baber/WOPTO huggingface dataset:
Patent WO-2023028558-A3 (WO)
Title: Procédé de fabrication d'agents induisant l'apoptose
Inventor: KU YI-YIN
IPC: C07C17/269
Filed: 2022-08-25
Abstract: L'invention concerne un procédé de préparation d'un agent induisant l'apoptose, ainsi que des intermédiaires chimiques de celui-ci. L'invention concerne également de nouveaux intermédiaires chimiques associés au procédé de l'invention.
Patent WO-2023150012-A3 (WO)
Inventor: LE LINH
IPC: A61B5/01
Filed: 2023-01-10
Abstract: L'invention concerne un procédé de prédiction de maladie du pied. Le procédé comprend la fourniture d'une première pluralité de capteurs de température positionnés par rapport à un premier ensemble d'emplacements sur le premier pied d'un patient et d'une seconde pluralité de capteurs de température positionnés par rapport à un second ensemble d'emplacements sur le second pied du patient, le second ensemble d'emplacements étant une image spéculaire du premier ensemble d'emplacements. Le procédé comprend ensuite la comparaison d'une température enregistrée à un premier instant par chaque capteur de la seconde pluralité de capteurs de température avec une température enregistrée au premier instant par le capteur correspondant de la première pluralité.
En cas d'identification d'une différence de température supérieure à un seuil de température de point chaud entre une première paire de capteurs correspondants, le procédé permet ensuite de définir un premier état de risque de point chaud.
Patent WO-2023239821-A3 (WO)
Title: Treating cancers with combinations of acylfulvenes with ibrutinib or bortezomib
Inventor: BHATIA KISHOR
IPC: A61P35/04
Filed: 2023-06-07
Abstract: A method of treating cancer includes a combination of a therapeutically effective amount of an illudin or an illudin analog thereof, derivative, or a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of Bortezomib, Ibrutinib or an analog, derivative, or a pharmaceutically acceptable salt thereof. Compositions and kits of the same are included herein. The cancer may be refractory to Bortezomib and/or Ibrutinib
Patent WO-2023168325-A3 (WO)
Title: Size-exclusion membrane for selective urea removal on kidney dialysis machine
Inventor: TANG RUNBANG
IPC: B01D69/08
Filed: 2023-03-02
Abstract: Methods of making membranes and membranes that have high urea selectivity. A flat sheet membrane selectively permeable to urea includes a polymer cast from a polymer solution into a thin membrane having a top and bottom surface; and macrovoids or microvoids extending from the top surface to the bottom surface of the membrane that allow the membrane to be selectively permeable to urea.
Patent WO-2023205689-A3 (WO)
Inventor: COLEMAN JOHN ROBERT
IPC: A61K39/12
Filed: 2023-04-19
Abstract: The present invention provides for compositions comprising deoptimized influenza viruses and methods of using the composition for the treatment of cancer. Wherein treating a malignant tumor, comprises: administering a deoptimized influenza virus to a subject in need thereof, wherein an HA protein of the deoptimized influenza virus is encoded by a nucleic acid having a specified sequence.
Patent EP-1194445-A4 (EP)
Title: Methods for protein purification using aqueous two-phase extraction
Inventor: HAYENGA KIRK J
IPC: C07K1/14
Filed: 2000-05-04
Abstract: Methods are provided in this invention for the isolation of human growth hormone, growth hormone antagonist, or a homologue of either, from a biological source. The methods of the invention use multi-phase extraction.
Patent EP-1186655-A4 (EP)
Title: Packaging cell
Inventor: KITAMURA TOSHIO
IPC: C12N7/02
Filed: 2000-06-01
Abstract: A virus-producing cell sustaining the ability to produce viruses at high titer is successfully constructed by expressing the virus structural gene under the regulation of EF1 alpha  promoter. In this virus-producing cell, the virus structural gene is ligated to a selection marker gene via IRES and domains other than the protein coding domain are eliminated from the DNA encoding virus structural proteins. Thus, reduction of the titer due to cell passages can be prevented and emergence of wild type viruses caused by unfavorable recombination of the virus genome can be inhibited.
