baber/WOPTO huggingface dataset:
Patent CO-6231000-A2 (CO)
Title: Anticuerpos contra de erbb3 y usos de los mismos
Inventor: SCHOEBERL BIRGIT
IPC: A61K33/243
Filed: 2009-09-16
Abstract: 1.- Un anticuerpo monoclonal aislado o porción de unión a antígeno del mismo que se une al ErbB3 e inhibe la fosforilación mediada por betacelulina del ErbB3 que ocurre a través del ErbB1. 2.- El anticuerpo o porción de unión a antígeno del mismo de la reivindicación 1, en donde el anticuerpo o porción de unión a antígeno del mismo no compite con la betacelulina por unión a las células ADR. 3.- El anticuerpo o porción de unión a antígeno del mismo de una cualquiera de las reivindicaciones precedentes, en donde el anticuerpo o porción de unión a antígeno del mismo adicionalmente inhibe la unión de la heregulina al ErbB3. 4.- El anticuerpo o porción de unión a antígeno del mismo de una cualquiera de las reivindicaciones precedentes, en donde anticuerpo o porción de unión a antígeno del mismo exhibe una o más de las siguientes propiedades: (i) inhibición de señalización mediada por epiregulina a través del ErbB3; (ii) inhibición de proliferación de células que expresan ErbB3; (iii) la capacidad de reducir los niveles de ErbB3 sobre superficies celulares; (iv) inhibición de secreción VEGF de células que expresan ErbB3; (v) inhibición de la migración de células que expresan ErbB3; (vi) inhibición de crecimiento esferoide de células que expresan ErbB3; y/o (vii) unión a un epítopo localizado en el dominio I del ErbB3. 5.- El anticuerpo o porción de unión a antígeno del mismo de una cualquiera de las reivindicaciones precedentes, en donde el anticuerpo o porción de unión a antígeno del mismo se une al ErbB3 con un KD de por lo menos aproximadamente 8 nM o mejor, cuando se mide por un ensayo de resonancia de plasmón de superficie o un ensayo de unión celular. 6.- El anticuerpo o porción de unión a antígeno del mismo de una cualquiera de las reivindicaciones 1 a 5, en donde el anticuerpo o porción de unión a antígeno del mismo comprende una región variable de cadena pesada que comprende una secuencia de aminoácido por lo menos 80% idéntica a la secuencia de aminoácido de región variable de cadena pesada establecida en la SEQ ID NO: 1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:35, o SEQ ID NO:37.
Patent CO-6260063-A2 (CO)
Title: Disolucion directa del docetaxel en un disolvente en polisorbato 80
Inventor: AUTHELIN JEAN RENE
IPC: A61K31/337
Filed: 2009-10-28
Abstract: La invención se refiere a la solubilización del docetaxel en un disolvente orgánico, a su mezcla con polisorbato 80 y a la evaporación del disolvente. 1.- Procedimiento de preparación de una disolución de docetaxel en polisorbato 80 caracterizado porque se disuelve el docetaxel en un disolvente orgánico que tiene un punto de ebullición comprendido entre 40 y 153°C, con la excepción del etanol, se mezcla la disolución obtenida con polisorbato 80 y se evapora bajo presión reducida el disolvente de disolución.2.- Procedimiento según la reivindicación 1 caracterizadoporque el docetaxel está en forma cristalina.3.- Procedimiento según la reivindicación 2 caracterizado porque el docetaxel está en forma de trihidrato, de acetonato o de solvato de acetonitrilo.4.- Procedimiento según la reivindicación 1 caracterizado porque el disolvente de disolución se elige entre acetona, acetonitrilo, cloruro de metileno o DMF.
