baber/WOPTO huggingface dataset:
Patent CA-2370103-A1 (CA)
Inventor: FARSON DEBORAH
IPC: A61K35/76
Filed: 2000-04-26
Abstract: Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
Patent CA-2370117-A1 (CA)
Title: Method of detection of cytochrome b mutations in funghi leading to resistance against anti-fungal agents
Inventor: THEAKER JANE
IPC: C12Q1/68
Filed: 2000-04-26
Abstract: The invention discloses methods which are particularly sensitive for detecting low frequencies of mutations in mitochondrially encoded genes, such as the cytochrome b gene, making these an especially useful and commercially important way of screening plant pathogenic fungi for the onset of fungicidal resistance wherein the resistance is due to a mutation in a mitochondrially encoded gene. The methods disclosed include single nucleotide polymorphism detection techniques especially PCR detection methods. Also disclosed are DNA  sequences encoding part of the wild type and mutant cytochrome b sequences of a range of plant pathogenic fungi and the use of the sequence information to detect mutations giving rise to fungicidal resistance. Allele specific oligonucleotides and oligonucleotide probes, diagnostic primers and diagnostic kits are also disclosed.
Patent CA-2370909-A1 (CA)
Inventor: CLUZEL GUY
IPC: B60C9/18
Filed: 1999-05-14
Abstract: Pneumatique P à armature de carcasse radiale (1) de largeur axiale maximal S0, comprenant une armature de sommet (3) formée d'au moins deux nappes de sommet de travail (32, 34) ayant des largeurs axiales L32, L34 supérieures à la largeur L33 d'une armature additionnelle (33) d'éléments de renforcement, inextensibles et sensiblement radiaux, disposée radialement entre lesdites nappes (32, 34), et étant axialement composée de trois parties, une partie centrale sous forme de nappe (33') formée d'éléments de renforcement inextensibles et sensiblement radiaux, ayant une largeur et deux parties latérales sous formes de bandes (33") formées chacune d'éléments de renforcement circonférentiels, le module d'élasticitié à la traction par unité de largeur d'une bande latérale (33") étant au plus égale au module d'élasticité  à la traction, mesuré dans les mêmes conditions, de la nappe de travail (32, 34) la plus extensible.
Patent CA-2372415-A1 (CA)
Inventor: SMILJANIC ALEKSANDRA
IPC: H04M11/06
Filed: 2002-02-19
Abstract: A method for sending data from a transmit site to a receive site which includes dividing a transmit data stream having a first bit rate into multiple data streams with each of the multiple data streams having a bit rate which is lower than the first bit rate, transmitting each of the multiple data streams over a plurality of RF channels and recombining the multiple data streams at the receive site to provide a receive data stream having a bit rate equal to the first bit rate.
Patent CA-2373239-A1 (CA)
Title: Stability, biocompatibility optimized adjuvant (sba) for enhancing humoral and cellular immune response
Inventor: MULLER RAINER HELMUT
IPC: A61K39/39
Filed: 2000-05-19
Abstract: The invention relates to a stability and biocompatibility-optimized adjuvant (SBA) for enhancing the humoral and cellular immune response by jointly injecting said adjuvant with one or more antigens. The adjuvant consists of particles based on solid lipids or solid lipid mixtures and can be used in the production of more efficient and compatible vaccines, the inoculation of human beings and animals and for obtaining antibodies. The strength of the immune response can be modulated in a targeted manner and additionally adapted to the specific species by selecting the size, charge and surface characteristics of the particles. Other adjuvants, e.g. molecular adjuvants such as GMDP, can be added to the SBA, whereby the cellular immune response is additionally enhanced. The SBA is more effective and cost-efficient and easier to use than existing products and is well tolerated in vivo.
Patent CA-2376312-A1 (CA)
Title: Keyed intervertebral dowel
Inventor: SCARBOROUGH NELSON L
IPC: A61F2/46
Filed: 2000-06-08
Abstract: An intervertebral implant (50) having a tabbed configuration is provided. The intervertebral implant includes a substantially cylindrical body portion (52), and a pair of radially extending tabs (62, 64). The radially extending tabs may be provided as a single or double pair (66, 68), may assume various shapes, and configurations for engaging the interior of a bore (E) formed between adjacent vertebrae (X, Y). A through bore (60) or plurality of through bores extend from the top surface (58) of the implant to the bottom surface (70) of the implant. The implant may be formed from a cortical ring (C) cut from the diaphysis of a long bone (D) by milling. Alternatively, the implant may be formed of any biocompatible material having the requisite strength requirements via any known process, i.e., molding. There is also disclosed a method of insertion of the implant including forming a stepped bore between adjacent vertebrae, inserting the implant between adjacent vertebrae with tabs in alignment with the spaced defined by the adjacent vertebrae, and rotating the implant such that the tabs are rotated within an enlarged or stepped portion of the bore to secure it therein.
