baber/WOPTO huggingface dataset:
Patent WO-2018218042-A1 (WO)
Inventor: WANG GUOQIANG
IPC: A61K31/42
Filed: 2018-05-24
Abstract: La présente invention concerne des composés de formule (I), ou des sels pharmaceutiquement acceptables, un ester, un stéréoisomère, un tautomère, un solvate, un hydrate ou une combinaison de ceux-ci : qui inhibent la kinase de régulation de signal d'apoptose 1 (ASK-1), qui est associée à des troubles auto-immuns, des troubles neurodégénératifs, des maladies inflammatoires, une maladie rénale chronique, une maladie cardiovasculaire. La présente invention concerne en outre des compositions pharmaceutiques comportant les composés mentionnés ci-dessus pour administration à un sujet souffrant d'une maladie liée à ASK-1. L'invention concerne en outre des procédés de traitement d'une maladie liée à ASK-1 chez un sujet par administration d'une composition pharmaceutique comprenant les composés selon la présente invention. La présente invention concerne spécifiquement des procédés de traitement de la stéatose hépatique liée à ASK-1, comprenant la stéatose hépatique non alcoolique (NAFLD) et la stéatohépatite non alcoolique (NASH).
Patent WO-2018222637-A1 (WO)
Title: Lampe électrique comportant un couvercle à guide de lumière
Inventor: ALISAFAEE HOSSEIN
IPC: F21K9/61
Filed: 2018-05-30
Abstract: L'invention concerne une lampe électrique (1). La lampe (1) comporte une base (200), un élément électroluminescent (401) et un couvercle (301) recouvrant la source de lumière. Un guide de lumière (350) transporte la lumière de la source de lumière à une surface réfléchissante située dans le couvercle (301). Des rayons lumineux suivent un parcours transversal à travers le couvercle (301).
Patent WO-2018232341-A1 (WO)
Title: Connecteur de charge
Inventor: KRUSZELNICKI MARTIN
IPC: B60L11/18
Filed: 2018-06-15
Abstract: L'invention concerne un système de station de charge pour charger un véhicule électrique qui comprend une station de charge pourvue d'un dispositif de commande conçu pour commander la charge d'un véhicule électrique, et un connecteur de charge dans le sol pouvant être déplacé entre des configurations rangée et déployée. La station de charge est conçue pour être connectée à un réseau électrique moyenne tension (MV), et le dispositif de commande est conçu pour charger une batterie d'un véhicule électrique en prise fonctionnelle avec la station de charge. Le connecteur de charge dans le sol comprend au moins une borne de charge mobile verticalement entre des positions rangée et déployée. Ladite au moins une borne de charge est conçue pour venir fonctionnellement en prise avec le véhicule électrique dans la position déployée afin de charger une batterie du véhicule électrique, et est généralement disposée sous la surface du sol sur laquelle repose le véhicule électrique lorsqu'elle est en position rangée.
Patent WO-2019006030-A1 (WO)
Title: Methods and arrangements to support compatible low rate for wake-up radio packet transmission
Inventor: AZIZI SHAHRNAZ
IPC: H04L27/02
Filed: 2018-06-27
Abstract: Logic may define two or three or more of different packet formats for a WUR packet. Logic may define a WUR packet format for, e.g., a 1x symbol duration for compatibility with 802.11 main radios. Logic may generate a wake-up radio packet, wherein the wake-up radio packet comprises an on-off keying (OOK) signal, wherein a rate of transmission of one or more OOK symbols of the wake-up radio packet is set to a rate of transmission of one or more orthogonal frequency-division multiplexing (OFDM) symbols. Logic may apply Manchester coding to the wake-up radio packet transmissions. And logic couple with a physical layer device to generate OOK symbols for a transmission rates of, e.g., 250 kilobits per second and/or 62.5 kilobits per second.
