Patent SG-11201909571S-A (SG)
Title: Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
Inventor: LIU HONG
IPC: C12N5/0783
Filed: 2018-04-24
Abstract: a- Mock -o- CAR caTCR-1 CSR-1 § 2 9 450 - 6 > E E g 300- )- 11, 2 150- 0- 10 15 20 25 30 35 Days post T cell dosing 600 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT omit IIl °nolo Em mil ono oimIE (10) International Publication Number WO 2018/200583 Al (51) International Patent Classification: A61K 35/17 (2015.01) CO7K 16/30 (2006.01) A61P 35/00 (2006.01) CO7K 19/00 (2006.01) C07K 14/725 (2006.01) C12N 5/0783 (2010.01) (21) International Application Number: PCT/US2018/029218 (22) International Filing Date: 24 April 2018 (24.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/490,576 26 April 2017 (26.04.2017) US 62/490,578 26 April 2017 (26.04.2017) US 62/490,580 26 April 2017 (26.04.2017) US (71) Applicant: EUREKA THERAPEUTICS, INC. [US/US]; 5858 Horton Street, Suite 370, Emeryville, California 94608 (US). (72) Inventors: LIU, Hong; 5573 Woodview Drive, El So- brante, California 94803 (US). ZHANG, Pengbo; 4659 Rousillon Avenue, Fremont, California 94555 (US). HO- RAN, Lucas; 2340 Powell Street, #156, Emeryville, Cal- ifornia 94608 (US). XU, Yiyang; 7652 Chestnut Way, Pleasanton, California 94588 (US). STALEY, Binnaz K.; 2408 San Carlos Avenue, San Carlos, California 94070 (US). LIU, Lianxing; 1385 20th Avenue, Apt. 2, San Fran- cisco, California 94122 (US). YUN, Hongruo; 481 Faxon Avenue, San Francisco, California 94112 (US). (74) Agent: QI, Yan; Morrison & Foerster LLP, 755 Page Mill Road, Palo Alto, California 94304-1018 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: CELLS EXPRESSING CHIMERIC ACTIVATING RECEPTORS AND CHIMERIC STIMULATING RECEPTORS AND USES THEREOF FIG. 18 (57) : The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells. [Continued on next page] WO 2018/200583 Al MIDEDIM011010EIRDERI001010111MH11111111111110111111111111 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))