baber/WOPTO huggingface dataset:
Patent JP-3015463-B2 (JP)
IPC: C12N15/09
Filed: 1993-04-28
Granted: 2000-03-06
Abstract: It has been discovered that any RNA can be targeted for cleavage by RNAase P from eukaryotic cells, for example, human HeLa cells, using a suitably designed oligoribonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNAase P in vitro. There are two classes of EGS that can target RNA for cleavage by human RNAase P. These are prepared by transcription from a small DNA fragment that contains a sequence coding for an RNA that can assume a tRNA-like secondary structure. In the first class, the structure lacks at least the first thirteen nucleotides from the 5' terminus of the tRNA-like sequence, the anticodon stem and loop, the variable loop or part of the variable loop. The most efficient EGS with human RNAase P is the EGS in which the anticodon stem and loop was deleted. In the second class, the EGS has changes in both the equivalent of the T-loop and the anticodon stem of the tRNA-like segment of the EGS. Methods are also disclosed to randomly select and to express a suitable EGS in vivo to make a selected RNA a target for cleavage by the host cell RNAase P, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease-causing genes in vivo.
Patent JP-3608624-B2 (JP)
IPC: A61P1/00
Filed: 1995-01-09
Granted: 2005-01-12
Abstract: The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula    <IMAGE>  Formula (I)  useful as inhibitors of enkephalinase.
Patent JP-3618346-B2 (JP)
IPC: A61K31/445
Filed: 1994-03-28
Granted: 2005-02-09
Abstract: The composition of the present invention combines the local anaesthetic lidocaine in free base form and the non-CFC aerosol propellant HFC-134a (1,1,1,2-tetrafluoroethane; CF3CH2F) or HFC-227 (1,1,1,2,3,3,3-Heptafluoropropane; CF3CHFCF3), or a combination thereof, thus incorporating previously-unattainable amounts of the lidocaine free base in solution in a non-CFC aerosol propellant. This particular form of relatively-concentrated cosolvent-free anaesthetic permits improved inhalation delivery to the airway and lung, and topical airway local anaesthesia is thus readily provided. A method in accordance with the invention provides for release of the anaesthetic in aerosolized form of selected dosage from a canister containing the pressurized local anaesthetic composition into a patient's respiratory system directly or by way of an airway.
Patent JP-2919975-B2 (JP)
IPC: B21F1/02
Filed: 1995-12-04
Granted: 1999-07-19
Abstract: A pre-straightened metal wire consisting of a copper alloy and having a diameter of less than 6 mm and a mechanical strength of 400-750 MPa is packaged in a cylindrical drum in such a way that, when it is unwound, the wire is straight, with a sag of less than 5 mm per metre, and can be fed directly to a bar turning machine.
Patent JP-4102441-B2 (JP)
IPC: C12R1/91
Filed: 1997-03-12
Granted: 2008-06-18
Abstract: The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or "FAP alpha " and its uses.
Patent JP-4097700-B2 (JP)
IPC: H03F3/217
Filed: 1997-03-26
Granted: 2008-06-11
Abstract: To correct non-linearity and noise in the conversion of a pulse code modulated signal (PCM) into a uniform pulse width modulated signal (UPWM), a model is made of the known non-linearity in the conversion by dividing a plurality of non-linearity components in the model, where the polynomial components are separately weighed with filter coefficients. The model is used as a basis for the construction of a filter of the Hammerstein type whose non-linear parts consist of a division of the PCM signal into a plurality of powers, and whose linear parts are approximated by means of the model made. With the circuit of the invention it is now possible to construct a purely digital amplifier which has a great efficiency, low weight, etc.
Patent JP-3192151-B2 (JP)
IPC: B27N3/28
Filed: 1997-04-10
Granted: 2001-07-23
Abstract: A method for improving the bondability of annual plant materials to a formaldehyde-based resin including the steps of: (a) providing a straw plant material having a plurality of fibers with each of the fibers surrounded by a waxy and silica layer; (b) extruding the straw plant material in a twin screw extruder while simultaneously subjecting the straw plant material to a thermal treatment with an aqueous solution containing a lignin modifying agent or steam, the thermal treatment being conducted at a temperature between about 40° C. and 120° C., the extruding subjecting the straw plant material to a sufficiently high shear force such that the extruding with simultaneous thermal treatment achieves a substantial defibration of the straw plant material with destruction of the waxy and silica layer and formation of individual fibers and (c) subjecting the treated material to heat and pressure in the presence of the formaldehyde-based resin to form a resin-bonded fiberboard or particleboard.
