baber/WOPTO huggingface dataset:
Patent CA-2671728-A1 (CA)
Title: Pharmaceutical composition comprising a hot-melt granulated lubricant
Inventor: AKBARIEH MOSTAFA
IPC: A61K9/20
Filed: 2007-12-19
Abstract: The present invention relates to a lubricant granulate prepared using a hot melt granulation process, or thermal-heat process. The lubricant granulate is useful in facilitating the use of higher concentrations of lubricant than typically possible in pharmaceutical compositions. Also provided are pharmaceutical compositions comprising the lubricant granulate. Such pharmaceutical compositions can contain bisphosphonic acid as the active ingredient and can be suitable for oral administration. The present invention also provides a hot melt process for preparing the lubricant granulate for subsequent use in pharmaceutical compositions.
Patent CA-2673038-A1 (CA)
Inventor: FOLMER BEVERLY
IPC: C07D487/04
Filed: 2007-12-20
Abstract: The present invention provides substituted tricyclic heteroaryl compounds , including, for example, pyridoindoles, pyrimidinoindoles and triazinoindol es that modulate the activity of Janus kinases and are useful in the treatme nt of diseases related to activity of Janus kinases such as immune-related d iseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
Patent CA-2674573-A1 (CA)
Title: Substituted spirochromanone derivatives
Inventor: YAMAKAWA TAKERU
IPC: C07D495/04
Filed: 2008-01-08
Abstract: The invention relates to a compound of a general formula (I): (I) wherein Ar1represents a group formed from an aromatic ring selected from a group consisting of indole, 1H-indazole, 2H-indazole, 1H-thieno[2,3-c]pyrazole, 1H-pyrazolo[3,4-b]pyridine, benzo[b]furan, benzimidazole, benzoxazole, 1,2-benzisoxazole and imidazo[1,2-a]pyridine; R1 and R2 each represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; an optionally-substituted C1-C6 alkyl, aryl or heterocyclic group; or a C1-C6 alkyl or C2-C6 alkenyl group having the aryl or heterocyclic group; R3 and R4 each represent a hydrogen atom, a halogen atom, a nitro group, a cyclo-C3-C6 alkyl group, a carbamoyl group optionally substituted with a C1-C6 alkyl or cyclo-C3-C6 alkyl group, or a group of -N(Re)Rf; an optionally-substituted C2-C7 alkanoyl, C1-C6 alkoxy, C2-C7 alkoxycarbonyl, cyclo-C3-C6 alkyloxycarbonyl, C1-C6 alkylsulfonyl, C1-C6 alkylthio, cyclo-C3-C6 alkyloxy, cyclo-C3-C6 alkyl-C1-C6 alkoxy, cyclo-C3-C6 alkylsulfonyl, cyclo-C3-C6 alkylthio or cyclo-C3-C6 alkyl-C1-C6 alkylthio group; or an optionally-substituted C1-C6 alkyl group; T and U each represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
Patent CA-2677896-A1 (CA)
Title: Implement for orientating a surgical tool
Inventor: FUERST YARON
IPC: A61B17/56
Filed: 2008-02-03
Abstract: An implement for orientating a tool at a predetermined angle with respect to a plane of a target surface to be engaged by the tool includes a rod having a distal end coupled to a head formed with three contact points arranged in a circular array around the longitudinal axis of the rod, such that the three contact points define a plane. The rod is coupled to the head with the longitudinal axis of the rod at the predetermined angle to the plane defined by the three contact points, such that when the three contact points of the rod are in contact with the target surface, the longitudinal axis of the rod is at the predetermined angle with respect to the plane of the target surface. The implement is described particularly for orientating a surgical cutting tool perpendicularly to bone tissue for harvesting and implanting a bone plug to repair damaged bone tissue.
Patent CA-2678382-A1 (CA)
Title: New substituted arylsulphonylglycines, the preparation thereof and the use thereof as pharmaceutical compositions
Inventor: LANGKOPF ELKE
IPC: C07D401/14
Filed: 2008-02-15
Abstract: The present invention relates to substituted arylsulphonylglycines of general formula wherein R, R4, X, Y, Z and m are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen- associated protein phosphatase 1 (PP1 ), and their use as pharmaceutical compositions.