Patent CO-6241137-A2 (CO)
Title: Antagonistas ciclicos de peptido cxcr4
Inventor: KOHN WAYNE DAVID
IPC: A61K38/12
Filed: 2009-11-27
Abstract: 1.- Un péptido ciclizado por lactamas de fórmula I:R1 - ciclo[X1 - Tyr - X3 - DArg - 2Nal - Gly - X7] - X8 - X9 -caracterizado porque:a) la lactama se forma por un enlace amida entre el grupo amino de cadena lateral de X1 y el grupo carboxilo de cadena lateral de X7, en donde X1 y X7 son, respectivame, un par seleccionado del grupo que consiste de (D/L)Agl/Glu, Dab/Glu, y Dap/Glu, y R1 es Ac o n-hexanoilo; o b) la lactama se forma por un enlace amida entre el grupo carboxilo de cadena lateral de X1 y el grupo amino de grupo cadena lateral de X7, en donde X1 y X7 son, respectivamente, un par seleccionado del grupo que consiste de Asp/(D/L)Agl, Asp/Dab, Asp/Dap, Glu/(D/L)Agl, Glu/Dab, Glu/Dap, Glu/DDap, y Glu/Lys, y R1 es Ac o Bz, o en donde X1 y X7 son, respectivamente, un par seleccionado del grupo que consiste de succinilo/ (D/L)Agl, succinilo/Dab, succinilo/DaP, succinilo/Lys, y succinilo/Orn, y R1 está ausente; o c) la lactama se forma por un enlace amida entre el grupo a-amino de X1 y el grupo carboxilo de cadena lateral de X7, en donde X1 y X7 son, respectivamente, un par seleccionado del grupo que consiste de Ala/Glu, Ala/DGlu, DAla/Glu, DAla/DGlu, Dap(Ac)/Glu, Gly/Asp, Gly/Glu, Gly/DGlu, Leu/Glu, Leu/DGlu, Lys/DGlu, Lys(Ac)/Glu, 2Nal/Glu, Phe/Glu, Phe/DGlu, DPhe/Glu, y DPhe/DGlu, y R1 está ausente; o d) la lactama se forma por un enlace amida entre un grupo amino no a, sin cadena lateral de X1 y el grupo carboxilo de cadena lateral de X7, en donde X1 y X7 son, respectivamente, un par seleccionado del grupo que consiste de ß-Ala/Asp, -Ala/Glu, 5-amino-valerilo/Asp, 5- aminovalerilo/Glu, 4-AMB/Glu, 4-AMPA/Asp, y 4-AMPA/Glu, y R1 está ausente; o e) la lantana se forma por un enlace amida entre el grupo a-amino de X2 y el grupo carboxilo de cadena lateral de X7, en donde X2 y X7 son, respectivamente, un par seleccionado del grupo que consiste de Tyr/Asp, Tyr/Glu, y Tyr/DGlu, y R1 y X1 están cada uno ausentes; R1 es un sustituyente sobre el grupo a-amino de X1 cuando X1 contiene un grupo a-amino y el grupo a-amino no es un constituyente del enlace amida de la lactama, seleccionado del grupo que consiste de Ac, Bz, y n-hexanoilo, o está ausente, en donde X1 es seleccionado del grupo que consiste de (D/L)Agl, Asp, Dab, Dap, y Glu;X1 es seleccionado del grupo que consiste de (D/L)Agl, Ala, -ß-Ala, DAla, 5-aminovalerilo, 4-AMB, ...
Patent CO-6290628-A2 (CO)
Title: Composición oral que incorpora un amino ácido y fluoruro
Inventor: KOHLI RAJNISH
IPC: A61K8/44
Filed: 2010-09-03
Abstract: Esta invención se refiere a composiciones para cuidado oral que comprende una cantidad efectiva de un aminoácido básico en forma libre o en forma de sal y una baja dosificación de fluoruro y a métodos para usar tales composiciones.
Patent CO-6491118-A2 (CO)
Title: Anticuerpos humanos de alta afinidad para la angiopoyetina-2 humana
Inventor: THURSTON GAVIN
IPC: C07K16/22
Filed: 2012-02-06
Abstract: La presente invención proporciona anticuerpos que se unen a la angiopoyetina-2 (Ang-2) y métodos para el uso de los mismos. Según ciertas realizaciones de la invención, los anticuerpos son anticuerpos humanos completos que se unen a la Ang-2 humana. Los anticuerpos de la invención son útiles, entre otras cosas, para el tratamiento de enfermedades y trastornos asociados con una o más actividades biológicas de la Ang-2 incluyendo la angiogénesis.
