baber/WOPTO huggingface dataset:
Patent DE-68916918-T2 (DE)
Inventor: FORBES IAN THOMSON BEECHAM PHA
IPC: A61K31/535
Filed: 1989-12-07
Granted: 1994-11-03
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: <CHEM>  wherein: R1 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkyl, C2-6 alkenyl or C2-6 alkynyl; R2, R3 and R4 are independently selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkylthio, hydroxy, C2-7 alkanoyl, chloro, fluoro, trifluoromethyl, nitro, amino optionally substituted by one or two C1-6 alkyl groups or by C2-7 alkanoyl, cyano, carbamoyl and carboxy, and phenyl, phenyl C1-4 alkyl or phenyl C1-4 alkoxy in which any phenyl moiety is optionally substituted by any of these groups; R5 and R6 are independently selected from hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, C2-6 alkenyl, C1-7 alkanoyl, C1-6 alkylsulphonyl, di-(C1-6 alkyl)amino C1-6 alkyl, 3-oxobutyl, 3-hydroxybutyl, and phenyl, phenyl C1-4 alkyl, benzoyl, phenyl C2-7 alkanoyl or benzenesulphonyl any of which phenyl moieties are optionally substituted by one or two halogen, C1-6 alkyl, C1-6 alkoxy, CF3, amino or carboxy, or R5 and R6 together are C2-6 polymethylene optionally interrupted by oxygen or NR11 wherein R11 is hydrogen or C1-6 alkyl optionally substituted by hydroxy; R7, R8, R9 and R10 are independently selected from hydrogen, C1-8 alkyl optionally substituted by one or two hydroxy, oxo, C1-4 alkoxy, halogen or CF3 groups, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, C2-7 alkanoyl, C2-6 alkenyl or C2-6 alkynyl either being optionally substituted by one, two or three halogen atoms or C1-4 alkyl, C3-7 cycloalkenyl optionally substituted by one or two halogen or C1-4 alkyl groups, C3-7 cycloalkenyl-C1-4 alkyl in which the cycloalkenyl ring is optionally substituted by one or two halogen or C1-4 alkyl groups, and phenyl optionally substituted by one or two halogen, C1-6 alkyl, C1-6 alkoxy, CF3, amino or carboxy, or R7 and R8 together and/or R9 and R10 together are C3-6 polymethylene optionally substituted by C1-6 alkyl or C2-6 alkenyl; and Z is (CR14R15)n where n is 0, 1 or 2 and R14 and R15 are independently selected from hydrogen, C1-6 alkyl or C2-6 alkenyl.
Patent DE-68918331-T2 (DE)
Inventor: TANAKA SADAO
IPC: C07K14/535
Filed: 1989-06-02
Granted: 1995-05-18
Abstract: Crystalline human granulocyte colony stimulating factor (crystalline G-CSF) and a process for preparation of the same are disclosed. Crystalline G-CSF is extremely pure and exhibits high activity and low antigenicity. In addition, the crystallization of G-CSF improves its stability and makes handling thereof easy when storing and formulating it into desired dosage forms of drugs.
Patent DE-68918899-T2 (DE)
Inventor: SAUVINET VINCENT
IPC: B32B17/10
Filed: 1989-07-25
Granted: 1995-05-11
Abstract: The invention relates to the electrical powering of a window covered with an electrically conductive layer and comprising a sheet of a transparent material of the PVB, PU, PVC type, which adheres to the layer. The invention proposes to bring the electric current to the layer by metallic foils flattened against the layer by the sheet of material of the PVB, PU, PVC type. The invention applies to the construction of windscreens with heating layers for automobiles. <IMAGE>
Patent DE-68927175-T2 (DE)
Inventor: NORMAN ROLF
IPC: H05B37/03
Filed: 1989-10-09
Granted: 1997-01-30
Abstract: In an arrangement for supervising and controlling field light units (20) at an airport, a regulator provided with a monitoring unit for power supply and for monitoring the light units is arranged individually for each light unit (18,20) to regulate the light intensity of the light units and to receive information as to their operational status. In a preferred embodiment, each light unit comprises two separate light sources that can be alternately and separately connected into circuit in case of failure to either of the light sources. Each light unit is provided with an electronic unit including a regulator, monitoring unit, and modem for power supply to the light unit and for monitoring the operation of the light unit. Each light unit is individually addressable from a control central for the airport. A ground traffic control system can be integrated into the field lighting system by connecting suitable presence detectors to the system.