Patent WO-2019028051-A1 (WO)
Title: Compositions and methods for treating cancer with anti-cd19/cd20 immunotherapy
Inventor: ORENTAS RIMAS J
IPC: A61P35/00
Filed: 2018-07-31
Abstract: Chimeric antigen receptors containing CD19/CD20 or CD20/CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
Patent WO-2019028346-A1 (WO)
Title: Handheld punch tool
Inventor: STREET WILLIAM
IPC: B23D27/04
Filed: 2018-08-03
Abstract: A handheld punch tool includes a housing defining a first axis, a motor contained within the housing, the motor having a motor shaft defining a second axis, and a head coupled to the housing and rotatable relative to the housing about a third axis. The head includes a drive member reciprocable along the third axis in response to rotation of the motor shaft about the second axis and a punch coupled to the drive member and reciprocable along a fourth axis in response to reciprocation of the drive member along the third axis. The third axis is perpendicular to the first axis, and the fourth axis is parallel to the third axis such that rotation of the head about the third axis varies a position of the punch relative to the housing.
Patent WO-2019036374-A1 (WO)
Title: 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
Inventor: HEIN CHRISTOPHER
IPC: A61P29/00
Filed: 2018-08-13
Abstract: Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula (I). The compounds are useful for treating inflammatory and autoimmune diseases.
Patent WO-2019036658-A1 (WO)
Title: Compositions comprising non-halogenated solvents for use in oil and/or gas wells and related methods
Inventor: SMITH RICHARD
IPC: C09K8/60
Filed: 2018-08-17
Abstract: Compositions comprising non-halogenated solvents for use in various aspects of a life cycle of an oil and/or gas well, and related methods, are provided. In some embodiments, the composition comprises a solvent blend and one or more surfactants. In some embodiments, the solvent blend comprises a first type of solvent (e.g., a terpene) and a second type of solvent (e.g., a non-halogenated solvent). The composition may comprise about 90 wt% to 99.9 wt% of the solvent blend, and about 0.1 wt% to 10 wt% of one or more surfactants, versus the total weight of the composition. In some embodiments, compositions can be used in methods for treating an oil and/or gas well, having a wellbore that comprises one or more fluids. A composition may be delivered into the wellbore, passing through the one or more fluids to reduce residues comprising asphaltenes, paraffins or combinations thereof on or near the wellbore.
Patent WO-2020023066-A1 (WO)
Title: Intelligent serendipitous document discovery notifications
Inventor: DORNBUSH SANDOR
IPC: G06Q50/00
Filed: 2018-08-21
Abstract: A method of notifying a document to a user of a cloud-based content management platform including identifying a first set of documents, wherein the first set of documents is hosted by the cloud-based content management platform and does not include one or more documents recently opened by the user, identifying one or more target documents from the first set of documents for the user based on an amount of overlap in topicality between a respective document and a users current working set of documents, a number of view events of the respective document, and a number of collaborative events associated with the respective document, wherein the users current working set of documents comprises documents the user has accessed within a last predetermined time period via the cloud-based content management platform, providing a graphical user interface (GUI) of a cloud storage of the user hosted by the cloud-based content management platform for presentation to the user, the GUI identifying the one or more target documents.
Patent WO-2020046281-A1 (WO)
Inventor: COLES RANDOLPH SCOTT
IPC: E21B33/134
Filed: 2018-08-28
Abstract: A tool brake is provided for use in horizontal wells that is positionable between a setting tool and a setting sleeve in combination with a tool string. Upon activation of the setting tool to set a bridge plug in a well, the normal action of the setting tool causes activation of the tool brake that extends one or more arms from the tool brake to exert pressure against the wellbore casing of the well. The tool brake prevents reverse slippage caused by gravity's pull of the tool string in a horizontal well permitting accurate placement of downhole tools such as perforating guns. Moreover, inadvertent cutting of a cable that retrieves the downhole tools can be prevented such as due to slippage of downhole tools over-lapping the cable before perforating guns are detonated.
