baber/WOPTO huggingface dataset:
Patent DE-69811507-T2 (DE)
Inventor: ASSELIN ANDRE ALFRED
IPC: C07F9/645
Filed: 1998-07-31
Granted: 2003-07-24
Abstract: This invention relates to a process for the preparation of formula (I) compound [2-((8,9)-dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)ethyl]phosphonic acid, an NMDA antagonist useful as an anticonvulsant and neuroprotectant in situations involving excess release of excitatory amino acids. In the process of the present invention, 3-aminopropyl carbamic acid 1,1-dimethyl-ethyl ester is reacted with a dialkyl vinylphosphonate to obtain N-[3-(t-butyloxycarbonyl-amino)propyl]-2-aminoethylphosphonic acid dialkyl ester (d) in 80 % yield. Reaction of (d) with a 3,4-dialkoxycyclobut-3-en-1,2-dione gives [3-[[2-(dialkoxyphosphoryl)ethyl]-(2-alkoxy-3,4-dioxo-1,2-cyclobuten-1-yl)amino]propyl] carbamic acid 1,1-dimethylethyl ester (e) in 96 % yield. Deprotection and cyclization of (e) in trifluoroacetic acid gives [2-((8,9)-dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)ethyl]phosphonic acid dialkyl ester (c) in 58 % yield. The phosphonic acid diethyl ester (c) was treated with bromotrimethylsilane to give compound (I).
Patent DE-69819538-T2 (DE)
Inventor: CHEN YI
IPC: C07C213/10
Filed: 1998-09-01
Granted: 2004-09-30
Abstract: A process for enhancing the purity of 2R-[1-hydroxy- 1-trifluoromethyl- 3-cyclopropylpropyn-2-yl] -4-chloroaniline comprising the formation of an acid addition salt which is capable of rejecting the racemate in the selected organic solvent.
Patent DE-69825234-T2 (DE)
Inventor: WU YUEJIAN
IPC: G11C29/34
Filed: 1998-02-25
Granted: 2004-11-18
Abstract: A method for and apparatus of testing a multi-port RAM (random access memory) detect single port faults and inter port shorts in multi-port random access memories. The algorithm performs a conventional single-port test such as MARCH or SMARCH on one port of the memory and performs an inter-port test on all other ports. The algorithm does not impose any extra test time and requires the addition of only a few gates to a conventional single-port BIST controller, independently of the size of the memory. An address to select ports of the multi-port RAM includes a row address signal of a plurality of bits. A specific bit of the row address signal is changed.
Patent DE-69825728-T2 (DE)
Inventor: JANSSON KARI
IPC: C08G63/78
Filed: 1998-02-13
Granted: 2005-08-25
Abstract: A two-step process is described for the polymerization of lactide to polylactide, in which process in the first step polymerization is carried out to a conversion of at least 50% by weight, and in the latter step the polylactide is polymerized further to a high conversion in conditions in which the mixing of the melt and the evaporation of the lactide are avoided.
Patent DE-69832079-T2 (DE)
Inventor: TELFAIR B
IPC: H01S3/06
Filed: 1998-01-28
Granted: 2006-07-20
Abstract: A laser parametric generator for surgical applications is disclosed which utilizes short-pulse, mid-infrared radiation. The mid-infrared radiation may be produced by a pump laser source (20), such as a neodymium-doped laser, which is parametrically downconverted in a suitable nonlinear crystal (15) to the desired mid-infrared range. The short pulses reduce unwanted thermal effects and changes in adjacent to potentially submicron levels. The parametrically converted radiation source preferably produces pulse durations shorter than 25 ns at or near 3.0  mu m but preferably close to the water absorption maximum associated with the tissue. The down-conversion to the desired mid-infrared wavelength is preferably produced by a nonlinear crystal (15) such as KTP or its isomorphs. In one embodiment, a non-critically phased-matched crystal is utilized to shift the wavelength from a near-infrared laser source emitting at or around 880 to 900 nm to the desired 2.9 to 3.0  mu m wavelength range. A fiber, fiber bundle or another waveguide means utilized to separate the pump laser from the optical parametric oscillation (OPO) cavity is also included as part of the invention.
