baber/WOPTO huggingface dataset:
Patent AT-E249907-T1 (AT)
Inventor: BILLEROT FRANCIS
IPC: B23K9/127
Filed: 1999-11-12
Granted: 2003-10-15
Abstract: The installation also has (a) a first longilinear and electrically conducting connection means (17) connected by its upstream end (17) to the means of piloting (3) and by a downstream end (17') to the capactive probe (2, 4); and (b) a second longilinear and electrically conducting connection means (18) connected by its upstream end (18) to the means of piloting (3) and of which the downstream end (18') is free. A cutting and welding installation comprises a fixed support fitted with a mobile working torch (1) and a feeling device (2, 3, 4) incorporating a capactive probe (2, 4) and some means for piloting. An Independent claim is included for a method used in the installation for maintaining the distance between the torch (1) and the workpiece (5) essentially constant.
Patent AT-E210255-T1 (AT)
Inventor: SORENSEN JENS JORREN
IPC: B66F19/00
Filed: 1999-03-25
Granted: 2001-12-15
Abstract: An elongate spindle member having rigidity and stability against pressure and tensile loads as well as bending and torsional loads is made by winding-up a plurality of mutually interlocking chain links ( 1, 12 ), during axial advancement of the chain links, into a helical winding ( 5, 16 ) by a winding guide ( 14 ). The elongate spindle member, formed by the helical winding, extends between two objects, one of which is connected with the winding guide ( 14 ). The first turn of the helical winding is connected with a coupling member for connection with the other of the two objects. The helical winding is formed by drivingly connecting the chain links to a rotatable driving device in the winding guide and retaining each chain link in engagement with neighboring links in the same turn as well as adjacent chain links in neighboring turns.
Patent AT-E316316-T1 (AT)
Inventor: KNUDSON EDWARD B
IPC: G06F13/00
Filed: 1999-04-22
Granted: 2006-02-15
Abstract: A banner advertisement containing text graphics or video is provided adjacent to program listing displayed on program guide screen. The user is allowed to scroll the listings by positioning a highlight on the banner advertisement and cursor is activated. The advertisements containing video, is provided to user television equipment, by a video server. Several network nodes are used to provide television program to user television equipment. When user selects the banner advertisement, he is provided with an opportunity to tune the given channel. An independent claim is also included for implementation method of interactive television program guide method.
Patent AT-E256570-T1 (AT)
Inventor: FREDERIKSEN SVEND
IPC: B60H1/32
Filed: 1999-06-22
Granted: 2004-01-15
Abstract: A system for providing cooling incorporates a combustion engine (1, 2) equipped with an exhaust heat recovering heat exchanger (3) which is adapted to transfer heat energy to a heat-driven chiller (4) in which cooling can be extracted from one or more heat carrier circuits (8). The cooling thereby provided may be used for cooling of engine charge air or compressor air and/or for providing cooled air for human comfort and/or for goods. Use of heat energy derived from the engine exhaust gas flow can be added to the system. Exhaust or air intake heat exchangers may provide silencing or gas cleaning of air or gas. The system may, e.g., be applied to vehicles. Compact absorption chillers may be used in the system. A method for providing cooling is disclosed.
Patent AT-E258398-T1 (AT)
Inventor: PATEL MANHAR K
IPC: A45D40/00
Filed: 1999-07-13
Granted: 2004-02-15
Abstract: A dispenser includes a holder/carrier for products of stick-like form to enable application of a wide variety of materials. A plurality of resilient/flexible barbs having spring-like properties extend into the holder/carrier for embedding into the received material. The barbs preclude dislodgment of the stick-like product which may occur due to vibration caused during shipment or subsequent use of the dispenser.
Patent AT-E222268-T1 (AT)
Inventor: BIERMANN CHRISTIAN
IPC: C08L75/04
Filed: 1999-06-18
Granted: 2002-08-15
Abstract: The invention relates to a process for the production of charged polyurethanes comprising reacting isocyanate groups of a polyisocyanate with hydroxyl groups of alcohols comprising (i) a first alcohol selected from one or more diols containing at least 10 carbons atoms; (ii) a second alcohol selected from alkylene diols having not more than 8 carbon atoms, alkyleneoxy diols having not more than 8 carbon atoms, polyols, and mixtures thereof; (iii) a third alcohol selected from (a) diols containing a charged group or atom, (b) diols containing an uncharged group or atom capable of charge formation and at least partially converting the uncharged group or atom into a charged group or atom, (c) polyols and further reaction of one or more hydroxyl group derived from the polyol with a compound containing a charged group or atom or a compound containing an uncharged group or atom capable of charge formation and at least partially converting said uncharged group or atom into a charged group or atom, and mixtures thereof. The invention further relates to charged polyurethane obtainable by the process, an aqueous dispersion thereof and the use thereof in a method of surface-treating a material in sheet or web form by applying the charged polyurethane to the surface of the material.
