baber/WOPTO huggingface dataset:
Patent NZ-222852-A (NZ)
Title: Imidazole derivatives: medicaments.
Inventor: VIYYOOR MOOPIL GIRIJAVALLABHAN
IPC: C07D307/20
Filed: 1987-12-09
Abstract: The disclosed invention is compounds represented by the formula <CHEM> and pharmaceutically acceptable acid addition, basic addition and quarternary amine salts thereof and pharmaceutically acceptable solvates thereof, wherein each Z is independently tetiary butyl, phenyl, naphthyl or adamantyl; substituted phenyl, wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenyslsulfonyl, loweralkylsulfonyl, oxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, lower alkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl; 4 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen with the remaining members of the ring being at least one carbon, and optionally sulfur or oxygen, wherein the substituents are one or more of carboxyl, hydroxymethyl, lower alkyl, loweralkylcarbonyl or aryl lower alkyl;  X and Y are each independently a bond, -O-, <CHEM> each Q is independently a divalent substituted or unsubstituted, straigh or branched chain lower alkanediyl, lower alkanediyl-cycloalkaneidyl-lower alkanediyl, lower alkenediyl, lower alkynediyl, phenylene, dihydrofurandiyl, tetrahydrofurandiyl, tetrahydropyrandiyl, or, loweralkanediyl-tetrahydrofurandiyl-loweralkanediyl, wherein the substituents are one or more of hydroxy, epoxy, fluorine, chlorine, azide, or amino; W is a monovalent substituted or unsubstituted aryl group or a heterocyclic single or fused ring containing from 4 to 10 ring atoms, at least one hetero atom of which is a nitrogen atom and the remaining ring atoms being at least one carbon and optionally sulfur or oxygen, wherein the substituents are one or more of hydroxy, oxo amino, carbamoyl, carboxyl, nitrile, nitro, lower alkoxy carbonyl, halogen, sulfamyl, lower alkyl, lower alkylthio, lower alkoxy, hydroxyloweralkyl, lower alkoxycarbonylloweralkyl, amino loweralkyl, carboxyloweralkyl, guanidino, thioureido, lower alkylsulfonylamino, aminocarbonylloweralkyl, allyloxycarbonylmethyl or carbamoyloxyloweralkyl; with the proviso that W cannot be substituted or unsubstituted isoxazolyl, and  W' is divalent W. The compounds have antiviral activity, antiinflammatory activity and are PAF inhibitors.
Patent NZ-228712-A (NZ)
Title: 3-substituted-2-oxindole-1-carboxamides for suppressing t-cell function
Inventor: SHOWELL HENRY JAMES
IPC: A61K31/40
Filed: 1989-04-12
Abstract: This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula <CHEM> and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H or Cl; and R is benzyl or thienyl to suppress T-cell function in a mammal. This invention also relates to the use of such compounds for treating T-cell mediated autoimmune disorders of the systemic or organ specific type. The methods of this invention comprise administering a T-cell function suppressing amount of the compounds and salts of this invention to such a mammal.
Patent NZ-233063-A (NZ)
Title: Contact lens: pattern of coloured lines in iris portion
Inventor: RAWLINGS DAVID LIONEL
IPC: G02B1/04
Filed: 1990-03-23
Abstract: A molded plastic cosmetic contact lens made in a repetitive manner comprising a cosmetic pattern of clustered networks of interconnected thin colored lines radiating from and about the periphery of the pupil portion in a direction inclined towards and in contact with the periphery of the iris portion and residing within the iris portion. The lens can be made by molding in a manner that the cosmetic pattern becomes part of the body of the lens.
Patent NZ-233341-A (NZ)
Title: Fuel filter including contaminant trap and vibratable separator
Inventor: SUSSICH MARINO ROBERT
IPC: B01D29/62
Filed: 1990-04-18
Abstract: A filter assembly for filtering contaminants from liquid. A housing has a filtering chamber and an inlet port and an outlet port communicating with the chamber for flow of liquid therethrough. Filter media is located in the filtering chamber for filtering contaminants from liquid flowing through the chamber. A sump region is provided in the filtering chamber for collection of contaminants from the liquid, and a separator member is located in the filtering chamber and substantially separating the filter media and sump region. The separator member provides for communication of the contaminants into the sump region but tends to trap contaminants from the liquid received in the sump region.