Patent ES-2583631-B2 (ES)
Title: Proceso de despolimerización catalítica de plásticos a baja temperatura con alimentación en continuo, para la conversión en hidrocarburos líquidos y gaseosos
Inventor: DIAZ MONTOYA RUBÉN
IPC: C08J11/16
Filed: 2015-03-20
Granted: 2017-03-17
Abstract: Proceso de despolimerización catalítica de plásticos a baja temperatura con alimentación en continuo, para la conversión en hidrocarburos líquidos y gaseosos.#El proceso de la invención está previsto para realizar la descomposición catalítica de mezcla de residuos plásticos de origen urbano consiguiendo su conversión en hidrocarburos líquidos y gaseosos. Para ello se realiza un pretratamiento de la materia prima que comprende la separación, secado y triturado de residuos, y, posteriormente, se finaliza el pretratamiento con el extrusionado, precalentamiento y homogeneización; todo ello con anterioridad a un proceso de calentamiento en un horno. En el secado previo, el residuo se deja a una humedad inferior al 12%, y con una granulometría inferior a 60 mm. En el extrusionado previo se elimina el oxígeno existente hasta menos del 6% del oxígeno inicial. De manera que el residuo, así pretratado, se mezcla con un catalizador antes de entrar en el horno para una óptima valorización del residuo y su conversión en hidrocarburos líquidos y gaseosos.
Patent AU-2002213261-B2 (AU)
Title: Connector for spinal rod and vertebral anchor
Inventor: YOUNG JOHN STEWART
IPC: A61B17/00
Filed: 2001-10-17
Granted: 2005-10-06
Abstract: A connection assembly between a spinal implant rod and a vertebral anchor. The assembly has a split ring, a clamp, a collet and optionally a nut. The split ring is located inside the clamp and the collet is inserted through each of the clamp's arms. In use, the spinal implant rod is placed inside the split ring and the shaft or shank of the vertebral anchor is placed inside the collet. Drawing the arms of the clamp together then tightens the connection assembly, which closes the collet around the vertebral anchor and closes the split ring around the implant rod. Threading a nut on one end of the collet or directly threading the collet into one of the arms of the clamp tightens the assembly.
Patent AU-2002231697-B2 (AU)
Title: Composition for treatment of inflammatory disorders
Inventor: WAUBEN MARCA HENRIETTE MICHAEL
IPC: A61K47/18
Filed: 2001-12-07
Granted: 2006-09-07
Abstract: A pharmaceutical composition for parenteral administration, comprising liposomes composed of non-charged vesicle-forming lipids, including up to 20 mole percent of an amphipathic vesicle-forming lipid derivatized with polyethyleneglycol, and optionally including not more than 10 mole percent of negatively charged vesicle-forming lipids, the liposomes having a selected mean particle diameter in the size range between about 40-200 nm and containing a water soluble corticosteroid for the site-specific treatment of inflammatory disorders, is provided.
Patent AU-2002328207-B2 (AU)
Title: A process for making rare earth metal oxide-coated microporous materials
Inventor: SNAIDR STANISLAV M
IPC: B01J37/00
Filed: 2002-09-12
Granted: 2008-06-12
Abstract: A process for making a catalytic rare earth metal oxide-coated microporous particulate material that has the rare earth metal oxide coated on outer surfaces of the microporous particulate material. The process comprises the steps of: i) combining an amount of a colloidal dispersion of rare earth metal oxide hydrate with a compatible microporous particulate material to form a slurry, the microporous particulate material having an average pore size less than the particle size of the colloidal dispersion, to position thereby, the colloidal dispersion on the outer surfaces of the microporous particulate material; and ii) heat treating the slurry to fix the rare earth metal oxide to the outer surfaces of the microporous particulate material.
