baber/WOPTO huggingface dataset:
Patent HU-E035662-T2 (HU)
Title: Compositions and methods for treating cancer
Inventor: SHUMWAY STUART DENHAM
IPC: C12Q1/68
Filed: 2013-11-22
Abstract: FIELD: medicine. 
     SUBSTANCE: group of inventions relates to medicine and can be used to treat a patient with a malignant tumour associated with a WEE1 kinase. To this end, the patient undergoes measurement of the expression level of the PKMYT1 gene in a biological sample containing malignant cells obtained from said patient and in a control sample. Further, it is determined whether expression level of the PKMYT1 gene in said sample from the patient is higher or lower than the expression level in said control sample. Said patient is then selected for treatment with a WEE1 inhibitor if the PKMYT1 level from the patient’s sample is lower than in the control sample. And the patient selected for treatment of a malignant tumour is injected with a WEE1 inhibitor. Also disclosed is a method for treating a patient with a malignant tumour associated with a WEE1 kinase, where the patients are characterised by low expression levels of PKMYT1. 
     EFFECT: group of inventions provides treatment of a malignant tumour in patients with low expression levels of PKMYT1. 
     13 cl, 20 dwg, 9 ex
Patent TR-200000846-T2 (TR)
Title: Dijital uydudan yapılan doğrudan yayın.
Inventor: CAMPANELLA S JOSEPH
IPC: H04L27/18
Filed: 1997-10-31
Abstract: Bir uydu dogrudan yayin sistemi, yayin programlarinin bitlerini, bir çati içine toplanan, asil deger fazlaliklari içine toplamaktadir. Çatilar, asil oran kanallarinin bir çoklugu içine birden fazla mesajin gönderilmesini önleyen sembollere bölünmektedir. Asil oran kanallari, bir uyduya iletim için, tekabül eden, yayin frekanslarina birden fazla mesajin gönderilmesini önlemektedir. Bir gövde-üzeri (birden fazla mesajin gönderilmesini önleyen cihaz, yukari-link sinyallerini sembollerin zaman bölümlü birden fazla mesaj göndermis akimlari içine ayirmaktadir. Bir faz farki manüple demodülatörü, sembollerin, dijital temel bant bilgileri içinde ayarini bozmaktadir. Uydu yükü, sembolleri, iki ping-pong tampon ve bir yöneltme dügmesi kullanarak, zaman bölümlü birden fazla mesaj göndermis bilgi akimlari içine çevirmektedir. Alicilar, TDM akimlarini, uydu tarafindan saglanan çati baslangiçlari kontrol kanallari ve yayin istasyonlari tarafindan saglanan kontrol basliklari        DEVAMI VAR
Patent TR-200001423-T2 (TR)
Title: Erimiş paroksetin içeren yeni formülasyonlar
Inventor: GHAZAWI AHMAD
IPC: A61P25/00
Filed: 1998-11-18
Abstract: Paroksetinin kati, yari kati ya da sivi bir tasiyici içinde bulundugu Paroksetinin farmasötik formülasyonlari sunulmustur. Çözeltiler kapsülleri doldurmak için kullanildigi gibi kati çözeltiler de tablet ya da pelletler gibi kendi basina kullanilabilecek sekillere getirildi. Kapsamda ayrica, paroksetini yaglar ve/veya lipidler içinde çözmek için bir çözücü maddenin kullanildigi yeni sivi formülasyonlar ve anhidre ya da hidrofobik tasiyicilar ya da yardimci maddelerin kullanimi ile hemihidrata dönüsen baska paroksetin formlarindan kaçinmak için metodlar da bulunmaktadir.
Patent TR-200003292-T2 (TR)
Inventor: ARMOUR KATHRYN LESLEY
IPC: A61K48/00
Filed: 1999-05-07
Abstract: Disclosed are binding molecules which are recombinant polypeptides containing: (i) a binding domain capable of binding a target molecule, and (ii) an effector domain having an amino acid sequence substantially homologous to all or part of a constant domain of a human immunoglobulin heavy chain; characterized in that the binding molecule is capable of binding the target molecule without triggering significant complement dependent lysis, or cell mediated destruction of the target, and more preferably wherein the effector domain is capable of specifically binding FcRn and/or FcgammaRIIb. These are generally based on chimeric domains which are derived from two or more human immunoglobulin heavy chain CH2 domains domains. In preferred embodiments the regions 233-236, and 327-331, are modified, as are further residues to render the molecule null allotypic. Also disclosed are nucleic acids, host cells, production processes and materials, and uses. Pharmaceutical preparations are also disclosed.
