baber/WOPTO huggingface dataset:
Patent PT-1776360-E (PT)
Title: 3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as alpha.7-nachr ligands for the treatment of cns diseases.
Inventor: TROXLER THOMAS J
IPC: C07D487/08
Filed: 2005-07-13
Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I)   
wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acelylcholine receptors (NACHR) ligands.
Patent PT-1778637-E (PT)
Title: Fkbp-binding composition and pharmaceutical use thereof
Inventor: JIMONET PATRICK
IPC: A61P25/00
Filed: 2005-06-24
Abstract: A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of Formula (I), wherein, R, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB> and X are as defined herein.
Patent PT-2047857-E (PT)
Title: Agent for injection purposes comprising antibiotic, and solution for injection comprising the agent
Inventor: MACHIDA HARUHIKO
IPC: A61K9/08
Filed: 2007-06-28
Abstract: A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A 2 , as an active ingredient, which is stable and contains WAP-8294A 2  in high concentrations is provided. This composition comprises WAP-8294A 2  of the following structural formula (1) as an active ingredient and is  characterized in that  2-hydroxypropyl-²-cyclodextrin or ²-cyclodextrin is contained as a stabilizer or solubilizer and the pH of the composition is not adjusted. This composition is mixed with a pH-adjusting agent such as dextrose and with an infusion or diluent comprising a solution of disodium hydrogen phosphate, sodium dihydrogen phosphate, and sodium hydroxide at the time of use to prepare a solution for intravenous administration of WAP-8294A 2 .
Patent PT-2116243-E (PT)
Title: Gel composition for treating mycosis
Inventor: OKUMURA TOMOHIRO
IPC: A61K9/06
Filed: 2007-12-28
Abstract: The present invention aims to provide a gel composition for mycosis treatment, which ensures good absorption and permeation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol into a target site (skin and nail). The present invention also aims to provide a gel composition for mycosis treatment, which is excellent in stability of this drug.  It is a gel composition for mycosis treatment, which comprises (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol or an acid addition salt thereof, a lower alcohol, a polyhydric alcohol and a gel-forming polymer.  The gel composition of the present invention is excellent in permeation of KP-103 into a target site and also excellent in permeation into the nail. Thus, the gel composition of the present invention allows the drug to be directly and rapidly absorbed and permeated into a target site in a constant manner, and thereby produces an excellent effect in mycosis treatment, particularly onychomycosis treatment.
Patent PT-1975177-E (PT)
Title: An appetite-suppressing peptide, its compositions and use
Inventor: THIM LARS
IPC: A61K38/00
Filed: 1997-02-27
Abstract: A claimed composition comprises a peptide of formula (I), given in one letter amino acid code, and an appetite-suppressing or satiety-inducing agent, preferably administered with glucagon-like peptide (GLP)-1. X1HX2DGSFSDEMNTX3LDX4LAX5X6DFINWLX7X8TKITDX9 (I) X1 = absent, DFPEEVAIVEELGRR, DFPEEVTIVEELGRR, or a fragment of these; X2 = A or G; X3 = I or V; X4 = N, S or H; X5 = A or T; X6 = R or K; X7 = I or L; X8 = Q or H; X9 = absent, K, R, RK, KR, RR or KK. Also claimed is the use of a composition comprising a peptide of formula (I) for: (a) appetite suppression or satiety induction; and (b) prophylaxis and treatment of obesity or type II diabetes.
Patent PT-2085170-E (PT)
Title: Crushing apparatus for demolition or similar works
Inventor: ANDRINA GIOVANNI
IPC: B23D31/00
Filed: 2009-01-29
Abstract: A crushing apparatus for demolition works comprises a main body (12) having a connecting portion (14) intended to be connected to the end of a handling arm (16), and at least a swingable jaw (24) articulated to the main body (12) at a distal portion (20) with respect to the connecting portion (14), which is adapted to allow, during a demolition work, that a member to be demolished (C) is grasped. Actuator means (34; 35) are interposed between each swingable jaw (24) and the main body (12), which are intended to control the movement of the respective jaw (24). The apparatus comprises percussion means (46, 50; 52) adapted to carry out an action of percussion on a member to be demolished (C), while it is grasped by said at least one jaw (24).
