Patent SG-11201807437X-A (SG)
Title: Antibodies specific to human poliovirus receptor (pvr)
Inventor: MANDELBOIM OFER
IPC: C07K16/28
Filed: 2017-02-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111010111111111110111011101111101111011111 International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2017/149538 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/1L2017/050256 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 28 February 2017 (28.02.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 62/301,727 1 March 2016 (01.03.2016) US 62/364,924 21 July 2016 (21.07.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: YISSUM RESEARCH DEVELOPMENT GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, COMPANY OF THE HEBREW UNIVERSITY OF TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, JERUSALEM LTD. [IL/IL]; Hi Tech Park, Edmond J. TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Safra Campus, Givat Ram P.O. Box 39135, 91390 Jerus- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, alem (IL). UNIVERSITY OF RIJEKA FACULTY OF LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, MEDICINE [HR/HR]; B. Branchetta 20, 51000 Rijeka, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Croatia (HR). GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventors: MANDELBOIM Ofer; 58 Hayarden St., Declarations under Rule 4.17: 6080858 Shoham (IL). KAYNAN, Noa S.; Kibbutz — of inventorship (Rule 4.17(N)) Barkai, 3786000 Kibbutz Barkai (IL). TSUKERMAN, Pinchas; 7/15 Hatzionut St., 9674111 Jerusalem (IL). Published: JONJIC, Stipan; Pogled 20, Marcelji, 51216 Viskovo — with international search report (Art. 21(3)) (HR). — with sequence listing part of description (Rule 5.2(a)) = (74) Agents: HORNIK, Vered et al.; WEBB & CO., P.O. Box 2189, 7612101 Rehovot (IL). 1-1 GC M kf) C:r 7r 11 IN 11 © (54) Title: ANTIBODIES SPECIFIC TO HUMAN POLIOVIRUS RECEPTOR (PVR) ei O (57) : The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its bind- ing to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical composi- tions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.