baber/WOPTO huggingface dataset:
Patent CR-20220591-A (CR)
Title: Compositions and methods for delivering pharmaceutically active agents
Inventor: CHRISTIE RONALD JAMES
IPC: C07K7/64
Filed: 2021-04-28
Abstract: The invention relates to modified lysines of the formula (I). The invention further relates to polypeptides comprising one or more modified lysine residues, pharmaceutical delivery systems comprising these polypeptides, pharmaceutical compositions containing them, and to their use in therapy.
Patent EC-SP003341-A (EC)
Title: Metodos para tratar metales utilizando silanos de ureido y silanos multi-sililo-funcionales en mezclas
Inventor: BROWN KEVIN
IPC: B05D7/24
Filed: 2000-02-04
Abstract: La presente invención se refiere a un método de tratamiento de metales, en particular de un método de tratamiento de metales, a fin de mejorar la resistencia a la corrosión. El método comprende la aplicación de una solución que contenga una o más ureido silanes en mezcla con uno o más silyl-multi-funcional; silanes a un sustrato de metal. El método es especialmente adecuado para su uso en laminados en frío de acero, zinc, hierro, aluminio y aleación de aluminio superficies.
Patent EC-SP034436-A (EC)
Title: Sales de valsartan
Inventor: MARTI ERWIN
IPC: A61P43/00
Filed: 2003-01-17
Abstract: La invención se refiere a nuevas sales de valsartan, o sales cristalinas y también parcialmente cristalinas y amorfas de valsartan, a la producción y usos respectivos, y a preparaciones farmacéuticas que contienen dicha sal.
Patent EC-SP034518-A (EC)
Title: Nuevos retinoides para el tratamiento de enfisema
Inventor: SJOGREN ERIC BRIAN
IPC: A61K31/381
Filed: 2003-03-18
Abstract: La presente invención proporciona nuevos compuestos retinoides y métodos para su síntesis, el uso de tales compuestos para la preparación de medicamentos para el tratamiento o prevención de efisema, cáncer y trastornos dermatológicos, métodos para tales enfermedades y composiciones farmacéuticas adecuadas para el tratamiento o prevención de enfisema, cáncer y trastornos dermatológicas.
Patent EC-SP055808-A (EC)
Title: Nuevos compuestos quimicos
Inventor: HASEGAWA MASAICHI
IPC: C07D277/20
Filed: 2005-05-20
Abstract: Esta invención se refiere a compuestos identificados recientemente para inhibir proteínas hYAK3 y a procedimientos para tratar enfermedades relacionadas con el desequilibrio o la actividad inapropiada de las proteínas hYAK3.
Patent EC-SP074704-A (EC)
Title: Combinaciones de inhibidor(es) de la absorción de esterol con modificador(es) sanguíneos para tratar cuadros vasculares
Inventor: KOSOGLOU TEDDY
IPC: A61K45/06
Filed: 2007-12-07
Abstract: La presente invención proporciona composiciones, combinaciones terapéuticas y métodos que incluyen: a) al menos un inhibidor de la absorción de esterol; y b) al menos un modificador sanguíneo, el cual puede ser útil para tratar cuadros vasculares y para reducir los niveles plasmáticos de esteroles.
