baber/WOPTO huggingface dataset:
Patent AP-1544-A (AP)
Title: Broadspectrum 2- (substituted-amino) -benzoxazole sulfonamide HIV protease inhibitors.
Inventor: SURLERAUX DOMINIQUE LOUIS NESTOR GHISLAIN
IPC: C07D493/04
Filed: 2002-04-09
Granted: 2006-01-12
Abstract: The present invention concerns the compounds having the formula (I) N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted Cl-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Hetl, Het2; Rl may also be a radical of formula (RIlaRllb)NC(R10aR10b)CR9-; t is 0,1 or 2; R2 is H or Cl-6alkyl; L is -C(=O)-, -O-C(=O)-, -NR8-Q=O)-, -O-Cl-6alkanediyl-C(=O)-, -NR8-Cl-6alkanediyl-C(=O-, -S(=O)2-, -O-S(=O)2-, -NR8-S(=O)2 ; R3 is Cl-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylCl-4alkyl, or arylCl-4alkyl; R4 is H, Cl-4.alkylOC(=O), carboxyl, aminoC(=O), mono- or di(Cl-4alkyl)aminoC(=O), C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted Cl-6alkyl; A is Cl-6alkanediyl, -C(=O, -C(=S)-, -S(=O)2-, Cl-6alkanediyl-C(=O)-, Cl-6alkanediyl-C(=S)- or Cl-6alkanediyl-S(=O)2-; R5 is H, OH, Cl-6alkyl, HetlCl-6alkyl, Het2Cl-6alkyl, optionally substituted aminoCl-6aIkyl; R6 is Cl-6alkylO, Hetl, HetlO, Het2, Het2O, aryl, arylO, Cl-6alkyloxcarbonylamino or amino; and in case -A- is other than Cl-6alkanediyl then R6 may also be Cl-6alkyl, HetlCl-4alkyl, HetlOCl-4alkyl, Het2Cl-4alkyl, Het2OCl-4alkyl, arylC1-4alkyl, arylOCl-4alkyl or aminoCl-4alkyl; whereby each of the amino groups in the definition of R6 may optionally be substituted; -A-R6 is hydroxyCl-6alkyl; R5 and -A-R6 taken together with the nitrogen atom to which they are attached may also form Hetl or Het2. It further relates to their use as broadspectrum HTV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.
Patent DO-P2010000004-A (DO)
Title: Formulaciones estables de derivado de tiadiazol
Inventor: MISHRA DINESH SHYAMDEO
Filed: 2010-01-07
Abstract: La presente invención se refiere parametros de formulación y condiciones de manufacturación para composiciones farmaceuticas estables que comprenden N-{4 (2,2-dimetil-propionil)-(5R)-5-[(2-etilamino-etansulfonilamino)-metil]-5-fenil-4,5-dihidro-[1,3,4]tiadiazol-2-il}-2,2-dimetil-propionamida que minimiza la conversión quiral estable a la forma enantiomerica S menos activa.
Patent DO-P2010000089-A (DO)
Title: Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas
Inventor: CLAUSS ANNIE
IPC: C07D403/04
Filed: 2010-03-22
Abstract: La presente invención tiene por objeto los compuestos de formula (I) en el estado de base, de hidrato, de solvato, o de sus mezclas. La invención se refiere igualmente al procedimiento de preparación así como a las utilizaciones en terapéutica de los compuestos de formula (I)
Patent DO-P2012000178-A (DO)
Title: Cavidad cilindrica para hornos de uso domestico
Inventor: NUNEZ MIGUEL
Filed: 2012-06-21
Abstract: La presente invención consiste en una cavidad cilíndrica que conforma el interior de hornos a gas o eléctrìcos para uso domestico permitiendo que los hornos que utilizan esta cavidad cilíndrica optimizan la eriergía calórica transmitida por convección logrando calentar más rápído y cocinar alimentos en menor tiempo que los hornos de sección cuadrada, presentando un ahorro de hasta el 29% de Ia energía consumida en el proceso de cocción.
