baber/WOPTO huggingface dataset:
Patent SG-11201408054R-A (SG)
Title: Pegylated oxm variants
Inventor: FIMA UDI EYAL
IPC: A61K38/26
Filed: 2013-06-04
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/183052 A1 (51) International Patent Classification: A61K38/26 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IL2013/050481 4 June 2013 (04.06.2013) English English (30) Priority Data: 61/655,367 4 June 2012 (04.06.2012) US (71) Applicant: PROLOR BIOTECH INC. [IL/IL]; 7 Golda Meir Street, 2nd Floor, 74140 Nes Ziona (IL). (72) Inventors: FIMA, Udi Eyal; P.O.B. 238, 85330 Dvira (IL). HERSHKOVITZ, Oren; 10/17 Rupin Street, 75256 Rishon Lezion (IL). (74) Agent: PEARL COHEN ZEDEK LATZER; P.O. Box 12704, 4673339 Herzlia (IL). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: PEGYLATED OXM VARIANTS i-ys Lys OXM FMSl PEG30 I PEG30 N-terminus I PEG30 I Q-FMS Lys 30 seooocxxxo OXM N-terminus PEG30 Lys 12 Lys 30 PEG30 F M S FMS tm&mMMmm OXM Heterogeneous Product CJ © oo PEG30 FMS Lys 12 ry^vrY VrY YY^V^V^ : T T: r OXM N-terminus Homogeneous Product FIG. 1 i-H (57) Abstract: A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a revers - O ible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical ^ compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed. r*)
Patent HU-203753-B (HU)
Inventor: WEBER ABRAHAM
IPC: C07D401/04
Filed: 1987-10-08
Abstract: Verfahren zur Herstellung von 1-tertiaer-Alkyl-substituierten Naphthyridin- und Chinolin-Carbonsaeuren. Es werden neue Naphthyridin- und Chinolin-Carbonsaeuren und -carbonsaeurederivate mit einem 1-tertiaer-Alkyl-Substituenten sowie Verfahren zur ihrer Herstellung beschrieben und offenbart. Diese Verbindungen koennen insbesondere als Zwischenprodukte bei der Herstellung von Naphthyridin- und Chinolin-Carbonsaeuren, die zur Behandlung von bakteriellen Infektionen bei Warmbluetlern geeignet sind, verwendet werden.
Patent DK-151548-B (DK)
Inventor: BECKER WERNER
IPC: B65C11/02
Filed: 1982-03-04
Abstract: The present machine is intended for the printing of selected characters on labels borne by a continuous tape (13) passing over a print table (11) and driven by a chassis (22) imparted a reciprocating movement by the operating of a trigger. In order to prevent the strip of labels from being pulled towards the outside at the time of the pulling off of the label said machine has a hand brake (28, 30) located in front of the print table. This brake comprises a pivoting brake shoe (28) which is placed out of operation during the transport stroke of the continuous strip (13) by an interceptor (32) which is fastened to the transport chassis (22). This arrangement is established in order to permit a precise and effective braking action without requiring recourse to tolerances which are incompatible with mass production.
Patent HU-205857-B (HU)
Title: Process for producing liofilized products containing etoposide-2-dimethyl-amino derivative as active component
Inventor: OHTSUKI KAZUO
IPC: A61K47/26
Filed: 1991-01-18
Abstract: The present invention relates to a freeze-dried preparation comprising (1) about 5 to about 50 W/W% of a non-volatile acid and/or a salt thereof, (2) about 10 to about 95 W/W% of 4-O-(2-deoxy-2-dimethylamino-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-demethyl-4-epipodophyllotoxin hydrochloride and (3) 0 to about 85 W/W% of at least one sugar as a stabilizer.
Patent HU-197499-B (HU)
Inventor: VAJDA GABOR
IPC: A21D8/00
Filed: 1983-12-22
Abstract: A találmány burgonyapehely alapú állományjavító adalékanyag előállítására vonatkozik. A találmány lényege, hogy legfeljebb 5 tömeg% víztartalmú — 90-97 t% burgonyapehely és 3-10 tömeg% — antioxidánst tartal- mazó — zsiradék keverékét össztömegre számítva 80-120% vízzel állandó keverés mellett egyneműsitik és a masszát extrudálás után 120-150°C-on 5-25 percig szárítják majd őrlik. -1-
Patent LT-4716-B (LT)
Title: Method of producing concrete product
Inventor: BALANDIS ALFREDAS VLADAS
IPC: B28B1/08
Filed: 1998-10-19
Abstract: The invention concerns the construction industry. The aim of the invention is to widen technologic possibilities of concrete production. The lower part of the form (1) is filled with a first damp concrete mix layer (2) and the upper part (4) of the form is pressed through a hydraulic cylinder (3) operation. Vibration thickens the first layer (2). A void volume (A) appears between the surface of first layer (2) and the upper part of the form (4). The upper part (4) of the form is lifted and the void volume (A) is filled with the second damp concrete layer (5) through the operation of hydraulic cylinders. The second layer (5) is also pressed by the upper part of the form (4) and thickened by vibration through the operation of hydraulic cylinders (3).