Patent DD-151511-A2 (DD)
Title: Schaltungsanordnung zur digitalen effektivwertmessung
Inventor: FIEGENBAUM WILFRIED
IPC: G01R19/02
Filed: 1979-02-09
Abstract: Die Erfindung betrifft eine Schaltungsanordnung zur digitalen
Effektivwertmessung in Geräten der elektronischer» Meßtechnik in
Ausgestaltung der Erfindung nach WP 140 923. Ziel der Erfindung
ist ea, die Genauigkeit der Effekt!vwertnassung zu verbessern.
Die Aufgabe der Erfindung besteht darin, eine schaltungstechnische
Lösung zu schaffen, durch deren Einsatz die
genauigkeitsbegrenzenden Eigenschaften den quadrierenden
Analog-Frequenz-ümsetzerc reduziert werden. Erfindungsgemäß ist die
Aufgabe in einer Schaltungsanordnung mit einem radizierenden
'ptfferenzbildner und einen speziellen Phasenregelkreis zur
"dynchronisaticu der Ausgangsfrequenz auf eine Rofercnzfrequenz gelöst.
Dar Phasenregelkreis besteht aus einem Lcistungssununierer, einem
IJ/A-Umsetzer, einem Analog-Frequenz-ümsatzer und einer digitalisierenden
Phasenvsrgleichsschal.tung. Dem Phasenregelkreis ist
hinsichtlich der Ausgangsfreguens und eines. Digitalwertes der
radizierende Differenzbildner, bestehend aus einem Frequenzteiler,
einem VorwSrtszähler, einem Vor-Rückwärtszähler, einer
Ladeschaltung, einer fießvertausgabs sowie einem Zählrichtungsumschalter,
nachycsetzt. Dor zeitlich koordinierte Ablauf ist mit
einer ßteuerschaitung realisiert. Die Bchaltungsanordnung ist bei
stark vorSnderlichem Verlauf der zu messenden Gleich- oder/und
Wechselgrößcn anwendbar. - Figur —
Patent DD-155529-A2 (DD)
Title: Einrichtung zur grossflaechigen abscheidung von haftfesten,insbesondere harten kohlenstoffschichten
Inventor: BOLLINGER HELMUT
Filed: 1980-12-19
Abstract: Die Erfindung betrifft eine Einrichtung zur grossflaechigen Abscheidung von haftfesten, insbesondere harten Kohlenstoffschichten auf Substraten mittels ionisierter Gase und/oder Daempfe nach Patent 146307, wobei die aus Reflektorelektroden und deren Halterungen gebildeten Entladungskammern, die durch auf positivem Potential liegende Gitter begrenzt werden, den Substrathalter umschliessen. Die Gluehkatoden sind, je nach zu beschichtenden Substraten, horizontal oder vertikal in den Entladungskammern angeordnet und ermoeglichen, dass beliebig geformte Substrate allseitig mit verschleissfesten Schichten, insbesondere Kohlenstoffschichten, haftfest beschichtet werden koennen, wobei stabile Entladungsverhaeltnisse und eine stabile Betriebsweise vorherrschen.