Patent DE-68928303-T2 (DE)
Inventor: NEBESH EUGENE
IPC: B01J27/04
Filed: 1989-03-22
Granted: 1998-03-26
Abstract: A carrier for a hydrotreating catalyst, useful in the production of lubricating oils from crude hydrocarbon oil stocks, is prepared by mixing alumina and a solution of fluosilicic acid and a mineral acid followed by extrusion, drying and calcining. The resultant carrier may be impregnated with a solution of metal components and then calcined and optionally sulfided, to give a catalyst that comprises at least one Group VI metal, metal oxide, or metal sulfide, and at least one Group VIII metal, metal oxide, or metal sulfide, supported on the carrier, wherein (A) the catalyst comprises from 10% to 35% by weight of combined metal, and the atomic ratio of the Group VIII metal to Group VI metal is from 0.5:1 to 2:1; (B) the carrier comprises from 0.5 to 10 weight percent of fluorine, from 0.5 to 5% by weight of silica and from 85 to 99% of alumina; and (C) the catalyst has a median pore radius of from 30 to 65 Angstroms, and a surface area of from 120 to 180 m²/g.
Patent DE-69009867-T2 (DE)
Inventor: NEDZU SHIGERU
IPC: C08L67/02
Filed: 1990-07-06
Granted: 1994-12-08
Abstract: Heat-sealable films formed of a polybutylene terephthalate resin composition including between 50 and 95% by weight of a polybutylene terephthalate base resin having an intrinsic viscosity of 0.7 or greater, and between 5 and 50% by weight of a polycarbonate resin having an intrinsic viscosity of 0.4 or greater melt blended with the polybutylene terephthalate base resin.
Patent DE-69012721-T2 (DE)
Inventor: VAN WINGERDEN ANTONIUS JOHANNE
IPC: B01J8/02
Filed: 1990-09-05
Granted: 1995-01-19
Abstract: This invention relates to a method of conducting a chemical reaction in the presence of a heterogeneous catalyst, in which a feedstock is passed through a catalytic reactor, said reactor comprising a solid reactor bed with a catalytically active material present thereon, and at least one heat supplying and/or discharging reactor wall, and in which the catalyst bed consists of elementary particles of material sintered together and to one side of the wall, there being no sintered material present on the other side of the reactor wall, and in which the maximum distance in meters (xmax) of any point of the reactor bed to a nearest heat supplying and/or discharging wall is determined by the following formula: <MATH>  in which lambda  is the effective coefficient of heat conductivity in W/mK of the sintered material and has a value between 2 and 250; alpha i is the coefficient of heat transfer in W/m<2>/K on the reactor side of the heat supplying and/or discharging reactor wall and equals  epsilon   alpha , where  epsilon  has a value of between 1.0 and 10 and indicates the increase in heat transfer by sintering the material, and  alpha  is the coefficient of heat transfer from the reactor bed in the non-sintered state; DELTA Tmax, measured across a radial cross-section through the reactor bed, is the absolute value of the difference in temperature between any point in this cross-section and the nearest heat supplying and/or discharging reactor wall, the maximum permissible value of which ranges between 1 and 1000 K; a is a form factor determined only by the geometrical shape of the reactor and has a value between 0.25 and 0.5, respectively; a min  is a form factor representing the ratio between the area of the reactor cross-section and the heat exchanging circumference of said reactor cross-section multiplied by xmax and has a value between 0.5 and 1; and q is the maximum reaction heat, in W/m<3>, generated in the reactor bed and which must be supplied and/or discharged through the wall in radial direction.
