Patent SG-11201810627U-A (SG)
Title: Compositions and methods for the treatment of human papillomavirus (hpv)-associated diseases
Inventor: JONES FRANK
IPC: C12N15/37
Filed: 2017-06-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 December 2017 (07.12.2017) WIPO I PCT Iiiimmomiolollmolommoololoiolloiloomilioluovoiml (10) International Publication Number WO 2017/210649 Al (51) International Patent Classification: A61P 31/18 (2006.01) C12N 15/12 (2006.01) C07K 14/16 (2006.01) C12N 15/33 (2006.01) C07K 14/025 (2006.01) C12N 15/37 (2006.01) (21) International Application Number: PCT/US2017/035841 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/345,592 03 June 2016 (03.06.2016) US (71) Applicant: ETUBICS CORPORATION [US/US]; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). (72) Inventors; and (71) Applicants: JONES, Frank, R. [US/US]; 410 West Harri- son Street, Suite 200, Seattle, WA 98119 (US). BALINT, Joseph [US/US]; 410 West Harrison Street, Suite 200, Seat- tle, WA 98119 (US). LATCHMAN, Yvette [US/US]; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). RICE, Adrian [US/US]; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). GABITZSCH, Elizabeth [US/US]; 410 West Harrison Street, Suite 200, Seattle, WA 98119 (US). (74) Agent: RAMANATHAN, Renuka et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — (54) Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED DISEASES 100 5 0 - co 2 O. - 0 - Ad5 [E1-E2b-]-null Ad5 [E1-E2b+ES/E7 0© 0 0 10 20 30 40 Days post tumor implantation FIG. 2B (57) : Methods and compositions for constructing and producing recombinant adenovirus- based vector vaccines are provided. In particular aspects, there are be provided compositions and methods involving adenovirus vectors comprising genes for target antigens, such as novel antigens of HPV E6 and/or HPV E7 for use in treatment methods that generate highly reactive anti-HPV and anti-tumor immune responses in subjects with preexisting immunity to adenovirus. [Continued on next page] W O 20 17 / 2106 49 Al WO 2017/210649 Al MIDEDIMOMMIDIROMEHIDEIONINHCHINVOIMIE Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))