baber/WOPTO huggingface dataset:
Patent DK-2514823-T3 (DK)
Inventor: CASHMAN NEIL
IPC: G01N33/573
Filed: 2007-03-05
Granted: 2018-07-23
Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.
Patent DK-2714912-T3 (DK)
Inventor: VANDENBROUCKE KLAAS
IPC: C12R1/46
Filed: 2012-06-01
Granted: 2018-08-13
Abstract: The invention relates to polycistronic expression in gram-positive bacterium and in particular concerns polycistronic expression units comprising one or more gene endogenous to the gram-positive bacterium transcriptionally coupled to one or more genes exogenous to the bacterium.
Patent DK-2812024-T3 (DK)
Inventor: DAUGAARD MADS
IPC: C07K14/445
Filed: 2013-02-08
Granted: 2018-07-23
Abstract: The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).
Patent DK-2899168-T3 (DK)
Inventor: NAKANISHI TETSUYA
IPC: C03B37/027
Filed: 2013-09-24
Granted: 2018-03-12
Abstract: An optical fiber manufacturing method includes a drawing step and a slow cooling step. In the slow cooling step, an optical fiber passes through a heating furnace having a temperature which is set such that in at least 70% of a region from a first position at which a glass outer diameter of the optical fiber becomes less than 500% of a final outer diameter to a second position at which a temperature T of the optical fiber becomes 1400° C., an actual temperature of the optical fiber is within ±100° C. of a target temperature Tt(n) for each position n. The target temperature Tt(n) is a temperature at which a fictive temperature Tf(n+1) of a core at a position n+1 determined by calculation using the recurrence formula “Tf(n+1)=T(n)+(Tf(n)−T(n))exp(−Δt(T(n)))” starting from a fictive temperature Tf(0) of the optical fiber at the first position n=0 is lowest.
Patent DK-0379216-T3 (DK)
Inventor: KLEIN CHRISTIAN DR RER NAT
IPC: G01N33/532
Filed: 1990-01-19
Granted: 1994-10-31
Abstract: For the determination of immunologically detectable substances by the principle of the heterogeneous immunoassay by incubation with at least two receptors R1 and R2, of which R1 mediates the binding to the solid phase and R2 is a conjugate of a ligand which is able to bind to a substance to be determined and of a label, using a solid phase to which a reaction component capable of specific binding is bound, separation of the solids from the liquid phase and determination of the label in one of the two phases, the solid phase is a material to whose surface are bound partners capable of specific binding, and the sample solution is incubated with a plurality of different receptors R1, where each receptor R1 has both binding sites for the partner which is capable of specific binding and is bound to the solid phase and binding sites for one of the substances to be determined. <IMAGE>
Patent DK-0417700-T3 (DK)
Inventor: BORNSTEIN AHARON
IPC: G01N21/43
Filed: 1990-09-10
Granted: 1996-05-28
Abstract: Method of ATR spectroscopy and substrate probe for use therein. The probe comprises a single optical fibre sensor, a bundle of such sensors, the sensing zone of each sensor being a small diameter cylindrical portion merging at least on the side of the light intake end into a frustoconical portion whose large diameter base is turned away from said small diameter cylindrical portion.
Patent DK-0387059-T3 (DK)
Inventor: GIBBONS WAYNE MICHAEL
IPC: G11B7/25
Filed: 1990-03-08
Granted: 1999-03-29
Abstract: Disclosed is a process for aligning the molecules in a liquid crystal medium having a surface adjacent to a substrate, in which the liquid crystals have a molecular weight of less than 1500, and anisotropically absorbing molecules in the medium or in the substrate adjacent to it are exposed to linearly polarized light of a wavelength within the absorption band of the absorbing molecules, and alignment of the liquid crystal medium at an angle + or -  theta with respect to the direction of the linear polarization of the incident light beam is induced by the exposed anisotropically absorbing molecules.
Patent DK-0431798-T3 (DK)
Inventor: KOBAYASHI JUNICHI
IPC: B31D1/02
Filed: 1990-11-21
Granted: 1996-02-05
Abstract: A method of making labels for application to a product comprises assembling a backing web and a label web. The backing web is passed through a release material application station and a curing station for the release material, prior to assembly with the label web, and in the same machine. This enables pre-printing of the backing web so that portions of it can be used to display information or other matter instead of being wasted. Also, by treating both sides of the backing web, a label web can be applied to both sides of it, thereby enhancing economy of costs and materials.
Patent DK-0379405-T3 (DK)
Inventor: GROSHENS PIERRE
IPC: B05C1/08
Filed: 1990-01-12
Granted: 1993-11-15
Abstract: Method and apparatus for making a thermally adhesive textile-based product by hot coating using spots. 
