Patent NZ-293243-A (NZ)
Title: Use of optionally halogenated or sulphonated anthracycline (daunomycin, doxorubicia) derivatives to prepare medicaments for treating amyloidosis
Inventor: SUARATO ANTONINO
IPC: A61K31/7034
Filed: 1995-09-05
Abstract: The use of an anthracycline compound of Formula (A) for treating amyloidosis, cell death and loss of tissue function resulting from neurodegenerative disorders such as AL amyloidosis and Alzheimer's disease. Wherein; R1 represents hydrogen or hydroxy; OR4 wherein R4 is C1-6alkyl, C5-6cycloalkyl or CH2-phenyl optionally substituted by 1,2 or 3 substituents selected from F, Cl, Br, C1-6alkyl, C1-6alkoxy and CF3; or OSO2R5 wherein R5 is C1-6alkyl or phenyl optionally substituted by 1,2 or 3 substituents selected from F, Cl, Br, C1-6alkyl; R2 represents hydrogen, hydroxy or OR4 wherein R4 is defined above; R3 represents hydrogen, methyl or a group of formula YCH2R6 wherein Y is CO, CH2, CHOH or Formula (I), wherein m is 2 or 3 and R6 is hydrogen, hydroxy; NR7R8 wherein R7 and R8 are each independently selected from hydrogen, C1-6alkyl, C2-6alkenyl group optionally substituted with hydroxy, CN, COR9, COOR9, CONR9R10, O(CH2)n NR9R10 (n is 2 to 4) or NR9R10, in which R9 and R10 are each independently selected from the group consisting of hydrogen, C1-12alkyl, C2-12alkenyl or phenyl optionally substituted by one or more substituents selected from the group consisting of C1-6alkyl, C1-6alkoxy, F, Br, Cl, CF3, OH, NR2 or CN; C3-6cycloalkyl optionally substituted with COR9, COOR9 or OH, wherein R9 is as above defined; phenyl C1-4alkyl or phenyl C2-4alkenyl optionally substituted on the phenyl ring by one or more, substituents selected from the group consisting of C1-6alkyl, C1-6alkoxy, F, Br, Cl, CF3, OH, NH2 or CN; or COR9, COOR9, CONR9R10, COCH2NR9R10CONR9COOR10, SO2R9 in which R9 and R10 are as above defined, or R7 and R8 together with nitrogen form; or a morpholino ring optionally substituted with C1-4alkyl or C1-4alkoxy, a piperazino ring optionally substituted by C1-6alkyl, C2-6alkenyl or phenyl optionally substituted by one or more, substituents selected from the group consisting of C1-6alkyl, C1-6alkoxy, F, Br, Cl, CF3, OH, NH2 or CN, or a pyrrolidino or piperidino or tetrahydropyridino ring optionally substituted by OH, NH2, COOH, COOR9 or CONR9R10 wherein R9 and R10 are as above defined, C1-6alkyl, C2-6alkenyl or phenyl optionally substituted by one or more substituents selected from the group consisting of C1-6alkyl, C1-6alkoxy, F, Br, Cl, CF3, OH, NH2, or CN; or a group of formula OR4 or SR4 in which R4 is as above defined; or a group of formula O-phenyl, wherein the phenyl ring is optionally substituted by nitro, amino or NR7R8 as above defined; or a group of formula B or C: wherein D is a group of formula COOR9 or CONR7R8 in which R7, R8 and R9 are as above defined; and X represents a sugar residue of formula (X1) or (X2) wherein R11 and R12 are both hydrogen or one of R11 and R12 is hydrogen and the other is F, Cl, Br or I;  R13 represents hydrogen, hydroxy, C1-4alkoxy, amino, NHCOCF3, N=C(C6H5)2, NHCOR9, NHCONR7R8 or a group of formula E or F in which R7, R8 and R9 are as above defined and p is 0 or 1; R14 and R15 represent hydrogen or one of R14 or R15 is hydrogen and the other is OH, F, Cl, Br, I or a group of formula OSO2R5 wherein R5 is as above defined;  R16 represents CH2OH or R13 as above defined;  R17 represents F, Cl, Br, I or a group of formula OSO2R5 wherein R5 is as above defined.