baber/WOPTO huggingface dataset:
Patent IL-139357-A0 (IL)
Title: New heterocyclically substituted amides, their production and their use
IPC: A61K31/403
Filed: 1999-05-25
Abstract: Fused heterocyclic-substituted (hetero)aromatic carboxylic acid alkylamides (I) are new. Amides of formula (I) and their tautomers, enantiomers, diastereomers, E- and Z-isomers and salts are new. [Image] A : fused cyclic group such as 1,2,3,4-tetrahydroquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl, isoindolin-2-yl or indolin-1-yl, all substituted by (R 4) n in the benzene ring; B' : phenyl, naphthyl, pyridyl, pyrimidyl, pyrazyl, pyridazyl, quinolyl, quinazyl, quinoxalyl, thienyl, benzothienyl, benzofuranyl, furanyl or indolyl; R 1H, alkyl, alkoxy, alkenyl, alkynyl, alkylphenyl, alkenylphenyl, alkynylphenyl, OH, halo, CF 3, NO 2, NH 2, CN, COOH, COOT, NHC(O)T, NHC(O)Ph, C(O)NHR 11, NHSO 2T, NHSO 2Ph, SO 2T or SO 2Ph; T : 1-4C alkyl; R 2alkyl (optionally substituted by phenyl, cyclohexyl, pyridyl, thienyl, indolyl or naphthyl, themselves all optionally substituted by 1 or 2 R 1 groups); R 3H, COOR 5 or C(O)Z; Z : NR 6R 7, 4-(R 15)-piperazino, R 15-substituted pyrrolidino or R 15-substituted piperidino; R 4H, (CH 2) mNR 8R 9, (CH 2) mQ or O(CH 2) mQ'; Q : 4-(R 8)-piperazino, 4-(R 8)-homopiperazino, R 15-substituted pyrrolidino, R 15-substituted piperidino, morpholino, 4-(R 8)-1-piperidinyl or R 8-substituted hexamethyleneimino; Q' : 4-(R 8)-piperazino, 4-(R 8)-homopiperazino, R 8-substituted pyrrolidino, R 15-substituted piperidino, morpholino or 4-(R 8)-1-piperidinyl; R 5, R 8, R 9alkyl (optionally substituted by phenyl, itself optionally substituted by 1 or 2 R 10); R 6H or alkyl; R 7H or alkyl (optionally substituted by phenyl or pyridyl (both optionally substituted by R 10) or by 4-(R 8)-piperazino, 4-(R 8)-homopiperazino, R 15-substituted pyrrolidino, R 15-substituted piperidino, R 8-substituted 1-imidazolyl, morpholino, 4-(R 8)-1-piperidinyl or -(CH 2) oNR 8R 9); R 10H, T, OT, OH, halo, CF 3, NO 2, NH 2, CN, CONH 2, COOH, COOT, NHC(O)T, NHC(O)Ph, NHSO 2T, NHSO 2Ph, SO 2T or SO 2Ph; R 11H or alkyl; R 15H or as R 8; m : 1-6; n : 0-2; o : 0-4; unless specified otherwise alkyl moieties have 1-6C and alkenyl or alkynyl moieties 2-6C. ACTIVITY : Neuroprotective; spasmolytic; antiischemic; cytoprotective; cardiovascular; antitumor; antiinflammatory; antirheumatic. MECHANISM OF ACTION : Cystiene protease inhibitor; calpain inhibitor; cathepsin inhibitor; interleukin-1 antagonist. No results of biological activity tests are given, although test procedures are described.
Patent IL-140634-A0 (IL)
Title: Apparatus for treatment of meniere's disease and similar conditions
IPC: A61M13/00
Filed: 1999-06-29
Abstract: An apparatus for treatment of Ménière's disease by intermittently increasing air (gas) pressure, in an air (gas) pressure chamber in communication with an outwardly sealed external ear volume bordering the tympanic membrane, comprises a peripherally fixed flexible circular diaphragm forming a wall of the chamber and being displaceable in a perpendicular direction essentially without being tensioned. Displacement of the diaphragm away from the chamber is effected by air pressure built up in the chamber, not by a separate displacement device. The apparatus further comprises a linear electromagnetic device for displacing the diaphragm. The apparatus may include systems for gas pressure sensing; chamber pressure equalizing; and microprocessor control, for controlling the displacement of the diaphragm and the pressure equalizing device by a signal input from the pressure sensing device.