<??>The thermally adhesive polymer is deposited in the form of spots onto a transfer belt by the photoengraving roll, these spots of thermally adhesive polymer then being brought into contact with the textile support so as to ensure their transfer onto the latter. 
<??>The apparatus comprises a nonadherent belt (5) ensuring the transfer of the spots (4) of thermally adhesive polymer from the photoengraving roll (2) towards the textile support (3). 
<IMAGE>
Patent DK-0444647-T3 (DK)
Inventor: HAND GEOFFREY
IPC: D06M101/16
Filed: 1991-02-27
Granted: 1995-09-04
Abstract: A flame retardant composition comprises at least one cyclic phosphonate ester and at least one phosphono amide. The ester and the amide are present in a ratio by weight of 0.1 to 2:1. A co-curing agent (e.g. urea, ethylene urea or an amino-triazine) may be included. The composition may also contain a non-rewetting agent and/or a softening or conditioning agent. The composition is used for the flame retardant treatment of a fabric by first impregnating the fabric with an aqueous solution of the composition and then heating the impregnated fabric at at least 100 DEG C and under acid pH conditions.
Patent DK-0491239-T3 (DK)
Inventor: HERRMANN WOLFGANG PROF DR DIPL
IPC: C07C45/50
Filed: 1991-12-05
Granted: 1995-07-03
Abstract: The hydroformylation of olefins and olefinically unsaturated compounds in the presence of a water-soluble rhodium complex compound which contains, as a ligand, at least one sulfonated diphosphine, and a catalyst therefor.
Patent DK-0466628-T3 (DK)
Inventor: BIANCHI MAURO
IPC: F16F3/04
Filed: 1991-07-03
Granted: 1995-05-15
Abstract: The object of the invention is a method of suspension. 
<??>It utilises a means of softening the interruption of the gradient and/or a means of adjusting the point of interruption of the gradient for each of the load variations of the vehicle. 
<??>The means of adjusting the point of interruption of the gradient for each of the load variations of the vehicle in that case where two springs are used (one a main support spring (R1), the other an auxiliary spring (R2) fitted in opposition), is a hydraulic ram (3) located as "interface" between the mobile part (17) of the suspension of the spring (R1) and the auxiliary spring (R2). 
<??>The method has applications particularly on motor vehicles. 
<IMAGE>
Patent DK-0464189-T3 (DK)
Inventor: KETTERER DIETER
IPC: B60R21/26
Filed: 1991-01-29
Granted: 1995-05-08
Abstract: The motor vehicle is provided with an air-bag (110) to protect the occupants in the event of a crash. The air-bag is folded to a compact shape and fitted in a recess in the hub of the steering wheel. The folded air-bag surrounds a vessel (2) which contains the gas, or means to produce a gas, with which the air-bag is inflated. The gas or means to produce the gas are so chosen that the air-bag is inflated to the required size and pressure irrespective of the ambient temperature. This may be achieved by adding chemicals to the gas in order to heat it if necessary.
Patent DK-0528931-T3 (DK)
Inventor: ADAIR JOHN ROBERT GEORGE ROAD
IPC: C07K16/00
Filed: 1991-04-29
Granted: 1999-04-19
Abstract: The present invention discloses humanized chimeric antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. Specifically, disclosed are humanized anti-ICAM-1 antibodies of the IgG1, IgG2, and IgG4 subtype. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.
Patent DK-0495047-T3 (DK)
Inventor: KANDLER RICHARD L
IPC: A61K38/16
Filed: 1991-07-24
Granted: 1995-12-27
Abstract: The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5  DEG C to 45  DEG C for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemolobin based solution cannot have greater than about 50 % of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15 %. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.
Patent DK-0525506-T3 (DK)
Inventor: LOOSEN PIERRE CAMILLE
IPC: C07C69/157
Filed: 1992-07-15
Granted: 1996-08-12
Abstract: A process for the  alpha -monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids with dialkyl carbonates in liquid phase, in the presence of bases at temperatures ranging from about 100 DEG C to about 270 DEG C.
Patent DK-0538754-T3 (DK)
Inventor: ZOELLER MARGOT
IPC: A61P37/06
Filed: 1992-10-17
Granted: 1998-03-30
Abstract: The present invention relates to the use of preparations of antibodies directed against vCD44 for immunosuppression.
