baber/WOPTO huggingface dataset:
Patent DE-69433592-T2 (DE)
Inventor: FLOTTE TERENCE R
IPC: A61K35/76
Filed: 1994-11-03
Granted: 2005-02-10
Abstract: Adeno-associated virus (AAV) vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantifies of such recombinant vectors in amounts that would be clinically useful for human gene therapy application. Stable, helper-free AAV packaging cell lines have been elusive, mainly due to the activities of Rep protein, which down-regulates its own expression and reverses cellular immortalization. This invention provides packaging systems and processes for packaging AAV vectors that efficiently circumvent these problems by replacing the AAV p5 promoter with a heterologous promoter and that allow for substantially increased packaging efficiency.
Patent DE-69433715-T2 (DE)
Inventor: KELLY ROBERT C
IPC: A61K/
Filed: 1994-06-03
Granted: 2005-03-24
Abstract: of formula (I) and their salts are new: R1 = Me, phenyl (opt. substd. by 1-3 substits. from 1-4C alkyl, 1-3C alkoxy or alkylthio, halo, CF3, 2-6C dialkylamino, OH, or nitro), 2-furyl, 2-thienyl, 1- or 2- naphthyl, or 3,4-methylene-dioxyphenyl; R2 = H, NHCO, 2-11C alkanoylamido, benzamido (opt. substd. by 1-3 substits. as phenyl in R1), NHCOCMe=CHMe, NHCOOCMe3, NHCOOCH2Ph, amino, p-toluene-sulphonamido, NHCO(CH2)3COOH, NHCOC6H4-p-SO3H, OH, NHCO-1-adamantyl, NHCOO-3-tetrahydrofuranyl, NHCOO-4-tetrahydropyranyl, NHCOCH2CMe3, NHCOCMe3, 2-11C alkoxycarbamyl, 2-11C alkylureido, phenylureido (opt. substd. as phenyl in R1), 4-9C cycloalkanoylamido, NHCOCMeEt2, NHCOCMe2CH2Cl, NHCOCMe2Et, phthalimido, 1-phenylcyclopentyl-1-carboxamido, 1-methylcyclohexyl-1-carboxamido, NHCSNHCMe3, or NHCONHCMe3; R3 = H, NHCOPh, or NHCOOCMe3; provided that one of R2, R3 is H, but not both; R4 = H, OH, OAc, OCOCH2CCl3, OCOCH2CH2NH3+HCOO-, NHCOPh, NHCOOCMe3, succinyl, glutaryl, or OCO-Z-COR20; Z = CH2CH2, (CH2)3, CH=CH, 1,2-cyclohexane, or 1,2-phenylene; R20 = OH, OM, NR22R23, OR23, SR23, OCH2CONR24R25, OCO(CH2)nNR32R33, OCOCHR"NH2, prolyl, OCOCH=CH2, succinyl-taurine Na or NBu4 salt, 3-succinyl-amido-propane sulphonic acid Na or NBu4 salt, or OCOCH2CH2COOCH2CH2OH; R32, R33 = H or 1-3C alkyl; R" = H, Me, isobutyl, sec-butyl, isopropyl, benzyl, 4-aminobutyl, CH2CH2COOH, or 4-guanidinopropyl; R5 = H or OH; provided that, when R5 = OH, then R4 = H, and when R5 = H, then R4 is not H; R10 = H or Ac; and R17 = H or benzoyl (opt. substd. by 1-3 substits. from azido, cyano, methoxy, or halo. Also claimed are specified oxazolidine carboxylic esters (V), the corresp. acids (VII) and the 7-acyloxy-baccatin esters of these acids; the deacylation of specified taxol and baccatin III derivs. by reaction with hydrazine; and the prepn. of (V) by condensn. of specified serine derivs. with electron-rich benzaldehydes or acetals.
Patent DE-69506380-T2 (DE)
Inventor: PEGG STEPHEN
IPC: A61P29/00
Filed: 1995-02-07
Granted: 1999-05-06
Abstract: The present invention relates to pyrrolidine derivatives, and more particularly to the compound (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide, shown by formula I, and solvates thereof. The present invention also provides pharmaceutical compositions, intermediates and methods of preparation of the compound. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).
Patent DE-69519834-T2 (DE)
Inventor: SKOLNICK MARK H
IPC: C07K14/47
Filed: 1995-08-11
Granted: 2001-04-26
Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers.
