baber/WOPTO huggingface dataset:
Patent NZ-527009-A (NZ)
Title: 2-Arylamino-pyrimidines for the treatment of GSK3-related disorders
Inventor: BERG STEFAN
IPC: A61K31/727
Filed: 2002-02-18
Abstract: Use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of conditions associated with glycogen synthase kinase-3 inhibition.
Patent NZ-527391-A (NZ)
Title: Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
Inventor: SURLERAUX DOMINIQUE LOUIS NEST
IPC: A61K31/5377
Filed: 2002-02-14
Abstract: Compounds having the formula (I), N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein: R1 and R8 each are H, optionally substituted C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6 alkyl; L is -C(=O)-, -O-C(=O)-, -NR8-C(=O)-, -O-C1-6 alkanediyl-C(=O)-, -NR8-C1-6 alkanediyl-C(=O)-, -S(=O)2-, -O-S(=O)2-, -NR8-S(=O)2; R3 is C1-6 alkyl, aryl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4 alkyl, or arylC1-4 alkyl; R4 is H, C1-4 alkylOC(=O), carboxyl, aminoC(=O), mono- or di(C1-4 alkyl)aminoC(=O), C3-7 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl or optionally substituted C1-6 alkyl; A is C1-6 alkanediyl, -C(=O)-, -C(=S)-, -S(=O)2-, C1-6 alkanediyl-C(=O)-, C1-6 alkanediyl-C(=S)- or C1-6 alkanediyl-S(=O)2-; R5 is H, OH, C1-6 alkyl, Het1C1-6 alkyl, Het2C1-6 alkyl, optionally substituted aminoC1-6 alkyl; R6 is C1-6 alkylO, Het1, Het1O, Het2, Het2O, aryl, arylO, C1-6 alkyloxycarbonylamino or amino; and in case -A- is other than C1-6 alkanediyl then R6 may also be C1-6 alkyl, Het1C1-4 alkyl, Het1OC1-4 alkyl, Het2C1-4 alkyl, Het2OC1-4 alkyl, arylC1-4alkyl, arylOC1-4alkyl or aminoC1-4alkyl; whereby each of the amino groups in the definition of R6 may optionally be substituted; R5 and -A-R6 taken together with the nitrogen atom to which they are attached may also form Het1 or Het2. These use of the compounds of formula (I) as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them is also disclosed, as well as combinations thereof with another anti-retroviral agent, and their use in assays as reference compounds or as reagents.
Patent NZ-531699-A (NZ)
Title: Stabilizing cap for dual-compartment adhesive dispensing cartridge
Inventor: TIMMERMAN MARK S
IPC: B65D81/32
Filed: 2004-03-11
Abstract: A dual-compartment adhesive dispensing cartridge comprises a pair of storage compartments (112, 114) for containing two different reactive components of, for example, an adhesive mixture. A pair of dispensing conduits (122, 124) are defined within a dispensing outlet portion (118) by means of a divider wall (120) which extends through the entire axial extent of the dispensing outlet portion so as to ensure that the two reactive components are maintained separate until the components are to be dispensed. A cap member (130) comprises a pair of dependent plugs (136, 138), and the cap member is initially integrally secured upon the upper end portion of the dispensing outlet portion by means of peripheral frangible connections (140, 142) which are defined between the plugs and the upper end portions of the dispensing conduits which define dispensing outlet ports (126, 128). In addition, an axially oriented web member (144) extends upwardly from a central region of the dispensing outlet portion, and the cap member is integrally secured to the upper extremity of the web member by means of another frangible connection (146). In this manner, when the cap member (130) is to be separated from the dispensing cartridge, the integral connection defined between the cap member (130) and the web member (144) effectively serves as a pivotal fulcrum about which the cap member can be pivoted so as to impress tension and compression forces upon the frangible plug connections (140, 142) and thereby cause the clean and accurate fracture of the frangible plug connections so as to cleanly and fully uncover the dispensing outlet ports (126, 128).
