baber/WOPTO huggingface dataset:
Patent NZ-530909-A (NZ)
Title: DNA-PK inhibitors
Inventor: GRIFFIN ROGER JOHN
IPC: A61K31/5375
Filed: 2002-08-14
Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.
Patent NZ-531798-A (NZ)
Title: Benzothiepine ileal bile acid transport inhibitors
Inventor: STARKE INGEMAR
IPC: A61P31/04
Filed: 2002-09-05
Abstract: Compounds of formula (I), pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia are disclosed, wherein Rx, Ry, Rz, v, R1, R2, R3, R4, R5 and R6 are as defined in the specification. Processes for their manufacture and pharmaceutical compositions containing them are also disclosed.
Patent NZ-537480-A (NZ)
Title: Use of vasopeptidase inhibitors in the treatment of nephropathy
Inventor: SCHAFER STEFAN
IPC: A61K38/00
Filed: 2003-06-13
Abstract: The use of a compound of formula (II) wherein R1 is hydrogen or acetyl; R2 is hydrogen, -CH2O-C(O)C(CH3)3, C1-C4-alkyl, aryl, -(C1-C4-alkyl)-aryl, or diphenylmethyl; X is -(CH2)n wherein n is an integer 0 or 1, -S-, -O-, NR3 or N(CO)R4 wherein R3 is hydrogen, C1-C4-alkyl, aryl, or -(C1-C4-alkyl)-aryl; and R4 is CF3, C1-C10-alkyl, aryl, or -(C1-C4-alkyl)-aryl; B1 and B2 are each independently hydrogen, hydroxyl, or -OR5, wherein R5 is C1-C4-alkyl, aryl, or -(C1-C4-alkyl)-aryl or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbon atoms to form a benzene ring or methylenedioxy, or a pharmaceutically acceptable salt or stereoisomer thereof, for the manufacture of a medicament for inhibiting both angiotensin converting enzyme and neutral endopeptidase for treatment or prevention of a disease amenable to treatment with a compound that inhibits both angiotensin converting enzyme and neutral endopeptidase wherein the disase is selected from the group consisting of diabetic nephropathy, insulin resistance, diabetic neuropathy, diabetic retinopathy, myocardial infarction, cataracts, diabetic cardiomyopathy and non-diabetic nephropathy, is disclosed.
Patent NZ-537682-A (NZ)
Title: Multicomponent pharmaceutical dosage form
Inventor: BONNEY STANLEY GEORGE
IPC: A61K9/48
Filed: 2003-07-24
Abstract: Disclosed is a multi-component pharmaceutical dosage form characterised by a body comprising a base wall having an upper surface, a first cavity defined by a skirt wall extending away from the upper surface of the said base wall to terminate in a rim defining a first mouth opening, a second cavity is defined by a skirt wall extending away from the lower surface of said base wall to terminate in a rim defining a second mouth opening, and a first and second film means connected to the body closes the first and second mouth openings. Also disclosed is a multi-component pharmaceutical dosage form characterised by a first body which comprises a first capsule shell defining a first cavity, having a first mouth opening and an opposite closed end, a second body which comprises a closure for the first mouth opening, and the second body defines a second cavity having a second mouth opening facing toward the closed end of the first body when the second body is in place as a closure, and the second mouth opening is closed by a film means connected to the second body, such that the film means closes the second mouth opening and is between the first and second cavities, and further comprising a second capsule shell defining a further cavity, having a further mouth opening and an opposite closed end, and the second body comprises a closure for this further mouth opening of this second capsule shell. The body and/or the film means is made of materials selected from a polymer which dissolves or disintegrates in the environment of the upper or lower digestive tract, or which hydrolyses in the digestive tract, such that the dosage form opens to release the drug substance in the gastrointestinal environment.
Patent NZ-539973-A (NZ)
Title: Application of conductive absorbents, activated carbon granules and carbon fibers as substrates in catalysis
Inventor: JANGBARWALA JUZER
IPC: B01J23/80
Filed: 2003-11-19
Abstract: Disclosed is a method for conducting a chemical reaction in the presence of a catalyst, wherein the method comprises: providing said catalyst on a support of electrically conductive carbonaceous material comprised of carbon fibers and carbon nanotubes; and supplying an electric current to said support such that said support passes said electric current to said catalyst, wherein electrical resistively heats said catalyst to a temperature effective to activate the catalyst.