Patent LT-4743-B (LT)
Title: Epothilone derivatives
Inventor: VITE GREGORY D
IPC: A61K31/335
Filed: 1999-12-23
Abstract: This invention concerns formula (I) compounds, where Q is selected from a group, consisting of (II), G is selected from the group, consisting of alkyl, alkyl with substitutes, aryl with or without substitutes, heterocycle, (III), W is O or NR15, X is O or H,H; Y is selected from a group consisting of O; H,OR16; OR17, OR17; NOR18; H,NOR19; H,NR20,R21; H,H; or CHR22; OR17 OR17 may be cyclic ketals, Z1 and Z2 are selected from the group, consisting of CH2, O, NR23, S pr SO2, where only Z1 and Z,2 can be a heteroatom; B1 and B2 are selected from a group, consisting of OR24 or OCOR25, or O2CNR25R27; when B1 is H and Y is OH, H, they can make a hexanomial ring ketal or acetal; D is selected from the group consisting of NR26R29, NR30COR31 or saturated heterocycle; R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R29 and R27 are selected from the group: H, alkyl with substitutes or aryl, when R1 and R2 are alkyl, they can be cohered and a cycloalkyl can form; R3 and R4 are alkyl, they can be cohered and a cycloalkyl can form; R9, R10, R16, R17, R24, R25 and R31 are selected from the group: H, alkyl or alkyl with substitutes; R8, R11, R12, R28, R30, R32, R33 and R30 are selected from a group, consisting of alkyl, alkyl with substitutes, aryl, aryl with substitutes, cycloalkyl, heterocycle; R15, R23 and R29 are selected from a group, consisting of H, alkyl, alkyl with substitutes, aryl, aryl with substitutes, cycloalkyl, heterocycle, R32C=O, R33SO2, hydroxyl, O-alkyl, O-alkyl with substitutes, their pharmaceutically acceptable salts, any hydrates, solvates or their geometrical, optical and stereo isomers except the compounds where: both W and X are O; R1, R2, R7 are H; R3, R4, R6 are methyl; both Z1 and Z2 are CH2; G us 1-methyl-2-(modified-4-tiasoli)ethylene; Q is as described above and is not included in the invention.
Patent YU-43401-B (YU)
Title: Process for obtaining of pyride-benzothiazine derivatives with anti bacterial activity
Inventor: MASCELLANI G
IPC: C07D513/06
Filed: 1985-02-25
Abstract: Pyridobenzothiazine derivatives with high antimicrobial activity having the following general formula: 
<CHEM>
 wherein
 R is H or CH3; n is 0 or 1 or 2 and Y is Cl or F, 
<CHEM>
 wherein R<1> is a C1-C6 alkyl
 or a C2-C6 alkenyl, or an arylalkyl, arylalkylcarbonyl, alkylcarbonyl, alkyloxycarbonyl, possibly substituted with halogens or hydroxy groups. 
<??>The present invention relates also to the processes for obtaining the compounds having the general formula (I). Such processes consist in synthesis routes using as starting products 3-chloro-4-fluoraniline, or 2,3,4-trifluoronitrobenzene.
