baber/WOPTO huggingface dataset:
Patent CA-2417873-A1 (CA)
Inventor: CHRETIEN MICHEL
IPC: C07K14/47
Filed: 2001-08-01
Abstract: A novel Asp-ase activity, referred to as BACE secretase/sheddase, has been found to cleave the ectoddomain of BACE after Asp379 (SQDD.dwnarw.) and Asp407 (VVFD.dwnarw.), and likely after Asp451 (PQTD.dwnarw.). The cleavage of BACE  by BACE secretase/sheddase renders BACE soluble which in turns appears to enhance the generation of the amyloidogenic peptide A.beta., which has been implicated as a major factor in the etiology of Alzheimer's Disease. The current invention concerns the modulation of this novel BACE  secretase/sheddase activity for such applications as the prevention or treatment of a neurodegenerative disorder that is characterized by the generation of A.beta. protein, including Alzheimer's Disease. The invention further comprises a method for the identification of an agent that can alter the ability of BACE secretase/sheddase to associate with and process a known substrate, a method of determining whether an individual is at risk of developing a neurodegenerative disorder that is characterized by the generation of A.beta. protein (such as Alzheimer's Disease) and a kit comprising a vessel or vessels containing BACE secretase/sheddase as well as at least one known substrate of this enzyme, namely, BACE or BACE fragments, or the indirect substrate .beta.APP.
Patent CA-2418736-A1 (CA)
Title: Use of epoxypolysiloxanes modified with oxyalkylene ether groups as additives for radiation-curing coatings
Inventor: SILBER STEFAN
IPC: C08F283/12
Filed: 2003-02-11
Abstract: The use of epoxypolysiloxanes which are modified with oxyalkylene ether groups and contain, attached to an Si atom of the epoxypolysiloxane, at least one group of the general formula (I) -R3-O-(C n H(2n-m)R4m O-)x R5 (I) in which R3 is a divalent, unsubstituted or substituted alkyl or alkylene radical having 2 to 11 carbon atoms, n is 2 to 8, m is 0 to 2n, x has a value of 1 to 200, and R4 stands for identical or different alkyl radicals having 1 to 20 carbon atoms or for identical or different, unsubstituted or substituted phenyl radicals having up to 20 carbon atoms, R5 is a hydrogen radical, an unsubstituted or substituted alkyl radical having 1 to 0 carbon atoms, an acyl radical or a radical -O-CO-NH-R6, in which R6 is an unsubstituted or substituted alkyl or aryl radical, it being possible for the oxyalkylene segments -(C n H(2n-m)R4m O-) within one oxyalkylene ether radical to be different from one another and for the sequence of the individual oxyalkylene segments -(C n H(2n-m)R4m O-) to be arbitrary, embracing in particular block copolymers, random polymers, and combinations thereof, as additives to cationically radiation-curing coatings, printing inks and/or print varnishes.
Patent CA-2419681-A1 (CA)
Inventor: PATEL ANILBHAI S
IPC: A61L27/34
Filed: 2001-08-24
Abstract: The application of switchable tackiness coating compositions to ophthalmic implants provides the benefits of body temperature tackiness without the disadvantages of room temperature tackiness.
Patent CA-2419807-A1 (CA)
Title: Complexing structure, device and method for treating liquid effluents
Inventor: LEDERF FRANCK
IPC: B01J47/12
Filed: 2001-08-29
Abstract: The present invention relates to a complexing structure, to a method for treating liquid effluent using said complexing structure, and to a device for implementing the method of the invention. The structure comprises a film of a polymer or of an electrically neutral organic copolymer. In addition, the present invention relates to a system and method for treating an effluent using said structure.
Patent CA-2420591-A1 (CA)
Inventor: BEASLEY ELLEN M
IPC: C12Q1/48
Filed: 2001-08-24
Abstract: La présente invention concerne des séquences d'acides aminés de peptides qui sont codés par des gènes à l'intérieur du génome humain, les peptides kinases décrits dans cette invention. Plus particulièrement, cette invention concerne des molécules peptidiques et des molécules d'acides nucléiques, des méthodes permettant d'identifier les peptides kinases orthologues et paralogues, et des méthodes permettant d'identifier les modulateurs des peptides kinases.
