baber/WOPTO huggingface dataset:
Patent NZ-547277-A (NZ)
Title: Substituted quinolines and their use as mycobacterial inhibitors
Inventor: GUILLEMONT JEROME EMILE GEORGE
IPC: C07D413/14
Filed: 2005-01-21
Abstract: Disclosed are substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N--oxide forms thereof, wherein: - R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; - p is 1, 2, 3 or 4; - R2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula (Ic); - R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; - R4 is hydrogen, alkyl or benzyl; - R5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl, or two vicinal R5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; - r is 1, 2, 3, 4 or 5 ; - R6 is hydrogen, alkyl, Ar or Het R7 is hydrogen or alkyl; R8 is oxo ; or R7 and R8 taken together form the radical - CH=CH-N=; Z is CH2 or C(=O). The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as M. tuberculosis, M. bovis, M. avium, M. smegmatis and M. marinum. Also claimed is a pharmaceutical composition containing a compound of the present invention, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.
Patent NZ-552036-A (NZ)
Title: Novel compounds having an anti-bacterial activity
Inventor: PIERAU SABINE
IPC: A61K31/445
Filed: 2005-08-25
Abstract: The disclosure relates to anti-bacterial naphthyridin derivative compounds of formula (I) Q-NH-CO-R3 wherein Q is a group having the structure shown herein and the variables R1, X1, X2, X3, X4, X5 & X6 are as defined in the specification. These compounds are inhibitors of DNA gyrase and are suitable for treating bacterial infections.
Patent NZ-555814-A (NZ)
Title: Continuously casting steel strip
Inventor: COOPER W KENT
IPC: B22D11/06
Filed: 2005-11-21
Abstract: A method of producing thin cast steel strip 12 by continuous casting with lessened downtime during a casting campaign. The steel strip 12 is produced by assembling a pair of casting rolls with a nip 15 in-between, assembling a casting pool between the casting rolls above the nip 15 with refractory side dams 35, 35' adjacent to the ends of the nip 15 to confine the casting pool, assembling a steel delivery system comprising a refractory core nozzle 27 and a refractory tundish 26 that delivers molten steel into the casting pool, and then counter rotating the casting rolls to form solidified steel shells on the surfaces of the rolls. The casting rolls cast the steel shells through the nip between the rolls to form thin steel strip 12. Downtime during the casting campaign is reduced by replacement of one or more worn out refractory components of the steel delivery system. While casting continues, a replacement component - a core nozzle, a tundish or a side dam, is preheated to avoid thermal shock when contacted by the molten steel after replacement. The molten steel flow is then interrupted, the casting pool drained, and the worn out component replaced. This is done before the unreplaced components of the steel delivery system cool enough to suffer a thermal shock when they once again come in contact with the molten steel after casting resumes.
Patent NZ-561438-A (NZ)
Title: Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-[1H]-one compounds, pharmaceutical compositions, and use in the manufacture of medicines
Inventor: CALLAHAN JAMES FRANCIS
IPC: A61K31/519
Filed: 2006-03-24
Abstract: Disclosed are the following three compounds: 3-[2-{[3-(diethylamino)propyl]amino}-8-(2,6-difluorophenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-propylbenzamide; 3-[8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide; and 3-{8-(2,6-difluorophenyl)-2-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yI}-4-methyl-N-(1-methyl ethyl)benzamide, and salts thereof. Also more generally disclosed are compound of the pictured formulas, where the substituents and variables are as defined in the specification. Also disclosed is the use of the above compound to treat CSBP/RK/p38 kinase mediated diseases such as asthma, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, and chronic obstructive pulmonary disease (COPD).
Patent NZ-563116-A (NZ)
Title: Wire connector
Inventor: WOOSTER MAURICE WILLIAM
IPC: E04H17/10
Filed: 2007-11-02
Abstract: A wire connector for connecting a fence wire to a post, the wire connector including a length of wire (10) having: (i) a first engaging portion (11) at a first end of the length of wire wherein the first engaging portion is adapted to be connected to either directly or indirectly to a strand of wire of a multi-strand wire fence; (ii) a second engaging portion (14) adjacent a second end of the length of wire wherein the second engaging portion is adapted to releasably engage and retain a portion of the length of wire to form a post engaging loop (18) when the second engaging portion is engaged with the portion of the length of wire, the second engaging portion being formed by bending the second end of the length of wire back on itself to form a substantially U-shaped end portion having a free leg (15) with a wire engaging means (17) adapted to releaseably engage with another leg (16) of the U-shaped end portion so as to retain the portion of length of wire within the bend of the U-shaped end portion when the post engaging loop is formed and in order to maintain the integrity and shape of the formed post engaging loop.