Patent AT-E415005-T1 (AT)
Inventor: SAIRANEN MARTTI
IPC: G05F1/44
Filed: 1999-07-30
Granted: 2008-12-15
Abstract: The invention relates to an arrangement for eliminating radio interference in an electronic power regulator. The regulator comprises a switching unit (1) and a control unit (2), said switching unit (1) including two semiconductor switching units (5, 6) coupled in parallel, the first being a transistor switching unit (5) and the second a tyristor switching unit (6); said switching unit (1) is coupled in series with the load (3), and the power regulator regulates the AC current fed in the load, so that by means of the control unit (2), during the half-cycle of the supply voltage, at a point of time (t), the transistor switching unit (5) is first switched to conductive state, and immediately thereafter the tyristor switching unit (6) is also switched to conductive state, and both switching units (5, 6) are switched to cut-off state at the next zero point of the half-cycle. According to the invention, the arrangement comprises a coil (9) with a low inductance, or a corresponding inductor, which is arranged in series with the tyristor switching unit (6), so that the tyristor switching unit (6) and the coil (9) are in parallel with the transistor switching unit (5).
Patent AT-E388234-T1 (AT)
Inventor: KODALI DHARMA
IPC: C10M101/04
Filed: 1999-08-03
Granted: 2008-03-15
Abstract: Plants, seeds and oils having a total long chain monounsaturated content of at least about 82% and an erucic acid content of at least about 15% are described. Methods for producing plants having the profiled fatty acid content are also described.
Patent AT-E293254-T1 (AT)
Inventor: MARONEY ANNA
IPC: G01N33/50
Filed: 1999-08-18
Granted: 2005-04-15
Abstract: Methods for identifying compounds which modulate activity of a multiple lineage kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple lineage kinase protein with the compound, determining whether the compound decreases activity of the multiple lineage kinase protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple lineage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo- compound of the invention are also provided. Methods of treating neurodegenerative disorders and/or inflammation are also provided.
Patent AT-E236958-T1 (AT)
Inventor: SKARBARDONIS JOHN G
IPC: C08J5/00
Filed: 1999-09-07
Granted: 2003-04-15
Abstract: There is described herein a thermoplastic article which has a high transmittance, less than about 95% haze and low clarity. If this article is placed in front of an object, the observer on the far side of the article will see the object, but not clearly.
Patent DE-501183-T1 (DE)
IPC: E01B31/17
Filed: 1992-02-04
Abstract: It comprises a rigid frame (10), connected to the chassis of a railway vehicle by lifting means for the light running of the vehicle and at least one polishing unit (11, 12). Each polishing unit (11, 12) is installed on a support (13) in such a way that it may be displaced linearly in order to move the wheel (11) towards or away from the surface of the rail (1, 2) to be polished. The axis of the wheel (11) is located in a plane perpendicular to the longitudinal axis of the rail (1, 2) but does not intersect the latter, so that the line of contact between the wheel (11) and the surface of the rail (1, 2) is contained within a plane perpendicular to the longitudinal axis of the rail. The support (13) is installed on the frame (10) with translation means (16) enabling it to be displaced transversely in relation to the frame (10). The support (13) comprises at least one bearing roller (17) and bearing means (18), connecting this support (13) to the frame (10) and tending to press this bearing roller (17) against one of the flanks of the rail (1, 2) in the immediate vicinity of the polishing unit (11, 12). 
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Patent DE-925137-T1 (DE)
Inventor: SATRAN AMIR
IPC: B23C5/20
Filed: 1997-07-28
Abstract: A chip cutting insert has an upper chip surface, a lower base surface, at least three side surfaces and at least two cutting edges formed at the intersection of the upper surface with two insert side surfaces. Each cutting edge has leading and trailing ends. The side surface associated with each cutting edge comprises an upper primary relief section inclined to the insert base surface at a first interior angle, and a lower secondary relief section inclined to the insert base surface at a second interior angle, the second interior angle being acute and being different from the first interior angle at least along a part of the cutting edge.
Patent ES-2250022-T1 (ES)
Title: Metodo y aparato para alineacion ocular.
