baber/WOPTO huggingface dataset:
Patent CN-1208285-A (CN)
Title: 具有相位调节功能的半导体集成电路及使用其的系统
Inventor: YONEMORI SHIGEKI
IPC: G06F1/10
Filed: 1998-06-24
Abstract: 一种半导体集成电路包括:一储存设定值的寄存器(7);一根据设定值将输入信号延迟一延迟量以输出按该延迟量延迟的所述信号作为延迟信号(103)的延迟元件组(6)。该半导体集成电路还包括一输入延迟信号(103)和一时钟信号及输出相位调节信号(102)的PLL电路(1)。在这种情况下,相位调节信号(102)被提供给所述延迟元件组(6)作为输入信号。
Patent CN-1247855-A (CN)
Title: 丹参多酚酸盐的制备方法和用途
Inventor: XU YAMING
IPC: C07C59/52
Filed: 1998-09-11
Abstract: 本发明公开一种丹参多酚酸盐的制备方法,采用热水提取大孔树脂分离,精制丹参多酚酸盐。它主要的活性成分为丹酚酸B镁盐,含量高达60%,所得的丹酚酸盐可在心脑血管药物中应用。
Patent CN-1256355-A (CN)
Title: 柔性管路元件
Inventor: GERDELL F U
IPC: F01N13/18
Filed: 1999-10-20
Abstract: 一种尤其是用于汽车内燃机排气管的柔性管路元件,它具有一个波纹管2、至少一个与波纹管2轴向相邻的附件3且尤其是一个金属编织物和/或一个卷绕软管如夹紧软管,其特征在于,在波纹管2与附件3之间布置了局部衬垫。
Patent CR-20110557-A (CR)
Title: Proteinas de fusion rage y metodos de empleo
Inventor: MJALLI ADNAN M M
IPC: A61K38/17
Filed: 2011-10-20
Abstract: Las incorporaciones de la presente invención incluyen proteínas de fusión RAGE y métodos de empleo de dichas proteínas. Las incorporaciones de la presente invención pueden incluir una proteína de fusión que incluye un polipéptido RAGE enlazado a un segundo polipéptido que es diferente al RAGE.
Patent CR-20110610-A (CR)
Title: Nuevos derivados de pirimidina y sus usos en el tratamiento del cáncer y otras enfermedades
Inventor: BENNETT NICHOLAS JAMES
IPC: A61K31/505
Filed: 2011-11-21
Abstract: La invensión se refiera a compuestos de la fórmula (I), donde L1, R1, R2, R3, R4 y X son como se los define en la descripción, La presente invención taambién se refiere a procesos para la preparación de dichos compuestos, composiciones farmáceuticas que los contienen y su uso en el tratamiento de enfermedades.
Patent CR-20130365-A (CR)
Title: Impresora de chorro de tinta para la impresión en tarjetas
Inventor: CAPPELLO PAOLO
IPC: B41J13/12
Filed: 2013-07-29
Abstract: Impresora de chorro de tinta para imprimir en tarjetas que consta de una estacion de impresión (50) que incluye: al menos un cabezal de impresión de chorro de tinta (51)
Patent CR-20160307-A (CR)
Inventor: GIAMPAPA VINCENT C
IPC: C12N5/02
Filed: 2014-12-19
Abstract: Un método que comprende obtener una primera muestra de células de un primer individuo; obtener una segunda muestra de células de un segundo individuo; cultivar la primera muestra de células en presencia de al menos una porción de un medio de cultivo de la segunda muestra de células por un periodo con un rango entre aproximadamente 24 horas y aproximadamente 6 semanas para producir una composición restauradora; y poner en contacto la composición restauradora con la segunda muestra de células por un periodo con un rango entre aproximadamente 24 horas y aproximadamente 6 semanas para producir una composición restaurada.
