baber/WOPTO huggingface dataset:
Patent NZ-500078-A (NZ)
Title: Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals
Inventor: WELLS JAMES A
IPC: C12N15/02
Filed: 1998-04-03
Abstract: Humanized and variant anti-VEGF antibodies that bind human vascular endothelial growth factor with a Kd value of no more than 1x10-8 are provided. The anti-VEGF antibodies inhibit VEGF-induced proliferation of endothelial cells in vitro, and inhibit tumour growth in vivo.  The antibodies may be used in the treatment of cancer and retinal disorders.
Patent NZ-504669-A (NZ)
Title: Virulence-associated nucleic acid sequences and uses in identification of anti-virulence agents
Inventor: AUSUBEL FREDERICK
IPC: A61P31/04
Filed: 1998-11-25
Abstract: Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques.  Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds
Patent NZ-506437-A (NZ)
Title: Tablets containing cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents
Inventor: LENAERTS VINCENT
IPC: A61K31/137
Filed: 1999-02-24
Abstract: A  solid controlled release oral pharmaceutical dosage unit in the form of a tablet comprises a)  a  blend of 0.01-80% by weight of the tablet  of  a  dry powder of a pharmaceutical product, and b) 20-99.99% by weight of the tablet of a dry powder of high amylose starch wherein  the  dosage  unit is resistant  to  degradation  by amylase. The  high amylose starch comprises a mixture of from  10-60% by  weight of amylopectin and from 40-90% amylose.  The high amylose  starch  has  been covalently  cross-linked  with  a covalent  cross-linking agent wherein the cross-linking  has been  carried  out  with from 0.1 g to 30  grams  of  cross- linking agent per 100 g of the high amylose starch  A solid controlled release pharmaceutical dosage unit in the form of a tablet comprises: a) a pharmaceutical product; b)  high  amylose  starch, wherein the high  amylose  starch comprises 10-60% by weight amylopectin and 40-90% by  weight amylose; and c) a polysaccharide or a polyol. The high amylose starch and the polysaccharide or the polyol are   covalently  co-cross-linked  with  a  covalent  cross- linking  agent  and the cross-linking is  carried  out  with from  0.1 g to 30 g of cross-linking agent per 100 g of high amylose starch. The  cross-linked  high  amylose  starch  having  functional groups is prepared by: a)  reacting high amylose starch with a cross-linking  agent cross-linked  a  concentration of 0.1 g to 40  g  of  cross- linking  agent  per 100 g of high amylose starch  to  afford cross-linked amylose; and b)  reacting  the cross-linked high amylose  starch  with  a functional group-attaching reagent at a concentration of  75 g  to 250 g of functional group-attaching reagent per 100  g of  cross-linked amylose to afford the cross-linked  amylose having functional groups. The  functional  group attaching reagent is monochloroacetic acid and chloroethylamine hydrochloride.
Patent NZ-506515-A (NZ)
Title: COX-2 inhibitor (4-[5-(4-chlorophenyl)-3(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) for treating neoplasia
Inventor: SEIBERT KAREN
IPC: A61K31/4164
Filed: 1997-10-14
Abstract: The compound of formula II is useful in preparing a medicament for the treatment of a neoplasia. R4 is lower haloalkyl, R5 is hydrido and R6 is phenyl optionally substituted with radicals selected from the group consisting of halo, lower alkylthio, lower alkylsulfonyl, cyano, nitro, lower haloalkyl, lower alkyl, hydroxyl, lower alkenyl, lower hydroxyalkyl, carboxyl, lower cycloalkyl, lower alkylamino, lower dialkylamino, lower alkoxycarbonyl, aminocarbonyl, lower alkoxy, lower haloalkoxy, sulfamyl, five or six membered heterocyclic and amino.
Patent NZ-513470-A (NZ)
Title: Device for deployment into an interior body using expandable bodies attached to first and second catheter tubes
Inventor: REILEY MARK A
IPC: A61B19/00
Filed: 1998-06-01
Abstract: A device for deployment into an interior body region comprising a first catheter tube having a distal end, the being formed from a first material, a second catheter tube extending beyond the distal end, the second catheter tube being formed from a second material which is more compliant than the first material, and a structure carried by the first and second catheter tubes comprising a body adapted to assume a collapsed geometry for deployment into the interior body region and an expanded geometry for use within the interior body region, the body including a first end region secured to the first catheter tube and second end region secured to the second catheter tube, the body being formed from a material more compliant than the first material.
