baber/WOPTO huggingface dataset:
Patent DE-69725118-D1 (DE)
Title: Reagentien für tests für mycophenolsäure
Inventor: STAPLES A
IPC: G01N33/53
Filed: 1997-07-17
Granted: 2003-10-30
Abstract: One aspect of the present invention relates to assays for the detection of mycophenolic acid. The method comprises including in an assay medium suspected of containing mycophenolic acid a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. Another aspect of the present invention is an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in combination in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
Patent DE-69726829-D1 (DE)
Inventor: BORGHI ENZO
IPC: A61F2/856
Filed: 1997-05-29
Granted: 2004-01-29
Abstract: PCT No. PCT/IB97/00620 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed May 29, 1997 PCT Pub. No. WO97/45073 PCT Pub. Date Dec. 4, 1997A bifurcated endovascular stent is formed from a pair of individual tubular component stents that can be placed independently in sequence in the branched region of a body vessel to form the bifurcated stent in situ. The first placed component stent includes a side opening and may be placed to extend both proximally and distally of the bifurcated junction with the side opening facing the entry to the branch vessel. The first component stent then is expanded within the vessel. The second component stent then can be advanced through the first component stent, through the side opening and into the branch vessel where it can be expanded. The portions of the first and second component stents that surround the region of the vessel juncture are constructed to provide enhanced lateral support for the walls of the vessel in the region of the junction. A delivery catheter is provided and includes a guidewire duct adapted to facilitate entry of a guidewire into the branch vessel while the first component stent is being deployed in the other lumen of the vessel.
Patent DE-69730926-D1 (DE)
Inventor: GELFAND DAVID HARROW
IPC: C12Q1/6869
Filed: 1997-07-31
Granted: 2004-11-04
Abstract: The invention provides thermostable DNA polymerase enzymes that comprises the amino acid sequence SerGlnIleXaaLeuArgXaa (SEQ ID NO: 1), wherein "Xaa" at position 4 of this sequence is any amino acid residue but not a glutamic acid residue (Glu), preferably a glycine residue and "Xaa" at position 7 of this sequence is a valine residue (Val) or an isoleucine residue (Ile). The thermostable DNA polymerases of the invention have enhanced efficiency for incorporating unconventional nucleotides, such as ribonucleotides, into DNA products and are advantageous in many in vitro synthesis applications. Such enzymes are particularly useful for use in nucleic acid sequencing protocols and provide novel means for DNA sequence analysis with cost and efficiency advantages. Also claimed are nucleic acids encoding said polymerases, vectors and hoste cells comprising such a nucleic acid, as well as compositions for use in a DNA sequencing reaction, kits and methods for sequencing including such polymerases.
Patent DE-69815872-D1 (DE)
Inventor: CAMPBELL C
IPC: A61K33/243
Filed: 1998-04-08
Granted: 2003-07-31
Abstract: Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. Methods are also provided for preventing or reducing such symptoms in patients undergoing treatment with loop diuretics, aminoglycoside antibiotics, iron chelating agents, quinine, and quinidine, or those who have been exposed to toxic levels of noise or radiation. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent, loop diuretic agent, etc., or exposure to noise or radiation. Combinations of these time periods can also be employed.
