baber/WOPTO huggingface dataset:
Patent DK-2016930-T3 (DK)
Inventor: DEGRAW JULI
IPC: A61K39/00
Filed: 2002-02-19
Granted: 2014-12-08
Abstract: T cell responses are often diminished in humans with a compromised immune system. We have developed a method to isolate, stimulate and expand naïve cytotoxic T lymphocyte precursors (CTLp) to antigen-specific effectors, capable of lysing tumor cells in vivo. This ex vivo protocol produces fully functional effectors. Artificial antigen presenting cells (AAPCs; e.g. from Drosophila melanogaster) transfected with multiple human HLA class I cancer antigens and defined accessory molecules, are used to stimulate CD8+ T cells from both normal donors and cancer patients. The class I molecules expressed to a high density on the surface of the Drosophila cells are empty, allowing for efficient loading of multiple peptides that results in the generation of polyclonal responses recognizing tumor cells endogenously expressing the specific peptides. The responses generated are robust, antigen-specific and reproducible if the peptide epitope is a defined immunogen. This artificial antigen expression system can be adapted to treat most cancers in a significant majority of the population.
Patent DK-2906563-T3 (DK)
Inventor: MC GOWAN DAVID CRAIG
IPC: C07D487/04
Filed: 2013-10-09
Granted: 2018-06-06
Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
Patent DK-2905335-T3 (DK)
Inventor: TSURUSHITA NAOYA
IPC: G01N33/574
Filed: 2013-10-03
Granted: 2018-03-12
Abstract: The present invention provides: an antibody capable of reacting specifically with hDlk-1 and having an anti-tumor activity in vivo (i.e., an anti-hDlk-1 antibody, particularly a humanized antibody); a fragment of the antibody; a hybridoma capable of producing the antibody; a complex of the antibody or a fragment of the antibody and a medicinal agent; a pharmaceutical composition containing the antibody or the like; a therapeutic agent for a tumor; a diagnostic agent for a tumor; an agent for inducing the apoptosis of a tumor cell; a method for treating a tumor; a method for detecting a tumor; a method for inducing the apoptosis of a tumor cell; a kit for detecting and/or diagnosing a tumor; a kit for inducing the apoptosis of a tumor cell; and others.
Patent DK-2938332-T3 (DK)
Inventor: YOON SANG PHIL
IPC: A61K47/30
Filed: 2013-12-27
Granted: 2018-06-06
Abstract: Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) at least one phospholipid; c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety; and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.
Patent DK-3038851-T3 (DK)
Inventor: RIZZOLI ANDREA EMILIO
IPC: H02J7/02
Filed: 2014-08-27
Granted: 2018-06-18
Abstract: A method for recharging an accumulator of an electric vehicle is disclosed including recording information on past usages of the accumulator locally at a point of connection of the accumulator to a grid; locally estimating information on a future usage of the accumulator, taking in input the information on past usages; and locally programming an energy flow between the grid and the accumulator on the base of the estimated information.
Patent DK-0385357-T3 (DK)
Inventor: AMMERMANN EBERHARD DR
IPC: C07C323/12
Filed: 1990-02-26
Granted: 1992-06-29
Abstract: Ortho-substituted 1-napthyl ethers of the formula   <IMAGE> (I) where X is CH or N, Y is saturated or unsaturated alkylene and R is aryl, aryloxy, arylthio or arylalkoxy, the aromatic ring being substituted or unsubstituted, and fungicides containing these compounds.
Patent DK-0409045-T3 (DK)
Inventor: CIABATTI ROMEO
IPC: A61P31/04
Filed: 1990-07-10
Granted: 1997-12-22
Abstract: Pentapeptide antibiotics of the formula <CHEM> wherein W, Z, X1, X2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glycopeptide antibiotics), Y represents a carboxyacid group, a functional derivative of said carboxyacid group or a hydroxymethyl group. The invention includes the salts of the above represented pentapeptide antibiotics with acids or bases as well as their inner salts. The compounds are obtained by reductive cleavage of the peptidic bond between the second and the third aminoacid of the seven aminoacid chain of dalbaheptides (glycopeptide antibiotics). The inventions concerns also the reductive cleavage process which implies using an alkali metal borohydride as the reagent. The compounds show antibacterial activity against staphylococcal and streptococcal strains.