Patent CA-2376630-A1 (CA)
Title: Induction of vascular endothelial growth factor (vegf) by the serine/threonine protein kinase akt
Inventor: GUO KUN
IPC: A61K33/244
Filed: 2000-06-01
Abstract: The present invention relates to methods and compositions for therapeutic angiogenesis. More especially, this invention is directed to induction of vascular endothelial growth factor (VEGF) expression by the serine/threonine protein kinase AKT. Preferably, the compositions and methods according to the invention comprise a nucleic acid encoding AKT, and administration thereof.
Patent CA-2376956-A1 (CA)
Title: Charged compounds facilitate viral transduction of cells
Inventor: HORSBURGH BRIAN
IPC: A61K35/76
Filed: 2000-06-12
Abstract: The invention provides viral vectors and charged molecules for use in gene therapy.
Patent CA-2379834-A1 (CA)
Title: Agents therapeutiques anti-infectieux catalyses par des enzymes
Inventor: SHEPARD H MICHAEL
IPC: A61P31/04
Filed: 2000-07-21
Abstract: L'invention concerne une méthode permettant d'inhiber sélectivement un agent infectieux ou une cellule infectée par un agent infectieux en mettant ledit agent infectieux ou ladite cellule infectée par l'agent en contact avec un promédicament qui est sélectivement converti en une toxine au moyen d'un enzyme d'activation exprimé par l'agent infectieux. Cet enzyme d'activation est sélectif pour l'enzyme exprimé par l'agent infectieux en comparaison avec l'enzyme identique ou similaire exprimé par la cellule hôte ou d'autres agents infectieux. L'agent d'activation n'est ni inhibé ni inactivé par le promédicament. L'invention concerne également des cribles permettant d'identifier des promédicaments.
Patent CA-2380761-A1 (CA)
Title: Low-pressure discharge lamp
Inventor: STOLL FRANZ
IPC: H01J61/26
Filed: 2002-04-04
Abstract: The invention discloses a low-pressure discharge lamp (1) having a discharge vessel (2) which contains mercury. To prevent mercury from being consumed, a reducing agent (20) is introduced into the discharge vessel (2), which reducing agent is such that it bonds oxygen in the temperature range between room temperature and temperatures up to 900°C and can reduce mercury oxide.
Patent CA-2381914-A1 (CA)
Title: Refastenable absorbent article
Inventor: SCHMOKER SUZANNE MARIE
IPC: A61F13/58
Filed: 2000-08-23
Abstract: An absorbent article is disclosed having a refastenable mechanism. The absorbent article has a front portion, a back portion and a crotch portion. The crotch portion connects the front portion to the back portion. The front  portion has a first end, a second end, a first side edge and a second side edge. First and second lateral sections are releasably attached to the front  portion and each of the first and second lateral sections has an outer edge.  The back portion has first and second side edges and first and second ends. The back portion is divided into a first section and a second section. The first section has a length L2 measured perpendicularly from the first end of  the back portion to a line drawn parallel thereto. The second section has a length L3 measured perpendicularly from the second end of the back portion t o the line drawn parallel to the first end whereby a ratio L2/L3 is establishe d which ranges from between about 0.1 to about 2. The absorbent article furthe r includes an absorbent secured to at least one of the front, back or crotch portions. Each of the outer edges of the first and second lateral sections a re secured to one of the first and second side edges of the back portion to for m a pant-like article having a waist opening and a pair of leg openings.</SDOA B>
Patent CA-2386098-A1 (CA)
Inventor: RAUSA JOHN
IPC: B60C1/00
Filed: 2002-05-13
Abstract: The present invention relates to silica-filled halogenated butyl elastomers, in particular bromobutyl elastomers (BIIR) wherein the silica is surface-functionalized with a protein.