Patent CA-2678645-A1 (CA)
Inventor: DENNY CHRIS
IPC: F16K31/62
Filed: 2008-02-20
Abstract: A faucet controller for operating a valve mounted in association with a faucet, having a joystick actuator mountable on the valve for movement between a normal at rest position and a valve operating position, and a whisker connected with the joystick for forcing the joystick actuator into the valve operating position.
Patent CA-2679471-A1 (CA)
Title: System and method for graphically displaying energy consumption and savings
Inventor: JACOBY ELLIOT G JR
IPC: G01R21/133
Filed: 2008-03-10
Abstract: A system for displaying an electronic representation of the consumption of a resource by a device comprises a communication network, a database, and visual display. The database is accessible by an information processor of the network and stores information including a maximum rated amount of the resource consumed by the at least one device and the actual amount of the resource consumed by the at least one device. The visual display provides an electronic representation of the resource, the amount of the resource consumed by the at least one device and the amount of the resource saved as a function of the electronic device information, wherein the visual display presents the electronic representation in a graphical format with a range of values and an indicator of an indicated value in the range. The range of values is operable to dynamically change when the consumption of the resource exceeds the maximum rated amount.
Patent CA-2681636-A1 (CA)
Inventor: BUCCI GEORGE
IPC: H05B37/02
Filed: 2008-03-27
Abstract: Systems for reducing the power consumption of fluorescent lights are provided. The systems can be used in new construction as well as retrofitted into existing buildings employing overdriven fluorescent lights without significantly affecting the operation of utility power lines. In preferred embodiments, the systems provide substantially constant light output during start-up and low voltage conditions.
Patent CA-2682165-A1 (CA)
Title: Determining a geolocation solution of an emitter on earth based on weighted least-squares estimation
Inventor: CHU JEFFREY C
IPC: G01S3/02
Filed: 2008-04-11
Abstract: Embodiments provide systems and methods for determining the geolocation of an emitter on earth based on weighted least-squares estimation based on two TDOA and two FDOA measurements, none of which need to be acquired at the same time. The four TDOA and FDOA measurements and the errors in each of the measurements are determined. Weights for the errors in the TDOA and FDOA measurements are determined, and the weights are applied in a weighted errors function. The weights account for the errors in the measurements and the errors in the satellite positions and velocities, and are dependent on the localization geometry. The weighted errors function is minimized to determine the location estimate of the unknown emitter.
Patent CA-2682610-A1 (CA)
Title: A system and method for merchant discovery and transfer of payment data
Inventor: DRAKE-STOKER RYAN FREDRICK
IPC: G06Q20/00
Filed: 2008-03-31
Abstract: A method and system are provided for communicating with a merchant server and transferring payment data in a transaction between a mobile device and a merchant server. A user of the mobile device has a user identifier registered with the system and the merchant server has a merchant identifier registered with the system. The method comprises the steps of: receiving the merchant identifier from the mobile device; determining a merchant server address associated with the merchant identifier; establishing a communication channel with the merchant server; exchanging interactive information requests and responses between the merchant server and the mobile device; determining payment data associated with the user identifier; and providing the payment data to the merchant server.
Patent CA-2682774-A1 (CA)
Inventor: INDIVERI FRANCESCO
IPC: G01N33/564
Filed: 2008-04-11
Abstract: The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+ T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.
Patent CA-2683950-A1 (CA)
Title: Interactive information system for an airplane
Inventor: RODAT PETER
IPC: G06F3/048
Filed: 2008-06-25
Abstract: An interactive information system is indicated for an aircraft to provide passengers with information, which access both an onboard data storage device and an off-board data storage device. A computer uses the onboard and off-board data to compute informative data, which are then visualized to the passenger. The passenger can interactively determine the form and type of data generation and preparation at any time.