Patent NZ-537354-A (NZ)
Title: Inflatable multi-function parabolic reflector apparatus and methods of manufacture
Inventor: ESSIG JOHN R
IPC: F24S20/30
Filed: 2002-05-30
Abstract: An inflatable, multifunction, multipurpose, parabolic reflector apparatus having a plurality of manufactured parabolic mirrors (14, 16) made from a pressure-deformable reflective covering of an inflatable ring (12) for focusing electromagnetic energy from radio frequency radiation (RF) through the ultraviolet radiation (UV) and solar energy for (1) heating and cooking, for (2) electrical power generation, for (3) enhancing the transmission and reception of radio signals, for (4) enhancing vision in low-light environments, and for (5) projection optical signals or images. The device also has non-electromagnetic uses, such as the collection of water. A first main embodiment utilizes two reflective membranes (14, 16). A second main embodiment utilizes a reflective membrane and a transparent membrane. Portability is enhanced by complete collapsing of the inflatable device.
Patent NZ-537849-A (NZ)
Title: Direct Retinal Display projecting a scanned optical beam via diverging and converging reflectors
Inventor: HILTON PETER JAMES
Filed: 2005-01-21
Abstract: A direct retinal display (50) for displaying an image on the retina of an eye (62) with a wide field of view is disclosed. The direct retinal display (50) comprises a scan source (52) that is arranged to generate a scanned optical beam (58) in two dimensions over a scan angle in each dimension. The scanned optical beam is modulated with an image. The direct retinal display (50) further comprises a diverging reflector (54) in the path of the scanned optical beam (58) that is arranged to asymmetrically reflect the scanned optical beam (58) incident on the diverging reflector (54) outwardly with a substantially magnified scan angle. A converging reflector (56) in the path of the reflected scanned optical beam is arranged to reflect the scanned optical beam, having a substantially magnified scan angle, substantially toward a convergence spot at the pupil (60) of the eye (62) for reconstruction and display of the image on the retina with a wide field of view.
Patent NZ-540258-A (NZ)
Title: Nutraceutical compositions comprising epigallocatechin gallate and raspberry ketone
Inventor: RAEDERSTORFF DANIEL
IPC: A23L27/12
Filed: 2003-11-20
Abstract: A nutraceutical composition comprises epigallocatechin gallate (EGCG) and 4- (4-hydroxyphenyl)-2- butanone (RK) for the treatment or prevention of obesity or conditions associated with obesity such as non-insulin-dependent diabetes mellitus (NIDDM, type II) and syndrome X.
Patent NZ-541216-A (NZ)
Title: Thienopyridazinone derivatives as modulators of autoimmune diseases
Inventor: COOPER MARTIN EDWARD
IPC: C07D/
Filed: 2004-01-15
Abstract: Disclosed is a compound of formula (I), wherein R3 is a group CO-G or SO2-G and the remaining substituents are as defined in the specification. The compounds are inhibitors of T-cell proliferation and are useful in the modulation of autoimmune disease.
Patent NZ-542210-A (NZ)
Title: Methods and compositions for the treatment and prevention of staphylococcus and other bacterial infections
Inventor: BALABAN NAOMI
IPC: A61K38/08
Filed: 2004-01-30
Abstract: Provided is a method of preventing or treating an infection caused by any bacterial species of the Bacillaceae family in which RNAIII-activating protein (RAP) plays a role in pathogenesis, comprising administering to a non-human subject an amount of a RAP polypeptide effective to elicit an antibody response in the subject to prevent or treat said infection. Further provided are similar methods utilizing TRAP and RIP proteins and use of the proteins in the manufacture of a medicament to treat bacterial infections.
Patent NZ-544407-A (NZ)
Title: Conjugated complement cascade inhibitors
Inventor: SUBASINGHE NALIN
IPC: A61K47/48
Filed: 2004-06-18
Abstract: Disclosed is the compound of formula (I) wherein X is C or N; R1 is -NH(C=O)NH-PEG-OCH3 or -NH(C=O)NH(CH2)n(C=O)NH-PEG-OCH3 ; R2 is ureido or guanidino; R3 is C1-4 alkyl; and PEG is a polyethylene glycol having a molecular weight of 20-40 K; and the pharmaceutically acceptable salts thereof.
