Patent SG-11201810576Q-A (SG)
Title: New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
Inventor: Kotschy András 
IPC: C07D495/04
Filed: 2017-06-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 011101111011111M1111111011MMIR1111111111110 III 1111 III1 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/212010 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 471/04 (2006.01) A61K 31/519 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, CO7D 487/04 (2006.01) A61P 35/00 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, C07D 495/04 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (21) International Application Number: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PCT/EP2017/064062 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (22) International Filing Date: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 09 June 2017 (09.06.2017) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (30) Priority Data: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 16/55387 10 June 2016 (10.06.2016) FR EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 16/63463 28 December 2016 (28.12.2016) FR MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicants: LES LABORATOIRES SERVIER KM, ML, MR, NE, SN, TD, TG). [FR/FR]; 35 me de Verdun, 92284 SURESNES (FR). VERNALIS (R&D) LIMITED [GB/GB]; 100 Berkshire Published: Place, Wharfedale Road, WINNERSH, Berkshire RG41 5RD (GB). — with international search report (Art. 21(3)) Inventors: KOTSCHY, Andras; Almos Vezer utca 4, = (72) 2045 Torokbalint (HU). WEBER, Csaba; Szentendrei ut- _ ca 9, 2009 Pilisszentlaszlo (HU). VASAS, Attila; Eori Bar- = - na u. 65, 2151 Fot (HU). MOLNAR, Balizs; Fenyves ut- ca 3, 2117 Isaszeg (HU). KISS, Arpad; Filst Milan utca 6, 3/10, 1039 Budapest (HU). MACIAS, Alba; 12 Beaulands = = Close, Cambridge, Cambridgeshire CB4 1JA (GB). MUR- _ RAY, James Brooke; 21 Parsonage Way, LINTON, Cam- bridgeshire CB21 4YL (GB). LEWKOWICZ, Elodie; 93 —= avenue Denfert Rochereau, 75014 Paris (FR). GENESTE, — Olivier; Batiment A, 17, me Crevel Duval, 92500 RUEIL MALMAISON (FR). CHANRION, Maya; 14 rue de la = Galiote, Apt D441, 92130 ISSY LES MOULINEAUX = = — (FR). DEMARLES, Didier; 21 me du Lievre, 45430 = CHECY (FR). IVANSCHITZ, Lisa; 25 avenue Reille, 75014 PARIS (FR). = (81) Designated States (unless otherwise indicated, for every = kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = = (54) Title: NEW (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Il O H A rna 2111 l'' © Il W — C H ,.............„.\".„/„. .,,, , -\"s. N / j `s, K .- -L 0 ei 0) 1-1 ei N IN ,-1 o R i © ei 0 (57) : Compounds of formula (I) wherein R1, R2, J, K, L, n and W are as defined in the description. Medicaments.