Patent DE-69816374-D1 (DE)
Inventor: KJELLERUP KNUD
IPC: A23K20/189
Filed: 1998-05-05
Granted: 2003-08-21
Abstract: The invention relates to a device for providing a corona effect. The device is primarily intended for signs on the facades of buildings, but the device may also be used for other applications where there is desired a corona effect for signs or other visual display devices that cannot be too deep. The device comprises a first translucent element (1) and in a preferred embodiment also a second (2) and a third (3) translucent element. Light is input into the first translucent element (1) by means of optical fibres (15) that have a tip (14) which is fitted in the first translucent element (1). The light (19) is directed forwards and sideways, is reflected and is output backwards through the second (2) translucent element. <IMAGE>
Patent DE-69818671-D1 (DE)
Inventor: PARRINELLO FIORENZO
IPC: B65D41/34
Filed: 1998-07-21
Granted: 2003-11-06
Abstract: A plastic screw cap comprising a cylindrical cup provided with an internal thread and with a pilferproof ring which is connected to the rim of the cup by means of a plurality of bridges which form a circular fracture line, the ring having a plurality of internal flaps which are inclined towards the bottom of the cup; the pilferproof ring comprising a cylindrical wall, whose thickness is such that it is substantially flexible in a radial expansion direction, a rim which is connected to the rim of the cup by the bridges, and an opposite rim which is connected to an internal annular bead whose inside diameter is smaller than the inside diameter of the wall and whose thickness is significantly greater than the thickness of the wall, a plurality of flaps protruding from the region connecting the flexible wall and the internal annular bead and having such a thickness as to acquire substantial rigidity with respect to radial stresses.
Patent DE-69819204-D1 (DE)
Inventor: STORSTROEM HELGE
IPC: B22F3/02
Filed: 1998-12-01
Granted: 2003-11-27
Abstract: This invention concerns a lubricant for warm compaction of iron-based metallurgical powder compositions. 50 to 100% by weight of the lubricant is a polyester, aromatic or partly aromatic, which has a number-average molecular weight Mn of 5,000-50,000. This invention further concerns a metal powder composition containing the lubricant, a method for making sintered products by using the lubricant, and use of the same in warm compaction of metallurgical powders.
Patent DE-69824738-D1 (DE)
Inventor: FRAZER IVO
IPC: E21B25/00
Filed: 1998-08-13
Granted: 2004-07-29
Abstract: A method of acquiring a core sample of seabed material into a core sampling tube having an upper end, a lower open end and a substantially cylindrical chamber extending therebetween, comprising the steps of urging the core sampling tube into the seabed and simultaneously withdrawing fluid from the upper end of the core sampling tube at a rate sufficient to cause the seabed material to be drawn into the core tube at substantially the same rate as the core tube penetrates the seabed.
Patent DE-69825441-D1 (DE)
Inventor: BUTLER MANLEY C JR
IPC: B64D17/34
Filed: 1998-04-21
Granted: 2004-09-09
Abstract: A round conventional parachute is shown with a small auxiliary canopy for controlling the inflation characteristics of the main canopy, especially large generally axisymmetrical canopies for heavy payloads. The main canopy has a central vent at the apex, and suspension lines descend from the lower edge or skirt of the canopy to risers or harness. The small auxiliary canopy is slidably attached to the suspension lines between the main canopy and the harness. The auxiliary canopy includes a generally hemispherical central inner section made of a low air permeable material and a generally annular flat outer section made of a high air permeable material, preferably one offering little or no resistance to air flow therethrough. The outer section is provided with spaced fittings around the periphery to slidably receive individual suspension lines therethrough. When packed, the auxiliary canopy is located near the mouth of the main canopy to control the shape of the mouth of the main canopy during opening but slides down the suspension lines as the main canopy fully inflates thereby controlling the opening sequence. By controlling the inflation characteristics of the parachute with the auxiliary canopy, the opening forces and/or the time to full open can be reduced, or increased, for a given speed.