Patent DK-0426978-T3 (DK)
Inventor: REYNOLDS THOMAS DR-ING
IPC: B01D53/34
Filed: 1990-09-14
Granted: 1996-07-29
Abstract: In this process for selective non-catalytic reduction of the pollutant emission from oil-fired boiler plants, chemical compounds affecting the combustion process are added to the liquid fuel or to the combustion air, including salts of organic acids, such as naphthenates, octoates and tallates, sulphonic acid salts, salts of saturated or unsaturated fatty acids, oleic acids, tall oil with metals from the group comprising K, Ba, Mg, Ca, Ce, Mn, Fe and rare earth metals, organometal compounds such as carbonyl compounds, mixed cyclopentadienyl-carbonyl compounds or aromatics complexes of the transition metals Fe or Mn in solutions miscible with the liquid fuel. To minimise the NOx values in the waste gas and the dust loading, coupled with economical chemicals consumption, a reducing agent is added to the firing chamber (burner chamber) via a boiler-dosing system, using a liquid or also gaseous carrier stream, as an aqueous solution of urea or also urea precursors such as ammonia or ammonium carbonate, which can also contain further constituents such as alkanols, alkanecarboxylic acids, alkanals or alkanones. <IMAGE>
Patent DK-0426176-T3 (DK)
Inventor: LICHTENTHALER FRIEDER W
IPC: C09K23/56
Filed: 1990-10-31
Granted: 1994-08-01
Abstract: The invention relates to a process for converting isomaltulose into 5-( alpha -D-glucopyranosyloxymethyl)furan-2-carboxaldehyde (GMF), specifically by heat treatment of its solution in the presence of an acidic ion exchanger batchwise or by percolation through a column packed with ion exchangers. 
<??>The invention also relates to the preparation of derivatives and secondary products of GMF according to the general formula (I) 
<IMAGE>
 in which R<'> is a hydrogen atom, an acyl radical or alkyl radical, and X is either -CH2OH, -COOH, -C(H)=NOH, -CN, -CH2NHR<''> or CH=CR<''>R<'''> (with R<''> = H, acyl radical, aryl radical or alkyl radical with up to 20 C atoms and R<'''> = H, -NO2, -CN, -COOalkyl or acyl). 
<??>The invention furthermore relates to the use of the compounds for preparing surface-active substances.
Patent DK-0413620-T3 (DK)
Inventor: LE FLOCH LOUIS
IPC: B65B31/02
Filed: 1990-08-02
Granted: 1994-02-21
Abstract: Box (1) for insulating from the surrounding atmosphere, for products which are in bulk or pre-packed in packages (12) to be sealed, of the type comprising a box body (2) and an access door (3) with leaktight closure, provided with openings and sealing means comprising a stopper (6) with a manoeuvring head and an end part (8) in which at least one passage (11) is provided between the inside of the box (1) and the external atmosphere, in a first position of partial pushing in of the stopper, and a body part (10) adjacent to the head (7) closing the opening (5) in a leaktight manner in a second position of complete pushing in of the said stopper. Applications to the insulation from the atmosphere of products treated in special atmospheres or under reduced pressure. <IMAGE>
Patent DK-0478670-T3 (DK)
Inventor: IRVING MARK EDWARD
IPC: G03C1/035
Filed: 1990-06-19
Granted: 1993-06-14
Abstract: Radiation sensitive silver halide grains are described which comprise at least 90 mole percent silver iodide and which have the morphological configuration of four hexagonal bipyramids, the four bases of which are joined to form a common tetrahedron. A process is described for the preparation of such grains.
Patent DK-0576724-T3 (DK)
Inventor: CASSANO NICOLA
IPC: B62K5/00
Filed: 1992-10-15
Granted: 1999-02-08
Abstract: The item is a three-wheeled cart with an electrical motor for the transport of golf equipment and one person. It is equipped with steerage which allows one to drive the cart while sitting on the seat, while standing on the board placed between the rear wheels, or while walking behind the cart itself. <IMAGE>
Patent DK-0517424-T3 (DK)
Inventor: WESLER JOHN R
IPC: A23C9/152
Filed: 1992-05-28
Granted: 1995-11-27
Abstract: The present invention provides an aqueous shelf-stable beverage product comprising: water; milk solids, the milk fat content of which is at least about 15% by weight and the milk protein content of which is at least about 25% by weight based on the total weight of milk solids, the milk solids content of the beverage product being at least about 1% by weight of the beverage product; an acidic flavoring agent; a two component stabilizing system comprising a first component comprising monoglycerides and up to 10% by weight diglycerides based on the weight of the first component, and a second component comprising carrageenin or pectin or both; a buffering system comprising disodium phosphate and potassium hydroxide, said potassium hydroxide being formed by the thermal decomposition in the beverage product of potassium bicarbonate, said disodium phosphate and potassium hydroxide being present in an amount such that said shelf-stable beverage product has a pH of about 6.3 to about 6.5. The present invention also provides a method for making a shelf-stable beverage product comprising the steps of: providing a homogenized milk mixture having the two component stabilizer system; providing a buffered aqueous flavoring solution containing the acidic flavoring agent and the buffering system having a pH of from 6.8 to 7.2; mixing the homogenized milk mixture and the aqueous flavoring solution to form an intermediate liquid mixture having a pH of from 6.8 to 7.2; and heating the intermediate liquid mixture at a temperature and for a time sufficient to thermally decompose substantially all of the potassium bicarbonate to potassium hydroxide and carbon dioxide such that the pH of the intermediate mixture is from 6.3 to 6.5 and sufficient to form the shelf stable beverage product.