Patent NZ-543728-A (NZ)
Title: Multi-shank ripper
Inventor: HORTON LEE A
Filed: 2005-11-23
Abstract: A multi-shank ripper excavation tool 70, for use mounted to an arm 24 of an excavation machine, comprises a body 74 and a set of multiple shanks 76, 78, 80 mounted to the body 74. Each shank is disposed generally perpendicularly to an axis of rotation of the tool relative to the arm 24, and has a ripper tooth 77, 79, 81 disposed at a forward end for ripping engagement with a substrate. One or more plate members 87, 89 are mounted to span between two or more shanks 76, 78, 80 to define a bucket volume V for receiving material ripped from the substrate.
Patent NZ-545300-A (NZ)
Title: Indole-4-sulfonamide derivatives, their preparation and their use as 5-ht-6 modulators
Inventor: MERCE VIDAL RAMON
IPC: A61P3/04
Filed: 2004-07-29
Abstract: Disclosed is a compound of formula (Ia), wherein the substituents are as defined in the specification. Also disclosed is a process for preparing the compounds, which are 5-HT6 serotonin receptor modulators useful in the treatment of central nervous system and gastrointestinal disorders.
Patent NZ-545782-A (NZ)
Title: Plastic body with an inorganic coating method for production and use thereof
Inventor: BECKER PATRICK
IPC: B29C39/02
Filed: 2004-07-02
Abstract: This discloses a process for producing a plastics article from a plastic obtainable via free radical polymerization with inorganic coating on one or more sides using the following process steps: a) using doctoring, flow coating, or immersion to coat a substrate with a lacquer composition which consists of 1 to 2% by weight of SiO2 particles and from 2.5 to 7.5% by weight of antimony tin oxide particles in water as solvent, where no polymerizing organic components are present and, where appropriate, a flow control agent may be present, b) drying the lacquer composition on the substrate, thus obtaining the coated substrate, c) using one or more substrates thus coated to construct a polymerization cell, where the coated sides are in the interior of the cell, d) charging a polymerizable liquid composed of monomers capable of free-radical polymerization, where appropriate with polymeric content, to the polymerization cell, e) free-radical polymerization of the polymerizable liquid in the presence of a polymerization initiator, whereupon the internal inorganic coating transfers from the substrate into or onto the surfaces of the free-radical-polymerized plastic or of the plastics article, and f) removing the coated plastics article with inorganic coating on one or more sides from the polymerization cell.
Patent NZ-547303-A (NZ)
Title: Calpain inhibitors and compositions
Inventor: ABELL ANDREW DAVID
Filed: 2006-05-18
Abstract: Disclosed are compounds that inhibit calpains of formula I wherein X is NH, O or S and all other substituents are as described in the specification. The process for their production, and use in pharmaceutical compositions and in the treatment of prophylaxis of a disease or disorder resulting from excessive calpain activity is also disclosed.
Patent NZ-547576-A (NZ)
Title: Traffic cone with flexible link between base and cone
Inventor: LAWRENCE RODNEY JOHN
Filed: 2006-05-31
Abstract: A road marker "cone" has a base part 20 and a cone body 10 projecting upward from the base. The cone body is coupled to the base by coupling fingers 21 integrated with a coupling ring 19 which allow the cone to move with respect to the base when a forced is applied to the cone. The cone and base are not intended to be separated when the cone is struck as in some of the prior art road markers.
Patent NZ-551282-A (NZ)
Title: Bicyclic heterocycles as HIV integrase inhibitors
Inventor: NAIDU NARASIMHULU B
IPC: C07D498/04
Filed: 2005-05-12
Abstract: Provided is a series of specified bicyclic pyrimidinone compounds and the use of the compounds for the manufacture of a medicament to treat HIV either alone or in combination with HIV reverse transcriptase, protease, fusion, attachment and other inhibitors.
