baber/WOPTO huggingface dataset:
Patent EP-0572489-B1 (EP)
Inventor: SCHOENECKER BRUNO
IPC: C07J51/00
Filed: 1992-02-19
Granted: 1996-09-04
Abstract: Starting compounds for preparing calcitriol (1$g(a), 25-dihydroxycholecalciferol) and its derivatives showing, as compared with calcitriol, some modifications, particularly in the C-17 lateral chain, a method for preparing these starting compounds and intermediate products for this method are described. The new compounds have the general formula (I), wherein R?1 stands for a hydrogen atom, an alkyl, silyl, acyl, aryl, alkoxycarbonyl or alkoxyalkyl group whose meaning is more closely defined in the description and either a) A stands for a methylene group and R the residue -(CH2?)n?-CH2?-CR?2R?3OH (n = 1, 2, 3, 4, 5, 6, 7), wherein R?2 and R?3 stand independently for a hydrogen atom, a C1-4? alkyl group or R?2 and R?3 stand for a cyclopropyl to cyclohexyl ring or b) A stands for a direct bond and R a carbaldehyde residue. The new compounds are prepared from the known compound (20S)-20-hydroxymethyl-1,1-4-pregnadien-3-one by isomerization to the 1,5-dien-3-one and then, in case a) conversion of the 20-hydroxymethyl group to a 20-sulfonyloxymethyl group, reduction of the 3-keto group to the hydroxy group, construction of the side chain, oxidation to the 7-keto compound, epoxidation in the 1,2 position, conversion of the 7-ketone to the corresponding tosylhydrazide and reduction of the 7-tosylhydrazide with lithium aluminium hydride. In case b), the 20-hydroxymethyl group is protected by a protective group which is readily split off, the 5,7-diene is prepared as in a), the protective group is split off and the 20-hydroxymethyl compound is oxidized to the corresponding aldehyde.
Patent EP-0584186-B1 (EP)
Title: Receptor ligands
Inventor: NORINDER ULF
IPC: A61P9/06
Filed: 1992-05-12
Granted: 1996-08-21
Abstract: PCT No. PCT/SE92/00307 Sec. 371 Date Feb. 25, 1994 Sec. 102(e) Date Feb. 25, 1994 PCT Filed May 12, 1992 PCT Pub. No. WO92/20331 PCT Pub. Date Nov. 26, 1992Use of a compound selected from the group consisting of 3,5-diiodo-4-(2-N, N-diethylaminoethoxy)phenyl-(2-butylbenzofur-3-yl)methanol hydrochloride (001), 2-methyl-3-(3,5-diiodo-4-(2-N,N-diethylaminoethoxy)-benzoyl)benzofuran hydrochloride (003), 2-n-butyl-3-(3,5-diiodo-4-carboxymethoxybenzoyl)benzofuran (005), 2-methyl-3-(3,5-diiodo-4-hydroxy-benzoyl)benzofuran (011), 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (015), 4'-hydroxy-3'-iodo-3,5-diiodo-4-(2-N,N-diethylaminoethoxy)benzophenon hydrochloride (024), 2-butyl-3-(3-iodo-4-hydroxy-benzoyl)benzofuran (029), 4'4'-dihydroxy-3'3,5-triiododiphenylmethan (032), which compound is a 3,5,3'-triiodothyronine (T-3) receptor ligand, for the preparation of a medicament for the therapeutic or prophylactic treatment of a disorder which depends on the expression of T-3 regulated genes, and pharmaceutical preparations comprising said compounds, are disclosed. Further, a method of prophylactically or therapeutically treating a patient having a disorder which depends on the expression of 3,5,3''-triiodo-thyronine (T-3) regulated genes is also disclosed. The invention additionally comprises product protection for all the above listed compounds, except the compound (011).
Patent EP-0587719-B1 (EP)
Inventor: EYRE DAVID R
IPC: C07K16/00
Filed: 1992-05-15
Granted: 1998-10-28
Abstract: The invention provides an immunological binding partner which binds to wherein J is pyroglutamic acid or glutamine, and (Leu) is optional leucine; which immunological binding partner is not monoclonal antibody 1H11.
