baber/WOPTO huggingface dataset:
Patent DE-69524757-T2 (DE)
Inventor: JOHNSON C
IPC: A61F2/82
Filed: 1995-06-30
Granted: 2002-09-12
Abstract: A dilator formed with a truss with a pair of spaced-apart end surfaces that provides a restoring force therebetween if forced toward one another, this restoring force provided by a resilient band extending between the opposite ends of the truss with a plurality of notches at each end thereof. The notches exceed at least a third of the thickness of the band. A second and similar band may also be provided in the truss.
Patent DE-69525643-T2 (DE)
Inventor: MCKITTRICK A
IPC: A61K31/4427
Filed: 1995-11-15
Granted: 2002-09-26
Abstract: Sulfur-substituted azetidinone hypocholesterolemic agents of the formula    <IMAGE>  I  or a pharmaceutically acceptable salt thereof, wherein: Ar1 is aryl, R10-substituted aryl or heteroaryl; Ar2 is aryl or R4-substituted aryl; Ar3 is aryl or R5-substituted aryl; X and Y are -CH2-, -CH(lower alkyl)- or -C(dilower alkyl)-; R is -OR6, -O(CO)R6, -O(CO)OR9 or -O(CO)NR6R7; R1 is hydrogen, lower alkyl or aryl; or R and R1 together are =O; q is 0 or 1; r is 0, 1 or 2; m and n are 0-5; provided that the sum of m, n and q is 1-5; R4 is selected from lower alkyl, -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10-COOR6, -O(CH2)1-10CONR6R7, -(lower alkylene)-COOR6 and -CH=CH-COOR6; R5 is selected from -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10-COOR6, -O(CH2)1-10CONR6R7, -CF3, -CN, -NO2, halogen, -(lower alkylene)COOR6 and -CH=CH-COOR6; R6, R7 and R8 are H, lower alkyl, aryl or aryl-substituted lower alkyl; R9 is lower alkyl, aryl or aryl-substituted lower alkyl; and R10 is selected from lower alkyl, -OR6, -O(CO)R6, -O(CO)OR9, -O(CH2)1-5OR6, -O(CO)NR6R7, -NR6R7, -NR6(CO)R7, -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO2R9, -COOR6, -CONR6R7, -COR6, -SO2NR6R7, S(O)0-2R9, -O(CH2)1-10-COOR6, -O(CH2)1-10CONR6R7, -CF3, -CN, -NO2 and halogen; are disclosed, as well as pharmaceutical compositions containing them, and a method of lowering serum cholesterol by administering said compounds, alone or in combination with a cholesterol biosynthesis inhibitor.
Patent DE-69526065-T2 (DE)
Inventor: CHENE RICHARD
IPC: B21K1/16
Filed: 1995-11-02
Granted: 2002-11-07
Abstract: A method for shrinking a ring (14) fitted over the free end (10a) of a flexible tube (10) on a rigid tubular member (12). The method uses a shrinking die (16) with an axial cavity (18) including a splayed section (18a) and a broad open end (20) whereat the diameter of the cavity is substantially the same as the greatest diameter (d) of said section. The shrinking die (16) is positioned so that at least the broad end (20) of the cavity is located around the portion (14) to be shrunk while its narrow end is in front of the tube, and, while axially supporting one of the ring (14) and the shrinking die (16), both are mutually axially moved in a direction (F) extending from the free end (10a) of the tube (10) towards the other end thereof.
Patent DE-69529174-T2 (DE)
Inventor: MUELLER ROLF
IPC: A61P9/08
Filed: 1995-08-23
Granted: 2003-10-23
Abstract: PCT No. PCT/EP95/03370 Sec. 371 Date Apr. 18, 1997 Sec. 102(e) Date Apr. 18, 1997 PCT Filed Aug. 25, 1995 PCT Pub. No. WO96/06940 PCT Pub. Date Mar. 7, 1996A DNA sequence for the gene therapy of tumors is described. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated, in a cell-specific manner, in proliferating endothelial cells or in cells which are adjacent to these endothelial cells. This activation is regulated by the promoter module in a cell cycle-specific manner. The active substance is an inhibitor of angiogenesis or a cytostatic or cytotoxic molecule. The DNA sequence is inserted into a viral or non-viral vector which is supplemented with a ligand which possesses affinity for the activated endothelial cell.