Patent CA-2422620-A1 (CA)
Inventor: SAKAMOTO TOMOAKI
IPC: C07K16/40
Filed: 2003-03-19
Abstract: A method of producing a modified monocotyledonous plant having a desired character is provided. The method comprises isolating a gene containing a nucleic acid hybridizable to a nucleic acid indicated by SEQ ID NO. 1 under stringent conditions, and inhibiting, expression of the isolated gene.
Patent CA-2423068-A1 (CA)
Inventor: FOOTE JAMES K
IPC: G01N37/00
Filed: 2001-09-25
Abstract: La présente invention concerne un procédé et un dispositif d'éjection acoustique de gouttelettes de liquide de plusieurs réservoirs contenant un liquide. Les gouttelettes sont éjectées sur des sites de la surface d'un substrat pour y être déposées. Le dispositif comprend plusieurs réservoirs, chacun adapté pour contenir un liquide; un éjecteur comprenant une unité servant à générer un rayonnement acoustique et une unité servant à focaliser le rayonnement acoustique généré de manière à éjecter des gouttelettes de liquide des réservoirs; et une unité de positionnement de l'éjecteur en relation de couplage acoustique à chaque réservoir. L'invention peut être utilisée dans un grand nombre de contextes, en particulier dans la préparation de réseaux biomoléculaires tels que les réseaux peptidiques et les réseaux oligonucléotidiques.
Patent CA-2424206-A1 (CA)
Inventor: ROUNTHWAITE ROBERT L
IPC: G06Q10/10
Filed: 2003-03-31
Abstract: A system and method facilitating detection of unsolicited e-mail message(s) with challenges is provided. The invention includes an e-mail component and a challenge component. The system can receive e-mail message(s) and associated probabilities that the e-mail message(s) are spam. Based, at least in part, upon the associated probability, the system can send a challenge to a sender of an e-mail message. The challenge can be an embedded code, computational challenge, human challenge and/or micropayment request. Based, at least in part, upon a response to the challenge (or lack of response), the challenge component can modify the associated probability and/or delete the e-mail message.
Patent CA-2424555-A1 (CA)
Title: Triptolide analogs for the treatment of autoimmune and inflammatory disorders
Inventor: VENKATESAN HARIHARAN
IPC: A61K45/00
Filed: 2001-10-02
Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone e.g.  Formula (I) or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds. (I)
Patent CA-2424574-A1 (CA)
Title: Laser a cavite externe accordable
Inventor: KAPANY NARINDER S
IPC: H01S5/14
Filed: 2001-09-27
Abstract: La présente invention concerne un système de laser accordable (10) comprenant une diode laser (15) en cavité externe se combinant à un guide d'ondes (20) à couplage optique dans lequel est formé un réseau de Bragg (25). La diode laser (15) vient constituer un milieu de gain caractérisé par une première bande de longueurs d'ondes. Le réseau (25) et une partie de la fibre (20) concourent à définir une cavité résonante externe. Le réseau (25) contient les longueurs d'ondes excitant la cavité externe dans les limites d'une seconde bande bien plus étroite que le première. La zone de réseau du guide d'ondes est thermiquement couplée à un élément chauffant (30) auquel est associé un régulateur thermique (32) régulant la température de la zone de réseau (25) de façon à modifier le pas optique du réseau (25) et par voie de conséquence la seconde bande. La zone de réseau du guide d'ondes (20) peut, d'une autre façon ou en plus, être soumise à une énergie acoustique (45) faisant varier le pas optique du réseau (25).
Patent CA-2429504-A1 (CA)
Inventor: HEJL PETR
IPC: G06Q50/34
Filed: 2003-05-26
Abstract: At present, the group message is defined to be set of to be sent or sent messages. This model has several disadvantages, as it is not possible to receive, store and evaluate the messages.      In the invention, not only to be sent or sent messages but also received messages can form a group message. And moreover, a group message can include not only simple messages, but also group messages.     The most important suggestion is, that one of the parameters, defining the group message structure, is the type of group message. There are mentioned 16 types of group messages, e.g. simple message, answer message, contest, betting, voting, chat or auction; also other types can be created based on the invention.      The said method enables to realize one general model of group message, to define the group message in unified way using common and special data and to run the group messaging using messaging engines.