Patent CA-2387294-A1 (CA)
Inventor: WATKINS JACQUELINE T
IPC: G09B19/22
Filed: 2002-05-22
Abstract: An educational treasure hunt game provides for teaching young children or others the basics of writing and reading, by conducting a physical search for cards placed or concealed throughout a predetermined area in accordance with clues provided. A series of cards include pictorial representations of various articles or objects on the front face thereof, with the cards having one or more written clues on the reverse face thereof. Each clue corresponds to a pictorial representation shown on the front face of the next successive card in the series, with all the cards being arranged in alphabetical order according to the first letter of the name of the object or article pictured. The back faces of the cards may include more than one clue, with a corresponding number of cards being provided in order to provide sufficient pictorial symbols. The game is played by placing or concealing the cards adjacent to articles or objects corresponding to their pictorial representations. The game supervisor then reads the first clue, and players engage in a physical search for the object or article corresponding to that clue. When the object and its associated card are found, the supervisor reads a clue from the discovered card, and the process continues. Players are provided with a board and marker to record the first letter or the name of the object depicted on each card found. One or more prizes may be provided at the end of the search, if desired.
Patent CA-2388468-A1 (CA)
Inventor: GUICHERIT OIVIN M
IPC: A61P21/00
Filed: 2000-10-13
Abstract: La présente invention concerne des procédés et des réactifs permettant d'inhiber des états de croissance aberrants qui résultent de gain de fonction hedgehog, de perte de fonction ptc ou de gain de fonction smoothened. Selon cette invention, la cellule est mise en contact avec un antagoniste d'hedgehog, tel qu'une petite molécule, en quantité suffisante pour permettre un état de croissance aberrant, par exemple pour agoniser une voie ptc normale ou pour antagoniser l'activitésmoothened ou hedgehog.
Patent CA-2389245-A1 (CA)
Title: Water based polymer composition comprising a biopolymer and a polymer resin
Inventor: COLPAERT MARC
IPC: C09D103/04
Filed: 2000-10-28
Abstract: The invention relates to a water based polymer composition comprising a biopolymer and a synthetic polymer resin. The biopolymer results from a mechanical thermoplastic processing of a polysaccharide and/or protein starting material using shear forces in the presence of a crosslinking agent . The synthetic polymer resin consists of a water based hydrophilic resin and/ or hydrophilic/hydrophobic resin. These compositions have a good storage stability. They are intended for the production of coatings with fair properties.
Patent CA-2389600-A1 (CA)
Title: Nouvelles proteines humaines du type melastatin et polynucleotides codant ces proteines
Inventor: ZAMBROWICZ BRIAN
IPC: C12N15/09
Filed: 2000-10-31
Abstract: L'invention concerne de nouvelles séquences humaines polynucléotidiques et polypeptidiques pouvant être utilisées dans des applications thérapeutiques, diagnostiques, et pharmacogénomiques.
Patent CA-2392288-A1 (CA)
Title: Pharmaceutical preparation for the inhalation of antithrombin in anti-inflammatory lung diseases and ards
Inventor: WIEDERMANN CHRISTIAN
IPC: A61K38/57
Filed: 2002-07-03
Abstract: Pharmaceutical preparations for inhalation in inflammatory pulmonary diseases and acute pulmonary failure (=ARDS) are described, by means of which antithrombin III is applied topically.
Patent CA-2393529-A1 (CA)
Inventor: SEALE LISA
IPC: A61P31/04
Filed: 2000-12-21
Abstract: Polypeptides are disclosed that are capable of being isolated from ectoparasitic leeches which inhibit the alternative route of complement activation but which have substantially no effect on complement activation by the classical route. The polypetides can be prepared from leech species of the boder Rhynchobdellida and more particulary those of the genus Placobdella, especially of the species Placobdella papillifera. Alternatively, the polypeptides can be synthesised chemically or produced by transgenic organisms carrying DNA sequences which encode them. Accordingly, also disclosed are nucleic acid sequences capable of expressing the polypeptides; hosts, and vectors comprising these sequences; and the use of the nucleic acids and polypeptides in therapy.