Patent EC-SP088105-A (EC)
Title: Derivados de n-(arilalquil)-1h-pirrolopiridin-2-carboxamidas, su preparación y su aplicación en terapéutica
Inventor: DUBOIS LAURENT
IPC: A61K31/437
Filed: 2008-01-14
Abstract: La invención se refiere a los compuestos de fórmula general (I) : en la que n es igual a 0, 1 , 2 ó 3 ; el núcleo pirrolopiridina es un grupo pirrolo[3,2-b]piridina, un grupo pirrolo[3,2-c]piridina, un grupo pirrolo[2,3-c]piridina o un grupo pirrolo[2,3-b]piridina; estando el núcleo pirrolopiridina opcionalmente sustituido en posición carbonada 4, 5, 6 y/o 7 con uno o varios sustituyentes X, idénticos o difernetes uno del otro ; Z1, Z2, Z3, Z4 y Z5 representan, independientemente uno del otro, un átomo de hidrógeno o de halógeno o un grupo alquilo-C1-C6, cicloalquilo-C3-C7, cicloalquilo-C3-C7-alquileno-C1-C3, fluoroalquilo-C1-C6, alcoxilo-C1-C6, fluoroalcoxilo-C1-C6, ciano, C(O)NR1R2, nitro, NR1R2, tioalquilo-C1-C6, -S(O)-alquilo-C1-C6, - S(O)2-alquilo-C1-C6, SO2NR1R2, NR3COR4, NR3SO2R5 , arilo-alquileno-C1-C6 o arilo, estando el arilo y arilo-alquileno-C1-C6 opcionalmente sustituidos; W representa un grupo bicíclico fusionado de fórmula : unido al átomo de nitrógeno por las posiciones 1, 2, 3 ó 4 ; A representa un heterociclo opcionalmente sustituido de 5 a 7 eslabones que comprende de uno a tres heteroátomos elegidos entre O, S o N ; en el estado de base o de sal de adición a un ácido, así como en el estado de hidrato o de solvato. Procedimiento de preparación y aplicación en terapéutica.
Patent EC-SP099550-A (EC)
Title: Nuevo procedimiento de síntesis de la agomelatina
Inventor: BONTEMPELLI PASCAL
IPC: A61K31/44
Filed: 2009-07-31
Abstract: Procedimiento de síntesis industrial del compuesto de fórmula (I):
Patent EC-SP930907-A (EC)
Title: Macrodol
Inventor: ZAMBRANO MONCAYO HERNAN
IPC: A01N43/76
Filed: 1993-02-11
Abstract: El invento se refiere en la de desinfectar el agua, liberándola de bacterias y hongos, tanto que su toxicidad es nula, por que las concentraciones de los principios activos se encuentran por debajo de los máximos tolerados según regulaciones del INEN para el agua potable. En conclusión no afecta a la salud humana ni animal, al contrario es beneficioso.
Patent FI-20001522-A (FI)
Inventor: MUUTTONEN TIMO
IPC: B28D1/26
Filed: 2000-06-27
Abstract: A rock drill includes a string of components interconnected by screw threads and connected to a shank. A percussion piston is reciprocated against the shank during a drilling operation, while a support device applies axial support to the rear of the shank, to enhance the drilling action. When the components are being unscrewed, the percussion piston is actuated to strike the rear end of the drill string, after the support device has at least partially released the axial support of the shank, to enable tensile stress to be generated in the components by the percussive impacts to facilitate unscrewing of the components.
Patent FI-20106045-A (FI)
Inventor: OTSAMO KATRIINA
IPC: A61B5/11
Filed: 2010-10-11
Abstract: A method and device arrangement are for indicating a state of overstress in a nervous muscular system. An interference current, the frequency and current strength of which can be adjusted, is fed into a part of the nervous muscular system. Those adjustment values of the interference current are stored, which cause one of a set of predetermined physical sensations in the examined part of the nervous muscular system. A measurement-specific average of the strength of the interference current is calculated for each predetermined physical response or sensation in the examined part of the examined nervous muscular system. The measurement-specific average of the interference current for each physical sensation is normalised and a state of overstress of the nervous muscular system is indicated, if the measurement-specific normalised average of the interference current of the physical sensation does not fulfil a set statistical criteria.
Patent FR-1588287-A (FR)
IPC: C08F8/44
Filed: 1968-10-01
Granted: 1970-04-10
Abstract: Crystalline, sequence-type, propylene-styrene copolymers containing quaternary ammonium residues are useful for making anion-exchange membranes.