Patent DE-69600791-T2 (DE)
Inventor: SCHELIGA WERNER
IPC: B29C45/40
Filed: 1996-02-08
Granted: 1999-06-17
Abstract: A molded cap for sealing a container, and having a core-profiled internal skirt portion is injection molded within a seamless annular cavity mold, wherein segmentation of the interior core die portion bearing the internal form such as a screw thread form for the inside of the cap skirt, permits its inward withdrawal clear of the cap after completion of the injection cycle. Due to the seamless mold cavity the cap has no externally visible mold witness lines along its skirt. The molded cap contracts radially as it cools within the mold, permitting molded parts and decorative features that are on or in the skirt face to withdraw radially inwardly from the mold surfaces, such that the cap can be ejected clear from the mold without damage to fine detailed or hang-up on undercuts into the mold skirt face.
Patent DE-69605031-T2 (DE)
Inventor: FREYMAN CHRISTOPHER
IPC: H01S5/00
Filed: 1996-04-22
Granted: 2000-07-20
Abstract: An improved laser diode assembly includes a laser diode unit which is mounted directly on a compact thermoelectric cooler, which is mounted on a heat sink. A thermally insulating gasket, mounted around the thermoelectric cooler, seals the thermoelectric cooler from the ambient environment, thereby preventing condensation from forming on the cold face of the thermoelectric cooler. A bushing concentrically positions the laser diode unit in the proper optical alignment with respect to the optical assembly, while thermally and electrically insulating the laser diode. A thermally conductive gasket, mounted around the circumference of the laser diode window, returns heat from the heat sink to the window to prevent condensation from forming on the window. The laser diode is the only component cooled by the thermoelectric cooler. Since a portion of the heat transferred by the thermoelectric cooler is utilized to warm the laser diode window, a separate heating element is not required. This increases the overall efficiency of the laser diode assembly.
Patent DE-69618229-T2 (DE)
Inventor: WALDENBERGER A
IPC: C08G18/10
Filed: 1996-09-10
Granted: 2002-11-21
Abstract: A pressure sensitive adhesive consisting of a polyurethane foam is used for adhering decorative parts to automobiles and other vehicles. The adhesive is characterized by high tensile strength and elongation, excellent peel strength and good thermal and mechanical stress tolerance.
Patent DE-69623146-T2 (DE)
Inventor: TOVEY DEFOREST W
IPC: G06F9/38
Filed: 1996-02-08
Granted: 2003-07-24
Abstract: In a microprocessor, an apparatus is included for coordinating the use of physical registers in the microprocessor. Upon receiving an instruction, the coordination apparatus extracts source and destination logical registers from the instruction. For the destination logical register, the apparatus assigns a physical address to correspond to the logical register. In so doing, the apparatus stores the former relationship between the logical register and another physical register. Storing this former relationship allows the apparatus to backstep to a particular instruction when an execution exception is encountered. Also, the apparatus checks the instruction to determine whether it is a speculative branch instruction. If so, then the apparatus creates a checkpoint by storing selected state information. This checkpoint provides a reference point to which the processor may later backup if it is determined that a speculated branch was incorrectly predicted. Overall, the apparatus coordinates the use of physical registers in the processor in such a way that: (1) logical/physical register relationships are easily changeable; and (2) backup and backstep procedures are accommodated. <IMAGE>
Patent DE-69701840-T2 (DE)
Inventor: DANVY DENIS
IPC: C07B53/00
Filed: 1997-02-04
Granted: 2000-10-12
Abstract: PCT No. PCT/FR97/00218 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 4, 1997 PCT Pub. No. WO97/29086 PCT Pub. Date Aug. 14, 1997Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in: a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride; b) preparing the monoacetates (VII R) or (VII S) respectively; c) subjecting these monoacetates to an oxidation in order to form the acids (IX S) or (IX R); d) saponifying the compounds (IX S) or (IX R) in order to form the hydroxy acids (X S) or (X R); e) thioacylating the hydroxy acids (X S) or (X R) with a mercapto acid R1SH (XI), according to a Mitsunobu-type reaction, in order to lead to the desired acids (I R) (I S) respectively and application to the synthesis of N-(mercaptoacyl)amino acid derivatives (II).
Patent DE-69714451-T2 (DE)
Inventor: CASHMAN R
IPC: G01N33/53
Filed: 1997-05-29
Granted: 2003-01-30
Abstract: In general, the invention features prion protein binding proteins (PrPBPs) and diagnostic, therapeutic, and decontamination uses thereof. The invention also features fusion protein reagents for PrPBP isolation.