Patent EP-1189511-A4 (EP)
Title: Liquid herbicide composition
Inventor: NAKAYAMA KAZUNARI
IPC: A01N25/30
Filed: 2000-06-21
Abstract: A novel liquid herbicide composition containing carfentrazone-ethyl, an anionic surfactant, a water-soluble organic compound and water and having a pH of from 2 to 7 is provided in which carfentrazone-ethyl is prevented from being degraded in storage.
Patent EP-1226153-A4 (EP)
Title: Fluorescent cobalamins and uses thereof
Inventor: GRISSOM CHARLES B
IPC: C07D487/22
Filed: 2000-10-26
Abstract: The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
Patent EP-1293083-A4 (EP)
Inventor: SPRINGER ARTHUR L
IPC: H04M17/00
Filed: 2000-12-18
Abstract: L'invention concerne un processus d'interception d'appel sur carte téléphonique, ou d'interception d'appel sur carte téléphonique entre une origine interne et un aboutissement international dans les pays où la fraude est importante. Le système comprend une unité de réponse automatique (ARU) (115), un opérateur de premier niveau (125) et un opérateur de second niveau (165). En outre, si l'appelant réussit la vérification, une trace détaillée est établie et enregistrée dans un processus d'interception d'appel d'ordinateur principal (99) qui annule automatiquement toute interception future d'appel.
Patent EP-1263752-A4 (EP)
Title: Lpa receptor agonists and antagonists and methods of use
Inventor: MILLER DUANE D
IPC: A61P17/02
Filed: 2001-03-19
Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors: such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
Patent EP-1271832-A4 (EP)
Inventor: UESUGI MITSURU
IPC: H04W4/00
Filed: 2001-05-18
Abstract: Dans un dispositif côté-réception (150), une unité de mesure (157) de qualité de réception, mesure la qualité de la réception de données, une unité de détection d'erreurs (156) détecte, le cas échéant, une erreur de réception de données, une unité de création de trames de transmission (158) réalise le multiplexage d'un signal de demande de retransmission et d'un signal de qualité de réception de données de transmission lorsqu'une erreur est détectée et envoie les données de transmission. Lorsqu'un dispositif côté-transmission (100) reçoit le signal de demande de retransmission, une unité de programmation (110) mesure la capacité nécessaire au dispositif côté-réception (150) pour démoduler les données, à partir du signal de qualité de réception, et transmet à nouveau les données avec la capacité nécessaire. Ainsi, le nombre de retransmissions de données entre la transmission et la réception peut être réduit afin d'améliorer l'efficacité de la transmission.
Patent EP-1318080-A4 (EP)
Title: Adhesive wrap film
Inventor: ITADA MITSUYOSHI
IPC: C09J7/30
Filed: 2001-09-03
Abstract: An adhesive wrapping film having a continuous tackifier layer (A) on at least one side surface of a substrate layer (B) whose surface has a concavo-convex form, wherein a thickness of the tackifier layer at the concave portion of the substrate layer is larger than that at the convex portion of the substrate layer, and a thickness of the substrate layer BAV, a thickness of the tackifier layer at the concave portion of the substrate layer Amax, a ten-point average roughness of the surface of the tackifier layer corresponding to a height of the convex portion of the tackifier layer RZ<(A)>, and a ten-point average roughness of the surface of the substrate layer corresponding to a height of the convex portion of the substrate layer RZ<(B) >satisfy a relation of the following conditional expressions (1) and (2):(1) Amax<RZ<(B)><BAV(2) RZ<(A)><RZ<(B)>.
Patent EP-1328511-A4 (EP)
Title: Substituted (e)-styryl benzylsulfones for treating proliferative disorders
Inventor: REDDY E PREMKUMAR
IPC: C07C317/18
Filed: 2001-10-05
Abstract: (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R<SUB>1 </SUB>is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R<SUB>2 </SUB>and R<SUB>3 </SUB>are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxyl, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R<SUB>1 </SUB>may not be halogen when R<SUB>2 </SUB>and R<SUB>3 </SUB>are both halogen; R<SUB>2 </SUB>may not be 2-halogen when R<SUB>3 </SUB>is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: wherein: R<SUB>4 </SUB>is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R<SUB>6 </SUB>is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R<SUB>7 </SUB>is selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, dimethylamino (C2-C6 alkoxy) and trifluoromethyl; provided R<SUB>5 </SUB>and R<SUB>6 </SUB>may not be hydrogen in the same compound; or a pharmaceutically acceptable salt thereof.
