baber/WOPTO huggingface dataset:
Patent DE-69609184-T2 (DE)
Inventor: LIVINGSTON ALAN
IPC: C07H21/00
Filed: 1996-05-16
Granted: 2001-02-15
Abstract: Improved methods for solution-phase synthesis of purified short-chain oligonucleotide coupling units, such as dimers, trimers, and tetramers, suitable for use in solution-phase or solid-phase oligonucleotide synthesis are provided. In one embodiment, there is provided methods of preparing a coupled oligonucleotide, YZ, comprising: (a) providing first nucleotidic segments, Y, in solution, each of the first segments comprising one, two, three, four, six or eight nucleosides, and each of said first segments having a reactive functional group, a, which is a phosphoramidite group; (b) providing a plurality of second nucleotidic segments, Z, in solution, each of said first segments comprising one, two, three, four, six or eight nucleosides, each of said second segments having two non-identical reactive functional groups, b and c, which are a secondary alcohol group and a primary alcohol group, respectively; and (c) reacting said first and second segments in solution to produce a first linkage isomer, YZ-b, which retains a residual secondary alcohol group, b, and a non-identical second linkage isomer, YZ-c, which retains a residual primary alcohol group, c; and (d) reacting a mixture of said YZ linkage isomers, or derivatives thereof, with a selective capping reagent, in solution, whereby said residual secondary alcohol group, b, of said YZ-b linkage isomer remains selectively unchanged, and the residual primary alcohol group, c, of said YZ-c linkage isomer is selectively capped.
Patent DE-69623654-T2 (DE)
Inventor: HAEGGBERG JEAN
IPC: C11D17/00
Filed: 1996-12-13
Granted: 2003-05-28
Abstract: Automatic dishwashing detergent compositions comprising phosphate builder and metal-containing bleach catalyst, preferably catalysts containing manganese and/or selected from selected cobalt/ammonia catalysts. Preferred compositions comprise cobalt bleach catalyst having the formula:[Co(NH3)n(M)m(B)b]Tywherein cobalt is in the +3 oxidation state; n is 4 or 5 (preferably 5); M is one or more ligands coordinated to the cobalt by one site; B is a ligand coordinated to the cobalt by two sites; b is 0 or 1 (preferably 0); and when b=0, then m+n 6, and when b=1, then m=0 and n=4; and T is one or more appropriately selected counteranions present in a number y, wherein y is an integer to obtain a charge-balanced salt (preferably y is 1-3; most preferably 2 when T is a -1 charged anion); and wherein further the catalyst has a base hydrolysis rate constant of less than 0.23M-1s-1 at 25 DEG  C. Preferred automatic dishwashing compositions further comprise amylase and/or protease.
Patent DE-69624138-T2 (DE)
Inventor: AGUS PATRIZIO
IPC: C04B41/50
Filed: 1996-12-18
Granted: 2003-08-14
Abstract: A mortar composition for application of a regenerating and protective coating on cementitious materials by means of an airless pump contains cement, aggregate and synthetic resin emulsion in fixed quantities. It is prepared by mixing the ingredients in a cement mixer until a homogeneous, free-running mortar is obtained followed by pouring it into an agitator with low rpm and agitating until complete utilisation.
Patent DE-69627014-T2 (DE)
Inventor: LOW COLIN
IPC: H04L29/12
Filed: 1996-12-11
Granted: 2003-11-27
Abstract: Traditional IN (Intelligent Network) services in a PSTN use service logic and data that is accessible for use only by the PSTN, though provision may be made for users to change certain controlled parameters of the services. The present system has the service logic and data placed on a server (51) accessible by the service control subsystem of a telephone network using a URI. Thus, in one embodiment, service logic and/or data is placed on an HTTP server (51) and accessed by the service control subsystem over the Internet (50) using a corresponding URL. The server (51) may also be accessible to the general public to enable the service resource items to be used by anyone in setting up a call.  <IMAGE>
Patent DE-69628574-T2 (DE)
Inventor: PALUMBO GIANFRANCO
IPC: A61F13/15
Filed: 1996-08-20
Granted: 2004-04-29
Abstract: An absorbent sanitary article, for example a sanitary pad, comprises a fluid absorbing core (4), a first fluid receiving layer (1) positioned on one side of the fluid absorbing core, and spaced therefrom over at least part of its surface, by eleasticity, to define a void between the core and the first fluid receiving layer. A second fluid receiving layer (5) is positioned on the opposite side of the core to the first fluid receiving layer, the second fluid receiving layer being in fluid communication with the core and with the first fluid receiving layer.
