baber/WOPTO huggingface dataset:
Patent NZ-572403-A (NZ)
Title: Rnai modulation of apob and uses thereof
Inventor: SOUTSCHEK JUERGEN
IPC: A61K31/70
Filed: 2005-09-26
Abstract: Disclosed is an iRNA agent comprising a sense strand having at least 15 contiguous nucleotides of sense strand sequence of a specified sequence and an antisense strand having at least 15 contiguous nucleotides of the antisense sequence. Further provided are modified forms of the RNAi agents and methods of making them as well as corresponding pharmaceutical compositions.
Patent NZ-572581-A (NZ)
Title: Novel fetal markers for prenatal diagnosis and monitoring
Inventor: LO YUK MING DENNIS
IPC: C12Q1/68
Filed: 2007-05-03
Abstract: Disclosed is a method for detecting or monitoring a pregnancy-associated disorder in a woman pregnant with a fetus, comprising the steps of: (a) determining the methylation status of a CpG-containing genomic sequence in a biological sample from the woman, wherein the sample is whole blood, serum, plasma, urine, or saliva, wherein the genomic sequence from the fetus and the genomic sequence from the woman are differentially methylated, thereby distinguishing the genomic sequence from the woman and the genomic sequence from the fetus in the sample, wherein the genomic sequence is at least 15 nucleotides in length, comprising at least one cytosine, and is within a region on chromosome 21, and wherein the region consists of (1) a genomic locus ofCGI137; and (2) a DNA sequence of no more than 10 kb upstream and/or downstream from the locus; (b) determining the level of the genomic sequence from the fetus; and (c) comparing the level of the genomic sequence from the fetus with a standard control, wherein an increase from the standard control indicates the presence or progression of a pregnancy-associated disorder.
Patent NZ-574154-A (NZ)
Title: Apparatus for generating electric power using wind energy
Inventor: CHUNG CHUN-NENG
IPC: F03D3/00
Filed: 2009-01-12
Abstract: A blade unit 5 with an upright rod 51 is rotatable about a central axis. A generator 6 in the base 3 of the apparatus is coupled to the lower end of rod 51. A wind-collecting cover 4 is mounted rotationally to base 3 with opposed ends being wind inlet 411 and wind outlet 412 (of a smaller size than the inlet) such that the cover rotates in response to wind direction.
Patent NZ-576562-A (NZ)
Title: Installation monitoring for connectors
Inventor: THOMPSON ANDREW JAY
IPC: F16B31/00
Filed: 2009-04-28
Abstract: A connector having a torque-off shear head is provided with a visually distinctive cover that extends over and is secured to the structural core of the shear head. The torque applying tool is applied to the cover to apply a torque to the head so that when the head is sheared from the main body of the connector the cover remains secured to the head so that it is readily apparent by the absence of the visually distinctive cover that the connector has been tightened to the predetermined torque value. The invention is especially valuable to indicate the proper tightening of the screws of heavy current electrical connectors.
Patent NZ-577563-A (NZ)
Title: Method for configuring the link maximum transmission unit (mtu) in a user equipment (ue)
Inventor: KUNINGAS TARMO
IPC: H04L47/36
Filed: 2008-02-05
Abstract: A user equipment (UE) is adapted to connect to a System Architecture Evolution / Long Term Evolution (SAE/LTE) radio network. The UE comprising means for receiving data. The means for receiving data comprises the link maximum transmission unit (MTU) supported by the SAE/LTE network. The means comprises one of means for receiving the link MTU in a Non Access Stratum (NAS) message and means for receiving the link MTU in a Radio Resource Control (RRC) message. A method of configuring the link maximum transmission unit (MTU) in a user equipment (UE) adapted to connect to an System Architecture Evolution / Long Term Evolution (SAE/LTE) radio network and a node in a System Architecture Evolution/Long Term Evolution (SAE/LTE) radio network is disclosed. The node comprises means for signalling the MTU supported by the SAE/LTE network to a User Equipment (US) connected to the network. The means comprises one of means for signalling the link MTU in a Non Access Stratum (NAS) message and means for signalling the link MTU in a Radio Resource Control (RRC) message.