Patent NZ-548283-A (NZ)
Title: Electromagnetic treatment apparatus and method
Inventor: PILLA ARTHUR
IPC: A61N2/02
Filed: 2004-12-04
Abstract: An electromagnetic treatment apparatus suitable for plants and animals comprises: a waveform configuration means (201) for configuring at least one waveform having at least one waveform parameter and a coupling device (203) connected to the waveform configuration means (201) by at least one connecting means (202) for generating an electromagnetic signal from the configured at least one waveform and for coupling the electromagnetic signal to the target pathway structure. A value of the at least one waveform parameter is chosen by using a constant of the target pathway structure to evaluate a signal to noise ratio to compare voltage induced by the at least one waveform in the target pathway structure to baseline thermal fluctuations in voltage and electrical impedance in the target pathway structure. The bioeffective modulation occurs in the target pathway structure by the at least one waveform by maximizing the signal to noise ratio within a bandpass of the target pathway structure.
Patent NZ-551508-A (NZ)
Title: Adamantyl-acetamide derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
Inventor: LINK JAMES T
IPC: C07D213/74
Filed: 2005-04-29
Abstract: Disclosed is a compound according to formula (I) wherein A1 is alkyl-NH-alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, arylcarbonyl, arylsulfonyl, heterocyclecarbonyl, heterocyclesulfonyl, arylalkyl, aryloxyalkyl, carboxyalkyl, carboxycycloalkyl, haloalkyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, -NR7-[C(R8R9)]n-C(O)-R10, -O-[C(R11R12)]p-C(O)-R13, -N(R15R16), -CO2R17, -C(O)-N(R18R19), -CR20R21)-OR22, or -C(R23R24)-N(R25R26); and wherein the rest of the substituents are disclosed within the specification. Also disclosed is the use of a compound of formula (I) in the manufacture of a medicament for treating a disorder associated with the inhibition of 11-beta-hydroxysteroiddehydrogenase type 1 enzyme selected from Cushing's syndrome, non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, hypertension, atherosclerosis, glaucoma, and osteoporosis.
Patent NZ-554223-A (NZ)
Title: A method and system for assessing a musical performance
Inventor: EVANS DAVID
IPC: G06F3/16
Filed: 2005-01-31
Abstract: The performance of a musical instrument is assessed on its relation to a model performance of the same composition but performed by a different musician. As even a model performance does not follow a score of a composition precisely, the model performance is initially correlated to corresponding score. This allows for an accurate assessment of the timing of the assessable performance, relative to the timing of the model performance. The technique is of particular use where the assessable performance is performed along with the model performance, but the two performances are remote from each other.
Patent NZ-555003-A (NZ)
Title: Solid drug for oral use comprising indoline compound
Inventor: NAGANUMA TSUYOSHI
Filed: 2003-12-11
Abstract: Disclosed is a tablet which comprises: (1) a granular material containing a) as an active ingredient, a compound represent by the formula 1, b) D-mannitol, c) low substituted hydroxylpropylcellulose, and d) hydroxypropylcellulose, and (2) a lubricant selected from magnesium stearate, calcium stearate or talc, Wherein 85% dissolution time is note more than 60 minutes in a dissolution test according to method 2 (paddle method) of Japanese pharmacopoeia in a condition using water as a test medium and a paddle speed of 50 rpm.
Patent NZ-560922-A (NZ)
Title: Cable winch operated vehicle mounted tipping deck
Inventor: WILSON RICHARD
Filed: 2007-08-27
Abstract: A vehicle deck tipping mechanism operated by a winch and cable is disclosed. The deck (1) is connected to the vehicle (1) at a pivot point (3) and sliding struts (4) on either side of the deck can apply a force to tip the deck about the pivot point. A winch drives a main cable that is connected to the centre of a secondary cable (10). The secondary cable passes through a guide system and is connected at its ends to the slide ends of the struts. When the main cable is pulled, the secondary cable moves the ends of the struts along their slide guides (7) to raise the deck. The greatest mechanical advantage is achieved during the initial movement of the main cable, when the torque required to tip the deck about the pivot point is highest. As the main cable is pulled, the angle between the main and secondary cables increases and so the mechanical advantage through the cable system decreases.