Patent AU-2003266854-B2 (AU)
Title: Recyclable plastics materials
Inventor: WARWICK DAMIEN
IPC: G09F3/10
Filed: 2003-05-08
Granted: 2008-08-28
Abstract: A recyclable plastics material includes a polystyrene compatible label ( 10 ) which is attachable to an object, such as a hanger ( 1 ) which is also manufactured from a polystyrene or a polystyrene compatible material. The main rail hook ( 20 ) is also manufactured from a recyclable plastics material.
Patent AU-2004203910-B2 (AU)
Title: Use of 2-amino-2H-quinazoline derivatives for producing therapeutic agents
Inventor: SACHSE ROLF
IPC: A61K31/517
Filed: 2004-01-07
Granted: 2008-07-31
Abstract: The invention concerns the use of 2-amino-2H-quinazoline derivatives of general chemical formula (I), wherein R1 indicates an alkyl group with 1-5 carbon atoms and R2, R3, R4 and R5, independently of one another, each indicate a chlorine or hydrogen atom, as well as their pharmaceutically compatible salts, for producing therapeutic agents for the treatment of myeloproliferative diseases, high blood pressure and for bronchodilation.
Patent AU-2004255924-B2 (AU)
Title: Thiazolo-, oxazalo and imidazolo-quinazoline compounds capable of inhibiting protein kinases
Inventor: MCINNES CAMPBELL
IPC: C07D413/04
Filed: 2004-07-07
Granted: 2009-07-02
Abstract: A compound of formula 1, or a pharmaceutically acceptable salt thereof, wherein: X is S, O, or NH; "a" is a single bond; or "a" is a double bond and one of R3 and R4, and one of R5 and R6 are absent; R1 is H; or is selected from an alkyl group, a cycloalkyl group, a heteroaryl group, an aralkyl group, CO-alkyl, SO2-alkyl, CO2R13 and an aryl group, each of which optionally contains one or more heteroatoms, and is optionally substituted with one or more groups selected from R8 and R9; R2 is H, R8, or an alkyl group optionally substituted with one or more R8 groups; R3, R4, R5, and R6 are each independently selected from H, R8, an alkyl group and an alkenyl group, wherein said alkyl and alkenyl groups are optionally substituted with one or more R8 groups; or R3 and R4, and/or R5 and R6 together represent -O; R7 is H, R8, NH(CH2)nR9, CO(CH2)nR9, NHCO(CH2)nR9, O(CH2)nR9, or an alkyl or phenyl group, each of which is optionally substituted with one or more groups selected from R8 and R9; R8 is OR10, NR10R11, halogen, CF3, NO2, COR10, CN, COOR10, CONR10R11, SO2R10 or SO2NR10R11; R9 is a saturated or unsaturated 5- or 6-membered cyclic group optionally containing one or more heteroatoms selected from N, O and S, and optionally substituted with one or more R8 groups; R10, R11, R12 and R13 are each independently H or a hydrocarbyl group; and n is 0, 1, 2 or 3. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula 1, and the therapeutic use thereof in the treatment of proliferative disorders, viral disorders, CNS disorders, diabetes, stroke and cardiovascular disorders.
Patent AU-2005211585-B2 (AU)
Title: Bipolar forceps with multiple electrode array end effector assembly
Inventor: ODOM DARREN
IPC: A61B18/14
Filed: 2005-09-19
Granted: 2012-04-05
Abstract: BIPOLAR FORCEPS WITH MULTIPLE ELECTRODE ARRAY END EFFECTOR ASSEMBLY Abstract A bipolar electrosurgical forceps (10) includes first and second opposing jaw s members (280, 282) having respective inwardly facing surfaces associated therewith. The first and second jaw members (280, 282) are adapted for relative movement between an open position to receive tissue (600) and a closed position engaging tissue (600) between the inwardly facing surfaces. The first and second jaw members (280, 282) each include a plurality of electrodes (412, 422) on the inwardly facing surfaces. The plurality of to electrodes (412, 422) of the first jaw member (280) are disposed in substantially vertical registration with the plurality of electrodes (412, 422) of the second jaw member (282). Each of the plurality of electrodes (412, 422) is configured to connect to a source of electrosurgical energy. Electrodes (412, 422) on at least one jaw member (280, 282) are grouped in pairs and each respective pair aligns with at least one electrode on the opposite 15 jaw members. A multiplexer controls current density or activation sequence of the electrosurgical energy to each electrode (412, 422). Cj.