Patent NZ-577812-A (NZ)
Title: An insulinotropic exendin-4 complex using an immunoglobulin fragment
Inventor: SONG DAE HAE
IPC: A61P3/08
Filed: 2008-01-04
Abstract: Disclosed is an insulinotropic peptide conjugate, comprising: an insulinotropic peptide and an immunoglobulin Fc region, which are linked by a non-peptidyl polymer, wherein the insulinotropic peptide is selected from the group consisting of: exendin-4, an exendin-4 derivative prepared by deleting N-terminal amine group, an exendin-4 derivative prepared by substituting N-terminal amine group with hydroxyl group, an exendin-4 derivative prepared by modifying N-terminal amine group with dimethyl group, an exendin-4 derivative prepared by deleting á-carbon of histidine, the first amino acid of exendin-4, an exendin-4 derivative prepared by substituting 12th amino acid(lysine) for serine, and an exendin-4 derivative prepared by substituting 12th amino acid(lysine) with arginine, wherein the nonpeptidyl polymer is selected from the group consisting of: polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof, and wherein one end of the non-peptidyl polymer is linked to an amino acid residue other than the N-terminus of the insulinotropic peptide. Further disclosed is an insulinotropic peptide conjugate represented by the following Chemical Formula 1: R1-X-Y-Z-R2 wherein, R1 is selected from the group consisting of histidine, des-aminohistidyl group, N-dimethyl-histidyl group, beta-hydroxy imidazopropyl group and 4-imidazoacetyl group; R2 is selected from the group consisting of -NH2, -OH and -Lys; X is selected from the group consisting of GIy-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser, GIy-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly, and Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser, wherein R3 is selected from the group consisting of Lys, Ser and Arg; and R4 is selected from the group consisting of Lys, Ser and Arg; Y is polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof; and Z is an immunoglobulin Fc region.
Patent NZ-582437-A (NZ)
Title: Front wheel drive bicycle with the front fork coupled to the steering mechanism without passing through the fixed head tube
Inventor: REYES RODOLFO RUDY
IPC: B62M1/36
Filed: 2008-06-13
Abstract: A vehicle 100A, comprises a front wheel 110 and a back wheel 108, a front fork 114, a frame, a crank 120 and a steering mechanism where the front fork 114 is operable for steering the vehicle 100A by moving the front wheel 110. The front fork 114 and the back wheel 108 are operably coupled to the frame. The front fork 114 is connected to a fixed head tube 104 of the frame. The crank 120 provides power to the front wheel 110, and is positioned between a front wheel 110 and the back wheel 108. A movable linkage conveys the power from the crank 120 to the front wheel 110, and is at least partially enclosed within the frame between the crank 120 and the front wheel 110. The front fork 114 is rigidly coupled to the steering mechanism without passing through the fixed head tube 104.
Patent NZ-588587-A (NZ)
Title: Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
Inventor: KAO KUO-JANG
IPC: C07K16/28
Filed: 2009-03-18
Abstract: Provided are specific antibodies against PVAP protein. The antibodies can be used to diagnose liver cancer and for treatment of hepatocellular carcinoma (HCC), wherein the PLVAP antagonist inhibits an activity selected from the group consisting of tumor formation, tumor growth, tumor vascularisation, and tumor progression in the liver.
Patent NZ-592139-A (NZ)
Title: Biodegradable polymer - bioactive moiety conjugates
Inventor: O SHEA MICHAEL SHANE
IPC: C08G67/04
Filed: 2009-10-09
Abstract: 592139 Disclosed is a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, the biodegradable polymer having a general formula (1) where the variables are defined in the specification.
Patent NZ-594772-A (NZ)
Title: Diagnosis and prognosis of renal injury and renal failure using vitamin k dependent protein c
Inventor: ANDERBERG JOSEPH
IPC: C12Q1/02
Filed: 2010-02-05
Abstract: Patent No. 594772 Disclosed is an ex vivo method for evaluating renal status in a subject, comprising: performing an assay configured to detect Vitamin K-dependent protein C in a body fluid sample obtained from the subject to provide an assay result; and correlating the assay result to the renal status of the subject by comparing a measured concentration of Vitamin K-dependent protein C in said assay result to a threshold concentration of Vitamin K-dependent protein C and: (i) assigning a likelihood of an event occurring or determining that an event has occurred when the measured concentration is above the threshold; or (ii) assigning a likelihood of an event not occurring or determining that an event has not occurred when the measured concentration is below the threshold. Also disclosed is the use of an antibody that binds to vitamin K-dependent protein C in a diagnostic test.
