baber/WOPTO huggingface dataset:
Patent IE-35810-B1 (IE)
Title: Benzopyrano derivatives and processes for the preparation thereof
Inventor: VILLANI F J
IPC: C07D213/84
Filed: 1971-11-15
Abstract: 1373246 Azaxanthene derivatives SCHERICO Ltd 15 Nov 1971 [16 Nov 1970] 52899/71 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein the ring labelled (N) is a pyridine ring, (in which the N atom may not be in a ring-fusion position), Q is halogen, polyhaloalkyl (C 1-6 ), OH or C 1-6 alkoxy; n is 0, 1 or 2; A is 3- or 4- piperidylidene (possibly NC 1-6 alkyl or -polyhaloalkyl-substituted) or is C 2-4 aminoalkylidene (possibly N-mono- or di- C 1-6 -alkyl-substituted) with at least 2 C atoms between N and the tricyclic nucleus; and W is H(Ia) or OH (Ib) while R is H, or W-R forms a further bond (Ic). In examples, Ia are prepared by hydrogenating Ic; Ib are prepared by reacting the corresponding azaxanthone with RAMgCl or RACl+Na/NH 3 ; and Ic are prepared by (i) heating Ib with polyphosphoric acid or H 2 SO 4 , (ii) cyclizing with polyphosphoric acid a phenoxypyridyl/N-methylpiperidyl ketone or ketimine, (iii) removing the O of a corresponding N-oxide, (iv) decarboxylating a derived carboxylic acid, and (v) (where A is piperidylidene) removing an N-methyl group, replacing an N- attached H atom by Me or CH 2 CF 3 , or reacting the tetrahydropyranylidene analogue (itself made from the tetrahydropyranyl-hydroxy-azaxanthene) with MeNH 2 . Therapeutic compositions having bronchodilator and (in the case of 3-azaxanthenes) CNS activity, comprise compounds of the above formula, and may be administered orally, parenterally or by inhalation.
[GB1373246A]
Patent IE-32544-B1 (IE)
Title: Halocinnamoyl piperidines and morpholines and pharmaceutical compositions containing them
IPC: C07F9/58
Filed: 1968-12-02
Abstract: ANTIPHLOGISTIC AND ANTIPYRETIC CINNAMIC ACID AMIDES G3A- Are new compounds of formula (I): (where R1 is Br or I and R2 is piperidino, 4-hydroxypiperidino or morpholino). Prepared by (a) reacting (II): (where X is OH, NH2, NH(lower alkyl) or N(lower alkyl)2 or a reactive residue, e.g. halogen, alkoxy or acyloxy) with H-R, or a reactive deriv. thereof or (b) olefinating (IV) with (V): (where A is (R3O)2P-CH2- in which R3 is lower alkyl, or (R4)3P=CH- in which R4 is aryl or alkyl), the reaction being carried out in the presence of a base when A is (R3O)2P-CH2-. Use is as antiphlogistics and antipyretics (better than phenylbutazone in kaolin- and carrageenin-oedema tests).
[DE1814625A1]
Patent IE-58117-B1 (IE)
Title: Dialkoxypyridines, process for their preparation, their use and medicaments containing them
IPC: C07D401/12
Filed: 1985-06-14
Abstract: Dialkoxypyridines of formula I <IMAGE> (I) wherein R1 is 1-3C-alkyl which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical and R1' is hydrogen, halo, trifluoromethyl, 1-3C-alkyl, or 1-3C-alkoxy which is optionally completely or predominantly substituted by fluorine, or R1 and R1', together with the oxygen atom to which R1 is bonded, are 1-2C-alkylenedioxy, which is optionally completely or partly substituted by fluorine, or chlorotrifluoroethylenedioxy, R3 is 1-3C-alkoxy, one of R2 and R4 is 1-3C-alkoxy and the other is a hydrogen atom or 1-3C-alkyl and n is 0 or 1, and salts thereof are new compounds with a pronounced protective action on the stomach. Processes for preparing these compounds, medicaments containing them and their use, as well as intermediate compounds and their use for preparing the subject dialkoxypyridines, are disclosed.
[US4758579A]
Patent IE-51365-B1 (IE)
Title: Antibacterial cephalosporins
IPC: C07D501/36
Filed: 1981-07-02
Abstract: Cephalosporines with antibacterial and pharmacokinetic properties of the formula: …… in which… R is hydrogen or lower alkyl of from 1-4 carbon atoms… Y is hydrogen or methoxy,… n is 2-5,… or a pharmaceutically acceptable salt thereof.… As well as a process for their preparation.