Patent NZ-516262-A (NZ)
Title: Gelled nutritional composition and process
Inventor: FUCHS EILEEN C
IPC: A23L9/10
Filed: 2000-07-05
Abstract: A gelled nutritional composition comprising a protein source including gelled whey protein, a carbohydrate source, minerals, and vitamins. The protein source provides 10% to 25% of the energy of the composition and the carbohydrate source provides 60% to 95% of the energy of the composition. Also described is a method of providing nutrition to a patient suffering from dysphagia, the method comprising administering to the patient a gelled nutritional composition which contains a protein source including gelled whey protein, a carbohydrate source, minerals, and vitamins.
Patent NZ-517314-A (NZ)
Title: Bone screw
Inventor: REYNDERS PIET
IPC: A61B17/86
Filed: 1999-09-08
Abstract: A bone screw that is able to be screwed further into the bone even after surrounding bone cement has hardened has a jacket surface 5 with an external thread 6 and a bore 7 coaxial to the longitudinal axis 3 and open toward the head 1 and which is connected to the jacket surface via at least one channel extending transversely to the longitudinal axis and opening to the outside of the jacket to form at least one perforation 9 in the jacket surface. The bore is closed towards the screw tip 4. This configuration allows bone cement to be introduced into the surrounding bone in such a way that an artificial, coaxial bed of cement forms for the bed of the bone screw. As the bed of cement only contacts the screw along the sides and not at the tip, the screw can be tightened further in the axial direction even after the cement has hardened.
Patent NZ-518572-A (NZ)
Title: Process for reducing sticky contaminants in stock systems containing waste paper and in coated broke
Inventor: KOHLER ACHIM
IPC: D21C5/02
Filed: 2001-01-17
Abstract: A process for reducing sticky contaminants with a finely divided composition (microstickies) in the preparation of stock systems containing waste paper and of coated broke and their reuse in the manufacture of papers is disclosed, wherein, after mechanical preparation has been carried out and, if necessary, coarse sticky constituents (macrostickies) have been separated, the stock system has added to it at least one water-soluble organic polyvinyl alcohol or a mixture of various water-soluble polyvinyl alcohols, and at least one bentonite or a mixture of different bentonites.
Patent NZ-519120-A (NZ)
Title: N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]- carboxamide derivatives useful as inhibitors of cyclin dependent kinases
Inventor: MISRA RAJ N
IPC: A61K/
Filed: 2000-12-07
Abstract: A N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]- carboxamide derivative or an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof has the formula (I) wherein: R is alkyl; R1 is hydrogen or alkyl; X is NR2 or CHNR2R3; R2 and R3 are independently hydrogen or optionally substituted alkyl or cycloalkyl and n is 0 to 3. The compounds are useful for modulating apoptosis or for inhibiting protein kinases, or for treating cyclin dependent kinase dependent diseases, cancer, inflammation, inflammatory bowel disease, transplantation rejection, arthritis or for treating chemotherapy induced alopecia, thrombocytopenia, leukopenia or mucocitis
Patent NZ-522341-A (NZ)
Title: Method for inducing viral resistance in plants
Inventor: KOHLE HARALD
IPC: A01N37/36
Filed: 2001-04-30
Abstract: Disclosed herein is a method for inducing viral resistance in plants, wherein the plants, the soil or the seeds are treated with an effective quantity of a compound of formula (I), which is absorbed by the plants or seeds, wherein: X represents halogen C1-C4 alkyl or trifluoromethyl; m is equal to 0 or 1; Q represents C(=CH-CH3)-COOCH3, C(=CH-OCH3)-COOCH3, C(=CH-OCH3)-CONHCH3, C(=N-OCH3)-COOCH3, C(=N-OCH3)-CONHCH3 or N(-OCH3)- COOCH3; A represents -O-B, -CH2O-B, -OCH2-B, -CH=CH-B, -C=C-B, -CH2O-N=C(R1)-B or -CH2O-N=C)R1)-C(R2)=N-OR3, whereby B represents optionally substituted phenyl, naphthyl, 5-member or 6-member hetaryl or 5-member or 6-member heterocyclyl, containing one to three N atoms and/or one O or S atom or one or two O and/or S atoms; R1 represents hydrogen, cyano, alkyl, alkyl halide, cycloalkyl, alkoxy; R2 represents optionally substituted phenyl, phenylcarbonyl, phenylsulfonyl, 5-member or 6-member hetaryl, 5-member or 6-member hetaryl carbonyl or 5-member or 6-member hetaryl sulfonyl, or alkyl, cycloalkyl, alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, alkylsulfonyl or C(=NOR alpha )-OR beta; and R3 represents hydrogen and optionally substituted alkyl, alkenyl and alkynyl.