Patent CA-2684367-A1 (CA)
Inventor: SIMPSON ROBERT DAVID
IPC: E05C17/36
Filed: 2008-04-25
Abstract: A security device for a closure leaf such as a door or window comprises: a link member extending between a portion of said security device located on said closure leaf to which said link member is attached, in use, and a portion of said security device located adjacent to said closure leaf to which said link member is attached, in use; whereby said link member restrains the opening of said closure leaf beyond a predetermined degree; a canister of pressurised substance; a canister holder for securing said canister on a support structure; whereby said canister is in a position for spraying a subject in the vicinity of said closure leaf; and an actuator which engages said link member and which applies pressure to said canister when pressure is exerted on said closure leaf beyond a predetermined level; whereby said canister sprays.
Patent CA-2685044-A1 (CA)
Inventor: HILL AARON L
IPC: A61L2/28
Filed: 2008-04-21
Abstract: A method and apparatus for calibrating a sensor used to sense the concent ration of vaporized hydrogen peroxide (VHP). A concentration of liquid hydro gen peroxide in an aqueous solution is determined and correlated with a corr esponding concentration of vaporized hydrogen peroxide indicative of an "act ual" vaporized hydrogen peroxide concentration. An error value is determined by comparing the "actual" vaporized hydrogen peroxide concentration to a "m easured" vaporized hydrogen peroxide concentration, indicated by the sensor being calibrated. The error value is used to properly calibrate the sensor.
Patent CA-2685321-A1 (CA)
Inventor: MODI PANKAJ
IPC: A61K31/167
Filed: 2009-11-18
Abstract: A nano particle drug delivery system comprised of micelles coated with lipid molecules for the non-invasive deployment and absorption of active anesthetic compounds through the stratum corneum and throughout the skin and sub cutaneous tissue without any cutaneous toxicity.
Patent CA-2686796-A1 (CA)
Inventor: THORLEY JEB STUART
IPC: G06F21/00
Filed: 2009-12-01
Abstract: Method and system using a designated known secure computer for real time classification of change events in a computer integrity system are disclosed.  In the embodiment of the invention, the known secure computer is dedicated for providing permissible change events, which are compared with change events generated on client operational computers. An alert is raised when the change event at the client operational computer and the respective permissible change event provided by the known secure computer differ.
Patent CA-2687262-A1 (CA)
Title: One-pot production process for cinnamide derivative
Inventor: IMAI AKIO
IPC: C07D401/10
Filed: 2008-05-15
Abstract: A compound represented by the formula (1) below or a pharmaceutically acceptable salt thereof is able to be produced in one pot by reacting a compound represented by the formula (2) below with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base, and if necessary, by removing a protecting group. (In the formula (2), R1 represents a 4-fluorophenyl group or the like; Q represents -CH(CH3)- or the like; and n represents 1 or the like.) (In the formula (1), R represents a 4-fluorophenyl group or the like; and Q and n are as defined above.)
Patent CA-2687535-A1 (CA)
Inventor: JURK MARION
IPC: A61P31/00
Filed: 2008-05-15
Abstract: L'invention porte sur des oligonucléotides comprenant au moins une modification de squelette et un dinucléotide pyrimidine-purine. L'invention porte également sur des compositions pharmaceutiques et sur leurs procédés d'utilisation.
Patent CA-2688664-A1 (CA)
Title: Chauffe-eau et methode d'utilisation
Inventor: CAVES ANDREW ROBERT
IPC: F24H9/20
Filed: 2009-12-16
Abstract: Un chauffe-eau de type à stockage comporte un réservoir pour contenir l'eau à chauffer, une première rangée de chauffage comprenant une première surface de chauffage disposée à l'intérieur du réservoir, un premier contacteur relié à la première rangée de chauffage, une deuxième rangée de chauffage comprenant une deuxième surface de chauffage disposée dans le réservoir, un deuxième contacteur relié à la deuxième rangée de chauffage, et un contrôleur pour faire fonctionner de manière sélective les premier et deuxième contacteurs.
Patent CA-2690835-A1 (CA)
Inventor: NELSON J RICHARD
IPC: B26D1/547
Filed: 2009-04-17
Abstract: A device and method for separating adhesive includes a gear and a tension element.     The device may be designed to stall before the tension element can break.