Patent IE-50015-B1 (IE)
Title: 3-methyleneazetidine derivatives
IPC: A61P25/24
Filed: 1980-07-17
Abstract: This invention provides a novel class of 3-methyleneazetidines which include diphenylmethyl derivatives such as 1-isopropyl-3-diphenylmethyleneazetidine oxalate:  This illustrated 3-methyleneazetidine compound is characterized by a combination of pharmacological properties which are indicative of utility as a mood elevating therapeutic agent for relieving the symptoms of depression in humans. The illustrated compound exhibits an ED50 (tetrabenazine-induced ptosis) of 2.18 mg/kg in mice.
Patent IE-63548-B1 (IE)
Title: Oral drug delivery formulation and method for preparing same
Inventor: NEWSHAM EDWARD ANTHONY
IPC: A61K47/00
Filed: 1988-05-20
Abstract: Oral drug delivery systems are provided formed of compositions which include one or more hydrocolloids solids, such as gelatin, pectin, and sodium carboxymethyl cellulose, and preferably mixtures thereof, which solids contain less than about 5% by weight moisture and preferably comprise less than about 50% by weight of the total formulation; and an ointment base such as mineral oil containing dispersed polyethylene (Plastibase). Such oral drug delivery compositions may be used to deliver to the oral mucosa active ingredients such as steroids, anti-fungal agents, anti-bacterial agents and the like and do not harden even upon prolonged storage or upon filling into containers.
Patent IE-55769-B1 (IE)
Title: 3-phenoxy-1-azetidinecarboxamides and their use and preparation
IPC: A61P25/08
Filed: 1983-07-15
Abstract: 3-Phenoxy-1-azetidinecarboxamides having the formula wherein R<1> represent hydrogen, fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl or aminocarbonyl having prolonged anticonvulsant activity are disclosed.
Patent IE-39658-B1 (IE)
Title: N-substituted glycinates, a process for their preparation and pharmaceutical compositions containing them
IPC: C07C229/36
Filed: 1974-08-07
Abstract: 1434088 N-substituted glycinates SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 16 Aug 1974 [16 Aug 1973] 38730/73 Heading C2C Novel compounds of Formula I in which R represents a cyclopentyl, cyclohexyl or benzyl radical or a benzyl radical carrying one or more substituents selected from halogen atoms, alkyl and alkoxy radicals each having from 1 to 4 carbon atoms, and methylenedioxy and trifluoromethyl radicals, in the form of racemic mixtures and optical isomers, and acid addition salts, especially physiologically tolerable acid addition salts thereof are prepared by reaction of a compound of formula with a compound of formula Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having anorexigenic activity comprise an above novel compound and a carrier or diluent.
[GB1434088A]
Patent IE-55542-B1 (IE)
Title: Dental implant device
IPC: A61C8/00
Filed: 1984-07-06
Abstract: A dental implant device has a root structure (10) made of a biocompatible, mechanically suitable prosthetic material, a cervical segment (18) projecting above the root structure. made of a biocompatible, nonporous material and having smooth surfaces and together with the root structure forming a member; and a gingival interface (22) made of expanded polytetrafluoroethylene having a porous structureforthe ingrowth of connective tissue, located adjacent to the juncture of the root structure (10) and the cervical segment (18) attached to the member and forming a border around the apical end of the cervical segment. The expanded polytetrafluoroethylene provides for an interlocking between the gingival tissue and the pergingival portion of the dental implant preventing bacterial penetration and infection where the implant extends into the oral cavity.
Patent IE-63537-B1 (IE)
Title: Antirhinoviral (thio)morpholinyl and piperazinyl alkylphenol ethers
Inventor: STOKBROEKX RAYMOND ANTOINE
IPC: C07D237/02
Filed: 1990-05-14
Abstract: (Thio)morpholinyl and piperazinyl alkylphenol ethers of formula <CHEM> X is O, S or NR<5>; n is 1 to 4; R<1> and R<2> are hydrogen, C1-4alkyl or halo; and R<3> is hydrogen, halo, cyano, C1-4alkyloxy, aryl or -COOR<4> with R<4> being hydrogen, C1-4alkyl, arylC1-4alkyl, C3-6cycloalkylC1-4alkyl, C3-5alkenyl, C3-5alkynyl or C1-4alkyloxyC1-4alkyl; or R<3> is a radical of formula <CHEM> the acid addition salts and stereochemically isomeric forms thereof, said compounds having antirhinoviral activity, pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.
