baber/WOPTO huggingface dataset:
Patent CA-3022097-A1 (CA)
Title: Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
Inventor: BELL LEONARD
IPC: A61K39/395
Filed: 2007-03-15
Abstract: Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (PNH). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center global Phase III trial. It has been found that eculizumab stabilized hemoglobin levels, decreased the need for transfusions, and improved quality of life in PNH  patients via reduced intravascular hemolysis. Chronic eculizumab treatment appears to be a safe and effective therapy for PNH.
Patent CA-3022887-A1 (CA)
Inventor: WOODALL PETER
IPC: C02F1/20
Filed: 2017-05-22
Abstract: A method for removing gas from a froth comprising the steps of supplying at least a portion of the froth from a vessel into a housing, providing a flow of fluid through the housing, introducing the froth into the fluid such that at least a portion of the gas in the froth is removed from the froth and entrained in the fluid to form a mixture of fluid and entrained gas and subsequently delivering the mixture to the vessel and/or another location within a processing circuit.
Patent CA-3025343-A1 (CA)
Title: Construction and characterization of multimeric il-15-based molecules with cd3 binding domains
Inventor: LIU BAI
IPC: C07K16/18
Filed: 2017-05-26
Abstract: The invention features soluble fusion protein complexes comprising at least two soluble fusion proteins. For example, the first fusion protein is an anti-CD3 antibody covalently linked to an interleukin-15 (IL-15) polypeptide or functional fragment thereof. The second fusion protein comprises a binding domain that recognizes disease antigens, wherein this domain is covalently linked to a soluble interleukin-15 receptor alpha (IL-15Ra) polypeptide or a functional fragment thereof. One or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof, and the IL-15 domain of first fusion protein binds to the soluble IL-15Ra domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
Patent CA-3025784-A1 (CA)
Title: Identification de dispositifs avec modulation transpositionnelle
Inventor: GERDES RICHARD C
IPC: H04L27/32
Filed: 2017-04-19
Abstract: La présente invention concerne des procédés, des systèmes et un appareil, incluant des programmes d'ordinateur codés sur un support de stockage d'ordinateur, pour la transmission, par un premier dispositif, d'un signal de transmission qui inclut un signal de porteuse modulé avec un signal de transmission. La réception d'un signal de réponse en provenance d'un second dispositif en réponse au signal de transmission. Le fait de déterminer si le signal de réponse inclut le signal de transmission.
Patent CA-3025994-A1 (CA)
Inventor: FOLKVANG JORN
IPC: B01D17/02
Filed: 2017-02-16
Abstract: An apparatus (100) for separating hydrocarbons from water including a tank segment (110), comprising a fluid inlet pipe (111) through a cylindrical tank wall (101), subsequent a gas mixer (109), the fluid inlet pipe (111) sub-sequently entering a truncated conical shaped tank segment (113) located inside the tank segment (110). The truncated conical shaped tank segment (113) comprising a pipe spread (114), securing tangentially distribution of the fluid along the inner wall of the conical tank segment (113) towards the upper part of the conical tank segment (113), wherein ring mounted spaced guide vanes (1140) are arranged at the upper part of the conical tank segment (113).
Patent CA-3027030-A1 (CA)
Inventor: CARDIN JULIE A
IPC: B65D75/30
Filed: 2017-06-08
Abstract: Embodiments include a package (100) for containing and dispensing a product (112). The package includes first and second layers (202, 204); a product seal zone (106) where the first layer is joined to the second layer, the product seal zone having an inner perimeter (108) that defines an unsealed pouch area (110) for containing the product and an outer perimeter (136); and a header zone (118) adjacent to the outer perimeter of the product seal zone. The header zone includes a first tab (122); a second tab (124); a first tab-cut (126) in the first layer (202) within an unsealed portion of the header zone; and a second tab-cut (128) in the second layer (204) within the unsealed portion of the header zone.
Patent CA-3034771-A1 (CA)
Inventor: NGUYEN ANDREW
IPC: G16B5/00
Filed: 2017-08-25
Abstract: Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.
Patent CA-3037787-A1 (CA)
Title: Rubber tips for handheld locking pliers
IPC: B25B7/00
Filed: 2019-03-25
Abstract: This invention is a rubber device that slips on and off the tooth sided face of already existing rigid or steel handheld locking pliers. Each device comes in a set of two identical pieces that are used together, one for each side of the pliers.  They are made from a soft polyurethane compound which establishes a soft and protective layer between the tool and the object. This increased protection prevents any damage to both the object being worked on as well as the tool itself. It also allows for a more accurate & solid grip then any traditional handheld locking pliers available. The physical size varies from apparatus to apparatus as it is compatible with and complies to various sizes and styles of handheld locking pliers.
