baber/WOPTO huggingface dataset:
Patent WO-2019023706-A1 (WO)
Title: Ultrasound-sensitive peptide particles for spatially resolved molecule delivery
Inventor: SCHNEIDER JOEL
IPC: A61K9/22
Filed: 2018-07-30
Abstract: The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon. liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence, CL is a cross-linking motif, and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, wherein the cell may be in vitro, ex vivo, or in vivo.
Patent WO-2019032959-A1 (WO)
Title: Methods and compositions relating to emulsions comprising fish oil and/or omega-3 fatty acids
Inventor: PUDER MARK
IPC: A61K31/202
Filed: 2018-08-10
Abstract: Described herein are emulsion compositions comprising fish oil and medium-chain triglycerides (MCT) and/or omega-3 fatty acids and medium-chain triglycerides (MCT). In some embodiments, the compositions further comprise, e.g., alpha-tocopherol, or one or more fatty acids. Further provided herein are methods of using the compositions, e.g., to provide nutrion, e.g., parenteral nutrition to a subject and/or to treat or prevent certain conditions described herein.
Patent WO-2019118037-A1 (WO)
Title: Schéma d'accélération de transfert de mémoire cache basé sur un agent domestique
Inventor: APTE AMIT P
IPC: G06F12/0817
Filed: 2018-09-19
Abstract: L'invention concerne des systèmes, des appareils et des procédés permettant de mettre en œuvre un mécanisme d'échantillon spéculatif. Un système comprend au moins plusieurs nœuds de traitement, un filtre de sonde et un esclave cohérent. L'esclave cohérent comprend une mémoire cache de sonde précoce permettant de mettre en cache des consultations récentes du filtre de sonde. La mémoire cache de sonde précoce comprend des entrées pour des zones de mémoire, une zone comprenant une pluralité de lignes de mémoire cache. L'esclave cohérent effectue des consultations parallèles sur le filtre de sonde et la mémoire cache de sonde précoce en réponse à la réception d'une demande de mémoire. Une sonde précoce est envoyée à un premier nœud de traitement en réponse à la détermination du fait qu'une consultation de la mémoire cache de sonde précoce atteint une première entrée identifiant le premier nœud de traitement comme un propriétaire d'une première zone ciblée par la demande de mémoire et en réponse à la détermination du fait qu'un indicateur de confiance de la première entrée est supérieur à un seuil.
Patent WO-2019060854-A1 (WO)
Title: Rotating valve assembly
Inventor: BUCKLEY CHRIS
IPC: F04B53/10
Filed: 2018-09-24
Abstract: A valve assembly includes a valve body having a circular perimeter and a thickness and a leg body in communication with the valve body. The leg body includes a base and one or more legs that extend outward from the base. The leg body is detachable from the main valve body to permit interchanging. The valve body includes a seal around the circumference of the valve body. The seal extends upward and beneath the midline. The one or more legs are optionally angled or offset from a vertical plane to permit rotations of the valve assembly within its seat.
Patent WO-2019094124-A1 (WO)
Title: Soudure par ultrasons entre des composants d'un ensemble pompe électrique submersible
Inventor: CAIN SEAN A
IPC: B23K101/10
Filed: 2018-10-03
Abstract: L'invention concerne un ensemble pompe de puits de fond de trou (13) comprenant une pompe (15) et un moteur (21). Le moteur présente un carter de moteur (27) doté d'un adaptateur de tête de moteur (25) sur une extrémité, l'adaptateur de tête de moteur présentant un connecteur fileté (77, 79). Une section d'étanchéité (23) assure l'étanchéité autour d'un arbre du moteur, la section d'étanchéité présentant un adaptateur de section d'étanchéité (26) relié à l'adaptateur de tête de moteur doté du connecteur fileté. L'adaptateur de tête de moteur et le carter de moteur présentent des surfaces extérieures cylindriques (31, 43) et des faces d'extrémité (35, 47) qui se font face, délimitant un joint d'étanchéité entre les faces d'extrémité. Une bande de feuille métallique (55) est soudée autour des surfaces extérieures de l'adaptateur de tête de moteur et du carter de moteur au niveau du joint d'étanchéité, assurant l'étanchéité de l'entrée de fluides de puits dans le joint d'étanchéité.
