baber/WOPTO huggingface dataset:
Patent EP-4147054-A1 (EP)
Inventor: BARNES MICHAEL
IPC: G16H30/00
Filed: 2021-05-05
Abstract: Methods and systems for predictive measures of anti-EGFR therapy response in wild type RAS/EGFR+ samples, e.g., histochemical staining methods for staining EGFR, AREG, and EREG, digital analysis of stained slides, and scoring algorithms that allow prediction of a response to anti-EGFR therapies. Analysis of the stained slides and scoring algorithms may include but are not limited to: a percent tumor cell positivity, computerized clustering algorithms, area density (e.g., area of tumor positive for one or more markers over total tumor area), average intensity (e.g., computerized methodology measuring average gray scale pixel intensity), average intensity broken down according to membrane, cytoplasmic, or punctate staining patterns), or any other appropriate parameter or combination of parameters. The methods of the present invention allow for resolving spatial expression patterns of the ligands and the receptor to determine what patterns are predictive for response to anti-EGFR therapies.
Patent EP-4165210-A1 (EP)
Title: Systèmes et procédés faradiques pour l'insertion autolimitée de pores de protéines dans une membrane
Inventor: BARRALL GOEFFREY
IPC: B01L3/00
Filed: 2021-06-08
Abstract: L'invention concerne des systèmes et des procédés permettant d'insérer un pore unique (316) dans une membrane (314) dans des conditions faradiques. Une forme d'onde de tension en rampe ou échelonnée peut être appliquée à travers les membranes des cellules d'un réseau, la forme d'onde de tension commençant à une première tension et augmentant en amplitude sur une période de temps jusqu'à une seconde tension. La forme d'onde de tension a une polarité qui maintient une première espèce d'un couple redox (308) dans son état d'oxydation courant. La première tension est sélectionnée pour être suffisamment basse pour réduire le risque d'endommagement de la membrane, tandis que la vitesse d'augmentation de la tension est sélectionnée pour fournir un temps suffisant pour que les pores s'insèrent dans les membranes. Une fois qu'un pore est inséré dans la membrane, la tension à travers la membrane chute rapidement, réduisant ainsi le risque d'endommagement de la membrane même si la tension appliquée entre les électrodes est encore accrue.
Patent EP-4157294-A1 (EP)
Inventor: DIAS ANDREW
IPC: C12N5/0793
Filed: 2021-05-28
Abstract: Provided herein is a dual cell aggregate culture of retinal epithelial cells and photoreceptors for use as a research tool, such as the screening of compounds or model for study of retinal diseases, as well as a therapeutic for treating ocular diseases.
Patent EP-4090112-A1 (EP)
Title: Pdcch configuration method and terminal
Inventor: LI GEN
IPC: H04W72/04
Filed: 2021-01-04
Abstract: Provided are a PDCCH configuration method and a terminal. The PDCCH configuration method comprises: receiving a PDCCH search space configuration, wherein the PDCCH search space configuration is associated with M control resource sets coresets and N time domain monitoring positions; forming L PDCCH search subspaces on the basis of the M coresets and the N time domain monitoring positions, wherein one PDCCH search subspace comprises one coreset and one time domain monitoring position; and receiving a PDCCH on the L PDCCH search subspaces, wherein M and N are both integers greater than or equal to one, and L is an integer greater than one.
Patent EP-4171455-A1 (EP)
Inventor: MUNNO FERDINANDO
IPC: A61F9/007
Filed: 2021-06-21
Abstract: This invention concerns the field of ophthalmic surgical instruments used in cataract operations. The invention consists, in particular, to a surgical instrument designed to incorporate the nucleus's crystalline lens and extract it entirely off the eye. The found consists of a tubular handle rotatable, that operates to a insertion mechanism, to which is connected to an intermediate element from which they take place, through two channels:a cable together joined a collection chamber, adapted to incorporate the nucleus's crystalline lens; a cursor, suitable for the hermetic closure of the collection chamber and a fixing device, used to weaken the internal fibers of the nucleus. The found allows the elimination of the phase of fragmentation and aspiration of the nucleus's crystalline lens with the integral removal of the nucleus avoiding micro-injuries or damage to the capsular bag used by ultrasound in the fragmentation phase and the consequent serious intraoperative complications.
