baber/WOPTO huggingface dataset:
Patent PT-1020454-E (PT)
Title: Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof
Inventor: MATSUMOTO KOICHI
IPC: C07D277/56
Filed: 1999-06-18
Abstract: The present invention provides a technique of selectively producing a desired polymorph of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid.  The present invention also provides a method of producing various polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, which comprises crystallizing under the conditions defined by a specific temperature and a composition of a mixed solvent of methanol and water, and polymorphs obtained by the method.  The present invention further provides a method of producing the other polymorphs or amorphous compounds by drying a specific polymorph under a reduced pressure with heating, and the other polymorphs or amorphous compounds obtained by the method.
Patent SG-121292-G (SG)
Title: Ejecting latch for electrical connectors
IPC: H01R13/629
Filed: 1992-11-25
Abstract: An electing latch (40) selectively holds an electrical connector member (80) to a header member (20) or ejects the connector member (80) from the header member (20). The latch (40) is easily accessible for operation even if several connectors are mounted very close together.
Patent IE-820222-L (IE)
Title: Tricyclic pyrroles
IPC: C07D207/16
Filed: 1982-02-01
Abstract: 1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-ones have been found to provide excellent protection for the stomach and intestines of warm-blooded animals. They are useful for the treatment and prophylaxis of such maladies as gastritis, acute and chronic ulcus ventriculi and hyperacid gastric irritation. The compounds are administered enterally or parenterally, usually in a standard dosage form. The disclosure includes key intermediates, methods of synthesis, compositions and use.
[US4363816A]
Patent IE-43703-L (IE)
Title: Azetidinones and cephalosporins obtained therefrom.
IPC: C07D501/10
Filed: 1976-02-19
Abstract: The invention concerns a process for the manufacture of 7 beta -amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted- amino-crotonic acids and solvolyzing the enamino group in the resulting 7 beta -acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.
[US4110533A]
Patent IE-33762-L (IE)
Title: Adamantylcarboxamidophenylacetic acid derivatives
IPC: A61K31/165
Filed: 1970-03-25
Abstract: 1310606 2 - (1 - Adamantylcarboxamido)- phenylacetic acids CIBA-GEIGY AG 25 March 1970 [26 March 1969] 14461/70 Heading C2C Novel 2 - (1 - adamantylcarboxamido)- phenylacetic acids of the general formula wherein one of R 1 and R 2 is a hydrogen, fluorine, chlorine or bromine atom or a C 1-4 alkyl, C 1-4 alkoxy or trifluoromethyl group and the other is a hydrogen atom, or both R 1 and R 2 are C 1-4 alkoxy groups, and R 3 and R 4 are each a hydrogen atom or a C 1-4 alkyl group, and, when R 4 is a hydrogen atom in said formula, pharmaceutically acceptable salts thereof with bases are prepared by reaction of a 2-amino-phenylacetic acid of the general formula with an acylating agent containing a 1-adamantyl-carbonyl group and, when in the product R 4 is a hydrogen atom, optional esterification or salification of the product, or, when in the product R 4 is a C 1-4 alkyl group, optional hydrolysis of the product to give the corresponding free acid or a salt thereof, the latter optionally being converted to the free acid. 2 - Amino - phenylacetic acid esters of the second general formula above wherein R 4 is a C 1-4 alkyl group are prepared by esterification of the corresponding 2-nitro-phenylacetic acid and reduction of the resulting 2-nitro-phenylacetic acid ester. Methyl 2-(2-nitro-4-trifluoromethylphenyl)propionate is prepared by reaction of methyl 2-nitro-4-trifluoromethylphenylacetate with methyl iodide in the presence of sodium hydride. Methyl 2-(2-nitro-4-trifluoromethylphenyl)-hexanoate is prepared analogously from 1 - bromo - n - butane. 4 - Methyl - 2 - nitrophenylacetic acid is prepared by reaction of 3- nitro-4-chlorotoluene with diethyl malonate in the presence of sodium, followed by ethanolic potassium hydroxide solution. 5 - Fluoro - 2- nitrophenylacetic acid is prepared by acid hydrolysis of 5-fluoro-2-nitrophenylacetonitrile. Pharmaceutical compositions having antiinflammatory activity comprise, as active ingredient, a 2 - (1 - adamantylcarboxamido)- phenylacetic acid of the first general formula above or, when R 4 is a hydrogen atom in said formula, a pharmaceutically acceptable salt thereof with a base, together with a pharmaceutically acceptable diluent or carrier therefor, and may be administered orally.
