Patent SG-11201906226Y-A (SG)
Title: Methods of treating bacterial infections
Inventor: LOUTIT JEFFREY
IPC: A61P13/02
Filed: 2018-01-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIPO I PCT mu °million °nolo Oil ommomomilioluo ois (10) International Publication Number WO 2018/129479 Al (51) International Patent Classification: A61K 31/407 (2006.01) A61P 13/12 (2006.01) A61K 31/69 (2006.01) A61P 31/04 (2006.01) A61P 13/02 (2006.01) (21) International Application Number: PCT/US2018/012839 (22) International Filing Date: 08 January 2018 (08.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/444,238 09 January 2017 (09.01.2017) US 62/513,936 01 June 2017 (01.06.2017) US (71) Applicant: REMPEX PHARMACEUTICALS, INC [US/US]; The Medicines Company, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). (72) Inventors: LOUTIT, Jeffrey, S.; The Medicines Compa- ny, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). DUDLEY, Michael, N.; The Medicines Company, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). MORGAN, Elizabeth, E.; The Medicines Compa- ny, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). FUSARO, Karen; The Medicines Company, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). GRIFFITH, David, C.; The Medicines Company, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). LOMOVSKAYA, Olga; The Medicines Company, 3033 Science Park Rd, 1st Floor, San Diego, CA 92121 (US). (74) Agent: ALTMAN, Daniel, E.; Knobbe, Martens, Olson & Bear LLP, 2040 Main Street 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) GO (54) Title: METHODS OF TREATING BACTERIAL INFECTIONS 1-1 0> (57) : Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) \" and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbactam in combi- C nation with meropenem are disclosed herewith.