Patent NZ-566831-A (NZ)
Title: Salts of modulators of PPAR and methods of treating metabolic disorders
Inventor: PARENT STEPHAN D
IPC: C07D295/22
Filed: 2006-10-23
Abstract: Disclosed is a salt of a compound of Formula I wherein: A is a saturated hydrocarbon chain, forming a five- membered ring; T is -C(O)OH; G1 is -(CR1R2)n-; n is 0 or 1; X1, X2, and X3 are hydrogen; G2 is a saturated monocyclic heterocycloalkyl linker, G3 is selected from the group consisting of a bond and -(CR3R4)m-; m is 0, 1, or 2; R3 and R4 are hydrogen; and G4 is phenyl; wherein said salt is selected from the group consisting of sodium, potassium, magnesium, calcium, and tosylate exemplified by 4-[cis-2,6-dimethyl-4-(4- trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid for treating obesity, diabetes, hyperinsulinemia, metabolic syndrome X, dyslipidemia, or hypercholesterolemia; treating cardiovascular disease; treating inflammatory disease; or autoimmune disease rheumatoid arthritis, asthma, osteoarthritis, oxidative stress.
Patent NZ-572893-A (NZ)
Title: Myxoma virus mutants for cancer treatment
Inventor: BARRETT JOHN W
IPC: C12N5/071
Filed: 2007-06-01
Abstract: Disclosed is a Myxoma virus that is deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M136, M-T4 and M-T7. The use of the virus for inhibiting cancer cells, treating cancer of non-human subjects and in medicaments for treating cancer is disclosed.
Patent NZ-579937-A (NZ)
Title: Plastic container handling system and method with protruding bottom projection and supplementary body vacuum panels inverting
Inventor: GOSS KENT
IPC: B65D1/02
Filed: 2004-07-30
Abstract: A system for processing a simplified plastic container that is to be filled with a hot product includes the step of blow-molding parison to form a container body, where the container body has a neck, a base, a side surface relatively free of structural geometry that surrounds an interior of the container body and, prior to being filled with the hot product, a projection extending from the container body. After the container body is filled with a hot product in a production line, the neck of the filled container body is capped with a cap and then, the container body is cooled. During the cooling operation, the hot product is contracted so that the projection extending from the container can be pushed into the container body like a traditional push-up so that the resultant, filled and cooled container body is relatively free of structural geometry. This application is directed to a supplementary vacuum panel on the side wall of the container which inverts to assist in accommodating residual vacuum for larger containers. (62) Divided Out of 545528
Patent NZ-588134-A (NZ)
Title: Novel pharmaceutical for use in a method for treatment of upper respiratory mucosal congestion
Inventor: ATKINSON HARTLEY CAMPBELL
IPC: A61K31/135
Filed: 2005-06-17
Abstract: Disclosed is a pharmaceutical composition including about 2.5mg loratadine, or a corresponding amount in the form of a suitable salt substance thereof, as the only therapeutically active ingredient, for administering to a patient four times a day for treating upper respiratory/mucosal congestion. (62) Divided Out of 575838
Patent NZ-588160-A (NZ)
Title: Downpipe debris excluder device with a removable screen that is mounted to move bodily between two positions
Inventor: BULL ROYSTON DOUGLAS
IPC: E04D13/064
Filed: 2010-09-23
Abstract: Disclosed is a device for separating debris from water flowing into a down pipe from a roof gutter. The device includes a compartment (11) defining a water flow passage (18), an upper opening (19) and lower opening (20). The device further includes a second opening (45) that is located between the upper opening (19) and lower opening (20). There are first (35) and second (24) screens. The first screen (35) includes a first section (36) and second section (39). The second screen (24) is inclined and substantially spans the water flow passage (18). During use, water from a roof gutter is received to the compartment (11) through upper opening (19). The second screen (24) collects the solid debris from the water and allows the water to flow through the water flow passage (18) and exit out to the downpipe from lower opening (20). The debris collected in the second screen (24) gets diverted to the second section (39) of the first screen (35). The first screen (35) is accessible to the user via second opening (45) and is movable. This accessibility and movement of first screen (35) facilitates cleaning of first screen (35) by removal of collected debris.
