baber/WOPTO huggingface dataset:
Patent DE-69012934-T2 (DE)
Inventor: BAKER RODNEY CYRIL
IPC: A61K9/24
Filed: 1990-07-06
Granted: 1995-03-02
Abstract: A solid pharmaceutical composition for release of a biologically active substance into a desired aqueous environment, containing a core and an outer layer, said core comprising between 17 and 93% by weight of the biologically active substance, between 0.01 and 7% by weight of a water swellable polymer material and between 0 and 83% of one or more accessory ingredients, relative to the total weight of the core; and the outer layer comprising between 25 and 75% by weight of the biologically active substance, between 25 and 75% by weight of a material for enabling rapid dispersion of the outer layer into the aqueous environment and 0 to 50% by weight of one or more accessory ingredients, relative to the total weight of the outer layer. The composition is preferably formulated as a bolus for veterinary use.
Patent DE-69016655-T2 (DE)
Inventor: BURNIER JOHN
IPC: C07K16/22
Filed: 1990-04-04
Granted: 1995-08-17
Abstract: A polypeptide is provided that excludes (a) a full-length mature TGF- beta  molecule or precursor TGF- beta  molecule or deletion variants of mature or precursor TGF- beta  molecules in which from about 1 to 10 amino acid residues have been deleted, (b) a polypeptide of the sequence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp-Leu-Gly-Trp-Lys, and (c) a polypeptide of the sequence: Arg Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg-Gln-As p-Leu, said polypeptide comprising an amino acid sequence that is based on conserved sequences in the family of TGF- beta  molecules. Such polypeptides are particularly useful therapeutically as immunosuppressive agents when coupled to carrier proteins or crosslinked to form polymers.
Patent DE-69024998-T2 (DE)
Inventor: SAYERS IAN CHRISTISON
IPC: D06H5/00
Filed: 1990-04-30
Granted: 1996-09-05
Abstract: A method of joining the ends of papermakers fabric is disclosed wherein machine direction yarns (12) are fringed out at the fabric ends, yarn ends (16) being laid across a pinned plate (13), and yarn ends (20) being cut back so as partially to overlie the plate. Those yarns (16) which extend across the plate (13) are folded back to form loops (14) beyond the edge of the plate and a thermoplastics matrix material (17) is applied to the plate. The matrix material (17) is made fluid by heating and, on subsequent cooling, forms an apertured end to the fabric which presents side-by-side, outwardly extending loops (14). The loops (14) at the respective fabric ends may be interdigitated to receive a pintle wire, thus to bring the fabric into endless form. A variation of the method is disclosed wherein a reticulate, premoulded seam element is engaged with the pinned plate for attachment to machine direction yarns of the fabric on melting of the matrix material, the seam element including axially aligned tunnels at a free edge thereof for cooperation with similar formations at an opposed fabric end and to receive a pintle wire.
Patent DE-69025150-T2 (DE)
Inventor: SIXSMITH DAVID GEORGE
IPC: A61K9/00
Filed: 1990-12-05
Granted: 1996-05-30
Abstract: A gelatin-treated polyhydric alcohol is suitable as a carrier for medicinal agents, especially in lozenge form, for delayed dissolution on oral administration.
Patent DE-69032579-T2 (DE)
Inventor: MARRA MARIAN
IPC: A61P31/04
Filed: 1990-02-14
Granted: 1999-02-11
Abstract: The present invention provides a method of inhibiting lipopolysaccharide (LPS)-mediated stimulation of cells. This method comprises contacting the cells, in the presence of a cell-stimulating amount of lipopolysaccharide, with bactericidal/permeability increasing protein (BPI) in an amount effective to inhibit cell stimulation.