Patent NZ-233860-A (NZ)
Title: Substituted quinoline derivatives
Inventor: GUNNARSSON PER-OLOV
IPC: A61P37/00
Filed: 1990-05-30
Abstract: The present invention concerns novel compounds having general formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<7> are selected from the group consisting of hydrogen, hydroxy and methoxy. At most one of R<1>, R<2> and R<3> and at most one of R<4>, R<5>, R<6> and R<7> is selected from the group consisting of hydroxy and methoxy. M is selected from the group consisting of hydrogen and pharmaceutically acceptable inorganic or organic cations or tautomeric forms thereof. The compounds have immunomodulating activity.
Patent NZ-238005-A (NZ)
Title: Dispenser for flowable substances: spout pierces and seals against pouch
Inventor: KING DAVID CAMPBELL
IPC: B05C17/005
Filed: 1991-05-01
Abstract: A dispenser of flowable materials from a pouch is disclosed. The pouch has an ear (55) at each of the ends of a transverse seal (53) located at one end of the pouch (57). The dispenser comprises i) a cylindrical container (33) having sides and an open top having a rim, the container being adapted to contain the pouch, and ii) a lid (35) attachable to the rim such that the lid is adapted to trap the ears of the pouch between the lid and the rim and to keep said end of the pouch taut between the ears when the lid is attached to the rim. The lid is also being adapted to allow a spout (41) to pierce the pouch at the taut portion.
Patent NZ-239586-A (NZ)
Title: Thixotropic phenol-aldehyde laminating resin and laminates thereof
Inventor: FRANCIS ROBERT STRADLING
IPC: C08K5/06
Filed: 1991-08-29
Abstract: This invention relates to a thixotropic laminating resin composition comprising an acid hardenable phenol-aldehyde resin, a highly dispersed hydrophobic amorphous silica and a viscosity modifier wherein the composition has a specified viscosity. Composites laminated with the above composition have improved dimensional stability and are resistant to combustion or smoke emission.
Patent NZ-292491-A (NZ)
Title: Adding calcium and aluminium to molten lead: calcium and aluminium particles fed into melt through rotary impeller
Inventor: HIBBINS STEPHEN GEORGE
IPC: B01F27/91
Filed: 1995-09-19
Abstract: Process and apparatus for adding calcium and aluminum to molten lead to produce a lead-calcium alloy suitable for battery grids. Particles of calcium and aluminum metal or alloys thereof are fed into the interior of a tubular housing having a wall extending down into the molten lead and having a bottom opening at a relatively large depth below the lead surface and having openings in its wall at a relatively small depth below the lead surface. A rotary impeller which acts at least partially as a centrifugal impeller is positioned in the housing to cause swirling of lead carrying the particles within the housing, the shape of the housing and the nature and position of the impeller being such as to ensure that lead carrying the particles is swirled against the housing wall and recirculated within the housing before the lead leaves the housing.
Patent NZ-292983-A (NZ)
Title: Aminoheterocyclic derivatives, preparation and pharmaceutical compositions thereof
Inventor: FAULL ALAN
IPC: A61K31/535
Filed: 1995-09-25
Abstract: The invention concernscompounds of formula (I), wherein each of G1, G2 and G3 is CH or N; m is 1 or 2; R1 includes hydrogen, halogeno and 1-C)alkyl; M1 is a group of formula: NR2-L1-T1R3, in which R2 and R3 together form a (1-4C)alylene group, L1 includes (1-4C)alkylene, and T1 is CH or N; A may be a direct link; M2 is a group of the formula: (T2R4)rL2-T3R5 in which R is 0 or 1, each of T2 and T3 is CH or N, each of R4 and R5 is hydrogen or (1-4C)alkyl, or R4 and R5 together form a (1-4C)alkylene group, and L2 includes (1-4C)alkylene; M3 may be a direct link to X; X includes sulphonyl; and Q includes naphthyl and a heterocyclic moiety; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use as antithrombotic or anticoagulant agents.
Patent NZ-297795-A (NZ)
Title: Malonic acid based matrix metalloproteinase inhibitors
Inventor: MORODER LUIS
IPC: A61P29/00
Filed: 1995-12-08
Abstract: There is described the use of a compound represented by general formulae (I), (II) or (III), for the inhibition of matrix metalloproteinases (MMP), wherein X1 is oxygen or sulfur, R1 is OH, SH, CH2OH, CH2SH or NHOH, R2 is a residue of 2 to 10 hydrocarbon backbone atoms, which binds to the amino acid 161 of HNC, said residue being saturated or unsaturated, linear or branched, and contains preferably homocyclic or heterocyclic structures, X2 is oxygen or sulfur and binds as hydrogen acceptor on amino acid 160 of HNC, Y is a residue which binds to the S1' pocket of HNC and consists of at least 4 backbone atoms Z1-Z2-Z3-Z4-R3, and R3 is n-propyl, isopropyl, isobutyl or a residue with at least 4 backbone atoms, which is not larger than a tricyclic ring system. These compounds bind to MMPs in a manner different from the mode of binding of the inhibitors of the state of the art.
