baber/WOPTO huggingface dataset:
Patent CA-2964941-A1 (CA)
Title: Procedes et compositions pour dosage en therapie cellulaire adoptive
Inventor: GILBERT MARK J
IPC: A61K39/00
Filed: 2015-10-20
Abstract: L'invention concerne des procédés pour l'administration de doses multiples de cellules, telle que des cellules T, à des sujets pour une thérapie cellulaire. L'invention porte également sur des compositions et des articles de fabrication, destinés à être utilisés dans les procédés. Les cellules expriment généralement des récepteurs recombinés tels que des récepteurs chimériques, par exemple, des récepteurs antigéniques chimériques (CAR) ou d'autres récepteurs transgéniques, tels que des récepteurs de cellules T (TCR). Les procédés consistent généralement à administrer une première dose et au moins une dose consécutive des cellules. Le rythme des doses les unes par rapport aux autres, et/ou la taille des doses, selon certains modes de réalisation procurent divers avantages, tels qu'une toxicité plus faible ou réduite et une meilleure efficacité, par exemple, en raison d'une augmentation de l'exposition du sujet aux cellules administrées. Selon certains modes de réalisation, la première dose est une dose relativement faible, telle qu'une dose qui réduit la charge tumorale ou pathologique, ce qui permet d'améliorer l'efficacité des doses consécutives ou ultérieures, et la dose consécutive est une dose de consolidation.
Patent CA-2965455-A1 (CA)
Inventor: REMONDINI MARCO
IPC: G01N1/24
Filed: 2015-11-03
Abstract: Described is an apparatus (1) for measuring odours comprising: a measuring chamber (2); an intake duct (4) having two ends, an inlet end (4a) in communication with the outside environment and an outlet end (4b) in connection with the measuring chamber; at least one sensor (3), positioned inside the measuring chamber (2) and designed for measuring the olfactory properties of a gas; a control unit (6) designed for processing signals coming from the at least one sensor (3) and providing a parameter representing the odours measured in the gas to be analysed; a suction device (5), positioned inside the intake duct (4) and designed to circulate the gas inside the apparatus (1); a cleaning device designed for restoring the characteristics of the at least one sensor (3) following a measurement, characterised in that the cleaning device is designed for generating ozone inside the apparatus (1).
Patent CA-2969486-A1 (CA)
Inventor: JUHL KARSTEN
IPC: A61K31/4439
Filed: 2015-11-09
Abstract: The present invention is directed to compounds of Formula (I) which are inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the reduction of ?ß deposits is beneficial such as Alzheimer's disease.
Patent CA-2969673-A1 (CA)
Inventor: MAC DONALD JOHN JOSEPH
IPC: F02D41/00
Filed: 2014-01-09
Abstract: An engine system and method for operating an internal combustion engine in dynamically varying conditions. An exemplary system comprises an internal combustion engine configured to receive both a primary fuel and a secondary fuel into one or more chambers in which a combustion process occurs, a fuel injection system, an air intake manifold and a fuel manifold; an electronic system which controls timing and metering of the primary fuel and/or the secondary fuel in the combustion process; and a plurality of sensors positioned to measure one or more variables associated with combustion of the primary fuel in the presence of the secondary fuel. The electronic system is configured to apply a control signal to adjust an engine setting to reduce NOx emissions based in part on the magnitude of the variable.
Patent CA-2969790-A1 (CA)
Inventor: COSENZA MARIA
IPC: A61P35/00
Filed: 2015-12-04
Abstract: The invention relates to pharmaceutical combinations comprising an HDAC inhibitor and bendamustine; pharmaceutical compositions comprising the same; and methods of using such combinations and compositions for treating lymphoma in a subject in need thereof.
Patent CA-2971295-A1 (CA)
Inventor: ECKERSALL PETER DAVID
IPC: G01N33/68
Filed: 2015-12-22
Abstract: The present invention relates to methods for determining pathological tissue damage in fish. Also the present invention relates to methods for diagnosing infectious disease in fish. In particular, the present invention is based on the surprising finding that mixing fish serum with an aqueous protein precipitation solution according to the present invention will result in a protein precipitation reaction if the fish is suffering from pathological tissue damage. Moreover it was surprisingly observed that the degree of turbidity of the precipitate in the mix of sample and aqueous protein precipitation solution was dependent on the state of infectious disease in fish.