Patent WO-2019055609-A1 (WO)
Title: Biomarkers and methods for assessing myocardial infarction and serious infection risk in rheumatoid arthritis patients
Inventor: CURTIS JEFF
IPC: G01N33/53
Filed: 2018-09-13
Abstract: Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
Patent WO-2019055614-A1 (WO)
Title: Systems and methods for dynamic delivery
Inventor: NATARAJAN BALASUBRAMANIAN
IPC: H04W24/00
Filed: 2018-09-13
Abstract: Systems, methods, and machine readable media are provided for dynamic delivery scheduling. In exemplary embodiments, order data and travel data is received. The travel data includes a travel service identifier related to a travel facility, an expected arrival time at the travel facility, and an identification of a destination facility. An order request is transmitted with the order data to the destination facility. The destination facility includes a geo-fence configured to detect an individual's mobile device, and the order request is processed by the destination facility upon detection of the individual's mobile device via the geo-fence. Following an updated arrival time being identified for the individual at the travel facility, a command may be transmitted to the destination facility to deliver the order to a location in the travel facility when the updated arrival time is forecasted to be outside of an operating hours' time period for the destination facility.
Patent WO-2019060769-A1 (WO)
Title: Constant-directivity two way wedge loudspeaker system
Inventor: SARVIS HUGH
IPC: H04R1/40
Filed: 2018-09-21
Abstract: A loudspeaker for use in a system of loud speakers comprises a wedge-shaped cabinet having front, back, top, bottom, left and right side faces, a baffle positioned and covering a portion of the front face of the cabinet, a low frequency driver positioned behind the baffle and spaced rearwardly therefrom toward the back face of the cabinet, and a vertically-aligned array including a plurality of high frequency drivers supported by the baffle and shaped, sized and positioned to adjoin with common spacing to a further loudspeaker in the system of loudspeakers.
Patent WO-2019067459-A1 (WO)
Title: Systems and methods for venting enclosure
Inventor: FORD SCOTT ALLEN
IPC: H01L23/02
Filed: 2018-09-25
Abstract: The present disclosure relates to an enclosure (140) of a vapor compression system (14), where a component (142) is disposed within the enclosure (140). The component (142) is fluidly coupled to the vapor compression system (14) and configured to discharge a flow of fluid. The enclosure (140) includes a hole (182) within a portion (179) of the enclosure (140) and a relief valve (152) disposed within the hole (182) of the enclosure (140), where the relief valve (152) is configured to discharge the flow of fluid in a first direction (200) through a passage within the relief valve (152). The passage extends from an interior region (145) of the enclosure (140) to an environment (144) external of the enclosure (140). The relief valve (152) is configured to block a second flow of fluid through the passage in a second direction, where the second direction is opposite of the first direction (200).
Patent WO-2019067489-A1 (WO)
Title: Fall sensing and medical alert systems
Inventor: MOURADIAN VAHRAM
IPC: G08B21/04
Filed: 2018-09-26
Abstract: A fall detection device having a wearable housing, a processor, a sensor system operatively connected to the processor and configured to detect a physiological condition of the wearer's body, a motion sensor, a wireless communication module processor, and a memory. The memory stores computer readable instructions that cause the processor to : monitor the motion sensor to detect a decrease in acceleration in the gravitational direction below a first threshold; start a timer upon detecting the decrease in acceleration; monitor the motion sensor to detect a fall-indicative acceleration above a second level prior to the timer reaching a first predetermined time; monitor the motion sensor to detect a recovery-indicative acceleration above a third level prior to the timer reaching a second predetermined time; and activate the wireless communication module to initiate an emergency alert if the fall-indicative acceleration is detected and the recovery-indicative acceleration is not detected.
Patent WO-2019071034-A1 (WO)
Title: Magnetic field generation with magneto-caloric cooling
Inventor: CARVER DAVID
IPC: H02N11/00
Filed: 2018-10-04
Abstract: An apparatus can comprise a DC power supply to generate a DC electrical signal, a pulse generator to generate an electrical pulse, and an electrical element. The pulse generator and the DC power supply can be electrically coupled together. The electrical element can receive the DC electrical signal and the electrical pulse. The electrical element can generate a magnetic field in response to receiving the DC electrical signal and cool in response to receiving the electrical pulse.