Patent NZ-330866-A (NZ)
Title: Methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells
Inventor: MONTMINY MARC R
IPC: C12Q1/6897
Filed: 1997-01-22
Abstract: An in vitro method for determining an ability of a test compound to stimulate pancreatic islet cells to induce STF-1 transcription, comprising the steps of: 1. providing a vector containing an STF-1 enhancer having a sequence selected from the group SEQ ID No:l or SEQ ID No:2 or fragments thereof, a promoter, and a reporter gene under the transcriptional control of both the STF-1 enhancer and the promoter, wherein the reporter gene is capable of conferring a detectable signal to pancreatic islet host cells;  2. transferring the vector into the host cell; 3. culturing the host cell in the presence of a test compound to determine an ability of the test substance to stimulate the host cell to produce the signal; and 4. assaying for the signal to determine the ability of the test compound to stimulate the host cell to produce the detectable signal. The presence of the signal indicates that the test compound stimulates pancreatic islet cells to induce STF-1 transcription, and wherein an absence of the signal indicates that the test compound does not stimulate pancreatic islet cells to induce STF-1 transcription.
Patent NZ-331176-A (NZ)
Title: Receptor protein designated 2F1, DNA encoding 2F1, preparation and use thereof
Inventor: PARNET PATRICIA
IPC: C12P21/08
Filed: 1997-02-06
Abstract: An isolated DNA encoding 2F1 protein, expression vectors comprising isolated DNA, and a method for producing 2F1 by cultivating host cells transformed with the expression vectors under conditions appropriate for expression of the 2F1 protein. Antibodies directed against 2F1 are also disclosed. 2F1 are useful in inhibiting prostaglandin synthesis and alleviating inflammation.
Patent NZ-332587-A (NZ)
Title: solid fuel heater control apparatus being temperature sensor, air inlet valve and controller for valve responsive to sensor, and indicator operated by control element to indicate amount of fuel remaining in combustion chamber
Inventor: KEEMAN WILHELMUS BERNARDUS MAR
IPC: F24B1/187
Filed: 1999-12-22
Abstract: Controller 8 senses flue and/or external temperature via sensor(s) 6,7 and via solenoid 9 operates inlet valve 4 of solid fuel heater 1.  An indicator is provided (typically with the controller 8) which indicates fuel left in the combustion chamber of the heater, indirectly by the effect of opening of valve 4.  Typically if valve is opened further and the heater or room temperatures do not rise significantly then it is deduced that fuel is at a low level.
Patent NZ-337376-A (NZ)
Title: Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
Inventor: DUPONT ERIC
IPC: A61K35/32
Filed: 1998-03-11
Abstract: Cartilage extract having anti tumour activity is used in combined anti tumour therapy to increase the anti tumour activity of an anti neoplastic in a patient and to protect the patient against toxic side effects inherent to the administration of the anti neoplastic. A pharmaceutical composition containing an anti neoplastic and a cartilage extract is useful to protect the patient against toxic side effects inherent to the administration of the anti neoplastic.
Patent NZ-501636-A (NZ)
Title: Multilayer barrier packaging film including a coextrusion of at least four layers
Inventor: GINOSSATIS STAMATIS
IPC: B32B27/08
Filed: 1998-05-15
Abstract: A multilayer barrier packaging film suitable for use in fabricating bags for packaging primal and sub-primal meat cuts and processed meats, is disclosed.  The multilayer barrier packaging film includes an irradiated biaxially orientated coextrusion of at least four layers which includes at least two layers of a thermoplastic polymer or copolymer and at least two relatively thin thermoplastic polymer oxygen barrier layers.  Alternatively, the packaging film includes a coextrusion of at least four layers having outer shrinkable layers and at least two PVDC (copolymer of vinylidene dichloride) barrier layers, each having a thickness of at least 2.5m and a total thickness of PVDC of less than 12.5m and having an oxygen transmission of less than 25.1 cc/sq.m/24hr/atm.
