baber/WOPTO huggingface dataset:
Patent WO-2018140401-A2 (WO)
Inventor: PARRON JEROME
IPC: H04L47/2466
Filed: 2018-01-23
Abstract: Technology for a user equipment (UE), operable to generate an enhanced buffer status report (eBSR) is disclosed. The UE can identify packets for uplink transmission. The UE can filter the packets for uplink transmission, to identify a number of small packets pending for transmission and a number of larger packets, relative to the small packets, that are pending for transmission in the uplink transmission. The UE can encode the eBSR for transmission to a next generation node B (gNB), wherein the eBSR includes information identifying the number of small packets pending for transmission. The UE can have a memory interface configured to send to a memory the number of small packets pending for transmission.
Patent WO-2019051274-A2 (WO)
Title: Devices for treating lung tumors
Inventor: PANESCU DORIN
IPC: A61B18/14
Filed: 2018-09-07
Abstract: An apparatus (150) for ablating a tumor in a lung including: an elongate shaft (149); an obturator (152) positioned at a distal region of the elongate shaft, a suction lumen (166) extending through the elongate shaft and exiting the shaft distal to the obturator, wherein the suction lumen is configured to remove air or fluid from the portion of the lung, an ablation catheter delivery lumen (153) extending through the elongate shaft and exiting the shaft distal to the obturator, and an ablation catheter (155, 154) comprising an RF electrode (156, 157).
Patent WO-2019055878-A2 (WO)
Title: Multiplex production and barcoding of genetically engineered cells
Inventor: ROY KEVIN
IPC: C40B30/06
Filed: 2018-09-14
Abstract: The present disclosure relates to multiplex production and phenotyping of genetically engineered cells using RNA-guided nucleases and genomic barcoding. In particular, high-throughput multiplex genome editing is achieved utilizing a system that facilitates precise genome editing at desired target chromosomal loci by homology directed repair. Integration of guide RNA and donor DNA sequences as a genomic barcode at a separate chromosomal locus allows identification, isolation, and massively-parallel validation of individual variants from a pool of transformants. Strains can be arrayed according to their precise genetic modifications, as specified by donor DNA incorporation in heterologous or native genes. The present disclosure further relates to a method of editing codons outside of canonical guide RNA recognition regions, which enables complete saturation mutagenesis of protein-coding genes, a marker-based internal cloning method, which removes background due to oligonucleotide synthesis errors and incomplete vector backbone cleavage, and a method of enhancing homology directed repair by active donor recruitment.
Patent WO-2019221782-A2 (WO)
Title: Semi-autonomous motorized weapon systems
Inventor: BOCKMON BRYAN STERLING
IPC: F41G1/00
Filed: 2018-11-05
Abstract: Various techniques are described herein for controlling autonomous and semi-autonomous motorized weapons systems. In various embodiments, semi-autonomous motorized weapons systems may perform automated target identification, selection and prioritization techniques. Dynamic target tracking may be performed, for both primary and secondary targets, in cases of stationary and moving targets and weapon systems. A motorized weapon system then may be actuated automatically toward a firing solution target point, during which the operator-controlled firing mechanism may be enabled or disabled based on the projected point of impact of the weapon in comparison to a determined boundary area associated with the target.
Patent WO-2019136202-A2 (WO)
Inventor: ROTHBERG JONATHAN
IPC: B01L3/00
Filed: 2019-01-04
Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub- micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
Patent WO-2020061257-A2 (WO)
Inventor: HOLT BRANDON
IPC: C12Q1/37
Filed: 2019-09-19
Abstract: Disclosed herein are protease-based biological circuits for use in the diagnosis and treatment of disease and disorders characterized by aberrant protease signaling. An exemplary method of treating disease in a subject includes administering to the subject a plurality of therapeutic agent loaded-liposomes, wherein each of the liposomes comprises a different density of peptides surrounding the core and a different dose of the therapeutic agent, wherein the peptides comprise a cleavage site for a protease of interest, and wherein cleavage of the peptides open the liposome and release the therapeutic agent from within the liposome.