Patent TR-200202096-T2 (TR)
Title: Sitalopram hazırlamak için yöntem
Inventor: ROCK MICHAEL HAROLD
IPC: C07B61/00
Filed: 2001-03-01
Abstract: Bulus sitalopram hazirlamak için bir yöntemle ilgilidir ki sözkonusu yöntem bir formül (II) bilesimini bir formül (III) bilesimiyle tepkimeye sokmaktan meydana gelir, burada R halojen veya -O-SO2-X' tir, burada X alkil, alkenil veya istege bagli olarak alkille ikame edilmis aril veya aralkildir ve R1 dimetilaminodur, söz konusu tepkimeden sonra sitalopram baz veya bunun farmasötik açidan kabul edilebilir bir asit tuzu izole edilir ve eger R1 halojen veya -O-SO2-X grubu ise ki burada X yukarida tarif edildigi gibidir, tepkimeyi takiben elde edilen bilesim, burada R2 halojen veya -O-SO2-X grubu ise, burada X yukarida tarif edildigi gibidir, sitaloprama dönüstürülür ve sitalopram baz veya bunun farmasötik açidan kabul edilebilir bir asit tuzu izole edilir. (formül var)
Patent TR-200502284-T2 (TR)
Title: Kilo alımını tedavi ve/veya önleme metotları
Inventor: RICHARD DENIS
IPC: A61K31/453
Filed: 2000-07-05
Abstract: Insanlar da dahil olmak üzere hassas sicak kanli hayvanlarda asiri sismanlik, karin yagi ve ensülin direncinin tibbi tedavisi ve/veya önlenmesi için yeni metotlar selektif östrojen reseptör modülatörlerinin (SERM'ler) uygulanmasini gerektirir. Dehidroepiandrosteron, dehidroepiandrosteron sülfat, androst-5-en-3b,17b-diol ve önceki öncülerin ya da östrojenin herhangi birine in vivo olarak çevrilmis bilesiklerden olusan gruptan seçilmis bir cinsiyet steroid öncüsü ya da östrojenin bir miktari ile bir SERM'in bir kombinasyonu da ayni zamanda açiklanmaktadir.
Patent DE-602004005185-T2 (DE)
Inventor: MENTINK LEON
IPC: C09J103/02
Filed: 2004-05-28
Granted: 2007-11-08
Abstract: The invention relates to the use of a native or modified leguminous starch for producing an adhesive labeling composition. Said leguminous starch has an amylose content ranging between 25 and 60 percent by weight (dry/dry) and can be embodied as pea starch, especially pea starch having an amylose content of at least 30 percent but less than 50 percent by weight. The adhesive composition can advantageously be used for labeling glass or plastic bottles and can contain another natural polysaccharide polymer or protein polymer in addition to the leguminous starch, for example another native or modified leguminous or non-leguminous starch, particularly a starch having an amylopectin content of at least 80 percent by weight (dry/dry). The use of a leguminous starch makes it possible to obtain labeling adhesives, optionally highly dry (>40%) substances, which have excellent characteristics regarding stability during storage, rheology, and water resistance.
Patent DE-602004008273-T2 (DE)
Inventor: SEEGERT DIRK
IPC: A61K38/17
Filed: 2004-06-23
Granted: 2008-05-08
Abstract: A polypeptide dimer (I) comprises two soluble glycoprotein (gp) 130 molecules, where at least one of the gp130 molecules is covalently linked to polyethylene glycol (PEG). Independent claims are also included for: (1) a polynucleotide (II) encoding (I) or a monomer of (I); (2) an expression vector (III) containing (II); (3) a host cell (IV) containing (III); (4) producing (I); and (5) pharmaceutical composition (V) containing (I). ACTIVITY : Osteopathic; Cardiovascular-Gen.; CNS-Gen.; Gastrointestinal-Gen.; Immunomodulator; Cytostatic; Immunosuppressive; Antiinflammatory; Antibacterial; Virucide. MECHANISM OF ACTION : Calcium antagonist; Inhibitor of interleukin-6 (IL-6)/soluble IL-6 receptor (sIL6R) complex. Lamina propria mononuclear cells (LPMC) were cultured in complete medium consisting of RPMI-1640 with 3 mM L-glutamine, 10 mM HEPES buffer, 10 Microg/ml gentamycin, 100 U/ml penicillin, 100 U/ml streptomycin, 50 MicroM 2-mercaptoethanol and 10% heat-inactivated FCS. Cells were stimulated with 10 Microg/ml C reactive protein, 50 ng/ml phorbol-12-myristate-13-acetate (PMA) and 10 Microg/ml phytohaemagglutinin (PHA) in the presence or absence of sgp130Fc, neutralizing IL-6R specific antibody or sgp130PEG. After 48 hours cells were stained with Annexin V and propidium iodide and analyzed by fluorescence activated cell sorting (FACS). Unreacted samples contained approximately 60% apoptotic cells whereas treatment with anti-IL-6 antibody, sgp130Fc or sgp130PEG resulted in an increase of apoptotic cells between 11-16%. Similarly, the ability of sgp130PEG to inhibit IL-6/IL-6R dependent proliferation of BAF/3 cells and IL-6 induced signal transducer and activator of transcription (STAT3) activation in BAF/gp130 cells was studied. The results showed that the sgp130PEG treatment inhibited IL-6/IL-6R dependent proliferation of BAF/3 cells at a factor of 1.5-3 compared to sgp130Fc, and reduced the STAT3 activity with approximately 2-3 fold higher efficiency than sgp130Fc.
