baber/WOPTO huggingface dataset:
Patent FI-964897-A0 (FI)
Inventor: PERREGAARD JENS KRISTIAN
IPC: C07D211/22
Filed: 1996-12-05
Abstract: The present invention relates to a series of 4-phenylpiperazines of formula (I)  wherein A is alkylene, alkenylene, alkynylene, and C3-7 cycloalkylene; R1 is a C3-10 alkyl, alkenyl, or alkynyl group, cycloalk(en)yl, cycloalk(en)yl-alk(en/yn)yl, trifluoromethylsulfonyl, or alkylsulfonyl, R2-R5 are optional substituents; R9 and R10 are hydrogen, alkyl or together form an ethylene or propylene bridge, W is O or S; V is O, S, CR6R7, or NR8 wherein R6, R7, and R8 are hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted arylalkyl or aryl, or R6 and R7 constitute a 3-7 membered spiro ring; Z is-(CH2)m-; m being 2 or 3 or Z is -CH=CH-; which show effects on central serotonin 5-HT1A and dopamine D2 receptors. Thus the novel compounds are useful in the treatment of certain psychic and neurologic disorders, in particular psychosis.
Patent FI-965014-A0 (FI)
Inventor: HAEGGLUND TJELL-AOKE
IPC: D21B1/12
Filed: 1996-12-13
Abstract: PCT No. PCT/SE95/00670 Sec. 371 Date Dec. 13, 1996 Sec. 102(e) Date Dec. 13, 1996 PCT Filed Jun. 7, 1995 PCT Pub. No. WO95/34711 PCT Pub. Date Dec. 21, 1995A chemimechanical pulp for use in the manufacture of paper or paperboard products where a high drainability, bulky pulp is desired. The pulp has a long fiber content of between 60 and 75%, a fine-material content of at most 14%, a shive content of less than 0.5%, is refined to a freeness of 600 ml CSF at the lowest, and has a tensile index of at least 10 kNm/kg. A method for producing such a pulp comprises: a) impregnating chips with a lignin softening chemical; b) preheating the chips; c) refining the chips to papermaking pulp; wherein the chips are impregnated and heated over a total time period of at most 4 minutes; a) using a hot impregnating liquid having a temperature of at least 130 DEG  C.; b) preheating the chips at a temperature above the lignin softening temperature; c) refining the pulp in one or more stages, of which the first or sole stage is carried out solely at essentially the same pressure and the same temperature as the preheating process; and refining the pulp at a total energy input which is at least 50% and at most 90% of the energy input required to achieve the same shive content when preheating at 135 DEG  C. and using the same machine equipment.
Patent FI-970771-A0 (FI)
Inventor: BURKHOLDER TIMOTHY PAUL
IPC: C07D401/06
Filed: 1997-02-24
Abstract: The present invention relates to novel substituted piperidine derivatives of the formulastereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.
Patent FI-972418-A0 (FI)
Inventor: DUNCAN CAROLYN B
IPC: C10M105/40
Filed: 1997-06-06
Abstract: A biodegradable lubricant which is prepared from: about 60-99% by weight of at least one biodegradable synthetic ester base stock which comprises the reaction product of: a branched or linear alcohol having the general formula R(OH)n, wherein R is an aliphatic or cyclo-aliphatic group having from about 2 to 20 carbon atoms and n is at least 2; and mixed acids comprising about 30 to 80 molar % of a linear acid having a carbon number in the range between about C5 to C12, and about 20 to 70 molar % of at least one branched acid having a carbon number number in the range between about C5 to C13; wherein the ester base stock exhibits the following properties: at least 60% biodegradation in 28 days as measured by the Modified Sturm test; a pour point of less than -25 DEG  C; and a viscosity of less than 7500 cps at -25 DEG  C; about 1 to 20% by weight lubricant additive package; and about 0 to 20% of a solvent.