Patent DE-69633018-T2 (DE)
Inventor: AMIT K MITRA
IPC: A61K31/00
Filed: 1996-11-14
Granted: 2004-12-09
Abstract: Disclosed are thyroid hormone preparations useful in pharmaceutical applications. These preparations are disclosed to contain thyroxine drugs in combination with an inorganic salt, a carbohydrate having a molecular weight of greater than 500, and glycine. The preparations are also disclosed to have a free water content less than 4.5% by weight of the preparation. Also provided are compositions containing a reduced carbohydrate, a water soluble polysaccharide, or galactose. The preparations have improved stability wherein they are provided as being stable to the extent that substantially no potency loss is measured when the preparation is stored at 40 DEG  C. and 75% relative humidity for 3 months.
Patent DE-69633345-T2 (DE)
Inventor: PARK MAN KI
IPC: A61K36/23
Filed: 1996-11-20
Granted: 2005-09-22
Abstract: The present invention relates to a vasodilating composition comprising ginsenoside Rg3 and/or Rg5, one of the saponin components of ginseng, as an active ingredient. Since ginsenoside Rg3 and Rg5, the active ingredient of the composition according to the present invention, exhibit an endothelium-dependent vasodilation and do not destroy endothelium cells contrary to the ordinary saponins, they can be used safely without any side effect such as hemolysis or toxicity against fishes. Ginsenoside Rg3 and Rg5 are hardly contained in ginseng plants such as fresh ginseng, white ginseng, etc., and contained in a minor amount in red ginseng. The contents of ginsenoside Rg3 and Rg5 are increased greatly by heating ginseng plant for 0.5 to 20 hours at a high temperature of 110 to 180  DEG C.
Patent DE-69708108-T2 (DE)
Inventor: PEREGO LUCIANO
IPC: G11B7/26
Filed: 1997-11-21
Granted: 2002-03-14
Abstract: A feeding magazine (3) is set to feed constantly a machine (1) for processing optical discs (2). The discs are carried from the feeding magazine (10) on respective feeding supports (18) aligned vertically. Subsequently, the discs (2) are simultaneously drawn from the feeding supports (18) by means of a transport arm (35) and inserted thereby into a work station (4). Once the processing of the discs (2) is complete, the transport arm (35) carries the discs onto respective outlet supports (25) vertically aligned and comprised in an outlet station (5). The processed discs (2) are then stored in an outlet magazine (29). <IMAGE>
Patent DE-69713582-T2 (DE)
Inventor: CHEN B
IPC: C07C205/57
Filed: 1997-03-25
Granted: 2003-01-09
Abstract: The present invention relates to a class of compounds represented by the Formula I   <IMAGE>   or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the  alpha v beta 3 integrin.