Patent NZ-596446-A (NZ)
Title: Inflatable hull configuration and connection for a multihull vessel
Inventor: CONTI UGO
IPC: B63B7/08
Filed: 2010-05-11
Abstract: 596446 Inflatable hull configuration and connection for a multihull watercraft vessel. The watercraft has first and second spaced apart and parallel inflatable hulls (30) supporting a central body (14) on legs there between and above the inflatable hulls (30). Each inflatable hull (30) has a longitudinal structural member extending over the top of the inflatable hull (30) and fastened thereto. The body (14) is supported with respect to each inflatable hull (30) by a stern leg (1) and a forward leg (9). The forward legs (9) are coupled to the central body (14) to allow at least a limited rotation of the forward legs (9) as a unit with respect to the central body (14). A lower end (32) of each forward leg (9) is coupled to a forward part of a respective longitudinal structural member through a spring mounted ball joint. An upper end of each stern leg (1) is rigidly coupled to the central body. A lower end (31) of each stern leg (1) is coupled to a rear part of a respective longitudinal structural member through a joint that allows at least limited rotation about a vertical axis and about a horizontal axis perpendicular to a length of a respective longitudinal structural member, but not about an axis parallel to the length of the respective longitudinal structural member.
Patent NZ-601214-A (NZ)
Title: Pallet for bags
Inventor: SHAW IAN ANDREW
IPC: B66F9/12
Filed: 2011-06-14
Abstract: A pallet (10) is disclosed moulded from plastics material and adapted for supporting and lifting a flexible intermediate bulk storage container bag. The pallet comprises a generally planar central panel portion (12), at least two parallel inverted channels (14, 16) extending across the pallet and, a pair of edge panel portions (18) generally co-planar with the central panel (12). An array of raised elongate first hump portions (37) bulges upwards from and extends laterally across the upper walls (28) of the tunnels (14, 16). The reinforcing hump portions (37) abut first and second buttress which extends up the side walls (24, 26). A further embodiment includes two pairs of channels (14, 16) extending at right angles to allow access to forklift tines from each side of the pallet.
Patent NZ-601993-A (NZ)
Title: Seal for an ostomy appliance
Inventor: WEIG BRET
IPC: A61F5/445
Filed: 2008-02-21
Abstract: 601993 An ostomy appliance comprising an inflatable seal (20) for forming a seal at a stoma (22), the inflatable seal comprising: a first inflatable chamber portion for insertion into the stoma for forming an internal seal; a second inflatable chamber for forming an external seal with respect to the stoma; and a discharge portion (28) extending through the first and second chamber portions. The discharge portion is defined at least partly by an inflatable support (28a) coupled to at least one of the first and second chamber portions, the discharge portion having stiffness greater than the first and second chamber portions.
Patent NZ-603309-A (NZ)
Title: Diaphragm valve sealing arrangement
Inventor: COLLINS PHILIP JOHN
IPC: F16K47/02
Filed: 2010-06-04
Abstract: 603309 A float valve comprising: a valve body having a hole from an interior of the body to an exterior of the valve and a rim projecting about the hole and having at least one opening, a float arm pivotally coupled to the body adjacent the hole and adaptable to be coupled to a float at one end of the arm for pivoting the arm, and a sealing member associated with the float arm and moveable with the arm such that in a first pivotal position of the float arm the sealing member contacts the rim without closing the hole thereby enabling fluid to flow from the hole through the opening of the rim to the exterior of the valve, and further pivotal movement of the float arm to the closed position causes the sealing member to compress against the rim and move towards the hole to close a fluid passage between the hole and the opening and prevent fluid from flowing from the interior of the body to the exterior of the valve.