Patent DO-P2013000142-A (DO)
Title: Derivados de biciclo[3,2,1]octilamida y sus usos.
Inventor: LI GUIYING
IPC: A01N29/04
Filed: 2013-06-19
Abstract: La presente invención proporciona derivados de biciclo[3,2,1]octilamida de la fórmula (I): ; en donde L, R1 y R2 son tal como se definen en la presente o una de sus sales farmacéuticamente aceptables; y composiciones farmacéuticas y sus métodos de uso.
Patent EC-SP10010232-A (EC)
Title: Sistema de alimentación para una carga inductiva a partir de una fuente de energía con potencia variable
Inventor: PASTORI AURELIO ANTONIO
Filed: 2010-06-04
Abstract: La presenta invención se refiere a un sistema para alimentación de una carga inductiva (P5), con energía eléctrica de corriente continua, generada a partir de una fuente de energía (2) y, más en particular, a un sistema de alimentación para una bomba vibratoria (P5) a partir de energía solar o eólica (2), el cual procesa la energía eléctrica de corriente continua suministrada por el banco de células solares o generador eólico (2), de forma compatible, utilizando un circuito electrónico de comando por microcontrolador digital (20), para el control y accionamiento de bomba vibratoria (P5), independiente de las variaciones de la energía eléctrica suministrada por las fuentes como células solares, debido a las alteraciones en el nivel de radiación solar; o en generador eólico, debido a las variaciones de la velocidad del viento.
Patent EC-SP12011928-A (EC)
Title: Vacuna de adn contra el virus de la fiebre amarilla
Inventor: MARQUES ERNESTO TORRES DE AZEVEDO
IPC: C12N15/40
Filed: 2012-05-28
Abstract: La presente invención se refiere a vacunas de ADN que codifican para secuencias virales específicas. Las vacunas de ADN contra la fiebre amarilla, desarrolladas según la invención, se basan en la secuencia que codifica para la proteína de la envuelta de VFA (p/YFE). Además de la construcción de tipo natural p/YFE, la secuencia E también se fusionó con la secuencia que codifica para la proteína asociada a la membrana humana lisosómica (h-LAMP), generando la construcción (pL/YFE). Los resultados de la invención se consideran muy prometedores puesto que las dos construcciones pueden inducir una respuesta de células T contra los mismos epítopos inducidos por la vacuna 17DD, y la construcción pL/YFE también podía inducir anticuerpos neutralizantes a una concentración considerada satisfactoria. El vector pL/YFE también se inoculó en ratones para la exposición intracerebral posterior con VFA. Sorprendentemente, el 100% de los ratones inmunizados con pL/YFE sobrevivieron a la exposición.
Patent EE-200200468-A (EE)
Inventor: AEFFERDEN BAUDOUIN VICOMTE VAN
IPC: A23L13/40
Filed: 2001-02-22
Abstract: The invention relates to a seasoning mixture containing a liquefiable fat for the food industry with a salt content from about 15 to 67 wt %, relative to the weight of the seasoning mixture, or a seasoning mixture with a salt content from about 15 to 67 wt %, relative to the weight of the seasoning mixture, wherein the liquefiable agent is selected from the group consisting of hydrocolloids, gelatine, emulsifiers and carbohydrates, wherein, after the seasoning mixture has been applied to the article to be seasoned, an even, solid layer is formed on the latter as said seasoning mixture solidifies.
Patent EE-200300201-A (EE)
Inventor: CHEN SHIRLYNN
IPC: A61K31/37
Filed: 2001-10-30
Abstract: A microemulsion of pyranone protease inhibitor compounds that is substantially free of alcohol and propylene glycol comprising a pyranone protease inhibitor, one or more pharmaceutically acceptable surfactants, and a polyethylene glycol solvent having a mean molecular weight of greater than 300 but lower than 600, and a lipophilic component comprising medium chain mono- and di-glycerides, and optionally a basic amine.
