baber/WOPTO huggingface dataset:
Patent PT-2131845-E (PT)
Title: 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide mesylate, hydrates and polymorphs thereof, and formulations comprising these forms
Inventor: MUTZ MICHAEL
IPC: A61K31/5377
Filed: 2008-02-28
Abstract: The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.
Patent PT-2173886-E (PT)
Title: Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
Inventor: VEZINA LOUIS-PHILIPPE
IPC: A61K39/145
Filed: 2008-07-11
Abstract: A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Patent PT-2256999-E (PT)
Title: Radio access network and terminal with robust header compression
Inventor: LEE SO-YOUNG
IPC: H04W80/00
Filed: 2003-08-14
Abstract: A bi-directional packet data transmission system for a packet data transmission between a terminal and a radio access network includes an uplink resource and a downlink resource which are independently set. Memory resources can be effectively managed even in a packet data transmission service with the asymmetrical structure such that the packet amount for the downlink is much greater than the packet amount for the uplink, or the packet amount for the uplink is much greater than the packet amount for the downlink.
Patent PT-658207-E (PT)
Inventor: GREENLAND ANDREW JAMES
IPC: C12N15/60
Filed: 1993-07-29
Abstract: A recombinant plant genome contains a gene cascade such that it is incapable of producing a mature plant but requires the presence of a chemical inducer. The gene cascade includes a gene switch which is inducible by external application of a chemical inducer and which controls expression of a gene product which affects expression of a second gene in the genome. Survival or development of the plant is dependant upon either expression or non-expression of the second gene and application of the inducer, therefore, selects whether or not the plant develops. In one example the second gene encodes a cytotoxic molecule and expression of that gene is fatal to the plant. In another example the second gene encodes a desirable characteristic which may be excised selectively by applying or withholding chemical application. The second gene may be placed under control of a development regulated promoter.
Patent PT-682070-E (PT)
Inventor: GRAHAM ROGER KENNETH
IPC: C08L101/16
Filed: 1994-12-23
Abstract: A melt-processed blend comprises: (A) 70-95 pts.wt. starch; and (B) 5-30 pts.wt. second polymer having an Mw of at least 80000 and contg.: (i) at least 70 pts.wt. units derived from an alkyl, cycloalkyl, hydroxyalkyl(polyalkoxy)alkyl and/or alkyloxy(polyalkoxy)alkyl ester of (meth)acrylic acid; and (ii) up to 25 pts.wt. units derived from a vinyl or vinylidene monomer contg. an amide gp.; and/or (iii) up to 25 pts.wt. units derived from an unsatd. carboxylic acid (anhydride). Also claimed is a film, sheet or injection moulded object prepd. from the blend. Pref. the blend further contains a lubricant, pref. stearic acid; and/or a thermal stabiliser, pref. a hindered phenol. The hydroxyalkyl(polyalkoxy)alkyl or alkyloxy(polyalkoxy)alkyl ester of (meth)acrylic acid is the mono(meth)acrylate ester of a polyalkylene glycol monoalkyl ether or of a polyalkylene glycol. The alkyl ester of (meth)acrylic acid is methyl methacrylate or ethyl acrylate.
Patent PT-835656-E (PT)
Inventor: REIMANN WOLFGANG SIEGFRIED
IPC: A61K31/55
Filed: 1997-09-17
Abstract: Combination preparation contains tramadol (I) (optionally as its salt) and a calcium channel antagonist (II) either in separate formulations or in a single formulation.
Patent PT-803249-E (PT)
Inventor: DIEHL SHERRY LYNN
IPC: A23L1/304
Filed: 1997-04-07
Abstract: Disclosed are drink mix compositions comprising a therapeutically effective dose of an anion exchange resin, and xanthan gum. These compositions may also contain one or more carriers wherein the compositions are in a form mixable with a liquid to form a suspension of the anion exchange resin and xanthan gum.
Patent PT-925065-E (PT)
Inventor: HOPPONEN RAYMOND E
IPC: A61K31/70
Filed: 1997-07-02
Abstract: Water miscible pharmaceutical compositions containing up to about 40% of erythromycin prepared by reaction with acetic acid in a non-aqueous water miscible organic solvent system.