Patent NZ-502698-A (NZ)
Title: Power adaption in a multi-station network
Inventor: LARSEN MARK SIEVERT
IPC: H04L12/00
Filed: 1998-08-03
Abstract: The method relates to the operation of a communication network,  the  network  comprising a plurality  of  stations that are able to transmit data to and receive data from  one another.  The method comprises monitoring, at each  station, the  transmission path quality between that station and each other station with which that station can communicate.  Data corresponding to the monitored path quality is  recorded  at each  station, thereby permitting a transmission power value based on the relevant path quality data to be selected  when transmitting data to another station. Thus, the  probability of  transmitting data to any selected station at an  optimum power  level  is  increased.  Each  station  transmits  path quality  data  in  its own transmissions as  well  as  local noise/interference data, so that other stations  can  obtain path quality data for a particular station even if they  are out  of  range  of  that particular station.  The  invention extends  to  communication apparatus that  can  be  used  to implement the method.
Patent NZ-506589-A (NZ)
Title: Microbicidal compositions and methods using synergistic combinations of propiconazole and 2-mercaptobenzothiazole
Inventor: PILLAY ALLAN
IPC: A01M29/12
Filed: 1999-03-05
Abstract: Microbicidal compositions containing synergistic combinations of propiconazole, (RS)- 1-2-[(2, 4-dichlorophenyl)-2- propyl-1,3-dioxanlan- 2ylmethyl]-1H-1,2, 4-triazole, and 2-mercaptobenzothiazole or alkali metal salt thereof are described. The propiconazole and 2-mercaptobenzothiazole or an alkali metal salt thereof are applied to a substrate or aqueous system subject to the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described. The combination of propiconazole and 2-mercaptobenzothiazole or an alkali metal salt thereof is particularly useful as microbicidal in the leather industry, the lumber industry, the papermaking industry, the textile industry, the agricultural industry, and the coating industry, as well as in industrial process waters.
Patent NZ-510622-A (NZ)
Title: Carbocyclic nucleoside salts
Inventor: WALLIS CHRISTOPHER JOHN
IPC: A61K31/535
Filed: 1998-05-14
Abstract: A dicarboxylate salt of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol wherein the dicarboxylate is selected from glutarate, hemisuberate, adipate, fumerate, hemisebacate and pimelate.
Patent NZ-512100-A (NZ)
Title: Crosslinked polymers and refractive devices formed therefrom
Inventor: MUIR ANDREW VICTOR GRAHAM
IPC: C08F222/36
Filed: 1999-12-13
Abstract: A  polymer that is formed of ethylenically unsaturated monomers  including  a  zwitterionic  monomer,  an  aromatic monomer   and   a   cross-linking  monomer   is   disclosed. Preferably  the crosslinking monomer includes at  least  one aromatic   group  containing  compound  and  at  least   one aliphatic  group containing compound. The polymer is  water- swellable   and  a  hydrogel  has  optical  and   mechanical properties  rendering it suitable for use as an  intraocular refractive device such as an intraocular lens.
Patent NZ-515062-A (NZ)
Title: New compounds, and pharmaceutically acceptable salts thereof, which inhibit basic carboxypeptidases
Inventor: LINSCHOTEN MARCEL
IPC: A61P43/00
Filed: 2000-05-03
Abstract: A compound of formula (I) where: R1 is C3-C7 cycloalkyl, substituted with one or more basic groups such as amino, amidino and or guanidine; aromatic heterocyclyl containing at least one nitrogen atom, and substituted with one or more basic groups such as amino, amidino and or guanidine; aliphatic heterocyclyl, containing at least one hetero atom selected from S or O, and substituted with one or more basic groups such as amino, amidino and or guanidine. R2 is H, C1-3 alkyl, amino, halogen, hydroxy; R3 is COOR5 R4 is SH, S-CO-C1-6 alkyl or S-CO-aryl; R5 is H, C1-6 alkyl or aryl; X is C(Z)2 Y is C(Z)2; Z is independently H, C1-6 alkyl or phenyl(C1-6 alkyl); where alkyl, cycloalkyl, aryl, alkylcarbamoyl, alkylthio, alkoxy, aroyl, aroylamino, aryloxy, arylthio, amidino, amino, aryl, carbamoyl, carboxy, cyano,cycloalkyl, formyl, guanidine, halogen, heterocyclyl, hydroxy, oxo, nitro, thiol, Z2N-CO-O-, ZO-CO-NZ or Z2CO-NZ. A process for the preparation of compounds of formula (I) is also disclosed. A pharmaceutical composition containing a compound of formula (I) for the inhibition of carboxypeptidase U. Also, a combined pharmaceutical composition comprising: a) a compound of formula (I), and b) one or more antithrombotic agent such as an antiplatelet agent, thromboxane receptor inhibitor, synthetase inhibitor, fibrinogen receptor antagonist, prostacyclin mimetic, phosphodiesterase inhibitor or ADP-receptor (P2T) antagonist.