Patent DE-69834615-T2 (DE)
Inventor: COUDERCHON GEORGES
IPC: H01F1/153
Filed: 1998-11-13
Granted: 2007-04-26
Abstract: Production of a nanocrystalline soft magnetic iron-silicon-boron alloy magnetic core involves crystallization heat treatment of the amorphous alloy at 150-400 degrees C in a transverse magnetic field of rectangular waveform. Production of a magnetic core of nanocrystalline soft magnetic alloy, containing more than 60 at.% Fe, 10-20 at.% Si, 0.1-2 at.% Cu, 5-20 at.% B and 0.1-10 at.% of one or more of Ti, Nb, Zr, Hf, V, Ta, Cr, Mo, W and Mn, the sum of Si + B being less than 30 at.%, involves crystallization heat treatment of the amorphous alloy to obtain a core having a maximum impedance magnetic permeability ( mu z) with a value of 350000 at 50 Hz and 25 degrees C and with a variation of less than 25% over the -25 to +100 degrees C range. The novelty is that the core is heat treated at 150-400 degrees C in a transverse magnetic field of rectangular waveform.
Patent DE-69837915-T2 (DE)
Inventor: ENRIGHT FREDERICK M
IPC: C07K7/23
Filed: 1998-03-27
Granted: 2008-02-21
Abstract: Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to specifically inhibit cells that are driven by or are dependent upon a specific ligand interaction; for example, to induce sterility or long-term contraception, or to attack tumor cells, or to selectively lyse virally-infected cells, or to attack lymphocytes responsible for autoimmune diseases. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gonadotropin-releasing hormone (GnRH) (or a GnRH agonist) and a membrane-active lytic peptide produces long-term contraception or sterilization in animals in vivo. Administering in vivo a combination of a ligand and a membrane-active lytic peptide kills cells with a receptor for the ligand. The compounds are relatively small, and are not antigenic. Lysis of gonadotropes has been observed to be very rapid (on the order of ten minutes). Lysis of tumor cells is rapid. The two components -the ligand and the lytic peptide- may optionally be administered as a fusion peptide, or they may be administered separately, with the ligand administered slightly before the lytic peptide, to activate cells with receptors for the ligand, and thereby make those cells susceptible to lysis by the lytic peptide. The compounds may be used in gene therapy to treat malignant or non-malignant tumors, and other diseases caused by clones or populations of "normal" host cells bearing specific receptors (such as lymphocytes), because genes encoding a lytic peptide or encoding a lytic peptide/peptide hormone fusion may readily be inserted into hematopoietic stem cells or myeloid precursor cells.
Patent DE-69838278-T2 (DE)
Inventor: SCHOFIELD PETER ROBERT
IPC: C12Q1/6883
Filed: 1998-06-10
Granted: 2008-05-15
Abstract: A method of assessing an individual's predisposition to bipolar affective disorder comprises determining the presence of one or more bipolar affective disorder-linked markers on chromosome 4 or analyzing allelic variation in relation to a bipolar affective disorder susceptibility gene on chromosome 4.
Patent DE-69908173-T2 (DE)
Inventor: HADDACH MUSTAPHA
IPC: A61P25/00
Filed: 1999-11-12
Granted: 2004-08-19
Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following structures: wherein n, m, R, R1, R2, X and Ar are as defined herein, including stereoisomes and pharmaceutically acceptable salts thereof.
Patent DE-69911680-T2 (DE)
Inventor: SPACCAROTELLA ANTONIO
IPC: B22D11/111
Filed: 1999-04-22
Granted: 2004-07-29
Abstract: In the continuous casting of steel, at the same time and in a plurality of zones of the mould different mould powders are utilised, if necessary continuously adapted to the specific instantaneous casting conditions present in said plurality of mould zones; products thus obtained are substantially free from surface defects.
Patent DE-69912369-T2 (DE)
Inventor: FELDERMANN CHRISTIAN JUAN
IPC: F23C6/02
Filed: 1999-08-20
Granted: 2004-07-15
Abstract: A method of combustion and an apparatus therefor in which separate streams of very lean and very rich fuel/oxidant mixture are combusted separately, the products of combustion therefrom being thoroughly mixed before final combustion takes place. The lean/rich primary combustion minimises combustion temperatures and pollutant formation, whilst the final combustion is substantially stoichiometric. <IMAGE>
Patent DE-69919415-T2 (DE)
Inventor: KAMATA KENICHI
IPC: G02B1/10
Filed: 1999-08-26
Granted: 2005-08-04
Abstract: A computer which receives data of color, density and gradient pattern as input, is connected to a printer which prints the print area (2) on print base (3) with ink, based on stored data. The formulation of print area is controlled by computer, to obtain a circular form of diameter larger than the lens (14).