Patent DK-0507672-T3 (DK)
Inventor: RENAUD ALAIN
IPC: A61K31/445
Filed: 1992-03-31
Granted: 1997-12-15
Abstract: New derivatives of N-cyclohexylbenzamides of formula: 
<IMAGE>
 where 
 
  R1 represents an alkoxy residue which can be cyclised over the aromatic nucleus; 
  R2, R3 and R4 each independently represent a hydrogen, a halogen, an alkoxy group, an amino group, an alkylamino group or an alkylcarbonylamino group, 
  Z represents a variously substituted piperidyl group; 
 and their addition salts with pharmaceutically acceptable acids. 
<??>The compounds of formula I are potent stimulants of the gastrointestinal motor function.
Patent DK-0507755-T3 (DK)
Inventor: OKADA GORO
IPC: B65G47/68
Filed: 1992-03-31
Granted: 1996-10-28
Abstract: A conveying system splits a stream of articles into three substreams. The system includes an infeed conveyor (12) which conveys articles and aligns their centers of gravity along a central axis. A steering mechanism (16) receives the articles and steers them selectively in one of three directions toward an outfeed conveyor arrangement (14). The outfeed conveyor arrangement (14) includes a mouth (90) formed by the intersection of three outfeed conveyors (14) arranged to receive articles from the steering rollers (20,22,24). A centrally located one (92) of the outfeed conveyors (92,94,96) occupies less than one-third of the transverse width of the mouth (90), and each of the other two outfeed conveyors (94,96) occupies more than one-third of the transverse width of the mouth (90). The steering rollers (20,22,24) are turned by a fluid actuated mechanism (60) which comprises two fluid cylinders (62,64) affixed together in back-to-back relationship.
Patent DK-0600425-T3 (DK)
Inventor: BABROWICZ ROBERT
IPC: B32B27/32
Filed: 1993-11-29
Granted: 2000-08-21
Abstract: The present invention is directed to a heat-shrinkable, thermoplastic film or bag which contains at least one homogeneous ethylene alpha-olefin copolymer with at least some limited long chain branching. Oriented films made in accordance with the present invention exhibit improved processability as well as improved physical properties such as excellent optics and impact resistance. A homogeneous ethylene alpha-olefin with long chain branching may be present in a monolayer film either alone or in a blend or may be included in one or more layers of a multilayer film in accordance with the present invention.