Patent PT-920816-E (PT)
Inventor: O'REILLY ROSEMARY ELIZABETH
IPC: A24D3/04
Filed: 1994-09-26
Abstract: This invention relates to a method which provides in a cigarette filter element a capsule containing a deodoriser. The capsule is resistant to the handling endured before and during smoking, and is ruptured to release or expose the deodoriser after smoking has occurred and upon extinguishing of the smoked cigarette. The deodoriser may comprise neutralising or masking agents, or mixtures of both. <IMAGE>
Patent PT-1005538-E (PT)
IPC: A61K38/43
Filed: 1998-02-05
Abstract: The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a smooth muscle cell. Also provided by the present invention is a method of inducing penile erection in a subject comprising the introduction and expression of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a sufficient number of cells of the subject to induce penile erection in the subject. The present invention also provides a recombinant vector comprising the DNA of or corresponding to at least a portion of the genome of a virus, which portion is capable of directing the expression of a DNA sequence, and DNA encoding a protein involved in the regulation of smooth muscle tone operably linked to the viral DNA and capable of being expressed as a functional gene product in the target cell. Also provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.
Patent PT-1023308-E (PT)
Inventor: FURNEAUX RICHARD HUBERT
IPC: A01N43/04
Filed: 1998-10-14
Abstract: The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH<SUB>2</SUB>, NHR, H or halogen; D is chosen from OH, NH<SUB>2</SUB>, NHR, H, halogen or SCH<SUB>3</SUB>; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO<SUB>2</SUB>H or a corresponding salt form, CO<SUB>2</SUB>R, CN, CONH<SUB>2</SUB>, CONHR or CONR<SUB>2</SUB>; and G is chosen from NH<SUB>2</SUB>, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof. The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.
Patent PT-947558-E (PT)
Inventor: DORN KLAUS
IPC: C08L33/12
Filed: 1999-03-29
Abstract: Plastisol contains and acrylate polymer with molecular weight greater than 2 X 106> g/mole and plasticiser. Plastisol comprises: (i) polymers and/or copolymers, with molecular weight greater than 2 X 106> g/mole, of: (a) 20-100 wt.% methyl methacrylate, (b) 0-80 wt.% linear or branched 1-18 C alkyl (meth)acrylate, of formula (I), (c) 0-40 wt.% other monomer, and (d) 0-40 wt.% adhesion promoting monomer; (ii) 5-400 pts. wt. compatible plasticiser; and (iii) 9-700 pts. wt. inorganic filler. [Image] R1hydrogen or methyl R2linear or branched 1-18 C alkyl An independent claim is also included for the use of the acrylate (co)polymer(s) in the production of plastisols.
Patent PT-957070-E (PT)
Inventor: BOOT FRANK LYN
IPC: C04B20/10
Filed: 1999-04-14
Abstract: A gypsum product is disclosed formed of set gypsum plaster slurry and having an exposed gypsum surface in which the moisture resistance of the gypsum surface is enhanced by the inclusion in the qypsum of a hydrophobic silicone and at least one potassium salt together with fumed silica.
Patent PT-1060841-E (PT)
Title: Self-adjusting pliers
Inventor: OLLACARIZQUETA MANUEL AZKONA
IPC: B25B7/10
Filed: 1999-06-15
Abstract: The pliers comprise two branches joined by a rod (15) having a female collar (1) which pivots on a pin (A) and guides a male collar (2) which slides inside and pivots on the male branch by means of a pin (B). A spring (3) sets the collars and a second spring (5) unites one (1) of the collars with the female branch. The male branch (6) has a head (7) having an upper toothed jaw (10) and a window (8) with teeth (9). The female branch (11) with a large opening allowing the passage of the male head carries a lower toothed jaw (13) and a toothed lug (14) which pivots on a spindle (21).
Patent SG-25893-G (SG)
Title: Sulfurized compositions,and additive concentrates and lubricating oils containing same
IPC: C10M135/06
Filed: 1993-03-09
Abstract: Sulfurized mixtures which include (A) at least one partial fatty acid ester of a polyhydric alcohol, and (B) at least one member of the group consisting of (1) at least one fatty acid ester of a polyhydric alcohol, which fatty acid ester is different from the partial ester (A), (2) at least one fatty acid, (3) at least one olefin, and (4) at least one fatty acid ester of a monohydric alcohol. The sulfurized compositions are useful in preparing additive concentrates and lubricating compositions.