Patent CA-2429540-A1 (CA)
Title: Method for controlling an electric treadmill
Inventor: WANG LEAO
IPC: A63B22/02
Filed: 2003-05-22
Abstract: The present invention relates to a method for controlling an electric treadmill which includes emission type sensor sets (e.g. infrared, etc.) arranged at two proper places of the treadmill and connected to the control console, thereby creating air sensing fields covering a specific range. Therefore, the operator can give any intentional signal that is detectable by the sensor during the walking exercise session. Thereafter, the sensor orders the control console to perform a control action to the controlled motor on receipt of the intentional signal of the operator.
Patent CA-2431675-A1 (CA)
Title: Novel sulfamides and their use as endothelin receptor antagonists
Inventor: FISCHLI WALTER
IPC: C07D409/14
Filed: 2001-12-04
Abstract: The invention relates to novel sulfamides of general formula (I) and their u se as active ingredients in the preparation of pharmaceutical compositions. The  invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
Patent CA-2433235-A1 (CA)
Inventor: EFTHIMIADIS ANN
IPC: B01L99/00
Filed: 2003-06-25
Abstract: There is provided an apparatus and method for collection and filtration of a sample having a sample holder, a filtrate holder and a connection conduit having a sample receiving end and a filtrate receiving end and containing a filter. The sample holder has an entry end portion and an exit end portion, with a diaphragm normally closing the exit end portion. The filtrate holder has a closeable receiving end portion for receiving the filtered sample. The connection conduit has a rupturing device for rupturing the diaphragm on exit end portion of the sample holder. When the sample holder is inserted into the connection conduit, the diaphragm rupturing device ruptures the diaphragm, allowing the sample be filtered by the filter located within the connection conduit and the filtrate is collected in the filtrate holder.  Also described is a method of collecting a biological sample, and filtering the sample, and holding the filtrate in a filtrate holder.
Patent CA-2434599-A1 (CA)
Inventor: ROGRIGUES JOSE
IPC: B05B12/14
Filed: 2002-01-17
Abstract: A color shade changing unit module for a painting installation is provided including a generally parallelepiped-shaped part, a bore formed in the part, a central channel into which the bore converges, the channel being perpendicular to end faces of the module, a valve housed in the bore, the valve including a closing element, a chamber formed in the part, a paint feed channel and a paint return channel leading into the chamber and leading out onto a side face of the module generally opposite from a wall in which the bore is formed, the closing element of the valve being designed, depending on a position of the closing element, to isolate, or to connect the central channel and the paint feed and paint return channels, and also including external pipes, connectors which connect the paint feed and paint return channels to the external pipes, each such connector having an externally threaded first, smaller-diameter part designed to screw into the external pipe, and a second, larger-diameter part surrounded by at least one seal and designed to fit leaktightly into a well formed in the module, the bottom of which leads into the respective paint feed and paint return channels.
Patent CA-2435411-A1 (CA)
Title: Method of inducing angiogenesis by micro-organs
Inventor: MITRANI EDUARDO
IPC: A61K35/12
Filed: 2000-06-22
Abstract: A method of inducing angiogenesis in a tissue of a mammal is provided, the method including the step of implanting at least one micro-organ within the tissue of the mammal, the at least one micro-organ being for producing a plurality of angiogenic factors and thereby inducing angiogenesis.
Patent CA-2435742-A1 (CA)
Title: Herbicidal composition
Inventor: TORRENT MARLENE
IPC: A01N25/30
Filed: 2002-02-25
Abstract: A herbicidal composition in the form of an aqueous emulsion which comprises, as organic phase, a solution of a herbicidally effective amount of the compound 2-(4-(3-chloro-5-fluoro-2-pyridyloxy)-phenoxy-propionic acid propargyl ester in a hydrophobic solvent and a substantially water-insoluble and hydrolysis-stable oil phase stabiliser and, as aqueous phase, a solution of a pH buffer and at least one surface-active compound and/or dispersing agent in water.
