Patent SG-11201909793Y-A (SG)
Title: AMIDE DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS
Inventor: YAMAGISHI TATSUYA
IPC: A61P25/08
Filed: 2018-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2018 (27.12.2018) WIP0 I PCT omit VIII °nolo III 011111110111011101110IImo oimIE (10) International Publication Number WO 2018/235851 Al (51) International Patent Classification: C07D 213/81 (2006.01) A61P 25/22 (2006.01) A61K 31/444 (2006.01) A61P 25/24 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) A61P 1/18 (2006.01) CO7D 239/42 (2006.01) A61P 19/02 (2006.01) CO7D 401/12 (2006.01) A61P 25/08 (2006.01) (21) International Application Number: PCT/JP2018/023412 (22) International Filing Date: 20 June 2018 (20.06.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/522,215 20 June 2017 (20.06.2017) US (71) Applicant: RAQUALIA PHARMA INC. [JP/JP]; 1-21-19 Meieki Minami, Nakamura-ku, Nagoya-shi, Aichi, 4500003 (JP). (72) Inventors: YAMAGISHI, Tatsuya; c/o RaQualia Phar- ma Inc., 1-21-19 Meieki Minami, Nakamura-ku, Nagoya- shi, Aichi, 4500003 (JP). MORITA, Mikio; c/o RaQualia Pharma Inc., 1-21-19 Meieki Minami, Nakamura-ku, Nagoya-shi, Aichi, 4500003 (JP). SHISHIDO, Yuji; c/o RaQualia Pharma Inc., 1-21-19 Meieki Minami, Nakamu- ra-ku, Nagoya-shi, Aichi, 4500003 (JP). YAMAGUCHI, Ryuichi; c/o RaQualia Pharma Inc., 1-21-19 Meieki Mina- mi, Nakamura-ku, Nagoya-shi, Aichi, 4500003 (JP). GA- JA, Norikazu; c/o RaQualia Pharma Inc., 1-21-19 Meieki Minami, Nakamura-ku, Nagoya-shi, Aichi, 4500003 (JP). (74) Agent: 1WATANI, Ryo; KEIHAN Dojima Bldg. 6F, 1-31, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka, 5300003 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: AMIDE DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS [R 2 ~ 0 [ R 3 I I Rya 0 R 5c H )( NI X R 5b R 50 0 (I) (57) : The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.