Patent EP-4096478-A1 (EP)
Inventor: CORDOBA RODRIGO
IPC: A21B5/03
Filed: 2021-01-21
Abstract: An automatic apparatus for baking pastry products, wherein baking molds containing a pastry mass to be baked are introduced into the apparatus for baking purposes, wherein the apparatus comprises a reception or cooling module that defines a pre-chamber, a baking module, and a rotary oven door arranged between said modules so as to rotate for positioning the molds between reception, baking and cooling positions, thus avoiding the use of additional mechanical parts that may generate failures and inconveniences in the normal operation of the appliance, while the invented apparatus provides a better quality baked product that is achieved by homogeneous heating within the oven module.
Patent EP-4176420-A1 (EP)
Inventor: SERVAL THOMAS
IPC: E03C1/05
Filed: 2021-07-06
Abstract: A method includes (i) receiving data associated with an individual, the individual having hands; (ii) determining, from the received data, that the individual is washing the hands; and (iii) generating a response to be communicated to the individual based at least in part on the determination that the individual is washing the hands.
Patent EP-4188768-A1 (EP)
Title: Driving assistance system and driving assistance method for a vehicle
Inventor: BERGWEILER TOBIAS
IPC: B60W50/029
Filed: 2021-07-27
Abstract: The present disclosure relates to a driving assistance system for a vehicle. The driving assistance system comprises: - a first control unit and a second control unit, the second control unit being configured to receive instructions from the first control unit to carry out an action; and - at least one first sensor unit which is assigned to the first control unit. The second control unit is configured to carry out the action and to transmit information relating to the carrying out of the action to the first control unit. Furthermore, the first control unit is configured to check the plausibility of the information received from the second control unit on the basis of sensor data of the at least one first sensor unit.
Patent EP-4100301-A1 (EP)
Inventor: WESTBERG BJÖRN
IPC: B62D55/26
Filed: 2021-01-25
Abstract: The present invention relates to a ground engaging device (G) for an endless track (E) of a tracked vehicle. The ground engaging device is attachable to the outer side of said endless track (E). The ground engaging device (G) comprises an engagement member (10) configured to be arranged in connection to the outer side (Ea) of the endless track (E). The ground engaging device (G) further comprises a fastening arrangement (A) for attaching the ground engaging device (G) to the endless track (E) so that the engagement member (10) is positioned in connection the outer side (Ea) of the endless track (E). The fastening arrangement (A) comprises a adjustment device (D) configured to allow self adjustment of the position of said engagement member relative to the endless track (E) based on pressure against the engagement member (10) towards the endless track (E). The present invention also relates to a tracked vehicle.
Patent EP-4092360-A1 (EP)
Title: Air-conditioning system
Inventor: SUZUKI SHUUICHI
IPC: F25B49/02
Filed: 2021-01-22
Abstract: An air conditioner (10) has a refrigerant circuit (10a) in which a refrigerant circulates and a controller (33), and is configured to condition air in an indoor space (A). A countermeasure device (60, 65) is provided against leakage of the refrigerant to the indoor space (A). A detector (70) is configured to detect a concentration of the refrigerant in the indoor space (A). A first relay (811, 812) is connected to the controller (33) and the countermeasure device (60, 65). The controller (33) closes the first relay (811, 812) when the concentration of the refrigerant detected by the detector (70) exceeds a predetermined allowable concentration. The countermeasure device (60, 65) operates when the first relay (811, 812) is closed.
Patent EP-4182746-A1 (EP)
Inventor: HEANUE JOHN
IPC: H01S5/02216
Filed: 2021-07-14
Abstract: In part, in one aspect, the disclosure relates to a system including a photonic integrated circuit (PIC) assembly, comprising a PIC comprising: a first bond pad disposed inward from an edge of the PIC a first distance; and a first wire having a first length, the first wire electrically connected to the first bond pad and extending therefrom, wherein the first distance is greater than 0.4 mm.