Inventor: YOUSSEFI GERHARD
IPC: A61B3/113
Filed: 2004-02-18
Abstract: En un sistema de cirugía ocular por láser que incluye un aparato láser para generar un haz láser terapéutico que tiene un eje del haz terapéutico y un rastreador del ojo que tiene un eje de alineación para controlar los movimientos del ojo, operando dicho rastreador del ojo en acoplamiento cooperativo con dicho aparato láser, una mejora caracterizada por un aparato en acoplamiento cooperativo con dicho sistema de cirugía ocular por láser adaptado para emitir un haz de exploración que tiene un eje óptico co-alineado y concéntrico con el eje del haz terapéutico y adaptado para emitir una señal tras la detección por dicho aparato de una primera reflexión Purkinje del haz de exploración y una segunda reflexión Purkinje del haz de exploración si dichas primera y segunda reflexiones Purkinje están co-alineadas y concéntricas, en el que dicha señal se usa para disparar la operación del rastreador del ojo.
Patent ES-2430256-T1 (ES)
Title: Penetrador y método para su fabricación
Inventor: ROSE DAVID M
IPC: F42B33/00
Filed: 2011-09-21
Abstract: Un método de fabricación de un penetrador que tiene una geometría de cabeza de flecha y una geometría debase, comprendiendo el método: recalcar en frío un trozo de material para formar una pieza en bruto; mecanizar la pieza en bruto para crear la geometría de cabeza de flecha; y conformar por laminación la pieza en bruto para crear la geometría de base.
Patent ES-2029966-T1 (ES)
Title: Acumulador de plomo/acido sulfurico, separador para acumuladores de plomo/acido sulfurico y procedimiento para bloquear la formacion de residuos tenidos en un acumulador de plomo/acido sulfurico.
IPC: H01M50/417
Filed: 1990-08-23
Abstract: SE DESCRIBE UNA INVENCION POR MEDIO DE LA CUAL SE CONSIGUE REDUCIR EN CUANTO A LA CANTIDAD LAS SEDIMENTACIONES DE COLOR, LA MAYORIA DE LAS VECES OSCURAS Y CON FRECUENCIA PEGAJOSAS QUE SE FORMAN EN ACUMULADORES DE PLOMO CON SEPARADORES DE POLIOLEFINAS RELLENAS DURANTE LA FORMACION Y EL FUNCIONAMIENTO. LA CARACTERISTICA ESENCIAL CONSISTE EN QUE LOS SEPARADORES CONTIENEN COMO PLASTIFICANTE UN ACEITE DE PROCESO CON UN VALORDE (MENOR O IGUAL) 6 %, UN CONTENIDO DE AZUFRE DE (MENOR O IGUAL) 2000 PPM Y UNA PORCION POLAR DE (MENOR O IGUAL) 1 %. LOS ACEITES DE PROCESO PREFERIDOS UTILIZADOS COMO PLASTIFICANTES SON ACEITES RELATIVAMENTE NAFTENSICOS Y NAFTENICOS.
Patent ES-2042428-T1 (ES)
Inventor: HARDIE GREGORY J
IPC: C22B1/10
Filed: 1992-09-10
Abstract: A method for treating gases and solids in a fluid bed, the fluid bed reactor substantially comprising, regarded downstream, a mixing chamber (14), a riser pipe (9) and a cyclone (16) with a solids return pipe (11) to the mixing chamber (14), the gases being introduced into the mixing chamber (14) at a gas rate immediately before the inlet port (4) of the mixing chamber of more than (35) m/sec. <IMAGE>
Patent ES-2107985-T1 (ES)
Inventor: SCHNEIDER GUNTER
IPC: C04B28/08
Filed: 1996-06-10
Abstract: In an excavation structure consisting of a slit wall (2) of a hardened single phase slit wall material, with a surface exposed at the excavation side, and spaced-apart vertical support elements (5) inserted in the slit wall material, the slit wall (2) forms a compartment (6) between the support elements (5) and the slit wall material includes a water-retaining light aggregate. Also claimed are (i) a method of producing the above excavation structure; and (ii) a building material mix for use in the method.
Patent ES-2123480-T1 (ES)
Title: Cojinetes de refuerzo para el recentrado positivo de los cojinetes magneticos.