Patent DE-69520586-T2 (DE)
Inventor: JOSIC DJURO
IPC: B01J20/32
Filed: 1995-08-22
Granted: 2001-11-15
Abstract: An analytical device comprising a compact porous disc 40 arranged in holding means 35 between two sample distributors 20, 30, two securing means 50, 60, which comprise a reception for inlet and outlet of a sample. (page 14, claim 20) <IMAGE>
Patent DE-69520844-T2 (DE)
Inventor: PROUTY JR WALTER FRANCIS
IPC: A61K38/36
Filed: 1995-01-04
Granted: 2001-11-08
Abstract: The present invention relates to methods to prevent or minimize autodegradation of activated protein C. The invention is best exemplified by performing the processing, purification and/or storage of the activated protein C at low pH, for example at about pH 6.3 to about pH 6.5. Autodegradation of aPC may also be minimized by incubating the aPC in 3 M urea (complete recovery of aPC activity is obtained after the removal of the denaturant) or by incubating the aPC in the presence of extreme salt concentrations. The present invention also comprises aPC formulations which maintain the aPC at low pH, in denaturant, or at extreme salt concentrations.
Patent DE-69521946-T2 (DE)
Inventor: MUNNIX RENE
IPC: C21B13/10
Filed: 1995-06-15
Granted: 2002-04-04
Abstract: A charge (7) in the form of layers (1, M) of finely divided material is deposited on a moving grate (5). The layer (1) consists of iron oxides whilst the layer (M) is a mixt. of a solid carbonaceous redn. agent (2) and a desulphurant (3). The charge is heated, causing at least some of the redn. agent (2) to be converted into gaseous carbon and sulphur cpds. The iron oxides of the layer (1) are reduced by means of at least some of the CO present in the gaseous carbon cpds. At least some of the sulphur present in the gaseous sulphur cpds. is eliminated by means of the desulphurant, after which the reduced iron oxide material is sepd. from the rest of the charge. <IMAGE>
Patent DE-69522417-T2 (DE)
Inventor: RICHTER E
IPC: G01N1/34
Filed: 1995-05-31
Granted: 2002-05-29
Abstract: Methods for the solvent extraction of organic analytes from a sample are provided. An organic solvent system is used to extract analytes under elevated temperatures and pressures above 100 psi but below supercritical conditions in short times and with low amounts of solvent. The extracted organic analytes are then removed by flowing a purge fluid through the extraction cell, the cell being maintained at a constant volume throughout the extraction and purging, afterwards the analytes being analyzed.
Patent DE-69524591-T2 (DE)
Inventor: BLANCHE PAUL
IPC: B01D39/10
Filed: 1995-06-16
Granted: 2002-05-23
Abstract: PCT No. PCT/AU95/00351 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Jun. 16, 1995 PCT Pub. No. WO95/35145 PCT Pub. Date Dec. 28, 1995An apparatus and method for separating material which includes solid and/or particulate matter from flowing liquid and/or gas. The apparatus includes a separation panel positioned in a fluid flow path, and the separation panel is housed in a separation chamber. Fluid can be introduced into the separation chamber by an inlet to establish a circular flow of the fluid within a confine of the separation panel, so material entrained in the fluid is trapped within the confine of the separation panel. The separation panel, separation chamber and inlet can be dimensioned and disposed such that as the apparatus operates, the flow of the fluid outside the separation panel is in a direction opposite to a direction of the flow of the fluid within the separation panel. The separation panel can include plural deflection means for deflecting material entrained in the fluid away from the openings, and the deflection means are generally opposed to a direction of the flow of the fluid, each opening having one of the deflection means associated therewith.
Patent DE-69526212-T2 (DE)
Inventor: DALLA BETTA A
IPC: F23D11/40
Filed: 1995-02-28
Granted: 2004-03-25
Abstract: The invention is an improved catalyst structure and its use in highly exothermic processes like catalyst combustion. This improved catalyst structure employed integral heat exchange in an array of longitudinally disposed, adjacent reaction passage-ways or channels, which are either catalyst-coated (14) or catalyst-free (16), wherein the configuration of the catalyst-coated channels (14) differ from the non-catalyst channels (16) such that, when applied in exothermic reaction processes, such as catalyst combustion, the desired reaction is promoted in the catalytic channels (14) and substantially limited in the non-catalytic channels (16). The invention further comprises an improved reaction system and process for combustion of a fuel wherein catalytic combustion using a catalyst structure employing integral heat exchange, preferably the improved structures of the invention, affords a partially-combusted, gaseous product which is passed to a homogeneous combustion zone where complete combustion is promoted by means of a flameholder.