Patent DE-69033681-T2 (DE)
Inventor: EDELMAN M
IPC: G06V10/764
Filed: 1990-10-10
Granted: 2001-08-02
Abstract: An apparatus capable of sensing the presence of objects in its environment, categorizing these objects without a prior description of the categories to be expected, and controlling robotic effector mechanisms to respond differentially to such objects according to their categories. Such responses include sorting objects, rejecting objects of certain types, and detecting novel or deviant objects. The invention includes a device called a "classification n-tuple" (of which a "classification couple" is a special case) capable of combining signals from two or more sensory modalities to arrive at the classification of the object. The invention operates by simulating certain features of animal nervous system, including neurons with responses determined at each moment of time by inputs received along synaptic connections from sensory means or form other neurons. In this invention, neurons are arranged in "groups", which permits them to act cooperatively while still retaining characteristic individual responses. Groups in turn are arranged in "repertoires", which provide a totality of response specificities sufficient to respond to any of a range of possible input objects. Some of these repertoires are organized as "maps", such that groups responding to inputs that are similar along some dimensional (spatial or abstract) are close together in the repertoire, enabling the repertoire to respond correctly to novel objects that are similar to objects it has encountered previously. Maps in this invention are linked by connections, called "reentrant" connections, that enable the responses of one map to be reentered into the system as inputs to another map. Reentrant connections permit signals from different sensory modalities to be correlated in an ongoing fashion, and they are the basis for the operation of classification n-tuples. The responses of the apparatus of this invention may be improved and optimized for a particular task through the operation of "neuronal group selection", a process which enhances the responses of those neuronal groups in the apparatus which were active in some time interval preceding the production of a useful output action. This process operates by modifying the strength of selected synaptic connections. The value of various output actions is determined, for the purpose of regulating selection, by means which are internal to the apparatus of this invention. Accordingly, the invention is capable of self-organization and learning, and does not require a predetermined specification of correct responses for all possible inputs.
Patent DE-69104615-T2 (DE)
Inventor: KANEKO NOBORU
IPC: C07D217/04
Filed: 1991-07-10
Granted: 1995-03-23
Abstract: A novel diphenylmethylpiperazine derivative represented by general formula (I) wherein R represents (a) or (b). It has an action of inhibiting the overcontraction and overextension of cardiac muscles without being accompanied with a cardioinhibitory action, so that it can be used as the active ingredient of an inhibitor for the necrosis of cardiac muscles and a drug for treating and preventing acute myocardial infarction. <CHEM>
Patent DE-69104988-T2 (DE)
Inventor: ALLARD ROLAND
IPC: A61K8/97
Filed: 1991-08-02
Granted: 1995-05-18
Abstract: PCT No. PCT/FR91/00640 Sec. 371 Date Feb. 9, 1993 Sec. 102(e) Date Feb. 9, 1993 PCT Filed Aug. 2, 1991 PCT Pub. No. WO92/02254 PCT Pub. Date Feb. 20, 1992.The invention relates to microcapsules having a combined atelocollagen/polyholoside coagulated wall as well as to a method for producing them. According to the invention, the microcapsules are characterized in that they include a combined atelocollagen/polyholoside wall coagulated by a coagulant, preferably a divalent cation. These microcapsules are preferably prepared by a method which includes laminar-flow extrusion dislocated by individual droplet vibrations falling into a coagulation bath. The presence of the atelocollagen renders the microcapsules biocompatible. They are particularly suitable for the production of cosmetic, pharmaceutical or food compositions.
Patent DE-69108031-T2 (DE)
Inventor: MACKENZIE ROBIN
IPC: E04F15/20
Filed: 1991-05-23
Granted: 1995-11-09
Abstract: PCT No. PCT/GB91/00810 Sec. 371 Date Jan. 29, 1993 Sec. 102(e) Date Jan. 29, 1993 PCT Filed May 23, 1991 PCT Pub. No. WO91/19064 PCT Pub. Date Dec. 12, 1991.A floor construction on a support means of timber joists (10) consists of floor boards (11, 12) laid on battens (13) each having a lower horizontal surface faced with a material (14) for attenuating transmission of sound. The battens (13) consist of plywood strips about 5 mm thick and the same width as the joists. (10). The battens (13) are less stiff than the floor boards (11, 12). Thus, energy delivered to the sound attenuating material (14) is increased. The material (14) included open-cell and closed-cell layers (14B, 14A); and the upper layer (14A) has lateral flaps (15) folded down and nailed to the sides of the joists (10). The floor construction has improved sound attenuating qualities; the reduced batten thickness allows easier installation in certain circumstances; and the lateral flaps also assist installation.
Patent DE-69109066-T2 (DE)
Inventor: SALA ALBERTO
IPC: A61K31/5415
Filed: 1991-11-29
Granted: 1995-09-21
Abstract: Benzoxazinone and benzothiazinone derivatives of formula <CHEM> wherein R represents hydrogen, (C2-6)alkyl, (C5-7)cycloalkyl, phenyl, substituted phenyl; R1 and R2 independently represent hydrogen, halogen, (C1-4)alkyl, (C1-4)alkoxy or trifluoromethyl; X is oxigen or sulfur; Y is (C2-6)alkylene or (C5-7)cycloalkylene; and salts therewith of pharmaceutically acceptable acids. The compounds possess cardiovascular activity with high specificity for the coronary district.