Patent NZ-609386-A (NZ)
Title: Shower door assembly
Inventor: WEI WUXIANG
IPC: E05C21/02
Filed: 2013-04-15
Abstract: A shower door assembly is provided which comprises a stationary frame, and a movable frame having a guiding groove, wherein the shower door assembly further comprises a fixing block disposed in the stationary frame, the fixing block has a channel and a cam mechanism rotatable about a portion of the fixing block, a first engaging element is provided on at least a part of a bottom surface of the channel, and the shower door assembly further comprises an adjusting block disposed in the guiding groove of the movable frame, the adjusting block has an extension part insertable into the channel of the fixing block, the extension part has a second engaging element, wherein when a force is applied to the extension part by the cam mechanism, the first and second engaging elements are engaged such that the stationary and movable frames do not displace.
Patent NZ-611977-A (NZ)
Title: Augmenting personal availability using a mobile device
Inventor: ESTEVE BALDUCCI JUAN V
IPC: H04W4/12
Filed: 2011-12-07
Abstract: A method of augmenting an online presence by leveraging mobile computing device (2) sensors (40) is disclosed. The method comprises the step of the mobile computing device (2) receives at least one of state change data (60) and rate of change data (62) measured by the mobile computing device (2) sensors (40). The mobile computing device (2) compares the at least one of state change data (60) and rate of change data (62) with a set of rules (50) to determine a matching online presence state. The set of rules (50) is configured to associate a plurality of online presence states with a plurality of instances of measured sensor data. The measured sensor data comprises data attributes and communication usage data associated with the mobile computing device (2). The mobile computing device (2) updates an online presence associated with the user of the mobile computing device (2) with the matching online presence state (52).
Patent NZ-612201-A (NZ)
Title: Passive heat extraction and power generation
Inventor: SCHWARCK MATTHEW N
IPC: F24J3/08
Filed: 2011-12-12
Abstract: Disclosed is a closed-loop system (10) for harnessing subterranean heat energy from a selected subterranean zone (15) having a quantity of subterranean material to a surface location. Included is a first well bore (30) with a first substantially vertical well bore section (42) from the surface location to the selected subterranean zone (15) and at least a first angled well bore section (44) extending from the first substantially vertical section (42) into at least a portion of the selected subterranean zone (15). A first substantially vertical transfer section (40) has an outer casing (38) located within the first substantially vertical well bore section (42). A first passive heat transfer device (34) extends away from the substantially vertical transfer section (42) within the second section of the wellbore. The first passive heat transfer device (34) has an outer casing (46) and an inner tubing (50). The outer casing (46) is connected to the substantially vertical transfer outer casing (38) and has a sealed end (34’). At least a portion of the outer casing has a rifled configuration, and the inner tubing (50) is configured within the outer casing in a concentric arrangement defining a first fluid path in an annulus space between the outer casing and the inner tubing (50). The first passive heat transfer device (34) has a second fluid path within the inner tubing (50) and the inner tubing (50) has an open end (52) proximate the sealed end (34’) of the outer casing such that the first and second fluid paths are in fluid communication. A working fluid is located within the first and second fluid paths and an output apparatus receives a heated working fluid from the selected subterranean zone (15).
Patent NZ-617642-A (NZ)
Title: Pyrazole derivatives useful as aldosterone synthase inhibitors
Inventor: BELL MICHAEL GREGORY
IPC: C07D231/56
Filed: 2012-06-07
Abstract: Disclosed are aldosterone synthase inhibitors of the formula (I) and pharmaceutical salts thereof: intermediates, methods for their preparation, pharmaceutical preparations, and methods for their use, particularly in the treatment of chronic kidney disease and diabetic nephropathy. Particularly preferred compounds are 4-(6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl)benzonitrile and 4-(6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-y1)-3-fluoro-benzonitrile.
Patent NZ-619488-A (NZ)
Title: A synergistic pharmaceutical combination for the treatment of squamous cell carcinoma of head and neck
Inventor: AGARWAL VEENA
IPC: A61P35/00
Filed: 2012-05-30
Abstract: Disclosed herein is a pharmaceutical combination for use in the treatment of squamous cell carcinoma, comprising a CDK inhibitor selected from benzopyran (chromene) compounds of formula (I), wherein the substituents are as defined in the specification; and one or more antineoplastic agents selected from sorafenib, lapatinib, erlotinib, cisplatin, 5-fluorouracil, docetaxel or cetuximab. The said pharmaceutical combination exhibits synergy when used in the treatment of squamous cell carcinoma of head and neck (SCCHN). Also disclosed is the use of the pharmaceutical composition comprising the said combination for the manufacture of a medicament for the treatment of squamous cell carcinoma of head and neck (SCCHN).
