baber/WOPTO huggingface dataset:
Patent NZ-501318-A (NZ)
Title: Medicaments containing 25 hydroxy vitamin D (calcitriol) derivatives
Inventor: DELUCA HECTOR F
IPC: A61P3/00
Filed: 1996-09-20
Abstract: The in vivo release of vitamin D compounds may be regulated by derivatizing the hydroxy group at carbon 25 with an acyl group or a hydrocarbyloxycarbonyl group to obtain a vitamin D derivative of formula (I).  These compounds may be used in medicaments for the treatment of disease states resulting form calcium metabolism disorders. In formula (I); R5 and R6 represent hydrogen, or taken together R5 and R6 are methylene; R is represented by the structure 1, where the stereochemical centre at carbon 20 in the side chain may have the R or S configuration; Z is selected from Y, -OY, -CH2OY, C CY and CH = CHY, where the double bond may have the cis or trans stereochemical configuration; Y is selected from a radical of the structure 2; m and n, independently, represent the integers from 0 to 5; R1 is selected from the group consisting of hydrogen, OX4, fluoro, trifluoromethyl and C1-5- alkyl, which may be straight chain or branched and, optionally, bear a hydroxy substituent; R2 is selected from the group consisting of hydrogen, fluoro, trifluoromethyl and C15 alkyl, which may be straight-chain or branched, and optionally, bear a hydroxy substituent; and R3 and R4 are selected from trifluoromethyl and C15 alkyl, which may be straight chain or branched and optionally bear a hydroxy substituent; or R1 and R2 taken together, represent an oxo group, or an alkylidene group, =CR2R2, =CR2R3, or the group -(CH2)p-, where p is an integer from 2 to 5; or R3 and R4, taken together, represent the group (CH2)q-,  where q is an integer from 2 to 5; X1, X2, and X4 are each hydrogen, an acyl group, or a hydrocarbyloxycarbonyl group; and X3 represents an acyl group or a hydrocarbyloxycarbonyl group.
Patent NZ-502321-A (NZ)
Title: Tri-height folding stage
Inventor: ANDERT GARY W
IPC: E04H3/24
Filed: 1998-06-17
Abstract: Provided is a folding stage 20, comprising a frame 22, stage decks 24 mounted to frame 22 which form an extended stage surface, a linkage 40 folding the stage along a center axis from a use position to a folded storage position and telescoping legs 32 are associated with each of stage decks 24.  Each of telescoping legs 32 includes an outer telescoping member 50, an inner telescoping member 52 inserted into the outer rectangular member.  Inner telescoping member 52, 68 has a mounting portion.  Telescoping legs 32, 34 have a spreader member 86 having an orifice formed therethrough.  A spacer member 82 has a bore formed therethrough and a plurality of tabs 84 extending axially upward and radially outward.  A connector member 92 is inserted through the orifice and the bore and to the mounting portion.
Patent NZ-506529-A (NZ)
Title: Treatment of follicular lymphomas using inhibitors of the lymphotoxin (LT) pathway
Inventor: BROWNING JEFFREY
IPC: A61K35/12
Filed: 1999-01-29
Abstract: The use of an effective amount of a composition which inhibits the interaction between LT-B and its receptor in the manufacture of a medicament for arresting or reducing the advancement, severity or effects of a tumor in a subject.
Patent NZ-507109-A (NZ)
Title: Ternary polymer blend, the film containing it, and the easy-to-open package made therewith
Inventor: LONGO EUGENIO
IPC: B65D75/58
Filed: 1999-04-09
Abstract: An extrudable blend comprising polymers useable as layers for an easy to open package  is described.  The blend comprises (i) a copolymer of ethylene and acrylic acid or methacrylic acid, (ii) a modified EVA copolymer and (iii) a polybutylene. Included are the films comprising the blend in the sealant layer or in a layer directly adhered to the sealant layer, and the easy-to-open packages obtained therefrom.