Patent DE-69715835-T2 (DE)
Inventor: GUARINI GIUSEPPE
IPC: F25D21/00
Filed: 1997-07-22
Granted: 2003-05-28
Abstract: A method (200) of controlling the defrosting cycles of a battery in a heat-pump system, comprising the steps of detecting (207) a first value indicative of a state parameter relating to a refrigerant fluid used in the system, comparing (239) the first value with a threshold value, and performing (245) a defrosting cycle in dependence on a result of the comparison, includes the steps of determining (221-227) a second value correlated with a maximum value of the first value and modifying (230) the threshold value in dependence on the second value. <IMAGE>
Patent DE-69718244-T2 (DE)
Inventor: GUZAEV ANDREI
IPC: C07F9/24
Filed: 1997-07-02
Granted: 2003-06-05
Abstract: Phosphoramidite building blocks according to the following formula 1 are used for phosphorylating oligonucleotides, preferably at the 5'- or 3'-terminus. The building blocks include phosphoramidite compounds according to formula 1: <CHEM> wherein DMTr is a 4,4'-dimethoxytrityl group; R1 is an electron withdrawing group; R2 is an electron withdrawing group which may be the same or different from the R1 group; R3 is an alkyl group; and R4 is an alkyl group which may be the same or different from the R3 group. Preferred electron withdrawing groups include -CO2Me groups, -CN groups, -CON(Me)2 groups, and -CONHMe groups, wherein Et represents an ethyl group and Me represents a methyl group. One preferred alkyl group is an isopropyl group. <IMAGE>
Patent DE-69719335-T2 (DE)
Inventor: HJERTMAN BIRGER
IPC: A61M5/145
Filed: 1997-06-18
Granted: 2003-10-16
Abstract: An injection device comprising a) a housing, b) a cartridge containing a preparation or precursor components for the preparation and having a front part and a rear part defining a general cartridge axis, an outlet for the preparation arranged at the front part and at least one movable wall arranged between the front part and the rear part, a displacement of which wall causes the preparation to be moved towards or expelled through the outlet, c) a piston rod, having a first end and a second end, at least partly contained within the housing and being operable to engage and displace the movable wall at its first end and d) actuating means within the housing arranged to move at least the rod. According to the invention the device comprises gripping means connected to the housing and arranged to hold the cartridge, or an enclosure therefore, with its front part distal and its rear part proximal to the housing, the actuating means being arranged to move the gripping means so as to move the cartridge, with its rear part leading, relative the housing, locking means able to lock the cartridge against axial movements relative to the housing, hereby defining a locked position for the cartridge, the actuating means being able to move the piston rod between at least one retracted position and at least one extended position, and the relative positions between the piston rod in its retracted position and the cartridge in its locked position being such that the piston rod extends into the cartridge. The invention also relates to a method for operating the device.
Patent DE-69726704-T2 (DE)
Inventor: POIX RENE
IPC: E06B3/66
Filed: 1997-07-31
Granted: 2004-10-07
Abstract: A method of producing a vacuum between two glass sheets to form an insulating glazing. One of the sheets has a hole drilled in its thickness. Spacers are placed between the two glass sheets with the sealing joint being placed around the periphery of the sheets. A vacuum is created between the sheets through the hole which is then closed. The spacers are fixed on one of the sheets by bonding with a mineral compound covering at least the bonding zones on the glass sheet. The second sheet is placed on the spacers and on the peripheral sealing joint. The peripheral sealing and the bonding with the spacers are simultaneously effected by raising the temperature.
Patent DE-69734473-T2 (DE)
Inventor: CONSTANTZ R
IPC: A61J1/00
Filed: 1997-12-12
Granted: 2006-07-20
Abstract: A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.
Patent DE-69737049-T2 (DE)
Inventor: THIRIET FABIEN
IPC: G06F1/00
Filed: 1997-01-16
Granted: 2007-08-16
Abstract: A central processor unit (1) has a memory with zones (3,4). In a first memory zone (3), a series of executable functions are stored directly by the central unit (1). The first zone (3) is protected. The program is stored in a second memory zone (4) in the form of a series of instructions executable by the CPU, or the function contained in the first memory zone (3) is activated. The functions of the first zone of memory are executable at pre-determined addresses and besides activation of the functions of the first memory zone, the instructions of the second memory zone are exclusively executable in the second memory zone.
Patent DE-69805252-T2 (DE)
Inventor: WALCH MARTIN
IPC: A01B63/22
Filed: 1998-01-30
Granted: 2002-11-14
Abstract: PCT No. PCT/FR98/00172 Sec. 371 Date Oct. 5, 1998 Sec. 102(e) Date Oct. 5, 1998 PCT Filed Jan. 30, 1998 PCT Pub. No. WO98/33371 PCT Pub. Date Aug. 6, 1998A method and device for automatically adjusting the lightening of a working unit (U) of a machine by use of a hydraulic ram (57) associated with a hydropneumatic accumulator (67). Use is made of a second hydraulic ram (58) of which the piston (53), which can move as far as a predetermined position (PP) in the cylinder (C2) and which is detached from the rod (46) of the first hydraulic ram (57), acts directly or indirectly on the latter rod via the oil (O) contained in the first hydraulic ram (57). The working unit (U) is raised and lowered by the second hydraulic ram (58). When raising the working unit (U), the volume of oil in the first hydraulic ram (57) is increased or decreased in such a way that the working unit (U) is always at a predetermined height (HP) at the end of raising travel.
