Patent SG-11201903400W-A (SG)
Title: Anti-edb antibodies and antibody-drug conjugates
Inventor: HOOPER ANDREA THERESE
IPC: A61K47/68
Filed: 2017-10-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 April 2018 (26.04.2018) WIP0 I PCT omit Imlloolm En oimIE (10) International Publication Number WO 2018/073680 Al 0- VEHICLE -0- 0.3 mg/kg EDB-L19-vc-0101 (ADC1) tr 0.75 mg/kg EDB-L19-vc-0101 (ADC1) * 1.5 mg/kg EDB-L19-vc-0101 (ADC1) 0 3 mg/kg EDB-L19-vc-0101 (ADC1) FIG. 5A (51) International Patent Classification: A61K 47/68 (2017.01) A61P 35/00 (2006.01) CO7K 16/32 (2006.01) (21) International Application Number: PCT/IB2017/056093 (22) International Filing Date: 03 October 2017 (03.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/409,081 17 October 2016 (17.10.2016) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). (72) Inventors: HOOPER, Andrea Therese; 52 Woodland Drive, Port Chester, NY 10573 (US). MARQUETTE, Kimberly Ann; 66 Springfield Street, Unit 1, Somerville, MA 02143 (US). SUBRAMANYAM, Chakrapani; 314 Great Pond Road, South Glastonbury, CT 06073 (US). GERBER, Hans-Peter; 21A North Mountain Avenue, Montclair, NJ 07042 (US). MAY, Chad Michael; 80 Church Street, Unit B, Tarrytown, NY 10591 (US). (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ANTI-EDB ANTIBODIES AND ANTIBODY-DRUG CONJUGATES PDX-NSX-11122 Time (Days) Dosed Day 0, 4, 8, 12 1-1 N O 00 1-1 © (57) : The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant f'1 of fibronectin 1 and methods for preparing and using the same. C [Continued on next page] WO 2018/073680 Al MIDEDIMOMOIDEIREEMOOMEIIIIMIONOMMEHOIMI Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))