Patent AU-2005212319-B2 (AU)
Title: Shaving razors, and blade subassemblies therefor and methods of manufacture
Inventor: AVIZA GREGORY D
IPC: B26B21/00
Filed: 2005-02-08
Granted: 2009-03-26
Abstract: A subassembly for a shaving razor including a plurality of elongated metal blades. The blades having cutting edges defining a shaving surface longitudinal ends and are secured at their longitudinal ends to first and second plastic blocks to provide an integral unit.
Patent AU-2005326343-B2 (AU)
Title: A self destruction disposable syringe
Inventor: LIN ZUOQIAN
IPC: A61M5/50
Filed: 2005-03-28
Granted: 2010-12-16
Abstract: The present invention provides a safety self-destroying disposable syringe, which consists of a hollow tube, a plunger fitting into the inside of the hollow tube and a rubber piston attached on the tip end of the plunger, and a needle holder attached on the front end of the hollow tube, wherein said needle holder is comprised of a cone base and a seat; said cone base has a Roll cone for fitting into the needle, and a circular base for fitting into the inside of the hollow tube, there are several O-rings attached on the contacting surface between them; there is a locating ring-groove built on the inside wall of the hollow tube approaching the front end for catching up the needle holder; said plunger has a conical head built on the front end, and said conical head has a circular barb built on the middle portion. The safety syringe provided by the present invention can be withdrew into the inside of the tube, and also suit to match to diversity of standard needles for replacing, it also has simple structure, easy manufacturing and convenient use with high safeness features.
Patent AU-2006269119-B2 (AU)
Title: Actuator with means for determining the position of an activation element
Inventor: SORENSEN RENE
IPC: F16H25/20
Filed: 2006-07-13
Granted: 2012-08-16
Abstract: Actuator comprising of a quick release unit and a means for determining the position of an activation element. With the quick release unit it is possible to release the activation element from the actuator's electric motor and the transmission or, at least part of it, to make a rapid adjustment to the activation element without the motor and transmission. The means typically used for determining the position of the activation element comprises of a potentiometer, an optical or magnetic encoder indirectly driven by the motor. By connecting the instrument for position determination (33) to the spindle (2) or the part of the transmission between the quick release and the spindle (2), the position of the activation element remains known regardless of whether it is released or connected, or has been released.
Patent AU-2006286704-B2 (AU)
Title: Low-fat confectionery product being a water-in-oil emulsion
Inventor: ROUSSET PHILIPPE
IPC: A23L33/20
Filed: 2006-08-31
Granted: 2012-03-15
Abstract: The present invention covers a low-fat confectionery product comprising at most 20% fat phase, at least 60% aqueous phase, cocoa particles, and a structuring agent, the product being a water in oil emulsion. The invention further relates to processes of manufacture of said low fat confectionery product.
Patent AU-2006327567-B2 (AU)
Title: Method of producing a high security film and high security film produced by the said method
Inventor: THANAWALA NIKITA KAMLESH
IPC: B41M3/00
Filed: 2006-12-01
Granted: 2012-12-20
Abstract: The invention relates to a high security film, optionally in the form of a slit thread or a micro tape, which is then inserted into high security paper such as a bank note paper and the like during the paper making process. The invention envisages a novel method of producing such a high security film using a print transfer method, wherein one or more security features are incorporated on one or more indicia including letters, optionally graphics, during such a production process, using multiple printing stations and lamination.
Patent AU-2006343832-B2 (AU)
Title: New benzothiazinone derivatives and their use as antibacterial agents
Inventor: UTE MOLLMANN
IPC: A61P31/04
Filed: 2006-05-24
Granted: 2011-07-21
Abstract: Novel benzothiazin derivatives of formula (I) and their use as antibacterial agents in infectious diseases caused by bacteria, especially tuberculosis (TB) and leprosy caused by mycobacteria, wherein R and Rare, independently each from other, NO, CN, CONRR, COOR, CHO, halogen, NRR, SONRR, SR, OCF, mono-, di or trifluoromethyl; R and R are, independently each from other, H, a saturated or unsaturated, linear or branched aliphatic radical having 1-7 chain members, cycloalkyl having 3-6 carbon atoms, benzyl, SR, OR; R and R are, independently each from other, a saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-8 chain members, cycloalkyl having 3-6 carbon atoms, phenyl, or R and R together represent a bivalent radical -(CR )m-, or R and R together represent bivalent radicals: formula (II) or (III), wherein m is 1-4, or represent bivalent radicals a saturated or unsaturated mono or polyheterocycles with heteroatoms N, S, O and substituted by (R)x, wherein x is 1-4.
