Patent SG-11201809276Q-A (SG)
Title: N-((heteroarylmethyl)-heteroaryl-carboxamide derivatives as plasma kallikrein inhibitors
Inventor: SMITH ALUN JOHN
IPC: C07D471/04
Filed: 2015-11-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/083816 Al 2 June 2016 (02.06.2016) WIPO I PCT (51) International Patent Classification: CO7D 401/14 (2006.01) CO7D 471/04 (2006.01) A61K 31/444 (2006.01) A61P 3/00 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) A61K 31/4725 (2006.01) A61P 27/00 (2006.01) A61K 31/506 (2006.01) (21) International Application Number: PCT/GB2015/053610 (22) International Filing Date: 26 November 2015 (26.11.2015) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1421088.4 27 November 2014 (27.11.2014) GB (71) Applicant: KALVISTA PHARMACEUTICALS LIM- ITED [GB/GB]; Building 227, Tetricus Science Park, Por- ton Down, Salisbury SP4 OJQ (GB). (72) Inventors: SMITH, Alun John; c/o Sygnature Discovery Ltd, BioCity, Pennyfoot Street, Nottingham NG1 1GF (GB). NOVAK, Andrew Richard; c/o Sygnature Discov- ery Ltd, BioCity, Pennyfoot Street, Nottingham NG1 1GF (GB). EVANS, David Michael; c/o Kalvista Pharmaceut- icals Limited, Building 227, Tetricus Science Park, Porton Down, Salisbury SP4 OJQ (GB). EDWARDS, Hannah Joy; c/o Kalvista Pharmaceuticals Limited, Building 227, Tetricus Science Park, Porton Down, Salisbury SP4 OJQ (GB). STOCKS, Michael John; Elm Tree Farm House, 27 Nether End, Great Dalby, Leicestershire LE14 2EY (GB). DAVIE, Rebecca Louise; c/o Kalvista Pharmaceuticals Limited, Building 227, Tetricus Science Park, Porton Down, Salisbury SP4 OJQ (GB). MARSH, Sally Louise; c/o Kalvista Pharmaceuticals Limited, Building 227, Tetri- cus Science Park, Porton Down, Salisbury SP4 OJQ (GB). HODGSON, Simon Teanby; Orchard House, The Aven- ue, Ampthill, Bedfordshire MK45 2NR (GB). (74) Agents: PHILLIPS, Gillian Margaret et al.; Carpmaels & Ransford LLP, One Southampton Row, London WC1B 5HA (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) = (54) Title: N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN IN- HIBITORS B (I) (57) : The present invention provides a selection of compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kal - likrein activity is implicated); and methods of treating patients with such compounds. 11111111111111011101111111111101111111100111111111110111H01111111111111111110111111 W O 20 16/0838 16 Al