Patent DE-69734683-T2 (DE)
Inventor: VINOGRADOV A
IPC: G01N21/64
Filed: 1997-12-12
Granted: 2006-08-17
Abstract: This invention relates to phosphorescent probes effective for oxygen measurement in human or animal tissue comprising a porphyrin chromophore capable of releasing absorbed energy as phosphorescent light and a dendrimer, wherein said porphyrin chromophore comprises the core of the dendrimer.
Patent DE-69734722-T2 (DE)
Inventor: DENNY ALEXANDER
IPC: A61K31/40
Filed: 1997-09-12
Granted: 2006-07-20
Abstract: The invention provides compounds of general formula (I), wherein: X is halogen or OSO2R, where R represents H or is unsubstituted or hydroxy- or amino-substituted lower alkyl; Y is a nitro or amine group or a substituted derivative thereof; W is selected from the structures of formulae (Ia, Ib or Ic), where E is -N= or -CH=, G is O, S, or NH, and Q is either up to three of R, OR, NRR, NO2, CONHR, NHCOR or NHCONHR, or is an additional group of formulae (Ia, Ib or Ic) and HET represents a 5- or 6-membered carbocycle or heterocycle; and A and B collectively represent a fused benzene or 2-CO2R pyrrole ring. In one embodiment, the group Y is an amine derivative substituted by a group which is a substrate for a nitroreductase or carboxypeptidase enzyme such that one of said enzymes is able to bring about removal of that group.
Patent DE-69801415-T2 (DE)
Inventor: HAVEAUX BERNARD
IPC: E04D5/06
Filed: 1998-01-08
Granted: 2002-05-29
Abstract: The present invention relates to bituminous compositions used for roofing and waterproofing membranes or material comprising asymmetrical coupled polyvinyl aromatic-polydiene block copolymers having improved physical properties over broader ranges of service temperatures than those obtained from bituminous compositions prepared with symmetrical block copolymers of similar type. The asymmetry of the copolymer which is characterised by polyvinyl aromatic endblocks of at least two different molecular weights, one high and one low, ensures improved physical performance to roofing and waterproofing membranes made from such compositions .
Patent DE-69804232-T2 (DE)
Inventor: GALLERI FRANCOIS
IPC: G07G1/00
Filed: 1998-09-11
Granted: 2002-11-21
Abstract: The invention concerns a system for dispensing goods comprising: before the pay-desk, in the customer zone, a control desk (1) for the customer to choose the types and number of goods, the control desk (1) delivering a receipt (2) to the customer; at the pay-desk, when the customer presents the receipt (2) to a pay-desk (4) reading device (3), an interface module (5), for transmitting data representing the customer's choice to a dispenser (6) of goods; after the pay-desk, a dispenser (6) for delivering goods corresponding to the data representing the customer's choice borne by the receipt (2).
Patent DE-69805924-T2 (DE)
Inventor: ANDERBOUHR STEPHANIE
IPC: C23C16/34
Filed: 1998-08-27
Granted: 2003-01-09
Abstract: A multilayer coating of titanium nitride and/or titanium aluminum nitride is produced by continuous thermal CVD from a gas mixture of a reducing gas, hydrogen and chloride precursors of titanium and optionally aluminum formed from a single titanium-aluminum alloy charge or target. The nature and/or composition of each layer is instantaneously adjusted during deposition by modifying the molar ratio of reducing gas to hydrogen in the gas mixture. Independent claims are also included for: (i) a multilayer coating produced by the above process; and (ii) a multilayer coating of titanium nitride and/or titanium aluminum nitride, including one or more graded composition titanium aluminum nitride layers.
Patent DE-69807617-T2 (DE)
Inventor: SARDOY VERONIQUE
IPC: C22C38/06
Filed: 1998-09-28
Granted: 2003-07-31
Abstract: In the production of double reduction quality steel strip for deep drawn container manufacture, aging is carried out between the two final cold rolling passes following recrystallization annealing. Steel strip, for manufacture of deep drawn containers, is produced from a hot rolled strip of steel of composition (by wt.) up to 0.08 % C, ≤ 0.020 % Si, 0.05-0.60 % Mn, ≤ 0.020 % S, ≤ 0.020 % P, up to 0.018 % N, up to 0.060 % Al, ≤ 0.06 % Cu, ≤ 0.040 % Ni, optionally Cr and B, balance Fe and impurities by cold rolling, continuous recrystallization annealing and cold rolling to final thickness in two passes separated by aging at ≤ 300 degrees C for several minutes to several days. An Independent claim is also included for a double reduction type steel strip which is used for manufacture of deep drawn containers and which has high mechanical strength and good formability, the strip having (i) a first network of dislocations formed during the first double reduction pass and pinned by carbon and/or nitrogen during aging treatment and (ii) a second network of dislocations formed during the second double reduction pass.