Patent EP-0610284-B1 (EP)
Inventor: HICKSON MALCOLM HEDLEY
IPC: E04F19/08
Filed: 1992-10-19
Granted: 1997-04-16
Abstract: A pipework (or cabling) duct is formed in a floor from channel members having a generally rectangular U-shape section with inwardly directed flanges (50) on the opposed walls to support a lid. Flooring of the type having a solid base, rigid insulating material on the base and board as a surface layer is then cut to remove the surface layer and insulation in the pattern required, the channel members are located in the cut-outs and attached to the surface layer boarding and, after installation of the pipework or cabling, the lid (53) is fitted. This can be formed from the cut out portions of the surface layer, but is preferably an inverted channel-shaped extrusion.
Patent EP-0610436-B1 (EP)
Inventor: SIMMONDS PETER
IPC: C07K16/00
Filed: 1992-11-20
Granted: 2003-01-22
Abstract: New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more complete screening of blood samples for HCV, and allow HCV genotyping.
Patent EP-0565903-B1 (EP)
Inventor: AUERBACH BERNHARD
IPC: G01N33/68
Filed: 1993-03-19
Granted: 1998-02-11
Abstract: The invention relates to an improved diagnostic method for the immunological determination of one or more analytes by means of specific binding partners, where one specific binding partner is immobilised on a carrier and the extent of the binding of the analyte to the first specific binding partner is determined by means of a second binding partner which is specific for the analyte and is labelled either directly or via other binding partners.
Patent EP-0576886-B1 (EP)
Inventor: ROTHHARDT MANFRED
IPC: G01B9/02
Filed: 1993-06-09
Granted: 1997-04-16
Abstract: In a laser interferometric measurement system for a plurality of measuring stations, in which each measuring station is assigned an interferometer (22, 26, 27), and which is preferably used as a multiple-measuring or multi-coordinate measuring device for the purpose of measuring lengths, according to the invention an interferometer (22) of at least one measuring station has a pair of reference reflectors (24, 25) having a fixed, defined spacing relative to one another. In each interferometer (22, 26, 27), beams which are incident as mutually equal pairs and whose frequencies differ from one another have source locations for generating component beams which are assigned to one another in conjunction with a direction of propagation which is the same at least in sections, and of which, each component beam of the one frequency has, after it has traversed an interferometer arm, a common beam path with the assigned component beam of the other frequency so as to produce interference. All the interference signals are measured and evaluated simultaneously. The invention can be used to construct a measurement system having a plurality of stations from compact interferometers with comparatively small dimensions, in which the interference (noise) quantities, such as change in the refractive index of the measurement medium and frequency fluctuations in the laser light source, have as little effect as possible on the measurement result obtained. <IMAGE>
Patent EP-0611326-B1 (EP)
Inventor: PERRIER ERIC
IPC: A23L1/00
Filed: 1992-10-27
Granted: 1997-08-06
Abstract: A method for producing nanocapsules with cross-linked protein-based walls, comprising preparing emulsions of said proteins and crosslinking these with a crosslinking agent having reactive groups which react with the reactive groups of said proteins, particularly acylatable groups, to cause an interfaced crosslinking reaction between the proteins and the crosslinking agent, and thereby form capsules with walls based on the proteins crosslinked by the crosslinking agent. A fine emulsion of said proteins is prepared by adjusting the surface tension of the various liquid phases. Biocompatible and biodegradable nanocapsules having improved controlled release are thereby obtained.
Patent EP-0603406-B1 (EP)
Inventor: SAITO SHUJI
IPC: C12N15/31
Filed: 1993-05-28
Granted: 2001-09-19
Abstract: A highly efficacious vaccine for infectious diseases caused by fowl Mycoplasma gallisepticum, prepared by utilizing a substantially pure protein which has a molecular weight of about 40 kDa, is coded for by a DNA sequence originating in Mycoplasma gallisepticum and having a specified restriction enzyme cleavage map, and can act on mycoplasma-immune or mycoplasma-infected serum, or other protein having equivalent functions.
