Patent SG-11201408453P-A (SG)
Title: Methods for determining personalized treatment compositions for prostate cancer and breast cancer
Inventor: WATSON JAMES DOUGLAS
IPC: C12N5/09
Filed: 2013-07-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/007661 A1 (51) International Patent Classification: G01N 33/574 (2006.01) CI2N 5/09 (2010.01) C12N 5/0783 (2010.01) A61K38/16 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/NZ2013/000115 3 July 2013 (03.07.2013) English English (30) Priority Data: 61/668,395 5 July 2012 (05.07.2012) US (71) Applicant: CALDERA HEALTH LTD. [NZ/NZ]; PO Box 11664, Ellerslie, Auckland 1542 (NZ). (72) Inventors: WATSON, James, Douglas; 18 Eltham Road, Apartment 3, Kohimarama, Auckland 1071 (NZ). FOR- STER, Richard, Llewellyn, Sydney; 263 Ostrich Road, Patumahoe, Pukekohe 2679 (NZ). (74) Agent: IN-LEGAL LIMITED; PO Box 8026, The Ter­ race, Wellington 6143 (NZ). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: METHODS FOR DETERMINING PERSONALIZED TREATMENT COMPOSITIONS FOR PROSTATE CANCER AND BREAST CANCER l> o o FIGURE 7A 50 45 40 35 30 25 20 15 10 5 0 t ; TimeO 3 wks jHealthy^ealthy TimeO Week 3; •TimeO 3wks TimeO Week3 CaP CaP iHeaithyNealthy CaP CaP CD8+T ceils CD4+T cells o CJ o & (57) Abstract: The present disclosure provides methods for selecting treatment a composition, or therapy, for the treatment of a can­ cer, such as prostate or breast cancer, in a patient wherein the treatment composition includes administering combination of a at least two components selected from immune cell activating agents, such as GM-CSF, and antigen display enhancing agents, such as keto - conazole. Methods for treating a patient using the selected treatment composition are also provided, together with methods for mon­ itoring the efficacy of the treatment composition during a treatment period.