Patent DE-69806270-T2 (DE)
Inventor: MURDOCK O
IPC: A61N1/30
Filed: 1998-12-16
Granted: 2002-10-10
Abstract: An electrode assembly and a method of forming an anhydrous reservoir layer of an electrode assembly in an electrotransport transdermal agent delivery device are provided. The reservoir layer is adapted to be placed in agent-transmitting relation with a body surface and an electrode in electrical contact with a power source and the reservoir layer. The method includes the steps of dissolving a beneficial agent in a solvent, applying the solvent and dissolved beneficial agent to a surface of a hydrophilic polymer filtration membrane, removing the solvent from the surface of the filtration membrane, and disposing the beneficial agent/filtration membrane within the electrode assembly.
Patent DE-69809613-T2 (DE)
Inventor: CENTOFANTI ADRIANO
IPC: C08K5/17
Filed: 1998-02-17
Granted: 2003-09-11
Abstract: A three stages process for the preparation of solid thermoplastic compositions based on polyvinyl alcohol comprising the mixing in a mixer of a first charge, comprising the polyvinyl alcohol and solid plasticizers, with a second charge constituted by one or more hydroxylated organic compounds selected from glycols, glycol ethers and alkanolamines and at least a salt of an alkaline and/or alkaline earth metal, and a third charge containing at least one or more solid polyhydroxylated alcohols, glycols and glycolic ethers, liquid alkanolamines, organic or inorganic mineral acids, hydrated inorganic salts, polymers having a low molecular weight, stabilizers and possible mineral charges, is described.
Patent DE-69821464-T2 (DE)
Inventor: AZZANI JEAN-LUC
IPC: B65D5/42
Filed: 1998-03-30
Granted: 2004-12-02
Abstract: The present invention is directed to a case (1) having six substantially rectangular sides, which comprises top and bottom sides opposing each other, left and right sides opposing each other, and front and back sides opposing each other, further comprising top inner flaps (12) and bottom inner flaps (13), top outer flaps (14) and bottom outer flaps (15), said top inner flaps (12) being disjoined, and said case containing at least two package units disposed in at least one layer, characterized in that, the distance between the top of a package unit and the corresponding internal surface of the case is substantially equal, for all the package units in the uppermost layer, so that said package units substantially equally contribute in carrying the top load, for example when several cases are stacked in a pallet. <IMAGE>
Patent DE-69824557-T2 (DE)
Inventor: SOBRERO GIOVANNI
IPC: A21C15/04
Filed: 1998-06-29
Granted: 2005-06-09
Abstract: Apparatus for cutting shell valves (V) formed in a wafer sheet (C) in which the valves (V) are connected by a substantially flat web (W), cutting means (12) acting parallel to the general plane of the wafer sheet (C) with a relative advance between the wafer sheet (C) and the cutting means (12). The cutting means include a milling element (12) provided with at least one blade (14) capable of an orbital cutting movement on a substantially cylindrical surface. The apparatus also includes positioning means (24) for the wafer sheet in order to realize the said relative advance with the said web (W) substantially tangential to the said cylindrical cutting surface, so that the web (W) is affected by the action of the said at least one blade (14) of the milling element. <IMAGE>
Patent DE-69900924-T2 (DE)
Inventor: MARINO ROBERT
IPC: E01C7/26
Filed: 1999-04-01
Granted: 2002-10-31
Abstract: A method of repairing cracks and apertures in a roadway, including the step of filling the crack (10) or aperture with petroleum emulsion and overlapping (24,26) the crack (10) or aperture with the emulsion to preferably up to one inch or greater beyond the edge of the aperture on each side; applying a layer of an organic, cover blotter material and mounding said cover blotter material to cover substantially the entirety of said petroleum emulsion layer. The emulsion penetrates and softens the pavement surrounding the site. When the emulsion cures, it coagulates with the cover blotter material. The roadway (12) is reopened to allow traffic to pass over the site to further compact and smooth out the roadway repaired surface to eventually form a pliable smooth patch. <IMAGE>
Patent DE-69916212-T2 (DE)
Inventor: GLASBY IAN
IPC: B21B31/04
Filed: 1999-07-19
Granted: 2005-05-19
