baber/WOPTO huggingface dataset:
Patent EP-0915835-B1 (EP)
Inventor: DESANTIS NICOLA
IPC: C07C237/52
Filed: 1998-05-19
Granted: 2000-12-20
Abstract: A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7-C16) hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90 DEG  C.
Patent EP-0991530-B1 (EP)
Inventor: FEENEY CARRIE A
IPC: B60C5/14
Filed: 1998-06-08
Granted: 2004-09-22
Abstract: An aqueous barrier coating mixture comprises  (a) an elastomeric polymer;  (b) a dispersed exfoliated layered filler having an aspect ratio greater than 25, and  (c) at least one surfactant,  
wherein the solids content of said mixture is between 1% and 30% and the ratio of polymer (a) to filler (b) is between 20: 1 and 1.2:1; and 
wherein upon applying to a substrate and allowing said mixture to dry to a flexible barrier coating having the same ratio of polymer to filler as in said solution, a coating is formed which provides an at least 10-fold greater reduction in gas permeability than a coating formed of said unfilled polymer (a) alone.
Patent EP-0960908-B1 (EP)
Inventor: KRULL MATTHIAS DR
IPC: C10L1/18
Filed: 1999-05-19
Granted: 2004-09-29
Abstract: Ethylene-derived copolymer mixture giving fuel oils with improved lubricating effect and cold flow properties has one copolymer including hydroxy-containing comonomer and a second containing vinyl esters, ethers or (meth)acrylates. Mixture comprises: (A) 10-90 wt.% copolymer(s) containing structural units derived from ethylene and structural units derived from olefinically unsaturated, hydroxyl-containing compounds; and (B) 90-10 wt.% copolymer(s) containing structural units derived from ethylene and structural units derived from vinyl esters, ethers or (meth)acrylates. Independent claims are also included for the preparation of mineral oils and their distillates by reacting oils and the above mixture and also fuel oils comprising mid-distillates with at most 0.5 wt.% sulfur and a mixture as above.
Patent EP-0970851-B1 (EP)
Inventor: ROSENTHAL DIRK
IPC: B60R5/04
Filed: 1999-07-05
Granted: 2003-10-01
Abstract: A hand grip mounted into the floor of the load space in the rear of a vehicle is flush with the floor when not used and is raised by a spring loaded drive into the operating position. The hand grip (1) is held down by a trip catch (3) and is released by a simple press action. The catch is mechanical or magnetic. For a stronger catch a double catch is used, with the two catch halves linked by a geared drive.
Patent EP-0987532-B1 (EP)
Inventor: HUNSCHE AXEL
IPC: G01L5/24
Filed: 1999-09-03
Granted: 2008-07-02
Abstract: The system measures the resulting stresses; especially a bending stress from the total tightening torque (MA), a torsion or bending stress from the head frictional torque and a compressive stress or strain from the axial preloading (FV), using strain gauge measuring strips (40,50a,60), which are arranged at the force-torque pick-up, so that it forms at least one of the measuring points. The measuring point for the torsion or bending stresses dependent on the head frictional torque is mechanically decoupled from an influence of the compressive stress dependent on the axial preloading force.
Patent EP-1091030-B1 (EP)
Inventor: LAUTERBURG NIKOLAUS
IPC: D03D15/00
Filed: 1999-09-17
Granted: 2003-11-26
Abstract: An awning fabric comprises a base fabric with warp (12) and weft (14) of high light transmission yarns. To produce a gradual change in light transmission along the fabric, the weft includes yarns of low light transmission (16) at variable spacing or of different composition. Independent claims are also included for following methods of producing such fabrics: (a) weft yarns of low (16) and high (14) light transmission alternate and their spacing is changed over a distance of at least 10 cm along the fabric length to obtain a gradual or stepwise light transmission change; (b) similar light transmission changes are obtained by using weft yarns of different composition.
Patent EP-1002839-B1 (EP)
Inventor: KATO SHINICHI
IPC: C09D11/00
Filed: 1999-09-20
Granted: 2003-11-26
Abstract: Disclosed is a black ink composition for ink jet recording, comprising at least carbon black, a black dye, a water-soluble organic solvent, and water, the black dye being a black dye represented by formula (I), C.I. Direct Black 154, or C.I. Direct Black 168: <CHEM> wherein M represents a cation of a group selected from the group consisting of a hydrogen atom, an alkali metal, ammonia, and an organic amine; m is 1 or 2; and n is 0 or 1.