Patent CA-2972482-A1 (CA)
Title: Device for accommodating surgical tool prior to and during medical procedures
Inventor: MURATORI ADAM
IPC: A61B90/00
Filed: 2016-01-14
Abstract: A device may be configured for white balancing a medical videoscopic camera system prior to videoscopic medical procedures, as well as optionally simultaneously or non-simultaneously applying a fog-prohibiting agent to the distal lens of a medical videoscope such as an endoscope or laparoscope. The device combines a white balancing mechanism, protective mechanism, and defogging mechanism in one simple easy to use device.
Patent CA-2976239-A1 (CA)
Inventor: FISCHER THOMAS
IPC: H04N21/431
Filed: 2017-08-15
Abstract: The invention concerns a method for navigating a focus element (18) for highlighting menu items (16) of a menu bar (12, 14) on a screen (4) by a deflection of an actuation device (28 to 31) on a remote control (6). The method comprises a detection of a first control signal (48) dependent on a degree of deflection of the actuation device (28 to 31) and a second control signal (62) dependent on an actuation force (62) with which the actuation device (28 to 31) is deflected. The method also comprises shifting the focus element (18) and menu items (16) relative to each other depending on a comparison (72) of the second control signal (62) and a predetermined condition (74), if the first control signal (48) is detected.
Patent CA-2977264-A1 (CA)
Inventor: GEVA MICHAL
IPC: A61K31/451
Filed: 2016-02-24
Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject. The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.
Patent CA-2977851-A1 (CA)
Inventor: ZHANG WEIXING
IPC: A61B17/88
Filed: 2016-04-30
Abstract: Disclosed is a Kirschner wire bending device, comprising a locating slot. The locating slot is used for fixing a Kirschner wire (80), one side of the locating slot is provided with a contact (3, 103) applying the bending force to the steel wire (80) fixed in the locating slot. Relative to the prior art, wherein a tong jaw is used, the steel wire (80) is usually firstly clamped, and then the steel wire (80) is forcibly bent in the clamped state, which are laborious and time-consuming. This application not only provides a device for bending and scraping the orthopaedic wire (80) to be broken once, which is suitable for cases where the steel wire (80) needs to be scraped to be broken; and further provides a device for only bending the steel wire (80). Since the force for bending the steel wire (80) is much smaller than the force for scraping it until same is broken, the low requirements for materials and low manufacturing cost thereof are suitable for cases where the orthopaedic steel wire (80) only needs to be bent.
Patent CA-2979361-A1 (CA)
Inventor: DOMENYUK VALERIY
IPC: C12N15/115
Filed: 2016-03-09
Abstract: Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases.
Patent CA-2979737-A1 (CA)
Title: Suction device, holding device, and conveyance method
Inventor: SHIMIZU TAKAYUKI
IPC: B25J15/06
Filed: 2016-07-01
Abstract: The present invention provides a suction hand part (310) which is attached to the leading-end section (330a) of a multi-joint arm, which suctions a plate-shaped structure member (200) having a curvature at least in a predetermined direction, and which is provided with: a support part (311) that is attached to the leading-end section (330a) of the multi-joint arm; a pair of suction mechanisms (312, 313), that have a pair of suction surfaces (312c, 313c), disposed apart from each other in an X direction over the attachment position (P1) of the support part (311) attached to the leading-end section (330a); and a pair of first angle adjustment mechanisms (314, 315) that are capable of adjusting the angle of inclination, in the X direction, of each of the suction surfaces (312c, 313c) of the pair of the suction mechanisms (312, 313).
Patent CA-2982356-A1 (CA)
Title: Verrouillage de securite de capture d'aiguille pour catheter
Inventor: STOKES JOHN
IPC: A61M25/06
Filed: 2016-04-15
Abstract: Est décrit un assemblage de cathéter qui comprend : un cathéter flexible ; une aiguille ayant une pointe distale pointue, l'aiguille étant placée dans le cathéter flexible et se déplaçant depuis une première position qui expose l'aiguille jusqu'à une seconde position ; un élément externe qui est configuré pour engager et désengager un raccord de cathéter ; un élément interne placé dans l'élément externe ; et un élément de protection d'aiguille pour protéger au moins une pointe distale de l'aiguille quand l'aiguille est dans la seconde position et quand l'aiguille est disposée à travers l'élément de protection d'aiguille dans la première position.