Patent CR-20160578-A (CR)
Title: Derivados de indolin-2-ona o pirrolo-piridin-2-ona
Inventor: HUMM ROLAND
IPC: C07D471/04
Filed: 2015-06-23
Abstract: La presente invención se refiere a 2-oxo-2,3-dihidro-indoles de fórmula general: en la que: Ar1 es fenilo o un grupo heteroarilo de cinco o seis elementos, que contiene uno, dos o tres heteroátomos seleccionados de entre N, S o O, en el que el heteroátomo N en el grupo heteroarilo puede oxidarse a N+-(O-), R1 es alquilo inferior, halógeno, ciano o cicloalquilo
Patent CR-20200554-A (CR)
Inventor: GERDES CHRISTOPH
IPC: C07D487/04
Filed: 2019-05-10
Abstract: <p> </p> <p>La invención se refiere a derivados sustituidos de la carboxamida dihidropirazolo pirazina y a su proceso de preparación, al igual que a su uso para preparar medicamentos para el tratamiento y/o la profilaxis de enfermedades, en particular de trastornos cardiovasculares, preferentemente de trastornos trombóticos o tromboembólicos y diabetes, y también trastornos urogenitales y oftálmicos.</p>
Patent CR-20220110-A (CR)
Title: Antiviral prodrugs and pharmaceutical compositions thereof
Inventor: CHATTERJEE ARNAB KUMAR
IPC: C07H19/173
Filed: 2020-09-11
Abstract: viral suppression of human immunodeficiency virus (HIV).
Patent CR-20230243-A (CR)
Title: Immunocytokine for activating human il-10ra receptor and use thereof
Inventor: KOLOSOVA ELENA SERGEEVNA
IPC: C12N15/24
Filed: 2021-12-10
Abstract: The present invention relates to the field of biotechnology and medicine, in particular to an immunocytokine for activating the human IL-10Ra receptor. The invention further relates to nucleic acids encoding said immunocytokine, expression vectors, host cells and methods for producing same, methods for producing the immunocytokine, pharmaceutical compositions comprising the above immunocytokine, pharmaceutical compositions comprising the above immunocytokine and other therapeutically active compounds, methods for treating an oncological disease and the uses of the immunocytokine or pharmaceutical compositions thereof for treating an oncological disease.
Patent EC-SP067098-A (EC)
Inventor: MANTLO NATHAN BRYAN
IPC: C07D403/12
Filed: 2006-12-19
Abstract: Compounds of Formula (I): wherein n, m, p, q, Y, R1, R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.
Patent EC-SP067110-A (EC)
Title: Derivados de 2-carbamida-4-feniltiazol, su preparación y su aplicación en terapéutica
Inventor: CASELLAS PIERRE
IPC: C07D277/40
Filed: 2006-12-26
Abstract: La invención tiene por objeto derivados de 2-carbamida-feniltiazol, de fórmula general (I) siguiente: la invención tiene igualmente por objeto composiciones farmacéuticas que contienen un compuesto de fórmula general (I).
Patent EC-SP088515-A (EC)
Title: Mezclas fungicidas que contienen boscalida y pirimetanilo
Inventor: STIERL REINHARD
IPC: A01N43/54
Filed: 2008-06-09
Abstract: Mezclas fungicidas que contienen	(1)	Boscalida de la fórmula (I) 	y	(2) pirimetanilo de la fórmula (ii) En una cantidad sinergéticamente efectiva, procedimiento para combatir hongos nocivos con mezclas de boscalida (I) y pirimetanilo (II) y el uso de boscalida (I) y pirimetanilo (II) para la obtención de tales mezclas, productos, que contienen estas mezclas, así como semillas, que contienen estas mezclas.
Patent EC-SP099396-A (EC)
Title: Nuevos derivados azabicíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
Inventor: LESTAGE PIERRE
IPC: A61K31/44
Filed: 2009-06-09
Abstract: Compuestos de fórmula (I) : en la que :o ALK representa una cadena alquileno,o W representa un grupo elegido entre en el que R y R' son tales como se han definido en la descripción.Medicamento.
Patent EC-SP099656-A (EC)
Title: Anticuerpos ox40 antagonistas y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes
Inventor: YAO ZHENGBIN
IPC: A61K39/395
Filed: 2009-09-25
Abstract: La presente invención es concerniente con anticuerpos antagonistas dirigidos contra el receptor OX40 humano (CD 134) y fragmentos del mismo, en los que se incluyen las secuencias de aminoácidos de anticuerpos antagonistas y los ácidos nucleicos que codifican los anticuerpos. También incluidos en la presente invención se encuentran regiones de enlace de antígeno (CDR) derivadas de las regiones variables de cadena ligera y/o pesada de dichos anticuerpos. Otro aspecto de la presente invención es el uso de anticuerpos antagonistas anti-OX40 en el tratamiento de enfermedades inflamatorias y autoinmunes. La presente invención también es concerniente con secuencias humanizadas de un anticuerpo antagonista AlO y mapeo de epítopo del sitio de enlace del anticuerpo.