Patent CA-2402344-A1 (CA)
Inventor: REMY MAURICE
IPC: H03M7/30
Filed: 2001-03-07
Abstract: The invention concerns a method for encoding a digitised image comprising several pixel lines, which consists in encoding one line with a series of sub-codes characteristic of the length of the successive fields and their colour. The invention is characterised in that when the image comprises several identical successive lines, it consists in encoding the first of said lines and in completing with a sub-code characterising the repetition of the line and the number of times the line is repeated following said first line; when the image comprises several lines including the same succession of colours, it consists in encoding the first of said lines and in completing said code with a succession of sub-codes characterising the repetition of the succession of colours and the length of different fields of the different lines.
Patent CA-2402962-A1 (CA)
Title: Method for automated dialing of telephone number prefixes
Inventor: HRUSKA JOHN
IPC: H04M1/27485
Filed: 2002-09-12
Abstract: A method for appending a dialing prefix to a telephone number digit string which has been dialed from a calling party is provided which comprises the steps of storing the dialed telephone number digit string in a buffer, marking the telephone number digit string stored in said buffer to define the local line number, checking whether the dialing prefix and local line number provides a valid network address, determining a correct dialing prefix to reach the destination party, advising the calling party via a computer-generated audio message of the connect dialing prefix required to reach the destination party, appending the correct area code prefix to the local line number; and automatically connecting the call to a destination party. The dialing prefix can include 1+, 0+, area codes, international access codes, and. foreign country and city codes. The caller can be prompted for manual input of the collect dialing prefix using the touch tone keypad, or the prefix can be appended automatically. The method can include the steps of advising the caller via a computer-generated audio message that a fee will be incurred for automatic placement of the call, In a second embodiment, the caller can dial a seven-digit number sand select the desired geographic region from an audio menu. In a third embodiment for a telephone system having a single area code assigned to a plurality of regions, a method is provided by which calling party can dial a ten-digit number and select the desired geographic region from an audio menu.
Patent CA-2405547-A1 (CA)
Inventor: ICHIDA TAKAFUMI
IPC: A61K38/21
Filed: 2001-04-20
Abstract: L'invention concerne l'administration d'IFN-.beta., avant une transplantation hépatique, afin de prévenir une réinfection par le virus de l'hépatite C après ladite transplantation, cette action étant une mesure préventive contre ladite réinfection.
Patent CA-2405968-A1 (CA)
Title: Hydantoin derivatives with affinity for somatostatin receptors
Inventor: BERNEY DANIEL
IPC: A61P9/00
Filed: 2001-05-07
Abstract: The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3 and R4 are as defined in the description, and the preparation thereof. The compounds of the formula bind to somatostatin receptors and are useful as pharmaceuticals.
Patent CA-2406024-A1 (CA)
Inventor: CAPELLI-SCHELLPFEFFER MARY
IPC: A61K45/06
Filed: 2001-03-16
Abstract: La présente invention concerne des compositions, des procédés et des trousses qui permettent d'améliorer la taille et l'aspect d'une blessure fermée ou d'une cicatrice. La composition contient une quantité thérapeutiquement efficace d'au moins un inhibiteur de cyclooxygénase, d'un inhibiteur NF-kB ou d'un anti-irritant. Pour l'application topique, transdermique, l'inhibiteur de cyclooxygénase ou l'inhibiteur NF-kB peut être présent dans une matière thermo-isolante telle qu'un hydrogel. La matière thermo-isolante peut également contenir un agent désodorisant pour réduire les bactéries en surface et la formation d'odeurs.
Patent CA-2406618-A1 (CA)
Title: Method and apparatus for dna sequencing
Inventor: IZMAILOV ALEXANDRE M
IPC: C12Q1/68
Filed: 2001-04-12
Abstract: The sequence of a target DNA molecule is determined by preparing four chain termination reaction mixtures, one for each base type. The first set of fragments, indicative of the positions of a first type of base, are labeled with a first fluorescent label. The second set of fragments, indicative of t he positions of a second type of base, are labeled with a second fluorescent label different from the first fluorescent label. The third set of fragments , indicative of the positions of a third type of base, are labeled with a thir d fluorescent label, different from the first and second fluorescent labels or  with at least two labels, including at least one fluorescent label selected from among the first, second and third fluorescent labels. The fourth set of  fragments, indicative of the positions of a fourth type of base, are labeled  differently from the third set of chain-termination fragments and with at least two different species of labels including at least one fluorescent lab el selected from among the first, second and third fluorescent labels. Thus, a total of only three fluorescent labels are required to label the DNA sequencing fragments. The first, second, third and fourth sets of chain- termination fragments are loaded onto the same lane of an electrophoresis separation medium and separated in an electric field. The separated fragment s are detected in real-time as they migrate in the electrophoresis separation medium by irradiating the separated fragments with an excitation beam and collecting light emitted by the fluorescent labels in three optical channels . The signals from three optical channels are evaluated to determine a DNA sequence for the target species. This evaluation can be done with a specifically programmed computer.
