Patent TW-200403245-A (TW)
Title: Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
Inventor: SALVATI MARK E
IPC: C07D487/04
Filed: 2003-03-28
Abstract: Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders. A compound of formula I, wherein R1 is selected from the group consisting of H, hydroxyl, alkyl, aralkyl, halogen, OR1', OC(O)R1', OC(O)OR1', OCCONR1'R1", OS(O)2R1', and OS(O)2NR1'R1", wherein R1' and R1" is each independently H, alkyl, aryl, aralkyl, heterocyclo, or cycloalkyl; or may be taken together to form a cycloalkylaryl or heterocylic group, any of which may be optionally substituted; R2 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, heterocycle, aralkyl, carbalkoxy, acyl, carboxamido, amine, or substituted amine, wherein each of said carbalkoxy, acyl, and carboxamido groups is optionally substituted with one or two substituent groups, each of which is independently H, alkyl, alkoxy, cycloalkyl, aralkyl, or heterocycle; R1 and R2 when taken together may form a cycloalkyl, aryl, or heterocyclic group, any of which may be optionally substituted; X is selected from the group consisting of a valence bond, O, NR2', and S(O)n, wherein n is 0, 1, or 2, and wherein R2' is H, alkyl, aralkyl, C(O)R1, C(O)OR1, SO2NR1'R1", C(O)NR1'R1", OR SO2R1; R3 is selected from the group consisting of H, hydroxyl, alkyl, cycloalkyl, a heterocycle, aryl, aralkyl, acyl, carbalkoxy, carboxamido, halogen, amine, substituted amine, OR3', CH2OR3', CH2NR3'R3", CH2SR3', OC(O)R3', OC(O)OR3", OC(O)NR3'R3", OS(O)2R3', and OS(O)2NR3'R3", wherein R3' and R3" is independently H, alkyl, aralkyl, heterocycle, cycloalkyl, or aryl, wherein R3' and R3" when taken together may form a cycloalkyl, aryl, or heterocyclic group, any of which may be optionally substituted, wherein each of said carbalkoxy, acyl, and carboxamido groups is optionally substituted with one or two substituent groups, wherein the substituent groups when taken together may form a cycloalkyl, aryl, or heterocyclic group, any of which may be optionally substituted, and R2 and R3 when taken together may form a cycloalkyl, aryl, or heterocyclic group, any of which may be optionally substituted; R4 is selected from the group consisting of H, alkyl, cycloalkyl, a heterocycle, aryl, aralkyl, carbalkoxy, acyl, and carboxamido wherein each of said carbalkoxy, acyl, and carboxamido groups is optionally substituted with one or two substituent groups, each of which is independently H, alkyl, alkoxy, aralkyl, or a heterocycle; Y is selected from the group consisting of a valence bond, O, NR4', and S(O)m, wherein m is 0, 1, or 2, and wherein R4' is H, alkyl, aralkyl, or a heterocycle; R5 is selected from the group consisting of H, halogen, cyano, alkyl, cycloalkyl, a heterocycle, aryl, aralkyl, acyl, carbalkoxy, carboxamido, OS(O)2R5', and OS(O)2NR5R5", wherein each of said carbalkoxy, acyl, and carboxamido groups is optionally substituted with one or two substituent groups, each of which is independently H, alkyl, aralkyl, or a heterocycle, and wherein R5' and R5" is each independently H, alkyl, aryl, aralkyl, heterocycio, or cycloalkyl; and Z is selected from the group consisting of a valence bond, alkylene group, 0, NR5"', and S(O)p, wherein pis O, 1, or 2, and R6 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, aralkyl, a heterocycle, acyl, carbalkoxy, and carboxamido, wherein each of said carbalkoxy, acyl, and carboxamido groups is optionally substituted with one or two substituent groups, each of which is independently H, alkyl, aralkyl, or a heterocycle; and the salts, solvates, and stereoisomers thereof.