baber/WOPTO huggingface dataset:
Patent DE-69231952-T2 (DE)
Inventor: TONER L
IPC: A61K47/48
Filed: 1992-05-07
Granted: 2002-04-04
Abstract: A targeting radioactive immunoreagent comprises a metal radionuclide ion, a complexing agent, and an immunoreactive group covalently bonded to said complexing agent, the complexing agent having the structure (AI), wherein R represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R<1> represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R<2> represents hydroxy, carboxy, hydroxyalkyl, thioalkyl, formyl, carbonyliminodiacetic acid, methyleneiminodiacetic acid, methylenethioethyleneiminodiacetic acid, carboxyalkylthioalkyl, hydrazinylidenediacetic acid, or a salt of such acids, or two R<2> groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one, preferably two alkylene groups forming part of the ring structure; R<3> represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R<4> represents hydrogen or a protein reactive group; n is 0 to 4; o is 0 or 1; m is 0 or 1; provided that at least one of n and m is 0 and at least one of R, R<1>, R<3> and R<4> is a protein reactive group. In another aspect, this invention provides novel terpyridines, quaterpyridines, quinqepyridines, sexipyridines and phenanthrolines having the structure (AI). Preferred terpyridines have the structure (AI) above wherein n=1, o=1, m=0, and R is a protein reactive group or a phenyl substituted with a protein reactive group. Optionally, the phenyl may also contain one or more substituents selected from alkyl and alkoxy. Preferred phenanthrolines have the structure (AI) above wherein n=0, o=1, m=1 and at least one R<4> is a protein reactive group. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.
Patent DE-69301176-T2 (DE)
Inventor: POLLARI ALPO ANTERO
IPC: B27N3/06
Filed: 1993-04-03
Granted: 1996-05-15
Abstract: The invention concerns a paper-based, soft or semi-hard sheet material, which contains a core (15) layer of compressed shredded paper with surface (16,17) layers. The material is suited for use as inner end shields (fig.2) for paper reels, for example. <IMAGE>
Patent DE-69302760-T2 (DE)
Inventor: MORIZOT RICHARD ALBERT PIERRE
IPC: B29C70/44
Filed: 1993-06-30
Granted: 1996-11-28
Abstract: In order to produce multilayer structures made of composite materials, by draping pre-cut elementary layers over a forming die (12), an installation is proposed comprising, in addition to the forming die (12), a gripping tool (16) capable of being mounted, for example, on the articulated arm of a robot. The forming die (12) comprises a flexible membrane (28), equipped with suction suckers (58) which grip the pre-cut elementary layers. A vacuum circuit (48) enables the membrane (28) to be pressed up against a counter-shape (26) placed behind the latter, in order to shape the elementary layer picked up. When the tool (16) is brought onto the die (12), a pressure source (52) acts on the membrane (28) in order to compact the elementary layer on the die. A suction system (76, 82) keeps this layer on the die, after releasing the suction via the suckers (58). <IMAGE>
Patent DE-69304194-T2 (DE)
Inventor: KONDRATENKO VLADIMIR STEPANOVI
IPC: C03B33/09
Filed: 1993-04-02
Granted: 1997-01-23
Abstract: A method of cutting non-metallic materials, specifically glass, resides in the heating of the material by an incident beam of radiation being effected to a temperature short of its softening point, with the rate of relative displacement of the beam and of the material, and the region of the heated zone which is locally cooled being selected to form a blind crack in the material. The method provides for increasing substantially the cutting speed and accuracy, and also for controlling the depth, shape and angle of the cut face formed by the crack. The method can be employed in the automotive industry for making glass windows and mirrors, in the electronics industry for making precision backings and substrates for LED indicator panels and masks, magnetic and optomagnetic disks, in watch-making for making protective glasses, in the aircraft and space industry for making structural optics components, in construction and architecture for dimensional pattern-cutting of glass, including its integration in the glass manufacturing technology, and also in other fields of production and technologies where precision of non-metallic materials are made.