Patent DE-602004011383-T2 (DE)
Inventor: YAN YOUCHUN
IPC: A23D7/015
Filed: 2004-10-29
Granted: 2008-08-07
Abstract: A food product comprises a fat continuous emulsion, wherein the emulsion comprises a material comprising one or more organic compounds, said material being obtainable as an extract from pine needles.
Patent DE-602005003942-T2 (DE)
Inventor: GELLER BENOIT
IPC: H03M13/29
Filed: 2005-06-01
Granted: 2008-12-18
Abstract: A turbocode receiver system of a signal emitted by a turbo-coded modulated transmitter system, includes: a soft demapper ( 1 ) the output of which is connected to a turbodecoder ( 2 ), and an adaptive locked loop including: a measurement generator ( 3 ) the input of which is connected to the turbodecoder output to receive the reliability vector (LLR<SUB>out</SUB>) of the result and adapted to transform the vector into a reliability measurement (M(I)), equal to the average of the lowest reliability values of word bits, transmitted to a phase shift estimator ( 4 ) the output of which is connected to a phase compensator ( 5 ) positioned upstream of the soft demapper and adapted to correct the incoming signal of the phase value phi.
Patent DE-602005004872-T2 (DE)
Inventor: JONES BRIAN M
IPC: G06F11/07
Filed: 2005-11-29
Granted: 2009-02-19
Abstract: A method and computer-readable medium are provided for saving the contents of a memory structure stored in a volatile memory. According to the method, corrupted portions of the memory structure are identified and an attempt is made to repair these portions. If the corrupted portions cannot be repaired, the saving of these portions is skipped. The uncorrupted and repaired portions of the memory structure are then saved to a data file stored on a mass storage device. If portions of the memory structure cannot be repaired or skipped, an attempt is made to save only the user data contained in the memory structure to the data file. In this manner, the user data contained in the memory structure may be saved to a data file even in cases of severe corruption.
Patent DE-60104294-T3 (DE)
Inventor: HEDEN ANNA
IPC: B32B37/14
Filed: 2001-03-12
Granted: 2008-02-07
Abstract: A method of producing basic starting material for the manufacture of fastener tabs (31) intended for joining the side portions of the front and rear parts of an absorbent article that includes a front part, a rear part and an intermediate crotch part, so as to give the article a pants-like configuration. According to the invention the method comprises the steps of stretching a first sheet (1) of elastic material in a first direction (T); applying a second and a third sheet of material (9, 10) onto respective opposite sides of the first sheet; fastening the three material sheets together in at least two mutually separated zones (14, 15) that extend parallel with each other in one direction (M) perpendicular to said first direction; dividing the first sheet (1) in each region between two zones (14, 15) along a line that lies between said zones, wherewith the first sheet in each region (16) between two zones (14, 15) contracts to a non-stretched state, and thereafter fastening the sheets together in each regions (16) between two zones (14, 15). The invention also relates to an arrangement for carrying out the method, to starting material for producing fastener tabs, and to such a tab.
Patent DE-60222467-T3 (DE)
Inventor: OMORI KAZUHIRO
IPC: H01G9/052
Filed: 2002-12-10
Granted: 2017-12-07
Abstract: The present invention relates to a niobium alloy for capacitors comprising as an alloy component from 0.01 to 10 atom % of at least one element selected from the group consisting of the elements belonging to Groups 2 to 16 of the periodic table and further comprising diniobium mononitride crystals of from 0.1 to 70 mass %, wherein a powder of the niobium alloy has an average particle size of 0.05 to 5 μm and a BET specific surface area of 0.5 to 40 m2/g, a granulated product of the niobium alloy having an average particle size of 10 to 500 μm, a sintered body of the powder of the niobium alloy or granulated product thereof, a capacitor and a producing method thereof using the sintered body. A niobium capacitor using the powder of the niobium alloy of the present invention or a granulated product thereof has high capacitance and small leakage current value and is excellent in high-temperature property and heat resistance property.
