Patent SG-11201908136Q-A (SG)
Title: Continuous countercurrent spiral chromatography
Inventor: SHINKAZH OLEG
IPC: G01N30/42
Filed: 2018-03-28
Abstract: f 8 02 105 122 122 D>C 301 300 104 103 3 109 101 1-1 co co 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit °nolo HE mil mu mil ono oimIE (10) International Publication Number WO 2018/183483 Al (51) International Patent Classification: GO1N 30/42 (2006.01) BOlD 15/18 (2006.01) (21) International Application Number: PCT/US2018/024823 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/477,917 28 March 2017 (28.03.2017) US (71) Applicant: CHROMATAN INC. [US/US]; 200 Innova- tion Blvd., Suite 260B, State College, Pennsylvania 16803 (US). (72) Inventors: SHINKAZH, Oleg; 200 Innovation Blvd., Suite 260B, State College, Pennsylvania 16803 (US). FE- DORENKO, Dmitriy; 200 Innovation Blvd., Suite 260B, State College, Pennsylvania 16803 (US). (74) Agent: MARCUS, David M. et al.; 100 Pine Street, P.O. Box 1166, Harrisburg, Pennsylvania 17108-1166 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: CONTINUOUS COUNTERCURRENT SPIRAL CHROMATOGRAPHY FIG 4 (57) : A system, module and method for continuous countercurrent spiral chromatography are disclosed. The module includes an input port for receiving an input solution, a first mixer for mixing the input solution with a recycled solution to produce a first mixed output, a stage I separator for concentrating the first mixed output to produce a stage I solid fraction, a second mixer for mixing the stage I solid fraction from the stage I separator and an optional buffer solution to produce a second mixed output, and a stage II separator for concentrating the second mixed output to produce a stage II solid fraction which exits the module. At least one separator is a spiral separator. The system includes a plurality of modules, and at least one of the plurality of modules includes a spiral separator. The method includes purifying an unpurified solution with the plurality of modules. [Continued on next page] WO 2018/183483 Al MIDEDIMOMOIDEIREEMOMMENIVEMOVOIS GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))