Patent SG-11201906728T-A (SG)
Title: Multimeric oligonucleotides having decreased kidney clearance
Inventor: BROWN JONATHAN
IPC: A61K48/00
Filed: 2018-02-06
Abstract: HONH HO HO NH (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) W I PO I PCT o °nolo olommoollmoiliflo oimIE (10) International Publication Number WO 2018/145086 Al (51) International Patent Classification: A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61K 31/712 (2006.01) C07H 21/02 (2006.01) A61K 31/713 (2006.01) C07H 21/04 (2006.01) (21) International Application Number: PCT/US2018/017062 (22) International Filing Date: 06 February 2018 (06.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/455,231 06 February 2017 (06.02.2017) US 62/522,363 20 June 2017 (20.06.2017) US 62/561,853 22 September 2017 (22.09.2017) US (71) Applicant: MPEG LA, LLC [US/US]; 5425 Wisconsin Avenue, Suite 801, Chevy Chase, MD 20815 (US). (72) Inventors: NEUMAN, Kristin, K.H.; 10 Sackett Drive, Larchmont, NY 10538 (US). BROWN, Jonathan, Miles; Mpeg LA, LLC, 5425 Wisconsin Avenue, Suite 801, Chevy Chase, MD 20815 (US). VORNLOCHER, Hans-peter; Axolabs GmbH, Fritz-hornschuch-strar3e 9, D-95326 Kulm- bach (DE). (74) Agent: LINNIK, Konstantin et al.; Nutter McClennen & Fish LLP, Seaport West, 155 Seaport Boulevard, Boston, MA 02210-2604 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: MULTIMERIC OLIGONUCLEOTIDES HAVING DECREASED KIDNEY CLEARANCE W O 20 18/ 145 086 Al HO HO HO - NH O\ HO HO HO - NH O d \ FIG. 1A (57) : The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides. [Continued on next page] WO 2018/145086 Al MIDEDIMOMMIDIREI013010HEINIIMEIMMOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))