Patent CA-3037991-A1 (CA)
Inventor: DI UBALDI JOHN
IPC: A61J15/00
Filed: 2017-10-04
Abstract: A syringe having barrel and a non-luer tip that is not connectable to an intravenous device is disclosed. The syringe as an enteral collar engagement feature adjacent the distal end of the syringe barrel. The syringe has an enteral collar having a distal end and proximal end, the proximal end having a syringe engagement feature complementary to and engagable with the enteral collar engagement feature. The enteral collar is sized to permit connection to an enteral device and prevent connection to a device having a luer connector.
Patent CA-3040456-A1 (CA)
Inventor: DAVIS JASON
IPC: H01L35/30
Filed: 2017-10-12
Abstract: A flexible heat sink with a flexible base having a first side configured to engage a heat generating component, and a second side opposite the first side. A plurality of fins extends from the second side of the base and each fin is made from a flexible graphite ribbon assembly. The plurality of fins may be a row of fins made from a single graphite ribbon assembly. Each fin may be configured with a u-shaped or triangular shaped channel. A flexible heat sink assembly may be configured with multiple flexible heat sinks sharing one common base. The heat sinks and rows of fins may be spaced apart in the heat sink assembly to create an array of fins enabling the heat sink assembly to flex lengthwise and widthwise across the base.
Patent CA-3040484-A1 (CA)
Title: Fluid injector with syringe engagement mechanism
Inventor: COWAN KEVIN
IPC: A61M5/315
Filed: 2017-10-16
Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and radially movable relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are engaged with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.
Patent CA-3040782-A1 (CA)
Title: Wireless communication of information from access control device to mobile communications device
Inventor: HU JONATHAN
IPC: H04W4/02
Filed: 2017-10-30
Abstract: Wireless communication of information from an access control device to a mobile communications device is disclosed. A mobile communications device generates, on a display, a user interface page that provides a rendering of a floor map, the floor map including a plurality of access controlled doors icons in arranged graphical display so as to correspond to known locations of actual access controlled doors that the access controlled doors icons represent. The mobile communications device receives a plurality of wireless signals. The mobile communications device processes the wireless signals to obtain or derive information to enable calculation of a location of the mobile communications device relative to at least some of the known locations of the actual access controlled doors. The floor map includes a person icon positioned therein such that the calculated location is visually conveyed to a user of the mobile communications device.
Patent CA-3041817-A1 (CA)
Title: Appareil de nettoyage
Inventor: TWEEDIE ROBERT
IPC: A61C17/02
Filed: 2017-10-17
Abstract: Un système de distribution de fluide pour un appareil de nettoyage dentaire comprend une buse pour distribuer une rafale de fluide de travail aux dents d'un utilisateur, et un conduit de fluide pour transporter un fluide de travail vers la buse. Un corps de la buse définit une chambre de fluide et un canal pour transporter le fluide de travail de la chambre de fluide à une sortie de fluide de la buse. La chambre de fluide a une entrée tangentielle pour recevoir un fluide de travail provenant du conduit de fluide.
Patent CA-3042723-A1 (CA)
Title: Quantitative cluster analysis method of target protein by using next-generation sequencing and use thereof
Inventor: KIM SUNG CHUN
IPC: C12Q1/68
Filed: 2017-11-02
Abstract: Disclosed is a quantitative cluster analysis method of target proteins by using next-generation sequencing. The method of the present invention comprises the steps of: (a) treating a sample to be analyzed with a library of aptamers which directs toward a group of target proteins present in the sample so as to form complexes between target proteins and aptamers binding specifically thereto, with the consequent formation of a complex cluster of the target proteins and aptamers; (b) separating the complex cluster from unbound aptamers; and (c) analyzing a sequence of each of the aptamers in the complex cluster by a next-generation sequencing analysis technique so as to quantify each of the aptamers in the complex cluster and thereby to quantify each of target proteins in the complex cluster. The method of the present invention can be very useful in collectively quantifying proteins in an analysis sample.