Patent WO-2020086063-A1 (WO)
Title: Fluid handling assembly and related tube set and method for use in surgical procedures
Inventor: PAYNE TIMOTHY
IPC: A61M1/00
Filed: 2018-10-23
Abstract: A fluid handling system for a surgical procedure includes a console and a tubing set. The console exhibits a peristaltic pump, a pinch valve, one above the other. Two recessed seats are located to the left and right sides of the pump and valve. The tubing set includes an irrigation tube and an aspiration tube each coupled to a pair of magnetic disks disposable in respective ones of the recessed seats. Upon such disposition, the irrigation tube is disposable in operative engagement with the peristaltic pump and the aspiration tube is insertable into a slot of the pinch valve.
Patent WO-2019089453-A1 (WO)
Title: Detection of noise signals in cardiac signals
Inventor: CHENG Ya-Jian
IPC: A61B5/00
Filed: 2018-10-29
Abstract: Medical device systems include processing circuitry configured to acquire sensed cardiac signals associated with cardiac activity of a heart of a patient, and to analyze the sensed cardiac signals to determine if a noise signal is present within the cardiac signals.
Patent WO-2019089613-A1 (WO)
Inventor: CHAND JESSE
IPC: G06T13/40
Filed: 2018-10-30
Abstract: La présente invention concerne un procédé destiné à générer et à afficher une interface de communication qui facilite le partage d'émotions par la création d'avatars 3D, et plus particulièrement avec la création de telles interfaces pour afficher des avatars 3D destinés à être utilisés avec des dispositifs mobiles, des systèmes à base de nuage et similaires.
Patent WO-2019126433-A1 (WO)
Title: Dispositif de collecte de tartre pour réacteurs à courant descendant
Inventor: XU ZHANPING
IPC: B01D24/22
Filed: 2018-12-20
Abstract: L'invention comprend un dispositif de collecte de tartre qui est situé à l'intérieur d'une tête de réacteur à courant descendant pour éliminer les solides des courants d'alimentation pour augmenter le temps de cycle de fonctionnement du réacteur sans impact sur l'espace de réacteur efficace pour le chargement du catalyseur. Plus particulièrement, une zone de filtrage est située dans une partie supérieure d'une cuve de réacteur au-dessus d'un plateau de distribution de liquide rugueux et d'un plateau de distribution.
Patent WO-2019126574-A1 (WO)
Inventor: OSTERTAG ERIC
IPC: A61K35/17
Filed: 2018-12-20
Abstract: Disclosed are VHH chimeric antigen receptors (VCARs), VCAR transposons encoding VCARs of the disclosure, cells modified to express VCARs of the disclosure, as well as methods of making and methods of using the same for adoptive cell therapy.
Patent WO-2019152733-A1 (WO)
Title: Methods of treating fibrotic pathologies
Inventor: TSCHUMPERLIN DANIEL J
IPC: A61K31/4188
Filed: 2019-01-31
Abstract: The present application provides methods for treating or preventing diseases and conditions associated with tissue fibrosis.
Patent WO-2019160821-A1 (WO)
Title: Compact portable/fixed airfield light
Inventor: SHEMWELL DAVID MARK
IPC: H05B39/00
Filed: 2019-02-11
Abstract: The invention relates to an airfield light comprising a body, a medium intensity lighting arrangement, and a high intensity lighting arrangement. The medium intensity lighting arrangement provides an omnidirectional light source, and the high intensity lighting arrangement provides a unidirectional or bidirectional light source. The invention is energy efficient compared to conventional airfield lights, and has particular application to temporary airfields. LEDs may be used as the light sources.
Patent WO-2019178573-A1 (WO)
Title: Truncated cartilage-homing peptides and peptide complexes and methods of use thereof
Inventor: NAIRN NATALIE WINBLADE
IPC: C07K19/00
Filed: 2019-03-15
Abstract: Truncated, variant, or mutated peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for truncated or mutated peptides or truncated or mutated peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver truncated or mutated peptide or truncated, variant, or mutated peptides or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.
Patent WO-2019195774-A1 (WO)
Title: Shader binding management in ray tracing
Inventor: STICH MARTIN
IPC: G06T15/06
Filed: 2019-04-05
Abstract: In various examples, shader bindings may be recorded in a shader binding table that includes shader records. Geometry of a 3D scene may be instantiated using object instances, and each may be associated with a respective set of the shader records using a location identifier of the set of shader records in memory. The set of shader records may represent shader bindings for an object instance under various predefined conditions. One or more of these predefined conditions may be implicit in the way the shader records are arranged in memory (e.g., indexed by ray type, by sub-geometry, etc.). For example, a section selector value (e.g., a section index) may be computed to locate and select a shader record based at least in part on a result of a ray tracing query (e.g., what sub-geometry was hit, what ray type was traced, etc.).