Patent IL-142571-A0 (IL)
Title: Apparatus and method for building modeling tools
IPC: G06F12/00
Filed: 1999-10-15
Abstract: A method and system for an extensible macro language is provided. The system for providing the extensible macro language includes a parser and a macro handler for processing macro commands not previously defined in the macro language. The parser analyzes keywords in a macro language expression and recognizes one or more keywords representing macro commands that were not previously defined in the macro language. The macro handler receives the keywords in the macro expression and retrieves from a registry of keywords, an executable code or procedure associated with the keyword. The executable code is run to process the macro command represented by the keyword. The template language registry may be augmented to include any keywords and associated codes for extending the macro language.
Patent IL-145661-A0 (IL)
Title: Pregelatinized starch in a controlled release formulation
IPC: C08K5/00
Filed: 2000-03-24
Abstract: The present invention concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release matrix formulation, and solid dosage forms prepared therefrom, preferably for once daily oral administration. The hydrophilic controlled release formulation comprises pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Preferred hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose.
Patent IL-148622-A0 (IL)
Title: Benzisoxazolyl-pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as d4 antagonists
IPC: A61P25/18
Filed: 2000-09-13
Abstract: The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
Patent IL-150561-A0 (IL)
Title: Method for the preparation of 5-cyanophthalide
IPC: C07D413/04
Filed: 2000-01-14
Abstract: A method for the preparation of 5-cyanophthalide comprising treatment of a compound of formula IV wherein X is O or S; R<SUP>1</SUP>-R<SUP>2 </SUP>are each independently selected from hydrogen and C<SUB>1-6 </SUB>alkyl, or R<SUP>1 </SUP>and R<SUP>2 </SUP>together form a C<SUB>2-5 </SUB>alkylene chain thereby forming a spiro-ring; R<SUP>3 </SUP>is selected from hydrogen and C<SUB>1-6 </SUB>alkyl, R<SUP>4 </SUP>is selected from hydrogen, C<SUB>1-6 </SUB>alkyl, a carboxy group or a precursor group therefore, or R<SUP>3 </SUP>and R<SUP>4 </SUP>together form a C<SUB>2-5 </SUB>alkylene chain thereby forming a spiro-ring; with a dehydration agent or alternatively where X is S, thermally cleavage of the thiazoline ring or treatment with a radical initiator, such as peroxide or with light, to form 5-cyanophthalide, which is an important intermediate used in the preparation of the antidepressant drug citalopram.
Patent IL-152684-A0 (IL)
Title: Use of cyclic ketals as a fragrance
IPC: A61K8/33
Filed: 2001-04-28
Abstract: Compounds of the general formula (I) are described:wherein each of R<1>, R<2>, R<3>, R<4>, R<5 >and R<6 >independently represents a substituent selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, and isopropyl; an wherein x represents either 0 or 1. The compounds are useful as fragrances and as added components in fragrance blends. Methods of improving the harmony, emanation, naturalness an staying power of other fragrance ingredients by the addition of such compounds are also described.