Patent EP-1340748-A4 (EP)
Title: Quinazoline derivatives and drugs
Inventor: OKANO MASAHIKO
IPC: A61P25/04
Filed: 2001-11-01
Abstract: The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster. The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof: <CHEM> wherein R<1> represents a hydrogen atom or alkyl; A<1> and A<2> are the same or different and each represents a single bond or a divalent aliphatic hydrocarbon group; Q represents a single bond, cycloalkylene group, phenylene group or a divalent heterocyclic group; R<2A> and R<2B> are the same or different and each represents a hydrogen atom or alkyl; R<3> represents an optionally substituted phenyl group or heterocyclic group; R<4> and R<5> are the same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, -NR<6>R<7> and the like.
Patent EP-1342727-A4 (EP)
Inventor: KAGEYAMA TSUTOMU
IPC: C12P21/08
Filed: 2001-11-15
Abstract: La présente invention concerne des antigènes immunogènes contenant des peptides antigéniques spécifiques contre le virus Norwalk qui sont sélectionnés parmi les séquences d'acides aminés représentées par les SEQ ID NOS: 1 à 4 et un anticorps spécifique contre le virus Norwalk dirigé contre ces antigènes immunogènes qui sont tous construits. La détection d'un virus à l'aide de cet anticorps à spécificité virale permet de détecter de manière commode et précise le virus Norwalk.
Patent EP-1361528-A4 (EP)
Inventor: NATSUNO TAKESHI
IPC: G06Q50/00
Filed: 2002-02-06
Abstract: Selon la présente invention, un appelant peut facilement appeler à n"importe quel moment ou de n"importe quel endroit et un répondeur peut être enregistré en tant que tel, en peu de temps et sans occasionner de problèmes. Un appareil d"un centre de médiation accepte l"enregistrement d"un répondeur à partir d"un téléphone mobile (9) du répondeur et fournit, en réponse à une demande émanant d"un téléphone mobile (10) d"un appelant, une information afférente aux listes de candidats répondeurs adéquats sélectionnés parmi les répondeurs enregistrés dans l"appareil du centre de médiation (1). Si ledit appareil (1) reçoit une information d"instruction visant à sélectionner une réponse du téléphone mobile (10), cet appareil (1) établit un circuit entre le téléphone mobile (9) du répondeur sélectionné et le téléphone mobile (10) de l"appelant. Ainsi, on obtient des questions et des réponses entre un appelant et un répondeur, et donc un service de médiation de consultation.
Patent EP-1379089-A4 (EP)
Title: Image encoding method and apparatus, image decoding method and apparatus, and image processing system
Inventor: SEKIGUCHI SHUNICHI
IPC: H04N19/423
Filed: 2002-04-08
Abstract: A method and an apparatus for using the pattern matching technique, so as to express encoded data in a compact manner, thereby improving the encoding efficiency. A waveform vector similar to a partial signal waveform of an image signal is sought. When compressing/encoding information identifying the found waveform vector, similarity information expressing the similarity degree, and the in-image position of the partial signal waveform, the in-image position of the partial signal waveform is replaced by position information of the image signal in a predetermined partial region. Thus, the in-image position of the partial signal waveform most similar to the waveform vector is encoded by replacing it with the position information of the image signal in the predetermined partial region. Accordingly, it is possible to express the position in a compact manner.