Patent DE-69606105-T2 (DE)
Inventor: PAJONK GERARD
IPC: C01B33/158
Filed: 1996-07-02
Granted: 2000-08-10
Abstract: Prepn. of monolithic silica aerogel comprises hydrolysing and polycondensing a mixt., contg. organic silicon and an organic solvent in an acidic medium to obtain a transparent gel substituting the organic solvent with liq. carbon dioxide and then removing the carbon dioxide under supercritical conditions where the organic solvent is ethylacetoacetate. Also claimed is a silica aerogel prepd. by the above process.
Patent DE-69608959-T2 (DE)
Inventor: PRIEELS JEAN-PAUL
IPC: A61K9/127
Filed: 1996-04-01
Granted: 2000-11-16
Abstract: A novel vaccine is presented for the prevention of Chlamydia infections utilising the outer membrane protein and two immunostimulants, 3D-MPL and QS21.
Patent DE-69619837-T2 (DE)
Inventor: TATAREK RICHARD
IPC: A61M16/20
Filed: 1996-10-04
Granted: 2002-06-27
Abstract: An adjustable gas flow regulator device primarily for use in medical care, said device comprising a two-part body (8/25) having a high pressure gas inlet connector (1) and a gas outlet connector (16) mounted thereon. Mounted within the body is a conventional regulator comprising a piston (9) axially movable in a stepped bore (46/47). Mounted between the output of the regulator and the outer connector (16) is a flow selector device comprising a flow selecting member (13) rotatable by means of a knob (31). The flow selecting member (13) is formed with a plurality of radially extending bores (54) in the outer part of each of which is fitted a setting plug which may be externally adjustable by a tool (not shown). The inner part of each bore forms part of the route by which gas passes to the outer connector and the flow of gas through each such inner part can thus be adjusted by means of the setting plug so that, at each respective angular position of knob (31), a different flow setting can be obtained, as necessary.
Patent DE-69624365-T2 (DE)
Inventor: OSHIMA MASAHIRO
IPC: A61K38/00
Filed: 1996-07-19
Granted: 2003-06-26
Abstract: Compounds represented by the general formula (I) wherein n represents 1 or 2; R<1> represents, for example, a C1-C10 alkyl group which may be substituted with a C3-C10 cycloalkyl group or carboxyl group; R<2> represents hydrogen atom, a C1-C10 alkyl group or other; and R<3> represents amino group or amidino group, whose example include trans-4-amino-Ä(S)-N-Ä(S)-2-propoxycarbonylamino-3-isopropylthio-3-met hyl-butanoylÜprolylÜaminomethylcyclohexane The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants. <CHEM>
Patent DE-69629341-T2 (DE)
Inventor: IKUINA YOJI
IPC: C07D487/04
Filed: 1996-03-07
Granted: 2004-06-09
Abstract: A pyrrolocarbazole derivative and a pharmaceutically acceptable salt thereof having the following formula (I): <CHEM> wherein R<1> is lower alkyl or aralkyl; R<2> is hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, or substituted or unsubstituted aralkyl; R<3>, R<4>, R<5>, R<6> and R<7> may be the same or different, and are hydrogen, halogen, nitro, substituted or unsubstituted lower alkanoyl, NR<9>R<10>, or OR<11>; R<8> is hydrogen or is combined with R<3> to form -CONR<12>-; and when R<1> is benzyl; R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> are not simultaneously hydrogen. A compound of the present invention stimulates platelet production and is useful for treatment of thrombocytopenia.
Patent DE-69636870-T2 (DE)
Inventor: KEATING T
IPC: C12N15/09
Filed: 1996-12-20
Granted: 2007-11-08
Abstract: One aspect of the invention relates to the identification of the molecular basis of long QT syndrome. More specifically, the invention has identified that mutated KVLQT1 causes long QT syndrome. The analysis of this gene will provide an early diagnosis of subjects with long QT syndrome. The diagnostic methods comprise analyzing the nucleic acid sequence of the KVLQT1 gene of an individual to be tested and comparing them with the nucleic acid sequence of the native, non-variant gene. Alternatively, the amino acid sequence of KVLQT1 may be analyzed for mutations which cause long QT syndrome. Presymptomatic diagnosis of long QT syndrome will enable practitioners to treat this disorder using existing medical therapy. A second aspect of the invention relates to the realization that KVLQT1 coassembles with minK to form a cardiac potassium channel.; This allows one to assay for drugs which interact with this channel to identify new drugs which are useful for treating or preventing long QT.