Patent DK-1108796-T3 (DK)
Inventor: GIUNCHI GIOVANNI
IPC: C22C19/05
Filed: 2000-12-07
Granted: 2004-12-27
Abstract: A description follows of an article based on a nickel-chromium-silicon metal alloy, including microcrystalline borides, obtained by the rapid solidification and subsequent thermal treatment at a temperature from 700 DEG C to 950 DEG C for 5 minutes to 100 hours of a nickel-chromium-boron-silicon metal alloy comprising from 39.0 to 69.4 atom % of nickel, from 11.8 to 33.9 atom % of chromium, from 7.6 to 27.4 atom % of boron and from 7.6 to 17.5 atom % of silicon. The above article is preferably a tape or a sheet or a fiber having high mechanical properties and is particularly resistant to oxidation to be used as substrate for the growth of superconductor oxides or as a reinforcing element in composite materials with an organic, metallic or pyroceram matrix. <IMAGE>
Patent DK-1146924-T3 (DK)
Inventor: KIRCHHOFER FRITZ
IPC: A61M5/24
Filed: 2000-01-11
Granted: 2005-10-03
Abstract: The invention refers to a device for administering an injectable product in doses, comprising a casing, itself comprising: a reservoir for the product; a piston which forces product out of the reservoir when moved in a feed direction towards a reservoir outlet; a drive member; a driven member which is slaved by the drive member when the drive member is moved in the feed direction, so moving the piston in the feed direction; and a dosing member which may be rotated about the sliding axis of the drive member, to set the product dosage to be administered. The drive member and the dosing member abut each other via at least one dosage stopper each, one of which is provided on the drive member and the other on the dosing member. At least one of these dosage stoppers at least partially encircles the sliding axis of the drive member in the form of a spiral. The at least one spiral dosage stopper exhibits a continuous course with a constant pitch alpha.
Patent DK-1155138-T3 (DK)
Inventor: NAUGHTON ANDREW
IPC: C12P7/52
Filed: 2000-02-23
Granted: 2005-03-14
Abstract: The invention relates to a novel method for the preparation of optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives of the general formulae (I) and (II), in which R is ethyl or methyl and X is OH or NH2, provided that if R is methyl X<>  -OH. The method comprises the reaction of a racemic propionic acid amide of the general formula (III) either by means of microorganisms which are able to use the propionic acid amide in the form of the racemate or one of its optically active isomers as the only nitrogen source or by means of a polypeptide with amidohydrolase activity which is able to hydrolyze the propionic acid amide. The invention also relates to new optically active representatives of this category of compounds.
Patent DK-1131512-T3 (DK)
Inventor: STUBLER JEROME
IPC: E01D11/00
Filed: 2000-09-12
Granted: 2004-08-09
Abstract: An anchoring device for fixing a structural cable to a building element, the cable comprising a plurality of strands each comprising wires which are themselves enclosed together in a protective sheath, each of the protective sheaths being interrupted at a terminal edge such that the strands have each an exposed end section. The exposed section is inserted in a sealed chamber with a packing box whereof on plate is fixed and the other plate is compressed by threaded rods.
Patent DK-1275219-T3 (DK)
Inventor: DE MIER EDUARDO
IPC: H04L12/56
Filed: 2000-12-11
Granted: 2003-09-29
Abstract: A radio link with transmitters and a receiver transmits data packets of a data stream at a regular time interval. To receive the data packets, the data stream is sampled for the presence of data packets in a locked mode. In addition, times for an expected reception of one data packet each are predetermined. In a transmission mode, one data packet each is sampled at regular time intervals, it being determined from a comparison of a test coding with the content of the data packet whether an error-free data packet is present.
Patent DK-1247547-T3 (DK)
Inventor: KUO HAI PIN
IPC: A63B23/04
Filed: 2001-04-05
Granted: 2005-06-06
Abstract: The front ends of the levers (7,8) are pivotably secured to the bars (2,3) via pivot pins (73), while the rear ends are slidably engaged on tracks (41,42). The ends of the links (5,6) are respectively and rotatably secured to the cranks (14,15) and slides slidably received in the bars. An adjusting mechanism adjusts the slides relative to the bars to adjust the movement path of the foot supports (72,82). The cranks are rotatably secured to the rear section of a base (1) at a pivot shaft. The bars are pivotably secured to the upper section of a post (11). A pulley (23) is attached to the bottom end of each bar. The tracks are engaged and movably supported on the pulleys, such that the corresponding ends of the tracks are rotatably secured to the free ends of the cranks.
