Patent SG-11201810048V-A (SG)
Title: Tri-segmented pichinde viruses as vaccine vectors
Inventor: BONILLA WELDI
IPC: C07K14/005
Filed: 2017-05-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 11 11111111111111 0101110111011111111110111111011110111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/198726 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: C12N 15/86 (2006.01) CO7K 14/005 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/EP2017/061865 claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) — 17 May 2017 (17.05.2017) with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/338,400 18 May 2016 (18.05.2016) US (71) Applicants: HOOKIPA BIOTECH AG [AT/AT]; Helmut-Qualtinger-Gasse 2, 1030 Wien (AT). UNIVERSITAT BASEL [CH/CH]; Vizerektorat Forschung, Petersgraben 35, 4001 Basel (CH). (72) Inventors: BONILLA, Weldi; Im Zehntenfrei 5, 4102 Bin- ningen (CH). PINSCHEWER, Daniel David; Im Zehnten- _ frei 5, 4102 Binningen (CH). ORLINGER, Klaus; Schatz- gasse 4/1, 1190 Wien (AT). — = (74) Agent: JONES DAY (ASSOCIATION NO. 215); PrinzregentenstraBe 11, 80538 Mfinchen (DE). = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (81) — — = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) _ _ kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = 1-1 ei IN (54) Title: TRI-SEGMENTED PICHINDE VIRUSES AS VACCINE VECTORS GC 0\ (57) : The present application relates to Pichinde viruses with rearrangements of their open reading frames (\"ORF\") in their 1-1 ---- genomes. In particular, described herein is a modified Pichinde virus genomic segment, wherein the Pichinde virus genomic segment IN IN is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented © Pichinde virus particles comprising one L segment and two S segments or two L segments and one S segment. The Pichinde virus, N described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies. C