Patent CA-2982544-A1 (CA)
Title: Corrugated filtration media for polarizing air cleaner
Inventor: WISER FORWOOD C
IPC: B03C3/09
Filed: 2016-04-14
Abstract: A filter media includes flat sheets that are corrugated into a honeycomb matrix wherein air flows through the material and airborne contaminants are captured on the sidewalls of the material, wherein an active electrostatic field is applied to the flat sheets.
Patent CA-2985054-A1 (CA)
Title: Profondeur du mecanisme de reglage d'entrainement d'un mecanisme d'entrainement de ressort a gaz
Inventor: POMEROY EDWARD
IPC: B25C1/06
Filed: 2017-11-09
Abstract: Un mécanisme dentraînement de fixation comprend une première pièce de nez, et une deuxième pièce de nez couplée à la première avec un canal dentraînement de fixation formé entre les première et deuxième pièces de nez. Un élément de contact de pièce de travail est mobile par rapport aux première et deuxième pièces de nez entre une position sortie et une position rétractée. Un verrou à libération rapide fixe les première et deuxième pièces de nez ensemble. Lélément de contact de pièce de travail est positionné entre le verrou à libération rapide et la première pièce de nez.
Patent CA-2989473-A1 (CA)
Title: Progressive content development and management platform and associated methods
Inventor: AL SABAWI KHALED
IPC: H04N21/854
Filed: 2017-12-19
Abstract: An improved collaborative authoring system and method provides for management of complex collaborative works comprising sets of elements related to each other in a hierarchy. The collaborative work is defined as including a plurality of element sets. During a submission period, contributing users are permitted to submit proposed elements for a corresponding element set. Reviewing users, which may include contributing users, can concurrently submit feedback in response to the proposed elements that are submitted, and contributing users can modify proposed elements. At the end of the submission period, one or more of the proposed elements are selected for inclusion in the collaborative work. Multiple submission periods may occur for multiple element sets. The collaborative work can be used to generate an output file that can contain only a subset of the elements submitted during the submission periods.
Patent CA-2991370-A1 (CA)
Title: Chair for a chairlift
Inventor: SUTTERLUTY ANDREAS
IPC: B61B12/00
Filed: 2016-07-11
Abstract: A chair for chairlifts comprises at least one seat portion (4) that can pivot about an axis, and an elastic element (2) between the seat portion (4) and a frame (7) of the chair. An actuation mechanism that is connected to the seat portion (4) allows the seat portion (4) to pivot downward counter to the force of the elastic element (2) and lock the seat portion (4) in said position in order to make it easier for chairlift users to get on and off the chair.
Patent CA-2996580-A1 (CA)
Title: Composition pharmaceutique dermatologique adaptee aux oligonucleotides
Inventor: SCHMIDTS THOMAS
IPC: A61K47/02
Filed: 2011-02-11
Abstract: Linvention concerne une composition cosmétique et/ou dermatologique et/ou pharmaceutique destinée à lutilisation et à lapplication topiques doligonucléotides, notamment doligonucléotides antisens tels que des ADNzymes, des ARNsi, des ADNas ou des ribozymes pour une utilisation comme agents contre les maladies inflammatoires par émulsion avec une phase aqueuse dispersée, intérieure, discontinue.
Patent CA-2998966-A1 (CA)
Inventor: TIBERG FREDRIK
IPC: A61P1/08
Filed: 2016-09-16
Abstract: The present invention relates to an injectable pre-formulation comprising a low viscosity mixture of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one oxygen containing organic solvent; d) at least one 5HT3 antagonist; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. Such compositions may additionally comprise polar solvents and/or further active agents such as opioid agonists and/or antagonists. Methods of treatment, particularly for management of nausea and vomiting such as for post-operative nausea and vomiting and/or therapy induced nausea and vomiting are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.