Patent EP-4200396-A1 (EP)
Inventor: REINBIGLER RENE
IPC: G16B5/00
Filed: 2021-08-19
Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network
Patent EP-4116413-A1 (EP)
Title: Composition for regulating stem cell function comprising lactobacillus sp. bacteria-derived extracellular vesicles as active ingredient
Inventor: KIM YOON-KEUN
IPC: C12R1/225
Filed: 2021-02-26
Abstract: The present invention relates to a composition for regulating stem cell function comprising the genus Lactobacillus bacteria-derived extracellular vesicles as an active ingredient, and a method for regulating a stem cell function using the same. The genus Lactobacillus bacterial-derived extracellular vesicles, according the present invention, have the effect of greatly improving the proliferation of stem cells, and the extracellular vesicles are naturally secreted from a symbiotic the genus Lactobacillus strain in human tonsillar tissue and are human-friendly and natural substances, and thus can be used in various research fields by promoting the proliferation of aged stem cells with minimal toxicity and side effects.
Patent EP-4204476-A1 (EP)
Inventor: DAM MATHEUS ADRIANUS
IPC: C08G63/88
Filed: 2021-08-27
Abstract: Process for preparing a polyester comprising 2,5-furandicarboxylate units, which process comprises subjecting a starting composition comprising 2,5-furandicarboxylic acid and an aliphatic diol to esterification conditions to produce an ester composition and contacting the ester composition with a germanium containing solution at polycondensation conditions to produce a polyester comprising 2,5-furandicarboxylate units, and polyester comprising 2,5-furandicarboxylate units comprising of from 5 to 100 ppm of germanium and having a number average molecular weight of at least 30 kg/mol.
Patent EP-4121359-A1 (EP)
Inventor: FEDORKA THOMAS
IPC: B67D1/00
Filed: 2021-03-19
Abstract: Described herein is a nozzle for controlling foam of a carbonated beverage product produced by a beverage making machine, and associated system and method of use thereof. The nozzle can include an engagement portion configured for releasable attachment with the beverage making machine. The nozzle can further include a funnel portion extending elongated from the engagement portion and that is configured to converge a flow of the carbonated beverage product. The nozzle can further include a dispense portion to establish a stream of the carbonated beverage product into a receptacle. An alignment feature on an exterior of the nozzle can define an offset between a wall of the receptacle and the stream of the carbonated beverage product.
Patent EP-4213759-A1 (EP)
Inventor: JOHNSON MARK THOMAS
IPC: A61C17/22
Filed: 2021-09-09
Abstract: An oral care system for sensing blood in an oral cavity and in gum tissue. The sensing is performed magnetically using a magnetic field source (16) and magnetic sensing arrangement (18) incorporated into a cleaning or treatment portion of an oral care device (e.g. a brush head of a toothbrush or mouthpiece part of a brushing mouthpiece device). The field source generates (16) a reference field and the sensing arrangement (18) is arranged to sense the field strength of the reference field at one or more spatial points. Since blood is magnetic, when brought into the reference field, it magnetically interacts with the field, which may alter field strength, field shape, or flux distribution. This enables presence of blood to be detected. It also allows for detecting specific oral features or disease states associated with presence of blood or abnormal amounts or concentrations of blood. For example, this can be based on application of detection criteria which relate to one or more properties of the sensed field.
Patent EP-4211256-A1 (EP)
Inventor: KNAPE MATTHIAS JOSEPH
IPC: C12Q1/54
Filed: 2021-09-06
Abstract: La présente invention concerne un procédé de détection d'une activité lipase contaminante dans un échantillon d'une protéine recombinante par mesure de l'hydrolyse d'un substrat comprenant le chromophore 4-méthylumbelliféryl (4-MU) sous la forme d'un ester de 4-MU, l'ester de 4-MU étant un ester de 4 MU d'acide gras à chaîne non ramifiée saturé (C6-C16). L'invention concerne en outre un kit permettant de déterminer l'activité lipase contaminante dans un échantillon d'une protéine recombinante.
Patent EP-4232069-A1 (EP)
Inventor: FERRARA STEFANO
IPC: A61K38/20
Filed: 2021-10-26
Abstract: The present invention relates to an interleukin-2/interleukin-15 receptor βү (IL-2/IL- 15Rβү) agonist for use in the treatment of squamous cell carcinoma. Further provided are dosing schemes for treating patients with squamous cell carcinoma with an IL-2/IL- 15Rβү agonist.