Patent FR-1601278-A (FR)
Title: Wood fibre panels
IPC: B27N3/10
Filed: 1968-12-23
Granted: 1970-08-10
Abstract: Fibre mass containing just enough residual moisture to ensure flexibility is extruded under pressure through a circular nozzle into a hollow cylindrical shape, which is split along a generatrix and opened out on a plane surface. The strip obtained is cut into pieces which are passed into a heated plate press. Fibre agglomeration is obtained by lignins, without any addition of resin. The strip is dried, downstream of the extruders to obviate use of a support grid and to obtain a smooth faced panel.
Patent FR-1601578-A (FR)
Title: Monovalent metal cellulose acylate - sulphates stabilise
IPC: C08B3/22
Filed: 1968-12-20
Granted: 1970-08-31
Abstract: Stabilisation of monovalent metal cellulose acylate sulphates. B2B. By neutralising the residual acidity, until at least half is neutralised, by treatment in an atmosphere containing at least 25 vol. % of a gaseous amine or mixture of amines. Treatment is effected at 21 degrees-66C for at least 1 sec. Suitable amines have b.p. 121 degrees C and include NH3 or an alkyl, aryl or cycloalkylamine or mixture e.g. ethylamine, methylamine, cyclopropylamine, pyrrolidine etc. The gaseous amine or mixture is admitted into an evacuated chamber at max. pressure 100 mm Hg and containing the cellulose ester material until the pressure reaches atmospheric and heating the material for from 5 mins. to 10 hrs. The monovalent metal cellulose acylate sulphate material is preferably dried in the evacuated chamber at 21 degrees - 66 degrees C before the gaseous amine (or mixture) is admitted.
Patent GB-1053602-A (GB)
IPC: F01B3/10
Abstract: 1,053,602. Reciprocating pumps and motors. H. THOMA. Aug. 14, 1963 [Aug. 23, 1962], No.32140/63. Heading F1A. The rotary cylinder block 1 of a hydraulic pump or motor is forced against a stationary valve block 30 by a hydraulic device 11 situated in the valve block and acting through a shaft 8. The shaft 8 passes with clearance through a bore in the block 1 and acts thereon through a spherical bearing 10 which permits slight tilting of the block for self-aligning purposes. Pressure fluid is transmitted to the hydraulic piston 11 from the pump discharge passages D1 or D2 through passages 22 containing non-return valves. The lower end of shaft 8 is received in a bearing 9 in the drive shaft for the block 1 and thrust plate 3. In a modification, Fig. 4 (not shown) the shaft 8 is formed integral with the drive shaft and drives the block through gearing 40, 41, and the hydraulic means comprises a plurality of pistons 11 acting on a plate 14 on the end of the shaft. In a modification of Fig. 1, the piston 11 is stepped to provide several annular pressure responsive surfaces and the drive shaft is connected to shaft 8 through a universal coupling.
Patent GB-1143713-A (GB)
IPC: A61K8/44
Abstract: 1,143,713. Hair restorer from foetal skin. L'OREAL. 14 Feb., 1967 [14 Feb., 1966], No. 7062/67. Heading A5B. Compositions for application to the scalp to combat baldness comprise an aqueous extract of skin taken from bovine foetuses weighing 0.8 to 2 kgs. and/or ovine foetuses weighing 500 to 900 gs, together with a topically suitable carrier or excipient. The said weights represent gestation periods of 110-150 days for the bovine foetus and of 75-100 days for the ovine foetus. The compositions may take the form of solutions, lotions, creams or gels, and may also contain cosmetic adjuvants such as dyes, perfumes anti-seborrheic agents, anti-scurf agents, and other substances to combat hair loss; e.g. cysteine-HCl, dl-methionine-HCl, or the substance LB23, a product according to Spec. No. 1,103,738 containing bovine amnotic liquid extracted before 40% of the total gestation period has elapsed. Suitable carriers are cellulose ether aqueous gel, water or aqueous ethanol. The active agent is prepared by removal of the skin of the foetus taken from the uterus immediately after slaughter, with aseptic precautions, followed by chilling to 0‹-4‹C and homogenisation in sterile distilled water. The latter preferably contains a bactericide such as merthiolate; a reducing agent, (cysteine) and a complexing agent, (trisodium citrate). The aqueous suspension is clarified by centrifuging or filtration, the residue washed with water and the washings and filtrate combined; the extract may then be lyophilised. Alternatively the skin may be frozen and ground with solid CO 2  prior to homogenising.