Patent CA-3004539-A1 (CA)
Inventor: IWABUCHI YOSHIHIKO
IPC: F02P13/00
Filed: 2015-11-10
Abstract: The invention relates to a method for controlling an internal combustion engine, which is provided with a fuel injection valve which has a plurality of injection holes and injects fuel directly into a cylinder, and a spark plug which creates a plug discharge channel. A spark plug is placed between the spray paths of fuel injected from two adjacent injection holes, and is arranged so that a discharge area is positioned in a range in which an airflow disturbance occurs. After fuel injection is performed, the spark plug performs spark ignition while the airflow disturbance is being caused by the fuel injection.
Patent CA-3007092-A1 (CA)
Title: Fabrics containing expanded polytetrafluoroethylene fibers
Inventor: MINOR DAVID J
IPC: B32B5/02
Filed: 2016-12-14
Abstract: Woven and knit fabrics containing expanded polytetraflucroethylene (ePTFE) fibers and at least one other fiber are provided. The ePTFE fiber may be woven or knit as a single, non-twisted fiber, as part of a multifilament fiber, or may be twisted or braided with another fiber. The ePTFE fiber, whether alone or in combination with a weave fiber(s), may be utilized in either the warp and/or the weft direction. The woven and knit fabrics are concurrently breathable, lightweight, durable, drapable, and fast drying. The ePTFE fibers have a substantially rectangular configuration. In some embodiments, the woven or knit fabric is flame resistant, in addition, the woven and knit fabrics are quiet, soft, and drapable. Treatments may be provided to the surface of the ePTFE fiber and/or the fabrics to impart one or more desired functionality, such as, for example, oleophobicity, anti-microbial, contamination resistance, or UV stability.
Patent CA-3008848-A1 (CA)
Inventor: GLASS CHARLES
IPC: A61K31/737
Filed: 2016-12-16
Abstract: Disclosed herein are substantially pure glycosaminoglycan compositions derived from genetically modified cells.
Patent CA-3010827-A1 (CA)
Title: Therapeutique pour maladies immuno-inflammatoires oculaires
Inventor: DANA REZA
IPC: A61P27/04
Filed: 2017-01-06
Abstract: L'invention concerne des procédés et des compositions pour réduire l'activité ou le nombre de cellules mémoires Th17 dans le tissu oculaire et pour traiter et/ou prévenir des maladies immuno-inflammatoires oculaires.
Patent CA-3011007-A1 (CA)
Inventor: LESTINI FEDERICO
IPC: E04B1/348
Filed: 2016-12-23
Abstract: A modular building structure is disclosed. The modular building structure has a frame obtained by assembling a plurality of module frames. A plurality of connecting knots join module frames adjacent at corners and connect the module frames either to a flat basement or to a roof structure. Adjacent beams of side-by-side module frames and the respective panels are both spaced apart by said connecting knots, so as to create an air gap between adjacent panels of adjacent module frames. The ducts of said service plants are arranged in said air gaps between adjacent panels and in said passing-through channels and constrained to a respective module frame. Quick connections for connecting said ducts related to a module frame to ducts of another module frame placed side-by-side thereto are also provided.
Patent CA-3014639-A1 (CA)
Title: Biogenic silver nanoparticles for sers biosensing
Inventor: RAJPUT SUNIL
IPC: G01N33/483
Filed: 2018-08-17
Abstract: As described herein there is described biogenic silver nanoparticles for SERS  biosensing.
Patent CA-3015247-A1 (CA)
Inventor: SCHNIEDERS FRANK
IPC: C07K14/705
Filed: 2017-02-23
Abstract: The present disclosure provides a novel vector for immunostimulation and methods of using same in immunotherapy, in particular cancer immunotherapy. The novel vector comprises nucleic acid sequences encoding 4-1BB ligand (4-1BBL, CD137 ligand), single chain IL-12 (sc IL-12) and IL-2, wherein the vector provides for an increased expression of 4-1BBL as compared to the expression levels of sc IL-12 and IL-2. Specifically, the nucleic acid sequences encoding 4-1BBL, sc IL-12 and IL-2 are organized in the vector in 5' to 3' orientation in a sequential order 1, 2, 3, with the proviso that the gene encoding sc IL-12 is not at position 1.  Embodiments of the present disclosure include virus particles comprising the novel vector as well as cancer or immune cells transduced or transfected with the novel vector.
