL)
Title: Device and method for transporting a stream of articles and device for filling a subsequent device with rod-like articles
Inventor: KRÖSSMANN JÜRGEN
IPC: B65G47/51
Filed: 2006-07-14
Abstract: The device has an endless conveying element (32) with a transport device (33) and a recirculating device (34). The transport device can be inversely brought from a flow position, in which the transport device has maximum length, in the discharge position, in which the maximum length of the transport device is shortened. Independent claims are also included for the following: (A) a device for filling; and (B) a method for transporting materials.
Patent PL-1934208-T3 (PL)
Title: Novel polymorphous form of 5-chloro-n-({ (5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
Inventor: GRUNENBERG ALFONS
IPC: C07D413/14
Filed: 2006-09-22
Abstract: The present invention relates to a novel polymorphic form and the amorphous form of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene-carboxamide, processes for their preparation, medicaments comprising these forms, and their use in the control of diseases.
Patent PL-1981504-T3 (PL)
Title: Thiadiazole derivatives for the treatment of neuro degenerative diseases
Inventor: GRIFFIOEN GERARD
IPC: C07D285/12
Filed: 2007-02-07
Abstract: This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an a-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.
Patent PL-1991534-T3 (PL)
Title: Process for the preparation of 2-(4-hydroxy-3-morfolynil)-2-cyclohexenone
Inventor: NAPOLITANO ELIO
IPC: C07D265/30
Filed: 2007-02-12
Abstract: It is disclosed a process for the preparation of 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone (BTG-1675A) comprising the steps of: i) reacting N-hydroxymorpholine with cycloesanone in the presence of an oxidation agent thus obtaining an isoxazolidine of Formula IV; and ii) converting the isoxazolidine of Formula IV into 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone. Advantageously, the oxidation agent of the step i) is selected from the group consisting of metal oxides, esters and amides of the azodicarboxylic acid and the step ii) of conversion is carried out by basic catalysis followed by trituration in an aromatic hydrocarbon, preferably toluene. The process disclosed allows to obtain BTG-1675A according to the invention in an amount of hundreds of grams and on an industrial scale. The invention further concerns a new process for preparing hydroxylamines, particularly N-hydroxymorpholine, which is used in the process for preparing BTG-1675A.
Patent PL-2091769-T3 (PL)
Title: Method for accurately assembling a hinge with a window glazing, hinge and window glazing equipped with the hinge
Inventor: LAMOUREUX LAURENT
IPC: B60J1/18
Filed: 2007-12-21
Abstract: The method involves positioning a glazed element (2) in a mounting device. A hinge (4) is positioned, with respect to the glazed element, on the mounting device through a rotation point (P0) such that the hinge is rotated around a compensation unit with respect to the point. The compensation unit is placed between a wing (22) and the glazed element, where the wing is moved with respect to a fixation tab. The hinge is fixed to the glazed element. Independent claims are also included for the following: (1) a pane comprising a glazed element (2) an installation for assembling a glazed element and a hinge.
Patent PL-2143663-T3 (PL)
Title: Package for smoking articles
Inventor: NOVAK SLAVOMIR
IPC: B65D85/10
Filed: 2008-07-11
Abstract: A package for smoking articles comprises an outer shell (4) and an inner shell (2). The outer shell (4) has two major lateral walls (20) opposite to each other, as well as a top wall (24), a rear wall (22) and a bottom wall connecting the lateral walls (20). The inner shell (2) is mounted in the outer shell (4) for pivotal movement relative to the outer shell (4) between a closed position, in which the interior of the inner shell (2) is not accessible, and an open position, in which the interior of the inner shell (2) is at least partially accessible and in which the inner shell (2) partially protrudes between front edges (32) of the lateral walls (20). The outer shell (4) comprises an inner panel (30) positioned between the inner side of one of the lateral walls (20) and the inner shell (2), the inner panel (30) being provided with at least one cutout (34), preferably a slot. The inner shell (2) comprises a protruding tab (18) which is adapted to interact with the at least one cutout (34) during movement of the inner shell (2) to produce a noise.