Patent FI-990109-A0 (FI)
Inventor: HAUTOJAERVI JONI
IPC: D01F6/06
Filed: 1999-01-20
Abstract: The object of the present invention is a method for producing hydrophobic polymer fiber filaments, the method comprising the following steps     forming a melt from a hydrophobic polymer,   melt-spinning the polymer to form filaments,   applying a spin finish to the filaments, and optionally crimping and cutting the filaments into staple fibers. According to the invention, the method includes a step of subjecting the filament to at least one surface treatment step, preferably using a corona discharge or plasma treatment to increase the surface free energy thereof. An object of the invention is also an apparatus or production line for carrying out the method.   <IMAGE>
Patent IL-64890-A0 (IL)
Title: Alkanolamine derivatives
IPC: A61P25/02
Filed: 1982-01-28
Abstract: Novel alkanolamine derivatives of the formula: ArOCH2.CHOH.CH2NHA1NHCO  +TR <IMAGE>  wherein Ar is phenyl or naphthyl which is unsubstituted or which bears one or two substituents selected from halogen, trifluoromethyl, hydroxy, amino, nitro, carbamoyl, carbamoylmethyl and cyano, and alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, alkanoyl and alkanoylamino each of up to 6 carbon atoms, or Ar is 4-indolyl, 4-benzo[b]thienyl, 5-benzo[1,4]dioxanyl, 4- or 5-indanyl, 5- or 6- 1,2,3,4-tetrahydronaphthyl), 2,3-dihydroxy-1,2,3,4-tetrahydronaphth-5-yl or 4- morpholino-1,2,5-thiadiazol-3-yl; wherein R is halogen; wherein A1 is alkylene of 2 to 6 carbon atoms; and wherein A2 is alkylene of 1 to 7 carbon atoms which in unsubstituted or bears a phenyl, hydroxy or carbamoyl substituent, or A2 is cycloalkylene of 3 to 6 carbon atoms; or acid-addition salts thereof. The compounds possess either  beta -adrenergic blocking activity or diuretic activity or both such activities and may be used in the treatment of heart disease or hypertension. Also disclosed are processes for the manufacture of the compounds and pharmaceutical compositions containing them.
Patent IL-70863-A0 (IL)
Title: Production of benzofuran derivatives
IPC: B01J31/38
Filed: 1984-02-03
Abstract: A process for the production of benzofuran derivatives having the general formula,  <IMAGE>  wherein R is alkyl, in particular of 2,3-dihydro-2,2-dimethyl benzofuran-7-ol, starting from pyrocatechol ethers in one step operation. The process essentially consists of heating a solution of pyrocatechol ether in an inert organic solvent in the presence of a catalyst comprising metals of 3 DEG  and 4 DEG group of the Periodic System in form of carboxylates or of modified zeolites. The products are known intermediates for the production of insecticides.
Patent IL-85026-A0 (IL)
Title: Serum-free growth medium and use thereof
IPC: C12N5/10
Filed: 1988-01-05
Abstract: A serum-free growth medium additive comprising an iron chelate, aurintricarboxylic acid and optionally alkali metal-EDTA and trace elements together with possible growth factors, wherein the iron-chelate may comprise a mixture of FE-EDTA and citric acid. The growth medium may be used for quality testing of other growth media. A hybridoma cell line from P3U1 tumor cells and B-lymphocytes is also disclosed, and this cell line may optionally be used together with the growth medium additive when testing full growth media.
Patent AU-PO182996-A0 (AU)
Title: Absorbent material
IPC: C09K3/32
Filed: 1996-08-22
Abstract: PCT No. PCT/AU97/00535 Sec. 371 Date May 24, 1999 Sec. 102(e) Date May 24, 1999 PCT Filed Aug. 21, 1997 PCT Pub. No. WO98/07804 PCT Pub. Date Feb. 26, 1998A fire retardant absorbent material including coir fibres and/or coir dust, an effective quantity of a fire retardant material in the form of small particles, the particle size of the fire retardant material being of the order of less than 1 micron to ensure that the fire retardant material substantially penetrates or substantially coats at least a substantial proportion of the coir fibres present in the absorbent material.
Patent FI-20055442-A0 (FI)
Inventor: KORHONEN JOUNI
IPC: H04L29/08
Filed: 2005-08-22
Abstract: A method of providing an authentication/authorisation of a remote client terminal (100) in a network comprising an operator gateway (108) and an operator authentication server (110), and an external gateway (112) and an external authentication (114) server, wherein a mutual authentication protocol is agreed between said authentication servers. A secured tunnel is established between the client terminal and the operator gateway using an encryption key exchange protocol, and the client terminal is authenticated and authorised in the operator authentication server. A second authentication/authorisation procedure is initiated from the client terminal towards the external authentication server using the secured tunnel. The operator gateway transforms at least one message involved in the second authentication/authorisation procedure to be in accordance with the mutual authentication protocol, and the client terminal is authenticated and authorised in the external authentication server.