Patent DE-69830335-D1 (DE)
Inventor: DENNEY LYLE
IPC: A61P7/00
Filed: 1998-10-26
Granted: 2005-06-30
Abstract: The compound, ((3(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid morpholino-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
Patent DE-69834223-D1 (DE)
Inventor: CALBET BENACH JOSE
IPC: A61N1/40
Filed: 1998-07-15
Granted: 2006-05-24
Abstract: With these devices a relative H F (high frequency) electric current applicable to the human body is generated by means of an active electrode and a neutral or return electrode, whose electrodes are connected to the transformer of the output stage of the corresponding circuit. The invention is characterised by the coil of the output transformer having on the secondary winding, besides connections for the end terminals for connecting the neutral or return electrode and an active metallic electrode with electrically insulating cover, an intermediate terminal for connecting an active metallic electrode without insulating cover, whose terminal is furnished with an adequate very reduced impedance with an average which adapts only and exclusively to the different sizes of said metallic electrodes without metallic cover which are used. <IMAGE>
Patent DE-69839905-D1 (DE)
Inventor: BREMEL ROBERT D
IPC: C12N15/85
Filed: 1998-03-18
Granted: 2008-10-02
Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
Patent DE-69840342-D1 (DE)
Inventor: BUCALA RICHARD J
IPC: C12Q1/48
Filed: 1998-10-30
Granted: 2009-01-22
Abstract: There is disclosed a cancer malignancy diagnostic assay comprising obtaining a sample of a body fluid or tissue, performing a sequence identity assay to look for the presence of iPFK-2 specific sequences; an anticancer pharmaceutical composition comprising a specific antisense oligonucleotide to the inventive isolated iPFK-2 sequence and a pharmaceutically acceptable oligonucleotide carrier; and a method for finding therapeutically active anti-cancer compounds comprising screening compounds for activity to inhibit iPFK-2, preferably kinase activity.
Patent DE-69842213-D1 (DE)
Inventor: MABBOTT NEIL RICHARD
IPC: H01B11/10
Filed: 1998-07-10
Granted: 2011-05-19
Abstract: A co-axial cable has a conducting core (10) and surrounding layer or layers of insulation (12). A layer of material (11) is provided between the core (10) and the insulating layer (11) which prevents distortion at high temperature due to thermal expansion. The layer (11) prevents distortion either by melting to form a lubricating layer, or by acting as a physical barrier to distortion. The layer may be made of polyethylene, polypropylene or polybutene or may be glass fibre tape with mica platelets. A screening layer 14, preferably copper braid, is arranged around the insulation.
Patent DE-69902509-D1 (DE)
Inventor: EVANS SCOTT M
IPC: A61F7/12
Filed: 1999-04-06
Granted: 2002-09-19
Abstract: A system for controlling patient temperature uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system. <IMAGE>
Patent DE-69904780-D1 (DE)
Inventor: KEMPEN HENRICUS GERARDUS MARIA
IPC: B41F15/42
Filed: 1999-05-04
Granted: 2003-02-13
Abstract: A magnet bar for exerting an attracting force on a doctor (6), which is arranged above the magnet bar, of a screen-printing or coating device comprises an elongate top plate (2) and an elongate magnet carrier (7) which extends below and substantially parallel to the top plate and on which permanent magnets (8) are arranged next to one another in the longitudinal direction. The distance between the magnet carrier (7) and the top plate (2) can be adjusted by means of a displaceable adjustment member (12), which is arranged below the magnet carrier, in order to adjust the magnitude of the attracting force. The magnet carrier (7) is supported freely on the adjustment member (12) and the weight of the magnet carrier (7) with magnets (8) or the sum of the weight of the magnet carrier (7) with magnets (8) and the force of at least one spring (22) acting upon the magnet carrier in downward direction is greater than the maximum attracting force which can be exerted by the magnets (8) on a doctor (6) which is arranged above the magnet bar. <IMAGE>
Patent DE-69905344-D1 (DE)
Inventor: MAGUIRE B
IPC: B02C18/00
Filed: 1999-02-26
Granted: 2003-03-20
Abstract: A method and apparatus for granulating previously molded solid thermoplastic material for recycling by introducing the previously molded thermoplastic material into a cylindrical granulating zone in a direction parallel with the axis of the cylinder, providing a stationary knife at a cylindrical boundary of the granulating zone, moving a second knife along the cylindrical boundary of the granulating zone to pass in proximity to the stationary knife and thereby trap portions of the previously molded thermoplastic material therebetween to cut the previously molded thermoplastic material into granules, providing an apertured surface as a portion of the cylindrical boundary and sweeping portions of the previously molded thermoplastic material along the apertured surface with the moving knife to cause cut portions of the previously molded thermoplastic material having granule size less than that of the apertures to pass therethrough for recycling by subsequent molding or other processing.