Patent WO-2019209678-A1 (WO)
Title: Access to dram through a reuse of pins
Inventor: MATULIK ERIC
IPC: G06F13/42
Filed: 2019-04-22
Abstract: An apparatus includes an interface for dynamic random access memory (DRAM); and an integrated circuit. The integrated circuit includes a memory pinout configured to connect to the memory and control logic. The control logic is configured multiplex address information, command information, and data to be written to or read from the DRAM memory on a subset of pins of the memory pinout to the DRAM memory. The control logic is further configured to route other signals on other pins of the memory pinout to the DRAM in parallel with the multiplexed address information, command information, and data information.
Patent WO-2019210013-A1 (WO)
Title: Kinetic automobile
Inventor: DERISSAINT ROGER
IPC: B60W20/14
Filed: 2019-04-24
Abstract: The "Kinetic Kar" will have a large high pressure chamber filled with hydraulic fluid pressured up to 20 ton for the initial motion of the car. The pressure harvested by means of pumps, pistons, valves, and electrical gadget will be too high for the high pressure chamber. It is estimated that the car will move from zero to 20 miles in a matter of 2 seconds and run at up to 150 miles per hour for a mile before pressure tank is depleted totally. It will only take 3-4 seconds for pressure reservoir to replenish.
Patent WO-2019213545-A1 (WO)
Inventor: PANDEY ANJALI
IPC: C07D239/47
Filed: 2019-05-03
Abstract: La présente invention concerne des procédés de préparation de cerdulatinib de formule (I) : formule (I) ou un sel de celui-ci. L'invention concerne également des intermédiaires et des procédés pour la préparation des intermédiaires utiles dans la préparation de cerdulatinib ou d'un sel de celui-ci.
Patent WO-2019221957-A1 (WO)
Inventor: DWARI SUMAN
IPC: G01S7/40
Filed: 2019-05-06
Abstract: Un scanner d'un système de détection optique comprend un boîtier, une surface optique couplée au boîtier, et un actionneur couplé à la surface optique. La surface optique est mobile pour diriger la lumière dans une zone balayée et pour recevoir une impulsion de lumière réfléchie à partir de la zone balayée. L'actionneur peut être actionné pour agiter la surface optique pour éliminer les débris de la surface optique.
Patent WO-2019222328-A1 (WO)
Title: Compositions and methods for the treatment of parkinson's disease
Inventor: RAVINA BERNARD
IPC: A61K48/00
Filed: 2019-05-15
Abstract: The present disclosure relates to methods, formulations and devices for the delivery and therapeutic administration of polynucleotides encoding AADC. The present disclosure relates to methods, formulations and devices for the delivery and therapeutic administration of AAV vectors which include polynucleotides encoding AADC. The present disclosure relates to methods, formulations and devices for the delivery7 and therapeutic administration of polynucleotides encoding AADC in the treatment of neurological diseases, disorders and conditions, including Parkinson's Disease.
Patent WO-2020231440-A1 (WO)
Title: Dispositifs et procédés de neuromodulation
Inventor: ROMERO-ORTEGA MARIO I
IPC: A61N1/04
Filed: 2019-05-16
Abstract: L'invention concerne, selon un aspect, un dispositif de neuromodulation. Selon certains modes de réalisation, un dispositif de neuromodulation comprend une chambre utilisable pour recevoir un nerf, au moins une électrode disposée dans la chambre, et un canal défini par deux parois. Selon certains modes de réalisation, le canal du dispositif est en communication fluidique avec un intérieur de la chambre et une surface externe du dispositif. Selon un autre aspect, l'invention concerne des procédés de neuromodulation. Selon certains modes de réalisation, les procédés décrits ici peuvent utiliser un ou plusieurs dispositifs de neuromodulation décrits ici.