Patent GB-189703945-A (GB)
Title: An Improved Thread, and Method of Making same.
Inventor: CLARK WILLIAM
Filed: 1897-02-13
Granted: 1897-03-27
Abstract: 3945. Clark, W. Feb. 13. Yarns and threads. -In the manufacture of thread for machine sewing &c. the individual strands forming the thread are given a much harder twist than usual, while in a wet or damp condition, before being combined together into a thread. The number of turns per inch given to the strands is preferably about seven or eight times the square root of the number representing the count of the yarn. The invention is specially applicable to the manufacture of three-cord thread.
Patent GB-189708595-A (GB)
Title: Improvements in Steam Generators.
Inventor: PALMER THOMAS CASSIENET
Filed: 1897-04-03
Granted: 1898-02-05
Abstract: 8595. Palmer, T. C. April 3. Water-tube boilers.-In the arrangement shown in Fig. 1, water chambers f, g are connected by concentric rows of tubes d around which the gases from the firebox b circulate. The outermost row of tubes form a closed wall except at the firebox and smoke-box ends, where they are curved to allow of the passage of the gases. A central tube e of large diameter also joins the water chambers. A steam superheating coil surrounds the central tube. A vertical boiler is also described, in which the water-tubes are not straight and do not in general form a closed wall.
Patent GB-189720009-A (GB)
Title: Improvements in Grinding and Polishing Machines.
Inventor: RUDOLPHI FRANK
Filed: 1897-08-31
Granted: 1897-10-02
Abstract: 20,009. Rudolphi, F. Aug. 31. Surfacing and polishing metal &c., disc and wheel apparatus for. The work table C is mounted near each end upon parallel swinging arms E pivoted to the table and to the frame of the machine, and is provided with a handle F. Locking and limiting stops are provided.
Patent GB-189724977-A (GB)
Title: Ice-sledge.
Inventor: HENNIG ERNST ALFRED PAUL
Filed: 1897-10-28
Granted: 1898-10-15
Abstract: 24,977. Hennig, E. A. P. Oct. 28. Motor road vehicles. -Relates to ice-vehicles which may be propelled by the rider or by steam, electric, or other motive power. Fig. 1 shows a plan of the vehicle. A person seated on the saddle P propels the sledge by means of the cranks M, wheel V, pinion 0, bevel-wheels R, and screws S, the last of which cut into the ice. Chain or worm gearing may be substituted for that described, and the sledge may be propelled by a steam, electric, or other motor.
Patent GB-189807250-A (GB)
Title: Improvements relating to the Building Motions of Spinning and like Frames.
Filed: 1898-03-25
Granted: 1899-03-25
Abstract: 7250. Calvert, J., and Howard & Bullough. March 25. Building-motions.-Relates to building-motions for winding long lift bobbins with a square bottom and tapered top. The heart cam A is provided with a sliding extension or nose B which is gradually moved outwards as the cop is built up. The sliding bit or nose B may be connected by a screw D and the bevel gearing shown with a swivelling shaft or stud H, which is normally held stationary by friction &c., but which can be operated by a handle for withdrawing the bit or nose B and winding back the ring or lifter rail &c. Connected with the oscillating lever operated by the heart cam is a vertical tapered rod, and, as the rod rises and falls, the swivelling shaft H is moved against the action of the spring K so as to put the wheels G and F out of gear, or the wheels are allowed to engage with one another. When the wheels G, F are in gear, the wheel F is held stationary and the wheel E and screw D are rotated through being carried round with the cam A. The wheels G, F may also be placed in or out of gear at will by means of a sliding bush S, which is thick at one edge and thin in the middle and is operated by a sliding bar beneath. Instead of the bevel-wheels E, F<1>, an eccentric or cam on the wheel F may engage with a notch in the sliding bit or nose B.