Patent DE-69015906-T2 (DE)
Inventor: BUECHNER WERNER
IPC: C08G61/10
Filed: 1990-06-29
Granted: 1995-06-22
Abstract: Substituted 1-thiophenes of general formula <IMAGE>  in which:   - R denotes a hydrogen atom or an aliphatic group containing from 1 to 4 carbon atoms, - X and Z may be identical or different and denote a hydrogen atom or a fluorine atom, - Y denotes an at least partially fluorinated aliphatic or aromatic group,   - m denotes an integer equal to or greater than 1,   - n denotes an integer such that 0 </= n </= 12.   The invention also relates to electrically conductive polymers containing repeat units derived from monomers chosen from the substituted thiophenes.
Patent DE-69019671-T2 (DE)
Inventor: HASEGAWA KENJI
IPC: B41J2/14
Filed: 1990-02-28
Granted: 1995-12-14
Abstract: An ink jet head is furnished with an electrothermal transducer which has a heat-generating resistor (1). (1), when energised, generates thermal energy, which is utilised for direct heating of an ink on a thermal action plane and thus for jetting the ink. The heat-generating resistor (1) is made of a material contg. Ir, Ta and Al. The component material of (1) is a non-monocrystalline, polycrystalline or amorphous substance, or a mixt. of these. It contains O,C,N,Si,B,Na,Cl or Fe as impurities. (1) has a structure consisting of a laminated plurality of layers. The electrothermal transducer is furnished with a pair of electrodes to conduct electricity to (1) when it is in contact with (1). The thermal action plane comprises (1) alone or (1) and a protective layer formed on it. The protective layer comprises a Ta layer forming the thermal action plane, (1), and an Si insulating layer existing between (1) and the Ta layer. (1) is 300 Angstroms - 1 micron thick (pref. 1000-5000 Angstrom). An ink jet device is equipped with the ink jet head.
Patent DE-69019956-T2 (DE)
Inventor: SZABO JANOS
IPC: A61K35/744
Filed: 1990-10-05
Granted: 1995-11-23
Abstract: The present invention relates to pharmaceutical compositions for the treatment of skin diseases, especially pyogenous and atopic dermatitis as well as a process for preparing the same. The compositions according to the invention comprise at least three of the lysates of the following bacteria: Haemophilus influenzae, Diplococcus pneumoniae, Klebsiella pneumoniae, K. ozaeneae, Staphylococcus aureus, Streptococcus pyogenes, Str. faecalis, Str. viridans, Escherichia coli and Neisseria catarrhalis. Another aspect of the invention is the use of at least three of the above lysates in the treatment of pyogenous an atopic dermatitis.
Patent DE-69021739-T2 (DE)
Inventor: HEYN WILLIAM
IPC: B29C45/14
Filed: 1990-12-18
Granted: 1996-02-22
Abstract: A closure for a container, and a method for producing the same, wherein the closure includes an end panel and a plastic frame member connected together and which can be place over, or snapped onto, and then the frame member can be permanently attached and hermetically sealed to the flange of a metal, glass, plastic or composite container or can. The interface of the end panel and frame member is such as to hermetically, seal the container and yet the end panel can be readily peeled from at least a portion of the frame member for gaining access to the interior of the container. A pull tab, or ring, is provided to assist in peeling the end panel to an open position. Depending on the manner of attaching or securing the end panel to the frame member, separation or peeling can result from an adhesive failing or from a cohesive failing of the material forming the frame member, or the end panel, or the adhesive.