Patent CA-3043037-A1 (CA)
Title: Complete volume draining oil pan and device
Inventor: BLUNDY GEORGE
IPC: F16N31/00
Filed: 2017-11-17
Abstract: A drain tube device that includes a first tubular region, a second region and arcuate tubular region interposed between the first tubular region and the second region. In certain embodiments, the arcuate region is contiguously joined to the first tubular and the second region such that the first tubular region and the second region form an acute angle in a first plane that is between 45° and 90°. The second region has an end distal to the arcuate tubular region and includes a longitudinal opening defined in at least a portion of the region between the arcuate tubular region and the distal end. In certain embodiments, the arcuate region can also have a configuration that provides an angle located out of the first plane between the first tubular region and the second region that is between zero and 90°.
Patent CA-3043866-A1 (CA)
Title: Selecting products in a virtual environment
Inventor: WILKINSON BRUCE W
IPC: G06Q50/28
Filed: 2017-10-12
Abstract: In some embodiments, apparatuses, and methods are provided herein useful to selecting products for customers. In some embodiments, a system comprises a value vector database, wherein the value vector database includes value vectors of customers, and wherein the value vectors indicate partialities of the customers, a control circuit configured to generate the virtual representation of the customer's environment, determine, based on the value vector database, partialities for the customer, determine, based on the partialities for the customer, one or more products, wherein the one or more products include value propositions, and wherein the one or more value propositions of the one or more products are consistent with the partialities for the customer, and render the virtual representation of the customer's environment to include virtual representations of the one or more products, and a display device, the display device configured to present the virtual representation of the customer's environment.
Patent CA-3045396-A1 (CA)
Inventor: ANDERSEN HAROLD W
IPC: A01N3/00
Filed: 2019-06-06
Abstract: Il est décrit des appareils et méthodes servant à décontaminer du matériau agricole, lequel matériau peut comprendre des acides carboxyliques. Les méthodes en question consistent à mettre le matériau agricole en contact avec un montant suffisant doxyde d'éthylène à une température entre 15 ºC et 30 ºC environ pendant un intervalle suffisant pour désinfecter les produits. La stérilisation à loxyde déthylène réalisée à ces températures suffit pour éliminer toute contamination microbienne, mais ne peut pas faire en sorte quune quantité suffisante de groupes dacides carboxyliques réagisse avec loxyde déthylène pour produire des esters. Des appareils servant dexemple comprennent des sacs de stérilisation rangés facultativement dans des armoires de stérilisation, des bidons étanches et des chambres de désinfection installées sur des palettes, lesquels appareils sont tous adaptés pour purger loxyde déthylène du matériau agricole de manière sécuritaire par suite de la stérilisation. Des matériaux agricoles servant dexemple comprennent notamment du chanvre et de la marijuana.
Patent CA-3049512-A1 (CA)
Title: Method and device for generating a 3d model of a bearing structure of an escalator or a moving walkway
Inventor: EDER CHRISTOPH
IPC: B66B23/00
Filed: 2018-02-20
Abstract: The invention describes a method and a device (41) that can be used in particular during modernisation measures to measure structural components (26) of a supporting structure (2) of an escalator (1) or moving walkway without specialists having to take precise measurements locally. The method comprises the following steps: fixing an image capture device (43), such as a 3D scanner or TOF camera, to a conveying device (13) of the escalator (1); removing at least one of the step units (7) of the escalator (1) to provide visual access (49) to the underlying structural components (26) to be measured; circumferentially displacing the conveying device (13) together with the image capture device (43) attached thereto at least over portions of a movement path (5); capturing images of the structural components (26) to be measured using the image capture device (43) at a plurality of positions along the movement path (5); and generating a 3D model at least of portions of the structural components (26) of the supporting structure (2) on the basis of the captured images. On the basis of the 3D models, specialists can then take measurements and measure the spatial arrangements of the structural components (26) without having to be present locally.
Patent CA-3050215-A1 (CA)
Inventor: GARNER ELIJAH
IPC: A01C7/16
Filed: 2012-03-23
Abstract: A planting unit for a seeding machine is disclosed having a frame member and a seed meter mounted thereto. The seed meter has a housing and a metering member rotatably mounted therein. The metering member has a sidewall with an inner surface and an outer surface and a rim portion adjacent an outer edge of the sidewall. The inner surface of the side wall and the housing form a trough at a bottom portion of the metering member to hold a seed pool. A  mechanical seed delivery system takes seed from the metering member and moves seed to a discharge location adjacent a seed furrow formed in soil beneath the seeding machine.