Patent NZ-589385-A (NZ)
Title: Pyridyl Inhibitors of Hedgehog Signalling
Inventor: GUNZNER JANET
IPC: C07D213/38
Filed: 2005-09-02
Abstract: Disclosed are pyridyl compounds of formula I, salts and solvates thereof, wherein the substituents are as defined in the specification, that inhibit the hedgehog signalling pathway and their use in treating hyperproliferative diseases and angiogenesis mediated diseases. (62) Divided Out of 553802
Patent NZ-591146-A (NZ)
Title: Composition comprising mesenchymal stem cell aggregates wherein the D90 of said aggregates is less than 150 micomills
Inventor: DANILKOVICH ALLA
IPC: A61K35/12
Filed: 2009-08-14
Abstract: Disclosed are purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold limits for intravenous administration of mesenchymal stem cell pharmaceutical compositions comprising residual animal products are also disclosed.
Patent NZ-593759-A (NZ)
Title: Benzothiazole derivatives as raf inhibitors and anticancer agents
Inventor: OKANIWA MASANORI
IPC: A61K31/428
Filed: 2009-12-01
Abstract: Disclosed are benzothiazole-containing compounds of formula (I), salts thereof, and methods for their preparation. Specific examples of compounds of formula (I) include: 2-Chloro-N-[3-({ 7-cyano-2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl} oxy)phenyl]-3-(1-cyano-1-methylethyl)benzamide, N-{ 7-Cyano-6-[4-fluoro-3-({ [4-trifluoromethyl)phenyl]carbamoyl} amino)phenoxy]-1,3-benzothiazol-2-yl} cyclopropanecarboxamide, and N-{ 7-Cyano-6-[3-({ [3-(trifluoromethyl)phenyl]acetyl} amino)phenoxy]-1,3-benzothiazol-2-yl} cyclopropanecarboxamide. The compounds are effective Raf inhibitors and are useful for the treatment of cancer.
Patent NZ-594592-A (NZ)
Title: Paediatric solutions comprising a beta-blocker
Inventor: CORDOLIANI JEAN-FRANCOIS
IPC: A61K9/00
Filed: 2010-04-12
Abstract: 594592 Disclosed herein is an aqueous ethyl alcohol free solution comprising a propranolol or pharmaceutically acceptable salts thereof, a non sugar type sweetener, such as saccharin sodium, and an aromatic preservative agent present in an amount of less 5 than 0.01w/V%; and the use thereof in the treatment of hemangiomas, specifically for administration to children. Additionally disclosed is said solution further comprising: at least one flavouring agent, such as vanilla flavour; and/or at least one viscosity increasing agent, such as hydroxyethylcellulose; and/or a pH regulator or buffer.
Patent NZ-594595-A (NZ)
Title: Fulid machine of the francis turbine type with a sealing portion featuring a groove with a defined cross sectional shape
Inventor: KAWAJIRI HIDEYUKI
IPC: B08B17/00
Filed: 2011-08-15
Abstract: Disclosed is a Francis Turbine type fluid machine. The machine includes a sealing portion which is formed of an annular minute gap formed between a runner band of a runner configuring a rotating portion and a sealing liner which is a stationary portion and arranged in opposition to the runner band. The machine has a groove having a quadrangular cross-sectional shape which is formed circumferentially on a surface of the sealing liner configuring the sealing portion. In a cross section perpendicular to a groove forming direction of the groove, an angle, which is formed between a side of the groove on the most upstream side with respect to the flowing direction of the leakage flow, and a side of the groove which is on an extended line of the surface of the sealing liner, is determined to be between 15 degree and 40 degree .
Patent NZ-594868-A (NZ)
Title: Protein-containing emulsions and adhesives, and manufacture and use thereof
Inventor: PARKER ANTHONY A
IPC: C09J189/00
Filed: 2010-03-08
Abstract: 594868 Disclosed herein are emulsions and adhesives comprising proteins that can be isolated from a variety of sources including renewable plant biomass, and methods of making and using such emulsions and adhesives. In a preferred embodiment the adhesive composition comprises: (a) from about 5 % to about 90 % (w/w) of a reactive prepolymer such as a polyisocyanate-based prepolymer, an epoxy-based prepolymer, or a combination thereof; and (b) from about 10 % to about 99 % (w/w) of an isolated polypeptide composition that disperses the reactive prepolymer in an aqueous medium, or an isolated water-soluble polypeptide composition, wherein the isolated polypeptide composition is derived from corn, wheat, sunflower, cotton, rapeseed, canola, castor, soy, camelina, flax, jatropha, mallow, peanuts, tobacco, whey, or a combination thereof.