Patent DE-69315511-T2 (DE)
Inventor: OSGAR MICHAEL L
IPC: B67D3/00
Filed: 1993-09-07
Granted: 1998-04-02
Abstract: A container (10) for storage, transport, and dispensing of liquid chemicals includes a fluid container (12) having a port (18), a dip tube (22) having a fluid passage from an upper end to a lower end of the dip tube, a dip tube coupling (24) at the upper end of the dip tube (22) for insertion into the port, and a rupturable membrane (27) sealed over a top end of the port. The dip tube coupling (24) has a cavity (76) in its upper end and a fluid passage (80) connecting the cavity (76) with the fluid passage of the dip tube (22). The dip tube coupling (24) defines a gas passage (90) extending from an interior of the fluid container to the cavity (76). A rupturable membrane (27) is positioned over a top end of the port to seal the cavity, so that when the rupturable membrane (27) is punctured or removed, gas from the fluid container (12), which has accumulated in the cavity, is permitted to escape. To remove the liquid chemical, the cap (28) is removed to expose the rupturable membrane (27). A probe (46) is next inserted through the membrane (27) to allow gas to escape, and into the cavity (76), whereby the probe (46), upon insertion into the cavity (76), causes the gas passage (90) to be blocked. Liquid is dispensed from the fluid container (12) through a fluid passage within the dip tube (22) and through a flow passage (144) within the probe (46). <IMAGE>
Patent DE-69319949-T2 (DE)
Inventor: AGUT SANZ JUAN
IPC: H01H50/88
Filed: 1993-02-27
Granted: 1999-02-11
Abstract: It is applicable to electric contactors and has bellows whose air intake is controlled by a limited duct with a variable section and length. The limited duct is established by a radial hole (1) made in flange (2) immobilized with regard to the adjustment knob (3), that communicates hole (8) of the base or core (4) of the bellows (5), with the air intake hole (9) made in the core (10) of the adjustment knob (3), the flange (2) preferably having a transversal or peripheral groove (7) as of the radial hole (1.) When the adjustment knob (3) is placed in a certain position, the timing is governed in terms of the limited duct implied by the length of the transversal groove (7), which may have a section gradually increasing towards the radial hole (1.) The air duct can also be gauged with the thread of a screw (12) whose head (13) forms a variable anular duct with the wall of an axial truncated- cone hole (11) provided in the core (10.) <IMAGE>
Patent DE-69327949-T2 (DE)
Inventor: CHERPECK E
IPC: C10L1/222
Filed: 1993-12-17
Granted: 2000-06-29
Abstract: A fuel additive composition comprising: (a) a poly(oxyalkylene) hydroxyaromatic ester having the formula:   <IMAGE>    or a fuel-soluble salt thereof; where R1 and R2 are each independently hydrogen, hydroxy, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms; R3 and R4 are each independently hydrogen or lower alkyl having 1 to 6 carbon atoms; R5 is hydrogen, alkyl having 1 to 30 carbon atoms, phenyl, aralkyl or alkaryl having 7 to 36 carbon atoms, or an acyl group having the formula:   <IMAGE>    where R6 is alkyl having 1 to 30 carbon atoms, phenyl, or aralkyl or alkaryl having 7 to 36 carbon atoms; R7 and R8 are each independently hydrogen, hydroxy, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms; n is an integer from 5 to 100; and x and y are each independently an integer from 0 to 10; and (b) a poly(oxyalkylene) amine having at least one basic nitrogen atom and a sufficient number of oxyalkylene units to render the poly(oxyalkylene) amine soluble in hydrocarbons boiling in the gasoline or diesel range.