Patent DE-69119907-T2 (DE)
Inventor: BORNEMAN WIM
IPC: A61M36/12
Filed: 1991-07-12
Granted: 1996-10-02
Abstract: The invention relates to a device for introducing a source of radioactive radiation into the body for therapeutic applications, comprising a flexible cable (10) to be introduced into the body through a catheter and a capsule (12), for sealingly containing the source (14) of radioactive radiation. The capsule (12) comprises a thin-walled (17) tubular reservoir having an open end which is sealingly connected to the flexible cable (10) so that the capsule is coaxial to the flexible cable and having closed end (15) with a rounded-off external shape. The capsule accommodates a quantity of iridium-192 (14) of a capacity sufficient for therapeutic application. The radioactive source (14) of iridium-192 is provided within the capsule (12) in the form of a single bar.
Patent DE-69119974-T2 (DE)
Inventor: DAVIS JAMES O
IPC: H01B7/08
Filed: 1991-03-27
Granted: 1997-04-17
Abstract: A multiconductor and support has a plurality of elongate conductive elements (19) each with a pair of termini. An elongate support means (20), carrying adjacent conductive elements, has openings (32) located at the distal and the proximal ends for alignment with conductive elements extending thereover leaving the distal termini thereof unsupported. Heat activated adhesive on the support means bonds the conductive elements. Each of the conductive elements are spaced from the other conductive elements and have center lines which are parallel. A machine for assembly of a multiconductor and support means has a plurality of spools supplying conductive elements and a plurality of guides each positioned to receive and align the supplied conductive elements. The guides position the conductive elements spaced from and parallel to each other. A supply of support means moves support means intermittently but synchronously between the conductive elements and a flat surface. A heated platten compresses and bonds the conductive elements and the support means into an pair. A method for assembling a multiconductor and support includes intermittently moving several conductive elements in parallel spaced relation and intermittently moving a support means in a plane parallel to the conductive elements. Pressing the parallel conductive elements and the support means together forms the pair. <IMAGE>
Patent DE-69123205-T2 (DE)
Inventor: DUNPHY PATRICK JOSEPH
IPC: C09K23/38
Filed: 1991-07-11
Granted: 1997-04-30
Abstract: A cosmetic emulsion suitable for topical application to the lips comprises in addition to oil and water, an emulsifier system comprising:     i) as a first emulsifier, a phospholipid, and ii) a second emulsifier having a melting point of from -20 DEG C to 80 DEG C.   Preferred emulsions are lipsticks and lip gloss product which can additionally comprise wax.
Patent DE-69125262-T2 (DE)
Inventor: DEZIEL ROBERT
IPC: A61K31/522
Filed: 1991-12-21
Granted: 1997-10-09
Abstract: Disclosed herein is a combination of an antiviral nucleoside analog and a ribonucleotide reductase inhibiting peptide derivative. The combination is useful for treating herpes infections.
Patent DE-69125383-T2 (DE)
Inventor: REITER HARVEY
IPC: A23L3/3463
Filed: 1991-08-29
Granted: 1997-07-31
Abstract: An acid-stabilized foodstuff is prepared with at least one polymeric food-acceptable acid.
Patent DE-69125607-T2 (DE)
Inventor: DELALLE JACQUES
IPC: H01R4/02
Filed: 1991-06-24
Granted: 1997-11-20
Abstract: A device (1) for forming an electrical connection at the end of a bundle of wires (2) comprises an electrically insulating, preferably heat-shrinkable, sleeve (3), a metallic connecting element (4) located within the sleeve, and a quantity of solder (8) for forming a permanent electrical connection between the conductors. The connecting element (4) has a tapering internal surface which has a screw thread so that a temporary electrical connection can be formed by screwing the bundle of wires into the connecting element. Preferably the connecting element is formed by winding a wire, e.g. hard tempered copper wire, into a frusto-conical form. Splices in wire bundles may be made by means of a device in which the connecting element has a pair of internally threaded portions into which different cable bundles can be screwed.
Patent DE-69133299-T2 (DE)
Inventor: PICARD ARMAND
IPC: A61K31/403
Filed: 1991-11-05
Granted: 2004-01-22
Abstract: A compound of the following general formula which is useful in treating hypercholesterolemia and atherosclerosis:   <IMAGE>   wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a heterocyclic group, or a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds and each of R2 and R3 is selected from hydrogen, provided both are not hydrogen, an aralkyl group, a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds, an w-substituted alkylC1-6, a heterocyclic group, phenyl, substituted phenyl or NR2R3 taken together form a monocyclic heterocyclic group.