Patent NZ-508065-A (NZ)
Title: Fumaric acid monoalkyl ester salt optionally with dialkyl fumarate micro-tablets or micro-pellets are useful for treating psoriatic arthritis, neurodermatitis, psoriasis or enteritis regionalis Chron
Inventor: JOSHI RAJENDRA KUMAR
IPC: A61K9/50
Filed: 1999-10-08
Abstract: A fumaric acid monoalkyl ester salt of formula (I) optionally in an admixture with a dialkyl fumarate of formula (II) optionally with a pharmaceutical acceptable carrier is used in manufacture of a pharmaceutical composition in the form of micro-tablets or micro-pellets for treating psoriatic arthritis, neurodermatitis, psoriasis or enteritis regionalis Chron. In formula (I): n is 1 or 2 and A is Ca, Mg, Zn, Fe, Li, Na or K.
Patent NZ-508119-A (NZ)
Title: Humanized antibodies that bind specifically to verotoxin II (VT2) and/or VT2 variant and the B subunits thereof
Inventor: CO MAN SUNG
IPC: A61K31/04
Filed: 1999-05-19
Abstract: Described are humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2).  The antibodies are useful for treating patients suffering from, or at risk of suffering, toxic effects of verotoxin.
Patent NZ-510992-A (NZ)
Title: Reclosable seal, package, method and apparatus with arrow shaped reclosable complementary fasteners, and strip to form this sealed substantially only at top to sheet
Inventor: FORMAN HAROLD M
IPC: B31B50/64
Filed: 2001-04-06
Abstract: Discrete strips 31 are each attached to packing film 32 at top edges only and are formed into complementary inter-engaging portions of a re-closable fastener.
Patent NZ-512397-A (NZ)
Title: Internally ribbed filter cartridge and process
Inventor: WINTER JOSEF
IPC: B01D39/18
Filed: 1999-12-17
Abstract: An injection moulding assembly (10) comprising a male moulding member (11) surrounded by a female moulding member (12) forming a void (13) between them that upon injection of molten plastics into the mould a container can be formed. The moulding assembly includes a guide rod (14) and ejection flange (16) and a pair of ejection flange guide rods (17 and 18), an air vent valve (15) and an injection passage (19). The male member (11) includes in this embodiment eight grooves (20) unevenly spaced so that the partially hardened container formed in the injection mould can be pushed from the mould using the ejection flange (16) while the container is sufficiently green to enable the ribs formed in the grooves (20) to move over the surface of the male mould (11) during the ejection process.
Patent NZ-514269-A (NZ)
Title: Substituted 1,4-dihydroindeno[1,2-c]pyrazoles useful as inhibitors of tyrosine kinase
Inventor: TURNER ALLYSON
IPC: C07D495/04
Filed: 2000-03-28
Abstract: A 1,4-dihydroindeno[1,2-c]pyrazole derivatives or pharmaceutically acceptable salts thereof has the formula (I) wherein: L1 is (E)2(CH2)q with the alkylene chain (CH2)q being optionally substituted; E is NR24. O or S; s is 0 or 1 and q is 0 to 6, provided that when s is 1 q is at least 1; A is CONH, NHCO, SO2NH, NHSO2, or NR25; L2 is (CH2)r which can be optionally substituted; r is 0 to 6; R2 is optionally substituted alkyl, amino or alkoxy or halo, hydroxy, cyano, nitro, carbamoyl, alkanoyl or alkoxycarbonyl; n is 0, 1, 2 or 3; X is substituted