Patent SG-11201809941V-A (SG)
Title: Compositions for treating liver cancer comprising a vascular disrupting agent
Inventor: KIM SOO JIN
IPC: A61K49/04
Filed: 2017-07-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111011111111101 IIIIIIIIII31101011110111111011111010101111111111111110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2018/021827 Al 01 February 2018 (01.02.2018) WIP0 I PCT (51) International Patent Classification: A61K 31/4196 (2006.01) A61K 49/00 (2006.01) (74) Agent: AHN, So Young; 4th Fl., 344, Seocho-daero, Seo- cho-gu, Seoul 06632 (KR). A61K 31/427 (2006.01) A61K 49/04 (2006.01) A61K 31/44 (2006.01) A61K 45/06 (2006.01) A61K 31/704 (2006.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/KR2017/008053 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 26 July 2017 (26.07.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 10-2016-0097347 29 July 2016 (29.07.2016) KR kind of regional protection available): ARIPO (BW, GH, (71) Applicant: CHONG KUN DANG PHARMACEUTI- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CAL CORP. [KR/KR]; 8, Chungjeong-ro, Seodaemun-gu, Seoul 03742 (KR). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors: KIM, Soo Jin; 315-20, Dongbaekjuk- jeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — = (KR). YU, Hosung; 315-20, Dongbaekjukjeon-daero, Gi- KM, ML, MR, NE, SN, TD, TG). heung-gu, Yongin-si, Gyeonggi-do 16995 (KR). KIM, Young Il; 301, 28-7, Saimdang-ro 19-gil, Seocho-gu, Seoul = 06638 (KR). — Title: COMPOSITIONS FOR TREATING LIVER CANCER COMPRISING A VASCULAR DISRUPTING AGENT = (54) [Fig. 1] (57) : The present disclosure provides compositions for treatment or adjuvant treatment of liver cancer, cam- = = .,0° a `, --- f 7 T prising (S)-N-(4-(3-(1H-1,2,4-triazol-1-y1)-4-(3,4,5-trimethoxy- 2 9 9 8 8 8 8 ° benzoyl)phenyl)thiazol-2-y1)-2-amino-3-meth lbutanamide or a Y pharmaceutically acceptable salt thereof. The compositions of the = = 1 411H IPP-79 . ai 1111Pral ,-. 4 k 4\" (4) a ifi j i l . lb present disclosure exhibit an excellent effect of treating liver can- cer. = a .1 10 .\" . 7 - Iraggi0 „—II = g\" 0 , iiiii All tai L i gg h = le. ,1 irr\" = _ = >. fg 0 — = 0 N 1 1.1 \" ' ' Ili f i A ha ' 1 6 41 0 1 a — 1-1 0 4 g po n y, ppm% r, ot 11 ei I N © ei .-, c It 0 2 I T. c a. ---.... E e E a o 8 La Il © ei C [Continued on next page] WO 2018/021827 Al MIDEDIMOMOIDEIREIEHEIHOEMOHMEHOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of