Patent WO-2019075044-A1 (WO)
Title: Physiological condition information for remote healthcare determination
Inventor: STORMO LONNY
IPC: G16H80/00
Filed: 2018-10-10
Abstract: Devices, systems, and processes are disclosed herein relating to the collection, transmission, and/or use of physiological condition information (e.g., blood glucose information) for a remote healthcare determination. One embodiment includes a physiological condition information system. This system embodiment includes a physiological condition management device and a remote server. The physiological condition management device can be at a first location (e.g., accompanying a patient at the first location) and the remote server can be at a second location that is different from the first location. The physiological condition management device and remote server can be in data communication over a transmission link. The physiological condition management device is configured to collect physiological condition information associated with the patient and send this information over the transmission link to the remote server. Upon receiving the physiological condition information, the remote server is configured to send a data communication to a remote healthcare provider.
Patent WO-2019084243-A1 (WO)
Inventor: ZHU XIAOBO
IPC: C08L75/16
Filed: 2018-10-25
Abstract: L'invention concerne une composition adhésive durcissable par voie actinique, appropriée pour sceller un emballage souple, qui comprend un polymère d'uréthane inerte et un constituant monomère éthyléniquement insaturé choisi parmi au moins un monomère monofonctionnel éthyléniquement insaturé, au moins un monomère multifonctionnel éthyléniquement insaturé et une combinaison correspondante, le constituant monomère éthyléniquement insaturé dispersant le polymère d'uréthane inerte. Les compositions sont appropriées pour former des matériaux d'emballage souples pour des aliments et d'autres matériaux, en particulier des matériaux sensibles. L'invention concerne également des matériaux d'emballage souples et un procédé de préparation d'une composition adhésive durcissable par voie actinique.
Patent WO-2019125612-A1 (WO)
Title: Sélection dynamique de caractéristiques permettant la génération de modèles
Inventor: LEI MING
IPC: G06Q30/02
Filed: 2018-11-02
Abstract: Des modes de réalisation de la présente invention génèrent un modèle de demande d'un produit qui comprend un ensemble de caractéristiques optimisé. Des modes de réalisation reçoivent un historique de ventes pour le produit et reçoivent un ensemble de caractéristiques pertinentes pour le produit et désignent un sous-ensemble des caractéristiques pertinentes en tant que caractéristiques obligatoires. À partir de l'historique de ventes, des modes de réalisation forment un ensemble de données d'apprentissage et un ensemble de données de validation et sélectionnent de manière aléatoire, à partir de l'ensemble de caractéristiques pertinentes, une ou plusieurs caractéristiques optionnelles. Des modes de réalisation comprennent les caractéristiques optionnelles sélectionnées ainsi que les caractéristiques obligatoires afin de créer un ensemble de tests de caractéristiques. Des modes de réalisation entraînent un algorithme à l'aide de l'ensemble de données d'apprentissage et de l'ensemble de tests de caractéristiques afin de générer un algorithme entraîné et de calculer un paramètre d'arrêt précoce à l'aide de l'algorithme entraîné et de l'ensemble de données de validation. Lorsque le paramètre d'arrêt précoce est inférieur à un seuil prédéfini, l'ensemble de tests de caractéristiques est l'ensemble de caractéristiques optimisé.
Patent WO-2019094533-A1 (WO)
Inventor: CHU CHUN
IPC: C07K16/26
Filed: 2018-11-08
Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind angiopoietin-iike protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.
Patent WO-2019099696-A1 (WO)
Title: Vecteurs viraux comprenant des séquences codantes de rdh12 et méthodes de traitement de dystrophies rétiniennes
Inventor: THOMPSON DEBRA A
IPC: C12N15/63
Filed: 2018-11-15
Abstract: L'invention concerne des substances, des méthodes et des utilisations permettant de traiter une affection ophtalmologique telle qu'une amaurose congénitale de Leber par l'administration d'une quantité efficace d'un virus adéno-associé AAV2, de sérotype 5 (AAV 2/5) ou AAV-5 comprenant une séquence codante exprimable codant le RDH12 humain.
