Patent SG-11201806976U-A (SG)
Title: Multigenome retroviral vector preparations and methods and systems for producing and using same
Inventor: TER MEULEN JAN
IPC: C12N15/86
Filed: 2017-02-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011101111101110111101111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/147119 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: BRUSCA, Eric, M. et al.; Marshall, Gerstein & C12N 15/86 (2006.01) A61K 39/00 (2006.01) Borun LLP, 233 S. Wacker Drive, 6300 Willis Tower, C12N 5/10 (2006.01) Chicago, IL 60606-6357 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/018823 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 22 February 2017 (22.02.2017) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/298,948 23 February 2016 (23.02.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/371,513 5 August 2016 (05.08.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 62/410,633 20 October 2016 (20.10.2016) US ZA, ZM, ZW. (71) Applicant: IMMUNE DESIGN CORP. [US/US]; 1616 (84) Designated States (unless otherwise indicated, for every Eastlake Ave E., Suite 310, Seattle, WA 98102 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: TER MEULEN, Jan, Henrik; 3842 West TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Mercer Way, Mercer Island, WA 98040 (US). BER- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, GLUND, Peter Lars, Aksel; 1616 Eastlake Ave E., Suite DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = 310, Seattle, WA 98102 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = [Continued on next page] Title: MULTIGENOME RETROVIRAL VECTOR PREPARATIONS AND METHODS AND SYSTEMS FOR PRODUCING (54) USING SAME AND (57) : The present invention provides novel multigenome = — Figure 1 retroviral vectors, methods and packaging systems for making such = retroviral vectors and methods of use. = One vector genome — one transgene = — = _ _ _ = = = One vector genome — two transgenes = = = = 11 Two vector genomes — two transgenes .4 C:r EZEN 0 0. 4 1 11 \"Reassoitant' 11 jo heterozygous IN A particle 7r 11 Multigenome viral particle Ir ... ' preparation 11 © N O WO 2017/147119 Al 1#11101M01101DEIROIDEOM0101111111101111111101110110111111 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))