Patent CA-3080492-A1 (CA)
Inventor: RING AARON
IPC: C12N15/24
Filed: 2018-09-06
Abstract: CA 03080492 2020-04-27 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 11111 1 111111 11 111111 1 11 11111 1 111 1111 1 1 11 11111 1111 1 11 11111 1 111 111 11111111111 1 11 1111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/051015 Al 14 March 2019 (14.03.2019) WIPO I PCT (51) International Patent Classification: (74) Agent: SINGH, Pallab et al.; Riverside Law, LLP, Glen-A61K 38/00 (2006.01) C07K 14/54 (2006.01) hardie Corporate Center, 1285 Drummers Lane, Suite 202, A61K 38/20 (2006.01) C12N 15/24 (2006.01) Wayne, PA 1908'7 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/U52018/049648 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 06 September 2018 (06.09.2018) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/554,605 06 September 2017 (06.09.2017) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/652,2'79 03 April 2018 (03.04.2018) US TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: YALE UNIVERSITY [US/US]; Two Whitney (84) Designated States (unless otherwise indicated, for every Avenue, New Haven, CT 06510 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: RING, Aaron; 504 Chapel St., Unite 2, New UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Haven, CT 06511 (US). ZHOU, Ting; 5'79 Prospect Street TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Apt. C, New Haven, CT 06511 (US). FISCHER, Suzanne; EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, 1995 Chapel Street, New Haven, CT 06515 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: INTERLEUKIN-18 VARIANTS AND METHODS OF USE 1. == LAS +14_18R1 ;: ILIBRAP . .1L11> 0 µ= . = -0. . õ. : = : 1-1 -0.5 0.0 0.5 1.0 Apthisttlon Score Adapted from Singer et al., Cell, 2017 kin FIG. 1A 1-1 (57) Abstract: The present invention provides compositions and methods comprising an activator of IL-18 activity for use in therapeutic and non-therapeutic applications. The activator provides IL-18 signaling activity even in the presence of an inhibitory molecule such r=11 as 1L-18BP. [Continued on next page] CA 03080492 2020-04-27 WO 2019/051015 Al I11111 NMI II lIllIl 11111 11111 3E111 I 11111111111111111111 11111 0111 lH 11111111111 0l 1111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: ¨ with international search report (Art. 21(3)) ¨ before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) ¨ with sequence listing part of description (Rule 5.2(a))