Patent DD-160193-A2 (DD)
Title: Verfahren zur herstellung von polymeren esteretherm durch ringoeffnungspolymerisation
Inventor: KLEMM ELISABETH
IPC: C08G65/10
Filed: 1981-03-27
Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung von polymeren Esterethern durch Ringoeffnungspolymerisation, die als transparente Medien Anwendung in der optischen Industrie finden koennen. Sie koennen aber auch als spannungsfreie Kitte fuer Metalle und aehnliche Werkstoffe bei Temperaturen unterhalb 0 Grad C verwendet werden sowie als elastische Komponente in Polymerblends eingesetzt werden.Es ist das Ziel der Erfindung, ein Verfahren zu entwickeln, das es gestattet, loesungsmittelfrei spirocyclische Orthoester der allgemeinen Formel I zu farblosen homogenen polymeren Esterethern II umzusetzen, die keine die Farbe und Homogenitaet beeinflussenden Produkte enthalten. Spirocyclische Orthoester der allgemeinen Formel I werden loesungsmittelfrei mit Triethyloxonium-hexachloroantimonat versetzt und fuer 4-6 Stunden auf 40-80 Grad C erwaermt. Die Menge des Initiators betraegt vorteilhaft zwischen 0,25 und 1 Gew.-%.
Patent EP-1033691-A2 (EP)
Inventor: FUCHS AXEL
IPC: G08G1/09
Filed: 2000-02-02
Abstract: A high performance service center(3) for such as vehicle components provides data that is relayed over the internet to a service provider (2). This allows a vehicle system (1) to receive and display information. Access to the system is made using a communication manager unit and the system employs Java techniques.
Patent EP-1036910-A2 (EP)
Inventor: SAUSS CHRISTIAN DIPL-ING
IPC: B60J10/24
Filed: 2000-02-17
Abstract: The seal arrangement is for a component possessing a frame (2) which has a flange pointing at right angles to the direction of movement. The flange has a profiled seal which clings tightly to the edge of the component . The flange is a profiled part (5) stuck to the frame and with a cross-sectional profile (12) locking the profiled seal (11) in place. The side of the profiled part facing the frame has a recess (8) containing adhesive (7).
Patent EP-1032039-A2 (EP)
Inventor: WEBER STEFAN J
IPC: H01H85/00
Filed: 2000-02-04
Abstract: A fuse for semiconductor devices in accordance with the present
invention includes a substrate having a conductive path disposed on a surface
thereof, a dielectric layer disposed on the substrate and a vertical fuse disposed
perpendicularly to the surface through the dielectric layer and connecting to the
conductive path, the vertical fuse forming a cavity having a liner material disposed
along vertical surfaces of the cavity, the vertical surfaces being melted to blow the
fuse. Methods for fabrication of the vertical fuse are also included.
Patent EP-1029922-A2 (EP)
Title: DNA fragments having basidiomycete-derived promoter activity and their use
Inventor: SHISHIDO KAZUO
IPC: C07K14/37
Filed: 2000-02-14
Abstract: This invention relates to a  Coriolus hirsutus  host cell
transformed with a vector containing a basidiomycete-derived
promoter region selected from the group consisting of
basidiomycete-derived  ras  and  priA  gene promoter regions. This
invention is particularly characterized in that the
basidiomycete-derived promoter region is a  Lentinus edodes -derived
 ras  or  priA  gene promoter region or a  Coriolus hirsutus -derived
 ras  gene promoter region. This host cell can be utilized for the
high productivity of lignin degrading enzymes.
Patent EP-1035692-A2 (EP)
Inventor: OKANOUE KAZUHIRO
IPC: H04L27/22
Filed: 2000-03-13
Abstract: A method of outputting a demodulation result for
soft-decision decoding is provided, which is comprised of the steps
of: (a) detecting a channel distortion of a received signal
generated in a communication channel using a training signal
contained in the received signal and a reference training signal,
outputting a channel distortion data; (b) generating a
distortion-based reliability data from the channel distortion
data; (c) compensating the received signal using the channel
distortion data, generating a compensated, received signal; (d)
demodulating the compensated, received signal and deciding the
received signal thus demodulated using a soft decision technique,
outputting a decision result; and (e) outputting a demodulation
result using the decision result and the distortion-based
reliability data. Thus, the channel distortion data (instead
of the level of the received signal) is used as the level reliability
information. As a result, the level reliability information can
be obtained independent of the demodulation data and therefore,
the necessary reliability information can be outputted with high
accuracy using a simple circuit configuration.