Patent EC-SP099716-A (EC)
Title: Extrudidos con enmascaramiento del sabor mejorado
Inventor: KANIKANTI VENKATA-RANGARAO
IPC: A61K9/00
Filed: 2009-11-06
Abstract: La invención se refiere a extrudidos que contienen una o varias sustancia(s) farmacéuticamente activa(s), en donde los extrudidos presentan un diámetro de hebra de 0,5 mm o inferior, así como al uso de estos extrudidos para la preparación de fármacos.
Patent EC-SP951396-A (EC)
Title: Insecticida n-(sustituido arilometilo)-4 [bisubstituido (fenilo) metilo] y piperidinos
Inventor: SILVERMAN IAN R
IPC: A01N43/40
Filed: 1995-03-01
Abstract: La presente invención se trata de compuestos de la siguiente estructura, (gráfico) los correspondientes N - óxidos y sales agriculturamente aceptables, están presentadas como efectivas insecticidas en la cual Q es seleccionado del hidrógeno, hidróxido y flúor R es seleccionado de un herteroarilo que tiene 5 o 6 aros de átomos, y en la cual V es hidógeno, halógeno, alquilo, haloalquilo o alkoxido W y X son seleccionados independientemente del hidrógeno y alkoxido, W y X tomados juntos pueden ser -OCH2 CH2 O- , -CH2C(CH3)2O- , o -OC(CH3)20- , R1 y R2 son seleccionados independientemente del fenilo sustituido con halógeno, alquilo, haloalquilo, haloalkoxido, alquilosulfoniloxido, haloalquilosulfoniloxido y n es 1,2 o 3 con el proviso de que cada mitad alifatica contenga no más que 6 atomos de carbono, el halógeno significa cloro flúor y cada alquilo sustituido en un amino nitrógeno contenga de 1 a 3 átomos de carbono. La manera de preparar estos compuestos también se encuentra presentada.
Patent EC-SP992927-A (EC)
Title: Compuestos triciclicos sustituidos (caso x-12143a)
Inventor: MORIN JOHN
IPC: C07D209/82
Filed: 1999-04-16
Abstract: Se describen nuevos compuestos triciclicos junto con el uso de tales compuestos para inhibir la liberación de ácidos grasos inducida por sPLA2 para el tratamiento de trastornos como el choque séptido.
Patent EC-SP993088-A (EC)
Title: Mejoramiento del sellado de poros con cera y de la aglomeracion con resina de un producto lignocelulosico compuesto
Inventor: CHIU SHUI-TUNG
IPC: C08K5/53
Filed: 1999-08-05
Abstract: Tiene relación con mejora en el sellado de poros con cera y en la aglomeración con resina fenólica de un producto lignocelulósico compuesto hecho mediante prensado en caliente.
Patent FR-1172662-A (FR)
Inventor: VOSSENBERG FRANK A
IPC: B66F9/14
Filed: 1957-02-22
Granted: 1959-02-13
Abstract: 815,558. Masted lift trucks. YALE & TOWNE MANUFACTURING CO. Feb. 14, 1957 [June 15, 1956], No. 5058/57. Class 78 (3). In a masted lift truck, the fork 16 or other load carrier is mounted on a plate 15 which is pivotally attached at 29 and 33 to pairs of links 18, 19 and 20, 21, and the pairs of links are pivoted at 27 and 31 to a back plate 14 carried by the lifting carriage. Hydraulic rams 34 and 35 are provided to pivot the plate 15 about pivots 31 and 27 respectively.
Patent FR-1603154-A (FR)
Title: Fire extinction in tanks contng liquid hydro - carbons
IPC: A62C3/06
Filed: 1968-07-17
Granted: 1971-03-22
Abstract: The fire extinguishing process consists in injecting a gas into a hydrocarbon liquid, such as a fuel oil through a porous plug located near the tank base, approx 0.2 x tank diam. from the central axis when the liquid depth is ca. 1 diam. The plug is a truncated cone; a tube penetrates into the larger base of the plug serving to keep it in position and feed it with gas. Nitrogen from a cylinder passes through a relief valve, a flow-meter and a control valve. The porous plug may also be fixed on the lateral wall of the tank, e.g. on the cover of a manhole. The fine bubbles cause a regular and continuous mixing of the liquid mass and improve the renewal and cooling of the upper layers of the liquid. The plug is made from grains agglomerated by sintering or by means of a ceramic binder, so as to have a very large number of channels of diam. 0.1 mm.