Patent NZ-520981-A (NZ)
Title: 8,8a-dihydro-indeno[1,2-d]thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, a method for production thereof and use thereof as a medicament
Inventor: JAEHNE GERHARD
IPC: C07D277/60
Filed: 2001-02-13
Abstract: Polycyclic dihydrothiazole compounds of formula (I), the physiologically acceptable salts, the physiologically functional derivatives and methods for production thereof are disclosed, wherein the substituents are as defined in the specification. These compounds are suitable as, for example, anorectics.
Patent NZ-525310-A (NZ)
Title: Genetic control of sex ratio in animal populations
Inventor: THRESHER RONALD
IPC: C12N15/09
Filed: 2001-10-09
Abstract: The disclosure provides a nucleic acid construct, which may be inserted into the genome of a target organism. The construct consists of a promoter that is activated during the sex-determining stage of embryonic development/or gametogenesis, and a blocker that inhibits expression of a gene critical for sex differentiation.
Patent NZ-531944-A (NZ)
Title: Synthesis of cyclosporin analogs
Inventor: NAICKER SELVARAJ
IPC: A61K9/00
Filed: 2002-10-17
Abstract: Isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISATX247, and derivatives thereof. Mixtures of ISATX247 isomers exhibit a combination of enhanced potency and reduced toxicity over the naturally occurring and presently known cyclosporins. ISATX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of stereoselectivity. Stereoselective pathways may utilize a Wittig reaction, or an organometallic reagent comprising inorganic elements such as boron, silicon, titanium, and lithium. The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture.
Patent NZ-532660-A (NZ)
Title: An electronic regulatory compliance system and method for a plurality of wastewater treatment system
Inventor: MCKINNEY JERRY L
IPC: G06Q10/06
Filed: 2002-11-01
Abstract: The present invention provides an electronic regulatory compliance system and method that permits a regulatory agency to efficiently and accurately monitor thousands of environmental equipment installations, such as homeowner wastewater treatment plants, for compliance with regulatory requirements. The environmental equipment installations may be installed at different locations, operating on different inspection schedules, with different service companies, different owners, of different types, and be of a different processing capacity. A personnel detector is preferably utilized to verify the actual physical presence of service personnel. In accord with the invention, each environmental equipment system is connected to a network that logs and time-stamps events that occurs at each of the plurality of environmental equipment systems related to compliance with environmental regulations. In a preferred embodiment, a website is generated that permits a regulatory body to quickly view all accounts in noncompliance and automatically generate suitable notices of non-compliance for transmission to responsible parties.
Patent NZ-533084-A (NZ)
Title: Cell culture process
Inventor: BOGNER FRANZ-MARKUS
IPC: C12N15/09
Filed: 2002-11-26
Abstract: A method for producing a recombinant polypeptide of interest is described to comprise the following steps: (a) providing a transformed eukaryotic host cell which comprises a nucleotide sequence which encodes the recombinant polypeptide of interest and which directs expression of the recombinant polypeptide of interest and which directs expression of the recombinant polypeptide of interest in the host cell; (b) providing a serum-free culture medium which comprises (i) water, a plant-derived peptone, an osmolality regulator, a buffer, an energy source, amino acids, a lipid source or precursor, a source of iron, non-ferrous metal ions and one or more vitamins and cofactors; and (ii) does not contain any full-length polypeptides; and (c) culturing the transformed eukaryotic host cell in the culture medium under conditions that allow for expression of the recombinant polypeptide of interest.
Patent NZ-533966-A (NZ)
Title: 6-Aminomorphinane derivatives, method for their production and use in the treatment of pain
Inventor: SCHUTZ JOHANNES
IPC: A61P21/00
Filed: 2002-12-16
Abstract: A compound of the formula (I) is described, and its use for the treatment of pain, intestinal disease, rheumatic disease, cancer and withdrawal from drug addiction. The definitions of R1, R2, R3, R4, R5 and R6 are disclosed. The nitrogen joined with R1 can also be quarternised by two substituents R1 which can be the same or different, and whereby the second, quarternised substituent can additionally have the meaning hydroxyl, oxyl (N oxide) as well as alkoxyl; X is oxygen; and Y is oxygen or the group (Y-R4) is H.