Patent EP-1049081-A2 (EP)
Title: Disc drive unit
Inventor: KONDO MASAMICHI
IPC: G11B19/04
Filed: 2000-04-28
Abstract: There is provided a disk drive unit which is capable of
making control corresponding to contaminant and defect by
discriminating the contaminant (dust, scratch) on the disk
surface from the defect on the recording plane. In a pull-in
signal PI corresponding to reflected light from a disk, a
defect detecting signal corresponding to a signal whose level
change is relatively quick corresponding to the defect of the
recording plane and a contaminant detecting signal which
corresponds to a signal whose level change is relatively slow
corresponding to the contaminant on the disk surface are
generated. When the defect detecting signal is at low level
for example, a system controller retries a recording operation
or increases laser light when the contaminant detecting signal
is at low level. A quantity of output light of a laser diode
is controlled so that a product of output light of a laser
diode and reflected light from the disk amounts to a
predetermined level.
Patent EP-1073137-A2 (EP)
Inventor: WIRTZ JOHN O
IPC: H01M4/73
Filed: 2000-06-23
Abstract: A battery positive grid is continuously cast of lead and thereafter
reduced in cross sectional thickness and elongated to change the microstructure of the
lead and provide enhanced corrosion resistance and other properties needed for
positive grids. The as cast thickness of the positive grids is reduced by not more than
1/2 or 2 to 1, to produce a positive grid which improves the life of a battery in which it
is used. A battery negative grid is continuously cast of lead and thereafter reduced in
cross sectional thickness and elongated to increase the ultimate tensile strength needed
for a lighter negative grid. The as cast thickness of the negative grids is reduced in the
range of about 1.2:1 to 2:1 to produce the desired properties for negative grids after
age hardening.
Patent EP-1065059-A2 (EP)
Inventor: SUZUKI YOSHIAKI
IPC: B41J2/16
Filed: 2000-06-30
Abstract: The invention provides a method for producing a
liquid discharge head including a head main body (7)
provided with plural energy generation elements (12) for
generating energy for discharging liquid as a flying
liquid droplet and plural flow paths (1) in which the
energy generation elements are respectively provided,
and an orifice plate (16) provided with plural discharge
ports (3) respectively communicating with the flow paths,
wherein the orifice plate and the head main body are
mutually adjoined, the method comprising a step of
preparing a substrate consisting of a silicon-containing
material for preparing the orifice plate a
step of forming, by dry etching, plural recesses (58) in
positions on the surface of the substrate respectively
corresponding to the discharge ports, with a depth
larger by 5 to 50 µm than the depth of the discharge
ports, a step of thinning the substrate from the
reverse side thereof until the depth of the recesses
becomes equal to the depth of the discharge apertures
to form plural discharge ports on the substrate,
thereby preparing the orifice plate constructed by
forming the plural discharge ports in the substrate,
and a step of adjoining the orifice plate to the head
main body.
Patent EP-1175115-A2 (EP)
Inventor: ARPEE JOHN
IPC: H04B7/26
Filed: 2000-09-14
Abstract: A method utilizing statistical interpolation techniques to analyze and simulate the spatial
variability and continuity of radio frequency data collected from a wireless cellular system. The
method is used for cellular system planning and management. After installation and setup of
cellular base stations, further analysis and refinement of RF data is implemented to determine
signal coverage of the tower, locations of RF holes in system, reuse of frequencies, and
overlapping RF signals between two or more towers causing interference. The method analyzes
raw RF power data that is collected by drive testing a sample of roads in a cellular system. A
geostatistical model of the RF propagation at a cellular system is determined through kriging.
The RF path loss trend estimation is extracted from each the raw data and modeled to describe
data variability across the entire cellular system area. An estimated path loss signal map is then
prepared for any area of interest within a cellular system.