Patent IL-100086-A0 (IL)
Title: Retroviral protease inhibitors
IPC: A61K31/34
Filed: 1991-11-19
Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Patent IL-100450-A0 (IL)
Title: Pharmaceutical compositions containing fused dihydropyridines
IPC: A61K31/437
Filed: 1991-12-20
Abstract: 3,4-Dihydro-6,7-dimethoxy -1-(alpha-(bis(2-(2,3,4- trimethoxyphenyl)ethyl) -carbamoyl)benzyl)isoquinoline of formula (Ia) and its salts are new. Fused-ring dihydropyridine derivs. of formula (II) and their tautomers, salts and complexes are used as cerebroprotective agents, agents for treating chronic inflammatory disorders, and anticoagulants: X = OR1, NHR2 or NR3R4; R1 = H, 1-4C alkyl or 2-4C alkoxyalkyl; R2 = (a) e.g. H, 3-6C alkenyl, or (b) e.g. 1-6C alkyl opt. substd. by e.g. halogen, CN, OH, SH, 1-4C alkoxy; R3 and R4 = 1-4C alkyl opt. substd. by Ar2 or NR3R4 is a satd. or partially satd. opt. substd. 5- or 6-membered ring, opt. contg. up to two further heteroatoms (N, O and/or S): Ar1, Ar2 and R5 = phenyl opt. substd. by e.g. halogen, 1-4C alkoxy; Het = indolyl or 5- or 6-membered opt. substd. heterocyclyl contg. 1-3 heteroatoms (N, O and/or S); A = a gp. of formula A1-A4;: R5 is e.g. H, 1-4C alkyl; R6 and R7 is H, OH or R6+R7 = O(CH2)nO; R9 = H or 1-4C alkyl; R10 = H or 2-phenyl-2-ethoxycarbonylacetyl. Cpds. (I), other than (Ia), are described in EP 37934 and 251194.
Patent IL-109533-A0 (IL)
Title: Intermediates and methods for the synthesis of anthrapyrazolone anticancer compositions
IPC: C07D231/54
Filed: 1994-05-03
Abstract: This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.
Patent IL-119805-A0 (IL)
Title: Passive velocity data system
IPC: F42C17/04
Filed: 1996-12-10
Abstract: There is provided a velocity measuring system contained on-board a projectile (18). The velocity is determined by a microprocessor on-board said projectile (18) that bases the computation on a measurement of the time required for the projectile (18) to pass two fixed points (20, 21) along a gun barrel (12). The fixed points (20, 21) may be passive signal sources that do not require an external power supply. A high degree of velocity accuracy is achieved because the microprocessor calculation need not be completed during the time that the projectile (18) traverses the gun barrel (12). <IMAGE>
Patent IL-127711-A0 (IL)
Title: Device for the intraocular transfer of active products by iontophoresis
IPC: A61F9/007
Filed: 1998-12-23
Abstract: The instrument for the transfer of an active ingredient e.g. a medication into the eyeball, by iontophoresis, has a reservoir (15) for the medication which can be applied to the patient's eye. The reservoir has at least one active surface electrode (11) opposite an ocular tissue, at the periphery of the cornea (C). It also has a return electrode (12) and an electrical current generator. The return electrode is preferably in contact with the patient's closed eyelids (22,24). The reservoir has a number of compartments as ring segments, for different medications, each with its own active electrode.
Patent IL-139459-A0 (IL)
Title: Method and apparatus for signal processing in a satellite positioning system
IPC: G01S19/25
Filed: 1999-04-13
Abstract: A method and apparatus for processing satellite positioning system (SPS) signals which are weak in level. In one embodiment, a SPS receiver receives at least two signal samples representing, at least in part, common information, wherein the two signal samples are associated with one or more satellite messages. By combining the two signal samples, navigation information (e.g., time, position, velocity, etc.) may be determined based on the combination of the two signal samples. According to another embodiment, the two signal samples are differentially demodulated and summed together to form the combination.