Patent ZA-97105-B (ZA)
Title: Servo plunger mechanism
Inventor: LEIDY D WAYNE
IPC: C03B9/41
Filed: 1997-01-07
Abstract: A plunger mechanism for forming a hollow article of glass in a "narrow neck press and blow" operation which utilizes an electro servo-driven leadscrew to actuate it. A position sensing resolver is used to determine the position of the plunger over the full range of its stroke, and the position information can be used as feedback to control the position of the plunger prior to contacting a molten gob of glass in a mold chamber. The depth of the plunger penetration into the molten gob is then controlled by the pressing pressure, which is a function of motor torque and screw mechanics. It is possible to control the pressure exerted on the molten glass gob by controlling the torque applied by the motor. A separate gob weight controller is not required because changes in gob weight can be determined by closely monitoring the plunger penetration of the gob. <IMAGE>
Patent AT-390117-B (AT)
Title: Sleeve with head and thread
IPC: E05B15/16
Filed: 1988-06-30
Granted: 1990-03-26
Abstract: A sleeve 4, 4', 4", 4'" with head 9 and thread, which serves, in particular, for fastening a drilling-open guard plate 3 of furniture for locks, carries at least one approximately axially extending bore 7 which emanates from the head 5 and which is filled with a powder containing hard metal. This powder is fused or sintered in the bore 7 to form a core 9. Furthermore, in the head 5 a depression 8 is provided, which merges into the bore 7 and is likewize filled. The bore 7 may be widened at an increasing distance from the head 5. One or more cylindrical bores 7'", diverging relative to the mid-axis of the sleeve 4'", may also be provided. <IMAGE>
Patent AT-393408-B (AT)
Title: Attachment of the oil seal to a reciprocating piston internal combustion engine
Inventor: MUCKENHUBER MAXIMILIAN ING
IPC: F02F11/00
Filed: 1988-08-30
Granted: 1991-10-25
Abstract: The invention relates to the attachment of the oil seal 9 to a reciprocating piston internal combustion engine, which has an engine block 1 which comprises a cylinder block 2, cylinder head 3, piston 4, connecting rod 5, crank shaft 6 and its bearings 7. The engine block 1 is inserted in an outer trough 8 so as to provide insulation against structure-borne sound. The oil seal 9 is provided between the upper edge of the outer trough 8 and the engine block 1, encloses the latter like a frame, and has webs 10 which are pushed into grooves which on the one hand are provided on the outer trough 8 and on the other hand are associated with the engine block 1. In order to simplify the production of the groove on the side of the engine block 1, the groove is formed by a frame profile 12 composed of sheet metal or the like, which has a cross section that is open towards the outside of the frame and is roughly in the shape of a fork, with the fork handle 13 being gripped by and connected to the cylinder head seal 11. <IMAGE>
Patent CH-642222-B (CH)
Inventor: SHIGERU MOROKAWA
IPC: G04G5/04
Filed: 1979-07-05
Abstract: An electronic timepiece includes a primary timepiece circuit unit including a frequency supply for providing a relatively high frequency signal, a frequency converter responsive to the relatively high frequency signal to provide a relatively low frequency time unit signal, timing signals, and a plurality of word pulses indicative of a plurality of data words representing time data concerning the current time, and a set of additional data other than the time data, a timekeeping register arranged to store the time data and the additional data, and display elements for displaying the time data and the additional data. A secondary timepiece circuit unit includes a register arranged to store the additional data to be transferred to the timekeeping register.
Patent DK-142121-B (DK)
Inventor: SITTMANN B
IPC: E05D11/00
Filed: 1971-03-18
Abstract: The sealing device invisible from the outside, lies between wing frame (21) and fixed frame (20) on swinging or turning windows or doors has axially offset sealing surfaces between the frames on both sides of the axis, and sealing strips extending over these surfaces and over the bearing joints. - Each of the sealing strips (27) consists of two sealing bars (28, 29) set between the two frames and on the same frame, sealing the axially offset sealing surfaces which are in a plane parallel to the axis (1) between the axially overlapping frame pieces. They are mutually offset like the sealing surfaces. These are combined with a cross member (30) joining the sealing bars together to form a Z-shaped sealing strip.
Patent DK-151295-B (DK)
Title: Method of producing a decorative pattern on the surface of a soft plastic material and apparatus for use in performing the method
Inventor: NIELSEN JENS PETER
IPC: B44C/
Filed: 1985-05-08
Abstract: A sloping roof structure comprises a supporting structure (72) and a plurality of elastically flexible, outwardly convexly curved roofing plates (74) mounted thereon. The roofing plates are mounted in a partly overlapping relationship so that the lower rim portion of each plate overlaps the upper rim portion of an adjacent lower plate. Each roofing plate is fastened to the supporting structure by means of nails (75), screws or other fastening means at a portion intermediate of the upper and lower rim portions of the plate. The initially curved plate is fixed in an at least partly flattened condition, whereby the upper and lower rim portions are resiliently pressed against the supporting structure (72) and the outer surface of the adjacent lower plate, respectively. The curved roofing plates (74) for such a roof structure may be made from a layer (37) of a plastic, deformable material, such as a cement mixture which may be reinforced by fibers. This layer of material may be placed on a curved supporting surface (70) so that the layer of material attains a shape similar to that of the supporting surface. The layer of material may then be hardened or set while supported by the curved supporting surface.