Patent DE-69922657-T2 (DE)
Inventor: PERRING DOUGLAS
IPC: A61K8/40
Filed: 1999-07-06
Granted: 2005-05-25
Abstract: A perfume composition contains at least 15% by weight one or more defined aldehydes, and at least 30% by weight of at least one of five defined categories of hydroxylic materials, ketones, ethers, esters and nitriles. The perfume composition exhibits a deodorant effect, is particularly good at reducing sulphurous malodors, and is suitable for use in deodorant products, personal products and laundry treatment products.
Patent DE-69923335-T2 (DE)
Inventor: BHATNAGAR RAJIV
IPC: D06F33/02
Filed: 1999-07-05
Granted: 2006-01-12
Abstract: A digital electronic control unit that provides an efficient, miniature, reliable and cost-effective control mechanism for use in household and commercial appliances. It further is capable of real-time-based control, remote control and networking.
Patent DE-69924075-T2 (DE)
Inventor: CASTIN MICHEL
IPC: B60T7/10
Filed: 1999-11-25
Granted: 2006-02-02
Abstract: The automatic play adjuster for a motor vehicle parking brake has a lever acting on a pivoting yoke (4) on which one end of a tie rod (2) is articulated. In its external surface the tie rod comprises a stack of truncated projections forming successive stop notches (14). A compensator (7) fastened to the traction cable is able to act on the brake drum or disc and a compression spring (13) supported on an adjustable stop (11,12) is immobilized on the tie rod end (10) opposite the yoke. The compensator is applied against a nut (16) having a stack of internal truncated parts (15). The nut is split in two parts which are assembled together by an annular beading (19) enabling a resilient displacement of the these two parts so as to allow passage of the nut truncated parts onto one or more consecutive stop notches of the tie rod, as a result of a constant pressure force exerted on the nut by the compression spring.
Patent DE-69924751-T2 (DE)
Inventor: NISHITANI LTD
IPC: C07D501/56
Filed: 1999-11-25
Granted: 2006-03-09
Abstract: A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. <CHEM> wherein, X is N or CY and Y is H or halogen; R<1> is amino or protected amino; R<2> is hydrogen or optionally substituted lower alkyl etc.; R<3> is hydrogen etc.; R<4> is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R<5> is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.
Patent DE-69935169-T2 (DE)
Inventor: BUTLER MICHAEL
IPC: B23P19/00
Filed: 1999-08-03
Granted: 2007-10-31
Abstract: Fastener delivery apparatus for automatically selecting and delivering fasteners such as rivets to a setting tool (1). The fasteners are pre-loaded in a package (4) and dispense via at least one fastener delivery tube (6) that interconnects the setting tool (1) to a fastener feeder device (5). The fastener feeder device (5) releases selected fasteners from the package (4) into the delivery tube (6). The fasteners are transportable individually or in groups in the tube (6) from the feeder device (5) to the tool (1). A transfer station (7) attached to the tool (1) or the delivery tube (6) transfers a fastener from the delivery apparatus into the tool (1), the transfer station (7) being moveable between a first position in which an exit of the transfer station is adjacent to the tool (1) so that a delivered fastener may be inserted by the transfer station (7) into the tool (1) and a second position in which it is clear of the tool (1) so as to permit the tool (1) or a portion thereof to move towards a workpiece to insert a loaded fastener. The delivery tube (6) has wear resistant elements. The apparatus allows smooth, rapid and reliable delivery of fasteners of various sizes and types to the nose of a setting tool (1) in any particular order and provides all the fastener types for any particular work cycle.
Patent DE-69935599-T2 (DE)
Inventor: BERZOFSKY JAY A
IPC: C12N15/40
Filed: 1999-08-17
Granted: 2007-11-29
Abstract: Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L->A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO:1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
Patent DE-69936879-T2 (DE)
Inventor: CARLSSON OVE
IPC: H04M3/42
Filed: 1999-12-14
Granted: 2008-04-30
Abstract: Techniques for ascertaining the geographic position of users and terminals in a wireless communications system are used, for example, by operations personnel in performing system maintenance and by emergency personnel in locating lost or injured individuals. According to an exemplary method of requesting and obtaining user position information, user terminals in a wireless communications system routinely transmit position information to mobile switching centers in the system, and the mobile switching centers maintain up-to-date terminal position information in visiting location registers. Requests for user position information are routed to a home location register which in turn routes terminal position requests to mobile switching centers with which the target users are registered. Terminal position information is retrieved from the appropriate visiting location registers and sent back to the requesting parties with a minimum of system traffic.