Patent AU-2007211854-B2 (AU)
Title: Hybrid process using ion exchange resins in the selective recovery of nickel and cobalt from leaching effluents
Inventor: COSTA RENATO DE SOUZA
IPC: C22B3/24
Filed: 2007-02-02
Granted: 2012-07-12
Abstract: The present invention is directed to a hybrid process using ion ex- change resins in the selective recovery of nickel and cobalt of leaching effluents that is comprised of the steps of processing (1 ) the laterite ore (M), which is then treated through leaching (2) (either atmospheric or under pressure), considering solutions from the solid-liquid separation step of existing plants already in operation (2) as well, in a way that the downstream process comprises an ion exchange hybrid circuit, wherein the first ion exchange step (3) with resins (Re) exhibits specific selectivity conditions for the removal of iron, aluminum and copper and an increased pH, and the second ion exchange step (4) allows the removal of nickel and cobalt.
Patent AU-2007235463-B2 (AU)
Title: Compositions of less immunogenic and long-circulating protein-lipid complexes
Inventor: STRAUBINGER ROBERT M
IPC: A61K9/127
Filed: 2007-03-30
Granted: 2012-11-22
Abstract: Provided are lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.
Patent AU-2007261013-B2 (AU)
Title: Anti-inflammatory dissolvable film
Inventor: SAFFER ARON J
IPC: A61K9/70
Filed: 2007-06-20
Granted: 2013-07-11
Abstract: Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.
Patent AU-2007275572-B2 (AU)
Title: High-current, compact flexible conductors containing high temperature superconducting tapes
Inventor: OTTO ALEXANDER
IPC: H01B12/06
Filed: 2007-07-23
Granted: 2014-03-06
Abstract: High-current, compact, flexible conductors containing high temperature superconducting (HTS) tapes and methods for making the same are described. The HTS tapes are arranged into a stack, a plurality of stacks are arranged to form a superstructure, and the superstructure is twisted about the cable axis to obtain a HTS cable. The HTS cables of the invention can be utilized in numerous applications such as cables employed to generate magnetic fields for degaussing and high current electric power transmission or distribution applications.
Patent AU-2007299162-B2 (AU)
Title: Centrifugal separator
Inventor: THOMAS PISTORIUS
IPC: B07B7/083
Filed: 2007-08-17
Granted: 2011-11-17
Abstract: The invention relates to a centrifugal separator having a feed-line channel (1) for a flow (S) which contains coarse and fine particles, a first discharge channel (2) for a flow which contains predominantly coarse particles, a second discharge channel (3) for a flow which contains predominantly fine particles, and a separator space (4) having at least one separator device, wherein the separator space (4) connects the feed-line channel (1) to the first discharge channel (2) and the second discharge channel (3), and wherein the feed-line channel (1), the separator space (4) and the two discharge channels (2, 3) form a flow path. In order to improve the degree of efficiency, the invention proposes that, as a first separator device (5), one or more collector pockets (6) which protrude into the flow path are arranged in the separator space (4). Furthermore, the invention relates to a corresponding method for separating a flow (S) which contains coarse and fine particles.
Patent AU-2007336564-B2 (AU)
Title: Pharmaceutical compositions capable of inducing apoptosis in tumour cells, useful for diagnosis and treatment of B-Chronic Lymphocytic Leukaemia
Inventor: PEREZ RODRIGUES ROLANDO
IPC: G01N33/574
Filed: 2007-12-24
Granted: 2012-11-01
Abstract: The present invention concerns concerns immunology and in particular the preparation of pharmaceutical compositions which contain a humanized monoclonal antibody which recognizes the leukocyte differentiation antigen CD6. In accordance with the disclosure, the aim of this invention is to provide pharmaceutical compositions containing an anti-CD6 humanized monoclonal antibody for the diagnosis and treatment of Lymphoprofilerative Syndromes in particular B-Chronic Lymphocytic Leukaemia. The field of use of the present invention encompasses oncology.