Patent SG-11201804415Q-A (SG)
Title: Contrast agents
Inventor: LATTUADA LUCIANO
IPC: C07D257/02
Filed: 2016-12-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) (43) International Publication Date ..... ..sr ,„,„.1 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/098038 Publication 11111111101111111111MERIIIIIIIIIIIIIII Al Number (51) International Patent Classification: (74) Agent: RAVIZZA, Claudio; Via Caduti di Marcinelle 13, C07D 257/02 (2006.01) A61K 49/10 (2006.01) 20134 Milan (IT). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/EP2016/080592 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 12 December 2016 (12.12.2016) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, EP15199220.3 10 December 2015 (10.12.2015) EP RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, EP16170953.0 24 May 2016 (24.05.2016) EP TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, EP16194814.6 20 October 2016 (20.10.2016) EP ZA, ZM, ZW. (71) Applicant: BRACCO IMAGING SPA [IT/IT]; Via Egi- (84) Designated States (unless otherwise indicated, for every dio Folli, 50, 20134 Milano (IT). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: LATTUADA, Luciano; Bracco Imaging S.p.A. TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, - CRB, Via Ribes No. 5, 1-10010 Colleretto Giacosa (IT). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, NAPOLITANO, Roberta; Bracco Imaging S.p.A. - CRB, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Via Ribes No. 5, 1-10010 Colleretto Giacosa (IT). BOI, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Valeria; Bracco Imaging S.p.A. - CRB, Via Ribes No. 5, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 1-10010 Colleretto Giacosa VISIGALLI, Massimo; (IT). GW, KM, ML, MR, NE, SN, TD, TG). Bracco Imaging S.p.A. - CRB, Via Ribes No. 5, 1-10010 Declarations under Rule 4.17: Colleretto Giacosa (IT). AIME, Silvio; University of Torino Dept. of Molecular Biotechnologies and Health Sci- — as to applicant's entitlement to apply for and be a granted ences, Molecular Imaging Center Via Nizza 52, 10126 4.170) patent (Rule Torino (IT). GIOVENZANA, Giovanni, Battista; Uni- of inventorship (Rule 4.17(iv)) versita. degli Studi del Piemonte Orientale \"A. Avogadro\" Largo Donegani 2/3, 28100 Novara (IT). FRINGUELLO Published: MINGO, Alberto; Bracco Imaging SpA - CRB Via Ribes with international search report (Art 21(3)) No.5, 1-10010 Colleretto Giacosa (IT). Il .4t GC M C::: , GC Cr \ C::: , IN I'l 0 (54) Title: CONTRAST AGENTS ei en. ) (57) : The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal 7 ° ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5