Patent SG-11201804294W-A (SG)
Title: Tank-binding kinase inhibitor compounds
Inventor: DU ZHIMIN
IPC: C07D401/14
Filed: 2016-12-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) (43) International Publication Date .... ....r .....) 22 June 2017(22.06.2017) WIPO I PCT ID Hit (10) WO 111111111111111111IIIIIIII International II 2017/106556 Publication 1111111111111HH11111111111111111111IIIIIII Number Al (51) International Patent Classification: (US). WANG, Peiyuan; do Gilead Sciences, Inc., 333 C07D 401/14 (2006.01) C07D 239/42 (2006.01) Lakeside Drive, Foster City, CA 94404 (US). WATKINS, C07D 413/14 (2006.01) C07D 413/12 (2006.01) William J.; do Gilead Sciences, Inc., 333 Lakeside Drive, CO7D 401/10 (2006.01) A61K 31/4433 (2006.01) Foster City, CA 94404 (US). CO7D 401/12 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) A61P 37/00 (2006.01) (74) Agents: LECHNER, Jolie D. et al.; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). (21) International Application Number: PCT/US2016/067022 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 15 December 2016 (15.12.2016) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (30) Priority Data: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/268,846 17 December 2015 (17.12.2015) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/425,396 22 November 2016 (22.11.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: GILEAD SCIENCES, INC. [US/US]; 333 ZA, ZM, ZW. Lakeside Drive, Foster City, CA 94404 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: DU, Zhimin; c/o Gilead Sciences, Inc., 333 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Lakeside Drive, Foster City, CA 94404 (US). DORNAN, David; Gilead Sciences, Inc., 333 Lakeside Drive, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, c/o Foster City, CA 94404 GUERRERO, Juan A.; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (US). c/o DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA L V, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 94404 (US). KAPLAN, Joshua A.; c/o Gilead Sciences, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). GW, KM, ML, MR, NE, SN, TD, TG). KNOX, John E.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 NADUTHAMBI, (US). Declarations under Rule 4.17: — Devan; Gilead Sciences, Inc., 333 Lakeside Drive, c/o - - Foster City, CA 94404 (US). PHILLIPS, Barton W.; c/o as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 STINSON, Susanna Y.; Gilead Sciences, — (US). c/o as to the applicant's entitlement to claim the priority of the Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). earlier application (Rule 4.17 (iii)) - VENKATARAMANI, Chandrasekar; c/o Gilead Sci- Inc., 333 Lakeside Drive, Foster City, CA 94404 ences, [Continued on next page] Title: TANK KINASE INHIBITOR COMPOUNDS (54) -BINDING , _ ,... ( R )n ;C i HN --- r N \ \ N o x ,,,,, ,,_„, t X 44 '' in x CN In C:::, 11 IN 1-1 (57) : Compounds having the following fol mla (I) 0 ei R 5 and X 2 (I) methods of their use and preparation are disclosed. O WO 2017/106556 Al IMIOHO11111 1E1 IIIIIMEMOMM11011111E11111111111111111011110111111 Published: — with international search report (Art. 21(3))