Patent EP-1018443-B1 (EP)
Inventor: CHERN LAI JIANN
IPC: B60B21/08
Filed: 1999-12-28
Granted: 2004-11-10
Abstract: A wheel rim (10) for a bicycle includes an annular slot (11) formed between two peripheral sides (13, 14) each having a number of grooves (21) formed in the outer surface (20) and formed between a number of concentric ribs (22) which are used for engaging with a brake pad (30). The ribs (22) are preferably tooth-shaped. The wheel rim (10) includes two or more concentric bulges (23) formed between the ribs (22) and having a height greater than that of the concentric ribs (22) for engaging with the brake pad (30) and for facilitating the braking operation of the bicycle. <IMAGE>
Patent EP-0983922-B1 (EP)
Inventor: LANDROT ALAIN
IPC: B61F5/32
Filed: 1999-08-03
Granted: 2004-05-12
Abstract: The bogie consists of at least two axles with wheels, at least one frame beam, running from the axles to a part, which is roughly central in the bogie, and axle boxes (4), in which the axles are mounted. The frame beam consists of an interchangeable elastic blade, forming the primary suspension characteristic, and has a region (61) of composite material, at each end of the beam, and which is located within a housing (8), which is connected to the axle box by an inset separator (9).
Patent EP-1064900-B1 (EP)
Inventor: GIACOMETTI CLAUDIO
IPC: B32B7/02
Filed: 1999-07-02
Granted: 2006-04-12
Abstract: A process is described for the production of a composite sheet material comprising a plastic film (F) and a web (V) of textile fibers (T) combined with said plastic film (F). The process comprises the following phases:      a) feeding the plastic film (F) to a lamination station;    b) feeding the web (V) to said lamination station;    c) applying an adhesive to one surface of the film or to one surface of the web;    d) applying the web (V) of un-consolidated textile fibers (T) to said plastic film (F) with the adhesive distributed between the web and the film;    e) laminating the plastic film and the web of unconsolidated textile fibers causing reciprocal adhesion at least in areas between the web of un-consolidated textile fibers and the plastic film by means of said adhesive.    <IMAGE>
Patent EP-0998010-B1 (EP)
Inventor: GUENTENSPERGER WALTER
IPC: H02K1/27
Filed: 1999-10-19
Granted: 2001-12-12
Abstract: The machine has a number of permanent magnets (3) around the rotor periphery, alternating with flux elements (6) made of a material with a high magnetic conductivity and a low electrical conductivity. The rotor has a damping cage (5) of a material with a high electrical conductivity and a low magnetic conductivity, which partially encloses the permanent magnets and the flux elements, via radial struts (5') extending between the latter in the direction of the stator
Patent EP-1060402-B1 (EP)
Inventor: HILLS BRIAN PHILIP
IPC: G01R33/38
Filed: 1999-02-12
Granted: 2005-05-04
Abstract: A nuclear magnetic resonance spectroscopic technique is applied to objects undergoing translational motion for chemical analysis of objects on a conveyor passing through a detector module. The objects are passed through the detector module at a predetermined velocity V, in which there is provided a spatially uniform, constant magnetic field B0, substantially parallel to the direction of the velocity v and a radio frequency field B1 pulse transverse to the field B0. Selected nuclear magnetic resonance parameters from the objects passing through the detector module are then used to determine chemical composition or changes therein.
Patent EP-1059574-B1 (EP)
Inventor: HORIMAI HIDEYOSHI
IPC: G03H1/12
Filed: 1999-02-26
Granted: 2012-08-22
Abstract: L'invention concerne un appareil pour former des hologrammes ou reproduire des images tridimensionnelles, sans aucune restriction quant aux images tridimensionnelles destinées à être reproduites, à la taille des hologrammes, ou à la lumière de référence. Lorsqu'un support d'enregistrement (1) est irradié, un module de commande détermine une figure d'interférence tridimensionnelle permettant de produire une lumière de reproduction correspondant à l'image tridimensionnelle souhaitée, puis divise cette figure d'interférence tridimensionnelle en plusieurs figures d'interférences distinctes, et enfin détermine la lumière de référence d'enregistrement et la lumière d'information d'enregistrement pour chacune de ces figures d'interférences. Lorsque l'on déplace ledit support d'enregistrement (1), celui-ci est irradié par la lumière de référence d'enregistrement et par la lumière d'information d'enregistrement à l'aide d'une tête (10), destinée à se déplacer au moyen d'un VCM (13) pour modifier la position relative de cette tête (10) par rapport au support (1), des parties d'hologrammes étant ainsi formées de manière séquentielle afin de constituer un hologramme complet.