Patent WO-2020150051-A2 (WO)
Title: System and method for testing a data packet signal transceiver
Inventor: OLGAARD CHRISTIAN VOLF
IPC: H04B17/15
Filed: 2020-01-08
Abstract: System and method of testing performance of a data packet signal transceiver (DUT). Multiple DUT signals, with each having a respective DUT transmit power (RDTPn) received by the tester and corresponding to one (IDTPn) of multiple intended DUT transmit powers, for n=1,, m, with a power equal to a minimum IDTP, maximum IDTP, or intermediate IDTP therebetween. Following association of each RDTPn with its IDTPn, a tester signal is sent having a trigger frame and tester transmit output power (TTOP). The trigger frame includes data corresponding to a reported tester transmit power (RTTP), and a desired signal strength (TRSS) of a DUT data packet signal to be received by the tester. A return DUT signal having a RDTPn is received, from which an IDTPn corresponding to the RDTPn is determined and compared to RTTP-TTOP+TRSS. Successive repetitions of such tester and DUT signals and IDTPn comparisons for multiple combinations of values of the TTOP, RTTP and DRSS enable testing reception performance of the DUT, including extracting RSSI measurements, with minimal signal interactions between tester and DUT.
Patent WO-2020181130-A2 (WO)
Title: Polynucleotide conjugates and uses thereof
Inventor: ROY SUBHADEEP
IPC: C12N15/113
Filed: 2020-03-05
Abstract: Provided herein are polynucleotide conjugates comprising a polynucleotide and an agent, wherein the polynucleotide comprises a synthetic double stranded miR-29 mimic and the agent facilitates the delivery of the polynucleotide to a cell type or tissue type involved in fibrosis or inflammation. Also provided are methods of making, and uses thereof.
Patent WO-2022133278-A2 (WO)
Inventor: FREIER SUSAN
Filed: 2021-12-17
Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of FXII RNA in a cell or subject, and in certain instances reducing the amount of FXII protein in a cell or subject. Such compounds, methods, and pharmaceutical compositions are useful to prevent, treat, or ameliorate at least one symptom of a thromboembolic condition. Such thromboembolic conditions include deep vein thrombosis, venous or arterial thrombosis, pulmonary embolism, myocardial infarction, and stroke. Such symptoms include pain, shortness of breath, heart burn, cold sweat, fatigue, lightheadedness, dizziness, swelling, cramping, and death. Such compounds, methods, and pharmaceutical compositions are useful to prevent, treat, or ameliorate at least one symptom of hereditary angioedema.
Patent WO-2023003617-A2 (WO)
Title: Dual aperture dual modem satcom terminal
Inventor: PANTHI SUNIL
Filed: 2022-05-06
Abstract: An aircraft based satellite communication (SATCOM) terminal includes a broadband aperture configured to communicate through non-geostationary orbit (NGSO) satellites for broadband communications, a management aperture configured to receive NGSO satellite management information from a geostationary orbit (GSO) satellite, and at least one processor that performs operations. The operations receive the NGSO satellite management information from the GSO satellite, where the NGSO satellite management information indicates positions and associated time of a set of the NGSO satellites. The operations acquire a second communication link with a second NGSO satellite among the set using the NGSO satellite management information during handoff switching from using a first communication link that was previously acquired with a first NGSO satellite to using the second communication link being acquired with the second NGSO satellite. The operations then perform broadband communications through the broadband aperture and the second communication link with the second NGSO satellite. Related ground-based control centers are disclosed.
Patent WO-2022236191-A2 (WO)
Title: Multiple-venturi nozzle, system, method of manufacture and method of use
Inventor: VANDEGRIFT GIDEON
Filed: 2022-05-11
Abstract: The first object of the present invention is directed to a High Flow Venturi Nozzle capable of diffusing gas into a large quantity of fast-moving liquid. Another object of the present invention is directed to a two-piece High Flow Venturi Nozzle assembly. Another object of the present invention is directed to a method of manufacturing and using the two embodiments noted above. The second object of the instant invention includes a multiple-Venturi nozzle and a system, method of manufacture and method of using same.