Inventor: MILLER ROBIN M
IPC: F16F15/18
Filed: 1996-12-16
Abstract: LOS SISTEMAS DE ORIENTACION, TAL COMO ORIENTACION POR EL RUMBO MAGNETICO, SE UTILIZAN ACTUALMENTE EN UNA GRAN VARIEDAD DE APLICACIONES. SIN EMBARGO, TODOS LOS SISTEMAS DE ORIENTACION ESTAN EXPUESTOS A FALLOS. POR LO TANTO, A MENUDO SE UTILIZAN SISTEMAS DE ORIENTACION DE RESPALDO CONJUNTAMENTE CON EL SISTEMA DE ORIENTACION PRINCIPAL A FIN DE TENER UN SUSTITUTO PARA LAS ORIENTACIONES PRINCIPALES, EN CASO DE QUE ESTAS FALLEN. EL SISTEMA DE ORIENTACION DE RESPALDO PARA REAJUSTAR EL CENTRADO DE LOS RUMBOS MAGNETICOS INCLUYE UN PRIMER MIEMBRO CONICO DISPUESTO ALREDEDOR DE UN EJE Y QUE TIENE, AL MENOS, UN RUMBO BASICO DISPUESTO EN SU INTERIOR; UN SEGUNDO MIEMBRO CONICO SEPARADO DEL PRIMER MIEMBRO CONICO Y DISPUESTO ALREDEDOR DEL EJE, CUYO SEGUNDO MIEMBRO TIENE, AL MENOS, OTRO RUMBO DISPUESTO EN EL; Y UN CONJUNTO IMPULSOR SEPARADO DEL SEGUNDO RUMBO Y MIEMBRO CONICO, EN UNA POSICION PRIMERA U OPERATIVA. EL CONJUNTO IMPULSOR ACTUA PARA MOVER EL SEGUNDO MIEMBRO CONICO Y LOS RUMBOS DISPUESTOS EN EL ENTRE LA PRIMERA POSICION OPERATIVA, EN LA QUE EL SISTEMA DE ORIENTACION DE RESPALDO FUNCIONA PARA REAJUSTAR EL CENTRADO DEL RUMBO MAGNETICO A UNA SEGUNDA POSICION, NO OPERATIVA, CUANDO LOS RUMBOS MAGNETICOS ESTAN OPERANDO DE NUEVO.
Patent CY-1106888-T1 (CY)
Inventor: KLEIN PETER
IPC: C07D295/088
Filed: 2007-09-26
Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.
Patent CY-1110364-T1 (CY)
Inventor: PIRONE WALTER
IPC: G07C9/00
Filed: 2008-06-09
Abstract: A magnetic lock device operated by means of transponder is provided with at least an electromagnet mean (2) connected to a fixed portion (3) of a door (4) and with at least a keeper mean (5) fixed to the door (4) and, in a closing condition of this latter, facing the electromagnet mean (2). The device (1) includes: a control mean (6) for switching the electric supply of the electromagnet mean (2); a sensing mean (9) in data connection with the control mean (6) and fit to sense the proximity of a plurality of mobile transponders (10) each one associate to a respective operator. The control mean (6) is fit to interrupt the electric supply to the electromagnet mean (2) when the sensing means (9) senses the proximity of at least a transponder (10) and vice versa.
Patent CY-1108149-T1 (CY)
Title: Αβερμεκτινες και μονοσακχαριτες αβερμεκτινων υποκατασταθεντες στη θεση 4΄ και 4΄΄ εχοντες παρασιτοκτονο δραση
Inventor: MURPHY KESSABI FIONA
IPC: A01N43/90
Filed: 2008-06-18
Abstract: Περιγράφεται μία ένωση τύπου (I) στον οποίο ο δεσμός μεταξύ των ατόμων άνθρακα 22 και 23 είναι ένας απλός ή διπλός δεσμός· το m είναι 0 ή 1 το R1 είναι αλκύλιο με C1-C12, κυκλοαλκύλιο με C3-C8 ή αλκενύλιο με C2-C12· και είτε (Α) το R2 είναι -N(R3)R4 και (1) το Χ είναι O, όπου το R3 είναι, για παράδειγμα, υδρογόνο, μη υποκατασταθέν ή μονο- έως πεντάκις υποκατασταθέν αλκύλιο με C1-C12, και το R4 είναι, για παράδειγμα, μονο- έως πεντάκις υποκατασταθέν αλκύλιο με C1-C12, ή μονο- έως πεντάκις υποκατασταθέν κυκλοαλκύλιο με C3-C12· ή (2) το Χ είναι S, όπου το R3 είναι, για παράδειγμα, υδρογόνο, μη υποκατασταθέν ή μονο- έως πεντάκις υποκατασταθέν αλκύλιο με C1-C12, και το R4 είναι, για παράδειγμα, υδρογόνο, μονο- έως πεντάκις υποκατασταθέν αλκύλιο με C1-C12, ή (3) το Χ είναι O ή S, όπου τα R3 και R4 ομού είναι, για παράδειγμα, μία γέφυρα αλκυλενίου με τρία έως επτά μέλη ή αλκενυλενίου με τέσσερα έως επτά μέλη· ή (Β) το R2 είναι OR5, το Χ είναι Ο ή S, όπου το R5 είναι, για παράδειγμα, αλκύλιο με C1-C12, μονο- έως πεντάκις υποκατασταθέν αλκύλιο με C1-C12· ή, αν εφαρμόζεται, ένα ισομερές Ε/Ζ, ένα μίγμα ισομερών Ε/Ζ και/ή ένα ταυτομερές της, σε κάθε περίπτωση σε ελεύθερη μορφή ή σε μορφή άλατος· αυτή η ένωση εμφανίζει παρασιτοκτόνο δράση.