Patent GB-1050039-A (GB)
IPC: B66C23/60
Abstract: 1,050,039. Ships' derricks. GEORGE BROWN & CO. (MARINE) Ltd., and J. G. BROWN. Sept. 10, 1965 [June 12, 1964]. No. 24443/64. Heading B8B. A ship's derrick crane has a bridle 13, Fig. 2, which has a slot 18 at each end, Fig. 3 (not shown), through which respectively extend links 19 interconnecting the topping and hanger ropes 14, 15 of the crane, the slots being such that the ropes form two adjacent sides of a triangle with its apex at the jib 10 of the crane except when the jib is slewed outboard to such an extent that the links reach the inner ends of the slots, the bridle then serving to maintain the optimum spread of the ropes. The crane comprises a mast 11 supporting a cross-tree 12, the jib 10 being pivotally mounted near the foot of the mast and the cross-tree 12 supporting pulleys for the topping ropes. The bridle 13 is in the form of a tube 17 and the slots 18 therein are bounded by plates 18a welded to the tube. The links 19 have eyeholes 20, 21 therein, Fig. 4 (not shown), for respective connection to the hanger ropes 15 and, by means of a pulley, to the topping ropes 14. Each link 19 has four pulleys 22 which run on the edges of the plates 18a, and the links are interconnected by cables 26, 26a so that they travel in unison but in opposite directions. Stop pins may be inserted in the bridle to give a wider spread of the ropes.
Patent GB-1050264-A (GB)
IPC: E04G19/00
Abstract: 1,050,264. Cleaning apparatus. H. SANNER, [trading as SABO MASCHINENFABRIK]. Aug. 30, 1963, No. 34469/63. Heading F2N. An apparatus for cleaning boards, for example shuttering boards, comprise an assembly including a beater shaft 1, rods 11, 12, 13, 14 of circular section which are secured to the shaft 1 and are respectively disposed at angularly spaced locations around the shaft 1 in the form of a cage, a series of blade-like beater elements 21, 22, 23, 24 loosely suspended from each rod and a driving motor 2 for the shaft. The assembly is mounted in a frame which moves in a direction transversely of the axis of the beater shaft 1 during a cleaning operation. In the construction shown the frame consists of a box-like structure, the cleaning assembly being disposed within the frame and the motor on top. The frame is mounted on rollers 6, 16, the former 6 being pivoted between swing arms 4 and being adjustable heightwise of the frame by articulated levers 8, 9. On adjustment having been completed the levers 9 are locked to a pivoted shaft 10 through a bush 25 which is attached to the lever 9.
Patent GB-1051384-A (GB)
IPC: B65G13/00
Abstract: 1,051,384. Conveyers. W. R. HIRE. Feb. 17, 1965, No. 6807/65. Heading B8A. A collapsible roller conveyer comprises identical sections 11, 12, 13 hinged at 14a, 146 to permit folding in accordion style. When unfolded the sections are all in the same plane, Fig. 2 (not shown). Each section has a pair of side rails composed of three separate but connected rectangular segments 15a, 15b, 15c and a sixroll roller section. Rotation of one segment of the rails rotates the whole rail and rotation through 90 degrees to the position in Fig. 3 (not shown) rigidly braces the conveyer against folding. Wheels 41, Fig. 4 (not shown), may replace the rollers 16. The side rails of each section may be of single piece construction, Fig. 8 (not shown). The rollers may be mounted in a jointing member 14, Fig. 14 (not shown), used with the frame construction illustrated in Fig. 13 (not shown). The conveyer may be hinged to be folded section over section, or rolled.