Patent DE-69200913-T2 (DE)
Inventor: LINDGREN ERIK
IPC: B65D65/42
Filed: 1992-10-06
Granted: 1995-04-13
Abstract: The present invention relates to a packaging material for reduced transfer from a package to its content of substances causing undesirable taste and/or hazardous substances, this reduction being due to the packaging material containing a hydrophobic zeolite. More specifically, the invention concerns paperboard, in which case the substances causing undesirable taste mainly are naturally occurring extractive substances, oxidation products thereof and, to a lesser extent, the paper chemicals present. Further, the presence of a hydrophobic zeolite in the paperboard enhances the water-repellent (hydrophobic) capacity. Also, the present invention concerns a method for production of a packaging material of paper, board or paperboard by forming and dewatering a suspension of lignocellulose-containing fibres, where the dewatering takes place in the presence of a hydrophobic zeolite. Moreover, the present invention relates to the use of a hydrophobic zeolite for production of a packaging material, as well as the use of the thus-produced packaging material in packages for solid or liquid foodstuff, tobacco or medicines.
Patent DE-69203995-T2 (DE)
Inventor: BLAZEK OLDRICH
IPC: H01H47/04
Filed: 1992-08-24
Granted: 1996-03-21
Abstract: The circuit comprises an oscillator (IC1) producing, by means of the coil (B) of the electromagnet, voltage pulses charging a capacitor (C1) at a voltage greater than the supply voltage for the circuit. This capacitor discharges across a thyristor (TH) and the coil (B) when its voltage reaches the blocking voltage of a Zener diode (ZD1) controlling the trigger of the thyristor. The current pulses in the coil of the electromagnet are insufficient to actuate the electromagnet, but sufficient to keep its armature attracted. <IMAGE>
Patent DE-69204302-T2 (DE)
Inventor: EDWARDS ROBERT
IPC: F01M11/04
Filed: 1992-11-30
Granted: 1996-01-25
Abstract: A fluid exchange apparatus for the transfer of fluids from a first containment area to a second containment area, including a total fluid reconciliation process, whereby the same amount of fluid transferred from the first containment area to the second containment area is replenished into the first containment area, or is replenished to a preset amount. The fluid exchanger includes an evacuation section having a vacuum pump therein, and a fill section. The fluid being vacated from the first containment area is transferred to the second containment area by vacuum pressure introduced into the first containment area. An air purge is used to drive fluid out of the fluid passages/filters into the first containment area. The pressure may be developed internally to the fluid exchange apparatus or externally thereto. CPU controlled electronics are utilized to measure, monitor, and control, via a user interface screen, the fluid exchange machine.
Patent DE-69208615-T2 (DE)
Inventor: BORNHORST JAMES M
IPC: F21V9/40
Filed: 1992-07-22
Granted: 1996-10-24
Abstract: A lighting instrument projects a light beam of variable color along a longitudinal axis (12). Sets of color filters (20) are disposed generally radially about the longitudinal axis of the light beam. The filters of each set are pivotable about an axis of rotation (18) generally transverse to the longitudinal axis. Each filter is flexibly coupled to a ring (24) which in turn is coupled to a motor (26). When the motor actuates, the ring rotates about the longitudinal axis, causing each coupled filter of the set to rotate. <IMAGE>
Patent DE-69221606-T2 (DE)
Inventor: PIZZI GIORDANO
IPC: H01R13/60
Filed: 1992-05-27
Granted: 1997-12-18
Abstract: The present invention relates to an integrated terminal block construction fixedly coupled to a plug, which comprises a terminal block body connected with a cable which is associated with a plug, the terminal block body including, on a surface thereof, electrical contacts which are wired or connected with the electrical conductors of the cable, the terminal block body being moreover provided with means for connecting the body to a supporting sheet metal plate to which the ground contact of the terminal block can be connected. <IMAGE>
Patent DE-69225758-T2 (DE)
Inventor: SAKAKI MAMORU
IPC: B41J29/17
Filed: 1992-09-10
Granted: 1998-12-24
Abstract: An input stack of recording sheets and cleaning paper is provided. Each sheet is formed of a coated layer including pigment on a base material, while each cleaning paper has an adhesion strength ranging from 1 to 500 gf defined by JIS-Z-0237 and determined by a 90 DEG peel method and is interspersed in the recording sheets. <IMAGE>