Patent DE-69334064-T2 (DE)
Inventor: DE BOER MARK
IPC: C12N15/06
Filed: 1993-07-08
Granted: 2007-05-24
Abstract: The present invention relates to a method of generating antibodies directed against cell surface antigens and it uses recombinant insect cells as immunogens. The insect cells have been transfected with coding regions for a molecule containing a cell surface antigen and these antigens are expressed on the surface of the insect cells. Host animals are immunized with these transfected insect cells to generate antibodies directed against the cell surface antigen. Antibody-producing cells from the host animal are used to generate monoclonal antibody-producing hybridoma cells. Sera and hybridoma supernatants can be tested for the presence of antibodies against the surface antigen, using the transfected cells in a screening assay. Specific antibodies that have been generated by the present method are anti-B7 and anti-CD40 antibodies and they can be used to prevent or treat an antibody-mediated or immune system disease in a patient. The anti-B7 antibodies can be used to cause T cell anergy, treat allograft transplant rejection, treat graft versus host disease, and prevent or treat rheumatoid arthritis. An immunosuppressive agent may be co-administered with the antibody. The anti-CD40 antibodies which bind to the CD40 antigen can be used to prevent the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Patent DE-69402556-T2 (DE)
Inventor: HODGKINSON IAN BANKFIELD DRIVE
IPC: B01J23/76
Filed: 1994-05-27
Granted: 1997-07-17
Abstract: N-Phosphonomethylglycine and its salts are manufactured by hydrolysing N-phosphonomethyl-2-oxazolidinone in an aqueous medium and thereafter oxidising the hydrolysis product in an aqueous alkaline medium using an oxygen-containing gas in the presence of an oxidation catalyst, for example a platinum or palladium catalyst optionally containing a promoter such as bismuth.
Patent DE-69404288-T2 (DE)
Inventor: GRAY RALPH
IPC: C23C22/34
Filed: 1994-02-23
Granted: 1998-01-22
Abstract: Aqueous acid solutions for treating metal surfaces such as aluminum and galvanized steel are disclosed. The solutions are mixtures of organophosphates or phosphonates and chloride or fluoride. The treating solutions can be used in place of chromium treating solutions.
Patent DE-69404412-T2 (DE)
Inventor: SEMERIA DIDIER
IPC: A61K8/36
Filed: 1994-10-11
Granted: 1997-12-04
Abstract: The ceramides according to the invention are compounds corresponding to the formula: <IMAGE> in which: R1 is a C11 to C21 alkyl or alkenyl radical; R2 is a linear or branched C1 to C29 hydroxyalkyl radical or a C7 to C29 hydroxyaralkyl radical, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers, for the aminodiol part <IMAGE>  in the proportions erythro:threo of 85:15 to 20:80. Application to cosmetic and dermopharmaceutical compositions.
Patent DE-69404835-T2 (DE)
Inventor: IMBACH JEAN-LOUIS
IPC: C07H21/00
Filed: 1994-05-11
Granted: 1998-03-12
Abstract: PCT No. PCT/FR94/00563 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed May 11, 1994 PCT Pub. No. WO94/26764 PCT Pub. Date Nov. 24, 1994The trister phosphorothioate oligonucleotides disclosed comprise internucleotide concatenations having a P-S- bond protected by a bioreversible grouping (X) in intracellular media.
Patent DE-69405862-T2 (DE)
Inventor: BURKHOLDER TIMOTHY
IPC: A61P37/08
Filed: 1994-04-22
Granted: 1998-01-15
Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
Patent DE-69423481-T2 (DE)
Inventor: GURUCEAGA ZUBILLAGA MIKEL
IPC: F02K1/12
Filed: 1994-09-12
Granted: 2000-11-09
Abstract: Improvements in orientable axisymmetric nozzles of variable geometry which are intended for gas turbine engines, which nozzles comprise a convergent zone (2) followed by a divergent zone (3), both formed by main petals (4-5) and secondary petals (33-34), and they add to the known functions (simultaneous axisymmetric variation, according to a preestablished law, of the throat area A8 and of the outlet area A9; variation of all the geometry of the outlet area A9 independently of the throat area A8; and, axisymmetric orientation of the flow) a fourth function of varying only a part of the geometry of the outlet area A9 independently of the throat area A8. <IMAGE>
Patent DE-69432795-T2 (DE)
Inventor: TRAVIS JAMES
IPC: C12N9/52
Filed: 1994-09-09
Granted: 2004-04-29
Abstract: Provided herein is a nucleotide sequence encoding an Arg-specific gingipain named gingipain-1 isolated from Porphyromonas gingivallis, having an apparent molecular mass of 50 kDa as estimated by SDS gel electrophoresis and an apparent molecular mass of 44 kDa as estimated by gel filtration chromatography. Gingipain-1 has amidolytic and proteolytic activity for cleavage after arginine residues and has no amidolytic and/or proteolytic activity for cleavage after lysine residues. Its activity is inhibited cysteine protease group-specific inhibitors and chelating agents. It is stabilized by Calcium and stimulated by glycine-containing peptides and glycine analogues.