Patent GB-1227554-A (GB)
IPC: B21C47/06
Filed: 1968-06-28
Abstract: 1,227,554. Winding and reeling. SOC. NOUVELLE SPIDEM. 28 June, 1968 [29 June, 1967], No. 31132/68. Heading B3E. [Also in Division B8] Apparatus for winding a sheet or strip 4 into a coil on a cylindrical mandrel 9 is characterized in that a housing having a cylindrical inner surface is disposed concentrically and coaxially with the mandrel, the said housing being divided into two equal parts 1, 2 pivoted together at 5 to enable the parts to be moved through an angle sufficient to enable the completed coil to be readily extracted from the housing and the apparatus further including fluid pressure means for continuously applying the sheet or strip against the mandrel during the initial stages of the winding. The cavity between the mandrel and the housing is closed in fluid-tight manner at its ends 14 and 15 and fluid pressure is supplied to the cavity through a duct 7 attached to part 1 of the housing and peripheral apertures 13 in the housing walls. In operation the end of the sheet is introduced through the gap 3 in the housing and the mandrel rotated by an electric motor. Jets of fluid pressure hold the sheet to the mandrel until sufficient layers have been formed to ensure adhesion. A roller may be provided to strengthen the force of application to the mandrel. In another embodiment (Fig. 6) the mandrel is mounted on a hollow driven shaft 20 closed at one end and its bore in communication with a source of high vacuum. The outer surface of the mandrel has longitudinal channels 21 communicating with radial orifices 17 and with the bore of the shaft 20. The end of the sheet is held to the mandrel by the atmospheric pressure exerted on the outside face thereof assisted by the suction exerted through the orifices 17. The vacuum is broken as soon as there are sufficient turns on the mandrel.
Patent GB-1238061-A (GB)
IPC: B23B27/14
Filed: 1968-03-13
Abstract: 1,238,061. Cutting tools. WICKMAN WIMET Ltd. 6 March, 1969 [13 March, 1968], No. 12141/69. Heading B3T. A cutting insert has a polygonal, e.g. triangular, body of which at least one face has a continuous marginal land 12 and an inner plateau 13 spaced therefrom by a chip-breaker groove 14, the sides of the plateau being convex, whereby the width of the groove increases from points midway between the corners of the body towards the corners. The groove may vary in depth from deepest points at the corners. Both faces may be so formed.
Patent GB-1239043-A (GB)
IPC: H01L21/265
Filed: 1968-12-17
Abstract: 1,239,043. Semi-conductor devices. HUGHES AIRCRAFT CO. 17 Dec., 1968 [26 Dec., 1967 (2)], No. 59879/68. Heading H1K. A semi-conductor body is doped by depositing a layer of a conductivity type determining impurity on the surface and bombarding with ions of a second material to drive the impurity into the body, the ions also entering the surface of the body so that the driven impurities or the ions convert a region of the body to the opposite conductivity type. The ions may be of a material which is inert in the semi-conductor such as carbon, silicon, helium, neon or krypton. Alternatively the ions may be active and produce the opposite conductivity type region. The excess dopant is removed mechanically or by etching and the body is annealed. The desired region shape may be produced by photo-etching the deposited layer before the ion bombardment The semi-conductor material may be silicon, germanium or gallium arsenide, and indium phosphide is also mentioned. Aluminium, boron, indium and gallium may be used as acceptor dopants and arsenic, phosphorus, antimony and bismuth may be used as donor dopants. A planar transistor may be produced as shown in Figs. 4 and 5 by forming a thick masking layer 8 on the periphery of an N-type silicon body 2 leaving an aperture within which is located a thinner layer 9 of antimony. The wafer is then bombarded with P-type ions using either a broad beam or a narrow beam scanned across the wafer. The antimony is driven into the wafer to form the N-type emitter region 10. Some of the P-type ions penetrate deeper into the wafer to produce a thin base region 12 underlying the emitter region. The P-type ions are also implanted into the annular exposed area between the mask 8 and impurity material layer 9 to form thick base contact regions 12<SP>1</SP>. The excess impurity material 9 is then removed and the wafer is annealed. The mask 8 may be of insulating material such as silicon dioxide or silicon nitride or may be of conductive material e.g. an alloy of gold and antimony, to provide the collector contact in which case the edge is etched back, as at 8<SP>1</SP>, after the formation of the emitter and base regions to prevent it shorting the collector junction. The exposed semiconductor surface is oxidized and base and emitter contacts are provided. A PNP transistor may be similarly produced using a P-type substrate, a layer of P-type impurity, e.g. boron or aluminium, and N-type ions, e.g. of antimony.