Patent PT-2248565-E (PT)
Title: Observation wheel type ride
Inventor: BUSSINK RONALD A
IPC: A63G27/00
Filed: 2009-05-05
Abstract: An observation wheel type ride, including a support structure (1), a wheel (3), said wheel being rotatable mounted in said support structure (1) and/or including transportation means, which are movable supported on the wheel (3), and a drive mechanism (8), including a rotary drive and a drive (8) cable, whereas a section of the drive cable (12) is detachably fixed to a circumference of the wheel (3) and/or to the transportation means for transmitting the rotary movement of the rotary drive to the wheel (3) and/or to the transportation means, is characterized by deflection means (14) for deflecting in a lateral direction with respect to the wheel (3) that section of the drive cable, which is led over the rotary drive (8).
Patent PT-2358374-E (PT)
Title: Improved dissolution stability of calcium carbonate tablets
Inventor: OLSEN PEDER MOHR
IPC: A61K9/20
Filed: 2009-11-17
Abstract: The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
Patent PT-667889-E (PT)
Inventor: KITTLE KEVIN JEFFREY
IPC: C09D201/00
Filed: 1993-11-05
Abstract: PCT No. PCT/GB93/02288 Sec. 371 Date Jun. 12, 1995 Sec. 102(e) Date Jun. 12, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/11446 PCT Pub. Date May 26, 1994A power coating composition comprises at least one film-forming polymeric material and has dry-blended therewith two or more dry-blended additives selected from solid, particulate, inorganic, water-insoluble materials which may be ceramic or mineral materials and/or may be oxides, mixed oxides, hydrated oxides, hydroxides, oxide-hydroxides or oxysalts of metals and metalloids, at least 95% by volume of the powder coating composition having a particle size not exceeding 50 microns.
Patent PT-715849-E (PT)
Inventor: GRIMFORS CHRISTER
IPC: C07C237/06
Filed: 1992-01-03
Abstract: The invention relates to the use of a compound according to formula (I) <CHEM>  in which X is an integer of from 2 to 5 and     A signifies - NH - C(=NH) - NH2 or - CH2 - NH2 for the preparation of a medicament for treatment of endotoxin-induced effects, particularly for suppressing endotoxin-induced pyrexia. The medicament is preferably administered orally, intravenously, intramuscularly, intracutaneously or intraperitoneally in an amount of 10-800 mg/kg body weight and hour.
Patent PT-742714-E (PT)
Inventor: SMITH ALAN
IPC: A61K47/10
Filed: 1995-01-30
Abstract: Liquid pharmaceutical compositions comprising at least one thyroid hormone, ethanol, a pH adjusting agent, and water are disclosed. The compositions may be delivered by a metered dosage delivery system such as an aerosol or pump-action spray, and are useful in the treatment of disorders associated with an impairment of thyroid hormone function in animals including human beings.
Patent PT-772619-E (PT)
Inventor: KRIEG ARTHUR M
IPC: C12Q1/68
Filed: 1995-02-07
Abstract: Stabilised immunostimulatory oligonucleotides which contain at least one unmethylated CpG dinucleotide for medicinal use.
Patent PT-758871-E (PT)
Inventor: MARIN MICHAEL
IPC: A61F2/06
Filed: 1995-05-11
Abstract: A device for delivering and deploying a graft stent complex comprises a flexible guide sheath, the outer diameter of the guide sheath being constant throughout its length and the inner diameter of the guide sheath increasing from the proximal end to the distal end. A hemostatic valve having at least two ports is attached to the proximal end of the guide sheath, one port adapted to permit passage of a catheter into the guide sheath and the other port adapted to permit passage of a fluid into the guide sheath. A lead balloon catheter extends through the first port into the guide sheath, and includes an inflatable lead balloon at its distal end. A portion of the lead balloon extends from the distal end of the guide sheath to provide a tapered leading surface and also to seal the distal end of the guide sheath. Deployment means are provided within the guide sheath, with the stent being mounted on the deployment means. The deployment means includes an elongated shaft having a guide wire lumen disposed in colinear relationship with the guide wire lumen of the lead balloon catheter. Fluid may be applied under pressure to the second port of the hemostatic valve to vary the flexibility of the guide sheath.