Patent GB-1054798-A (GB)
IPC: G01T3/04
Abstract: 1, 054, 798. Measuring nuclear radiation. COMMISSARIAT A L'ENERGIE ATOMIQUE. Sept. 23, 1963 [Sept. 22, 1962], No.37418/63. Heading G1A. [Also in Division G6] A nuclear radiation detector which is dipped into an irradiated medium such as water, heavy water, organic liquids or the reflector of a swimming pool reactor, consists of a hot and cold junction thermocouple having a chamber which is at ambient temperature (i. e. the temperature of the said medium and the cold junction), which contains a material such as graphite contacting the hot junction and which is heated by the radiation from the said medium, the thermocouple being directly proportional to the power of the radiation from the medium. In the arrangement shown, the chamber 1 consists of a thin walled metallic casing which has two cold junctions SF1 and SF2 secured to its outer surface, and the hot junctions SC 1  and SC 2  are embedded in a block of graphite 4. The junctions are connected to a measuring device, Fig. 2 (not shown), which may include a chart recorder which records the intensity of the neutron flux. The measuring device may include an electronic integrator to enable the total energy during a given time to be obtained. The graphite 4 is used when all kinds of elementary particle radiation is to be detected but other materials may also be used e. g. lead and bismuth for gamma rays, or polyethylene and polystyrene for the sum of fast reactions and gamma rays. From consecutive measurements made with detectors having different materials 4, used at the same measuring location an indication of the energy corresponding to each kind of radiation can be obtained.
Patent GB-1095417-A (GB)
IPC: G03D5/06
Abstract: 1,095,417. Photographic processing apparatus. ILFORD Ltd. Sept. 21, 1966 [Sept.23, 1965], No.40619/65. Heading G2A. A photographic processing apparatus comprises two vessels 1, 4 side by side carrying activator and stabilizer solutions respectively. At least two rollers of a sequence of rollers are associated with each vessel and are arranged to dip in the appropriate solutions and apply it to inserted photographic material. The roller 6, which is the earliest roller of the sequence in the vessel 4, is provided with a smooth surface, e.g. of stainless steel, while the other rollers 3, 7 are rough surfaced, e.g. of rubber. The rollers are driven in such a way that the roller 6 rotates faster than, and, if desired, in the opposite direction to, the rollers 3, 7. More than one smooth surfaced roller may be provided in the vessel 4, subject to the condition that there are enough rough surfaced rollers therein to convey inserted material through the apparatus.
Patent GB-1225090-A (GB)
IPC: B63B35/30
Filed: 1969-10-30
Abstract: 1,225,090. Hopper barges. A. VUYK & ZONENS SCHEEPSWERVEN N.V. 30 Oct., 1969 [31 Oct., 1968], No. 53297/69. Heading B7A. A hopper barge comprises two longitudinal buoyancy chambers 1, 2 hinged together beneath their decks, and one or more hydraulic piston/cylinder units 5 located above and hingedly connected to the decks. The hinged connection 10 of the piston-rod 6 and the hinged connection 12 of the cylinder 7 to the associated buoyancy chamber are equidistant from the vertical longitudinal centre plane of the barge and located near the middle of the piston-rod and the middle of the cylinder respectively.
Patent GB-1228233-A (GB)
IPC: F16C33/12
Filed: 1968-05-01
Abstract: 1,228,233. Bearings. AUTOMOBILES M. BERLIET, and HYDROMECANIQUE ET FROTTEMENT. 1 May, 1968 [5 May, 1967], No. 20648/68. Addition to 1,063,988. Heading F2A. In making the bearing according to Claim 1 of parent Specification, the copper, or alloy containing a major proportion of copper, is applied by flame-spraying. A lubricant, such as molybdenum disulphide (either in powder form, or as an oil suspension), may be applied. The molybdenum layer may be ground and subjected to impregnation with a plastics material such as an epoxy resin.