Patent CA-3050389-A1 (CA)
Inventor: JOHNSON SCOT ARTHUR
IPC: G06F1/26
Filed: 2019-07-22
Abstract: Several transportable datacenters are described. The transportable datacenters include transport systems allowing them to be transported between an assembly location and an operating location. The transportable datacenters also include a ventilation system for cooling processors positioned in racks in the datacenters. The ventilation system draws cold air from the environment, through processor bays containing the processors and then exhausts the air back to the environment.
Patent CA-3053920-A1 (CA)
Title: Support stand for magnetic resonance imaging scanner
Inventor: MORREALE MARK TULLIO
IPC: G01R33/48
Filed: 2019-09-04
Abstract: A support stand for supporting a magnetic resonance imaging (MRI) scanner while in operation. A MRI scanner includes a cylindrical housing having a lateral surface extending parallel to a horizontal patient bore to encapsulate a main cylindrical magnet. The cylindrical housing defines a longitudinal footprint dimension and a lateral footprint dimension. The support stand includes a base and a plurality of pillars extending upright from the base. Each respective pillar includes a first end mounted to the base and an opposing second end. The support stand also includes a vibration isolator mounted at the second end of the respective pillars to support the lateral surface of the cylindrical housing. The respective vibration isolators minimize transmission of environment borne vibrations to the MRI  scanner or minimize transmission of MRI scanner generated vibrations to the environment.
Patent CA-3055271-A1 (CA)
Title: Compositions et methodes pour le traitement de maladies inflammatoires
Inventor: KOLTAI HINANIT
IPC: A61P1/00
Filed: 2018-03-05
Abstract: La présente invention a trait à une méthode de traitement d'une maladie inflammatoire chez un sujet qui en a besoin. La méthode comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une fraction de chromatographie liquide d'un extrait de cannabis comprenant au moins 75 % d'acide tétrahydrocannabinolique (THCA), la fraction comprenant des ingrédients actifs dérivés du cannabis autres que le THCA.
Patent CA-3055500-A1 (CA)
Inventor: RIZVI BUTURAB
IPC: H04W92/02
Filed: 2019-09-16
Abstract: A POS device receives a first authorization value from an input device, and receives from a mobile device, via a LAN interface, a user identifier and a data structure that includes an adjustment value and a structure identifier. The POS device transmits the data structure and the user identifier to a validation server, via a WAN interface. The POS device receives from the validation server, via the WAN interface, confirmation that the validation server had previously saved the structure identifier of the data structure in a database in association with the user identifier. The POS device recovers the adjustment value from the data structure, generates a second authorization value from a difference between the first authorization value and the adjustment value, and transmits an authorization request message over a payment network via the WAN interface. The authorization request message includes the second authorization value.
Patent CA-3057023-A1 (CA)
Inventor: COLISTRO VINCENT
IPC: B60D1/46
Filed: 2019-09-27
Abstract: An implement includes a hydraulic control to move rear wheels upward and downward. A hitch frame has a rear end pivotally connected to a front of the implement's frame about an upper hitch pivot axis and a front end connectable to a tractor drawbar. A tension link has a rear end pivotally connected to the front end of the implement about a lower hitch pivot axis located below and parallel to the upper hitch pivot, and a front end movably mounted to a front of the hitch frame. A front hydraulic cylinder moves the front end of the tension link forward and rearward. The hydraulic control activates the front hydraulic cylinder to move the tension link rearward as the rear hydraulic cylinder moves the rear wheels upward with respect to the implement frame, and to move the front end of the tension link forward as the rear wheels move downward.
Patent CA-3057155-A1 (CA)
Inventor: MERRIMAN BARRY L
IPC: C12Q1/6813
Filed: 2018-04-25
Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.
Patent CA-3057198-A1 (CA)
Inventor: LATULIPE ERIC
IPC: H02K16/02
Filed: 2019-10-01
Abstract: An electric machine system described herein comprises a first and second electric machines configured to drive a load. The first electric machine has a plurality of first rotors driven using electric power having a first phase. The second electric machine has a plurality of second rotors driven using electric power having a second phase. The second phase differs from the first phase. Each of one or more shafts connects a first rotor with a second rotor. The first rotor is coaxial with and axially spaced apart from the second rotor.
Patent CA-3057429-A1 (CA)
Title: Oral care compositions comprising hemp seed oil and caprylyl glycol
Inventor: ANSARI SHAMIM
IPC: A61K8/92
Filed: 2017-05-17
Abstract: Disclosed herein are oral care compositions comprising hemp seed oil and caprylyl glycol. In certain embodiments, the oral care composition optionally further comprises one or more ingredients selected from hyaluronic acid and aloe vera. Methods of making and using the compositions are also provided.