Patent CY-1110614-T1 (CY)
Inventor: VANZIN DAVID ALAN
IPC: C07D279/20
Filed: 2010-03-22
Abstract: Solid product comprising a phenothiazine material in the form of generally spherical prills is new.
Patent CY-1113153-T1 (CY)
Inventor: MASAT LINDA
IPC: C07K16/24
Filed: 2012-09-28
Abstract: An IL-1² binding antibody or IL-1² binding fragment thereof comprising a light chain variable region comprising the amino acid sequence of SEQ ID NO: 11 and a heavy chain region comprising the amino acid sequence of SEQ ID NO:15, and related nucleic acids, vectors, cells, and compositions.
Patent CY-1114285-T1 (CY)
Title: Μεθοδοι για την παρασκευη 3-ο-αποακυλιωμενου-4’-μονοφωσφορυλο λιπιδιου α (3d-mla)
Inventor: MYERS KENT R
IPC: C12N1/20
Filed: 2013-07-02
Abstract: Στο παρόν αποκαλύπτεται μια μέθοδος για παρασκευή λιποπολυσακχαριδίου (LPS), που περιλαμβάνει: (α) ανάπτυξη καλλιέργειας ενός πολύ ακατέργαστου μεταλλακτικού βακτηριακού στελέχους σε ένα μέσο, (β) διατήρηση της καλλιέργειας σε στατική φάση για τουλάχιστον 5 ώρες, (γ) συλλογή κυττάρων από την καλλιέργεια και (δ) εξαγωγή LPS από τα κύτταρα. Η μέθοδος επιτρέπει την παρασκευή ενός LPS που μπορεί να χρησιμοποιηθεί για να παράγεται 3-Ο-αποακυλιωμένο μονοφωσφορύλο λιπίδιο Α (3D-ΜLΑ) που έχει τουλάχιστον περίπου 20 mol% της εξαακύλ συγγενούς ομάδας. Επίσης στο παρόν αποκαλύπτεται μέθοδος εξαγωγής λιποπολυσακχαριδίου (LPS) από μια καλλιέργεια πολύ ακατέργαστου μεταλλακτικού βακτηριακού στελέχους κυττάρων, που περιλαμβάνει: (α) εκχύλιση των κυττάρων με διάλυμα που συνίσταται βασικά από τουλάχιστον 75 % κατά βάρος από μια αλειφατική αλκοόλη έχουσα από 1 έως 4 άτομα άνθρακα και το υπόλοιπο είναι νερό, παράγοντας με τον τρόπο αυτό κύτταρα με μειωμένη περιεκτικότητα φωσφολιπιδίου και (β) εκχύλιση των κυττάρων με μειωμένη περιεκτικότητα φωσφολιπιδίου με ένα διάλυμα που περιλαμβάνει χλωροφόρμιο και μεθανόλη, αποδίδοντας με τον τρόπο αυτό ένα διάλυμα LPS σε χλωροφόρμιο και μεθανόλη (CΜ). Αυτή η μέθοδος παρέχει διαλύματα LPS σε CΜ που έχουν μειωμένη περιεκτικότητα φωσφολιπιδίου και παράγονται με σχετικά απλά και φθηνά στάδια μεθόδου.