Patent SG-43893-G (SG)
Title: Process for the preparation of an aqueous solution of a heteropoly-saccharide
IPC: C09K8/90
Filed: 1993-04-14
Abstract: An aqueous solution of a heteropolysaccharide comprising glucose, galactose, pyruvic and succinic acid, is prepared by mixing a concentrate of said heteropolysaccharide with a saline aqueous medium containing from 12 to 30%w of at least one salt, and by shearing the mixture obtained.
Patent SG-48692-G (SG)
Title: Debossing and perforating a polymeric web
IPC: A61F13/15
Filed: 1992-04-29
Abstract: @ A continuous, multi-phase process for debossing and perforating a substantially continuous web of substantially planar polymeric film to coincide with the image of one or more forming structures, each having a patterned forming surface with a multiplicity of holes and an opposed surface. Each forming structure is open from the holes in the forming surface to its opposed surface. The web of film has an indefinite length, a first surface, a second surface and a thickness. The thickness comprises the distance between the first surface and the second surface. The process comprises at least two sequential.forming phases, one of which involves three-dimensional conformance of the web to the macroscopic profile of the forming structure and another of which involves aperturing of the web to coincide with fine-scale apertures in either the same or a separate forming structure. The order in which the phases are carried out will depend upon the properties desired in the resultant macroscopically expanded, three-dimensional, apertured polymeric web. Because the process is carried out in sequential phases, previously incompatible characteristics which could not be provided by prior art single-phase forming processes can now be achieved.
Patent SG-58693-G (SG)
Title: Method of forming shaped hydrogel articles including contact lenses
IPC: C08F220/28
Filed: 1993-05-04
Abstract: Shaped hydrogel articles such as soft contact lenses are prepared by (1) molding or casting a polymerization mixture comprising: (a) a monomer mixture comprising a major proportion of a hydrophilic (meth)acrylate ester such as 2-hydroxyethyl methacrylate, and a cross-linking monomer; and (b) a water-displaceable diluent, wherein said diluent has a viscosity of at least 100 MPa Sec at 30 DEG C, and wherein said diluent consists essentially of a boric acid ester of certain dihydric alcohols, said dihydric alcohols having Hansen polar ( delta p) and Hansen hydrogen bonding ( delta h) cohesion parameters falling within the area of a circle defined as having a center at delta h = 20.5,  delta p = 13, and a radius of 8.5, to produce a shaped gel of a copolymer of said monomers and said diluent, and (2) thereafter replacing said diluent with water.
Patent SG-118792-G (SG)
Title: Screw threaded inserts
IPC: F16B37/12
Filed: 1992-11-10
Abstract: A screw threaded insert to be installed in for example thermoplastic material by ultrasonic vibrations applied to the insert is double-ended and comprises a main helically (40) ribbed portion separated from a minor portion (12) formed with teeth or projections aligned with helical ribs, and a pilot portion (10). The pilot portion is to locate the insert in a preformed bore in the required orientation of insertion, the toothed portion displaces material in complementary grooves, so as to facilitate travel of the insert into the material and ensure good filling of the inter-rib spaces.
Patent IE-40669-L (IE)
Title: Recovering protein by admixture with a phosphate
IPC: A23J1/20
Filed: 1975-02-19
Abstract: A protein having improved solution clarity at acid pH, suitable for the protein enrichment of acidic beverages, is isolated by treating a protein-containing aqueous solution with a phosphate, as a result of which a protein-phosphate complex is formed, adjusting the pH of the solution to 6 to 8 by addition of a base, separating off the precipitate formed during this from the pretreated protein-containing aqueous solution and mixing the latter with a polyphosphate of medium chain length. The pH of the protein-phosphate-complex-containing solution formed in this is adjusted by acid to 4.5 to 2.0, as a result of which the protein-phosphate complex is precipitated out. This is separated off from the supernatant solution and dispersed in water having a final pH of 5.0 to 12.0. The resulting dispersion is then brought into contact with an anion exchanger resin and the protein-containing solution eluting is isolated.