Patent EP-1096350-A2 (EP)
Inventor: EDELMANN PETER
IPC: G01M13/02
Filed: 2000-10-27
Abstract: The device has an arrangement (6) for coupling to a controller for the components, especially. an electronic controller, to read out at least one parameter describing the operation of the components and an arrangement (2) for wireless data communications with an evaluation and/or monitoring and/or control system or a data communications switching device  Independent claims are also included for an arrangement for a service system and for a method of monitoring component operation.
Patent EP-1126251-A2 (EP)
Inventor: BILJON CLIVE VAN
IPC: G01F23/284
Filed: 2000-12-08
Abstract: Device comprises a main tank (1) and an adjacent bypass pipe linked to the main tank by upper and lower cross pipes (9, 11). A microwave measurement device (21) is arranged at the top of the bypass pipe in to measure the level of the fluid in the bypass pipe that is the same as that in the main tank. An additional microwave waveguide (25) is positioned below the measurement device adjacent to the upper cross pipe.
Patent EP-1108741-A2 (EP)
Inventor: MIKI TAKATOSHI
IPC: C08J5/18
Filed: 2000-12-08
Abstract: The present invention relates to a polyester film for
medicine wrapper or powder food wrapper having a surface
resistivity of not more than 5 × 10 12  Ω/cm 2 .
Patent EP-1138620-A2 (EP)
Inventor: VEENSTRA PIETER
IPC: B65H18/20
Filed: 2000-12-15
Abstract: The web of paper or carton is fed through a longitudinal cutter where it is sub-divided into two individual webs. The web passes over two supporting rollers (6,7). Before reaching the first roller (6) the web passes through a tension interruptor unit which has a powered roller (8). The output supporting roller (7) turns under power. The input roller (6) moves freely and is not powered.
Patent EP-1098330-A2 (EP)
Inventor: KRAMER RODNEY
IPC: H01H9/34
Filed: 2000-10-31
Abstract: A multi-phase circuit breaker assembly 10 includes a circuit
breaker 12 having a housing 13 containing circuit breaker operating
components and having a gas venting chamber 22 associated with each
phase of the circuit breaker. The circuit breaker has a plurality of line
wiring terminals 26 at a first end 14 of the housing. Each line wiring
terminal corresponds to a phase of the circuit breaker. A terminal cover
30 is removably coupled to the first end of the housing so as to cover the
line wiring terminals and prevent access to the line wiring terminals
when coupled to the first end of the housing, and to gain access to the
line wiring terminals only when removed from the first end of the
housing. The terminal cover 30 includes a plurality of vent structures 38
integrally formed therewith. Each vent structure is in communication
with an associated gas venting chamber and each vent structure is
isolated from each other such that arc gases generated in each phase of
the circuit breaker are exhausted through an associated vent structure
with arc gases from one phase being prevented 1) from coming into
contact with arc gases or line wiring terminals of a different phase, and
2) from coming into contact with wiring terminals of the same phase,
thereby preventing a short circuit.
Patent EP-1022889-A2 (EP)
Inventor: COOK WENDY S
IPC: H04M3/51
Filed: 2000-01-13
Abstract: A method and system for transferring telephone calls and data
between computer programs in a call center. Flow connection modules associated
with call center application programs allow data and telephone calls to be transferred
from one computer program to another in the call center. The flow connection
modules may be combined with a locator program such that the combination replaces
the automatic call distributor ("ACD") in a call center. The flow connection modules
enable development of modular call centers, allowing call center agent workstations
to be easily increased or decreased. In operation, an application notifies its flow
connection module that a call on a telephone in the workstation should be transferred
to another application. The flow connection module establishes a data connection
with a flow connection module associated with the other application. The flow
connection module sends call-related data to the other flow connection module
which then returns the telephone extension associated with the other application.
The flow connection module requests a computer telephony interface ("CTI") link
associated with a phone switch to transfer the call to the other application's
telephone. The CTI link directs the phone switch to transfer the telephone call from
the original application's workstation to the telephone of the other workstation.
Having received notification of the transferred call, the other flow connection module
informs the original flow connection module that the call has been successfully
transferred, and the original flow connection module then disconnects the data
connection.