Patent IE-69984-B1 (IE)
Title: Angiotensin II receptor blocking imidazoles
Inventor: CARINI DAVID JOHN
IPC: C07D233/64
Filed: 1987-07-10
Abstract: Substituted imidazoles such as <CHEM> are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
Patent IE-58744-B1 (IE)
Title: Coating composition containing dispersed particles of ethyl acrylate copolymer
IPC: C08F2/08
Filed: 1985-07-25
Abstract: A coating composition which is especially suitable for producing decorative coatings upon wood substrates comprises, as at least 51 % by weight of the film-forming material present, a sterically stabilised dispersion in a volatile organic liquid of insoluble vinyl or acrylic polymer particles, the polymer having an extensibility of 50-2000% and being crosslinked to such an extent that it has a gel content of at least 35% by weight.
Patent IE-40242-B1 (IE)
Title: A yoghurt-making machine
IPC: A23C9/12
Filed: 1974-09-24
Abstract: A yoghurt-making machine comprises an enclosure inside which a receptacle containing milk pots is disposed above a basin. The space between the receptacle and basis is partly filled with a fusible material, such as commercial paraffin wax which has a cooling curve exhibiting a solidification plateau at a temperature near to the optimum temperature of yoghurt formation. A heating resistor attached to the basin is immersed in the fusible material which is thereby heated. The basin has a bottom defining with the enclosure a closed chamber completely separated from the fusible material. A temperature-limiting element is connected to the resistor and disposed so as to be responsive only to the air temperature within the chamber and is operable to terminate the heating of the fusible material when the temperature in the chamber is higher than the solidification plateau of the fusible material. The amount of the fusible material is sufficient for its solidification plateau to be maintained during subsequent cooling throughout the duration required for the formation of the yoghurt.
[US4009368A]
Patent IE-63332-B1 (IE)
Title: Water soluble organic ammonium per halides
Inventor: FAVSTRITSKY NICOLAI A
IPC: C07C211/63
Filed: 1989-06-19
Abstract: Water soluble biocidal water treatment perhalides of the formula: where R1 and R2 are independently hydrogen, hydroxyethyl, alkyl, cyclic alkyl, (alpha, omega)-alkyl, alkyl ether, polyether, heterocyclic ring-substituted alkyl, and halogenated alkyl; X is chlorine, bromine or iodine; and only one of R1 and R2 may be hydrogen.
Patent IE-61025-B1 (IE)
Title: Process for alpha-c-alkylation of the 8 acyl groupof mevinolin and analogs thereof
IPC: C07F7/18
Filed: 1988-07-08
Abstract: A process for alkylating the alpha position of the 8-acyl side chain in mevinolin and analogs thereof is disclosed. The process proceeds with a single charge of base and alkyl halide to give products with a pharmaceutically acceptable purity.
Patent IE-40452-B1 (IE)
Title: Method and apparatus for forming impressions in filters
IPC: A24D3/02
Filed: 1974-12-18
Abstract: This invention relates to a method and apparatus for forming cigarette filters, including a means for receiving and holding a plurality of filters and a heated probe which can be moved into contact with the filters to form the filters into a desired configuration.
[US3958498A]
Patent IE-65966-B1 (IE)
Title: Telecommunication networks
Inventor: SOMMERVILLE IAIN DOUGLAS
IPC: H04W12/06
Filed: 1991-10-16
Abstract: In a cellular telephone network, subscribers each have a token (such as a smartcard) by means of which they respectively identify themselves to the network. Each subscriber logs into the network by using his smartcard which inputs a unique identification number (IMSI) into the network. The relationship between each IMSI and the corresponding subscriber's telephone number (MSISDN) is random and stored in a home location register (HLR). When a subscriber activates a mobile using his smartcard, a visitor location register (VLR) at the relevant cell cheks for presence of the IMSI and the corresponding MSISDN. If they are not present, it extracts them from the HLR. When a replacement smartcard is issued to a subscriber, the new IMSI is stored in the HLR in association with the IMSI of the previous smartcard. When the replacement smartcard is first used, the relevant VLR will note its absence and will follow the same routine as specified above - by accessing the HLR. Not only will it thus obtain and store the MISISDN for the subscriber in association with the IMSI of the new smartcard, but this will also activate the HLR to note first use of the replacement smartcard, cancel all reference to the IMSI of the previous smartcard, and inform the administration centre of the network.