Patent PT-774896-E (PT)
Inventor: LANDHAM ROWENA ROSHANTHI
IPC: B65D81/28
Filed: 1995-07-06
Abstract: The present invention provides a gel formulation comprising the components: a. an agrochemical (such as a herbicide, insecticide, fungicide, adjuvant, synergist or penetrant); b. an inorganic particulate filler (such a flame hydrolysed silica) having a surface area in the range 10 to 400 m2/g, the surface of said filler having hydrophilic characteristics; c. an activator having a polar group capable of interacting with component b to produce a gel; and optionally, d. a diluent.
Patent PT-782239-E (PT)
Inventor: SOBROWIAK LUCIEN
IPC: H02K15/00
Filed: 1996-12-18
Abstract: The process involves separation of the connecting element (3) from one of the pipes joining it to the circuit, for access to an aperture (6) through which the laser beam (16) can be directed at the oxide layer covering the internal surface (18) of the cavity (19). Particles disengaged by the laser beam are sucked out of the cavity, and a brazed coating is deposited on its internal surface and melted. The laser head (8) is wired (11) to an electronic control cabinet (12) and connected by an optical fibre (10) to a focusing device (9) which is moved through a scanning angle ( alpha ) by a programmed robot (14).
Patent PT-842279-E (PT)
Inventor: MEHTALI MAJID
IPC: C12N7/01
Filed: 1996-07-30
Abstract: A novel helper virus (HV) for producing a replication-defective recombinant viral vector (rVV) comprises two recombination sequences, each recognised by a recombinase, located 5' and 3', respectively, of a region essential for HV propagation. Also new is a complementation cell line comprising a DNA fragment coding for a recombinase.
Patent PT-857060-E (PT)
Inventor: WINTER GERHARD
IPC: A61K47/18
Filed: 1996-10-24
Abstract: The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.
Patent PT-920312-E (PT)
Inventor: PFAHL MAGNUS
IPC: A61K8/42
Filed: 1997-07-08
Abstract: PCT No. PCT/US97/11564 Sec. 371 Date Apr. 14, 1999 Sec. 102(e) Date Apr. 14, 1999 PCT Filed Jul. 8, 1997 PCT Pub. No. WO98/01132 PCT Pub. Date Jan. 15, 1998The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especially androgen-independent prostate cancer, skin cancer, pancreatic carcinomas, colon cancer, melanoma, ovarian cancer, liver cancer, small cell lung carcinoma, non-small cell lung carcinoma, cervical carcinoma, brain cancer, bladder cancer, breast cancer, neuroblastoma/glioblastoma, and leukemia. Also, the invention relates to novel adamantyl or adamantyl group derivative compounds which are useful as active agents for the treatment or prevention of keratinization disorders and other dermatological conditions, and other diseases.
Patent PT-872454-E (PT)
Inventor: SCOTT GARRETT L
IPC: C03B7/094
Filed: 1998-04-09
Abstract: Apparatus for forming a cased glass stream having an inner core of glass surrounded by an outer glass casing, includes (i) means for delivering core glass from a first source through a first orifice 22, (ii) means forming a second orifice 28 vertically below the first orifice with a chamber 30 surrounding the second orifice and communicating with the second orifice through a gap between the first and second orifices and (iii) means for delivering casing glass from a second source to the chamber such that glass flows by gravity through the orifices to form the cased glass stream. The first and second orifices are carried by an orifice housing assembly 44 with means for moving the assembly into seating engagement against the means for delivering core and casting glass so as to form an area seating engagement. The orifice housing assembly further includes a fluid manifold 50 mounted on the housing assembly and having inlet means for connection to a source of cooling fluid and outlet means 58 directed toward the area 59,60 of seating engagement between the assembly and the means for delivering core and casing glass for cooling the area and thereby reducing leakage of glass between the housing assembly and the means for delivering core and casing glass. Also claimed is an orifice housing assembly for an apparatus for forming a cased glass stream. Also claimed is a method of cooling the area of seating engagement between the orifice housing and the means for delivering streams of core and casing glass.
