Patent EP-2674480-A1 (EP)
Inventor: ARNOLD MATTHIAS
IPC: C12M1/04
Filed: 2012-06-15
Abstract: Biotechnological apparatus comprises a bioreactor, an exhaust gas conduit designed and configured on the bioreactor to remove gases produced in a reactor vessel of the bioreactor during cultivation, and an exhaust gas temperature control device designed free of temperature control fluid and having a temperature control actuator, where the exhaust gas temperature control device is arranged in releasable connection with the exhaust gas conduit with the aid of a connector device and thermally coupling the temperature control actuator to the exhaust gas conduit. Independent claims are: (1) an exhaust gas temperature control device for a bioreactor and designed free of temperature control fluid, comprising a temperature control actuator designed free of temperature control fluid and configured to control the temperature of an exhaust gas conduit of a bioreactor, and a coupling mechanism assigned to a connector device, with which the temperature control actuator can be releasably mounted on the exhaust gas conduit and thermally coupled to it; (2) a method for treating an exhaust gas stream in a biotechnological apparatus formed with a bioreactor, comprising removing, via an exhaust gas conduit, a stream of gases produced during cultivation in a reactor vessel of the bioreactor, controlling the temperature of the exhaust gas stream in the exhaust gas conduit by an exhaust gas temperature control device designed free of temperature control fluid, in such a way that the exhaust gas stream condenses at least partially, and providing at least one part of the condensate formed when controlling the temperature of the exhaust gas stream for return to the cultivation process in the reactor vessel; (3) a reusable connection device for a sterile single-use fluid conduit of a single-use bioreactor, comprising a receptacle in which a portion of a fluid conduit can be detachably arranged, and a coupling member having a coupling face for connecting the connection device to a temperature control device, where the receptacle has a contact surface which is arranged and adapted in such a way that the contact surface abuts a fluid conduit arranged in the receptacle, and where a portion of a fluid conduit can be introduced into the receptacle in a direction running substantially orthogonally to a longitudinal axis of the connection device; (4) a reusable temperature control device for controlling the temperature of a sterile single-use fluid conduit of a single-use bioreactor, comprising a temperature control actuator which does not contain any temperature control fluid, characterized by a connection device for connecting the temperature control device to a fluid conduit of a single-use bioreactor; (5) a biotechnological device comprising a single-use bioreactor provided with a sterile single-use fluid conduit and a reusable temperature control device, and/or a reusable connection device; and (6) a method for treating a fluid stream in a biotechnological device, comprising supplying or discharging a fluid stream from a or into a single-use bioreactor via a sterile single-use fluid conduit, and arranging a reusable connection device on a portion of a fluid conduit.