Patent NZ-565727-A (NZ)
Title: Multiple nozzle venturi system for watercraft
Inventor: SMITH TERRENCE L
IPC: B63H5/00
Filed: 2006-06-12
Abstract: A multiple nozzle Venturi system 10A for watercraft comprises a first hemispherical component and a second hemispherical component, both the first hemispherical component and the second hemispherical component including a hemispherical structural ring 18 and two or more hemispherical nozzle rings 22, 24 the first hemispherical component and the second hemispherical component including two or more ring connecting fin struts 16 spanning, separating and integrated into the structural ring 18 and the two or more nozzle rings 22, 24 the first hemispherical component and the second hemispherical component further including an upper mounting plate 26 and a lower mounting plate 31 spanning, separating and integrated into the structural ring 18 and the two or more nozzle rings 22, 24 and a skeg shield 32 including a T-shaped skid plate 36 sandwiched between the lower mounting plate 31 of the first hemispherical component and the second hemispherical component including an upper portion and a lower portion where the lower portion is removably attachable to the lower mounting plate of both the first and second hemispherical components. The T-shaped skid plate 36 further includes a skeg lock 42 adjustable in construction to fit a skeg located on the lower portion of a watercraft motor, where the skeg lock 42 functions to stabilize the watercraft when in motion in reverse, and reinforces any fasteners used to attached the skeg shield 32, the T-shaped skid plate 36 and the lower mounting plate 31, and where the upper mounting plate 26, the lower mounting plate 31, the skeg shield 32, and the skeg lock 42, are fastened to the watercraft motor using steel fasteners.
Patent NZ-577489-A (NZ)
Title: Low foaming cleaning composition that provides surface disinfection with low residue of films and streaks
Inventor: SHIMMIN LAURA
IPC: C11D3/20
Filed: 2008-12-15
Abstract: A cleaning composition is disclosed, which comprises:(a) 0.1 to 5.0 weight % of a C8 to C10 alkylpolyglucoside wherein the alkyl group is substantially C8 alkyl, substantially C10 alkyl, or a mixture of substantially C8 and C10 alkyl; (b) 0.5 to 5.0 weight % of a C2 to C4 alcohol or combination of C2 to C4 alcohols; (c) 0.05 to 2.0 weight % of glycerol; (d) optionally 0.01 to 5.0 weight % of a water-soluble organic acid selected from the group consisting of acetic acid, citric acid and formic acid; and(e) optionally dyes, builders, fatty acids, fragrances, colorants, anti-foaming agent, water-soluble organic acid, and preservatives.
Patent NZ-582619-A (NZ)
Title: Humanized anti-fgf19 antagonists and methods using same
Inventor: FRENCH DOROTHY
IPC: A61P35/00
Filed: 2008-08-01
Abstract: Disclosed is a humanized anti-FGF19 antibody comprising: (i) a light chain comprising (a) hypervariable region (HVR)-L1 sequences comprising sequence A1-A11, wherein A1-A11 is KASQDINSFLA (SEQ ID NO:11); (b) HVR-L2 comprising sequence B1-B7, wherein B1-B7 is RANRLVD (SEQ ID NO:2), RANRLVS (SEQ ID NO:13), or RANRLVE (SEQ ID NO:14); and (c) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is LQYDEFPLT (SEQ ID NO:3); and (ii) a heavy chain comprising (a) HVR-H1 comprising sequence D1 -D10, wherein Dl-D10 is GFSLTTYGVH (SEQ ID NO:4); (b) HVR-H2 comprising sequence El-E17, wherein El-E17 is GVIWPGGGTDYNAAFIS (SEQ ID NO:7); and (c) HVR-H3 comprising sequence Fl-F13, wherein Fl-F13 is VRKEYANLYAMDY (SEQ ID NO:8). Also disclosed is the use of the antibody in the preparation of a medicament for treatment of a tumor, a cancer or a cell proliferation disorder.
Patent NZ-585197-A (NZ)
Title: System and method for filter kernel interpolation for seamless mipmap filtering
Inventor: BURLEY BRENT
IPC: G06T7/40
Filed: 2010-05-07
Abstract: A method of implementing a filter kernel interpolation for seamless filtering of transitions within a plurality of mipmaps derived from a base-image texture filtered using a pre-filter is disclosed. The method comprises determining a filter width in pixels for use with a filter kernel. The pixels correspond to texels of the base-image texture. Further a first mipmap and a second mipmap from the plurality of mipmaps are selected with the first mipmap having a mipmap level based on the filter width and the second mipmap having a mipmap level one higher than the first mipmap. An interpolation on the filter kernel based on the pre-filter, the first mipmap, and the second mipmap is applied to generate an interpolated filter kernel. Further the interpolated filter kernel is applied using texels of the first mipmap to generate a filtered texture having a seamless filtering of a transition between the first mipmap and the second mipmap. A rendering device implementing the above described filter kernel interpolation for seamless filtering of mipmap transitions is disclosed. The rendering device comprises a memory including a base-image texture and a plurality of mipmaps derived from the base-image texture filtered using a pre-filter; and a processor configured to implement the above described method.