Patent NZ-598570-A (NZ)
Title: Surfactant is alkoxylated fatty acids in an agricultural adjuvant compositions, pesticide compositions, and methods for using such compositions
Inventor: PAZHIANUR RAJESH
IPC: A01N25/00
Filed: 2006-11-14
Abstract: Disclosed is an adjuvant composition comprising, (a) one or more (C12-C14)alkyl dimethyl betaine surfactant compounds, and (b) one or more surfactant compounds selected from: alkoxylated fatty acids, which are selected from:(i) saturated or unsaturated mono- or di- fatty acids, alkoxylated with from 2 to 20 moles of a (C2-C4)alkylene oxide; and (ii) ethoxylated tall oil fatty acids. Also disclosed is a pesticide composition comprising the adjuvant composition and an effective amount of a pesticide, which is selected from the group consisting of: (i) glufosinate, glyphosate, water soluble glufosinate salts, water soluble glyphosate salts, and any mixture thereof; (ii) potassium, sodium, isopropyl amine, and ammonium salts of glyphosate; and (iii) glyphosate isopropyl amine salt.
Patent NZ-601615-A (NZ)
Title: Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
Inventor: MCCAULEY SCOTT ALAN
IPC: A61K39/395
Filed: 2011-02-04
Abstract: Disclosed is an isolated antibody to lysyl oxidase-like-2 (LOXL2) or an antigen binding fragment thereof that specifically binds to an epitope within amino acids 325 through 434 of the sequence set forth in SEQ ID NO: 1, wherein the sequence is as disclosed in the specification. Also disclosed is the use of the said antibody to access the level of LOXL2.
Patent NZ-611746-A (NZ)
Title: Artificial lawn
Inventor: VAN BALEN JEROEN ALBERT
IPC: E01C13/08
Filed: 2011-12-08
Abstract: An artificial lawn (20), in particular for an artificial grass sports field is disclosed. The lawn comprises a substrate (25) and integral, elongate artificial fibres (12) extending upwards between and parallel to the substrate (25). The substrate (25) is formed so that protrusions extend upward and between the artificial fibres (12) in order to provide support to the fibres and a dampening effect that would normally be provided by granular materials. The lawn (20) may be provided in interconnecting modular elements that are joined together to form the surface.
Patent NZ-613252-A (NZ)
Title: Peptide epoxyketones for proteasome inhibition
Inventor: SHENK KEVIN D
IPC: A61P35/00
Filed: 2007-06-19
Abstract: Disclosed is a oxirane, thiirane, or aziridine substituted dipeptide of formula (II) where the peptide comprises two amino acids with aromatic side chains such as phenylalanine, tyrosine, tryptophan and histidine and derivate of these amino acids where the substituents are as disclosed in the specification. Also disclosed are pharmaceutical compositions comprising a compound of formula (II) and the use of a compound of formula (II) in the manufacture of a medicament for the treatment of an immune related disease or cancer.
Patent NZ-616262-A (NZ)
Title: A building element for a structural building panel
Inventor: DINCEL BURAK
IPC: E04B2/00
Filed: 2012-04-10
Abstract: Disclosed is an extruded hollow longitudinally elongated building element (12) into which concrete is poured. The building element comprises a pair of longitudinally extending spaced walls (13) which are longitudinally coextensive and longitudinally parallel, a plurality of longitudinally extending spaced transverse webs (16) joining the side walls, a pair of longitudinally extending grooves (21) formed in respective side walls, a pair of longitudinally extending end flanges (22) extending from respective side walls, a pair of longitudinal surfaces (20) that diverge from the respective side walls toward the grooves, and a sealing projection (see 26, figure 6) extending from each flange and extending longitudinally. The end flanges each include a first portion (23) extending from a respective one of the side walls, and a second portion (24) extending transversely from the first portion. The end flanges and grooves are positioned such that the second portion of each end flange of one building element will engage, with a snap fit, the grooves of a like building element to sealingly interconnect like building elements. During interconnection of the building elements the end flanges are resiliently deformed by engagement with the longitudinal diverging surfaces of the like element.