[GB1310606A]
Patent IE-43216-L (IE)
Title: Lubricating greases
IPC: B01J19/06
Filed: 1976-03-15
Abstract: A process for thickening an organic liquid, particularly useful in the manufacturing of lubricant greases, comprises; mixing the liquid with a metal sulphonate and possibly a volatile organic solvent, and then heating and/or grinding the resulting mixture.
[US4310428A]
Patent IE-36346-L (IE)
Title: 3-heterocyclylthiomethyl cephalosporins
IPC: C07D249/04
Filed: 1972-05-02
Abstract: 1392241 Cephalosporins R & L MOLECULAR RESEARCH Ltd 10 May 1972 [11 May 1971 (2)] 21737/72 Heading C2C The invention comprises compounds of the Formula I wherein n is 0 or 1 and R represents groupings II, III or IV and non-toxic, pharmaceutically acceptable salts thereof. A process for the preparation of compounds of Formula I or non-toxic, pharmaceutically acceptable salts thereof comprises reacting a compound of Formula V or a salt or an easily hydrolysed ester thereof with an acid of Formula VI wherein B is a blocking group, or with its functional equivalent as an acylating agent for a primary amino group, and subsequently removing the blocking group. A pharmaceutical composition comprises as active ingredient a compound of Formula I or a non-toxic, pharmaceutically acceptable salt thereof in conjunction with a physiologically acceptable exeipient. A method of treating animals; exeluding human beings, to cure them of diseases caused by gram-positive and gram-negative bacteria comprises administering to the animal an effective amount of a compound of Formula I or a non-toxic, pharmaceutically acceptable salt thereof. Starting materials are prepared according to the following schemes
[GB1392241A]
Patent IE-35317-L (IE)
Title: Diagnosing faulty semiconductor devices
IPC: G01R31/311
Filed: 1971-05-31
Abstract: A system is provided for diagnosing and repairing electronic assemblies which include a plurality of semiconductor devices interconnected in parallel, wherein at least one of the devices is faulty. Radiant energy is directed onto each of the devices successively and the response of each device to the radiant energy is noted. When a device causes a response dissimilar from the others it is identified as a faulty device and replaced.
[US3702437A]
Patent IE-43462-L (IE)
Title: Substituted tetranorprostaglandins
IPC: C07C401/00
Filed: 1976-04-09
Abstract: 11-Desoxy-16-aryloxy- omega -tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
[US4157341A]
Patent IE-44828-L (IE)
Title: Assisting pile driving
IPC: E02D7/00
Filed: 1977-04-29
Abstract: An apparatus and method of assisting the driving of a hollow pile into soil by electro-osmosis in which electrical direct current is directed downwardly through the inside of the pile, out the bottom of the pile, and up the outside of the pile whereby water on the inside of the pile moves through the soil thereby making the pile easier to drive into the soil. The method includes insulating an electrically conductive pile preferably on the inside with an electrical non-conductor and placing water inside of the hollow pile. An electrical circuit having a d-c power source, and an anode and cathode is provided in which the anode is placed in the water inside of the hollow pile and the cathode is placed outside of the hollow pile and in electrical communication with the outside of the electrical conductive pile whereby an electrical circuit is formed between the anode and cathode through the water in the inside of the pile and through the bottom of the pile. When electrical power is supplied to the circuit, water will move down the inside of the pile and up the outside of the pile and into the soil adjacent the pile making the pile easier to drive through the soil. In addition, after the pile has been driven, the current flow may be reversed through the electrical circuit for reducing the water content of the soil adjacent the pile thereby increasing the load bearing strength of the soil.