Patent NZ-586232-A (NZ)
Title: HCV protease inhibitors comprising a functionalised proline derivative
Inventor: NIU DEQIANG
IPC: A61K31/40
Filed: 2008-12-19
Abstract: Disclosed are compounds of Formula I, salts thereof, and methods for their preparation. Specific examples of compounds of Formula I include: (1aR,3aS,5R,9S,16aS,Z)-11-acryloyl-9-(tert-butoxycarbonylamino)-1a-(cyclopropylsulfonylcarbamoyl)-3,5-dioxo-1,1a,2,3,3a,4,5,6,S,9,10,11,12,13,14,16a-hexadecahydrocyclopropa[n]pyrrolo[2,1-c][1,4,5]triazacyclopentadecin-5-yl-4-fluoroisoindoline-2-carboxylate, (1aR,3aS,5R,9S,16aS,Z)-13-acryloyl-9-(tert-butoxycarbonylamino)-1a-(cyclopropylsulfonylcarbamoyl)-3,8-dioxo-1,1a,2,3,3a,4,5,6,8,9,10,11,12,13,14,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4,10]triazacyclopentadecin-5-yI 4-fluoroisoindoline-2-carboxylate, and (3R,5S)-1-((S)-3-acrylamido-2-(tert-butoxycarbonylamino)propanoyl)-5-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl 4-fluoroisoindoline-2-carboxylate. Compounds of Formula I are inhibitors of hepatitis C (HCV) protease. The compounds can inhibit the HCV protease, or a mutant thereof, activity irreversibly by covalently modifying a cysteine residue conserved at an equivalent position to Cys159 of HCV protease subtype 1b.
Patent NZ-587750-A (NZ)
Title: Molecular diagnosis and classification of malignant melanoma
Inventor: KASHANI-SABET MOHAMMED
IPC: C12Q1/68
Filed: 2009-03-05
Abstract: Disclosed is a method for diagnosing melanoma in a subject, the method comprising the steps of: (a) contacting a biological sample from the subject with six reagents, each one of which specifically binds to a marker consisting of: (i) the polypeptides ARPC2, FNI, NCOA3, ROS1, SPP1, and WNT2, or (ii) the nucleic acids encoding the polypeptides; and (b) determining whether or not each of the selected markers is over expressed in the sample relative to a normal cell or nevi; thereby providing a diagnosis for melanoma in the subject.
Patent NZ-598970-A (NZ)
Title: Suture device using an enlongated body with barbs and a needle at one end and an anchor to prevent pull-through at the other end
Inventor: RUFF GREGORY L
IPC: A61B17/06
Filed: 2005-05-16
Abstract: 598970 Disclosed is a barbed suture for closing wounds in tissue. The suture comprises an elongated body with one pointed end or needle and a plurality of barbs extending from the periphery of the body. The barbs permit movement of the suture through the tissue in the direction of movement of the pointed end and prevent movement of the suture in a direction opposite the direction of movement of the pointed end. The other end has an anchor including at least one arcuate limb extending outside the periphery of the body to a greater degree than the barbs, the anchor preventing movement of the suture in the direction of movement of the pointed end. The anchor is a structure selected from the group consisting of: an elongated bar, a plurality of limbs each having different lengths, a plurality of limbs that are concave toward the pointed end, an elongated bar having a plurality of pointed elements extending from the bar toward the pointed end, a hemispherical anchor, a coneflower, a harpoon, a hook, and an M shape. The anchor has a plurality of arcuate or concave or convex curved limbs each of a different length that are substantially evenly or unevenly spaced around the body of the suture.
Patent NZ-600779-A (NZ)
Title: Turbine assemblies
Inventor: WINTER ALEXEI IVAN
IPC: F03B3/12
Filed: 2010-12-20
Abstract: 600779 Disclosed is a power generation turbine assembly which comprises a plurality of turbine blades, such as a tidal turbine. Each blade has a setting angle distribution along the length of the blade such that the thrust coefficient of the blade increases with rotational speed of the turbine assembly up to a first rotational speed and decreases by 20% or more between the first rotational speed and a runaway speed of the turbine assembly. This provides passive over speed control, and reduces or eliminates the need for variable pitch control or braking systems.