Patent DE-69702389-T2 (DE)
Inventor: TAUB LAWRENCE
IPC: A61F5/44
Filed: 1997-03-13
Granted: 2000-11-02
Abstract: A method of folding and handling a web of material in a continuous manufacturing operation is disclosed. The method can be used during the process of making disposable absorbent articles, such as sanitary napkins and the like which have side flaps. During the method, a discontinuous portion (or tab) defined by the distal edge of the web of flap material is held stationary and the continuous portion (or continuous ribbon) of the web of flap material is folded.
Patent DE-69705124-T2 (DE)
Inventor: ROSS J
IPC: G03F7/00
Filed: 1997-10-07
Granted: 2001-09-27
Abstract: PCT No. PCT/US97/18173 Sec. 371 Date Feb. 2, 1998 Sec. 102(e) Date Feb. 2, 1998 PCT Filed Oct. 7, 1997Printing of a pattern from a die to a surface is performed by immersing the die in a bath of liquid print material with the die surface facing upward, then either lowering the bath liquid level or raising the die to expose the die surface wet with liquid print material, and contacting the surface to be printed with the wet die surface.
Patent DE-69714935-T2 (DE)
Inventor: DELAISSE GUY
IPC: F01C17/00
Filed: 1997-03-18
Granted: 2003-05-28
Abstract: PCT No. PCT/FR97/00479 Sec. 371 Date Nov. 18, 1997 Sec. 102(e) Date Nov. 18, 1997 PCT Filed Mar. 18, 1997 PCT Pub. No. WO97/36107 PCT Pub. Date Oct. 3, 1997An airtight rotating driving device with eccentricity, especially for volumetric pump, the device including a bent shaft (1) presenting an input axis (5) and an output axis (10) parallel and off-centered in such a way as to carry out an orbital circular movement, and an airtight and non-rotatable sleeve (14) surrounding the shaft and comprising two metallic bellows (19, 20) linked by a guiding ring (21) mounted longitudinally in a sliding relation on the sloped intermediate section (17) of the shaft. The device converts a rotating movement into an orbital circular movement with an absolute airtightness.
Patent DE-69715236-T2 (DE)
Inventor: HARALDSSON ULF
IPC: D21F9/00
Filed: 1997-05-29
Granted: 2003-05-22
Abstract: A multilayer headbox for a papermaking machine which comprises a slice chamber having an upstream inlet and a downstream outlet. A tube bank comprising a plurality of straight tubes is located upstream of the slice chamber. In the slice chamber, at least one machine-wide separator vane is subdividing the slice chamber for the production of multilayered fibrous webs. The separator vane may be a tapered glass fiber reinforced epoxy resin vane or composed of an upstream steel section of constant thickness and a downstream tapered section of glass fiber reinforced epoxy resin. The separator vane has a stiffness, which for at least 70 % of its length is higher than the stiffness of a 1 mm thick reference sheet of a material having a modulus of elasticity of 2100 MPa. In the slice chamber, there is also a plurality of machine-wide turbulence generating elements.
Patent DE-69717130-T2 (DE)
Inventor: SULTAN BERNT-AKE
IPC: C08F210/02
Filed: 1997-09-16
Granted: 2003-10-09
Abstract: The present invention relates to a flame retardant composition comprising (A) a polymer which includes a copolymer of ethylene and at least one other comonomer including a vinyl unsaturated polybishydrocarbylsiloxane; and (B) an inorganic filler comprising at least one member selected from the group consisting of oxides, hydroxides and carbonates of aluminium, magnesium, calcium and barium. It also relates to a cable or wire comprising such a composition.
Patent DE-69727969-T2 (DE)
Inventor: LYKKE KIRSTEN
IPC: C08J7/048
Filed: 1997-04-08
Granted: 2004-07-22
Abstract: PCT No. PCT/DK97/00149 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 8, 1997 PCT Pub. No. WO97/38853 PCT Pub. Date Oct. 23, 1997A multilayered packaging material, in particular for flexible packagings, comprising when seen from the outer face to the inner face an outer, substantially transparent film (1) having a reverse print (2) on its inwardly facing surface; an intermediate layer (3, 4) connected to the printed surface of the outer film (1) and applied in fluid form to the inner, printed surface of the outer film (1); a metallization layer (5) connected to the inner face of the gas barrier layer (3) and an inner sealing medium layer (7), preferably in form of a polyolefine.