Patent EP-1068652-B1 (EP)
Inventor: OUSSET MICHEL
IPC: G06K19/077
Filed: 1999-03-15
Granted: 2004-03-03
Abstract: L'invention concerne les étiquettes électroniques qui sont associées chacune à un produit pour l'identifier. L'invention réside dans le fait que l'étiquette comprend un dispositif pour modifier l'impédance ramenée sur l'antenne en utilisant une résistance variable de modulation (26') et/ou un condensateur d'accord (16') à capacité variable dont les valeurs sont modifiées par un circuit (30) en fonction de certains paramètres tels que la tension d'alimentation Vdd, les conditions d'utilisation de l'étiquette, les messages binaires à transmettre au dispositif de lecture. Il est ainsi possible d'adapter les valeurs de la résistance de modulation (26') et du condensateur d'accord (16') pour obtenir un fonctionnement optimal en regard de l'application envisagée de l'étiquette électronique.
Patent EP-1064281-B1 (EP)
Inventor: COZZI PAOLO
IPC: C07D403/14
Filed: 1999-03-17
Granted: 2005-05-25
Abstract: Compounds which are benzoheterocyclic distamycin derivatives of formula (I), wherein n is 2, 3 or 4; A is a heteroatom selected from O and S or is a group NR, wherein R is hydrogen or C1-C4 alkyl; B is CH or N; R1 is hydrogen or C1-C4 alkyl; G is selected from the group consisting of (a, b, c, d, e, f, g, h, i, j), and -C=N; wherein R5, R6, R7, R8, R9, R10, R11 and R12 are, independently from each other, hydrogen or C1-C4 alkyl; T is a group of formula (II) or (III) as defined above, wherein p is 0 or 1; R2 and R3 are, independently from each other, hydrogen, C1-C4 alkyl optionally substituted by one or more fluorine atoms, or C1-C4 alkoxy; R4 is C1-C4 alkyl or C1-C3 haloalkyl; X1 and X2 are halogen atoms or pharmaceutically acceptable salts thereof; provided that at least one of R5, R6 and R7 is alkyl; are useful as antitumor agents.
Patent EP-1137532-B1 (EP)
Inventor: GOLLEDGE ADRIAN D
IPC: C09J7/02
Filed: 1999-03-31
Granted: 2004-12-15
Abstract: A release liner (10) which includes a metal layer (12) with a release agent (14) attached to a side of the metal layer (12). The release agent (14) is exposed to releasably receive an article (15). The metal layer (12) has a thickness sufficient to prevent a laser from penetrating through the metal layer (12) as the article (15), attached to liner (10), is laser cut.
Patent EP-1084298-B1 (EP)
Inventor: KLAS ERNST
IPC: D21H25/10
Filed: 1999-03-23
Granted: 2003-06-04
Abstract: The invention relates to a device for applying a coating substance to a continuous paper web in a process for producing abrasion-resistant laminates for manufacturing decorative paper. The coating substance consists of a viscous mixture of melamine resin and alphacellulose to which particles of corundum are added, and is applied to the visible surface of the paper. The inventive device includes a deflector roll (2) on which the paper web (1) lies in an area in which it loops around; a metering roll (6) which is arranged parallel to the deflector roll (2) and forms the boundary of a gap with the same, and which is driven synchronously or almost synchronously with the deflector roll; a slit nozzle (7) for applying the coating substance either directly to the paper web (1) on the deflector roll (2) or to the metering roll (6); and a doctor blade of a rectangular piece (9) of flexible rubber type material. This material is fixed on one side by its back edge, parallel to the axes of the two rolls (2,6) and lies loosely on the upper end of the paper web (1) running off of the deflector roll (2).