Patent CA-2410701-A1 (CA)
Inventor: DUPUIS JESSE
IPC: F16H7/08
Filed: 2001-06-13
Abstract: A method of manufacturing a tensioner (10) by mounting an end member (38) on an end of a hollow tensioner shaft (24) includes a step of providing an end member (38) of sheet material with an opening (76) having a plurality of annularly spaced inwardly extending pointed projections (78). A hollow shaft (24) has an outwardly extending shoulder (82) at an end portion thereof. A  relative axial movement between the end member (38) and the hollow shaft (24) is effected so that the end member (38) abuts against the shoulder (82) of the hollow shaft (24). The hollow shaft (24) is deformed at the end portion radially outward to embed the projections (78) into the hollow shaft (24) to thereby form a joint (32) therebetween.
Patent CA-2411017-A1 (CA)
Inventor: KIRCHHOFF CHRISTIANE
IPC: C12N1/21
Filed: 2001-06-08
Abstract: The invention relates to novel epididymis-specific proteins with fibronectin type II modules, to derivatives and fragments thereof, to DNA sequences that code for these, and to their utilization for producing pharmaceutical compositions used for diagnosing and treating male infertility as well as for contraception.
Patent CA-2412374-A1 (CA)
Title: Nouvelles peptides de tete permettant d'augmenter la secretion d'une proteine recombinee dans une cellule hote
Inventor: CHEN TSENG-HUI T
IPC: C07K19/00
Filed: 2001-06-05
Abstract: La présente invention concerne l'identification de nouvelles peptides synthétiques de tête. On utilise ces peptides de tête dans une méthode d'augmentation de la sécrétion d'un polypeptide recombiné produit dans une cellule hôte. Par ailleurs, cette invention concerne des polynucléotides qui codent ces nouvelles peptides de tête et un procédé de mise au point de ces polynucléotides.
Patent CA-2412792-A1 (CA)
Inventor: BRISEBOIS DONALD
IPC: E21C37/16
Filed: 2002-11-26
Abstract: A free-blast method for extracting ore from an ore vein deposit wherein the vein is extracted by causing the ore comprised between the rock walls bordering the vein to spall into fragments. The ore fragments are recuperated as by aspiration and subsequently processed to retrieve the precious mineral.
Patent CA-2413293-A1 (CA)
Inventor: FRYER JEREMY EDWARD
IPC: H05H1/34
Filed: 2001-06-07
Abstract: A thermal tool (100) for high temperature work such as plasma welding or cutting has a replaceable nozzle (102) coupled to an elongate support (106) via interengaging threaded portions (108, 110) on each. The threaded portions are tapered and good heat conduction is provided from the nozzle to the elongate support, giving the nozzle a longer life. The nozzle can be readily removed and changed. A fluid-cooling channel (120) is enclosed in the second part adjacent the interengaging threads, which may be buttresstype threads.
Patent CA-2416087-A1 (CA)
Title: Shipping and transportation optimization system and method
Inventor: WEBER DAVID
IPC: G06Q10/00
Filed: 2001-07-13
Abstract: Published without an Abstract
Patent CA-2418973-A1 (CA)
Inventor: TEEPLE ELLARD
IPC: H01R13/58
Filed: 2003-02-14
Abstract: A computer extension cable comprising: a plurality of individual cables, each individual cable having two ends and a connector at each end, the connectors for connecting a computer to a peripheral device, each individual cable comprising a plurality of conductors and surrounded by a shielding means; a unitary cable comprising the plurality of individual cables in close proximity to one another surrounded by a sheath, the sheath for preventing entanglement of the individual cables and for protecting the individual cables, the unitary cable having two ends; a strain relief at each end of the unitary cable for preventing damage to the unitary cable due to separation of the plurality of individual cables; and, an interference reducing means for reducing interference between the individual cables.