Patent CA-2436525-A1 (CA)
Title: Method and program product for producing and using game play records in a bingo-type game
Inventor: ENZMINGER JOSEPH R
IPC: G07F17/32
Filed: 2002-01-30
Abstract: A gaming system (10) utilizes a game designation generating component (16), a gaming establishment component (11), and a set of predefined bingo card representations. Each bingo card representation is stored in electronic format as a data structure or data record defining a predefined pattern of game designations chosen from a pool of available designations. The game designation generating component (16) generates sets of game designations from a pool of available designations. The method employed in the gaming system (10) includes pre-matching the bingo card representations to a given set of game designations to produce a matched card set. This pre-matching occurs prior to the sale, distribution, or assignment of card representations to players in the game.
Patent CA-2438438-A1 (CA)
Inventor: TAKEI TAKASHI
IPC: A61K9/14
Filed: 2003-08-22
Abstract: The present invention relates to controlled release granules for medical use comprising a drug loaded porous silica particle, and at least one layer of a controlled release coating material, characterized in that the drug loaded porous silica core is prepared by immersing dry porous silica particles with a solution, suspension or emulsion comprising at least one pharmacologically active drug and the resulting wet drug loaded porous silica core is subsequently dried again. Furthermore, the invention concerns a method for preparing the controlled release composition.
Patent CA-2439455-A1 (CA)
Inventor: YODA TOSHIAKI
IPC: B01J49/00
Filed: 2002-02-26
Abstract: A method for regenerating an adsorbent having adsorbed a persistent substanc e, characterized in that the persistent substance is contacted with a microbe and/or an enzyme in the interior or at the periphery of pores of the adsorbe nt to thereby decompose the substance. The method allows an adsorbent having adsorbed a persistent substance, such as bis-phenols, harmful to living thin gs to be completely decomposed and removed and thus allows the adsorbent to be regenerated, without adverse effect on the environment by secondary pollutio n.
Patent CA-2441333-A1 (CA)
Title: Game for a gaming device where a player competes with a computer
Inventor: GAUSELMANN MICHAEL
IPC: G07F17/32
Filed: 2003-09-17
Abstract: In one embodiment of the invention, a game involves the player playing against a gaming machine's computer such that a victory by the player in the game grants an award to the player. In one particular game, the player and computer compete to build a structure created from objects. The player and computer alternate turns. The player chooses from a number of icons, each representing a hidden object, with the hope of choosing the tallest object, and the computer randomly selects an object. The player attempts to build a structure above a winning height before the computer's structure reaches the winning height. Along the way, the player is given various options, such as the option to change positions with the computer, the option to buy an object, or other types of options. In another embodiment, instead of the player playing against the computer, if the gaming machine is connected to a network with other gaming machines, multiple players may play against each other, and the player with the best result wins a special award.
Patent CA-2444565-A1 (CA)
Title: Improved additive for livestock feeds
Inventor: SOLA JOSE
IPC: A23K1/18
Filed: 2002-04-23
Abstract: Improved particulate feed additives and methods are provided for enhancing feed utilization efficiency in a ruminant animal by adding to the feed of th e animals a particulate feed additive comprising a nonionic surfactant to enhance the utilization of the feed by the animal and a sufficient amount of an antioxidant agent to substantially enhance the shelf life of the feed additive. The methods and compositions result in enhanced weight gain and/or milk production by the animal.
Patent CA-2445314-A1 (CA)
Inventor: TAKEMASA HIROAKI
IPC: A61P43/00
Filed: 2002-04-25
Abstract: Recurrence-free survival time-extending agents for patients with lung squamous carcinoma at the pathologic histological stage I which contain aminopeptidase inhibitors such as ubenimex as the active ingredient; or survival time-extending agents, in particular, recurrence-free survival time-extending agents for patients with the same disease at the pathologic histological stage IB after lung cancer removal.