Patent DE-69825091-T2 (DE)
Inventor: BIQUEZ FRANCOIS
IPC: H01H21/58
Filed: 1998-02-26
Granted: 2005-07-28
Abstract: The construction has a number of fixed contact points (1) which engage a moving arm contact (2). The moving arm contact is moved longitudinally towards and away from the fixed contact by a series of levers (41,42). The two levers pivot around a central hinge point, sliding the contact into the fixed position (F) or by turning the two levers around, moving the contact to an open position (O).
Patent DE-69833551-T2 (DE)
Inventor: MORI NAOMICHI
IPC: G05B19/4097
Filed: 1998-07-03
Granted: 2006-08-31
Abstract: In a bending simulation apparatus, after a three-dimensional drawing generation portion generates a solid form from trihedral drawing data, a workpiece bending simulation portion places a workpiece for forming edge angles of a solid form on a die and carries out simulation operation for bending the workpiece completely up to the edge angle according to bending information including the edge angle of each side of the solid form, workpiece condition, tool condition and the like. An elongation amount of the workpiece is obtained by an elongation amount calculation portion and an elongation amount subtraction portion subtracts the elongation amount from a length of each side of the solid form. A development drawing generation portion creates a development drawing and an L-value calculation portion transmits Li value based on this development drawing to the press machine.
Patent DE-69902442-T2 (DE)
Inventor: DOMENGE ALBERTO G
IPC: A45D29/02
Filed: 1999-02-17
Granted: 2002-12-12
Abstract: An improved nail clipper having a central symmetrical resilient pincer member with cutting edges at its opened end, a transverse pin with hooked ends that pass through opposed and aligned bores on the jaws of the pincer member near its open end, and lateral handles that are connected at the hooked ends of the transverse pin.
Patent DE-69903950-T2 (DE)
Inventor: BROWN JOHN
IPC: C08F4/06
Filed: 1999-06-15
Granted: 2003-07-17
Abstract: Organometallic complexes having two phosphinimine ligands and at least one activatable ligand are catalyst components for olefin polymerization. Preferred polymerization systems are prepared by combining the organometallic complexes with an ionic activator and/or an alumoxane. Preferred catalyst components contain titanium, zirconium, or hafnium and are activated with an ionic activator to form catalysts for ethylene polymerization.
Patent DE-69909457-T2 (DE)
Inventor: LUIJKX CORNELIUS PETRUS MARIA
IPC: A47F7/00
Filed: 1999-03-31
Granted: 2004-05-27
Abstract: Device for presenting fresh products, in particular (cut) flowers, provided with containers for the fresh products which are arranged one above another and filled with liquid, at least one of which containers accommodates a liquid overflow for draining liquid therein to an underlying container, with the special feature that the liquid overflow is formed at least substantially by an at least partially lowered side wall of the container.
Patent DE-69909835-T2 (DE)
Inventor: PRESTON MEEK
IPC: B29C51/04
Filed: 1999-12-30
Granted: 2004-04-22
Abstract: Machine and method for stretching and then vacuum forming acrylic sheets. Machine has clamping bars (1-4), each of which has a plurality of secondary clamps (5) which move along the clamping bars proportionately to the stretching of the plastic sheet as it stretches but act to prevent bowing of the plastic sheet. Primary clamps (13, 14) hold the edges of the sheet in place after stretching during the vacuum forming process.
Patent DE-69914889-T2 (DE)
Inventor: BURK MARK JOSEPH
IPC: C07C67/303
Filed: 1999-04-09
Granted: 2004-12-09
Abstract: The present invention pertains to a process for the preparation of an enantiomerically enriched chiral carboxylic acid derivative having the partial formula: C-C-C-COOX wherein X is a cation, comprising formation of a dehydro precursor salt having the partial formula: C=C-C-COOX by reaction of the corresponding precursor acid with an at least substantially stoichiometric amount of base, and asymmetric hydrogenation of the salt in the presence of a transition metal complex of a chiral phosphine ligand.