Patent DK-158081-B (DK)
Title: Hull
Inventor: GUETTLER JO
IPC: B63B/
Filed: 1986-10-03
Abstract: A body for a sailing boat, at the stern end of which are located devices (14a, 17a) for separating the water from the hull (1), whereby a continuous hydrodynamic transformation of a positive-displacement body into a sliding body is possible, even during movement.
Patent FI-78489-B (FI)
Inventor: COUSIN MICHEL
IPC: C08G14/06
Filed: 1984-12-27
Granted: 1989-04-28
Abstract: In a process for hardening phenol-formaldehyde resol resins, comprising conducting the hardening of the resins with an acidic solution of water and/or an organic solvent having dissolved therein an aromatic sulphonic acid and/or concentrated sulphuric acid, the improvement comprising the hardening in the presence of aniline added to the phenolic resin beforehand in a quantity of between about 0.5 and 2% relative to the weight of the phenolic resin whereby the pot life is extended and the cure time is satisfactory, the resultant products being especially useful as prepegs.
Patent FI-80743-B (FI)
Inventor: FREDENUCCI PIERRE
IPC: D21H17/28
Filed: 1986-01-17
Granted: 1990-03-30
Abstract: The invention relates to a treatment process for improving the dimensional stability of a fibrous sheet obtained by papermaking process, and of which at least part of the fibers are cellulosic fibers, said process consisting in impregnating the sheet with a chemical composition containing at least one wetting agent and one binder.
Patent FI-87578-B (FI)
Inventor: HELLSTROEM INGEGERD
IPC: G01N33/532
Filed: 1986-05-27
Granted: 1992-10-15
Abstract: The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas («NSCLC») and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in the lung of a subject. The method involves examining tissue from the subject for the presence of antigens which are Le<sup>x</sup> or Le<sup>Y</sup> antigen or which have the characteristics of Le<sup>Y</sup> and Le<sup>x</sup>.
Patent FI-86333-B (FI)
Inventor: ELONEN JORMA
IPC: F04D29/24
Filed: 1988-04-11
Granted: 1992-04-30
Abstract: The present invention relates to a method and apparatus for separating gas by a pump from the medium being pumped, which method and apparatus are especially suitable in pumping the gaseous fiber supensions in the wood processing industry. In known apparatus, it has been difficult to prevent solids from entering the gas discharge system fur guiding the gas out of the pump so that the system would clog and give rise to the necessity for expensive and time-consuming reparation. The method and apparatus in accordance with the present invention eliminates or minimizes the above disadvantages in that rear vanes (11) of the pump or the members operating together with them are arranged in such a way that they either direct the flow of the medium, generated by the combined effect of forces with different directions and different intensities directed at the medium in the space behind the impeller in the vane gaps of said rear vanes, past a gas discharge opening (12) in the rear wall of the pump, or they dampen the flow so that its extension to said gas discharge opening (12) is prevented.
Patent FI-86158-B (FI)
Inventor: LEHTINEN REIJO
IPC: B29C48/90
Filed: 1989-09-22
Granted: 1992-04-15
Abstract: A sizing tool for extruding plastic tubing is disclosed. The tool includes a peripheral wall having an inner surface that defines the outer dimension of a plastic tubing advancing from an extruder through the tool under influence of an internal pressure exceeding the pressure prevailing in the tool. The tool also includes a lubricating water channel system in the peripheral wall and extending along the tool length and having at least one opening communicating with the inner surface of said peripheral wall. The tool also includes a cooling medium channel system in the peripheral wall and extending along the length. The cooling medium channel system being substantially closed within the peripheral wall and being separate from the lubricating water channel system.
Patent FI-96857-B (FI)
Inventor: MATSUO MASAAKI
IPC: C07D277/42
Filed: 1990-08-06
Granted: 1996-05-31
Abstract: A compound of the formula : <CHEM>  wherein  R<1> is hydrogen or acyl which may be substituted with halogen, R<2> is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy,  A is -CH2-, -CO-, -C(=NOR<4>)- [wherein R<4> is lower alkyl, <CHEM>  [wherein m is 0, 1 or 2], and R<3> is aryl which may be substituted with halogen, hydroxy, lower alkoxy, nitro, amino or acylamino; or N-containing unsaturated heterocyclic group which may be substituted with lower alkyl, amino, hydroxy or halo(lower)alkyl,  and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with pharmaceutically acceptable carriers.