methylene, carbonyl, oxygen, C=NOR7, NR8, (CH2)n' or S(O)p; p is 0, 1 or 2; R7 is H or alkyl; R8 is H or optionally substituted alkyl or phenyl; n' is 1, 2 or 3, R3 to R6 are independently H, halo, optionally substituted alkyl, alkenyl, alkynyl, phenyl alkyl, phenyl alkoxy, amino, alkoxy or phenoxy, hydroxy, CORa, alkanoyl, nitro, cyano, Ra is hydroxy, alkoxy or optionally substituted amino; a) when A is SO2NH, or NHSO2 R1 is alkoxy, amino, optionally substituted phenyl, heteroaryl or a five, six or seven membered saturated heterocyclic ring containing a nitrogen atom which optionally contains an additional hetero atom selected from O, S or N or b) when A is CONH or NHCO R1 is substituted phenyl or optionally substituted heteroaryl or a five, six or seven membered saturated heterocyclic ring containing a nitrogen atom which optionally contains an additional hetero atom selected from O, S or N or c) when A is a group NR25 and q is at least 1 then R1 is optionally substituted phenyl, heteroaryl or amino or d) when A is a group NR25 and q is 0 and s is 0 then R1 is optionally substituted heteroaryl; R24 and R25 are as defined in the specification provided that no two heteroatoms are attached to the same sp3 hybridized carbon atom. The compounds are useful for treating burns, chronic lung disease, stroke, polyps, psoriasis, allergic inflammation, macular degeneration, diabetic retinopathy, ovarian hyperstimulation syndrome or brain tumor-associated cerebral edema.
Patent NZ-516111-A (NZ)
Title: Phenoxypropylamine compounds useful to treat depression
Inventor: NISHIYAMA AKIRA
IPC: C07D491/10
Filed: 2000-05-22
Abstract: A phenoxypropylamine derivative or an optically active compound, a pharmaceutically acceptable salt or a hydrate thereof has the formula (I) wherein: a dotted line shows a double bond or a single bond; X is hydrogen, hydroxy, alkoxy, acyloxy or oxo; R is a group of formula 1, 2, 3 or 4; Y is O or S, m and n are each independently 0, 1 or 2; Z is absent or -CH2-; R3 is hydrogen, alkyl or a halogen; V is -CH2-, -O-, -S- or -N(R4)-; W is absent or -CH2- or -C(=O)-; or R7 is hydroxyalkyl, acyl, optionally substituted optionally saturated heterocyclic, optionally substituted fused heterocyclic, alkylsulphonyl or -Q-R9 R7 and W in combination may form a ring of formula 14; Q, R9, R2, R5, R6, R4 and QÆ are as defined in the specification; E is oxygen or sulphur, and Ra, Rb and Rc are each independently hydrogen, alkyl, hydroxy, alkoxy, halogen, acyl, nitro or amino; provided that when R7 and W are form a ring of formula 14 Ra to Rc are not each OH or alkoxy. The above compounds are useful to treat depression.
Patent NZ-520231-A (NZ)
Title: Water purifier with sintered activated carbon/ceramic filter block
Inventor: TOCHIKUBO SHIGEO
IPC: C02F1/28
Filed: 2002-07-17
Abstract: A water purifier includes a chamber housing a filter block for purifying water flowed through the chamber. The filter block is formed as a sintered activated carbon block with a plurality of pores. An activated carbon powder is sintered together with a ceramic binder to form the block. The average diameter of the binder particles is 150 micrometers or less and the binder does not include phosphorous pentaoxide (P2O5).