Patent NZ-601521-A (NZ)
Title: Trypsin-like serine protease inhibitors, and their preparation and use
Inventor: JELAKOVIC STJEPAN
IPC: A61K31/445
Filed: 2011-01-28
Abstract: The disclosure provides compounds that are effective as inhibitors of trypsin-like serine proteases, such as human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The disclosure further provides methods of making and using the compounds. the compounds of the disclosure are dipeptides which include non-naturally occurring amino acids.
Patent NZ-603804-A (NZ)
Title: Process for the preparation of pleuromutilins
Inventor: RIEDL ROSEMARIE
IPC: A61K31/215
Filed: 2011-05-23
Abstract: 603804 Process for the preparation of a Compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a Compound of formula IIa or in a mixture of a compound of formula IIa With a compound of formula IIb and isolating a Compound of formula I from the reaction mixture; Compounds and salts of Compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a Compound of formula I. some of the exemplified compounds of formula I include: 14-O-{ [(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl} -mutilin acetate in crystalline Form A; 14-O-{ [(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl} -mutilin acetate in crystalline Form B 14-O-{ [(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl} -mutilin L-Iactate in crystalline Form 1, and 14-O-{ [(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl} –mutilin hydrogenmaleate in crystalline Form 1.
Patent NZ-618559-A (NZ)
Title: Improvements relating to couplers
Inventor: BALEMI TIMOTHY CRAIG
IPC: E02F3/96
Filed: 2012-06-06
Abstract: A coupler assembly (15) in particular for coupling implements to vehicles such as diggers. The assembly (15) has a first connecting pin (19) and a second connecting pin (23). The coupler has: a body component (31) that is connectable to the vehicle, and which includes a forward recess (21) for receiving the first connecting pin (19); a movable component (27) which is supported by the body component (31) and is movable through a range of travel relative to the body component (31), and which includes, or forms a part of, an aft recess (25) for receiving the second connecting pin (23); and an actuator for selectively moving the movable component (27) relative to the body component (31). The movable component (27) includes a rear locking member which is movable between an extended position in which the rear locking member can prevent the second connecting pin (23) from exiting the aft recess (25) and a retracted position in which the rear locking member (37) can allow the second connecting pin (23) to exit the aft recess (25).
Patent NZ-620585-A (NZ)
Title: Grinding apparatus
Inventor: VAN DER VEEN TIM
IPC: B24B41/00
Filed: 2012-07-25
Abstract: A grinding apparatus (10) for grinding a floor comprises a body or chassis (11) to which is wheels (12) are attached and at least a first and second grinding head (14, 15) mountable to the body (11). Each grinding head (14, 15) incorporates three rotating grinding tools in the form of grinding discs (20). The grinding tools 20 are mounted on a plate or ring that rotates in addition to the rotating tools. Each grinding head (14, 15) has a separate driving mechanism. The first and second grinding heads (14, 15) are mountable to the body (11) in a manner that enables the position of the first and second grinding heads to be varied relative to the body. This is achieved by connecting the heads (14, 15) to a common mounting arm (21) articulates with respect to the body (11) via a pivot mounting (22) to the body. Also, each of the heads can be raised or lowered independently of one another.
Patent NZ-704014-A (NZ)
Title: Formulations and methods of manufacturing formulations for use in colonic evacuation
Inventor: FATHI REZA
IPC: A61P1/10
Filed: 2013-07-26
Abstract: Formulations and methods of manufacturing formulations for use in colonic evacuation are disclosed herein, in an embodiment, a solid dosage formulation includes an intra-granular fraction intermingled with an extra-granular fraction, wherein the intra- granular fraction includes granules comprising at least one osmotic evacuant agent, at least one antacid, and a first pharmaceutically acceptable excipient component, and wherein the extra-granular fraction includes one or more organic acids, a non-metallic lubricating element, and a second pharmaceutically acceptable excipient component.
Patent NZ-707752-A (NZ)
Title: Novel selective androgen receptor modulators
Inventor: VERHOEST PATRICK ROBERT
IPC: C07D417/04
Filed: 2013-11-25
Abstract: The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or -CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2 )q --, --(CHRS )q --, or -(CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.