Patent WO-2023288289-A2 (WO)
Title: Oligonucléotides et compositions de ceux-ci pour des troubles neuromusculaires
Inventor: SALEH ANTHONY
Filed: 2022-07-14
Abstract: La divulgation concerne des oligonucléotides ciblant DUX4 modifiés destinés à l'inhibition sélective de transcrits d'ARN associés à une maladie neuromusculaire, telle que la dystrophie musculaire facio-scapulo-humérale. La divulgation concerne également des vecteurs contenant l'un quelconque de ceux-ci, des formulations pharmaceutiques contenant l'un quelconque de ceux-ci, ainsi que des kits contenant l'un quelconque de ceux-ci. La divulgation concerne en outre des procédés d'inhibition sélective de l'expression et de l'activité polypeptidiques par la mise en contact d'un oligonucléotide ciblant DUX4 avec un transcrit d'ARN associé à une maladie neuromusculaire telle qu'une dystrophie musculaire facio-scapulo-humérale.
Patent WO-2023010094-A2 (WO)
Title: Methods and compositions for treating cancer
Inventor: LIU QINGYUAN
Filed: 2022-07-28
Abstract: The invention provides methods and compositions for use in treating cancer, e.g., gastric cancer (e.g., a gastric carcinoma (GO) or a gastroesophageal junction carcinoma (GEJC) (e.g., inoperable, locally advanced, metastatic, or advanced GC or GEJC)) or rectal cancer (e.g., locally advanced rectal cancer (LARC)) in a subject, for example, by administering to the subject a treatment regimen that includes an anti-TIGIT antagonist antibody (e.g., tiragolumab) in combination with a PD-1 axis binding antagonist (e.g., atezolizumab). The treatment regimen may be administered with chemotherapy or following a neoadjuvant chemotherapy regimen. Also provided are compositions (e.g., compositions comprising a PD-1 axis binding antagonist (e.g., atezolizumab) and/or an anti-TIGIT antagonist antibody (e.g., tiragolumab), including pharmaceutical compositions thereof, kits thereof, and articles of manufacture thereof) for use in treating cancer, e.g., gastric cancer (e.g., a GC or a GEJC (e.g., inoperable, locally advanced, metastatic, or advanced GC or GEJC)) or rectal cancer (e.g., LARC) in a subject.
Patent WO-2023049789-A2 (WO)
Inventor: ZHOU JIADONG
IPC: C12N9/16
Filed: 2022-09-22
Abstract: La présente divulgation concerne des cellules de levure qui sont génétiquement modifiées pour réduire leur propension à dégrader certains produits chimiques de plateforme, tels que l'acide acrylique, et des procédés de préparation et d'utilisation de telles cellules de levure pour la production d'acide acrylique et d'autres composés.
Patent WO-2023064928-A2 (WO)
Title: Cellules immunitaires ayant des arnsh co-exprimés et des systèmes de porte logique
Inventor: WILLIAMS JASPER
IPC: C07K14/705
Filed: 2022-10-14
Abstract: L'invention concerne des acides nucléiques recombinés codant des récepteurs d'amorçage chimériques qui se lient à ALPG/P, des récepteurs antigéniques chimériques qui se lient à MSLN, et un ARNsh ciblant FAS, PTPN2 et/ou TOX. L'invention concerne également des systèmes de récepteurs d'amorçage chimériques qui se lient à ALPG/P, des récepteurs antigéniques chimériques qui se lient à MSLN, et un ARNsh ciblant FAS, PTPN2 et/ou TOX, des cellules exprimant de telles protéines et ARNsh, et leurs méthodes d'utilisation.
Patent WO-2023133166-A2 (WO)
Title: System and method for determining a cardiac health status
Inventor: EDELBERG JAY M
IPC: G16H50/20
Filed: 2023-01-04
Abstract: Disclosed herein, in some aspects, are systems and methods for detecting, monitoring, and managing a cardiac health status for a subject using ECG data. In some embodiments, the system receives health parameter measurements from one or more devices that are then used by a cardiac health tool (CHT) to determine a cardiac health status. Exemplary health parameter measurements include electrocardiogram (ECG) data from an ECG device and/or weight (from a weight scale for example). As described herein, in some embodiments, determining the cardiac health status includes a) detecting a cardiac condition in the subject, b) predicting a risk of a subject developing a cardiac condition ("cardiac condition risk"), and/or c) temporal monitoring of a cardiac health status for a subject. In some embodiments, the cardiac health tool is configured to determine the efficacy of a treatment or therapy applied to reduce the severity and/or risk of a cardiac condition.