Patent WO-2019104169-A1 (WO)
Inventor: PATEL HASMUKH AMBALAL
IPC: A23C9/142
Filed: 2018-11-21
Abstract: L'invention concerne des procédés de purification d'exosomes consistant à utiliser une composition de lactosérum comme source d'exosomes. Les exosomes sont isolés par soumission de la composition de lactosérum à une première ultrafiltration, qui produit un premier perméat et un premier rétentat. Le premier rétentat peut ensuite être soumis à une deuxième ultrafiltration, produisant un deuxième perméat et un deuxième rétentat. Pendant la deuxième ultrafiltration, le premier rétentat peut être traité avec du dioxyde de carbone. Le deuxième rétentat peut ensuite être soumis à une troisième ultrafiltration, produisant un troisième perméat et un troisième rétentat. Le troisième perméat peut ensuite être éventuellement séché pour produire une poudre d'exosomes.
Patent WO-2019108606-A1 (WO)
Inventor: ORTIZ AUBREY
IPC: A61B17/56
Filed: 2018-11-28
Abstract: L'invention concerne divers dispositifs d'accouplement tige à tige ayant des mécanismes de fermeture par tige robustes et des procédés associés, par exemple, pour améliorer la force de verrouillage ou de serrage sur une tige. Un exemple de dispositif d'accouplement peut fournir un mécanisme de fermeture robuste pour des accouplements tige à tige dans lesquelles la course sur la longueur d'une fente de tige est minimale. Le dispositif d'accouplement peut comprendre une mâchoire mobile qui est partiellement disposée à l'intérieur d'un corps de dispositif d'accouplement et configurée pour pivoter ou se déplacer par rapport au corps de dispositif d'accouplement afin de former une fente de tige complètement ou sensiblement fermée autour d'une première tige. La fente de tige fermée peut être formée entre un premier évidement de réception de tige défini dans le corps de dispositif d'accouplement et un premier évidement de réception de tige équivalent défini dans la mâchoire mobile. La force de verrouillage ou de serrage de la mâchoire mobile peut être amplifiée par un avantage mécanique généré par la force exercée pour verrouiller une seconde tige dans une seconde fente de réception de tige du corps de dispositif d'accouplement.
Patent WO-2020131121-A1 (WO)
Title: Modular system for internet of things
Inventor: LUCERO CHRISTOPHER
IPC: H05K7/14
Filed: 2018-12-21
Abstract: In some examples, an Internet of Things (IoT) apparatus including a plurality of boards and one or more connectors to couple IoT modules to one or more of the plurality of boards and to couple the plurality of boards to each other. The connectors include stacking connectors on both sides of at least some of the boards and at least some of the IoT modules to be coupled to the boards. The stacking connectors allow the IoT modules and the boards to be coupled together in a manner that boards and modules cannot be inserted incorrectly.
Patent WO-2019136304-A1 (WO)
Inventor: PERRY JEDD
IPC: B64G1/22
Filed: 2019-01-04
Abstract: In one embodiment, an apparatus is attached to a feature to be deployed on a satellite. The apparatus includes a first material having an impedance, a second material coupled to the first material configured to provide a current or voltage to the first material causing the first material to generate heat based on the impedance after a launch process of a launch vehicle carrying the satellite has completed, and a third material configured to change state at a transition temperature. A release mechanism is coupled to the third material and holds the feature in an undeployed position on the satellite. The heat generated by the second material causes the third material to change state when the transition temperature range is reached and the release mechanism is released from the third material when the third material is in the second state to deploy the feature.
Patent WO-2019140137-A1 (WO)
Title: Compositions and methods of expansion of t cell populations
Inventor: GOOD ZINAIDA
IPC: C07K14/725
Filed: 2019-01-10
Abstract: The present disclosure generally relates to compositions and methods useful for an adoptive cell therapy. Some embodiments of the disclosure relates to methods for producing a population of lymphocytes enriched in T stem cell memory cells (TSCM cells). Further provided are compositions containing a substantially pure population of TSCM cells that are therapeutically effective in treating various cancers, and kits containing such compositions. Methods for treating a subject having or suspected of having a cancer using the compositions and kits as disclosed herein are also provided.