Patent CA-3016134-A1 (CA)
Inventor: ROLLI GIAN PAOLO
IPC: A23L19/00
Filed: 2016-03-08
Abstract: A method for preparing cut and frozen vegetables including the step of washing the vegetables in order to eliminate any residues of soil or other substances and materials that may have accumulated during picking. In a subsequent step, it is necessary to subject the vegetables to a mechanical treatment in order to isolate their edible part. One then proceeds by cutting the vegetables into granules with sizes comprised between 30 mm3 and 60 mm3 by using a cutting device. At this point, one proceeds by immersing the granules in water for a predefined limited time. At a later time, one proceeds by scalding, with jets of hot water, the granules and air drying them.
Patent CA-3017293-A1 (CA)
Inventor: ROSEN ROBERT
IPC: A61F2/16
Filed: 2017-03-10
Abstract: Lenses and methods are provided for improving peripheral and/or central vision for patients who suffer from certain retinal conditions that reduce central vision or patients who have undergone cataract surgery. The lens (100) is configured to improve vision by having an optic configured to focus light incident along a direction parallel to an optical axis (109) at the fovea in order to produce a functional foveal image. The optic is configured to focus light incident on the patient's eye at an oblique angle with respect to the optical axis at a peripheral retinal location disposed at a distance from the fovea, the peripheral retinal location having an eccentricity between -30 degrees and 30 degrees. The image quality at the peripheral retinal location is improved by reducing at least one optical aberration at the peripheral retinal location. The method for improving vision utilizes ocular measurements to iteratively adjust the shape factor of the lens to reduce peripheral refractive errors.
Patent CA-3017665-A1 (CA)
Inventor: VOLLE MICHAEL
IPC: A62B11/00
Filed: 2018-09-17
Abstract: A low-microbe / low particulate commercial portable air conditioner includes a housing, the housing having an ambient air entry grill, a cold air discharge grate, a condenser air inlet gill and a warm air discharge grill disposed therein. The low-microbe / low particulate commercial portable air conditioner also includes a plurality of wheels, the plurality of wheels affixed to the housing and an evaporator positioned within the housing. In addition, the low-microbe / low particulate commercial portable air conditioner has an evaporator chamber positioned within the housing and abutting the evaporator, the evaporator chamber in fluid communication with the ambient air entry grill and the cold air discharge grate, the evaporator chamber coated with smooth surface insulation, a condenser positioned within the housing, wherein the condenser and condenser air stream are isolated from the evaporator chamber and evaporator air stream.
Patent CA-3020418-A1 (CA)
Inventor: HOLLMEN MAIJA-LEENA
IPC: C07K16/28
Filed: 2017-04-18
Abstract: An agent capable of binding to CLEVER-1 in an individual can be used in activating macrophages to switch their phenotype from M2 macrophages into M1 macrophages. The invention relates to methods for utilizing the macrophages ability to switch their phenotype. In one aspect, the invention relates to a method for estimating of the efficacy of anti-CLEVER-1 therapy by monitoring a modulation of M2 macrophages into M1 macrophages, when an agent capable of binding to CLEVER-1 is administered in a patient, wherein an increased TNF-alpha secretion or HLA-DR expression is indicative of modulation of M2 macrophages into M1 macrophages.
Patent CA-3020997-A1 (CA)
Title: Distributed transaction propagation and verification system
Inventor: MICALI SILVIO
IPC: G06Q40/00
Filed: 2017-05-04
Abstract: In a transaction system in which transactions are organized in blocks, an entity to constructs a new block of valid transactions, relative to a sequence of prior blocks, by having the entity determine a quantity Q from the prior blocks, having the entity use a secret key in order to compute a string S uniquely associated to Q and the entity, having the entity compute from Q a quantity T that is S itself, a function of S, and/or hash value of S, having the entity determine whether T possesses a given property, and, if T possesses the given property, having the entity digitally sign the new block and make available S and a digitally signed version of the new block. The secret key may be a secret signing key corresponding to a public key of the entity. S may be a digital signature of Q by the entity.