Patent SG-11201808708R-A (SG)
Title: Heterocyclic amides useful as protein modulators
Inventor: CHARNLEY ADAM KENNETH
IPC: C07D403/12
Filed: 2017-04-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property —, Organization MD 1111101110101011111 HO 11111 0111010111 101101110111111101111011# International Bureau ... ..... ..Yj ..... ....:2• (10) International Publication Number (43) International Publication Date WO 2017/175156 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 403/12 (2006.01) A61P 29/00 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 401/14 (2006.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/4184 (2006.01) A61P 37/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/IB2017/051962 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 5 April 2017 (05.04.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/319,355 7 April 2016 (07.04.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: GLAXOSMITHKLINE INTELLECTUAL TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, PROPERTY DEVELOPMENT LIMITED [GB/GB]; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 980 Great West Road, Brentford Middlesex TW89GS DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (GB). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: CHARNLEY, Adam Kenneth; 1250 South SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Collegeville Road, Collegeville, Pennsylvania 19426 (US). GW, KM, ML, MR, NE, SN, TD, TG). DARCY, Michael G.; 709 Swedeland Road, King of Prus- Declarations under Rule 4.17: sia, Pennsylvania 19406 (US). DODSON, Jason W.; 709 — as to applicant's entitlement to apply for and be granted a Swedeland Road, King of Prussia, Pennsylvania 19406 patent (Rule 4.17(ii)) (US). HUGHES, Terry V.; 1705 Glenn Lane, Blue Bell, Pennsylvania 19422 (US). LI, Yue; 709 Swedeland Road, — as to the applicant's entitlement to claim the priority of the King of Prussia, Pennsylvania 19406 (US). LIAN, Yiqian; earlier application (Rule 4.17(iii)) 1250 South Collegeville Road, Collegeville, Pennsylvania _ of inventorship (Rule 4.17(iv)) 19426 (US). NEVINS, Neysa; 1250 Collegeville Road, Collegeville, Pennsylvania 19426 (US). RAMANJULU, Published: Joshi M.; 1250 South Collegeville Road, Collegeville, with international search report (Art. 21(3)) Pennsylvania 19426 (US). (54) Title: HETEROCYCLIC AMIDES USEFUL R AS R 4 PROTEIN MODULATORS N R a R 1 / \ N N,, N R ,-1 ir) 11 ir) IN 11 IN 1-1 (57) : Disclosed are compounds having 0 or a salt, particularly a pharmaceutically acceptable salt, thereof. ei I ) \ 0 R8 R 3 the formula (I) wherein Ra, R I , R 2 , R 3 , R 4 , 1 (I) R 5 , R 6 , R 7 , and R 8 , are as defined herein, 0