Patent WO-2019140205-A1 (WO)
Title: Methods for forming metal-containing particles in barton reactors and for retrofitting barton reactors
Inventor: KOWALSKI PHILIP MICHAEL
IPC: C01G21/06
Filed: 2019-01-11
Abstract: According to one or more embodiments presently described, metal-containing particles may be formed by a method including forming a molten material from a solid supply material, introducing the molten material into a reaction zone of a Barton reactor, and contacting the molten material with a processing gas in the reaction zone to form solid metal-containing particles comprising solid metallic particles and solid metal oxide particles. The Barton reactor may include a reaction vessel which may include a top cover and sidewalls defining the reaction zone, an agitator, a processing gas inlet, and a product outlet. The molten material may be introduced to the reaction zone in a laminar flow or as atomized molten particles. Less than 99% of the particles may include metal oxide.
Patent WO-2019147808-A1 (WO)
Inventor: Tiene Michael
IPC: G10K11/22
Filed: 2019-01-24
Abstract: Un dispositif de guides d'ondes acoustiques flexible avec une bande unitaire flexible comprenant une pluralité de guides d'ondes acoustiques disposés côte à côte le long d'une longueur de la bande.
Patent WO-2019152943-A1 (WO)
Title: Methods, systems, and media for predicting functions of molecular sequences
Inventor: WOODBURY NEAL W
IPC: G01N33/68
Filed: 2019-02-04
Abstract: Methods and systems for predicting functions of molecular sequences, comprising: generating an array that represents a sequence of molecules; determining a projection of the sequence of molecules, wherein the determining comprises multiplying a representation of the array that represents the sequence of the molecules by a first hidden layer matrix that represents a number of possible sequence dependent functions, wherein the first hidden layer matrix is determined during training of a neural network; and determining a function of the sequence of molecules by applying a plurality of weights to a representation of the projection of the sequence of molecules, wherein the plurality of weights is determined during the training of the neural network.
Patent WO-2019168758-A1 (WO)
Inventor: MCNULTY JOHN
IPC: A47K5/12
Filed: 2019-02-22
Abstract: A dispenser includes a housing, an inverted container disposed in the housing, a outlet nozzle, a pump, a first check valve, and a second check valve. The container holds a fluid. The pump is disposed between the container and the outlet nozzle. The pump includes a pump inlet in fluid communication with the container, a pump outlet in fluid communication with the outlet nozzle, and a pump chamber in fluid communication with the pump inlet and the pump outlet. The pump chamber is movable between an expanded position and a compressed position. The first check valve is disposed between the pump and the outlet nozzle, and the first check valve has a first cracking pressure. The second check valve is disposed between the first check valve and the outlet nozzle, and the second check valve has a second cracking pressure. The second cracking pressure of the second check valve is greater than the first cracking pressure of the first check valve.
Patent WO-2019173376-A1 (WO)
Title: Ipsc-derived cell compositions, and related systems and methods for cartilage repair
Inventor: SMITH ROBIN Y
IPC: A61L27/00
Filed: 2019-03-05
Abstract: Presented herein are personalized compositions comprising iPSCs and/or iPSC-derived cells (cells) and methods of producing personalized compositions suitable for various therapies, including chondrogenesis therapies, to be administered to an individual or a group of individuals. The cells and/or cell lines, and any compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match. The compatible cells are then used to derive "personalized" compositions, wherein the "personalized" compositions comprise one or more cell-secreted molecules suitable for therapy. It is found herein that a composition comprising one or more iPSC-derived MSCs, iPSC-derived chondrocytes, and iPSC-derived chondrons may provide improved treatment efficacy than would be offered by bone marrow-MSCs (BM-MSCs) or compositions comprising BM-MSCs.
Patent WO-2019183084-A1 (WO)
Inventor: SINGH GYANVEER
IPC: H04N21/454
Filed: 2019-03-19
Abstract: Systems and methods for warning a user that media assets associated with another user depict the user with an undesired expression are provided. A plurality of media assets associated with a first user and depicting a second user may be identified. A set of expressions of the second user that the second user has indicated as undesirable may be retrieved. The depictions of the second user in the plurality of media assets and the expressions that the second user has indicated are undesirable may be compared. If it is determined that one or more of the media assets depict the second user with an undesirable expression, a notification may be generated to the second user indicating that one or more media assets of the first user depict the second user with an expression that the second user has indicated as undesirable.