Patent EP-0647110-B1 (EP)
Inventor: ARTEMI PAUL
IPC: A47G25/14
Filed: 1993-07-01
Granted: 1997-02-26
Abstract: Le dispositif porte-cintres de l'invention se compose de deux parties: une partie crochet de préférence rigide en matière plastique ou en métal destinée à être accrochée à un rail, et une boucle ou une sangle flexibles ou une série de boucles conçues pour recevoir plusieurs cintres. Les deux parties sont reliées de manière flexible et la longueur de la boucle par rapport au rail peut être réglée. Ce dispositif permet de suspendre un plus grand nombre de vêtements à un seul rail que sur les dispositifs existants, et est particulièrement utile pour le transport et le stockage de vêtements en magasin, en entrepôt ou en usine. Deux dispositifs peuvent être accouplés et transportés sur les épaules d'un utilisateur.
Patent EP-0651619-B1 (EP)
Inventor: FOSTER L DALE
IPC: A61G7/10
Filed: 1993-07-12
Granted: 1999-09-15
Abstract: A hospital bed supported on a wheeled base, and a ventilator supported on a wheeled cart and docked to the base of the bed, the combination of ventilator and bed capable of being rolled as a single unit. The ventilator cart includes a wheeled base, and supports connected to the base for supporting a ventilator, with the supports providing for selective raising and lowering of the ventilator. The hospital bed base is wheeled and has a generally Y-shaped base frame. The outspread arms of the Y-shaped base frame receive the ventilator cart so that the two may be docked together. The ventilator when docked to the hospital bed base falls within the footprint of the bed as projected downwardly onto the floor. A latch secures the ventilator to the bed base. A disabling switch disables the high/low function of the bed preventing the bed from being lowered downwardly onto the ventilator. A power supply mounted to the bed base provides for uninterrupted operation of the ventilator. A care cart docks to the foot end of the bed and within the bed's footprint and supplies DC electricity, oxygen and air to the ventilator when the ventilator is docked to the head end of the bed. The care cart has a wheeled base, a battery housing on the base, a structure for connecting the cart to the bed base. A motorized dolley is incorporated into another embodiment of the care cart to provide motorized transport of ventilator, bed and cart.
Patent EP-0658104-B1 (EP)
Inventor: DEMMER FRITZ
IPC: A61K9/20
Filed: 1993-08-19
Granted: 1996-10-23
Abstract: PCT No. PCT/EP93/02218 Sec. 371 Date Mar. 1, 1995 Sec. 102(e) Date Mar. 1, 1995 PCT Filed Aug. 19, 1993 PCT Pub. No. WO94/05949 PCT Pub. Date Mar. 17, 1994Elongated, divisible tablet especially for pharmaceutical applications which, when the underside of the tablet is rested on a flat support, touches the support with two zones protruding from both ends of the underside of the tablet but not with the intervening zone wherein the protruding zones are formed as bulges. Such a tablet can be easily divided into two halves with one hand and picked up from a support. In addition it is easily manufactured.
Patent EP-0624833-B1 (EP)
Inventor: SEKI MASAKI
IPC: G05B19/4103
Filed: 1993-10-01
Granted: 1997-12-10
Abstract: L'invention concerne un appareil à commande numérique conçu pour se déplacer parallèlement ou perpendiculairement à une forme donnée pour produire facilement un prototype simple au moyen d'une machine outil universelle. Un dispositif de stockage graphique (1) est conçu pour afficher des informations de guidage sur une unité d'affichage (16), par l'intermédiarie d'un circuit de commande graphique (15). Ledit dispositif de stockage graphique (1) stocke des formes linéaires et arquées données qui ont été introduites de façon interactive, par un opérateur, au moyen d'un clavier (17). Lorsqu'un dispositif d'interpolation (2) a détecté un signal d'impulsion HP émis par un générateur d'impulsions manuelles (41), il lie un signal de commutation H/V qui est émis par un dispositif de commutation et qui commande soit un mouvement parallèle  soit un mouvement perpendiculaire. Le dispositif d'interpolation (2) émet ensuite une impulsion d'interpolation CP correspondant au signal d'impulsion HP et au signal de commutation H/V, conformément à la forme donnée stockée dans le dispositif de stockage graphique (1), puis il envoie cette impulsion CP à un circuit de commande axiale (18).