Patent NZ-522347-A (NZ)
Title: Heating, cooking, and sterilizing device
Inventor: ONO TAKUJI
IPC: A23L3/24
Filed: 2001-04-23
Abstract: A cooking apparatus and a preservative food preparing apparatus have been known and practically used exclusively for the purpose of cooking foods or preparing preservative foods. There has been an increasing demand for a cooking-and-preservative food preparing apparatus. To meet this demand, a heating, cooking, and sterilizing apparatus according to the present invention is constructed as follows: a horizontal type of cylindrical heating-and-cooking oven 1 has numerous nozzles 7 provided therein. These nozzles 7 are connected to the outlet 37 of a heat exchanger 25 positioned outside of the oven 1, and the bottom of the oven 1 is connected to the inlet 38 of the heat exchanger 25 via a return pipe 43, which is fixed to the bottom of the oven 1, thus forming a circulation line between the oven 1 and the heat exchanger 25. A circulation pump 40 is included in the circulation line. First and second tanks 42 and 51 are connected at their outlets to the drawing side of the circulation pump 40, and at their inlets to the discharging side of the circulation pump 40 in such a way that the first and second tanks 42 and 51 may be selectively connected to the heat exchanger 25. A washing water tank 67 is selectively connected to the first and second tanks 42 and 51, and the oven 1 can be connected to a compressed air supply source 19 and an inert gas source. The oven is equipped with different sensors 9 to 12 for monitoring some factors. A control section is responsive to the signals from these sensors 9 to 12 for controlling the temperature of the heat exchanger 25 and the inner pressure of the oven 1, and for permitting the nozzles 7 to eject an aqueous seasoning solution, steam, hot water or cooling water according to the software program installed in the control section.
Patent NZ-523889-A (NZ)
Title: Determination of velocities of molecular species in electrophoresis
Inventor: SIDERIS DIMITROIS
IPC: G01N27/447
Filed: 2001-07-20
Abstract: The velocities of migrating objects, such as molecular species in an electrophoretic experiment, are determined by generating a space-time map of points representing the signal peaks of signals detected at a plurality of spaced positions and identifying at least one vertex from the space-time map.  A single vertex is identified for each group of objects having a common constraint and the velocities of the objects are determined from the set of points in the space-time map corresponding to the respective objects as fitted to the respective vertex.
Patent NZ-524366-A (NZ)
Title: Methods for enhancing targeted gene alteration using oligonucleotides
Inventor: KMIEC ERIC B
IPC: A61K38/00
Filed: 2001-07-27
Abstract: A method of enhancing oligonucleotide-mediated gene alteration efficiency comprising administering said oligonucleotide to a non-human cell, or a cell-free extract, with reduced levels or activity of at least one protein selected from the group consisting of the Saccharomyces cerevisiae proteins RAD1, RAD51, RAD52, RAD57 and PMS1, and any homolog, ortholog or paralog thereof.
Patent NZ-524792-A (NZ)
Title: Use of imidazoquinolinamines as adjuvants in DNA vaccination
Inventor: THOMSEN LINDY LOUISE
IPC: C07D471/04
Filed: 2001-09-20
Abstract: Disclosed herein is a vaccine composition and use of a 1H-imidazo[4,5-c]-4-amine derivative as an adjuvant for use with nucleic acid vaccination, wherein a vaccine composition comprises (i) an adjuvant component comprising a 1H-imidazo[4,5-c]quinolin-4-amine derivative and (ii) an immunogen component comprising a nucleotide sequence encoding an antigenic peptide or protein associated with a disease state, wherein the adjuvant component enhances the immune responses in a mammal to the antigenic peptide or protein.
Patent NZ-528404-A (NZ)
Title: Intervertebral space implant for use in spinal fusion procedures
Inventor: GLENN BRADLEY J
IPC: A61F2/30
Filed: 2002-03-22
Abstract: An implant assembly (10) is provided for surgical implantation into an intervertebral space (S) such as for stabilization of vertebrae (V) adjacent the intervertebral space (S) during a spinal fusion procedure. The implant assembly includes a primary segment (20) separate from a secondary segment (60). These segments (20, 60) are elongate and of sufficiently small cross-section that they can be implanted posteriorly in a minimally invasive manner. The primary segment preferably includes a tunnel (30) and the secondary segment preferably includes a neck (70) with the tunnel and neck sized complemental so that the segments stabilize each other where they intersect with the neck within the tunnel. The entire implant assembly is thus provided which both widens and supports the intervertebral space and is sufficiently rigid to provide adequate support for the intervertebral space as the vertebrae are fusing together.
