Patent GB-572368-A (GB)
Title: Improved antiseptic preparations
IPC: A01N31/08
Filed: 1943-10-13
Abstract: An antiseptic comprises a dispersion of an aryl (including aralkyl) dihydroxy-benzene or an aryl (including aralkyl) chlorhydroxy-benzene in an aqueous medium containing as a dispersing agent a water-soluble salt of an alkyl sulphate or sulphonate in which the alkyl group contains at least eight carbon atoms.  The pH of the dispersion should preferably lie between 6.0 and 9.0, say about 7.5.  Suitable benzene derivatives include dichlor-dihydroxy-diphenylmethanes, dichlor-dimethyl-dihydroxy-diphenyl ethanes, dichlor-dimethyl-dihydroxy-diphenylchlormethanes, dichlor - dimethyl - dihydroxy - diphenyl - trichlorethanes, dichlor - dihydroxy - diphenyl - trichlorethanes and dimethyl -di - hydroxy - diphenyl - trichlorethanes.  Preferred dispersing agents include alkyl sodium sulphates prepared by the sulphation of long chain olefins, a mixture of the sodium salts of sulphated primary aliphatic alcohols mainly cetyl alcohol, or the sodium salts of sulphonated petroleum residues. The dispersions may be compounded with other materials such as aliphatic alcohols containing at least eight carbon atoms, cholesterol, or vitaminized fatty oils or waxes.  According to examples: (1) a ,a -(3.31-dichlor-4.41 - dihydroxy - diphenyl) - ethane was mixed with "Lanette" was (Registered Trade Mark), an aqueous solution of sodium alkyl sulphates, and water; (2) a .a 1-(3.31-dichlor-6.61-dimethyl-4.41 -dihydroxy-diphenyl)-b .b .b -trichlor-ethane was mixed with high quality wax, an aqueous solution of the alkyl sulphates and water. The benzene derivative used in example 2 may be prepared by the reaction of chloral hydrate with p-chlor-o-cresol in the presence of glacial acetic and sulphuric acids at elevated temperature. The initial material used in example 1 may be similarly prepared from paraldehyde and o-chlor-phenol.  The Provisional Specification describes also the use of benzyl-chlorphenols-chlorcresols and chlorxylenols.ALSO:An antiseptic comprises a dispersion of an aryl (including arakyl) dihydroxy-benzene or an aryl (including arakyl) chlorhydroxy-benzene in an equeous medium containing as a dispersing agent a water-soluble salt of an alkyl sulphate or sulphonate in which the alkyl group contains at least eight carbon atoms.  The pH of the dispersion should preferably lie between 6.0 and 9.0, say about 7.5 Suitable benzene derivatives include dichlor-dihydroxy-diphenyl-methanes, dichlor-dimethyl-dihydroxy-diphenyl ethanes, dichlor-dimethyl-dihydroxy-diphenyl-chlormethanes, dichlor - dimethyl - dihydroxy - diphenyl - trichlorethanes, dichor - dihydroxy-diphenyl - trichlorethanes and dimethyl-dihydroxy-diphenyl-trichlorethanes. Preferred dispersing agents include alkyl sodium sulphates prepared by the sulphation of long chain olefins, a mixture of the sodium salts of sulphated primary aliphatic alcohols mainly cetyl alcohol, or the sodium salts of sulphonated petroleum residues.  The dispersions may be compounded with other materials such as aliphatic alcohols containing at least eight carbon atoms, cholesterol, or vitaminised fatty oils or waxes.  According to examples, (1) a , a -(3.31-dichlor-4.41-dihydroxy-diphenyl)-ethane was mixed with "Lanette" wax (Registered Trade Mark), an aqueous solution of the sodium alkyl sulphates, and water; (2) a .a 1-3.31dichlor-6.61-dimethyl-4.41 -dihydroxy-diphenyl)-b .b .b -trichlor-ethine was mixed with high quality wax, an aqueous solution of the alkyl sulphates and water.  The benzene derivative used in example 2 may be prepared by the reaction of chloral hydrate with p-chlor-o-cresol in the presence of glacial acetic and sulphuric acids at elevated temperature.  The initial material used in example 1 may be similarly prepared from paraldehyde and o-chlor-phenol.  The Provisional Specification describes also the use of benzyl-chlorphenols, -chlorcresols and -chlorxylenols.