Patent PL-2161211-T3 (PL)
Title: Bag with handle and method of manufacture thereof
Inventor: HUTCHISON BRIAN GEORGE
IPC: B65D75/56
Filed: 2009-03-30
Abstract: A bag includes a panel (20) having an inner surface (40) and an outer surface (32) and holes (34) through the panel. A handle strip (30) having a handle part (28) is disposed adjacent the panel outer face (32), and a reinforcing strip (36,44), which can be separate from or an extension to the handle strip (30), is disposed adjacent the panel inner face (40). Areas of the reinforcing strip (36,44) are sealed to areas of the handle strip at the holes (34) and are sealed also to the inner face (40) of the panel. In a method of manufacturing the bag and handle arrangement, holes are formed in web for a bag panel, a handle strip has its end regions threaded through the holes and the end regions are folded back and sealed against each other and against a reverse surface of the web.
Patent PL-2233732-T3 (PL)
Title: Starter device for an internal combustion engine, in particular of an automobile
Inventor: LABBE NICOLAS
IPC: F02N15/06
Filed: 2010-03-22
Abstract: The device has a starter drive assembly for starting a combustion engine through a toothed crown wheel. An electrical motor rotatably drives the drive assembly. The motor has a stator (3) comprising an inductor winding (5) formed by a set of coils, where one of the coils presents low electrical resistance and another coil presents high electrical resistance. A set of contactors (55) of the motor controls power supply of a portion of shunt coils (51, 52) before controlling the power supply of all coils of the inductor winding. An independent claim is also included for a method for starting a combustion engine of a motor vehicle.
Patent GR-3004086-T3 (GR)
IPC: C07C29/14
Filed: 1992-03-19
Abstract: Process for preparing unsaturated alcohols by hydrogenation in a homogeneous medium of the corresponding unsaturated carbonyl compounds in the presence of a catalyst chosen from among ruthenium hydrides and derivatives complexed with a ligand or associated with a ligand.
Patent GR-3005338-T3 (GR)
IPC: A61K31/195
Filed: 1992-08-04
Abstract: Tertiary butyl esters for use an anticancer drugs have the formula:   <CHEM> wherein R1 and R2 are the same or are different and each is H, Cl, F, Br or I, and R2 may also be NH2; R3, R4 and R5 are the same or are different and each is H, F, Cl, Br or I or C1-C3 alkyl which may be substituted with F, Cl, Br, or I; with the proviso that at least two of R3, R4, and R5 are alkyl or substituted alkyl; and  n is an integer of 0-4. The compounds can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.
Patent GR-3005716-T3 (GR)
IPC: C12Q1/6883
Filed: 1992-09-17
Abstract: Method to distinguish between individuals who have normal metabolisms and gain weight due to overeating from those individuals who have a propensity to gain weight due to a genetic abnormality by detecting the level of the protein adipsin in the blood or the level of adipsin DNA in leukocytes. Method for treating genetic weight gain abnormality by administering therapeutic amounts of adipsin.
Patent GR-3006579-T3 (GR)
IPC: C07J13/00
Filed: 1992-12-18
Abstract: 17-Halogenomethylene-oestratrienes of the general formula I 
<IMAGE>
 in which R1 is a hydrogen atom, a methyl or acyl group and R2 is a halogen atom. 
<??>The compounds have low affinity for the oestrogen receptor and bring about an increase, compared with oestradiol, in cell membrane and blood/lymph vessel permeability.
Patent GR-3017893-T3 (GR)
Title: Siringe-like device for dosing fluids or pastes.
