Patent SG-11201407546Q-A (SG)
Title: Novel ring-substituted n-pyridinyl amides as kinase inhibitors
Inventor: BURGER MATTHEW
IPC: C07D407/14
Filed: 2013-05-20
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/175388 A1 (51) International Patent Classification: C07D 403/12 (2006.01) C07D 401/14 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/054145 20 May 2013 (20.05.2013) English (30) Priority Data: 61/649,645 61/695,533 21 May 2012 (21.05.2012) 31 August 2012(31.08.2012) English US US (71) Applicant (for all designated States except US): NO- VARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH). (72) Inventors; and (71) Applicants (for US only): BURGER, Matthew [US/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608-2916 (US). DRUMM III, Joseph [US/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608- 2916 USA (US). NISHIGUCHI, Gisele [US/US]; No­ vartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608-2916 (US). RICO, Alice [US/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608-2916 (US). SIMMONS, Robert Lowell [US/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608-2916 (US). TAFT, Benjamin [US/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608-2916 (US). TAN­ NER, Huw [GB/US]; Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Emeryville, California 94608- 2916 (US). (74) Common Representative: NOVARTIS AG; Lichtstrasse 35, CH-4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS H?N 00 00 m i> i-H (57) Abstract: The present invention provides compound a of formula (A): I as described herein, and pharmaceutically acceptable © salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating disease a or condition mediated CJ by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds. WO 2013/175388 A11 lllll llllllll II llllll III lllll lllll lllll lllll III III III lllll lllll lllll llll llll lllllll llll llll Published: — with international search report (Art. 21(3))