Patent NZ-529920-A (NZ)
Title: Sulphinic acid derivatives useful in gastro-reflux disease
Inventor: FITZPATRICK KEVIN
IPC: C07C313/04
Filed: 2002-06-04
Abstract: A compound of formula (I) is described to be used in the manufacture of a medicament for the treatment of conditions such as gastro-oesophageal reflux disease (GORD), regurgitation in infants, belching, hyperkinesia, emesis and dyspepsia. R1, R3 and R4 in formula (I) represent hydrogen; and R2 represents hydroxyl, fluoro or an oxo group. The racemate of (3-amino-2-hydroxypropyl)sulphinic acid is an exception. It is disclosed that the compound, racemate or a stereoisomer thereof may exist in the form of a pharmaceutically acceptable salt and/or solvate thereof.
Patent NZ-532499-A (NZ)
Title: Method for producing coating layers
Inventor: BELIK PAVEL
IPC: C09D4/06
Filed: 2002-11-21
Abstract: A method of coating a surface is disclosed, wherein a coating material having a viscosity less than 100 Pa.s, measured at 25 DEG C., is applied to a surface to be coated, and is cured, wherein the coating material comprises a reactive resin comprising components: (A) 1 part by weight of at least one ethylenically unsaturated compound, (B) 0-2 parts by weight of a (pre)polymer swellable or soluble in component (A), (C) 0 to 0.15 parts by weight of at least one paraffin and/or wax, (D) a redox system wherein at least one component of the redox system is to be kept separate until the polymerization of the polymerizable constituents of the system, wherein the redox system comprises an accelerant and a peroxide catalyst or initiator in an amount sufficient for the cold curing of component (A), and (E) customary additives and a gas flow is passed over the surface to be coated, during the application of the coating material, by means of at least one mobile overpressure ventilation device (F) component (E) in an amount in the range from 0 to 100 parts by weight per 10 parts by weight of components (A+B).
Patent NZ-533568-A (NZ)
Title: Condensed hexacyclic camptothecin compounds as antitumor agents
Inventor: MURATA TAKESHI
IPC: A61P43/00
Filed: 2002-11-25
Abstract: Condensed hexacyclic camptothecin compounds of the formula [1] and pharmaceutically acceptable salts thereof that are suitable as antitumor agents are disclosed, wherein Z, R1, R2, R3 and R4 are as defined in the specification. These compounds are useful in the treatment of cell proliferative disorders such as colorectal cancer, lung cancer, breast cancer, stomach cancer, cervical cancer and bladder cancer.
Patent NZ-537502-A (NZ)
Title: Process for producing a virus-inactivated thrombin preparation
Inventor: CONNOLLY CAROLINE
IPC: A61K38/00
Filed: 2003-07-07
Abstract: A method for the preparation of a virus-inactivated thrombin comprising solvent-detergent virus inactivation of a solution comprising prothrombin and factor X, loading the virus inactivated prothrombin and factor X on an anion exchange medium, washing the medium to remove the reagents used for the solvent-detergent virus inactivation and activating the prothrombin on the medium to form thrombin by the addition of metal ions. The final step is selectively eluting the thrombin from the anion exchange medium.
Patent NZ-542088-A (NZ)
Title: Composition and method for the treatment and prevention of enteric bacterial infections
Inventor: ROBINS-BROWNE ROY MICHAEL
IPC: C07K16/04
Filed: 2004-03-04
Abstract: A method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.