Patent NZ-624287-A (NZ)
Title: Improvements in, or relating to, fasteners
Inventor: STOTHERS PETER ALLAN
IPC: F16B13/04
Filed: 2011-10-31
Abstract: A blind fastener to engage and hold a first member (2, 24) to a second member (4, 25). The fastener has a clip member (3) adapted to install into a first aperture on the first member, the clip member having, a main body and a clipping tongue biased away from the body to engage the aperture. The clip also has a mounting portion (9) extending outwardly. A washer member (10) passes over the mounting portion. The washer has an extension to pass between and wedge the main body and the clipping tongue apart. A fastener (13) then engages the mounting portion to secure the clip member, washer, and second member, to the first member.
Patent NZ-627990-A (NZ)
Title: Branched polymers for complex formation with nucleic acids
Inventor: GUNATILLAKE PATHIRAJA ARACHCHILLAGE
IPC: C08G83/00
Filed: 2013-02-01
Abstract: Disclosed are branched polymers comprising a support moiety and at least three block co-polymer chains covalently coupled to and extending from the moiety, wherein: (i) each of the at least three block co-polymer chains comprise (a) a cationic polymer block that is covalently coupled to a hydrophilic polymer block, or (b) a cationic polymer block that is covalently coupled to a hydrophobic polymer block, said hydrophobic polymer block being covalently coupled to a hydrophilic polymer block; and (ii) at least one of said covalent couplings associated with each of said block co-polymer chains is biodegradable. Also disclosed are branched polymers coupled to a nucleic acid molecule.
Patent NZ-630317-A (NZ)
Title: Extracts and beverages containing 2, 5-piperazinedione, 3, 6-bis (phenylmethyl) -, (3s, 6s) -
Inventor: WATANABE HIROSHI
IPC: A61K9/48
Filed: 2010-02-26
Abstract: Disclosed are extracts or beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S)-, and having a pH of 5 and have a ratio between the content of 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S)-(unit:μg/100g)and Brix(Bx)is 6(μg/100g)/Bx or more. The extracts and beverages can be ingested continuously over a long period of time as foods and beverages useful for improvement of learning motivation.
Patent NZ-704650-A (NZ)
Title: Electrical heater with particular application to humidification and fluid warming
Inventor: ROW NATHAN JOHN
IPC: H05B3/48
Filed: 2008-06-03
Abstract: A humidifier for humidifying a flow of breathable gas, the humidifier comprising: a moulded tub configured to contain a supply of water and comprising: an air inlet for receiving the flow of breathable gas; and an air outlet adapted to connect to a gas conduit and deliver the flow of breathable gas; a heater element (41) configured to heat the supply of water to humidify the flow of breathable gas; and at least one electrical connector (62) moulded into the moulded tub, the at least one electrical connector connecting the heater element to an electrical contact to enable the heater element to be connected to a power supply unit.
Patent NZ-715983-A (NZ)
Title: Vasoprotective and cardioprotective antidiabetic therapy
Inventor: DAIBER ANDREAS
IPC: A61P3/10
Filed: 2011-11-15
Abstract: Use of linagliptin for preparing a pharmaceutical composition for treating patients having metabolic disorders such as diabetes, who are at elevated risk of cardiovascular disorders. Where elevated cardiovascular risk is determined by one or more of the following risk factors: A) previous or existing vascular disease selected from myocardial infarction, coronary artery disease, percutaneous coronary intervention, coronary artery by-pass grafting, ischemic or hemorrhagic stroke, congestive heart failure, and peripheral occlusive arterial disease, B) vascular related end-organ damage selected from nephropathy, retinopathy, neuropathy, impaired renal function, chronic kidney disease, and micro- or macroalbuminuria, C) advanced age >/= 70 years, and D) at least two cardiovascular risk factors selected from - advanced type 2 diabetes mellitus > 10 years duration, - hypertension, - current daily cigarette smoking, - dyslipidemia, and - obesity