Patent GB-1251967-A (GB)
IPC: G04F10/04
Filed: 1968-01-31
Abstract: 1,251,967. A/D and D/A converters. BRITISH BROADCASTING CORP. 31 Jan., 1969 [31 Jan., 1968], No. 5046/68. Heading G4H. To convert an analogue signal to digital form a sawtooth signal is compared with the analogue signal, clock pulses from a main clock 14 (Fig. 1) being accumulated in a multiples counter 15 until coincidence is detected when a vernier clock 16 is enabled delivering pulses of a slightly different frequency, these pulses being accumulated in a units counter 18 until coincidence is detected between pulses of both clocks. The vernier clock may comprise an oscillator delivering a signal sin #t which is phase shifted by 90 degrees in a quadrature network (31, Fig. 3, not shown) the signal from which is fed to a modulating function generator (32), the original signal being fed to a similar generator 30. The trigger signal from the comparator is also fed to the generators 30, 32 to hold their outputs at their value at the time t 0  of the triggering signal so that from modulators (29, 33), signals sin #t cos #t are fed to a subtractor until time t 0 , the signals thereafter being sin #t cos #t 0  and cos #t sin #t 0  respectively to give an output sin #(t - t 0 ). To convert a two digit decimal number to an analogue signal one digit is entered in units store and counter 37 (Fig. 4) the other digit being entered in a multiples store. The multiples counter is set to 9 and counted down at a first frequency, a sawtooth generator being started at equality of the counter and store. When the multiples counter and units store are at the same value the units counter is counted down to zero but at a second frequency slightly different from the first, the sawtooth generator being stopped when the units counter reaches zero and its value sampled at that time to give the analogue output signal.
Patent GB-1252096-A (GB)
IPC: H01H15/00
Filed: 1970-04-16
Abstract: 1,252,096. Mechanical switches. INTERNATIONAL STANDARD ELECTRIC CORP. 16 April, 1970 [24 April, 1969], No. 18200/70. Heading H1N. In a slide switch for mounting on a printed circuit-board 1, the fixed contacts 2, 2a, 2b, Fig. 5 (not shown) are components of board 1 or are held by it and the movable contacts 3 are carried by an insulating slider 4 which is slidably arranged in a slot 6, Figs. 3, 4, 5 (not shown) in board 1 and is, at one end, provided with at least one resilient detent arm 9 which slides along board 1 when the switch is actuated and engages with recesses 11, 11a, Figs. 3, 4, 5, in board 1 in the switching positions. A moulded eyelet 4b is provided for connection to an actuating element. Two or more switches may be mounted, one behind the other, in a common slot in a printed circuit-board by clipping the arms 9 of a following slider into recesses 4a, Fig. 3, in the body of a preceding slider so that movement of one slider moves them all.