Patent NZ-522534-A (NZ)
Title: Expandable cross-linked polymeric microparticle compositions and method for recovering hydrocarbon fluids from a subterranean reservoir
Inventor: CHANG KIN-TAI
IPC: C09K8/512
Filed: 2001-05-23
Abstract: A composition comprising expandable cross linked polymeric microparticles having an unexpanded volume average particle size diameter of from about 0.05 to about 10 microns and a cross linking agent content of from about 9,000 to about 200,000 ppm of labile cross linkers and from 0 to about 300 ppm of non-labile cross linkers and the use of the composition for modifying the permeability of subterranean formations and increasing the mobilization and/or recovery rate of hydrocarbon fluids present in the formations is disclosed.
Patent NZ-522841-A (NZ)
Title: Surgically implantable matrix with a viral vector dried onto it for controlled release of recombinant parvovirus vectors
Inventor: RABINOWITZ JOSEPH E
IPC: A61P31/04
Filed: 2001-06-01
Abstract: A method of delivering a recombinant parvovirus vector that comprises a heterologous nucleic acid to a cell comprises contacting (when not present in a human) with a dried recombinant parvovirus vector on a surgically implantable matrix. A recombinant adeno-associated virus ( rAAV ) vector comprising a heterologous nucleic acid can be stored by drying the vector prior to storage at room temperature or onto a surgically implantable matrix prior to the storage. A surgically implantable matrix with a recombinant parvovirus vector dried onto the matrix can be used for treating a disease via gene therapy. Preferably the vector is a recombinant adenovirus vector (rAVV) and the matrix is an implantable device, suture material, catgut, PTFE, a tissue scaffold or a bone graft substitute.
Patent NZ-524043-A (NZ)
Title: Inhibitors of alpha4 mediated cell adhesion
Inventor: KAWAGUCHI TAKAYUKI
IPC: A61K31/165
Filed: 2001-08-27
Abstract: Disclosed are phenylalanine derivatives of formula [1], wherein: X1 is a halogen, X2 is a halogen, Q is a -CH2- or -(CH2)2- group, Y is alkyl, and CO2R is a carboxyl group or an alkoxycarbonyl group. The derivatives are used in the manufacture of medicaments for the treatment of disorders mediated by alpha 4 mediated cell adhesion.
Patent NZ-524195-A (NZ)
Title: Ink cartridge using a negative pressure generating mechanism and method of regulating fluid flow
Inventor: MIYAZAWA HISASHI
IPC: B41J2/175
Filed: 2003-02-14
Abstract: An ink cartridge comprises an ink storage chamber, an ink supply port that is in fluid communication with the ink storage chamber through an ink flow path, a negative pressure generating mechanism which selectively blocks the ink flow path and opens as a consequence of consumption of ink, the negative pressure generating mechanism including an ink supply flow path forming member disposed between the ink storage chamber and the ink supply port, and an elastic member disposed in the ink supply flow path forming member, wherein the elastic member is moved to open the opening portion of the ink flow path when the pressure in the ink supply port decreases to not more than a predetermined value to thereby open the ink flow path and allow the supply of ink to the ink supply port. A method of regulating the fluid flow is also disclosed.
Patent NZ-525069-A (NZ)
Title: Cyclopeptides of VEGF and methods for preparing same and their use as angiogenesis inhibitor or activator
Inventor: BETZ NATACHA
IPC: A61K47/34
Filed: 2001-10-02
Abstract: Cyclopeptides selected from: P11: cylco(DPhe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) SEQ ID NO:5, P16: cylco(Arg-Ile-Lys-Pro-His-Gln-Gly) SEQ ID NO:8, P17: cylco(Pro-Arg-Ile-Lys-Pro-His-Gln-Gly) SEQ ID NO:9, P19: cylco(Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) SEQ ID NO:10, P20: cylco(DPhe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly) SEQ ID NO:11, P23: cylco(DPhe-Pro-Arg-Ile-Lys-Pro-His-Gln) SEQ ID NO:13, P24: cylco(Gly-Arg-Ile-Lys-Pro-His) SEQ ID NO:25, and P11 where DPhe is replaced by DTyr and P20 where DPhe is replaced by DTyr are described. Pharmaceutical composition for inhibiting angiogenesis comprising the cyclopeptides, systems comprising the cyclopeptide covalently bound to a support and methods for preparing the system are described.