Patent GB-189813965-A (GB)
Title: Improvements in and relating to the Treatment of Sandal-wood Oil for the Production of Santalol.
Inventor: STECHE CARL ALBERT
Filed: 1898-06-23
Granted: 1898-08-20
Abstract: 13,965. Steche, C. A., Steche, H., and Habenicht, T. June 23. Santalol.-East Indian sandalwood oil is mixed with an alcoholic solution of soda or potash. After standing or boiling, the product, freed from alcohol and alkali, is fractionally distilled with superheated steam or in vacuo to produce pure santalol.
Patent GB-189817517-A (GB)
Title: Improvements in Telegraph Apparatus.
Filed: 1898-08-13
Granted: 1899-07-01
Abstract: 17,517. Maiche (Limited), [Maiche, L.]. Aug. 13. Telegraphs. - Relates to receiving-relays and transmitting-apparatus especially for long distance signalling. The Figure shows the arrangements of the relay circuits, in which the pivoted coil B arranged in a magnetic field is connected to the line L. A second low-resistance coil K is wound on the same spool D, and is so connected up with the battery I that, on completion of the relay circuit under the action of the coil B, the coil K restores the relay to its normal position. E is a platinum rod connected to the spool D and arranged to make contact with a vertical surface of mercury in the open glass tube G. In the transmitting- apparatus an induction coil has its primary connected in a local circuit with the key and battery, the point between the battery and primary being earthed. The secondary coil is connected to line and earth through the primary.
Patent GB-189818082-A (GB)
Title: Improved Frame or Partition for Supporting Library Shelves and for like purposes.
Inventor: WINSLOW WILLIAM HERMAN
Filed: 1898-08-23
Granted: 1898-12-23
Abstract: 18,082. Winslow, W. H , and Winslow, r. A. Aug. 23. Book cases.-Relates to a frame for supporting library shelves. The uprights A, A', A<2>, A are constructed of central bars a and strengthened bars a<2>, a<2>, the lower ends being turned horizontally to form feet which are bolted to the floor. The horizontal members B, B', B<2> are tubular, and are held by rods b<1>, b<1> passing through them and through the uprights. Nuts b<2> tighten up the frame. To obtain still greater rigidity, tubular trusses Care used shaped as shown, and engaging pieces c, c' at the points of intersection of Band B' with A', and B<1> with A<2>. The trusses are tightened up by screws c<2>, c<2>.
Patent GB-189908366-A (GB)
Title: Improved Valve Attachment for Spraying or Squirting Bottles.
Inventor: URQUHART RIDLEY JAMES
Filed: 1899-04-21
Granted: 1899-06-02
Abstract: 8366. Urquhart, R. J., [Henning, G. F.]. April 21. Stoppers. - R e l a t e s to spraying or squirting bottles for volatile liquids, such as ethyl chloride. The capillary discharge orifice is formed in the side of the neck, where it protrudes through the perforated boss a on a flexible band or clip &c. A mounted on the neck, and is closed by the spring-controlled valve-lever C pivoted on the band &c.
Patent GB-189909369-A (GB)
Title: Improvements in High-speed Engines.
Inventor: BEVER AUGUSTUS
Filed: 1899-05-04
Granted: 1900-03-24
Abstract: 9369. Bever, A. May 4. High-speed engines; compound engines.-Relates to high-speed engines of the kind described in Specifications No. 1666, A.D. 1884, and No. 9039, A.D. 1886, and comprises arrangements of balanced engines with tandem compound cylinders disposed on opposite sides of the crank shaft and either with distributing-valves of the Corliss type or with piston valves ; also an engine with a single tandem pair of compound cylinders disposed vertically over the crank shaft. These engines may either have single-acting or double-acting cylinders, the former being designed to give a constant thrust. Fig. 1 shows one form of the invention in vertical section. In this the tandem cylinders A, B work on a three-throw crank shaft, one of the pairs of cylinders working on the two outer cranks through a forked connecting- rod. Steam acts constantly on the outer face of the high-pressure piston ; during the inward stroke steam is expanded from the inner side of the high-pressure piston to the outer side of the low-pressure piston, and during the outward stroke both the high-pressure and the low - pressure pistons are separately put in equilibrium. The final exhaust takes place at D. The distribution is effected jointly by the valve and by the highpressure piston working over the port m.