Patent IL-157263-A0 (IL)
Title: Pharmaceutical preparation with rna as hemostatis cofactor
IPC: G01N33/50
Filed: 2003-08-05
Abstract: A composition for promoting coagulation of blood comprising a natural or synthetic RNA, or its fragments or analogs, e.g. peptide nucleic acids, ribozymes or RNA aptamers (collectively (A)), is new. Independent claims are also included for: (1) composition for promoting fibrinolysis or for inhibiting coagulation containing one or more agents (B) that degrade RNA or inhibitory compounds with RNase activity or RNA-complexing capacity; (2) diagnostic process for detecting post-operative hypercoagulative states, complication of pregnancy, tumor status, acute myocardial infarction or sepsis by detecting increased levels of plasma RNA, relative to healthy subjects; and (3) diagnostic agent, containing (A), for qualitative or quantitative determination of the blood coagulation factor VII-activating protein (FSAP) or its proenzyme. ACTIVITY : Antibacterial; Immunosuppressive; Hemostatic; Anticoagulant; Thrombolytic; Cerebroprotective. No biological data given. MECHANISM OF ACTION : Modulating the effects of RNA, released from injured tissue or cells, which is an important initial cofactor in the induction of both extrinsic and intrinsic coagulation pathways; specifically RNA binds to and activates the factor VII-activating protease (FASP). RNA from different sources was added to a turbidimetric coagulation test and the recalcification time (RT) measured. All types of RNA tested significantly reduced RT (no figures given), but pretreatment of RNA with RNase destroyed this effect.
Patent RO-128261-A0 (RO)
Title: Process for obtaining a dental composite
Inventor: FORNA NORINA CONSUELA
IPC: A61K6/02
Filed: 2012-02-22
Abstract: The invention relates to a process for obtaining a dental composite for lining the dental prostheses. According to the invention, the process consists in mixing 100 g of polysiloxane matrix with 40 g silica, added in portions, into a mixer up to homogenization, processing the mixture on a roll with the addition of some pigments for obtaining the desired colour, of a peroxide catalyst for cross-linking and of a controlled-release antibacterial substance.
Patent RO-131730-A0 (RO)
Title: Tw/pw-class power laser irradiation
Inventor: LUNGU PETRICĂ CRISTIAN
IPC: B82Y30/00
Filed: 2016-10-03
Abstract: The invention relates to a method for producing nanometric layers with content of diamond or fullerene nanoparticles, by irradiation with ultrashort pulses within the range of picoseconds and femtoseconds, generated by high power lasers (terawatt - TW or petawatt - PW) and, in particular, to a process of forming diamond/fullerene structures on layers of interest for the nuclear fusion, namely C, Be and W layers. According to the invention, the method of modifying a layer deposited on a graphite sublayer consists in producing, by the thermionic vacuum arc method, a C and W bi-layer with the W layer thickness ranging between 2000...2500 nm and that of the C layer ranging between 180...200 nm, deposited on a parallelepipedal graphite sublayer, guiding some laser beams of short duration 100...300 ps in mono-pulse or multi-pulse, with peak power within the range 10...10watt, with pulse energies in the range of micro-Joule to milli-Joule, by means of a lens, in a focal point having the size of 20 x 2 mm, in order to form, by multi-photon absorption, diamond nanocrystals embedded in an amorphous C matrix. As claimed by the invention, the method of modifying a film deposited on a Si sublayer consists in producing, by the thermionic vacuum arc method, a C, Be and W mixed film on Si sublayer, guiding some laser beams of short duration 100 fs...360 ps in mono-pulse or multi-pulse with peak power within the range of 10...10watt, with pulse energies in the range of micro-Joule to milli-Joule, by means of a condensing lens, in a focal point of a plasma, at the normal pressure of the environment or deuterium at the pressure of 20 mbar, in order to produce structures with content of fullerene, beryllium oxide and/or wolfram oxide.
Patent RO-136002-A0 (RO)
Title: Autonomous rover for collecting and reporting air quality values
Inventor: ILIE ANDREI- GABRIEL
IPC: G08C17/02
Filed: 2022-05-05
Abstract: The invention relates to an autonomous rover for collecting and reporting air quality values. According to the invention, the rover includes a communication module (3) consisting of a Bluetooth module, a SIM GPRS module, an HD video camera module and an active buzzer, a sensor module (2) consisting of a driver and of volatile organic compounds and CO2 sensors, temperature and humidity sensors, ammonia, benzene and hydrogen sensors, for the quantification of dust and pollen particles, a diaphragm air pump for collecting air samples, a collecting tube, a container for collecting low pressure air and an OLED display with a 12C interface for displaying the collected data.