Patent FI-115724-B (FI)
Inventor: MOTTE PHILIPPE
IPC: C08G18/65
Filed: 1995-09-26
Granted: 2005-06-30
Abstract: A polyol blend for use in production of a high resilience foam is described. The blend comprises: a reactive polymer polyol of the kind used in high resilience polyurethane foam; a polyol of the kind used in conventional polyurethane foam; and a diol as a chain extender. A composition of the polyol blend and a silicone surfactant may be reacted with a modified toluene diisocyanate to produce a high resilience polyurethane foam.
Patent HU-189857-B (HU)
Inventor: SCHMIDT ATTILA
IPC: G01D4/10
Filed: 1984-04-05
Abstract: A találmány tárgya programozható maximumérték figyelő készülék, célszerűen teljesítménydíjas szerződés alapján vételező fogyasztási helyek egyidejű hatás teljesítményfelvételének időlntervallumos átlagteljesítmény mérésén alapuló szabályozására, amely áz áramszolgáltató fogyasztásmérőjéből érkező im- Ítubusokat fogadó számlálóval, a mérési időintervalumokon belüli részidő mérésére alkalmas időalapot előállító áramkörrel, egy kiértékelő egységgel, valamint egy, a kiértékelő egység kimenetére kötött kapcscdó és/vagy jelző elemeket magába foglaló beavatkozó szervvel rendelkezik. A találmány szerinti készülék lényege, hogy a kiértékelő egység egy mérési időintervallum végére megadott maximális érték elérésekor kapcsolójelet szolgáltató végkapcsolóból (16) és legalább egy - a mérési időintervallumokon belül, a mérési időpontokhoz tartozó, az eltelt idővel arányos értékek elérésekor kapcsolójelet szolgáltató - részkapcsolóból (15) van felépítve. A részkapcsoló(k)nak (15) és a végkapcsolónak (16) egymással párhuzamosan kapcsolt, a számláló (13) kimenetére kötött bemenetel (23) valamint a számlálóimpulzusokkal összehasonlításra kerülő értékek beállítására alkalmas programozható bemenetel (29, 30) továbbá a részkapcsoló(k)nak (15) az időalap áramkör (14) kimenetét (26) fogadó, egymással párhuzamosan kötött bemenete(i) (24)és az időintervallumon belüli mérésidő beállítására alkalmas programozható bemeneteQ) (31) és a fogyasztók részleges vagy teljes lekapcsolását vég^ő beavatkozószervet vezérlő kimenetei (17) vannak. Az időalap áramkör (14) a számláló (13) és a kiértékelő egység törlő bemenete az áramszolgáltató fogyasztásmérőjéből érkező, a mérési időintervallumok végit jelző jelet adó törlő jelfogóra (11) van kötve.  -1-
Patent HU-190534-B (HU)
Title: Improved process for preparing l-beta-phenyl-alanine and acid addition salts tereof
Inventor: GRESSAY JOZSEF
Filed: 1984-04-11
Abstract: L-beta-phenyl-alanine is prepd. by salt formation in aq. soln. from 1 mole equiv. N-acetyl-DL-beta-phenyl -alanine with 0.5-0.65 mole equivs. D-(+)-threo-2-amino -3-(4'-nitrophenyl) -propane-1,3-diol in the presence of 0.45-0.55 mole equivs. inorganic base, separating the resulting salt, liberating the N-acetyl-L-beta-phenyl -alanine by treatment with mineral acid and desacetylating it, opt. separating the resulting L-beta-phenyl-alanine in the form of its acid addition salt and opt. liberating the amino-acid from its acid addition salt. - The N-acetyl-D-beta -phenyl-alanine remaining in the mother liquor is opt. racemised, pref. without sepn., by treatment with acetic anhydride in the presence of alkali-metal-hydroxide, the resulting N-acetyl-DL-beta phenyl-alanine is returned to the process. Finally the mother liquor remaining after liberation of N-acetyl-L-beta -phenyl-alanine is opt. made alkaline to regenerate D-(+)-threo-2-amino-3-(4' nitrophenyl) propane-1,3-diol which is returned to the process.