Patent IE-66746-B1 (IE)
Title: A moisture-curing one-component polysiloxane composition
Inventor: MEURER WILLI
IPC: C08K5/57
Filed: 1991-10-17
Abstract: This invention relates to one-component silicone systems (herein referred to as 1-C-RTV compounds) which cure rapidly under the effect of moisture with elimination of certain carbonamides, develop good adhesion to many substrates in the process and give vulcanizates that are stable under extreme climatic conditions.
Patent IE-65919-B1 (IE)
Title: Macrolide compounds
Inventor: BOECK LAVERNE DWAINE
IPC: C12N1/20
Filed: 1989-12-18
Abstract: Fermentation product A83543 (1), comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided. <CHEM>  wherein R is H or a group selected from <CHEM>  R<2> is <CHEM>  R<1>, R<3>, R<5> and R<6> are hydrogen or methyl; R4 is methyl or ethyl; or an acid addition salt thereof the compounds when R is other than hydrogen.
Patent IE-69676-B1 (IE)
Title: Process for the synthesis of azines
Inventor: SCHIRMAN JEAN-PIERRE
IPC: C01B21/16
Filed: 1991-11-22
Abstract: Process for the synthesis of azines from aqueous hydrogen peroxide, ammonia and a reactant bearing a carbonyl group, characterised in that this reactant is brought into contact with an amide of a weak acid and the ammonium salt corresponding to this acid and in that the azine obtained is then isolated. 
<??>The invention also relates to processes in which the reaction takes place in the presence of any mixture containing an amide and the azine is then recovered and the remainder of the reaction mixture is treated to regenerate the amide.
Patent IE-64205-B1 (IE)
Title: Muscarinic receptor antagonists
Inventor: MACKENZIE ALEXANDER RODERICK
IPC: A61K31/40
Filed: 1990-12-11
Abstract: PCT No. PCT/EP90/02043 Sec. 371 Date Jun. 12, 1992 Sec. 102(e) Date Jun. 12, 1992 PCT Filed Nov. 29, 1990 PCT Pub. No. WO91/09013 PCT Pub. Date Jun. 21, 1991.Muscarinic receptor antagonists of formula (I), and their pharmaceutically acceptable salts, wherein Y is -CH2-, -(CH2)2-, -CH2O-, -(CH2)2O- or -CH2S-; R is -CH or -CONH2; and R1 is a group of formula (a), where R2 and R3 are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)nOH, halo, trifluoromethyl, cyano, -(CH2)nNR4R5, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), -CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl2, -SO2NH2, -(CH2)nCONR6R7 or -(CH2)nCOO(C1-C4 alkyl); R4 is H or C1-C4 alkyl; R5 is H, C1-C4 alkyl or C1 -C4 alkysulphonyl; R6 and R7 are each independently H or C1-C4 alkyl; and n is 0, 1 or 2. The compounds are particularly useful in treating irritable bowel syndrome.
Patent IE-65721-B1 (IE)
Title: Thrombolytically acting combined preparation
Inventor: DONNER PETER DR
IPC: A61K38/00
Filed: 1990-12-21
Abstract: The invention concerns a preparation with thrombolytic action, consisting of a combination of the non-fibrin-binding form of the thrombolytic agent v-PA and a fibrin-binding plasminogen activator.
Patent IE-69044-B1 (IE)
Title: Thermoplastic molding compounds a process for their production and a process for the production of moldings of ceramic or metal by sintering
Inventor: HUGGINS JOHN
IPC: C08L83/04
Filed: 1992-07-09
Abstract: The invention concerns new thermoplastic moulding compounds for the manufacture of mouldings made of ceramic material or metal from the appropriate ceramic or metal powders. Thermoplastic moulding compounds can be used for instance in injection-moulding, extrusion or hot-pressing processes in which it is necessary for the moulding compound to have temperature-dependent flow characteristics.
Patent LU-102027-B1 (LU)
Title: Intelligent obstacle avoidance method and system of human-robot safe interaction oriented robotic arm
Inventor: LIU GUOLIANG
IPC: G05D1/02
Filed: 2020-09-03
Granted: 2021-03-03
Abstract: The present disclosure provides an intelligent obstacle avoidance method and system of a human-robot safe interaction oriented robotic arm. The robot monitors an identification marker on the obstacle in real time through an identification marker visual positioning method to obtain the position of the obstacle; and the motion state of the obstacle is calculated through a position detection result and a position change of the obstacle, and a corresponding obstacle avoidance strategy is adopted according to the motion state of the obstacle. The present disclosure allows the robotic arm to make different obstacle avoidance strategies for obstacles in different motion states or human-body. Compared with the existing obstacle avoidance methods, the present disclosure gets rid of the limitation of environment modeling, furthermore, the planning speed is fast enough, timely and effective obstacle avoidance strategies can be made for obstacles that suddenly appear in the workspace and dynamic obstacles.