Patent EP-4144472-A1 (EP)
Inventor: LEE JUNG JOON
IPC: B23K15/00
Filed: 2021-04-21
Abstract: The present invention relates to a ceramic cutting method and equipment, which is provided with a configuration comprising: a beam irradiation unit for irradiating a beam of a wavelength that is absorbed by a pattern formed on an upper surface of a ceramic and partially absorbed by the ceramic; a coolant spraying unit for spraying a coolant onto the ceramic irradiated with the beam, wherein part or all of the pattern is removed by heating and cooling the ceramic at the same time, and is cut by reducing thermal damage by using the stress caused by the recrystallization of an upper layer or all of the ceramic or the stress generated by the thermal expansion and contraction of the upper layer or all of the ceramic, thereby recrystallizing the ceramic by heating and cooling the ceramic at the same time, or cutting the ceramic by heating until the ceramic melts, and cooling to apply thermal stress to the inside of the ceramic, followed by an additional separation process of a ceramic material without loss.
Patent EP-4150120-A1 (EP)
Inventor: IP NANCY YUK-YU
IPC: C12Q1/6883
Filed: 2021-05-12
Abstract: The present invention provides protein markers present in a person's blood sample (such as a plasma, serum, or whole blood sample) that are associated with the Alzheimer's Disease (AD), diagnostic and treatment methods for AD, and kits for diagnosing AD.
Patent EP-4260017-A1 (EP)
Inventor: DASGUPTA SUBHASHISH
IPC: G01F1/58
Filed: 2021-10-06
Abstract: The present disclosure provides method and system (200) for operating Electromagnetic (EM) flowmeter (100) for improving measurements during flow distortion in flow pipe (109). The EM flowmeter (100) includes pair of coils (101, 103) powered by currents for generating electromagnetic fields, and pair of electrodes (105, 107) for measuring electromotive forces generated by interaction of electromagnetic and flow fields in fluid. To improve measurements during flow distortion, system (200) configures current in pair of coils (C1, C2) (101, 103) based on relation between distance of EM flowmeter (100) from flow distorting feature in flow pipe (109) and characteristic length of EM flowmeter (100). Further, based on configuration of current in pair of coils (C1, C2) (101, 103), signals generated due to electromotive forces are measured. Consequently, based on measured signals, flowrate of fluid is estimated in flow pipe (109).
Patent EP-4240491-A1 (EP)
Title: Cd19 binding molecules and uses thereof
Inventor: CEBE REGIS
IPC: A61P35/02
Filed: 2021-11-04
Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.
Patent EP-4126618-A1 (EP)
Inventor: MCPEEK-BECHTOLD NOLAN
IPC: B60W10/18
Filed: 2021-05-13
Abstract: Aspects of the disclosure provide for a method of controlling a vehicle (100) in an autonomous driving mode. For instance, the method may include receiving, by one or more processors of a brake controller (230) of the vehicle, a braking profile for a trajectory for the vehicle to follow into the future. The brake controller may determine whether to use one or both of regenerative and friction braking based on the braking profile. The vehicle is controlled according to the braking profile based on the determination of whether to use one or both of regenerative and friction braking.
Patent EP-4263461-A1 (EP)
Inventor: WEIDMANN JÜRG
IPC: C04B24/26
Filed: 2021-12-02
Abstract: The present invention relates to a process for the reduction of the content of a compound I of general formula (II) where R1 is hydrogen or methyl, each R2, independently from each other, is hydrogen or methyl, R3 is hydrogen or an aliphatic or cycloaliphatic or aromatic hydrocarbon with 1 – 8 carbon atoms, AO is a C2 – C12 oxyalkylene group, x = 0 or 1, and n = 2 – 350, from a mixture comprising or consisting of a compound I of general formula (II) and an alkoxylated alcohol A of general formula (I) where R1, R2, R3, AO, x, and n are as described in general formula (II) above, characterized in that said process comprises a treatment of said mixture comprising or consisting of a compound I and an alkoxylated alcohol A with an acid. The present invention also relates to the use of such alkoxylated alcohols A for the production of polycarboxylate ethers.