Patent EP-1430776-A4 (EP)
Inventor: MITO NOBUAKI
IPC: A01N43/84
Filed: 2002-04-26
Abstract: La présente invention concerne une composition herbicide comprenant un composé d'uracile de formule générale (I), dans laquelle : Z est halogéno ou cyano ; A est oxygène, soufre, ou NH ; R1 est hydroxyle, alcoxy en C1-C7, alcényloxy en C3-C7, alcynyloxy en C3-C7, ou analogues ; et R2 est hydrogène ou méthyle, et au moins un composé choisi parmi le groupe constitué de N-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2H-1,4-benz-oxazin-6-yl)cyclohex-1-ène-1,2-dicarboximide et N-[2,4-dichloro-5-[4-(difluorométhyl)-4,5-dihydro-3-méthyl-5-oxo-1H-1,2,4-triazol-1-yl]phényl]méthanesulfonamide. L'invention concerne également un procédé de désherbage comportant l'application d'une dose efficace de la composition herbicide aux mauvaises herbes. Selon l'invention, on peut efficacement éliminer les mauvaises herbes notamment dans des vergers, des champs de soja et des terres non cultivées.
Patent EP-1400240-A4 (EP)
Title: Percutaneously absorbable patches
Inventor: TAKADA Y
IPC: A61P29/00
Filed: 2002-05-02
Abstract: It is intended to provide percutaneously absorbable patches having an improved percutaneous absorbability of an anti-inflammatory agent in the form of a salt and an improved stability. Namely, percutaneously absorbable patches having an adhesive base layer which contains an anti-inflammatory agent in the form of a salt, an ammonium salt compound, an absorption enhancer and/or a solubilizer.
Patent EP-1518955-A4 (EP)
Title: Textile product decoloring device and decoloring method
Inventor: TASHIRO TAKEHISA
IPC: D06L3/00
Filed: 2002-05-17
Abstract: The present invention provides an apparatus suitable for decolorizing a textile product using ozone. The apparatus of the present invention enables the decolorization rate to be adjusted by adjusting the water content of the textile product and controlling the ozone concentration to achieve uniform decolorization. The decolorization apparatus for a textile product of the present invention includes an airtight container 1, a rotary drum 2 which rotates in the airtight container, an ozone generator 41 connected with the airtight container 1 through an automatic valve 42, a water supply unit 58, and a blower unit 34 which includes an air heater 31 and supplies hot air and cool air to the airtight container 1. The ozone concentration inside the airtight container is maintained at a desired level by measuring the ozone concentration using an ozone analyzer 43 and controlling the ozone generator 41. <IMAGE>
Patent EP-1440605-A4 (EP)
Inventor: THE BODINE COMPANY INC
IPC: H05B41/14
Filed: 2002-03-15
Abstract: L'invention concerne une alimentation électrique supplémentaire permettant de maintenir le courant d'arc dans une lampe (L) à décharge à haute intensité (DHI) et conçue pour appliquer une tension d'arc supplémentaire à haute fréquence, afin de maintenir l'arc pendant une période d'alimentation CA instable ou discontinue, en plus ou en remplacement de la tension ou du courant fourni(e) à la lampe par le ballast (12) DHI. L'instabilité de l'alimentation CA est identifiée en moins de temps qu'il ne faut à cette alimentation instable ou discontinue pour entraîner l'extinction de l'arc de la lampe et alimenter une alimentation électrique supplémentaire permettant de maintenir l'arc de la lampe pendant la période d'instabilité ou d'interruption, tant que sa batterie interne rechargeable est opérationnelle. Un système de surveillance (18) détecte le rétablissement d'une alimentation en courant électrique répétitive stable (sous la forme d'un cycle se répétant continuellement et pas nécessairement d'une alimentation CA sinusoïdale) qui présente alors un niveau d'énergie suffisant pour maintenir en fonctionnement la lampe DHI.
Patent EP-1487620-A4 (EP)
Title: Fiber cutting mechanism
Inventor: HAWLEY RONALD
IPC: B29C48/38
Filed: 2002-08-20
Abstract: A cutting mechanism for cutting fibers entrained within a viscous flow is herein disclosed. The present invention is typically part of a system for preparing fiber reinforced molding materials that comprises a viscous entrainment compounding device for compounding a continuous strand of reinforcing fiber with a molding material in a predetermined ratio. The entrained fibers are conveyed to the cutting mechanism which cuts the continuous strand of reinforcing fibers into predetermined lengths and conveys the fiber reinforced molding material to an output device. The cutting mechanism itself comprises a housing having a bore with an inlet and an outlet and a bed knife disposed therein. The bed knife has an inlet channel formed therethrough that is aligned with the gullets of a rotating cutter such that the gullets of the rotating cutter are rotated past the inlet channel of the bed knife in substantial alignment therewith. Fibers entrained within the molding material flow into the gullets of the rotating cutter and are cut to a predetermined length and then conveyed to an output device.