Patent EP-1082316-B1 (EP)
Inventor: SISTI NICHOLAS J
IPC: C07D305/14
Filed: 1999-04-29
Granted: 2004-06-23
Abstract: The present invention relates to a method of producing paclitaxel or a paclitaxel analog comprising the esterification of C-7, C-10 di-CBZ 10-deacetylbaccatin III with an N-carbamate protected, C-2-protected 3-phenyl isoserine side chain. The C-7, C-10 carbobenzyloxy groups are then replaced with hydrogen and an acyl group is substituted at the C-3' nitrogen. The resulting compound is acylated at the C-10 hydroxyl position, and deprotected at the C-2' position by replacing the hydroxyl protecting group with hydrogen to produce paclitaxel or a paclitaxel analog. The present invention also relates to alternative methods of acylating a 10-hydroxy paclitaxel analog. The first method comprises dissolving a 10-hydroxy paclitaxel analog in an acceptable ether solvent therefor to form a first solution at a first temperature. The first solution is then cooled to a second temperature, and an alkali base is added to form an intermediate compound having a metal alkoxide at the C-10 position thereof, after which an acylating ageht is then added. The second method comprises dissolving a 10-hydroxy paclitaxel analog in an acceptable ether solvent therefor. An alkali salt is added, and a trialkyl amine base or pyridine is next added, followed by the addition of an acylating agent. The present invention is additionally directed to a C-10 metal alkoxide chemical intermediate for use in producing paclitaxel or paclitaxel analogs.
Patent EP-1003496-B1 (EP)
Inventor: STEINER MITCHELL S
IPC: A61K31/137
Filed: 1999-05-07
Granted: 2004-11-24
Abstract: The invention relates to the chemoprevention of prostate cancer and, more particularly, provides a chemopreventive agent, e.g. toremifene citrate, for use in treating prostate intraepithelial neoplasia (PIN), especially high grade prostate intraepithelial neoplasia (HGPIN).
Patent EP-1085884-B1 (EP)
Inventor: STIEFEL THOMAS
IPC: A61K31/495
Filed: 1999-05-31
Granted: 2005-03-09
Abstract: The present invention relates to the use of selenium and/or a derivative thereof in combination with one or more cytostatics.It is the object of the present invention to provide a possibility of enhancing the effect of antitumor drugs, and to provide said drugs in a suitable form of administration.Said object is achieved by using selenium and/or at least one selenium compound for enhancing the effect of one or more cytostatics. This combination results in a synergistic, i.e. superadditive, enhancement of the effect. Furthermore, the present invention provides a kit containing selenium and/or at least one selenium compound and one or more cytostatics as a combination preparation for cytostatic therapy. The present invention can be used efficiently against various types of tumor cells, but especially against large-cell and small-cell bronchial carcinomas, adenocarcinomas, pancreatic carcinomas, prostatic carcinomas and hypemephromas.
Patent EP-1090117-B1 (EP)
Inventor: KENNEDY GIULIA C
IPC: C12Q1/68
Filed: 1999-06-22
Granted: 2010-04-07
Abstract: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
Patent EP-1107844-B1 (EP)
Inventor: HECHT GIL
IPC: B23C5/22
Filed: 1999-08-04
Granted: 2003-11-26
Abstract: A replaceable cutting head is adapted for co-axial coupling thereof, along a coupling axis, with a tool shank in a self-clamping fashion. Both the cutting head and the tool shank have a mounting portion comprising a centering section and a positioning section. The centering section is formed with a peripheral centering surface which extends circumferentially with respect to the coupling axis and has a substantially conical shape at least at two portions thereof. The positioning section has at least two peripherally disposed and circumferentially extending and spaced apart positioning surfaces adapted for the provision of an axial support of the cutting head on the tool shank. Each positioning surface is inclined with respect to the coupling axis so that an axial distance therefrom to a broad end of the peripheral centering surface increases in a direction generally corresponding to the direction of cutting forces acting on the cutting edge during a cutting operation. One of the positioning and centering sections is formed with at least two circumferentially spaced apart fixation wings with, respectively, either the positioning surfaces and or the portions of the centering surface belonging thereto.
Patent EP-1107763-B1 (EP)
Inventor: CHEN CHIH-MING
IPC: A61K9/22
Filed: 1999-08-31
Granted: 2004-06-23
Abstract: A controlled release pharmaceutical tablet containing antihyperglycemic drug and a hypoglycemic drug that does not contain an expanding or gelling polymer layer and comprising a core containing the antihyperglycemic drug and the hypoglycemic drug, a semipermeable coating membrane surrounding the core and at least one passageway in the membrane to allow the drugs to be released from the core.