Patent GB-1231461-A (GB)
IPC: G03D15/00
Filed: 1968-05-02
Abstract: 1,231,461. Laminating process. EASTMAN KODAK CO. 2 May, 1968 [2 May, 1967], No. 20811/68. Heading B5N. [Also in Division B8] An apparatus for updating a strip type information file comprising one or more strips carried in a holder 31 of the stick type, the apparatus comprising a support 30 for the holder, means for guiding a strip along a first path as this strip is slid partly out of a holder carried by the support, a base 110 positioned alongside the first path parallel to strip in this path, means for guiding a web of information bearing areas along a second path which is parallel to the first path, means for attaching to a predetermined area of the strip positioned in the first path adjacent to the base a predetermined area of the web which has been positioned in the second path so as to overlie the predetermined strip area, and means located alongside the second path for severing the said area from the web. In a preferred embodiment, the web of information bearing areas (chips) from spool 21 is fed by rollers operated by knob 24, cut into chips by knife blades 26 and 27, the chips being individually fed to base 110 of chip application station 15, file strips located in stick-type holder 31 being separated by mechanism 32 and the selected strip being manually slid to the required position at base 110. A laminated bonding tape 100 comprising a tape 101 adhesive on one surface and being transversely severed to define a series of removable splices, an apertured tape 102 contiguous with the adhesive surface of tape 101 and provided with perforations 104 and an ahdesive resistant tape 103 disposed against the other surface of tape 102 being fed from reel 105 with tapes 101 and 102 separated from tape 102 being passed under roller 98 and around sprocket 87 to overlie the chip and strip an aperture 104 by shoe 95 to overlie the chip lying on base 110, a splice being forced through and bond it to the strip.
Patent GB-1232922-A (GB)
IPC: H01R13/62
Filed: 1969-03-31
Abstract: 1,232,922. Two-part couplings. SANYU Ltd. 31 March, 1969 [4 April, 1968], No. 16630/69. Heading H2E. A socket part 1, e.g. of phenol resin and a plug part, e.g. of ceramic of an electric connector, which comprise complementary contacts resiliently butting in assembly, are held together in the assembled state by magnet-means provided in the connector. The magnet-means may be housed in either of the socket and plug parts and may comprise a permanent magnet 31 which carries a member 32 of magnetic material on either side, the members 32 protruding out of the socket casing as illustrated. The part 1 or 2 without the magnet-means carries a piece 75 of magnetic material which is attracted and held in the assembled state by the magnetized pieces 32. The magnet-means may alternatively inelude an electromagnet. Female contacts 40 in the socket comprise conductive portions 42 ending in contact pieces and are connected to supply leads 81. Male contacts 60 comprising pins 62 and soldered contact pieces 61 are connected to an electric appliance (not shown) and being urged by springs 70 project out of the plug part 2 which may be mounted on the appliance. A modification (Fig. 6, not shown) uses in the socket part contacts connected to springs which carry current and provide resilient abutment of the contacts with rigid contacts in the plug part. A further modification (Fig. 8, not shown) has the casing of the plug part shaped similarly to that of the socket. A second embodiment (Fig. 7, not shown) comprises an electromagnet and has in use the axis of the connector tilted at a small angle to the horizontal so that a slight horizontal pull on the socket disconnects it from the plug.
Patent GB-1234525-A (GB)
IPC: C07C69/54
Filed: 1969-09-08
Abstract: 1,234,525. Stabilizing unsaturated esters. SUMITOMO CHEMICAL CO. Ltd. 8 Sept., 1969, No. 44209/69. Heading C2C. Unsaturated aliphatic carboxylic acid esters e.g. methacrylates and acrylates, in an aqueous solution are inhibited against polymerization by incorporating a conventional inhibitor and at least one condensed phosphoric acid salt or silicic acid salt. Hydroquinone, hydroquinone monomethyl ether, pyrogallol, resorcinol and methylene blue are the inhibitors mentioned and salts of poly-, meta- and ultraphosphoric acids such as sodium and potassium pyro-, tripoly-, tetrapoly-, tetrameta- and hexametaphosphates and sodium and potassium silicates are specified. Examples describe the stabilization of solutions prepared by the esterification with methanol of methacrylamide sulphate prepared from acetone cyanhydrin and sulphuric acid.
Patent GB-1239400-A (GB)
IPC: C07C51/34
Filed: 1967-12-22
Abstract: 1,239,400. Dicarboxylic acids. IMPERIAL CHEMICAL INDUSTRIES Ltd. 10 Dec., 1968 [22 Dec., 1967], No. 58294/67. Heading C2C. Aliphatic dicarboxylic acids are prepared by oxidizing a cycloalkene with ozonized oxygen in the presence of a reaction medium comprising at least 60% by weight of water. The reaction may be in two steps, the first at - 20 to 30 C. produces an ozonide and the second at, for example, 80 to 120 C., completes the oxidation. Cyclo-octene, cyclododecene, cyclopentene and cyclohexene may be reacted in water or aqueous solution which may be a saturated solution of sodium chloride or contain an emulsifying agent or sulphuric acid.