Patent DE-69105390-T2 (DE)
Inventor: LANDY MICHAEL A
IPC: F16B19/02
Filed: 1991-07-25
Granted: 1995-04-20
Abstract: A circular opening (48) is formed in a structural wall (12). A tubular shank (28) of a nut mounting grommet (26) is inserted into the opening (48). The grommet (26) is moved endwise to place a shoulder surface on the base of a nut mounting cup (30) against the wall (12). A split sleeve is installed on a small diameter portion of a mandrel and the mandrel and sleeve are inserted into the tubular shank (28) from the side of the wall (12) opposite the nut receiving cup (30). The mandrel portions exert a radially outwardly expanding force on the split sleeve. The split sleeve in turn imposes a radially outwardly expanding force on the tubular shank (28). This causes a plastic deformation of the tubular shank (28), creating a tight interference fit between the tubular shank (28) and the sidewall of the opening (48). In this manner, the grommet (26) is firmly secured to the wall (12). Next, a nut (24) is inserted into the cup (30) with its threaded central opening (18) in alignment with the passageway through the tubular shank (28). <IMAGE>
Patent DE-69106043-T2 (DE)
Inventor: BRON ALPHONSE
IPC: G04F7/08
Filed: 1991-05-15
Granted: 1995-08-03
Abstract: The present invention relates to a gear mechanism for a time-piece. 
<??>The aim of the invention is to produce a gear mechanism enabling not only one of the runners (gears) forming it to be brought back into a position of origin, but also a second runner (gear) to be driven, while reducing the height of the said mechanism and the number of pieces necessary to perform these two functions. 
<??>This aim is achieved with the aid of a mechanism comprising a first runner (gear) (24) and a second runner (gear) (34), the first runner (gear) (24) comprising a toothed wheel (30) mounted on a spindle (26) and on which is fixed a heart-shaped cam (32), the point (38) of this cam (32) acting as a meshing means of the second runner (gear) (34) and the cam (32) enabling the said first runner (gear) (24) to be brought back into a position of origin, by virtue of a hammer (36). 
<??>The invention is intended particularly for chronographs. 
<IMAGE>
Patent DE-69106324-T2 (DE)
Inventor: BERTOLI DOMENICO
IPC: B21C33/00
Filed: 1991-05-29
Granted: 1995-05-11
Abstract: A method for feeding billets in horizontal extruding presses which comprises the opening of the container (12), the cutting off of the surplus of the extruded billet simultaneously to the supplying of a new billet (13) in line with the container (12) and to a simultaneous withdrawal of the press shank (17) after each extruding operation and with the withdrawl of the main piston (14a); then the advancing of the pusher (16a) for the insertion of a new billet (13) into the container (12) which is still open and the simultaneous withdrawal of the billet shear (15) and of the feeder means for the supplying of the billet (13); the closing of the container (12) when the pusher (16a) retracts and the movement of the press shank (17) on the axis of the container (12); finally the advancing of the main piston (14a) for the inserting of the press shank (17) into the container (12) for the extrusion operation. <IMAGE>   <IMAGE>
Patent DE-69111149-T2 (DE)
Inventor: DEGELAEN JACQUES
IPC: C12Q1/37
Filed: 1991-04-26
Granted: 1995-12-07
Abstract: It entails the following stages: 1) incubation of the biological fluid with the soluble D-alanyl-D-alanine carboxypeptidase produced by the strain Actinomadura R39; 2) incubation of the mixture obtained with a solution of substrate, which is a thioester of formula 
<IMAGE>
 in the presence of an amino acid of D configuration or glycine; 3) determination of the quantity of 2-mercaptoalkanoic acid of formula 
<IMAGE>
 formed in stage 2); 4) comparison of the determination of stage 3) with a standard. 
<??>In these formulae: 
 
  R1 = benzoyl, phenylacetyl or Nalpha-acetyl-Llysyl, 
  R2 = glycyl or D-alanyl, and 
  R3 = H or CH3. 
 
<??>The invention also relates to a test kit comprising the reagents to be employed for implementation of the method.