Patent NZ-548798-A (NZ)
Title: Swinging agitator for a gypsum calcining apparatus and the like
Inventor: BOLIND MICHAEL L
IPC: F27D99/00
Filed: 2005-02-10
Abstract: An agitation mechanism 60 for a gypsum processing apparatus 10 which includes a housing 12 having a bottom wall 14, at least one side wall 18, and a support base 23 above and adjacent the bottom wall 14, a fluidization mechanism for introducing fluid to the gypsum based product, the fluidization mechanism defining at least a portion of the support base 23 of the housing 12, a burner conduit 28 extending through the housing 12 from at least one burner 22 and terminating through the support base 23 such that combustion gases from the burner 22 travel through the burner conduit 28 in the housing 12 and through the support base 23 including the fluidization pad 54 back through the housing 12 and the gypsum based product, and an agitator frame 64 having a similarly shaped cross section to a cross section of the housing 12, the agitator frame 64 pivotally connected internally to the housing 12 for reciprocating movement between first and second positions. The housing 12 is designed and constructed to receive and process powdered gypsum. The agitation mechanism 62 prevents the gypsum products from collecting adjacent to the bottom wall 14 of the housing 12.
Patent NZ-556079-A (NZ)
Title: Two thermoplastic films laminated via low melting point intermediate and with perforations non-aligned and interconnected via channels
Inventor: RASMUSSEN OLE-BENDT
IPC: B29C55/18
Filed: 2006-01-05
Abstract: A laminate of thermoplastic film materials exhibiting throughgoing porosity and comprising plies A and B, A having an inner surface A1 partly in contact with B and an outer surface A2, and B having an inner surface B1 partly in contact with A and an outer surface B2, A and B consisting of continuous material except for a multitude of perforations in each ply, whereby essentially no perforation in A corresponds directly to a perforation in B, the lamination between A and B on surfaces A1 and B1 being a) through a coextruded lower melting lamination layer on A and/or B and b) established in such discontinuous manner that there is formed a channel system between A1 and B1 connecting the majority of the perforations in A each with at least one of the perforations in B, and connecting the majority of the perforations in B each with at least one of the perforations in A is provided in addition to a process and apparatus for producing such a laminate.
Patent NZ-562199-A (NZ)
Title: Hydroxybenzamide derivatives and their use as inhibitors of HSP90
Inventor: CHESSARI GIANNI
IPC: A61K31/403
Filed: 2006-04-13
Abstract: Disclosed is a compound of formula (VI), or a salt, solvate, tautomer, or N-oxide thereof, wherein T and Q are both CH2, B is phenyl or pyridine, and the other substituents are as defined in the specification. Also disclosed is the use of the compound as a Hsp90 inhibitor, and for treating proliferative disorders such as cancer. Also disclosed is a process for preparing the compound.
Patent NZ-564136-A (NZ)
Title: Colourant compositions
Inventor: GRAVES STEPHEN JOHN
IPC: C08L33/00
Filed: 2007-12-10
Abstract: Disclosed is a water based colouring composition adapted to be used with a material having substantially porous surface, which composition comprises a emulsion or solution of (a) at least one pigment; (b) at least one acrylate polymer or copolymer; (c) at least one silane-type binding agent; and the remainder being water; wherein the composition penetrates the substantially porous surface of the material, forming a physiochemical bond therewith.
Patent NZ-564484-A (NZ)
Title: Method of preparing microfibrillar cellulose
Inventor: HEIJNESSON-HULTEN ANETTE
IPC: C08B1/00
Filed: 2006-05-30
Abstract: Disclosed is a method of preparing microfibrillar cellulose comprising treating cellulose fibers in an aqueous suspension comprising an oxidant and at least one transition metal in ionic form, mechanically delaminating said cellulose fibers such that microfibrillar cellulose is formed.
Patent NZ-569407-A (NZ)
Title: Power distribution system with individually isolatable functional zones
Inventor: ROSS BRADLEY LEIGHTON
IPC: H02B1/24
Filed: 2006-12-20
Abstract: An electrical distribution apparatus is disclosed, which includes several feeders respectively terminating inside several insulative compartments. The feeders can be connected to, and isolated from, each other by several isolating devices respectively associated with, but external to, the several insulative compartments, so that in use electrical work can be safely performed on respective isolated feeders inside respective insulative compartments while the other feeders remain energised.