Patent EP-1481692-A4 (EP)
Title: Sterilizer
Inventor: HASEGAWA HITOSHI
IPC: A61L2/06
Filed: 2002-09-05
Abstract: A sterilizer comprising a chamber (2) for containing an article being sterilized, and a section (a work table (3), a fixing tool (14), and the like) for forming a space in which a work for containing the article in the chamber (2) under a specified state is performed and containable in the chamber (2).
Patent EP-1435863-A4 (EP)
Title: Transmural ablation tool and method
Inventor: PENDEKANTI RAJESH
IPC: A61B18/14
Filed: 2002-09-23
Abstract: An ablation method and device contacts one surface of a target layer and positions the tissue to ablate entirely through the layer. The tissue may be a wall of the heart (ablated, for example, to form blocking lesions for atrial fibrillation), and ablation may be performed with the heart stopped or beating, and effected by either endocardial or epicardial contact. Access may be through an open incision or a minimally invasive technique involving a small opening through which one or more elongated surgical tools are inserted. Illustratively, an atrial ablation treatment can be performed prophylactically (after CABG), or independently to treat an existing condition. A tool of the present invention has a handle at a proximal end, a bipolar ablation head, and an elongated body interconnecting the handle and the ablation head. A channel or contoured surface fixes and bends the tissue such that inter-electrode conduction paths span the thickness of the layer, thus dependably creating a fully transmural ablation lesion. The oriented transmural energy conduction paths reduce the possibility of inducing coagulation of blood in the heart chamber. One bipolar assembly has an electrode spacing of approximately ten millimeters across a channel of about five millimeters depth. Preferably the ablation head forms a suction holder, connected through internal passages to a vacuum pressure of about 100-500 mmHg, and immobilizes the contacted tissue.
Patent EP-1456343-A4 (EP)
Title: A process for the anaerobic treatment of flowable and nonflowable organic waste
Inventor: CUMMINGS ROBERT J
IPC: C02F11/04
Filed: 2002-09-18
Abstract: A method and apparatus for anaerobic treatment of organic wastes in a liquid filled vessel wherein particles of the waste are buoyed and form a floating bed in the liquid by the gasses generated by the anaerobic digestion of the wastes. The bed forms to an upper stratum of the least digested, least dense waste and a lower stratum of the most digested, most dense waste. Liquid from beneath the bed is continuously sprayed over the upper surface of the bed through a series of discharge ports which expands to bed downwardly. Each spraying period is followed by a quiescent period to allow the bed to reform. Over time the floating bed is moved from an inlet end to an outlet end of the vessel where the most digested waste is removed.
Patent EP-1433036-A4 (EP)
Inventor: PILLION JOHN E
IPC: F28D7/08
Filed: 2002-09-26
Abstract: La présente invention a trait à un appareil permettant de conditionner la température d'un fluide, au moyen d'un appareil d'échange de chaleur thermoplastique composé d'une pluralité de tubes creux. L'appareil régule la température d'un fluide de traitement contenu à l'intérieur de l'échangeur de chaleur, par le réglage d'une valve de commande régulant l'écoulement d'un fluide d'échange. L'appareil peut également être utilisé pour maintenir la température de bains chimiques, et pour préparer des volumes distribués discrets de liquide à température régulée. Le dispositif est chimiquement inerte, et peut fonctionner à des températures élevées et avec des liquides corrosifs et oxydants.
Patent EP-1461000-A4 (EP)
Inventor: ONYUKSEL HAYAT
IPC: A61K38/22
Filed: 2002-11-27
Abstract: L'invention porte sur des procédés de traitement de plusieurs maladies et troubles à l'aide de micelles, et des composés cristallins à stabilisation stérique de l'invention.