Patent DE-69112049-T2 (DE)
Inventor: HEMBREE RICHARD
IPC: B01D35/02
Filed: 1991-04-01
Granted: 1996-01-11
Abstract: A manually operable water purification system which includes (i) a first container divided by a filter into a first chamber for retaining contaminated water and a second chamber retaining a porous body of biocidally effective material, and a plunger sealably receivable within the first chamber for forcing contaminated water retained within the first container through the filter and the porous body of biocidally effective material. The filter permits passage of smaller microbiological pathogens which may be effectively chemically controlled, such as bacteria and viruses, while preventing passage of larger microbiological pathogens which are difficult to chemically control, such as cysts.
Patent DE-69114210-T2 (DE)
Inventor: EFFLAND RICHARD CHARLES
IPC: C07D213/60
Filed: 1991-08-08
Granted: 1996-05-02
Abstract: This invention relates to compounds of the formula <CHEM>  where   R1   is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl; R2   is hydrogen, loweralkyl, loweralkenyl, formyl or cyano; R3   is hydrogen or loweralkyl; R4   is loweralkyl, arylloweralkyl, cycloalkyl, aryl, heteroaryl, heteroarylloweralkyl, <CHEM>  or NR3R4 taken together constitute <CHEM>   R5   is hydrogen, loweralkyl or aryl; R6   is hydrogen, loweralkyl, aryl, arylloweralkyl, formyl, loweralkanoyl or arylloweralkanoyl, X and Y   are independently hydrogen, nitro, amino, halogen, loweralkyl, loweralkoxy or hydroxy; or the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof.   The compounds of this invention are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
Patent DE-69114423-T2 (DE)
Inventor: FAVRE PIERRE
IPC: A61M1/00
Filed: 1991-03-28
Granted: 1996-06-20
Abstract: PCT No. PCT/CH91/00081 Sec. 371 Date Dec. 2, 1991 Sec. 102(e) Date Dec. 2, 1991 PCT Filed Mar. 28, 1991 PCT Pub. No. WO91/15149 PCT Pub. Date Oct. 17, 1991.The device consists of a permanent module (10) and a removable cassette (11). The permanent module comprises a housing (12) with control keys (13) and physical value indicators (14), and two drive hubs (20, 21) for driving two peristaltic pumps mounted in a cassette. The inlet duct (15) of the first pump is connected to a container of physiological liquid, the outlet duct (16) of this pump supplies said liquid to the operating zone, and the duct (17) of the second pump is connected to an operating instrument to drain off the liquid, the duct (18) of this second pump being coupled with a drainage circuit.
Patent DE-69118552-T2 (DE)
Inventor: LEOPARDI EMMETT
IPC: B41F5/24
Filed: 1991-10-28
Granted: 1996-10-31
Abstract: This invention relates to an anilox printing apparatus (20) for depositing ink onto a substrate (23) in a predetermined pattern. The apparatus (20) has a reservoir (22) provided with a weir (30) so that ink (24) may continuously overflow the top or end of the weir (30) and be removed from the reservoir (22) in a controlled fashion while maintaining a constant backpressure of ink (24) in the reservoir (22). This arrangement provides the advantage that ink leakage and splashing caused by debris entering the nip associated with a doctor blade (26) held against the anilox roll (25) or by surface imperfections interfering with the seal formed by such a doctor blade (26) are eliminated. This also provides a printing apparatus (20) for complete coating of the periphery of the anilox roll (25) with ink (24) without a high pressure system.
Patent DE-69118859-T2 (DE)
Inventor: GAMMANS RICHARD
IPC: A61P25/20
Filed: 1991-11-29
Granted: 1996-09-05
Abstract: Certain antidepressants e.g. nefazodone, have been found to alleviate sleeping disorders associated with less than normal REM sleep.
