Patent SG-11201900133W-A (SG)
Title: Adrenomedullin for assessing congestion in a subject with acute heart failure
Inventor: BERGMANN ANDREAS
IPC: G01N33/74
Filed: 2017-07-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 01111111111 11111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/007588 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: G01N 33/68 (2006.01) G01N 33/74 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — with sequence listing part of description (Rule 5.2(a)) PCT/EP2017/067091 (22) International Filing Date: 07 July 2017 (07.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16178725.4 08 July 2016 (08.07.2016) EP 16199092.4 16 November 2016 (16.11.2016) EP (71) Applicant: SPHINGOTEC GMBH [DE/DE]; Neuendorf- str. 15 A, 16761 Hennigsdorf (DE). (72) Inventors: BERGMANN, Andreas; Am Rosenanger 78, 13465 Berlin (DE). VOORS, Adriaan; Scheperij 5, 9312VH Nietap (NL). (74) Agent: BOEHMERT & BOEHMERT; Dr. Ute Kilger, Hollerallee 32, 28209 Bremen (DE). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) ,_ 1 (54) Title: ADRENOMEDULLIN FOR ASSESSING CONGESTION IN A SUBJECT WITH ACUTE HEART FAILURE (57) : Subject matter of the present invention is a method for a) diagnosing congestion or assessing or monitoring the extent GO of congestion in a subject or, b) predicting or determining or monitoring need of therapy or intervention or predicting or determining = or ir) monitoring the success of a therapy or intervention of congestion or guiding a therapy or intervention in a subject or, c) predicting N decongestion or residual congestion after therapy or intervention of congestion in a subject or, d) assessing decongestion or residual 0 congestion after therapy or intervention of congestion in a subject or, e) assessing the decision on hospital discharge of a subject, wherein 0 --.... said subject is subject having acute heart failure that is either new-onset AHF or acute decompensated HF or acute decompensated Ot chronic HF or wherein said subject is a subject having chronic heart failure with worsening signs/symptoms of chronic heart failure 1-1 O and wherein Pro-Adrenomedullin or fragments thereof of at least 5 amino acids is used as an early surrogate marker for congestion. ei C