[GB1493677A]
Patent IE-880498-L (IE)
Title: Macromolecular platinum antitumor compounds
IPC: A61K47/36
Filed: 1988-02-24
Abstract: Novel composition of platinum-containing macromolecules for targeting by tumor-selective agents, such as monoclonal antibodies, or for sustained or controlled release in the treatment of tumor cells.
Patent IE-44723-L (IE)
Title: Horse shoes
IPC: A01L5/00
Filed: 1977-03-16
Abstract: This device serves for shoeing a horse and consists of a strip (15) made of flexible material with an L-shaped cross-section and of a shoe (14) made of synthetic resin. The strip is preshaped in such a manner that it bears against the walls (11, 12) of the hoof (10) and against its sole both at the front and laterally. For shoeing, first the strip (15) is fastened on the hoof and then the shoe is fastened on the strip. Such a shoe does not damage the horn walls and even horses with clefts or with brittle horn can be shod easily and correctly even by someone who is not trained as a farrier. <IMAGE>
[GB1517113A]
Patent IE-790802-L (IE)
Title: Cytological assay
IPC: G01N27/416
Filed: 1979-08-08
Abstract: A bioassay method is based on the detection of changes in the membrane potential of individual cells. A cell suspension is incubated with a solution of a substance capable of affecting the physiology of at least a subpopulation of cells in the suspension. During or after the incubation, a measurement representative of the membrane potential of individual cells is made. The preferred method of measuring membrane potential involves incubating the cells with a membrane-permeant, fluorescent, ionic dye which becomes distributed on opposite sides of the cell membrane as a function of membrane potential, and then assaying intracellular dye concentration by photometric measurements in a flow cytometer. <??>In one embodiment the cells are modified prior to the photometric measurements; this modification may involve reaction with, for example, hormones, pharmacological agents and proteins. <??>One application of the invention is in the evaluation of drugs. 
[EP0005032A2]
Patent IE-38031-L (IE)
Title: Biphenylylpropionic acid derivatives
IPC: C07C57/38
Filed: 1973-05-31
Abstract: New compounds are described that are 2-(hydroxy substituted-4-biphenylyl)propionic acids. Processes of making and using them and pharmaceutical compositions containing them are also described. The compounds have, inter alia, antiinflammatory activity.
[US3969402A]
Patent FI-822791-L (FI)
Inventor: SCHUPPISER JEAN-LUC
IPC: C08F218/08
Filed: 1982-08-10
Abstract: Latices of particles of vinyl acetate/olefin copolymers. The particles have an average diameter between 0.05 and 1  mu M. The copolymers have a glass transition temperature between -30 DEG  and 50 DEG  C. The particles are present in the latices in a concentration between 10 and 70% by weight. The latices contain a protective colloid comprising a water-soluble polymer (a) containing at least one monomer selected from the group consisting of N-methylolacrylamide and N-methylolmethacrylamide and a water-soluble polymer (b) of ethylene glycol, wherein polymer (b) has a molecular weight of between 1,000 and 50,000. The latices are prepared by polymerization in aqueous emulsion, in the presence of an initiator and the above-described protective colloid. The latices may be applied as binders in the manufacture of paints, glues, paper, textiles, floor coverings and mortar additives.
Patent FI-831645-L (FI)
Inventor: KORPMAN RALF
IPC: A61L15/00
Filed: 1983-05-11
Abstract: The invention provides an absorbent panel which consists of a paper, film or fabric substrate coated on at least one surface with a reactive composition containing from 10 to 40 parts by weight of a liquid polyhydroxy organic compound and from 90 to 60 parts by weight of a particulate water-insoluble, water-swellable absorbent polymer having a gel capacity of at least 10. The absorbent panel is capable of absorbing at least 15 times its weight of liquid and is a thin structure.