Patent PT-1021184-E (PT)
Inventor: GIUSEPPE LISI
IPC: A61K47/34
Filed: 1998-10-06
Abstract: Use of flunarizine, a calcium channel blocking agent known for use as cerebral and peripheral vasodilator, in the treatment of glaucoma by topical administration. Differently from other calcium channel blockers already tested for use as antiglaucoma agents, flunarizine is highly active in lowering the intraocular pressure when administered by the topical ophthalmic route. The invention also comprises anti-glaucoma preparations containing flunarizine, or combinations of flunarizine with beta-blockers such as timolol.
Patent PT-1093336-E (PT)
Inventor: LAURENCEAU REMY
IPC: A23K1/18
Filed: 1999-07-05
Abstract: The invention concerns the use of calcium L-pidolate for obtaining an agent improving the quality of eggshells and a composition capable of being administered to laying hens. Said composition is characterized in that it contains as active element for improving the quality of eggshells, in particular firmness and appearance, at least calcium L-pidolate. The invention is applicable to poultry farming.
Patent PT-1187766-E (PT)
Inventor: BOLDIZSAR ISTVAN
IPC: A23L3/16
Filed: 1999-06-23
Abstract: The invention relates to an apparatus and method for heat-treatment of foodstuffs in a plastic container, in a way that the plastic container is sealed after being filled with foodstuffs and poured on, but two pipes are lead inside the container in order to let the pouring liquid being circulated. These pipes are connected through a pump to the secondary circuit of a heat exchanger. Providing warm water or steam on the primary cicuit the pouring liquid warms up simultaneously in the container, pump, pipes and heat exchanger. Providing cold water on the primary circuit of the heat exchanger the food product in the container is cooled down. After the pasterization or sterilization the pipes are removed and the container is sealed again precluding the possibility of reserve infection.
Patent PT-1079860-E (PT)
Inventor: SVENSSON TORGNY
IPC: A61P37/04
Filed: 1999-05-28
Abstract: A 5- or 6-nicotinyl-linker-carrier protein compound and immunogen having formula (a) wherein X is -NH-CO- or NH- or -C=C- or -C=C- or CH2-; Y is -(CH2)k- or -(CH2)m-C6H10-(CH2)n- or (CH2)m-C6H4-(CH2)n- when Z is -NH-, with the proviso that X is not -NH-CO- when Y is (CH2)5 and Z is -NH-, and X is -NH-CO- or -C=C- or -C=C- or CH2-, Y is -(CH2)m-C6H10-(CH2)n- or -(CH2)m-C6H4-(CH2)n-, when Z is -CO-, and X is -C=C- or -C=C-, Z is -CO-, when Y is (CH2)k-, is disclosed. The compound may be used as a medicament, suitably in the form of a pharmaceutical composition. Additionally, a method of prophylactic and/or therapeutic immunological treatment of nicotine dependence from tobacco products to achieve harm reduction is described.
Patent PT-1101294-E (PT)
Title: Gated transmission in control hold state in cdma communication system
Inventor: KIM YOUNG-KY
IPC: H04W52/04
Filed: 1999-07-28
Abstract: A base station and a mobile station for a CDMA communication system intermittently exchange data on a power control group unit or time slot unit in a control hold state to minimize interference. To this end, during channel transmission, the system intermittently transmits a reverse pilot channel signal in the control hold state; upon activation of a reverse dedicated control channel, transmits a normal pilot channel signal which is first generated after activation of the reverse dedicated control channel; and then transmits the reverse dedicated control channel.