Patent DE-69433268-T2 (DE)
Inventor: PULNEV SERGEI APPOLONOVICH
IPC: A61F2/82
Filed: 1994-12-23
Granted: 2004-09-16
Abstract: A stent in the form of a three-dimensional body consists of interwoven threads (1) arranged as multiple turns in a helix. The threads (1) are arranged in at least two groups (2 and 3) of turns in the helix, having opposite directions of rotation. The ends of the stent (5) consist of zones for the transition of the turns of one helix into the turns of the other helix, which are formed from a single length of thread.
Patent DE-69501386-T2 (DE)
Inventor: JOUET ARMELLE
IPC: C23C2/28
Filed: 1995-10-19
Granted: 1998-07-23
Abstract: Interstitial free steel sheet is coated with Al, Zn or Al Zn alloy by dipping the heated steel into a relatively cool bath of molten Al, Zn or alloy and subjecting the dipped steel to a heat treatment of less than 5 mins., pref. around 2 mins., duration where it is first heated quickly to a temp. above 300 degrees C but below the temp. at which the coating would alloy with the steel and then quickly cooling to ambient temp. The heat treatment temp. is 550-625 degrees C for Al or Al alloy, 320-390 degrees C for Zn or Zn alloy and 390-550 degrees C for an alloy of Al and Zn. Prior to dipping the steel is cleaned and recrystallised by heating in a non-oxidising atmosphere. The Al based coating provides a base for subsequent enamelling and the Zn based coating for a paint coating which needs to be baked at over 100 degrees C.
Patent DE-69522659-T2 (DE)
Inventor: WALL ROBERT
IPC: B65D1/26
Filed: 1995-10-17
Granted: 2004-08-26
Abstract: Embodiments of the present invention feature a multilchambered cuvette having a first movement pattern and a second movement pattern, the first movement pattern comprises a stationary position and a rotation about a circular path. The second movement pattern comprises a rocking motion. The cuvette uses the first movement of fluid between chambers and a second movement pattern to effect mixing and incubation. The cuvette features a unitary housing having an opening over the first and second compartments to allow viewing and access.
Patent DE-69531270-T2 (DE)
Inventor: GEPHARDT DOUGLAS
IPC: G06F9/46
Filed: 1995-05-17
Granted: 2004-04-22
Abstract: A symmetrical multiprocessing system is provided that includes centralized interrupt control unit. The interrupt control unit is coupled to a plurality of processing units and to a plurality of interrupt sources. The interrupt control unit advantageously allows for the expansion of each interrupt pin by setting the interrupt control unit in a cascade mode. Furthermore, the central control unit is responsive to specialized interrupt cycles which allows I/O devices and/or bus bridge devices to initiate of an interrupt without requiring a dedicated interrupt line. The central interrupt control unit further allows each interrupt to be prioritized independently of its associated vector ID, and prevents the occurrence of spurious interrupts by providing a programmable latency timer which causes the central interrupt control unit to delay its response to End Of Interrupt (EOI) instructions. An auto-chaining technique is further implemented by the central interrupt control unit to sequentially provide broadcast interrupts to various processing units based on their current task priority values. Finally, the central interrupt control unit further handles system management interrupts (SMIs) from sources such as power management units and ensures proper system operation even if the requested system management function affects operations being carried by other processing units. <IMAGE>
Patent DE-69534776-T2 (DE)
Inventor: ELGOYHEN ANA BELEN
IPC: G01N33/53
Filed: 1995-07-18
Granted: 2006-10-12
Abstract: The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
Patent DE-69601640-T2 (DE)
Inventor: VAN GINKEL CORNELIS
IPC: C12S99/00
Filed: 1996-06-13
Granted: 1999-09-02
Abstract: PCT No. PCT/EP96/02584 Sec. 371 Date Dec. 22, 1997 Sec. 102(e) Date Dec. 22, 1997 PCT Filed Jun. 13, 1996 PCT Pub. No. WO97/02217 PCT Pub. Date Jan. 23, 1997The microbiological degradation of alkylene amine acetates under alkaline conditions using microorganisms present in activated sludge is achieved by contacting the alkylene amine acetate-containing waste, at a pH of about 9 or less, with activated sludge containing a wide range of microorganisms, in the absence of carrier materials.