[US4046657A]
Patent IE-890873-L (IE)
Title: Biologically Active Material Characterised by Catabolic Activity Generally Associated with Cachexia Inducing Tumours, Preparations, Production and Uses Thereof
IPC: A61K35/12
Filed: 1989-03-20
Abstract: A biologically active lipolytic factor having an average molecular weight substantially less than 5000 daltons and comprising active molecular species having molecular weights of about 3000 daltons, 1500 daltons and 700-800 daltons is disclosed. The factor can be isolated, using chromatographic methods, from cachexia-inducing tumours, cultures of tissue cells of cachexia-inducing tumours especially cultures of a MAC16 tumour cell line, or from body fluids such as serum or urine of mammals bearing cachexia-inducing tumours. Cancer diagnostic applications in relation to human individuals are described as well as uses for screening and identifying potential anti-cachetic and/or antitumour therapeutic agents.
Patent IE-39237-L (IE)
Title: Azolyl - amidines
IPC: A01N37/52
Filed: 1974-04-26
Abstract: New azolylamidines of the formula WHEREIN N IS AN INTEGER FROM 0 TO 5, R1 is halogen, alkyl, alkoxy, alkylthio, haloalkoxy, haloalkylthio, halophenoxy or haloalkyl; R2 and R3, independently of one another, are each hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkoxy or alkoxycarbonylalkyl, of, preferably not more than 7 carbon atoms; or taken together, represent a lower alkylene bridge which can be interrupted by one or more hetero-atoms; and Az represents an azolyl radical selected from imidazol-1-yl, pyrrol-1-yl, pyrazol-1-yl, 1,2,4-triazol-1-yl, 1,2,4-triazol-4-yl or 1,2,3-triazol-1-yl, AND THEIR SALTS ARE OUTSTANDINGLY EFFECTIVE HERBICIDES SHOWING PARTICULARLY SELECTIVE ACTION.
[US3993469A]
Patent IE-880976-L (IE)
Title: Human tumour-associated antigen
IPC: C07K16/00
Filed: 1988-03-31
Abstract: A human carcinoma-associated antigen which has an apparent molecular weight of about 43,000 and an isoelectric point in the range of about 5.4-6.2, and which has at least one epitope which is reactive with a monoclonal antibody produced by the human hybridoma cell line B9165 (ECACC 87040201), or an analogue thereof, may be used as a diagnostic or therapeutic agent, e.g. for the diagnosis or treatment of human carcinoma. An antibody raised against this antigen may similarly be used for diagnostic or therapeutic purposes.
[EP0285173A2]
Patent FI-824060-L (FI)
Inventor: NILSSON HANS GOESTA BERTIL
IPC: E21B31/107
Filed: 1982-11-25
Abstract: An attachment for a percussive rock drilling machine (12) of the kind being displaceable along a feed beam (14) by a feeding motor. The attachment (15) is arranged for enabling withdrawal of drill steels (16) which are stuck in the drilled hole. The attachment (15) comprises a spring housing (17) which contains a compressive spring (22) and a stopping member (23), said housing being suspended by flexible means (26. 27) from a yoke-shaped member (18) coupled on to the drilling machine body (19). The stopping member (23) is arranged to abut against a coupling sleeve (32) or the like on the drill steel (16). When retracting the drilling machine (12) by said feeding motor and starting the ordinary percussive action the impacts directed downwards will be transformed to impacts directed upwards which loosen and withdraw the stuck drill steel (16).
Patent IE-45095-L (IE)
Title: Dipeptide derivatives
IPC: A61P29/00
Filed: 1977-06-15
Abstract: The present disclosure relates to dipeptide derivatives. The novel compounds are useful as elastase inhibitors.
[US4176116A]
Patent IE-37928-L (IE)
Title: Morpholine derivatives.
IPC: A61P25/26
Filed: 1973-07-19
Abstract: The disclosure relates to new 2-(substituted anilino)-methylmorpholine derivatives which possess sedative activity, to processes for the manufacture of the said morpholine derivatives, and to pharmaceutical compositions containing them. Typical of the morpholine derivatives disclosed is 2-(3-methoxyanilino)methylmorpholine.