Patent DE-69227842-T2 (DE)
Inventor: CREMONA LORENZO
IPC: B26D1/40
Filed: 1992-02-10
Granted: 1999-04-29
Abstract: A device (15, 15') for transverse cutting of a wood veneer strip by means of a blade rotating around an axle for getting in contact transversely with the strip has a blade consisting of two sections (21, 22; 57, 58) independently controllable along the axle. Means (19, 30, 66) for synchronizing the blades are provided for performing jointly, on command, a continuous cut along the entire width of the strip. <IMAGE>
Patent DE-69305759-T2 (DE)
Inventor: WIELLIGH JOHANNES LOUW K VON
IPC: A24F47/00
Filed: 1993-02-19
Granted: 1997-06-12
Abstract: A product for assisting a smoker in giving-up the smoking habit consists of at least three and preferably four pump operated aerosol cans. Each can, apart from one, contains nicotine in liquid form dispersed in at least one pharmaceutically acceptable carrier. The cans which contain nicotine have differing quantities of nicotine in them. Pharmaceutically acceptable carriers are alcohol, a flavouring, glycerine and saccharine. The volume of alcohol and glycerine increases as the percentage of nicotine decreases. The can which does not contain nicotine merely comprises one or more pharmaceutically acceptable substances.
Patent DE-69308309-T2 (DE)
Inventor: KELLY PAUL
IPC: C08F283/01
Filed: 1993-08-02
Granted: 1997-08-14
Abstract: The invention is a curable resin composition comprising A) an epoxy vinylester resin or a polyester resin; B) a polymerizable monomer; C) a chelating agent; and D) a copper salt or complex of copper with an alcohol, aldehyde or ketone; and E) an inhibitor comprising alkylated phenolic compound or polyhydroxy aromatic compound. In another aspect it is a resin system comprising I) a resin composition comprising: A) an epoxy vinylester resin or a polyester resin; B) a polymerizable monomer; C) a chelating agent comprising a polar or aromatic ring containing compound; D) a copper salt or a copper complex with an alcohol, ketone or aldehyde; and E) an inhibitor comprising alkylated phenolic compound or a polyhydroxy aromatic hydrocarbon and I) a catalyst system which comprises E) an additional amount of an inhibitor; F) optionally an aliphatic amine, an aromatic amine, or a heterocyclic amine; G) a peroxide or persulphate initiator; and H) a transition metal accelerator. In another embodiment the invention is a method of curing a curable resin composition which comprises contacting the resin composition (I) with a catalytic amount of the catalyst composition (II) optionally contacting the mixture with a reinforcing structure and allowing the composition to cure; under conditions such that the peak exotherm 100 grams of the reaction mass is from 40  C to 120  C and the cure time is from 30 to 120 minutes.
Patent DE-69308833-T2 (DE)
Inventor: SOREQ HERMONA
IPC: A61P35/00
Filed: 1993-04-15
Granted: 1997-06-19
Abstract: PCT No. PCT/EP93/00911 Sec. 371 Date Dec. 1, 1994 Sec. 102(e) Date Dec. 1, 1994 PCT Filed Apr. 15, 1993 PCT Pub. No. WO93/21202 PCT Pub. Date Oct. 26, 1993The invention relates to synthetic phosphorothioated or partially phosphorothioated oligodeoxynucleotides capable of selectively modulating hemopoietic bone marrow cells development. More particularly, the invention relates to synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE or 2HS genes, having phosphorothioate bonds linking between the nucleotide bases; synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE gene, 2HS gene or BCHE gene or against a 5'-region in the human CHED (cdc2 homolog) gene, having phosphorothioate bonds linking between the four 3'-terminus nucleotide bases. The invention also relates to pharmaceutical compositions comprising as active ingredient at least one synthetic phosphorothioated or partially phosphorothioated antisense oligodeoxynucleotides according to the invention in physiologically acceptable carrier in diluent. The antisense oligodeoxynucleotides of the invention and the pharmaceutical compositions containing them are suitable for inhibiting abnormal hemopoietic cells proliferation, inhibiting abnormal platelet proliferation, increasing stem cell fraction in bone marrow cell cultures, enhancing macrophage production and increasing stem cells counts, reducing immune response of organs to be transplanted, suppressing immune response of a recipient of an allotransplanted organ, and arresting growth of malignant tumors.