Patent CA-2445976-A1 (CA)
Inventor: POPE RANDY D
IPC: A47J31/44
Filed: 2002-04-30
Abstract: An improved method and apparatus for brewing a brewing substance. The apparatus including a liquid conduit (18) for supplying a brewing liquid, a liquid permeable container (28) for retaining the brewing substance and allowing the brewed liquid to pass through, a spray member (20) for delivering the brewing liquid from the liquid conduit to a brewing substance and discharging the brewing liquid into the liquid permeable container, a liquid flow modifier (52) for varying the flow rate of liquid at the spray member, and a control member (44) operably connected to the liquid flow modifying member for causing the liquid flow modifying member to vary the liquid flow rate. The alteration of the discharge of the liquid from at least a first spray pattern to at least a second spray pattern facilitating mixing of the brewing liquid and brewing substance within the liquid permeable container.
Patent CA-2450730-A1 (CA)
Title: Methods for sterilizing preparations of monoclonal immunoglobulins
Inventor: DROHAN WILLIAM N
IPC: A61L2/00
Filed: 2002-06-13
Abstract: Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such a viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.
Patent CA-2451202-A1 (CA)
Title: Pocket lamp
Inventor: RAUSSECK PETER
IPC: F21V5/00
Filed: 2002-05-24
Abstract: A pocket lamp consisting of a base body (10) and a lamp head (12) with at least two luminous diodes (32a, 32b), each of which having an optical device (44a) associated with one of said luminous diodes (32a, 32b) (44a), said optical device being used to focus the light radiated by the respective luminous diode, and respectively one tube body (56a, 56b, 56c) disposed between one of the luminous diodes (32a,32b) and the associated optical device (44a) for focussing the light radiated by the respective luminous diode. The tubes (56a, 56b, 56c) are embodied in such a way that substantially prevent light from one of the luminous diodes from penetrating into (32a, 32b) an optical device for focussing the light radiated by the respective luminous diode associated with one of the other luminous diodes (32a,32b).
Patent CA-2451665-A1 (CA)
Title: Implant having improved fixation to a body lumen and method for implanting the same
Inventor: DICARLO PAUL
IPC: A61F2/06
Filed: 2002-06-26
Abstract: A device for improving fixation and sealing of a prosthetic component when implanted in a body lumen during laparoscopic, endovascular, or open surgical procedures. In one embodiment, the prosthetic component comprises a graft having a hem defining an interior space. Enclosed within the space is an absorbent cord. The cord expands as it comes in contact with body fluids. The expansion due to the absorbed fluids forms a seal closely following the irregular shape of the lumen and improves fixation at the junction of the body lumen and the prosthetic component. Hem and cord arrangement also used to improve fixation of one prosthetic component to another in a modular graft. In another embodiment, an attachment tab has one part affixed to the outer periphery of the graft and another part attached to an area adjacent to the body lumen upon implantation, to resist forces tending to move the implant.
Patent CA-2453071-A1 (CA)
Title: Genes and proteins for the production of polyene polyketides
Inventor: FARNET CHRIS M
IPC: C07C235/28
Filed: 2004-01-21
Abstract: This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells.     The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
Patent CA-2454642-A1 (CA)
Title: Self-illuminating fabricated solid material objects
Inventor: SEELY DANIEL
IPC: E01C17/00
Filed: 2003-12-31
Abstract: Self-illuminating fabricated solids: pavers, driveway stones, building blocks, or statuary, having optical fibers positioned within a receptacle with one end of the fibers visually terminating at predetermined positions on the object's surface. Furthermore, the receptacle is adapted to reversibly receive, or alternatively to be operatively related to, a reversibly powered light source to provide for light that travels from the source through the fibers to the surface of the fabricated object providing for self-illuminating seasonal designs, informational text, or advertising. A plurality of designs in various colors may exist on a single object. These durable objects are long lasting as surface exposed fibers wear with the surface of the object and worn-out light sources are easily and rapidly replaced. For extensive displays, a fiber optic cable may be utilized to transmit light from a single or a plurality of remote light sources to one or a plurality of fabricated solid objects.