Patent EP-0667943-B1 (EP)
Inventor: MCNAUGHTON JAMES
IPC: F16L37/098
Filed: 1993-10-04
Granted: 1999-08-04
Abstract: Two unique quick connect fluid coupling embodiments have a tube inner end which does not contact a seal if the tube is not fully connected. Preferably, a retainer retains the tube within the bore. The retainer is of the avalanche type such that a high force is required to insert the tube, and once this high force is overcome the momentum of the tube carries it to its fully inserted position. No seal is formed between the tube and seals within the housing unless the tube has moved beyond the avalanche point where the high force begins. Once the tube has moved beyond that point, it will be fully connected. The invention ensures that there would be no seal between a tube and a housing unless the tube is fully connected.
Patent EP-0666856-B1 (EP)
Inventor: HARRISON TIMOTHY
IPC: A61P37/00
Filed: 1993-10-27
Granted: 2000-01-05
Abstract: PCT No. PCT/GB93/02214 Sec. 371 Date Apr. 13, 1995 Sec. 102(e) Date Apr. 13, 1995 PCT Filed Oct. 27, 1993 PCT Pub. No. WO94/10165 PCT Pub. Date May 11, 1994The present invention is directed to compounds of the formula (I)   <IMAGE>   wherein R1, R2, R3, R4, R5, R6, and R7 are defined herein, and pharmaceutically acceptable salts thereof, which are useful as tachykinin antagonists,
Patent EP-0621263-B1 (EP)
Inventor: AKAZAWA MITSUJI
IPC: A61P25/04
Filed: 1994-04-21
Granted: 2000-07-19
Abstract: An external anti-inflammatory and analgesic plaster preparation includes as an active ingredient a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid, with a cyclic organic having the general formula (I): <CHEM> wherein X is a group of the formula -(CH2)m- in which m is an integer of 0 or 1 and n is an integer of 2 and a pH value of the preparation is adjusted to a range of 7.3 to 9.0.
Patent EP-0629477-B1 (EP)
Inventor: BONNEVIER ROINE
IPC: B28B3/06
Filed: 1994-06-13
Granted: 1997-09-03
Abstract: A filter arrangement for a machine for manufacturing concrete slabs, said machine comprising a plurality of mould frames (4); lower and upper press plates (6, 17) which cooperate with the mould frames (4) to form mould cavities (9) for concrete compound that contains a surplus of water; and channel systems (20, 21, 22, 23) connecting the mould cavities (9) to a vacuum source for evacuation of said excess, said filter arrangement including a filter cloth (25) of a plastic material for abutment against the side of a press plate (6, 17) facing the mould cavity (9). According to the invention the filter arrangement also includes a frame (26) of a flexible plastic material for sealing cooperation with the mould frame and having a rear portion (27) forming an attachment means for cooperation with an attachment means (35) of the press plate (6, 17) for attachment of the filter arrangement to the press plate. <IMAGE>
Patent EP-0687877-B1 (EP)
Inventor: VROOME CLEMENS JOHANNES M DE
IPC: F26B13/00
Filed: 1994-06-15
Granted: 1998-02-04
Abstract: In a method for preventing the occurrence of an explosive state in a gas mixture, especially of solvents in air, in an essentially confined space, virtually complete oxidation of at least part of the gas mixture taking place, either the temperature difference  DELTA T between the temperatures of the gas mixture before and after the oxidation is determined, and if the temperature difference  DELTA T is greater than a maximal permissible temperature increase  DELTA Tmax, safety measures are taken, or the temperature T1 of the gas mixture before the oxidation and the temperature T2 of the gas mixture after the oxidation are measured, and the measured temperatures T1 and T2 are compared with a minimum temperature Tmin before oxidation of the gas mixture and a maximum temperature Tmax after oxidation of the gas mixture, the difference between Tmax and Tmin being less than, or equal to, the maximal permissible temperature increase  DELTA Tmax, and if the measured temperatures T1 and T2 are outside the interval determined by the maximum and minimum temperatures Tmax and Tmin, safety measures are taken. In addition, the use of this method in drying webs printed with ink, and an appliance for this purpose are described. <IMAGE>
Patent EP-0669045-B1 (EP)
Inventor: ASKOV GRENAAE THORSTEN
IPC: H01R31/06
Filed: 1993-11-12