Patent WO-2023137113-A2 (WO)
Title: Chemically reversible 2´-oh acylation protects rna from hydrolytic and enzymatic degradation
Inventor: FANG LINGLAN
IPC: C07H21/02
Filed: 2023-01-12
Abstract: Compositions and methods are provided for the reversible modification of RNA to enhance RNA in-solution and enzymatic stability by reaction with acylimidazoles, sulfonyltriazoles, or sulfonylimidazoles. 2´-OH acylation protects RNA from hydrolytic and enzymatic degradation. Water-soluble organocatalysts can accelerate the reversal of acylation adducts and functionally restore RNAs, alternatively the acylation is spontaneously reversed in a cellular environment. Chemically tuned 2´-OH acylation can be spontaneously released in cells to restore RNA biological functions including translation. mRNA can be selectively modified at the 2´-OH of poly(A)-tail for enhanced in-cell stability and enhanced total protein output.
Patent WO-2023158811-A2 (WO)
Inventor: SHAFER TERRY WAYNE
IPC: E21B43/02
Filed: 2023-02-17
Abstract: Est décrit un conditionneur de fluide multiphase de fond de trou, qui comprend une tête, une base et un séparateur de gaz ayant une pluralité de sorties de gaz et une extrémité de haut de trou et une extrémité de fond de trou. Au moins deux étages de pompe sont reliés de manière fonctionnelle à la tête et à l'extrémité de haut de trou du séparateur de gaz. Chacun des deux étages de pompe ou plus est un étage contrahélicoïdal, un étage centrifuge, un étage centrifuge de prise en charge de gaz, ou toute combinaison de ceux-ci. Le conditionneur de fluide multiphase de fond de trou peut en outre comprendre (1) au moins deux étages de pompe reliés de manière fonctionnelle à la base et à l'extrémité de fond de trou du séparateur de gaz, chacun des deux étages de pompe ou plus étant un étage contrahélicoïdal, un étage centrifuge, un étage centrifuge de prise en charge de gaz, ou toute combinaison de ceux-ci ; ou (2) un étage centrifuge de prise en charge de gaz relié de manière fonctionnelle à la base et à l'extrémité de fond de trou du séparateur de gaz.
Patent WO-2023225059-A2 (WO)
Inventor: BOROUGHS ANGELA
IPC: C07K14/705
Filed: 2023-05-17
Abstract: Provided herein are chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
Patent WO-2023244826-A2 (WO)
Inventor: ULLMANN BERND
IPC: H01M50/581
Filed: 2023-06-16
Abstract: Une unité de batterie comprend un agencement d'une pluralité d'éléments de batterie empilés individuels qui mettent en oeuvre une ou plusieurs techniques de gestion thermique. L'agencement des éléments de batterie empilés génère un refroidissement suffisant à l'intérieur de l'unité de batterie pendant le fonctionnement de la batterie de telle sorte que des mécanismes de refroidissement externes ne sont pas mis en oeuvre. De plus, l'unité de batterie peut comprendre un composant de gestion thermique qui comprend un ou plusieurs matériaux pour transférer la chaleur à l'opposé de l'unité de batterie et/ou un ou plusieurs matériaux pour stocker et libérer la chaleur qui est produite pendant le fonctionnement de la batterie.
Patent WO-2024006127-A2 (WO)
Title: Continuous-wave radar system for detecting ferrous and non-ferrous metals in saltwater environments
Inventor: FONTS CARLOS ALBERTO
IPC: G01S13/89
Filed: 2023-06-21
Abstract: The present invention includes systems and methods for a continuous-wave (CW) radar system for detecting, geolocating, identifying, discriminating between, and mapping ferrous and non-ferrous metals in brackish and saltwater environments. The radar system (e.g., the CW radar system) generates multiple extremely low frequency (ELF) electromagnetic waves simultaneously and uses said waves to detect, locate, and classify objects of interest. These objects include all types of ferrous and non-ferrous metals, as well as changing material boundary layers (e.g., soil to water, sand to mud, rock to organic materials, water to air, etc.). The radar system (e.g., the CW radar system) is operable to detect objects of interest in near real time.