Patent GB-189912895-A (GB)
Title: Improvements relating to Self-propelled Road Vehicles.
Inventor: HALL ROBERT FREDERICK
Filed: 1899-06-21
Granted: 1899-11-04
Abstract: 12,895. Hall, R. F. June 21. Motor road vehicles. - Relates to a four-wheeled vehicle with a tubular or other skeleton u n d e rcarriage, on which a body of any suitable kind may be carried. The main object of the invention is to distribute the driving wear and tear equally over the whole system by making all the wheels act both as drivers and steerers. Further objects are to construct the vehicle of detachable parts, and to construct the undercarriage framing so that it can accommodate itself to unevenness in the road. Fig. 2 shows the undercarriage and driving-gear in plan. The frame is composed of two parts a and b, each constructed of tubes or bars and connected together so that one may swivel relatively to the other. Each is supported by one of the pairs of divided axles which run in fixed bearings on the frame. The motor is mounted on the front frame a, and drives a drum or flywheel pulley g<2> from which belts extend to two pairs of fast and loose pulleys on a shaft h near the rear axle. By the belt gear and by toothed gear, in casings f<2>, f<5>, the sleeve f<4> on the rear axle may be driven at one or other of two speeds ; the motion is thence transmitted to the divided axle by balance gear at f<6>. The sleeve f<4> is connected by a chain to a similar sleeve and balance gear on the front axle, which thereby is driven simultaneously with the rear axle. The wheels are each mounted in forks capable of swivelling in heads carried by lateral extensions of certain transverse members of the framing a<8>, b<8>. In order to provide for driving the wheels without hindering the swivelling, the wheel hubs and fork bearings are constructed as shown in Fig. 5. The wheel hub n' runs on a ball bearing at one side of the fork formed by cones n', n<8> carried by the hub and a ring n<2> attached to the fork. The splayed open end of the hub runs in a roller bearing in a ring m<11> attached to the other branch of the fork. The driving-axle e is connected to the wheel hub either by a universal joint o or by a form of Hooke's joint, the centre of which is in the axis about which the wheel swivels. The hub is closed at one side by a cap n<16>, and at the other by a flexible sleeve b. All the steering-wheels are coupled together, so as to move collectively, by rods connected to triangular arms capable of turning in steering-pillars s<1>, u<1>. The front and rear steering-spindles are connected together by means of levers and crossed flexible steel bands v<1>, v<2>, and are thereby simultaneously operated, when required, by a hand-wheel and rack and pinion gear at q, r.
Patent GB-189913956-A (GB)
Title: A New or Improved Window Cleaning Apparatus.
Inventor: KLEEMANN SAMUEL
Filed: 1899-07-06
Granted: 1899-08-19
Abstract: 13,956. Kleemann, S. July 6. Windows, cleaning.-Bars a, c, d, e, pivoted in each corner of the window, carry cleaning-pads on their inner surfaces. They may be connected to rotate together in pairs by means of chains and chain-wheels f. The bars are rotated to and fro through a right-angle by means of crank handles g secured on shafts h and having links k engaging slots l in the extensions of the bars.
Patent GB-189915653-A (GB)
Title: Automatic Take-up Regulators, applicable to Tulle and other Looms.