Patent DE-69937332-T2 (DE)
Inventor: ZGARBA TONY
IPC: G06F9/06
Filed: 1999-11-10
Granted: 2008-07-24
Abstract: A method of round-trip engineering source code from a software model, and in particular a method of forward engineering code previously reverse engineered into a software model whereby to generate updated source code without any changes to the code not changed in the model, and without using obtrusive code markers in the source code. Elements from the original source code represented by the model are placed in a meta-model, and compared to a similar meta-model of the software model. Appropriate changes and additions are made in the source code to elements which have been changed in the software model. The rest of the code in the software model remains untouched.
Patent HU-E028956-T2 (HU)
Title: Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect
Inventor: THOMAS AMANDA
IPC: A61K31/15
Filed: 2009-10-30
Abstract: Provided herein are compositions comprising a dextromethorphan analog according to Formula I or Formula II or a pharmaceutically acceptable salt thereof of either of the foregoing, and a co-agent,  e.g. , an antidepressant such as a serotonin norepinephrine reuptake inhibitor; a serotonin noradrenaline dopamine reuptake inhibitor; a norepinephrine dopamine reuptake inhibitor; a monoamine oxidase inhibitor; a selective serotonin reuptake inhibitor; and a tricyclic antidepressant or a pharmaceutically acceptable salt of any of the foregoing. The compositions are useful in the treatment of pseudobulbar affect, neuropathic pain, neurodegenerative diseases, brain injuries, and the like.
Patent TR-200001969-T2 (TR)
Title: 17-Değiştirilmemiş 16.beta.-ariloksi 4-azasteroidlerin sentezleri için arabileşikler ve işlem.
Inventor: HUMPHREY GUY R
IPC: C07D473/00
Filed: 1998-12-18
Abstract: Bu bulusun yeni islemi bazi 16-degistirilmis 4-aza-5alfa-androst-1-en-3-onlarin stereo-seçici sentezini ve burada elde edilen yararli ara bilesiklerini içerir.
Patent TR-200200625-T2 (TR)
Inventor: WOERNER CARSTEN
IPC: C08L59/00
Filed: 2000-09-01
Abstract: Polyoxymethylene with improved resistance to acids, comprising A from 84 to 99.79% by weight of at least one polyoxymethylene homo- or copolymer, B from 0.1 to 5% by weight of at least one polyalkylene glycol, C from 0.1 to 10% by weight of zinc oxide, and D from 0.01 to 1% by weight of one or more nitrogen-containing costabilizers, where the total of the percentages by weight of components A to D is 100%. This polyoxymethylene is particularly advantageous when used for producing moldings for use in contact with aggressive acids or with aggressive acid-containing cleaning agents, in particular for applications in the sanitary sector or the white goods sector.
Patent TR-200402566-T2 (TR)
Title: Bitki transformasyon yöntemleri.
Inventor: HANSEN GENEVIEVE
IPC: A01H1/00
Filed: 1998-05-29
Abstract: Bitkilerin, özellikle Gramineae'nin Agrobacterium transformasyonu için, Agrobacterium'un neden oldugu nekrozu inhibe edebilen kosullari kullanan iyilestirilmis bir yöntemdir.
Patent DE-602004000493-T2 (DE)
Inventor: OEPPING JAMES M
IPC: A01G7/06
Filed: 2004-07-27
Granted: 2006-08-31
Abstract: An apparatus, method and system for applying a biologically active or chemical substance to a relatively large volume harvested or pre-harvested crop includes relatively small container (20) of a mixture biologically active or chemical substance and water in fluid communication with fluid conduit (14). A pump (40) moves mixture from the bottle through the conduit. A source (40) of pressurized air is in fluid communication with the conduit to aerate the mixture. The aerated mixture is expelled through a nozzle (12) at distal end of the conduit. In one aspect, the controller (80) can monitor speed of the pump by monitoring operating voltage of the pump. Speed of the pump can be adjusted to adjust application rate. In one aspect, a process combines a flow of air through an orifice with the metering of a low volume of additive, such as an aid to preservation, to a crop as it is being cut or harvested to provide for even distribution of the additive to the crop.