Patent DE-69908564-D1 (DE)
Inventor: YAMAMOTO TETSU
IPC: H01B13/00
Filed: 1999-02-24
Granted: 2003-07-10
Abstract: A method is provided for the production of a membrane of gel composite electrolyte having a uniform membrane thickness. The method has the steps of: mixing a lithium salt, an electrolyte solvent having a boiling point at one atmospheric pressure of not less than 240  DEG C and a diluting solvent having a boiling point at one atmospheric pressure of from 40 DEG  to 210  DEG C to obtain an electrolyte solution; mixing the electrolyte solution with a gelling agent to obtain a gel composite electrolyte; shaping the gel composite electrolyte into a membrane configuration; and removing the diluting solvent from the gel composite electrolyte. The method is characterized by the use of a diluting solvent. The diluting solvent facilitates the shaping step, thereby producing an electrolyte membrane having a uniform thickness. The gelling agent may be fumed silica.
Patent DE-69909502-D1 (DE)
Inventor: JABER ISAM
IPC: C08F210/16
Filed: 1999-08-27
Granted: 2003-08-14
Abstract: A dual reactor process for the solution and (co)polymerization of ethylene uses two different types of catalysts in the two reactors. A catalyst having a phosphinimine ligand is used in the first reactor. A Ziegler Natta catalyst is used in the second reactor. The process of this invention is comparatively easy to control and may be used to produce polyethylene products having a broad molecular weight distribution. Linear low density produced according to this invention is well suited for the manufacture of molded goods and plastic films.
Patent DE-69916086-D1 (DE)
Inventor: QUERCIOLI ENRICO
IPC: B65D75/56
Filed: 1999-12-30
Granted: 2004-05-06
Abstract: In a packet having an engagement portion for hanging on a display unit, the engagement portion has a slot (7a, 7b) for engagement by an elongate member which projects from the display unit. The slot (7a, 7b) has a transverse opening (10) for permitting the forced passage of the elongate member as a result of the application of a force to the packet (1) in a direction substantially transverse the elongate member. <IMAGE>
Patent DE-69919030-D1 (DE)
Inventor: KEOGH S
IPC: B42D15/10
Filed: 1999-12-07
Granted: 2004-09-02
Abstract: An apparatus and method of forming filament circuit patterns with planar and non-planar portions and interconnection cards, smart cards or optical fiber circuit cards formed therefrom are provided. A filament circuit path is scribed by moving a filament guide and a substrate relative to one another, and dispensing a filament on, or in the vicinity of, a surface of the substrate. The filament or the substrate or both have adhesive surface(s). The adhesive surface is capable of being adhesively actuated by application of energy. Energy is applied simultaneous with, or subsequent to, scribing. A portion of the filament circuit pattern is planar and another portion is non-planar. The non-planar portion traverses but does not contact or adhere to a pre-selected area of the substrate. The pre-selected area corresponds with a pad, a contact pattern, a hole, a slot, a raised feature, a part of the previously scribed planar portion of the pattern, and a filament termination point. Alternately, the non-planar portion may be embedded below the surface of the substrate. Another planar portion of the filament circuit traverses the non-planar portion but does not contact or adhere to a pre-selected part of the previously scribed non-planar portion. According to the above method wire-scribed circuit boards are formed including interconnection cards, smart cards or optical fiber circuit cards.
Patent DE-69920940-D1 (DE)
Inventor: VADDI R
IPC: C12Q1/37
Filed: 1999-10-19
Granted: 2004-11-11
Abstract: The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.