Patent DK-0568167-T3 (DK)
Inventor: GOTTSCHALK ACHIM DR ING
IPC: B61L17/00
Filed: 1993-04-14
Granted: 1995-07-10
Abstract: For the online determination of the rolling resistance of a train section, the actual running path/running time behaviour of the section is recorded during freewheeling; during this process, the times when individual axles of the section pass over contacts are determined. In addition, the computational time points when the contacts are passed over are determined from the simulation of the process. If the actual running behaviour of a section deviates from its computationally calculated running behaviour, false values for the variables taken into account in a simulation model are set in the simulation model. By listing the numerical values for the influence which changes to these variables have on the computationally calculated times of passing over contacts, in a matrix and application of the orthogonalisation method to this matrix, correction values for the variables are obtained. Using these correction values, new times of passage over the contacts and new values for the influence of parameter changes are determined and, from these, new correction values are determined again for the variables. These processes are repeated until a sufficiently accurate adaptation of the computationally determined running path/running time behaviour to the appropriate running path/running time behaviour is obtained. The value of the rolling resistance which is then used for the simulation gives the actual rolling resistance of the train section in question. <IMAGE>
Patent DK-0576217-T3 (DK)
Inventor: LANGTON CHRISTIAN MCDONALD
IPC: A61B8/08
Filed: 1993-06-18
Granted: 1999-07-05
Abstract: An ultrasound bone analysis apparatus comprises locating means (14) such as a foot bed, for locating a patient's body part in a predetermined position, and a pair of ultrasonic transducers (20, 22) for use in taking ultrasonic measurements of the body part. Each transducer includes a body part contacting portion (19), such as a silicone pad, for ultrasonic contact with the body part. The apparatus further provides means for moving the contacting portion (19) of each transducer relative to the body part. Preferably the apparatus includes means (50,51,52,54) for controlling the pressure with which the transducers (20,22) contact the body part. This allows the compression of the body part contacting portion (19) to be maintained at a constant value and therefore for the measurements become more accurate. <IMAGE>
Patent DK-0624196-T3 (DK)
Inventor: RUOSLAHTI ERKKI I
IPC: A61P35/00
Filed: 1993-02-01
Granted: 1997-11-03
Abstract: In accordance with the present invention, there is provided a novel synthetic polypeptide derived from the first type III repeat of fibronectin. The synthetic polypeptide of the invention encompasses a fibronectin-fibronectin binding site, and is capable of inhibiting fibronectin matrix assembly. In contrast to previously identified fibronectin fragments that block fibronectin matrix assembly by blocking an initial event in matrix assembly (i.e., fibronectin binding to cells), the invention polypeptide appears to inhibit an intermediate step in matrix assembly, i.e., fibronectin self-association prior to the disulfide cross-linking that stabilizes the fibronectin matrix.
Patent DK-0681500-T3 (DK)
Inventor: SUNDHOLM GOERAN
IPC: A62C37/16
Filed: 1993-04-21
Granted: 1999-09-27
Abstract: PCT No. PCT/FI93/00164 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 21, 1993 PCT Pub. No. WO93/21998 PCT Pub. Date Nov. 11, 1993Fire-fighting equipment has a release device (7) arranged to be activated at a predetermined release temperature, and an element (8) of memory metal immediately close to the release device and arranged to change shape at a predetermined memory temperature to close an electric circuit (10-9-8-5-2-11) for heating the memory metal element (8) and, thereby, the release device to the release temperature, whereby to effect a fast release action.
Patent DK-0650546-T3 (DK)
Inventor: VIRTANEN ANTTI JAAKKO
IPC: E06B3/58
Filed: 1993-06-07
Granted: 1998-04-27
Abstract: The present invention relates to a lead-through structure for a wall, said structure comprising two frame like parts interconnecting from each side of said wall, a first male part (10) comprising a set of locking tongues (11, 11A) extending from a circumferential plane oriented in the general direction of said wall towards said wall and extending in the direction of corresponding edges of said frame, said locking tongues (11, 11A) interacting with counter slots located, recessed against said wall, in a female second part (1) and being directed in the direction of said edge of said frame. Each locking tongue (11, 11A) comprises at least one locking claw (17) extending essentially in the direction of a corresponding edging (3) of said frame, said claw (17) extending from the side surface of said tongue. Each counter slot (6) comprises at least one counter shoulder (7) co-operating with said locking claw (17), said counter shoulder (7) also extending in the direction of said corresponding edging (3) of said frame. The invention is especially useful as a window framing in walls or the like having a sandwich structure.
