Patent SG-11201806968R-A (SG)
Title: Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n- methylmethanamine
Inventor: KIM AERI
IPC: C07D207/48
Filed: 2017-03-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M1111101110101011111 HO 111110111011110011111 100111110111110111011# International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/164575 Al 28 September 2017 (28.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 207/48 (2006.01) A61K 31/40 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7C 55/10 (2006.01) A61K 9/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07C 57/15 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/KR2017/002913 KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 17 March 2017 (17.03.2017) NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, (25) Filing Language: English TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (26) Publication Language: English ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 10-2016-0036081 25 March 2016 (25.03.2016) KR kind of regional protection available): ARIPO (BW, GH, 10-2017-0018336 9 February 2017 (09.02.2017) KR GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: DAEWOONG PHARMACEUTICAL TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, CO.,LTD. [KR/KR]; 244, Galmachi-ro, Jungwon-gu, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Seongnam-si, Gyeonggi-do 13211 (KR). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: KIM, Aeri; 109-1701, 154, Yeongjung-ro, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). _ Yeongdeungpo-gu, Seoul, 07226 (KR). CHO, Kwan Hy- ung; 111, 1902, 156, Hwamyeongsindosi-ro, Buk-gu, Published: Busan, 46525 (KR). — — with international search report (Art. 21(3)) = (74) Agent: YOU ME PATENT & LAW FIRM; 115 Teher- an-ro, Gangnam-gu, Seoul 06134 (KR). = = = = = = = = = = = = 1-1 ir) IN ir) 1 1' 1-1 (54) Title: NOVEL ACID ADDITION SALT OF 1-(5-(2,4-DIFLUOROPHENYL)-1((3- FLUOROPHENYL)SULFONYL)-4- jr: METHOXY-1H-PYRROL-3-YL)-N- METHYLMETHANAMINE 1-1 C (57) : The present invention provides a novel acid addition salt of 1-(5-(2,4-difluoropheny1)- 1 -((3 -fluorophenyl)sulfony1)- el 4-methoxy- 1 H-pyrrol-3 -y1)-N-memylmethanarnine. The above- described acid addition salt can have not only excellent proton 0 pump inhibitory activity, gastric damage inhibitory activity and defensive factor-enhancing effect, but also excellent eradication ,-t activity against H. pylori and thus can be effectively used for the prevention and treatment of gastrointestinal injury due to gastrointestinal track ulcer, gastritis, reflux esophagitis, or H. pylori.