Patent SG-11201803949R-A (SG)
Title: Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine
Inventor: POZUELO RUBIO MERCEDES
IPC: A61P35/00
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau (43) International Publication Date ..... .....r .,„0 26 May 2017(26.05.2017) WIPO I PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111311111111111111111 2017/085228 Publication Al Number (51) International Patent Classification: (74) Agent: ILLESCAS TABOADA, Manuel; C/ Principe de A61K 9/08 (2006.01) A61K 47/26 (2006.01) Vergara, 197, Oficina 1° A, 28002 Madrid (ES). A61K 9/19 (2006.01) A61P 35/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2016/078078 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 17 November 2016 (17.11.2016) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 15194864.3 17 November 2015 (17.11.2015) EP TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: BIONCOTECH THERAPEUTICS, S.L [ES/ES]; Parque Cientifico de la Universidad de Valencia, (84) Designated States (unless otherwise indicated, for every C/ Catedratico Agustin Escardino 9, Paterna, 46980 Valen- kind of regional protection available): ARIPO (BW, GH, cia (ES). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: POZUELO RUBIO, Mercedes; Bioncotech TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Therapeutics, S.L, Parque Cientifico de la Universidad de DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Valencia, C/ Catedratico Agustin Escardino 9, Paterna, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 46980 Valencia (ES). QUINTERO ORTIZ, Marisol; SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Bioncotech Therapeutics, S.L, Parque Cientifico de la Uni- GW, KM, ML, MR, NE, SN, TD, TG). versidad de Valencia, C/ Catedratico Agustin Escardino 9, Published: Paterna, 46980 Valencia (ES) VILLANUEVA GARCIA, Ana; Plaza Xuquer 8-8, 46021 Valencia (ES). — with international search report (Art 21(3)) Il .4t Ge ei ei in of:, (54) Title: NOVEL PHARMACEUTICAL COMPOSITION COMPRISING PARTICLES COMPRISING A COMPLEX OF A O DOUBLE-STRANDED POLYRIBONUCLEOTIDE AND A POLYALKYLENEIMINE IN (57) : The present invention relates to compositions comprising particles, each of said particles comprising a complex of at 1-1 O least one double-stranded polyribonucleotide, such as polyinosinic-polycytidylic acid [poly(I:C)], and at least one linear polyal - el kyleneimine. The particles are also characterized by their monomodal diameter distribution and z-average diameter within specific O ranges. The present invention additionally relates to use of said compositions as medicaments, in particular for the treatment of a cell ,1 . growth disorder characterized by abnoiinal growth of human or animal cells, as well as to processes for the preparation of said com - .,- positions.