Patent NZ-630199-A (NZ)
Title: Process and intermediates for preparing integrase inhibitors
Inventor: PCION DOMINIKA
IPC: C07D215/56
Filed: 2013-08-01
Abstract: Disclosed are intermediates compounds 5 and 8 that can be used to prepare 4-oxoquinolone compounds of formula 13 having useful integrase inhibiting properties. The chemical names of the synthesised compounds and intermediates are: 1-chloro-3-(2,4-dimethoxybenzyl)-2-fluorobenzene (5) 1-[5-(3-chloro-2-fluoro-benzyl)-2,4-dimethoxyphenyl]-ethanone (8) ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate (9)
Patent NZ-703788-A (NZ)
Title: Dry powder for inhalation formulation comprising salmeterol xinafoate, fluticasone propionate and tiotropium bromide, and method for preparing same
Inventor: KIM KYEONG SOO
IPC: A61P11/06
Filed: 2013-06-03
Abstract: Provided is a dry powder for inhalation formulation comprising salmeterol xinafoate, fluticasone propionate and tiotropium bromide, as pharmaceutically active ingredients, and a carrier, and an inhalation formulation comprising same. The inventive dry powder inhalation formulation having good content uniformity and showing small changes in the aerodynamic size distribution in accordance with the flow rate changes can effectively deliver said pharmaceutically active ingredients to a target site upon administration, and thus can be useful in the prevention or treatment of respiratory diseases, particularly asthma and COPD.
Patent NZ-710201-A (NZ)
Title: Cd37-binding molecules and immunoconjugates thereof
Inventor: DECKERT JUTTA
IPC: C12N5/0781
Filed: 2012-03-30
Abstract: Disclosed is an antibody or antigen binding fragment thereof that specifically binds to CD37, and in vitro or ex vivo methods for depleting a B-cell comprising contacting a population of cells comprising a B-cell with said antibody or antigen binding fragment.
Patent NZ-715509-A (NZ)
Title: Switch assembly with rotatable operational part
Inventor: SHAN FUHUA
IPC: H01H9/02
Filed: 2015-12-22
Abstract: Disclosed is a switch assembly, a carrier for a driver in the switch assembly, an operational part, a cover unit, and a method for rotating an operational part of the switch assembly, in which an installation angle or orientation of the switch assembly can be easily changed. In one aspect, the switch assembly is provided by a functional part and an operational part with an interface for interfacing between the operational part and the functional part. In another aspect, the operational part is designed to be operable to change its installing angle with respect to the cover unit or plate in a plane parallel to the cover unit or plate.
Patent NZ-718101-A (NZ)
Title: Rectal drain appliance
Inventor: GREGORY CHRISTOPHER
IPC: A61F5/44
Filed: 2009-05-01
Abstract: A rectal drain catheter 10 is provided with an inflatable retaining cuff 20 at a distal end 16 of the main tubular drainage element 12 and inflation lumen 22, 24 for the cuff that is not collapsible and a flushing lumen 50 that is collapsible with the main drain lumen 12 of the catheter, but has a larger cross section than the inflating lumen when not collapsed.
Patent NZ-729207-A (NZ)
Title: Neutralization of inhibitory pathways in lymphocytes
Inventor: ANDRE PASCALE
IPC: C07K16/28
Filed: 2015-09-15
Abstract: The present invention relates to use of a non-depleting anti-NKG2A antibody Z720 in the manufacture of a medicament for treating an HLA-E expressing cancer, wherein the medicament is to be administered with an anti-PD-L1 antibody, and wherein the anti-NKG2A antibody comprises HCDR1 of SYWMN, HCDR2 of RIDPYDSETHY, HCDR3 of GGYDFDVGTLYWFFDV, LCDR1 of RASENIYSYLA, LCDR2 of NAKTLAE, and LCDR3 of QHHYGTPRT.
Patent NZ-756554-A (NZ)
Title: Pet feeders
Inventor: HILL NICHOLAS PATRICK ROLAND
IPC: A01K5/02
Filed: 2014-08-28
Abstract: This invention generally relates to animal feeders, an animal feeder monitor and a method of training an animal to use a feeder. An animal feeder may have a housing comprising an aperture for a food bowl and having a door for covering the aperture, the feeder comprising a door mechanism to control movement of the door over the aperture, wherein the feeder comprises a load cell for weighing an amount of food placed in the feeder and an interface for providing to a user data based on a result of said weighing. The interface is a communications interface for sending the data to a remote site, and the data provided to the user comprises at least one of an amount of food provided to an animal by the feeder and an amount of food removed from the feeder by an animal such that the user can monitor the amount of food delivered to and consumed by the pet.