Patent NZ-526814-A (NZ)
Title: Sodium-channel alpha1-subunit and their polypeptides and their treatment of generalised epilepsy with febrile seizures plus
Inventor: WALLACE ROBYN HEATHER
IPC: A61P21/04
Filed: 2001-12-20
Abstract: An isolated DNA molecule encodes a mutant sodium channel alpha-1 subunit (SCN1A). The mutation results in the replacement of an isoleucine residue at amino acid position 1656 of the alpha-1 subunit. The mutation event disrupts the functioning of an assembled sodium channel so as to produce an epilepsy phenotype. Polypeptide, antibodies, methods and uses for treating and diagnosing epilepsy are also described.
Patent NZ-530411-A (NZ)
Title: Slicing machine for food in slab form
Inventor: AGNEW MICHAEL WILLIAM
IPC: A21C15/04
Filed: 2003-12-24
Abstract: A baked product slicing machine which includes a first table having a first work surface and a second table having a second work surface which is oriented at right angles to the first work surface. A first product pusher is associated with the first work surface and adapted to have longitudinal reciprocal movement in relation to the first work surface, said reciprocal movement being towards and away from said second work surface a second product pusher associated with the second work surface and adapted to have longitudinal reciprocal movement in relation to the second work surface with means to reciprocate the first product pusher and the second product pusher. A first set of spaced apart knives associated with the first table and a second set of spaced apart knives associated with the second table with each knife in a set being located parallel with its contiguous knife; and each product pusher has a leading edge adapted to contact a slab of baked product to be cut, the said leading edge of each product pusher including a plurality of vertical slits which will register with the knives to allow the knives to enter into the slits of the product pusher, wherein said knives are oriented such that as the slab passes through the knives, the knives exert downward pressure on the slab.
Patent NZ-532254-A (NZ)
Title: Kiwifruit extract and a method for producing powdered kiwifruit extract
Inventor: GAO YI-HUAI
IPC: A23L19/00
Filed: 2004-04-08
Abstract: A method for producing a powdered kiwifruit extract is disclosed, wherein the method comprises the steps of: (a) separation of kiwifruit pericarp and pulp, (b) separation of kiwifruit seed and pulp, (c) physical and enzyme treatments on the separated pericarp, pulp and seeds, and (d) drying of the extract, wherein the enzyme may be pectinase, pectatelyase or pepsin. A quantitative analysis of the powdered kiwifruit extract describing the amount of different components in the extract is also disclosed.
Patent NZ-532996-A (NZ)
Title: 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-carboxamide derivatives, their preparation and therapeutic use
Inventor: BURNIER PHILIPPE
IPC: A61P19/02
Filed: 2002-11-20
Abstract: 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-carboxamide derivative compounds of formula (I) are disclosed, wherein: X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3, represent each, independently of each other, a hydrogen atom or a (C1-C4)alkyl group, or R2 and R3 form, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C1-C4)alkyl, (C1-C4)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. Also disclosed are pharmaceutical compositions containing the compound of formula (I), methods for preparing same and synthesis intermediates thereof.
Patent NZ-534373-A (NZ)
Title: A coater apparatus, for coating moving web, with fixed and movable lips
Inventor: GHELLI LUCA
IPC: B05B15/02
Filed: 2003-01-24
Abstract: A coater apparatus (10) is disclosed for applying coating material onto a moving web. The apparatus (10) includes an applicator (16) having a first and a second end, the applicator (16) defining a feeding chamber (22) for the reception therein of the coating material (12). The applicator (16) includes a fixed lip (24) which extends from the feeding chamber (22) towards the web (14). A movable lip (26) extends from the feeding chamber (22) such that when the movable lip (26) is disposed in a first disposition thereof, the movable lip (26) cooperates with the fixed lip (24) for defining therebetween a slot for guiding the coating material (12) from the feeding chamber (22) towards the moving web (14). However, when the movable lip (26) is pivoted away from the fixed lip (24) to a second and third disposition thereof, flushing and cleaning of the applicator (16) is permitted.