Patent DE-69120783-T2 (DE)
Inventor: EFERL FRANC
IPC: H03M1/36
Filed: 1991-12-10
Granted: 1997-02-06
Abstract: The converter input i is connected through a comparator to the polarity bit output as we @  @  as to the input of a full-wave precision rectifier in the first quantization stage, which like further stages comprises an operational amplifier, a comparator and an exclusive OR gate, the output of which is connected to the output for the first bit. To the inverting input of the amplifier with the gain equal to 2 through the potentiometer a voltage -Uo/2 is fed, (-Uo, +Uo) being the interval of the input voltage. The input of the rectifier is connected to the input i and the input of the rectifier in further stages is connected to the output of the operational amplifier in the previous stage. The second input of the exclusive OR gate is connected to the bit output of the previous stage. <IMAGE>
Patent DE-69122492-T2 (DE)
Inventor: WEBER FRANK
IPC: G03B17/30
Filed: 1991-09-26
Granted: 1997-02-20
Abstract: A reloadable single reel film canister has a housing with first and second parts. The parts are movable, relative to one another, from a closed condition to an open condition. When in the open condition, a roll of film can be placed in the housing. When loaded with film the housing can be reclosed. The amount of film being withdrawn can be monitored by an encoder carried by the canister.
Patent DE-69123754-T2 (DE)
Inventor: SUMNER-SMITH MARTIN
IPC: A61K38/08
Filed: 1991-10-23
Granted: 1997-04-03
Abstract: Described herein are oligopeptides useful to inhibit HIV replication in virally infected individuals. In a preferred embodiment of the invention, the oligopeptide is a D-arginine nonamer having N- and C-terminal protecting groups, which, at a 5  mu m concentration, exhibits greater than 95 % inhibition of HIV replication, in a standard assay.
Patent DE-69132231-T2 (DE)
Inventor: WHITTEN JEFFREY P
IPC: A61K31/155
Filed: 1991-02-26
Granted: 2000-11-30
Abstract: The present invention is directed to a new class of compound which are useful as inhibitors of the biosynthesis of nitric oxide.
Patent DE-69210359-T2 (DE)
Inventor: GUZZINATI ALBERTO
IPC: E05B15/10
Filed: 1992-09-29
Granted: 1996-11-07
Abstract: A security lock for doors of dwellings, gates and the like comprises a pump-type locking mechanism (8) for operating a bolt (2), and a double-bit locking mechanism (34) for locking the pump mechanism (8) in its locking condition. The lock preferably has both a key (10) which can operate only the pump mechanism (8) and a key (10, 10a, 10b) which can operate both mechanisms (8, 34). A cover (52) made of plastics material is associated with the key (10) and can be fitted onto the operative portion of the key (10) in order to protect its teeth (10a, 10b) against dirt and against the risk of breakage as a result of the key being dropped. <IMAGE>
Patent DE-69213195-T2 (DE)
Inventor: BAUMULLER THEODORE
IPC: B65D30/18
Filed: 1992-12-21
Granted: 1997-04-03
Abstract: The subject of the present invention is a sealed, washable packaging bag, its corresponding method of manufacturing and the machine for forming its base. Gussetless sealed, washable packaging bag, made from a complex whose internal face is heat-weldable, characterised in that it comprises a sealed rectangular bottom (2), which has no internal corner, essentially consisting of two lateral tabs (3, 3') cut out from the tube (4) constituting the body of the bag, which are folded transversely inwards and assembled, by welding, on the one hand, together at their free ends, and, on the other hand, along their longitudinal edges, with the bases (7) of two middle tabs (6, 6'), also cut out from the tube (4), the latter being folded down and adhesively bonded onto the said lateral tabs (3, 3') when assembled, so as at least partially to overlap. <IMAGE>
Patent DE-69213964-T2 (DE)
Inventor: LEE DAVID
IPC: A01N41/10
Filed: 1992-07-29
Granted: 1997-02-06
Abstract: The compound 2-(2-chloro-3-ethoxy-4-ethylsulfonyl)-5-methyl-1,3-cyclohexanedione or its salts as a herbicide.
Patent DE-69222539-T2 (DE)
Inventor: VOS PETER
IPC: B65G47/252
Filed: 1992-12-18
Granted: 1998-02-26
Abstract: A conveyor apparatus including dips to turn and tumble items placed on the conveyor. The conveyor apparatus has a conveyor belt configured in a series of dips arranged to ensure the turning and tumbling of items placed on the conveyor belt.