Patent SG-11201804133P-A (SG)
Title: Modulators of chemokine receptors
Inventor: CHEN XI
IPC: C07C225/20
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau irst0) (43) International Publication Date .... ....r .....1 26 May 2017(26.05.2017) WIPO I PCT ID Hit (10) WO International 2017/087607 111111111111111111IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIIIIIIIIII Publication Al Number (51) International Patent Classification: Rajinder; 1832 Hillman Avenue, Belmont, CA 94002 A61K 31/341 (2006.01) CO7C 225/20 (2006.01) (US). TANAKA, Hiroko; 600 Rainbow Drive, #148, Mountain View, CA 94041 (US). YANG, Ju; 966 Clara (21) International Application Number: Drive, Palo Alto, CA 94303 (US). YU, Chao; 555 E. PCT/US2016/062417 Washington Avenue, Apt. 1105, Sunnyvale, CA 94086 (22) International Filing Date: (US) ZHANG, Penglie; 1036 Jamaica Street, Foster City, 17 November 2016 (17.11.2016) CA 94404 (US). (25) Filing Language: English (74) Agents: KEZER, William, B. et al.; Mintz Levin Cohn Ferris Glovsky and Popeo, P.C., One Financial Center, Bo - (26) Publication Language: English ston, MA 02111 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/257,389 19 November 2015 (19.11.2015) US kind of national protection available): AE, AG, AL, AM, 62/277,711 12 January 2016 (12.01.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (71) Applicant: CHEMOCENTRYX, INC. [US/US]; 850 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Maude Avenue, Mountain View, CA 94043 (US). DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (72) Inventors: CHEN, Xi; 1198 Beech Street, E. Palo Alto, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, CA 94303 (US). DRAGOLI, Dean, R.; 24645 Summerhill MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, Avenue, Los Altos, CA 94024 (US). FAN, Junfa; 2492 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Wilkie Way, #H, Palo Alto, CA 94306 (US). KALISIAK, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, Jaroslaw; 1031 Crestview Drive, Apt. 104, Mountain TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, View, CA (US). KRASINSKI, Antoni; 746 W. Knicker- ZW. bocker Drive, Sunnyvale, CA 94087 (US). LELETI, Man- Reddy; 7269 Ventana Drive, San Jose, CA 95129 (84) Designated States (unless otherwise indicated, for every mohan, kind ARIPO GH, MALI, Venkat; 20800 Valley Green Drive, #427, of regional protection available): (BW, (US). Cupertino, CA 95014 (US). MCMAHON, Jeffrey; 15 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Alta Mar Way, San Francisco, CA 94121 (US). SINGH, [Continued on next page] (54) Title: MODULATORS OF CHEMOKINE RECEPTORS FIGURE 4 Thickness, erythema and scaling scores >3 in mice treated with Compound 1.129 compared to vehicle treated mice in the imiquimod induced model psoriasis . ., Thickness Erythema Scaling . loe 100 . boa i 0 a* ea • a El so : 90 . \"0 \": 4 • If 5 ge N\%. 5 a 5 4 ° i n 1 20 N Z. i 2 n E ! E .\" :NYIN, • .. c , , „, , ^^\" , As , is ti i • • .a ° R5b 0 P a l Rya1 < .4t IN O R 6a n N / N R 4 GC 0 IN Il (57) : Compounds are provided as chemokine R 6b NR \ H H B (A) inhibitors having the structure: Fot tula (A). 0 ei O WO 2017/087607 Al MIDEDIMOHNIIMMENMEIHINIERVOIMIE TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Published: DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, LT, SE, GA, — with international 21(3)) search report (Art. GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).