Patent DK-0679075-T3 (DK)
Inventor: FETTO JOSEPH
IPC: A61B17/00
Filed: 1992-04-22
Granted: 2000-11-13
Abstract: A femoral component of a hip endoprosthesis includes a lateral supporting wedge designed to be supported by the proximal lateral femur when in use. The wedge can be an integral part of the material of the femoral component or it can be placed on a standard component by cementing or preferably by a male/female socket fit. The lateral surface of the wedge forms an angle of about 10 DEG -20 DEG  with the midline of the distal portion of the stem and has an anterior-posterior width of about 8.30 mm, preferably about 10-20 mm, and a medial-lateral extension of the lateral surface of the stem of at least 10 mm, preferably 10-30 mm. An apparatus for testing the endurance of femoral components includes a cable corresponding to the ilio-tibial band. Such an apparatus more accurately models hip biomechanics and thus permits a more accurate test of the stresses on femoral component designs.
Patent DK-0621022-T3 (DK)
Inventor: FREEMAN JERRE M DR
IPC: A61B17/12
Filed: 1993-04-22
Granted: 1999-11-29
Abstract: The invention relates to a lacrimal fluid control device (20) for blocking the flow of lacrimal fluid from the surface of an eye through a punctal opening and into an associated canaliculus, said lacrimal fluid control device (20) comprises a tip portion (22) comprising a generally inverted truncated cone and being operable to facilitate placement of the lacrimal fluid control device at least partially through a punctal opening of a wearer and into a generally vertical portion of an associated canaliculus; a head portion (24) comprising a generally enlarged dome and being operable to prevent drift of the lacrimal fluid control device completely through the punctal opening and into the generally vertical portion of the associated canaliculus; a shank portion (26) integrally joined at one end to said head portion (24) and at the other end to said tip portion (22), said shank portion (26) interconnecting said head (24) and tip (22) portions and being operably engaged about its periphery by a punctal opening ring of tissue of a patient, said shank portion having, a diameter (28) adjacent to said head portion (24) which is less than the diameter (38) of said shank portion adjacent to said tip portion (22). <IMAGE>
Patent DK-0588500-T3 (DK)
Inventor: OKA MAKOTO
IPC: C07D471/04
Filed: 1993-08-18
Granted: 1999-07-19
Abstract: A 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I): <CHEM> wherein Het is an oxadiazole ring, R1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: -CH2R1' (in which R1' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, is useful as benzodiazepine receptor agonist.
Patent DK-0653207-T3 (DK)
Inventor: KONDO SHINICHI
IPC: A61P31/12
Filed: 1992-12-25
Granted: 1998-05-11
Abstract: D- beta -Lysylmethanediamine represented by formula (I) or a salt or hydrate thereof has an activity of inhibiting the infection with AIDS virus or HIV, and hence an AIDS virus infection inhibitor containing the same as an active ingredient is prospective as one of the remedies for AIDS which is thought to be difficult to cure. <CHEM>
Patent DK-0654991-T3 (DK)
Inventor: SIMPKIN GORDON THOMAS
IPC: A61K/
Filed: 1993-08-13
Granted: 1997-12-29
Abstract: A powder composition for inhalation comprising at least one microfine drug and a carrier, in which at least a portion of the said carrier comprises an antistatic agent.
Patent DK-0615532-T3 (DK)
Inventor: GRUBER PATRICK RICHARD
IPC: D04H1/42
Filed: 1993-09-30
Granted: 2000-10-16
Abstract: A lactide polymer coating resulting in a strong, repulpable, high gloss, paper coating. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 5 percent and water in concentration of less than about 2000 parts-per-million. A process for coating paper with the lactide polymer composition is also disclosed.
Patent DK-0633317-T3 (DK)
Inventor: ATANASSOVA ROSSITZA
IPC: C12R1/01
Filed: 1994-06-23
Granted: 2005-05-30
Abstract: 1) Chimeric gene for plant transformation. 2) It comprises at least, in the direction of transcription, a promoter region, a transgene and a termination region, characterised in that the termination region consists of at least one termination region of a plant histone gene which permits the expression of the protein in the regions of rapid growth. 3) Production of transgenic plants.
Patent DK-0708648-T3 (DK)
Inventor: AGGARWAL BHARAT B
IPC: A61P29/00
Filed: 1994-05-05
Granted: 2003-03-03
Abstract: Retinoic acid for inhibiting production of nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of nitric acid i.e. systemic lupus erythematosus or multiple sclerosis The most preferred retinoic acid is all-trans-retinoic acid. <IMAGE>
Patent DK-0714351-T3 (DK)
Inventor: WU PAI-CHUAN
IPC: B29C48/08
Filed: 1994-08-03
Granted: 1999-08-23
Abstract: An elastic laminated sheet of an incrementally stretched nonwoven fibrous web and elastomeric film and method of making are disclosed. The elastic laminates are especially useful in diapers, surgical gowns, sheets, dressings, hygienic products and the like.