Patent WO-2023196957-A2 (WO)
Inventor: WEINER DAVID
IPC: C07K14/705
Filed: 2023-04-07
Abstract: The present invention provides bispecific binding molecules targeting CD3 and tumor antigens having increased expression and stability, and nucleic acid molecules encoding the same, and methods for treating or preventing a disease or disorder using the same.
Patent WO-2023250248-A2 (WO)
Title: Enteral feeding pump systems, valve assemblies therefor and fluid flow control methods for same
Inventor: SACCHETTI PETER
IPC: A61M1/04
Filed: 2023-05-30
Abstract: A flow selector valve assembly for an enteral feeding pump system (i.e., an enteral feeding pump system including a fluid delivery set with first and second feeding tubes, an enteral feeding pump and a pinching mechanism for regulating the flow of nutrient formula or water out of the first and second feeding tubes), and a twin port adapter for use in the valve assembly. The twin port adapter includes a body configured to receive the first and second feeding tubes therein, and a feeding tube guide rotatably connected to the body and configured to secure the first and second feeding tubes within the body.
Patent BR-102012004078-A2 (BR)
Title: Dual drive electric machine with controllable planetary gear set
Inventor: TAI-HER YANG
IPC: F16H48/06
Filed: 2012-02-24
Abstract: máquina elétrica de acionamento dual com jogo de engrenagens planetárias controlável. a presente invenção refere-se a um dispositivo de embreagem estruturado por uma máquina elétrica de acionamento dual sendo combinada com um jogo de engrenagens planetárias (dg101) e um dispositivo de freio controlável, e através do controle do dispositivo de freio controlável para executar travamento ou liberação de freio, as operações de função de transmissão de conectar transmissão ou liberação entre um eixo de rotação (s101) em uma extremidade de saída/entrada e um eixo de rotação (s102) em uma extremidade de saída/entrada e um eixo de rotação tipo luva (as101) em uma extremidade de saída/entrada do jogo de engrenagens planetárias (dg101) são permitidos de serem controlados, de modo a controlar as operações de interação entre a máquina elétrica de acionamento dual (em100) e as extremidades de saída/entrada.
Patent BR-102012012804-A2 (BR)
Title: Processo para a detecção de ecos múltiplos e ecos de fundo
Inventor: WELLE ROLAND
IPC: G01F23/284
Filed: 2012-05-28
Abstract: PROCESSO PARA A DETECÇÃO DE ECOS MÚLTIPLOS E ECOS DE FUNDO. A invenção refere-se a um processo robusto e um dispositivo para detecção de ecos múltiplos e ecos de fundo, em que as propriedades estatísticas de uma característica comum de dois identificados em uma curva de eco são avaliadas. Esta característica partilhada corresponde a uma razão das posições ou dos valores de velocidade dos dois ecos identificados. Desta forma, pode ser possível classificar os ecos.
Patent BR-102012020682-A2 (BR)
Title: método de validação de uma medição de carbono orgânico total em uma amostra de água , analisador, e, produto de programa para validar uma medição de carbono orgânico total em uma amostra de água usando um analisador
Inventor: GRANT COLLIER MATTHEW
IPC: G01N33/18
Filed: 2012-08-17
Abstract: método de validação de uma medição de carbono orgânico total em uma amostra de água , analisador, e, produto de programa para validar uma medição de carbono orgânico total em uma amostra de água usando um analisador um aspecto provê um analisador para validar uma medição de carbono orgânico total em uma amostra de água , incluindo : um ou mais processadores; e instruções de programa de armazenamento na memória, incluindo: instruções para medir uma quantidade de carbono orgânico total em uma primeira amostra de água usando e obtendo uma primeira medição do mesmo; instruções para identificar um evento de excursão potencial quando uma quantidade de carbono orgânico total da primeira amostra está acima de um limiar predefinido, instruções para capturar uma segunda amostra de água em um frasco respondente à detecção do evento de excursão potencial; instruções para introduzir a segunda amostra no analisador; instruções para medir a quantidade de carbono orgânico total na segunda amostra usando o analisador e obter uma segunda medição do mesmo ; e instruções para comparar a primeira medição e a segunda medição. outros aspectos são descritos e reivindicados.