Granted: 1997-01-15
Abstract: A multiwire shielded cable (14) for a data network is for example pre-installed in the wall (45) of a building. The end of the cable (14) enters a housing part (66) and is coupled to a Western connector (10) or another connector having a similar design, whatever the connector system that will be later used. When the user-specific equipment is later installed, a modular housing (29) is inserted into the housing part (66). The modular housing (29) has an input tip jack compatible with the connector (10) and another tip jack on the side of the user which may be a jack of the Western type, an IBM data jack or a BNC jack (27). The connector (10) is provided with a metallic shield which directly contacts the shielding of the cable (14) and the metallic shield of the input tip jack, which in turn is electrically connected to the metallic modular housing (29). An easily adaptable data installation system is thus obtained, in which the area from the end of the cable to the user-specific tip jack (27) is very effectively protected against perturbing radiation.
Patent EP-0666889-B1 (EP)
Inventor: HOFFMANN HANS-GUNTER
IPC: C09J7/20
Filed: 1993-10-29
Granted: 1998-09-16
Abstract: Afin de protéger et cacher les joints d'étanchéité en caoutchouc utilisés pour monter des pare-brise de véhicules lorsqu'on repeint les carrosseries de véhicules on pousse un ruban adhésif suffisamment résistant dans un espace formé par la lèvre du joint d'étanchéité en caoutchouc qui s'étend à une certaine distance du pare-brise et de la carrosserie du véhicule. On plie ensuite le ruban adhésif de protection et la lèvre sur le pare-brise et on le fait adhérer sur le pare-brise en utilisant pour cela la couche située sur la face auto-adhésive.
Patent EP-0695376-B1 (EP)
Inventor: DOEHLER JOACHIM
IPC: H01L31/04
Filed: 1994-02-14
Granted: 2000-04-19
Abstract: On décrit une porte gazeuse améliorée (42) qui relie des régions où règnent des compositions et/ou des pressions de gaz différentes. Cette porte gazeuse comporte un passage allongé étroit (92) prévu pour laisser passer un matériau de substrat (11) entre lesdites régions, et un dispositif d'introduction (93) permettant d'introduire un flux de gaz de balayage non contaminant dans une partie centrale de ce passage. Cette porte gazeuse se caractérise par la hauteur du passage et le débit du gaz de balayage dans ce passage qui donnent lieu à un flux transsonique du gaz de balayage entre le dispositif d'introduction et au moins une des deux régions reliées, ce qui permet d'isoler effectivement une région, caractérisée par une composition et pression de gaz données, d'une autre région caractérisée par une composition et une pression de gaz différentes, en diminuant la longueur de trajet libre moyen entre des collisions d'espèces qui diffusent dans la région du flux transsonique. Cette porte gazeuse comporte de préférence un collecteur placé au point de jonction où le dispositif d'introduction de gaz et le passage se raccordent.
Patent EP-0685144-B1 (EP)
Inventor: BOWMAN LYN
IPC: H01L23/34
Filed: 1994-02-02
Granted: 2000-04-12
Abstract: A microminiature Stirling cycle engine or cooler is formed utilizing semiconductor, planar processing techniques. Such a Stirling cycle thermomechanical transducer has silicon end plates and an intermediate regenerator. The end plates are formed with diaphragms and backspaces, one end plate forming the expansion end and the opposite end plate forming the compression end, with the regenerator bonded in between. A control circuit apparatus is linked to the diaphragms for controlling the amplitude, phase and frequency of their deflections. The control circuit apparatus is adapted to operate the transducer above 500 Hz and the passages and the workspace, including those within the regenerator, expansion space and compression space, are sufficiently narrow to provide a characteristic Wolmersley number, which is characteristic of the irreversibilities generated by the oscillating flow of the working fluid in the workspace, below substantially 5 at the operating frequency above 500 Hz. Additionally, the amplitude of the vibrations of the diaphragm vibrations are sufficiently small to provide the working fluid a maximum Mach number below substantially 0.1 at an operating frequency above 500 Hz.