Patent RO-137117-A0 (RO)
Title: Process for generating electrical energy in urban and rural agglomerations along water streams
Inventor: TOTH SZILARD KRISZTIAN
IPC: F03D3/02
Filed: 2022-07-07
Abstract: The invention relates to a process for generating electric energy in urban and rural agglomerations along the stream of non-conventional waters or in any fluid transport networks. According to the invention, the process consists in studying the plans of the existing networks and in mounting systems for generating electric energy to obtain thereby a non-polluting technology to achieve a partial de-pollution of waste water, this way contributing to the energy independence of the region where it operates, the device for generating electric energy being installed next to the sewage network or other underground fluid transport networks, where the ancillary installations will also be installed, this way new energy production facilities will be installed within the networks that transport fluids by gravity, for which purpose the facilities for producing electric energy are installed, the process ending with the injection of the obtained electric energy into the national electric power grid, or the energy sale to customers.
Patent IE-900222-A1 (IE)
Title: Therapeutic peptides
IPC: C07K/
Filed: 1990-01-19
Abstract: In general, the invention features a linear (i.e., non-cyclic) bombesin analog of biologically active mammalian gastrin-releasing peptide (GRP) and amphibian bombesin, having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell; cleavage of a peptide bond in the active site of naturally occurring bombesin or GRP is unnecessary fcr in vivo biological activity. The analog has one of the following modifications; (a) a deletion of a residue within the active site and a modification of a residue outside of the active site, or (b) a replacement of one or two residues within the active site with a synthetic amino acid, The analog is capable of binding to the receptor and acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of one of the modifications, failing to exhibit the in vivo biological activity of the naturally occurring peptide.
Patent LU-85398-A1 (LU)
Inventor: CORSETTE DOUGLAS F
IPC: B65D83/76
Filed: 1984-06-06
Abstract: A dispensing pump is adapted for pressure filling and includes a fluid filling passage which remains sealingly closed during pumping operation by the provision of an annular valve skirt in sealing engagement with a wall of the fluid filling passage, such skirt inwardly flexing during charging the container permitting the charged fluids to by-pass the valve and enter the container. The valve skirt depends from either the plunger head or from the plunger. When depending from the plunger, the valve skirt functions as a guide element for the plunger head together with a plunger head retention bead which cooperates with a pump body retention bead in limiting the upward movement of the plunger head to a predetermined extent. These guide members serve to isolate the plunger against the influence of lateral or eccentric forces applied against the plunger head during its reciprocation. And, the plunger may be capped with a wall surface defining a complementary contour to that of the upper end of the piston which it faces to facilitate expelling of product from the accumulation chamber after the end of the plunger downstroke as this surface first bottoms against the upper end of the piston.
Patent MA-25102-A1 (MA)
Title: Commutateur de paquets pour un reseau en mode de transfert asynchrone
Inventor: CHAS ALONSO PEDRO LUIS
IPC: H04L12/54
Filed: 2000-04-18
Abstract: LE COMMUTATEUR DE PAQUETS POUR LE RÉSEAU EN MODE DE TRANSFERT ASYNCHRONE EST L'ÉLÉMENT DE BASE D'UNE MATRICE DE COMMUTATION  ATM, DONT LA MISSION EST DE COMMUTER DES PAQUETS DE  8, 12  OU  2O MOTS DE 4 BITS, APPELÉS MICRO-CELLULES,  ORGANISÉS EN TRAMES. IL POSSèDE HUIT ENTRÉES QUATRE SORTIES,  RAISON POUR LAQUELLE SI L'ON VEUT CONSTRUIRE UN ÉLÉMENT DE BASE DE COMMUTATION DE HUIT ENTRÉES ET HUIT SORTIES ONT UNIT LES ENTRÉES DE DEUX CIRCUITS COMMUTATEURS DE PAQUETS. POUR LA COMMUTATION,  EN FONCTION DE L'ENTeTE DES MICRO-CELLULES à L'ENTRÉE,  SE DIRIGENT VERS UNE SORTIE DÉTERMINÉE.  EN  PLUS ON ÉVITE DES PERTES D'INFORMATION ET DES PROBLèMES DE CONTENTION DE CES MICRO-CELLULES AVEC UN ALGORITHME DE SÉLECTION ET DES QUEUE à LA SORTIE DU CIRCUIT COMMUTATEUR.  IL POSSèDE AUSSI SYNCHRINISATION AUTOMATIQUE ENTRE LA MONTRE DES DONNÉES ET CELUI DU SYSTèME ET DE TÉTECTION DES ERREURS.