Patent DE-69915103-T2 (DE)
Inventor: MIDOUX PATRICK
IPC: A61K47/48
Filed: 1999-11-22
Granted: 2004-12-09
Abstract: The invention relates to a positively charged oligomeric conjugate, containing an oligomer with a polymerization degree (PD) from 5 to 50, preferably 10 to 40 and more preferably 20, formed from monomeric components having free NH3<+> in a number equal to or higher than 50 % of the polymerization degree. In particular, the invention provides new oligomeric conjugates of histidylated oligolysine liable to allow the transfer of oligonucleotides, peptides and oligosides into cells.
Patent DE-69917898-T2 (DE)
Inventor: BJOERKMAN LARS
IPC: E06B3/46
Filed: 1999-03-18
Granted: 2005-06-30
Abstract: A frame structure, which is adapted to be mounted between a horizontal lower balcony slab (1) and a horizontal upper balcony slab (2) located straight above the former, is arranged to support wall plates (9, 10) for at least partial building-in of the space between the balcony slabs (1, 2). The frame structure has a lower horizontal sectional element (12) arranged to be attached to the lower balcony slab (1), an upper horizontal sectional element (11) arranged to be attached to the upper balcony slab (2), an intermediate horizontal sectional element (13) and two vertical sectional elements (14, 15). The upper and the intermediate horizontal sectional elements (11 and 13) are arranged to support between themselves wall plates (10), such as glass plates, which are horizontally displaceable relative to each other. The vertical sectional elements (14, 15) consist of hollow sectional elements. The intermediate horizontal sectional element (13) has a longitudinal draining groove (21), which leads into the hollow sectional element (14, 15).
Patent DE-69920681-T2 (DE)
Inventor: PARDO-FERNANDEZ LUIS ANGEL
IPC: C07K14/705
Filed: 1999-04-21
Granted: 2005-09-08
Abstract: The present invention relates to a novel human K+ ion channel, to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally relates to antibodies specifically directed to the novel K+ ion channel and to pharmaceutical compositions and diagnostic kits containing at least one of the above-mentioned components. Furthermore, the present invention relates to methods of treating a disease caused by malfunction of the polypeptide of the present invention or by the (over)expression of the nucleic acid molecule of the invention comprising administering an inhibitor of said (over)expression or of ion channel function or an inhibitor abolishing said malfunction to a patient in need thereof. Methods of devising drugs for treating or preventing the above-mentioned disease, methods of inhibiting cell proliferation and methods of prognosing cancer are additional embodiments comprised by the present invention. The invention also envisages specific antisense or gene therapies on the basis of the nucleic acid molecule of the invention for inhibiting undesired cellular proliferation, for example, in connection with cancer or in neurodegenerative diseases.
Patent DE-69922503-T2 (DE)
Inventor: FRESNEL ERIC
IPC: B65D55/08
Filed: 1999-05-12
Granted: 2005-12-15
Abstract: The invention concerns a safety envelope (20) formed by a sleeve (21) made of heat shrinkable plastic material, equipped on its inner surface with a tear strip (22) and a metal-coated identifying strip (23). The invention is characterised in that the metal-coated strip (23) is non-adhesive, and is sandwiched between the sleeve (21) inner surface and an adhesive surface of the tear strip (22). The tear strip (22) overlaps on the metal-coated strip (23) two sides so as to adhere to the sleeve (21) internal surface via zones located on either side of the metal-coated strip (23).
Patent DE-69923075-T2 (DE)
Inventor: FRIEDMAN MICHAEL
IPC: B32B27/08
Filed: 1999-07-26
Granted: 2005-12-29
Abstract: High clarity optical and safety glass laminate interlayer films and optical laminates are described. The films and their laminates comprise very low density polyethylene and/or its copolymers, preferably polymerized with metallocene catalysts, and modified with additives, such as coupling agents, clarifying or nucleation agents, UV-light absorbers, pigment or color concentrate, and IR-light blockers. The very low density polyethylene is laminated to EVA film for improved bondability in optical laminates.
Patent DE-69923691-T2 (DE)
Inventor: BORNSTEIN ROLF
IPC: A61K6/50
Filed: 1999-07-16
Granted: 2005-12-15
Abstract: The invention relates to a method and a preparation for cleaning tooth root surfaces and surrounding tissue (periodontal pockets). The preparation is a two-component liquid of the type that has previously been used for chemical-mechanical treatment of carious lesion. The active component in the liquid is a hypochlorite, preferably sodium hypochlorite, and the other component in the liquid is a component which reduces the aggressiveness of the hypochlorite on healthy tissue and which also increases the viscosity of the liquid. The preparation is applied on the tooth root surface in question by means of a brush or an applicator instrument. After 10-15 seconds the root surface is cleaned by means of a scraping instrument.