Patent CA-2692263-A1 (CA)
Inventor: NERI DARIO
IPC: A61P35/00
Filed: 2008-06-25
Abstract: This invention relates to the treatment of cancer using anti-cancer agents, such as doxorubicin or paclitaxel, in combination with antibody- interleukin 2(IL2) conjugates which target tenascin-C.
Patent CA-2693138-A1 (CA)
Inventor: GROSS JONATHAN LAIRD
IPC: C07D413/14
Filed: 2008-07-15
Abstract: The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
Patent CA-2695727-A1 (CA)
Inventor: KAMOR MICHAEL
IPC: H01H71/24
Filed: 2010-03-04
Abstract: A circuit interrupting device configured to cause electrical discontinuity along a conductive path upon the occurrence of a predetermined condition is disclosed.  The device includes a fault sensing circuit detecting the predetermined condition and generating a circuit interrupting actuation signal, and a coil and plunger assembly actuatable by the circuit interrupting actuation signal so that, upon detecting the predetermined condition, the plunger will move in a fault direction from a non-actuated to an actuated configuration a distance sufficient to cause disengagement of at least one set of contacts from each other to cause electrical discontinuity along the conductive path; and a test assembly causing the plunger to move in a test direction, from a pre-test configuration to a post-test configuration, a distance insufficient to disengage the at least one set of contacts from each other. Analogous methods of testing the circuit interrupting device are also disclosed.
Patent CA-2698079-A1 (CA)
Title: A cell therapy method for the treatment of tumors
Inventor: DEGRAW JULI
IPC: C12P21/08
Filed: 2002-02-19
Abstract: T cell responses are often diminished in humans with a compromised immune system.  We have developed a method to isolate, stimulate and expand naïve cytotoxic T  lymphocyte precursors (CTLp) to antigen-specific effectors, capable of lysing tumor cells in vivo. This ex vivo protocol produces fully functional effectors.  Artificial antigen presenting cells (AAPCs; Drosophila melanogaster) transfected with human HLA  class I and defined accessory molecules, are used to stimulate CD8+ T cells from both normal donors and cancer patients. The class I molecules expressed to a high density on the surface of the Drosophila cells are empty, allowing for efficient loading of multiple peptides that results in the generation of polyclonal responses recognizing tumor cells endogenously expressing the specific peptides. The responses generated are robust, antigen-specific and reproducible if the peptide epitope is a defined immunogen. This artificial antigen expression system can be adapted to treat most cancers in a significant majority of the population.
Patent CA-2700164-A1 (CA)
Inventor: ALTERMANN ERIC HEINZ
IPC: C07H21/04
Filed: 2008-09-25
Abstract: The invention encompasses phage .phi.mru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors. The invention further encompasses compositions and methods for detecting, targeting, permeabilising, and inhibiting microbial cells, especially methanogen cells, using the disclosed phage, polypeptides, polynucleotides, expression vectors, or host cells.
Patent CA-2702232-A1 (CA)
Inventor: MAHURKAR SAKHARAM D
IPC: A61M5/34
Filed: 2010-05-03
Abstract: A syringe comprises a generally-cylindrical, hollow barrel with a hollow nozzle at a distal end thereof. A plunger with an open channel is slidably mounted in the barrel. A needle holder with a needle mounted at one end thereof is arranged in the plunger channel, and movable between an advanced position, whereat the needle projects from a distal end of the nozzle for injection, and a retracted position, whereat the needle is enclosed within the barrel when the injection is complete. A spring retainer is arranged in the barrel. A spring is positioned within the spring retainer, urging the needle holder toward the retracted position. A latch latches the needle holder to the spring retainer thereby maintaining the spring in compression. The latch is releasable in response to the plunger moving to its fully advanced position, whereby the needle holder is released, allowing the spring to expand and thereby move the needle holder to the retracted position.