Patent NZ-562125-A (NZ)
Title: Compounds and intermediates for the preparation of asenapine
Inventor: KEMPERMAN GERARDUS JOHANNES
IPC: C07D313/14
Filed: 2006-04-06
Abstract: Disclosed is a process for preparing asenapine of formula A or a salt thereof, the process comprising: (a) cyclising a trans-amino acid derivative of formula I or formula II or a salt thereof, to give a lactam of formula IV or formula VII; (b) reducing the carbonyl moiety of a lactam of formula IV or formula VII to give the asenapine of formula A; and (c) optionally converting the asenapine of formula A to a salt thereof. Also disclosed is a process of preparing the intermediates (I) and (II). A one pot process for preparing asenapine of formula A from the compounds of the formulae (I) or (II) is also disclosed.
Patent NZ-562958-A (NZ)
Title: Wood knot detecting method, device, and program
Inventor: HIRAOKA NORIYUKI
IPC: G06V10/44
Filed: 2006-04-28
Abstract: A method executed by a programmed processor for searching knots in wood is disclosed. The method comprises photographing a piece of wood by a photographing unit; performing a first calculation comprising calculating degrees of circularity of each figure in the photographed images of the piece of wood and setting at least one figure comprising a circularity corresponding to a knot candidate; clipping a partial image including the knot candidate from the at least one figure and varying threshold levels of gray value for the clipped partial image such that an image is obtained at each of the threshold levels. The image includes the knot candidate. The method further includes performing a second calculation comprising calculating a degree of circularity and stability of the knot candidate at each of the threshold levels and identifying one of the images from the plurality of images comprising a selected threshold level. The selected threshold level corresponds to a level at which the circularity and the size stability of the knot candidate is a maximum value with respect to the circularity and the size stability values of the knot candidate in the other images. The method further includes determining a configuration of the knot candidate at the selected threshold level and detecting the knot candidate as a knot when the degree of the circularity of the knot candidate is greater than a predetermined circularity degree at the selected threshold level. An apparatus for searching for knots in wood comprising a photographing unit for photographing pieces of wood and an image processing unit programmed to carry out the above described method is also disclosed.
Patent NZ-569035-A (NZ)
Title: Manifold for use in medicament dispenser with bleed hole(s) between chamber and chimney to disrupt airflow
Inventor: DAVIES MICHAEL BIRSHA
IPC: A61M15/00
Filed: 2006-12-11
Abstract: There is provided a manifold (450) for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, said body defining a chimney (452) having a chimney inlet (453) and a chimney exit for directing airflow (485) from said chimney inlet to said chimney exit; the body further defining a chamber (460) having a chamber inlet (473b) and a chamber exit (474). The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow (485) may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber exit. One or more bleed holes (480) are provided between the chimney and the chamber such that bleed airflow (486) may be directed into the chamber to disruptively impact the airflow (485) that transports the entrained medicament powder.
Patent NZ-569293-A (NZ)
Title: Modified lysine-mimetic compounds
Inventor: LARSEN BJARNE DUE
IPC: C07D207/50
Filed: 2006-12-21
Abstract: The disclosure relate to lysine mimetic compounds of formula (III) having pharmacological activity, such as antiarrhythmic activity, and desirable bioavailability properties, wherein the variables shown in the structure of foemula (III) are as defined in the specification. The present teachings further relate to pharmaceutical compositions comprising such compounds and methods of using and making such compounds and compositions for the prevention or treatment of a pathological condition selected from cardiovascular disease; osteoporosis; inflammation of airway epithelium; disorders of alveolar tissue; bladder incontinence; impaired hearing; endothelial lesions; Type I or Type II diabetes; diabetic retinopathy; diabetic neuropathy; atherosclerosis; CNS related conditions; seizures; ischemia; dental tissue disorders; kidney diseases; anaemia; leukopenia; thrombocytopenia; pancytopenia; superficial wounds; deep wounds resulting from trauma; bone fractures; erectile dysfunction; urinary bladder incontinence; neuropathic pain; subchronic and chronic inflammation; cancer; failure of bone marrow; stem cell transplantation; conditions arising during transplantation of cells and tissues; conditions arising during medical procedures; conditions caused by an excess of reactive oxygen species, free radicals or nitric oxide; diseases or disorders of pregnancy; female infertility or stroke.