Inventor: PERRACHON JOSEPH ETIENNE
Filed: 1899-07-31
Granted: 1900-07-28
Abstract: 15,653. Perrachon, J. E. July 31. Tulle machines, take-up motions for. In tulle and other looms, the work beam M is driven at a speed gradually diminishing as the diameter of the work upon it increases. Two curved pallets a rest lightly upon the work, and gradually move a rod F horizontally by mtans of arms B, E on a shaft C. The rod F is connected to a vertical rod G, sliding in a pivoted socket at the base of the frame and having pins J, K to work respectively in a slotted pawlcarrier and a slotted link N. The link N is oscillated by a lever P, so that the traverse of the pawl is gradually reduced as the rod F shifts the pins along the slots from right to left. The ratchetwheels R actuate the work beam through worm gearing S, T. In a modification, the rod F has at one end a scale for adjustment, and at the other a wedge for controlling the amount of lift of the rod G.
Patent GB-189916459-A (GB)
Title: Improvements in Acetylene Gas Generators.
Inventor: PONCES JOSE
Filed: 1899-08-12
Granted: 1900-04-21
Abstract: 16,459. Ponces, J. Aug. 12. Acetylene. - In this generating - apparatus, a number of small generators f (twelve are given in the example described), are supplied with water from a corresponding number of overhead tanks, a different generator being put into use each time the gasometer bell falls. The bell k has an arm l<1> attached thereto, which supports, by means of a chain, a weight l, and is provided with a roller l<11>. As the bell falls, the weight rests upon a plate s', thereby operating a lever s, which releases a catch u<1>, allowing the lever t to fall by means of its weighted end t'. This results in the valve r being opened to allow water to pass from the corresponding water tank through a pipe j<1>, and discharge, by means of pipes v<1>, v, into a funnel i<1> on the top of a siphon i leading the water to the side of the generator casing f, within which the carbide basket e is supported on feet. All the generators are enclosed within an annular water jacket g. The evolved gas passes by a tube g<1>, enclosed in a water jacket g<11>, to an inclined annular elliptical conduit or condenser w common to all the gene- .rators. It then passes to a washer, and thence through a purifier to the gas holder k. As the bell rises, the roller l<11> travels between a double set of races or guides, corresponding to the generator in use, each set having two pivoted members. Each time the roller descends, it is automatically switched to the guides of the next generator, thereby not only giving the bell an angular motion, but also, when the bell has fallen sufficiently, operating the water supply of the next generator.
Patent GB-189924049-A (GB)
Title: Improvements in Intercommunication Telephone Systems.
Inventor: WILSON LANCELOT EDWARD
Filed: 1899-12-02
Granted: 1900-12-01
Abstract: 24,049. Wilson, L. E. Dec. 2. Telephone systems.-Relates to that class of direct-call systems in which the line from each station is branched to each of the other stations, the call being made by means of jacks or switches connected to the line wanted, the home jack or switch having the bell in circuit. Each station is provided with a magnet m. the double-contact armature c of which normally completes a shunt across the secondary s of the induction coil, but when excited by a call opens the shunt and closes the circuit of the primary p. Separate pairs of stations can converse on independent lines, but an interfering station cannot clear its magnet m as the batteries put to the common line would be opposed.
Patent GB-189924967-A (GB)
Title: An Improved Process for the Prevention of Incrustation in Boilers.
Inventor: GOTTLOB JACOB
Filed: 1899-12-16
Granted: 1900-01-13
Abstract: 24,967. Gottlob, J. Dec. 16. Incrustation, preventing.-A series of electrodes connected with the positive pole of a battery are arranged within a boiler so as to dip into the water. The negative pole of the battery is connected with the shell of the boiler. The electrodes are preferably in the form of plates of zinc suspended from a wire h supported on pillars as shown. The connecting-wire passes through a steam-tight insulating-device consisting of a cylinder l of porcelain contained within a casing m which is screwed to the boiler shell. Washers of asbestos are placed above and below the cylinder. A plate u with a central projection as shown is screwed up against another washer within the boiler. The wire is held in place by nuts and asbestos washers contained in recesses as shown.