Patent GB-1252400-A (GB)
IPC: H01F13/00
Filed: 1968-12-03
Abstract: 1,252,400. Degaussing cathode-ray tube apparatus. TEXAS INSTRUMENTS Inc. 3 Dec., 1968 [8 Dec., 1967], No. 7765/71. Divided out of 1,251,058. Heading H4T. A known degaussing arrangement comprising the series arrangement of a degaussing coil 168 (Fig. 1) and a positive temperature coefficient resistor (P.T.C.) 114 connected across an A.C. supply is characterized in that the P.T.C. resistor exhibits a sharp anomalous increase in resistance with temperature at a predetermined temperature so that the degaussing field is reduced to substantially zero and remains such during continued energization of the apparatus. The P.T.C. resistor may comprise lanthanumdoped barium titanate and have the characteristics shown in Figs. 3 and 4. The apparatus may comprise a colour television receiver employing a shadow-mask tube and the series arrangement of the degaussing coil and P.T.C. resistor may be connected across the secondary winding 154 instead of across the primary winding 152 (Fig. 2, not shown). In the latter case, however, a P.T.C. resistor of different value may be required because of the different secondary voltage. The rectifier 162 (which may be replaced by a voltage doubler arrangement) supplies the normal operating voltage for the receiver the load of which is represented by capacitor 164 and resistor 166.
Patent GB-1252593-A (GB)
IPC: B65G13/12
Filed: 1968-06-28
Abstract: 1,252,593. Conveyers. SIRA INSTITUTE. 25 June, 1969 [28 June, 1968], No. 30970/68. Heading B8A. Tiles 13 may be diverted from a conveyer 11 by a mechanism 10 having pairs of rollers A-D, one roller, the uppermost for example, of each pair being driven, and the lowermost rollers being vertically movable by piston-cylinder units 14 which are controlled by a detector 15. If the detector detects a fault in one of the tiles, the units 14, commencing with the unit of roller pair A, are successively actuated and the tile, engaged by the rollers, is diverted on to a subconveyer (not shown) aligned with the mechanism 10. The detector 15, by incorporating a counter, may be used to cause a batch of tiles to be diverted, the lower rollers of the pairs A-D being maintained in their raised positions, Fig. 4, until the required number of tiles have been diverted. Pairs of rollers E, F are fixed relative to one another. Endless belts may be used in place of the rollers.
Patent GB-1256770-A (GB)
IPC: B23H9/10
Filed: 1969-12-08
Abstract: 1,256,770. Electro-machining apparatus. ROBERT BOSCH G.m.b.H. Dec.8, 1969 [Dec.6, 1968], No.59770/69. Heading C7B. In electrolytic machining of metallic articles using a tool electrode through which electrolyte flows, only those parts of the workpiece which are currently being machined are exposed to the electrolyte, and the parts which have previously been machined are protected against undesired corrosion by mechanical shielding. In the form shown a turbine wheel is enclosed in an annular housing having cut-away portion 5, thus exposing part of the wheel to a tool electrode which effects production of blades 6 on the periphery of the wheel, the wheel being rotated relative to the shielding after each machining operation to expose successive portions of the wheel for machining of adjacent turbine blades. Seals 17 and 18 are provided which are radially inwardly slidable to seal against the edge of the wheel and prevent flow of electrolyte into the shielding. Flow lines 20 and 21 are provided to supply washing and passivating fluids to the housing, e.g. a mixture of steam and oil.
Patent GB-1256819-A (GB)
IPC: C07C15/00
Filed: 1970-03-26
Abstract: 1,256,819. Detergent composition. COMPAGNIE ERANCAISE DE RAFFINAGE. ,26 March, 1970 [26 March, 1969], No. 14836/70. Heading C5D. [Also in Division C2] A wash powder having detergent and biodegradable properties comprises an alkali metal or ammonium orthodialkyl benzene sulphonate wherein each of the dialkyl groups is a straight chain group and the sum of the number of carbon atoms therein is between 8 and 18, sodium pyrophosphate, sodium perborate, colloidal magnesium silicate, anhydrous sodium carbonate, anhydrous sodium sulphate, carboxymethyl cellulose.