Patent LU-502153-B1 (LU)
Title: Passenger car noise control method
Inventor: LI ZHI
IPC: G10K11/16
Filed: 2022-05-24
Granted: 2022-11-24
Abstract: The invention provides a noise control method for a passenger car, which belongs to the technical field of vibration and noise reduction of automobiles, and comprises the following steps of: carrying out a noise groping test on a target vehicle type to determine a working condition that the noise of the target vehicle type exceeds a standard; and determining a noise transmission path which makes the greatest contribution to the noise of each target point in the vehicle under the working condition that the noise exceeds the standard. ; Accord to that maximum noise transfer path of each noise contribution, and comprehensively considering sound field generated by the sheet metal parts with different main noise contributions at different target point to determine a damping material arrangement scheme of the sheet metal parts with different mate noise contributions. The invention solves the problem of blindness in formulating the damping material arrangement seherns in the existing :attf6raobile acoustic packaging design, and provides an optimal arrangement scheme aiming at specific problem working conditions. It has high reliability, applicability and operability, and can effectively reduce the noise in passenger cars.
Patent NO-303683-B1 (NO)
Inventor: BRETON CLAUDE
IPC: C01D7/38
Filed: 1990-04-23
Abstract: Sodium bicarbonate in the form of ovoid or spherical particles, obtained by crystallisation of sodium bicarbonate from a supersaturated aqueous sodium bicarbonate solution which is circulated through a moving bed of crystals. 
<IMAGE>
Patent NO-307341-B1 (NO)
Inventor: MACLEOD CAROL L
IPC: C12P21/02
Filed: 1992-10-08
Abstract: The present invention provides novel DNA sequences, recombinant DNA (rDNA) molecules, processes for producing novel T-cell proteins expressed in T-cell development, the novel T-cell proteins in substantially pure form and antibodies which bind to the novel proteins. More particularly, it relates to novel DNA sequences expressed in appropriate hosts and the novel T-cell proteins produced in these hosts. The present invention also provides novel transmembrane proteins in substantially pure form, rDNA molecules encoding transmembrane proteins and processes for producing the novel transmembrane proteins. The DNA sequences and recombinant DNA molecules of this invention are characterized in that they are expressed by T lymphoma cells and have at least one of the following characteristics: (1) is expressed in normal thymus, activated spleen cells, or gut associated lymphoid tissue, (2) is expressed in ovarian tissue, normal liver and/or in a stage specific manner in embryonic development and (3) encode novel transmembrane proteins having multiple membrane spanning domains.
Patent NO-304946-B1 (NO)
Inventor: SUZUKI FUMIO
IPC: A61P25/28
Filed: 1993-09-27
Abstract: Disclosed as therapeutic agents for Parkinson's disease are xanthine derivatives of the formula (I): <CHEM>  in which:     R<1> and R<2> each represent methyl or ethyl; R<3> represents hydrogen, C1-C6 straight or branched chain alkyl or C2-C6 straight or branched chain alkenyl or alkynyl; R<4> represents C3-C8 cycloalkyl; a -(CH2)n-R<5> group where n is 0 or an integer of from 1 to 4, and R<5> represents phenyl, naphthyl or a heterocyclic group or a substituted phenyl, naphthyl or heterocyclic group containing from 1-4 substituents selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, amino, mono- or di-(C1-C6) alkylamino, trifluoromethyl, benzyloxy, phenyl, phenoxy or C1-C6 alkoxy substituted by hydroxy, C1-C6 alkoxy, halogen, amino, azide, carboxy or (C1-C6 alkoxy)carbonyl;     or a <CHEM> group where Y<1> and Y<2> each represent hydrogen, halogen, or C1-C6 straight or branched chain alkyl; and Z represents a <CHEM> group in which R<6> represents hydrogen, hydroxy, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain alkoxy, halogen, nitro, or amino, and m represents an integer of from 1 to 4; a phenyl, naphthyl or heterocyclic group or a substituted phenyl, naphthyl or heterocyclic group as defined under R<5>;     and X<1> and X<2> each represent O or S; or a pharmaceutically acceptable salt thereof.