Patent NZ-570010-A (NZ)
Title: Devices, systems and methods for determining sizes of vessels
Inventor: KASSAB GHASSAN S
IPC: A61B5/107
Filed: 2007-01-25
Abstract: A device for determining a cross sectional size of a vessel is disclosed. The device comprises: an elongated body having a longitudinal axis extending from a proximal end to a distal end, where the body has a surface configured for introduction of the distal end into a lumen of a vessel; first and second excitation electrodes along the longitudinal axis, where both electrodes are located in respective subsurface grooves near the distal end; and first and second detection electrodes located in respective subsurface grooves along the longitudinal axis and in between the first and second excitation electrodes. The respective subsurface grooves are structured to prevent contact between the detection and excitation electrodes and a conductive object above the surface of the body. At least one of the first and second excitation electrodes is in communication with a current source enabling a supply of electrical current to the vessel to enable measurement of two or more conductance values in the vessel by the detection electrodes, thereby enabling calculation of parallel tissue conductance in the vessel. Tissue conductance is the inverse of resistance to current flow, which depends on the cross sectional area of the vessel.
Patent NZ-570549-A (NZ)
Title: A pump system having an electric motor driving a positive displcement pump and a cutter, a current sensor is provided which stops motor operation if measured motor current exceeds a threshold, and reverses the motor a predetermined amount
Inventor: MOORE ANDREW
IPC: E03F1/00
Filed: 2008-08-15
Abstract: A pump system for use in a pressure sewer system, and a method of controlling a pump system, is disclosed. The pump system comprises a positive displacement pump, a cutter, and an electric motor configured to drive the pump and the cutter. The pump system further comprises a current sensor configured to measure the electric current provided to the motor and a controller configured to monitor the electric current measured by the current sensor during operation of the pump system. In operation, if the measured electric current exceeds a predetermined threshold, the controller stops the operation of the motor and reverses the motor by a predetermined.
Patent NZ-575650-A (NZ)
Title: Pyrimidinopyrazole derivatives as inhibitors of Bruton's tyrosine kinase
Inventor: HONIGBERG LEE
IPC: A01N43/90
Filed: 2006-12-28
Abstract: Disclosed are pyrazolo-pyrimidin derivatives of formula (D) that form covalent bonds with Bruton's tyrosine kinase (Btk), wherein the variables shown in the structure of formula (D) are as defined in the specification. Also described are irreversible inhibitors of Btk; methods for the preparation of these compounds; and pharmaceutical compositions that include the compounds. These Btk inhibitors are suitable for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Patent NZ-576233-A (NZ)
Title: System and method for positioning a stent graft
Inventor: GODDARD ROBERT WILLIAM
IPC: A61F2/95
Filed: 2007-10-15
Abstract: Disclosed is a system for positioning in vivo a tubular stent graft having first and second ends at either end of a bore, the system comprising a first positioner for releasable attachment to the stent graft closer to the first than to the second end, a second positioner for releasable attachment to the stent graft closer to the first than to the second end, a flexible link for releasably attaching at least one of the first and second positioners to the stent graft, means for controlling the position of the first and second positioners, a first connector connecting the first positioner to said means for controlling, and a second connector connecting the second positioner to said means for controlling, wherein one of the first and second positioners can extend beyond said first end to provide a turning point which can be used to pull the stent graft in one direction, the other positioner pulling the stent graft in the other direction in order to provide a turning couple.
Patent NZ-576501-A (NZ)
Title: Pyridine carboxamides as 11-beta-hsd1 inhibitors
Inventor: MCCOULL WILLIAM
IPC: A61K31/44
Filed: 2007-10-31
Abstract: Provided is a compound of Formula (1) with specified substituents. The compound is useful in treating metabolic syndrome, diabetes, obesity and atherosclerosis and has an 11betaHSD1 inhibitory effect in warm-blooded animals.
Patent NZ-577037-A (NZ)
Title: Apparatus and method for producing porous filter membranes by co-extrusion
Inventor: ERSKINE GILBERT
IPC: B01D67/00
Filed: 2007-06-13
Abstract: The present disclosure relates to an apparatus and method of producing lengths of multi-layered asymmetric membrane (10) by way of extruding different feedstock through a die head (46) having a plurality of outlet ports. The membrane (10) includes a plurality of apertures extending therethrough, and at least some of said apertures increase in cross-sectional area from a first surface of the membrane to a second surface of the membrane. The present disclosure provides a method of constructing membrane in desired lengths and reduces the need to weld portions of membrane together to produce extended lengths of membrane tube.