Patent IL-140604-A0 (IL)
Title: Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
IPC: A61L31/00
Filed: 1999-07-06
Abstract: <CHEM> <??>An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R = NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, hyterocyclic series, OH, O-, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4 = H, SO3-, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocylic series, -CO- (CH2)2-COOY; Y= negative charge, or H; R5 = -CO-CH3, H, SO3-, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6= is H or a aliphatic, aromatic, arylaliphatic , cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7 = is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.
Patent IL-148874-A0 (IL)
Title: Sulfonyl amino acid derivatives, their preparation and pharmaceutical compositions containing them
IPC: A61P25/28
Filed: 2000-09-28
Abstract: The present invention is related to sulfonyl amino acid derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl amino acid derivatives. Said sulfonyl amino acid are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 33. The present invention is furthermore related to novel sulfonyl amino acid derivatives as well as to methods of their preparation.
Patent IL-148925-A0 (IL)
Title: Personal information security and exchange tool
IPC: G06Q20/10
Filed: 1997-07-22
Abstract: Utilization of the E-Metro Community and Personal Information Agents assure an effective and comprehensive agent-rule based command and control of informational assets in a networked computer environment. The concerns of informational privacy and informational self-determination are addressed squarely by the invention affording persons and entities a trusted means to author, secure, search, process, and exchange personal and/or confidential information in a networked computer environment. The formation of trusted electronic communities wherein members command and control their digital persona, exchanging or brokering for value the trusted utility of their informational assets is made possible by the invention. The present invention provides for the trusted utilization of personal data in electronic markets, providing both communities and individuals aggregate and individual rule-based control of the processing of their personal data.
Patent IL-155854-A0 (IL)
Title: Fire extinguishing methods utilizing hydrofluoroethers
IPC: C07C41/06
Filed: 2001-11-14
Abstract: Highly fluorinated, saturated and unsaturated hydrofluoroethers are efficient, economical, non-ozone-depleting fire extinguishing agents used alone or in blends with other fire extinguishing agents in total flooding and portable systems.
Patent IL-166309-A0 (IL)
Title: Preparation of 1h-imidazoÄ4,5-cÜquinolin-4-amines via 1h-imidazoÄ4,5-cÜquinolin-4-phthalimide intermediates
IPC: C07D471/04
Filed: 2005-01-14
Abstract: The invention provides 1H-imidazo (4,5-c) quinoline-4-phthalimide intermediates useful in the synthesis of 1H-imidazo (4,5-c) quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo (4,5-c) quinoline-4-amines via the intermediates.
Patent IL-173846-A0 (IL)
Title: Method of treating cancer with hdal inhibitors
IPC: A61K31/16
Filed: 2006-02-21
Abstract: The present invention relates to methods of treating cancers, e.g., mesothelioma or lymphoma. More specifically, the present invention relates to methods of treating mesothelioma or diffuse large B-cell lymphoma (DLBCL), by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors  in vivo.
Patent IL-192153-A0 (IL)
Title: Process for manufacturing entacapone
Filed: 2008-06-12
Abstract: New processes for manufacturing entacapone are provided.
Patent IL-192377-A0 (IL)
Title: Treatment of renal disorders, diabetic nephopathy and dyslipidemias
Filed: 2008-06-22
Abstract: Disclosed herein are methods, compounds and compositions for preventing or treating a renal disorder or chronic kidney diseases, including nephropathies such as diabetic nephropathy. The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for the prevention and/or treatment of for preventing or treating a renal disorder complication. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in diabetic patients.
Patent RO-126506-A0 (RO)
Title: Clock-work
Inventor: NAGY CSABA ŞANDOR
IPC: G04B13/02
Filed: 2011-02-08
Abstract: The invention relates to a clock-work meant to be used either in mechanical or electro-mechanical clocks or wrist watches or pendulum clocks. According to the invention, the mechanism comprises an electric motor () having an axle () which transmits the motion to a transparent gear wheel (), representing the minute wheel, mounted on an arbor () integral with another transparent driving gear wheel () which engages with a transparent satellite gear wheel (), representing the hour wheel, guided on an internal toothing () of a body () of a clock.