Patent DE-69735845-T2 (DE)
Inventor: YAMAUCHI TSUYOSHI
IPC: C07C401/00
Filed: 1997-06-16
Granted: 2006-12-28
Abstract: The present invention provides crystals of the compound represented by formula (II):
Patent DE-69806513-T2 (DE)
Inventor: WOODWARD GARY
IPC: C07F9/6571
Filed: 1998-12-24
Granted: 2003-03-20
Abstract: A method for the preparation of alkene phosphonic acids and salts thereof, such as VDPA (vinylidene diphosphonic acid) is disclosed. The products can be produced in a stable, substantially pure form and in high yield. The method includes the azeotropic removal of water from salts of alpha-hydroxy-alkane diphosphonic acid dimer or corresponding acids thereof, and the pyrolysis of the dehydrated reactant at a temperature of from 170° C. to 300° C. There may be included a step to convert anhydrides which have been formed during the pyrolysis. The method may include the use of heat transfer agents and/or bases, and may be carried out at elevated or reduced pressure.
Patent DE-69807258-T2 (DE)
Inventor: GRIFFIOEN WILLEM
IPC: G02B6/44
Filed: 1998-11-25
Granted: 2003-04-10
Abstract: A cable comprises a cable body (1) provided with a tubular cavity (2) for including a stack (4) having a number of fibre ribbons (5), and with a preferred bending plane (X-X), e.g. through two strength elements (3) located in the cable body on either side of the cavity (2). The cavity has a mainly rectangular cross section and is provided with a pair of opposite sidewalls (2.1, 2.2), at any rate substantially, parallel to the preferred bending plane (X-X). The stack also comprises a spacer (6), included in such a manner that the stack fills the tubular cavity with some play, and the pair of opposite sidewalls provide upper and lower bounds of the stack. The said sidewalls preferably have a slight transverse convexity. The cable may be manufactured complete. The cable may also be completed after prior empty installation of the cable body. The cable permits very high fibre densities and allows for upgrading.
Patent DE-69810974-T2 (DE)
Inventor: WINTER WILLIAM
IPC: E04G13/00
Filed: 1998-03-17
Granted: 2003-11-27
Abstract: There is disclosed a one piece sacrificial shutter comprising a folded section of fluted or corrugated material (10). <IMAGE>
Patent DE-69819139-T2 (DE)
Inventor: RENDERS JOSEPH
IPC: F25B43/00
Filed: 1998-03-02
Granted: 2004-06-17
Abstract: A device for recovering and separating impurities from the cooling fluid of a conditioning system comprises: a cylindrical container provided at its top with an inlet for the fluid/impurities mixture and with an outlet for the fluid and at its bottom with an outlet for the impurities, with a coil positioned inside the container and provided with an inlet and with an outlet to/from the container, a metal cylinder secured within the container and provided with an inlet and with an outlet, a first duct comprising a compressor for the connection of the upper outlet of the container with the inlet of the inner cylinder, a second duct comprising a condenser for the connection of the outlet of the coil with an external collection tank, a third duct for the connection of the outlet of the inner cylinder with the inlet of the coil.
Patent DE-69831913-T2 (DE)
Inventor: HAALAND PERRY D
IPC: C12M1/00
Filed: 1998-05-22
Granted: 2006-07-13
Abstract: The quantity of a nucleic acid sequence in a sample is determined by measuring, during a time interval, related indicia in amplified calibration and test samples. Points during this interval at which the indicia in the calibration samples equal first and second cut-off levels are determined. Using a statistical criterion it is decided which of the two sets of points represents the known quantities of the sequence in the calibration samples. From this selection the quantity in the test sample is determined. Also claimed are: (1) a computer readable program for performing the determinations above; and (2) apparatus for determining a quantity of a nucleic acid sequence in a test sample by measuring the indicia and a device storing a computer program as above.
Patent DE-69837770-T2 (DE)
Inventor: DVAERSAETER GUDMUND
IPC: A61F5/44
Filed: 1998-12-15
Granted: 2008-01-31
Abstract: Rectal insertion device (1) for treating disorders of the digestive tract of a human or animal body such as colic comprising an elongate shaft (3) which is insertable into the anal canal of the human or animal body and a receptacle (12) for collecting feces discharged when the elongate shaft is inserted into the anal canal.