Patent NZ-537076-A (NZ)
Title: Pyrimidinone compounds, compositions and methods
Inventor: ZHOU HAN-JIE
IPC: C07D239/36
Filed: 2003-05-02
Abstract: Pyrimidinone compounds and their compositions useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Patent NZ-537272-A (NZ)
Title: An apparatus and method for beating and rolling a food dough belt
Inventor: HAYASHI TORAHIKO
IPC: A21C3/02
Filed: 2003-06-09
Abstract: Conventionally, it has been necessary to use abundant dusting powder to prevent food dough from adhering to a rolling apparatus. A plurality of rolling rollers move sequentially upstream from downstream or downstream from upstream along the food dough belt, while each rolling roller rotates on its own axis. The moving direction of the rolling roller is changed according to technical requirements. The number of beats is regulated by changing the moving speed V1 of the rolling roller. Further, the peripheral speed of the rolling roller is made to be equal to or almost equal to the surface speed of the food dough belt by changing the rotating speed V2 of the rolling roller. Accordingly, it is possible to reduce the amount of dusting powder and also to make the internal phase of bread dough uniform.
Patent NZ-538818-A (NZ)
Title: Method and apparatus for converting mixture of water and ethanol into fuel
Inventor: ZHANG PUHUA
IPC: F02M25/022
Filed: 2002-11-11
Abstract: Methods and apparatus for creating fuel from a mixture of water and ethanol are disclosed. The water and ethanol are mixed in a certain ratio and the mixture is then heated and evaporated to obtain a vapour mixture which is then passed through a DC electric field. The apparatus has a tank 8 filled with the water/ethanol mixture connected by a flow control valve 9 to an indirect heating type evaporator 11. The resulting vapour passes through a riser pipe made of insulating material, with a negative electrode 2 fixed inside the riser pipe and a positive electrode 3 fixed to the outside. An outlet hole for the combustible gas is formed at the top of the riser pipe and is connected with a fuel gas pipe 4.
Patent NZ-543921-A (NZ)
Title: Aminocyclohexyl ether compounds and uses thereof
Inventor: BEATCH GREGORY N
IPC: A61K31/40
Filed: 2003-10-31
Abstract: Aminocyclohexyl ether compounds of formula (IE), solvates, pharmaceutically acceptable salts, esters, amides, complexes, chelates, stereoisomers, stereoisomeric mixtures, geometric isomers, crystalline or amorphous forms thereof are disclosed; wherein, R4 and R5 are independently selected from C1-C6alkoxy, including isolated enantiomeric, diastereomeric and geometric isomers thereof, and mixtures thereof. These compounds may be incorporated in compositions and kits for pharmaceutical use. These compounds and compositions are suitable for modulating ion channel activity in a warm-blooded animal and may be used for treating various diseases, including the treatment of arrhythmia.
Patent NZ-545822-A (NZ)
Title: An angled sash adaptor
Inventor: HEADS FRANCIS XAVIER
Filed: 2006-03-10
Abstract: Disclosed is a sliding window or a sliding door arrangement that can meet with another window/door or a jamb or other type of member at an angle greater than 90º and less than 180º. The arrangement allows windows and doors to meet at angles without requiring major modifications to an assembly. An angle adaptor is attached to a first window or door or jamb, and a locking means is provided to allow the first member to be locked or latched to a second member. (62) Divided Out of 538203
Patent NZ-546150-A (NZ)
Title: Radiosensitization using isoflavones
Inventor: KELLY GRAHAM EDMUND
IPC: A61K41/00
Filed: 2004-11-19
Abstract: Compounds of formulae (V), (VI) and (VII), wherein the substituents are as defined in the specification, are analogues of genistein such as dehydroequol and can sensitize cancer cells or a tumour to radiotherapy.
Patent NZ-551250-A (NZ)
Title: Neisseria meningitidis 1gtB LOS as adjuvant
Inventor: STEEGHS LIANA JULIANA JOSEPHINE
IPC: A61K39/095
Filed: 2005-05-11
Abstract: Provided is the use of a Neisserial lipo-oligosaccharide (LOS) in the manufacture of a medicament for raising an immune response against an antigen in a mammal, whereby the Neisserial LOS is has a specified formula, and includes a lipid A moiety which is a wild-type Lipid A moiety or a Lipid A moiety with reduced toxicity and whereby the medicament is prepared for use as an adjuvant with said antigen. The antigen may be from a bacterium, virus, fungus, parasite, cancer cell or allergen.