Patent RO-129752-A0 (RO)
Title: Device and method for automatically monitoring a location
Inventor: BUDIŞTEANU IONUŢ ALEXANDRU
IPC: G06K9/36
Filed: 2014-03-14
Abstract: The invention relates to a device and a method meant to provide the automatic detection of some frames containing information, whose processing should be done in a relatively short period of time, to be used inside an enclosure in a commercial bank, commercial space or the like. According to the invention, the device comprises a monitoring camera () of a pretty good quality, whose optical infrared filter was removed and of a relatively high resolution, which is connected through the communication port IC or USB port to a microprocessor (), a GPS () with SiRF 3 or NMEA connection protocol, a Flash/NVRAM memory () of minimum 1 GB and a connection () to internet/secured private network/GPRS, in order to transmit the warning to a specialized center. As claimed by the invention, the method consists in following the stages I...XVI, where the images of interest are selected and processed, so that, if the imposed conditions are met, a warning is generated, said warning comprising the confidence level and the sequence of the suspicious frames, afterwards there are started the image analyzes made by a human person, for confirmation and for taking the required measures.
Patent ZW-9391-A1 (ZW)
Title: Continuous release pharmaceutical compositions
Inventor: ROGER CAMBLE
IPC: A61K47/48
Filed: 1991-07-15
Abstract: Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer. The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient.   <IMAGE>
Patent CH-715712-A1 (CH)
Title: Verschlusskappe zum Verschliessen eines Behälters und Behälter mit einer solchen unverlierbar gehaltenen Verschlusskappe.
Inventor: ERWIN MAYER
IPC: B65D55/16
Filed: 2019-01-07
Abstract: Die Erfindung betrifft eine Verschlusskappe (11) zum Verschliessen der Ausgiessöffnung eines Behälters, aufweisend einen zylindrischen Gewindeteil (15) mit einem offenen Rand (27) und einem Innengewinde, welches mit einem Aussengewinde eines Behälterhalses des Behälters zusammenwirken kann, ein Garantieband (17), welches dazu ausgebildet ist an einem an dem Behälterhals ausgeformten Vorsprung gehalten zu sein und eine Haltevorrichtung (19,21) mit einem ersten und einem zweiten Ende , wobei das erste Ende mit dem offenen Rand (27) des Gewindeteils (15) fest verbunden ist und das zweite Ende mit dem Garantieband (17) fest verbunden ist. Die Haltevorrichtung weist ein erstes und ein zweites Halteband (19,21) auf, wobei das erste und das zweite Halteband (19,21) aus einer ersten Position, in welcher ersten Position sie innerhalb des Garantiebandes (17) angeordnet sind, in eine zweite Position ausziehbar sind, in welcher sie ausserhalb des Garantiebandes (17) angeordnet sind.
Patent IE-910606-A1 (IE)
Title: Carbapenem derivatives having antibiotic activity, their¹preparation and their use
IPC: A61K31/495
Filed: 1991-02-22
Abstract: Carbapenem compounds of formula (I): [in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R<1 > is hydrogen or methyl; R<2> is hydrogen or alkyl; R<3> is hydrogen or a negative ion; Q is: (i) -B-N<+>R<8>R<9>R<1><0>, where R<8>, R<9> and R<10 > are alkenyl, alkynyl or optionally substituted alkyl, and B is alkylene or alkylidene; (ii) a heterocyclic group of which one ring atom is a >N<+>R<1><1>R<1><2>, where R<1><1> and R<1><2> are alkenyl, alkynyl or optionally substituted alkyl; (iii) alkyl substituted by a heterocyclic group as defined in (ii) above; or (iv) alkyl substituted by an aromatic heterocyclic group, of which one ring atom is or R<2> and Q, and the nitrogen to which they are attached, form a group of formula (II): where m and n are 1, 2 or 3; R<6> is optionally substituted alkyl; and R<7> is alkenyl, alkynyl or optionally substituted alkyl] and pharmaceutically acceptable salts and esters thereof have valuable antibacterial activity with enhanced resistance to dehydropeptidase I and beta -lactamase. Methods of preparing and using the compounds are also provided.