Patent IE-861057-L (IE)
Title: Preparation of midalcipran
IPC: C07C231/08
Filed: 1986-04-21
Abstract: 1. Process for the industrial preparation of (Z)-1-phenyl-1-diethylaminocarbonyl-2- aminomethylcyclopropane of formula I : see diagramm : EP0200638,P7,F2 characterized by the use of the following successive reaction steps : i) 1-phenyl-2-oxo-3-oxa(3: 1: 0) bicyclohexane of formula II : see diagramm : EP0200638,P8,F1 is opened by treatment with a phthalimide salt in an organic solvent ; ii) (Z)-1-phenyl-2-phthalimidomethylcyclopropane-carboxylic acid of formula III thus obtained see diagramm : EP0200638,P8,F2 is treated with an acid chloride, and then the acid chloride thus formed is amidified by condensation with diethylamine in an organic solvent ; and iii) (Z)-1-phenyl-1-diethylaminocarbonyl-2- phthalimidomethylcyclopropane of formula IV thus obtained : see diagramm : EP0200638,P8,F3 is then treated with an alkylamine or a primary hydroxyalkylamine by itself or in the presence of a solvent to obtain, after hydrochlorination, the compound of abovementioned formula I.
[EP0200638A1]
Patent IE-36737-L (IE)
Title: Preparing chlorine
IPC: C01B7/05
Filed: 1972-10-04
Abstract: 1405952 Chlorine RHONE-PROGIL 3 Oct 1972 [4 Oct 1971] 45489/72 Heading C1A Chlorine is prepared from a gaseous phase containing HCl by reacting the gas with a solid mixture comprising sodium chloride and iron oxide, the composition of the solid mixture being such that in the solid product obtained when equilibrium between the solid and gas phases is reached, the ratio of quantity of chlorine combined with iron to the quantity of chlorine combined with sodium is not higher than 1, and then reacting this solid product with an oxidizing agent to liberate chlorine. Preferably the ratio is not greater than 0À5. After reaction with the oxidizing agent, the ratio drops to from 0À01 to 0À1. The HCl gas phase may be reacted with the solid phase at 400 to 500 C., and the solid phase with the oxidizing agent at 450 to 600 C. The preferred oxidizing agent is oxygen. Before being contact with the HCl phase, the solid may be reacted with a reducing agent, e.g. a reducing gas. The solid mixture may contain an inert component, e.g. Al 2 O 3 or SiO 2 . The solid mixture may contain Cu or a rare earth metal, and, may be treated as a fluidized bed, and may have a specified particle size. The gaseous HCl phase may be produced by the sublimation of ammonium chloride.
[GB1405952A]
Patent IE-43248-L (IE)
Title: Araliphatic dihalogen compounds.
IPC: A61K31/22
Filed: 1976-06-25
Abstract: Compounds of the formula <IMAGE> wherein R1 and R2 are the same or different and are F, Cl or Br; Q is -CH(CH3)-CH2-, -C(OH) (CH3)-CH2- or -C(CH3) =CH-; Y is COOH, COOR3, CH2OH or CH2OAc; N IS 0 OR 1; R3 is alkyl or aryl of up to 8 carbon atoms or C6H4NHCOCH3; and Ac is acyl of 1-8 carbon atoms; AND PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF, ARE ANTI-INFLAMMATORY AGENTS, WHICH CAN BE MADE FROM COMPOUNDS OF THE FORMULA Z - X, wherein Z is <IMAGE> AND X can be converted to -Q-Y.
[US4057647A]
Patent IE-781513-L (IE)
Title: Extruding high-strength aluminium alloys.
IPC: C10N50/08
Filed: 1978-07-26
Abstract: 1. A method of extrusion, followed by quenching, of high-strength based aluminium alloys of series 2 000 and 7 000, wherein the extrusion ratio is from 20 to 200, characterised in that : a) extrusion is effected with a lubricant, at a speed of over 15 m/minute ; b) the extrusion temperature is between Ts -50 degrees C and Tm -180 degrees C, Ts being the equilibrium solidus temperature of the alloy, and is adjusted within that range so that the temperature of the metal leaving the die is between Tm and Ts , Tm being the minimum temperature at which the said alloy is solution heat treated ; c) the metal is quenched from extrusion heat at the usual cooling speeds for the alloy in question.
[EP0000684A1]