Patent DK-0720655-T3 (DK)
Inventor: BALKENHOHL FRIEDHELM
IPC: C12R1/38
Filed: 1994-09-16
Granted: 2000-04-10
Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.
Patent DK-0695755-T3 (DK)
Inventor: BROKA CHRIS ALLEN
IPC: C07D209/86
Filed: 1995-07-21
Granted: 1999-06-28
Abstract: Compounds represented by the Formula I: <CHEM>  wherein:     R<1> is hydrogen or lower alkyl;     R<2> is heteroaryl; and     R<3> and R<4> are independently hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof, are useful as chemotherapeutic agents.
Patent DK-0739021-T3 (DK)
Inventor: HAAS HANS
IPC: H01H50/64
Filed: 1996-02-01
Granted: 2003-06-10
Abstract: The relay incorporates a contact bridge carrier (6), a thermoplastic intermediate plate (8), an armature (9) and a coupler (10) together with two pairs of elastic beams (14,15) forming a resilient connection between the contact bridge carrier and armature. The coupler is a bolt inserted into a hole (19) at right angles to the direction of movement of the armature. The intermediate plate has lateral projections (20) on both sides for guidance of the contact bridge carrier into the housing. These serve also as points of application of the drive for an auxiliary switch (not depicted).
Patent DK-0780096-T3 (DK)
Inventor: BOUTET ROBERT-LOUIS
IPC: A61B17/88
Filed: 1996-12-20
Granted: 2000-10-30
Abstract: The strap consists of a flat strip (1) fixed at one end to a clasp (2) and having a needle on its other end. The clasp has a rectangular section channel through it between lower (5) and upper (6) walls, and the upper wall is cut out to form vertical lugs (3) which can be bent over on top of the strip. The strip is fastened to the clasp by being passed round it in at least one turn, forming at least one outer layer and two inner layers, and leaving sufficient space in the channel for the free end of the strip to be passed through after the needle has been removed. The strap can be tensioned by a clamp with a sloping surface and lever before fixing. Both strip and clasp are made from a biocompatible material such as stainless steel.
Patent DK-0868316-T3 (DK)
Inventor: CLAES IVO JOANNA HUBERT
IPC: B60B21/06
Filed: 1996-01-12
Granted: 2002-04-15
Abstract: A bicycle wheel rim can be worn down by rim brakes, leading to serious accidents. The present invention relates to a novel bicycle rim that provides direct and clear indication to a rider when a braking surface on the rim has been worn off. The novel bicycle rim comprises a base portion, two lateral flanks forming an outer braking surface, and a longitudinal hole. The braking surface has a first portion and a second portion. The first portion of the braking surface has a thickness that is designed to be worn off down to the longitudinal hole so as to form a visible slit, while the second portion, situated radially outwards with respect to the first portion, has a thickness such as to prevent deformations of the second portion when the first portion is worn off down to the longitudinal hole.
Patent DK-0817858-T3 (DK)
Inventor: GUENZBURG WALTER H
IPC: A61K38/46
Filed: 1996-03-08
Granted: 2003-08-11
Abstract: The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral infections such as HIV infections and bacterial and fungal infections. In particular the present invention relates to retroviral vectors. Furthermore, the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.
Patent DK-0832093-T3 (DK)
Inventor: GRAY MARYANNE B
IPC: C07K19/00
Filed: 1996-06-05
Granted: 2007-01-08
Abstract: Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be  E.coli.  The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the  Borrelia OspA  leader sequence. The protein portion can be OspC, PspA, UreA, UreB, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.
Patent DK-0865428-T3 (DK)
Inventor: CALVERLEY MARTIN JOHN
IPC: A61K31/59
Filed: 1996-12-02
Granted: 2000-09-25
Abstract: PCT No. PCT/DK96/00502 Sec. 371 Date Jan. 8, 1998 Sec. 102(e) Date Jan. 8, 1998 PCT Filed Dec. 2, 1996 PCT Pub. No. WO97/20811 PCT Pub. Date Jun. 12, 1997The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R1 and R2 stand for methyl or ethyl, or, when taken together with the carbon atom bearing the group X, can form a C3-C5 carbocyclic ring; Q is either a single bond or a C1-C8 hydrocarbylene in which one of any methylene groups not directly bonded to the carbonyl group may optionally be replaced by an oxygen atom (or methyl by hydroxy); Y is either a single bond or C1-C8 hydrocarbylene; and derivatives of (I) in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.