Patent WO-2019195037-A1 (WO)
Title: Bitstream signaling of error mitigation in sub-picture bitstream based viewport dependent video coding
Inventor: WANG YE-KUI
IPC: H04N19/597
Filed: 2019-03-26
Abstract: A video coding mechanism for viewpoint dependent video coding is disclosed. The mechanism includes mapping a spherical video sequence into a plurality of sub-picture video sequences. The mechanism further includes encoding the plurality of sub-picture video sequences as sub-picture bitstreams to support merging of the plurality of sub-picture bitstreams, the encoding ensuring that each sub-picture bitstream is self-referenced and two or more of the sub-picture bitstreams can be merged to generate a single video bitstream using a lightweight bitstream rewriting process that does not involve changing of any block-level coding results. A mergable indication is encoded to indicate that the sub-picture bitstream containing the indication is compatible with a multi-bitstream merge function for reconstruction of the spherical video sequence. A set of the sub-picture bitstreams and the mergable indication are transmitted toward the decoder to support decoding and displaying a virtual reality video viewport.
Patent WO-2019204253-A1 (WO)
Title: Genes, constructs and maize event dp-202216-6
Inventor: CHRISTENSEN HEATHER MARIE
IPC: C12Q1/68
Filed: 2019-04-16
Abstract: The compositions and methods disclosed relate to DNA compositions, plant cells, seeds, plant parts that relate to maize plants with increased grain yield trait. Also provided are assays for detecting the presence of the maize DP-202216-6 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
Patent WO-2019210058-A1 (WO)
Title: Catalyst solvents for carbon nitride
Inventor: MONTROSS CHARLIE
IPC: C09K3/14
Filed: 2019-04-25
Abstract: In one embodiment, a method of producing an sp3 bonded C 3 N 4  product includes contacting a starting material with a catalyst solvent in a reaction vessel, heating the reaction vessel to a temperature of 900° to 2000°C under a pressure of 4 to 8 GPa, melting at least some of the catalyst solvent, and transforming at least some of the sp2 bonded C 3 N 4  into sp3 hybridized C 3 N 4 . The starting material may include sp2 bonded C 3 N 4 . The catalyst solvent may be a solid at room temperature. In one example, the catalyst solvent is a carbo-nitride based catalyst solvent including a first compound having the chemical formula A x B y N z  and a second compound having the chemical formula D q E r C s . In a second example, the catalyst solvent is a metal alloy based catalyst solvent including a compound having the chemical formula G x H y .
Patent WO-2019217258-A1 (WO)
Title: A tasteful natural sweetener and flavor
Inventor: SHI WEIYAO
IPC: C11B9/00
Filed: 2019-05-06
Abstract: The invention describes products, uses thereof, compositions thereof, and methods to prepare products formed from Maillard reaction products from a sugar donor and/or sweet tea extracts, stevia extracts, swingle (mogroside) extracts, one or more sweet tea extract components, one or more steviol glycosides, one or more mogrosides, one or more glycosylated sweet tea glycosides, one or more glycosylated steviol glycosides or one or more glycosylated mogrosides and an amine donor/reactant.
Patent WO-2019217952-A1 (WO)
Title: Nonlinear optical components for all-optical probabilistic graphical model
Inventor: BABAEIAN MASOUD
IPC: G06E1/04
Filed: 2019-05-13
Abstract: A method of multiplying together a series of factors includes representing a multiplication operation in terms of a summation of a series of natural logarithmic functions that undergo exponentiation to represent the multiplication of the factors. An optical signal is generated for each of the factors to be multiplied. Each optical signal has a power or energy level that represents its respective factor. Each of the optical signals is applied to a respective material that undergoes a two-photon absorption process to implement a natural logarithm function. Each optical output signal output by the materials is directed to an optical combiner to obtain a summed optical signal. The summed optical signal is directed to a saturable absorber to implement an exponential function. The power or energy of the resulting optical output signal from the saturable absorber represents the product of the factors to be multiplied.
Patent WO-2019222256-A1 (WO)
Inventor: TROJANOWSKI JAMES
IPC: B23K101/18
Filed: 2019-05-14
Abstract: L'invention concerne des procédés et des systèmes de découpage au laser des composants. Des exemples sont spécifiquement adaptés au découpage au laser de composants relativement grands, par exemple, d'un châssis de véhicule tel qu'un panneau latéral unitaire d'une porte de véhicule. Plusieurs robots peuvent effectuer des opérations de découpage au laser sensiblement simultanément.