Patent EP-0690854-B1 (EP)
Inventor: REITZ DAVID B
IPC: C07D233/70
Filed: 1994-03-08
Granted: 2000-07-12
Abstract: A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula <CHEM> wherein each of R<1>, R<2> and R<3> is independently selected from hydrogen, alkyl, alkoxy, cyano, halo, hydroxy, nitro, amino, alkylamino,carboxyl, alkoxycarbonyl, formyl, alkylcarbonyl and haloalkylcarbonyl; with the proviso that at least one of R<1>, R<2> and R<3> must be a substituent other than hydrogen, and with the further proviso that when each of R<1> and R<3> is hydrogen, then R<2> cannot be chloro; wherein R<4> is selected from hydrogen, alkyl, halo, haloalkyl, formyl, carboxyl and alkoxyalkyl; wherein R<5> is selected from alkyl, phenyl, phenylalkyl, cycloalkyl and cycloalkylalkyl; and wherein R<6> is an acidic group selected from COOH and <CHEM> or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
Patent EP-0695478-B1 (EP)
Inventor: SAUER DONALD JON
IPC: H03B5/20
Filed: 1994-04-19
Granted: 1997-08-20
Abstract: Un détecteur de phase d'un circuit à boucle à verrouillage de phase mesure une erreur de phase entre un signal de sortie d'un oscillateur et un signal de synchronisation. Lorsqu'une différence entre l'erreur de phase mesurée dans une paire de périodes de lignes horizontales dépasse une première valeur, laquelle indique l'incohérence d'erreur de phase, la phase du signal de sortie de l'oscillateur n'est pas corrigée et le circuit à boucle à verrouillage de phase fonctionne en mode de repos.
Patent EP-0712387-B1 (EP)
Inventor: HAADSMA-SVENSSON SUSANNE R
IPC: C07C323/30
Filed: 1994-07-21
Granted: 1999-12-08
Abstract: PCT No. PCT/US94/08046 Sec. 371 Date May 14, 1996 Sec. 102(e) Date May 14, 1996 PCT Filed Jul. 21, 1994 PCT Pub. No. WO95/04713 PCT Pub. Date Feb. 16, 1995Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I:   <IMAGE>   wherein R1 and R2 are independently chosen from hydrogen, C1-C8 alkyl, OCH3, OH, OSO2CF3, OSO2CH3, SOR5, CO2R5, CONH2, CONR5R6, COR5, CN, SO2NH2, SO2NR5R6, SO2R5, -OCO-(C1-C6 alkyl), -NCO-(C1-C6 alkyl), -CH2O-(C1-C6 alkyl), -CH2OH, -CO-Aryl, -NHSO2-Aryl, -NHSO2-(C1-C6 alkyl), phthalimide, thiophenyl, pyrrol, pyrrolinyl, oxazolyl, or R1 and R2 together form -O(CH2)1-2O- or -(CH2)3-6- (except that only one of R1 and R2 can be hydrogen or OH in any such compound); R3 and R4 are independently chosen from C2-C4 alkenyl, C3-C8 alkynyl, C3-C8 cycloalkyl, -(CH2)p- thienyl (where p is 1-4), or C1-C8 alkyl (except where R1 or R2 are hydrogen or OH or where both R1 and R2 are OCH3 or a C1-C8 alkyl); R5 is hydrogen, C1-C8 alkyl, C2-C4 alkenyl, C3-C8 cycloalkyl; and R6 is C1-C8 alkyl, C2-C4 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, or Aryl.