Patent CA-2703072-A1 (CA)
Title: Iterative reservoir surveillance
Inventor: SEQUEIRA JOSE J
IPC: G01V1/00
Filed: 2008-10-20
Abstract: Method for reservoir surveillance using a three-dimensional Earth Model (101) to improve and expedite the surveillance at all scales of investigation (field, reservoir, fault compartment, and individual well) and at all time steps (minutes, hours, days, months, years). The new method allows users to rapidly identify anomalous field and well performance (109) and provides capability to investigate root causes of the performance deviation from predicted (110). Animated co-rendered displays (107) of the earth model and actual (104) and simulated (105) production data enable the user to interactively determine model adjustments back at the basic level of the Earth Model, which are then propagated to a geologic model (102) and then to the reservoir simulator (103) to update it (111) in a physically constrained way.
Patent CA-2704818-A1 (CA)
Inventor: PATEL SMITA
IPC: A01N25/14
Filed: 2008-10-28
Abstract: The use of mixtures of different plant protectant active substance granule particles which remain homogeneous upon storage, handling and application, for the stable storage of mixing-incompatible active substances, and a preparation process therefor.
Patent CA-2720149-A1 (CA)
Title: Systeme d'aeration demontable pour modifier en rattrapage une cellule a grains
Inventor: VARRO IMRE
IPC: A01F25/22
Filed: 2010-11-03
Abstract: Selon l'invention, un nouveau système d'aération affaissable est rétro-ajusté dans un compartiment à grains présentant une ouverture de décharge dans la partie inférieure. Ce compartiment à grains peut avoir une trémie inclinée ou conique ou un fond plat. Le système d'aération est formé à partir d'un ensemble de sections de conduit reliées (par exemple articulées) qui définissent un conduit arrondi ou à multiples côtés ayant un minimum de trois côtés ou faces. Les côtés peuvent être plats, incurvés ou ondulés. Le système d'aération affaissable est plié (affaissé), introduit dans le compartiment par un trou, puis déplié à l'intérieur du compartiment. Un conduit d'air est relié au système d'aération pour permettre au système d'aération de sécher le grain dans le compartiment à grains. Cette technologie permet aux compartiments à grains existants d'être rétro-ajustés avec un séchoir d'une manière aisée et efficace.
Patent CA-2723721-A1 (CA)
Inventor: TURNELL WILLIAM G
IPC: A61M37/00
Filed: 2009-05-07
Abstract: The invention provides metal-chelating poly (ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution.
Patent CA-2727190-A1 (CA)
Title: Systeme et procede automatises de nettoyage et manipulation de tapis
Inventor: COTTER ROBERT
IPC: A47L13/00
Filed: 2009-06-18
Abstract: L'invention porte sur un système automatisé conçu pour laver et sécher les tapis. Ledit système comprend un nombre de modules, y compris un module de chargement, un module vibratoire, un module de vide et un module de déchargement. Le système selon l'invention offre également la possibilité d'inspecter manuellement les tapis. Etant donné que les tapis introduits dans le système sont d'abord agités et secoués avant d'être lavés, leur nettoyage nécessite des quantités réduites de produits chimiques et d'eau, et une moindre énergie de séchage et pression d'eau. Le système précité peut également comprendre un appareil de défilement et de tri automatique qui fait défiler les tapis et les trie selon leur poids, leur taille, etc., après qu'ils ont été déchargés par le module de déchargement. L'invention concerne aussi un procédé de nettoyage de tapis.
Patent CA-2728825-A1 (CA)
Inventor: CHAUDHRI APOORV
IPC: H04W16/14
Filed: 2009-08-18
Abstract: A technique for spectrum sensing management and control for a secondary communication system seeking to utilize another communication system's spectrum is provided (600) Sensor control data is sent from a base station to subscriber units (604) Sensing measurements are taken and sent back to the base station for ranking (608) as sensed feedback information. Comparisons of the sensed feedback information are made to each other and to thresholds aligned with the types of measurements taken (610). An initial ranked channel list is generated (612) Weighting of the initial ranking list and secondary ranking list is followed by re-ranking the channels according to the weighting into a final ranking list (612). The final ranking list is transmitted to the mobile units to enable operation within the other communication system's spectrum within interfering with that system (614). The weighting is based on the type of sensing measurement taken as opposed to the channel.