Patent MA-38434-A1 (MA)
Title: Article à fumer électronique
Inventor: PLUNKETT SUSAN E
IPC: A24F40/50
Filed: 2014-02-20
Abstract: L'invention concerne un article à fumer électronique qui comprend une région d'alimentation en liquide comprenant une matière liquide et un élément mèche d'élément chauffant conçu pour aspirer la matière liquide et pour chauffer celle-ci à une température suffisante pour évaporer la matière liquide et former un aérosol. L'élément mèche de l'élément chauffant est formé d'une mousse de carbone ou de graphite.
Patent UY-23772-A1 (UY)
Inventor: ROLF E ROLAND
IPC: B09B3/00
Filed: 1994-05-06
Abstract: A method and apparatus for comminuting and sterilizing infectious waste wherein the size reduction processes take place within the same sealed container within which the sterilization through vacuumization and saturated steam pressurization takes place. Between the vacuum cycle and the high-pressure steam cycle there is interposed an intermittent steam pressurization step to atmospheric pressure. The comminution of infectious waste material is carried out by a series of cutting, crushing and shearing elements which are arranged in a compact, stack-like fashion in a vertical arrangement with the bearing elements, clutch, gear and motor located outside the autoclave container and detachable therefrom, which allows ready access to the shredder stack which can be removed and exchanged in fully assembled fashion.
Patent UY-25205-A1 (UY)
Title: Grupo de erogación para una máquina dispensadora de productos fluidos, que comprende una cámara bombeadora de volumen variable, y máquina que comprende tal grupo de erogación.
Inventor: ANDREA PARRINO
IPC: G05D11/035
Filed: 1998-10-09
Abstract: Un grupo de erogación para una maquina dispensadora de productos fluidos comprende al menos un conducto de entrada y uno de salida para un producto fluido, que comunican con una cámara bombeadora de volumen variable, que comprende al menos una pared flexible. En los conductos de entrada y de salida, se han dispuesto dos válvulas respectivas de no retorno que entre si están en contrafase. La cámara bombeadora esta acoplada a medios actuadores que comprenden un motor paso a paso y un grupo de tornillo-rosca y un carro. El carro proporciona movimiento a la cámara bombeadora desde una oposición de cero en la que la cámara tiene un volumen máximo. Máquina dispensadora de productos fluidos, que comprende al menos un inyector de erogación de un producto fluido, que se caracteriza por el hecho de que comprende al menos grupos de erogación, desembocando los conductor de salida de los grupos de erogación por el exterior de la maquina en correspondencia con al menos un inyector. Dicha máquina dispensadora se caracteriza por el hecho de que el grupo de control comanda el movimiento de la cámara bombeadora con velocidades diferentes en la carrera hacia el punto de cero y hacia el punto de final de carrera, respectivamente.
Patent UY-26891-A1 (UY)
Title: Nuevos derivados del aminociclohexano
Inventor: WALLBAUM SABINE
IPC: C07D233/84
Filed: 2001-08-15
Abstract: La presente invención se refiere a compuestos de la fórmula (I); los compuestos son útiles para el tratamiento y/o prevención de enfermedades asociadas con la 2,3-oxidoescualeno-lanosterol ciclasa como la hipercolesterolemia, hiperlipemia, arteriosclerosis, enfermedades vasculares micosis, cálculos biliares, tumores y/o trastornos hiperproliferativos, y el tratamiento y/o la prevención de la tolerancia a glucosa deficiente y la diabetes.