Patent DE-69604153-T2 (DE)
Inventor: SALERI GIUSEPPE
IPC: F23D14/00
Filed: 1996-06-20
Granted: 2000-05-25
Abstract: A burner (1) for gas cookers, comprising a central flame crown (17; 17a), two concentric circumferential crowns (18, 19), a substantially horizontal Venturi effect chamber (27) and holes or slits (28) for supplying a mixture of air and gas from the Venturi chamber (27) to the central crown (17), located in proximity to the zone of cessation of the Venturi effect and/or downstream of the said zone, with respect to the flow of the gas-mixture. <IMAGE>
Patent DE-69614744-T2 (DE)
Inventor: BORTOLUZZI GUIDO
IPC: A47C17/17
Filed: 1996-03-28
Granted: 2002-07-04
Abstract: Divan-bed comprising a fixed frame (1) resting on the floor, a backrest (8) and a seat (14), in which at least two longitudinal sides (1a) of the said frame (1) are formed by rails (2) guiding a carriage (3) movable in translation along a horizontal plane, said carriage having pivotably hinged on it the backrest (8) and a shaped lever (10), the opposite ends of which are rotationally connected, respectively, to the said backrest (8) via a rod (12) and to the seat (14), there also being provided locking means (19, 18, 15, 16) cooperating with said adjusting means for fixing the relative position of the backrest (8) and seat (14) and their inclination with respect to the horizontal plane of the floor. <IMAGE>
Patent DE-69618230-T2 (DE)
Inventor: DUBIEF CLAUDE
IPC: C11D3/20
Filed: 1996-09-16
Granted: 2002-06-13
Abstract: A cosmetic or dermatological composition for treating keratinous material, particularly human hair, including a cosmetically or dermatologically acceptable medium containing at least one silicone-grafted polymer with a polysiloxane portion and a portion consisting of a non-silicone organic chain, wherein one of the two portions constitutes the main polymeric chain while the other is grafted onto said main chain, and at least one copolymer with a polysiloxane-polyoxyalkylene linear block as the repetitive units, as well as the uses thereof, are disclosed. Such compositions are particularly suitable for use as rinsable or non-rinsable products for washing and conditioning hair, hair setting or hair styling.
Patent DE-69622770-T2 (DE)
Inventor: MIYAZAKI TAKESHI
IPC: G02B5/20
Filed: 1996-01-24
Granted: 2002-12-05
Abstract: Disclosed herein is a color filter comprising a transparent base on which a plurality of coloring members different in spectral characteristics from each other, and light-screening members are selectively arranged, wherein the light-screening member are arranged on a resin layer provided on the base, and the coloring members are arranged on or in the resin layer. <IMAGE>
Patent DE-69626348-T2 (DE)
Inventor: ARTUS JEAN-PIERRE
IPC: A63C5/075
Filed: 1996-08-01
Granted: 2003-09-18
Abstract: The shock absorber (14) is fixed to the upper surface of the ski with its longest dimension longitudinal. It has a layer of visco-elastic material (15) which is covered by a plate made of material with a high modulus of elasticity. The plate is an ellipse and its central part has two holes (17) which define a straight longitudinal tongue (18). The tongue is not fixed to the board and is flexible elastically so that it acts like a leaf spring. Its ends are joined to the plate but it does not have a layer of visco-elastic material.
Patent DE-69628764-T2 (DE)
Inventor: INDECK S
IPC: G06F21/00
Filed: 1996-04-01
Granted: 2004-04-08
Abstract: Data recorded on a magnetic medium may be securely identified and manipulated for use in credit balance applications by determining a magnetic fingerprint benchmark on the medium as well as a distance between this benchmark and any pre-selected magnetic feature such as a magnetic transition of a data bit of the data set. Verification of the data may be achieved by measuring this distance and comparing it with the distance recorded at the time that the data was originally placed on the medium. As there is a detectable difference in accuracy between reading this distance as contrasted with illegitimate attempts to write false data at a pre-selected distance from the benchmark, attempts at forgery are detectable.