Abstract: A dynamic position control means for a cluster mill which has a two-part pre-stressed housing in which the two parts are joined by hydraulic cylinders and associated columns. It comprises an actuating means located between the housings of the mill, so as to vary the relative separation or the relative orientation or both of the two halves of the housing during rolling. The actuating means includes at least one hydraulic lifting ram disposed substantially between the two halves of the housing, and ideally four hydraulic lifting rams each ram disposed at the corner position of a rectangular housing. The hydraulic lifting rams are of the doughnut type, encompassing each of the hydraulic cylinder's columns. The dynamic position control means includes position monitoring means, in particular, four position transducers mounted between the four respective corners of the housings. Control means then adjust the actuating means in response to the position monitoring means or other measured data. <IMAGE>
Patent DE-69920243-T2 (DE)
Inventor: NETER WITOLD
IPC: B29C49/06
Filed: 1999-04-20
Granted: 2005-09-22
Abstract: The present invention relates to a multi-stage, post-mold cooling method and apparatus used in conjunction with an injection molding machine having an aggressive cycle time and a high output. The apparatus of the present invention includes a thermal conditioning device/station with cooling tubes for keeping separate the preforms of each batch and effecting cooling of the molded preforms, several separated cooling levels for simultaneously cooling multiple batches of preforms, and internal devices for automatically transferring each batch of molded preforms from one cooling level to the next. In a preferred embodiment, the thermal aconditioning device/station is partially sealed to create a controlled temperature environment for conditioning the molded articles. In another embodiment, the thermal conditioning device/station includes a level for re-heating the preforms.
Patent DE-69923968-T2 (DE)
Inventor: JOHANSON A
IPC: A61B17/00
Filed: 1999-05-27
Granted: 2006-04-06
Abstract: A rivet-like bone anchor has a floating washer at its head that can adapt to an angled bone surface and, thereby, better secure a tissue thereto. The anchor includes a rivet, an expandable sleeve, and a washer. The rivet includes a head and an elongate body having proximal and distal ends, the head being mounted on the proximal end of the elongate body. The expandable sleeve has an inner bore adapted to receive the rivet body. The washer "floats" at a proximal end of the sleeve. As the rivet is inserted into sleeve, the sleeve expands into an interference fit with the bone. The head of the rivet, moreover, forces the floating washer into contact with the tissue at an angle that conforms to that of the underlying bone surface. A deployment tool permits the anchor to be deployed without application of unnecessary counterforce. The tool includes an outer tube, the distal end of which can hold the anchor housing, e.g., via a screw fit. A rod, which is slidably disposed within the bore of the tube, can be used to push the rivet into the expandable sleeve so that the sleeve expands into the bone, so that the floating washer is forced into position against the bone surface, and so that anchor is broken away from the housing. This can be effected, for example, by squeezing the distal ends of the outer tube and the rod together, e.g., in the manner that the end of a syringe is squeezed.
Patent DE-69924089-T2 (DE)
Inventor: KITAMURA KOTA
IPC: C07D211/46
Filed: 1999-12-20
Granted: 2006-04-13
Abstract: A hindered amine compound having the solubility in an acidic solution of 5.0 x 10<-3> eq./liter or less comprising at least two specific organic groups in a specific weight ratio in a molecule, or at least two specific monomeric units, which can be used as a stabilizer of a resin.
Patent DE-69925459-T2 (DE)
Inventor: PFLAUM ZLATKO
IPC: A61P3/06
Filed: 1999-02-17
Granted: 2006-04-27
Abstract: A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which process comprises: clarifying a mycelium broth and concentrating the clarified broth to a lower volume, acidifying of the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, crystallization of the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, and crystallization of the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water. The crystallization steps may also be reverse. The concept of a combination of the specified crystallization steps can also be used for the purification of a crude HMG-CoA reductase inhibitor.
Patent DE-69927099-T2 (DE)
Inventor: ROGATSCHNIG JOHANN
IPC: H01H13/08
Filed: 1999-02-08
Granted: 2006-06-14
Abstract: In an apparatus comprising a housing wall formed with a passage closed by an elastically deformable cover which has a raised portion and comprising switching means arranged behind the cover, a switching function of the switching means can be actuated only when a raised portion is moved into an operating position in which the cover has a recessed shape in the area of the raised portion.