Patent DK-0633245-T3 (DK)
Inventor: SESTELO JOSE P
IPC: C07C401/00
Filed: 1994-05-18
Granted: 1996-12-23
Abstract: The invention relates to a new vitamin D compound of the general formula <CHEM>  wherein: R2 is a (C1-C3)alkyl group, a hydroxy(C1-C3)alkyl group, a (C1-C2)alkoxymethyl group or a (C2-C3)alkenyl or alkynyl group; R3 is a branched or non-branched, saturated or unsaturated aliphatic 3- to 5-membered hydrocarbon or oxahydrocarbon biradical, having at least 3 atoms in the main chain and being optionally substituted with one or more substituents selected from epoxy, fluoro and hydroxy;     iPr is an isopropyl group; and     A and B are each individually hydrogen atoms or methyl groups, or     A and B form together a methylene group. The invention further relates to a method of preparing these compounds and to their use in pharmacotherapy and cosmetics. <IMAGE>
Patent DK-0706796-T3 (DK)
Inventor: NAMIKI TAKAYUKI
IPC: C07D213/74
Filed: 1994-04-28
Granted: 2001-03-26
Abstract: A dopamine (DA) reincorporation inhibitor containing a compound represented by general formula (1) or a physiologically acceptable salt thereof as the active ingredient, wherein R<1> and R<2> represent each hydrogen or halogen; R<3> represents hydrogen, alkyl or acyl; R<4> represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl; Ar represents optionally substituted phenyl or a nitrogenous monocyclic heteroaromatic group; m represents a number of 1 to 5; and n represents a number of 0 to 5. This inhibitor does not produce any side effect, is safe, has potent activities of inhibiting DA reincorporation and enhancing autonomic movement, and is very useful for treating Parkinson's syndrome believed to be a disease caused by DA deficiency. <CHEM>
Patent DK-0667369-T3 (DK)
Inventor: BASTIOLI CATIA
IPC: C08L3/00
Filed: 1995-01-26
Granted: 2002-10-07
Abstract: Expanded articles of biodegradable plastic material are produced by agglomerating expanded particles with density from 0.1. to 0.003 g/gm<3> and size from 0.5 to 10 mm of diameter, made of a material comprising:  from 50 to 95% by weight of thermoplastic starch; from 0.5. to 45% by weight of at least one thermoplastic polymer; from 2 to 20% by weight of water;  characterized in that the foamed particles are prepared through a route which consists of compressing/depressurising non foamed particles or through a heating treatment by microwave. <IMAGE>
Patent DK-0671222-T3 (DK)
Inventor: WILLIBALD JOSEF
IPC: B07B1/10
Filed: 1995-02-16
Granted: 2000-11-13
Abstract: The sieve assembly, for compost, has a dosing unit as a vertical filling shaft (6,6a) leading downwards with an angled continuous drag conveyor (7) fitted with bars or ribs (7a). The passage gap (6b) is between the end of the drag conveyor and the neighbouring filing shaft wall (6a). The recirculating mesh belt (8) is below the drag conveyor (7,7a), at a horizontal gap (H) from it, together with its drive (10), deflection (9,11) and tensioning (12) rollers. A beating/vibrating system is directly below the mesh belt area (8a), with eccentric beaters (14) on a powered rod (13). Two removal conveyors (15,16) are below the mesh belt (8a) and beating unit (13,14) to collect (15) the material falling through the belt (8a) and carry it off (16) outwards to the side at right angles.
Patent DK-0709531-T3 (DK)
Inventor: FISCHER WILLIBALD
IPC: E04G11/36
Filed: 1995-09-08
Granted: 2000-05-08
Abstract: The expendable component (E) has spacers (11) protruding from one side of the roughly vertical protective surface (10) in which the apertures (14) are formed. The spacers secure it to one or more reinforcing members (4), and leave passages (19) free through which filling with concrete takes place. An insulating plate (P) can be fixed to the protective surface on the opposite side to the spacers. The protective surface can be a strip with lengthwise and transverse struts with a sheet-metal plate fixed between them and preferably of expanded metal to form the apertures. The spacers are fixed and preferably welded to the struts.
Patent DK-0686800-T3 (DK)
Inventor: STUCCHI GIOVANNI
IPC: F16L29/04
Filed: 1995-05-31
Granted: 1999-10-18
Abstract: A quick-coupling fitting for pipes comprises a female element (1) and a male element (2) that can be coupled together, formed by fixed parts (3, 4, 6, 9; 29, 32, 35) and axially sliding parts (10, 15; 37, 44). The fitting is provided with a valve (71; 80) apt for intercepting a communication port (79) between a conduit (65) and a passage port (78) for the fluid in the initial stages of the coupling action and for opening it in the final stages of the coupling action. A seal (40) of a fixed internal casing (32) is covered by a sliding bush (10) whatever is the axial position assumed by the bush (10) during the initial and final stages of the coupling action. <IMAGE>
Patent DK-0734257-T3 (DK)
Inventor: STROPPOLO FEDERICO
IPC: A61K31/19
Filed: 1994-12-07
Granted: 2002-06-24
Abstract: PCT No. PCT/EP94/04066 Sec. 371 Date May 30, 1996 Sec. 102(e) Date May 30, 1996 PCT Filed Dec. 7, 1994 PCT Pub. No. WO95/16445 PCT Pub. Date Jun. 22, 1995A pharmacuetical composition in the form of cream, foam or stick containng 2.5-10% by weight (S)-2-(4-isobutylphenyl)propionic acid, 20-30% by weight and ethanol and 5-50% by weight propylene glycol, the ratio of ethanol to propylene glycol being 0.6-1 to 4:1.