Patent CY-1114272-T1 (CY)
Title: Υποκατεστημενες διυδροπυραζολονες για την θεραπευτικη αντιμετωπιση των καρδιαγγειακων και αιματολογικων παθησεων
Inventor: THEDE KAI
IPC: C07D417/14
Filed: 2013-08-21
Abstract: Η εφεύρεση αναφέρεται σε παράγωγα διυδροπυραζολόνης του τύπου (Ι), σε μεθόδους για την παραγωγή τους, στην χρήση τους για την θεραπευτική αντιμετώπιση και/ή για την πρόληψη των ασθενειών, καθώς και στην χρήση τους για την παραγωγή φαρμάκων με σκοπό την θεραπευτική αντιμετώπιση και/ή με σκοπό την πρόληψη ασθενειών, και ιδίως καρδιαγγειακών και αιματολογικών ασθενειών, ασθενειών των νεφρών και με σκοπό την ενίσχυση της επούλωσης των πληγών.
Patent CY-1116406-T1 (CY)
Title: Αντισωματα enanti-cd33 και μεθοδος για τη θεραπευτικη αγωγη οξειας μυελοειδους λευχαιμιας με τη χρηση των ιδιων
Inventor: HOFFEE MARY G
IPC: C12N5/06
Filed: 2015-06-19
Abstract: Η παρούσα εφεύρεση αφορά αντισώματα τα οποία δεσμεύουν CD33. Πλέον συγκεκριμένα η εφεύρεση αφορά αντισώματα έναντι-CD33, θραύσματα και ομόλογα των εν λόγω αντισωμάτων, ανθρωποποιημένες εκδόσεις και εκδόσεις αναδιαμορφωμένης επιφάνειας των εν λόγω αντισωμάτων, λειτουργικά ισοδύναμα και βελτιωμένες εκδόσεις των εν λόγω αντισωμάτων, ανοσοσυζεύγματα και συνθέσεις οι οποίες περιλαμβάνουν τα εν λόγω αντισώματα και τις χρήσεις των ιδίων σε διαγνωστικές, ερευνητικές και θεραπευτικές εφαρμογές. Η εφεύρεση αφορά επίσης ένα πολυνουκλεοτίδιο το οποίο κωδικοποιεί τα αντισώματα, φορείς οι οποίοι περιλαμβάνουν τα πολυνουκλεοτίδια, κύτταρα ξενιστή μετασχηματισμένα με πολυνουκλεοτίδια και μεθόδους παραγωγής των αντισωμάτων.
Patent CY-1116583-T1 (CY)
Title: Χιμαιρικα vlps γριπης των πτηνων
Inventor: SMITH GALE
IPC: A61K39/155
Filed: 2015-07-14
Abstract: Η εφεύρεση αυτή αποκαλύπτει μέθοδο αύξησης παραγωγής των ομοιαζόντων με ιό σωματιδίων που περιλαμβάνουν έκφραση μιας πρωτεΐνης μήτρας γρίπης των πτηνών. Η εφεύρεση επίσης περιλαμβάνει μεθόδους κατασκευής και χρήση των εν λόγω VLPs.
Patent CY-1116731-T1 (CY)
Inventor: LAMPING NORBERT
IPC: A61K39/00
Filed: 2015-07-29
Abstract: A modular antigen-transporting molecule (MAT) comprising one each of a translocation module (TrM), a targeting module (TaM) and an antigen module (AM), is new.  Modular antigen-transporting molecule (MAT) comprising at least one each of translocation module (TrM), targeting module (TaM) and antigen module (AM) is new. TrM is able to transport MAT from the extracellular space into a cell; TaM directs transport of MAT to organelles involved in processing of antigens (Ag) or loading of MHC (major histocompatibility complex) molecules, and AM determines the specificity of the immune response induced by MAT.  Independent claims are also included for the following: (1) method for preparing MAT;  (2) nucleic acid (I) that encodes MAT;  (3) vector containing (I) and preferably at least one of promoter, antibiotic or antimycotic resistance gene;  (4) primary cells or cell lines containing a vector of (3) or (I);  (5) vesicles, especially exosomes, deoxosomes or liposomes that contain at least one MAT, (I) or the vector of (3);  (6) immunoglobulins (Ig), or their fragments, that recognize MAT, prepared by immunization of a human or animal;  (7) method for identifying substances that inhibit or stimulate presentation of Ag through the MHC;  (8) method for identifying specific epitopes of Ag;  (9) in vitro cultured cells, human or animal, that have been treated with MAT, (I), the vector of (3) or vesicle of (5) and show modulated Ag presentation; and  (10) method for preparing antibodies (Ab), using MAT, (I), vesicles of (5), or cells of (4) or (9), by immunization.