Patent EP-4255866-A1 (EP)
Inventor: PEGADO LUIS
IPC: C04B28/02
Filed: 2021-11-30
Abstract: The present invention relates to a process for the production of backfilling pastes for underground operations, said process comprising or essentially consisting of the mixing of a) cement, b) tailings from underground operations, c) optionally extra water, d) at least one polycarboxylate ether, and e) calcium hydroxide. The present invention also relates to a method for controlling the flow of a backfilling paste for underground operations, said method comprising at least one step of admixing an admixture comprising at least one polycarboxylate ether and calcium hydroxide to a mixture of cement, tailings, and water.
Patent EP-4256130-A1 (EP)
Inventor: HIETANIEMI MATTI
IPC: D21H17/26
Filed: 2021-12-01
Abstract: The invention relates to a chemical treatment system for manufacture of paper,board or the like and to a method employing it. The system comprises a firstcomponent, which is a glyoxylated polyacrylamide having a net cationic charge5density and obtained by glyoxylation of a cationic polyacrylamide base polymerhaving a weight average molecular weight MW in a range of 30 000 – 500 000 g/mol.The system further comprises a second component, which comprises a mixture ofat least a high-amylopectin starch, and an anionic first polymer, which has a weightaverage molecular weight MW >200 000 g/mol. The second component has a net0cationic charge density in a range from 0.05 meq/g to 0.9 meq/g, when measuredat pH 2.8, and a net anionic charge density in a range from -2 meq/g to -0.1 meq/g,when measured at pH 7.
Patent EP-4092809-A1 (EP)
Inventor: NAM HO CHOL
IPC: H01M10/48
Filed: 2021-06-11
Abstract: The present invention relates to a battery cell surface temperature estimation system and method, and more particularly, to a battery cell surface temperature estimation system and method capable of minimizing a temperature measurement delay through a software algorithm method that estimates the current actual cell surface temperature by reflecting the gradient of the measured temperature change of the battery cell.
Patent EP-4172669-A1 (EP)
Inventor: BHARGAVA PAVAN
IPC: H04J14/06
Filed: 2021-06-22
Abstract: A polarization splitter and rotator (PSR) is implemented within various electro-optic receiver, transmitter, and combiner devices to transform incoming light having two polarizations that are uncharacterized and/or time-varying into light of a single polarization for processing. The single-polarization light is either detected in the receiver embodiment or modulated in the transmitter embodiment. Multiple ring resonators are used to facilitate detection and/or modulation of the single-polarization light, where each ring resonator optically couples to one or more optical waveguides that extend from PSR outputs. In some transmitter embodiments, polarization-rotated light output by the PSR is polarization-derotated after modulation by a reverse-connected PSR. In some receiver embodiments, polarization-rotated light and polarization-non-rotated light (having the same polarization) is output from the PSR into a same optical waveguide in opposite directions for coupling into one or more photodetectors. Linear photodetectors separately detect light corresponding to different polarizations in the incoming light signal.
Patent EP-4171513-A1 (EP)
Title: Compositions for controlling odor and itch and methods of and devices for administering same
Inventor: FAULKNER MARK C
IPC: A61K31/69
Filed: 2021-06-30
Abstract: Compositions, such as aqueous solutions and non-aqueous solutions and slurries, of a weak acid are provided. The disclosed compositions may be used to treat, prevent, and/or reduce one or more symptoms associated with numerous vaginal conditions or disturbances, such as odor and itch.
Patent EP-4262375-A1 (EP)
Inventor: SLADE GLEN JONATHAN
IPC: A01K67/033
Filed: 2021-12-14
Abstract: An apparatus (1) with a container (2) for containing insects, a receiving member (200) upon which an insect in the container can lay an egg and an actuator (10) for removing the receiving member from the container once an egg has been laid upon the receiving member. The apparatus is for removing individual insect eggs from a container which contains many live insects. The individual eggs, once removed from the container, may be used in an individualized rearing process.
Patent EP-4179510-A1 (EP)
Inventor: MILLER JUSTIN
IPC: G08B21/12
Filed: 2021-07-06
Abstract: Apparatus and Methods for Aggregated Leak Detection. The method comprises determining the location of multiple portable personal gas detectors as each gas detector is moved and monitoring the gas level associated with each determined location. This information is then collated by associating the transmitted location and associated gas levels. Zones of concern associated with elevated gas levels detected by multiple gas detectors are then identified.