Patent SG-11201909977P-A (SG)
Title: Characteristic metabolites in miscarriages
Inventor: Tan Thiam Chye
IPC: G01N33/74
Filed: 2018-04-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT mu °million °nolo mooloin moilmioluo oimIE (10) International Publication Number WO 2018/199849 Al (51) International Patent Classification: GO1N 33/74 (2006.01) GO1N 33/493 (2006.01) (21) International Application Number: PCT/SG2018/050208 (22) International Filing Date: 30 April 2018 (30.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201703502T 28 April 2017 (28.04.2017) SG (71) Applicants: SINGAPORE HEALTH SERVICES PTE. LTD. [SG/SG]; 31 Third Hospital Avenue, #03-03, Bowyer Block C, Singapore 168753 (SG). NANYANG TECH- NOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Av- enue, Singapore 639798 (SG). (72) Inventors: TAN, Thiam Chye; c/o KK Women's and Children's Hospital Pte. Ltd., 100 Bukit Timah Road, Sin- gapore 229899 (SG). KU, Chee Wai; c/o KK Women's and Children's Hospital Pte. Ltd., 100 Bukit Timah Road, Singapore 229899 (SG). TAN, Nguan Soon; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). TAN, Zhen Wei; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: CHARACTERISTIC METABOLITES IN MISCARRIAGES (57) : Disclosed herein are methods of identifying the risk of a miscarriage in a subject comprising detecting and measuring the concentration of at least one metabolite in a sample obtained from the subject. Specifically, an increase in concentration of tetrahy- drocortisone, and a decrease in concentration of propionylcarnitine, isovalerylcarnitine, 3- methylglutarylcarnitine, hexanoylcarnitine or 3a,20a-dihydroxy-5[3-pregnane-3-glucuronide in a serum or a urine sample are associated with spontaneous miscarriage in first trimester pregnancy. Also disclosed herein are kits for determining the risk of a miscarriage in a subject.