Patent SG-11201902941U-A (SG)
Title: Methods for reducing proteinuria in a human subject suffering from immunoglobulin a nephropathy
Inventor: BRUNSKILL NIGEL
IPC: A61K39/395
Filed: 2017-10-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WIP0 1 PCT °Ens °nolo mom tilos mom oimIE (10) International Publication Number WO 2018/071701 Al (51) International Patent Classification: A61K 31/7105 (2006.01) A61K 45/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) (21) International Application Number: PCT/US2017/056386 (22) International Filing Date: 12 October 2017 (12.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/407,979 13 October 2016 (13.10.2016) US 15/399,524 05 January 2017 (05.01.2017) US 15/470,647 27 March 2017 (27.03.2017) US 62/527,926 30 June 2017 (30.06.2017) US (71) Applicants: UNIVERSITY OF LEICESTER [GB/GB]; University Road, Leicester, Leicestershire LE1 7RH (GB). OMEROS CORPORATION [US/US]; 201 Elliott Av- enue West, Seattle, WA 98119 (US). (72) Inventors; and (71) Applicants: BRUNSKILL, Nigel, John [GB/GB]; 82 Main Street, South Croxton LE5 4PW (GB). DEMOPU- LOS, Gregory, A. [US/US]; 4845 Forret Avenue SE, Mer- cer Island, WA 98040 (US). DUDLER, Tom [CH/US]; 13410 NE 36th Street, Bellevue, WA 98005 (US). SCH- WAEBLE, Hans-Wilhelm [DE/GB]; 36 The Green, Mountsorrel LE12 7AF (GB). (74) Agent: QUINTON, Tineka; Omeros Corporation, 201 El- liott Avenue West, Seattle, WA 98119 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: METHODS FOR REDUCING PROTEINURIA IN A HUMAN SUBJECT SUFFERING FROM IMMUNOGLOBULIN = A NEPHROPATHY 1-1 1-1 O N 1-1 N O FIG 43 1 -1 (57) : In one aspect, the invention provides methods for reducing proteinuria in a human subject suffering, or at risk of 0 developing Immunoglobulin A Nephropathy (IgAN). The methods comprise the step of administering, to a subject in need thereof, an \" amount of a MASP-2 inhibitory antibody effective to inhibit MASP-2-dependent complement activation. [Continued on next page] C WO 2018/071701 Al MIDEDIMOMOIDEIREEMONOMMEREMEMOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1)) with sequence listing part of description (Rule 5.2(a))