Inventor: DIEDERICH REINER DIPL-ING
IPC: A61C19/06
Filed: 1995-10-26
Abstract: A fluid can advantageously be dosed with a syringe-like device from a container (18) fixed thereon by means of a piston (3) displaceably mounted in a dosing chamber (2), this dosing chamber (2) being connected with the container (18) via a channel (8) penetrating this piston (3), a valve (11) and a channel (16) located together with the piston (3) in a connecting tube (10). <IMAGE>
Patent GR-3020251-T3 (GR)
Title: Wood preservative agent.
Inventor: GOETTSCHE REIMER DR
IPC: B27K3/52
Filed: 1996-06-18
Abstract: Wood preservative containing a copper compound, an alkanol amine and a phosphonium compound, and process for preserving wood using this wood preservative.
Patent GR-3020853-T3 (GR)
Title: Macrocyclic lactam prokinetic agents
Inventor: FREIBERG LESLIE A
IPC: A61K31/70
Filed: 1996-08-22
Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I)   ts thereof, wherein A is selected from    <IMAGE>  (II)   <IMAGE>  (III)  and   <IMAGE>  (IV)  also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.
Patent GR-3021019-T3 (GR)
Title: Magnetic force-transmitting device.
Inventor: SCHROETTER JOHANNES
IPC: H02K49/10
Filed: 1996-09-12
Abstract: A magnetic force-transmitting device has at least two substantially roller-shaped bodies (12, 14) rotatively mounted next to each other. Magnetic spirals (18, 20) are arranged in the circumferential area of the rollers in such a way that like poles point outwards.
Patent GR-3025330-T3 (GR)
Title: Variants of pai-2
Inventor: GOSS NEIL HOWARD
IPC: C07K19/00
Filed: 1997-11-11
Abstract: PCT No. PCT/AU90/00603 Sec. 371 Date Oct. 11, 1991 Sec. 102(e) Date Oct. 11, 1991 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/09124 PCT Pub. Date Jun. 27, 1991.Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described.
Patent GR-3030277-T3 (GR)
Title: Dihydropyridazinones and pyridazinones as fungicides
Inventor: EGAN ANNE RITCHIE
IPC: C07D237/26
Filed: 1999-05-27
Abstract: This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula <CHEM>  wherein     A is        -(CHR<2>)n-CHR<7>-Z-;        -(CHR<2>)n-O-Z-;        -(CHR<2>)n-S-Z-;        -O-CHR<7>-Z-;        -CR<2>=CR<7>-Z-;        -CR<2>=N-Z-;        CHR<2>-CR<7>=Y-; or        -CR<2>=CR<2>-Y=;     D is CR<2> or nitrogen;     Q is <CHEM>   <CHEM>   <CHEM>   <CHEM>   <CHEM>   <CHEM>     Z is carbonyl (C=O) or thiocarbonyl (C=S); Y is carbon substituted with halo, alkoxy, alkynylthio or triazolyl;h nd either   (i) R<1> is alkyl, hydroxyalkyl, cyanoalkyl, hydrazidal and derivatives thereof, cycloalkylalkyl, heterocyclylalkyl, phenyl, phenylalkyl, phenylcarbonyl, alkenyl, haloalkenyl, phenylalkenyl, alkynylalkenyl, alkynyl, haloalkynyl, phenylalkynyl, heterocyclyl, dialkynyl, heterocyclylalkynyl, cycloalkylalkynyl, alkenylalkynyl, hydroxyalkynyl, alkoxyalkynyl, alkanoyloxyalkynyl, formylalkynyl, trialkylsilylalkynyl, trialkyltinalkynyl, haloalkenylalkynyl, carboxyalkynyl, or alkoxy-carbonylalkynyl;     R<2> is hydrogen, (C1-C3)alkyl, phenyl, or halogen; R<7> is hydrogen, (C1-C3)alkyl, phenyl, halogen, alkynylalkenyl, alkynyl, dialkynyl, haloalkynyl, or alkenylalkynyl;     R<3> and R<6> are independently hydrogen, alkoxy or halogen;     R<4> is hydrogen, halogen, alkoxy or nitro; and R<5> is hydrogen, halogen, nitro, alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, haloalkylthio, phenyl, phenoxy or cyano;  or alternatively (ii) R<2> and R<3> together form a (C1-C3)alkyl, (C2-C3)alkylene or carbonyl link and R<1>, R<4>, R<5>, R<6> and R<7> are as above;  or alternatively (iii) R<2> and R<7> together form a fused phenyl ring and R<1>, R<3>, R<4>, R<5> and R<6> are as above; and agronomically acceptable salts thereof; compositions containing these compounds and methods of controlling fungal diseases.