Patent DE-69922513-D1 (DE)
Inventor: MAUCH M
IPC: A61M25/00
Filed: 1999-08-24
Granted: 2005-01-13
Abstract: There is described a bifurcated catheter assembly provided for treating bifurcated vessels. The bifurcated catheter assembly comprises an elongate main catheter shaft having a stiffer proximal portion, a more flexible distal portion, and a pair of branch catheters attached to the distal portion. An expandable member is located on each of the branch catheters. The balloons are held together to provide a low profile as the device is advanced over the tracking guide wire. Upon reaching the bifurcated vessel, the balloons separated and are advanced over separate guide wires into separate branches of the bifurcated vessel. The bifurcated catheter assembly can be used to dilate a stenosis or deliver and implant a Y-shaped stent in the bifurcation.
Patent DE-69923432-D1 (DE)
Inventor: BROWN J
IPC: A61B17/00
Filed: 1999-09-24
Granted: 2005-03-03
Abstract: The present invention relates to a cylindrical expandable stent comprising a plurality of undulating band-like elements. The band-like elements having alternating peaks and troughs, wherein the band-like elements are aligned on a common longitudinal axis to define a generally tubular stent body. The peaks and troughs take a generally longitudinal direction along the cylinder. The stent further comprises a plurality of interconnecting elements, each interconnecting element having a first end and a second end, the first and second ends extending from adjacent band-like elements. The first and second ends are displaced circumferentially along the stent, wherein the plurality of interconnecting elements comprise similarly oriented first and second interconnecting elements being disposed at different oblique angles.
Patent DE-69938717-D1 (DE)
Inventor: TRAGO BRADLEY A
IPC: H02K29/00
Filed: 1999-03-11
Granted: 2008-06-26
Abstract: An electric machine, such as a motor or a generator, comprises a stator having a plurality of stator poles defining a plurality of slots, a rotor positioned within the stator, and at least a two sets of stator windings wound on the stator poles and occupying said stator slots such that the boundary windings of each set of stator windings occupies a common slot. These boundary windings of each set of stator windings are non-overlapping and include insulation positioned between them. The sets of stator windings are wound on the stator poles in a single pitch winding configuration significantly reducing the number of wire crossings resulting. In particular, the endturns defined by the individual phase coils are non-intersecting. Such a machine provides continued operation under various fault conditions.
Patent DE-69939271-D1 (DE)
Inventor: SLAWINSKI MICHAEL D
IPC: A63B21/078
Filed: 1999-11-23
Granted: 2008-09-18
Abstract: A dumbbell clamp for a barbell and dumbbell safety spotting apparatus [ 30 ] utilizes two spaced-apart plates [ 162 ] each having a notch [ 166 ] for retaining the grip [ 28 ] of a dumbbell [ 26 ]. A spring-biased lock bar [ 170 ] locks the dumbbell grip in the notches during normal use. A clamp bore [ 178 ] is provided for secure the dumbbell clamp to a cable [ 72 ] by use of a hook [ 86 ]. A hand switch receptacle [ 82 ] provides an electrical connector from a hand switch [ 88 ] on the dumbbell clamp to the safety spotting apparatus.
Patent DE-69940054-D1 (DE)
Inventor: HEINILAE MARKO
IPC: H04B1/707
Filed: 1999-12-28
Granted: 2009-01-22
Abstract: The invention relates to a reception method and a receiver to receive signals supplied from a radio path, and the signals include information and each signal which arrives at the receiver is delayed by a unique delay value. The receiver includes a filtering device and a distribution device to determine the strength of a part of a signal delayed by a certain propagation delay by several values of the propagation delay. The distribution device compares the delay differences of the received signals with each other and forms sums of the strengths of the signal parts determined by different values of the propagation delay. The distribution device selects values deviate at least by a predetermined delay difference whose sum of the strengths of the signal parts obtains the highest possible value. The receiver indicates the received information by using the signals selected above.