Patent DE-602004001125-T2 (DE)
Inventor: BERLEMONT JEAN-FRANCOIS
IPC: H01L41/08
Filed: 2004-03-11
Granted: 2007-01-04
Abstract: A method of assembling a fuel injector (8) comprising a fuel injector body having an accumulator volume (22) defined therein is described. The method comprises: providing an encapsulated actuator arrangement (29a) having a piezoelectric actuator stack (29) and electrical connector means (34,36), wherein the stack (29) is encapsulated in a sleeve member (30); providing a volume of sealing material (42) in the region of the electrical connector means (34,36); locating the encapsulated actuator arrangement (29a) in the accumulator volume (22); applying heat indirectly to the volume of sealing material (42) so as to soften the volume of sealing material; and applying pressure to the encapsulated actuator arrangement (29a) such that the volume of sealing material (42) deforms to form a substantially fluid-tight seal (38) between the encapsulated actuator arrangement (29a) and the accumulator volume (22) in the region of the electrical connector means (34,36). <IMAGE>
Patent DE-602004012851-T2 (DE)
Inventor: FRANZ BURKHARD
IPC: A61M39/22
Filed: 2004-05-19
Granted: 2009-04-09
Abstract: A hand-held device (10) for creating a pressure change in a person's ear canal. It has an interior space forming an air chamber (50), a plunger (58) and a valve means (52) frictionally engaged with said plunger (58), a tube (14) with an earpiece (48), and a finger-actuated diaphragm (60) in an external wall of the air chamber (50). The diaphragm (60) moves the plunger (58) from a resting position, and in a first direction. A spring (56) returns the diaphragm (60) to its undepressed position. Initial movement of the plunger (58) in said first direction from said resting position displaces the valve (52) from a first position to a second position at which the valve means (52) is stopped from further movement in said first direction. Further movement of the plunger (58) in said first direction causes the plunger (58) to slide relative to the valve (52). The device (10) is intended for treatment of Mënière's disease and ear pain from other causes. A1
Patent DE-602005001004-T2 (DE)
Inventor: VAN HILLO ERIC ADRIAAN
IPC: A22C21/00
Filed: 2005-02-08
Granted: 2008-01-10
Abstract: The invention relates to an apparatus for severing a drumstick (1) and a thigh (2) that are part of a leg of poultry from each other, comprising an overhead conveyor for supplying the suspended leg, a supporting member (5) for supporting the leg while the drumstick and thigh are being severed, and a cutting device (6) for severing the drumstick from the thigh at the height of a knee joint, wherein a clamping device (7,8) is provided for holding fast the thigh (2) at least while it passes the cutting device (6).
Patent DE-69025612-T3 (DE)
Inventor: ROBINSON STEPHEN E
IPC: A61B10/00
Filed: 1990-12-13
Granted: 2003-08-14
Abstract: Signals produced by brain activity are measured by each sensor of an array of magnetic and/or electrical sensors external to but proximate to the head (or other portion of the body) of a subject. The measurements obtained simultaneously from all of the sensors are combined in a manner to permit selective measurement of the electrical activity from a specified location within the body, or alternatively, to permit the location in the body producing a particular type of response to be identified. The instantaneous measurement of each sensor is scaled by a weighting coefficient for that sensor, and the products added over all of the sensors. Preferably, the weighting coefficients are calculated from the covariance matrix of the measurements made by the array of sensors. Alternatively, the weighting coefficients may be calculated from a mathematical model of the portion of the body being measured that includes information on the shape of the potential source, the extent or type of source activity, the electrical and magnetic properties of the media, and the locations and orientations of the sources and the sensors.
Patent DK-1106312-T3 (DK)
Inventor: REIFENHAEUSER UWE DIPL-ING
IPC: B26D1/16
Filed: 2000-11-04
Granted: 2006-06-06
Abstract: The cube-cutting and slicing machine has an insertion shaft (2) for the foodstuffs. The cutting device has a grating cutter and a rotary slicing cutter (7S). The internal cross section of the insertion shaft can be altered by altering the position of at least one of its long walls (10S). The output cross section of the insertion shaft can be enlarged via the effective cutting cross section in grating cutting mode.