Patent PT-1109731-E (PT)
Inventor: HEIJDEN LAMBERTUS GERARDUS P V
IPC: B65D33/06
Filed: 1999-08-17
Abstract: A container (1) for storing and dispensing fluid material, in particular liquid detergents or the like, comprises a flexible collapsible storage portion (4) for storing the fluid material, and a dispensing portion (5) in communication with the storage portion in order to dispense the fluid material from the storage portion in a controlled manner. The storage portion has a substantially rectangular rounded shape. One side (7) thereof contains the dispensing portion. The dispensing portion (5) is pivotally connected to the edge (6) of said one side (7) of the storage portion (4), which slopes away inwardly from the dispensing portion in order to accommodate the folded-in dispensing portion.The invention also includes a combination package which comprises said container (1) and an outer cover (2, 2'). The outer cover has a rectangular shape and includes walls (14, 15) fitting around the filled container and having a portion allowing the passage of the dispensing portion when in use. The folded-in dispensing portion is accommodated between said one side (7) of the container (1) and the adjacent wall (14) of the cover (2, 2').
Patent PT-1155812-E (PT)
Inventor: ORIVE CANTERA ISAAC
IPC: F15B1/02
Filed: 1999-09-30
Abstract: The gas cylinder is of the type used for example in punching installations or tools, and comprises two hermetic and independent chambers (7) and (8), the first placed axially to the corresponding rod (6) and the latter placed annularly and externally, with said two chambers externally communicated through branches (16) and (17) which end in a common chamber (14) of a pressure accumulator (11), in which is defined a second chamber (13) which can be charged with nitrogen and is provided with a movable piston (12) for the filling and corresponding pressure balancing between chambers (14), (7) and (8). Ana electrovalve (18) can be closed at will after attaining the pressure balance between said three chambers (14), (7) and (8), preventing rod (6) from recovering its original position after the force exerted on it during operation ceases. <IMAGE>
Patent IE-820115-L (IE)
Title: Modifying a binary word
IPC: G06F17/10
Filed: 1982-01-20
Abstract: In the method of attenuating or amplifying digital signal values as described herein the desired modification is realized in two steps. A coarse attenuation or amplification in steps of 6 dB is effected by shifting the digital word to be modified into a shift register (R), after which fine amplification is realized by adding the word, which is attenuated by shifting it a number of times, to the word thus shifted. Furthermore, a device for carrying out said method is described, in which the signal processing section only comprises one shift register (R) and an adding circuit (AD), the additional shift being achieved by means of the wiring between the said shift register (R) and the adder circuit (AD), so that no further signal-processing registers are required for carrying out the said cumulative addition.
[US4566076A]
Patent IE-34057-L (IE)
Title: Gel filteration.
IPC: A23C9/148
Filed: 1970-03-16
Abstract: 1307899 Recovering dissolved protein E C SWANSON 17 March 1970 [18 March 1969] 12797/70 Heading C3H A process for the recovery of dissolved protein from an aqueous solution also containing soluble material having a lower molecular weight than said protein consists of the consecutive steps of introducing said solution as a feed into a bed of molecular sieve material having pores of a size permitting the penetration only of molecules smaller than said protein, said bed having a thickness of from 10 to 100 millimetres, the ratio of the total volume of said solution to the volume of said bed being above 25% and no more than 65%, eluting said protein from said bed while entrapping molecules smaller in size than said protein in said molecular sieve material and recovering the protein-containing eluate. The feed may be skim milk, whey, yeast, animal blood, soy whey or fermentation media. A molecular sieve comprising crosslinked dextran having an exclusion limit between 5,000 and 30,000 molecular weight may be used.
[GB1307899A]
Patent IE-810433-L (IE)
Title: A specific cleavage linker
IPC: C07H21/04
Filed: 1981-02-27
Abstract: The present invention is based upon a general principle of providing specific olingonucleotide segments (<<linkers>>, herein) to be attached in sequence to a cloned DNA coding segment. The linkers of the present invention confer desired functional properties on the expression of the protein coded by the coding sequence. Using linkers of the present invention, the desired protein may be expressed either as a fusion or non-fusion protein. A linker coding for an additional sequence of amino acids may be attached, the sequence being chosen to provide properties exploitable in a simplified purification process. A linker coding for an amino acid sequence of the extended specific cleavage site of a proetolytic enzyme is provided, as well as specific cleavage linkers for simple specific cleavage sites.
[EP0035384A2]