Patent UY-27755-A1 (UY)
Title: Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores.
Inventor: JUNG BIRGIT
IPC: A61K31/517
Filed: 2003-04-09
Abstract: La presente invención se refiere a nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores de la p 38 quinasa, a procedimientos para prepararlas y a su uso en el tratamiento de enfermedades respiratorias.
Patent UY-27827-A1 (UY)
Title: Composiciones y su uso terapeutico
Inventor: AL-SARI MISHAL HAMID
IPC: A61K31/375
Filed: 2003-05-28
Abstract: La presente invención se basa en el descubrimiento sorprendente de que el uso de uno o más productos naturales, es decir materiales que están presentes en el cuerpo in vivo o que al menos son bien tolerados por él, son efectivos en el tratamiento de las enfermedades del tipo descrito anteriormente
Patent UY-28581-A1 (UY)
Title: Compuestos nucleosidicos para el tratamiento de infecciones virales
Inventor: ROBERTS CHRISTOPHER DON
IPC: C07H19/14
Filed: 2004-10-26
Abstract: Compuestos, composiciones y métodos para el tratamiento de infecciones virales causadas por un virus de la familia Flaviviridae, tal como el virus de la hepatitis C.
Patent UY-29740-A1 (UY)
Title: Formulaciones de disoluciones de hfc que contienen hidrocloruro de salbutamol o citrato de salbutamol
Inventor: SCHMIDT FRIEDRICH
IPC: A61K31/137
Filed: 2006-08-11
Abstract: Formulaciones de disolución para aerolol estabilizadas que contienen sales de edicinon de ácido de salbutamol, adecuadas para sua administración poe inhaladores de dosis medidas (los MDI).Formulaciones de una disolición que contiene un a de la sales mencionadas anteriormente de salburamol, preferiblemente hidroclururo de dalbutamolo citrato de salbutamol, más preferiblemente una de dicha sales en combinación con una o más sustancias farmacológicamente activas adicionales, junto con un hidrofluorocabono (HFC) medioambientalmente seguro como propelente, un disolvente conjunto, preferiblemente un compuesto orgánico como disolvente conjunto y bién un ácido inorgánico o un ácido orgánoco.
Patent UY-29975-A1 (UY)
Title: Composiciones a base de omeprazol o esomeprazol o sus sales, y a base de acido acetilsalicilico, procedimientos para la preparación de las mismas y aplicaciones.
Inventor: SVEDBERG LARS-ERIK
IPC: A61K31/4439
Filed: 2006-11-29
Abstract: La invención comprende : - Preparción farmacéutica oral para uso en la prevención y/o reducción de complicaciones gastrointestinales vinculadas al uso del ácido acetilsalicílico. - Forma de dosificación oral fija conteniendo un inhibidor de la bomba de protones en combinación con ácido acetilsalicílico. - Método para su fabricación y utilización medicinal. - Combinación específica conteniendo esomeprazol, o sal alacalina del mismo o forma hidratada de cualquiera de ellos, y ácido acetilsalicílico para uso como medicamento para prevención de eventos vasculares tromboembólicos, como infarto de miocardio o apoplejía, y para la prevención/reducción de complicaciones gastrointestinales vinculadas al uso de ácido acetilsalicílico.
Patent DZ-1752-A1 (DZ)
Inventor: NOUAIL GERARD
IPC: F16L58/04
Filed: 1994-02-13
Granted: 2002-02-17
Abstract: A cast iron piping system element has an outer coating comprising a first, inner porous layer consisting of zinc/aluminum alloy containing from 5 to 60% of aluminum, and a second, outer pore occluding layer of an organic or mineral binder in an aqueous, solvent or powder phase with a thickness of 100-140  mu m.