Patent DK-1212959-T3 (DK)
Inventor: HAFEMANN KLAUS
IPC: A45D20/12
Filed: 2001-11-29
Granted: 2005-02-07
Abstract: The switch assembly has an electric microswitch actuated by movable operating button. The switching assembly (3) of the hair drier (1) has a spring, and the operating button is movable against the spring force. A setting part is actuated by the operating button, for actuating the microswitch in an arrested position. The setting part forms an integral unit with the operating button. The spring is incorporated between the operating button and the setting part to exert a pressure in the direction of both elements.
Patent DK-1208000-T3 (DK)
Inventor: LEIGHTON MURRAY EDWARD BRUCE
IPC: B31B19/90
Filed: 2001-07-05
Granted: 2005-02-07
Abstract: A reclosable fastener (10) comprising a two-part body and a single flange (16) is located between two webs (34) of material from which a bag is to be made on a form-fill-seal machine. The fastener is attached initially to the inside of one web (34) by the flange (16). The combination passes between sealing jaws (44) to seal the webs to the fastener at thickened zones (30) at the margins of the body By making the body compact, and by using sealing jaws (44) which are longer than the body, the webs (34) form around the ends of the fastener body.
Patent DK-1305334-T3 (DK)
Inventor: VALE WYLIE W
IPC: A61P25/26
Filed: 2001-07-31
Granted: 2009-02-02
Abstract: A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
Patent DK-1265328-T3 (DK)
Inventor: EGGER CHRISTOPH
IPC: H01T13/39
Filed: 2002-05-15
Granted: 2004-07-12
Abstract: The device has an insulator body (1), at least one fixed earth electrode bearer arrangement and at least one fixed central electrode bearer. An ignition plug housing of at least two parts encloses the insulator body and has upper and lower parts (3,4). At least the insulator body part on the combustion chamber side is preferably completely enclosed by the lower housing part together with the upper housing part in a pressure tight manner. AN Independent claim is also included for a method of manufacturing an inventive device.
Patent DK-1363831-T3 (DK)
Inventor: LESAGE PHILIPPE
IPC: B62K25/28
Filed: 2002-03-01
Granted: 2008-03-25
Abstract: A vehicle rear suspension includes an underframe (1), a swing arm (15) integral with the underframe (1) bearing the axle of a drive wheel (19) hub and a shock-absorber (24), the torque drive being transmitted to the drive wheel (19) by chain (21) and pinion gears. The underframe (1) and/or the swing arm (15) comprises elements enabling the upper strand (22) of the transmission chain (21) or the straight line extending it, to pass through the instantaneous center of rotation C of the swing arm (15), when the vehicle is in position of static equilibrium, and enabling the upper strand (22) of the chain (21) to be located above the instantaneous center of rotation C when the hub of the drive wheel (19) is located above its position of static equilibrium.
Patent DK-1353754-T3 (DK)
Inventor: DOPPSTADT WERNER
IPC: B02C18/18
Filed: 2002-01-08
Granted: 2005-08-22
Abstract: The invention relates to a beating arrangement for a rotary shredder, comprising a base body (12) which is rotationally arranged around an axis (20) and a cutting body (16) which is detachably fixed onto a protruding part (22) of the base body. A protruding profile (50) is formed on the front surface thereof in the direction of rotation whereon the cutting body (16) forms a positive fit. The profile (50) can be embodied in the form of a protruding truncated pyramid, whose base surface lies on the plane of cutting edges (30, 32) which are bilaterally symmetrical in relation to a surface which extends tangentially in relation to a circumference of rotation. The cutting body can be fixed by means of a screw (14), which extends through the centre of the cutting body and the profile.
Patent DK-1397230-T3 (DK)
Inventor: CATALFAMO GIUSEPPE
IPC: B24D9/08
Filed: 2002-06-04
Granted: 2006-04-18
Abstract: Abrasive body (1) capable of being used in surface processing devices that has an active face (2a) provided with appropriate means of abrasion (3) intended to perform finishing operations on the surface of an object when the said body is set in motion. The abrasive body has a predetermined number of substantially passing cuts (6) defined by the respective flaps (7, 8) lying side by side. When the abrasive body is set in motion on an object to be processed, flaps (7, 8) deform in such a manner as to create appropriate opening that will permit the abraded dust particles to be removed solely and exclusively from that part of the abrasive body actually in contact with the object (FIG. 2).