Patent EP-1110429-B1 (EP)
Inventor: STEINEL HEINRICH-WOLFGANG
IPC: H05B3/46
Filed: 1999-08-27
Granted: 2003-05-02
Abstract: L'invention concerne un dispositif de chauffage électrique pour chauffer un fluide, en particulier un courant d'air. Le dispositif comporte un dispositif support pour loger un corps chauffant hélicoïdal. Le dispositif support présente une pluralité d'éléments support pouvant être placés axialement les uns à côté des autres pour produire au moins un canal d'écoulement traversant pour le fluide, le canal s'étendant axialement. Le dispositif selon l'invention comporte aussi un capteur électrique de température situé à la sortie. Les fils d'alimentation du capteur sont dirigés vers un module de connexion situé à l'entrée. Le module de connexion, qui peut être connecté à une électronique de commande, comprend un module de mémoire affecté individuellement au dispositif de chauffage. Ce module de mémoire est configuré pour le stockage non volatile de valeurs individuelles de mesure et de test du dispositif de chauffage, incluant le stockage d'une valeur de test individuelle du capteur de température à une température de fonctionnement.
Patent EP-1152242-B1 (EP)
Title: Container for immunoassay
Inventor: TANAKA HAYAO
IPC: B01L3/00
Filed: 1999-10-28
Granted: 2005-12-28
Abstract: A container for an immunologic assay in which the saturation adsorption of molecules for use in the assay is 1 x 10<-1> pmol/cm<2> or lower. The container is free from non-specific adsorption causative of reagent loss, sensitivity decrease, and precision decrease.
Patent EP-1083886-B1 (EP)
Inventor: FLEISCHER WOLFGANG
IPC: A61K31/055
Filed: 1999-05-27
Granted: 2003-04-02
Abstract: Use of an anti-inflammatory agent such as povidone iodine for the preparation of a pharmaceutical composition for the treatment of diseases of the lower respiratory tract which are susceptible to the administration of such agents.
Patent EP-1124501-B1 (EP)
Inventor: BEATY KEITH
IPC: A61C8/00
Filed: 1999-10-22
Granted: 2007-06-06
Abstract: L'invention concerne un pilier support qui s'utilise avec un implant dentaire constitué d'une partie céramique, d'une vis et d'une partie métallique. La partie céramique est adaptée pour recevoir et soutenir une prothèse. Elle comprend une région sus-gingivale formant une protubérance au-delà de la gencive et une extrémité sus-gingivale s'étendant à l'intérieur de la gencive. La partie céramique est traversée d'un passage. Selon une forme de réalisation, ce passage rétrécit pour former un épaulement entièrement constitué de céramique. La vis est conçue pour s'engager dans un alésage interne fileté de l'implant et s'insérer à travers le passage. La vis comporte une tête et une partie filetée. La tête de la vis repose complètement sur l'épaulement. La partie métallique comprend une section inférieure et une section supérieure s'étendant à l'intérieur du passage. La partie métallique aboute l'extrémité sus-gingivale de la partie céramique. La section inférieure est adaptée pour recevoir et se fixer à la protubérance correspondante de l'implant dentaire. La partie métallique présente une ouverture donnant accès à la vis.
Patent EP-1143955-B1 (EP)
Inventor: ERION MARK D
IPC: A61K31/421
Filed: 1999-12-22
Granted: 2005-07-27
Abstract: Pharmaceutical compositions containing an FBPase inhibitor and an insulin sensitizer are provided as well as methods for treating diabetes and diseases responding to increased glycemic control, an improvement in insulin sensitivity, a reduction in insulin levels, or an enhancement of insulin secretion.
Patent EP-1137622-B1 (EP)
Inventor: LATYPOV NIKOLAI
IPC: C07C205/02
Filed: 1999-12-08
Granted: 2003-07-30
Abstract: A method of preparing dinitromethane salts usable as intermediate products add starting material for production of explosives and propellants. Substituted 1,2-diazoles, 1,2,4 -triazoles or 1,3-diazines, such as barbituric acid, are nitrated to obtain a gem-dinitro group on a carbon atom in the heterocyclic ring. The product is hydrolysed to split off dinitromethane which is neutralised with a neutralising agent to obtain a corresponding salt of dinitromethane.