Patent GR-3031111-T3 (GR)
Title: Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them.
Inventor: SCHWARK JAN-ROBERT DR
IPC: C07D213/30
Filed: 1999-08-31
Abstract: There are described benzoylguanidines of the formula I <IMAGE>  in which:     R(1) is R(6)-CO or R(7)R(8)N-CO, where R(6), R(7) and R(8) are (perfluoro)alk(en)yl, -(CH)2n-R(9), R(9) is cycloalkyl, phenyl, biphenylyl or naphthyl, where R(7) and R(8) can together be 4 or 5 methylene groups, of which one CH2 group can be replaced by oxygen, S, NH, N-CH3 or N-benzyl; R(2) is defined as R(1), or is H, Hal, CN, NO2, (perfluoro)alk(en)yl, -(CH)2 R(15) where  R(15) is cycloalkyl, phenyl, biphenylyl or naphthyl, or   R(2) is (C1-C9)-heteroaryl, or   R(2) is SR(18), -OR(18), -NR(18)R(19), -CR(18)R(19)R(20);  R(18) = -(CH2)-heteroaryl,  R(19), R(20) are defined as R(18) or are H, (perfluoro)-alkyl, or   R(2) is R(21)-SOm or R(22)R(23)N-SO2-, where R(21) is (perfluoro)alk(en)yl, -CH2-R(24), R(24) is cycloalkyl, phenyl, biphenylyl or naphthyl,  R(22) is H, (perfluoro)alk(en)yl, -(CH2)n-R(29),  R(29) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,  R(23) is H, (perfluoro)alkyl, where R(22) and R(23) can together be 4 or 5 methylene groups, of which one CH2 group can be replaced by oxygen, S, NH, N-CH3 or N-benzyl; or   R(33)X-, where R(2) is  X is oxygen, S, NR(34), (D=O)A-, NR(34)C=MN<(*)>R(35)-, where  M is oxygen, S,  A = oxygen, NR(34),  D = C, SO R(33) and R(35) are (perfluoro)alk(en)yl, -(CH2)n-R(36), where R(36) is cycloalkyl, phenyl, biphenylyl or naphthyl,  R(34) = H, (perfluoro)alkyl, where A and N<(*)> are bonded to the phenyl ring of the benzoylguanidine parent structure; or   R(2) is -SR(40), -OR(40), -NHR(40)R(41), -CHR(40)R(42), <IMAGE>  -C=CR(45) <IMAGE>  where R(40), R(41) are identical or different, and are  -(CH2)p-(CHOH)q-(CH2)r-(CHOH)t-R(51) or  -(CH2)p-O-(CH2-CH2O)q-R(51),  R(51) is hydrogen or methyl, R(42), R(43) are hydrogen or alkyl or, together with the carbon atom carrying them, form a (C3-C8)-cycloalkyl; R(44) is H, (C1-C6)-alkyl, (C3-C8)-cycloalkyl, -CeH2e-R(45) where R(45) is phenyl, heteroaryl or alkyl,  R(46), R(47), R(48), R(49) and R(50) are hydrogen or methyl; or   R(2) is R(55)-NH-SO2-, R(3), R(4) and R(5) are independently of one another defined as R(1) or R(2); and their pharmaceutically tolerable salts.0