[US3974156A]
Patent IE-781248-L (IE)
Title: Container for drill bits or the like
IPC: B25H3/00
Filed: 1978-06-21
Abstract: The container for twist drills has a receiving part (14) connected to a base part (10) and a lid part (15) in an articulated manner. At its bottom narrow side, the lid part (15) is provided with a recess (18) by which the lid part (15) can be pivoted by more than 270 DEG about the base part (10) in order to serve as the standing part of the container. A catch (21) on the lid part causes the receiving part to also swing out automatically when the lid part is opened up, so that the twist drills are immediately ready to hand. <IMAGE>
[CH630837A5]
Patent IE-37953-L (IE)
Title: Foamed synthetic plastics laminate
IPC: B32B5/32
Filed: 1973-07-27
Abstract: 1376038 Laminated foam panels IMPERIAL CHEMICAL INDUSTRIES Ltd 25 July 1973 [18 Aug 1972] 38623/72 Heading B5N In the manufacture of laminates by in situ foaming to form a rigid synthetic plastics core between facing layers, at least one of the facings is provided with minute perforations to permit the escape of air and gases from the foam through the facing. The perforations may be preformed or may be formed as the facing is fed to the laminating stage. Suitable facing materials are specified.
[GB1376038A]
Patent IE-851299-L (IE)
Title: Producing mineral fibres by blast drawing.
IPC: C03B37/06
Filed: 1985-05-23
Abstract: In the production of bonded mineral fibre wool, binder is injected in the chute (16) onto the fibres, as a result of which there is a tendency for the fibres to adhere to the walls of the chute (16) and to form encrustations due to binder becoming cured in the course of time. To avoid such encrustations, which can cause production shortfalls, the circumferential walls (18, 20) of the chute are constructed as jacketed walls and are cooled by passing cooling liquid in the hollow space (30) between the inner and outer surface portions (28, 29). It has been found, surprisingly, that as a result no solid encrustations can form even over prolonged periods, since temporarily adhering fibres cannot in fact become adhesively bonded due to insufficient curing of the binder at the low temperatures, but are continuously removed from the wall again. In contrast to the permanent cleaning of the chute walls, for example in the form of rotary walls, not only is the considerable expenditure in terms of investment and maintenance and/or unforeseeable plant shutdowns avoided, but also there is obtained dimensionally accurate sealing of the circumferential walls (18, 20) of the chute (16), so that there is no occurrence of fibre losses or attraction of unwanted air.
[US4698085A]
Patent IE-791381-L (IE)
Title: Stablizing spinning solutions
IPC: D01F6/18
Filed: 1979-08-08
Abstract: The invention relates to a process for the stabilization of a spinning solution of an acrylonitrile polymer and a solvent which comprises adding from 0.005 to 0.5% based on the quantity of polymer of at least one stabilizer selected from a polyfunctional phosphonic acid, a phosphonocarboxylic acid or a polymer containing phosphonic acid and/or carboxyl groups to the spinning solution as well as to such stabilized spinning solutions.
Patent IE-44450-L (IE)
Title: Osmotically driven dispenser
IPC: A61K9/00
Filed: 1976-08-19
Abstract: 1511614 Osmotically driven dispenser ALZA CORP 13 Aug 1976 [8 Sept 1975] 33833/76 Heading A5B [Also in Division Bl] An osmotically driven dispenser for dispensing an active agent composition to an environment that contains a fluid in which the active agent composition is soluble comprises an inner core formed of the active agent composition, an outer wall surrounding the core that is permeable to the fluid and substantially impermeable to the active agent composition and an outlet passageway in the wall through which the active agent composition in solution is dispensed and is characterised in that the core is made of a microporous material containing the active agent composition. Reference has been directed by the comptroller to Specification 1415210
[GB1511614A]
Patent IE-881961-L (IE)
Title: Drying foodstuffs
IPC: A23B5/02
Filed: 1988-06-28
Abstract: A method of drying a water-containing foodstuff or beverage at a temperature above ambient, is characterised by incorporating trehalose into the foodstuff or beverage which is to be dried.
Patent IE-44293-L (IE)
Title: N-[4-(2-oxo-1-benzimidazolyl)piperidino] alkylbenzamide¹derivatives
IPC: A61P1/08
Filed: 1976-09-06
Abstract: The compounds correspond to the formula: <IMAGE> in which R represents hydrogen or a C1-C3 alkyl, n represents the number 2 or 3 and X represents hydrogen, fluorine, chlorine or bromine or a methoxy, trifluoromethyl, nitro or amino radical. They are prepared by reaction of a 4-[3-R-1,3-dihydro-2-oxo-1-(2H)-benzamid-azolyl]-1-piperidine-ethanami ne or -propanamine with a halide of a para-X-benzoic acid. The ethanamine or propanamine involved can be obtained by reaction of a 4-[3-R-1,3-dihydro-2-oxo-1-(2H)-benzamid-azolyl]piperidine with an N-haloethylphthalimide, then treatment of the intermediate product formed with hydrobromic acid in acetic medium and basification. The compounds I and their salts with acids have an antiemetic action and are free of psychotropic properties; they can be used in the treatment and the prevention of cases of vomiting and nausea.
[CH614440A5]
Patent IE-891987-L (IE)
Title: Neurokinin a antagonists
IPC: C07K1/04
Filed: 1989-06-19
Abstract: Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.
[EP0347802A2]
Patent IE-40090-L (IE)
Title: Combating weeds
IPC: C07D307/82
Filed: 1974-10-24
Abstract: A herbicidal compsn. contains (a) 2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate and (b) N-phenylcarbamate of 3-ethoxycarbonylaminophenyl and/or N-(3,5-dimethylphenylcarbamate) of 3-methoxycarbonylaminophenyl. Constituents (a) and (b) render undesirable vegetation more susceptible to the action of other constituents. the synergistic effect is esp. useful when the constituents are applied to sugar beet fields. A total of 0.2-8, esp. 1-4 kg/ha of the constituents is used. The ratio of (a) to (b) is pref 1-10:10-1 (1-4:4-1). Herbicidal compsns. usually contain a surfactant and/or a vehicle such as water, an organic solvent or clay. Prefd. surfactants are fatty acid alkyl sulphates, alkylarylsulphonates etc.
[FR2249615A1]
Patent IE-792208-L (IE)
Title: Cephalosporin compounds.
IPC: A61P31/04
Filed: 1979-11-16
Abstract: Cephalosporin antibiotics of general formula <IMAGE> (I) (wherein Y(+) represents a C-attached 1-C1-4alkylpyridinium group) exhibit broad spectrum antibiotic activity with unusually high activity against strains of Pseudomonas organisms as well as high activity against various members of the Enterobacteriaceae. The invention also includes the non-toxic salts, non-toxic metabolically labile esters and 1-oxides of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics.
[US4504477A]
Patent IE-842356-L (IE)
Title: Absorbent product with colour contrasted cover pattern.
IPC: A61F13/472
Filed: 1984-09-14
Abstract: A cover (16, 21) is provided for a body fluid absorbing product which has a pattern of depressed (18), and undepressed areas imposed on its exterior surface (17), which pattern presents a highly visible color contrast between the depressed and undepressed areas. The cover comprises a relatively light colored, relatively opaque outer cover (16) having an interior layer (21) of relatively dark color placed in face-to-face relationship with the interior surface (19) of said outer cover and co-embossed.
Patent IE-802370-L (IE)
Title: Azolylketals
IPC: A01N43/64
Filed: 1980-11-14
Abstract: A description is given of new compounds of the formula defined herein: <CHEM> which display valuable microbicidal properties. The compounds can be used for combatting microorganisms harmful to plants, especially phytopathogenic fungi. The compounds of formula I thus possess a curative, systemic, and preventive action very useful for practical requirements for the protection of cultivated plants, without causing these to suffer any undesirable side effects. In practice, the compounds can be used by themselves or in the form of pesticides.
[EP0029355A1]
Patent IE-883229-L (IE)
Title: Measuring surface quality of a lens
IPC: G01B11/30
Filed: 1988-10-25
Abstract: There is provided a method for measuring the surface quality of a lens, which comprises the steps of directing a beam of substantially collimated electromagnetic radiation of a wavelength in the range 200nm to 2000nm onto the surface of the lens, and measuring the intensity of the specularly reflected light from the surface of the lens.
[EP0366352A1]
Patent IE-893338-L (IE)
Title: Process
IPC: C12N9/70
Filed: 1989-10-17
Abstract: A process for the separation of streptokinase from contaminating proteins in a streptokinase-containing mixture, which comprises treating the mixture with a reducing agent to reduce disulphide bridges in the contaminating proteins to free thiol groups, contacting the mixture with a reagent R-X wherein R is a group capable of reacting with a free thiol group and X is a group R<1> capable of reacting with a free thiol group or is a thiol-containing matrix, and thereafter separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.